SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Advancing and strengthening Social Enterprises to maximize their impact in the economic and social sector of Central European countries

“Continue to be the motor that lifts and develops the weakest part of your local community and of civil society, especially by establishing companies to provide jobs; be leaders in creating new welfare solutions, as you are already doing…Participate actively in globalization in order to integrate – in the world – development, justice and peace.”- said Pope Francis in 2015 when addressing the Confederation of Italian Cooperatives. _x000D_
_x000D_
Why is the issue of social economy and social enterprises (SEs) so high on the agenda in Europe today, that not only EU leaders but even the Pope encourages their growth and development? Because these undertakings (every 4th in the EU) have the ability to foster inclusive growth, address societal needs and build cohesion by bringing forward new approaches to major societal challenges confronting Europe: an ageing population, growing inequality, climate change and unemployment._x000D_
_x000D_
Social economy is crucial for the convergence of disadvantaged regions of Central Europe, where market forces fail to revive the economy. SEs are key actors in social inclusion and work integration in these regions, but they face many common barriers at their birth, operation and growth. The shortage of skilled labour force and negative effects of demographic change (brain drain, shrinking population), the lack of managerial and professional skills and poor cooperation amongst enterprises are the main hindering factors, while support mechanisms tailored to the local needs and specificities of social businesses are also missing. SENTINEL partners from 6 countries now initiate joint actions to develop and validate novel, widely applicable solutions for skill development, SE mentoring and networking facilitation, enabling SEs to better fulfil their major role in social innovation and inclusive growth. As a result, SEs will be enabled to turn innovative social ideas into viable and sustainable business models, making CE’s regions better places to live and work._x000D_
_x000D_
Information added on 2020-05-18, regarding the mitigation of the effects of COVID-19 (the coronavirus pandemic that started in 2019) (English language only): Social enterprises are drivers of social inclusion and work integration and because of this, regions will need them more than ever to cope with the social consequences of the covid crisis. But this situation is putting their own existence at stake. As core topic of the final conference SENTINEL addressed how their developed Handbook and Toolbox can be opportunities or inspire social enterprises to find their ways through the crisis.
Fully semiparametric Bayesian approach for modeling survival data with cure fraction

In this paper, we consider a piecewise exponential model (PEM) with random time grid to develop a full semiparametric Bayesian cure rate model. An elegant mechanism enjoying several attractive features for modeling the randomness of the time grid of the PEM is assumed. To model the prior behavior of the failure rates of the PEM we assume a hierarchical modeling approach that allows us to control the degree of parametricity in the right tail of the survival curve. Properties of the proposed model are discussed in detail. In particular, we investigate the impact of assuming a random time grid for the PEM on the estimation of the cure fraction. We further develop an efficient collapsed Gibbs sampler algorithm for carrying out posterior computation. A Bayesian diagnostic method for assessing goodness of fit and performing model comparisons is briefly discussed. Finally, we illustrate the usefulness of the new methodology with the analysis of a melanoma clinical trial that has been discussed in the literature.
Common Core State Standards, The Mocombeian Strategy, Reading Room Curriculum, and a Mismatch of Linguistic Structure and Social Class Function

