SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Ai enabled managemement of patients at risk of diabetic foot ulcer

Diabetic foot ulcers (DFU) lead to approximately 150,000 amputations and €23 billion in costs in Europe each year. Of the
60 million diabetics in Europe , 1.5 million currently have a diabetic foot ulcer and 15 million will develop on at some point in
their life . Each ulcer takes 3-6 months to heal and costs upwards of €14,000 to treat, however, if hospitalisation or
amputation is required these costs can be as high as €100,000 . Diabetic foot ulcers pose a significant burden on healthcare
systems around the world. The NHS in England spends almost 1% of its entire annual budget (£1.13 billion) on the diabetic
foot. Almost all of these ulcers and amputations are preventable through early identification and proper care. Bluedrop
Medical are developing a remote monitoring system that uses computer vision and machine learning to predict and prevent
diabetic foot ulcers (DFUs). The home-based device, taking the form of a bathroom scales, performs a daily scan of the
patient’s feet. In 10 seconds, thermal and photographic data is collected and sent to the cloud. Advanced algorithms monitor
daily foot scans to detect DFUs before they develop, providing actionable alerts to both patient and healthcare provider. The
technique of temperature monitoring has been proven to prevent 70% of DFUs and Bluedrop Medical are building this
technique into an easy and quick to use device enabled by advanced sensor technology, computer vision algorithms and
machine learning. By preventing ulcers, the technology can prevent hundreds of thousands of amputations, improving lives
and saving healthcare systems millions of euro each year. Bluedrop Medical is targeting the highest risk patients who
currently have a 30-40% annual incidence of ulceration by preventing ulcers in this group a potential average saving of
€3,000 per patient can be achieve
Imidacloprid induced alterations in enzyme activities and energy reserves of the land snail, Helix aspersa

The in vivo sublethal toxic effects (0.2 and 0.6 LD50) of topically applied imidacloprid on biochemical biomarkers in the land snail, Helix aspersa was examined. Biochemical perturbations were assessed by measuring the three enzymatic (Acetylcholinesterase, AChE; catalase, CAT and glutathione-S-transferase, GST) activities and three energy reserves (protein, glycogen and lipids) in the snails. Snail samples were taken from each sublethal dose and control groups at 1, 3 and 7 days after treatment. The results revealed that there were overall decrease in AChE activity as well as depletion of lipids and glycogen contents in the imidacloprid-treated snails compared to control groups. The CAT and GST activities of treated snails with the sublethal doses of imidacloprid were significantly higher than those of untreated controls along the three times of exposure. Moreover, an increase in the level of total proteins was observed in animals treated with 0.6 LD50 imidacloprid compared to control groups. The alterations in all tested biochemical perturbations were most pronounced with the 0.6 LD50 than 0.2 LD50. This study suggests that alterations of the enzyme activities and energy reserves in this species that could be useful as biomarkers of imidacloprid exposure in the evaluation of terrestrial impacts of this insecticide.
#Com.Viso

#Com.Viso project would like to develop a strategy based on development of communities to ameliorate life quality of populations living in remoted mountain territories around Monviso. Concerned population are especially young, elders, and peoples with difficulties on the territory. 
Indeed, it emerge that social conditions, of elders and young, are more difficult in mountain areas. Moreover, the lack of own mean of transport, or the impossibility to use this last one, the depopulation of mountain territories in ALCOTRA’s territories creates an important reduction of meeting and exchanges moments, which generates, a social isolation of some groups of peoples. 
To fight this phenomenon, #Com.Viso project purpose to innovate in the sanitarian and social services sector to promote the development of communities, putting social animation at the hearth of their action, as instrument to reboot social groups dynamism.
The figure of social animator is central for the project because it puts at the disposition of populations, in an isolation situation, new instruments allowing their interconnections. But the place of the social animator go further, becoming a mediator between different communities allowing them to create a link between administrations and the territory in order to promote various local actions developed before. 
The profile diversity of partners allows to develop a global comprehension of integration modalities thanks to various socio-sanitarian services represented. 
The final objective of the project will be to diffuse a model of socio-sanitarian innovation, efficient, sustainable and applicable to the whole cross-border territory, but also to launch new pilot experiences of a new territorial animation approach.
A Review of Privacy Preservation Technique

