SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Therapeutic molecules and druggable sites to suppress aberrant ion channel activity in cancer.

TASK-3 is a potassium channel member of the recently discovered two-pore potassium channels family (K2P) responsible for the background current maintaining the membrane resting potential. TASK-3 is involved in several neurological diseases but recent studies pointed out its oncogenic potential. TASK-3 aberrant expression was detected in breast, lung and colorectal cancer cells. This research proposal aims at 1) generate antibodies that can directly reduce TASK-3 function. The potency, the binding mode of the best antibodies will be characterized functionally and structurally to provide an atomic-resolution view of the mechanism of binding, paving the way for antibody engineering. The structural approach will also produce the three-dimensional structure of TASK-3, which will deepen our understanding on the biophysical properties of this channel and its involvement in several other pathologies. 2) Reduce TASK-3 activity by understanding the molecular basis of its trafficking to the membrane. The project aims at providing a structural and functional analysis of the complex between TASK-3 and the cation cotrasporter KCC2, a recently identified partner that affect TASK-3 trafficking to the membrane. Structural information on the complex will uncover regions of the channel involved in binding protein partners, opening the possibility of  pursuing these protein-protein interactions surfaces as targets for drug discovery, with the ultimate goal of modulating ion channel activity. I will undertake a multidisciplinary study that spans protein biochemistry, structural biology, electrophysiology and antibody engineering. The project tackles – side by side - basic science questions (ion channel structure and regulation) and translational research (antibody-based therapy). It offers a molecular understanding of the structural and biophysical properties of TASK-3 -currently unavailable- and opens the venue to the therapeutic targeting of this ion channel.
Method and apparatus for encoding geometry patterns, and method and apparatus for decoding geometry patterns

3D models often have a large number of small to medium sized connected components, with small numbers of large triangles, often with arbitrary connectivity. The efficiency of compact representation of large multi-component 3D models can be improved by detecting and representing similarities between components thereof, even if the components are not exactly equal. The invention uses displacement maps for encoding two or more different but similar geometry patterns differentially, based on clustering and a cluster representative surface (CRS). A method for encoding a plurality of geometry patterns comprises detecting and encoding identical copies of geometrical patterns (100), detecting and clustering similar geometry patterns (200), and detecting partial similarity (300). The detecting partial similarity (300) comprises generating a cluster representative surface, generating for at least one clustered geometry pattern a displacement map, and encoding the common surface and the displacement maps.
Observation of split modes from the 26th December 2004 Sumatra-Andaman mega-event

Abstract The high quality of the records obtained after the huge Sumatra-Andaman earthquake of December 2004 from the broad-band seismological stations of all FDSN networks offers unique opportunity for studying the free oscillations of the Earth and consequently the behavior of some particular modes. The observation and clear identification of singlets of the gravest seismic normal modes (frequencies lower than 1 mHz) and of some particular anomalously split modes should offer strong constraints on Earth structure. We carefully analyzed 23 different modes and report the detailed results of 17 of them, showing an enhancement on the eigenfrequencies determination thanks to the high SNR (Signal to Noise Ratio) of the recordings. We analyzed vertical component recordings but also additional horizontal components. We present modal frequency measurements of some spheroidal fundamental gravest modes, of some particular higher modes such as inner core modes exhibiting normal or anomalous splitting. The results are compared with the theoretical eigenfrequencies computed for the PREM model, taking into account both rotation and ellipticity effects of the Earth and lateral heterogeneities of the SAW12D model ( Li and Romanowicz, 1996 ). The misfit between measured and theoretical eigenfrequencies point out that some physical parameters are not well constrained. The new catalogue of modal eigenfrequencies provided from the Sumatra-Andaman 2004 event analysis offers a plethora of perspectives; it is an important step towards the resolution of deep Earth parameters.
A Market-Based Transmission Planning for HVDC Grid—Case Study of the North Sea

