SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Medical device for automatic preparation of high quality foam for sclerotherapy of varicose veins

Approximately 25% of adults have varicose veins, with prevalence increasing to over 80% if spider veins are also considered. The rising geriatric population is further accelerating these figures, as one in two people over the age of 50 are affected by varicose veins. In recent years, due to the possibility of infection and other adverse effects during invasive surgeries, traditional surgical treatment (surgical ligation and stripping) has given way to minimally invasive procedures, which also reduce hospital stays and costs. Consequently, a growing number of doctors are adopting foam sclerotherapy, endovenous laser treatment, and radiofrequency ablation over conventional surgical practices. Within these new treatment approaches, foam sclerotherapy is the preferred approach given its favourable efficacy and safety profile coupled with simplicity and relatively low cost. Foam sclerotherapy involves transforming a chemical sclerosing agent into foam and injecting it into the affected vein. The sclerosant foam irritates the lining of the blood vessel, causing it to collapse and stick together. Current manual foam preparation method broadly utilized by doctors (Tessari’s method) presents substantial limitations in terms of quality, consistency, versatility, and safety. VARIXIO Sclerotherapy Microfoam System being developed by VB Devices addresses these limitations by automating, standardizing, and greatly simplifying foam preparation. VARIXIO adds versatility and safety to this obsolote treatment method. Having secured patent protection for the device and validated the concept at the prototype level, the company is seeking
funding to pursue industrial, regulatory, and commercial feasibility of the VARIXIO device.
METHODS OF DELIVERY OF EXOGENOUS PROTEINS TO THE CYTOSOL AND USES THEREOF

The present invention is directed to a method for delivering exogenous proteins to the cytosol, by binding a target antigen (such as a protein) to a transport factor that contains a fragment of a bipartite protein exotoxin, but not the corresponding protective antigen. Preferably, the target antigen is fused to the transport factor. Preferred transport factors include the protective antigen binding domain of lethal factor (LFn) from B.anthracis, consisting of amino acids 1-255, preferably a fragment of at least 80 amino acids that shows at least 80 % homology to LFn, and a fragment of about 105 amino acids from the carboxy portion that does not bind PA. The target antigen can include any molecule for which it would be desirable to elicit a CMI response, including viral antigens and tumor antigens.
Biomechanical engineer for robotic healthcare solutions

Neuromuscular diseases (NMD) such as Dystrophies, Atrophies, Paralysis or Neuropathies are a group of more than 150 genetic illnesses affecting the lower neuromotor system, which include the muscles and nerves system. NMDs share the common traits of childhood onset and progressive muscle weakness, which lead to walk disability, loss of autonomy and psychosocial consequences. 
There is currently not treatment available to halt the progressive course of these NMDs. Most therapeutic approaches are limited to medicines (by reducing symptoms) and musculoskeletal rehabilitation in-clinic programs, as neurological disorders main feature is the loss of muscles strength and a progressive lack of walking. The key is maintaining walking ability for slowing the deterioration caused by permanent sitting, giving hope for a better and more independent life. Marsi Bionics offers an innovative approach: Wearable Gait Exoskeletons as and effective 24/7 in-house therapy solution for allowing NMD children to walk.
ATLAS 2020 is the first paediatric exoskeleton we developed for using in hospitals/rehabilitation centres. Our purpose and why we need and expert in biomechanics is to get ready a more advanced version, ATLAS 2030 for expanding rehabilitation to home and activities of daily living, building a paradigm for NMD rehabilitation. To achieve this goal we are working on providing self-balance capabilities to the exoskeleton. The company is looking for a qualified biomechanical engineer with an excellent background in human locomotion for improving ergonomics and biomechanics of gait balance of our bionics exoskeletons and to analyse the gait dysfunctions from NMD pathologies. 
The potential Marsi Bionics would achieve improving ATLAS 2030, by accomplishing the ideal ergonomics aspects related to each NMD mobility pattern during the gait by recruiting an expert in Biomechanics, will reinforce research in robotic area for health and will create new market opportunities.
Internet of Things Based Weather-Soil Sensor Station for Precision Agriculture

This paper presents the design, development, and testing of a customizable and cost-effective Weather-Soil Sensor Station (W-SSS) for use in Precision Agriculture based on high accuracy sensors, wireless communication, cloud data storage, and computation technology. The W-SSSs operated from July 25, 2018, to September 15, 2018, using an off-grid power system, Arduino microcontroller, and Wi-Fi connection to the cloud. Sensor data quality was evaluated using several statistical techniques. The data obtained from the weather-soil stations illustrate the differences in weather and soil conditions both relative to the local weather station as well as those within a field. Knowledge of these differences would allow a farmer to vary planting densities relative to soil conditions, irrigation control, as well as pest/herbicide management.
Redefining the agency: post-1989 crises of czech and former east german theatre

