SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Multiple designer organelles for expanded eukaryotic life

The emergence of organelles dedicated to specific cellular functions drove the evolution of more complex eukaryotic organisms. We recently created membraneless organelles inside eukaryotic cells dedicated to orthogonal translation, which opened a new path to residue-specific protein engineering using genetic code expansion. We now want to design novel organelles into eukaryotes that will internally enact the entire central dogma of molecular biology. This will supplement the complex eukaryotic cell with an additional simple and easily tailored orthogonal machinery that can also facilitate transcription and replication. This will enable us to create eukaryotes that have more than four additional expanded genetic codes, and we will explore the functional space occupied by these novel living systems. The organelles will be enhanced to process specific signals to e.g. modify RNA or degrade specific proteins. Besides these curiosity-driven goals, specific applications will allow us to road test our technology. We will directly use these approaches to advance protein engineering in eukaryotes to create proteins and artificial peptide polymers having multiple, noncanonical functionalities suitable for diverse biotechnological applications and new bioinspired materials. We will also develop organelle design into a truly universal and powerful labeling method fully compatible with eukaryotic host cell physiology that has single-residue precision and goes way beyond the state-of-the-art of any fluorescent labeling technology. The approaches will be general and truly flexible in how translation can be tailored in terms of protein, RNA and codon choice, including sense codons and type of new functionalities. Progress made in recent decades has shown that protein design and engineering can revolutionize biology. We can only imagine what can be achieved with designed functional organelles inside eukaryotic cells and how they might enable the creation of new living systems.
D &B S.R.L.

A EMPRESA ‘D&B S.R.L.’ foi construída em 14.12.2014 com ato notarial da TIZIANA BOTTARO NOTARY IN GENOVA. A ESTRUTURA SOCIAL É COMPOSTA POR 20 % DO PESSOAL DA EMPRESA. LUCA DOOU 80 % PELA SIG.RA ISABELLA BONETTI. A EMPRESA ESTÁ SEDIADA EM GÉNOVA VIA FIESCHI 3/9 EM UMA PROPRIEDADE COM CONTRATO DE ALUGUEL REGULAR LOCALIZADO EM UMA POSIÇÃO ALTAMENTE FAVORÁVEL PARA O SEU NEGÓCIO. A EMPRESA REALIZA A ATIVIDADE DE PROCESSAMENTO DE DADOS CONTÁBEIS EM NOME DE TERCEIROS, NEGÓCIOS, CONSULTORIA CORPORATIVA, DE GESTÃO E FISCAL, A EXECUÇÃO DE ESTUDOS DE MERCADO, INCLUINDO SERVIÇOS RELACIONADOS COM QUESTÕES DE MARKETING, INCLUINDO OS VÁRIOS SERVIÇOS DE APOIO ÀS EMPRESAS. NA EMPRESA ATUALMENTE TRABALHAM 5 FUNCIONÁRIOS COM CONTRATO POR TEMPO INDETERMINADO QUE, JUNTAMENTE COM OS FUNCIONÁRIOS, ESTÃO ENVOLVIDOS NA CONTABILIDADE ADMINISTRATIVA E ASSESSORIA FINANCEIRA DAS EMPRESAS. O SERVIÇO oferecido a partir de D&B SRL VERTE NO VULTURO PARA OS SEUS CLIENTES Um PACC
OPERATING UNIT AND PAIRING METHOD FOR AN OPERATING UNIT

The invention relates to a pairing method for establishing a radio link between a mobile operating unit and a remote device (6), wherein the operating unit has at least one switch, the switching state of which is transferred to the remote device in an operating mode of the operating unit. The invention is characterized by the following steps: determining a location of the operating unit which deviates from an operating location of the operating unit in the operating state; assuming a pairing mode of the operating unit, in which pairing with the remote device is possible if the deviating location is detected and if an activation of an operating element is detected; and assuming the operating mode of the operating unit if the pairing has been carried out. The invention further relates to an operating unit having at least one switch, the switching state of which can be transmitted via a radio module to a remote device (6) in an operating mode of the operating unit, and which has a location and/or acceleration sensor, by means of which a location of the operating unit that deviates from an operating location can be detected. The operating unit is distinguished by the fact that the operating unit is configured to perform such a pairing method.
Effects of a single prolonged milking interval in cows

