SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Life-Inspired complex molecular systems controlled by enzymatic reaction networks

Many of the key functions typically associated with living systems, including sensing of the environment, autonomous decision making, and extracting energy and building blocks from the environment for cell growth and division, are all governed by enzymatic reaction networks. Constructing synthetic systems that capture some of these capabilities, i.e. life-inspired systems, would represent a truly disruptive development, as they challenge our notion of what differentiates living systems from synthetic, man-made devices. However, the ability create synthetic life-inspired systems remains an elusive goal. Despite impressive progress in systems chemistry, no clear engineering principles or methodologies exist for the bottom-up construction of functional complex molecular systems The translation of the design principles of living systems into programmable and functional life-inspired systems is one of the outstanding grand challenge in chemistry. The ultimate aim of this proposal is to construct life-inspired systems based on the design blueprints of living matter  To achieve this aim,  I propose a key breakthrough by presenting a completely new approach to functional complex systems based on programmable enzymatic reactions networks. The envisaged approach is modular and will allow for systematic increases in complexity. The core objectives of this proposal are:  - establish a completely new approach to programmable enzymatic reaction networks - compartmentalize network motifs, and separate the small molecule ‘software’ from the enzyme ‘hardware’  - demonstrate modularity and increase the complexity via communication between compartments - develop robust methods to manage the maintenance of non-equilibrium conditions - design and construct complex life-inspired systems.
MEDiterranean QUadruple helix Approach to Digitalisation

Innovation and technology are recognised as a major driver for competitiveness and for long-run endogenous economic growth. However, most of Mediterranean regions are characterised by a high prevalence of micro enterprises, with difficulties to acquire the necessary skills to innovate and grow. MED-QUAD will address this challenge through the cooperation among universities in 6 countries. The project aims to nurture the innovation potential of the regions, by building up a cross- border cooperation scheme of the Quadruple Innovation Helix. The main actors are the universities which will improve their capacity to be and act as “civic universities” in cooperation with the cities to which they belong as “anchor” Institutions together with the socio-economic stakeholders and the citizens. Two cross-border Living Labs will be established in the cities, where several pilot activities for technological transfer and commercialisation of research results will be implemented. They will exploit ICT technologies and Key Enabling Technologies for water use optimization, consumption and reduction (Smart Water Use Applications - SWUAP), as well as cultural heritage promotion and preservation (Applied Research for Cultural Heritage Exploitation - ARCHEO). The project will set up a toolkit for enhancing the institutional capacities of businesses, cities and universities of both shores of the Mediterranean to work together and reinforce their role as “catalysts” for fair and inclusive development.
PROGRAMMA A SOSTEGNO DELLA DEFINIZIONE DELLA STRATEGIA DI INTERNAZIONALIZZAZIONE E DELL'APPROCCIO AI MERCATI PRIORITARI PER LE RISORSE ENDOGENE E I PRODOTTI TURISTICI PROVENIENTI DALLA TERRAFERMA

CIM TTM (capoprogetto), in co-promozione con AMTQT e AMTFNT, promuove il Programma per sostenere la definizione della strategia di internazionalizzazione e l'approccio ai mercati prioritari per le risorse endogene e i prodotti turistici della Terras de Trás-os-Montes, con l'obiettivo di aumentarne la competitività e la progressione nella catena del valore, nonché di migliorare la visibilità internazionale della regione.
High temperature methanol fuel cell

