SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Could molecular effects of Caulerpa racemosa metabolites modulate the impact on fish populations of Diplodus sargus?

The green alga Caulerpa racemosa is a non-native, invasive species in the Mediterranean, and an important stressor for several native organisms. The algal capacity to produce secondary metabolites has been suggested to modulate success of the C. racemosa invasion, although many of potentially involved biological pathways still remain unexplored. In this respect, the aim of the present study was to investigate some molecular and cellular effects in the white seabream Diplodus sargus, an ecologically key species, which included the alien C. racemosa in its diet. Organisms were sampled in 2 seasonal periods from 3 locations of Southern Italy, each characterized by different levels of algal abundance. The level of caulerpin, one of the main secondary algal metabolites, in fish tissues has been used as an indicator of the trophic exposure to the seaweed and related with molecular and cellular responses. Chemical analyses indicated that fish from invaded sites can accumulate caulerpin, with liver concentrations ranging from a few up to hundreds of μg/g. Biomarkers analyses revealed only limited alterations of the main antioxidant defences, such as glutathione reductase and levels of glutathione; on the other hand, increased enzymatic activities of cytochrome P450, glutathione S-transferases and acyl CoA oxidase, as well as enhanced gene transcription for peroxisome proliferator-activated receptor alpha, cytochrome P4501A and vitellogenin 1 were observed in fish more exposed to C. racemosa as indicated by liver concentrations of caulerpin higher than 50 μg/g. Despite a direct molecular relationship with this algal metabolite could not be established, our results suggest that a C. racemosa enriched diet can modulate biotransformation and fatty acids metabolism of D. sargus. Assessing whether similar effects represent short- or long-term effects will be of crucial importance to understand consequences on the general health status and reproductive performance of exposed key fish species in the Mediterranean region.
Analysis of vegetation and land cover dynamics in north-western Morocco during the last decade using MODIS NDVI time series data

Abstract. Vegetation phenology as well as the current variability and dynamics of vegetation and land cover, including its climatic and human drivers, are examined in a region in north-western Morocco that is nearly 22 700 km2 big. A gapless time series of Normalized Differenced Vegetation Index (NDVI) composite raster data from 29 September 2000 to 29 September 2009 is utilised. The data have a spatial resolution of 250 m and were acquired by the Moderate Resolution Imaging Spectroradiometer (MODIS) sensor. The presented approach allows to compose and to analyse yearly land cover maps in a widely unknown region with scarce validated ground truth data by deriving phenological parameters. Results show that the high temporal resolution of 16 d is sufficient for (a) determining local land cover better than global land cover classifications of Plant Functional Types (PFT) and Global Land Cover 2000 (GLC2000) and (b) for drawing conclusions on vegetation dynamics and its drivers. Areas of stably classified land cover types (i.e. areas that did not change their land cover type) show climatically driven inter- and intra-annual variability with indicated influence of droughts. The presented approach to determine human-driven influence on vegetation dynamics caused by agriculture results in a more than ten times larger area compared with stably classified areas. Change detection based on yearly land cover maps shows a gain of high-productive vegetation (cropland) of about 259.3 km2. Statistically significant inter-annual trends in vegetation dynamics during the last decade could however not be discovered. A sequence of correlations was respectively carried out to extract the most important periods of rainfall responsible for the production of green biomass and for the extent of land cover types. Results show that mean daily precipitation from 1 October to 15 December has high correlation results (max. r2=0.85) on an intra-annual time scale to NDVI percentiles (50 %) of land cover types. Correlation results of mean daily precipitation from 16 September to 15 January and percentage of yearly classified area of each land cover type are medium up to high (max. r2=0.64). In all, an offset of nearly 1.5 months is detected between precipitation rates and NDVI values. High-productive vegetation (cropland) is proved to be mainly rain-fed. We conclude that identification, understanding and knowledge about vegetation phenology, and current variability of vegetation and land cover, as well as prediction methods of land cover change, can be improved using multi-year MODIS NDVI time series data. This study enhances the comprehension of current land surface dynamics and variability of vegetation and land cover in north-western Morocco. It especially offers a quick access when estimating the extent of agricultural lands.
THE EFFECT OF CEMENT MODIFICATION ON THE RHEOLOGICAL PROPERTIES OF CEMENT PASTE

