SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Phronesis as a Paradigm for ICT-enabled Transparency: The Case of the Nicaragua Canal Megaproject

This paper proposes the use of Phronesis as an alternate research paradigm to inform the design of information systems that can enhance the transparency and accountability of megaprojects. We illustrate the proposed approach in the context of the Nicaragua Canal Project, a contemporary Mega-Project for which the research questions addressed by the three Aristotean intellectual virtues: episteme, techne, and phronesis, are presented and examined. We differentiate between the types of questions that can arise in investigating megaprojects and show that Phronesis is more suitable than the traditional research paradigms of Epistemology (episteme) and technology (techne) for answering the type of societalmanagerial “choice” questions that typically arise in the case of megaprojects. Therefore, phronesis can provide an appropriate framework for the design of ICT-enabled systems that can facilitate the advancement of different stakeholder values and perspectives that need to be considered in making value choices.
Intelligente grenzüberschreitende Fabriken, die über die Cloud gut zugänglich sind

Das Projekt wird ein digitales Werkzeug für Unternehmen entwerfen und entwickeln, das es ihnen ermöglicht, Mängel in der Produktionsausrüstung zu antizipieren und verfügbare Alternativen vorzuschlagen.
Discovering new disease pathways affecting mtdna metabolism

Defects of mitochondrial DNA (mtDNA) metabolism (maintenance, integrity and expression) are the most common cause of multiple mitochondrial respiratory chain (MRC) defects in children. Several new disease genes have been identified in these complex pathways but the functional link between mutant protein and mtDNA metabolism is unknown or poorly understood. Example of the latter is FBXL4 (F-box and leucine-rich repeat protein 4) gene, mutations of which have been recently found in 28 patients with a multisystem complex syndrome, hallmarked by combined MRC defect and reduction of mtDNA copy number in muscle and fibroblasts. Approximately 60% of patients still lack genetic definition of their disease. Objective of MITOBIOPATH proposal is the discovery and characterization of novel mitochondrial biogenetic and maintenance pathways by implementing three specific aims. 1) Gene discovering by whole exome sequencing (WES): unbiased WES screening will be applied to a large cohort of paediatric patients presenting early onset hypotonia, developmental delay, failure to thrive, severe encephalomyopathy and/or liver failure associated with combined MRC defects. 2) Pathogenic pathways revealed by new gene defects: functional studies using cellular and animal models (knock-out zebrafish or mouse models) will be performed to establish the pathogenic mechanism of the mutation(s) and the function of unknown disease-associated protein(s); 3) FBXL4 function in cellular and in vivo models: immortalized cell lines expressing six different FBXL4 mutations will be generated by using CRISP/Cas9 technology and characterized with a combined molecular, biochemical and proteomic approaches. In addition, proteins in the Parkin-proteasome complex were recently identified as potential partners of FBXl4, and they will be further analyzed. Knock-out mouse model of Fbxl4 will be also investigated. 
Overall results will have impact on both mitochondrial disorders and other neurodegenerative disease.
Construction about A New Generation of HIS in Jingzhou Central Hospital

Objective Through the analysis of hospital information sistem and the network structure,and trough the construction of a new generation of HIS,to explore the mode and approach of digital hospital.Methods a.Through the situation investigation of hospital existing hard software system,we put forward mode and programme of digital hospital.Trough analysis of HIS structure and software,we put forward the principle and objectives of digital hospital.b.Through programme analysis of hospital network structure,we perfected the hospital network security system,and constructed a integral and reasonable network system.Conclusion The new generation of HIS system and the consummation hospital network system have raised the hospital digitization application level,and enhanced the working efficiency and patient's degree of satisfaction.
Assessing functional communication: validation of the Italian versions of the Communication Outcome after Stroke (COAST) scales for speakers and caregivers

