SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Decoding context-dependent genetic networks in vivo

The evolutionary success of multicellular organisms is based on the division of labor between cells. While some of the molecular determinants for cell fate specification have been identified, a fundamental understanding of which genetic activities are required in each cell of a developing tissue is still outstanding. The DECODE project will develop and apply leading-edge system genetics methods to Arabidopsis and Drosophila, two major model systems from the plant and animal kingdoms to decode context-dependent genetic networks in vivo. To achieve this, DECODE will bring together experimental and theoretical groups with complementary expertise in model organism genetics and cellular phenotyping, single-cell genomics, statistics and computational biology. Building on our combined expertise, we will create functional genetic maps using conditional CRISPR/Cas9-based single- and higher order knockout perturbations in vivo combined with single-cell expression profiling and imaging. Coupled with powerful computational analysis, this project will not only define, predict and rigorously test the unique genetic repertoire of each cell, but also unravel how genetic networks adapt their topology and function across cell types and external stimuli. With more than thousand conditional knockouts, characterized by several million single-cell transcriptome profiles and high-resolution imaging this project will create the largest single-cell perturbation map in any model organism and will provide fundamental insights into the genetic architecture of complex tissues. Analyzing two tissues with divergent organization and regulatory repertoire will enable us to uncover general principles in the genetic circuits controlling context
dependent cell behavior. Consequently, we expect that the DECODE project in model organisms will lay the conceptual and methodological foundation for perturbation-based functional atlases in other tissues or species.
Development and Optimization of a New Occupant Restraint System for Improving Mini Vehicle Safety

With the increasing number of vehicles, transportation safety has become an important issue globally. Compared to other vehicles, mini vehicles usually don’t meet the requirement of safety regulations due to its compact occupant space. Moreover a mini vehicle is usually designed without an airbag. In this study, a new complete facet occupant restraint system (ORS) model of a mini vehicle without airbag is studied. An improvement for this was considered by comparing the mini vehicle to a multi-body model, was developed using MADYMO and validated against partial test data. Optimization technique was used to determine the optimum parameters of ORS. Results show that seatbelt stiffness is the most significant factor for head injuries in drivers. For a compact mini vehicle with high stiffness and without airbag, high seat belt elongation, low collapse force of collapsible steering column less than 2500 N can effectively reduce the injury of driver in frontal crash.
Dynamic prediction and compensation of aerocraft assembly variation based on state space model

Purpose – This paper aims to clarify the predicting and compensating method of aeroplane assembly. It proposes modeling the process of assembly. The paper aims to solve the precision assembly of aeroplane, which includes predicting the assembly variation and compensating the assembly errors. Design/methodology/approach – The paper opted for an exploratory study using the state space theory and small displacement torsor theory. The assembly variation propagation model is established. The experiment data are obtained by a real small aeroplane assembly process. Findings – The paper provides the predicting and compensating method for aeroplane assembly accuracy. Originality/value – This paper fulfils an identified need to study how the assembly variation propagates in the assembly process.
viciLogic: Online learning and prototyping platform for digital logic and computer architecture

This paper describes and demonstrates the viciLogic platform as an effective pedagogical solution for online technology enhanced learning, assessment and prototyping of digital logic and computer architecture systems. viciLogic provides an opportunity to improve digital systems education globally and to develop the global digital logic design community, with a positive impact on future digital logic technologies. viciLogic provides direct access and interaction with an array of Reconfigurable Computing (RC) digital logic hardware in the Cloud using only an internet connection. Learning and prototyping is facilitated through interactive user control and probing of hardware in the Cloud in real time. vici:Learn provides intuitive, structured learning and assessment of digital logic hardware design. vici:Lab has been developed for easy, automated, scalable and low cost hardware design prototype and interactive GUI development using both Cloud-based RC hardware and local RC hardware.
Language, families, and society

Building on my previous research on Family Language Policy (FLP), LaFS (‘Language, Families, and Society’) will focus on three types of linguistic minority families—autochthonous, immigrant, and refugee—as a means to elucidating more about how social inequality is perpetuated (or arrested) along linguistic lines, and how policy at the local, national, and international levels can better support linguistic minority families. The project will therefore provide a key means to understanding more about Europe’s three main sociolinguistic challenges: the decline of its many autochthonous minority languages; increased linguistic diversity due to increased mobility among European member states; and the refugee crisis. LaFS will centre on families who speak Irish as a home language (autochthonous); Polish (immigrant); and Arabic (refugee) as a means to understanding the challenges these linguistic minority families face and how these challenges affect their sense of identity, belonging, and overall well-being. This understanding will be broadened by a secondment with the Glasgow Refugee, Asylum, and Migration Network (GRAMNet). LaFS will be hosted by the National University of Ireland, Galway, complementing NUIG’s Centre for Population and Migration Research and UNESCO Child and Family Research Centre. The project will be supervised by Prof. Tadhg Ó hIfearnáin, a leading expert in minority language issues. The secondment will be supervised by Professor Alison Phipps, UNESCO Chair in Refugee Integration through Languages and the Arts. My professional development over the course of the project in terms of innovative research practice; high-impact dissemination and communication skills; and effective project management skills will be invaluable to my long-term goal of embedding sociolinguistics into social justice research.
Investigating the Effect of Uncertainty on a LP Model of a Petrochemical Complex: Stability Analysis Approach

