SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Role of high dose rate brachytherapy in the treatment of prostate cancer

High dose rate (HDR) brachytherapy in intermediate and high-risk prostate cancer patients has started in the late eighties in Europe and the United States, as a boost combined with external beam radiation therapy, as an attractive method for dose escalation. The results of the first dose-escalation study performed at William Beaumont Hospital has established the safety and efficacy of this combined treatment approach. Likewise, this landmark study enabled a paradigm shift in the radiobiology of prostate cancer, demonstrating that the alpha/beta of prostate cancer was much lower than previously believed to be and therefore the sensitivity of this tumor model to higher-than-conventional doses per fraction led to a dramatic increase of hypofractionated treatment regimens, the object of significant clinical research efforts, currently under way. The excellent toxicity profile and clinical outcome of HDR boost combined treatment prompted investigators to expand HDR brachytherapy indications to low/intermediate prostate cancer patients as the sole treatment modality. The results, toxicity and a brief review of the literature for both HDR boost and HDR monotherapy will be presented.
Recent situation on aflatoxins contamination in selected agricultural commodities in Thailand

Mycotoxins are substances produced by certain strain of fungi and they come into the picture on the negative side of food availability and consumption. Among them, the aflatoxins are the most well known and can occur in many valuable products from plant origin, such as peanut products, job’s tear, hairy basil seed, dried chili, etc.. One aspect that all these products have in common is that they are produced mainly in regions with warm and high humidity climate. Thailand is one of the world leading agricultural suppliers and is located in the tropical zone with the hot and high humidity climate so the contamination of aflatoxins is an unavoidable problem and must be overcome. In the last 5 years, Thailand received the notifications from the importing country on the over-legislation limits of aflatoxins contamination in several agricultural commodities, i.e. peanut products, hairy basil seed, Job’s tear and dried chili. Therefore it is necessary to set up the prevention and control measure of aflatoxins and to provide the mechanism on the establishment of inspection and certification system. The “From Farm to Table” concept as well as “The Food Safety Roadmap” is the “must do” issue by The Department of Agriculture as the main department under The Ministry of Agriculture and cooperatives which is directly responsible for the food safety strategies mainly on crops in order to control the agricultural commodity so as to meet standard for the sake of safety as well as to comply with international obligation.
Artificial neural network forward modelling and inversion of electrokinetic logging data

An artificial neural network method is proposed as a computationally economic alternative to numerical simulation by the Biot theory for predicting borehole seismoelectric measurements given a set of formation properties. Borehole seismoelectric measurements are simulated using a finite element forward model, which solves the Biot equations together with an equation for the streaming potential. The results show that the neural network method successfully predicts the streaming potentials at each detector, even when the input pressures are contaminated with 10% Gaussian noise. A fast inversion methodology is subsequently developed in order to predict subsurface material properties such as porosity and permeability from streaming potential measurements. The predicted permeability and porosity results indicate that the method predictions are more accurate for the permeability predictions, with the inverted permeabilities being in excellent agreement with the actual permeabilities. This approach was finally verified by using data from a field experiment. The predicted permeability results seem to predict the basic trends in permeabilities from a packer test. As expected from synthetic results, the predicted porosity is less accurate. Investigations are also carried out to predict the zeta potential. The predicted zeta potentials are in agreement with values obtained through experimental self potential measurements.
Generating a targeted, brain-permeable and stable polymeric nanoparticle for systemic gene delivery to glioblastoma

Glioblastoma multiforme (GBM) is the most prevalent deadly brain tumour and is currently incurable. Patients die from recurrent tumours that grow from cells surviving the first round of treatment. This is mainly due to the narrow therapeutic window of current drugs and to the low permeability of these drugs across the blood-brain barrier (BBB). Targeted non-viral delivery systems have shown great promise to decrease side effects of therapeutics and to enable the transport across biological barriers. The main objective in this proposal is to generate a dually targeted nanoparticle loaded with mRNA encoding a conditionally toxic protein to treat brain cancer. The nanoparticle will be modified with two ligands: an antibody for targeting tumour cells and a peptide that enables transport across the BBB. In addition, I will develop an acid-labile coating that enhances the stability of the polyplex in blood and is released upon internalization. This coating will present the ligands in a defined orientation using bioorthogonal chemistry, thereby maximising their targeting efficiency. The chemical handles will be introduced using genetic code expansion in the antibody and solid-phase synthesis in the peptide.  A variety of formulations will be screened in vitro to evaluate their stability and transfection efficiency, and BBB permeability will be assessed in a human cell-based BBB model. Subsequently, the efficacy of the most promising candidates will be tested in a GBM mouse model. The combination of a polyplex having high transfection efficiency with a sheddable coating and oriented targeting ligands is designed to generate the first efficient non-viral gene delivery system for the systemic treatment of GBM, reaching all tumour cells to provide a more efficient treatment and potentially prevent recurrence.
Use of native plants for ornamental purposes to conserve plant biodiversity: Case of study of Majella National Park

