SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
The sustainable development of first world war heritage between the Alps and the Adriatic

The peculiarity of the programme area is the presence of WW1 heritage, of extraordinary historical significance, sometimes poorly preserved, with untapped potential for tourism development. The project will contribute to transforming the current situation through shared cross-border activities aimed at the long-term conservation of WW1 heritage and increasing its use in view of the development of sustainable cultural tourism. Studies, exhibitions, cultural and commemorative events will be carried out to strengthen the general knowledge and awareness of WW1 heritage. Targeted training and networking activities for tour operators, organisations and other stakeholders will be carried out to encourage the development of the new tourism offer. To strengthen the joint promotion and marketing of WW1 heritage, a main Peace Trail brand with marketing guidelines, a website and other dissemination material will be introduced. New thematic routes, info-points and centres with interactive and innovative heritage presentations will be updated and organised. Small scale investments will be aimed at preserving WW1's extraordinarily valuable heritage.
Risk Corridors and Reinsurance in Health Insurance Marketplaces: Insurance for Insurers

Health Insurance Marketplaces established by the Affordable Care Act implement reinsurance and risk corridors. Reinsurance limits insurer costs associated with specific individuals, while risk corridors protect against aggregate losses. Both tighten the insurer's distribution of expected costs. This paper compares the economic costs and consequences of reinsurance and risk corridors. We simulate the insurer's cost distribution under reinsurance and risk corridors using data for a group of individuals likely to enroll in Marketplace plans from the Medical Expenditure Panel Survey. We compare reinsurance and risk corridors in terms of risk reduction and incentives for cost containment. We find that reinsurance and one-sided risk corridors achieve comparable levels of risk reduction for a given level of incentives. We also find that the policies being implemented in the Marketplaces (a mix of reinsurance and two-sided risk corridor policies) substantially limit insurer risk but perform similarly to a simpler stand-alone reinsurance policy.
AIR CONDITIONER ION GENERATOR

An ion generator (12) is configured to allow its attachment to the unmodified indoor-section of an air conditioning unit (10). The ion generator (12) has a) an ion gun located proximate to the path of an air stream exiting the condenser unit of the air conditioner, the ion gun has at least one sharp needle (24); b) two parts (30, 36) metallic duct casing (22) electrically isolated from the needle (24); c) a high power supply (48) connected to the needle (24) to cause a corona discharge and the generation of ions, the power supply (48) is disposed remotely from the sharp needle (24); and d) a low voltage power supply (62) connected to the first part (30) of the metallic duct (22).
Identification and functional validation of novel enhancer sequences involved in pituitary gland development and pathology

There is a fundamental gap in understanding how the GPR101 gene regulates human growth in physiological and pathological conditions. Children’s growth is remarkably clinical relevant and is an important indicator of their health and general well-being. The specific objective of this proposal is to identify the molecular mechanisms underlying GPR101 overexpression in the pituitary tumors of children with GPR101 duplications causing X-linked acrogigantism (X-LAG).
My central hypothesis is that GPR101 duplications disrupt the structure of the local chromatin, leading to the creation of a new chromatin domain where de novo enhancer-promoter interactions take place, causing abnormal GPR101 expression. This hypothesis will be tested by pursuing three specific aims:
1.	Elucidate the transcriptional regulation of GPR101 in normal and pathological conditions
2.	Identify and functionally characterize novel pituitary-specific enhancer sequences
3.	Investigate these regulatory sequences in patients with different pituitary pathologies.
To achieve aim 1) I will perform an in vitro functional characterization of GPR101 promoter: promoter activity will be studied by luciferase-based reporter assays, by conducting a methylation analysis, and by determining its accessibility to transcription factors.
To achieve aim 2) I will  validate my preliminary results showing the formation of a novel chromatin domain by 4C-Seq. Four putative enhancer sequences located within the duplicated GPR10 region and identified in silico will be functionally evaluated in vitro to establish their impact on transcriptional activity. To identify novel pituitary-specific enhancers, a whole-genome profile of enhancer-specific histone marks will be performed in normal and tumoral pituitary cells by ChIP-Seq.
To achieve aim 3) I will screen patients with different pituitary disorders for mutations (Sanger sequencing) and structural variations (CNV assays) in the functionally-verified enhancers.
DEVICE FOR AUTOMATICALLY FEEDING CURTAIN HOOKS TO A SEWING MACHINE

