SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Competition for space in development and diseases

Developing tissues have a remarkable plasticity illustrated by their capacity to regenerate and form normal organs despite strong perturbations. This requires the adjustment of single cell behaviour to their neighbours and to tissue scale parameters. The modulation of cell growth and proliferation was suggested to be driven by mechanical inputs, however the mechanisms adjusting cell death are not well known. Recently it was shown that epithelial cells could be eliminated by spontaneous live-cell delamination following an increase of cell density. Studying cell delamination in the midline region of the Drosophila pupal notum, we confirmed that local tissue crowding is necessary and sufficient to drive cell elimination and found that Caspase 3 activation precedes and is required for cell delamination. This suggested that a yet unknown pathway is responsible for crowding sensing and activation of caspase, which does not involve already known mechanical sensing pathways. Moreover, we showed that fast growing clones in the notum could induce neighbouring cell elimination through crowding-induced death. This suggested that crowding-induced death could promote tissue invasion by pretumoural cells.
Here we will combine genetics, quantitative live imaging, statistics, laser perturbations and modelling to study crowding-induced death in Drosophila in order to: 1) find single cell deformations responsible for caspase activation; 2) find new pathways responsible for density sensing and apoptosis induction; 3) test their contribution to adult tissue homeostasis, morphogenesis and cell elimination coordination; 4) study the role of crowding induced death during competition between different cell types and tissue invasion 5) Explore theoretically the conditions required for efficient space competition between two cell populations.
This project will provide essential information for the understanding of epithelial homeostasis, mechanotransduction and tissue invasion by tumoural cells
Urea-Assisted Room Temperature Stabilized Metastable β-NiMoO<sub>4</sub>: Experimental and Theoretical Insights into its Unique Bifunctional Activity toward Oxygen Evolution and Supercapacitor

Room-temperature stabilization of metastable β-NiMoO4 is achieved through urea-assisted hydrothermal synthesis technique. Structural and morphological studies provided significant insights for the metastable phase. Furthermore, detailed electrochemical investigations showcased its activity toward energy storage and conversion, yielding intriguing results. Comparison with the stable polymorph, α-NiMoO4, has also been borne out to support the enhanced electrochemical activities of the as-obtained β-NiMoO4. A specific capacitance of ∼4188 F g-1 (at a current density of 5 A g-1) has been observed showing its exceptional faradic capacitance. We qualitatively and extensively demonstrate through the analysis of density of states (DOS) obtained from first-principles calculations that, enhanced DOS near top of the valence band and empty 4d orbital of Mo near Fermi level make β-NiMoO4 better energy storage and conversion material compared to α-NiMoO4. Likewise, from the oxygen evolution reaction experiment, it is found that the state of art current density of 10 mA cm-2 is achieved at overpotential of 300 mV, which is much lower than that of IrO2/C. First-principles calculations also confirm a lower overpotential of 350 mV for β-NiMoO4.
Fishing TOURIsm for a Sustainable tourism development in the MEDiterranean area

TOURISMED is a project aimed at testing and transferring a fishing tourism business model in the coastal territories of Italy, Cyprus, Greece,Albania,France and Spain as a way to promote a sustainable approach to tourism,while fostering the preservation of the marine ecosystem and traditional fishing culture of the MED region._x000D_
These areas face the common challenge of finding new solutions for the worrying depletion of marine resources, the decline of the artisanal fishing sector and the negative impacts of tourism such as social dislocation,loss of cultural heritage and ecological degradation.As a response,the project objective is to promote fishing tourism as a sustainable coastal and maritime tourism practice in the MED area._x000D_
Expected changes concern an improved use of resources by artisanal fishers,a diversification of income in the sector and a better valorization of coastal traditional heritage and local seafood._x000D_
The project will produce a pilot test of the model and an evaluation tool to assess its replication in the concerned area. A training course will involve fishermen to implement the touristic itineraries in synergy with local tourism operators.The final model will be promoted by a web tool to clients willing to set up a fishing tourism business, while an interactive map of itineraries will be used to reach tourists.Protocols with public bodies and fishing associations (MoU) will be followed by policy recommendations to ensure sustainability of project’s impacts.
Put Yourself in My Shoes: Perspectives of Adolescents about What Makes an Obesity Intervention Effective