The German company Siqens has developed a High Temperature Methanol Fuel Cell (HT-MFC) with outstanding technical and economical characteristics. The first product will be an eco-friendly and affordable system named EcoPort for the camping and boat market. EcoPort generates electrical power using renewable methanol liquid fuel. The Danish company Danish Power Systems manufactures the key fuel cell component, the MEA (Membrane Electrode Assembly), for the Siquens products. The project aim sets a significant basis for the efficient and effective transformation of chemical energy from the substance methanol into “clean” (carbon neutral) electrical energy.  The fuel cell from Siquens allows an expanded use of electricity from renewable energies. The production of methanol from wind and sun by Carbon Capture Utilization (CCU) methods is a great chance to store energy of renewables allowing to reach the individual climate goal of the German government (80% renewables in 2050). The ecological benefits of our solution makes it a valuable contribution to the EU climate goals. The market in 2018 for the 800 Watt variant (EcoPort800) is expected to be 930 units with a delivery price of 5,000 EUR each, generating a turnover of more than 4.6 million Euros. In the present project the components and final products need to be finally developed and manufactured with lower costs.
Néologismes en discours spécialisé. Analyse comparée des noms de stades de football dans quatre pays europeens

The present contribution intends to innovate in neology and onomastic analysis, by relying on an empirical study of soccer stadium names in France, Germany, England and Spain, in order to validate on corpus a holistic, discursive, cognitive, and interdisciplinary approach of neology. For this purpose, we will establish a theoretical framework, based on the recognition of the limits of formal models of neology, in order to integrate discursive variables, and also to capture the totality of the social mechanisms governing the displayed use of linguistic structures. These structures are characterized by non-compositionality and specialized informational linearization. In fact, the soccer stadium names, result of the naming process, related to the commodification of the soccer sector, deploy a new neologic structure such as &lt;[SPONSOR]+ [GENERIC TOPONYM]&gt;, which gives birth to results such as Allianz Arena or Emirates Stadium. This analysis of stadium names is part of a larger project focused on specialized discourses. La présente contribution entend innover dans l’analyse néologique et onomastique, en partant d’une étude empirique de noms de stades de football en France, Allemagne, Angleterre et Espagne, pour valider sur corpus une approche holistique, discursive, cognitive et interdisciplinaire de la néologie. En effet, à cette fin, nous déployons un cadre théorique reposant sur la reconnaissance des limites des modèles formels de néologie, afin d’intégrer les variables discursives, dans le but saisir la totalité des mécanismes sociaux régissant l’usage attesté de structures linguistiques. Lesdites structures se caractérisent par une non-compositionnalité et une linéarisation informationnelle spécialisée. En effet, les noms de stade, issus du processus de naming, relatif à la commodification du secteur du football, déploient un schéma néologique nouveau tel que &lt;[SPONSOR]+[TOPONYME GENERIQUE]&gt;, permettant de générer des réalisations, tels que Allianz Arena ou Emirates Stadium. Cette analyse des noms de stade s’insère dans un projet plus vaste d’étude des discours de spécialité. ras
(14508.17092020.172000365) OROKAPPA EVOLUTION

PURCHASE LASER SYSTEM MARKING PRECIOUS METAL OBJECTS INCLUDING PERSONAL COMPUTER WITH MONITOR AND DEDICATED SOFTWARE. BUY TRANCHES PUNCHES DIES AND COUNTER-MOLDING.
Resuscitation with whole body cooling prevents multiple organ damage after hemorrhagic shock in rats

Whole body cooling (WBC) has been shown to improve survival in hemorrhagic shock (HS) rat studies. We hypothesized that induction of WBC would be beneficial for multiple organ damage (MOD) during HS resuscitation. Light anesthesia was induced with ketamine in rats, and spontaneous breathing was maintained. Rectal temperature (Tr) was monitored at about 36oC. HS was induced by blood withdrawal of 6ml/100g body weight during a 60-minute period, following by blood transfusion for a 30-minute period. Immediately after blood transfusion, rats were randomized into three groups of 10 rats each: group 1, untreated HS rats maintained at Tr 36.5oC; group 2, HS rats maintained to Tr 37.5oC (with 36oC water blanket temperature); and group 3, HS rats maintained to Tr 34oC (with 16oC water blanket temperature). Rats were controlled at each target Tr for 30 min. It was found that resuscitation with blood, but not WBC, induced significant multiple organ dysfunction, manifested by a high plasma level of aspartate aminotransferase, alanine aminotransferase, blood urea nitrogen, creatinine, and lactate dehydrogenase. In addition, HS rats received blood transfusion alone has significant MOD, evidenced by a high score of lung, kidney, or liver. The MOD caused by HS were significantly attenuated by WBC, in particular with the 16oC WBC. Our data indicate that resuscitation with WBC prevents multiple organ dysfunction or damage after acute HS in rats.
Efficient, flexible synthesis of molecules with tailored shapes: from photo-switchable helices to anti-cancer compounds

