SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Druggable small molecule inhibitor of meis proteins

MEISi is the first innovative product of Meinox as a druggable substance, owing to its years of research on MEIS biology (published in prestigious journals like Nature and Cell Stem Cell, and PCT patented - pending national entry in 44 countries). Meinox targets the deadliest noncommunicable diseases (NCDs); cancer, CVDs and diabetes, together accounting for nearly 71% of all deaths globally. Never ending efforts and global targets in tackling these diseases show the importance of the development of more effective therapeutics. 

MEISi is a druggable target-based small molecule, developed and validated by Meinox. MEISi inhibits the activity of MEIS protein which plays a critical role in cell metabolism and associated with NCDs. The benefit it presents to the targeted drug discovery market is to provide tools to modulate molecular mechanisms of the NCDs. The massive sizes of oncology and cardiovascular drug markets (USD $ 29.3B globally) indicate the significance of the small molecule drug discovery market which motivates Meinox to target €10M market share in 3 years after commercialization.

Meinox is a deep-tech startup established in 2018 with the main focus on novel and high-level pharmaceutically active ingredients. The company aims to research, develop, produce and market first-in-class, selective drug-like small molecule inhibitors of MEIS, PBX and TGIF2 proteins and their co-factor HOXA9. 

Meinox aims to conduct a feasibility study with a risk analysis based on different market regulations. In order to improve the commercialization plan, potential customers of MEISi will be identified and strategies will be developed for each segment by defining proper channels for the MEISi product family. Market entry strategy will be validated by performing market analysis and competitive benchmarking in the target markets.
PROTECTION AND PREVENTION OF INFECTION IN RRI ACTIVITIES

THIS PROJECT AIMS AT 1) GREATER PREVENTION IN THE WORKPLACE, 2) ENSURING BUSINESS ACTIVITY IN NEW ONLINE OPERATING MODES 3)DEVELOPING SITE FOR SALE VIA E-COMMERCE
3D liver organoids: modelling host hepatitis b virus interaction

An estimated ~400 million people are chronically infected with hepatitis B virus (HBV) infection worldwide, resulting in an estimated $658 million in medical costs and lost wages annually. Although HBV disease can be prevented by vaccination, many people still become infected. Potent and safe drugs are available to eradicate HBV viral particles and clinically ‘cure’ HBV infection. However, during replication HBV delivers a very stable form of viral DNA (covalently closed circular DNA, cccDNA) in the nucleus of the hepatocyte, causing life-long risk of reactivation of HBV infection in case of suppression of the immune system (e.g. chemotherapy). Therefore the pharmaceutical industry is now aiming to develop strategies to eradicate the virus from the infected liver completely. Such studies are hampered by the lack of appropriate in vitro or animal models due to the narrow tropism of HBV for human hepatocytes. The hypothesis of the project is that creation of 3D culture systems encompassing hepatocytes, hepatic stellate cells (HSCs) and liver sinusoidal endothelial cells (LSECs) derived from an inexhaustible source of cells (human pluripotent stem cells (PSCs)) in a matrix that mimics the biophysical and biochemical features of the liver, will be a superior model for the study of HBV infection and evaluation of the efficacy of antiviral drugs.  We also hypothesize that such 3D organoids will improve maturation and function of hepatocytes, HSCs and LSECs.
The proposed studies are highly interdisciplinary, merging expertise from biology, to biophysics and engineering, with inter-sector mobility, networking, collaboration and knowledge transfer between academia and industries. The knowledge developed will be disseminated by presentations at consortium meetings, international conferences and in peer publications. All these aspects will train the researcher as independent thinker, more knowledgeable in scientific research which will provide an enormous boost to his carrier.
Adjuvant atezolizumab versus placebo for patients with renal cell carcinoma at increased risk of recurrence following resection (IMmotion010): a multicentre, randomised, double-blind, phase 3 trial

