SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Professional cross-priming for ovary and prostate cancer

Immune responses are initiated by antigen presentation mediated by dendritic cells (DC). There is a minority subset of DC highly specialised in starting up cytotoxic T lymphocytes able to kill tumor cells. PROCROP aims to develop in three pilot clinical trials a suitable individualized cancer vaccine technology for castration resistant prostate cancer and metastatic cancer of the ovary that would complement currently available therapies to increase efficacy. The project applies recent compelling knowledge on the identity of the main antigen-presenting DC subsets for vaccine elicitation of cytotoxic T lymphocytes endowed with the ability to seek and destroy tumour cells (such immune mechanism is termed crosspriming). This unique opportunity for superior DCs for immunotherapy comes from the fact that Miltenyi, a successful European biotech company, has the necessary proprietary reagents (anti-BDCA-3 monoclonal antibody and immunomagnetic selection technology), as well as the expertise to clinically develop a strategy of DC isolation and short-term cell culture for immunotherapy. From the point of view of the tumor antigens, processed autologous tumor material will be mixed with defined common tumor antigens in the form of recombinant proteins. This novel combination will permit stronger and broader antitumor immune responses and more accurate monitoring of the ensuing immunity against the tumors. These features should make the novel DC vaccine more efficacious than the currently US-approved DC vaccine PROVENGE and other DCs preparations undergoing trials, such as those derived from monocytes. Three of the leading groups in immunotherapy of cancer in Europe would join forces to develop this individualized cell therapy technology in clinical trials for two highly prevalent and unsatisfactorily managed malignant conditions. Industrial partnership provides the unique advantage of producing a rigorously standardized product for eventual multicentre trials.
La Catalogna in Dante (dal Fiore alla Monarchia)

Riassunto: L&rsquo;articolo analizza e mette in rapporto quattro passaggi danteschi nei quali viene nominata (oppure evocata) la Catalogna: dal Fiore, dalla Commedia, dal De Vulgari Eloquentia e dalla Monarchia, nei quali emerge, da una parte, una idea organica (anche se soggettiva), del luogo che occupa la Catalogna nello spazio linguistico e politico europeo, e dall&rsquo;altra la coerenza di tali approcci. Parole chiave: gelosia, avarizia, giustizia, lingua, impero Abstract: The article analyses and relates four Dante passages in which Catalonia is named (or evoked): from the Fiore, from the Commedia, from the De Vulgari Eloquentia and from the Monarchia, in which emerges, on the one hand, an organic idea (even if subjective), of the place that Catalonia occupies in the European linguistic and political space, and on the other the coherence of these approaches Keywords: jealousy, avarice, justice, language, empire&nbsp
CONSTRUCTS AND METHODS FOR EFFICIENT TRANSFORMATION OF MICRO-ORGANISMS FOR PRODUCTION OF CARBON-BASED PRODUCTS OF INTEREST

Improved constructs for increasing efficiency of transformation of thermophilic host cells for production of carbon-based products of interest and methods for producing carbon- based products of interest are provided.
Optimization of medical accelerators

Cancer is a major social problem, and it is the main cause of death between the ages 45-65 years. In the treatment of cancer, radio therapy (RT) plays an essential role. RT with hadrons (protons and light ions), due to their unique physical and radiobiological properties, offers several advantages over photons for specific cancer types. In particular, they penetrate the patient with minimal diffusion, they deposit maximum energy at the end of their range, and they can be shaped as narrow focused and scanned pencil beams of variable penetration depth. Although significant progress has been made in the use of particle beams for cancer treatment, an extensive research and development program is still needed to maximize the healthcare benefits from these therapies. 
The Optimization of Medical Accelerators (OMA) is the aim of the here-proposed European Training Network, in line with the requirements of the EC’s Medical Exposure Directive. OMA joins universities, research centers and clinical facilities with industry partners to address the challenges in treatment facility design and optimization, numerical simulations for the development of advanced treatment schemes, and in beam imaging and treatment monitoring.
The proposed R&D program ranges from life sciences (oncology, cell and micro biology and medical imaging.), physics and accelerator sciences, mathematics and IT, to engineering. It is hence ideally suited for an innovative training of early stage researchers. By closely linking all above research areas, OMA will provide an interdisciplinary education to its Fellows. This will equip them with solid knowledge also in research areas adjacent to their core research field, as well as with business competences and hence give them a perfect basis for a career in research.
Sens solutions smart disinfection platform for legionella prevention in hospital and hotel water heating & cooling systems.

