SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Immune-Privileged, immortal, myogenic stem cells for gene therapy of muscular dystrophy.

Duchenne muscular dystrophy (DMD) is a devastating incurable disease, affecting thousands with heavy burden on health systems. This project combines the development of a safe, “immune-privileged cell” with genetic engineering to correct many dystrophin gene mutations for an efficacious and cost affordable therapy. The applicant pioneered systemic intra-arterial transplantation of mesoangioblasts (blood vessel-derived progenitors) that proved safe in DMD patients and is being implemented for efficacy. However, this personalised approach would prove prohibitively expensive for healthcare systems, as pricing of successful gene therapies is showing. We made the striking observation that human mesoangioblasts can be indefinitely expanded with a novel culture medium, even after genetic manipulation and cloning. Cells will be first genome edited to delete endogenous HLA (β2-microglubin and class II CTA) while inserting tolerogenic HLA-E, fused to β2-microglubin and, as safety device, the Herpes Simplex Thymidine Kinase suicide gene with truncated NGF receptor for selection. Edited clones will be checked for genome integrity.  Selected clones will be engineered to express a small nuclear RNA (snRNA) that causes skipping of a given exon of the dystrophin gene. Due to the syncytial nature of muscle fibres, the snRNA also enters and corrects the genetic defect in neighbouring, dystrophic nuclei, thus amplifying of one log the therapeutic effect. Five different cell lines would correct the mutation in 60% of DMD patients.  The cell lines will be transplanted in humanized DMD mice and assessed for the ability to escape immune surveillance and to differentiate in dystrophin expressing myofibers, establishing pre-clinical safety and efficacy for an off the shelf, affordable product. The applicant has unique expertise to successfully complete this project, whose strategy may be expanded to other recessive monogenic diseases, for a ground breaking impact in regenerative medicine.
SUNRISE - Cohésion sociale dans les zones urbaines/rurales basée sur services collectifs de mobilité innovateurs et durables.

Changes in lifestyle and mobility service needs, when compared to the current facilities provided in towns and cities, show that there are different mobility demands that conventional public transport, with its rigid routes and timetables, does not satisfy. The introduction of complementary services, like Demand Responsive Transport (DRT), may provide a response to these new needs. In recent years, DRT’s collective services have brought significant advantages to many groups of citizens in different European towns, regions and rural areas. At this point it is necessary to use the accumulated results, experiences and practices in order to implement and test the DRT concept in many European regions, to estimate its effects in terms of mobility, social cohesion, environmental protection, and to assemble the good practices and results it will provide. Thanks to the experience acquired by certain project partners in this type of services, SUNRISE will ensure that DRT frameworks are established in many localities and promoted at European level. Overall objective / Objectif général SUNRISE aims to provide different European areas with the assembled technological, operational and organizational experience about DRT services in order to develop transport at regional level. The project will enable the organisation and implementation of feasibility studies, the testing of DRT services within the SUNRISE environment, and to evaluate the impact on organisation, mobility, viability and social cohesion. In addition, the transport authorities and operators will be assisted in evaluating the opportunity to use DRT solutions, and in consolidating the good practices provided. Expected results / Résultats attendus The expected results of the SUNRISE project are as follows: • Transfer of experiences to all partners from those who are most advanced in the area of DRT, for new projects (as in the case of the Serres prefecture, which will implement the first DRT system in Macedonia), or for improving existing systems as in the cases of CAT and RAL. • A dynamic internet site which shows the project’s progress according to the planned programme, together with the most important project documents and reports. • A discussion forum on the project website that can be accessed by public authorities, users and operators. • An internal quality organisation plan. • Two brochures, an e-newsletters and posters to present the project. • A handbook describing the guidelines for the establishment and management of DRT services in Europe. • Creation of links with other important European and national programmes, associations and projects. • A specific workshop for politicians and local authorities, public transport companies and public organisations. • Participation in the most important conferences and press releases.
Derivation and Application of a Mathematical Model for Long Bone Growth

