SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Pharmacokinetics of enrofloxacin and marbofloxacin in Japanese quails and common pheasants

The pharmacokinetics of enrofloxacin and marbofloxacin was studied in Japanese quails and common pheasants. Healthy mature birds from both species and both genders were treated intravenously and orally with enrofloxacin (10 mg/kg) and marbofloxacin (5 mg/kg). After intravenous administration enrofloxacin was extensively metabolised to ciprofloxacin. Metabolites of marbofloxacin were not detected. Values of volume of distribution were respectively 4.63 l/kg and 3.67 l/kg for enrofloxacin and 1.56 l/kg and 1.43 l/kg for marbofloxacin. In quails, total body clearance values were higher than those in pheasants and other avian species. After oral application enrofloxacin was rapidly absorbed in quails, more rapidly than marbofloxacin. Pheasants absorbed both antimicrobials at a lower rate. Higher bioavailability was observed for marbofloxacin (118%). Relatively low bioavailability was established in quails for enrofloxacin (26.4%), accompanied by extensive conversion to ciprofloxacin. Generally, quails absorbed and eliminated both fluoroquinolones more rapidly than pheasants; the latter showed pharmacokinetics similar to poultry. Because of favourable pharmacokinetic properties, marbofloxacin should be preferred for oral administration in Japanese quails and pheasants for treatment of infections caused by equally susceptible pathogens.
Understanding the relationship between mother-tongue and father-land among german-jewish thinkers of the xx century

National identities are, broadly speaking, built on the historical correspondence between homeland and language. Still, this combination does not apply to Diaspora communities and notably to Jews, whose identity along centuries was rooted in a displaced homeland and spread over distinct languages. How should the bond between homeland and language among German-Jewish thinkers of the XX century be conceptualized? Specifically, what is the exact relationship between mother-tongue and father-land and which role does the gender dimension play in this conceptual pair? How did historical events, such as the Shoah and the foundation of the state of Israel, reshape this relationship? With the aim of examining the bond between language, identities and exile, the HOME-LANG (acronym of the project) will build on my expertise in Jewish contemporary philosophy on the one hand, and on the skills in archival methodologies developed at the University Pompeu Fabra of Barcelona (UPF) on the other. The results of the project will boost my scholarly profile at the international level; they will consolidate UPF as an interdisciplinary hub for cutting-edge research on Diaspora and Jewish studies; finally, they will foster communication between scholars, practitioners and general public at the core of contemporary debates on migration, multiculturalism and the construction of a shared European identity.
Regional cooperation for a Durable Urban Planning

The whole European continent is confronted with the problem of metropolisation which has for corollary a process of greater urbanization and urban spreading. This phenomenon of urban spreading is based on dynamics which exceed very widely the administrative borders to develop on the scale of large territories, that of the competition between cities. It is about a major challenge of the sustainable development there, which depends largely on current realities, namely a governance multiple and burst to the local plan as to the European level. Regions and actors of the Mediterranean metropolitan areas are particularly called on these questionings and are in position privileged to be strength of proposition and mobilization in these initiatives of renewal of the territorial planning in large scales. The present Med project thus proposes experiments relative to the construction of sustainable strategies of development and arrangement coordinated on the scale of big territories, negotiated with an important number of actors to regulate better the metropolisation shapes. He has to end in concrete propositions on target sectors in relevant geographical scales. If the report is shared today, the practices remain isolated what leads a need of exchanges of methods and practices, and a mutualization in the European scale.
Antiapoptotic and Proliferative Effects of Low Concentrations of 7β-Hydroxycholesterol in Human Endothelial Cells via ERK Activation

The atherogenic potential of oxidized low-density lipoproteins (oxLDL) has been correlated to their 7β-hydroxycholesterol (7βOHC) content; oxLDLs have a dual effect on endothelial cell viability, inducing apoptosis or proliferation depending on the concentration. Considering that 7βOHC is apoptotic for endothelial cells at concentrations ≧20 µg/ml, a study on the effect of lower concentrations of 7βOHC on human umbilical vein endothelial cells (HUVECs) was undertaken. 7βOHC (1–10 µg/ml) increased 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide reduction of growth-factor-deprived HUVECs. This effect was due to the increased cell proliferation, determined by [&lt;sup&gt;3&lt;/sup&gt;H]thymidine incorporation, and the reduction of apoptosis, revealed by the decreased caspase-3 activation and annexin V staining. 7βOHC also protected against staurosporine apoptosis. 7βOHC induced an increase in intracellular ROS antagonized by N-acetylcysteine; however, HUVECs treatment with the antioxidant did not inhibit the effects of 7βOHC. 7βOHC produced an increase in extracellular signal-regulated kinase (ERK) phosphorylation that was blocked by inhibitors of store-operated calcium entry 2-aminoethoxydiphenyl borate and gadolinium. MEK inhibition with PD98059 or U0126 as well as store-operated calcium entry inhibition antagonized the effect of 7βOHC. The results suggest that 7βOHC promotes HUVECs survival and proliferation by a mechanism independent of ROS production and involving calcium-dependent activation of ERK.
Cross-border sustainable and intelligent logistics

