SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Integrated analysis of regulatory networks modulating seed coat permeability in natural accessions

The European seed market is in constant expansion and improving seed quality is a key factor towards meeting the increase in demand. The seed coat is constituted from multi-cell layers that surround the embryo that will become the future plant. Seed coat properties and composition have a significant impact on seed quality. Notably, mutant seeds with permeable seed coats have defects in germination phenotypes such as lower dormancy, shorter longevity and reduced stress tolerance. The regulatory mechanisms that modulate seed coat permeability are, however, not well understood. The candidate has performed a genome-wide association study in Arabidopsis thaliana and identified ARR16 as a novel regulatory gene affecting permeability, this Arabidopsis thaliana response regulator (ARR) is a signaling component for the plant hormone, cytokinins (CKs).
	The project objective is to determine the transcriptional network involving ARR16 that controls permeability in natural accessions. In work package 1 (WP1), the spatio-temporal expression of ARR16 will be examined in seed tissues of permeable and non-permeable accessions with GFP reporter lines. Also, we will generate mutants with CRISPR/Cas9 gene edited haplotype copies, aiming to precisely define the cis-elements in the ARR16 promoter that determine seed permeability. Next, cytological analyses will be carried out on seed coats of ARR16 mutants to ascertain the composition and structural basis of the modified permeability (WP2). Finally, transcriptomes of mutant and wild-type seed coat cells isolated by laser microdissection will be analyzed, aiming to reveal CKs signaling networks mediated by ARR16 in seeds (WP3). The proposed project is feasible and appropriate for a Marie Skłodowska-Curie Individual Fellowship since the expected outcomes are innovative and generate knowledge for both fundamental and industrial research, while the candidate will improve his skills and knowledge of a specialized research area.
WHEEL SUSPENSION FOR A TWO-TRACK MOTOR VEHICLE

The invention relates to a wheel suspension for a two-track motor vehicle, wherein a wheel carrier (2) carrying a vehicle wheel is hinged to a vehicle body (3) of the vehicle by means of check rails (14, 16, 18, 20, 22), said check rails (14, 16, 18, 20, 22) being hinged to wheel carrier side hinge points on the wheel carrier (2) and to body-side hinge points (A1, A2, A3, A4) without intermediate arrangement of an auxiliary frame on the vehicle body (3). According to the invention, at least one check rail (16, 18, 20) is mounted having the body-side hinge point (A2, A3, A4) thereof on a decoupling element (4; 25). The decoupling element (4; 25) is vibration-decoupled from the vehicle body (3) by intermediate placement of at least one elastomer layer (7.1, 7.2, 7.3; 7).
Beneficial effects of nontoxic ozone on H2O2-induced stress and inflammation

In this study, the anti-oxidant and anti-inflammatory efficacy of ozone oxidative preconditioning (OOP) were investigated on hydrogen peroxide (H 2 O 2 )-induced human lung alveolar cells. In MTT and trypan blue viability tests, while 100 μmol/L H 2 O 2 caused a 17.3% and 21.9% decrease in the number of living cells, respectively, ozone at 20 μmol/L regenerated cell proliferation and prevented 9.6% and 11.0% of cell loss, respectively. In addition, H 2 O 2 decreased the transcription levels of catalase (CAT), glutathione peroxidase (GPx), and superoxide dismutase (SOD) 5.43-, 2.89-, and 5.33-fold, respectively, while it increased Bax, NF-κβ, TNF-α, and iNOS expression 1.57-, 1.32-, 1.40-, and 1.41-fold, respectively. Ozone pretreatment, however, increased CAT, GPx, and SOD transcription levels 7.08-, 5.17-, and 6.49-fold and decreased Bax, NF-κβ, TNF-α, and iNOS transcriptions by 1.25-, 0.76-, 3.63-, and 7.91-fold, respectively. Moreover, intracellular glutathione (GSH) level and SOD activity were decreased by 46.2% and 45.0% in the H 2 O 2 treatment group, and OOP recovered 58.5% and 20.1% of the decreases caused by H 2 O 2 . H 2 O 2 also increased nitrite levels 7.84-fold, and OOP reduced this increase by half. Consequently, OOP demonstrated potent anti-oxidant and anti-inflammatory effects on in vitro model of oxidative stress-induced lung injury.
Supersolids and beyond: exploring new states of matter with laser-cooled dipolar molecules

Quantum mechanics becomes most fascinating when its counterintuitive phenomena are observable on a macroscopic scale. The goal of this project is to realize and study novel states of matter that are paradigmatic examples of such behaviour.

