SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Selectively targeting oscillations in parkinson's disease: causal effects of the beta-rhythm on motor control

Parkinson’s disease is a frequent and disabling neurological disorder, which heavily impairs patients’ ability to perform and control movements. Electrical stimulation of a deep-seated brain region, the subthalamic nucleus (STN), has been shown to significantly improve patients’ motor function and quality of life. Recent technological advances in deep brain stimulation (DBS) render it possible to adjust electrical stimulation of the STN to ongoing brain activity, referred to as closed-loop DBS. Here, the implanted electrodes do not only send signals to the brain but also read out neural signals generated by the brain. Closed-loop DBS offers the intriguing possibility to specifically suppress pathological brain activity while leaving physiological activity unaltered. 
We propose an innovative and ambitious project, which the researcher will conduct in the Experimental Neurology group headed by Prof. Peter Brown at the University of Oxford, a world-leading laboratory in closed-loop stimulation. In this project we aim to test the hypothesis that closed-loop DBS that selectively targets pathological synchronous firing of neurons at 13 – 30 Hz, the so-called beta-rhythm, will interrupt neural activity related to motor impairment, but not normal functions of the brain. To this end, Parkinson patients with implanted electrodes in the STN will perform two tasks probing different aspects of motor control whilst receiving closed loop stimulation. We will simultaneously record activity from the STN and areas localized on the surface of the brain. This will allow us to assess how suppression of the beta-rhythm affects motor-related activity and connectivity in the human brain revealing it’s causal effects on motor function. Selective suppression of abnormal brain function and preservation of physiological brain mechanisms could be the key to obtain the best possible clinical benefit, whilst avoiding unwanted side effects in the treatment of Parkinson’s disease.
Ordination as a tool to characterize soil particle size distribution, applied to an elevation gradient at the north slope of the Middle Kunlun Mountains

article i nfo Soil particle-size distribution (PSD) is one of the most fundamental physical attributes of soil due to its strong influence on other soil properties related to water movement, productivity, and soil erosion. Characterizing variation of PSD in soils is an important issue in environmental research. Using ordination methods to characterize particle size distributions (PSDs) on a small-scale is very limited. In this paper, we selected the Cele River Basin on the north slope of the Middle Kunlun Mountains as a study area and investigated vegetation and soil conditions from 1960 to 4070 m a.s.l. Soil particle-size distributions obtained by laser diffractometry were used as a source data matrix. The Canonical Correspondence Analysis (CCA) ordination was applied to analyse the variation characteristics of PSDs and the relationships between PSDs and environmental factors. Moreover, single fractal dimensions were calculated to support the interpretation of the ordination results. Our results indicate that a differentiation of 16 particle fractions can sufficiently characterize the PSDs in CCA biplots. Elevation has the greatest effect on PSDs: the soil fine fractions increase gradually with increasing elevation. In addition, soil pH, water and total salt content are significantly correlated with PSDs. CCA ordination biplots show that soil and vegetation patterns correspond with one another, indicating a tight link between soil PSDs and plant communities on a small scale in arid regions. The results of fractal dimensions analysis were rather similar to CCA ordination results, but they yielded less detailed information about PSDs. Our study shows that ordination methods can be beneficially used in research into PSDs and, combined with fractal measures, can provide comprehensive information about PSDs.
Design and Sensitive Configurations: Memory and Learning Neural Circuits Correlated with the Creative Processes in Design

The current study demonstrates an articulation between the learning and memory mental processes that organize our sensitive perception and creative process in design. Based on Eric Kandel’s research on the multiple forms of learning using Aplysia californica (a giant sea slug), we have established correlated visual graphics that approach learning neural analogs to the apprehension of the sensible. The contemporary design sets subjective aspects of our being in the world, engendering modes of action that determine our behavior in everyday life. The aim of the current study is to reflect on didactic strategies and procedures that enhance the emergence of creative minds.
Efecto del riego y la poda en el contenido de componentes menores y ácidos grasos del aceite de oliva virgen varietal Farga

