SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
CPC-133 Telaprevir: Adverse Events in Clinical Practise: Abstract CPC-133 Table 1

Background The addition of telaprevir to peg-interferon and ribavirin represents a new treatment for hepatitis C (HCV) associated with an improvement in treatment response rates but an impairment of the safety profile. Purpose To evaluate the safety of telaprevir-based treatment in patients with HCV infection in real clinical practise in a specialty hospital. Materials and Methods Prospective and observational study of patients who started telaprevir between April and September 2012. Data were collected at each treatment visit at the hospital pharmacy through clinical interview and revision of analytical parameters. Results We enrolled 14 patients treated with telaprevir, 9 mono-infected and 5 co-infected. All patients were between 18 and 70 years old, had HCV genotype-1 infection and had at least stage 3 liver fibrosis (Metavir score).Only two patients had received no previous treatment. In the pre-treated group, 42% of the patients had a previous relapse, 33% had a partial response, and 25% had no response. 43% of patients required ribavirin dose reduction due to anaemia (haemoglobin 23% of patients needed erythropoietin-stimulating agents due to anaemia (haemoglobin 8% of patients required a blood transfusion Telaprevir was stopped in one patient because of rash. No patients discontinued treatment because of anaemia. Conclusions The safety profile of telaprevir was consistent with the findings in clinical trials. However, most of the adverse events were reported more frequently in patients in real clinical practise compared with previous results in clinical trials. These serious and frequent adverse events may be an opportunity for pharmacists to get involved to improve the safety of this treatment. No conflict of interest.
INTEREST RATE AND PRIVATE INVESTMENT IN A DEVELOPING ECONOMY: THE CASE OF CAMEROON

ABSTRACT
This research work seeks to find out the role of real interest rate on private sector investment in a developing country like Cameroon. This work provides a statistical, economical as well as an econometrical analysis of interest rate, indirect taxes, per capita income and political stability on private investment in Cameroon. This was done by collecting data on the above mentioned variables for a period of 26years; that is from 1980-2005. The ordinary least squares (OLS) technique was employed and the results were used to verify or test the various hypotheses of this study. Based on the results obtained, we observed that while interest rate, per capita income and political stability to an extent have significant effects on the level of private investment in Cameroon, indirect taxes have no significant effect on the level of private investment in Cameroon. It was also realised that other determinants such as the volume of transaction, the volume of loanable funds available, capital flight etc have a significant role in determining the level of real private investment in Cameroon. Form this study it was concluded that for any policy recommendation to be valid interest rate, real per capita income and political stability must be taken into consideration while indirect taxes must not be taken into consideration in an attempt to boost the level of private investment in a developing country like Cameroon.
Optimal sic substr ates for integrated microwave and power circuits

OSIRIS project, a Research and Innovation Action (RIA), aims at improving substantially the cost effectiveness and performance of gallium nitride (GaN) based millimetre wave components. The project proposes to elaborate innovative SiC material using isotopic sources. This material will offer thermal conductivity improvement of 30% which is important for devices dissipating a lot of power, in particular in SiC power electronics and in microwave device using GaN high electron mobility transistors (HEMT) grown on SiC semi-insulating substrates. OSIRIS project will allow reinforcing GaN technology penetration into the market by cost effectiveness of the SiC substrates and circuit performances improvement thanks to better heat spreading close to the dissipative area.
For microwave GaN/SiC HEMT this isotopic approach could create a complete shift in the currently used substrate / GaN epi-wafer technology; it intends to grow high thermal conductivity (+30%) semi-insulating SiC on top of low cost semiconducting SiC substrates (widely used by the power electronics and LED industries). Reduced layer thickness is necessary as only the top 50 to 100µm SiC wafer is really useful as the substrate itself is currently thinned to realise microstrip waveguided microwave circuits. 
For power electronics, this isotopic innovation will be essentially focused on thermal improvement, i.e. better electron mobility at a given power dissipation as mobility and drift mobility decrease with temperature and also better carrier transport thanks to lower scattering rates. Schottky and p-i-n diodes will be tested using this material, which however will have to be doped while microwave devices need semi-insulating materials.
The improved thermal SiC properties will be obtained by using single isotopic atoms for silicon and carbon, namely 28Si and 12C. The SiC wafer size will be targeted to 100mm (4-inches) which is today widely used on industry.
Synthesis of a Molecular Charm Bracelet via Click Cyclization and Olefin Metathesis Clipping

