SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Increased Mitochondrial DNA in an ECMO Model Is Associated with Loss of Platelet Function

Abstract Background Extracorporeal Membrane Oxygenation (ECMO) represents a promising technology for resuscitating trauma patients with severe lung and/or cardiac injury. Common ECMO-related complications of thrombosis and bleeding result in significant rates of mortality and morbidity. Multiple studies with ex-vivo ECMO devices using blood demonstrate an increased proinflammatory response. Mitochondrial DNA (mtDNA) is a known damage associated molecular pattern (DAMP) that has been shown to have proinflammatory effects. Recent studies have correlated poor clinical outcomes to increased levels of plasma mtDNA. The objective of this study was to determine the levels of mtDNA in an ECMO model as a function of shear stress and duration of pump flow and evaluate the possible impact of mtDNA on platelet function. Methods Blood was collected from healthy donors under a US Army Institute of Surgical Research approved standard operating procedure. We constructed an ex-vivo ECMO circuit that circulates heparinized human blood for six hours at differing flow rates (static control-0 L/min, 0.3, and 0.7 L/min). Quantification of mtDNA and assays of platelet function were performed on samples obtained from each group and were compared to static controls at 0, 60, 120, 240, and 360 min. mtDNA levels were assayed by measuring the copy number of the NADH dehydrogenase 1 gene using quantitative real-time PCR. Additional tests were performed on platelet count, aggregation, viability (as measured by calcein/CD41a), TEG, and Multiplate. Results Increased flow rates and duration resulted in significantly higher levels of plasma mtDNA compared to static controls (static control, 0 L/min flow rate: 120 min = 3 x 105 ± 1.8 x 105, 240 min = 4 x 105 ± 2 x 105 copies/µL; 0.3 L/min flow rate: 0 min = 4 x 105 ± 0.8 x 105, 120 min = 8 x 105± 0.2 x 105, 240 min = 8 x 105 ± 1.6 x 105 copies/µL; 0.7 L/min flow rate: 0 min = 3 x 105 ± 0.9x 105, 120 min = 19 x 105± 4 x 105, 240 min = 35 x 105 ± 6 x 105 copies/µL; p Conclusions Increased mtDNA in surgical patients has been linked to poor outcomes. It has recently been shown that circulating mtDNA can trigger the innate immune system through toll-like receptor 9 (TLR9) and NF-κB activation, causing deleterious effects. In this study we found that mtDNA levels significantly increase as a function of shear stress and increased duration of pump flow. These increases were shown to be associated with loss in platelet function in both TEG and Multiplate measures of ADP and collagen agonist stimulated responses. Future ECMO studies will explore the correlation between circulating mtDNA levels and TLR9. mtDNA may be a clinically relevant biomarker and therapeutic target for efforts to mitigate life-threatening ECMO coagulation complications. Download : Download high-res image (98KB) Download : Download full-size image Disclosures No relevant conflicts of interest to declare.
Correlated hybridization induced super-Poissonian noise in quantum dots

Transport through molecules or quantum dots is sensitive to not only the localized interactions on the conductor but also the hybridization to the external leads. In this study, we investigate the noise properties of a single level quantum dot with correlated hybridizations to the leads. In contrast to the featureless dot-lead coupling used in previous studies, we show that the correlated hybridization can give rise to the electron bunching in the transport. As a result, the noise Fano factor may be enhanced to super-Poissonian when the tunneling strength depends strongly on the electron number on the dot. This super-Poissonian noise appears at high bias voltage which enables the transfer of electrons via the doubly occupied state.
Impact Assessment on Land Acquisition of Transmission Line Development toward Socioeconomic Conditions of Society

Development of transmission line is needed to increase the availability of electrical demand. This development requires a land acquisition, which has some impacts toward socio-economic of society, namely changes of livehood and loss of earnings. Objectives of this study were: 1) to identify some problems caused by land acquisition; 2) to analyze the changes of livehood and income caused by land acquisition; 3) factors affected price of land compensation; 4) alternatives solution to minimize impact of land acquisition. The change of livehood was analyzed by descriptive qualitative method, meanwhile the change of income by loss of earning, factors affected price of land compensation by regression. This study was conducted in 12 villages in Bogor and Depok crossed by the transmission line. The result of study showed that the transmission lines development the emergencing of various problems, namely: (a) land acquisition is causing the loss of home for 3,33 percent of respondents that had to be relocated to other areas, (b) land acquisition is causing the loss of 16,63 percent agricultural land owned by community that affected by the transmission line, (c) land acquisition is causing internal conflict within the family of 5.00 percent respondents in terms of the distribution of compensation money received. The land acquisition causes change of livelihood of farmers (6,67 percent), owners of grocery shop and drink stalls business (3.33 percent), and business owners of rental house (3,33 percent). This causes loss of earning for 26.67 percent respondent, with the total loss of earnings of IDR 6,605,000 per month or an average of IDR 412,813 per month per respondent. The regression model of land compensation price has R-Square (adj) 73,9 percent, with the factors that significantly affect the value of land compensation are: Tax Object Sales Value (NJOP) of land, market price of the land, and the size area of respondents landholding, with a significance level of each respectively 0,000. The result of classical assumption test proves that the regression model is built in accordance with the rules of econometrics is good with no autocorrelation, no multicollinieraty, no heteroscedasticity, and the data is also distributed normally. To minimize the land acquisitioned impact should be noted about how the continuation of economic enterprise communities that rely on land as the main capital of the business, and how the compensation value specified must meet the aspect of obedience to the law and agreement with the land owners.
VERTEBRAL CONSTRUCT AND METHODS OF USE

