SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
[A case of intrahepatic cholangiocarcinoma with peritoneal dissemination treated successfully with surgical resection and adjuvant chemotherapy].

A 72-year-old woman was diagnosed with liver dysfunction during a medical examination. An abdominal computed tomography (CT) scan showed multiple nodules in the left lobe, anterior segment, andposterior segment of the liver, leading to a diagnosis of intrahepatic cholangiocarcinoma (ICC). Extended left lobectomy and partial hepatectomy in the anterior and posterior segment with lymph node dissection was performed. At the time of the operation, small nodules on the peritoneum near the stomach were resected; these nodules were diagnosed as peritoneal disseminations of ICC. The histopathological diagnosis was moderately differentiated tubular adenocarcinoma (T4N0M1, Stage IVB). Adjuvant chemotherapy with S-1 was administered for 18 months. Thirty months after the operation, multiple lung metastases were detected by using CT, and chemotherapy with gemcitabine was initiated. Thirty-six months after chemotherapy with gemcitabine, the patient is alive and at home despite her lung metastases, which grew slightly in size. Herein, we report a long-term survival case of ICC with peritoneal dissemination that was successfully treated with surgical resection and adjuvant chemotherapy.
The travelling astronomers. international collaborations after world war ii and the reorganization of european astronomy (1953-1985)

This research project investigates the history of astronomy in Europe after World War II. In the period between 1953 and 1985, a number of international collaborations were undertaken by several European countries, with the aim of strengthening astronomical research in terms of its capacity and facilities. These collaborations culminated in the construction of powerful observational facilities and the implementation of programmes for cooperation in professional research. In this respect, the initiatives taken from 1953 to 1985 inaugurated a new era of European astronomy. Indeed, in this period research facilities were made available in both hemispheres, new research networks were created, and there was a new attitude towards scientific cooperation.
This study will analyse crucial aspects of the development of astronomy in post-war Europe. More specifically, this research will address the interactions among astronomers, scientific institutions, and governments in the light of the quest of new astronomical sites; the connections between scientific, technical, political, and economic issues in the foundation of new astronomical observatories; and the changes in the community of professional astronomers, both in terms of  research practice and social organization. Consequently, this study will contribute to elucidate the reorganization of astronomy in post-war Europe. Moreover, it will reinforce the comprehension of the development of scientific research, science policy and international scientific cooperation.
Public Sector Financial Management Reform: A Case Study of Local Government Agencies in Indonesia

Indonesia has taken initiatives to reform its public sector financial management. One of the reform agendas was to introduce ‘cash to accrual’ accounting for improved financial reporting. It is expected that improved financial reporting will enhance financial accountabilities of the governmental agencies and will assist both internal and external decision makers whose decisions will be based on the financial reports. However, it has been observed that there is a significant increase in the number of qualified audit reports when these financial reports were audited. This also means that these financial reports are lacking in providing true and fair views on the financial activities of the governmental agencies, thereby not assisting in discharging their accountabilities. This study seeks to answer the question as to why the numbers of qualified audit reports have increased despite the existence of various governmental accounting reform agendas. Based on the in-depth case studies of three Indonesian local governments, it is found that the demand, the supply and the quality assurance of the accounting information outputs in these local governments are not in parity, and this lacking in parties actually has impacted in producing unqualified and usable accounting reports.
Assessing the socio-economic impact of environmentally sustainable redevelopment plans on communities housed in social housing estates in eu and us cities