We describe the synthesis of a polycatenated cyclic polymer, a structure that resembles a molecular charm bracelet. Ruthenium-catalyzed ring-opening metathesis polymerization of an amino-containing cyclic olefin monomer in the presence of a chain transfer agent generated an alpha,omega-diazide functionalized polyamine. Cyclization of the resulting linear polyamine using pseudo-high-dilution copper-catalyzed click cyclization produced a cyclic polymer in 19% yield. The click reaction was then further employed to remove linear contaminants from the cyclic polymer using azide- and alkyne-functionalized scavenging resins, and the purified cyclic polymer product was characterized by gel permeation chromatography, (1)H NMR spectroscopy, and IR spectroscopy. Polymer hydrogenation and conversion to the corresponding polyammonium species enabled coordination and interlocking of diolefin polyether fragments around the cyclic polymer backbone using ruthenium-catalyzed ring-closing olefin metathesis to afford a molecular charm bracelet structure. This charm bracelet complex was characterized by (1)H NMR spectroscopy, and the catenated nature of the small rings was confirmed using two-dimensional diffusion-ordered NMR spectroscopy.
PRINTING MACHINE HAVING A DEVICE FOR TRIPPING THE CYLINDERS

1329777 Rotary printing presses ADAMOVSKE STROJIRNY NARODNI PODNIK 1 Nov 1971 [9 Dec 1970] 50646/71 Heading B6C According to the invention there is provided an offset printing machine of the kind wherein paper sheets are printed by means of an impression cylinder, a forme cylinder and an offset cylinder which is brought into and out of printing contact with the other cylinders by rotation of an eccentric shaft on which the offset cylinder is mounted. The machine incorporates a tripping device operable automatically to bring the offset cylinder into and out of engagement with the other cylinders as paper sheets are fed through the machine, which tripping device comprises a cam 1 fixed to the shaft 2 of the impression cylinder 3, a lifting arm 9 having at one end a follower 4 which bears on the cam and at the other end a pin 10, a first link 12 rotatably mounted on the eccentric shaft 15 and having a tooth 11 engageable with the pin 10, a stop element 16 rigidly attached to the eccentric shaft 15, a pin 18 and slot 19 engagement between the first link 12 and a first arm of the stop element 16, a second arm of the stop element being engageable with a sheet thickness adjuster 20 mounted in a bus 9 on a side wall 8 of the machine and adjustable to control the amount of rotation of the eccentric shaft it accommodates paper of different thicknesses.
Pyrotinib plus capecitabine for patients with human epidermal growth factor receptor 2-positive breast cancer and brain metastases (PERMEATE): a multicentre, single-arm, two-cohort, phase 2 trial

