SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Solution-Phase lighting-emitting devices for optogenetic control of the peripheral nervous system

Delivering light deep into tissue is an important open challenge in biomedical engineering, with particular relevance for optogenetics. One feasible solution is the application of miniaturized bio-implantable light-emitting devices. Such devices should be able to adapt to stimulate cells in tissues with different shapes, sizes, stiffness, and mechanical characteristics. OLED is the most successful light application in current display technologies with many advantages but it cannot adapt to the extreme requirement in three-dimensional structures. The limitations come from the multi-layered device architecture and manufacturing process of vacuum evaporation. Here, we propose a radically different device concept, a solution-phase light-emitting device (sol-LED) with a simple structure that can readily adapt various form factors and thus is of particular relevance to novel applications in the biomedical context. The sol-LED consists of electrodes and a solution that adopts the exciplex host-dye guest system. The fabrication is based on the process under liquid-state such as injection and capillary processes to fill the space in pre-formed devices. The proposed sol-LED will take advantage of existing state-of-the-art OLED materials and established OLED device physics and translate them to the liquid state by dissolving solid-state materials in suitable solvents. Apart from developing this entirely novel type of light source, the use of sol-LEDs as light-source for optogenetics will be developed and tested. Sol-LED with a needle-like shape will be produced by injection of the solution into a hollow microneedle. The resulting devices will be implanted into muscles of the posterior thighs of mice. The motor function will then be mimicked by alternating stimulation of the muscle cells responsible for contraction of the left and right legs. With this, we will test if the device can stimulate cells in vivo with constant intensity and frequency despite strong muscle movements.
Disruptive platform for sustainable and low-cost amino acid production

Serine and Cysteine are two commercially important AAs. However, both present severe limitations regarding their production’s environmental and economic sustainability, which limits their market potential and causing a large negative environmental impact.

Supported by advanced patented-metabolic engineering and synthetic biology approaches Cysbio developed a bio-based platform for AA production - AA-Platform - with an unprecedented environmental and economic performance. Through the design of proprietary cell factories (Escherichia coli), Cysbio was able to combine, balance and tune the different metabolic pathways involved in Ser production. 

The accomplishment of the AA-platform performance  is also due to: i) the sustainable and cost-efficient bioconversion of Ser into Cys; ii) efficient and multi-sourced (i.e. can use sources of glucose, maltose or glycerol with limited impact on process’s efficiency); and iii) sustainable upstream and downstream processes. Building from these strong value propositions, this innovative platform yields a significant advantage against competitors’ products and will radically change the market, by creating the cheapest AAs (Ser<2.1 €/Kg and Cys<2.5€/Kg and longer term the target is >1 €/Kg and >2 €/Kg respectively) and in an environmentally sustainable manner. This will allow companies and society at large to replace fossil-based, energy consuming and polluting processes and products with sustainable, bio-based alternatives.

Cysbio is currently a small and agile company, whose business strategy is to move quickly into the market by taking a large share of the existing Ser and Cys market segments and by creating a new one, replacing part of Met added in the chicken feed (with a market size of 5.4€Bn) with our sustainable and inexpensive Cys. The BioBAA project is at the core of this strategy and is what drives the company´s mission and future activities for a successful development.
Formation Of The Pro-Social Behaviour Among Adolescent Audience Through Exposure To Films

This research studies the relationship between the exposure of films towards the formation of pro-social behaviour among the adolescent audiences. The social cognitive theory was used as the theoretical framework through the observational learning construct and acts as the intervening variable. The cross-sectional survey was employed in this research as the research design. Data were collected from the distribution of questionnaire through the stratified random sampling method. There were 1028 respondents involved in the research. The questionnaire was constructed from the combination of self-developed questionnaire and Prosocial Personality Battery (PSB). The analysis through partial correlation test shows a significant positive relationship between exposure to films (r= 0.246, p <.05) and prosocial behaviour by controlling the intervening variable. Based on the multiple-regression test, exposure to films and observational learning are the main predictor factors that contribute to the prosocial behaviour for 28.3 percent. Keywords : Films exposure, prosocial behaviour, social cognitive theory, observational learning
CYAA-BASED CHIMERIC PROTEINS COMPRISING A HETEROLOGOUS POLYPEPTIDE AND THEIR USES IN THE INDUCTION OF IMMUNE RESPONSES.