This study discusses the effect of uncertainty on production levels of a petrochemical complex. Uncertainly or variations in some model parameters, such as prices, supply and demand of materials, can affect the optimality or the efficiency of any chemical process. For any petrochemical complex with many plants, there are many sources of uncertainty and frequent variations which require more attention. Many optimization approaches are proposed in the literature to incorporate uncertainty within the model in order to obtain a robust solution. In this work, a stability analysis approach is applied to a deterministic LP model of a petrochemical complex consists of ten plants to investigate the effect of such variations on the obtained optimal production levels. The proposed approach can determinate the allowable variation ranges of some parameters, mainly objective or RHS coefficients, before the system lose its optimality. Parameters with relatively narrow range of variations, i.e. stability limits, are classified as sensitive parameters or constraints that need accurate estimate or intensive monitoring. These stability limits offer easy-to-use information to the decision maker and help in understanding the interaction between some model parameters and deciding when the system need to be re-optimize. The study shows that maximum production of ethylene and the prices of intermediate products are the most sensitive factors that affect the stability of the optimum solution. Keywords—Linear programming, Petrochemicals, stability analysis, uncertainty
MULTIPLE PUMP ARRANGEMENT

The invention relates to an adaptive eccentric screw pump (2), which enables, if necessary, an increase of the output, the pressure and/or the simultaneous output of more than one output medium, and wherein the eccentric screw pump (2) has comparably low energy consumption and the production and maintenance expenditure thereof is kept low. For this purpose, according to the invention, the eccentric screw pump (2) is equipped with a modular output system, comprising at least two output modules (4, 6, 38, 40) comprising in each case one rotor (10) and one stator (8), wherein the output modules (4, 6, 38, 40) are coupled to one another and merely one actuation unit (14) is associated with the output system, and wherein the output system for an output medium has more than one inlet and/or outlet (18, 24) or at least one modular perfusion housing (12).
Instantaneous strain rate sensitivity of wrought AZ31 magnesium alloy

Abstract The strain rate sensitivity evolution of a wrought AZ31 magnesium alloy was studied using strain rate jump (SRJ) testing technique. The strain rate jump tests were conducted in a wide temperature range of 200–550 °C under the base strain rates of 0.01 and 0.001 s−1. The material exhibited the negligible strain-rate sensitivity at relatively low temperatures. However, the rate sensitivity of the alloy was found to be increased with increasing deformation temperature due to thermally activated nature of dislocation motion. In addition, the results indicated a rate sensitivity drop above 500 °C. This ascending/descending trend in positive rate sensitivity domain is systematically discussed relying on the main mechanisms operating in the related deformation conditions. Besides the effect of deformation temperature on the strain rate sensitivity, the influences of strain and strain rate are also properly addressed through this manuscript.
Quantum deformation of quantum cosmology: A framework to discuss the cosmological constant problem

We endorse the context that the cosmological constant problem is a quantum cosmology issue. Therefore, in this paper we investigate the $q$-deformed Wheeler-DeWitt equation of a spatially closed homogeneous and isotropic Universe in the presence of a conformally coupled scalar field. Specifically, the quantum deformed Universe is a quantized minisuperspace model constructed from quantum Heisenberg-Weyl $\mathcal U_q(h_4)$ and $\mathcal U_q(su(1, 1))$ groups. These intrinsic mathematical features allow to establish that ($i$) the scale factor, the scalar field and corresponding momenta are quantized and ($ii$) the phase space has a non-equidistance lattice structure. On the other hand, such quantum group structure provides us a new framework to discuss the cosmological constant problem. Subsequently, we show that a ultraviolet cutoff can be obtained at $10^{-3} eV$, i.e., at a scale much larger than the expected Planck scale. In addition, an infrared cutoff, at the size of the observed Universe, emerges from within such quantum deformation of Universe. In other words, the spectrum of the scale factor is upper bounded. Moreover, we show that the emerged cosmological horizon is a quantum sphere $S^2_q$ or, alternatively, a fuzzy sphere $S^2_F$ which explicitly exhibits features of the holographic principle. The corresponding number of fundamental cells equals the dimension of the Hilbert space and hence, the cosmological constant can be presented as a consequence of the quantum deformation of the FLRW minisuperspace.
Degradation triggered by modular design