A vertebral construct comprises a longitudinal element extending between a first end and a second end. The longitudinal element defines a central axis. A first spacer is mounted to the longitudinal element. A second spacer is mounted to the longitudinal element. A flexible element is disposed about the longitudinal element and between the first spacer and the second spacer. The flexible element defines a central axis offset from the central axis of the longitudinal element. Methods of use are disclosed.
Enabling chemical propulsion system for the growing small satellite market

The global satellite industry is experiencing a paradigm shift exhibited by the rapid expansion of the small satellite market. It is being driven by continuously advancing technological, design, manufacturing capabilities and decreasing launch costs.
Despite the booming demand for and evident advantages of small satellites, one critical system – satellite propulsion – have fallen behind this recent miniaturization trend. At present, there are no market-ready small satellite green chemical propulsion systems available. Alternative propulsion systems are mostly based on hazardous chemicals, are expensive, difficult to integrate and offer low performance.
NanoAvionics, a satellite manufacturer and integrator, developed EPSS (TRL 6) – low cost, high performance propulsion system for small satellites, making use of a non-toxic, environmentally-friendly propellant. The entry market size for this system is €1.75 bn in 2017-2020. Success in this market will permit later extension of the technology to the medium and large scale satellite market.
To ensure successful commercialization, during SME Phase 2 project NanoAvionics aims to conduct final piloting and qualification of the technology, preparation of the production infrastructure, product commercialization, and increasing the investment readiness of the company. The project will raise the TRL of EPSS to 8 by integrating it into pilot partner’s satellite, and will contribute to reaching TRL 9 by launching partner’s satellites to space demonstrating EPSS in orbit. Using EPSS will enable pilot partner to offer unique services based on small satellite constellations.
NanoAvionics has already signed the piloting agreement as well as 3 Memorandums of Understanding and 10 Letters of Intent with organizations that intend to integrate EPSS into their satellites. SME Phase 2 project will result in €14 M revenues and €4.4 M profit by 2020 and brake even reached in 2 years after the end of the project.
FORMATION TESTER COMPRISING REACTIVE FILTER MATERIAL

The embodiments herein relate to formation testers having reactive filter materials for detecting analytes in subterranean formation operations. The formation include a body having an outlet, a probe extendable from the body and having a sealing pad and a probe snorkel tube, a flow line within the body, wherein the flow line has an entry end connectable to the probe snorkel tube and an exit end connectable to the outlet in the body, a sample chamber fluidically connectable to the flow line downstream of the entry end of the flow line, and a reactive filter material in the flow line downstream of the sample chamber. The reactive filter material sorbs an analyte in a wellbore fluid.
Drilling in supercritical geothermal condition

The aim of the “Drilling in dEep, Super-CRitical AMBients of continentaL Europe: DESCRAMBLE"" project is to develop novel drilling technologies for a proof-of-concept test of reaching deep geothermal resources and to contribute to a low-carbon European society. To achieve this target the first drilling in the world in an intra-continental site at a middle-crustal level will be performed. The test site is an existing dry well in Larderello, Italy, already drilled to a depth of 2.2 km and temperature of 350 °C, which will be further drilled to 3-3.5 km to reach super-critical conditions unexpectedly experienced, and not controlled, in a nearby well in 1979. 
The project will be organized into two main phases: (1) Drilling in super-critical conditions, including drilling components, well materials, design and control; (2) Geo-Scientific activities for predicting and controlling critical conditions, which considers petrological, physical and chemical characterization, simulation and monitoring, including high temperature and pressure tools.
Main expected outcomes:
• Improved drilling concepts in deep crustal conditions
• New drilling materials, equipment and tools
• Physical and chemical characterization of deep crustal fluids and rocks
The site is perfect for such an experiment, as it is representative of most deep crustal levels in Europe, cost effective since drilling to reach the target is reduced to a minimum, practical due to the high probability of encountering super-critical conditions. The productivity and efficiency of the project are guaranteed by the combination of industrial and research participation and by the recognised expertise of the consortium in geothermal R&D as well as oil and gas drilling, bringing together excellence in the respective sectors. 
DESCRAMBLE will explore the possibility of reaching extremely high specific productivity per well, up to ten times the standard productivity, with a closed loop, zero emission, and reduced land occupation.
SINGLE-LAYER MULTI-STRAND CABLE HAVING IMPROVED ENERGY AT BREAK AND AN IMPROVED TOTAL ELONGATION

