SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Development of dialive, a novel liver dialysis device for the treatment of patients with acute on chronic liver failure (aclf)

Liver disease incidence is increasing and about 170K patients die from liver failure each year in Europe. In liver failure, the accumulation of protein bound toxins and increased susceptibility to infection cause multiorgan failure and death. Liver transplantation is the only treatment known to prolong the life but is limited by availability of organs. A clinically efficacious ‘liver dialysis device’ is an unmet clinical need. The ALIVER Consortium has developed and optimised a novel ‘liver dialysis device’, DIALIVE. The DIALIVE device is protected by world-wide patents and is based upon our discovery that (i) albumin, a circulating protein involved in detoxification is reduced irreversibly in function and (ii) endotoxemia contributes to increased risk of infection in liver failure. DIALIVE incorporates albumin removal and replacement and, endotoxin removal and is a TRL5. In animal models of liver failure, DIALIVE was shown to be easy to use, safe, reduced endotoxemia and, improved albumin and immune function and, prolonged survival. The ALIVER Consortium, which is comprised of experts in liver failure, SMEs and charities proposes to perform clinical trials of DIALIVE in patients with acute on chronic liver failure (ACLF). During the grant period a CE-mark will be obtained and the device will progress to a TRL7/8. Consultation with Regulatory bodies confirms that if the trials are successful, a CE-mark is highly likely. Grifols, a large plasma proteins company is a potential licensee of the technology if the studies proposed by the ALIVER Consortium are positive. 
We plan to take the project through regulatory and ethics approval and perform a study to define its safety in ACLF patients in 18 European hospitals; define health economic benefits to the EU and define a reimbursement strategy. The results will be disseminated widely and results exploited to benefit patients, EU healthcare system, create new jobs and grow healthcare Industry in Europe.
Sustainability vs economic growth: a third world perspective

Purpose – The rising dominance of sustainable development (SD) and green growth (GG) in contemporary societies have become one of the foremost sources of contentions that most states face today in the developing world. It is often suggested that institutionalizing key policies of the SD and GG present a win-win situation. The purpose of this paper is to scrutinize and evaluate such a debate in the light of existing empirical evidence on SD, GG and economic development (ED). It seeks to answer the question “does the sustainability discourse fit in the modern socioeconomic needs of the developing nations or not.” Design/methodology/approach – This paper adopts a qualitative research technique. It mainly relies on secondary sources of data. In aligning with key technical approach of qualitative research; the secondary sourced data were also subject to content and thematic analyses from which facts, and assumptions were derived to undertake the present study. Findings – The main verdict of the paper is that SD and GG discourses do not fit in the crucial socioeconomic needs of the underdeveloped nations. Endorsing SD and GG policies in emerging countries is essentially about restraining their economic prosperity. In fact, it is an anti-growth agenda in its essence. What makes it anti-growth is the core element of minimal use of critical natural capital to grow economically, which lies at the heart of entire SD and GG. What makes it hard for the emerging nations to comply with core elements of the sustainability is their capacity to comply with alternative growth pathways. Thus, limiting the growth process by promoting the agendas of SD is fundamentally about keeping deprived state/people poor. Research limitations/implications – The work is exclusively limited to the author’s understanding of issues and key concerns of developing world concerning institutionalization of the SD and GG. The author’s comprehension may not fully reflect the foremost concerns of the emerging nations. Moreover, Just a single research approach was employed in this study. A further empirical investigation is required in this field for acknowledging and documenting all the key motives and perspectives of third-world states when endorsing SD and GG policies. Originality/value – The paper sheds light on the political aspects of promoting the SD, and the long-lasting fact that the key concerns of sustainability pose challenges to the very existence poor states in the south. Most of them are highly exposed to socioeconomic shocks. They cannot afford to implement the policies of SD and GG as the majority of their citizens are living under poverty line. The only panacea they have to overcome the existing social deprivation is the massive ED. Furthermore, institutionalizing SD and GG may cause societal clashes in the poor states.
Injectable wireless microsensors based on the eaxon technology

