SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
MACHINE TOOL, IN PARTICULAR GRINDING AND/OR ERODING MACHINE, AND METHOD FOR EXCHANGING A TOOL ASSEMBLY

The invention relates to a machine tool (20), for example a grinding machine and/or an eroding machine (21). The machine tool has a machine base (22) and an axle arrangement (23) for moving a tool carrier (25) and/or a workpiece clamping device (26) relative to the machine base (22). A transport device (75) having preferably exactly two transport spaces (76) for a respective tool assembly (27) is provided on the machine base (22). A robot arm (42) having a gripping device (44) is designed to grip and move either two workpieces (38) or alternatively a single tool assembly (27). As a result, a workpiece change can be carried out directly with the workpiece clamping device (26) via the robot arm (42) or a tool assembly (27) can be accommodated and arranged in the transport device (75) or removed from the transport device (75). The transport device (75) can be moved out of the working area (A) of the machine tool (20) and into the working area (A) and, in cooperation with the axle arrangement (23) of the machine tool (20), can perform an exchange of the tool assembly (27) on the tool carrier (25).
Directed evolution in drops

Natural evolution is a powerful process that has given rise to the functionally diverse set of proteins present in all living systems. Repetitive rounds of mutation, selection and amplification have optimised nature’s catalysts, the enzymes, to perform an enormous range of different reactions. However, natural evolution has driven the optimisation of enzymes subjected to living functions of microorganisms, according to ill-defined and fluctuating external conditions and is not suitable
for industrial processes since it lacks of control of selection pressure. In EVOdrops, we will use directed evolution to overcome these limitations. It is a synthetic, man-made approach of evolution, aiming at improving living systems based on predefined needs, controlling the external selection pressure. While natural evolution took billions of years to optimise
macromolecules, directed evolution – to be efficient in an industrial process – requires both the generation of genetic diversity and ultra-high throughput screening capabilities to recover the variants of interest. We will develop and optimise these tools using the ground-breaking potential of droplet-based microfluidics for high-throughput experimentation and the
fine control of gene library construction. EVOdrops, a European training network, will bring together the leading research scientists, laboratories and industries in Europe with outstanding expertise in protein engineering and microfluidics and 13 early stage researchers. We will offer an extensive multi- and interdisciplinary training to ensure that they can solve these urgent and unmet challenges in biotechnology and biomedicine. We will use a multidisciplinary approach combining soft matter, microfluidics and chemical biology to design solutions for the selection of new enzymes of industrial and therapeutic interest. In the future, our approaches can be generalised to challenges involving high-throughput miniaturised biochemical or cell-based assays.
PHARMACEUTICAL COMPOSITIONS OF TASTE-MASKED LINEZOLID

The present invention relates to a pharmaceutical composition of linezolid for oral administration, comprising taste-masked linezolid and at least one pharmaceutically acceptable excipient. The taste-masked linezolid comprises linezolid and at least one taste-masking agent. The invention further relates to methods for masking the objectionable taste of linezolid by using at least one taste-masking agent and its incorporation into such palatable formulations. The pharmaceutical compositions of taste-masked linezolid are suitable for oral administration as suspensions, powders for suspensions, dispersible tablets, orally disintegrating tablets, chewable tablets, effervescent tablets and the like.
Ingestion and digestion of live microalgae and microalgae concentrates by sandfish, Holothuria scabra, larvae

Abstract Information on the nutritional requirements and preferred diets of sea cucumber (Holothuriidae) larvae is extremely limited and this has hindered development of hatchery culture methods. This study assessed ingestion and digestion of two live (TISO and Chaetoceros muelleri ) and six concentrated microalgae (Instant Algae®, Reed Mariculture Inc.) by sandfish ( Holothuria scabra ) auricularia larvae of different ages using epifluorescence microscopy. This is the first study to report the use of epifluorescence microscopy with larval echinoderms and experiments were conducted using 2, 6 and 10 day old auricularia larvae. Seven of the eight microalgae tested were ingested and digested by the larvae with digestion occurring more rapidly in older larvae. C. muelleri was rapidly digested by 6-day and 10-day old larvae but our results indicate that C. muelleri is unsuitable as a food for 2-day old sandfish larvae. TISO was well ingested by sandfish larvae in both live and concentrated forms and live TISO was the most suitable of the microalgae tested in terms of ingestion and digestibility. All commercially available microalgae concentrates tested were readily ingested and digested by H. scabra larvae with the exception of Thalassiosira pseudonana (3H 1800®) which was not ingested by larvae of any of the three ages tested. Our results show potential for using microalgae concentrates as alternatives to live microalgae in hatchery culture of sandfish. However, further research should be conducted to assess the relative nutritional values of digestible microalgae as a basis for optimising a diet for hatchery culture of sandfish, and to provide further information on the nutritional requirements of sandfish larvae.
SEAT TUBE WITH A CONTINUOUS CURVE CONFIGURATION FOR A BICYCLE