The objective of this work was to develop a mathematical model of long bone growth and to gain insights regarding growth disorders. A cell balance (mass balance of moving cells) assessment was performed on the three regions of the growth plate, to determine the variables (including number of proliferating cells, and division rate of proliferating cells) that influence tibia growth rate. Once this relationship was established, clinical data were used to understand how tibia growth rate and number of proliferating cells change with time. These equations were then inserted into the model to determine how cell division rate changes with time. The model was utilized to determine the influence of growth time, and to measure changes in vitamin C deficiency, Indian hedgehog (IHH) expression, and bone morphogenetic protein-2 (BMP-2) implants on tibia length. According to the model, a 10-month discrepancy in growth time between the two tibias is required to produce clinically significant leg asymmetry. In addition, vitamin C deficiency, IHH overexpression, and BMP-2 implants can all affect tibia length. These bioactive molecules have the greatest effect on tibia growth rate when these perturbations occur early in life for extended periods of time. The results are significant for modeling and predicting the effects of perturbations, including bioactive implants, on long bone growth.
Robo Advisors vs. Value Investing Strategies: A Fuzzy Jensen’s Alpha Assessment

Robo-advisor (RA) platforms have become fundamental in the areas of finance and technology, as they have revolutionized the way investments are carried out and managed. Nevertheless, investment strategies using traditional financial management are currently being maintained. The objective of this research is to compare an investment portfolio that utilizes similar strategies to those of a RA against an investment portfolio that makes decisions through a consensus of valuation analysts. Fuzzy Jensen’s Alpha is used to compare both portfolios. To create a new portfolio strategy proposal for RA platform as well as a value investing portfolio, we selected Latin American listed companies in Mexico, Colombia, Peru, Chile, and Brazil for the sample. Additionally, we used ETFs to replicate those countries. The timespan considered was from January 15, 2015 to June 28, 2019. The results report that both strategies succeeded in surpassing the benchmark; however, the analysts’ portfolio has accelerated its growth since 2018, increasing its positive gap against the RA portfolio. In this sense, the portfolio developed by the analysts gives an average return higher than the average return of the RA. Nonetheless, the RA portfolio has a higher possibility of obtaining abnormal or unexpected returns than the analyst's value investing portfolio, given the systematic risk involved.
ADHA

Data layouts play a crucial role in determining the performance of a given application running on a given architecture. Existing parallel programming frameworks for both multicore and heterogeneous systems leave the onus of selecting a data layout to the programmer. Therefore, shifting the burden of data layout selection to optimizing compilers can greatly enhance programmer productivity and application performance. In this work, we introduce ADHA: a two-level hierarchal formulation of the data layout problem for modern heterogeneous architectures. We have created a reference implementation of ADHA in the Heterogeneous Habanero-C (H2C) parallel programming system. ADHA shows significant performance benefits of up to 6.92× compared to manually specified layouts for two benchmark programs running on a CPU+GPU heterogeneous platform.
Point-Of-Care molecular diagnostics of psoriasis and eczema – pelabdisk