My primary focus is the paradoxical supersolid state of matter, which combines the crystal structure of a solid with the frictionless flow of a superfluid. The very existence of this state has been debated intensively for over 60 years. After decades of inconclusive efforts in helium, I have recently observed evidence for this state in magnetic quantum gases. This discovery has raised a plethora of new questions, which can be addressed with neither magnetic atoms nor helium, and thus require fundamentally new experimental approaches.

In this project I will use laser-cooled dipolar molecules to explore supersolidity far beyond the state of the art. Starting from an ultracold gas of molecules, I will study - from few to many-body - long-discussed scenarios for supersolidity. The use of flexible optical potentials will allow me to investigate the role of doping, defects, dimensionality and disorder on the formation and dynamics of a supersolid. By using high-resolution, single-molecule imaging, I will be able to follow the corresponding dynamics down to the most elementary level, where correlations and entanglement become accessible.

A particular significant generalization of this scenario arises when the spatial ordering competes with magnetic ordering. The molecules employed exhibit both electric and magnetic dipole moments and thus naturally feature the additional degree of freedom required to realize spin models. This will enable studying further exotic states of matter in which topological effects are expected to emerge.

The extraordinary clean and tunable experimental approach will facilitate a precise comparison with theory, and thus promises unprecedented insights into the nature of these new states of matter.
Method for dividing substrate

The present invention aims at providing a method for dividing a substrate that is capable of dividing each substrate into chips in the same square-like form without causing chip breaking and capable of forming all cleaved facets flat. In the method for dividing a substrate of the present invention, an electron beam 1 with the intensity that causes a dislocation inside the substrate is irradiated to a substrate surface 2 to generate a crack starting from such dislocation, and a cleaved facet 5 is formed to divide the substrate.
Inhibiting effect of Al(OH)3 and Mg(OH)2 dust on the explosions of methane-air mixtures in closed vessel

The inhibiting effect of Al(OH)3 and Mg(OH)2 dust on explosion of methane-air mixtures was investigated by means of explosion parameter tests in a 20-liter closed vessel. The influences of varying methane concentration and dust concentration on explosion parameters were characterized based on the experimental data to determine the maximum explosion pressure, maximum rate of pressure rise, lower explosion limits and upper explosion limits. The inhibiting mechanisms of these kinds of dust were analyzed as well. The investigations indicate that Al(OH)3 and Mg(OH)2 dust can be used as inhibitors to prevent methane explosion, however, their inhibiting effects are less than those of inert gas such as N2 and CO2 in that their dust can weaken the methane explosion but cannot totally eliminate it. The tests show that all of the explosion parameters with dust additives are strongly dependent on methane/air ratio and dust concentration, and Al(OH)3 dust has better performance than Mg(OH)2 dust in inhibiting methane explosion. The average percentage decreases of maximum explosion pressure and maximum rate of pressure rise with Al(OH)3 dust are 11.08% and 66.15%, respectively. Experiments also showed that there is a special phenomenon when methane explosion is inhibited by Al(OH)3 and Mg(OH)2 dust, in which is that during the process of explosion the maximum explosion pressure value first decreases then increases as dust concentration increases. The best dust concentrations to inhibit the explosion are 250 g/m3 with methane/air ratio at 9.5%, and 200 g/m3 with methane/air ratio at 7%. It is suggested that water vapor produced by the thermal decomposition of metal hydroxides makes the particles of descending dust combine, resulting in a decrease of the real dust concentration in the vessel. Water vapor also is the major cause of another phenomenon that the LEL curve and the UEL curve never meet with the increase of gas concentration.
ADAPTAR-RAM