ABSTRACTBackground: There is an increasing need of assessing functional communication in daily activities and the impact on the quality of life from the perspective of the major protagonists of life situations following aphasia. Several instruments are available for English. One of the most recent is the Communication Outcome after Stroke scale for patients (COAST) and caregivers (Carer COAST). These scales are comprised of two components, interactive communication skills and their impact on quality of life, assessed through 20 question items, from the point of view of patient and carer. In contrast, the number of tools available in Italian is very limited.Aims: (i) To validate the COAST and Carer COAST scales for the Italian-speaking population; (ii) to explore the applicability of the COAST scales to a wider range of people with communication problems, not limited to moderate aphasia; (iii) to explore the agreement between patient’s and carer’s perspective on communication difficulties, and the effect o...
OVEN PROVIDED WITH A MEASUREMENT SYSTEM INSIDE THE FIBROUS MAT

An oven for heating a fibrous mat comprising a first conveyor (4) for conveying the mat in a forward direction, and a measurement system inside the mat, comprising a sensor mounted on said first conveyor (4) and adapted to move, in a transverse direction of the mat, between a first retracted position inside the conveyor and a measurement position inside the mat under the effect of an activation system, the measurement system being such that the sensor is connected by a mechanical transmission system (40) to a finger (54) projecting on a lateral side (4c) of the first conveyor (4), and the activation system (60) comprises at least one contact surface (64) located facing said lateral side (4c) of the conveyor (4) and adapted to engage with said finger (54), when it moves in the forward direction in order to move the sensor from its retracted position to its measurement position by means of the mechanical transmission system (40).
Early mobilization practice in a single Brazilian intensive care unit

To characterize the provision of early mobilization therapy in critically ill patients in a Brazilian medical intensive care unit (ICU) and to investigate the relationship between physical activity level and clinical outcomes.Intensive care unit and physiotherapy data were collected retrospectively from 275 consecutive patients. Here we report on the subset of patients (n = 120) who were mechanically ventilated during their ICU stay (age, 49 ± 18 years; Simplified Acute Physiology Score 3, 45 [25]).Median (interquartile range) time of mechanical ventilation and ICU length of stay were 3 (4) and 8 (10) days, respectively. Intensive care unit and 1-year mortality were 31% and 50%, respectively. During the ICU stay, these patients all received respiratory physiotherapy and 90% (n = 108) received mobilization therapy. When intubated and ventilated, mobilization therapy was performed in 76% (n = 92) of the patients with no adverse events. The most common activity was in-bed exercises (55%), and the number of out-of-bed activities (sitting out of bed, standing, or walking) was small (29%) and more prevalent in patients with tracheostomy than with an endotracheal tube (27% × 2%, respectively).In our Brazilian ICU, mobilization therapy in critically ill patients was safe and feasible; however, similar to other countries, in-bed exercises were the most prevalent activity. During mechanical ventilation, only a small percentage of activities involved standing or mobilizing away from the bed.
Ribitol-Phosphate: chemical tools to probe the biology of a unique mammalian carbohydrate

Cell-surface proteins are decorated with a variety of different carbohydrate structures that play central roles in mammalian biology. The complex nature of glycan structures and the pathways by which they are assembled make it a challenging task to decipher their exact function in cells, knowledge that is essential if we are to understand how malfunctioning leads to disease. This proposal aims to deliver innovative approaches to probe a distinct pathway of glycosylation essential to mammalian biology and to use these strategies to provide novel insights into the mechanisms underlying normal cellular functioning and disease pathology. The work programme is built around a specific type of O-linked cell-surface glycan that carries two critical ribitol-phosphate (RboP) residues, unique carbohydrates that so far have not been identified in other mammalian glycoconjugates. Failure to correctly assemble this glycan causes a range of congenital muscular dystrophies known as α-dystroglycanopathies. Despite its importance in disease pathology, many aspects of RboP utilisation and functioning in mammalian cells are poorly understood. The proposed programme offers a powerful and original approach to address these key issues in cell biology by creating a set of novel chemical tools. These tools will enable the probing and manipulation of both RboP-carrying glycoconjugates as well as the enzymes responsible for installing RboP onto the glycans in a cellular context. Integration of these tools with fundamental 3-D structural information and studies in cellular models of α-dystroglycanopathy will offer the unprecedented opportunity to directly link genetic defects to molecular and cellular aspects of enzyme function and through to observed changes in glycosylation status. These pioneering strategies will impact our fundamental understanding of key processes in mammalian cells and will also enable the exploitation of this unique pathway for the design of therapeutic strategies.
Post ALphabetical Interactive Museum using Participatory, Space-Embedded, Story-Telling