Innovative and effective biological therapies exist to treat non-communicable inflammatory skin diseases (ncISD). However, diagnostic guidance when and how to use them is imprecise; no substantial innovation was made for decades. Due to this lack of innovation, high socio-economic costs are caused by ineffective unguided treatment – a waste of resources. Existing ERC research aims at establishing individualised medicine in ncISD (IMCIS, grant agreement 676858). First success is a biomarker to distinguish psoriasis from eczema. Due to disease heterogeneity, these two ncISD cannot be distinguished in 10% of all cases with current gold standard diagnostics. Treating patients with the wrong therapy as a consequence of mis-diagnosis is inefficient and might even be harmful. This PoC proposal follows the path of IMCIS and closes the gap between ERC research and a prototype device of a point-of-care microfluidic testing device to distinguish psoriasis and eczema based on their molecular signature (peLabDisk). The proposal is feasible, as there is a high level of expertise created by joint forces of researchers of the Technical University of Munich and Hahn-Schickard providing extensive competence in the development, construction and manufacturing of microfluidic cartridges for medical applications. The project plan consists of well-defined work packages and milestones. Furthermore, success of the individual work packages is supervised by experienced experts (TUM Entrepeneurship). This PoC proposal is not the end – there is a clear roadmap and a detailed strategy for the post-PoC phase including potential end-user network and supported foundation of a spin-off company. peLabDisk represents the first approach of molecular diagnostics in the field that is easy-to-handle, robust and valid, as well as economic. It is superior to current gold standard diagnostics. Furthermore, peLabDisk is a use-case for point-of-care molecular diagnostics in complex inflammatory diseases.
Angels in the Dust (2007)

Angels in the Dust (2007) Directed by Louise Hogarth Distributed by Cinemalibre Studios www.cinemalibrestudio.com 95 min. Winner of numerous awards, including the Special Jury Prize for Best Documentary, at the 2007 Seattle International Film Festival, Angels in the Dust chronicles the plight of South African children whose lives have become collateral damage of the AIDS crisis, orphaned at an early age because of the death of their parents and extended members from HIV/ AIDS. Produced by Louise Hogarth, who also co-produced the 1 994 Academy Award- winning documentary film, The Panama Deception, the film is a two hour- plus journey into the life of Marion Cloete and the orphanage she and her established in Boikarabelo to care for South African children, who were, or were about to be, orphaned. The film opens with a grim image and a parable: We see hunters in helicopters killing adult elephants, leaving their young without mums and dads. When the young elephants are removed from the wild, for protection and care, it is discovered that they cry at night. And as they continue to grow without parental guidance, they exhibit socialization problems, both within their cohort and with other species. A decision is made to reintroduce adult elephants with the young elephants, in the hope that the adults will teach and guide them, and indeed, the plan works. The message this narrative imparts serves as model for another orphan story in search of a happy ending - the story of a woman working with human orphans - the story of Marion Cloete. Cloete, a trained therapist, moved with her husband, Con, and two daughters to Moyaliesberg 19 years ago, using all their savings to open a school and orphanage. The sign in front of their facility reads Botshadbeo: A Child's Sanctuary. Here Marion and her raise and care for over 500 children of the region, most of whom have been orphaned, and are, here, reintroduced to a family setting, with Marion serving as the matriarch, nurturer, care-provider, and counselor for all of the children. Not only are the young ones provided for in a psychological sense, but they are taught the values, norms, and behaviors of everyday life - a life structured by a pattern of meals, school, recreation time, and chores - which will enable them to function, one day, in families of their own. Cloete also brings a strong spiritual dimension to her work with the children, seeing hope and faith as critical elements in the process of rehabilitation. This focus is integrated into the context of the film with careful and skilled timing and exposition, and generally avoids slipping into didacticism. There are many storylines within the film itself, introducing the viewer to village life, and the stories of several young girls, in an effort to illustrate why the Cloete facility was so desperately needed. The girls' tragic, but typical, lives include stories of starvation, neglect, abuse, rape, incest, and prostitution, often becoming tools in their parents' desperate struggles for survival. …
Literatura y educación femenina: el caso de Leticia Valle

El propósito de este artículo es analizar, a través del relato de Rosa Chacel Memorias de Leticia Valle el proceso educativo de una joven preadolescente en contextos formales y no formales en la España de la primera década del s. XX. El comportamiento del personaje femenino evidencia al lector a lo largo de este relato que una educación intelectual no es suficiente para la maduración de la personalidad; debe ir acompañada de un adecuado cultivo de la dimensión afectiva, de la comunicación interpersonal en un ambiente de confianza y de la comprensión de los posibles conflictos interiores para resolverlos durante su crecimiento. Asimismo, el texto narrativo de Rosa Chacel refleja que una relación equilibrada entre educador y educando constituye la base del éxito en la enseñanza-aprendizaje. Como conclusión del análisis de la novela y de su personaje femenino protagonista, consideramos que los textos literarios pueden convertirse para el docente en un medio excelente para mostrar modelos educativos que sirvan de análisis y referente para la educación integral del alumno en la escuela del s. XXI.
Cell collaborative zones for 4G cellular systems