Patients with HER2-positive metastatic breast cancer have a high risk of developing brain metastases. Efficacious treatment options are scarce. We investigated the activity and safety of pyrotinib plus capecitabine in patients with HER2-positive metastatic breast cancer and brain metastases.We did a multicentre, single-arm, two-cohort, phase 2 trial in eight tertiary hospitals in China. Patients aged 18 years or older who had radiotherapy-naive HER2-positive brain metastases (cohort A) or progressive disease after radiotherapy (cohort B), with an Eastern Cooperative Oncology Group performance status of 0-2, received pyrotinib 400 mg orally once daily, and capecitabine 1000 mg/m2 orally twice daily for 14 days, followed by 7 days off every 3 weeks until disease progression or unacceptable toxicity. The primary endpoint was confirmed intracranial objective response rate by investigator assessment according to the Response Evaluation Criteria In Solid Tumours (version 1.1). Activity and safety were analysed in patients with at least one dose of study drug. The study is ongoing, but recruitment is complete. The study is registered with ClinicalTrials.gov, NCT03691051.Between Jan 29, 2019, and July 10, 2020, we enrolled 78 women: 51 (86%) of 59 patients in cohort A and 18 (95%) of 19 patients in cohort B had previous exposure to trastuzumab. Median follow-up duration was 15·7 months (IQR 9·7-19·0). The intracranial objective response rate was 74·6% (95% CI 61·6-85·0; 44 of 59 patients) in cohort A and 42·1% (20·3-66·5; eight of 19 patients) in cohort B. The most common grade 3 or worse treatment-emergent adverse event was diarrhoea (14 [24%] in cohort A and four [21%] in cohort B). Two (3%) patients in cohort A and three (16%) in cohort B had treatment-related serious adverse events. No treatment-related deaths occurred.To our knowledge, this is the first prospective study showing the activity and safety of pyrotinib plus capecitabine in patients with HER2-positive breast cancer and brain metastases, especially in radiotherapy-naive population. This combination deserves further validation in a randomised, controlled trial.National Cancer Centre Climbing Foundation Key Project of China, Jiangsu Hengrui Pharmaceuticals.For the Chinese translation of the abstract see Supplementary Materials section.
Investor Behavioural Pattern: An Empirical Study of the Ghana Stock Market

Behavioral finance has diffused steadily into academia and practice throughout the globe mainly as a result of works of scholars. It seeks to identify psychological factors that influence investor decision making, refuting the assumption of investor rationality and market efficiency championed by classical finance scolars. With the use of questionnaires; data was collected from investors who have invested in stocks listed on the Ghana Stock Exchange. The study found the existence of biases of representativeness, availability, risk aversion, mental accounting, anchoring and overconfidence in the Ghanaian Stock Market. Apart from the irrationality of the investor, market inefficiency was also identified.
AUGMENTED ROUTING OF DATA

Disclosed herein are systems and methods for creating an ultra-lightweight multi-tenant network virtualization model by augmenting an OSI layer 4 tuple (protocol, source IP address, destination IP address, source port, destination port) with additional private gateway-specific source and destination augmented addresses. A unique OpenVPN Augmented Address (OAA) may be created and assigned to each device on a network such as a mesh-linked system. This OAA may form part of a packet shim created with routing path information for both the source and the destination resources. Once created, the shim may be inserted into a packet header for transmission. Once the initial packet is transmitted, each hop creates its own resources for managing transmission of subsequent packets in this session. The packet shim operates to establish a communications session on layer 4 (Transport) between the requestor and the target resource which is intermediate-device agnostic.
Discrepancy between likely and actual occupancies of urban outdoor places

Abstract This paper addresses urban parks and squares and their use(r)s, focusing on the subject from two different angles: What do users do in urban outdoor spaces? What do designers think they do? It focuses particularly on the comparatively level. Firstly, the paper discusses the actual uses mapped in places, using repeated observation on different days, times and weather conditions as applied to parks and squares in two European cities. Secondly, it addresses designers’ views about usage of urban parks and squares, resulted from workshops with urban landscape designers. It shows that designers’ beliefs and awareness about uses in places, in some aspects, differ from actual use and demonstrates the value of the methodology of behaviour mapping in revealing relationships between design and use that are based on empirical evidence. The value of the paper is in concretizing the gaps between use and design of urban landscapes, and particularly in suggesting an additional way in which urban landscape designers and decision-makers may be informed or trained to gain perception about the functional relationships between people and (designed) places to effectively address design, evaluation or re-design of places.
Climbing vertical terrains with a self-contained robot

Vertical climbing on a variety of flat surfaces with a single robot has been previously demonstrated using vacuum suction, electrostatic adhesion, and biologically inspired approaches, etc. These methods generally have a low attachment strength, and it is not clear whether they can provide satisfactory attachment on vertical terrains with richer 3D features. Recent development of a climbing technology based on hot melt adhesives (HMAs) has shown its advantage with a high attachment strength through thermal bonding and viability to any solid surfaces. However, its feasibility for vertical climbing has only been proven on flat surfaces and with external energy supplies. This paper provides quantitative measurements for vertical climbing performance on five types of surfaces and terrains with a self-contained robot exploiting HMAs. We show that robust vertical climbing on multiple terrains can be achieved with reliable high-strength attachment.
Prozero - carbon based fast boats for professional use