The creation of new molecular entities and subsequent exploitation of their properties is central to a broad spectrum of research disciplines from medicine to materials but progress has been limited by the difficulties associated with chemical synthesis. We are now proposing a fundamentally new strategy, which has the potential to revolutionise how we conduct complex organic synthesis. The basic C–C bond-forming step involves the reaction of a lithiated carbamate with a boronic ester to give a homologated boronic ester with complete stereocontrol. Furthermore, the reaction shows >98% efficiency in most cases and can be conducted iteratively and in one pot (up to 9 iterations has been demonstrated with full stereocontrol). We will now extend this methodology to more functionalised carbamates as this will enable the rapid synthesis of polypropionates, which are amongst the most important classes of biologically active molecules. The robust methodology is now ripe for transfer to the solid phase as this will enable the preparation of libraries of these molecules. Through applying our assembly-line-synthesis methodology to complex molecules with diverse structures, we will demonstrate its scope, robustness, and full potential. The methodology enables stereochemistry to be ‘dialled in’ to a carbon chain, which in turn controls the conformation and we will exploit this feature in the shape-selective synthesis of molecules. We will explore how the sense of helical chirality of these molecules can be switched (M to P) just with light. We will target helical molecules with specific groups at specific places for optimum binding to disrupt protein–protein interactions involved in cancer. Finally, our methodology provides ready access to a family of building blocks that represent common repeat units found in polyketides. By combining these building blocks iteratively using lithiation-borylation, we should be able to rapidly and reliably prepare complex natural products.
Panel filled with polymeric foam

The transparent plastics plates have wide chambers filled with a plastics foam of high transparency of a value greater than 30%. The plates are shaped from thermoplastic material. The width of the individual chambers should be pref. between 300 and 500 mm. The plates can be extruded.
MEDICAL GRIPPING INSTRUMENT AND METHOD FOR USING THIS MEDICAL GRIPPING INSTRUMENT

The invention relates to a medical gripping instrument, especially for use in microlaryngoscopy, comprising a longitudinal extended shaft (2) on whose distal end a pincer part (3) is arranged which can be moved between a closed and an opened position. A handle (5) consisting of a fixed handle part (6a) and of a handle part (6b) that can pivot in relation to the fixed handle part (6a) is arranged on the proximal end of said shaft. The pincer part (3) is moved via a push/pull rod (8) which is mounted in the shaft (2) and which is connected to the pivotal handle part (6b). The gripping instrument also comprises a spreading part (4) which can be tilted from the shaft (2). The aim of the invention is to create a gripping instrument of the aforementioned type which, in addition to having a simple construction and being easy to manipulate, ensures the protection of the tissue that is to be treated with care. To this end, the invention provides that the spreading part (4) which can be tilted from the shaft (2) is, in addition to the pincer part (3), arranged on the distal end of the shaft (2) and can be tilted from the shaft (2) within a plane in a manner that is approximately perpendicular to the plane of movement of the pincer part (3).
The Effect of Tamoxifen Treatment During 24 Months On Alkaline Phosphatase Concentration In Breast Cancer Patients

Determination of alkaline phosphatase (ALP) isoenzyme activity is useful for the diagnosis and clinical evaluation of cancer patients, including breast cancer. 21 women were randomized to receive tamoxifen , probably the most widely used endocrine treatment for breast cancer worldwide, for 2 years, and 21 women constituted the control group. Control group were treated without Tamoxifen considering placebo effect. Alkaline phosphatase level was significantly lower in tamoxifen treated female breast cancer patients when compared with those of the treated patients with placebo. Results indicates that the tamoxifen decrease the level of ALP in first three months and then stabilize this level in the following months.
An Application of Dichotomous Induction Technology in WTP Estimate and Deviation Analysis for Coastal Resource Protection in the Guangxi Beibu Gulf Economic Zone

