SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Abstract 2293: ZEB1 and ZEB2 promote EMT and invasion in esophageal squamous cell carcinoma

Abstract Introduction: Epithelial-mesenchymal transition (EMT) promotes tumor invasion and metastasis. Amongst transcription factors essential in EMT, zinc finger E-box binding proteins ZEB1 and ZEB2 (ZEB) are upregulated in several tumor types due to loss of the miR-200 family. However, the role of ZEB in esophageal squamous cell carcinoma (ESCC) remains to be elucidated. Methods: ESCC cell lines were grown. Immortalized human esophageal cells EPC2-hTERT were retrovirally co-transduced with EGFR and mutant p53 (p53R175H), early genetic lesions common in ESCC, leading to transformation as described previously (Genes Dev. 2007; 21:2788). Short hairpin RNA was expressed by lentivirus to knockdown ZEB1 and ZEB2. Epithelial cells were grown in organotypic 3-D culture, a form of tissue engineering. Laser capture microdissection (LCM) was performed to isolate RNA for gene expression profiling in the invasive cells in 3-D culture as well as microRNA determination in archived paraffin embedded primary ESCC tissue samples. Real-time RT-PCR, Western blotting and immunohistochemistry were done to determine gene expression. Senescence-associated β-galactosidase activity was determined. Results: In primary ESCC, ZEB expression was found upregulated in tumor cells at the invasive front with increased Vimentin and decreased E-cadherin expressions. Moreover, LCM documented a significant downregulation of the miR-200 family in the invasive tumor cells consistent with EMT. ZEB upregulation and concomitant loss of the miR-200 family were also found in two out of 11 ESCC cell lines, exhibiting EMT corroborated by spindle-shaped cell morphology as well as an E-cadherin to N-cadherin class switch. EGFR overexpression and p53 mutation in EPC2-hTERT cells resulted in ZEB upregulation and a significantly augmented susceptibility to EMT, where robust induction of ZEB and suppression of the miR-200 family were observed upon TGF-β treatment. In 3-D culture, the cells co-transduced with EGFR and mutant p53 markedly invaded into the underlying stroma compartment. The invasive cells had a gene signature compatible with EMT along with ZEB upregulation. Finally, knockdown of either ZEB1 or ZEB2 not only prevented TGF-β from inducing EMT, but also TGF-β-mediated massive senescence in EPC2-hTERT cells transformed by EGFR and mutant p53. Conclusions: Our data indicate that ZEB1 and ZEB2 are negatively regulated by the miR-200 family and induced upon invasion in ESCC. ZEB may regulate senescence and EMT in concert with TGF-β signaling, thus contributing to esophageal carcinogenesis and tumor progression. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 2293.
Dinoflagellates and Raphidophytes as Feedstock for Biofuel Production

This book is based in the knowledge acquired by the Dr. Fuentes-Grunewald, who have more than 20 years of experience in microalgae identification, isolation and biomass production. The main objective is to give relevant information of how to produce microalgal biomass specifically from Dinoflagellates and Raphidophytes microalgal groups, taking into account specially in those potential environmental impacts. Currently Dr. Fuentes-Grunewald is focused in the production of specific metabolites generated by different microalgae. These metabolites are susceptible to be exploited in an industrial scale in order to produce advanced bio-products for different applications in industries such as bio-medicine, cosmetic, nutraceutical, animal feed, among others. I hope that this book help to have a better and environmentally friendly world.
Making digital transformation a reality for insurers

Last time you paid your insurance bill, did you realize that about 25% was to pay for legacy processes that are frozen due to inflexible IT systems setup in the 80s and 90s? You’d be right to expect that a worldwide industry with 32,000 insurers generating over 3% of world’s GDP with a highly immaterial business model would be the first to make effective use of IT. It isn’t. 
The knowledge needed to run the business has been buried under layers of dated tools, unable to respond to new customer segments or expectations, and leading traditional insurers to the verge of disruption in the next 5 years. One of the main causes is insurers take on average 9 months to launch a new insurance product due to the complexity and number of their legacy systems. As a consequence, they spend 70% of their IT budget just to maintain the status quo. 
With InsurAgility, using an insurance product editor and generative code, we enable insurers to launch new products in one month, make complex changes in hours and simple ones in minutes. All done by actuaries and insurance business users with no need for IT staff. The result? 90% faster time to market, anticipating sales and lowering operating costs. 
Why would conservative insurers take such a disruptive approach now? Three reasons: rise of the empowered customer, new nimble players that are responding fast to these customers for a fraction of the price, and the lowest interest rates in recorded history. There is no choice but to act on the operational costs that add no value for customers. With 30+ years of experience in insurance, 50+ customers and 5 world-class partners supporting the sale and implementation of our software, i2S proposes to further develop its disruptive solution to target an addressable market of 1,900 insurers. In 3 years, with just 2% of the addressable market, i2S will achieve a ROI of 3 and 10M€ in accumulated profits.
Application of Multicriteria Decision Analysis with A Priori Knowledge to Identify Optimal Nonpoint Source Pollution Control Plans