""Redefining the Agency: Post-1989 Crises of Czech and Former East German Theatre"" will introduce an innovative historiographical and theoretical approach to examining the inter-relation between theatre and the society. The process of the redefinition of theatre’s function during transformations of social and political discourses will be investigated within a case study which will give the first comparison of Czech and the former East German theatre after 1989. The research will focus on the period of genuine societal transformation between 1990 and 1995 and will proceed along the intersection of theatre studies, media studies, and political history. Within the interdisciplinary research, the notion of agency will be brought into discussion to explore its potential for theatre studies. Therefore, ""Redefining the Agency"" will apply an innovative methodology combining discourse analysis with performance analysis. The 2-year-project will result in a monograph written in English, which will introduce the theoretical framework and method, as well as the findings of the research to the broadest international audiences.
THE <i>CHANDRA</i> M101 MEGASECOND: DIFFUSE EMISSION

Because MIOl is nearly face-on, it provides an excellent laboratory in which to study the distribution of X-ray emitting gas in a typical late-type spiral galaxy. We obtained a Chandra observation with a cumulative exposure of roughly 1 Ms to study the diffuse X-ray emission in MlOl. The bulk of the X-ray emission is correlated with the star formation traced by the FUV emission. The global FUV/Xray correlation is non-linear (the X-ray surface brightness is roughly proportional to the square root of the FUV surface brightness) and the small-scale correlation is poor, probably due to the delay between the FUV emission and the X-ray production ill star-forming regions. The X-ray emission contains only minor contributions from unresolved stars (approximates less than 3%), unresolved X-ray point sources (approximates less than 4%), and individual supernova remnants (approximates 3%). The global spectrum of the diffuse emission can be reasonably well fitted with a three component thermal model, but the fitted temperatures are not unique; many distributions of emission measure can produce the same temperatures when observed with the current CCD energy resolution. The spectrum of the diffuse emission depends on the environment; regions with higher X-ray surface brightnesses have relatively stronger hard components, but there is no significant evidence that the temperatures of the emitting components increase with surface brightness.
Finite Element Analysis of the State of Stresses on the Structures of Buildings Influenced by Underground Mining of Hard Coal Seams in the Jiu Valley Basin (Romania)

The hard coal seams in the Jiu Valley mining basin have been mined with different mining methods and technologies, including with the complete caving of the surrounding rocks and with top coal caving. These mining systems have led to the degradation of the ground surface by producing subsidence of the land, ranging from a few meters up to tens of meters, in the areas with thick coal seams with high dips. When the limits of the main safety pillars are accidentally exceeded whilst mining, buildings situated either below the ground or on the surface are affected. In the future, the possibility exists of mining some of the very large reserves that are immobilized in the main safety pillars, where the gentle dip seams are stored. In consideration of the above, in order to study the behaviour of typical buildings that are under the influence of underground mining and to develop a model of the stress state in the structural elements of the structures, finite element modelling is used. As such, several modelled buildings with one, two, and three levels were generated, as well as buildings with two levels and with different lengths. These buildings were built of reinforced concrete panels or brick masonry and were subjected to the mining influence of a panel specific to the mines in the Jiu Valley basin, sequentially extracted with a longwall coal face method at different operating heights, with the use of roof control by caving of rocks and with top coal caving methods. Following the analysis of the major principal (tensile) stresses and minor principal (compressive) stresses, a series of conclusions regarding the behaviour of these buildings that are under the influence of the underground mining is revealed. In this context, it was concluded that the value and location of the stresses developed in the structure of the buildings depend mainly on the extension of the panel and the volume of the goaf, the relative position of the building in respect to the coal face line, and the length of the building.
Onyx embolization of carotid-cavernous fistulas

