SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Electromobility in urban transport: a multi-dimensional innovation (socio-economic and environmental effects)

At present, transition towards electromobility in urban transport and related companies are among the most studied industrial areas. Different EU countries implement different methodological and business approaches to investigate the possibilities for the acceleration of electromobility integration in urban transport. Studies on these approaches to be shared within the project consortium and with different stakeholders (local authorities, producers of electric vehicles and recharging stations) will provide the basis of the initiative for increasing the interest in electromobility integration in urban transport as a multi-dimensional innovation. The thin red line of electromobility practical integration passes through the sharing of innovative ideas with relevant stakeholders by carrying out field studies, in-depth interviews and electronic on-line studies.

EMobilita overall objective is to study the conditions, prerequisites and incentives for electromobility integration in urban transport and elaboration of a roadmap for its development. The specific objectives are:
• To explore the experience of the European countries in the integration of electromobility in urban transport and to identify good practices;
• To summarize direct and indirect multi-dimensional effects (social, economic and environmental) of the introduction of electromobility in urban transport schemes;
• To elaborate a roadmap with concrete measures for introducing electromobility in urban transport;
• To establish a sustainable partnership between universities and businesses through staff exchange and networking activities.

In order to achieve our objectives we created a network of academic and non-academic institutions from Bulgaria, Slovakia, Italy and Greece.
Signaling cascades in metabolic diseases

Over 380 million people suffer from diabetes worldwide, with majority of cases being attributed to type 2 diabetes (T2D). Obesity is a major risk factor predisposing to the development of this disease. T2D is characterized by peripheral insulin resistance in combination with relative insulin deficiency that results in hyperglycemia and hyperlipidemia. Liver and adipose tissue are central for regulation of glucose and lipids levels. However, during T2D the hepatic glucose uptake is reduced while rates of gluconeogenesis and lipogenesis are increased. In the adipose tissue, T2D leads to decreased glucose uptake, perturbations in secretion of adipokines and increased lipolysis. Importantly, dysfunction of the liver and the adipose tissue during T2D is caused by defective phosphorylation signaling cascades and normalization of these pathways was shown to attenuate the course of T2D. However, the specific roles of different classes of signaling molecules in these organs remain poorly characterized. We hypothesize that the cross-talk of different classes of signaling molecules determines regulation of metabolism.
Thus, we aim to identify the signaling networks regulating metabolism. The results generated in my own laboratory suggest that the Pkd family kinases are the crucial regulators of metabolic homeostasis. Specifically, Pkd1 and Pkd2 promote obesity and diabetes while Pkd3 controls liver function. Thus, we plan to characterize the molecular mechanisms controlling Pkds signaling. In parallel, we will utilize screening approaches to identify novel, non-canonical signaling modules (phosphatases and components of the ubiquitin system) regulating abundance, localization and phosphorylation of targets of Pkds and, in the long term, also other kinases implicated in T2D.
By identifying and characterizing the essential signaling networks in liver and adipose tissue the project will contribute to more targeted pharmacological strategies for the treatment of T2D.
A SYSTEM AND METHOD FOR SCALE INHIBITION

The present invention discloses methods for inhibiting scale formation or precipitate formation in oil field flow lines and processing equipment exposed to fluid containing components that form scale or precipitates on surfaces of oil field flow lines and processing equipment, especially in highly paraffinic crude oils, where the method and system include applying an electric field across the fluid flowing through a flow line, where the fluid includes a scale or precipitate inhibitor and where the fluid strength and the inhibitor concentration is sufficient to reduce or prevent scale or precipitant formation.
Epidemiology and Importance of Renal Dysfunction in Heart Failure Patients

Renal dysfunction (RD) is a frequent comorbid condition and a major determinant of outcomes in patients with heart failure (HF). It is likely that the etiology of RD in patients with HF is much more complex than we first thought and represents a matrix of independent, albeit interacting, pathophysiological pathways with effects on both the kidney and the heart that share a common denominator: aging and inflammation. Renal dysfunction in HF has been attributed, among others, to biochemical, hormonal, and hemodynamic factors, coupled with pharmacological interventions. Regardless of the cause, the development of RD or worsening renal function is common in patients with HF, and is associated with increased morbidity and mortality. There is increasing evidence, however, that transient increases in creatinine in the setting of acute HF are not prognostically important, whereas persistent deterioration does portend a higher mortality in this patient population. In addition, congestion seems to play an important role in the course of renal deterioration, and the combination of congestion and worsening renal function is the most significant clinical prognosticator in HF patients. This review aims to provide an update on the epidemiology and prognostic significance of RD in HF patients, in both the acute and the chronic setting.
TOP PORT MICROPHONE AND METHOD FOR THE PRODUCTION OF SAME