Purpose: This study aims to investigate the adolescents’ perspectives about 1) the changing process promoted by a weight management program; 2) the factors which may act as facilitators and barriers to obesity management; 3) the strategies that should be included in order to design a successful weight management program. Methods: Data were collected by in-depth interviews and focus group discussions with 16 overweight adolescents, aged 12 - 18 years. Thematic analysis was used for analysing the data. Results: Findings suggest that attributions (internal and external), functions (barriers and facilitators) and perceptual changes (lifestyle and body and mind changes) play distinct roles in the changing process. Interactions recognized as high quality ones, acquisition of new knowledge and competencies and encouragement throughout the process, were identified as facilitators. Negative patterns of interaction, collection of anthropometric data and internal resistances, were identified as barriers. The relevance of developing systemic interventions including family and peers, and the use of Information and Communication Technologies were highlighted. Conclusion: This study aims to contribute for a deeper understanding of the factors and processes behind adherence to weight management. Implications for the design of future more effective strategies and implementation of appropriate interventions are discussed.
Topographic radiation modeling and spatial scaling of clear-sky land surface longwave radiation over rugged terrain

Abstract Longwave radiation (5–100 μm) is a critical component of the Earth's radiation budget. Most of the existing satellite-based retrieval algorithms are valid only for flat surfaces without accounting for topographic effects. This causes significant errors. Meanwhile, the fixed spatial resolution of remote sensing data makes it difficult to link the satellite-derived longwave radiation to different land models running on various scales. These deficiencies result in an urgent need for topographic modeling and spatial scaling studies of longwave radiation. In this paper, a longwave topographic radiation model (LWTRM) is proposed that quantifies all possible radiation-affecting factors over rugged terrain. For driving the LWTRM, a hybrid method for simultaneously deriving multiple components of longwave radiation from MODIS data is suggested based on artificial neuron networks (ANN) and the radiative transfer simulation. Topographically corrected longwave radiation is then derived by coupling the ANN outputs and LWTRM. Based on this, a general upscaling strategy for longwave radiation is presented. The results demonstrate that: (1) both the proposed LWTRM and the upscaling strategy are rather effective and work well over rugged areas; (2) the ANN-based retrieval method can produce longwave radiation with better accuracy(RMSE
Road marker base with improved adherence and light transmission

A method of forming a road marker and the resulting road marker including a metallic base and a light transmitter, includes coating the metallic base with an oxidation inhibiting layer; and mounting the light transmitter on the base. The coating may be performed before the mounting. The coating may be a plating.
Sustainable and standalone oxyhydrogen powered heat generator box

INSEEF has worked for more than 100 clients in the farming and agriculture sector including pig, poultry and dairy farms of all sizes as well as mushroom growers among others, who have a high and uninterrupted energy need mainly for heating applications. Farms are often located in in remote rural areas, where electricity access can be difficult. Consequently, current biomass solutions that have not grid access operate with diesel generators, which can be costly to maintain (Minimum 250l/gasoil per /month plus maintenance costs, and rely on external diesel supplies that produce significant CO2 emissions (8,65 CO2/year versus 0,65 for Enerbox). As a result, a significant number of our clients have expressed interest in reliable, standalone and cost effective biomass energy generators. EU off grid rural agriculture and farms will be the primary market for Enerbox, targeting both new thermal energy installations as well as existing ones.  Enerbox  aim is to  introduce a disruptive off-grid scalable solution to EU the biomass market, providing stable access to thermal energy supply, flatten input-costs and make the most of low value feedstock. It will be a competitive solution for (mostly) off-grid applications that require a reliable and clean source of thermal energy offering a low levelized cost of thermal energy. To reach this aim, Enerbox project  integrates efficiently two complementary sources of renewable energy (PV and biomass)plus energy storage, to produce steady and reliable thermal energy, and with the inclusion of an H2 sub-system that incorporates an innovative process to enrich the thermal potential of the waste biomass energy by mixing it with auto-generated oxyhydrogen gas obtained from reverse electrolysis,  all in a modular compact transportable solution.
Interacting Living Polymers Confined between Two Surfaces

We present predictions on the equilibrium behavior of solutions of living polymers confined in a gap between surfaces, including the ensuing potential of mean force between those surfaces (the disjoining potential). We highlight the occurrence of a transition upon narrowing the gap, which arises from a cooperative simultaneous increase of the local density and degree of polymerization. At this transition, many properties of the confined solution, including the disjoining potential, change by orders of magnitude over a minute change of the surface separation. These results were obtained owing to two extensions to a previously introduced self-consistent field-propagator formalism. (i) We derive this formalism from a free-energy functional of the distribution of chain lengths and configurations. This enables evaluation of thermodynamic properties, including the disjoining potential. (ii) We solved for a system confined between two surfaces.
“What is the Spirit of this Gathering?” Indigenous Sport Policy-Makers and Self-Determination in Canada