Within the eAXON project, which is funded by an ERC CoG, we are developing a technology for neuroprosthetics which consists of wireless microstimulators whose operation is based on rectification of galvanically conducted bursts of high frequency current. In addition to the microstimulators technology, we have conceived and protected a technology for the development of implantable sensing systems with an unprecedented level of minimal invasiveness. The sensing technology consists of a very thin implant and an external unit able to wirelessly interrogate the implant for obtaining measurements related to physical or chemical magnitudes in the implant or in its vicinity. In contrast to previous implantable sensing technologies, our technology allows the implementation of thread-like implants; flexible and very thin (diameter < 1 mm). Such level of miniaturization is possible because our technology avoids the need of bulky components within the implants (e.g. batteries or coils) for power and communications. The proposed PoC project is essentially intended to pave the way for a spin-off company aimed at further developing and clinically validating the technology for a specific clinical need.
UC Pd: A New Form of Pd/C for Sonogashira Couplings

Screening of different sources of Pd/C shows reagents of highly variable nanoparticle sizes and oxidation states of the metal. Typically, catalysts with higher surface area are viewed as likely to be the more reactive. In this paper a new form of Pd/C, "UC Pd" is described that is shown to contain larger nanoparticles yet it is the most reactive catalyst of those sold commercially for Sonogashira coupling reactions. UC Pd functions efficiently in the absence of a copper co-catalyst, under very mild and "green" conditions using inexpensive 95% EtOH at 50 degrees C. It is also the only form of Pd/C that can be recycled. In side-by-side reactions with several commercially available forms of Pd/C, none compete successfully with UC Pd under standardized conditions. Physical data obtained from extensive surface analysis using TEM, XRD, XPS, and CO-TPD measurements lead to an explanation behind the unique reactivity of this new recyclable form of Pd/C.
Desenvolvimento de tecnologias inovadoras para a produção de mosto de cerveja utilizando resíduos alimentares, como substituição parcial do malte da cervejaria, utilizando o método de imersão/condicionamento

O projeto consistirá na criação, no prazo de 14 meses, de um novo método de tecnologia de produção adaptado à utilização de diferentes tipos de pão, independentemente da origem, dos métodos de produção e do grau de teor de sal, para que possa ser utilizado para a produção de cerveja sem efeitos secundários sob a forma de sabor salgado e o desenvolvimento de duas receitas de cerveja baseadas no novo mosto utilizando tipos incomuns de Saccharomyces cerevisiae diastaticus e lactobacilo bacteriano e, como resultado, a implementação dos conhecimentos adquiridos à empresa através do início da produção e a possibilidade de oferecer novas cervejas nos próximos cinco meses. O projeto será testado e refinada técnica de produção utilizando o acondicionamento e imersão de pão desperdiçado. O projeto será inovador em escala nacional e tecnologia universal de produção de mosto de malte com parâmetros qualitativos de concentração de extrato, teor de nitrogênio de amina livre, concentração de magnésio, zinco, íons de cálcio semelhantes ou mais favoráveis que o mosto de malte de cevada, bem como a partir de resíduos de pão produzido atualmente pela mistura de malte de cevada e resíduos de pão no processo de trituração. O processo consistirá em criar um novo acabamento, adaptado ao uso de diferentes tipos de pão, para que possa ser usado para produzir cerveja, sem efeitos colaterais na forma de sabor salgado e desenvolver 3 tipos de ervas. Outro. produto consistirá na implementação de novos tipos de cervejas acidificadas e no desenvolvimento de 2 receitas. Graças à implementação dos resultados da pesquisa:1. seremos capazes de aumentar a capacidade da empresa e aumentar a disponibilidade de resíduos de padaria para uso na produção para aumentar a capacidade de produção em pelo menos 200. 2. Nós seremos capazes de aumentar a oferta de produtos disponíveis oferecendo novos tipos de cerveja acidificada usando tipos incomuns de levedura e bactérias.
Local and landscape effects of agricultural intensification on Carabid community structure and weed seed predation in a perennial cropping system