The black-white test score gap is an empirical problematic that dates back to the 1940s. On many standardized tests the mean scores of black students on average are typically at least 1 standard deviation below the mean scores of white students. For the most part, the test scores indicate that on average black American students have more limited skills in processing information from articles, books, tables, charts, and graphs compared to their white and Asian counterparts. In response to this achievement gap of black American students’ vis-a-vis whites and Asians, Paul C. Mocombe developed his Mocombeian Strategy and Reading Room Curriculum, which posit a comprehensive mentoring program of educated black professionals and the restructuring of the linguistic structure of black American inner-city students via phonetic and language arts instructions, as the solutions to resolving the gap. The two approaches are based on Mocombe’s hypothesis that the academic underachievement of black American students vis-a-vis their white and Asian counterparts is grounded in what he refers to as “a mismatch of linguistic structure and social class function.” This work explores the theoretical, practical, and pedagogical relationships between Mocombe’s “mismatch of linguistic structure and social class function hypothesis,” The Mocombeian Strategy, and Reading Room Curriculum (published as Mocombe’s Reading Room Series) as it stands in relation to the common core state standards (CCSS). The article concludes that like Mocombe’s Reading Room Series Curriculum, the CCSS, with its emphasis on language arts and literacy education, will aid black or African-American students in closing the academic achievement gap early on in their academic careers. However, later on as they matriculate through school they will further underachieve because of their social class functions or roles as athletes, entertainers, thugs, etc., in the American postindustrial economy. Key words: Ideological domination; Linguistic structure; Mismatch of linguistic structure and social class function; Capitalism; Underclass; Social structure; African Americans
Single cell approaches for the study of oncogenic processes during coeliac disease.

Coeliac disease is a chronic autoimmune-like enteropathy induced by dietary gluten in 0.5-2% Europeans. A rare but specific complication is the onset of invasive enteropathy-associated lymphomas. The host laboratory has demonstrated that in approximately 70% of CD patients, invasive lymphomas are preceded by a clonal low-grade intraepithelial lymphoproliferation, usually called type II refractory CD (RCDII).
I intend to take advantage of my experience in cellular immunology and single-cell analyses: 1- to analyse the peri-tumor microenvironment and search for anti-tumoral T cell response in RCDII; and 2- to analyse the functional intra-clonal heterogeneity among RCDII malignant cells. The results should provide further insight into the mechanisms, which control disease progression and will help us to assess therapeutic strategies. This project will complete and extend the on-going genomic analysis of lymphomas complicating CD. It will notably help to assess if the JAK1/STAT3 pathway is a pertinent therapeutic target and the possible interest of checkpoint inhibitors.
To achieve the aims of the innovative translational project, I will integrate one of the European leader research center in genetic diseases, giving me the opportunity to gain experience in translational immunology and human genetics, as well as to reinforce my expertise in cutting-edge single cell technologies and bioinformatics. Overall this project represents a unique stepping-stone to complete my training in pathophysiology and establish collaborations, which should put me in excellent position to establish as an independent researcher.
Technical note: Acceleration of sparse operations for average-information REML analyses with supernodal methods and sparse-storage refinements1,2

The objective of this study was to remove bottlenecks generally found in a computer program for average-information REML. The refinements included improvements to setting-up mixed-model equations on a hash table with a faster hash function as sparse matrix storage, changing sparse structures in calculation of traces, and replacing a sparse matrix package using traditional methods (FSPAK) with a new package using supernodal methods (YAMS); the latter package quickly processed sparse matrices containing large, dense blocks. Comparisons included 23 models with data sets from broiler, swine, beef, and dairy cattle. Models included single-trait, multiple-trait, maternal, and random regression models with phenotypic data; selected models used genomic information in a single-step approach. Setting-up mixed model equations was completed without abnormal termination in all analyses. Calculations in traces were accelerated with a hash format, especially for models with a genomic relationship matrix, and the maximum speed was 67 times faster. Computations with YAMS were, on average, more than 10 times faster than with FSPAK and had greater advantages for large data and more complicated models including multiple traits, random regressions, and genomic effects. These refinements can be applied to general average-information REML programs.
ABRASION-RESISTANT, HAND-TEARABLE ADHESIVE TAPE

An abrasion resistant hand-tearable adhesive tape comprising a non-symmetrical weave fabric to which at least one adhesive has been applied. In exemplary embodiments, at least one sealant is applied to the fabric prior to application of the adhesive. The tape may be manufactured in rolls that can be unwound by hand and tape torn by hand.
Deterministic construction of girth‐eight (3, L ) QC‐LDPC codes from quadratic function

