SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Feasibility assessment of a cloud application platform for rational drug design using high throughput molecular dynamics

The pharmaceutical industry’s increasing spending on R&D is not translating into new and better drugs at the pace required to maintain competitiveness. In-silico computational methods are beginning to gain traction in the progress towards more rational drug discovery workflows. Among the methods available, molecular dynamics (MD) provides the most accurate and useful description of molecular interactions, but the current state of the art has both a high degree of unnecessary technical complexity, and is computationally expensive. 
Together, these two factors have produced a high barrier to entry that substantially limits research productivity.Acellera looks to address these issues by proposing a cloud application platform for high-throughput MD (HTMD) simulations.  This computational platform combines proprietary simulation technology - optimized for speed and simulation throughput – and user-friendly interfaces in a cloud environment to provide a novel resource for drug candidate identification.  HTMD, which allows understanding with an unprecedented degree of resolution and accuracy how drugs interact with their biological targets, can significantly reduce the cost of pre-clinical research (PCR) by virtualizing key steps. 
 It is currently estimated that pharmaceutical companies invest approximately 1000M Euro per approved drug.  As a global leader in the development of technology for high-throughput molecular dynamics, Acellera is uniquely positioned to bring this disruptive computational technology to the market. The HTMD platform is ready for prototyping in an operational environment (TRL 6).  
Acellera proposes a Phase 1 SME Instrument to support the execution of a feasibility study into the market viability of the HTMD solution for pre-clinical research. Results of the study will be used to inform preparations for a larger-scale demonstration in Phase 2 and for the subsequent market launch.
Enantioselective nickel-catalyzed trans-carbometallative couplings and cyclizations

This Fellowship application unites an Experienced Researcher from India (but currently based in Taiwan) with expertise in asymmetric synthesis and transition metal catalysis using gold, silver, and rhodium complexes, with an internationally recognized Host Laboratory in the UK with expertise in the development of new catalytic reactions for organic synthesis. This project will:
• Provide high-quality, structured training for an outstanding scientist with an excellent publication record who is destined for an independent research career, by complementing and enhancing his competencies.
• Showcase European excellence in homogeneous catalysis and organic synthesis, which are critically important branches of chemistry that underpin many sectors, such as the pharmaceutical, fine chemicals, agrochemical, materials, and biochemical industries.
The proposed research is based upon a new synthetic method recently discovered in the Host Laboratory that relies upon the formal trans-carbometallation of organonickel species across an alkyne. The resulting alkenylnickel species can be trapped by various electrophiles in cyclizations that would otherwise be impossible, giving densely functionalized carbo- and heterocyclic scaffolds. Moreover, the products can be obtained with high enantioselectivities using a chiral ligand. We believe this chemistry carries enormous potential, and the final result will be a powerful synthetic method for the preparation of valuable building blocks as single enantiomers. This Fellowship will therefore help Europe to remain globally competitive in the chemical sciences.
Population Carrying Capacity of Cultivated Land Based on Production Capacity in Fujian

This paper constructed the calculating method of population carrying capacity by the fieldwork which was based on the accounting of production capacity in the three consumption levels: subsistence, comparatively well-off and surplus, and scientifically calculated the theoretical, achievable and actual population carrying capacity of cultivated land of Fujian Province in 2010 and 2020 by this method. The results showed that the theoretical production capacity of Fujian could meet the food consumption demands in subsistence, comparatively well-off and surplus, but the achievable and actual production capacity can' t meet the food consumption requires in surplus in 2010. The theoretical population carrying capacity of Fujian cultivated land still has some potential, but the achievable and actual population carrying capacity will be overloaded in 2020.
Platonic Hyperbolic Monopoles