The invention relates to a chimeric protein comprising or consisting of, from N-terminal to C-terminal, (a) a N-terminal part of a Bordetella CyaA protein (b) a heterologous polypeptide, and (c) a C-terminal part of a Bordetella CyaA protein. The invention also relates to a polynucleotide encoding a deleted version of a Bordetella CyaA, as well as a polynucleotide encoding this chimeric protein. A composition comprising at least one chimeric protein(s) of the invention and the prophylactic and/or therapeutic uses of said composition are also part of the invention.
Genetic diversity patterns in Curcuma reflect differences in genome size

The relationships between genome size and the systematic and evolutionary patterns in vascular plants are equivocal, although a close relationship between genome size and evolutionary patterns has been previously reported. However, several studies have also revealed the dynamic nature of genome size evolution and its considerable ‘ups’ and ‘downs’. Thus, in this study, the phylogenetic relationships among three previously revealed genome size groups and among species of the highly polyploid genus Curcuma were evaluated using AFLP. Our results suggest two main lineages within Indian Curcuma reflecting evolution of genome size. The first one includes hexaploids and higher polyploids of the previously recognized genome size group I, and the second one includes mainly hexaploids of genome size groups II and III. Within genome size group I, relationships among species seem to be influenced by reticulate evolution and higher polyploids are likely to be of allopolyploid origin. Reproductive systems in Indian Curcuma vary considerably among ploidy levels and these differences considerably affect morphological and genetic variation. In general, clonally reproducing species are expected to exhibit low genotypic diversity, but, at the same time, species of allopolyploid origin are expected to maintain higher levels of heterozygosity compared with their progenitors. We investigated intra-populational genetic variability in Curcuma spp. to evaluate whether mode of reproduction or ploidy represent the main factor influencing the degree of genetic diversity. We found that hexaploid species exhibited significantly higher genetic diversity than higher polyploids (9x, 15x). Our results suggest that this genetic diversity pattern is largely influenced by the mode of reproduction, as higher polyploids reproduce exclusively vegetatively, whereas hexaploids reproduce mainly sexually. © 2011 The Linnean Society of London, Botanical Journal of the Linnean Society, 2011, 165, 388–401.
Engineering bio-inspired systems for the conversion of solar energy to hydrogen

With this proposal, I aim to achieve the efficient conversion of solar energy to hydrogen. The overall objective is to engineer bio-inspired systems able to convert solar energy into a separation of charges and to construct devices by coupling these systems to catalysts in order to drive sustainable and effective water oxidation and hydrogen production.

The global energy crisis requires an urgent solution, we must replace fossil fuels for a renewable energy source: Solar energy. However, the efficient and inexpensive conversion and storage of solar energy into fuel remains a fundamental challenge. Currently, solar-energy conversion devices suffer from energy losses mainly caused by disorder in the materials used. The solution to this problem is to learn from nature. In photosynthesis, the photosystem II reaction centre (PSII RC) is a pigment-protein complex able to overcome disorder and convert solar photons into a separation of charges with near 100% efficiency. Crucially, the generated charges have enough potential to drive water oxidation and hydrogen production. 

Previously, I have investigated the charge separation process in the PSII RC by a collection of spectroscopic techniques, which allowed me to formulate the design principles of photosynthetic charge separation, where coherence plays a crucial role. Here I will put these knowledge into action to design efficient and robust chromophore-protein assemblies for the collection and conversion of solar energy, employ organic chemistry and synthetic biology tools to construct these well defined and fully controllable assemblies, and apply a complete set of spectroscopic methods to investigate these engineered systems. 