AbstractControl of agricultural nonpoint sources of pollution is achievable through implementation of conservation practices at the farm or field level. There are several approaches to achieve a targeted implementation of conservation practices at the watershed scale. Recent studies have shown that optimization methods hold great promise for optimal allocation of nonpoint source pollution control measures. However, the use of optimization is a computationally intensive task and ultimately depends upon availability of automated optimization tools and expertise to analyze the results. In this study, a novel multicriteria decision analysis (MCDA) framework is proposed to identify a near-optimal suite of conservation practices at the watershed scale using a priori knowledge about the system. The proposed framework requires: (1) selecting a set of criteria, depending upon the objectives of the study, that should be considered in ranking the alternatives; (2) constructing an evaluation matrix; and (3) using a c...
Gender equality actions in research institutions to transform gender roles

Devising and implementing GEPs in higher education institutions or research centers is a formal requirement to enhance actions that favor real and effective equality between women and men. While this is a reality, its effectiveness is bound to a series of factors, like the suitability of the agents involved in its setting-up, the strategic alliances built, and the awareness raised on the potential resistances –both tangible and intangible- that are to be faced in its implementation and prevent real structural changes in these organisations. Every GEP should be understood as a process that is born out of the will to grow and become stronger so that equality between women and men can be promoted and legitimised. One way to maximize the effectiveness and efficiency of a GEP is to collect and incorporate the expertise, knowledge and experience of previous projects. For this reason, our project aims to implement 6 equality plans in 6 organizations (5 Universities and 1 Research Funding Organization) applying the criteria established and tested by GEAR-tools. The goal is to advance in the application and evaluation of equality measures in universities with the support of non-university entities that favor their promotion, impulse, evaluation and development. The GEPs will pursue the recognition and promotion of the research career of women, the incorporation of women in decision-making positions, and the promotion of a culture of equality in organizations. To this end, the focus will be on the deconstruction of sexual roles in order to unveil often unconscious gender biases that operate in processes of decision-making, selection and promotion of people and in the attribution of value and recognition.
Electric losses balancing through  integrated  storage and power electronics towards increased synergy between railways and electricity distribution networks

European distribution networks and light-railway networks present common issues: both have been developed as independent networks, relying on the resilience and robustness of existing power supplies. However, RES progressive penetration introduced an increasing degree of uncertainty on the direction of power flows. Both networks are looking at integrated solutions targeting: i) reduction of electricity losses ii) increase the grid stability in a high local RES penetration scenario iii) accommodate the needs of new energy actors such as EVs, electrical storages and prosumers. Electrified transport networks such as light railways could act to enhance distribution grid stability providing ancillary services inter-exchanging electricity. However such potential is still unexploited. E-LOBSTER intends to capture such potential through the development of an innovative, economically viable and easily replicable electric Transport-Grid Inter-Connection System that will be able to establish synergies between power distribution networks, electrified transport networks (metro, trams, light railways etc.) and charging stations for EVs. The proposed solution encompasses the integration of high power flow Electric Storage with smart Soft Open Points providing flexible control. The system will be managed by an integrated Railway + Grid Management System which starting from the real time analysis of energy losses will be able to optimize the interexchange of electricity between the networks maximizing local RES self-consumption. The hardware and software control platform will be demonstrated at TRL 6 in one substation owned by Metro de Madrid. Business models and standardisation needs will be deeply analyzed and measures to unlock existing barriers will be promoted and in parallel the knowledge generated from the project will be further exploited for the definition of the up-scale design of a full scale E-LOBSTER system, paving the ground towards replication across the EU.
Effect of radial asymmetry of magnets in surface-mounted permanent magnet motors on cogging torque

During the mass production of surface-mounted permanent magnet motors the rotor and stator geometrical dimensions usually deviate from their nominal values due to manufacturing tolerances which impact machine performance. One such common tolerance can be noticed in the placement of the permanent magnets on the rotor surface which creates new orders of cogging torque. Finite element models can be used to analyze the cogging generated due to the asymmetry in the magnet placement. However, it is time consuming to study the effect of imbalance of each magnet numerically since periodicity and symmetry conditions cannot be used to reduce the model. Therefore, in this paper an analytical model is presented to study the effect of such imbalance on the cogging torque. The model is validated against a finite element model and also with experimental results.
A HIGH HEAD SOLAR POWERED FLUID PUMP WITH LOW DISCHARGE

