SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Association between polymorphisms in transforming growth factor-β1 and sporadic Alzheimer's disease in a Chinese population

Alzheimer's disease (AD) is the most common neurodegenerative disorder of the brain. It causes the slow progressive loss of cognitive functions that ultimately leads to dementia and death in the elderly. The etiology and mechanism of late-onset AD (LOAD) are poorly understood, and genetic factors might play an important role in the development of AD. The aim of this study was to investigate the association between common polymorphisms in TGF-β1 with LOAD in a Chinese Han population. Two single nucleotide polymorphisms in TGF-β1 (rs1800469 and rs1982073) were genotyped in 202 patients with sporadic LOAD and 225 control subjects using polymerase chain reaction restriction fragment length polymorphism. Our results showed that rs1800469 in TGF-β1 were significantly associated with LOAD. The frequencies of the AC genotypes of rs1800469 were significantly higher in the LOAD patients than in the control subjects (42.5% vs 28.6%; P = 0.001). The minor allele (C) frequency was significantly higher in patients with LOAD than in control subjects (30.7% vs. 21.0%; P = 0.001). The genotypes and allele of rs1982073 in TGF-β1 were also significantly associated with LOAD. The frequency of the TG genotype of rs1982073 was significantly higher in the LOAD patients than in the control subjects (38.1% vs. 27.1%; P = 0.013). The minor allele (G) frequency was significantly higher in patients with LOAD than in control subjects (22.2% vs. 16.7%; P = 0.032). These results suggest that common variants in TGF-β1 might contribute to the development of LOAD in the Chinese population.
Role of G-protein-coupled Receptor-related Genes in Insecticide Resistance of the Mosquito, Culex quinquefasciatus

G-protein-coupled receptors regulate signal transduction pathways and play diverse and pivotal roles in the physiology of insects, however, the precise function of GPCRs in insecticide resistance remains unclear. Using quantitative RT-PCR and functional genomic methods, we, for the first time, explored the function of GPCRs and GPCR-related genes in insecticide resistance of mosquitoes, Culex quinquefasciatus. A comparison of the expression of 115 GPCR-related genes at a whole genome level between resistant and susceptible Culex mosquitoes identified one and three GPCR-related genes that were up-regulated in highly resistant Culex mosquito strains, HAmCq(G8) and MAmCq(G6), respectively. To characterize the function of these up-regulated GPCR-related genes in resistance, the up-regulated GPCR-related genes were knockdown in HAmCq(G8) and MAmCq(G6) using RNAi technique. Knockdown of these four GPCR-related genes not only decreased resistance of the mosquitoes to permethrin but also repressed the expression of four insecticide resistance-related P450 genes, suggesting the role of GPCR-related genes in resistance is involved in the regulation of resistance P450 gene expression. This results help in understanding of molecular regulation of resistance development in Cx. quinquefasciatus.
The dynamic representational nature of working memory storage

Working memory excels in keeping ready the momentary contents of all of human higher cognition despite being strictly limited in storage capacity. How the brain accomplishes this feat, beyond the temporary maintenance of just experienced information, is hardly understood. An emerging view suggests that working memory storage is topographically distributed according to the information’s endogenous level of abstraction. However, very little is known about how such distributed storage is orchestrated spatiotemporally, that is, how representations at different levels of abstraction are structured dynamically in time to suit current demands. 
In DeepStore, we use tailored experimental designs and newly developed multivariate analysis techniques to explore for the first time directly the depth-dimension of working memory storage, in terms of dynamic levels of abstraction. Combining functional imaging, magneto-/electroencephalography, and invasive neural recordings will make it possible to track levels of abstraction spatiotemporally, with millisecond precision.
In three ambitious experimental series, DeepStore will shed new light on long-standing open questions about working memory storage, including how it is modulated by attention, inattention, and distraction, and how multiple contents are stored simultaneously. The work will shape a new theory of the neurocognitive capacity limit in working memory. We will further test novel hypotheses about how working memory interfaces with long-term memory, and how it develops over the lifespan. Finally, we will combine our innovative human neuroimaging approach with direct electrophysiological recordings in non-human primates during the same task, to disclose the fine-grained neural mechanisms of dynamic abstraction down to the single-cell level. DeepStore is anticipated to provide fundamentally new insights into the dynamic and multi-layered nature of working memory, beyond the number and precision of items it can hold.
Los chonetáceos (braquiópodos) del Devónico boliviano: bioestratigrafía y datos taxonómicos complementarios.

Como consecuencia del estudio bioestratigráfico detallado de varias secciones en la secuencia devónica del Altiplano y en la Zona Subandina de Bolivia, en este trabajo se establece, por primera vez, la distribución vertical de los representantes de la Superfamilia Chonetácea y se propone un ensayo de correlación entre la sucesión del Altiplano y la de la Zona Subandina. Las investigaciones de campo permitieron la recolección de abundante material lo cual supuso no sólo la descripción de diversas especies sino tambien la revisión de la posición taxonómica de otras. Se describen una subfamilia nueva (Notiochonetinae nov.), 1 género y 6 especies nuevas: Amosina tarabucensis nov. sp., Anoplia mariae nov. sp., Montsenetes boliviensis nov. gen. nov. sp., Pleurochonetes sorucoi nov. sp., P.? condori nov. sp., y Chonostrophia truyolsae nov. sp. Tres especies continúan provisionalmente en nomenclatura abierta: Longispina sp. C, Longispina sp. D y un chonostrófido indeterminado.
LINEAR BALL BEARING