The project DETRIMODE (DEgradationTRIggered by MOdular Design) aims at the development of a methodology for the modular synthesis of Targeted Protein Degradation Inducers (TPDI), designed as bifunctional molecules apt to the degradation of target proteins via recruitment of the ubiquitin proteasome system, a process with therapeutic prospects if applied to disease driving proteins. TPDIs are comprised of an E3 ligase ligand and a target protein ligand joined by a spacer (linker), to bring the ubiquitinating system and the target protein in close proximity, so to promote degradation of the latter. The formation of the ternary complex (target protein-TPDI-E3 ligase) is an articulated process influenced by a series of factors, such as ligands affinity, linker length and composition and molecular features of the proteins involved. The project tackles this endeavour in stages of increasing innovation, progressively incrementing the scope, flexibility and efficiency of modular synthetic access to arrays of tripartite molecules via protected, solid grafted intermediates, combinable with a variety of target ligands.  New chemical entities TPDIs will be generated targeting selected purinome proteins oncology-related.  
This project will be pursued within the Chemical Core Technologies Dept. of a fully integrated company (NMS), engaged in the discovery and development of new small molecule based drugs. Organic and solid phase chemistry, computational and structural chemistry, molecular and cell biology, among others, will be exploited to achieve the project’s goal. In such multidisciplinary environment, this new technology will grow at the same speed with the researcher’s medchem competence, increasing the chance of mutual success. DETRIMODE outcomes will be shared with peers, while updates on its progresses as well as general information on how EC-funded research have impact on the general public will be communicated by a number of means, bringing science closer to society
Twist as a new prognostic marker in hematological malignancies

Twist proteins are members of basic helix-loop-helix family and are major regulators of embryogenesis. In adult humans, Twist proteins are mainly expressed in precursor cells, including myogenic, osteoblastic, chondroblastic and myelomonocytic lineages, maintaining their undifferentiated state. In addition, they play important roles in lymphocyte function and maturation. Recently, several studies have reported regulatory roles for Twist in the function and development of hematopoietic cells as well as in survival and development of numerous hematological malignancies. It is activated by numerous signal transduction pathways, including Akt, nuclear factor κB, Wnt, signal transducer and activator of transcription 3, mitogen-activated protein kinase and Ras signaling. Activated Twist has an anti-apoptotic role and protects cancer cells from apoptotic cell death. In addition, overexpression of Twist promotes the process of epithelial-mesenchymal transition, which has an essential role in cancer metastasis. Hereby, we review the aberrant expression of Twist in hematopoietic malignancies such as leukemias, lymphomas and myelodysplastic syndrome, which is related with poor prognosis and drug resistance in these disorders. Inactivation of Twist by small RNAs technology or chemotherapeutic inhibitors targeting Twist and upstream or downstream molecules of Twist signaling pathways may be helpful in management of disease to improve treatment strategies in malignancies.
Code generation and adaptive control divergence management for light weight SIMT processors

The energy costs of data movement are limiting the performance scaling of future generations of high performance computing architectures targeted to data intensive applications. The result has been a resurgence in the interest in processing-in-memory (PIM) architectures. This challenge has spawned the development of a scalable, parametric data parallel architecture referred at the Heterogeneous Architecture Research Prototype (HARP) - a single instruction multiple thread (SIMT) architecture for integration into DRAM systems, particularly 3D memory stacks as a distinct processing layer to exploit the enormous internal memory bandwidth. However, this potential can only be realized with an optimizing compilation environment. This thesis addresses this challenge by i) the construction of an open source compiler for HARP, and ii) integrating optimizations for handling control flow divergence for HARP instances. The HARP compiler is built using the LLVM open source compiler infrastructure. Apart from traditional code generation, the HARP compiler backend handles unique challenges associated with the HARP instruction set. Chief among them is code generation for control divergence management techniques. The HARP architecture and compiler supports i) a hardware reconvergence stack and ii) predication to handle divergent branches. The HARP compiler addresses several challenges associated with generating code for these two control divergence management techniques and implements multiple analyses and transformations for code generation. Both of these techniques have unique advantages and disadvantages depending upon whether the conditional branch is likely to be unanimous or not. Two decision frameworks, guided by static analysis and dynamic profile information are implemented to choose between the control divergence management techniques by analyzing the nature of the conditional branches and utilizing this information during compilation.
“Top-Down” Effects Where None Should Be Found