Over the last decade, a new field of studies on ‘green gentrification’ has suggested a causal correlation between the implementation of environmentally sustainable planning initiatives and the displacement of low-income residents due to changes in property values resulting from environmental improvements. Such patterns are particularly alarming when 'green' development initiatives are implemented in disadvantaged neighborhoods with a history of concentrated poverty and social marginalization. In this comparative interdisciplinary study I will add to this growing body of literature by investigating the impact of 'green' redevelopment plans on the communities housed in three social housing estates in Europe and the US. I will conduct research in three cities –Berlin, London and Los Angeles – where three social housing estates, home to poor and marginalized communities, have been recently redeveloped as eco-friendly urban districts. My aim is to assess the extent to which these plans have encouraged processes of residential displacement of vulnerable households, including minorities and women, and if and what actions have been put in place to prevent them. My research objectives (RO) are: to examine the different politico-institutional landscapes in which the 'green' plans identified have been developed and operate in (RO1); to document the three redevelopment projects and the planning toolkits in use in each specific context (RO2); to quantify the socio-demographic impact of redevelopment, documenting residential turnover (RO3); to qualify the social impacts on the pre-existing public housing tenants through in-depth qualitative research (RO4). By shedding light on the dynamics of gentrification and displacement that may arise in social housing estates undergoing 'green' development, this research will provide an evidence base for policy making and encourage the design and implementation of equitable public policies that might counter unintended negative outcomes.
Approximate Bisimulation: A Bridge Between Computer Science and Control Theory

Fifty years ago, control and computing were part of a broader system science. After a long period of separate development within each discipline, embedded and hybrid systems have challenged us to reunite the, now sophisticated theories of continuous control and discrete computing on a broader system theoretic basis. In this paper, we present a framework of system approximation that applies to both discrete and continuous systems. We deﬁne a hierarchy of approximation metrics between two systems that quantify the quality of the approximation, and capture the established notions in computer science as zero sections. The central notions in this framework are that of approximate simulation and bisimulation relations and their functional characterizations called simulation and bisimulation functions and deﬁned by Lyapunov-type inequalities. In particular, these functions can provide computable upper-bounds on the approximation metrics by solving a static game. Our approximation framework will be illustrated by showing some of its applications in various problems such as reachability analysis of continuous systems and hybrid systems, approximation of continuous and hybrid systems by discrete systems, hierarchical control design, and simulation-based approaches to veriﬁcation of continuous and hybrid systems.
Revisiting the Borrobol Tephra

The study of palaeoclimates, especially the rapid climate changes during the Last Glacial-Interglacial Transition (LGIT ca. 15-8 ka BP), requires precise dating as well as the ability to link climate records over large regional areas. As has recently been demonstrated by the Eyjafjallajokull eruption, volcanic ash (tephra) has the possibility of a widespread geographical distribution which for geological purposes is instantaneous. Tephrochronology, the study of volcanic ash as a geochronological method, has over the past few decades developed methods to identify distal cryptotephras, tephras invisible to the naked eye. This has expanded the number of maker horizons as well as the areas in which they can be found. The studies presented here expand the geographical extent of one marker horizon, the Hasseldalen Tephra, in Southern Sweden. At the same time, some of the problems of the method are examined. The method builds on horizons being distinct and geochemically fingerprinted. The Borrobol Tephra has been found in Scotland and Sweden but with widely differing dates leading to the possibility of there actually being two geochemically identical horizons in close stratigraphic proximity. The present studies provide new results from the original type-site as well as reanalysis of the geochemistry of shards from the first Swedish findings. The major element analysis used here reflects improvements in Electron Probe Microanalysis (EPMA) settings which provides more robust data with slightly altered values from those previously published. These altered values must be taken into account when making inter-site comparisons. Trace element data for the Borrobol type-site and for the two original Swedish sites are also published. Results remain inconclusive as no differences were found between the Swedish and Scottish horizons. Even some problems with confusing the Hasseldalen Tephra with another horizon, the Askja-S Tephra, in Swedish sites are considered.
A miniaturized system to secure the cold chain