Abstract The Majella National Park in Italy, through its ex situ plant conservation facilities (seed bank, botanical gardens and nurseries) plays an important role in preventing biodiversity loss, especially those rare and endemic species. Among the various conservation strategies, the Park developed a useful way to increase ex situ collections through a nursery chain and selling/giving indigenous species to the local people and community also for ornamental purposes. To date, more than 500 individuals of indigenous species are given every year. This spread of native plants contributes to the diffusion of the rare and endemic species in the protected area and its surroundings enhancing their survival chances.
Manufacturing process for cold-chain independent virosome-based vaccines

MACIVIVA is a highly interdisciplinary consortium among well established and innovative SMEs with scientific excellence and complementary industrial world-leading experts with unique expertise and know-how in virosome technology, spray and freeze drying, large scale manufacturing and packaging. MACIVIVA will pave the path to other large scale thermostable nanopharmaceuticals products for therapeutic and prophylactic vaccines and other potential applications for direct application by non-invasive routes.
Liquid products are inherently prone to physical and/or chemical modifications and degradations. Solid vaccine dosage formats (e.g. powder) may prevent molecular motion and shear-induced degradation, and slow down degradation involving water and oxygen radicals, resulting in improved stability and enhanced shelf-life of vaccines. The cold chain storage is still fundamental for preserving the bioactivity of most liquid and freeze-dried vaccines, and a reconstitution step prior to administration is required for freeze dried vaccines that are usually administered intramuscularly or subcutaneously. These reconstituted freeze dried vaccines harbor important instability and must be used within hours and kept refrigerated. Because most liquid and reconstituted freeze-dried vaccines are susceptible to degradations, it may affect the immunological properties of the immunogens, with unwanted immune responses or insufficient immune protection. 
For addressing liquid virosome-based vaccine instability and improving their shelf-life outside the cold chain, MACIVIVA will explore new galenic vaccine formulations through careful screening of excipients, stabilization and drying methods for generating new vaccine solid forms that can be easily self-administered. Robust “universal” manufacturing processes for upscale production of virosome dried powder for the non-invasive intranasal, oral and sublingual routes should be achieved by month 42.
Paradoxes and metaphors of time in early universe(s)

PROTEUS studies main strategies devised by Western philosophy in representing time in cosmology. It aims at modifying current metaphysics and its relationship with cosmology in the light of recent scientific debates in quantum gravity and quantum cosmology, thereby boosting a new research field in history and philosophy of cosmology. The project is based on two hypotheses: 1) the history of philosophy reveals a guideline that can be traced back to Plato and that characterizes physical and metaphysical approaches to the question of the beginning of the universe in terms of a tension between fundamentality and non-fundamentality of time; 2) there is a conceptual problematic assumption in Western culture and it consists in shaping the problem of the origin of the world as a problem of thinking about the very same conditions of possibility of the origin of a process that is not in time. The project spells out the conceptual roots of current representations of time in quantum gravity and quantum cosmology and highlights the conceptual break that they provide with respect to philosophical concepts of time portrayed in previous systems. PROTEUS explores in detail the notions of time and the paradoxes emerging in the philosophy and cosmology of Plato and Kant and identifies the fundamental characters of emergent time in current quantum gravity theories. In identifying these fundamental features, PROTEUS produces conceptual innovation in metaphysics in such a way that philosophical investigation is complementary to the development of current theories. PROTEUS elaborates alternative argument(s) to anthropic principle, as well as new categories accounting for the notion of ‘contingent necessity’ of the world. The research team includes members from different backgrounds (philosophy, mathematics and physics) and will promote the application of a new methodology emphasizing the relevance of the history of philosophy and the actual interaction between philosophers and scientists.
A Reconfigurable Modeling Approach for Digital Twin-based Manufacturing System

Abstract The emergence of digital twin enables real-time interaction and integration between the physical world and the information world. Digital twin-based manufacturing systems, as a typical representative of smart manufacturing, have a set of advantages beyond the traditional ones, such as verifying and predicting the manufacturing system performance based on the operation of a virtual one. This paper presents a five-dimensional digital twin modeling approach for manufacturing systems, which can not only realize the mapping between the physical and virtual twins, but also some of the capabilities and dependencies of the digital twins can be derived. A reconfigurable strategy, based on the expandable model structure and the reserved interfaces of objective functions and optimization algorithms, is proposed to make the digital twin-based manufacturing system satisfy the various reconfigurable requirements of different granularities and targets. Finally, a prototype system is developed to demonstrate the performance of the reconfigurable digital twin-based manufacturing system, which can improve the operation efficiency of such systems for carrying out the reconfiguring production tasks.
Good Governance in Energy Efficiency