There is significant interest in building HVDC transmission to carry out transnational power exchange and deliver cheaper electricity from renewable energy sources which are located far from the load centers. This paper presents a market-based approach to solve a long-term TEP for meshed VSC-HVDC grids that connect regional markets. This is in general a nonlinear, non-convex large-scale optimization problem with high computational burden, partly due to the many combinations of wind and load that become possible. We developed a two-step iterative algorithm that first selects a subset of operating hours using a clustering technique, and then seeks to maximize the social welfare of all regions and minimize the investment capital of transmission infrastructure subject to technical and economic constraints. The outcome of the optimization is an optimal grid design with a topology and transmission capacities that results in congestion revenue paying off investment by the end the project's economic lifetime. Approximations are made to allow an analytical solution to the problem and demonstrate that an HVDC pricing mechanism can be consistent with an AC counterpart. The model is used to investigate development of the offshore grid in the North Sea. Simulation results are interpreted in economic terms and show the effectiveness of our proposed two-step approach.
Biphasic heat transport integration for efficient heat exchange within composite materials nacelle

BISANCE intends at defining a biphasic system integrated into a full composite nacelle and engine air intake. The biphasic system aims at decreasing significantly the weight, the environmatal footprint as well as the space allocated by the current active systems for the cooling of the engine oil and for the energy supply of th ice protection systems. These both active systems (needing external power) will be replaced by a biphasic passive system (autonomous with no need of external power) which will extract the energy from the engine oil and transfer it to the ice protected surfaces.
The objective of the project is thus to decrease the weight by 25kg for the two nacelles of a turboprop A/C, to decrease the CO2 emissions by almost 900 000 kg per AC life and to save 200 000$ of operating costs per AC life.
The project will be divided into 5 workpackages along 30 months. The first step intends at defining the specifications and the requirements of the product. Based on the requirements, several concepts of system integration into the structure  will be proposed and manufactured for selecting the most promising one. Qualification tests are expected for characterizing the structural resistance and stifness of the concept, for verifying the resistance to heat cycles and to impacts. Finally a fulls scale demonstrator will  be manufactured for testing it in icing Wind tunnel.
The project will be coordinated by Sonaca, also in charge of the structural developments, in association with Calyos, in charge of the system developments and with RTA  in charge of performing the icing wind tunnel testing.
Multifunctional 4-bit biomemory chip consisting of recombinant azurin variants

We developed a multi-functional 4-bit biomemory chip that consisted of recombinant azurin variants. The azurin was modified to introduce cysteine-residues. In addition, the Cu ion in this recombinant azurin protein was substituted with various other metal ions such as Co, Mn, Fe and Ni ion to allow the protein to perform various memory functions. Each metal-substituted recombinant protein was directly self-assembled attached onto Au surface via the thiol group of the cysteine. UV-VIS spectroscopy was performed to confirm the metal substitution. Atomic force microscopy was used to measure the film organization. Also, the 4 different azurin variants were investigated to assess the electrochemical behavior. Cyclic voltammetry and an open circuit potential indicated that the azurin variants had different redox peaks and specific open circuit potential values. Using these parameters, memory function was verified by chronoamperometry and open circuit potential amperometry. Therefore, a multi-bit biomemory chip was successfully developed. The results presented here provide a new approach, concept and material combination for the development of biomemory systems using recombinant protein. If a low electrochemical signal from a few single proteins could be achieved, it may be possible to substitute silicon-based memory devices with biological-based memory devices.
Le politiche urbane del cibo come possibile arena per la governance climatica urbana

