SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Naked mole-rats to mice: metabolic reprogramming to prevent ischaemic injury

The overarching aim of this proposal is to identify unique features of naked mole-rat cardiac metabolism that serve as advantageous adaptations to deal with a hypoxic environment, a state relevant to heart disease. Coronary heart disease is a leading cause of death and its pathogenesis has been linked to metabolic abnormalities. The naked mole–rat has recently emerged as a rodent model of interest to biomedicine due to its extraordinarily long and healthy lifespan (>36 years). Naked mole-rats exhibit various atypical cardiac features including a remodelled metabolism that serve as adaptations to their extremely hypoxic and hypercapnic environment, and also contribute to the negligible decline in heart function with age. I will use “omics” technologies to examine the genetic, epigenetic and post-translational features underlying naked mole-rat rewired metabolism, hypoxia tolerance and myocardial fitness. I have shown that the naked mole-rat can survive extended periods under extreme hypoxia without apparent damage, by switching its metabolism to utilise fructose.  Use of fructose in ischaemic conditions could therefore prove beneficial in other mammals. I will assess whether enhancing fructose metabolism via transgenic mouse models is protective under ischaemic conditions. I have shown that the transcriptional landscape of the naked mole-rat myocardium has preserved several neonatal-like features. Since neonatal mammalian heart has regenerative capacity, a quality that is quickly lost after birth, naked mole-rats may be the first adult mammalian model for heart regeneration. This project will measure regenerative capacity of the adult naked mole-rat heart and the mechanisms by which it may retain its proliferative competency. By introducing these features into the mouse I aim to validate and understand the benefit of these unique traits in promoting a healthy myocardium with possibilities for translating these discoveries into novel therapeutic strategies in man.
Friends-and-native-people-aware approach for Collaborative Filtering

In our daily lives, recommendation plays an important role for generating useful predictions. Recommender systems generate predictions for the users based on their preferences. Collaborative Filtering (CF) is one of the techniques that is widely used by many recommender systems. In order to make the recommendations, CF uses known preferences to generate personal recommendations that suit the user. In this paper, we propose a location-based recommender system called Friends-and-native-people-aware Approach for Collaborative Filtering. The main purpose of our recommender system is to consider only the opinions of friends and of people living in the place where the users wish to go. We only consider friends and native people opinions since friends have the common interests and preferences with the user while native people know good local places or activities to suggest to. By combining those two inputs, we believe that this method will produce better recommendations in terms of a better quality and personalized location recommendation.
Euro South Hub

Euro-South HUB wants to create a research center, a social space, an incubator for project and social enterprise, starting from the experience already maturated in more than 23 cities in the world from which 4 within the Mediterranean basin (http://www.the-hub.net/). The main idea is to create a physical HUB in Ortigia (Siracusa) with a small branch in Lampedusa and two virtual spaces, one for Malta and the other for facilitating the communication between Siracusa, Malta and Lampedusa. The aim is to facilitate the cultural, social and economic promotion of the human patrimony of this sensitive portion of the Mediterranean Sea. Special attention will be paid on connecting the tageted territories with international networks and circuits that look beyond the traditional seasonal tourism. The intention of adopting the HUB philosophy in order to consolidate the vocations and identities of Siracusa (Ortigia), Malta (Valletta), and Lampedusa - especially in their historical centers and in their peculiar condition of last European regions in the South of the Mediterranean - is coherent with the Neighbour Policy of the EU that encourages to develop a growth which instead of being spot-shaped and based on several centers (Messina, Catania, Siracusa, Ragusa, Malta, Lampedusa…) is oriented to create interconnected axles and corridors for sustainable and endogenous local development.
Stability of organic nanowires