Using dichotomous induction technology we estimated the willingness to pay(WTP) for ecological environmental protection or restoration in four coastal cities of the Guangxi Beibu Gulf Economic Zone. The influential factors of deviation in WTP choices were also analyzed. According to a questionnaire survey of 940 people we found that citizens' WTP in the four coastal cities is estimated at 204.13~450.17 CNY per person per year in the next five years to recover or protect the good ecological environment in local coastal areas,and the total economic value is 2.56~5.65×109CNY a year. The expected WTP value in a single boundary is higher than that in the multi-boundary;both are higher than the simple arithmetic mean value. Given that the latter excludes other variables,it is considered that it will reduce underestimate bias to arrive at the WTP expected value in both the single and multi-boundary as the intervals of WTP value. To avoid a framework anchoring effect error,the questionnaire is not designed as a single dichotomous questionnaire,but adds items of payment card bid value. The results show that highest bid value chosen by respondents is within the intervals of the presupposed bid value in dichotomous questions,which indicates that the presupposed value bid is reasonable without obvious framework anchoring effects. The respondents have high satisfaction regarding living conditions, environmental policy and economic income. Their willingness to pay is higher than those who have lower satisfaction and the reason may be because of protest bias.
Implementación de un sistema de contabilidad de costos en la empresa florícola Spacium s.a. ubicada en la parroquia Mulalillo, cantón Salcedo, provincia de Cotopaxi, al periodo del 1 de agosto al 31 de diciembre del 2013

At the present, for enterprises to have a good cost system is to possess a competitive advantage against other, since, it helps the management to better decision-making according with the principles and organization of the modern management. Therefore, is made the present thesis in order to implement a costs system based in activities in the Floriculture SPACIUM S.A., since knowing the real costs of the products; it is essential to define which activities are carried out into the enterprise, how many do they cost the same, why do they need to make them. Identifying relevant activities and assigning indirect costs to each activity in proportion to the resources use, identifying inducers of appropriate costs for each activity and assigning the indirect costs to products, the selves are an economic map of the costs and profitability in based to the activities, to achieve this aims testing all documents and information facilitated by the departments of the enterprise which provided the most precise information about the cost of the activities required to produce roses, accounting system of costs based on designed activities; it is generated according the needs of the enterprise which will allow to make decisions that optimatize developed activities in the productive processes as the activity-based system costing can identify the activities what create value and unnecessary costs, assisting as important point the resources optimization and profits increase and achieving business success.
A Comprehensive Review on the Errors That occur during Ideal Teeth Arrangement for Complete Denture Prosthesis

The aim of this article is to present a comprehensive review and a classification system on the various errors that occur during the ideal arrangement of artificial teeth for complete denture prosthesis.Assessment of various classification systems presented for errors in artificial tooth arrangement and identifying the lacunae in each system.A comprehensive review and a classification system on the various errors that occur during the ideal arrangement of artificial teeth for complete denture prosthesis have been presented.This classification system is aimed toward dental students and dental practitioners to aid in the arrangement of artificial teeth for complete denture prosthesis.The proposed classification system helps the operator to identify the various errors which may occur during the arrangement of artificial teeth for complete denture prosthesis. It also aids in providing a detailed insight into the role played by artificial teeth in restoring the form and function of completely edentulous patients.
Endonaut delivery platform