Experimental tests have determined the effect of slag, opoka (silica-calcite sedimentary rock), silica fume (SiO2) suspension, dolomite dust and sodium silicate solution (NaSS) together with the polycarboxylatether based plasticizing admixture on the yield stress and viscosity of Portland cement paste the rheological properties of which have been defined applying a rotational viscometer with co-axial cylinders. The tests have revealed that slag, opoka, silica fume suspension and dolomite dust added to cement paste by replacing 10% of Portland cement (by weight) have an effect on the yield stress and viscosity of the paste subject to the form and fineness of additive particles. When 10wt% of Portland cement is replaced with slag cement, the yield stress of Portland cement paste reduces by about 25.9%, and viscosity increases by about 3.5 times compared with the yield stress and viscosity of reference cement paste. The yield stress of Portland cement paste with 0.5% NaSS admixture increases insignificantly, and viscosity grows approximately twice compared with reference cement paste. The tests have also showed that the modifying admixtures of Portland cement paste enable to control the rheological properties of cement paste.
The getreal initiative

The GetReal Initiative brings together partners from the IMI GetReal project to drive the adoption of tools, methodologies and best practices from IMI GetReal and increase the quality of real-world evidence (RWE) generation in medicines development and regulatory/HTA processes across Europe. We will establish, in Work Package (WP) 1, a Think Tank, a number of Task Forces and a RWE Research Community. The Think Tank will consist of international thought leaders and will discuss, assesses and give recommendations on the opportunities and barriers to the generation, use and acceptability of RWE. They will act as ambassadors for the use of RWE during the project and beyond, enagaging with key stakeholder groups to drive policy debate and facilitate the uptake of the outputs of IMI GetReal and the GetReal Initiative. The GetReal Taskforces will drive the focused development of tangible solutions to the key challenges identified in IMI GetReal and the Think Tank. The initial three task forces will be: (i) Pragmatic Trials (design, operational feasibility and analysis/the GetReal PragMagic tool), (ii) network meta-analysis and benefit risk assessment (incl. the GetReal ADDIS tool) and (iii) Statistical Approaches for enriching RCTs with real-world data. The GetReal Research Community will consist of researchers and organisations active in the field of RWE generation, regulators, HTAs, physicians and patients. The Community will review and comment on any GetReal Initiative guidelines, recommendations or white papers ahead of their finalisation, will have access to all the GetReal tools and outputs, receive regular newsletters and receive invitations to attend stakeholder events. The project will also invest in long term sustainability of the GetReal Initiative and the tools on a not-for-profit basis (WP2). The project is supported by professional experienced consortium management (WP3) and an ethics work package (WP4).
Application of the exact operational matrices for solving the Emden-Fowler equations, arising in Astrophysics

The objective of this paper is applying the well-known exact operational matrices (EOMs) idea for solving the Emden-Fowler equations, illustrating the superiority of EOMs over ordinary operational matrices (OOMs). Up to now, a few studies have been conducted on EOMs ; but the solved dierential equations did not have high-degree nonlinearity and the reported results could not strongly show the excellence of this new method. So, we chose Emden-Fowler type dierential equations and solved them utilizing this method. To conrm the accuracy of the new method and to show the preeminence of EOMs over OOMs, the norm 1 of the residual and error function for both methods are evaluated for multiple m values, where m is the degree of the Bernstein polynomials. We report the results by some plots to illustrate the error convergence of both methods to zero and also to show the primacy of the new method versus OOMs. The obtained results demonstrate the increased accuracy of the new method.
A Simple Method for Analyzing Actives in Random RNAi Screens: Introducing the “H Score” for Hit Nomination & Gene Prioritization

Due to the numerous challenges in hit identification from random RNAi screening, we have examined current practices with a discovery of a variety of methodologies employed and published in many reports; majority of them, unfortunately, do not address the minimum associated criteria for hit nomination, as this could potentially have been the cause or may well be the explanation as to the lack of confirmation and follow up studies, currently facing the RNAi field. Overall, we find that these criteria or parameters are not well defined, in most cases arbitrary in nature, and hence rendering it extremely difficult to judge the quality of and confidence in nominated hits across published studies. For this purpose, we have developed a simple method to score actives independent of assay readout; and provide, for the first time, a homogenous platform enabling cross-comparison of active gene lists resulting from different RNAi screening technologies. Here, we report on our recently developed method dedicated to RNAi data output analysis referred to as the BDA method applicable to both arrayed and pooled RNAi technologies; wherein the concerns pertaining to inconsistent hit nomination and off-target silencing in conjugation with minimal activity criteria to identify a high value target are addressed. In this report, a combined hit rate per gene, called "H score", is introduced and defined. The H score provides a very useful tool for stringent active gene nomination, gene list comparison across multiple studies, prioritization of hits, and evaluation of the quality of the nominated gene hits.
PAPER MACHINE FELTS