For feeding curtain hooks, each consisting of a strip (1) and the hook (5) connected thereto, to a sewing machine which can sew the strip of an infed curtain hook onto a curtain pleat, use is made of a device comprising a storage holder (12) for the curtain hooks, and movement means (9) for moving one curtain hook at a time from the storage holder (12) to a desired position for sewing on the strip of that curtain hook. According to the invention, the movement means (9) move the curtain hooks only in one straight line, the storage holder (12) is in the form of a vertical tube in which the curtain hooks can be stored stacked on top of one another, the bottom end of the storage holder (12) lies in or just above the straight movement path of the moving part (25) of the movement means (9), so that said moving part (25) can pick up the bottom hook in the storage holder (12), and the moving part (25) of the movement means (9) can return to the initial position during sewing on of the strip of the curtain hook held in position by the pressure foot of the sewing machine.
AN INFLATABLE HOSE SYSTEM

An inflatable hose system which may act as a boom for rescue purposes or for controlling the flow of surface borne contaminants of rivers, lakes and seas and comprising first and second hose lengths (10, 11) each having one end (12) flattened and sealed to be chiselshaped and the other end provided with a coupling (15, 16). The two lengths (10, 11) and any interposing standard hose lengths may thus be coupled together and inflated to a pressure in the range of 2 to 3.5 bar to provide a boom of the required length, and one of the hose lengths includes an inflation valve (20). The hose length may be connected together in mutual alignment thus to produce a straight boom or with the interposition of elbows to form a curved boom capable of containing floating objects or substances.
Hepatitis B Virus Infection among Japanese Immigrants and Descendants: The Need to Strengthen Preventive and Control Measures

This cross-sectional study aimed to investigate the prevalence and risk factors of Hepatitis B virus infection among Japanese immigrants and their descendants from São Paulo (SP), and to verify the occurrence of occult hepatitis B and coinfection with HCV, Delta, and HTLV. All samples (n = 2.127) were tested for HBV serological markers by electrochemiluminescence. HBsAg and/or total anti-HBc positive samples were tested for HBV DNA by real-time PCR, and genotyped by sequencing using the Sanger methodology. The prevalence rate of HBV exposure was 13.4% (CI 95%: 11.9-14.9%), and 22 (1.1%) were HBsAg positive. A high rate of susceptibility to HBV infection was found (67.4%; CI 95%: 65.4-69.4%). In contrast, only 19.2% (CI 95%: 17.6-20.9%) presented a serological profile analogous to that elicited by Hepatitis B vaccination. HBV isolates (n = 8) were classified as genotypes HBV/B1 (62.5%), HBV/C2 (12.5%), HBV/F1b (12.5%), and HBV/A1 (12.5%). Hepatitis B vaccination strategies and educational measures to control this infection should be considered.
Deciphering deep architectures underlying structured perception in auditory networks

The principles of sensory perception are still a large experimental and theoretical puzzle. A strong difficulty is that perception emerges from networks of recurrently connected brain areas whose activity and function are poorly approximated by current generic mathematical models. These models also fail to explain many of the fundamental structures effortlessly identified by the brain (shapes, objects, auditory or tactile categories). I here propose to establish a new approach combining high-throughput population recoding methods with a tailored theoretical framework to derive computational principles operating throughout sensory systems and leading to biologically structured perception. This approach follows on the recent mathematical proposal, suggested by Deep Machine Learning methods, that complex perceptual objects emerge through series of simple nonlinear operations combining increasingly complex sensory features along the sensory pathways. Starting with the mouse auditory system as a model pathway, we will recursively extract, with model-free methods, the main nonlinear sensory features encoded in genetically tagged output and local neurons at different processing stages, using optical and electrophysiological high density recording techniques in awake animals. The role of these features in perception will be identified with behavioural assays. Specific intra- and interareal feedback connections, typically not included in Deep Leaning models, will be opto- and chemogenetically perturbed to assess their contribution to precise nonlinearities of the system and their role in the emergence of complex perceptual structures. Based on these structural, functional and perturbation data, a new generation of well-constrained and predictive sensory processing models will be built, serving as a platform to extract general computational principles missing to link neural activity to perception and to fuel artificial neural networks technologies.
HIGH-PHOSPHOROUS ELECTROLESS NICKEL (HPEN) TREATMENT FOR BUSHINGLESS CONNECTING ROD