A bicycle frame. The frame comprising a bottom bracket; a top tube, a head tube, a down tube and a seat tube, and first and second seat stays, and first and second chain stays. One end of the top tube and one end of the down tube is affixed to the head tube, and the other end of the top tube being affixed to one end of the seat tube. One end of each of the seat stays is affixed to the seat tube, and the other end of each of the seat stays is affixed to respective ends of the chain stays. The other end of the down tube and the other end of the seat tube and the other end of each of the chain stays form a juncture for connecting or affixing the bottom bracket. According to an embodiment, the seat tube comprises an upper section configured for attachment to the top tube in the bicycle frame; a lower section configured for attachment to the bottom bracket in the bicycle frame; and a curved section, the curved section spanning at least a portion between the upper section and the lower section.
SPECIES OF MRFFT1 CELL

The Invention relates to a MRFFT1 cell and a preparation method thereof. The Invention screens out mutant polypeptides with prediction of antigenic determinants, and links and synthesizes the expression gene sequences of mutant polypeptides. Meanwhile, the MVA virus vector is constructed to package MVA virus, and APC cells are transfected to complete the modification of specific MV cells, and PBMCs isolated from peripheral blood are co-cultured in vitro to screen out the effective polypeptide, and ordinary T cells is transformed into RFF cells with more precise killing through the second pulse of precise effective polypeptide stimulation. Then, the principle of TCR-T technology is used to modify the T cells, and gene coding technology is used to knock out the immunosuppressive target of the modified T cells. The specific killing T cells are precisely protected from in vivo inhibition, and the cytotoxicity of T cells to tumor cells is improved.
EMISSION AND TRENDS IN RECLAIMING WASTE HEAT IN INDUSTRIAL INSTALATIONS

The article presents the analysis of waste heat emission in a typical industrial installation. On the basis of the process monitoring system, periodic analyses of fumes composition, installation process manual and the conducted measurements of the heat fluxes from individual sources emitting heat on the way of natural convection from the devices’ coats and forced convection in the fumes flux were calculated. According to the authors the heat of temperature 140–155 °C and surface power density 860–970 W/m 2 emitted by devices’ covers can be reclaimed in ORC techniques, Peltier’s modules and the systems realising Stirling cycle. Part of the waste heat included in fumes, which makes c.a. 76% of the total emission from the installation, should be returned to the process of fuel oxidation, what will reduce the emission by c.a. 18% and the volume of consumed fuel by c.a. 25 m 3 CH 4 /h, according to the presented calculations.
Climate impacts of the atlantic meridional overturning circulation

CliMOC is a proposal to fund a fellowship to be carried out by the Experienced Researcher (ER) Katinka Bellomo at host institution Polytechnic University of Turin, Italy (POLITO) in the department of Environment, Land and Infrastructure Engineering under the supervision of main host professor Jost von Hardenberg. The aim of the proposed work is to investigate the role of the Atlantic Meridional Overturning Circulation (AMOC) on climate impacts over Europe. Previous studies have shown an important role for the AMOC in modulating global climate change, in particular over the Northern Hemisphere and Europe. An AMOC collapse has been identified as a possible trigger of the initiation of Ice Ages. However, the influence of AMOC in future climate change is still unclear given the large inter-model uncertainty in the decline rate of AMOC, and the concurrent climate changes due to increasing concentrations of well-mixed greenhouse gases in the atmosphere. In this proposal, we advance some hypotheses for the role of AMOC in the current climate and future climate change, and we propose a hierarchy of climate model simulations to separate the role of AMOC from other processes. More specifically, we plan to implement a slab-ocean model component in the EC-Earth global climate model. Using the ocean heat fluxes from a fully-coupled EC-Earth simulation in which the AMOC is artificially weakened, we will be able to run a slab-ocean EC-Earth simulation with a high-resolution atmospheric component, which will let us investigate the role of AMOC in future climate change impacts over Europe. This work will help reduce the uncertainties in projections of future climate change by constraining the influence of AMOC.
Wallco quality modular solid wood furniture

Wallco will develop furniture designed to meet the needs of people by creating modular wooden furniture that is creative, sustainable, versatile, user-friendly, and developed with user-led design paradigms. This concept will provide useful furniture that meets the changing demands of users for years to come and is founded on sustainability concepts including renewable material use, recycling, and material cascading.

Conceptually, Wallco’s modular wood furniture follows the LEGO toy bricks paradigm – widely customisable, reusable, repurposable, easy to work with, and fun. In addition to the versatility of LEGO Bricks, their use prompts creativity and offers endless options with a very successful underlying business model. Like LEGO Bricks, Wallco will provide a business model based on expansion of the owners collection. The versatility of the product will prompt users to come up with their own uses for the product, generating demand for expanding the owner’s collection of components as their needs and preferences change.