The effect of different irrigation and pruning strategies on the amount of substances related to the oxidative stability of virgin olive oils of the variety Farga (polyphenols, chlorophylls, carotenoids and fatty acids), was analyzed. Four treatments were used: T100%SP (irrigation supplying 100% of the plants’ evaporative transpiration demand (Etc) during the entire cycle, without winter pruning); T50%SP (irrigation supplying 50% of the plants’ Etc from pit hardening to harvest, without winter pruning); T100%CP (irrigation supplying 100%, with pruning) and T50%CP (irrigation supplying 50%, with pruning). The plants’ hydric status was monitored through the stem hydric potential (SHP) at noon, and the soil moisture content and the photosynthetically active incident radiation within the tree branches were determined. The olive sampling was taken from pre-ripening to full maturity. The oil was extracted from the olives by grinding them in a laboratory screw type mill with thermo-kneading. The separation of solid and liquid phases was performed using a hand press and decanter to remove the oil. Chlorophylls and carotenoids (absorbance at 670 nm and 472 nm) and total polyphenols (at 725 nm), were determined by spectrophotometry on the mechanically extracted oil. Fatty acids were determined by capillary gas chromatography (CGC). Oil yield data show no statistical differences between deficit irrigation covering 50% of the ETc and the control treatment, both in plants with or without pruning. The contents of polyphenols, chlorophylls and carotenoids in the oils decrease with fruit ripening, regardless of the initial content and treatment. Deficit irrigation treatments (T 50%) have higher contents of polyphenols (except for pre-envero sampling), chlorophylls and carotenoids. There are no statistically significant differences between treatments with and without pruning.
Ancient scholarship on archaic greek iambic poetry

The proposed research concerns ancient scholarship on archaic Greek iambic poetry from the Hellenistic to the Byzantine period. It investigates the history of such scholarship in its various embodiments (editions, commentaries, marginal annotations, monographs on individual topics, author- and genre-specific lexica, and others) and the aims, concerns, assumptions, and techniques that it deployed. This investigation - the first of its kind - aims to contextualise such items of scholarship, and scholarship on iambos generally, within the broader picture of ancient literary scholarship. The study of ancient scholarship is a budding field, making the proposed research timely as well as necessary. Ancient scholarship has long been among my research interests. Given the Department's strengths on archaic Greek poetry and ancient scholarship, and Ca' Foscari's commitment to fostering research and supporting young researchers' skills development, Venice is the ideal partner for the success of the proposed research. Holding a Marie Sklodowska-Curie would be highly beneficial to my academic career and enable me to achieve independence as a professional researcher.
European imu for space navigation

EURISA aims at ensuring long term availability of a European cost-effective and performant IMU based on fiber-optic gyroscopes and quartz accelerometers for the future space missions. As of today, all European missions depend on American IMU, mainly Northrop Grumman LN200S, with no alternative in Europe for compact and cost-effective IMU.

The main goal of the project is to deliver an engineering model of this IMU at TRL equal or higher than 6. The engineering model will be tested in space environments and its inertial performances will be measured and validated. On top of that, the project will also deliver crafted hybridization algorithms to provide the best possible navigation performances

EURISA relies on 4 actors of the European space ecosystem: Airbus Defence & Space, ETH Zurich, DLR Bremen and iXblue. They have all the required competencies and know-hows to make a success out of this project: space electronics, inertial sensors, knowledge on the space mission requirements, hybridization algorithms, space environment and also manufacturing and quality.

In practice, the project will be built on current developments of the partners that have already reached TRL 4 and above: compact fiber-optics gyroscopes, quartz accelerometer, space electronic boards based on COTS and hybridization algorithms. In the frame of EURISA, these different elements will be further developed or adapted, then qualified and finally assembled together to make the future European IMU.
By using current developments and many synergies together with the use of COTS, we ensure a cost-effective product and a safe path toward a TRL 6 maturity.
Bactiline at-line system for automatic monitoring of microbial bacteria in water

The growing population is putting a strain on the world’s water resources while at the same time the ever-developing industrialization is causing increasing occurences of water-contamination, both in potable water sources and in wastewater, which is discharged into rivers and oceans.
To deal with these issues of water contamination, 

Mycometer has developed an automatic early-warning solution, the BactiLine at-line system, which promptly detects elevated levels of bacteria in water systems and sends out a warning when bacteria presence is above tolerated limits. BactiLine can be implemented at main control points in the distribution system, sample the water quality at pre-determined intervals and report to a control database.

The BactiLine system is based on the existing and patented Bactiquant®-water method, which measures the total bacteria presence in a water sample by use of a sensitive fluorescence technology
For end-users the BactiLine solution presents the following benefits: 

i.	Faster response time, as water is sampled several times a day and bacteria counts are reported within minutes of the sampling

ii.	Larger sample sizes, with bacteria concentrated through filtration, minimizes the risk of false positives.

iii.	Improved possibility for remote water quality monitoring through automated sampling from the water source

iv.	More resource-efficient sampling process with the elimination of manual work hours for lab technician

v.	The assay sensitivity can be adjusted in real time, allowing the 

technology to be used in a broad range of water types and applications
With the BactiLine system, Mycometer will target utilities companies, wastewater treatment plants and industrial plants using large amounts of water for production processes, leading to a sales revenue of €7.2M, five years post project.
Comprehensive geographic analysis and discussion on strategies for post-earthquake recovery and reconstruction in Ludian,Yunnan Province