The morphological stability of organic nanowires over time and under thermal load is of major importance for
their use in any device. In this study the growth and stability of organic nanowires from a naphthyl end-capped
thiophene grown by organic molecular beam deposition is investigated via atomic force microscopy (AFM). Aging
experiments under ambient conditions already show substantial morphological changes. Nanoscopic organic
clusters, which initially coexist with the nanowires, vanish within hours. Thermal annealing of nanowire samples
leads to even more pronounced morphology changes, such as a strong decrease in nanowire number density, a
strong increase in nanowire height, and the formation of new types of crystallites. This happens even before
sublimation of organic material starts. These experiments also shine new light on the formation process of the
nanowires.
SECURE TRANSPORT CONTAINER FOR THE TRANSPORT OF LOCKBOXES

The invention relates to a device for the transport of a lockbox wherein a portable transport container is made of conductive single or multi-layered material, ensuring an enveloping visual cover of the lockbox. The transport container is characterized both by a flexibility of the materials as well as by a closure device that exposes an opening for acceptance and removal of a lockbox and additionally comprises a second opening for feed-through of the security handle of the lockbox. The invention additionally relates to a method for monitoring and securing the transport of a lockbox by a transport container of this kind.
A PARTICIPAÇÃO DA GESTÃO ESCOLAR NA MOTIVAÇÃO DOS ALUNOS DA EJA ATRAVÉS DA PEDAGOGIA DE PROJETOS

Este estudo é um recorte da minha dissertação de mestrado, realizado na Universidad Interamericana, destaca o papel da gestão escolar na motivação dos alunos da EJA IV da EMEIF - Escola Municipal de Ensino Infantil e Fundamental Antônio Correia Lima, localizada, em Fortaleza-CE. A referida escola realiza uma série de atividades pedagógicas e projetos escolares com o intuito de motivar os alunos e, se não erradicar, pelo menos diminuir os casos de desistência ou abandono. Para tanto, recorre-se a alguns estudos de pesquisadores dessa temática, a exemplo de Paulo Freire, além de artigos disponibilizados na internet, bem como a legislação vigente, mormente à Lei de Diretrizes e Bases da Educação Nacional, lei nº. 9.394/96, e Constituição Federal do Brasil de 1988. A metodologia deste estudo foi baseada em pesquisa bibliográfica e pesquisas de campo, realizada na escola citada, por meio de entrevistas semiestruturadas. Conclui-se, portanto, que a participação da gestão escolar na elaboração e aplicação dos projetos tem sido de fundamental importância, uma vez que se constata que as metodologias de projetos podem influenciar não só no resultado final do curso, como também na ampliação de oportunidades de aprovação dos cursistas, visto que promovem maior interesse e consequentemente maior aprendizado, aumentando, dessa forma, suas respectivas visões de mundo.
Nutritious, safe and sustainable seafood for consumers of tomorrow

SEAFOODTOMORROW aims to validate and optimize commercial solutions for improving the socioeconomic and environmental sustainability of the seafood production and processing industry, while contributing to product quality and safety. Activities will focus on the sustainable production and processing of nutritious and safe seafood products through the demonstration and first application in the market of eco-innovative, sustainable solutions of marine and aquaculture-derived food products and nutrients. The proposal will take into account impacts across different regions and population segments, as well as the specificities of different types of seafood.
Activities will include among others: utilization of agro and seafood byproducts to develop sustainable feeds for aquaculture enabling the production of tailor made products fortified with specific essential nutrients for consumers, assess the feasibility of salt replacers in seafood, validate digestible, attractive, functional and nutritionally adapted seafood for senior people and youths, validate strategies to prevent/remove contaminants from seafood, and optimize sensors and biosensors for the assessment of safety, among others.
The consortium expects strengthening the wider utilization of eco-innovative solutions, as a result of greater user acceptance, higher visibility of these innovative solutions and creation of scalable markets, and increasing the availability of healthier seafood to improve consumers' diet and health. The consortium is built on interdisciplinary research teams of 19 RTDs involved, renowned by its top-quality applied technological development and with strong and cohesive links gathered in previous funded activities (e.g. FP7 ECsafeSEAFOOD), thus anticipating successful outcomes. In addition, 4 IAGs and 13 SMEs with diverse and complementary interests in the solutions under validation and optimization will also integrate the consortium.
Raising knowledge and developing technology for the design and deployment of high-performance power transformers immersed in biodegradable fluids “biotrafo”

