SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Genie:  geoengineering and negative emissions pathways in europe

Geoengineering technologies, such as solar radiation management (SRM), and negative emissions technologies, such as greenhouse gas removal (GGR), are emerging options to address climate change. This project will investigate the environmental, technical, social, legal, and policy dimensions of GGR and SRM. We provide an urgently needed interdisciplinary and holistic perspective of these technologies in order to understand conditions under which they might be deployed at scale. Our meta-analytical framework integrates insights from social science, engineering and physical science disciplines to provide a comprehensive view of GGR and SRM in the transition to climate neutrality in Europe and the world. The project will conduct excellent research and generate a robust, scientific assessment for evidence-based policymaking. Our research framework consists of three pillars—techno-economic systems, socio-technical systems, and systems of political action—within which we place six work packages (WPs). These are: (1) Understanding the current state and future potential of GGR and SRM technologies in terms of their technical and economic features; (2) Analysing bottlenecks in transitions to climate neutrality and their implications for deployment; (3) Identifying social acceptance and legitimacy constraints, (4) Learning, diffusion, and adoption; (5) Implications for Sustainable Development Goals of archetypical mitigation pathways; and 6) Policy options and governance. A crosscutting WP7 synthesizes research along three salient, but under-researched themes: A) Socio-technical change; B) Managing transition risks; and C) Political economy and feasibility of deployment. WP8 focuses on stakeholder engagement, entailing scenario co-design, science-policy dialogue formats, and specific outreach formats for target groups.
Evaluation of a co-product of biodiesel production as carbon source in the production of biosurfactant by P. aeruginosa MSIC02

Abstract This work focuses on the use of a co-product of biodiesel production as carbon and energy source for the production of rhamnolipids by a new strain of Pseudomonas aeruginosa MSIC02. Different carbon sources were compared and the highest rhamnolipid concentration (1269.79 mg/L) was achieved when hydrolyzed glycerin was used. The study of nutritional and environmental conditions allowed an increase in the production of rhamnolipids. Maximum rhamnolipid concentration was attained at 18 g/L of glycerol, 4.0 g/L of NaNO 3 , 62 mM of KH 2 PO 4 , pH 7.0 and 37 °C. Highest product yields on substrate and biomass and productivity were achieved at the same conditions. The biosurfactant showed good emulsifying properties (IE 24  = 65%), being able to form emulsions with mineral and vegetable oils. The NMR spectrum of H 1 and C 13 and mass spectra indicates that the purified product contained two types of rhamnolipids: l -rhamnosyl-β-hydroxydecanoyl-β-hydroxydecanoate (RL1) and l -rhamnosyl l -rhamnosyl-β-hydroxydecanoyl-β-hydroxydecanoate (RL2).
Fourier expansion of Arakawa lifting II: Relation with central L-values

This is a continuation of our previous paper [Fourier expansion of Arakawa lifting I: An explicit formula and examples of non-vanishing lifts, Israel J. Math. 187 (2012) 317–369]. The aim of the paper here is to study the Fourier coefficients of Arakawa lifts in relation with central values of automorphic [Formula: see text]-functions. In the previous paper we provide an explicit formula for the Fourier coefficients in terms of toral integrals of automorphic forms on multiplicative groups of quaternion algebras. In this paper, after studying explicit relations between the toral integrals and the central [Formula: see text]-values, we explicitly determine the constant of proportionality relating the square norm of a Fourier coefficient of an Arakawa lift with the central [Formula: see text]-value. We can relate the square norm with the central value of some [Formula: see text]-function of convolution type attached to the lift and a Hecke character. We also discuss the existence of strictly positive central values of the [Formula: see text]-functions in our concern.
Optimal design of pre-fermentation and fermentation stages applying nonlinear programming

In the present work, the optimal design of pre-fermentation and fermentation operations for ethanol production is obtained developing a superstructure mathematical model. Different configurations of both operations are simultaneously considered in an overall model which also includes detailed kinetics equations. The zero wait is the transfer policy selected for these stages for ensuring the quality of these operations, given the nature and characteristics of microbiological sugary substrates. From the overall proposed model, the optimal configuration of the stages, the number of duplicated units in each stage, the size of each process unit, the process variables as concentrations and flows, and the total investment and production cost are obtained. This model is formulated as a non-linear programming problem, which is solved by the Professional Software, General Algebraic Modeling System (GAMS) with the application of CONOPT solver. The optimal design and operation of pre-fermentation and fermentation stages are obtained and the attained results are compared with the structures in conventional distillery.
Fortalecimiento de la imagen y reputación de la plaza las Américas en la web 2.0, para la fidelización de su público de interés en la ciudad de Quito

