SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Dis-Inhibitory circuits in the human cerebral cortex

Temporal co-ordination of the activity of cortical neurons underlies cognitive processes. Intracortical inhibitory circuits set temporal windows for modulation of glutamatergic pyramidal cell firing. In non-human mammals, the activity of the GABAergic neurons is governed by other specialised GABAergic neurons, which can dis-inhibit pyramidal cells. The overarching aim of this project is to define cellular and pharmacological mechanisms of dis-inhibitory circuits in the human cerebral cortex. These circuits could act as regulators of cognitive process. First, we will investigate the neuron types and their synaptic influences to characterise how dis-inhibition controls synaptic integration and the output of neurons. Second, we will elucidate synaptic plasticity in dis-inhibitory circuits, as plastic events likely represent physiological substrates of cognitive operations. Third, we will identify the subcellular sites and the mechanisms of action of key receptors for ACh, monoamines, endocannabinoids, neuropeptides and mGluRs modulating dis-inhibitory circuits, which are targets of small molecule CNS drugs, such as cognitive enhancers. We will test three hypotheses: 1) the human cortical pyramidal cell output is gated by compartment-specific dis-inhibition mediated by specific interneurons; 2) activity-dependent plasticity occurs in dis-inhibitory circuits and has consequences for the output of cortical pyramidal neurons; 3) small molecule drugs act via dis-inhibitory mechanisms at cell-type specific sites altering the inhibitory dynamics of pyramidal cells leading to subcellular redistribution of inhibition and alteration in their output. Combined electrophysiology/imaging with neuropharmacology and high resolution molecular receptor localisation will generate an unprecedented knowledge of the human cortical circuits. Understanding human cortical neuronal connections and their responses to pharmacological interventions may also lead to novel therapeutic strategies.
Cutaneous adverse drug reactions in a hospital-based Chinese population

Cutaneous adverse drug reactions (CADRs) are common skin adverse reactions associated with drugs.To assess recent trends in CADRs and the drugs associated with them, using data from the past 5 years in the largest single database available on a hospital-based population in China.All clinical records of inpatients admitted with a diagnosis of CADR to the Dermatology Ward, Huashan Hospital from January 2004 to December 2008 were retrospectively studied.In the 734 patients, the three most common types of CADRs were nonsevere reactions, erythema multiforme (EM)-like eruptions (n = 255), urticaria (n = 192) and exanthematous reactions (n = 159), followed by three severe reactions: Stevens-Johnson syndrome (n = 58), toxic epidermal necrolysis (n = 29) and exfoliative dermatitis (n = 22). The most common single drug associated with the development of all drug eruptions was allopurinol, followed by amoxicillin, cephalosporins, antiepileptic agents and antipyretic/analgesic agents. However, the most common single drugs associated with severe reactions were antiepileptic agents, followed by allopurinol, antipyretic/analgesic agents and cephalosporins. In contrast to patients with nonsevere reactions, patients with severe reactions were more likely to be male (P < 0.001) and to have a greater mean age of onset (P < 0.001), a longer latency period (P < 0.001) and a longer duration of hospitalization (P < 0.001).In contrast to previous studies, we found allopurinol to be the most common single drug associated with CADRs followed by antibiotics (amoxicillin and cephalosporins), and antiepileptic, especially carbamazepine. A higher incidence of EM-like eruptions and urticaria was also seen.
SUICÍDIO NA POPULAÇÃO IDOSA NO RIO GRANDE DO SUL ENTRE 2015 E 2019