A method for treating a bushingless connecting rod (120), wherein the bushingless connecting rod comprises an elongated rod having a pin end configured to connect with a piston (111), and a crank end configured to connect with a crankshaft. The pin end includes a bore (200) with an internal diameter. The method includes cleaning the pin end bore, masking and fixturing the pin end bore with elastomeric separators, and providing a high-phosphorous nickel alloy coating on the internal diameter of the pin end bore. The method may be applied to original equipment or to a worn engine undergoing a remanufacturing process.
Protecting European Biodiversity from Invasive Alien Species

IMPROVING POLICIES TO PROTECT BIODIVESRITY FROM INVASIVE ALIEN SPECIES:
Biological invasions are considered to be one of the greatest threats to the biodiversity and natural ecosystems. Invasive Alien Species (IAS) can act as vectors for new diseases, cause native species’ extinction, change ecosystem processes, and reduce the value of land and water for human activities. 
INVALIS will enable the participating territorial authorities to address common challenges associated with biological invasions such as a) knowledge gaps in ecosystems’ vulnerability to biological invasions and species’ distribution, b) lack of awareness about IAS environmental and socioeconomic risks, c) low level of cooperation between public authorities and key stakeholders for the implementation of IAS management measures, and c) conflicts of interests. 

OBJECTIVE:
INVALIS brings together 7 partners from 7 countries, to improve their environmental policies, by supporting policy measures for the prevention, early detection and control of IAS. 

EXPECTED IMPACT:
- Increased capacity of 200 staff of public administrations to effectively implement IAS management policies.
- 10 million euros unlocked to support projects for increasing natural ecosystems’ resilience to IAS and to carry out eradication/control actions for high priority species.
- Increased awareness of over 1000 stakeholders about IAS impact on the biodiversity, economy and human health.

MAIN OUTPUTS & BENEFICIAIRIES:
- 6 action plans to improve the addressed policy instruments, benefiting managing authorities and beneficiaries.
- 3 interregional workshops, 2 site visits and 1 EU-wide policy learning event to promote capacity building among partners and stakeholders .
- 18 policy briefs to transfer INVALIS lessons learnt to EU public authorities. 
- A risk assessment framework for EU public administrations to assess regional ecosystems’ vulnerability to IAS.
- 4 baseline analysis reports on territorial needs and IAS management practices.
Защитная решетка радиатора бронированной машины

Полезная модель относится к области бронированных машин, в частности, к устройствам для защиты элементов системы охлаждения двигателя и подкапотного пространства автомобиля от пуль и осколков снарядов.Технический результат, на достижение которого направлено данное техническое решение, заключается в повышении надежности защиты радиатора от рикошета пуль или осколков от поверхности наклонных броневых пластин.Технический результат, на достижение которого направлено данное техническое решение, заключается в повышении надежности защиты радиатора от рикошета поражающих элементов, от тыльных сторон наклонных пластин и передних поверхностей близкорасположенных дополнительных пластин.Указанный результат достигается тем, что защитная решетка радиатора бронированной машины, содержащая боковые стенки, установленные между ними наклонные пластины с выступами в верхней части и дополнительные пластины, соединяющие выступы с нижними частями наклонных пластин, в нижней своей части снабжены изгибами, которые охватывают нижние части наклонных пластин, причем с тыльной стороны верхней части наклонных пластинах выполнены выступы, перекрывающие сектора вероятного движения поражающих элементов между тыльными сторонами наклонных пластин и передними поверхностями близкорасположенных дополнительных пластин, при этом выступы с лицевой стороны верхней части наклонных пластин выполнены под острым углом к наклонным пластинам, а дополнительные пластины в верхней части наклонных пластин перекрывают выступы с лицевой и тыльной стороны верхней части наклонных пластин и снабжены изгибами, выступающими за кромки выступов, выполненных с тыльной стороны верхней части наклонных пластин.
After the “honeymoon”, what is next? COVID‐19 policies in Europe beyond the first wave