In this paper, we consider the multiple base station cooperative transmission, a new technology being developed to lift the interference limits on wireless network. In practice, the biggest challenge facing multiple base station collaboration is the stringent requirement of the high-speed backbone to enable information exchange, especially for large deployment. We address this backbone issue and propose to define a collaborative zone within each cell. Only those users within the collaborative zone will be served by multiple coordinated base stations. Whereas users outside the collaborative zone will be served by a single base station as in a conventional non-collaborative scheme. The criterion defining the collaborative zone is proposed and designed in such a way that the users outside the collaborative zone sacrifice only marginal potential collaboration gain in terms of achievable rates. Since the amount of information to be exchanged will be a square function of the number of users served by the collaborative base stations, the introduction of the collaborative zone can reduce the backhaul overhead significantly.
Implementation of technology for building and sharing complex data stream processing services from wearables devices by Cubatex Sp. z o.o. in Włocławek in partnership with Auction Ventures Sp. z o.o.

The aim of the project is to implement the results of R & D work on the development of platform technology allowing the construction and provision of complex data stream processing services. The sources of data streams processed by the platform are sensors and wearables and their virtual representations, forming so-called. The Internet of Things. The platform concept developed by the applicant in R & D is a paradigm for the production of SOA-oriented IT systems. Service-Oriented Architecture) about the ability to transmit and process data streams and provide communication between services through an adaptable Communication Protocol. Implementation of the R & D results will enable the applicant to launch a globally innovative e-service consisting of making the platform functionality available in the SaaS model (software as a service). The project will be implemented in partnership with Auction Ventures Sp. z o.o., which will introduce a process innovation related to the implementation of a solution supporting the development of embedded wearables software, optimised for cloud communication, in particular with the applicant’s platform. This solution will be a software component using an adaptable Communication Protocol, supporting the proper interpretation of the transmitted data streams.Implementation of the results of R & D works by the applicant requires the purchase of:- a dedicated IT system of a platform allowing the construction and provision of complex data stream processing services,- server infrastructure (server and power supply UPS) supporting the provision of e-service,- 4 portable computers necessary for the provision of e-service by the employed personnel,
Floodplain Paleosols of Moskva River Basin: Chronology and Paleoenvironment

ABSTRACT Seven main periods of soil formation can be distinguished in the floodplain of the Moskva (Moscow) River, with the oldest paleosols dated to the Allerød age. We analyzed paleosols buried under alluvial deposits, colluvial sediments, and archaeological deposits within the catchment area of the Moskva River. Paleopedological reconstructions were correlated with the results of the pedoanthracological and palynological analyses. Series of radiocarbon ( 14 C) dates were obtained on humic acids and dispersed macro-charcoal from paleosols and archaeological features. Wide time frames of the floodplain paleosol formation were determined at a 95% probability as 14,600–12,600 cal BP for Soil 7; 9500–7000 cal BP for Soils 6 and 5; 6700–5500 cal BP for Soil 4; 5000–4400 cal BP for Soil 3b; 4100–2700 cal BP for Soil 3a; and 2000–700 cal BP for Soil 2. The dates were compared with the age of archaeological sites from the same areas. The comparison revealed a close correspondence between the ages of the soil charcoal and the timing of archaeological occupations. That allowed us to conclude that the fire occurrence on a regional level was associated mainly with the human occupation. The fire record is especially pronounced in floodplain paleosols, due to both the role of rivers as human migration corridors, and the integral accumulation of combustion products from the entire catchment area in these paleosols.
Thermal maturity structures in an accretionary wedge by a numerical simulation