In this article, I examine how the process of Indigenous participation in policy-making pertaining to the development of federal sport policy in Canada is connected to Indigenous forms of self-determination. By conducting semi-structured interviews with six Indigenous sport policy-makers, I investigate how their respective thoughts, experiences, and actions shape their perspective on self-determination. My analysis shows that a focus on relationships was at the center of the interviewed Indigenous sport policy-makers’ approaches to the promotion of Indigenous self-determination. Furthermore, the relational nature of Indigenous policy-makers’ identities was also central to their pursuit of self-determination. The promotion of family and community type relationships with government representatives could be used as an outcome of policy-making, in addition to traditional policy directives.
A real-world comparison of tisagenlecleucel and axicabtagene ciloleucel CAR T cells in relapsed or refractory diffuse large B cell lymphoma

Abstract Axicabtagene ciloleucel (axi-cel) and tisagenlecleucel (tisa-cel) have both demonstrated impressive clinical activity in relapsed/refractory (R/R) diffuse large B cell lymphoma (DLBCL). In this study, we analyzed the outcome of 809 patients with R/R DLBCL after two or more previous lines of treatment who had a commercial chimeric antigen receptor (CAR) T cells order for axi-cel or tisa-cel and were registered in the retrospective French DESCAR-T registry study ( NCT04328298 ). After 1:1 propensity score matching ( n = 418), the best overall response rate/complete response rate (ORR/CRR) was 80%/60% versus 66%/42% for patients treated with axi-cel compared to tisa-cel, respectively ( P &lt; 0.001 for both ORR and CRR comparisons). After a median follow-up of 11.7 months, the 1-year progression-free survival was 46.6% for axi-cel and 33.2% for tisa-cel (hazard ratio (HR) = 0.61; 95% confidence interval (CI), 0.46–0.79; P = 0.0003). Overall survival (OS) was also significantly improved after axi-cel infusion compared to after tisa-cel infusion (1-year OS 63.5% versus 48.8%; HR = 0.63; 95% CI, 0.45–0.88; P = 0.0072). Similar findings were observed using the inverse probability of treatment weighting statistical approach. Grade 1–2 cytokine release syndrome was significantly more frequent with axi-cel than with tisa-cel, but no significant difference was observed for grade ≥3. Regarding immune effector cell-associated neurotoxicity syndrome (ICANS), both grade 1–2 and grade ≥3 ICANS were significantly more frequent with axi-cel than with tisa-cel. In conclusion, our matched comparison study supports a higher efficacy and also a higher toxicity of axi-cel compared to tisa-cel in the third or more treatment line for R/R DLBCL.
A methodology for static and dynamic scheduling of automation tasks in reconfigurable production systems

The development of distributed architectures for logic control systems has a number of advantages related to the system capability of being reconfigurable and responsive toward changes of production requirements. However, the execution of various portions of the control system on multiple physical resources represents a challenge as for the control task scheduling and synchronization perspectives. The proposed work outlines a scheduling approach – named ISA (Integrated Scheduling Architecture) – supporting the dynamic execution of control tasks in distributed control systems while enriching the control nominal behavior with data gathered from the shop-floor. The benefits of the approach have been validated with reference to a flexible transportation system operating in a pilot assembly line.
Cross Marketing Strategies for Culture and Tourism for more Attractiveness and Competitiveness for Cities and Regions

Economic and social disparities, mainly peripheral patterns, emigration, missing access to foreign markets/knowledge transfer endanger the competitiveness of the regions involved in the project. It promotes regional and transnational cooperation as well as attractiveness and competitiveness of cities and regions through cultural tourism, thus minimizing effects of demographic and social change while improving the quality of life. In terms of territorial cohesion the project fights the significant outward migration from rural areas by stressing their cultural potential exploiting it for sustainable economic use and developing it as part of regional identity.
The project aims at preserving cultural sites, landscapes, resources starting from Romanesque integrating other period and cultural aspects, fostering their sustainable use. Capitalisation focuses on cultural tourism use for generating an economic base. Disadvantaged regions will be connected to cultural centres by employing ICT (audio guides system), promoting cooperation of small and medium sized enterprises, opening access to markets, searching for multi-sectoral approaches and integrated cultural economic concepts. Further 7,6 million citizens from the involved regions will benefit from the creation of strong regional/European identity based on common cultural-historical roots (cultural tourism experience, project communication, events),thus promoting valorisation of traditional activities. 
Furthermore, 11,3 million domestic and European tourists can be addressed with deepened experience of Central Europeans cultural variety as well as 1 million guests from overseas. Job opportunities for youth, student/guides/actors exchange and training, volunteering, product development targeting kids/youth also address topics related to demographic and social change.
CrossCulTour considers past efforts of Interreg IIIB-project TRANSROMANICA and adds diversity of cultural heritage (CH) potential in Central Europe, recognising that a wider approach with cross-marketing-ability permits to capitalise cultural resources for a better attractiveness of cities and regions. 
The idea is to search for synergies, use former results and develop cross-marketing approaches to address markets with competitive cultural tourism products together, thereby assisting small and medium sized enterprises in creating employment, increase regional income but also assuring sustainable knowledge transfer and exchange.
The influence of ionic liquid solvation on the chemistry of frustrated lewis pairs