O projeto demonstra o impacto do apoio na estrutura dos custos da empresa, no que concerne à adaptação do seu estabelecimento face às novas condições de distanciamentofísico e de higiene, garantindo o cumprimento das normas estabelecidas e das recomendações das autoridadescompetentes.
Teyme eye vineyard sprayer

Agricultural technology is among the most revolutionary and impactful areas of modern technology driven by the fundamental need for feeding an ever-growing population. Its development has to serve the agriculture that is environmentally sustainable and cost competitive. That means fewer pesticides application, less water consumption and more efficient use of machines. Excessive use of pesticides for the suppression of insect pests, diseases and weeds has significant impact on the human health and environment. It is estimated that about 50% of all pesticides applied do not reach their intended target consequently increasing negative impact on environment, but also production costs thus implying that application of pesticides have to bedone with higher accuracy. Agriculture production cost is furthermore burdened by high cost of crop protection, particularly in grapes and other fruits growth. In permanent and close cooperation with fruit growers TEYME has recognized the mentioned challenges and developed technology to enable reducing the use and negative impact of pesticide. TEYME has improved the existing state of the art pneumatic sprayers for vineyards by patented spraying technology supported by guidance system based on video input. The control system is capable of controlling the spraying rate of individual spraying nozzles based on video input algorithms. Machine vision algorithms are providing information about canopy, foliage density and all necessary data that not only guide the process of spraying but also provide vital data for farmer such as growth rate and health status of the vineyard. TEYME's solution under TEVINS brand name will decrease use of pesticides in vineyard and orchard up to 60% and reduce it operations cost up to 25%. Project Commercial objective is to generate in 8 years of commercialization cumulative revenue of above €58 million and more than 70 new jobs created.
Fuel poverty as injustice: Integrating distribution, recognition and procedure in the struggle for affordable warmth

Bringing attention to fuel poverty as a distinct manifestation of social inequality has asserted the place of affordable warmth in the profile of contemporary rights and entitlements. As such, fuel poverty can be understood as an expression of injustice, involving the compromised ability to access energy services and thereby to secure a healthful living environment. In this paper, we consider how fuel poverty may be aligned to various alternative concepts of social and environmental justice. Whilst recognising that fuel poverty is fundamentally a complex problem of distributive injustice, we argue that other understandings of injustice are also implicated and play important roles in producing and sustaining inequalities in access to affordable warmth. Addressing fuel poverty has to involve seeking justice in terms of the cultural and political recognition of vulnerable and marginalised social groups and pursuing procedural justice through opening up involvement and influence in decision-making processes. We make this argument both in theoretical terms, and through considering the experience of fuel poverty advocacy and policy development in the UK. Opportunities for future action may be illuminated through such interconnected justice framings as wider awareness of energy, climate and poverty issues emerge.
METHOD AND APPARATUS FOR TREATING VALVULAR DISEASE

An apparatus for treating or preventing a valvular disease, said apparatus comprising : - a ultrasound probe (2) located externally to a heart (H) of patient ( P), able to produce ultrasound waves focused inside said heart and suitable to generate, at a focal spot, a pressure sufficient to result in cavitation, - an imaging device (4) for mapping in real time a treatment region (C) of a cardiac valve of the patient, said treatment region comprising at least one leaflet of the cardiac valve, - a controller (5, 7, 8 ) configured for driving the ultrasound probe to emit a sequence of focused ultrasound waves, the controller being further configured for steering the focused ultrasound waves so as to scan the entire treatment region to soften the tissues of the treatment region. A method for treating or preventing valvular disease, carried out using said apparatus.
Electron-phonon-plasmon interaction in MBE-grown indium nitride - A high resolution electron energy loss spectroscopy (HREELS) study