Palimpsest will introduce a new type of museum experience. When the project is fully developed, you will be able to explore urban landscapes, to activate our art installations and to immerse yourself in an interactive experience. You will be able to witness urban legends and stories come to life in a mixed reality setting.

Palimpsest project focuses on how cultural heritage assets can be reinserted in the city through digital technologies in Epirus and Puglia regions. Palimpsest addresses the common challenge of promoting tourism in less-developed areas, by animating the urban public space and recuperating cultural heritage assets through bottom-up, participatory procedures and artistic interventions.

Palimpsest will develop a localized archive of story-telling assets, which will lead to an interactive, immaterial, open-air Museum experience in the urban space of the city. The project will create a map in an App format, which will pinpoint the collected assets gathered by the participation of the elementary school pupils who will seek lost information regarding the city’s stories and legends, from elder people.

The University of Ioannina, School of Fine Arts, is the lead beneficiary of this project in cooperation with the Region of Epirus, the Municipality of Ioannina (as Associated Partner) and two Italian partners, the University of Bari and the Province of Lecce.
Conservation genomics of endangered green sea turtles

Conservation and management of marine turtle populations are challenging because of their complex life history involving long-distance migrations. Consequently, marine turtles are affected by a wide range of anthropogenic threats across temporal and spatial scales, including climate change. The cumulative effect of these impacts is likely to have direct and indirect implications on these endangered species in the near future. This project aims to refine our understanding of the spatial structure of green turtles (Chelonia mydas) in the South-West Indian Ocean to understand better how populations interact and how they may be impacted by threats both at the nesting ground, at distant foraging areas, and along migratory corridors. To do so we aim to apply the power of genome-wide Single Nucleotide Polymorphisms (SNPs) combined with traditional mtDNA markers to assess fine-scale population structure and recent demographic history. In addition, the research will take a multidisciplinary approach, combining novel genetic methods with data from movement ecology (satellite telemetry) and oceanography (ocean current modelling) to provide a comprehensive analysis of connectivity between breeding and foraging areas.  The results will allow conservation managers and policymakers to identify areas in need of protection and to assess the potential impacts of anthropogenic activities such as marine turtle interaction with fisheries. As such, our results will provide the scientific basis for future conservation actions within the framework of Integrated Maritime Policy. 

This project will allow me to gain critical new skills in conservation genomics. This will broaden my research horizon, strengthen my research profile and place me in a strong position for furthering my research career within the European Community.
Biovalley Finland