INTRODUÇÃO: Compreende-se suicídio como um ato voluntário contra a vida. É um fenômeno psicossocial que atinge diferentes classes sociais, idades e raças. Segundo a Organização Mundial da Saúde, em quase todas as regiões do mundo, as taxas de suicídio são mais elevadas entre as pessoas com 70 anos ou mais. OBJETIVO: O presente estudo tem como objetivo descrever o número de suicídio na população idosa no Rio Grande do Sul, entre os anos de 2015 e 2019. MÉTODO: Trata-se de um estudo de delineamento quantitativo. Os dados foram extraídos do Sistema de Indicadores de Saúde e Acompanhamento de Políticas do Idoso – SISAP/FIOCRUZ. RESULTADOS: No período supracitado foram registrados um total de 1.811 óbitos por suicídio. No ano de 2015 foram 310 casos e em 2019 foram 406, perfazendo um aumento de 31%. Em relação às cidades com maiores números de casos, destaca-se Venâncio Aires que apresentou um crescimento superior a 150% entre os anos citados. Na classificação por sexo, os homens apresentaram maior número de casos, um total de 1477, as mulheres tiveram uma elevação de 30% entre o período. CONCLUSÃO: O suicídio é um fenômeno complexo, desencadeado por diversas situações de risco como: discriminação, o sentimento de solidão, abuso, violência, relações conflitivas, perdas financeiras, dores crônicas, consumo nocivo de álcool, transtornos mentais e tentativas prévias. É um sério problema de saúde pública mundial, visto pela sociedade como um tabu, compreendido como uma grande ferida emocional que poucos aceitam falar.
AXL-SPECIFIC ANTIBODIES FOR CANCER TREATMENT

The disclosure relates to anti-AXL antibodies, immunoconjugates, and compositions for treatment of cancer, which is resistant to or is predicted to be or become resistant to treatment with a programmed cell death-1/programmed cell death-1 ligand (PD-1/PD-L1) inhibitor.
INTERACTIVE MUSIC PLAYBACK SYSTEM UTILIZING GESTURES

An interactive music system (10) in accordance with various aspects of the invention lets a user control the playback of recorded music according to gestures entered via an input device (14), such as a mouse. The system includes modules which interpret input gestures made on a computer input device and adjust the playback of audio data in accordance with input gesture data. Various methods for encoding sound information in an audio data produce with meta-data indicating how it can be varied during playback are also disclosed. More specifically, a gesture input system receives user input from a device, such as a mouse, and interprets this data as one of a number of predefined gestures which are assigned an emotional or interpretive meaning according to a "character" hierarchy or library (16) of gesture descriptions. The received gesture inputs are used to alter the character of music which is being played in accordance with the meaning of the gesture. For example, an excited gesture can effect the playback in one way, while a quiet playback may affect it in another. The specific result is a combination of the gesture made by the user, its interpretation by the computer, and a determination of how the interpreted gesture should effect the playback. Entry of a excited gesture thus may brighten the playback, e.g., by changing increasing the tempo, changing from a minor to major key, varying the instruments used or the style in which they are played, etc. In addition, the effects can be cumulative, allowing a user to progressively alter the playback. To further enhance the interactive nature of the system, users can be given the ability to alter the effect of a given gesture or assign a gesture to specific places in the character hierarchy.
The places of production and technological enhancement in the framework of thematic tourism

The building heritage of a territory - that is, everything that has been built in the course of centuries or millenniums - is the result of three interacting elements: man, environment and culture. Man is considered as a thread in a tissue of relations, in a long history which has seen moments of cooperation and confrontation, of fruitful peace and hard conflict. Climate has played a major role in determining how roofs were conceived of and planned, or how the proportion between solid and void was thought of (with the use of loggias, porches, arches, etcetera). Culture is to be considered not only as the expression of contemporary art forms, but rather as an expression of the manifold activities of man (both material and intellectual); therefore it also includes the various ways houses were conceived of and devised - and in the Upper Adriatic the house has always represented a value both for individuals and the community. The project thus envisages the cataloguing of the historical buildings having a productive function, which can be found on the territory at issue: mills, tobacco dryers, brick furnaces, cellars, saltworks, oil mills, port structures and warehouses, blacksmiths’ workshops, hydraulic structures (for example in the Theresian reclamation area), farms with important lodges. A digital database collects a detailed graphic and/or photographic documentation about the building heritage considered. The results will be divulged through the publication of a catalogue formed by cards, a documentary travelling exhibition and a series of symposiums.
METHOD AND APPARATUS FOR IMPARTING FAULT TOLERANCE IN A DIRECTOR SWITCH