Following the approach Understand, Engineer, Implement, I will create a new generation of bio-inspired devices based on abundant and biodegradable materials that will drive the transformation of solar energy and water into hydrogen, an energy-rich molecule that can be stored and transported.
Improving COmpetences and skills through Food sector InNovations

COOMON CHALLENGE:Main problem is related to innovation capacity in remote areas. In SI, HU, PL & SK those areas are facing declining employment opportunities in traditional industries as a result of structural change.This emphasizes the need to take steps to stimulate economic activity with employment generating potential for regions are facing difficulties in maintaining a critical mass of facilities to support economic development.Analysis show that FOOD SECTOR together with other value chain related sectors represent one of the most important, potential field to leverage improvement of socio-economic situation in remote areas. MAIN OBJECTIVE:Improving entrepreneurial competences and skills in remote areas through FOOD innovation potentials. OUTPUTS:1) Joint transnational food mentor scheme;2) Food crowd design platform usability. APPROACH: Project consists of 10 carefully selected competent partners who are according to the role in the project divided into 3 groups. KNOWLEDGE PARTNERS covering areas of ​​mechatronics, food safety and packing design; REGIONAL PARTNERS whose role is implementation of actions on a regional level and LEAD PARTNER who’s role is related to be engaged in all main areas of intervention together with WP coordinators. INNOVATIVE CHARACTER: (1) MENTOR SCHEME: integrated cross-sectoral experts approach (mechatronics,biotech & design), mobility of transnational pool of experts coming from different EU regions,focus oriented program to food related SMEs,sustainable business model; no similar scheme existing. (2) CROWD DESIGN PLATFORM USABILITY: unlocking food legislation restrictions, focus on food design packing and branding, open creativity,cheaper results,worldwide involvement & risk free. TRANSNATIONAL ADDED VALUE:  international pool of mobile experts, transnational partner network helping local SMEs to enter bigger market - better conditions for business expand-positive impacts on employment-braindrain stopped-tendencies to inmigration.
Probable Transmission of SARS-CoV-2 Omicron Variant in Quarantine Hotel, Hong Kong, China, November 2021

We report detection of severe acute respiratory syndrome coronavirus 2 Omicron variant (B.1.1.529) in an asymptomatic, fully vaccinated traveler in a quarantine hotel in Hong Kong, China. The Omicron variant was also detected in a fully vaccinated traveler staying in a room across the corridor from the index patient, suggesting transmission despite strict quarantine precautions.
Adhesion promoter compositions and primer compositions for metal-plastic hybrid components

The invention provides an adhesion promoter composition comprising at least one polymer A selected from at least one epoxy resin-phenol resin precondensate, a mixture of at least one epoxy resin-phenol resin precondensate and epoxy resins, a mixture of epoxy resins and phenol resins, polyamide resins and mixtures thereof, and at least one copolyamide-based hotmelt adhesive. Additionally described is a primer composition comprising at least one polymer B selected from saturated polyester resins, epoxy-phenol resin precondensates, mixtures of epoxy resins and phenol resins, and mixtures thereof, at least one crosslinker resin selected from the group consisting of melamine resins, blocked isocyanate resins and mixtures thereof, at least one catalyst, and at least one copolyamide-based hotmelt adhesive.
Sub-Nanometer quantum engineering of 2d materials for optoelectronic devices

Optoelectronic devices are at the core of today’s information revolution, bridging digital electronics and optical fiber telecommunications. However, there is a worrisome disparity in the scaling of global internet traffic (growing at 60% rate every year) and the capacity of the optical network (with growth rate of just 20%). Therefore, there is a need for new miniaturized optoelectronic technologies, and integration on silicon is a must. The objective of this project is to address this issue with a new technology for ultrafast optoelectronic components based on low-dimensional materials to achieve increased data rate and reduced footprint and power consumption. It will explore a radically new way to engineer the electrical and optical properties of these materials (specifically 2D materials and van der Waals heterostructures), to achieve, for instance, optical modulators with tunable operation wavelength and unprecedented modulation speeds and footprints. One key innovation of this approach is the use of a new gate oxide nanolamination technique able to apply a periodical electrostatic field (with sharp variations below 1 nm) on any 2D material to modify and dynamically tune their band structures. These superlattices are expected to show tunable optical properties, quantum confinement and intersubband transitions, which will pave the way to new optoelectronic components such as modulators, photodetectors, tunable lasers and light emitting diodes. This approach can be used to achieve improved coupling with polaritons in 2D materials as well, which will enhance light-matter interactions reducing the footprint of the devices. The fabrication is compatible with multiple substrate materials, including silicon and III-V semiconductors. The project will focus on large area devices operating at room temperature and integrated on silicon, to ease the subsequent implementation of this groundbreaking technology into large scale production.
Characterizing large-scale use of a direct manipulation application in the wild