Background The standard of care for locoregional renal cell carcinoma is surgery, but many patients experience recurrence. The objective of the current study was to determine if adjuvant atezolizumab (vs placebo) delayed recurrence in patients with an increased risk of recurrence after resection. Methods IMmotion010 is a randomised, double-blind, multicentre, phase 3 trial conducted in 215 centres in 28 countries. Eligible patients were patients aged 18 years or older with renal cell carcinoma with a clear cell or sarcomatoid component and increased risk of recurrence. After nephrectomy with or without metastasectomy, patients were randomly assigned (1:1) to receive atezolizumab (1200 mg) or placebo (both intravenous) once every 3 weeks for 16 cycles or 1 year. Randomisation was done with an interactive voice-web response system. Stratification factors were disease stage (T2 or T3a vs T3b–c or T4 or N+ vs M1 no evidence of disease), geographical region (north America [excluding Mexico] vs rest of the world), and PD-L1 status on tumour-infiltrating immune cells (<1% vs ≥1% expression). The primary endpoint was investigator-assessed disease-free survival in the intention-to-treat population, defined as all patients who were randomised, regardless of whether study treatment was received. The safety-evaluable population included all patients randomly assigned to treatment who received any amount of study drug (ie, atezolizumab or placebo), regardless of whether a full or partial dose was received. This trial is registered with ClinicalTrials.gov, NCT03024996, and is closed to further accrual. Findings Between Jan 3, 2017, and Feb 15, 2019, 778 patients were enrolled; 390 (50%) were assigned to the atezolizumab group and 388 (50%) to the placebo group. At data cutoff (May 3, 2022), the median follow-up duration was 44·7 months (IQR 39·1–51·0). Median investigator-assessed disease-free survival was 57·2 months (95% CI 44·6 to not evaluable) with atezolizumab and 49·5 months (47·4 to not evaluable) with placebo (hazard ratio 0·93, 95% CI 0·75–1·15, p=0·50). The most common grade 3–4 adverse events were hypertension (seven [2%] patients who received atezolizumab vs 15 [4%] patients who received placebo), hyperglycaemia (ten [3%] vs six [2%]), and diarrhoea (two [1%] vs seven [2%]). 69 (18%) patients who received atezolizumab and 46 (12%) patients who received placebo had a serious adverse event. There were no treatment-related deaths. Interpretation Atezolizumab as adjuvant therapy after resection for patients with renal cell carcinoma with increased risk of recurrence showed no evidence of improved clinical outcomes versus placebo. These study results do not support adjuvant atezolizumab for treatment of renal cell carcinoma. Funding F Hoffmann-La Roche and Genentech, a member of the Roche group.
Wound healing ilya-style 2

ILYA PHARMA AB is a Swedish spin-out biotech company from Uppsala that develops next-generation biologics to treat wounds in skin and mucosa.

In the previous SME Instrument project, the Company reached the First in Human (FiH) Phase I clinical trial in the development of their technology platform (ILP) that utilizes chemokines as therapeutic agents through local administration from genetically modified lactic acid bacteria.

The WHILYAS-2 project addresses several critical problems and unmet medical needs related to the treatment of chronic wounds, both from patients and healthcare perspectives, namely the pandemic of obesity and diabetes (463 million people in 2019), an alarming pace of antibiotic resistance spreading (due to overuse of antibiotics), limited and insufficient treatment options (less than 25% of chronic wounds heal within 12 weeks), and vast and growing socio-economic burden (20 billion EUR per year in the US and Europe alone).

The technical, industrial, legal, and commercial feasibility of ILP100 Topical have all been confirmed over the course of our previous activities and developments.

In this project, Ilya Pharma intends to conduct exploratory clinical trials (Phase IIa) of their drug candidate, ILP100 Topical, in treatment of non-healing (chronic) wounds in populations with diabetes to achieve clinical Proof of Concept (PoC) in the relevant patient group. WHILYAS-2 will allow the Company to scale up and position it to be further investable for VCs and MedTech/Biopharma Companies or license ILP100 Topical to a partner capable of bringing it to the market through large-scale Phase IIb or pivotal (Phase III) clinical studies.