The embodiments of the present invention provide a system and method for operating a solar powered high-head low-discharge pump without impeller for non-centrifugally transporting the fluid. The system has a pump enclosed in a water-proof floatation device that floats at the surface of the fluid. The center of gravity of the system is arranged just below the surface of the liquid. When the fluid in a tank reaches a threshold value, the system automatically activates the pump and transports fluid from the sump to the tank the system has a solar panel, a low power high head low discharge pump, a control device, and a plurality of liquid level sensors. The plurality of liquid level sensors is configured to detect a liquid level in a sump and in a tank.
Drive arrangement for a tap changer

A drive arrangement for a tap changer includes a first movable latch having a first and a second end a first rotatable wheel with a first actuating element, a second rotatable wheel with a first locking element, and a first spring connected between the first and second wheels. The first actuating element is provided on a first half of a first curved surface of the first wheel, the first locking element is provided on a first half of a second curved surface of the second wheel, a second actuating element is provided on a second half of the first curved surface aligned with a first end of a second latch and a second locking element of the second rotating wheel is provided on a second half of the second curved surface aligned with a second end of the second latch.
Predicting comorbid cardiovascular disease in individuals with mental disorder by decoding disease mechanisms

Comorbid cardiovascular disease in people with severe mental disorders is a major public health concern and poses a considerable financial burden on European Health Care. The CoMorMent project will uncover mechanisms underlying the higher incidence of cardiovascular disease in people with mental disorders. This project builds on our recent findings that genetic variation that affects genes expressed in the brain and which increase the risk of mental disorders also impact lifestyle and behaviour (e.g. diet, exercise, and smoking) that increase cardiovascular risk. The project will identify molecular mechanisms common to mental disorders and unhealthy lifestyles that increase the risk of cardiovascular disease. We will take advantage of our genotyped biobank samples united with large national registries with information about disease trajectories and comorbidity in over 1.8 million people. The “big data” available to CoMorMent means that we can apply new statistical tools to discover novel sequence variants conferring risk of both mental disorders and cardiovascular diseases and determine how these may be mediated by lifestyle or behaviour. We will characterize the underlying mechanisms by identifying accompanying structural brain changes and body fat composition from MRI data in combination with gene expression and functional studies. The CoMorMent multidisciplinary expert team in clinical science (cardiology, psychiatry), genetic epidemiology, molecular genetics, and neuroscience combined with experts in machine learning and computation will generate findings that will form the basis of novel stratification and prediction tools, which will be tested and validated in clinical samples. Thus, CoMorMent will form the basis for a new approach in clinical studies by providing precision medicine tools for clinical implementation to remediate a major public health issue.
[Hysteroscopy to relieve IUD-related symptoms].

A levonorgestrel-releasing intrauterine device (LNG-IUD) had been placed in 4 patients, aged 33, 27, 46 and 27 years. They subsequently experienced symptoms that were possibly related to the IUD, such as haemorrhagic discharge, pain and dyspareunia. Patients who have persistent symptoms after IUD placement need to be examined. If a malpositioned IUD is suspected, outpatient vaginoscopic hysteroscopy should be considered. Hysteroscopy can reveal the cause of the symptoms. Furthermore, an IUD that is incorrectly positioned can be repositioned during the same procedure. One advantage to this is that unnecessary removal of an IUD may be prevented. The first patient referred to in this article had lost confidence in the IUD and requested its removal. In the second patient, the IUD had perforated the anterior wall of the uterus and it was removed as well. In the third patient, the IUD had perforated the posterior wall of the uterus, but it was repositioned during the hysteroscopy. In the last patient, hysteroscopy showed the IUD to be in a transverse position, but this could be corrected immediately.
Phase Imaging of Proton Exchange Membranes under Attractive and Repulsive Tip−Sample Interaction Forces

The nature of tip-sample interaction forces in atomic force microscopy (AFM) phase imaging strongly affects the resolution of proton conducting domains mapped at the surface of Nafion membranes. Images acquired in repulsive mode overestimated the area of individual proton conducting domains by a factor of 4 (360 vs 90 nm(2)) and underestimated the number of these domains by a factor of 3 (0.9 domains per 1000 nm(2) vs 2.7 domains per 1000 nm(2)) compared to attractive mode. When the cantilever was driven above resonance or when the combination of scan parameters resulted in an AFM feedback loop that was not fully optimized, phase contrast arose not from proton conducting domains but instead from changes in topography. In attractive mode, phase contrast did not correlate with either topography or changes in topography, and the resulting images most accurately represent the fluorocarbon and aqueous domains at the surface of Nafion membranes.
Key account management process in eic pilot activities (accelerator, fti/fet-open projects) and enhancing the innovation management capacities of smes (kamino-3)