The invention relates to a multi-strand cable (50) having a 1xN structure comprising a single layer (52) of N strands (54) that are helically wound about a main axis (A), each strand (54) consisting of a layer (56) of metal wires (F1) and comprising M>1 metal wires that are helically wound about an axis (B). The cable (50) has a total elongation At > 8.10%, and the energy-at-break index Er = rAt of the cable (50) is defined as Er = ∫ AT σ(Αί) x dAi, where σ(Αί) is the tensile stress in MPa measured at the elongation Ai, and dAi is the elongation such that Er is strictly greater than 52 MJ/m3.
COLD SEAL GLASS BLOCK UTILIZING INSULATING MATERIALS

A glass block including an insulating material disposed with an interior chamber. The block includes a first block half, a second block half, and a frame. The frame is positioned between and aligns the first block half and the second block half so that the block halves and the frame define a complete enclosure. The frame holds at least two partitions inside the block. The partitions divide the interior of the block into a plurality of chambers including at least one interior chamber disposed between the partitions. An insulating material is disposed in the interior chamber between the partitions.
The relationship between executive functions and fluid intelligence in schizophrenia

An enduring question is unity vs. separability of executive deficits resulting from impaired frontal lobe function. In previous studies, we have asked how executive deficits link to a conventional measure of fluid intelligence, obtained either by standard tests of novel problem-solving, or by averaging performance in a battery of novel tasks. For some classical executive tasks, such as the Wisconsin Card Sorting Test (WCST), Verbal Fluency, and Trail Making Test B (TMTB), frontal deficits are entirely explained by fluid intelligence. However, on a second set of executive tasks, including tests of multitasking and decision making, deficits exceed those predicted by fluid intelligence loss. In this paper we discuss how these results shed light on the diverse clinical phenomenology observed in frontal dysfunction, and present new data on a group of 15 schizophrenic patients and 14 controls. Subjects were assessed with a range of executive tests and with a general cognitive battery used to derive a measure of fluid intelligence. Group performance was compared and fluid intelligence was introduced as a covariate. In line with our previous results, significant patient-control differences in classical executive tests were removed when fluid intelligence was introduced as a covariate. However, for tests of multitasking and decision making, deficits remained. We relate our findings to those of previous factor analytic studies describing a single principal component, which accounts for much of the variance of schizophrenic patients' cognitive performance. We propose that this general factor reflects low fluid intelligence capacity, which accounts for much but not all cognitive impairment in this patient group. Partialling out the general effects of fluid intelligence, we propose, may clarify the role of additional, more specific cognitive impairments in conditions such as schizophrenia.
Basic Violet Decolourization Using Alginate Immobilized Nanozirconium Tungestovanadate Matrix as Cation Exchanger

As an innovative cation exchange material, nanozirconium tungestovanadate prepared using homogeneous precipitation technique was immobilized into alginate matrix and evaluated for cationic dye decolourization. Physicochemical properties of the prepared composite material were examined to determine its crystallinity, morphology, and ion exchange capacity. The SEM and TEM images of the prepared zirconium tungestovanadate identified that it was prepared in homogeneous structure with spherical shape in average diameter 22 nm. However, the optical microscope image of the composite matrix confirms the good distribution of nanozirconium tungestovanadate into the polymeric matrix. Batch technique was utilized to test the cation exchange efficiency of the prepared composite material toward C.I. basic violet 16 dye decolourization. The optimum immobilized dosage from nanozirconium tungestovanadate into the polymeric matrix to achieve 99% dye decolourization from 50 ppm initial dye concentration was recorded as 8 g/L. The dye sorption process onto the prepared material is described as an endothermic process. The dye sorption process at equilibrium was following both Langmuir and Freundlich isotherm models. The kinetic sorption behaviour of dye onto the composite matrix is correlated to pseudo-second-order equation model.
Structured approaches for forest fire emergencies in resilient societies