A method and apparatus for imparting fault tolerance in a switch or the like, particularly in a fibre channel director switch employed in connection with storage area network.
PROCESS FOR FORMING SHAPED ARTICLES COMPRISING CARBON NANOTUBES

A process for manufacturing shaped articles comprising carbon nanotubes comprising the steps of supplying carbon nanotubes in an acidic liquid comprising at least one acid, the at least one acid having a Hammett acidity function less than that of 100% sulfuric acid, the at least one acid having a Hammett acidity function equal or more than that of 90% sulfuric acid, and shaping the acidic liquid comprising carbon nanotubes into a shaped article.
ABSORBENT BODY MANUFACTURING METHOD

FIELD: manufacturing technology.SUBSTANCE: method for preparing an absorbent element according to the invention is a method for manufacturing absorbent element (100) comprising synthetic fibers (10b). Method comprises: a conveying step, comprising conveying a plurality of sheet material pieces (10bh) including synthetic fibers (10b), to recess (41) for accumulation by using box 3; accumulation step consisting in accumulation—in recess (41) for accumulation—of multiple pieces (10bh) of sheet material, displaced at transportation stage, and formation of cluster (100a'), which is component of absorbent element (100), and compression step, which consists in compression of accumulation (100a') on its entire length in direction of thickness.EFFECT: disclosed is a method for manufacturing an absorbent body.20 cl, 9 dwg
Quantum unique ergodicity and random waves on graphs

The proposal aims to address two important conjectures of Quantum Chaos,  Quantum Unique Ergodicity and the Random Wave hypothesis, via the analysis of eigenfunctions of the Laplacian on discrete graphs. It will provide a better understanding of two difficult problems of mathematical physics through an original approach, while developing spectral theory on graphs. The latter has a strong potential of applications in the study of networks, whose understanding is of great importance in the modern world. The expertise of the experienced researcher on analysis on graphs will be ideally complemented by the quantum chaos and ergodic theory specialists of the University of Bristol, to ensure the success of this project.
Energy losses in nitride light-emitting diodes

Light-emitting diodes (LEDs) are the future of lighting for general-purpose and industrial applications because of their potentially superior efficiencies. Group-III nitrides are the principal materials used to manufacture blue and green LEDs. However, they are still rather inefficient, despite a lot of research efforts. Increasing the efficiency and reducing the cost of LEDs is currently the question of paramount importance.

Nonradiative recombination at lattice defects is one of the main causes of reduced efficiencies. Direct experiments to determine the cause of nonradiative recombination are nearly impossible. This clearly calls for accurate theoretical modelling of nonradiative recombination in group-III nitride devices. A first-principles model will not only yield new knowledge about energy losses in nitride LEDs, but will also provide new insights into ways to improve device efficiencies. This is the main goal of the current Marie Skłodowska-Curie project.

The researcher, dr. Audrius Alkauskas, will be returning to Europe after 3.5 years in the USA. He will be employed in the Centre for Physical Sciences and Technology (FTMC), under the supervision of prof. Gintaras Valušis. During the project the researcher will become an independent group leader, and grow as a specialist in semiconductor physics via a close collaboration with his colleagues in Lithuania and abroad.
Sleep, alertness and alertness management among commercial airline pilots on short-haul and long-haul flights