Nel dibattito sulla sostenibilit&amp;agrave; urbana hanno assunto un ruolo crescente, da circa vent'anni a questa parte, le cosiddette politiche urbane del cibo (PUC), che mirano a ridurre gli impatti ambientali e aumentare la giustizia socio-spaziale dei sistemi alimentari, agendo alla scala urbana. Tali politiche costituiscono secondo alcuni un ambito di grande potenzialit&amp;agrave; per la governance climatica urbana, grazie alla possibilit&amp;agrave; di agire sul consumo alimentare delle popolazioni urbane, che costituisce uno dei principali fattori di impatto ambientale su scala globale. Non mancano tuttavia le riflessioni critiche, relative alla realecapacit&amp;agrave; di azioni e politiche localizzate di modificare strutturalmente sistemi del cibo complessi. Questo contributo si interroga sul possibile ruolo delle PUC nel quadro della governance climatica urbana, a partire dall'analisi delle realt&amp;agrave; presenti all'interno della Rete Italiana Politiche Locali del Cibo e con un approfondimento sui casi di Roma e Milano.
FACILITATING INTERACTION WITH A COMPUTING DEVICE BASED ON FORCE OF TOUCH

A technique is described herein that allows a user to control a user interface presentation provided by a computing device based on a force-dependent manner in which the user engages a surface of a force-sensitive input device. This manner of control allows any user to efficiently interact with the computing device, but is particularly beneficial to users who have motor-related and/or vision-related disabilities.
Adhesion multiphysics of rubberised asphalt binders

AMRAB aims to train a talented research Fellow through an interdisciplinary project focused on modelling the coupled adhesion multiphysics in the interfacial zone between crumb rubber modified binders (CRMB) and mineral aggregates under various environmental conditions. The primary deliverables of the project include a fundamental understanding of adhesion mechanisms, an accurate prediction framework and evaluation protocol for the adhesive properties of CRMB, and an implementation of industrial adhesion promoters and technologies in rubberised road construction. The Fellow will receive intensive technical training from both academic and industrial hosts, which will substantially extend his expertise from construction asphalt materials to a multidisciplinary field of chemistry (UoN), mechanics and computational modelling (Aston and KTH), experimental characterisation (UoN and RWTH) and road engineering applications (Total and AI). The Fellow will also receive inter-sectoral and professional skills training in project management, outreach, networking, and intellectual property protection. The benefits brought by AMRAB is represented by strengthening the EU industry leadership in adhesive material innovation and aiding the EU engineers in rubberised asphalt material selections, road structural design, and techno-economic analysis. The implementation of adhesion promoters and technologies for CRMB in rubberised road infrastructures will extend the road service life, increase the recycling of waste tires, and ultimately reduce the greenhouse gas emissions and consumption of petroleum bitumen. Uniquely, the project will enable the Fellow to obtain interdisciplinary knowledge and inter-sectoral complementary skills by building a new and exciting research field, which will pave a solid foundation for the Fellow towards his career of being an independent expert researcher in the areas of infrastructure sustainability and construction materials at a top European university.
Antioxidant activity of hydroalcholic extract of Ferula gummosa Boiss roots

Objectives: Ferula gummosa Boiss is native to central Asia. This plant has traditionally been used in the treatment of many diseases. The antihypoxic and antioxi- dant activities of Ferula gummosa roots were investigated. Material and Methods: 1,1-diphenyl-2- picryl hydrazyl radical (DPPH), nitric oxide and hydrogen peroxide scavenging activities, Fe 2+ chelating ability, reducing power and hemoglo- bin-induced linoleic acid peroxidation were used to evaluate antioxidant activities. Antihe- molytic activity was evaluated by H2O2 induced hemolysis in rat erythrocytes. The total amount of phenolic compounds was determined as gal- lic acid equivalents and total flavonoid con- tents were calculated as quercetin equivalents from a calibration curve. Results: The extracts showed moderate an- tioxidant activity in some models. IC50 for DPPH radical-scavenging activity was 579.6±19.4 µg/ml. The extracts showed weak nitric oxide- scavenging activity between 0.1 and 1.6 mg ml -1 but showed good Fe 2+ chelating ability. IC50 was 895.5±24.1 µg/ml. The extract also ex- hibited low antioxidant activity in the linoleic acid model but were capable of scavenging hydrogen peroxide in a concentration depen- dent manner. Tested extract show moderate activity in H2O2 induced hemolysis in rat ery- throcytes which was not comparable with vita- min C. Conclusions: F. gummosa Boiss root showed different level antioxidant and antihemolytic ac- tivities. Biological effects may be attributed, at least in part, to the presence of phenols and flavonoids in the extract.
Prioritise energy efficiency (EE) measures in public buildings: a decision support tool for regional and local public authorities