This work is focused on the management of Corporate Communication as the key to building an image and reputation that favors the organization axis. Mishandling of image, reputation and channels can cause a breakdown of communication, this is the example of the Plaza Las Americas, where customers have greater participation in events or platforms used by management. The development of the theoretical framework was based on theories of communicators as Cappriotti, Formanchuk, Pizarro, among others, obtaining work methodically in order to improve the image and reputation of the Plaza Las Americas through Web 2.0, for loyalty of its stakeholders in the city of Quito. Multimodal approach was used by research surveys to managers of local belonging to the Plaza and strategic public which was consuming. The interviews were conducted with people who handle communication directly or indirectly from the Plaza las Americas, Communications Manager and BTL, Mary Bastidas and General Manager ALLCOMDER S.A. The results obtained in this study allowed us to understand the relationship-Estate Management-Customers and public perception of the image of Plaza las Americas. As it became known way if the strategic public have knowledge of the communication channels or tools using the square and if you give them some use. The aim of this paper is to contribute to the development of strategies to strengthen ties between the Plaza Las Americas-Public Strategic, seeking improvements in communication channels to ensure the loyalty of its audience.
A precision cell replacement strategy for  parkinson’s disease

Parkinson’s disease (PD) is a progressive incurable neurodegenerative disorder characterized by the loss of substantia nigra neurons (A9/SNs), a subset of midbrain dopaminergic neurons (mDAs) that are required for functional re-innervation of the striatum. Current treatments for PD are symptomatic and do not prevent disease progression. Proof-of-concept clinical studies using human fetal midbrain tissue for transplantation have shown that replacement of mDAs can change the course of PD. Human pluripotent stem cells (hPSCs) are currently used to generate mDAs for cell replacement therapy in clinical trials. However, our single-cell RNA-sequencing analysis of these preparations revealed that they comprise a complex mixture of cell types, including mDAs but also excessive vascular progenitor-like cells and serotonin neurons, thought to drive dyskinesias.
Selective generation of A9/SNs for PD cell replacement therapy remains thus a major challenge. Here I propose to identify how human adult A9/SNs are generated in order to develop a novel cell type-specific precision cell replacement therapy for PD. I hypothesize that a yet undefined network of transcription factors and regulators control A9/SN subtype specification, and that such factors can be used to engineer A9/SNs starting from hPSCs or astrocytes, moving the field beyond the state of the art.
This will be achieved by: 1) Using cutting-edge CRISPR and single cell methodologies to identify the factors controlling the specification of human A9/SNs; and 2) developing two novel cell replacement strategies for PD, involving either transplantation of hPSC-derived progenitors forward-programmed into A9/SNs or reprogramming of endogenous striatal glia in situ into A9/SNs, using a method we recently developed.
I expect PreciseCellPD will generate groundbreaking knowledge of the mechanisms controlling the generation of human A9/SNs and will set the basis of a novel and transformative precision cell replacement therapy for PD
ISOLA BELLA

The general aim of the project ISOLA BELLA is to strengthen the governance of minor islands’ Public Administration in order to transform them from marginal and peripheral communities of the Mediterranean into a “networking” system, able to promote new development models, instruments and strategies based on a participatory decision-making process in order to manage the territory according to the principles of sustainability. Minor islands represent an invaluable resource from the point of view of culture, landscape and business for the entire Mediterranean area. They convey added value to the Mediterranean and have become, at international level, a strong pole of attraction that is increasingly fragmented and diversified in terms of seasons and types of services. The island situation can represent a serious threat for the development of the territories and, if overlooked, it can worsen a socio-economic gap already existing between the costs and the islands. The project’s strategic objectives are therefore: • Fostering the growth of local communities through the creation of a concerted and permanent platform to share development strategies and negotiate good methodological choices; • Increasing the sustainability of actions undertaken by Public Administrations through the development of territorial development models; • Safeguarding and upgrading islands as a sort of “product”, through the activation of innovative information and technological platforms to be used as instruments to support decisions; • Enhancing human resources through training courses, addressed to local people also via Internet and using IT to reduce geographical isolation; • Promoting a common identification of different islands by means of networking and territorial marketing actions in order to offer to the economic and social partnership a reference framework for investments and competition on different quality segments.
Premarital screening for sickle cell haemoglobin: awareness and acceptability among some categories of Health Professionals and Medical Students at the Lagos University Teaching Hospital.