Translating intracellular delivery to the market
The advent of nanotechnology allowed the combination of new chemical and physical tools to engineer carriers able to perform specific functions at the molecular level. 
In recent years the ERC award ERC-STG-MEViC, helped to develop a powerful new technology called EndoNaut. This can be used to encapsulate and deliver dyes, imaging and contrast agents and drugs. EndoNaut technology consists of pH sensitive polymeric vesicles with the unique characteristics of endosomal delivery whilst maintaining cell viability and metabolic activity. The core technology, is based on the assembly in water of diblock copolymer poly(2-(methacryloyloxy)ethyl phosphorylcholine)–poly(2-(di-isopropylamino)ethyl methacrylate) (PMPC–PDPA) into vesicles (also known as polymersomes). These nanoscopic carriers enable the encapsulation of both hydrophilic and hydrophobic compounds including large biological macromolecules. Intracellular delivery is of prime importance for several applications and it can enhance existing therapies as well as allowing new ones. It is not surprising that EndoNaut  is now generating significant commercial interest from several our collaborating pharmaceutical and non-pharmaceutical partners.
There are two major areas of application for EndoNaut that offer opportunity for short term commercialisation. The first application is as a reagent in life science research and the second is as screening platform for new chemical entities libraries of pharmaceutical companies with few or no other option to deliver their molecules.  The world market for both intracellular reagents and high-throughput screening are predicted to grow yearly by 8-9% generating revenue in the order of billions of USD (PRNewswire). The aim of this project is to form a new company dedicated to the exploitation of EndoNaut technology. The current grant would be enabling in the translation process from laboratory to market.
BIOACTIVE-RICH CONCENTRATES AND NUTRITIVE AND THERAPEUTIC PRODUCTS CONTAINING SAME

This invention relates generally to the field of compositions for use as nutraceuticals, food additives or adjuncts to conventional drug therapies. In particular, the invention relates to compositions derived from natural oil sources, the unsaponif iable content of an oil of rice bran or rice germ which can be used for effective and inexpensive treatment of cardiovascular diseases, hypercholesterolemia, diabetes, cerebrovascular disease, neurological disorders, or liver abnormalities.
SYSTEM, METHOD, AND DEVICE FOR ANALYZING GAME PLAY VIDEO

A computer implemented system and method for analyzing gameplay files to provide a training assessment. The system includes an input module to receive a raw replay file from a game, game platform, or user and provide the raw replay file to a parsing module. The parsing module is configured to parse each raw replay file and classify the parsed replay file as any event type indicated by feature data of the parsed replay file. Where the parsed replay file is classified as at least one event type, the parsing module saves the parsed replay file in an event dataset. The parsing module extracts game events from the parsed replay file and saves the game events in an event table schema. The input module may be integrated into a backend of a game or a game platform. The system may include a training assessment module configured to generate the training assessment.
Dynamic origins of mhc class i selector function

DynOMIS aims to elucidate the antigen selection mechanisms of the adaptive immune system at the molecular level in the highly complex cellular environment. Major histocompatibility complex class I molecules (MHC-I) is a key mediator of adaptive immunity, the cell’s arsenal against infectious pathogens and malignant transformations. MHC-I present antigenic peptides to cytotoxic T lymphocytes at the cell surface, which in turn unleash their cytotoxic apparatus only when peptides from non-healthy proteins are recognized.  This process is the result of an equally important peptide selecting function in the early secretory pathway, a mechanism that has not been clearly understood in spite of its fundamental role in vaccination. Deep understanding of the exact mechanisms that drive peptide selection by MHC-I will help to predict immunoprotective epitopes in infections and cancer, which will in turn pave the way for the development of more effective T cell-targeting vaccines and biomarkers to stratify patients’ suitability for immunotherapy.
DynOMIS will employ a sophisticated, interdisciplinary approach that integrates quantitative computational systems modelling to identify molecular mechanism from cellular biochemical information, experimental investigation of the structure and dynamics of peptide-bound MHC-I over a large range of timescales, and state-of-the-art molecular dynamics simulations and free energy calculations to elucidate the thermodynamic basis of the peptide selection mechanism in the context of their interactions with cellular cofactors. To this end, DynOMIS will be carried out by an experienced researcher at a world-leading interdisciplinary group comprising molecular immunologists, structural biologists, computational chemists, and industrial partners with a strong focus on clinically relevant immunological research.