A single prolonged milking interval (PMI), such as might be associated with technical
failures in automatic milking systems, leads to a subsequent somatic cell count (SCC)
peak in bulk tank milk. Increased SCC indicates mastitis in cows. It is generally
correlated with reduced milk yield and quality, and is often used as a criterion for milk
payment. Whether the transient SCC peak after a single PMI affects yield and quality is
not known. The short duration of the inflammatory reaction after a PMI and its nonpathological
history raise questions about the underlying immunological mechanisms
and possible role of immunocompetent natural milk components. It is important to
learn more about this kind of physiological inflammation to improve the interpretation
of SCC and the general understanding of udder immunology. This thesis investigated
the inflammatory reaction after a single PMI of 24 h at both the cow and the quarter
level, and how it influences milk yield and quality.

The PMI appeared to induce temporarily impaired epithelial integrity but no
epithelial damage. Even so,milk yield per cow was reduced with 0.75 kg/day after the
PMI, notably for up to the 10 days studied. Thus, based on the long-lasting reduction in
yield and a possibly reduced milk payment due to the SCC peak, a PMI is of significant
economic concern for the farmer although milk quality itself was shown not to be
afflicted.

The PMI caused a two-fold increase in the SCC, which then remained elevated for 2
days and was associated with an increased proportion of polymorphonuclear leukocytes
(PMN) in milk. The most pronounced SCC reaction after the PMI was not seen until
the udder had been emptied once. The initiation of inflammation occurred first during
the PMI and elicited a systemic acute phase response of serum amyloid A (SAA),
observed in blood prior to its appearance in milk. The milk showed consistently high
chemotactic activity in vitro, although no increased content of the cytokines IL-1β and
IL-8 was detected. The PMI induced significant alterations in the content of α-lactalbumin (ALA) and prolactin (PRL), in relation to the PMN reaction. ALA
inhibited and PRL stimulated PMN migration, when tested in vitro. Based on the
findings in this thesis, it is probable that SAA played a significant role in the
inflammatory reaction after a PMI but it cannot be excluded that ALA and PRL might
also have been contributing factors.
The unconventional hydrocarbon resources of Greece

Intensive exploration of probable conventional hydrocarbon reservoirs in Greece is taking place, through the interpretation of seismic profiles and of abundant surface geological data. The unconventional hydrocarbon potential of the country is unknown, as detailed investigations are lacking. The most important rock formations which may contain shale gas are found in the land and offshore basins of northeastern, north-central, and western Greece. A re-evaluation of the data from all boreholes is needed, on the basis of new information, with the aim of identifying possible reserves of unconventional hydrocarbons retained in highly compacted fine-grained strata. Methane hydrates have been detected in the submarine Anaximander Mountains, east of Rhodes Island. They cover an area of about 46 km 2 and the volume of methane is estimated at 2.6–6.4 trillion m 3 . The low content of the Greek lignites in gaseous hydrocarbons and the widespread tectonics in the Hellenic Peninsula are the main factors which prevented large gas accumulations in its 14 main coal deposits. However, additional research is needed to evaluate the coal-bed gas potential of the country.
Protect traditional built heritage skills – pro-heritage

According to the climate change and energy policy of the EU, each member state needed to identify and develop a series of energy efficient goals and regulations, of which buildings are a key element, in order to reach the set goals. However, Europe has numerous historic buildings, which need permanent maintenance and refurbishment in order to fulfil the requirements of sustainability and use.
When responsible bodies do spend money anyway, it seems logical and ecologically worthwhile to apply “soft” maintenance procedures, which save costs and also reduce energy consumption of historic buildings. Integrating these buildings into national climate change and energy policies seems therefore quite necessary and a challenge, as far as appropriate techniques and procedures are concerned, which can only be met through excellently trained craftsmen and apprentices of the crafts concerned.
PRO-Heritage partners aim to offer initial and permanent education for professionals and craftsmen providing traditional competences and skills for built heritage, based on Best Practice of partner organisations. Additionally, PRO-Heritage is going to establish a structure and environment for regular journeyman's travel in Europe, in order to further support the exchange of competences and skills across Europe.
Major needs addressed in PRO-Heritage are 
• to protect traditional competences and skills for built Cultural Heritage relevant for energy efficiency and renewable energy
• the need to involve adequately educated and trained professionals and craftsmen in “soft” conservation, maintenance and ongoing care
• the need to certify those professionals and craftsmen in order to give them recognition of their competences and skills
Achieving better energy performance in historic buildings is a WIN-WIN situation for all – owners facing less energy costs, residents enjoying modern comfort at reasonable prices and society reducing energy consumption and CO2 emission.
Perfect state transfer over interacting boson networks associated with group schemes