A microphone has a housing comprising a base part and an upper part and a transducer element which is arranged in the housing and is electrically and mechanically connected to the base part. In order to install the transducer element in a zero-voltage state, a flexible connection element is proposed which is soft and elastic and/or is compressible, which is arranged between the transducer element and the upper part and which connects the transducer element to the upper part. The connection element comprises a plastic in which gas bubbles are distributed, wherein the gas bubbles in the connection element have a volume fraction between 50% and 98%.
STEP-UP/STEP-DOWN CONVERTER AS PHASE CONVERTER FOR ELECTRIC MACHINE

The present invention provides a bidirectional voltage converter. The voltage converter comprises at least four modes of operation for converting a DC voltage into a voltage for actuating an electric machine or for converting a generator voltage into a DC voltage. In this case, the respective converted voltage is smoothed and is provided so as to have a much lower noise component than in the case of conventional power controllers. The circuit design particularly allows operation at high switching frequencies. Hence, the switching frequency can be moved to a range outside the range of human hearing. Furthermore, high switching frequencies also allow a reduction in weight and required installation space for the voltage converter.
SE4Painternational? Marketing of patents for a new revolutionary analgesic of marine origin

Sea4Us is a company specialising in the discovery and development of new marine medicines. With this project, the aim is to identify opportunities to sell their patents to multinational pharmaceutical companies and to start their internationalisation process.
Cyber physical equipment for unmanned nuclear decommissioning measurements

The CLEANDEM project, with its collaboration of 11 partners from 4 EU countries, proposes a technological breakthrough associated to various dismantling and decommissioning (D&D) operational steps with an Unmanned Ground Vehicle (UGV) Platform. The CLEANDEM strategy will be based on innovative detection technology systems that will constitute a toolbox for equipping an intelligent robotic platform for fully remote operations. The pre-identified technologies are low-cost sensThe CLEANDEM project, with its collaboration of 11 partners from 4 different EU countries, proposes a technological breakthrough for dismantling and decommissioning (D&D) operations of nuclear sites, employing an Unmanned Ground Vehicle (UGV) Platform equipped with innovative radiological sensing probes. The aim of the project is to deliver a cyber physical system which will support the end-users’ operations, initially performing a radiological assessment of the area and then monitoring D&D operations throughout the final characterization of the plant. This will result in a 3D and fully detailed digital twin of the surveyed area augmented with radiological information provided by the sensors, thus enabling an efficient and effective planning of the dismantling actions and optimizing the nuclear waste sorting for reprocessing or for delivery to the final storage. Targeted impacts of the UGV Platform are to: save time, drastically reduce costs, minimize human intervention, improve workers and population safety and be greener; all of those driving the project execution to match the stakeholders’ expectation. The effectiveness of the UGV Platform will be assessed in an extensive testing and validation campaign that will be performed in laboratories, in simulated environment and finally on the field. A demonstration event in a real nuclear site, involving all project partners and external stakeholders, will conclude the three years project activities opening for further exploitation in the D&D market.
''One size fits all'' unique drug to eradicate multiple viral species simultaneously from the central nervous system of co-infected individuals

Viruses that infect the brain and other parts of the central nervous system are a worldwide threat of terrible dimensions. Viruses such as Zika, Dengue, Chikungunya, HIV or measles, for instance, and more recently the Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are responsible for thousands of victims severely impaired at neurological level each year in the world. One of the most recent large scale threats in this domain was a Zika virus outbreak in South America. Zika virus, like Dengue virus or Chikungunya virus, is spread mainly by mosquitos of the genus Aedes. While Dengue and Chikungunya viruses, as many others, might causes diseases with severe neurological disorders, Zika virus is much more dreadful in this regard. When a pregnant woman is infected, the virus is able to translocate the blood-placental barrier and then the developing blood-brain barrier of the foetus, causing microcephaly and serious neurological disorders to newly born babies.
Although co-infections with Aedes-borne viruses, such as the above mentioned Zika, Dengue and Chikungunya viruses, are likely because several viral species coexist in the same vector, the classical drug development strategies completely overlook this striking reality. Moreover, additional co-infections with HIV, SARS-CoV-2 and measles virus, using other routes of infection, are also possible. A drug able to target a very large spectrum of viral species is urgently needed.
Importantly, this drug must be able to traverse the blood-brain barrier and reach the viruses accumulated in the brain.
NOVIRUSES2BRAIN is a project that aims at finding and selecting drug leads that are both efficacious and able to translocate the blood-placental and blood-brain barriers so that Zika, Dengue, Chikungunya and other viruses, such as the recently discovered SARS-CoV-2 can be targeted across barriers, including during pregnancy. The project gathers the expertise of medicinal chemists, biochemists, drug development specialists and virologists to create drug leads able to clear all viral species from brain simultaneously.
Mixed brushes of stimuli-responsive polymers for the selective adsorption of proteins