This special issue is the sequelto the issue on COVID-19 policies published in European Policy Analysis in fall 2020, which focused on the European countries' early responses to the pandemic. The collection aims to go beyond the "honeymoon" phase of the outbreak, that is, the first wave. The selected cases-Sweden, Greece and Cyprus, Germany, Turkey, Hungary, and the Eurozone-provide a variety of national features in terms of political systems, institutional structures, and policy styles. The featured articles adopt different theoretical perspectives and are authored by scholars from a variety of disciplines, who pursue both interpretative and explanatory goals by focusing on policy adoption, policy perception, and learning opportunities, but also on local pandemic management and policy outcomes. A fil rouge unites the featured contributions: they all show the importance of analyzing change over sufficiently long timeframes, to capture the complexity of existing trends.本期特刊是继2020年秋季《欧洲政策分析》发表的2019冠状病毒病（COVID‐19）政策特刊的延续，后者聚焦于欧洲国家对大流行的早期响应。本期特刊旨在探究病毒爆发“蜜月”阶段（即第一波新冠疫情）之后的发展。选定的案例——瑞典、希腊和塞浦路斯、德国、土耳其、匈牙利以及欧元区——在政治制度、制度结构和政策风格方面提供了一系列国家特征。专题文章采用不同的理论视角，由来自不同学科的学者撰写，他们通过聚焦于政策采纳、政策感知和学习机会，以及当地的大流行管理和政策成果来追求诠释性和解释性目标。将这些专题文章结合在一起的中心主题则是:这些文章都表明了在足够长的时间范围内分析变化的重要性，以期描述现有趋势的复杂性。.Este número especial es la continuación del número sobre las políticas de COVID‐19 publicado en European Policy Analysis en el otoño de 2020, que se centró en las primeras respuestas de los países europeos a la pandemia. La colección pretende ir más allá de la fase de “luna de miel” del brote, es decir, la primera ola. Los casos seleccionados (Suecia, Grecia y Chipre, Alemania, Turquía, Hungría y la Eurozona) brindan una variedad de características nacionales en términos de sistemas políticos, estructuras institucionales y estilos de políticas. Los artículos presentados adoptan diferentes perspectivas teóricas y están escritos por académicos de una variedad de disciplinas, que persiguen objetivos interpretativos y explicativos centrándose en la adopción de políticas, la percepción de políticas y las oportunidades de aprendizaje, pero también en la gestión local de pandemias y los resultados de las políticas. Un fil rouge une las contribuciones destacadas: todas muestran la importancia de analizar el cambio durante períodos de tiempo suficientemente largos, para capturar la complejidad de las tendencias existentes.
Built environment knowledge for resilient, sustainable communities: understanding everyday modern architecture and urban design in the iberian peninsula (1939-1985)

How can we manage, improve and develop resilient, sustainable communities, without a solid scientific knowledge of our built environment? Our everyday life is framed by a cohort of buildings about which we know very little, or nothing: they are outside of our cultural concerns, even though we reside, work, learn or convalesce in them. Understanding the architecture that shapes our everyday empowers our communities – it enables them to take informed decisions about what to preserve, reuse and replace; how to update and improve their buildings. At a time when resources are dwindling and must be used rationally, repurposing and retrofitting existing buildings is a priority over new construction, everywhere. European societies have a vast building stock at their disposal, erected in the second half of the past century, to be used and transformed: sturdy, pragmatic objects whose features are seldom discussed.
ReARQ.IB bridges the gap between local communities in Spain and Portugal and their ‘architecture of proximity’: structures, ensembles and neighbourhoods generally left out of canonical historiography, close to our lives but far from our minds. Making the genetic fabric of this built environment clear, intelligible and operative is an essential first step for responsible management and decision-making by stakeholders. Contemporary architecture in both countries may be celebrated in professional circles, and even enjoy public visibility – but communities across the Iberian Peninsula, including many designers, know precious little about their modern built environment, which grew exponentially in the 20th century. Focusing on public-use and residential buildings – prevalent generic typologies that concern most communities – ReARQ.IB will integrate information and critical enquiry to support management and action while advancing architectural and urban history. This is applied science for community participation enabling a more sustainable and resilient built environment
Wheat yield response to input and socioeconomic factors under changing climate: Evidence from rainfed environments of Pakistan