If these efforts are successful, ILP100 Topical is expected to be superior and best in class treatment for chronic wounds, offering ease of use, comparable to traditional wound dressings, >50% reduction of wound infections, significantly reduced 5-year mortality, as well as >50% decrease in treatment cost per wound.
INSTALLATION OF MULTI-COMPONENT FLOOR MAT

This invention relates to installation methods for a multi-component floor mat (100). The floor mat (100) typically contains a textile component (110) and a base component (150). Alignment and deployment of the textile component (110) with the base component (150) in an efficient manner is described herein.
Aparelho capaz de transformar a força das ondas marìtimas em força motriz

APARELHO CAPAZ DE TRANSFORMAR A FÈRçA DAS ONDAS MARìTIMAS EM FÈRçA MOTRIZ. Trata-se de um aparelho que, mergulhado parcialmente no mar., se beneficia do movimento ascendente das ondas, fazendo com que a força dessas massas d'água faça girar um volante. Consiste de um tubo vertical, aberto nos extremos e perfurado no costado, alêm de uma roldana, uma roda dentada provida de uma catraca, um cabo e uma corrente. Entrando no tubo a água faz a bóia subir, puxando o cabo e a corrente, a qual aciona a roda dentada. Esta faz girar um volante, que acumulando energia, regula os impulsos, possibilitando um movimento uniforme final.
MINIATURIZED THRESHOLD SENSOR

A sensor comprising a plurality of electrodes having a miniature size and a lower power consumption and a coating exterior to the electrodes, wherein the coating interacts with a target condition thereby producing a change in an electrical property of the electrodes, wherein the change is transduced into an electrical signal by the electrodes. Further a system for medication delivery comprising such sensor and a pill.
Influence of irritable bowel syndrome on treatment outcome in gastroesophageal reflux disease.

To investigate the influence of irritable bowel syndrome (IBS)-like symptoms on treatment outcomes with pantoprazole in gastroesophageal reflux disease (GERD) in a real life setting.For this prospective, open-label, multinational, multicentre study, 1888 patients assessed by the investigators as suffering from GERD were recruited. The patients were additionally classified as with or without IBS-like symptoms at baseline. They were treated with pantoprazole 40 mg once daily and completed the Reflux Questionnaire™ (ReQuest™) short version daily. Response rates and symptom scores were compared after 4 and 8 wk of treatment for subgroups defined by the subclasses of GERD [erosive (ERD) and non-erosive reflux disease (NERD)] and the presence of IBS-like symptoms.IBS-like symptoms were more prevalent in NERD than in ERD (18.3% vs 12.7%, P = 0.0015). Response rates after 4 and/or 8 wk of treatment were lower in patients with IBS-like symptoms than in patients without IBS-like symptoms in both ERD (Week 4: P < 0.0001, Week 8: P < 0.0339) and NERD (Week 8: P = 0.0088). At baseline, ReQuest™ "lower abdominal complaints" symptom scores were highest in NERD patients with IBS-like symptoms. Additionally, these patients had the strongest symptom improvement after treatment compared with all other subgroups.IBS-like symptoms influence treatment outcome and symptom burden in GERD and should be considered in management. Proton pump inhibitors can improve IBS-like symptoms, particularly in NERD.
Genotoxic, phytotoxic and protective effects of Portuguese propolis