SMARTLOGI aims to enhance the operational and institutional cooperation on sustainable multimodal freight transport options, tackling the administrative and technological issues currently hindering additional modal shift from road to rail thus decreasing the impact of freight transport in terms of pollution, GHG emissions and noise. This will be achieved through a cross-border action plan (WP3) that will be tested through feasibility studies and joint pilot actions (WP4), leading to the elaboration of a strategy for enhancing cross-border multimodal transport (WP5), that will be
adopted both at operational level by PPs and at institutional level by two EGTCs of the Programme Area, for the creation of a long-term crossborder institutional cooperation framework on freight transport. The project’s results will be used by both PPs and by the other logistic nodes (ports / inland terminals) and policy makers at regional and national level. These are also the main target groups of the project, together with terminal and logistic operators. They will be reached both through wide communication means (e.g. press releases, articles, website) but mainly through dedicated activities (e-newsletters and targeted events). SMARTLOGI will make multimodal transport more competitive and attractive, thus increasing the modal shift from road to rail and contributing to the safeguard of the environment of the whole Programme Area.
Chemical Entity Recognition and Resolution to ChEBI

Chemical entities are ubiquitous through the biomedical literature and the development of text-mining systems that can efficiently identify those entities are required. Due to the lack of available corpora and data resources, the community has focused its efforts in the development of gene and protein named entity recognition systems, but with the release of ChEBI and the availability of an annotated corpus, this task can be addressed. We developed a machine-learning-based method for chemical entity recognition and a lexical-similarity-based method for chemical entity resolution and compared them with Whatizit, a popular-dictionary-based method. Our methods outperformed the dictionary-based method in all tasks, yielding an improvement in F-measure of 20% for the entity recognition task, 2-5% for the entity-resolution task, and 15% for combined entity recognition and resolution tasks.
A Case Study on SUID in Child-Care Facilities

This study investigates a healing process of parents who suddenly lose their child through observing their psychological changes reflected in parents behavioral characteristics based on recent SUID cases. The analysis method used in this study is performed based on the characteristics of a condolence process presented in a case in which a mother loses her child and overcomes her sadness of bereavement through creative painting. In the results of this study, three different periods are presented in the behavioral characteristics of the parent. First, the parent does not accept the death of their child after 1~2 months since their child was passed away and represents anger and violence. Second, although the parent shows certain rational behaviors after 3~4 months since their child was passed away, their emotion still represents unstable states. Third, after 4 months since their child was passed away the parent shows rational judgements and tries to set up new relationships and goals through some efforts to give meaning to the death of their child.
Integration of the study of natural and anthropogenic disturbances using severity gradients

Disturbance is an integral part of every ecosystem, but humans are altering disturbance regimes in fundamental ways that can alter outcomes for ecosystem structure and function. Fortunately, advances in understanding ecosystem responses to natural disturbances can address the ecological consequences of the novel suite of disturbances now created by humans. Complex interactions among both natural and anthropogenic disturbances at many overlapping spatial and temporal scales can be examined across severity gradients. The gradient approach applies ecological tools to differential conditions of stability and fertility, degrees of biological legacy and rates of successional recovery and can help address modern concerns about socio-economic consequences of disturbance and the sustainability of ecosystem services.
The commercial exploitation of mentorship programme outcome intelligence in the global corporate and university market.

The MentorPitch platform www.mentorpitch.com is highly disruptive in a global mentoring context. It is the first platform to automate the management and measurement of large scale mentoring programmes. MentorPitch measures the outcomes of mentoring programmes in a corporate and education environment.  MentorPitch is a Software as a Service (SAAS) cloud-based business. The platform automates the management and measurement of mentorship programmes, thereby reducing the administration time of managing a programme. It is impossible for humans to manually manage and measure the outcomes of large scale mentorships that occur in a mentoring programme. Corporate and university mentoring programme managers face one common problem – how to manually manage a mentoring programme and capture the outcomes of all the mentorships in a specific programme. 