Advanced materials are at the heart of many scientific fields, particularly in the biomedical and biotechnological areas. Many devices (e.g., biosensors, implants, catheters, and systems for drug delivery) would benefit from an effective control over molecular and cellular interactions at material surfaces. Main challenges in this field include the control of biomolecules (e.g., proteins, DNA) adsorption on different surfaces. Designing surfaces that allow proteins to be adsorbed in a controlled manner is particularly important and challenging. Many strategies were recently developed to spatially or temporally control protein adsorption.
In this project, a novel strategy for selective protein adsorption from a mixture of proteins will be developed. This strategy will be based on the use of mixed polymer brushes sensitive to ionic strength and pH of the surrounding medium. The project rests on the following steps:
i.	The design of mixed polymer brushes whose properties will be tuned by adjusting pH and ionic strength of the medium. The influence of polymer properties (molecular weight, and degree of dissociation and conformation through pH and ionic strength variations) on protein adsorption will be studied.
ii.	The development of a procedure, based on time-of-flight secondary ion mass spectrometry (ToF-SIMS), to distinguish different proteins adsorbed together on model interfaces.
iii.	The use of this ToF-SIMS-based procedure to investigate the potential of the created mixed brushes to selectively adsorb one protein, at first from a mixture of two or three proteins, and then from a more complex medium.
The results obtained in this work will be significant for material science and biomedical applications through the development of a robust procedure to prepare “smart” surfaces with novel properties to control protein adsorption.
How to grow a flat leaf?

Growing flat leaves is crucial for plant success, since it directly affects light interception and photosynthesis. This process is tightly regulated by endogenous signals revealing a strongly genetically defined developmental program, but is also modulated by the light environment. As shown using null mutants, both blue light receptors phototropins (phot) and red/far-red light receptor phytochromeB (phyB) affect leaf flattening, and it was recently found that plants lacking PKS3, a protein involved in phot signaling, suffer severe flattening defects. The main objective of this project is thus to determine how light signals interact with endogenous cues to control development of a flat leaf. First, I will perform an exhaustive temporal and spatial characterization of the phot and phyB-mediated light control of leaf development applying various light treatments and complementing phot1phot2, phyB and pks3 with tissue-specific promoters. Next, I will apply the latest microscopy techniques to determine the expression pattern of leaf development markers under various light conditions and in photoreceptor mutant backgrounds. Also, given the major role of auxin in leaf development, and the various ways in which phot and phyB control it, I will study auxin abundance, transport and sensitivity at the tissue and cellular level. Finally, I expect to identify new components of phot signaling evaluating the interactome of PKS3 through IP-MS. Thereby I expect to determine how a conserved developmental program and photosensory cues crosstalk to control leaf flattening.
Intrinsically dynamic covalent polymers

Aiming at enabling covalent polymers with intrinsically dynamic abilities, this proposal will focus on the dynamic chemistry of poly(1,2-dithiolanes) to explore their fundamentals and applications. The motivation of the research will rest on uncovering several fundamental questions and principles for the design of poly(1,2-dithiolane), including i) exploring the space of structure-property relationship, ii) realizing precision polymerization by supramolecular confinement, and iii) creating dynamic matter with biomimetic architectures and functions. The research approaches and strategies have been demonstrated in this proposal with detailed backgrounds, methods, and mechanisms. The two ways of knowledge will be launched by this action because of the favorable complementarity of the researcher and the host. The researcher bears a strong background of supramolecular chemistry and polymer chemistry, which is recognized by many renowned international awards and fellowships. The host lab is renowned for stereochemistry, photochemistry, and organic chemistry, which has built a great experimental platform as well as scientific prestige, including the winning of Nobel Prize for chemistry. This proposal also formulates a series of actions and plans to enhance the future career prospect of the researcher after the fellowship. The aspects of exploitation, dissemination, and communication are also involved in this proposal. Detailed work plans with effectiveness and training diversities are formulated, ensuring the action of this proposal with good balance among research, personal training, and career development. The project risks are reasonably evaluated and analyzed with sufficient protection of contingency plan. The high coherence and continuity of the proposed projects enable this proposal to be completed in the period of this action.
A preliminary survey of the histopathological features of skin from the planum nasale and adjacent skin of dogs unaffected by dermatological or respiratory disease