We construct a number of explicit examples of hyperbolic monopoles, with various charges and often with some platonic symmetry. The fields are obtained from instanton data in four-dimensional Euclidean space that are invariant under a circle action, and in most cases the monopole charge is equal to the instanton charge. A key ingredient is the identification of a new set of constraints on ADHM instanton data that are sufficient to ensure the circle invariance. Unlike for Euclidean monopoles, the formulae for the squared Higgs field magnitude in the examples we construct are rational functions of the coordinates. Using these formulae, we compute and illustrate the energy density of the monopoles. We also prove, for particular monopoles, that the number of zeros of the Higgs field is greater than the monopole charge, confirming numerical results established earlier for Euclidean monopoles. We also present some one-parameter families of monopoles analogous to known scattering events for Euclidean monopoles within the geodesic approximation.
CHINESE GAY BEAR MEN

Gay bear studies all have been done by Western researchers and involve Western populations. Comparable studies on non-Western cultures are lacking. Preliminary quantitative and qualitative studies were undertaken to explore Chinese gay bears’ physical and psychological characteristics, as well as personal needs related to and cultural perspectives on Chinese gay bear identity. Quantitative data (N = 646) suggest Chinese gay-bear-identified men, as compared to non-gay-bear-identified gay men, are heavier, hairier, and more masculine traits, and have a higher likelihood of feeling more confident in gay bear community life than in the heterosexual world. Qualitative data ( N = 12) found Chinese gay bears desired to become popular, achieve higher status, and gain emotional attachment in gay bear community. Discussion covers cultural aspects including collectivism, binarism, and exam-oriented education.
AIR PRESSURE RESPONSIVE SWITCH FOR VEHICLE TIRE AND THE LIKE WITH HINGED CONTACT AND DIAPHRAGM

The switch body has an axial opening in one end thereof and a transverse apertured wall at the inner end of the opening. A transverse resilient diaphragm is mounted adjacent to and spaced from the transverse wall whereby to define therewith a chamber. A first electrical contact member is spaced from the diaphragm in opposed relation to the transverse wall, and a second electrical contact member comprising an annular ring portion and an integrally hinged central contact portion is mounted intermediate the diaphragm and the first contact member. The central contact portion of the second contact member is movable with the diaphragm into and out of engagement with the first contact member in response to the air pressure in the chamber.
COMPOUNDS AND METHODS FOR TREATMENT OF AMYLOID-BETA-PEPTIDE RELATED DISORDERS

The present invention relates to compounds, preparation and uses thereof, particularly in the pharmaceutical industry. The present invention discloses novel compounds more particularly useful for the treatment of Alzheimer's disease and other similar diseases, and more specifically the inventive compounds modulate (in particular, inhibit) the level of amyloid-ß peptide (Aß) exhibited by cells or tissues; Aß peptide is a major component of the amyloid plaques found in the brains of Alzheimer's sufferers. This invention also relates the use of these inhibitors to prevent, treat or ameliorate the symptoms of Alzheimer's disease or any Amyloid-ß-Peptide Related Disorder.
Intervenção online com professores para prevenção e enfrentamento do bullying escolar

No Brasil, os estudos sobre o bullyng têm aumentado na última década, mas poucos são direcionados ao preparo do professor para a prevenção e enfrentamento ao bullying. Este estudo teve como objetivo avaliar a viabilidade de uma intervenção online com professores na prevenção e enfrentamento do bullying escolar, com seis sessões semanais grupais, formato multicomponente e metodologia experiencial com as temáticas: concepções de bullying, gerenciamento de conflitos, empatia, comunicação assertiva, autocontrole emocional e autocuidado. Participaram do estudo doze professores (11 sexo feminino e 01 masculino) de escolas públicas da região metropolitana de Porto Alegre, com idades entre 39 e 62 anos. Trata-se de um estudo de viabilidade, com avaliação de processo e avaliação pós-intervenção. Os resultados demonstram a importância de intervenções para professores sobre o tema bullying que promovam a sensibilização quanto à necessidade de prevenção e de estabelecimento de relações positivas no ambiente escolar.
Performance and reliability concern scheme for efficient garbage collection and wear leveling on flash memory-based solid state disk