Earthquake area has the most intense interactions between the various spheres of the earth surface and human-environment relationship is under great stress.In-depth comprehensive geographic study has significant implications for the coordination of the human-environment relationship and the promotion of regional sustainable development in such area.This paper analyzes the resource and environmental conditions and regional development of Ludian County before the earthquake.We found that this region has vulnerable ecological environment,high population density,widespread poverty,strong dependence of production and livelihood systems on natural resources,and the resources and environment have been chronically under stress.Accordingly,this paper proposes that an evaluation of the resources and environmental carrying capacity should be carried out imminently for the area,sound recovery and reconstruction plans should be made,regional sustainable development based on innovation of the system and institutions should be promoted,and systematic disaster prevention and reduction research and overall planning at the periphery and in the adjacent mountainous areas of the Qinghai-Tibet Plateau should be initiated.
Development of an in vivo radionuclide generator by labeling bleomycin with 191Os

Bleomycin (BLM) has been labeled with various radioisotopes and widely used in therapy and diagnosis. 191Os is a parent radionuclide with 15.4 day half-life and decays by beta emission to 191mIr, which is a radionuclide with 4.96 s half-life. BLM was labeled with 191Os-hexachloro-osmate and its distribution and stability in wild-type mice was determined. The complex was obtained at the pH 2 in normal saline at 90 °C in 48 h. Radio-TLC showed an overall radiochemical yield of 93–97%, radio-chemical purity > 97%. The biodistribution study for 191Os-hexachloro-osmate and 191Os-BLM were carried in wild type-mice up to 14 days. Lungs, liver and spleen uptake increased 24–72 h after administration of 191Os-BLM. 24 h after administration, the radioactivity of the kidney increased and remained constant.
Mechanical Analysis of Warm Extrusion Precision Forming on 42CrMo Steel Cutting Pick

Cutting pick is a kind of widely-used consumptive mining tool. The traditional producing technics of cutting pick body is foundry, or machining after roughly forging, or machining directly from metal bar. By former technics, the property of products is poor, and by latter, the material availability is low and the cost is high. The patent technology for cutting pick body warm extrusion introduced in this paper can overcome all the disadvantages mentioned above. In this paper, by analyzing the characteristic of cutting pick body warm extrusion, adopting the principle of power balance to solve the approximate solution of strain forces, the approximate calculating formulas of extruding power are deduced. The main factors affecting on extrusion force are determined theoretically. This research can be used as basis to design tooling and choose proper equipment for this new technology.
Science and technology park co-operation in EU-Future Region

TECPARKNET is a network consisting of regions in Austria, Italy, Slovenia, Croatia and Hungary. The expected effects of the establishment of the network address the transnational approach, equal opportunities, environmental issues, employment and economic sectors and spatial development. The aim is to achieve improved competitiveness and a better economic situation for the regions involved. In order to achieve this, co-operation efforts combining economic, scientific and technology resources, comparative strengths and infrastructure have been established. They focus on innovative small- and medium-sized companies, clusters and also aim at promoting new businesses. The exchange of knowledge, competent partners and specialised infrastructure will facilitate integration of the regional economies on a higher level. The companies are at different stage in terms of economic and technology infrastructure but still there is a lot of potential for co-operation.
MAKE-UP COMPACT WITH SEALING JOINT

L'invention est relative à un boîtier comportant un couvercle et un corps de boîtier ajouré, recevant une réserve de produit contenue dans une coupelle. Il comporte un joint d'étanchéité (6) assujetti à la coupelle (5) et s'appliquant de manière étanche sur le corps de boîtier (2).
Chromosome number variations in vivo: probing mechanisms of genesis and elimination

How variations in whole chromosome number impact organism homeostasis remains an open question. Variations to the normal euploid genome content are frequently found in healthy animals and are thought to contribute with phenotypic variability in adverse situations. Yet they are also at the basis of several human diseases, including neuro-developmental disorders and cancer. Our preliminary data shows that physiological aneuploidy can be identified in certain cells during development. Moreover, we have observed that when induced through mutations, non-euploid cells are effectively eliminated from the cycling population. A quantitative view of the frequency of non-euploid karyotypes and the mechanisms underlying their genesis is lacking in the literature. Further, the tissue specific responses at play to eliminate non-euploid cells, when induced through mutations are not understood. The objectives of this proposal are to quantitatively assess the occurrence of physiological chromosome number variations gaining insight into mechanisms involved in generating it. Additionally, we will identify the tissue-specific pathways involved in maintaining organism homeostasis through the elimination of non-euploid cells. We will use a novel genetic approach to monitor individual chromosome loss at the level of the entire organism, combine it with quantitative methods and state-of-the art-microscopy, and focus on two model organisms - Drosophila and mouse - during development and adulthood. We predict that the findings resulting from this proposal will significantly impact the fields of cell, developmental and animal physiology, generating novel concepts that will bridge the existing gaps in the field, and expand our understanding of the links between karyotype variations, animal development and disease establishment.
Evaluation of the quality of image for various breast composition and exposure conditions in digital mammography