The effects of agricultural intensification on service-providing communities remain poorly studied in perennial cropping systems. However, such systems differ greatly from annual cropping systems in terms of spatio-temporal dynamics and levels of disturbance. Identifying how land use changes at different scales affect communities and ecosystem services in those habitats is of major importance. Our objectives were to examine the effects of local and landscape agricultural intensification on ground beetle community structure and weed seed predation services. We examined the effects of local vegetation management and landscape context on ground beetle community structure and weed seed predation in 20 vineyards of southwestern France in 2013 and 2014. Vineyards were selected along a landscape complexity gradient and experienced different management of local vegetation. The activity-density of ground beetles decreased with increasing landscape complexity while species richness and evenness remained unchanged. Phytophagous and macropterous species dominated ground beetle communities. Seed predation was positively related to the activity-density of one species, Harpalus dimidiatus, and was not affected by local management or landscape context. We found that within-year temporal diversity in ground beetle assemblages increased with landscape complexity. Our study shows that increasing the proportion of semi-natural habitats in vineyard landscapes enhances the temporal diversity of ground beetles. However, we also found that measures targeting specific species delivering biological control services are a reasonable strategy if we are to maximize natural pest control services such as weed seed regulation to support crop production and reduce agrochemical use.
An innovative screening protocol device for early identification of neonates at high-risk for autism spectrum disorders

Autism spectrum disorders (ASD) comprise an early-onset neurodevelopmental syndrome primarily characterized by impairments in social perception, cognition and communication, and a restricted pattern of interests and behavior. Without any doubt, infants and children with ASD greatly benefit from early behavioral intervention, therefore an early detection and treatment of ASD has been placed as a major health care priority. Unfortunately, nowadays, ASD diagnosis occurs at 2.5-4 years of age. In my previous ERC AdG Project, I proved that inborn predispositions to visual social stimuli (i.e., face-like patterns, eye-gaze and biological motion) is different between newborns at high-risk for ASD (HR, younger siblings of affected children) and newborns at low-risk (LR). Significant predictors for HR newborns were obtained and an accurate biomarker was identified. Starting from this, the goal of MoViS Project (Mobile Visual Stimulation) will be to develop, for the very first time, a simple and innovative tool for early screening and monitoring of neonates social behaviour by means of visual stimulation. This is an innovative and a promising project because, behind providing an important contribution in expanding our current knowledge about the ontogenesis of the ASD, the possibility of targeting high-risk infants during the first days of their life, via a behavioral marker for social orienting, could allow for a new generation of early therapeutic interventions for rehabilitation, starting in a time when brain plasticity allows reorganization of cortical circuits.
Métabolites dérivés du microbiote intestinal et déclin cognitif : une exploration de l’axe intestin-cerveau