Examining large-scale, long-term application use is critical to understanding how an application meets the needs of its user community. However, there have been few published analyses of long-term use of desktop applications, and none that have examined applications that support creating and modifying content using direct manipulation. In this paper, we present an analysis of 2 years of usage data from an instrumented version of the GNU Image Manipulation Program, including data from over 200 users. In the course of our analysis, we show that previous findings concerning the sparseness of command use and idiosyncrasy of users' command vocabularies extend to a new domain and interaction style. These findings motivate continued research in adaptive and mixed-initiative interfaces. We also describe the novel application of a clustering technique to characterize a user community's higher-level tasks from low-level logging data.
Growth and movement patterns of early juvenile European anchovy (Engraulis encrasicolus L.) in the Bay of Biscay based on otolith microstructure and chemistry

Various hypotheses have been put forward to explain the mechanisms in the Bay of Biscay that result in a good recruitment of European anchovy. Anchovy larvae from the spawning area in the Gironde River plume are advected towards off-shelf waters, where juveniles are commonly observed. Otolith microstructural and chemical analysis were combined to assess the importance of this off-shelf transport and to determine the relative contribution of these areas for anchovy survival. Chemical analysis of otoliths showed that anchovy juveniles in the Bay of Biscay can be divided into two groups: a group that drifts towards off-shelf waters early in their life and returns later, and a group that remains in the low salinity waters of the coastal area. The first group presents significantly faster growth rates (0.88 mm day )1 ) than those remaining in the coastal waters (0.32 mm day )1 ). This may be due to off-shelf waters being warmer in spring ⁄summer, and to the fact that the lower food concentration is compensated for by higher prey visibility. Furthermore, the group of juveniles that drifted off the spawning area and had faster growth rates represents 99% of the juvenile population. These findings support the hypothesis that anchovy in the Bay of Biscay may use off-shelf waters as a spatio-temporal loophole, suggesting that transport off the shelf may be favourable for recruitment.
Bullying behaviour, intentions and classroom ecology

Anti-bullying commitment across school communities is seen as crucial to the effectiveness of interventions. This exploratory study used a mixed-methods design to investigate bullying behaviour, intentions and aspects of the classroom ecology within the context of an anti-bullying initiative that was launched with a declaration of commitment. Across the sample of 14 primary school classes, containing 338 children aged 8–11 years, changes over time in peer-assessed and self-reported bullying and victimisation were found to be associated with changes in pupils’ sense of school belonging and perceptions of their classroom climate. Using a newly-developed theory of planned behaviour measure, changes in bullying were found to be associated with pupils’ intentions and perceived control with regard to engagement in bullying behaviour. No differences were found between intervention and comparison classes on any of the pupil outcome measures. However teachers of intervention classes reported a relative increase in perceived control over undertaking anti-bullying work with their class. The role of the class as a meaningful unit of analysis in the investigation of ecological-systemic bullying interventions in primary schools is highlighted.
EU internal security governance: the case of counter-terrorism

There are clear indicators that in spite of the sensitivity of internal security in terms of essential state functions and national sovereignty an EU governance framework with specific characteristics has emerged in the counter-terrorism field. Common threat assessments guide governance responses, and specific institutional structures, cooperation mechanisms, legal instruments, and forms of external action have been put into place to respond to the cross-border nature of the terrorist challenges. However, in line with the general subsidiary role only of the EU as provider of internal security in addition to the Member States, this governance framework remains based on the interaction and cooperation between national counter-terrorist systems and capabilities that remain largely under national control and still enjoy relatively wide margins of discretion in terms of priorities, legal framework, and organization. This analysis concludes that the EU's internal security governance – as evident from the counte...
shRNA-Mediated Silencing of Y-Box Binding Protein-1 (YB-1) Suppresses Growth of Neuroblastoma Cell SH-SY5Y In Vitro and In Vivo