We have developed an affordable and easy-to-adopt way of securing cold chains: Tempix time-temperature smart labels. Our labels guarantee that products are handled at the correct temperature throughout the entire cold chain. If the product is exposed to conditions above the stipulated temperature for an extended period, the bar code will be blocked rendering it unsellable. We provide a complete turnkey solution comprising a 2- in-1 thermal label printer and a cover label applicator. The market has welcomed our innovation. Nowadays, Tempix labels secure LIDL’s fresh fish cold chains in Finland. Furthermore, we are running pilots with other prestigious companies around the world. For all its virtues we are aware of the limitations of our solution. Tempix printers are big and require compressed air to operate. These factors restrict our targeted users to major primary food producers and factories with large single story floor space. For Tempix technology to reach its full potential, it is necessary to develop a desktop-sized version of our system. To scale up, we must scale down. In this Phase 1 study, we will scout for the most suitable technology and manufacturing partner to achieve miniaturisation. Simultaneously, we will develop a strategy for market deployment.
Abnormal distribution of microhardness in tungsten inert gas arc butt-welded AZ61 magnesium alloy plates

In this study, the effects of heat input on the distribution of microhardness of tungsten inert gas (TIG) arc welded hot-extruded AZ61 magnesium alloy joints were investigated. The results show that with an increase of heat input, the distributions of microhardness at the top and bottom of the welded joints are different because they are determined by both the effect of grain coarsening and the effect of dispersion strengthening. With an increase of the heat input, the microhardness of the heat-affected zone (HAZ) at the top and bottom of welded joints and the fusion zone (FZ) at the bottom of welded joints decreased gradually, while the microhardness of the FZ at the top of welded joints decreased initially and then increased sharply. The reason for the abnormal distribution of microhardness of the FZ at the top of the welded joints is that this area is close to the heat source during welding and then large numbers of hard {beta}-Mg{sub 17}(Al,Zn){sub 12} particles are precipitated. Hence, in this case, the effect of dispersion strengthening dominated the microhardness.
GENERATING CONFORMAL STRUCTURES FOR 3D OBJECT MODELS

In an example implementation, a method of generating a conformal structure, includes generating a bottom surface and a top surface of a conformal structure, positioning seed points on a seed surface, where the seed surface comprises the bottom surface or the top surface, and expanding the seed points as spherical cells whose cell boundaries form walls perpendicular to the surfaces as the cell boundaries intersect with cell boundaries of neighboring spherical cells. The method includes intersecting the walls with the top surface as the cells expand vertically upward from the seed surface and intersecting the walls with the bottom surface as the cells expand vertically downward from the seed surface, and applying the conformal structure to a 3D object model for fabrication in an additive manufacturing device.
Hydrophobicity is a hallmark of immunogenic MHC class I T cell epitopes (APP2P.111)

The molecular mechanisms underlying MHC class I-peptide immunogenicity are not well defined. Here, we investigated the biochemical properties that are associated with immunogenicity from immunogenic (n=5035) and non-immunogenic (n=4853) MHC-I peptides curated from the Immune Epitope Database (IEDB). Using a bioinformatic comparative analysis, we evaluated three amino acid properties (hydrophobicity, side chain mass, and polarity) for an association with immunogenicity within the pMHC dataset. We found a strong bias towards hydrophobic amino acid usage within immunogenic peptides (Spearman ρ = 0.71, P = 4.24 x 10^-4); this difference in hydrophobicity is due to preferential usage of non-polar hydrophobic amino acids in TCR-contact residues for peptides restricted by HLA-A2, H-2Db, H-2Kb (P-values < 0.01). We used amino acid hydrophobicity to design an artificial neural network (ANN) model of immunogenicity for MHC-I peptides. We trained this model to predict mouse H2Db-restricted immunogenic epitopes for 4 different antigens from LCMV, Adenovirus, and Influenza A virus. Our findings suggest that hydrophobicity of TCR contact residues may be a fundamental biochemical hallmark that favors immunogenicity of MHC/peptide complexes. Incorporating hydrophobicity into epitope prediction algorithms may improve prediction of immunogenic CTL epitopes.
Automated model inference from neural dynamics for a mechanistic understanding of cognition