The present invention relates to a felt for use in papermaking machines showing enhanced resistance to degradation in the presence of peroxide which felt comprises a woven base and a sheet contacting layer attached thereto characterised in that at least one of said layer and said woven base comprises fibres of polyamide 12,12 formed by extrusion of a melt of polyamide 12,12 having intrinsic viscosity of not less than 0.65 dl/gram.
Creazione di reti transfrontaliere in ambito equestre

The project aims to exchange best practices and common methodologies for the creation of networks around the following themes: social integration, promoting sports tourism, regional marketing across borders, creation of innovative professionals. 
Reference areas are the Corsica and the provinces of Nuoro, Sassari and Livorno. 
Overall project objective is to promote institutional cohesion and the exchange of good practices through networking between facilities, services and initiatives to enhance, through the sharing of methodologies, the practice of equestrian activities across borders, with the involvement of local and local associations. 
The project consists of the target institutions, local authorities, associations that will be involved in the creation of networks. With reference to individual actions, then this is the target users of the service offered by the various networks, issues related to the horse, and between these children and people with psycho-motor, which will be special activities for sports and horse therapy. 
The project activities are as follows: 
Realization of "Pony Camp" / Workshop Ethology / Training of trainers within the hippotherapy / "Paralympics" / seminars on topics horse Racing / Endurance Racing / jumping / "Trekking theater" / Days event in the equestrian field / Enhancement of Sardinian horse / Creation of "equestrian Brigades" / Participation in fairs / promotion inside and outside
DRYER FELT RUN

A paper web dryer section (5) has horizontal upper and lower tiers of dryers (7, 8) defining generally triangular pockets (9). An endless dryer felt (10) is trained to run a paper web (W) sinuously successively and in direct contact on the upper perimeter areas of the upper (7) and lower (8) tier dryers. Broke is ejected downwardly from the pocket (9). To facilitate such broke ejection, dryer felt roll wrap enhancing felt rolls (19, 20) in the pockets are especially oriented for this purpose and define a respective broke-receiving and ejecting subpocket (21) under the upper tier dryers (7) at each pocket (9).
Unravelling cluster root development in white lupin

Plant development is continuous throughout their lifetime and reflects their ability to adapt to their environment. This developmental plasticity is very obvious in the development of the root system. Surprisingly, the fundamental mechanisms of root development have been studied into great detail but the effect of the environment on its plasticity is still largely unknown. I will use phosphate, since this nutrient has a very low mobility in soil, as a mean to study plant developmental adaptation in white lupin.
This species has developed extreme adaptive mechanism to improve phosphate uptake by producing structures called “cluster roots”. They are dense clusters of lateral roots with determinate development and highly specific physiology. I will develop new tools to identify cluster root mutants in white lupin, sequence white lupin genome, perform tissues specific transcriptomics and perform full molecular characterization of selected genes. This project will also lead me to compare adaptive mechanisms between white lupin and narrow-leafed lupin, a closely related species that does not produce cluster roots. We will also test whether it is possible to transfer the ability to form cluster roots in this species. Altogether, this project will lead to a major advance in our capacity to understand how plants are able to sense and respond to their environment and how evolution has selected adaptive developmental mechanisms to improve their capacity to use limited resources.
This project focuses on the most extreme developmental adaptation produced in response to phosphate starvation. It is ambitious, as it will necessitate the development of several tools. However, it is highly feasible since it builds on my previous experience and important outcome can be expected in term of crop improvement and means to reduce the use of phosphate fertilizers.
METHOD FOR OPERATING A WATER-CARRYING HOUSEHOLD APPLIANCE

The invention relates to a method for operating a water-carrying household appliance, especially a dishwasher or a tumble dryer, comprising a plurality of successive partial program steps, a first medium being heated at least temporarily by a first heating element (24) in at least one partial program step, and the product to be treated then being heated by being subjected to the heated first medium. According to the invention, when the first heating element (24) is inactive, a second medium is at least temporarily heated by a second heating element (23) and the product to be treated is heated by the heated second medium.
Prokka: rapid prokaryotic genome annotation

The multiplex capability and high yield of current day DNA-sequencing instruments has made bacterial whole genome sequencing a routine affair. The subsequent de novo assembly of reads into contigs has been well addressed. The final step of annotating all relevant genomic features on those contigs can be achieved slowly using existing web- and email-based systems, but these are not applicable for sensitive data or integrating into computational pipelines. Here we introduce Prokka, a command line software tool to fully annotate a draft bacterial genome in about 10 min on a typical desktop computer. It produces standards-compliant output files for further analysis or viewing in genome browsers.Prokka is implemented in Perl and is freely available under an open source GPLv2 license from http://vicbioinformatics.com/.
Estructura urbana y condiciones de movilidad en las periferias populares de Lima y Bogotá: desafíos y método de análisis