Le microbiote intestinal (MI) participe à la digestion et au métabolisme de nombreux nutriments en libérant des métabolites dans le tube digestif, dont certains gagnent la circulation sanguine et traversent la barrière hémato-encéphalique, interagissant ainsi directement avec le cerveau. Cependant, les connaissances sur le lien entre MI et santé cérébrale sont en grande partie précliniques, et peu d’études ont porté sur les métabolites microbiotiques circulants et le vieillissement cognitif chez l’homme. L’objectif de cette étude était d’analyser et de valider, dans un cas-témoin niché dans une grande cohorte de sujets âgés, l’association entre des dizaines de métabolites sanguins dérivés du MI et le déclin cognitif au long cours. Cette étude met à profit les données de la cohorte des trois-cités (3C, Bordeaux, Dijon et Montpellier) chez des personnes âgées de 65 ans ou plus à l’inclusion. Les participants non déments au moment du prélèvement sanguin et dont la cognition a été mesurée de façon répétée au cours des 12 années suivantes étaient éligibles pour le cas-témoin niché. Un échantillon de découverte a été défini dans 3C Bordeaux, incluant les 209 participants avec la pente de déclin cognitif la plus importante, appariés à 209 témoins avec une cognition plus stable (pente > pente médiane) et de même âge, sexe et niveau d’études. Un échantillon de validation a été défini de façon similaire dans 3C Dijon (210 paires cas-témoin). Une analyse en métabolomique ciblée a permis de quantifier 76 métabolites liés à l’alimentation et potentiellement dérivés du MI. L’association entre chaque métabolite et le déclin cognitif a été étudiée dans l’échantillon de découverte en utilisant des régressions logistiques conditionnelles. Les métabolites dont la P-valeur corrigée pour les tests multiples (FDR) était ≤ 0,15 ont été testés pour réplication. 7 métabolites étaient associés au déclin cognitif avec une P-FDR ≤ 0,15 dans l’échantillon de découverte : la phénylacétylglutamine, l’acide indole-lactique, l’acide kynurénique, la bétaïne, la vitamine B5, le propionate et le 3,4-DHPV-S. Seul le propionate était répliqué (OR = 1,26, 95 % IC [1,02 ;1,55]). Cette association était atténuée de façon importante après ajustement sur les facteurs de risque cardiométaboliques dans l’échantillon de validation (une population à risque vasculaire plus important que la population de découverte). Cette étude suggère une relation délétère entre l’acide propionique circulant et le déclin cognitif. Le rôle de la santé cardiométabolique dans cette relation mérite d’être approfondi.
Biochemical and Metabolic Changes in Arsenic ContaminatedBoehmeria niveaL.

Arsenic (As) is identified by the EPA as the third highest toxic inorganic contaminant. Almost every 9th or 10th human in more than 70 countries including mainland China is affected by As. Arsenic along with other toxins not only affects human life but also creates alarming situations such as the deterioration of farm lands and desertion of industrial/mining lands. Researchers and administrators have agreed to opt for phytoremediation of As over costly cleanups. Boehmeria nivea L. can soak up various heavy metals, such as Sb, Cd, Pb, and Zn. But the effect of As pollution on the biology and metabolism of B. nivea has been somewhat overlooked. This study attempts to evaluate the extent of As resistance, chlorophyll content, and metabolic changes in As-polluted (5, 10, 15, and 20 mg L −1 As) B. nivea in hydroponics. Toxic effects of As in the form of inhibited growth were apparent at the highest level of added As. The significant changes in the chlorophyll, electrolyte leakage, and H 2 O 2 , significant increases in As in plant parts, catalase (CAT), and malondialdehyde (MDA), with applied As revealed the potential of B. nivea for As decontamination. By employing the metabolic machinery of B. nivea , As was sustainably removed from the contaminated areas.
Geochemistry of the Mesoarchean Fiskenæsset Complex at Majorqap qâva, SW Greenland: Evidence for two different magma compositions

Abstract The Mesoarchean Fiskenaesset Complex was emplaced as multiple sills and dykes of magma and crystal mush into oceanic crust, forming an association of ca. 550-meter-thick layered anorthosites, leucogabbros, gabbros, hornblendites, pyroxenites, dunites, and peridotites. The complex was intruded by tonalites, trondhjemites and granodiorites (TTG), and underwent multiple phases of deformation. The Fiskenaesset Complex and bordering TTG intrusions were variably affected by granulite facies metamorphism and retrogressed under amphibolite facies conditions. This study presents new field, petrographic, and major and trace element geochemical data for the six major stratigraphic units of the Fiskenaesset Complex at Majorqap qâva, SW Greenland. In addition, new high-precision trace element data are reported for hornblendes from three stratigraphic units. The sampled major lithological units from bottom to top are: Lower Gabbro, Ultramafic, Lower Leucogabbro, Middle Gabbro, Upper Leucogabbro, and Anorthosite. Both whole-rock and hornblende trace element data are consistent with crystallization of the complex from two different parental magmas, originating from different mantle sources. Subsequent differentiation of these parental magmas in the oceanic arc crust resulted in two evolved geochemical rock suites (Suite A and Suite B), which are both characterized by depletions of HFSE (Nb, Ta, Zr and Hf) relative to Th, U, LREE and LILE (Rb, Ba), and enrichments of Sr and Pb relative to MREE; these data are consistent with a magmatic arc geodynamic setting.
Acquisition of new 3D printing equipment