Y-box binding protein-1 (YB-1), a member of cold-shock protein superfamily, has been demonstrated to be associated with tumor malignancy, and is proposed as a prognostic marker in multiple carcinomas. However, the role of YB-1 in neuroblastoma has not been well studied. To investigate the functional role of YB-1 in neuroblastoma, we established a YB-1-silenced neuroblastoma cell strain by inhibiting YB-1 expression using a shRNA knockdown approach. YB-1-silenced neuroblastoma SH-SY5Y cells exhibited a pronounced reduction in cell proliferation and an increased rate of apoptosis in vitro and in vivo xenograft tumor model. At molecular level, YB-1 silencing resulted in downregulation of Cyclin A, Cyclin D1 and Bcl-2, as well as upregulated levels of Bax, cleaved caspase-3 and cleaved PARP-1. We further demonstrated that YB-1 transcriptionally regulated Cyclin D1 expression by chromatin-immunoprecipitation and luciferase reporter assays. In addition, xenograft tumors derived from neuroblastoma SH-SY5Y cell line were treated with YB-1 shRNA plasmids by intra-tumor injection, and YB-1 targeting effectively inhibited tumor growth and induced cell death. In summary, our findings suggest that YB-1 plays a critical role in neuroblastoma development, and it may serve as a potential target for neuroblastoma therapy.
Lameness in lambs: questions around joint ill

LAMENESS has been identified as one of the major welfare problems in sheep in Britain, affecting over 90 per cent of flocks. The on-farm incidence has been estimated to be about 10 per cent (Defra 2003) and the condition negatively affects the production potential of the animal. While the major causes of lameness are footrot and scald (responsible for just over 80 per cent of cases and both involving Fusobacterium necrophorum ), there are also non-infectious causes such as post-dipping lameness and soil balling, which are significant contributors to the problem. Of course, for practitioners, it is worth remembering that lameness is often the presenting sign of foot-and-mouth disease and also bluetongue, where it is the result of inflammation of the skin above the hoof.

In Mediterranean countries, large parts of Asia (most notably Mongolia and Iran) and wherever traditional manual milking is practised, contagious agalactia, caused by Mycoplasma agalactiae , represents a major impediment to meat and milk production (Nicholas and others 2008). Arthritis is a chronic sequel to mastitis and affects lambs and ewes equally. Fortunately, there is a relatively low risk of this disease, known as the ‘shepherd's nightmare’ in areas in southern Europe where it is …
ARCHIMEDES Â BECOMES THE NEW DESIGN AND LIFE MANAGEMENT ENVIRONMENT OF A MEANS OF TRANSPORT IN THE NAUTICAL SECTOR TO REDUCE COSTS AND ENVIRONMENTAL IMPACTS.

THIS IS THE PROBLEM OF THE CURRENT DESIGN AND CONSTRUCTION OF A HIGHLY COMPLEX SYSTEM SUCH AS THIS WOULD REQUIRE THE USE OF MANY HETEROGENEOUS DESIGN TOOLS (CAD, PLM, EGF, ETC.) AND THE NEED FOR SEVERAL PLAYERS TO CONFRONT A COMMON MODEL. TO DATE, THE USE OF THESE TOOLS IS BECOMING COMMONPLACE FOR THE DESIGN DEPARTMENTS, BUT THEIR REAL ACTIVITIES ARE NOT BEING FULLY EXPLOITED, AS THE DIFFERENTIATION OF SOLUTIONS OFFERED BY THE MARKET MAKES THE PROCESS OF DIALOGUE AND THE MANAGEMENT OF THE WORKFLOWS COMPLEX.  IN ADDITION, THESE INSTRUMENTS MAINLY ALLOW FOR THE CREATION OF A GEOMETRIC MODEL OF THE PRODUCT ITSELF AND THE POSSIBLE IMPACTS OF THE DESIGN OF THE CRAFT OVER THE USEFUL LIFE OF THE VESSEL ITSELF. AS YOU ARE AWARE, THESE ASSETS ARE DESIGNED TO LAST FOR 20 YEARS AND THE CHOICES MADE IN THE CONCEPTUAL PHASES HAVE A DOMINANT EFFECT.