Forest fires are exacerbated by extreme weather conditions, which are increasing both in frequency and in magnitude due to climate change effects. This points to the need for improving the effectiveness of emergency management solutions aimed to help society in becoming more resilient to emergencies arising before, during and after forest fire events. Therefore, it is proposed to realize a comprehensive Emergency Management System (EMS) that we name SAFERS: Structured Approaches for Forest fire Emergencies in Resilient Societies. SAFERS will act along the key phases of the emergency management cycle, coupling information from EO data and services offered by Copernicus and GEOSS, crowdsourced data from social media and from specific applications that can be used by both citizens as well as from in-field professional agents, data generated by accurate sensors to detect smoke or fires. Advanced algorithm based on Artificial Intelligence will be used to generate risk maps and early warnings in the preparedness phase, estimate the forest fire extension and its propagation in function of the forecasted weather and soil conditions in the response phase, compute the impacts of an extinguished fire in terms of economic losses and monitor the soil recovery in the post-event phase.
Scaling the ISAM Land Surface Model through Parallelization of Inter-component Data Transfer

We present the progression of developments necessary to scale the ISAM landsurface model from single nodes and small clusters with unusually largeper-node memory to much larger systems with more common configurations. These efforts include load balancing, conventional library-based output parallelization to reduce memory load, and parallel-in-time data input. On Hopper, a Cray XE6 machine, the result was strong scaling from 256 cores to 16k coreswith an efficiency of 32.9%. On Edison, a Cray XC30 machine, the code strong scales from 256 cores to 16k cores with an efficiency of 51.4%. These large-scale gains, and the associated performance increases at smaller scale, enable greater scientific productivity for the users of ISAM and open the possibilities of increased resolution in time and space and greater physical fidelity for the simulated processes while remaining computationally feasible.
Eco-marketing to promote Eco-industrial Parks

ECOMARK wants to develop a GREEN MARKETING, specifically for Eco Industrial Parks (EIP) and generally for Industrial Areas (IA), with the aim of favouring the competitiveness of SMEs and a more sustainable community development. The Green Marketing principle is based on sustainable (Green) products, processes and services, and is oriented towards the external communication. Green Marketing is already an affirmed opportunity for innovation, but has not yet been applied to IAs. We consider that the Green Marketing principle can provide innovation related to goods mobility & logistics, energy supply and use, water cycle optimisation, a more sustainable waste management and as a follow up better Information and Communication (IC) networks. The main outputs will be guidelines for Green Marketing Plans (GMP), schemes for innovative services and demonstration of a reduced environmental impact induced by IAs on the local community. The GMP will be strongly market oriented.
Special Issue on Globalization, Cosmopolitanism, and Migration: Ethics of Inclusion and Exclusion

The contributors to this issue offer applied critical and normative perspectives on central, yet overlooked, ethical aspects of migration management with a certain cosmopolitan lance in some capacity. However, cosmopolitanism might mean different things for transnational migration. It can refer to “political cosmopolitanism” that provides the reasons for why there should be certain global institutions governing migration. It can also refer to “moral cosmopolitanism” that simply represents a moral concern for individual rights and interests first and foremost (Caney 2005). Cosmopolitanism can also work as a lens that is based on a scepticism towards using the nation-state as the ultimate unit or locus of analysis. These perspectives are not mutually exclusive, and the contributions in this special issue accommodate a form of cosmopolitan outlook or stance to some extent in their discussion on migration management practices.
An enhanced location-free Greedy Forward algorithm with hole bypass capability in wireless sensor networks

Greedy Forward is a technique for data routing in Wireless Sensor Networks (WSNs) in which data packets are forwarded to the node that is geographically closer to the destination node. Two main concerns can be found in routing algorithms based on this technique: first, it requires all sensor nodes to know their physical location. Second, this kind of algorithm does not work in cases when a node is located in a network 'hole', i.e., the node does not have any neighbor closer to the destination node. In this work, we propose a new Greedy Forward algorithm that can be used in routing protocols for WSNs that does not require localization of the nodes and also is able to deal with nodes located near network holes. Differently from current greedy forward algorithms, our approach uses only the Received Signal Strength Indicator (RSSI) of exchanged packets. Based on this observation, we propose the RSSR (Received Signal Strength Routing) algorithm with two variants: RSSR Election and RSSR Selection. In the RSSR Election, the next hop is dynamically elected and no packets are required for the routing task. In the RSSR Selection, neighbors exchange packets with RSSI information and the next hop of the packet is then selected from a routing table. Then, we present a novel technique for dealing with network holes even when the physical location of the nodes is unknown. This technique improves the reliability and applicability of the proposed schemes in most WSN scenarios. Our results indicate clearly that the proposed algorithms have all the benefits of a greedy forward algorithm but with better performance, better packet delivery rate and without requiring position information. We propose a new Greedy Forward algorithm for routing protocols in WSNs.It does not require localization information, but only the RSSI of the packets.It is also able to deal with nodes located near network holes.