Privacy-preserving is one of the most important challenges in a computer world, because of the huge amount of sensitive information on the internet. The paper contains several privacy preservation techniques for data publishing in the real world. There are several privacy attacks are associate but among of them mainly two attacks are record linkage and attribute linkage. Many scientists have proposed methods to preserve the privacy of data publishing such as K-anonymity, l-diversity, t-closeness. K-anonymity can prevent the record linkage but unable to protect attribute linkage. l-diversity technique overcomes the drawback of k-anonymity technique but it fail to protect from membership discloser attack. Tcloseness technique prevents to attribute discloser attack but it fail in identity disclosure attack. Its computational complexity is large. In this paper we present the novel technique call slicing which to be implemented with various data set through prevent the privacy preservation for data publishing. The goals of this paper is re-analysis a number of privacy preservation of data mining technique clearly and then study the advantages and disadvantages of this technique.
Do people who load their feet differently need insoles that have different stiffness?

Background: Plantar pressure reduction is an important aspect of diabetic foot management. However little information exists about the optimum cushioning properties of materials used in diabetic footwear as insoles/foot-beds. Numerical analyses have indicated that optimizing the material properties of footwear materials can improve their ability to reduce pressure.

Aim: To investigate if the optimal insole stiffness would vary based on patients’ body mass (BM) in people with diabetic neuropathy.

Method: Custom PU foams were produced using different ratios of chemical components to achieve a range of different stiffness. Uniform thickness (400 mm × 400 mm × 10 mm) foam sheets were produced with shore-A hardness between 3 and 45 and average(±stdev) increments of 5(±3). Standardized compression tests were performed for all 10 custom materials as well as for 3 commercially available foam materials used in diabetic footwear. Plantar pressure was measured during balanced standing on all custom material sheets for 4 diabetic neuropathic volunteers: 2 with BM of 49 kg ± 1 kg and 2 with BM of 73 kg ± 2 kg.

Results: The maximum compressive force for 50% compression of the commercially available foams was similar to custom foams with 11–28 shore-A hardness. Peak plantar pressure was minimised for materials with shore-A hardness 6 and 11 in subjects with BM of 49 kg ± 1 kg and 73 kg ± 2 kg respectively. In all cases using softer or stiffer material (by 1 shore hardness increment) increased pressure by 24% ± 26% and 32% ± 34% respectively.

Conclusions: Careful selection of insole/foot-bed stiffness can improve the pressure reduction capacity of diabetic footwear. Optimum material stiffness increased with the BM of the volunteers.
Challenges of using an AUV to find and map hydrothermal vent sites in deep and rugged terrains

In March 2010, the Autosub6000 AUV embarked on a cruise to discover, locate and map hydrothermal vent sites in an active spreading centre, the Cayman trough in the Caribbean sea. The environment provided the challenge of steep and rugged terrain together with deep water (in places greater than 5000 m). Autosub6000 is a flight class, hydrodynamically shaped AUV, with good endurance capability, making it well suited for searching for plume signals and mapping terrain over the required moderately large areas. However, it must fly at a forward speed greater than 0.8 ms- <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1</sup> to achieve control, and so it requires a capable forward look collision avoid capability. Another potential challenge is navigation. To make best use of ship time, AutosubSOOO missions are commonly conducted with neither the support ship in attendance, nor an acoustic transponder long baseline network. Hence positioning is dependent upon the AUV autonomous navigation (aided by a position fix after the AUV's descent to within ADCP bottom tracking range of the seabed). For the cruise on the UK research ship RRS James Cook, the AUV was equipped with sensors for EH (redox potential), turbidity, CTD, tri axis magnetometer, and an EM2000 multibeam sonar. The paper describes the Autosub6000 vehicle, its systems, capabilities, the missions it undertook in the deep Caribbean sea, and the discoveries it made. The missions, although ultimately very successful, were not without problems, with, for example, the steep seabed slopes, at times affecting the accuracy for the navigation system. The paper will also discuss these issues and how they might be addressed in the future.
New plays in the p53 theater