There is a general belief that immune system cells are present in larger numbers in the planum nasale and adjacent haired skin than in other locations in the dog. However, little published information about the normal histological appearance of the skin of this area exists.The aim was to obtain information about the normal histological appearance of canine skin for specific anatomical regions of the planum nasale and the haired skin adjacent to the planum nasale.Samples from three sites were obtained from the planum nasale and adjacent haired skin of 25 dogs of varying age, breed and sex, with no evidence of dermatological or respiratory disease.Samples were analysed to determine and quantify the immune system cells present in the samples. Slides were stained with haematoxylin and eosin or toluidine blue; immunohistochemical stains for CD3 and CD79a were applied.Immune system cells, including lymphocytes and plasma cells, were either very rare or present in low numbers. The majority of lymphocytes were of T-cell origin, with only infrequent B cells identified. Samples contained numerous melanophages, consistent with pigmentary incontinence, regardless of the presence or absence of inflammatory cells. Mast cells and plasma cells were present in low numbers.Inflammatory change noted in diagnostic biopsies from this area from dogs with clinical disease is likely to be of pathological significance. However, pigmentary incontinence appears to be common at this site in clinically normal dogs without significant inflammatory cell infiltration and is therefore not necessarily of pathological significance when seen in isolation in this location.
Geschäftsidee Kommerzialisierung Support-Service: Verkauf über das Internet, Cendra sp. z o.o.

Ziel des Projekts ist es, das Potenzial, die Wettbewerbsfähigkeit und die Effizienz von Cendra sp. z o.o. durch den Kauf einer entwicklungsfördernden Beratungsleistung zu steigern, die auf die individuellen Bedürfnisse des Unternehmens zugeschnitten ist. Der Service besteht in der Überprüfung des Potenzials und der Bedürfnisse von Cendra sp. z o.o. in Bezug auf die Möglichkeiten und Bedürfnisse der Implementierung eines neuen Produkts/eines neuen Dienstes, in den vom Unternehmen angenommenen Grundsätzen des Betriebs und der Beziehungen zur Umwelt. Das für die Implementierung geplante Produkt wird ein auf einem Online-Shop basierendes Vertriebssystem sein, das sich an Fachleute aus ganz Polen, der Europäischen Union und insbesondere an Unternehmen aus Podlasie richtet. Das festgestellte Marktproblem, das durch das neu geschaffene Produkt angegangen werden soll, ist das Fehlen der Möglichkeit eines schnellen Verkaufs von Dienstleistungen und Produkten, die von Cendra sp. z o.o. über das Internet angeboten werden. In der aktuellen Entwicklungsphase fehlt Cendra sp. z o.o. spezialisiertes Personal, das das Marktpotenzial für den Ausbau des bestehenden Vertriebssystems mit einem neuen Kanal auf der Grundlage eines spezialisierten Online-Shops bewerten kann. Derzeit sind die Idee selbst und die Möglichkeit ihrer Umsetzung im Jahr 2021 zu überprüfen. Die Indikatoren für die Durchführung der einzelnen Arbeitsschritte können Teilberichte sein. Die Beendigung des Dienstes besteht in der Bereitstellung einer Zusammenfassung des gesamten Dienstes. Während der Erbringung der Dienstleistung ist die Einbeziehung des Unternehmers und des Dienstleisters in den Prozess der Erbringung der Werbeleistung geplant. Die erworbenen Kompetenzen der Umsetzung des Dienstes und die praktische Erfahrung ermöglichen es, den Horizont des Bewusstseins, der Entwicklung der eigenen Mitarbeiter und der Überprüfung der aktuellen Vision der Unternehmensentwicklung zu erweitern. Das direkte Ergebnis ist die Schaffung eines neuen Produktes und in Zukunft wahrscheinlich ein neuer Geschäftszweig des Unternehmens. Das Projekt steht voll und ganz im Einklang mit den Zielen des RPOWP, der EU und der Mitgliedstaaten.
A.A.A. - CERCAN S-I 

In the territory of the Pozzuolo del Friuli municipality lies one of the largest and most important neolithic settlements in Northern Italy: the excavations - which have been carried out for more than fifteen years in the location of Sammardenchia - have brought to life hundreds of archaeological structures and recovered thousands of pieces of pottery, objects in polished stone and chipped flintstone. The Sammardenchia material highlights the contribution made to this process by the neolithic communities in Slovenia and Croatia. In this Friuli site, several pieces of pottery deriving from the eastern Dànilo culture have been found, together with statuettes and religious vases: this material proves the existence of a wide common cultural heritage in the whole Upper-Adriatic area at the beginning of the Neolithic period. In addition to archaeological research, other initiatives have been carried out in recent years at Pozzuolo; held in cooperation with local associations, these actions concern the local populations and schools and aim at enhancing the mentioned heritage and at experimenting educational activities. They include guided tours of the excavations, conferences, showing of films, experimental archaeology days, educational workshops. A documentation centre on the archaeology of the territory has also begun its work, which includes various educational activities taking place during the year. In this framework, the project aims at developing cooperation between the Italian archaeologists who work at the Sammardenchia site and the Slovenian ones who have studied the Sermin site (Koper-Capodistria), since the two sites are very similar. The aim is to identify the common cultural roots which, during the Neolithic period, linked Italy and Slovenia, together with the flows and exchanges of raw materials that took place in that age between the two regions.