For any row weight L and any circulant permutation matrix size P > (L − 1)2 + b 0(L − 1) (b 0 = L − 2 + mod(L,2)), a class of (3,L) quasi-cyclic (QC) low-density parity-check (LDPC) codes is explicitly constructed with girth eight, based on the quadratic function f(x) = x 2 + bx and its derivative, where b is either of the two integers {b 0, − b 0 − 2(L − 2)}. Compared with a similar construction from the so-called difference sequence, the proposed construction is not only much more simple in concept, but also completely deterministic in the sense that no computer search or computing is required. Simulation results show that the new codes significantly outperform the girth-eight codes constructed by the earliest-sequence-based method.
Identification of the role of autophagy during fruit ripening and stress resistance in strawberry: autophagy manipulation as a way to improve strawberry fitness

Autophagy, the major catabolic pathway in eukaryotic cells, has a role in the resistance to biotic and abiotic stresses in different plant species. Plenty of studies show that blocking autophagy by knocking out some of its essential genes leads to plants highly susceptible to this stresses (including heat and drought). However, there are much less studies about the effect of autophagy induction on the response of plants to stresses. Present situation of global warming is already having an effect in agriculture due to a rise in temperature and to water shortages. Therefore, generation of crops with higher resistance to heat and drought should be a priority nowadays. In this proposal I will study the role of autophagy in the maturation of one of the most important berry fruit in EU, Strawberry (Fragaria x ananassa). I will determine the importance of this catabolic process in the response to heat/drought stress in this crop. Furthermore, I will use the diploid strawberry model specie Fragaria vesca to generate transgenic plants with increased autophagy by CRISPR/Cas9 and CRISPR/dCas9 genome editing and analyze the potential benefits regarding general development, fruit quality and stress resistance (this previously shown for Arabidopsis, tomato and apple) that this plants can have compare to wild type. This will be the first basic and applied study of autophagy in strawberry. ""FrATGaria"" will combine my experience in the autophagy field with the expertise of the host group in strawberry development and fruit ripening and will benefit from active collaboration with strawberry breeding groups. The development of this project will allow me to broaden my knowledge about plant development in response to stress strengthening not only my scientific skills but also my leadership, project managment and mentoring capabilities.
Alpine Habitat Diversity

The European Network NATURA 2000 demands the long term surveillance of natural habitats. As established in Berchtesgaden National Park, aerial photographs provide replicable and standardized methods for landscape surveillance on a scale of 1:10.000.
Main objective of the project is to develop a transnational spatial database, which supports the analysis of alpine landscape, its structures, diversity and long term changes, particularly for NATURA 2000 habitats.
The project activities comprise the surface covering census of landscape structures for protected areas throughout the alpine space, the delimitation of landscape structures by a common interpretation code and the compilation of census results in a transnational database.  Integration of additional and more differentiated local data on special subjects into the common database will be possible. Analysis of landscape diversity and surveillance of habitat changes will contribute to a coordinate alpine planning and management.
Building on Prior Knowledge: Schema-dependent Encoding Processes Relate to Academic Performance

Abstract The acquisition and retention of conceptual knowledge is more effective in well-structured curricula that provide an optimal conceptual framework for learning new material. However, the neural mechanisms by which preexisting conceptual schemas facilitate learning are not yet well understood despite their fundamental importance. A preexisting schema has been shown to enhance memory by influencing the balance between activity within the medial-temporal lobe and the medial pFC during mnemonic processes such as encoding, consolidation, and retrieval. Specifically, correctly encoding and retrieving information that is related to preexisting schemas appears rather related to medial prefrontal processing, whereas information unrelated or inconsistent with preexisting schemas rather relates to enhanced medial temporal processing and enhanced interaction between these structures. To further investigate interactions between these regions during conceptual encoding in a real-world university setting, we probed human brain activity and connectivity using fMRI during educationally relevant conceptual encoding carefully embedded within two course programs. Early second-year undergraduate biology and education students were scanned while encoding new facts that were either related or unrelated to the preexisting conceptual knowledge they had acquired during their first year of study. Subsequently, they were tested on their knowledge of these facts 24 hr later. Memory scores were better for course-related information, and this enhancement was associated with larger medial-prefrontal, but smaller medial-temporal subsequent memory effects. These activity differences went along with decreased functional interactions between these regions. Furthermore, schema-related medial-prefrontal subsequent memory effects measured during this experiment were found to be predictive of second-year course performance. These results, obtained in a real-world university setting, reveal brain mechanisms underlying acquisition of new knowledge that can be integrated into preexisting conceptual schemas and may indicate how relevant this process is for study success.
Conversion from packed floating point data to packed 8-bit integer data in different architectural registers