The p53 tumor suppressor and its paralogs p63 and p73 are at the crux of a network modulating cellular responses against potentially tumorigenic events. p53 acts primarily as a transcription factor, regulating the expression of both coding and non-coding RNAs, as well as the activity of RNA processing complexes. In line with their anti-tumorigenic function, p53 and p63 have recently been implicated in restricting tumor cell invasion. In parallel, a growing number of non-canonical target genes have been added to the p53 repertoire. These include genes encoding for proteins that impinge on a broad spectrum of cellular functions, from cell metabolism to stem cell renewal. The p53 story is still far from being fully told.
Network Security: Android Intrusion Attack on an Arduino Network IDS

The objective of this paper is to present an open source free standalone Network IDS achieved by an ARDUINO YUN board and study its effectiveness. To do this we develop a Python IDS using raw sockets and then we embark it on our board. To assess our IDS response time, we develop an Arduino simulator for intrusion attack. Using this simulator we carry out several attacks and we note the different detection times. To evaluate these detection times we conduct using the same simulator attacks on the same network and in the same conditions but using a software IDS developed with Visual C ++ using the PCAP library. The detection times of the software IDS are compared with those of the standalone IDS. We note that the standalone IDS response times are better than the software IDS
A Bioética global e os direitos humanos para o desenvolvimento sustentável

Tomar decisões criticamente fundamentadas entre o que podemos fazer e o que devemos evitar, ou o que é melhor fazer quando surgem alguns dilemas, é crucial para o discernimento ético e político. A legitimidade das decisões humanas sobre as aplicações da ciência e da tecnologia para promover a vida, a saúde e o bem-estar dos povos é possível graças à cooperação internacional e à protecção do direito como instrumento de protecção e garantia do bem comum, da dignidade e bens fundamentais da pessoa, isto é, o que chamamos de direitos humanos. A Bioética Global propõe uma articulação adequada entre as questões bioéticas e os direitos humanos como paradigma ético universal que deve ser levado em consideração nas decisões, públicas e privadas, no campo das ciências da vida e da saúde. O desafio ético e político é saber como equilibrar o interesse legítimo da indústria por lucros e o desenvolvimento econômico com inovação científica e tecnológica prudente e para o bem das pessoas e comunidades. O reconhecimento mútuo está na base da relação que nos permite dar a cada um o que é seu e promover a convivência pacífica na nossa casa comum. Se realizada de acordo com os imperativos morais de solidariedade e justiça, atentando para a minimização das distâncias entre pobres e ricos e entre as regiões Norte e Sul Global, a ciência e a tecnologia contribuirão para o desenvolvimento humano de forma eficaz e eticamente sustentável.Palavras-chave: Bioética; Direitos Humanos; Desenvolvimento Sustentável
Highway Capacity Prediction in Adverse Weather

The purpose of this study was to find out the effects of rainfall on traffic flow rates and the implications on highway capacities. Data was generated from a pneumatic tube detector placed on a 2 km straight section of a principal road that was operating in the free flow regime. This is with a view to isolating all bottlenecks and incidences that could affect traffic flows and to see the direct effect of the rainfall on traffic. Data from nearby rain gauge station was used to identify dry and wet traffic flow conditions. Empirical evidence exists for traffic flow contraction, speed reduction and increase in density. A speed reduction of 3.52% resulted in a flow rate change of 8.64% under rainfall conditions. Furthermore, the fundamental diagram was used to predict the capacity flows in both dry and wet conditions. A 42.27% loss of capacity was obtained at critical densities of 186.82 and 111.97 vehs km -1 for both dry and wet conditions respectively. It is concluded that adverse weather can seriously degrade the capacities of highways. At higher flow rates, the instabilities that could result from adverse weather effects can cause prolong delays to drivers with its attendant economic losses. Rainfall intensity variation should be investigated to determine capacity loss thresholds at which resources can be placed to manage traffic in adverse weather.
REVITALISING AND PROMOTING TRADITIONAL MARKETS IN CENTRAL EUROPE

A majority of traditional markets are nowadays experiencing a serious decline, thus threatening a tradition that stretches back to medieval times and in some cases even beyond. Markets have indeed been the backbone of many towns and city centres as well as the oldest form of commercial exchange. They still can play an important role in the regeneration of city centres and promoting 'greener' lifestyles among citizens.