In the near future, data is expected to double in every two years, which translates to more than one terabyte of data for every person on earth. The difficulty of storing and fetching required data from data centers and servers will consequently increase. As a result, significant attention has been given to the flash memory-based solid state drive (SSD) from consumer electronics companies, which has begun to replace the existing hard disk drive and is highly likely to be used as a storage unit for most of consumer electronics to achieve low power consumption. In contrast to traditional disk, SSD uses semiconductor chips to store data. This structure enjoys original technical characteristics, including low power consumption, shock resistance, and high performance in random access. Such features can overcome the shortcomings of magnetic disks. However, flash memory, the basic unit of SSD, has many distinctive characteristics that cause various challenges. Flash memory does not support updating in the place method. A write operation can be performed only on an empty or erased unit, making the process more time-consuming. Moreover, each storage unit has a limited number of erase cycles, after which the block becomes invalid. This research proposes a new scheme called performance and reliability concern to increase the reliability and performance of SSDs. The eligibility of the proposed scheme is proven through EagleTree simulator. The scheme is also compared with other state-of-the-art techniques in terms of effectiveness and efficiency. Experimental results show that the proposed scheme provides sufficient performance and reliability for SSD.
Photodegradation in natural waters of nitrosamines and nitramines derived from CO 2 capture plant operation

Abstract Amine solvents used in post combustion CO2 capture (PCCC) plants react with NOx, forming carcinogenic nitrosamine and nitramine compounds. These can be emitted to the atmosphere, undergoing deposition to aquatic and terrestrial environments. In the current study, the hydrolytic and photolytic degradation of nine nitramines and nitrosamines identified as possible degradation products of 2-monoethanolamine and piperazine solvents are studied. Nitrosamines and nitramines are generally resistant to hydrolysis, although nitrosopiperazine and piperazine nitramine both undergo up to 50% degradation at 50 °C and pH 7, but not at lower temperatures or other pH values. Owing to absorbance at ∼340 nm, the nitrosamines degrade rapidly in aqueous solution when exposed to sunlight (half-lives in the range 6–11 min), whilst nitramines are photolytically stable. Light screening by natural organic matter (1–100 mg/L) lead to an ∼3-fold decrease in nitrosodiethanolamine (NDELA; 1 mg/L) degradation rate. A theoretical study indicates environmentally relevant concentrations of NDELA may be persistent due to competition with NOM for photons. The main photodegradation products are identified for each nitrosamine, and degradation mechanisms suggested.
WIND TURBINE BLADE TIP SHAPES

A blade for a wind turbine includes a chord of length "c" positioned with a leading edge tip chord angle and trailing edge tip chord angle of between approximately 45 and 75 degrees; a tip having a shear web plane radii distribution in the ranges of L/c (%) R/c (%) 0-10% 1.03-3.68% 30-40% 2.91-5.79% 60-70% 1.77-2.5% 90-100% 0.229-.350% where "L/c" is a range of an approximate normalized location along the chord line expressed as a percentage of the chord length from a leading edge of the blade; and where "R/c" is a range of an approximate nornalized shear web plane tip radius expressed as a percentage of the chord length, for each normalized location L/c.
Promotion of Resource Efficiency in SMEs in Central Europe

Resource efficiency means to use the Earth's limited resources in a sustainable manner while minimising impacts on the environment.  The European Union must use natural resources in a more convincing manner and the answers must go beyond existing policy actions. The situation within the central Europe area is even more alarming, since productivity in most of the countries joining the EU after 2004 has remained static or even decreased. Two major barriers for exploiting the potential for resource efficiency in products and production processes can be identified. First, enterprises and especially SMEs are not aware of their resource utilization, real costs of pollution and the related (cost) reduction potential as well as ways on how to improve the situation. Secondly, SMEs have problems in financing necessary investments in eco-innovations in order to exploit their potential to increase resource efficiency.