It is shown how to perfectly transfer an arbitrary qudit state in interacting boson networks. By defining a family of Hamiltonians related to Bose-Hubbard model, we describe a possible method for state transfer through bosonic atoms trapped in these networks with different kinds of coupling strengths between them. Particularly, by taking the underlying networks of so called group schemes as interacting boson networks, we show how choose suitable coupling strengths between the nodes, in order that an arbitrary qudit state be transferred from one node to its antipode, perfectly. In fact, by employing the group theory properties of these networks, an explicit formula for suitable coupling strengths has been given in order that perfect state transfer (PST) be achieved. Finally, as examples, PST on the underlying networks associated with cyclic group C 2m , dihedral group D 2n , Clifford group CL(n), and the groups U 6n and V 8n has been considered in details.
Non-Invasive clinical markers for diagnosis of endometriosis

Endometriosis is a chronic disease that affects 10% of all women of reproductive age. It is characterized by the ectopic growth of endometrial tissue outside the uterus and is a major cause of pelvic pain and disability. Endometriosis also has an adverse effect on fertility, with almost one third of patients failing to conceive. The aetiology of endometriosis is unknown and a definitive diagnosis of endometriosis requires invasive laparoscopic surgery, and treatment options are limited in number and efficacy. This research proposal will adopt an integrated, systems biology approach to finely characterize how circulating and local uterine glycoprotein profiles are altered in endometriosis, and how such profiles may be influenced by dysbiosis of the uterine microbial ecosystem including possible intracellular pathogen infection. Using our combined multidisciplinary expertise in glycomics, microbiome and gynaecology, we will use findings from this study to define how changes in glycosylation pattern and microbial profile that are associated with endometriosis may be developed as novel, non-invasive diagnostic markers for the disease. It may also provide insight into disease pathogenesis. Accurate diagnosis and effective treatment of endometriosis has the potential to significantly reduce the healthcare cost burden associated with current strategies and may increase success rates of pregnancy and live births in these patients. This collaborative translational research project will be primarily based at NIBRT (SME, host institution), with secondments in APC Microbiome Institute, University College Cork (UCC), and also at the Merrion Fertility Clinic (MFC) and University College Dublin Centre for Support and Training in Analysis and Research (UCD CSTAR).
RESTRICTED DOMAIN MALAY SPEECH SYNTHESIZER USING SYNTAX-PROSODY REPRESENTATION

The speech synthesis approach required in restricted domain speech application is a synthesizer that has high quality like the speech output of ‘slot-filler’ approach but have at least the least flexibility of the ‘genuine’ speech synthesizer. Thus, in this research study, we propose an alternative approach of creating a speech synthesizer to be used in a restricted domain speech application. In our approach, we use word unit as the primary unit and our speech corpus is represented by syntax-prosody tree structures. Speech synthesis is performed by constructing a syntax-prosody tree of a target input sentence. The construction of the tree is by done by adapting an example-based syntactic parsing approach and the concatenated of synthesis units from the constructed tree nodes will be the synthesized utterance. For evaluation, we performed MOS subjective evaluation on our speech synthesizer with natural speech and two other Malay TTS system. Based on an ANOVA and T-Tests analysis, we found the overall MOS scores of our speech synthesizer output, sound B was (mean = 3.34, sd = 1.10), the other two Malay TTS system; C (mean = 1.95, sd = 0.72) and D (mean = 1.80, sd = 1.04) and the natural speech, A (mean = 4.71, sd = 0.21). We conclude that our Malay speech synthesizer sounded more natural, easier to listen, more pleasant and more fluent compared to the sounds of the other two Malay TTS systems. As expected, the recorded speech was perceived more natural than the output of our Malay speech synthesizer.
Reinforced Soil Salinization with Distance Along the River: A Case Study on the Yellow River