The BIOTRAFO project will analyze the effect of temperature on the designs of power transformers that use biodegradable esters as coolant, the environmental and fire performance of these liquids will be also evaluated.
These machines are very common in our power distribution systems. Since electricity is generated until it reaches households, it passes through an average of four transformers. Currently the liquid used in most of these machines is a petroleum derivative, since its good performance is well known. However, the environmental awareness of many companies is demanding new transformers that are cooled by esters of natural origin. In this framework, BIOTRAFO proposes a study that allows to know the temperature in the windings of the transformer when using biodegradable liquids, which by their nature are more viscous. This temperature is a critical factor for the useful life of the transformer, due to the aging of dielectric solid materials. The aging of these materials when immersed in these liquids will also be analyzed. Not only the question will be observed from a theoretical perspective, industrial platforms will also be used to test the generated models.
The results of the research will be disseminated among specialized and non-specialized audiences, considering the commercial exploitation of the results obtained. The project will also carry out tasks of knowledge transfer generated for this purpose, the training aspects of the research personnel involved in the project will be taken care of.Finally, the management and coordination of the project will be efficiently organized.
To carry out this task, a consortium of thirteen partners has been formed, six of which do not belong to the EU. All of them have knowledge and proven experience in the field of study. Ten of the partners belong to the academic sector and three are companies. Two are manufacturers of power transformers, while the other performs diagnostic work on transformers that are in operation
Congenital fibrovascular pupillary membrane

These eyes are usually treated with a membranectomy and pupilloplasty with or without a lensectomy. After fulfilling the anterior chamber with the viscoelastic, the pupil was mechanically distended and subsequently the fibrovascular membrane was resected (sphincterectomy was not required). For patients who require only membranectomy, it is important to be careful as not to cause traumatic cataract, by accidently touching the anterior capsule of the crystalline. In the postoperative period, the left eye was treated with prednisolone acetate 1% and cyclopentolate chloridrate 1% eyedrops. Crystalline lenses remained clear on both eyes. Posterior to that, glasses were prescribed and occlusion antisupressive therapy in partial time, of contralateral eye.
A quantitative solid-state Raman spectroscopic method for control of fungicides

A new analytical procedure using solid-state Raman spectroscopy within the THz-region for the quantitative determination of mixtures of different conformations of trifloxystrobin (EE, EZ, ZE and ZZ), tebuconazole (1), and propiconazole (2) as an effective method for the fungicide product quality monitoring programmes and control has been developed and validated. The obtained quantities were controlled independently by the validated hybrid HPLC electrospray ionization (ESI) tandem mass spectrometric (MS) and matrix-assisted laser desorption/ionization (MALDI) MS methods in the condensed phase. The quantitative dependences were obtained on the twenty binary mixtures of the analytes and were further tested on the three trade fungicide products, containing mixtures of trifloxystrobin-tebuconazole and trifloxystrobin-propiconazole, as an emissive concentrate or water soluble granules of the active ingredients. The present methods provided sufficient sensitivity as reflected by the metrologic quantities, evaluating the concentration limit of detection (LOD) and quantification (LOQ), linear limit (LL), measurement accuracy and precision, true quantity value, trueness of measurement and more.
Sensitization of enteric neurons to morphine by HIV-1 Tat protein