Human cognition depends on complex coordinated dynamics of neural populations, which is shaped by a rich heterogeneity in cellular properties and network connectivity patterns of neural circuits. While cognitive neuroscience leverages macroscopic brain signals to relate neural activity to behavioral states, we currently cannot dissect them for their physiological contributions, hindering mechanistic interpretations of experimental data. One way to systematically study how physiological parameters shape neural dynamics is through mechanistic modeling of spiking neural networks. However, current modeling approaches are not quantitatively constrained by observed electrophysiological data, and often require painstaking and ad-hoc parameter-tuning by hand. Efficient discovery of mechanistic models that are consistent with experimental data would dramatically accelerate our understanding of how cellular and network properties impact cognition, and why it breaks down in pathological states, representing a radical departure from how neural data is analyzed in cognitive neuroscience. To this end, I propose to develop a machine learning-assisted model inference tool—Automated Model Inference from Neural Dynamics (AutoMIND)—that can identify parameters of candidate spiking neural network models that could capture arbitrary target neural dynamics from human brain recordings. AutoMIND extends on recent advances in simulation-based inference techniques, incorporating simultaneous parameter manifold-learning and gradient-based simulations. AutoMIND has broad utility for tackling neuroscientific questions by enabling expedited in-silico experiments. Here, I apply it to multiscale neural data to study how cellular and network properties shape: 1) the emergence of synchronous network oscillations during early neurodevelopment, and 2) the difference in neural dynamics and computation between sensory and association cortices—two questions of fundamental importance to neuroscience.
SCHWIMMBECKEN AUS METALL ODER KUNSTSTOFF

Die vorliegende Erfindung betrifft ein Schwimmbecken aus Kunststoff oder aus Metall, insbesondere aus Edelstahl, welches aus einem Bodenteil und senkrechten Seitenteilen zusammengesetzt ist und über herkömmliche Einrichtungen für den Wasserzulauf und den Wasserablauf, sowie gegebenenfalls auch über Beleuchtungseinrichtungen, Massagedüsen, Düsen einer Gegenstromanlage und dergleichen mehr verfügt, welches sich durch waagrecht verlaufende Versteifungen auszeichnet, die von Vertiefungen 3 gebildet werden, die von Blenden 5 abgedeckt sind.
Asymptomatic postmenopausal women with sonographically thickened endometrium. What do we do?

Background: A thickened endometrium in the postmenopausal
patient is a common reason for referral to gynaecology rapid access clinics
under the cancer targets wait. This can often be an incidental finding in the
asymptomatic patient. Investigation of this can be invasive, uncomfortable and
carries significant surgical risk. Aims: This paper aims to summarise all the
recent literature to see if there is any clear consensus on who should be
further investigated in this select group of patients. Methods: Systematic
literature review. Results: The studies varied greatly on the need for further
investigation in asymptomatic women with endometrial thickness greater than 11 mm,
with some deciding on careful case selection for further investigation, and
others investigating every patient. The treatment of asymptomatic patients with
endometrium classified as thickened, yet under 11 mm and no symptoms again
varied in case selection and further investigation. Endometrial polyps were mentioned
in 1 paper, suggesting that asymptomatic polyps need not be removed, which is
contrary to current clinical practice. Conclusion: There is no overall opinion
as to the exact treatment of women with thickened endometrium. Women should be
carefully triaged and all other factors taken into account
before further investigation are instigated.
A DEVICE FOR RELEASABLY SECURING ONE UNIT AGAINST A SECOND UNIT