Clarifying the relationship between salt-affected soils and their adjacent river systems is critical to alleviate the challenges posed by soil salinization on agricultural production. Among the various biophysical and land management factors linked to soil salinization, very few studies have addressed what is intuitively a fundamental parameter: the distance along the river. Using the Hetao Irrigation District on the Yellow River as a case study, we collected and analyzed over 5300 soil samples and 17 soil parameters to provide more in-depth insight into the relationship between salt-affected soils and their distance along the river. Soil salinization was reinforced by the distance along the river, as a trade-off between ion accumulation and soil nutrient regulation. With every kilometer along the river, soil exchangeable sodium and cation exchange capacity increased by 8.89×10 -4 and 1.26×10 -2 cmol kg -1 , respectively, which led to an increase in exchangeable sodium percentage by 9.59×10 -5 . The increase in exchangeable sodium along the river was mainly due to Na + accumulation from upstream to downstream. Soil pH increased by 1.21×10 -3 , while soil total water-soluble salt content increased by 16.4 mg kg -1 every kilometer. This increase in salt content is likely due to ions leaching from the soils upstream and partially accumulating in the soils downstream, especially for Cl - , SO 4 2- , and Na + . Greater organic inputs on the less salt-affected soils upstream may explain the slight decline in soil organic matter with distance along the river. Future saline soil amelioration for reutilization initiatives at regional scales will benefit from accounting for the changes in soil physicochemical properties resulting from the distance along the river.
METHOD AND APPARATUS FOR ALIGNMENT OF AN OPTICAL ASSEMBLY WITH AN IMAGE SENSOR

A method is described for positioning an image sensor at a point of best focus for a lens. The lens has an optical axis and the image sensor is moved to a plurality of positions along the optical axis. The image sensor captures an image of a target image at each of the plurality of positions through the lens. A measure of blur in the image captured is derived at each of the plurality of positions from pixel data output from the image sensor. A relationship is derived between blur and position of the image sensor along the optical axis. The image sensor is then moved to a position on the optical axis that the relationship indicates as the point of best focus where the image sensor is fixedly secured relative to the lens.
On the New Passive

The so-called New Passive in Icelandic takes the form 'it was elected us' (or, e.g., 'then was elected us', without an expletive), instead of the standard form 'we were elected'. It has neither A-movement to subject nor acc-to-nom conversion, which are otherwise diagnostic of the canonical in Icelandic and related languages. Some researchers have argued that passive is in fact a misnomer and that the construction should instead be analyzed as an active one, with a nominative pro. This paper argues instead in favor of a minimalist analysis, where the New Passive is closely related to the impersonal P (with a PP, type 'then was shouted at us'), which is highly common and productive in Icelandic. On the approach pursued, acc-to-nom conversion involves case-star deletion, absent from the New Passive (much as from so-called psych and fate (un)accusatives in standard Icelandic). Additionally, the New Passive has a strong vP phase edge, blocking A-movement, in contrast to the defective vP edge in the canonical passive. The paper argues that A-grounding or freezing is brought about by phi-minimality, A-islands thus arising in a parallel fashion with A'-islands. (Less)
Assessment of river encroachment and land-use patterns in Dhaka city and its peripheral rivers using GIS techniques