The project aims at boosting the participation of European SMEs in the largest research and innovation funding programme of the EU, H 2020, especially in the EIC pilot activities (Accelerator, FTI/ FET open projects) and as a second at enhancing the innovation management capacities of high innovative SMEs. Furthermore, new SME relevant challenges of the HORIZON Europe Programme (2021-27) will be taken into consideration.
Implementation activities are organized in two work packages (WP):
Within WP1 Key Account Management (KAM), the project will accompany beneficiaries of the EIC pilot activities (Accelerator, FTI/FET-open projects) in the implementation of their project activities and to initiate a coaching for them. 
In WP 2 Enhancing Innovation Management Capacity process (EIMC), the project activities should result in significant higher innovation management capacities of SMEs. Therefore, the innovation capacities and processes, innovation strategies and internal organizations as well as their relations with innovation partners will have to be assessed. For this, the partners will apply proven assessment tools. Identified gaps and bottlenecks in the innovation management capacities will be discussed and measures and action plans to overcome them will be defined by the EEN consultants jointly with the SME. 

KAMINO-3 contains an assistance package for successful applicants in EIC pilot activities (Accelerator, FTI/FET-open projects) of H2020 and delivers assessments, advice and consultations to support SME to strengthen their innovation management capacities. Three EEN partners –ATI Kueste GmbH, Steinbeis-Forschungszentrum and Technologiepark Warnemünde GmbH – work on the mentioned activities. The IHK zu Rostock– will formally act as coordinator but will not implement any tasks. 
Potential candidates will be acquired by various sources. For the KAM-process they will be nominated by the European Commission through a special evaluation process. The consortium EEN M-V plans to perform 15 assessment service packages, both KAM and EIMC, in 2020-21.
Relative Importance of External Quality Attributes of Shell Eggs: A Consumer Preference Approach

Three Focus Group Discussions (FGD) and questionnaires (n= 120) from two sensory evaluation sessions were used to identify, rank and compare external quality attributes of shell eggs for their relative importance. Data collected were described and analysed inferentially. The identified attributes were also matched to consumer quality expectations. Quality attributes identified in order of importance were size, cleanliness, colour, uniformity and texture with respective scores of 56, 47, 24, 14 and 8. An inferential comparison of the attributes however, showed that size and cleanliness were rated higher (P 0.05) sub-class differences. Respondents expected large eggs to have more edible material; clean shells to signify freshness and safety, while dark coloured eggs were expected to be more nutritious and to have stronger shells. It is suggested that these attributes could form a basis for the development of a grading system in Nigeria. Also egg retailers could gain some competitive advantage by paying attention to the attributes identified, especially those of higher relative importance like large size and shell cleanliness.
Low Accuracy of FIB-4 and NAFLD Fibrosis Scores for Screening for Liver Fibrosis in the Population

Fibrosis-4 (FIB-4) and the nonalcoholic fatty liver disease fibrosis score (NFS) are the 2 most popular noninvasive blood-based serum tests proposed for widespread fibrosis screening. We therefore aimed to describe the accuracy of FIB-4 and NFS to detect elevated liver stiffness as an indicator of hepatic fibrosis in low-prevalence populations.This study included a total of 5129 patients with concomitant measurement of FIB-4, NFS, and liver stiffness measurement (LSM) by Fibroscan (Echosens, France) from 5 independent population-based cohorts from Spain, Hong Kong, Denmark, England, and France; 3979 participants from the general population and 1150 from at-risk cohorts due to alcohol, diabetes, or obesity. We correlated LSM with FIB-4 and NFS, and calculated pre- and post-test predictive values of FIB-4 and NFS to detect elevated LSM at 8 kPa and 12 kPa cutoffs. The mean age was 53 ± 12 years, the mean body mass index was 27 ± 5 kg/m2, and 2439 (57%) were women. One in 10 patients (552; 11%) had liver stiffness ≥8 kPa, but 239 of those (43%) had a normal FIB-4, and 171 (31%) had normal NFS. The proportion of false-negatives was higher in at-risk patients than the general population. FIB-4 was false-negative in 11% of diabetic subjects, compared with 2.5% false-negatives with NFS. Waist circumference outperformed FIB-4 and NFS for detecting LSM ≥8 kPa in the general population. Almost one-third (28%-29%) of elevated FIB-4/NFS were false-positive in both the general population and at-risk cohorts.FIB-4 and NFS are suboptimal for screening purposes due to a high risk of overdiagnosis and a non-negligible percentage of false-negatives, especially in patients with risk factors for chronic liver disease. Waist circumference emerged as a potential first step to identify patients at risk for liver fibrosis in the general population.