Tuco Yacht Værft ApS (TUCO) aims to pursue a major market opportunity by developing and commercializing carbon fibre
fast boats for professional use based on a flexible and simple production platform.
Carbon excels from the other materials, especially due to the highest strength/weight relationship, which among others,
results in: savings on fuel, significant reduction of greenhouse gas emissions, larger operational range or faster boats.
Although carbon has been successfully deployed in other vessel types, such as fast ferries, recreation and high-end racing
yachts, the usage of carbon remains unproved in the market of fast boats for professional use. The commercial shipping
industry is very conservative and it is thus necessary to demonstrate the benefits of carbon fibre in the targeted market
before large-scale commercialization.
With ProZero project, TUCO will overcome prevailing market and entry barriers by partnering with key stakeholders and
building solid reference cases. In addition, we will offer a full product range – the ProZero boat series - that can be built to
order on a simple platform (using same tools) reducing the required initial investments of the whole series. The
accomplishment of the project objectives will represent a significant business opportunity for TUCO, with an expected
turnover of 23 Mio EUR, 5 years after commercialization.
The SME instrument funding plays an important strategic role in the future business development of TUCO. After assessing
the feasibility of ProZero in the SME phase 1 project, we intend to pursue our strategic vision of introducing a new line of fast
boats for professional use to the market.
ARQUITETURA E ORNAMENTO NAS FESTAS DA CANONIZAÇÃO DOS JESUÍTAS ESTANISLAU KOSTKA E LUÍS GONZAGA EM PORTUGAL (1727)

O presente texto resulta da análise dos vários relatos referentes à dupla canonização de Luís Gonzaga (1568-1591) e Estanislau Kostka (1550-1568), em 1726, que teve particular eco no contexto nas celebrações da Companhia de Jesus em Portugal. As vertentes dos programas, da arquitetura e da cenografia contribuíram para a metamorfose dos espaços e, uma vez mais, para se afirmar a capacidade que esse instituto religioso teve para organizar celebrações e outros atos performativos, que envolveram a corte e vários segmentos sociais. Considerando os diversos testemunhos que narram estes acontecimentos, procurou-se colocar em diálogo as festas de Braga, Santarém, Lisboa e Évora, interrogando a obra e compreendendo as linhas comuns a todos estes jubileus.
Smart wavy patterned implants with instructive properties for tissue regeneration by controlling the degree of fibers buckling.

In the pursuit for engineering CELL HYBRIDGE regenerative medicine implants able to regenerate skeletal tissues by controlling adult stem cell activity, we have developed an innovative method to successfully improve cell migration into electrospun scaffolds. Whereas this has a direct impact in CELL HYBRIDGE as part of the planned activities, we unexpectedly discovered that the same scaffolds display wavy patterns that have a direct influence on cell differentiation by enhancing their intrinsic capacity to produce growth factors. 
Driven by these observations, we have optimized the methodology and are able today to control the formation of such wavy patterns at a single fiber as well as multiple fiber scales by controlling the degree of buckling that the fibers are exposed to during processing. In doing so, we can reproduce the same waviness that is observed in several native tissues, among which tendons and ligaments. 
The aim of BUCKLING BRIDGES is to further investigate these instructive scaffolds as potentially smart implants for the regeneration of anterior cruciate ligaments. This will be done by further confirming our in vitro data and proof our concept by showing successful ligament regeneration in a preclinical animal model. While doing so, we will also explore the market potential of such products and develop a business plan for the creation of a spin-off company: TISSUE BRICKS.
Readout of dna methylation