Breast density has a close relationship with breast cancer risk. The exposure parameters must be appropriately chosen for
each breast. However, the optimal exposure conditions for digital mammography are uncertain in clinical. The exposure
parameters in digital mammography must be optimized with maximization of image quality and minimization of
radiation dose. We evaluated image quality under different exposure conditions to investigate the most advantageous
tube voltage. For different compressed breast phantom thicknesses and compositions, we measured the Wiener spectrum
(WS), noise-equivalent number of quanta (NEQ), and detective quantum efficiency (DQE). In this study, the
signal-to-noise ratios were derived from a perceived statistical decision theory model with the internal noise of eye-brain
system (SNRi), contrived and studied by Loo et al.1 and Ishida et al.2 These were calculated under a fixed average
glandular dose. The WS values were obtained with a fixed image contrast. For 4-cm-thick and 50% glandular breast
phantoms, the NEQ showed that high voltages gave a superior noise property of images, especially for thick breasts, but
the improvement in the NEQ by tube voltage was not so remarkable. On the other hand, the SNRi value with a Mo filter
was larger than that with a Rh filter. The SNRi increased when the tube voltage decreased. The result differed from those
of WS and NEQ. In this study, the SNRi depended on the contrast of signal. Accuracy should be high with an intense,
low-contrast object.
Microbiological fluorescence observatory for antibiotic resistance tracking

The accurate quantification of microbial populations is critical for understanding how microbes evolve and adapt to stressful environments. This, in turn, can help improve rationales for drug deployment aimed at minimising the evolution of antibiotic resistance. Working on ERC-funded research into how microbial communities optimise their virulence traits and mediate drug-resistance, our team identified a need for a low cost photometry device capable of high-throughput quantification of microbial phenotypes such as microbial growth rates and metabolic efficiencies; microbial dose responses and susceptibility to antibiotics; antibiotic interactions datasets; microbial individuality and heterogeneity data and population mean gene expression profiles for fluorescently labeled genes. There are multiple positive consequences of having these capabilities at low cost: we can create high-throughput data pipelines for microbiology research, particularly for evolutionary studies or phenotypic screens; we can improve the dissemination of high-quality phenotypic data analysis algorithms (such as synergy tests for antibiotics) and so provide standardisation for those phenotypic assays; schools can benefit from the low-costs laboratory hardware and bring data analysis for microbiology into their mathematics, biology or computer science teaching; our lightweight devices with small footprints can be used to access geographically hard-to-reach areas where drug resistance phenotyping could be conducted using either battery or solar power. We are, therefore, now in the process of creating two prototypes that can perform these functions and we are seeking funding to finalise their design and field test the devices in three different settings: a partner research laboratory studying microbial evolution, a hospital research laboratory studying antimicrobial resistance and finally schools in a top-10 deprived area of the UK that cannot afford biotechnology equipment for teaching science.
Death-squads contemplating queers as citizens: what Colombian paramilitaries are saying

Colombian right-wing paramilitary forces aligned with the state and leftist guerrilla groups are associated with homophobic and transphobic attacks. However, the most extreme accounts of violence are attributed to the former group. Sexual and gender minorities are victimized in the ongoing internal conflict in which armed actors use attacks as a form of communicative violence meant to discipline the civilian population. At the same time, Colombian lesbian, gay, bisexual and transgender (LGBT) communities are making significant advances in gaining recognition of their human rights. This article explores the space where the advance of LGBT rights confounds reactionary homophobic beliefs of illegal right-wing armed groups. I consider how concepts such as ‘nation’ and ‘citizen’ shape the discourse of paramilitary forces in their account of their group's homophobic violence. Special attention is paid to the logic provided by two informants, former paramilitary members themselves, regarding the conditions under...
A comprehensive review of alkaline-surfactant-polymer (ASP) flooding

Alkaline–surfactant–polymer (ASP) flooding is a combination process in which alkali, surfactant, and polymer are injected in the same slug. Because of the synergy of these three components, ASP is the current worldwide focus of research and field trial in chemical enhanced oil recovery (EOR).

This paper is to provide a comprehensive review of the ASP process. The reviewed topics include the following: 

ASP synergy and its EOR mechanisms
Screening criteria
Laboratory work
Numerical simulation work
Summary of pilots and large-scale applications
Project economics
Chemicals used
Water quality
Mobility control requirement
Problems associated with ASP flooding and possible solutions


In addition to the comprehensive review, future developments are also discussed. Data and analyzed results presented in this review will provide the reader with the updated information about ASP and a guide to read relevant papers for those who are new to chemical EOR. The survey data also provide operators with some reference data for their project design and optimization. © 2014 Curtin University of Technology and John Wiley & Sons, Ltd.