Gastrointestinal (GI) dysfunction is a major cause of morbidity in acquired immunodeficiency syndrome (AIDS). HIV-1-induced neuropathogenesis is significantly enhanced by opiate abuse, which increases proinflammatory chemokine/cytokine release, the production of reactive species, glial reactivity, and neuronal injury in the central nervous system. Despite marked interactions in the gut, little is known about the effects of HIV-1 in combination with opiate use on the enteric nervous system.To explore HIV-opiate interactions in myenteric neurons, the effects of Tat ± morphine (0.03, 0.3, and 3 μM) were examined in isolated neurons from doxycycline- (DOX-) inducible HIV-1 Tat(1-86) transgenic mice or following in vitro Tat 100 nM exposure (>6 h).Current clamp recordings demonstrated increased neuronal excitability in neurons of inducible Tat(+) mice (Tat+/DOX) compared to control Tat-/DOX mice. In neurons from Tat+/DOX, but not from Tat-/DOX mice, 0.03 μM morphine significantly reduced neuronal excitability, fast transient and late long-lasting sodium currents. There was a significant leftward shift in V(0.5) of inactivation following exposure to 0.03 μM morphine, with a 50% decrease in availability of sodium channels at -100 mV. Similar effects were noted with in vitro Tat exposure in the presence of 0.3 μM morphine. Additionally, GI motility was significantly more sensitive to morphine in Tat(+) mice than Tat(-) mice.Overall, these data suggest that the sensitivity of enteric neurons to morphine is enhanced in the presence of Tat. Opiates and HIV-1 may uniquely interact to exacerbate the deleterious effects of HIV-1-infection and opiate exposure on GI function.
STRATEGI PENGEMBANGANEKOWISATA BERBASIS MASYARAKATDI DISTRIK MEOS MANSAR KABUPATEN RAJA AMPAT

Special Autonomy in West Papua Province offers strategic opportunities
for the acceleration of local community-based development. The program provide
Local Government with great autonomy to explore local resources to improve the
local community welfare, including through ecotourism development. Therefore,
the purpose of this study is to find out ecotourism development strategies in Raja
Ampat Regency, West Papua Province.
The study was conducted by using a descriptive qualitative method with a
case study approach. Locactions of the study were five villages, i.e. Yenbuba, Sawinggrai,
Saundarek, Yenwaupnor, and Arborek in Meos Mansar District, Raja
Ampat Regency. Data used in the study were primary data obtained by using interview,
while secondary data obtained by using documentary technique. The data
collected were analyzed by using the SWOT-based qualitative technique.
Result of the study indicates that Raja Ampat Regency has great potentials
to be developed as ecotourism object and attraction. The dimension of SWOT in
ecotourism development in the five villages of Meos Mansar District Raja Ampat
Regency with the highest score was Opportunity (5,142), followed by Strenght
(4,025), Weakness (3,586), and Threat (3,496). Based on the results, Government
of Raja Ampat Regency should emphasize Strenght and Opportunity Dimensions
with the highest scores as the main bases of the ecotourism development strategy
formulation. The priorities of the tourism development performed by Government,
particularly in the five tourism villages of Meos Mansar District, were as follows:
to issue policy and regulation on the utilization of protected or conservation forest
resource through ecotourism investment, which is simultaneously performed with
marine ecotourism and based on governmentâ��s commitment to vision, mission,
and natural tourism development strategy. Priority was also given to utilization of
see grass and coral reefs in coastal environment, mangrove forest area around the
five villages for the beauty of coastal nature, and the interesting plain islands to
tract while enjoying the natural panorama and traditional settlement as ecotourism
object and attraction. Finally, government should also intensify the development
of ecotourism together with local community to maintain mangrove forest around
the five villages and did not log them.
GNSS measurements for ground deformations detection around offshore natural gas fields in the Northern Adriatic Region