The novelty of this project is the combination of both the innovative products and the innovative service that supports our products. The innovative products are quality modular solid wood furniture that are very versatile. The supporting service will include online and physical furniture stores where customers have access to our products and learn about the advantages that Wallco products and support service offer.
Advanced uninterrupted radio

AURA (Advanced Uninterrupted RAdio) is a new concept of in-car radio that aims at replacing the in-dash AM/FM/DAB and Satellite radios worldwide. 
AURA overcomes the limitations of the existing in-car radio technologies (mutual interference, limited number of stations, poor signal coverage in difficult environments, etc.) using a sophisticated  combination of a buffering technology and a multicasting packetized data transfer as described in our Patent application.
AURA delivers high quality listening for a potentially unlimited number of radio stations, while ensuring a location-independent, interference-free and interruption-free experience,  even under conditions of dropouts and outages in the wireless segment of the network, where other technologies cannot operate.
AURA is a highly scalable client-server technology because it uses a hybrid multicast system to optimize the bandwidth of the wireless segment of the network. The client connects to the server via a Digital Wireless Network to receive high quality audio, and may communicate its position in order to receive location-based services such as traffic data and geo-targeted adverts. 
Current AURA prototype utilizes a PC as server and a smartphone as Client device.
AURA development is based on AvMap solid Know How in Software and Hardware design and will be brought to market through AvMap long-term relationship with carmakers and Telco companies: AvMap is Tier1 supplier of satellite navigation and connectivity systems for European and Global carmakers.
The outcome of Phase 1 will be a detailed feasibility study including costs’ assessment and economic viability obtained with the implementation of a larger scale prototype infrastructure involving a multitude of users and stakeholders.
AURA has the potential to become the next must-have equipment for car manufacturers in the European market. Moreover, AURA can generate more opportunities for other SMEs creating a Long Tail of radio contents and advertising.
Exodata: a commercially supported space telescope

ExoData will use results from the very successfull ExoMol Advanced Award which created comprehensive spectroscopic line lists to help understand and model the atmospheres of exoplanets. ExoData will help build and fund a satellite aimed at characterising exoplanet atmospheres using a cheap, agile, low earth orbit satellite mission with a launch date this decade. This mission will be part funded by
the sale of telescope data to interested international clients. This is a new business model for astonomical satellites. ExoData will (a) fund business development in partnership with a small company created
to sell telescope and other data from this mission and (b) use the results of the ExoMol project to model results from this mission and to create software and models that have potential re-sale value.
The deliverable will be funded space mission and a novel business model.
QUATERNARY NICOTINAMIDE DERVIATIVES AS PRECURSORS FOR RELEASE OF MNA

The invention concerns pyridine salts derivatives which are O-substituted halides of 3-oxymethylaminocarbonyl-1-methylpyridine and their pharmaceutically acceptable salts. Disclosed compounds may be used as a medicament due to observed release of the active substance - N1-methylnicotinamide (MNA) by these compounds. Preferably compounds are claimed for use in the treatment or prevention of diseases associated with endothelial dysfunction. The invention also concerns the method of MNA release and the use of pyridine salts derivatives for selective release of MNA.
Does urbanization lead to less residential energy consumption? A comparative study of 136 countries

The impact of urbanization on residential energy consumption is insufficiently understood. By employing a panel dataset of 136 countries during 1990–2015, this study examines the influence of urbanization on residential energy use worldwide, and how the magnitudes of influence vary across regions by taking into account regional heterogeneity and stages of urbanization. Our findings indicate that the impact of urbanization on residential energy consumption tends to vary greatly across regions in different urbanization stages. Most countries in Sub-Saharan Africa are at the acceleration stage of urbanization characterized by rapid population migration to urban areas without the corresponding economic growth. This feature of urbanization leads to a decrease in aggregate consumption. In contrast, the urbanization in developing regions in Asia and the Middle East & North Africa, which has been accompanied by booming economies, can increase aggregate residential energy consumption. Surprisingly, for highly urbanized regions, including the developed regions of the world, Latin America & the Caribbean, and the developing regions in Europe & Central Asia, the urbanzation impact seemingly becomes nonsignificant because of the narrow gap between urban and rural energy use in the residential sector. Based on these findings, we make four key policy suggections, including evaluating fiscal sustainability of household energy transition programs on a cost-benefit basis, developing a suite of customized options for household energy use and orderly transition process, encouraging bottom-up initiatives for adopting clean energy in residential sector, and sharing a public monitoring and planning platform. • The impact of urbanization on residential energy consumption (REC) varies greatly across the world. • Rapid urbanization without corresponding economic growth likely leads to the decrease in aggregate REC. • Urbanization accompanied by booming economy, can increase aggregate REC. • For highly urbanized regions, the impact of urbanization on REC seems nonsignificant.
CONFIGURABLE DATA PATH FOR MEMORY MODULES