Legionella is responsible for around 2000 deaths in Europe every year, resulting in a direct cost of 1B€/year for EU healthcare systems including working days lost and those numbers increase by 9% every year. In 2015, 7034 Legionella outbreaks have been occurring in the whole Europe with a fatality rate reaching up 50% in the hospital-acquired infections and 50% of the outbreak cases associated with holidays associated facilities. Up to now, the Legionella detection is performed through in situ sampling and analysis in Microbiology Laboratories, delaying the results and any possible actuation by 13 days. Hydro-S3DP is a global secured IoT solution, combining virtual & physical sensors with Big Data Machine learning process and state-of-the-art disinfection systems that allows in-situ detection of Legionella proliferation and direct disinfection for bacterial treatment in water cooling & heating systems in less than 2h. Moreover, Hydro-S3DP acts directly on the lime deposition reduction within the cooling & heating system, allowing an energy bill saving up to 70 000€/year in hard water environment per building facility and an increase of the system life span from 5-8 to 25 years. All together, the EU market for hospital and hotel is estimated to be ~3.4B€/year. Upon commercialization of Hydro-S3DP in Spain and progressively in the rest of Europe sales are projected to reach 5.5M€ and to employ 12 people by 2022 (1.5 year after the end of the Phase II). More than an economical solution for cooling & heating systems, Hydro-S3DP responds to a challenge of the European Centre for Disease Prevention and Control by preventing any Legionella outbreaks as well as offering a solution for hospital and hotel to improve their energy efficiency in accordance with the COM(2016)860 Directive from the Energy Union, and ensure their water security.
Comparison of Sr-doped and Sr-free La1−xSrxMn0.5Cr0.5O3±δ SOFC Anodes

Abstract Single phase La 1  −  x S r x Mn 0.5 Cr 0.5 O 3 ±  δ (LSMC, x Sr  = 0 and 0.2) and composite LSMC:Gd-doped ceria (GDC) mixed ionic and electronic conducting anodes were studied in half-cell and full-cell electrochemical configurations using humidified fuel environments at 700 to 800 °C. We demonstrate here that the removal of Sr from La 1  −  x S r x Mn 0.5 Cr 0.5 O 3 ±  δ improves both the thermo-chemical stability and the electronic conductivity of these materials in a humidified H 2 environment, while also enhancing their H 2 oxidation activity, when operating at 700 and 800 °C. It is also shown that the addition of 50:50 wt.% GDC:LaMn 0.5 Cr 0.5 O 3 ±  δ results in the retention of all of these benefits, as compared to a mixture of GDC with the Sr-containing La 0.8 Sr 0.2 Mn 0.5 Cr 0.5 O 3 ±  δ ( x Sr  = 0.2) oxide.
Model-based fault detection, isolation and fault-tolerant control for a class of nonlinear uncertain systems using information estimation

In this paper, we propose a fault detection, isolation and fault-tolerant control scheme for a class of nonlinear uncertain systems with possible state and sensor failures. First, a model-based nonlinear estimator using input-output information is designed by considering both state and sensor failures. This estimator is used to generate the residual signal which is for detecting both state and sensor failures. Second, multiple fault estimators are proposed to design fault isolation scheme for finding the fault type or location. Third, utilizing fault estimated, a fault tolerant control algorithm is designed to maintain the system operation continuously after a fault is detected. Finally, simulation is given to demonstrate how the proposed scheme can detect a fault occurrence, isolate the fault and engage the fault-tolerant control for the one degree of freedom robot.
Multimodal optical interrogation of neural activity and neuromodulation during sequence processing