Urinary tract infection (UTI), a significant but preventable cause of morbidity in children, is an important risk factor for development of renal insufficiency. Having simple and reliable means of screening children facilitate its prompt treatment.To evaluate the use of dipstick test for leukocyte esterase (LE) and nitrite as screening tool in the diagnosis of UTI in children.This cross-sectional study was done in the department of Paediatrics, University of Port Harcourt Teaching Hospital (UPTH) from February to October 2005. Children 2 to 15 years with symptoms suggestive of UTI were studied. Midstream urine specimen was collected from each patient forLEtest, nitrite test and culture.Out of 139 children, 72(51.8 percent) males and 67(48.2 percent) females studied, 33(23.7 percent) had positive urine culture. The prevalence of UTI was significantly higher in females than in males (p=0.001). The LE dipstick test correctly identified 17 of the 33 patients with culture proven UTI, with 51.5 percent sensitivity and 79.2 percent specificity. The nitrite dipstick test showed 42.4 percent sensitivity and 93.3 percent specificity. The combination ofLEand nitrite correctly identified 24, giving 73 percent sensitivity and 75.5 percent specificity. The LE seemed to have a higher sensitivity as a screening tool in the diagnosis of UTI than nitrite, but the difference was not statistically significant (p=0.46). However, the combination of LE and nitrite provided a higher sensitivity than either of them with a statistically significant difference (p=0.04). Keywords: Sickle cell anaemia, premarital screening, Haemoglobin genotype.
Linear vs. nonlinear control techniques for a quadrotor vehicle

The aim of this paper is to propose a nonlinear control algorithm that is able to stabilize the attitude and altitude of a quadrotor vehicle, and then to compare it with the classical techniques, such as PID and LQR. The nonlinear algorithm is based on the backstepping methodology integrated with the integral and adaptation schemes. It's called “Adaptive Integral Backstepping Controller” (AIBC). The recursive Lyapunov methodology in the backstepping technique will ensure the system stability, the integral action will increase the system robustness against disturbances and model uncertainties, and the adaptation law will estimate the modeling errors caused by assumptions in simplifying the complexity of the quadrotor model. Furthermore, a quadrotor vehicle is designed and modeled in this paper to perform the controlling task
Iron mineral dynamics in redox-affected soils and sediments: pushing the frontier toward in-situ studies

IRMIDYN will study the dynamics of redox-driven iron mineral transformation processes in soils and sediments and impacts on nutrient and trace element behavior using a novel approach based on enriched stable isotopes (e.g., 57Fe, 33S, 67Zn, 113Cd, 198Hg) in combination with innovative experiments and cutting-edge analytical techniques, most importantly 57Fe Mössbauer and Raman micro-spectroscopy and imaging. The thermodynamic stability and occurrence of iron minerals in sufficiently stable Earth surface environments is fairly well understood and supported by field observations. However, the kinetics of iron mineral recrystallization and transformation processes under rapidly changing redox conditions is far less understood, and has to date mostly been studied in in mixed reactors with pure minerals or sediment slurries, but rarely in-situ in complex soils and sediments. Thus, we do not know if and how fast certain iron mineral recrystallization and transformation processes observed in the laboratory actually occur in soils and sediments, and which environmental factors control the transformation rates and products. Redox-driven iron mineral recrystallization and transformation processes are key to understanding the biogeochemical cycles of C, N, P, S, and many trace elements (e.g., As, Zn, Cd, Hg, U). In face of current global challenges caused by massive anthropogenic changes in biogeochemical cycles of nutrients and toxic elements, it is paramount that we begin to understand and quantify the dynamics of these processes in-situ and learn how we can apply our mechanistic (but often reductionist) knowledge to the natural environment. This project will take a large step toward a better understanding of iron mineral dynamics in redox-affected Earth surface environments, with wide implications in biogeochemistry and other fields including environmental engineering, corrosion sciences, archaeology and cultural heritage sciences, and planetary sciences.
Sustainabiltiy in Tourism and Resource Management