A device (10) is provided for use in releasably securing one unit (e.g., the rear end of a truck vehicle) against a second unit (e.g., a loading dock (D)). The device (10) comprises an elongated member (11) mounted for controlled endwise movement relative to a locking assembly (17), the latter being adjustably mounted on the loading dock (D). Carried by the elongated member (11) and extending from an end thereof towards the truck is an attaching cable (12) which is adapted to be releasably secured to the truck when the elongated member (11) is disposed in a predetermined relative position with respect to the locking assembly (17). A brake (25) is adjustably mounted within the locking assembly (17) for movement between operative and inoperative positions. When the brake (25) is in an operative position, the exterior of the elongated member (11) is frictionally engaged thereby so that the elongated member (11) can be moved endwise in only one direction away from the truck. When the brake (25) is in an inoperative position, the elongated member (11) can be moved in either endwise direction relative to the locking assembly (17). The brake (25) is biased to normally assume an operative position. Manually actuated lever (32) and finger (30) are carried on the locking assembly (17) for moving the brake (25) from an operative position to an inoperative position.
LAUNDRY WASHING MACHINE WITH AN IMPROVED FRONT DOOR MOUNTING MECHANISM

The present invention relates to a laundry washing machine (1) having an outer frame (10) with a front door (4) mounting mechanism. The present invention more particularly relates to a laundry washing machine (1) comprising a cabinet having a front wall (3), an upper door (6) and a main body (2). The laundry washing machine (1) further comprises a front door (4) allowing access into a drum for loading or unloading laundry, the front door (4) being openable by means of a handle (28) mounted to an outer frame (10) of the front door (4).
Interictal EEG denoising using independent component analysis and empirical mode decomposition

Noise contamination is inevitable in biomedical recordings. In some cases biomedical recordings are highly contaminated with artifacts which make the effective recovering process hard to achieve. Many different methods have been proposed for artifact removal from biomedical signals but introducing an effective method which can present valuable data for medical analysis, is still an ongoing process. In this paper a new method for interictal EEG denoising is presented. Single-channel ICA denoising method based on EMD decomposition is used to improve the multi-channel ICA denoising results. This method is tested on simulated epileptic recordings which are contaminated with real muscle artifact and EEG background activity.
Effects of LPS on the accumulation of lipid droplets, proliferation, and steroidogenesis in goat luteinized granulosa cells

Lipopolysaccharide (LPS) can cause ovarian dysfunction and infertility in mammals. The purpose of this study was to investigate the effects of LPS on the accumulation of lipid droplets (LDs), proliferation, and steroidogenesis in goat luteinized granulosa cells (LGCs). GCs isolated from the ovarian follicles were spontaneously luteinized under media with fetal bovine serum, resulting in increased progesterone and shifted shape from spherical to star with multiple prolongations. Then, LGCs were treated with LPS (0-10 μg/mL) for 0-48 hours. Oil Red O staining was performed to observe LDs accumulation and commercial kit was applied to detect intracellular triglyceride (TG) content. The cell proliferation were detected by cell counting kit-8. Expressions of cell-cycle-related genes were determined by real-time polymerase chain reaction. Estradiol (E 2 ) and progesterone (P 4 ) from cell supernatants were determined by enzyme-linked immunosorbent assay, and expressions of STAR, P450scc, 3β-hydroxysteroid dehydrogenase (3β-HSD) and CYP19A1 were detected by Western blot. Results showed that LPS treatment significantly increased LDs accumulation after 24 hours, and 5 μg/mL LPS increased TG content ( P < 0.05). LPS treatment for 24 hours stimulated the LGCs activities ( P<0.05), which was confirmed by the increases in the expressions of proliferating cell nuclear antigen (PCNA), cyclinB1 and cyclinD1, while 48 hours treatment had no effect. LPS treatment suppressed E 2 and P 4 output of LGCs ( P < 0.05). Western blot results showed that 10 μg/mL LPS decreased the protein expression of 3β-HSD in LGCs ( P < 0.05). In conclusion, LPS increased LDs accumulation and cell proliferation, and LPS-mediated P 4 reduction could be attributed to the decreased 3β-HSD protein expression, which provide new information for the regulation of ovarian function in goats.