PrioritEE aims at reinforcing the capacities of public administrations in selecting and implementing eco-friendly and cost-effective energy planning measures to support their decision making and accelerate the implementation of the EED. This aim will be pursued working in close cooperation with public local authorities focusing on three main pillars: capacity building, development of decision making support tools, and transfer of knowledge. 5 pilot cases will be developed in different cities of the partners countries (Italy, Portugal, Spain, Greece and Croatia) to determine and monitor energy consumption in public buildings and the resulting greenhouse gas emissions, comparing the effects of different policies strategies. The transfer of knowledge will be developed integrating participatory and practical capacity building activities through collaborative learning schemes within each country and between the partner local authorities to focus on actual short-term implementation of EE policies and measures with a strategic long-term perspective. The main foreseen output is a set of local plans and methods to prioritise the EE investments in public buildings and to foster the adoption of EE good practices. The main expected results for local public administrations are a common data set for establishing benchmarks and priorities, a measurement and verification framework to estimate the level of energy, costs and CO2 emission savings achieved, priority lists of EE investments.
CONFECTIONERY PRODUCTS HAVING LIQUID CENTERS

Confectionery products comprising liquid centers and methods for making same are provided. In an embodiment, the present invention provides a confectionery product comprising a confectionery shell surrounding at least one liquid filled bead.
Molecular mechanisms of the mechanical interaction between the cell nucleus and the actin cytoskeleton

The cytoskeleton plays a pivotal role in growth, development, and disease by sensing mechanical stress and mediating structural remodeling and cell functional responses. The cytoskeleton, which is linked directly to the nuclear lamina and thereby to chromatin, has recently been proposed to impact on chromatin remodeling and transcriptional activity. However, the mechanisms and biological consequences of force-dependent chromatin remodeling have remained elusive. Within this context main goals for my project are 1) to characterize nuclear rheology and stress transmission over the nuclear-cytoskeletal linkage, 2) to identify molecular mechanisms of force transmission into the nucleus and 3) to develop a numerical model of cell contractility and remodeling to systematically and quantitatively investigate the stress transmission to the nucleus to test my hypothesis that global force application to the nucleus can control nuclear mechanics, chromatin structure and transcriptional activity in a predictable, biologically meaningful way.
This interdisciplinary project, integrating both cell/molecular biology of genome regulation and bioengineering, will advance our understanding of cellular mechanosensing and mechanotransduction, and carries therefore a strong transformative potential for discovering new strategies to mitigate many diseases where the interplay of mechanics and biochemistry are critical.
Analysis and implementation of a novel robust transmission scheme for private digital communications using Arduino Uno board

In this paper, we present a new scheme for the secured transmission of discrete information based on hyperchaotic discrete dynamics. The system is a modified-Henon hyperchaotic discrete-time oscillator considered as transmitter and a delayed step-by-step observer used as receiver. The transmitter parameters play the role of secret keys of the transmission scheme. To increase the robustness of the secure data transmission against known plain-text attacks, the message to be sent is encrypted by additional secret keys and inserted by inclusion method in the chaotic discrete-time system dynamics. By this way, the parameters used as secret keys cannot be identified with usual techniques. Simulation results are presented to highlight the performances of the proposed method. One of the main contributions of this paper is to demonstrate the feasibility of discrete realization of a chaotic observer-based secured transmission scheme. Indeed, experimental implementation results using Arduino Uno board validate the proposed approach, since it exhibits good performances of throughput and cost in terms of resources used.
Etching processing method