Este artículo presenta parte del trabajo realizado en el marco del programa Modural “Las prácticas de movilidad sostenible en las metrópolis de América Latina: estudio comparativo de Bogotá y Lima”, iniciado en enero de 2020. Modural es un programa internacional y plu­ridisciplinario financiado por la anr(Agencia Nacional de la Investigación de Francia). Está enfocado en estudiar las prácticas de movilidad sostenible en la situación específica de las periferias populares. El artículo tiene dos objetivos. Primero, evidenciar los patrones socio-espaciales de desigualdad de movilidad y las dificultades en las periferias en Lima y Bogotá. Segundo, presentar la metodología de selección de las zonas con mayor desventaja social y mayores dificultades de movilidad cotidiana.
R-tools

Wikisystems are proven to be good for producing text and knowledge in collaborative manner but they are not designed to handle large amounts of numerical data. We needed a system that is capable for producing text and run calculations from datasets. For this purpose we created Opasnet which is a Mediawiki with integrated statistical computing extension and an external database for data. In our demonstration we will show how R (statistical software) can be integrated into Mediawiki as an extension (R-Tools) and how it can be used directly from wiki pages. This extension enables users to write R-code, run it and see the results of the calculation on the wiki page. R-tools can use data from external databases and this functionality is also demonstrated. First R-Tools demonstration was held at Wikisym 2012 in Linz. Now we will focus on its new features developed within this year.
Preferential Glutathione Conjugation of a Reverse Diol Epoxide Compared with a Bay Region Diol Epoxide of Benzo[a]pyrene in Human Hepatocytes

Many studies have examined the relationship between polymorphisms in glutathione S-transferase genes and cancer in people exposed to polycyclic aromatic hydrocarbons (PAH) such as benzo[a]pyrene (BaP), but the results to date have been modest. Missing from these studies has been an exploration of the formation of the appropriate glutathione conjugates in humans. We incubated human hepatocytes from 10 donors with racemic anti-BaP-7,8-diol-9,10-epoxide (BPDE), believed to be a major ultimate carcinogen of BaP, or with the noncarcinogenic reverse diol epoxide, racemic anti-BaP-9,10-diol-7,8-epoxide (rev-BPDE). Incubations were carried out for 12 or 24 h. We used high-performance liquid chromatography-electrospray ionization-tandem mass spectrometry-selected reaction monitoring at m/z 464 --> m/z 317 to analyze the incubation mixtures for the mercapturic acid products that would result from glutathione conjugation. The standard mercapturic acids were synthesized by reaction of BPDE or rev-BPDE with N-acetylcysteine. We obtained convincing evidence in human hepatocytes for mercapturic acid formation from rev-BPDE in all 10 samples, in amounts up to 17 pmol/ml. However, we could detect mercapturic acids from BPDE in only 1 of 10 samples (0.05 pmol/ml). Taken together with our similar previous results of analyses of phenanthrene metabolites in human hepatocytes and human urine, the results of this study indicate that conjugation of BPDE with glutathione is a minor pathway in humans, indicating that glutathione S-transferase genotyping is not an effective method for assessing risk of PAH-induced cancer in humans, at least with respect to the diol epoxide pathway of PAH carcinogenesis.
Territorial Impact Package for Transport and Agricultural Policies

The Territorial Agenda of the EU highlights the increasing territorial influence of Community policies and states that this should be taken into consideration by policy makers. The Green Paper on Territorial Cohesion states that coordination between sectoral and territorial policies is important to maximise synergies and to avoid possible conflicts. This project builds on the earlier achievements of the ESPON 2006 Programme. The methodology, indicators and the prototype “TEQUILA” model will be further developed and made operational to receive a tool for the ex-ante assessment of territorial impacts of policies. The tool will be tested on transport and agricultural policy and deliver evidence on the territorial impact of these policies. The results are of direct use for creating better policy coordination.
The Neuropsychology of High-level Vision

This book provides a state-of-the-art review of high-level vision and the brain. Topics covered include object representation and recognition, category-specific visual knowledge, perceptual processes in reading, top-down processes in vision -- including attention and mental imagery -- and the relations between vision and conscious awareness. Each chapter includes a tutorial overview emphasizing the current state of knowledge and outstanding theoretical issues in the authors' area of research, along with a more in-depth report of an illustrative research project in the same area. The editors and contributors to this volume are among the most respected figures in the field of neuropsychology and perception, making the work presented here a standard-setting text and reference in that area.