Abstract. The study aims to evaluate ground deformations in a vast area characterized by the coexistence of intense anthropic activities and offshore natural gas production. Onshore subsidence can be studied by GNSS, InSAR, high precision leveling and extensometers that provide broad datasets for a fully integrated description of the phenomenon. At present, seafloor subsidence monitoring cannot be carried out by high precision leveling, and GNSS is the only reliable method, implemented by means of permanent stations installed on offshore hydrocarbon production facilities. In the Northern/Central Adriatic Sea gas production platforms, GNSS data are recorded since more than 15 years, allowing to estimate not only the average subsidence of the platform/seafloor, but also possible velocity variations due to underground fluids withdrawal. This study shows the comparison of 22 offshore GNSS permanent stations located in the study area. Raw data have been processed with two different software packages (GIPSY-OASIS and GAMIT-GLOBK) based on different approaches and considering different boundary conditions of geodetic and/or modeling nature. Main results point out the high accuracy of the GNSS technology considering also the impact of data processing. Finally, at selected permanent stations we also performed a comparison of results obtained by GNSS, InSAR and high precision leveling.
STRESS AND LOAD VARIATION DETECTOR

A method and apparatus to detect variations in load by comparing signals related to, but not necessarily accurately correlated with, stress/strain states of a load transmitting member. In one embodiment, a first signal (30) is obtained relating to the time rate of change of stress in the member produced by a first loading event or series of events. A second signal (34) is obtained which relates to the time rate of change of stress in the member produced by a second loading event or series of events. The first and second signals are compared (40) to detect significant variations (42) in loading. Each of the two signals may be a composite of other signals. A magnetostrictive sensor may preferably be used to obtain the signals relating to the stress in the load transmitting member. The load may be applied force, stress, strain, or deflection. Environments for use include brake pedal and suspension system.
From barren to beautiful: A pattern-matching localization scheme integrating heterogeneous network data

Among all the wireless localization techniques, the Wi-Fi pattern-matching scheme is one of the most widely used approaches, which estimates the user's location by comparing his/her device's received signal strength (RSS) against a pre-trained radio map on the fly. The pattern-matching solutions have an inherent drawback: the expensive calibration operation of war-driving. In order to reduce the calibration operation cost of war-driving, many solutions based on the community approach have been proposed [1]-[3], which collect the Wi-Fi training data from users' contributions. However, most works only consider the Wi-Fi patterns. For the heterogeneous training data, such as a radio map combined signals from both Wi-Fi and cellular networks, a method shows how to collect and exploit the data through an ongoing way is still missing. In this paper, our objective is to grow a heterogeneous radio map from barren to beautiful over a large area, such as a regional area or a national area. Based on the concept of community approach, we propose a geography-based method to combine the cellular and the Wi-Fi radio maps. We believe that our framework can provide a valuable solution for pattern-matching localization which shows how to effectively build a radio map and quickly estimate the user's location with acceptable distance errors.
Effects of phosphate and thiosulphate on arsenic accumulation in the species Brassica juncea

Arsenic (As) is recognized as a toxic pollutant in soils of many countries. Since phosphorus (P) and sulphur (S) can influence arsenic mobility and bioavailability, as well as the plant tolerance to As, phytoremediation techniques employed to clean-up As-contaminated areas should consider the interaction between As and these two nutrients. In this study, the bioavailability and accumulation of arsenate in the species Brassica juncea were compared between soil system and hydroponics in relation to P and S concentration of the growth substrate. In one case, plants were grown in pots filled with soil containing 878 mg As kg(-1). The addition of P to soil resulted in increased As desorption and significantly higher As accumulation in plants, with no effect on growth. The absence of toxic effects on plants was likely due to high S in soil, which could efficiently mitigate metal toxicity. In the hydroponic experiment, plants were grown with different combinations of As (0 or 100 μM) and P (56 or 112 μM). S at 400 μM was also added to the nutrient solution of control (-As) and As-treated plants, either individually or in combination with P. The addition of P reduced As uptake by plants, while high S resulted in higher As accumulation and lower P content. These results suggest that S can influence the interaction between P and As for the uptake by plants. The combined increase of P and S in the nutrient solution did not lead to higher accumulation of As, but enhanced As translocation from the root to the shoot. This aspect is of relevance for the phytoremediation of As-contaminated sites.