The etching processing method is characterized in that, when performing an etching processing on a resin member by using a desmear liquid containing an alkaline permanganate etching liquid, the etching processing is performed by dipping the resin member into the desmear liquid of which an etching rate for a resin forming the resin member is adjusted by using at least one of an accelerator for accelerating the etching rate of the desmear liquid and a suppressor for suppressing the etching rate.
Status of karnal bunt in wheat seed produced in Haryana

The survey was carried out in eight districts of Haryana to find out status of Karnal bunt in unprocessed wheat seed produced by public and private seed producers during rabi season of 2012–13. The results revealed that out of 410 samples, only 181 samples (44.14%) were found infected with Karnal bunt. The overall range of infection was observed 0.05 – 6.40% which is exceeding the permissible limit of IMSCS for quality seed production. The overall 0.170% average infection was recorded, the maximum in Karnal (0.462%) followed by Jind (0.265%) and minimum in Sirsa (0.015%) followed by Panipat (0.045%). Out of 410 samples, the maximum percentage of infection was found in the samples collected from Karnal (69.23%) followed by Jind (57.84%), Panipat (50.00%), Kurukshetra (41.66%) and Kaithal (40.90%) districts, whereas minimum percentage were in Yamunanagar (16.21%) followed by Sirsa (17.39%). Among varieties, C-306 recorded the maximum average infection (0.488%) whose eight samples were collected from Hisar and one from Jind district followed by HD-2285 (0.366%) and PBW-343 (0.357%). Whereas, minimum average infection were found in WH-711 (0.014%) followed by DBW-17 (0.040%). The variety PBW-343 was recorded with highest range of infection (0.25–6.40%) in Karnal. None of the district and variety was found free from Karnal bunt.
Hystrix primigenia (Wagner, 1848) (Rodentia, Mammalia) del Mioceno Superior (MN 13) de Las Casiones (Fosa de Teruel, España)

Se estudian los restos de puercoespines procedentes del yacimiento de! Mioceno Superior (Turoliense superior,MN 13) de Las Casiones, en la provincia de Teruel, España. Se han identificado como pertenecientes a Hystrixprimigenia (Wagner, i848), en función de la gran tala y del caracter relativamente braquiodonto de ia dentición.Los fósiles de Las Casiones constituyen el conjunto más abundante y mejor representado de restos de dichaespecie en España. En el presente trabajo se determina asimismo el material de Hystrix sp. de Venta del Moro(también de la MN 13) como H. primigenia. Todo esto se halla en consonancia con la hipótesis de la entrada deH. primigenia durante el Turoliense superior en la Península lbérica, donde permanece al menos hasta elPlioceno Superior (Villarroya, La Rioja); esta última es una de las citas mas modernas en el registro fósil de laespecie.
Granitos rapakivi e rochas associadas da Suíte Intrusiva São Lourenço-Caripunas (1,32 – 1,30 Ga) no distrito mineiro São Lourenço- Macisa, NW da Província Estanífera de Rondônia: I - Petrografia das fácies precoces e evidências de interação de magmas

A Suíte Intrusiva São Lourenço-Caripunas (1,32 – 1,30 Ga), na região do distrito mineiro São Lourenço-Macisa (NW da Província Estanífera de Rondônia), inclui granitos rapakivi e rochas associadas, que são reunidas em quatro unidades ígneas mapeadas na escala 1:25.000. A Unidade A é composta de viborgitos e piterlitos com hornblenda e biotita, e biotita granitos seriados; a Unidade B, de granitos pórfiros com hornblenda e/ou biotita; a Unidade C, de gabros, microgabros, hornblenda quartzo-monzonitos e granitos pórfiros; e a Unidade D, de biotita granitos seriados e equigranulares. Os litotipos das unidades A, B e C são interpretados como intrusões precoces, e os litotipos da Unidade D, como intrusões tardias e relacionadas espacialmente com os depósitos primários de estanho e metais associados. Algumas fácies petrográficas da fase precoce apresentam assembleias de minerais e texturas que indicam a atuação de processos de interação de magmas mais máficos e mais félsicos na origem dessas rochas.