Object The authors conducted a study to determine the safety and efficacy of embolization of carotid-cavernous fistulas (CCFs) with the ethylene vinyl alcohol copolymer, Onyx. Methods They prospectively collected data in all patients with CCFs who underwent Onyx-based embolization at their institution over a 3-year period. The type of fistula, route of embolization, viscosity of Onyx, additional use of coils, extent of embolization, procedural complications, and clinical follow-up were recorded. Results A total of 12 patients (5 men and 7 women who were age 24–88 years) underwent embolization in which Onyx was used. There were 1 Barrow Type A, 1 Type B, 3 Type C, and 7 Type D fistulas. Embolization was performed via a transvenous route in 8 cases and a transarterial route in 4 cases. Onyx 34 was used in all but 2 cases: a direct Type A fistula embolized with Onyx 500 and an indirect Type C fistula embolized with Onyx 18. Adjuvant embolization with framing coils was performed in 7 cases. All procedures were completed in a single session. Immediate fistula obliteration was achieved in all cases. Clinical resolution of presenting symptoms occurred in 100% of the patients by 2 months. Neurological complications occurred in 3 patients. One patient developed a complete cranial nerve (CN) VII palsy that has not resolved. Two patients developed transient neuropathies—1 a Horner syndrome and partial CN VI palsy, and 1 a complete CN III and partial CN V palsy. Radiographic follow-up (mean 16 months, range 4–35 months) was available in 6 patients with complete resolution of the lesion in all. Conclusions Onyx is a liquid embolic agent that is effective in the treatment of CCFs but not without hazards. Postembolization cavernous sinus thrombosis and swelling may result in transient compressive cranial neuropathies. The inherent gradual polymerization properties of Onyx allow for casting of the cavernous sinus but may potentially result in deep penetration within arterial collaterals that can cause CN ischemia/infarction. Although not proven, the angiotoxic effects of dimethyl sulfoxide may also play a role in postembolization CN deficits.
Warming and nitrogen deposition lessen microbial residue contribution to soil carbon pool

Microorganisms have a role as gatekeepers for terrestrial carbon fluxes, either causing its release to the atmosphere through their decomposition activities or preventing its release by stabilizing the carbon in a form that cannot be easily decomposed. Although research has focused on microbial sources of greenhouse gas production, somewhat limited attention has been paid to the microbial role in carbon sequestration. However, increasing numbers of reports indicate the importance of incorporating microbial-derived carbon into soil stable carbon pools. Here we investigate microbial residues in a California annual grassland after a continuous 9-year manipulation of three environmental factors (elevated CO(2), warming and nitrogen deposition), singly and in combination. Our results indicate that warming and nitrogen deposition can both alter the fraction of carbon derived from microbes in soils, though for two very different reasons. A reduction in microbial carbon contribution to stable carbon pools may have implications for our predictions of global change impacts on soil stored carbon.
Network-side positioning of cellular-band devices with minimal effort

We address the problem of network-side localization where cellular operators are interested in localizing cellular devices by means of signal strength measurements alone. While fingerprinting-based approaches have been used recently to address this problem, they require significant amount of geo-tagged (‘labeled’) measurement data that is expensive for the operator to collect. Our goal is to use semi-supervised and unsupervised machine learning techniques to reduce or eliminate this effort without compromising the accuracy of localization. Our experimental results in a university campus (6 sq. km) demonstrate that sub-100m median localization accuracy is achievable with very little or no labeled data so long as enough training is possible with ‘unlabeled’ measurements. This provides an opportunity for the operator to improve the model with time. We present extensive analysis of the error characteristics to gain insight and improve performance, including understanding spatial properties and developing confidence measures.
Long-term trends in restoration and associated land treatments in the southwestern United States

Restoration treatments, such as revegetation with seeding or invasive species removal, have been applied on U.S. public lands for decades. Temporal trends in these management actions have not been extensively summarized previously, particularly in the southwestern United States where invasive plant species, drought, and fire have altered dryland ecosystems. We assessed long-term (1940–2010) trends in restoration using approximately 4,000 vegetation treatments conducted on Bureau of Land Management lands across the southwestern United States. We found that since 1940, the proportions of seeding and vegetation/soil manipulation (e.g. vegetation removal or plowing) treatments have declined, while the proportions of prescribed burn and invasive species treatments have increased. Treatments in pinyon-juniper and big sagebrush communities declined in comparison to treatments in desert scrub, creosote bush, and riparian woodland communities. Restoration-focused treatment objectives increased relative to resource extraction objectives. Species richness and proportion of native species used in seeding treatments also increased. Inflation-adjusted costs per area rose 750% for vegetation/soil manipulation, 600% for seeding, and 400% for prescribed burn treatments in the decades from 1981 to 2010. Seeding treatments were implemented in warmer and drier years when compared to the climate conditions of the entire study period and warmer and wetter years relative to several years before and after the treatment. These results suggest that treatments over a 70-year period on public lands in the southwestern United States are shifting toward restoration practices that are increasingly large, expensive, and related to fire and invasive species control.
Improving Scratch Programming with CRC-Card Design

Scratch and other block-based programming environments are popular and successful in engaging young learners with basic concepts of programming. It is common, and intentional, that programming with Scratch is done using an explorative tinkering approach, where blocks are selected from toolboxes and assembled. However, this type of bottom-up programming behaviour is generally associated with code quality issues, makes it difficult to create more complex programs, and may impede the learning of fundamental concepts. In order to investigate whether a more structured approach is feasible, we adapted the object-oriented design methodology of CRC cards (class-responsibility-collaboration) to Scratch programs, such that learners first plan the central aspects of their programs (i.e., the sprites and their interactions), before writing the code. We applied this methodology in the context of a pilot study with two school classes to investigate how this affects the students and their resulting projects. The results of this initial investigation suggest that students are not deterred by the additional design work, and we observed a slight improvement in the completeness and correctness of the resulting programs.
Molecular uptake mechanisms controlling plant growth