A method and instruction for converting a number from a floating point format to an integer format are described. Numbers are stored in the floating point format in a register of a first set of architectural registers in a packed format. At least one of the numbers in the floating point format is converted to at least one 8-bit number in the integer format. The 8-bit number in the integer format is placed in a register of a second set of architectural registers in the packed format.
Rational engineering of synthetic systems for propagation of information via catalytic assembly of copies

Copying of information-bearing polymer templates is vital to life. The central dogma of molecular biology describes how a sequence of nucleotides in DNA is copied into a sequence of nucleotides in a newly-assembled RNA polymer, and then into a sequence of amino acids in a protein. These processes involve sophisticated machinery in extant organisms, but even the ribosome is bound by the same physical principles as simpler systems that must have operated in early life. Despite the fundamental importance of copying, and its potential for the engineering of complex molecular systems, we do not understand these basic principles that enable accurate and reliable copies to be made of polymer templates, and cannot build minimal synthetic copying systems.

I propose to explore minimal models of copying, leveraging recent advances in the thermodynamics of small, fluctuating systems and the thermodynamics of information processing, to identify these principles. I will translate this insight, via detailed molecular simulation and experimental characterisation of novel reaction motifs, into the construction of minimal synthetic copying systems. I will construct these systems from non-biological synthetic DNA.

The project will provide insight into analogous processes in living organisms, and shed light on primitive living systems. It will also lay the groundwork for engineering synthetic systems with key cell-like functionalities, providing a mechanism for the production of complex assemblies that is fundamentally distinct from traditional self-assembly. Theory and simulation will drive the experiments, making rational design of systems possible whilst providing insight into the fundamental thermodynamics of information processing and computation, and the biophysics of novel nucleic acid interactions. Indeed, designing and building concrete molecular systems based on fundamental theory will enhance our understanding of the theories themselves.
WORK MACHINERY

A controller mounted in a work machine limits a velocity at which a work device approaches a design surface to be equal to or lower than a predetermined limiting velocity in such a manner that the work machine is located above the design surface when an operation device is operated. The controller determines whether a work phase of the work device is compaction work on the basis of a posture of a bucket with respect to the design surface in a case in which the operation device instructs the work device to approach the design surface, and sets the limiting velocity when determining that the work phase of the work device is the compaction work to be higher than the limiting velocity when determining that the work phase of the work device is other than the compaction work.
Effect of Attachment Type on Denture Strain in Maxillary Implant Overdentures: Part 2. Palateless Overdentures

The aim of this study was to examine the deformation modality of palateless maxillary implant overdentures using isolated attachments under various implant configurations.A maxillary edentulous model with implants inserted in the anterior, premolar, and molar areas was fabricated, and three types of unsplinted attachments-ball, locator, and magnet-were set on the implants distributed in various configurations. Experimental palateless dentures were fabricated, and two strain gauges were attached at the anterior midline of the labial and palatal sides. A vertical occlusal load of 98 N was applied, and the shear strains of dentures were measured. The measurements of strains were compared with the Kruskal-Wallis test (P = .05).The strains of the labial side were much larger than those of the palatal side except for those using the ball attachment. The strains using the magnet attachment on anterior implants were significantly larger than those using other attachments (P < .05). Those using anterior implants were significantly smaller than those using premolar or molar implants (P < .05).The strains of palateless overdentures were different according to the attachments and implant distribution. However, when using molar implants, there was no significant difference among the three attachments.
Prospective Randomized Contralateral Eye Evaluation of Subjective Quality of Vision After Wavefront-Guided or Wavefront-Optimized Photorefractive Keratectomy