After 70’s decade Dhaka city started as a densely populated mega city with high land scarcity for its ever growing population. Some opportunistic people take this advantage and make illegal constructions over the bank of river. These illegal constructions are increasing day by day and now turn into a sore called river encroachment. As a result, Dhaka city has been suffering from many socio-environmental problems including flooding, water logging and other related problems. The present study was conducted to assess the areas of illegal intrusion of navigable rivers and its canals over the period of 2001 to 2014, and unsupervised image classification was performed over the area of 200 meters by using the Arc GIS 10.1 and Google earth software, which is focused on different criteria. Rapid river encroachment has been observed in many places of Dhaka city and its peripheral river's corridor. The order of encroached rivers was: Turag (Abdullahpur > Gabtoli), 120.7943 acres > Buriganga (Kamrangirchar > Bosila), 97.1697 acres > Sitallakhya (Katchpur > Narayangang), 23.8315 acres > Balu (Demra > Nandipara), 8.8424 acres within an area of 5.7581 miles, 7.4120 miles, 3.5679 miles and 4.2032 miles respectively. By ISO unsupervised image classification it was observed that the area was mostly encroached by human settlement and infrastructure. It was alarming that the infrastructure level in the study area of 2014 was several times higher when it is compared to the infrastructure level of 2001. The greatest percentages of infrastructures were built on the bank of Buriganga River in Bosila (56.10%) and the lowest percentages of infrastructures were built on the Balu River in Nandipara (1.77%). Not only these rivers, but also the Turag, and Sitallakhya River are also narrowing day by day. Due to the rising of illegal infrastructures and human settlement, the water bodies, barren lands, croplands and vegetation decreased significantly in the encroached areas.
The impact of infectious diseases consultation on oncology practice

Traditional utilization of infectious diseases consultants by oncologists ranges from inpatient management of a variety of acute infectious syndromes to management of ambulatory patients with acute or chronic infections; however, there is a paucity of data to evaluate in which circumstances the impact of infectious diseases input may be most valuable.Data derived from the general population of patients emphasize the value of infectious diseases consultation in specific infections, such as Staphylococcus aureus bacteremia, candidemia, and hepatitis C virus infection. In addition, infectious diseases involvement has been associated with greater adherence to guidelines (up to 34% increase), more appropriate antibiotic utilization (up to 52% increase in appropriate duration), decreased cost and complications of care, and lower mortality (up to 17% decrease). Recent studies suggest that bedside, formal infectious diseases consultation is more optimal than informal interactions (e.g., e-mail, telephone, other). Furthermore, infectious diseases consultants play central roles in antibiotic stewardship, infection control, and quality improvement, particularly in oncology centers.Infectious diseases consultants contribute value in various inpatient and outpatient infections, decreasing mortality, cost, and complications.
PHASE CONJUGATE RELAY MIRROR APPARATUS FOR HIGH ENERGY LASER SYSTEM AND METHOD

A system (500) for directing electromagnetic energy. The inventive system includes a first subsystem mounted on a first platform (520) for transmitting a beam of the electromagnetic energy through a medium and a second subsystem mounted on a second platform (510) for redirecting the beam (503). In accordance with the invention, the second platform (510) is mobile relative to the first platform (520). In the illustrative embodiment, the beam is a high-energy laser beam (503). The first subsystem includes a phase conjugate mirror (510) in optical alignment with a laser amplifier (514). The first subsystem further includes a beam director (522) in optical alignment with the amplifier (514) and a platform track sensor (524) coupled thereto. In the illustrative embodiment, the second subsystem includes a co-aligned master oscillator (502), outcoupler 504, and target track sensor (506) which are fixedly mounted to a stabilized platform (507), a beam director (508), and a platform track sensor (509). In the best mode, the stable platform (507) is mounted for independent articulation relative to the beam director (508). A first alternative embodiment of the second subsystem includes first and second beam directors (508, 610). The first beam director is adapted to receive the transmitted beam and the second beam director is adapted to redirect the received beam. In accordance with a second alternative embodiment, an optical fiber (710) is provided for coupling the beam between the first platform (520) and the second platform (510).
SAMPLE CHAMBER ASSEMBLY AND METHODS

An apparatus comprising a fluid communication device, a sample chamber, and a coupling assembly. The fluid communication device is operable to establish fluid communication between a downhole tool and a subterranean formation penetrated by a wellbore in which the downhole tool is positioned. The sample chamber is in selectable fluid communication with the formation via the fluid communication device. The coupling assembly mechanically couples the sample chamber within the downhole tool and comprises a cam rotatable between a first position and a second position, wherein the cam preloads the sample chamber when in the first position is disengaged from the sample chamber in the second position.