The world often presents us with sequences of multisensory stimuli unfolding over time, like a car appearing after we hear it approaching. In the cerebral cortex, individual neurons integrate information across senses and time in order to identify these objects. Meanwhile, neuromodulatory molecules shape neural computations, adapting them to context and experience. It is from this interplay that the spatio-temporal patterns of neural activity containing the code for how we perceive the world originate. However, these activity patterns have long been experimentally inaccessible, and they have never been investigated concurrently to neuromodulation. With this project, I will reveal the causal role of functionally-identified ensembles of neurons in the perception and learning of audio-tactile sequences. I will combine, for the first time, two-photon (2p) imaging and holographic-optogenetics with fluorescent neuromodulation sensors. My experiments will be performed in the posterior parietal cortex (PPC) of the mouse, a multimodal area acting as sensory history buffer. I will focus on noradrenaline (NA), a modulator so far involved in sharpening processing of weak unisensory features. I will 1) test which PPC neurons are sufficient, when activated, to bias perception of multisensory sequences during a behavioural task; 2) simultaneously, I will test whether and how PPC levels of NA change when altering sequence discriminability. My experiments will be supported by a solid theoretical framework based on Information Theory. In conclusion, I will use a unique combination of advanced molecular, optical, and computational tools to pursue a novel, causal and integrative approach to cortical function: one where functional neuronal subgroups and neuromodulation are investigated together, at high-resolution, to explain the multi-layered biological basis of the fascinating interaction between our brains and the world.
Context congruency and robotic facial expressions: Do effects on human perceptions vary across culture?

We performed an experimental study (n=48) of the effects of context congruency on human perceptions of robotic facial expressions across cultures (Western and East Asian individuals). We found that context congruency had a significant effect on human perceptions, and that this effect varied by the emotional valence of the context and facial expression. Moreover, these effects occurred regardless of the cultural background of the participants. In short, there were predictable patterns in the effects of congruent/incongruent environmental context on perceptions of robot affect across Western and East Asian individuals. We argue that these findings fit with a dynamical systems view of social cognition as an emergent phenomenon. Taking advantage of such context effects may ease the constraints for developing culturally-specific affective cues in human-robot interaction, opening the possibility to create culture-neutral models of robots and affective interaction.
Integrated System for Software Application Development

Methods and systems are disclosed for developing a software application through requirements specification, design, effort estimation, assigning and tracking work items, development, testing, collaboration and project management. The system is structured as an integrated software development system allowing for structured, systematic and user friendly set up of requirements specification (including workflow, user interface, business rules and integrations), technical design for UI features and integrations using design patterns, automated effort estimation, automated story card and task creation. The system also provides a novel, audio-video playback capability for workflow visualization. Further, the system provides visual depiction of defects and changed items side-by-side with requirements, as well as predictive modeling of defects that allows for forecasting of defect completion rate. In the preferred embodiment, the system is delivered as a multi-tenant Software as a Service.
Unterstützung bei der Wartung der Aktivitäten des Ferienhausteams Szklarska Poręba im Besitz von Relax-tour Sp.z o.o.