Central Ostrobothnia is known for Biovalley. The combination of chemistry, mineral economy and rural industries as a profile of smart specialisation is unique and distinguishes the region from other regions in Finland and Europe. Biovalley Finland is a support and promotion project aimed at the internationalisation of Biovalley. The aim is for Biovalley to become an internationally attractive circular economy ecosystem, creating new businesses, jobs and new investments. The result is a strong circular economy area in which three industries (chemical, primary and extractive industries) operate synergistically. The project promotes the development and implementation of smart specialisation in Central Ostrobothnia, as well as the funding and influence of provincial actors. The project supports the activities and role of the province in the EU Smart Specialisation Forums where Central Ostrobothnia is involved as a region. As a result, new contacts and new know-how will be channelled to the region. The project will jointly support the area’s content research and development as well as the product development of companies. During the project, modelling of the commercialisation process of selected new innovations in the circular economy will be created. The project makes influencer communication and produces the necessary material for joint use. Biovalley events, such as Kokkola Material Week, are a key part of promoting visibility. As a result of the project, Biolaakso’s visibility will increase nationally and internationally. There are 23 partners in the Biolaakso Framework Agreement. The consortium is coordinated by Chydenius, Kokkola University Centre. Biolaakso’s cooperation agreement will be renewed and the Consortium’s operations will be established as a permanent operating model. Biolaakso’s Advisory Council is internationalising. The project has positive effects on the region’s attractiveness, employment, internationality and new circular economy value chains.
Multiscale analysis of precipitate in al-cu alloys

Al-Cu alloys have a wide range of engineering applications due to their low density and high strength provide by a fine dispersion of nm-sized precipitates. The optimization of the mechanical properties of these alloys has been traditionally carried out through costly experimental “trial-and-error” approaches. In this project, a novel methodology is presented to determine the precipitate structure resulting from high temperature ageing and the resulting strength of the alloys from first principles calculations. The strategy is based in two main pillars. The first one is the determination of the Al-rich part of the Al-Cu phase diagram by means the construction of effective cluster expansion Hamiltonians that can extrapolate first-principles calculations in combination with statistical mechanics approaches based on Monte Carlo simulations to include the entropic contributions, enabling parameter-free predictions of the phase diagram. The second one is the combination of this information with phase field modeling to predict the homogeneous and heterogeneous nucleation and growth of precipitates during high temperature ageing and with molecular dynamics and dislocation dynamics simulations to predict the strengthening provided by the precipitates. The approach developed in this proposal will improve the predictive power of Integrated Computational Materials Engineering in Al-Cu alloys. The applicant will transfer her expertise and international connection in the field of multiscale modelling to the host institute. She will work with researchers of the host institution to prompt new areas of research that can attract new funding and receive regular training on transferable skills. All these activities will enlarge her portfolio of skills and will ensure further development of her career.
Ground-based CCD astrometry with wide field imagers - IV. An improved geometric-distortion correction for the blue prime-focus camera at the LBT

High precision astrometry requires an accurate geometric-distortion solution. In this work, we present an average correction for the blue camera of the Large Binocular Telescope which enables a relative astrometric precision of ~15 mas for the and V Bessel broad-band filters. The result of this effort is used in two companion papers: the first to measure the absolute proper motion of the open cluster M 67 with respect to the background galaxies; the second to decontaminate the color-magnitude of M 67 from field objects, enabling the study of the end of its white dwarf cooling sequence. Many other applications might find this distortion correction useful.
VALVE

A vale (1) for restricting and closing plastic tubing, comprising a base (2) having a surface (10) for holding a plastics tube, two side guides (6,8) extending from the base, a top (4) provided with a restriction member (12) and means (20,22) for raising and lowering the restriction member on to a seat (10) . One of the side guides (8) is pivotally connected to the base and connectable to the top. The top having a bifurcation (34) to accept the guide, a seat (36) being provided on the bifurcation to hold a head (30) on the side guide. The valve can be placed round a plastics tube and the restriction member positioned to set the flow through the tube . To remove the valve from the tubing, depression of the top releases the head of the side guide from its seat opening the valve .
CIRCULAR ECONOMY for Start-ups