Propolis is a mixture produced by bees (Apis mellifera L.) from various plant sources with a diverse
chemical composition including many bioactive phenolic compounds and terpenes characteristic of plant secondary
metabolism. The bees use propolis mainly as a sealant for cracks in the beehive, but it has been used in human folk
medicine for several millennia. A renewed interest in its study emerged in recent years due to the increasing popularity
of natural products in foods, beverages and medicines.
Propolis extracts have been associated with varied biological activities, like antioxidant, antimicrobial and
anti-inflammatory among others, and indicated for the treatment of several pathologies such as cancer or
neurodegenerative diseases. Portuguese propolis, usually regarded as a by-product without any value in apiaries,
remains insufficiently studied, hence the need for a better characterization of its properties.
In this study Portuguese propolis samples from different apiaries and different collection dates were
selected and ethanolic and n-hexane extracts were prepared and tested using a yeast (Saccharomyces cerevisiae) and in
vitro flax (Linum usitatissimum) cultures as models. Viability assays with yeast cells and plant growth analysis were
performed to assess extracts toxicity. The yeast model was used to investigate mechanisms of cytotoxicity by the
mitochondrial membrane potential-targeting fluorochrome rhodamine 123 approach and to evaluate genotoxicity by the
comet assay. The in vitro plant model was used to evaluate extracts effects at the multicellular developmental level as
well as in the photosynthetic function by pulse amplitude modulated fluorometry. Both photoinhibitiory and
photoprotective potential against oxidative damage of the extracts were investigated using plants grown under high light
intensities. Extracts antioxidant properties were also studied in yeast by flow cytometry using the redox-sensitive
fluorochrome dichlorofluorescein diacetate.
Our results suggest that ethanolic extracts from Pereiro and Povoa do Varzim apiaries are among the most
toxic for both yeast and plants. They decrease yeast viability and mitochondrial membrane potential and dramatically
affect early plant development inhibiting particularly root growth, photosynthetic efficiency and increasing nonphotochemical
quenching in a dose-dependent manner. Significant genotoxicity was found only in ethanolic extracts
from Pereiro collected in 2010, also one of the most toxic in both models tested. However, some ethanolic extracts were
also able to revert oxidative-induced damage. They reduced intracellular oxidation induced by hydrogen peroxide in
yeast, and greatly recovered the total chlorophyll content reduced by high-light-induced photooxidative stress. Here, also
n-hexane extracts were effective.
Globally our results are in line with the antioxidant properties revealed by propolis worldwide but also
underline the strong toxicity in different cellular models suggesting that eukaryotic universal…
The role of social behaviour in mate choice

Cooperation is at the very base of our society and it has been argued that the adoption of cooperative breeding by our hominin ancestors provides the most parsimonious explanation for the origin of human hyper-cooperation. In addition, in humans, cooperation seems to bring not only kin benefits but also sexual benefits by influencing partner choice. Whether cooperative behaviour also influences partner choice in wild animals remains almost unknown. Two powerful tools will be used in this project, SOCIAL MATCH, to answer this question. First, statistical analyses of a long-term database including both cooperative behaviour and mating success and, second, new technologies to determine if and how cooperative behaviours can be sexually selected. In my project SOCIAL MATCH, I will focus on the cooperative behaviours of a natural population of a passerine under long-term investigation, the Sociable Weaver (Philetairus socius). I will test the predictions that if cooperation brings sexually selected benefits then it should be linked to mating success, condition and should be advertised. I will measure condition developing automated detection of individual mass. I will quantify the vocal behaviour of cooperating birds using on-board miniature microphones and classify the obtained vocalizations with machine learning algorithm. With the acquired information I will be able to design a playback experiment to explore the links between vocal advertisement of cooperation and probability of finding a mate. Therefore, I will quantify every step from the decision of helping to the breeding phase. Despite their explicit evolutionary relevance, the consequences of sexually selected direct benefits on promoting and maintaining cooperation have remained largely unexplored. SOCIAL MATCH aims to be a keystone project in the path of resolving these questions.
SYSTEM FOR DISTRIBUTING ELECTRICAL POWER IN MOBILITY

A system (100) for distributing electrical power in roaming, comprising: - at least one device (1) for supplying electrical power in roaming provided with means (2) for connection to a source of electrical power (E) and a power socket (3) for supplying the electrical power, means (6) for interrupting electrical continuity, communication means (7) for allowing the communication with at least one external electronic device (300) and one or more sequences of computer instructions (S1) adapted to switch the interruption means (6) so as to allow the supply of electrical power following a control signal (C) sent by the external electronic device (300); - a management computer apparatus (200) provided with a database (DB) which includes information regarding users in roaming and provided with one or more sequences of computer instructions (S2) configured to send information (I) regarding a specific user to the aforementioned external electronic device (300); - such electronic device (300), for example a smartphone or tablet, owned by a user, configured to establish a first communication channel with such supply device (1) and with such management computer apparatus (200) so as to identify the supply device (1) and send both the control signal (C) and the information (I) received from the management computer apparatus (200) for starting the supply of electrical power thereto.
An Interference Signal Signature Analysis Algorithm Based on High Order Cumulants