Our objectives for this project are:
1) To commercially validate the outcome intelligence for university student-alumni mentoring programmes and workplace (multinational/corporate) mentoring programmes. We will do so by engaging closely with our current customers (Dublin City University, Transterra Media) and pipeline customers (University of Warwick, INSEAD, HEC Paris, Harvard Business School and corporate mentoring customers) to develop and capture outcomes using our in-house developed technology for large scale mentorship programmes. 
2) The mentor-mentee matching algorithm (based on common skills areas, skills to develop, work experience, education, location and availability), will be developed further and tested to take into account the outcomes of previous mentorships.
3) Prepare a complete Phase 2 business and commercialisation plan, suitable for an SME-Instrument Phase 2 application, including a localisation plan. In phase 2 we plan to localise the content and mobile applications for all key European and international markets, including France, Germany, Italy, Spain, Netherlands, US, Japan and China.
Fish flow innovations tidal turbine

Fish Flow Innovations (FFI) wants to commercialize a fish friendly tidal stream turbine that converts ocean currents into electricity. The turbine can be fixed mounted on a seabed,  tethered/moored to a seabed and/or buoyant, or float on the water surface or in mid water. 

The turbine is designed and constructed to survive in the harsh conditions offshore, and able to efficiently produce electricity in water flows between 3 and 15 m/s without the need for pitch adjustable blades for bi-directional functionality. The turbine has an integrated gravity based support structure, avoiding the need for expensive underwater support structures. The turbine can be deployed in all planned tidal locations worldwide. 

The main objective of the innovation project is to demonstrate and reach market readiness (TRL 9). At the end of the project (January 2019) through certification and an output performance warranty, a commercially viable levelized Cost of Energy of 10 c€/kWh will have been demonstrated in real-sea conditions (provided in the Tidal Technology Center Grevelingendam  in The Netherlands).
HYBRID THREE-DIMENSIONAL WOVEN/LAMINATED STRUTS FOR COMPOSITE STRUCTURAL APPLICATIONS

A woven preform used to reinforce a composite structure which includes a central portion (6,10) having a plurality of interwoven layers. The preform also includes first and second end portions (4,12) having a plurality of independent woven layers (50) that are integrally woven with the plurality o interwoven layers in the central portion (6,10) and which extend along the entire length the preform. Interspersed between the plurality of independent woven layers (50) in the first and second end portions are bias plies (26). The first and second end portions can have through thickness reinforcements (71) comprising reinforcement fibers that traverse through the independent woven layers and the bias plies, locking them together.
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Objective and background: Violence necessitating legal intervention is a common occurrence in the USA. Such legal intervention may include the use of firearms by law enforcement personnel. However, very little is known about such firearm related injuries necessitating medical care. The objective of the present study is to characterize the burden in terms of mortality and emergency department charges of firearm related interventions requiring ED care in USA. Further we sought to identify high-risk cohorts for such injuries. Methods: A nationwide (USA) emergency department sample for the year 2008 through 2010 was used for the present study. All patients treated in an emergency department (ED) due to firearm injuries by law enforcement personnel were selected for analysis. Outcomes examined including mortality in the ED and ED charges. Findings: There were 6144 ED visits due to firearm injuries caused by law enforcement. The mean age was 33 years. Most patients (69.1%) resided in geographic regions designated as low income areas, and the vast majority were males (91.8%). Many patients (39%) were uninsured. For those with insurance, payers included Medicare (5%), Medicaid (13.5%), private (26.5%), and other insurance (15.6%). Following an ED visit 56.9% were discharged as routine, 25.5% were admitted as inpatients, 3.5% were transferred to another short-term hospital, and 2.8% were transferred to a long-term facility. 338 patients died in the ED and 102 patients died following admission as an inpatient. The mean ED charge was US$3631 and total ED charges across the USA was US$12.8 million. Hospitalization and rehabilitation charges were not assessed in this study. Young adults, males, uninsured, and those residing in low-income areas were identified as the high-risk groups involved in firearm related injuries delivered by legal personnel. Nearly 390 children were involved in such injuries. Discussion: Our study offers initial insights into a complex, important, and not an uncommon problem facing the public. Preventive measures and alternative protective strategies should be considered in the high risk cohorts, especially for children. Language: en
EFFICIENT MAPPING OF SIGNAL ELEMENTS TO A LIMITED RANGE OF IDENTIFIERS

The invention generally relates to mapping of signal elements to a limited range of identifiers. The idea according to the invention is to emulate a "virtual" space of identifiers that is larger than the real space of identifiers. The larger virtual identifier space is generally implemented by an intermediate memory (40), which provides storage of identifiers assigned from the real space of identifiers. For each signal element to be mapped to an identifier, the intermediate memory (40) is addressed by means of a hash value (X) calculated from at least part of the signal element, thus allowing access to an identifier. The larger virtual space gives a better distribution of signal elements to the identifiers, and is a key feature for reducing the probability of different signal elements being mapped to the same identifier (clashing). For an efficient reduction of the clashing probability, identifiers with a low probability of being active are assigned to the intermediate memory (40) to represent new signal elements.
Investing in sustainable blue growth and competitiveness through 3-Pillar Business Model (3-PBM)