Airline pilots' sleep and on-duty alertness are important focus areas in commercial aviation. Until now, studies pertaining to this topic have mainly focused on specific characteristics of flights and thus a comprehensive picture of the matter is not well established. In addition, research knowledge of what airline pilots actually do to maintain their alertness while being on duty is scarce. To address these gaps in research knowledge, we conducted a field study on a representative sample of the airline pilots of a medium-sized airline. The sample consisted of 90 pilots, of whom 30 flew long-haul (LH) routes, 30 short-haul (SH) routes, and 30 flew both. A total of 86 pilots completed the measurements that lasted for almost two months per pilot. The measurements resulted in a total of 965 flight duty periods (FDPs) including SH flights and 627 FDPs including LH flights. During the measurement periods, sleep was measured by a diary and actigraphs, on-duty alertness by the Karolinska Sleepiness Scale (KSS) in all flight phases, and on-duty alertness management strategies by the diary. Results showed that SH and LH FDPs covering the whole domicile night (00:00-06:00 at home base) were most consistently associated with reduced sleep-wake ratio and subjective alertness. Approximately every 3rd FDP falling into this category involved a reduced sleep-wake ratio (1:3 or lower) and every 2nd a reduced level of subjective alertness (KSS rating 8-9 in at least one flight phase). The corresponding frequencies for the SH and LH FDPs that partly covered the domicile night were every 10th and every 5th FDP and for the pure non-night FDPs every 30th and every 36th FDP, respectively. The results also showed that the pilots tended to increase the use of effective on-duty alertness management strategies (consuming alertness-promoting products and taking strategic naps) in connection with the FDPs that overlapped the domicile night. Finally, the results showed that the frequency of flights involving reduced subjective alertness depended on how alertness was assessed. If it was assessed solely in the flight phase just before starting the landing procedures (top of descent) the phenomenon was less frequent than if the preceding cruise phase was also taken into account. Our results suggest that FDPs covering the whole domicile night should be prioritised over the other FDPs in fatigue management, regardless of whether an FDP is a short-haul or a long-haul. In addition, the identification of fatigue in flight operations requires one to assess pilots' alertness across all flight phases, not only at ToD. Due to limitations in our data, these conclusions can, however, be generalise to only LH FDPs during which pilots can be expected to be well acclimatised to the local time at their home base and SH night FDPs that include at least 3h of flying in the cruise phase.
Transforming research & innovation agendas and support in 4eu+

TRAIN4EU+ is rooted in the 4EU+ alliance’s ambition to strive for excellence in all aspects of our roles as comprehensive, public research-based and excellence focused European universities. Specifically, this proposal will be a transforming effort in our ongoing work to improve and expand how we i) support our researchers as they continue to expand the limits of knowledge and ii) ensure that this knowledge helps society address the challenges of our times.

We will do this by pursuing five objectives. These are: i) We will find new ways to improve - individually and collectively – our support structures for enhancing quality and impact of R&I; ii) We will foster a culture of co-learning and co-innovation across the consortium based on a thorough best-practice assessment; iii) We will pilot selected transformative measures within different modules within the project life time; iv) We will push boundaries by pinpointing and highlighting drivers and facilitators of, as well as barriers and obstacles, to transformative change, v) We will strive to scale up impact, in collaboration with other alliances, and through dissemination and communication to all stakeholders, including targeted events for policy makers, to ensure wide uptake and exploitation of results.

To pursue these objectives, we rely on a systematic methodology to uncover best practises and lessons learned across R&I support functions, to stakeholder involvement, and to share and co-develop innovations and ideas for transformative action across all six universities in 4EU+. We implement this methodology in a concerted effort s across our six core work packages that each relate to the relevant transformation modules. An ambitious dissemination and outreach effort will ensure our learnings are made available for policy makers, fellow universities, civil society, business and other stakeholders; thus providing invaluable input to the ongoing effort of preparing the European universities for the future.
Influence of magnet and flux barrier arrangement for IPMSM with concentrated winding

Interior permanent magnet synchronous motors (IPMSMs) are widely used as highly efficient, high-performance motors. In an IPMSM, the magnet is mainly constructed of rare-earth materials. Recently, however, there has been a trend away from using rare-earth materials due to the high cost and the unpredictability involved in procuring such materials. Therefore, development is required of a lower-cost motor that has equivalent performance, even if it has weaker magnetism. Another recent trend is the adoption of a concentrated winding to reduce copper loss and achieve a smaller size. A motor with a concentrated winding, however, has less total torque due to decrease reluctance torque. In an attempt to improve this situation, in this paper the flux barrier angle in the rotor and the arrangement of the magnets are changed to maximize total torque and to increase the ratio of reluctance torque as much as possible. A model of this type of asymmetrical structure with a slanted magnet demonstrates that total torque and the ratio of reluctance torque are greater than the other structures dealt with in this paper.
Can flow bursts penetrate into the inner magnetosphere?