The potential for increased resource efficiency, especially targeted at SMEs, will be in the focus of the project PRESOURCE. It aims at increasing resource efficiency in the production sector of central Europe by promoting transnational incentives for eco-innovations.
Effect of Eu Doping on the Structural, Electrical, and Dielectric Properties of K0.5Na0.5NbO3 Ceramics for High-Temperature Capacitor Applications

The structural and dielectric properties of Eu-doped K0.5Na0.5NbO3 (KNN) ceramics were investigated as a potential candidate for use in high-temperature capacitors with working temperature beyond 200°C. x-Ray diffraction results showed that tetragonal and cubic structure distortions occurred for low- and high-concentration doping, respectively. With increase of Eu content, the dielectric anomaly of the tetragonal–cubic transition was depressed and shifted to low temperature, while the temperature of the orthorhombic–tetragonal transition remained unchanged. A dielectric relaxation associated with oxygen vacancies was detected in the paraelectric phase region. The activation energy of oxygen vacancies depended on the Eu concentration and the defect compensation mechanism. KNN doped with 3 mol% Eu (KNN3Eu) showed good dielectric temperature stability (±10%) with relatively high permittivity (>1800 at 225°C) over the temperature range from 119°C to 495°C, representing a good starting point for development of high-temperature capacitor materials.
MEDICINAL AMBROSIA PLANT EXTRACTS

Phytoceutical compositions from organic extracts of the Ambrosia maritima or Ambrosia hispida plants and uses thereof for treatment of cancers is described.
METHOD OF TRANSPORTING AND DISPOSING OF AN OFFSHORE PLATFORM JACKET

A method is disclosed for disposing of an offshore platform jacket (8) by suspending the jacket in one piece under a tow vessel (10), towing it to the disposal site and releasing the jacket at the disposal site. Once the jacket foundation piles have been severed, the first end of the jacket (8) is lifted using a derrick barge crane or winch (31) connected to a first lift rigging means (20) until the first lift rigging means engages with a first release means (12). The second end is lifted in a similar manner. The lift rigging means include a spreader bar (22) having at least one skid shoe (24) attached thereto, at least two padeyes (23) attached at opposite ends of the spreader bar (22), a lift sling (28) attached to the padeyes and at least two jacket support slings (21). Each release means is attached to the vessel (10) and includes at least one rocker beam (14) with a connector (16) being disengaged for allowing each rocker beam (14) to pivot and the jacket to be released at the disposal site.
Distinguishing between Web Attacks and Vulnerability Scans Based on Behavioral Characteristics

The number of vulnerabilities and reported attacks on Web systems are showing increasing trends, which clearly illustrate the need for better understanding of malicious cyber activities. In this paper we use clustering to classify attacker activities aimed at Web systems. The empirical analysis is based on four datasets, each in duration of several months, collected by high-interaction honey pots. The results show that behavioral clustering analysis can be used to distinguish between attack sessions and vulnerability scan sessions. However, the performance heavily depends on the dataset. Furthermore, the results show that attacks differ from vulnerability scans in a small number of features (i.e., session characteristics). Specifically, for each dataset, the best feature selection method (in terms of the high probability of detection and low probability of false alarm) selects only three features and results into three to four clusters, significantly improving the performance of clustering compared to the case when all features are used. The best subset of features and the extent of the improvement, however, also depend on the dataset.
Laser-Induced vapour nanobubbles for intracellular delivery of nanomaterials and treatment of biofilm infections