I@blue will contribute to the sustainable relaunch of yachting sector (shipbuilding, nautical services, tourism) creating a Med transnational network to help the economic upturn by sharing business models (BM) which integrate the 3 pillars of sustainability (environmental, social, economic), developing the “3-PBM” methodology.The sector is now facing crisis and unemployment challenges, but a focus only on economic aspect would represent a threat for the Med ecosystem balance, from an environmental and a social viewpoint.“3-PBM” application and the systematic data collection will create a database providing: a critical mass of knowledge about Med yachting in terms of economic impact, employment, strengths, weaknesses and sustainability, exploitable by several users (SMEs, policy makers, researchers); an indicator system about the sustainability of the yachting enterprises, useful to the policy makers for a better resource allocation and for impact evaluation; a collection of best practices, innovation patterns and policies exploitable by Med yachting sector actors for performance improvement; training material for the realization of sustainable BM in yachting, going towards circular economy principles, and for the maritime tourists for improving awareness about rules for Med safeguard.A transnational action will allow a sustainable development of the whole yachting sector of the Med, protecting at the same time nature, beauty and culture of its territories and its people.
PROGRESS, DESTRUCTION, AND THE ANTHROPOCENE

Abstract: Enlightenment era optimism that technological and educational developments offer a progressive path to plenty and liberation supports a hope that human toil may be progressively reduced. The Development Thesis defended by G. A. Cohen is a piece of that Enlightenment optimism. The Development Thesis holds that productive forces tend to develop throughout history. The tendency for such an increase in productive forces to occur is, according to Cohen’s argument, due to persistent facts about human nature. If Cohen is correct, there is a tendency toward progress of an important sort, and this progress is due in significant part to human nature. But the development of productive forces also destroys nonhuman natural value. In the era of the Anthropocene this is occurring on a planetary scale. The simultaneous development and destruction entails that claims of progress must rely on an all-things-considered judgment. But due to the plurality of the relevant values, which cannot be compared according to a common metric, rational disagreement about the existence of progress and our progressive nature can be expected to persist.
Fatigue Severity and Factors Associated with High Fatigue Levels in Korean Patients with Inflammatory Bowel Disease

Many patients with inflammatory bowel disease (IBD) often complain of fatigue. To date, only a few studies in Western countries have focused on fatigue related to IBD, and fatigue has never been specifically studied in Asian IBD patients. The aim of the present study was to investigate the fatigue level and fatigue-related factors among Korean IBD patients.Patients in remission or with mild to moderate IBD were included. Fatigue was assessed using the Functional Assessment of Chronic Illness Therapy-Fatigue and the Brief Fatigue Inventory. Corresponding healthy controls (HCs) also completed both fatigue questionnaires.Sixty patients with Crohn disease and 68 patients with ulcerative colitis (UC) were eligible for analysis. The comparison group consisted of 92 HCs. Compared with the HCs, both IBD groups were associated with greater levels of fatigue (p<0.001). Factors influencing the fatigue score in UC patients included anemia and a high erythrocyte sedimentation rate (ESR).Greater levels of fatigue were detected in Korean IBD patients compared with HCs. Anemia and ESR were determinants of fatigue in UC patients. Physicians need to be aware of fatigue as one of the important symptoms of IBD to better understand the impact of fatigue on health-related quality of life.
PULLEY OR DISK BRAKING DEVICE

Braking device, particularly for slowing a pulley or a disk, comprising a body (10) fixed to a casing (20) and a braking yoke (30) able to move between a brake-released position and a braking position, said mobile braking yoke (30) comprising at least one friction pad (40) designed to interact, in the braking position, with an element (50) that is to be slowed, such as a disk or a pulley, that has at least one cylindrical surface (51), said element (50) that is to be slowed being mounted such that it can rotate on said casing (20), said brake pad (40), in the braking position, being pressed firmly against said cylindrical surface (51) of said element (50) that is to be slowed, said at least one friction pad (40) being fixed, such that it cannot pivot, to said braking yoke (30), and said body (10) being fixed to said casing (20) by two attachments (100, 200), a first attachment (100) effected about a first axis (A), and a second attachment (200) effected about a second axis (B), said second axis (B) being inclined with respect to and, in particular, perpendicular to, said first axis (A).