The basic idea of the project CENTRAL MARKETS is to help re-discovering the attractiveness of markets in eight target cities/regions by developing new and innovative market revitalisation strategies in order to reinforce and balance the relationship between city/regions and markets.
PRESSURE RELIEF VALVE AND METHOD FOR SUBSEA COMPONENTS

A relief valve for a pressure vessel includes a housing having an inner bore extending between an inlet and an outlet, a piston located within the inner bore, a spring disposed about the piston and configured to bias the piston into a closed position, a test port in communication with the inner bore, a removable test plug sealingly disposed within the test port, and a first seal and a second seal disposed within the inner bore on either side of the test port, the first and second seals configured to engage the piston and hydraulically isolate the inlet from the outlet when the piston is in the closed position.
APPARATUS HAVING A FIRST AND A SECOND ROBOT AND METHOD FOR OPERATION THEREOF

The invention relates to an apparatus, comprising a first robot (2) for handling at least one first workpiece (4) in a first processing operation of the apparatus, a second robot (6) co-operating with the first robot (2) for processing the at least one first workpiece (4) in the first processing operation, and at least one first workpiece holder (8) for holding the at least one first workpiece (4) during the first processing operation. The aim of the invention is to improve robot-assisted processing of workpieces (4, 10) which differ from one another. This aim is achieved, according to the invention, in that the first robot (2) is designed and configured for handling at least one second workpiece (10) and the second robot (6) is designed and configured for processing the at least one second workpiece (10) in a second processing operation of the apparatus, the first robot (2) and/or the second robot (6) being designed and configured in order, in a conversion operation of the apparatus, to replace the at least one first workpiece holder (8) automatically by at least one second workpiece holder (12) for holding the at least one second workpiece (10) during the second processing operation. The invention further relates to a method for operating an apparatus.
Synthesis and structure of novel strontium complexes of unsymmetrically functionalized β-diketimine ligands

Abstract A series of tridentate β-diketiminate ligands, (2Z,4E)-4-{[2-(dimethylamino)ethyl]imino}-N-(propan-2-yl)pent-2-en-2-amine (L1H), (2Z,4E)-4-{[3-(dimethylamino)propyl]imino}-N-(tert-butyl)pent-2-en-2-amine (L2H), and (2Z,4E)-4-{[3-(dimethyl-amino)propyl]imino}-N-(propan-2-yl)pent-2-en-2-amine (L3H), and their strontium complexes, SrL 2 1 (1), SrL 2 2 (2), and SrL 2 3 (3) were synthesized as potential strontium precursors, by the reaction of Sr[N(SiMe3)2]2 and two equivalents of L1H, L2H, and L3H, respectively. Compounds 1–3 were characterized by spectroscopic (IR, MS, 1H and 13C NMR), microanalytical methods, and single crystal X-ray diffractometry. The X-ray crystal structure reveals that complex 1 has a monoclinic space group, C2/c. The structure shows the bonding of two β-diketiminate ligands to the strontium metal through six nitrogen atoms. Additionally, the isopropyl groups on the ligands force 1 to attain a highly distorted octahedron. Thermogravimetric analyses of the compounds 1–3 exhibit a primary mass loss on 130–300 °C region.
HDAC inhibitors

Disclosed herein are compounds of formula (I), and methods of inhibiting histone deacetylase ("HDAC") enzymes (e.g., HDAC1, HDAC2, and HDAC3) using compounds of formula (I).
miniatura al f. 177r del manoscritto Yates Thompson 36 della British Library