Hydrogen (H2) is an important reagent for the chemical industry as well as representing a promising carbon-free fuel source when made from renewable sources. H2 needs to be activated for these applications, generally using rare, expensive and often toxic transition metal catalysts. Metal-free H2 activation has recently been demonstrated using the concept of ‘frustrated Lewis pairs’ (FLPs) based on main group elements such as phosphorous and boron rather than transition metals. FLPs are somewhat limited in scope due to the highly reactive Lewis acids (LAs) and bases (LBs) required for H2 activation which can lead to side reactions with substrates and solvents. The use of less reactive FLPs is restricted by the H2 activation step. This project addresses this problem by using the unique solvating ability of ionic liquids (ILs) to control the reactivity of FLPs for H2 activation. Many FLPs form ions when they react with H2. To promote H2 activation, it is essential that the reverse reaction (ion recombination to form H2) is prevented. The high ion dissociation power of ILs should prevent the recombination of these ions, leading to more efficient H2 activation. The impact of ILs on H2 activation by FLPs will be investigated in the context of synthesis and fuel cell applications. Successful use of ILs for this purpose would substantially increase the scope of FLP catalysts, reducing the reliance on transition metals thereby decreasing the potential cost and environmental impact of H2 activation processes. This project would represent the first study on the effect of ILs on FLP reactivity and combines the collective expertise of Prof. Welton (ILs) and Dr Ashley (FLPs) at Imperial College (IC) with the applicant’s background in ILs, kinetics and intermolecular interactions, while providing the applicant with productive collaborative partners and advanced training in catalysis, electrochemistry, IL and FLP chemistry to propel him towards an independent research career.
A Review of the European Union Countries on Cross-border Mergers and Acquisitions Market

It is a well-known fact that the main objective of every corporation is to generate profits and enhance its shareholders' wealth. Corporate growth may be achieved either internally (through organic growth) or externally (through mergers and acquisitions). In parallel with global trends, corporate growth is achieved by cross-border mergers and acquisitions (M&amp;As) that have increased dramatically in economies especially over the last few decades. It is also established that mergers and acquisitions come in waves - so far, six waves have been researched. The main aim of the presented paper is to analyse the activity of the European Union countries on the M&amp;As market and to describe the main motives for cross-border M&amp;As and how the performance of cross-merger M&amp;As is measured.
AUTOMATIC BALANCING SYSTEM FOR ROTATING SYSTEMS

The invention relates to a device (10) for balancing a system (12) that rotates about a rotation axis (18), comprising a plurality of raceways (36) disposed about the rotation axis of the system (12) for a plurality of mobile balancing bodies (22). The system is further characterized in that at least one of the balancing bodies (22) consists of at least two materials having different densities (40, 41, 42, 44, 48). The materials of the balancing bodies are disposed in such a manner that the balancing body is elastically deformable in the area of possible contact with other balancing bodies (22) and/or the raceway (36).
Alpine windharvest. Development of information base regarding potentials and the necessary technical, legal and socio-economic conditons for expanding wind energy in the Alpine space

Chief objective is to develop and pull together knowledge and experience essential for developing, regulating and implementing wind power. This requires many scientific disciplines and affects all levels of government (spatial planning, nature protection, environmental impact, road and grid infrastructure, and appropriate tariff regulation), entrepreneurs, potential investors, nature protection organisations and local residents. The options of wind energy in the Alps are transnational in character. Transnational co-operation between scientists and practitioners will produce synergy effects and cross-fertilisation with regard to problem awareness, data sets, new approaches and solutions for government and private actors. A common approach by states and regions concerned will encourage a harmonised European approach and a common interregional strategy to implement windpower in the Alpine Space. The project supports specific site developments by providing additional regional overviews about suitable sites.