To compare the effect of wavefront-guided (WFG) and wavefront-optimized (WFO) photorefractive keratectomy (PRK) on patient perceived quality of vision.Seventy-one patients (142 eyes) were enrolled in this prospective, randomized, fellow eye controlled study. One eye was randomized to undergo WFG PRK treatment by the AMO Visx CustomVue S4 IR excimer laser system (Abbott Medical Optics, Inc., Santa Clara, CA) and the fellow eye received WFO PRK treatment by the Alcon Allegretto Wave Eye-Q 400 Hz excimer laser system (Alcon Laboratories, Inc., Fort Worth, TX). Patients answered questionnaires on their visual symptoms and quality of vision preoperatively and at 1, 3, 6, and 12 months after surgery.Patients in both groups reported better vision compared to baseline from 3 months onward (mean change in score of 1.56 to 2.51 in the WFO group and 1.54 to 2.28 in the WFG group, P ⩽ .003). Both groups experienced less nighttime glare from 6 months onward (P ⩽ .030). Halos, double vision, and visual clarity were initially worse (P ⩽ .025) but not significantly different after 1 month. Haze and fluctuating vision resolved after 3 months. Visual symptoms were similar between the two groups at all times (P ⩾ .059) except at 6 months, when patients felt their WFG eyes had more excellent vision (P = .029). A composite of all symptoms was also similar between the groups until 12 months when patients had fewer symptoms in their WFO eye (P = .044).One year after surgery, patient self-reported visual symptoms were not significantly different in eyes receiving WFG or WFO PRK. However, the average of all symptoms was lower in eyes receiving wavefront-optimized treatment.
Combination of Tumor Necrosis Factor α and Interleukin-6 Induces Mouse Osteoclast-like Cells With Bone Resorption Activity Both In Vitro and In Vivo

To clarify the function of osteoclast-like multinuclear cells differentiated from bone marrow-derived macrophages (BMMs) by a combination of tumor necrosis factor α (TNFα) and interleukin-6 (IL-6), and to investigate the molecular mechanisms underlying the differentiation.BMMs were stimulated by TNFα and/or IL-6. The cells were then compared with conventional osteoclasts differentiated in vitro by RANKL. An in vitro pit formation assay on dentine slices and an in vivo resorption assay of calvarial bones were performed. We also evaluated the activities and expression levels of NF-κB, c-Fos, and NF-ATc1, which are essential to the differentiation of conventional osteoclasts. Small interfering RNA was used to knock down c-Fos. The effects of genetic ablation of STAT-3 and pharmacologic inhibitors of NF-AT, JAK, and ERK were also studied.Osteoclast-like cell differentiation depended on TNFα and IL-6 and was not inhibited by osteoprotegerin. These differentiated cells were associated with both in vitro and in vivo bone resorption activity. TNFα and IL-6 had a synergistic effect on the activity and expression of c-Fos. Knockdown of c-Fos inhibited the expression of NF-ATc1 and the differentiation of osteoclast-like cells. All of these inhibitors blocked differentiation of the cells in vitro, but surprisingly, the conditional knockout of STAT-3 did not. Tofacitinib also inhibited the bone destruction caused by TNFα and IL-6 in vivo.Our results demonstrate that a combination of the inflammatory cytokines TNFα and IL-6 can induce osteoclast-like cells that have in vitro and in vivo bone-resorptive activity.