Nella miniatura al f. 177r del manoscritto Yates Thompson 36 della British Library, Giovanni di Paolo, mette in scena con dovizia di particolari l’invettiva accorata, pronunciata da san Pietro nel canto XXVII del Paradiso ai versi 19-66. L’artista fornisce un’interpretazione figurale particolarmente attinente al testo, dove anche quei particolari che a prima vista potrebbero risultare estranei o difficilmente comprensibili, si spiegano attraverso l’adesione a una tradizione figurativa ancora incardinata nella cultura del Medioevo, quella delle profezie papali figurate, cui lo stesso Dante fece ricorso in più luoghi della Commedia. Si tratta di un recupero in piena aderenza al testo, attraverso il quale l’artista senese intende esplicitare consapevolmente anche certe ricercate allusioni figurali, già contenute nell’invettiva del principe degli apostoli e confacenti all’epilogo segnatamente profetico.
Institutions for knowledge intensive development: economic and regulatory aspects in south-east asian transition economies

The prioritisation and deployment of knowledge within an economy remains a key success factor for long-term economic development, increased productivity and socio-economic sustainability. The achievement of knowledge-driven growth is particularly challenging for emerging market economies that are still seeking to catch up to the frontier knowledge economies. The project seeks to understand the causes and consequences of the differences in the evolution of knowledge intensity of economies, with particular focus on transition countries in South-East Asia. We aim to identify some key micro and macro level institutional incentives for development towards a knowledge economy, and stimuli for capital allocation into knowledge-based investments. Moreover, we seek to study and outline some key channels for efficient regulation that might contribute to knowledge intensification in a transition economy. The project makes use of frontier empirical research methods, including advanced stochastic frontier analysis and dynamic panel data estimation techniques. The conceptual underpinnings of the project are at the intersection of industrial organisation theories, new institutional economics, development economics, and modern concepts in regulatory efficiency and justice. The project will develop lasting excellence oriented cooperation with South-East Asian universities, and contribute to R&D capacity building based on European academic values. Promoting of the project results through intersectoral knowledge transfer will be an important task. We aim to contribute to social innovation through policy suggestions, and to a paradigm shift regarding the role of institutions in transition processes. The project is a joint effort of Swiss and Estonian universities’ economics and law researchers with transition studies experience from Eastern Europe, and their fellow researchers from Laos, Vietnam and Cambodia with thorough insight into the institutional context in their societies.
Mcodaq is a new benchtop instrument for fraud detection in cosmetics, perfumes, candles and other consumer products, based on nmr and used by technicians without specific analytical chemistry skills

What: Fully automated, multiplexed, turnkey commercial routine system for analysis and confirmation of principal components for fraud detection in cosmetics, perfumes, candles and other consumer products, based on NMR (Nuclear Magnetic Resonance) technology and used by laboratory technicians without specific analytical chemistry skills. 

Why: Latest developments in NMR make it suitable, for the first time, as a routine QC technique to be used in Quality Assurance laboratories. Latest room temperature benchtop NMR instruments have the necessary sensitivity, resolution, robustness, operation simplicity and low operating cost, when combined with software implementation of latest innovations in NMR signal processing, analysis, machine learning and chemometrics. 
Users: Global retailers (e.g., Inditex SA, El Corte Ingles, Primark, Ulta, Sephora, etc. – Inditex declaration of interest in attachment) and the network of global, regional and local analytical contract laboratories used by the industry (e.g., SGS, TÜV SÜD, Bureau Veritas, and Underwriters Laboratory) 

Who: The proposed members of a Phase 2 consortium are the leading benchtop NMR manufacturer (Magritek GmbH, Aachen, Germany), the leading NMR software developer (Mestrelab Research SL, Santiago de Compostela, Spain) and an experienced method development analytical lab (AMSLab, Lugo, Spain). We have advanced prototypes of the hardware and software needed to deliver the proposed solution, and deep understanding of the needs of Inditex SA. 

Aim: The phase 1 project would seek to generalise this understanding to the rest of the market and to decide the most valuable turnkey solutions to be implemented in a fully automated finished product. Success of phase 1 would result in a phase 2 application in July, to fund the development of a final market ready system.