We studied InN (0001) grown by plasma assisted molecular beam epitaxy (PAMBE) with high-resolution electron energy-loss spectroscopy (HREELS) after vacuum transfer thus avoiding any further surface preparation. We were able to detect for the first time besides the Fuchs-Kliewer surface phonon ω0 two plasmarons ω– and ω+, which originate from the coupling between surface optical phonons ωSO and plasma oscillations of free electrons resulting from the surface accumulation layer and/or the bulk conduction band. Using dielectric theory we get new insight into the space charge regime of InN grown by MBE. We choose an approach that reaches far beyond the accumulation layer regime. Using a very wide primary beam energy regime from 1 eV up to 200 eV, the depth of information can be varied from extremely surface sensitive to bulk sensitive. Best agreement has been obtained for a downward band bending of 0.9 eV and a peak accumulation layer density of 6.5 × 1019 cm-3 at 2 nm beneath the surface with an unintentional doping of the bulk of 1 × 1019 cm-3. The sheet density of the ionized surface states is determined to Nss = 1.8 × 1013 cm-2 from the self-consistent calculation of the conduction band profile. The presented results provide important information for future InN-based devices. (© 2010 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim)
Tenofovir-based pre-exposure prophylaxis for HIV prevention

Topical tenofovir gel and oral tenofovir and emtricitabine-tenofovir [FTC/tenofovir disoproxyl fumarate (TDF)] have been demonstrated to have efficacy in preventing HIV-1 in some populations. Preexposure prophylaxis (PrEP) trials and future directions are summarized.Pericoital use of 1% tenofovir gel in the CAPRISA 004 study reduced HIV-1 acquisition by 39% and herpes simplex virus-2 acquisition by 51%. Daily oral FTC/TDF demonstrated 44% reduction in HIV-1 acquisition among MSM in the iPrEx study (Pre-Exposure Prophylaxis Initiative). Both studies showed higher efficacy among those with higher adherence. Efficacy of daily oral TDF and FTC/TDF was 66 and 73%, respectively, among HIV-1-uninfected partners in an HIV-1 serodiscordant partnership in the Partners PrEP Study. Efficacy of daily oral FTC/TDF was 66% in young heterosexuals in Botswana in the TDF2 trial. The FEM-PrEP and VOICE (Vaginal and Oral Interventions to Control the Epidemic) studies in African women found no efficacy with oral FTC/TDF and TDF, respectively. Safety and tolerability were excellent and limited resistance was observed in seroconverters.Topical tenofovir gel showed efficacy in African women and daily oral TDF and FTC/TDF were efficacious in MSM, and African HIV-1 serodiscordant couples and young heterosexuals. The reasons for lack of efficacy of oral FTC/TDF and TDF in two studies in African women are being investigated. Longer-acting formulations, invtravaginal rings, and new candidate antiretrovirals are being evaluated for pre-exposure prophylaxis (PrEP).
Dynamic regulation of tissue response by matrix viscoelasticity

The mechanical properties of the extracellular matrix (ECM) regulate processes during development, cancer and wound healing. The vast majority of research efforts in this field have been focused on ECM’s elasticity as a leading determinant of cell and tissue behaviour. However, the ECM is not merely elastic but is instead both viscous and elastic. Due to its viscoelastic nature, the ECM response to mechanical loads is inherently dynamic and evolves with time, independently of matrix degradation or remodelling. Despite the universality of ECM’s viscoelasticity, how viscoelasticity affects tissue function is unknown. Based on our preliminary data, cellular behaviour diverges significantly between viscoelastic and elastic ECMs. We hypothesize that viscoelasticity dominates tissue response. Our objective is to determine the biophysical and molecular mechanisms that regulate viscoelasticity sensing and mechanotransduction in 3D and understand its implications in cell and tissue response. To address, we will use an integrative approach that will combine 3D materials with exquisite control of viscoelastic properties, systematic molecular perturbations, computational modelling and precise quantitative analysis of cellular properties, forces and stresses. While using these tools, we will unravel the molecular mechanisms that regulate viscoelasticity response at single-cell and collective level. We will determine the dynamic role of viscoelasticity in breast homeostasis, malignant transformation and invasion. Finally, we will validate the implications of viscoelasticity by measuring breast ECM’s viscoelastic properties and with in vivo experiments. We expect that this project will unravel novel mechanosensing mechanisms operating at the roots of biological responses. These mechanisms, due to the inherent viscoelastic nature of tissues, will affect many biological fields from morphogenesis to cancer, and applied fields such as tissue engineering and biomaterials design.
METHOD AND APPARATUS FOR FORMING PARTICLES INTO SHAPED ARTICLES