Lasers have found widespread application in medicine, such as for photothermal therapy. Gold nanoparticles (AuNPs), are often used as enhancers of the photothermal effect since they can efficiently absorb laser light and convert it into thermal energy. When absorbing intense nano- or picosecond laser pulses, AuNPs can become extremely hot and water vapor nanobubbles (VNBs) can emerge around these particles in tissue. A VNB will expand up to several hundred nm until the thermal energy from the AuNP is consumed, after which the bubble violently collapses, causing mechanical damage to neighbouring structures. In this project the aim is to make use of the disruptive mechanical force of VNBs to enable highly controlled and efficient delivery of macromolecules and nanoparticles in cells and biofilms. First, optical set-ups and microfluidics devices will be developed for high-throughput treatment of cells and biofilms. Second, VNBs will be used to achieve efficient cytosolic delivery of functional macromolecules in mammalian cells by cell membrane perforation or by inducing endosomal escape of endocytosed nanomedicine formulations that are functionalized with AuNPs. These concepts will be applied to tumorigenesis research, generation of induced pluripotent stem cells and modulation of effector T-cells for adoptive T-cell anti-cancer therapy. Third, contrast nanoparticles for cell imaging will be delivered into the cytosol of mammalian cells through VNB induced cell membrane perforation. This will enable more reliable in vivo imaging of labelled cells, labelling of subcellular structures for time-lapse microscopy and intracellular biosensing. Finally, [... confidential...] laser-induced VNBs will be used [... confidential...] for improved eradication of biofilms. This concept will be applied to biofilm infections in dental root canals and chronic wounds.
Teratogenic Potential of Garbha Chintamani Rasa in Wistar Albino Rats with focus on physical and behaviour changes.

Teratogens are the substances that may produce physical or functional defects in the human embryo or after the pregnant woman exposed to the substance. Exposure to the teratogenic drugs affects the foetus or embryo in a variety of ways, such as the duration of exposure, the amount of teratogenic substance, and the stage of development the embryo or foetus is in during the exposure. Teratogens may affect the embryo or foetus causing physical malformations, problems in the behavioural or emotional development of the child, and decreased intellectual quotient (IQ) in the child. The present study was carried out to assess the teratogenic potential of Garbhachintamani Rasa in Wistar albino rats based on physical and behaviroal abnormalities. The experiment was designed in such a way that the conformed pregnant rats were selected and administered with Garbhachintamani Rasa for 21 consecutive days. The delivered pups were assessed for teratogenicity based on the physical and behavioural parameter in a set of behaviroal tests such as open field test, rota rod and swimming test at different developing periods. The results showed that, there was significant physical and behavioural alteration in the test drug administered at higher dose level as compared to normal control. Thus it can be concluded that the test drug GCR at therapeutic dose showed well tolerated and nearly normal behavioral pattern, whereas at higher dose it can cause behavioral abnormalities in pups.
The incidence and surgical management of paratubal cysts in a pediatric and adolescent population

The aim of this study is to determine the incidence of paratubal cysts (PTCs) in a pediatric and adolescent population.An institutional review board-approved retrospective chart review was performed between the years of 1998 and 2008 at a single children's hospital. Inclusion criteria were met if pathology reports demonstrated diagnosis of PTC, hydrosalpinx, or hydatid of morgagni.One hundred ten patients had confirmed diagnoses of hydatid of morgagni, hydrosalpinx, or PTC. The incidence of PTCs was 7.3%. Mean age of PTC diagnosis was 13.7 ± 2.82 years, with 12.6% diagnosed premenarchal. Mean age menarche was 11.7 ± 1.34 years among pubertal females. The age of menarche and diagnosis of PTC correlated (Pearson, 0.54) (P < .0001). There was a small correlation between body mass index and size of PTC (r = 0.36; P ≤ .001).The incidence of PTCs was 7.3% in this pediatric and adolescent population. In addition, this is the first study to confirm presence of PTCs in prepubertal females. Surgeon should be aware of these benign cysts because they are frequently a source of abdominal pain in young girls. As nonphysiologic cysts, these will not resolve spontaneously and may increase in size and/or be at risk for adnexal torsion. Ultimately, surgical management is required for definitive resolution.