[1] Recent studies have shown that only a small fraction of fast-flow bursts observed at mid-tail penetrate into the inner magnetosphere, raising questions regarding their role in particle injections. Motivated by these findings, we compared observations at two radially-aligned Time History of Events and Macroscale Interactions during Substorms (THEMIS) spacecraft in the high-beta nightside plasma sheet to determine which physical parameter controls the penetration efficiency of flow bursts observed at the outer spacecraft. We showed that the inferred plasma tube entropy PV5/3 demonstrates better prediction efficiency than other parameters (e.g., Vx or Bz). Comparing its minimal value at the outer spacecraft during the flow burst to its preflow value at the inner spacecraft allows us to distinguish between penetrating and non-penetrating events. Our results explain the relatively small number of deeply penetrating BBFs and provide a strong argument in favor of the bubble model of fast-flow bursts and plasma injections.
State Level Expenditure Management Policy in India: An Empirical Analysis of Odisha State Finance

This study makes an empirical analysis on state finance in India with a special reference to the State of Odisha. Thekey deficit indicators of state have declined significantly, since 2002–03. Bringing down the revenue expenditure without adversely affecting capital expenditure, implementation of fiscal rules in the state and effective liquidity management policy are the key for sound state financial position since 2002–03. The long run elasticity of capital outlay on growth of the gross state domestic product is estimated by employing Vector Error Correction Mechanism in order to provide a policy direction for further reforms in the state finance. This study suggests more capital outlay and capital expenditure through Public Private Partnership (PPP) to further induce growth which will help in more revenue mobilization.
Improvements in concrete roads

421,293. Expansion joints for roads and floors. LANGLEY, F. A., 161, Borough High Street, London. July 31, 1933, No. 21622. [Classes 20 (iv) and 87 (i)] The edges of the sections 1 of a concrete road or floor are reinforced at the expansion joints by embedding, or otherwise securing into the concrete, on either side of the joint, strips 3 of highly compressed concrete. In the construction shown, the strips are faced with a top layer 4 of steel, and the lower faces 5 thereof are grooved to key the strips to the sections 1. In modifications, the keying effect is obtained by forming grooves in one or both side faces of the strips, these grooves being provided instead of, or in addition to, those in the lower faces 5. In another modification the strips are composed of a material known by the Registered Trade Mark " Stelcon," such material consisting of highly compressed concrete faced with a layer of mixed highly compressed concrete and steel chips.
Spatial data discretization methods for geocomputation

Abstract Geocomputation provides solutions to complex geographic problems. Continuous and discrete spatial data are involved in the geocomputational process; however, geocomputational methods for discrete spatial data cannot be directly applied to continuous or mixed spatial data. Therefore, discretization methods for continuous or mixed spatial data are involved in the process. Since spatial data has spatial features, such as association, heterogeneity and spatial structure, these features cannot be handled by traditional discretization methods. Therefore, this work develops feature-based spatial data discretization methods that achieve optimal discretization results for spatial data using spatial information implicit in those features. Two discretization methods considering the features of spatial data are presented. One is an unsupervised method considering autocorrelation of spatial data and the other is a supervised method considering spatial heterogeneity. Discretization processes of the two methods are exemplified using neural tube defects (NTD) for Heshun County in Shanxi Province, China. Effectiveness is also assessed.
Innovation denmark

The Danish EEN will provide skilled Innovation Management Capacity Building personnel to provide two services: 
Key Account Management Services to SMEs in the SME Instrument and Innovation Management Capacity Building services to potential high growth SMEs. A total of minimum 20 service packages will be implemented. 

Two tools will be used to carry out these tasks - Growthmapper for the KAM role, to provide a brief and simple feedback on the company's management ability and IMP3rove for all IMCB cases, to provide a thorough picture of the innovation management capacity of the SMEs. 

Companies in the IMBC work will be integrated with the wider Danish and European innovation support eco-system.