DNA and chromatin modifications are essential for proper control of gene expression during development. How these marks alter transcriptional programs and modulate binding patterns of sequence specific transcription factors (TF) remains poorly understood. This currently limits our interpretation of epigenomic maps towards their incorporation into predictive models of gene regulation.
ReaDMe has the ambitious goal to systematically define the sensitivity of TFs to local levels of DNA methylation in vivo. We will use a combination of genomics, genome editing and proteomics tools to comprehensively identify transcriptional regulators that respond to DNA methylation. As a first approach, we will interrogate changes in the global TF binding landscape when DNA methylation is ablated from the genome. Using both embryonic stem cells and somatic cells, these experiments are aimed at identifying sites that are occupied by TFs in a DNA methylation dependent manner within different cellular context. Secondly, we will combine parallelized chromosomal insertions with targeted footprinting to determine the link between DNA sequence context, methylation density and TF binding. In a third approach we will define the global chromatin proteome as a function of DNA methylation.  Through the use of a novel and orthogonal proteomics assay, we will characterize DNA methylation sensitive changes in the chromatin-bound proteome. Candidate factors predicted from all approaches will be validated and functionally characterized through direct genome-wide mapping as well as loss of function analysis.  
ERC funding would enable ReaDMe to develop an integrated setup to in vivo identify and characterize where DNA methylation influences the cis-regulatory landscape by modulating binding profiles of trans-acting factors. This goal represents a crucial step towards comprehensive understanding of the genomic readout of DNA methylation and its impact on gene regulation.
The DNA-Binding Protein HU has a Regulatory Role in the Acid Stress Response Mechanism inHelicobacter pylori

Bacterial genomes are compacted by association with histone-like proteins to form a complex known as bacterial chromatin. The histone-like protein HU is capable of binding and bending the DNA molecule, a function related to compaction, protection, and regulation of gene expression. In Helicobacter pylori, HU is the only histone-like protein described so far. Proteomic analysis from our laboratory showed that this protein is overexpressed under acidic stress.We used a purified recombinant wild-type protein and two mutant proteins with the amino acid substitutions K3A/S27D and K62R/V63N/P64A to characterize the function of the N-terminal domain and the flexible arm of HU.In vitro assays for DNA protection, bending, and compaction were performed. We also designed a H. pylori hup::cat mutant strain to study the role of HU in the acid stress response. HUwt protein binds DNA and promotes its bending and compaction. Compared with the wild-type protein, both mutant proteins have less affinity for DNA and an impaired bending and compaction ability. By using qRT-PCR, we confirmed overexpression of two genes related to acid stress response (ureA and speA). Such overexpression was abolished in the hup::cat strain, which shows an acid-sensitive phenotype.Altogether, we have shown that HUwt -DNA complex formation is favored under acidic pH and that the complex protects DNA from endonucleolytic cleavage and oxidative stress damage. We also showed that the amino-terminal domain of HU is relevant to DNA-protein complex formation and that the flexible arm of HU is involved in the bending and compaction activities of HU.
Nuclear Translocation of β-catenin is Essential for Glioma Cell Survival

Identification of molecular pathways that are essential for cancer cell survival is vital for understanding the underlying biology, as well as to design effective cancer therapeutics. β-catenin, a multifunctional oncogenic protein, participates in cell development. Its multifaceted functions primarily lie to the subcellular distribution. The present study demonstrated that β-catenin accumulated in the nucleus to a greater extent in high-grade gliomas compared with low-grade gliomas. In addition, nuclear localization correlated with a worse prognosis for patients, as determined by immunohistochemical analysis of 74 glioma samples. Nuclear expression of β-catenin was down-regulated in LN229 and U87 glioma cells by a small molecule inhibitor of β-catenin/TCF4 signaling, demonstrating strongly inhibited β-catenin/TCF4 transcriptional activity and STAT3 luciferase activity, as well as decreased mRNA and protein levels of nuclear β-catenin, TCF4, EGFR, AKT1, AKT2 and STAT3. Furthermore, repressed nuclear translocation of β-catenin resulted in inhibition of proliferation and invasiveness, and also induced apoptosis of glioma cells. Similar results were also observed in vivo; intratumoral injection of such small molecule inhibitor downregulated expression of nuclear β-catenin, TCF4, and components of the EGFR pathway, and also delayed tumor growth in nude mice harboring subcutaneous U87 xenografts. Results from the present study provided evidence that nuclear accumulation of β-catenin participated in malignant progression of gliomas and implicated poor prognosis, highlighting it as a potential therapeutic target for gliomas.