The common challenge of ECO-CIRCuS is to quantitatively and qualitatively increase new MSMEs in the blue and green supply chains using the “Contest” model for the provision of advanced services aimed at supporting the transition towards a circular economy. The main changes expected concern the increase of young MSMEs (max. two years of activity or three if innovative MSMEs) that are interested in enhancing their entrepreneurial skills in order to take advantage of the opportunities offered by the EC. The project’s outputs are: an “ECO-CIRCuS” joint business plan (including the range of specialised services); a Circular Expert Task Force (cross-border pool of experts on “circular” entrepreneurship); the “CONTEST ECO-CIRCuS” call for ideas & needs, in order to select the companies that will benefit from the specialised services; Specialised services regarding "circular" entrepreneurship. The direct beneficiaries will be new cross-border MSMEs that are already active in the blue and green supply chains and that are interested in increasing their competitiveness through the ability to introduce or implement “circular” micro-eco-innovations. ECO-CIRCuS encourages the spread of new businesses based on the circular economy, which are defined and implemented based on social and open innovation methods in order to ensure the right balance between the "need for innovation" and "protection of local identities". The cross-border approach maximises the benefits that can be achieved by “circular” business models because: 1) it allows for resource optimisation within the individual supply chains and between supply chains; 2) it nurtures creative processes and collaboration through territorial cross-contamination. Innovative aspects: implementation of social and open innovation processes; joint business plan for the development of “circular” entrepreneurship; cross-border provision of services for innovation and entrepreneurial training on the e.c; definition and initial implementation of new businesses connected to the e.c.
Short-term and Long-term Postoperative Safety of Off-Pump versus On-Pump Coronary Artery Bypass Grafting for Coronary Heart Disease: A Meta-analysis for Randomized Controlled Trials

The aim was to compare the short-term (30 days after surgery) and long-term (over 6 months' follow-up) postoperative safety of off-pump and on-pump coronary artery bypass grafting (CABG) for patients with coronary heart disease (CHD).Relevant randomized controlled trials (RCTs) were obtained from PubMed, Embase, Springer, Ovid, and Cochrane library up to July 2013. Odds ratios (ORs) with their 95% confidence intervals (CIs) were used to access effect sizes.Seven RCTs involving 9,128 patients were included. Results suggested no significant difference in all the short-term outcomes (mortality, OR = 0.90, 95% CI: 0.69 to 1.16, p = 0.41; myocardial infarction, OR = 0.95, 95% CI: 0.79 to 1.15, p = 0.61; stroke, OR = 0.78, 95% CI: 0.56 to 1.07, p = 0.12; renal failure, OR = 0.84, 95% CI: 0.60 to 1.18, p = 0.43; revascularization: OR = 1.95, 95% CI: 0.79 to 4.85, p = 0.15) and some long-term outcomes (mortality, OR = 1.02, 95% CI: 0.86 to 1.22, p = 0.81; myocardial infarction, OR = 0.86, 95% CI: 0.70 to 1.04, p = 0.12; stroke, OR = 0.89, 95% CI: 0.67 to 1.19, p = 0.44) between off-pump and on-pump CABG. However, off-pump CABG had a significantly higher revascularization rate (OR = 1.45; 95% CI: 1.02 to 2.06; p = 0.04) than on-pump CABG in long-term follow-up.Short-term postoperative safety was similar between off-pump and on-pump CABG. A high revascularization rate was the drawback of off-pump CABG for CHD patients in long-term follow-up.
Quantitative Assessment of Protein Interaction with Methyl-Lysine Analogues by Hybrid Computational and Experimental Approaches

In cases where binding ligands of proteins are not easily available, structural analogues are often used. For example, in the analysis of proteins recognizing different methyl-lysine residues in histones, methyl-lysine analogues based on methyl-amino-alkylated cysteine residues have been introduced. Whether these are close enough to justify quantitative interpretation of binding experiments is however questionable. To systematically address this issue, we developed, applied, and assessed a hybrid computational/experimental approach that extracts the binding free energy difference between the native ligand (methyl-lysine) and the analogue (methyl-amino-alkylated cysteine) from a thermodynamic cycle. Our results indicate that measured and calculated binding differences are in very good agreement and therefore allow the correction of measured affinities of the analogues. We suggest that quantitative binding parameters for defined ligands in general can be derived by this method with remarkable accuracy.