Energy efficiency is at the heart of the Union's efforts to tackle the problems of energy security and climate change. With the recent financial crisis and downturn in the European economy, the case for energy and resource efficiency has become even stronger. Increasing oil and gas prices make it essential to reduce Europe's dependence on primary energy sources and find alternative energy supplies as well as to exploit the existing ones as fully as possible. At the policy making level it is important to design and implement strategies and investments in energy efficiency (EE) with the intention of lowering the amount of unexploited energy and ultimately raising the standard of living and saving money. 

It is crucial therefore to find the most effective ways and methods ensuring less energy consumption. GovernEE intends to address this problem by capitalizing on past and current initiatives in the field of energy efficiency (EE) and the use of renewable energy sources (RES). Specifically the project will focus on the heating public buildings in general and historic buildings in particular, since the public and the communal sector are a major energy consumer and the bulk of energy loss derives from the inefficient heating systems of public buildings.

The project does not focus directly on technological innovations or mere development of networks and exchange of experience. It approaches the problem from the point of view of good governance. By laying emphasis on improving decision-making and planning competences as well as strengthening policy-makers' responsibility (the key elements of good governance), sustainable development in the energy field through responsible energy-conscious policy-making can be achieved.
First presentation of Ebstein’s anomaly in an 80-year-old female patient and unusual occurrence of psychiatric illness in her male offsprings

An 80-year-old female Ebstein’s anomaly patient presented with palpitation and dyspnea of New York Heart Association class III. This is probably the eldest surviving Ebstein’s anomaly patient presenting for the first time with cardiac symptoms at the age of 80 years. She had four sons and two daughters, among whom the first three sons developed psychiatric disorders after 38 years of age, with one son committing suicide because of major depressive episode. This case is unique because of the late age of initial presentation with cardiac problem and the occurrence of psychiatric illness in the male offsprings of the patient. Journal of Advances in Internal Medicine 2013;02(01):21-23 DOI: http://dx.doi.org/10.3126/jaim.v2i1.7634
DEVICES, A COMPUTER PROGRAM PRODUCT AND A METHOD FOR DATA EXTRACTION

A monitoring device is arranged to receive (401) at least one measurement signal obtained by at least one pressure sensor in an extracorporeal fluid system. The extracorporeal fluid system is in contact with a vascular system of a subject via a fluid connection. The monitoring device is configured to process (403) the measurement signal to identify pressure data that represents pulses originating from a first physiological phenomenon in the subject, excluding the heart of the subject. The extracorporeal fluid system may include an extracorporeal blood flow circuit, e.g. as part of a dialysis machine. The first physiological phenomenon may be any one of reflexes, voluntary muscle contractions, non- voluntary muscle contractions, a breathing system of the subject, an autonomous system of the subject for blood pressure regulation, or an autonomous system of the subject for body temperature regulation. The monitoring device may detect, present, track or predict (409) a disordered condition of the subject using the pressure data, or monitor (410) the integrity of the fluid connection based on the pressure data.
Beyond Cultural Wholes?

It is probably no exaggeration to say that no concept has been more centrally discussed in twentieth-century anthropology than the concept of culture (Kroeber and
Kluckhohn 1963 [1952]; Barnard and Spencer 1996: 136; Brumann 1999). Its continued popularity as well as contestation are predominantly linked to the uniquely
influential American tradition of anthropology, with its German antecedents, while the concept has not had the same central place in British and French anthropology (Kuper 1999; Parkin 2005). In a simplified way, one could say that the French tradition has been more interested in the notion of symbolic structure (see Chapter 10, this volume) and the British tradition has largely opted for a focus on society or social structure (see Chapter 14). The concept of culture is undoubtedly one of the key holistic notions of anthropology, although we will see that the nature of the wholes to which it supposedly refers has varied greatly between authors and theoretical traditions.
The particular anthropological usage of culture, which employs the concept in the plural to refer to the different life worlds characteristic of different peoples instead of in the singular to indicate a state of being more or less cultured or civilized, derives from the German Romantic nationalism of the late eighteenth century. Especially influential were the works of the philosopher Johann Gottfried von Herder (1744-1803), who emphasized the principle of equality of all peoples and their cultures, equally deserving of respect for their individual spirit and
design (see Chapter 7). The perhaps earliest and most cited anthropological definition of culture with a holistic connotation to it, E. B. Tylor's notion of culture as a complex whole, does not follow this German tradition. Rather, it is derived from the English and Continental notion of civilization. Culture, considered
synonymous with civilization in his definition,1 is here used in the singular, as something that the whole of humanity has a part in but at different levels or stages
of development. The plural notion of culture, as characteristic of different peoples or nations, entered American anthropology via another route, namely, via the
German migrant Franz Boas, who, originally trained as a physicist and geographer in his country of birth, became the founding father of cultural anthropology in the US (Stocking 1968).
THE EFFECTS OF PARITY NUMBER, SEASON AND YEAR OF CALVING OF SUDANESE ZEBU CATTLE (BUTANA) ON THE LACTATION CURVE AND MILK YIELD