This study investigates the thermal maturity structure of the accretionary wedge along with the thermal history of sediments during wedge formation using a numerical simulation. The thermal maturity, which is described in terms of vitrinite reflectance, is determined using the temperature and duration of exposure based on the particle trajectories within the accretionary wedge. This study revealed the variability in the thermal maturity even though sediments are observed to originate at an identical initial depth and thermal conditions. We propose two end-member pathways of sediment movement in the accretionary wedge during wedge growth: a shallow, low thermal maturity pathway and a deep, high thermal maturity pathway. These shallow path sediments, which move into the shallow portion of the wedge during wedge growth through accretion, rarely experience high temperatures; therefore, their thermal maturity is low. However, the sediments subducted in the deep portion of the wedge experience high temperatures and obtain high thermal maturity as a function of the deep high thermal maturity pathway. Simultaneously, a geological deformation event, such as faulting, defines the steps of thermal maturity. The small step of thermal maturity is formed by the frontal thrusting and can be preserved as a function of the shallow low thermal maturity pathway. However, the step is overprinted and is observed to disappear through the deep high thermal maturity pathway. The large step of thermal maturity is formed by long-term displacement along an out-of-sequence thrust (OOST) in the deep portion of the wedge.
Humans and chimpanzees attend differently to goal-directed actions

Humans comprehend the actions of others by making inferences about intentional mental states of another. However, little is known about how this capacity develops and whether this is shared with other animals. Here we show the ontogenetic and evolutionary foundations of this ability by comparing the eye movements of 8- and 12-month-old human infants, adults and chimpanzees as they watched videos presenting goal-directed and non-goal-directed actions by an actor. We find that chimpanzees anticipate action goals in the same way as do human adults. Humans and chimpanzees, however, scan goal-directed actions differently. Humans, particularly infants, refer to actors' faces significantly more than do chimpanzees. In human adults, attentional allocation to an actor's face changes as the goal-directed actions proceed. In the case of non-goal-directed actions, human adults attend less often to faces relative to goal-directed actions. These findings indicate that humans have a predisposition to observe goal-directed actions by integrating information from the actor.
Development of Lean Alloyed Austenitic Stainless Steels with Reduced Tendency to Hydrogen Environment Embrittlement

Hydrogen gas is believed to play a more important role for energy supply in future instationary and mobile applications. In most cases, metallic materials are embrittled when hydrogen atoms are dissolved interstitially into their lattice. Concerning steels, in particular the ductility of ferritic grades is degraded in the presence of hydrogen. In contrast, austenitic steels usually show a lower tendency to hydrogen embrittlement. However, the so-called “metastable” austenitic steels are prone to hydrogen environmental embrittlement (HEE), too. Here, AISI 304 type austenitic steel was tensile tested in air at ambient pressure and in a 400 bar hydrogen gas atmosphere at room temperature. The screening of different alloys in the compositional range of the AISI 304 standard was performed with the ambition to optimize alloying for hydrogen applications. The results of the mechanical tests reveal the influence of the alloying elements Cr, Ni, Mn and Si on HEE. Besides nickel, a positive influence of silicon and chromium was found. Experimental results are supported by thermodynamic equilibrium calculations concerning austenite stability and stacking fault energy. All in all, the results of this work are useful for alloy design for hydrogen applications. A concept for a lean alloyed austenitic stainless steel is finally presented.
SURFACTANT SYSTEM FOR USE IN A LIPOPHILIC FLUID

The present invention relates to a surfactant system and a consumable detergent composition comprising the same. The surfactant system is used in a lipophilic liquid and comprises from 0.1 to 30 wt. % of a silicone surfactan t, from 0.1 to 99 wt. % of a nonionic surfactant, from 0 to 50 wt. % of a gemin i surfactant and from 0 to 50 wt. % of an anionic surfactant.