A tidal wave of recent research purports to have discovered that higher-level states such as moods, action capabilities, and categorical knowledge can literally and directly affect how things look. Are these truly effects on perception, or might some instead reflect influences on judgment, memory, or response bias? Here, we exploited an infamous art-historical reasoning error (the so-called “El Greco fallacy”) to demonstrate that multiple alleged top-down effects (including effects of morality on lightness perception and effects of action capabilities on spatial perception) cannot truly be effects on perception. We suggest that this error may also contaminate several other varieties of top-down effects and that this discovery has implications for debates over the continuity (or lack thereof) of perception and cognition.
The interaction of colloidal particles with weak homeotropic anchoring energy in homogeneous nematic liquid crystal cells

We have investigated interactions of colloidal particles with weak homeotropic anchoring energy in homogeneous nematic liquid crystal cells. Particle-wall and inter-particle interactions were observed experimentally and analyzed using typical dipole-dipole and quadrupole-quadrupole interactions, including substrate effects as the image charges. Both experimental results matched well with the calculated results for the effective particle radius reflecting the weak anchoring. The effective radius is reduced by the amount of extrapolation length than the actual particle radius. The effective radii of polyethylene micro-particles were reduced to a coefficient ζ (0.78 ≥ ζ ≥ 0.52) times the actual radius with anchoring coefficients in the range of 3.8 × 10(-6) to 1.4 × 10(-6) J m(-2). The anchoring energy of the particles is, therefore, a key component for explaining liquid crystal colloidal systems.
Generic Model Assist

Model assist is a feature of modelling environments aiding their users with entering well-formed models into an editor. Current implementations of model assist are mostly hard-coded in the editor and duplicate the logic captured in the environment's validation methods used for post hoc checking of models for well-formedness. We propose a fully declarative approach which computes legal model assists from a modelling language's well-formedness rules via constraint solving, covering a large array of assistance scenarios with only minor differences in the assistance specifications. We describe an implementation of our approach and evaluate it on 299 small to medium size open source models. Although more research will be needed to explore the boundaries of our approach, first results presented here suggest that it is feasible.
The International Pulsar Timing Array

The International Pulsar Timing Array (IPTA) is an organisation whose raison d'etre is to facilitate collaboration between the three main existing PTAs (the EPTA in Europe, NANOGrav in North America and the PPTA in Australia) in order to realise the benefits of combined PTA data sets in reaching the goals of PTA projects. Currently, shared data sets for 39 pulsars are available for IPTA-based projects. Operation of the IPTA is administered by a Steering Committee consisting of six members, two from each PTA, plus the immediate past Chair in a non-voting capacity. A Constitution and several Agreements define the framework for the collaboration. Web pages provide information both to members of participating PTAs and to the general public. With support from an NSF PIRE grant, the IPTA facilitates the organisation of annual Student Workshops and Science Meetings. These are very valuable both in training new students and in communicating current results from IPTA-based research.
Evaluation des performances agronomiques de différentes variétés de gombo (Abelmoschus esculentus) dans les conditions agropédoclimatiques de Bambey, Sénégal

Résume: Le gombo est un légume cultivé toute l'année au Sénégal mais surtout en saison chaude.Cependant les rendements de la culture sont parfois faibles dans certaines zones pays, une faiblesse liée à l'inadaptabilité des variétés cultivées.Cette présente étude a été réalisée dans le but de voir quelles sont les variétés les plus performantes dans les conditions irriguées du Bassin arachidier.L'étude a porté sur sept variétés et a été réalisée à partir d'un dispositif en blocs aléatoires complets à trois répétitions.Les résultats montrent que la variété JKOH est la plus précoce, le nombre de jours à 50 % floraison est à 49 jours.Seule la variété ROUGE DE THIES a un pH proche de l'acidité (pH=5.76),elle a été également parmi les moins visqueuses avec la variété BASANTI.Pour les composantes de rendement, les variétés BALTO et JKOH ont obtenu les rendements en fruits les plus élevées avec respectivement 25.68 t/ha et 23.82 t/ha.Les résultats ont aussi montré que la croissance et le développement des différentes variétés étudiées dépendent de leur capacité d'adaptation au milieu mais également de leur Evaluation des…
Business as Usual? An Institutional View of the Relationship Between Management Control Systems and Strategy

The relationship between management control systems (MCS) and strategy has received considerable attention in the management control literature. Contingency-based approaches, however, have traditionally dominated this research, with limited attention devoted specifically to how MCS and strategy may combine in organisations operating within highly institutionalised environments. Adopting an institutional perspective, the current study is based on interviews with CEOs and senior executives in 32 Australian Not-for-Profit organisations. Our findings indicate a tendency for these organisations to decouple informal control from MCS, producing a ‘business as usual’ mentality via the pervasive informal approach to control, supplanting contingency-based predictions relating to MCS-strategy relations.