Purchase of new output equipment, which will double the manufacturing capacity. The number of future jobs will also increase by one. Order a new software license for the processing of Netfabb files.
An online optimization algorithm for coordinated control of VSC-HVDC link and DFIGs for offshore wind applications

The aim of this paper is to find out an optimization algorithm for wind power plants, where the wind turbines are equipped by DFIG, connected to on-shore grid by means VSC-HVDC link. The off-shore grid frequency is assumed variable under a fixed range and the wind power tracking characteristic of the DFIG has to be extended to consider the additional grid frequency dependence. The highly non linear problem is solved by means of a interior point algorithm and a sequential quadratic programming algorithm. The methodology has been tested on a wind park composed by 50 turbines. Results show that the best operation point is quickly reached, demonstrating the effectiveness of the tool for online operations.
Slow growth in the Mexican economy

The goal of this paper is to test alternative explanations of slow growth in the Mexican economy. There are two groups of explanations: The first, closer to the government's position, considers the cause to be the lack of completion of structural reforms, in particular: liberalization of the labor market and foreign investment, and full privatization of the oil sector. The second, proposed by academics and independent economic research centers underlines the negative effect of the neoliberal fiscal and monetary policy applied in the Mexican economy for the past thirty years. In the academic debate held by this second group of economists there is a belief that, directly or indirectly, poverty and the income concentration are related to Mexico's weak growth performance. This article, grounded in post Keynesian and Kaleckian theory, uses econometric models to provide evidence that the principal cause of the slow growth of the Mexican economy is income concentration, and concludes that the strategy of neolibe...
Monitoring, forcasting and best practices for FLOOD Mitigation and prevEntion in the CADSES region

Hydro-meteorological monitoring and flood forecasting are indispensable for preventing and mitigating hydrological hazards, such as floods, and for ensuring civil protection. Implementing a plan that acknowledges the principles of sustainability to combat floods requires further activities regarding agriculture, forestry and land-use management in flood risk areas. As most river catchments areas belong to more than one country or region, methodologies have to be developed within a transnational and a transregional context that go beyond local concepts. The project regions of FLOODMED are characterised by an increase in the number of people and economic assets located in flood risk zones, while at the same time the areas lack an integrated flood management plan. The project aims at developing effective flood risk management programs, incorporating the basic elements of flood prevention, protection, preparedness, emergency response and recovery. FLOODMED brings together scientists and public servants who will develop a scalable system of operational tools to support integrated water and sustainable flood risk management.
Design and analysis of compact work-recovery phase shifter for pulse tube refrigerator

Abstract This paper proposes and describes a compact work-recovery phase shifter of a pulse tube refrigerator. Most pulse tube refrigerators recently developed utilize a long inertance tube and a reservoir for phase control between dynamic pressure and mass flow rate at the cold-end of pulse tube refrigerators. An inertance tube-type phase shifter (long inertance tube and reservoir), however, sometimes creates a problem of compact packaging in cryocooler applications and dissipates the work transferred from a compressor as heat. To overcome this disadvantage, an inertance tube-type phase shifter is replaced with a compact work-recovery phase shifter composed of a mass–spring–damper system and a linear generator in a pulse tube refrigerator. This process is achieved by using analogy of the inertance tube-type phase shifter and the mass–spring–damper system. This paper describes a specific configuration of the designed compact work-recovery phase shifter. Using the simulation code, the performance of the pulse tube refrigerator with the compact work-recovery phase shifter is estimated. As a result, the pulse tube refrigerator with the compact work-recovery phase shifter has the comparable cooling capacity with the pulse tube refrigerator with the inertance tube-type phase shifter. If the recovery work is properly utilized, it can also achieve higher efficiency than that of the pulse tube refrigerator with a typical inertance tube-type phase shifter. In this paper, the parametric study of the mass, the spring and damper coefficients of the compact work-recovery phase shifter has been done and their effects are specifically evaluated.