More than three-quarters of the world's total cultivated land is under rainfed farming, producing almost 70% of total food. Most food production comes from developing and least favored nations. Pakistan, a developing country with an agro-based economy, is facing severe threats from climate change. Rainfed agriculture, especially wheat farming, is highly susceptible due to its heavy dependency on precipitation, one of the most important climatic parameters. Wheat is the main food crop, as well as a major source of calorific intake, for millions of people in Pakistan. This study aims to quantify the impacts of climate variability on mean yield levels and yield variability of wheat crop in the rainfed zone of Pakistan. Multistage random sampling technique is used for primary data collection from 400 rainfed wheat farmers during the 2016-17 crop season. The study uses primary data on crop input-output, management, socioeconomic, institutional, and historical climatic data (1980-2017). The data are analyzed employing the Just and Pope (J-P) stochastic production function approach with linear and non-linear functional forms. The results reveal that temperature rise negatively affects observed wheat mean yields, while cumulative precipitation positively affected it. Further, input market access, seed rate, and cumulative precipitation also cause variability in yield levels, leading to yield instability. Further, farm elevation influences wheat mean yield positively while input market access influences it negatively. The findings of the study have important implications for climate resilient wheat farming. Timely and tailor-made adaptations need to be undertaken in the rainfed wheat farming systems of Pakistan. Creating awareness among farmers about the optimal use of agronomic inputs under changing climatic conditions could be an effective adaptation strategy that improves yields and copes with yield instability.
Identification of phosphorylated proteins involved in the oncogenesis of prostate cancer via Pin1-proteomic analysis

The peptidyl-prolyl isomerase Pin1 regulates a subset of phosphorylated proteins by catalyzing the cis-trans isomerization of their specific phosphorylated Ser/Thr-Pro motifs. Although Pin1 has been shown to be involved in cell transformation and the maintenance of the malignant phenotype in prostate cancer, its specific substrates during these processes have not yet been determined.Cancer-specific phosphorylated proteins were isolated from two human prostate cancer cell lines (PC-3, LNCaP) and the Dunning rat prostate cancer cell lines by GST-pull down analysis with recombinant GST-Pin1 protein. These proteins were then identified by the LC-MS/MS analysis using a Q-Tof micro mass spectrometer and processed for further functional analysis.We newly identified five prostate cancer-specific Pin1 binding proteins (PINBPs) in this screen. Among these, TRK-fused gene (TFG) was found to be preferentially up-regulated in prostate cancer cell lines and tissues. The targeted inhibition of TFG by specific siRNA resulted in the reduced cell proliferation and the induction of premature senescence in PC3 prostate cancer cells. We further found that TFG can facilitate the cell signaling mediated by NF-kappaB and androgen receptor (AR). Tissue micro-dissection based quantitative RT-PCR analysis of prostate cancer tissues following radical prostatectomy further revealed that TFG expression is closely associated with both a higher probability and shorter period of tumor recurrence following surgery.Pin1-based proteomics analysis is a useful tool for the identification of prostate cancer-specific phosphorylated proteins. TFG could be a potential diagnostic and/or prognostic marker and therapeutic target in prostate cancer.
INTEGRATED TECHNIQUES FOR PRODUCING BIO-METHANOL

Methods and systems for producing bio-methanol can include anaerobic digestion of a biomass feedstock to produce biogas including methane and carbon dioxide, partial oxidation of the biogas with oxygen from water electrolysis to produce syngas, synthesizing bio-methanol from the syngas and hydrogen from the water electrolysis, storing the bio-methanol during off-peak electricity demand, intermittently generating electricity from the bio-methanol during peak electricity demand and using such electricity for the water electrolysis. The techniques provide a route for the production of bio-methanol without the engagement of fossil fuels as feedstocks and mitigating fossil fuel derived greenhouse gas emissions from processing and utilization of transportation fuels and commercial or industrial alcohols.