Die Probleme des Unternehmens mit dem Ausbruch der Pandemie: Aufgrund der Schließung aller Hoteleinrichtungen wurden 15 Mitarbeiter in wirtschaftliche Ausfallzeiten zurückgeschickt, 13 Mitarbeiter wurden ihre Stellen reduziert und zurückgeschickt, um Aufgaben zu erfüllen, die nicht mit den operativen Tätigkeiten der Einrichtungen zusammenhängen. Im April 2020 sank die Zahl der Kunden auf null und damit fast 100 % des Umsatzes des gesamten Unternehmens, was die rechtzeitige Rückzahlung von Verbindlichkeiten im Zusammenhang mit dem Betrieb des gesamten Unternehmens und die Zahlung von Fixkosten im Zusammenhang mit der Instandhaltung der Anlagen verhinderte. Die Notwendigkeit, das Projekt umzusetzen: Trotz der Wiederaufnahme der Anlagen sieht sich das Unternehmen aufgrund des deutlich geringeren Interesses an den Hoteldienstleistungen potenzieller Kunden weiterhin mit einem geringeren Umsatz gegenüber dem Vorjahr konfrontiert. Aus Angst vor einer Infektion wurde der touristische Verkehr in den Städten, in denen sich die Einrichtungen befinden, erheblich reduziert. Die Beihilfe wird zur Zahlung der Gehälter und der sozialen Sicherheit in den kommenden Monaten und zur Deckung der laufenden Kosten im Zusammenhang mit dem Betrieb der Einrichtungen sowie zur Zahlung von Verbindlichkeiten verwendet, die aufgrund des Ausbruchs der Pandemie aufgeschoben werden. Trotz geringerer Auslastung in allen Einrichtungen bleiben Fixkosten und Personalwartungskosten auf dem gleichen Niveau, während die Kosten für den Kauf von Chemikalien und den direkten Schutz der Arbeitnehmer aufgrund der Einschränkungen bei der Desinfektion von Räumlichkeiten und Geräten gestiegen sind. Die Beihilfe deckt auch die mit dem Erwerb dieser Mittel verbundenen Kosten. Da die infolge des Ausbruchs der Pandemie verlorenen Einnahmen langfristige Auswirkungen auf die Fähigkeit des Unternehmens haben, seine laufenden Kosten zu decken, sind Beihilfen erforderlich, um die angemeldete Beschäftigung aufrechtzuerhalten.
3D kinematics of mobile-bearing total knee arthroplasty using X-ray fluoroscopy

Total knee arthroplasty (TKA) 3D kinematic analysis requires 2D/3D image registration of X-ray fluoroscopic images and a computer-aided design (CAD) model of the knee implant. However, these techniques cannot provide information on the radiolucent polyethylene insert, since the insert silhouette does not appear clearly in X-ray images. Therefore, it is difficult to obtain the 3D kinematics of the polyethylene insert, particularly the mobile-bearing insert. A technique for 3D kinematic analysis of a mobile-bearing insert used in TKA was developed using X-ray fluoroscopy. The method was tested and a clinical application was evaluated.Tantalum beads and a CAD model of the mobile-bearing TKA insert are used for 3D pose estimation of the mobile-bearing insert used in TKA using X-ray fluoroscopy. The insert model was created using four identical tantalum beads precisely located at known positions in a polyethylene insert using a specially designed insertion device. Finally, the 3D pose of the insert model was estimated using a feature-based 2D/3D registration technique, using the silhouette of beads in fluoroscopic images and the corresponding CAD insert model. In vitro testing for the repeatability of the positioning of the tantalum beads and computer simulations for 3D pose estimation of the mobile-bearing insert were performed.The pose estimation accuracy achieved was sufficient for analyzing mobile-bearing TKA kinematics (RMS error: within 1.0 mm and 1.0°, except for medial-lateral translation). In a clinical application, nine patients with mobile-bearing TKA were investigated and analyzed with respect to a deep knee bending motion.A 3D kinematic analysis technique was developed that enables accurate quantitative evaluation of mobile-bearing TKA kinematics. This method may be useful for improving implant design and optimizing TKA surgical techniques.
Bioferludan: cost-effective humic fertilizers trough digestate treatment at industrial biogas plant