A kind of signal space characteristic estimate method is proposed in this article based on higher order cumulants, which is suitable for parameter estimation of interference signal under multi-path propagation environment. By uniform linear array and its improving, we developed an analysis model of receiver that mixed signal and interference. In order to research time-frequency distribution at different interference level, third-order cumulants spectrum was employed to analysis higher order time-frequency distribution. Moreover, higher order time-frequency distribution and its time axis slice spectrum are calculated and analyzed. The simulation result indicated that higher order the frequency distribution and its slice spectrum have the higher disturbance resolution. This algorithm is suitable for willfully additive Gauss (white or colored) under the noise environment radio disturbance discriminating. The theoretical analysis and the simulation result showed the method validity and robustness.
A Human Caregiver Support System in Elderly Monitoring Facility

The number of elderly population is increasing worldwide and often they need assistance in their daily activities. In many situations, these elders are placed in elderly care facilities in order to receive continuous assistance from the human caregivers. The caregivers usually keep a watchful eye on the elders and help them in their activities of daily living. However, study shows that the human caregivers often suffer from boredom for being engaged in monitoring the elderly, which also compromises the care and assistance needed for the vulnerable elderly. In order to address this issue, we propose a human caregiver support system that aims to comprehend elderly persons' activities and decides what services to provide them in different situations and when to notify the human caregiver about any incident that happens in the care facility. Our preliminary experiment shows the potential of such system.
Drought Forecasting Using Neural Networks, Wavelet Neural Networks, and Stochastic Models: Case of the Algerois Basin in North Algeria

Drought forecasting is a major component of a drought preparedness and mitigation plan. This paper focuses on an investigation of artificial neural networks (ANN) models for drought forecasting in the algerois basin in Algeria in comparison with traditional stochastic models (ARIMA and SARIMA models). A wavelet pre-processing of input data (wavelet neural networks WANN) was used to improve the accuracy of ANN models for drought forecasting. The standard precipitation index (SPI), at three time scales (SPI-3, SPI-6 and SPI-12), was used as drought quantifying parameter for its multiple advantages. A number of different ANN and WANN models for all SPI have been tested. Moreover, the performance of WANN models was investigated using several mother wavelets including Haar wavelet (db1) and 16 daubechies wavelets (dbn, n varying between 2 and 17). The forecast results of all models were compared using three performance measures (NSE, RMSE and MAE). A comparison has been done between observed data and predictions, the results of this study indicate that the coupled wavelet neural network (WANN) models were the best models for drought forecasting for all SPI time series and over lead times varying between 1 and 6 months. The structure of the model was simplified in the WANN models, which makes them very convenient and parsimonious. The final forecasting models can be utilized for drought early warning.
Aggressive Marketing, Consumer Kids and Stereotyping of Media Contents

Abstract Marketing communications focused on the childrenś consumer sometimes include expressive elements of aggression that are explicitly shown in the advertising media texts carried out by communication media in advertising communication processes. Children are very sensitive and they make their vision of how the world works on the basis of what they see and hear. Defamation and aggressive marketing communication are highly harmful to their development. This is due to the fact that they still fail to distinguish between fiction and reality. Consequently, the gender (verbal and visual) stereotypes presented in advertising, as well as in videogames, journalism or film production, may even lead to the idea that violent relationships between the two genders are standard and that women are passive victims unconditionally accepting the dominance and violence from menś side. This article answers the following questions: 1) what is the role of stereotypes in media contents and processes of aggressive marketing, 2) how to apply stereotypes in aggressive marketing influence on the development of consumer competencies of children with respect to their cognitive and moral abilities.