Life on Earth is sustained by plants. Growth and development in the plant kingdom is mediated by the controlled distribution of sugars and the hormone auxin, but we still know surprisingly little about the molecular details of this essential part of fundamental plant metabolism. MUM-GROW will elucidate the molecular mechanism of sugar and auxin transmembrane transport in plants. It moves the frontiers of the field by shifting the focus to molecular studies in vitro allowing structural and biochemical experiments to be performed.

Correct plant growth and development is completely dependent on sugar uptake in growth zones (the meristem), and made possible in all plants by sugar transporters called SUCs and STPs. Growth polarity is created by an asymmetrical gradient of auxin mediated by auxin transporters called PINs. Despite extensive research, the molecular mechanisms of SUC, STP and PIN transport remains unknown. If we knew the molecular determinants of their function, it would allow us to predict, augment and possibly modify plant responses to a changing environment.

I will address this using a complementary set of methods founded in structural biology to determine the 3-dimensional structures of key players in these transmembrane transport systems. This will be combined with biochemical characterization to address important mechanistic questions and elucidate their molecular mechanism.

Understanding the mechanisms that govern plasticity in growth is essential for determining resilience of whole ecosystems. This proposal will lead to a breakthrough in our understanding of sugar and auxin homeostasis, a fundamental part of basic plant metabolism. It has tremendous potential for the societal challenge to secure sufficient food for our global population in a sustainable balance between environmental impact and resource exploitation. Furthermore, this proposal will uncover general molecular principles of transmembrane uptake and export pertaining to all organisms.
Tax and transfer policies and the female labor supply in the EU

This study measures the effect of tax–benefit policies on female labor supply based on a broad sample of 26 European countries in 2005–2010. The tax–benefit microsimulation model EUROMOD is used to calculate a measure of work incentives at the extensive margin—the participation tax rate, which is then used as the main explanatory variable in a female employment equation. This allows me to deal with the endogeneity of income in a new way by using a simulated instrumental variable based on a fixed EU-wide sample of women. The results suggest that a 10 percentage point increase in the participation tax rate decreases the female employment probability by 2.5 percentage points. The effect is higher for single mothers, for women in the middle of the skills distribution, and in countries that have lower rates of female employment.
Propuestas para la dinamización turística y ordenación de los usos recreativos en el Parque Natural de las Lagunas de la Mata-Torrevieja (Alicante)

espanolEn esta comunicacion se propone una metodologia para la planificacion turistica de los espacios naturales que contemple propuestas para incrementar el uso turistico del espacio, basadas en la estructuracion de productos turisticos novedosos, en consonancia con la zonificacion de usos y actividades que establecen los instrumentos de planificacion ambiental. Aunque se toma como referencia la investigation realizada sobre un espacio natural concreto (el Parque Natural de las Lagunas de la Mata-Torrevieja), el objetivo perseguido es ofrecer una metodologia de trabajo util para la dinamizacion turistica de otros espacios naturales de la Comunitat Valenciana. En el estudio realizado para la dinamizacion turistica del espacio, las propuestas se articulan en relacion con los valores naturales y culturales propios del espacio natural y tomando como herramienta clave de gestion la interpretacion del patrimonio. EnglishIn the present paper, it is highlighted a methodology for the tourism planning of natural areas with the aim to increase the tourist activity in the area through the creation of new tourist products but having into consideration the environment preservation according to the policy and tools of the protected natural areas. Taking into consideration the research of a particular natural area (La Mata-Torrevieja Nature Reserve), the aim is to create a methodology that could he applied for the tourist revitalization of other natural areas of the Valencian Community. In the research, the main proposals are based on the natural and cultural values of the natural area with the heritage interpretation as the key tool to be considered for its management.
Reliable SPICE Simulations of Memristors, Memcapacitors and Meminductors

Memory circuit elements, namely memristive, memcapacitive and meminductive systems, are gaining con- siderable attention due to their ubiquity and use in diverse areas of science and technology. Their modeling within the most widely used environment, SPICE, is thus critical to make substantial progress in the design and analysis of com- plex circuits. Here, we present a collection of models of different memory circuit elements and provide a methodol- ogy for their accurate and reliable modeling in the SPICE environment. We also provide codes of these models writ- ten in the most popular SPICE versions (PSpice, LTspice, HSPICE) for the benefit of the reader. We expect this to be of great value to the growing community of scientists inter- ested in the wide range of applications of memory circuit elements.