Ludan Renewable Energy S.L. (LRE) is an engineering company with extensive experience in the business of biogas and treatment of bio-wastes. LRE main product is biogas compact plant, focus to small/medium energy projects (250-400 kW) where self-supply and waste management are the main targets. With BIOFERLUDAN project, LRE wants to take a step beyond responding new demands of cost-effective and reliable treatment for the digestate, the main by-product of these installations, developing an on-site recovery process to treat it obtaining high quality humic fertilizers.
BIOFERLUDAN aims to implement in biogas plants a new process to obtain liquid fertilizers with high organic matter content, in form of humic substances, recovering them from the digestate. Based on previous R&D works done by LRE, a biogas plant which use BIOFERLUDAN process will produce a minimum of 60L of fertilizer per ton of digestate. The implementation of the new solution will mean around 450.000 €/year of potential incomes for each plant.
Being a great business opportunity for LRE, the success of this approach relays on the fact that it will constitute a business and improvement opportunity for clients (biogas plants) as well as they will obtain outcomes such as:
─ Improved efficiency and productivity of the biogas plant recovering up to 55% and 25% of thermal and electrical energy surplus respectively produced
─ Diminution of operating cost reducing up to 50% volume of digestate managed (current digestate management cost reaches average annual expenditure of EUR 90,000 for each biogas plant)
─ Increased revenues by commercialisation of high quality fertilizers (450.000 €/year)
─ An estimated return period of the investment of 1,5 years
BIOFERLUDAN success will come from the fact that THERE IS NOT any so competitive solution in the market and, what else, it will suppose an estimated annual turnover of 315 million € considering its implementation in at least 10% of the current 7000 EU biogas plants
Kajian gelatin kulit ikan tuna (Thunnus albacares) yang diproses menggunakan asam asetat

Agustin AT, Sompie M. 2015. Study of tuna fish skin gelatin (Thunnus albacares) were processed using acetic acid. Pros Sem Nas Masy Biodiv Indon 1: 1186-1189. Industrial waste of tuna (Thunnus albacares) has not been used optimally into a product that has high value and utility in the industry. Whereas waste such as bark that composed of hydrolyzed collagen will produce gelatin. Gelatin is a denaturalized protein that is derived from collagen and an important functional biopolymer, which has a very broad application in many industrial fields. This research aimed to study the influence of acetic acid on the characteristics of tuna fish skin gelatin. This study used Completely Randomized Design (CRD) with different concentration of acetic acid solution namely 3%, 6%, and 9%. Each treatment was replicated four times. The analyzed variables were yield, pH values and organoleptic assessment of gelatin. Results from analysis of variance showed that the use of acetic acid solution has a different significant effect (P <0.05) to the yield and the pH value of tuna fish skin gelatin. Results of the organoleptic assessment indicate that the difference in the concentration of acetic acid gives the same effect on the color, texture, and smell of gelatin. Gelatin is a bright color to yellowish, slightly irregular rough texture and odorless. In comparison with commercial gelatin product, it appeared that gelatin from the skin of tuna fish had almost occupied the same color with commercial gelatin. It can be concluded that the characteristics of gelatin from the skin of tuna fish using various concentration of acetic acid solution such as 3%, 6%, and 9% are good quality and in accordance with the Indonesian National Standard.
Estimation of the benefits for shippers from a multimodal transport network

This paper develops an economic assessment of a multimodal transport network for single pallets. A shipment-size choice model is estimated to calculate the shippers’ reactions and their economic benefits from that transport network. In the model, the major factor influencing logistics decisions—the balance between warehouse and storage cost—is explicitly taken into account. The functional form is deduced from the first-order condition of the minimization problem of total logistics cost. Transport cost is expressed in the form of a complex function depending on shipment size and transport distance in order to capture the effect of economies of scale in transportation. The model parameters are estimated based on empirical data from two major German corporations. Simulations show that the new intermodal transportation system has a significant impact on the shipment-size distributions changing them in favor of smaller shipments. This leads especially to significant reductions in warehouse costs. Finally, some implications of the analytical results on transport policy are provided: To foster green logistics and achieve further modal shifts from road to rail, public financial support and the regulatory framework have to enable railways to consolidate small and logistics demanding shipments at an industrial scale.
PROCESS TO ENHANCE COLORATION OF UHMWPE ARTICLE, THE COLORED ARTICLE AND PRODUCTS CONTAINING THE ARTICLE

Process for enhancing the color intensity of a colored molded UHMWPE article comprising the steps of a) providing an UHMWPE, a coloring agent and a color enhancer, b) molding the UHMWPE into a molded article, c) adding the color enhancer to the UHMWPE before or during the molding step and d) adding the coloring agent to the UHMWPE before, during or after the molding step, wherein the color enhancer is a material with a hardness higher than the hardness of the molded article measured in the absence of the color enhancer.