Systems and methods are described to enable a memory device integrated in a memory module or system to disable one or more data bits, nibbles or bytes of the memory device., The memory device can be further configured to disable error or redundancy checking associated with the disabled data bits, nibbles or bytes, to mask errors associated with the disabled data bits, nibbles or bytes, and/or to suppress the refresh of portions of a memory array associated with the disabled data bits, nibbles or bytes.
The role of anxiety in binge eating behavior: a critical examination of theory and empirical literature

The purpose of this manuscript is to expand the understanding of binge eating by reviewing the role of aspects of negative affect. Specifically, this paper will present evidence for further investigation of the bearing that anxiety may have in binge eating development and maintenance. A comprehensive review of the literature regarding the relation of binge eating and anxiety was performed. Valuable contributions have been made to the binge eating literature regarding some aspects of negative affect (&lt;em&gt;i.e.,&lt;/em&gt; depression); however, outside of bulimia nervosa studies, much of the theoretical and empirical binge eating research to date has not directly addressed the role of anxiety. Research supports expansion of investigations of negative emotionality and binge eating to include specific study of anxiety. Greater inclusivity and specificity in the unique contributions of various negative emotions may further the development of temporal models and intervention efforts.
Four-Dimensional monitoring of tumour growth by surface enhanced raman scattering

Optical bioimaging is limited by visible light penetration depth and stability of fluorescent dyes over extended periods of time. Surface enhanced Raman scattering (SERS) offers the possibility to overcome these drawbacks, through SERS-encoded nanoparticle tags, which can be excited with near-IR light (within the biological transparency window), providing high intensity, stable, multiplexed signals. SERS can also be used to monitor relevant bioanalytes within cells and tissues, during the development of diseases, such as tumours. In 4DBIOSERS we shall combine both capabilities of SERS, to go well beyond the current state of the art, by building three-dimensional scaffolds that support tissue (tumour) growth within a controlled environment, so that not only the fate of each (SERS-labelled) cell within the tumour can be monitored in real time (thus adding a fourth dimension to SERS bioimaging), but also recording the release of tumour metabolites and other indicators of cellular activity. Although 4DBIOSERS can be applied to a variety of diseases, we shall focus on cancer, melanoma and breast cancer in particular, as these are readily accessible by optical methods. We aim at acquiring a better understanding of tumour growth and dynamics, while avoiding animal experimentation. 3D printing will be used to generate hybrid scaffolds where tumour and healthy cells will be co-incubated to simulate a more realistic environment, thus going well beyond the potential of 2D cell cultures. Each cell type will be encoded with ultra-bright SERS tags, so that real-time monitoring can be achieved by confocal SERS microscopy. Tumour development will be correlated with simultaneous detection of various cancer biomarkers, during standard conditions and upon addition of selected drugs. The scope of 4DBIOSERS is multidisciplinary, as it involves the design of high-end nanocomposites, development of 3D cell culture models and optimization of emerging SERS tomography methods.
Computational random multiscale problems

Geometrically or statistically heterogeneous microstructures and high physical contrast are the key to astonishing physical phenomena such as invisibility cloaking with metamaterials or the localization of quantum waves in disordered media. Due to the complex experimental observation of such processes, numerical simulation has very high potential for their understanding and control. However, the underlying mathematical models of random partial differential equations are characterized by a complex interplay of effects on many non-separable or even a continuum of characteristic scales. The attempt to resolve them in a direct numerical simulation easily exceeds today's computing resources by multiple orders of magnitude. The simulation of physical phenomena from multiscale models, hence, requires a new generation of computational multiscale methods that accounts for randomness and disorder in a hierarchical and adaptive fashion. 

This proposal concerns the design and numerical analysis of such methods. The main goals are connected to fundamental mathematical and algorithmic challenges at the intersection of multiscale modeling and simulation, uncertainty quantification and computational physics:

(A) Numerical stochastic homogenization beyond stationarity and ergodicity,
(B) Uncertainty quantification in truly high-dimensional parameter space, 
(C) Computational multiscale scattering in random heterogeneous media,
(D) Numerical prediction of Anderson localization and quantum phase transitions.

These objectives base upon recent breakthroughs of deterministic numerical homogenization beyond periodicity and scale separation and its deep links to seemingly unrelated theories ranging all the way from domain decomposition to information games and their Bayesian interpretation. It is this surprising nexus of classical and probabilistic numerics that clears the way to the envisioned new computational paradigm for multiscale problems at randomness and disorder.