Method and apparatus for forming fine, relatively dry particles into shaped refractory, ceramic and porcelain preforms or similar compacted articles by confining the loose particles in a shaped enclosure having at least one movable, preloaded side to maintain the particles in a loose but contiguous mass, accelerating the mass of particles and at least a portion of the mold in such a manner as to induce a positive or negative acceleration of the mass of a magnitude at least 25 to 50 g"s, depending upon the particle composition, and preferably in the range of 500 g"s, or greater, again depending on the particle composition, in order that each particle undergoes a force generating impact with adjacent particles to homogenously compact and fuse the adjacent particles one to the other in a nonbridging manner. A preferred apparatus (20) for accomplishing the abrupt acceleration and deceleration of the particles comprises a mold (10) having fixed sidewalls (11) and at least one movable end wall (13) positioned on a vertically oscillating table (21) and confined above the table (21) by an underdamped system tuned to a frequency corresponding to the frequency of oscillation of the table (21), and preferably including a pneumatic cylinder (30) and a punch member (12) to provide the desired preload to the mass. In operation, the pneumatic cylinder (30) and overload structure are tuned to reciprocate with the mold (10) approximately 180o out of phase with the table (21) such that the mold (10) is accelerated upward by the table (21) upon impact of the mold (10), descending pneumatic cylinder (30) and punch (12) with the table (21) in order that the particles are abruptly accelerated and/or decelerated thereby generating compacting and fusing forces at each particle throughout the particle mass.
Multi-layer agent-based architecture for smart grid reconfiguration

Smart grids are an essential tool for efficient management and monitoring of electric power. In this area, distributed programming techniques help to optimize the production and distribution of electrical energy in order to balance supply and demand to ensure better services. In this paper an agent-based distributed architecture for supervision and control of Smart Grids is proposed. The information comes from the equipment installed in the secondary substations of distribution networks of medium and low voltage. It is exchanged through a real-time middleware and processed through a multi-agent system. One of the most important tasks implemented in the multi-agent system focuses on fault detection and automatic network reconfiguration. This process allows minimizing power losses and loading balancing in the distribution network. To accomplish this task Particle Swarm Optimization (PSO) algorithm is applied.
SANITARY INSTALLATION WITH A FLOOR-CLEANING SYSTEM

In order to create a sanitary installation with an alternative floor-cleaning system for automatically cleaning the sanitary-installation floor, the invention proposes a sanitary installation (10) with a panel-like floor (40) and a floor-cleaning arrangement (44), the floor (40; 146; 172) and floor-cleaning arrangement (44) moving relative to one another as they clean the floor (40).
Review of challenges in reliable electric power delivery to remote deep water enhanced oil recovery systems

This paper reviews the major challenges involved in reliable electric power delivery to remote deep water enhanced oil recovery (EOR) systems. As the oil well matures, top side based booster systems are not economical, and hence, subsea based booster systems are required. Such EOR processes require subsea systems to be operated at varying power and voltage levels, and this requires establishing subsea power stations with long tiebacks from the shore. Subsea stations carry out safe voltage step-down, distribution and conversion of electrical power in the order of mega watts. Breakdowns in subsea based EOR systems lead to huge production losses, and system retrieval for repair and maintenance is very costly and time consuming, and therefore systems need to be highly reliable. This paper describes the technical challenges involved in subsea variable speed motor drives, long step out power transmission, subsea energy storage requirements for safe start up and emergency shutdown, thermal and humidity management inside pressure rated enclosures, fault localization, pressure tolerant electronics and bio-fouling. Emerging advancements in electrical, power electronic, power transmission, energy storage and packaging technologies are reviewed, giving the confidence that the present technical maturity would be able to drive the development of reliable subsea based EOR systems.