The present study was conducted to investigate the effects of parity number, season and year of calving of Sudanese Zebu cattle (Butana) on the lactation curve and milk yield. A Wood's model (1967) was adopted for the description of the curve, it is a gamma function utilized for regression of milk yield on time lapse post-partum. The regression equation is presented by (Y(n) = an b e -cn ); where: Y(n) is the total milk yield for n th week, a, is the initial milk yield and is considered as a factor which could influence the height of the curve across time but has no effect on the curve. b is the rate of increase of milk yield pre-peak and is considered as the linear constant that measures the average slope of the curve during the increase phase. c is the rate of decrease of milk post-peak, a linear constant that describes the rate of change of the slope of the curve during the decline phase and determines the slope of the curve during this phase. Records of 178 cows were taken from the fifth days of lactation till 30 weeks from the year 1994 - 2001. The records were grouped according to parity (till eight parities), season of calving (dry and wet summer and winter) and year of calving. The results revealed that effect of parity on initial milk yield, although significant, but variable. The peak week, persistency and rate of increase of milk pre-peak were the highest (P<0.01) in parity 1 compared to other parities. However, rate of decrease post-peak was not affected by parity number. Peak yield and total yield increased steadily from parity one to parity 6 then decreased. Calving weight increased significantly (P<0.01) from 1 to 8. Season of calving was shown to have a significant effect on initial milk yield, a, peak week and persistency where, a, was the highest (P<0.01) in wet summer than winter and dry summer and hence was increased to the maximum peak during wet summer with shorter persistency around the peak compared to dry summer and winter. Year of calving significantly affected the rate of decrease post-peak, c, peak yield, weekly and total milk yields. It was shown that cows that calved in year 1997 and 2000 had the lowest (P<0.01) rate of decrease in milk yield, weekly and total yields.
METODOS PARA PROMOVER LA VASCULARIZACION COLATERAL SIN FUGAS

Moléculas de ácidos nucleicos recombinantes codificantes de proteínas transactivadoras quiméricas y su uso para promover la vascularizacion colateral sin fugas. Métodos de tratamiento de trastornos caracterizados por un aumento de la permeabilidad vascular. Reivindicacion 1: Un método de tratamiento de la diabetes en un sujeto consistente en administrar al sujeto una cantidad efectiva de una molécula de ácido nucleico codificante de una proteína transactivadora quimérica biologicamente activa que contiene: (a) el dominio de union a ADN de una proteína de factor inducible por hipoxia y (b) un dominio proteico capaz de activacion transcripcional.
Chinese Brands' Marketing in 2010 FIFA World Cup South Africa——An Example of Yingli China

Chinese brand' entering to the World Cup's marketing ranks,is the pride of Chinese people.With Yingli China entering to the World Cup,there were mainly four factors:technological and economic strength to upgrade,successful marketing of Confucius Institute,scarce resources——the World Cup to attract Chinese enterprises,the world's advocacy about philosophy of environmental protection.The strategies of Chinese brands in the World Cup's marketing were;the strategy of brand personality,the strategy of brand communication,the strategyof brand sales and the strategy of brand management.Yingli China successful entry into the World Cup marketing,to Chinese companies,there were the following revelations;To promote international brand,it should be spent no expense,make full use of characteristics of marketing,take advantage of the integrated marketing opportunities of the medias,promote the green marketing idea.
Increase the competitiveness of BSI as a result of the launch of a new service in the SaaS model.

The aim of the project is to increase the competitiveness of Bussines SOLUTION INTERNATIONAL – ŁUKASZ Kornacki as a result of the launch of a new service in the SaaS model: IT tools supporting the work of insurance agents and brokers. The result of the implementation of the project will include, among others, an increase in the value of the enterprise, an increase in sales revenues and an increase in brand recognition. The investment will be carried out in the period from 1 April 2016 to 31 December 2018. The project provides for the following expenditure: 1) Module CRM 2) Sale module 3) e-campania module 4) Classification module and scenarios 5) Integration module 6) Document archive module 7) Service module in SaaS 8) Dashboard module The above-mentioned expenses are necessary to achieve the project objectives.