The RFO Sitar - Sustainability in Tourism and Resource Management - focuses on tourism (focus on health-tourism, eco-tourism and culture-tourism) and resource management (focus: renewable energy, waste water management and renewable primary products), sectors that are extremely important for the development, labour markets and gross national product of the participating regions. The partner regions have identified similar problems and challenges such as lack of co-operation between different sectors of the economy, the lack of integration of rural development, cultural offers and tourism services, underdeveloped services and training opportunities. Overall objective / Objectif général The overall objective of SITAR is to prepare the regions to address the challenges of an enlarged EU in the fields of tourism and resource management, improve policies and instruments, stimulate intra- and inter-regional learning processes, develop new approaches, services and products based on existing good practices of the Objective 1, Objective 2 and INTERREG experiences. In light of the Structural Funding after 2006, the results of the RFO should also provide a strong impetus for the development programmes of the participating regions. The exchange of experience and co-operation in health, culture and eco-tourism will lead to more efficient use of the regions' unique selling propositions, co-operation in resource management aims to create and extend regional competencies in the partner regions in the area of resource management and activities in research, education and vocational training will focus on the specific requirements of the partner regions. Expected results / Résultats attendus SITAR will lead to the implementation of at least 20 pilot or demonstration projects and numerous inter-regional meetings, workshops and conferences. It will help strengthen the inter-regional networks between the participating regions and at subproject/regional partnership level. The RFO will result in the transfer of know-how and best practices between the regions, raising the level of professionalism of each region and contributing to cost minimisation through efficient know-how transfer and sustainable co-operation. It will also foster the development of a uniform marketing concept and development of innovative cultural offers and the creation of target-group-oriented offers (integrating local farming) in nature parks.
Unraveling the immune landscape in uveal melanoma

Cancer Immunotherapy is the latest breakthrough in the fight against cancer, especially with the successes of checkpoint inhibitors. However, numerous tumors appear non-responsive, including uveal melanoma (UM) despite its shared cellular origin with cutaneous melanoma. In this project, I propose to study the immune landscape of UM and explore strategies to overcome mechanisms detrimental to the antitumor immune response. I will employ highly innovative technologies from the fields of genomics, immunology and bioinformatics to explore the tumor microenvironment. 
Gene expression profiles of UM metastases and neoantigen presentation will be obtained by RNA sequencing. The functional expression of multiple immune markers will be analyzed by cutting-edge multispectral immunohistochemistry to determine immune cell subset presence in a qualitative and quantitative manner. The obtained knowledge will subsequently be used to test and improve reactivity of tumor-infiltrating lymphocytes in an autologous model. These experiments require optimal expansion of tumor-infiltrating T cells, which is highly developed at the laboratory of prof. Svane at the Center for Cancer Immune Therapy at the Herlev Hospital in Copenhagen, Denmark. I expect that this project will provide a more complete overview of the immune landscape of UM and reveal important mechanisms underlying immune suppression in UM. The findings of this project could pave the way to the clinical development of successful immunotherapeutic strategies for the treatment of UM and potentially other tumor types resistant to immune checkpoint inhibitors. Finally, this project will improve my laboratory and leadership skills, greatly improving my chances of achieving the next goal in my career: a permanent position as an Medical Oncologist with my own lab-based group in the expanding field of Cancer Immunotherapy to accelerate the application of translational research into the clinic.
Assessing vascular endothelial function using frequency and rank order statistics

Abstract Using frequency and rank order statistics (FROS), this study analyzed the fluctuations in arterial waveform amplitudes recorded from an air pressure sensing system before and after reactive hyperemia (RH) induction by temporary blood flow occlusion to evaluate the vascular endothelial function of aged and diabetic subjects. The modified probability-weighted distance (PWD) calculated from the FROS was compared with the dilatation index (DI) to evaluate its validity and sensitivity in the assessment of vascular endothelial function. The results showed that the PWD can provide a quantitative determination of the structural changes in the arterial pressure signals associated with regulation of vascular tone and blood pressure by intact vascular endothelium after the application of occlusion stress. Our study suggests that the use of FROS is a reliable noninvasive approach to the assessment of vascular endothelial degeneration in aging and diabetes.
Youngsters on the move

This project organises an exchange of experiences and work experiments between young people who will work in the tourism business to help increase cross-border worker mobility and develop a communication, collaboration and cross-border governance system indirectly. This project organises and carries out work experiments for young people leaving behind traditional training focused on local food products provided by tourism/commercial businesses. It promotes the development of green tourism and local attractions and helps participants with employment prospects by offering real opportunities for professional growth. These activities add value to cross-border collaboration and promote young people’s professional growth, knowledge and skills beyond Regional and National schemes and settings. The innovative element is in the methodological approach; the Partnership involves effective collaboration between the educational-scholastic system, companies and employment services overturning the usual trend of education preceding business. In this case, companies take the initiative and define shared professional goals for the development of a well-defined economic sector. To this end, they set up a human resources development plan and employ the Chamber of Commerce system to provide a set group of young people with cross-border growth opportunities.