The invention relates to a linear ball bearing comprising a guiding carriage (2) that is guided on a guide rail (1) in a longitudinally displaceable manner and is mounted on rolling bearings on longitudinal sides of the guide rail (1) by means of balls (3) that are arranged on each longitudinal side in at least two parallel rows (4, 5) running along continuous ball channels (6). Each ball (3) pertaining to one row (5) of balls is held all-round in separator pockets (8) of a common separator part (7), with an adjacent ball (3) pertaining to the other row (4) of balls. A separator part (7) comprises exactly two pockets (8) for a ball (3) from both rows (4, 5). The two ends of each separator part (7) are provided with end faces (9) which are convex in the moving direction of the balls (3), in order to be brought into contact with the end faces (9) of adjacent separator parts (7), said end faces (9) extending essentially up to the sides (10) of the separator parts.
KITCHEN APPLIANCE AND ACCESSORY ELEMENT FOR SEALING A PROTECTIVE HOOD OF A KITCHEN APPLIANCE

The invention relates to a kitchen appliance, preferably a hand-held kitchen appliance, for food processing, which has: a drive shaft which is mounted rotatably and can be operatively connected to a motor of the kitchen appliance; a working part, preferably having a blade, which is provided on the drive shaft; a protective hood which has multiple cut-outs in the circumferential direction, surrounds the working part in the circumferential direction of the rotation of the drive shaft and has an opening in the axial direction of the drive shaft; and a preferably cylindrical accessory element which can be removed from and attached to the protective hood without tools. The accessory element has an outer body with a first axial end face and a second, opposing axial end face remote from the protective hood, and the protective hood defines, in cooperation with the accessory element, a cavity which is terminated in the circumferential direction of the protective hood, for processing food. The outer body also has multiple, preferably three, more preferably six, protrusions which project radially inwards and can be operatively connected to the cut-outs in the protective hood. The invention also relates to an accessory element for sealing a protective hood of such a kitchen appliance.
The safety of sputum induction in adults with acute exacerbation of COPD

Induced sputum is a non-invasive method, and a useful tool to evaluate inflammatory cells and mediators in the airway lumen in the setting of acute exacerbation of chronic obstructive pulmonary disease (AECOPD). However, the inhalation of hypertonic saline solution to induce sputum may cause a bronchoconstrictive response, so it is important to evaluate the success and safety of sputum induction (SI).The aims of this study were to assess the safety and efficacy of SI in adults with AECOPD.Eighty-three AECOPD subjects and 26 healthy controls underwent a modified SI. The outcome measures included fall in lung function during induction and success of SI.Adults hospitalized with AECOPD had moderate to very severe airflow obstruction. SI was successful in over 80% of subjects. The percentage decrease in forced expiratory volume in 1s (FEV1 ) from baseline by the Global initiative for Chronic Obstructive Lung Disease (GOLD) category was median 1.2(interquartile range, 0.5-3.3)(GOLD II), 2.3(1.3-3.2)(GOLD III), 5.2(3.3-8.6)(GOLD IV) and 1.4(0.5-3.2)(control), respectively. A fall in FEV1 of >20% occurred in only one subject with AECOPD who was in GOLD category III. The decrease in percentage of FEV1 from baseline was greatest in the second stage of induction, and correlated with that of the final stage (r=0.589; P=0.01). The fall in FEV1 during induction increased with GOLD category (P<0.05).SI can be safely and successfully performed in patients with moderate to very severe chronic obstructive pulmonary disease who experience an exacerbation using this modified induction protocol. The early decrease in FEV1 can be used to predict the maximum fall.
The presence of head-raising and resumptive-stranding in Japanese relative clauses

Japanese relative clauses (RCs) show peculiar characteristics. For instance, while weak crossover effects reveal that relativization includes movement, the absence of island effects seems to demonstrate that relativization does not include movement. Ishii (1991) accounts for this peculiarity of Japanese RCs by his last-resort analysis; however, because of the Inclusiveness Condition (Chomsky 1995), this last-resort model is not tenable in the Minimalist Program (MP). Therefore, an improved characterization of Ishii’s last-resort analysis of relativization in Japanese is needed within the framework of the MP. In this paper, I claim that reconstruction/connectivity effects show that Japanese RCs include promotion/head-raising. I then propose that the amendment of Boeckx’s (2003) resumptive-stranding model, which includes promotion/head-raising of a relative head and pro-stranding, can offer an account of both the movement properties and non-movement properties of Japanese RCs. The proposed analysis conforms...
Structural and phonon properties of InN synthesized by ion implantation in SiO2

Abstract Ion-implantation is a powerful technique for the formation of compound semiconductor nanocrystal precipitates in a host medium. The aim is to elaborate quantum dots for device technology purposes. High dose (5.2 × 10 16  ions/cm 2 ) implantations of Indium (In) and Nitrogen (N) ions have been performed in a 206 nm thick SiO 2 layer thermally grown on silicon. The implantation energies have been chosen from 12 to 180 keV to produce 5–10 at.% profiles overlapping at a mean depth of about 100 nm. Thermal treatments between 500 °C and 900 °C for different annealing times lead to the formation of InN nanometric precipitates and to cure the oxide defects. In addition, the In 2 O 3 and metallic indium phases have been observed. Their sizes, crystalline structures and depth distributions have been studied as a function of annealing temperature using grazing incidence X-ray diffraction, transmission electron microscopy, Rutherford back scattering spectrometry and Raman spectroscopy.
Dynamic Difficulty Adjustment of Game AI by MCTS for the game Pac-Man

Dynamic Difficulty Adjustment (DDA) of Game AI aims at creating a satisfactory game experience by dynamically adjusting intelligence of game opponents. It can provide a level of challenge that is tailored to the player's personal ability. The Monte-Carlo Tree Search (MCTS) algorithm can be applied to generate intelligence of non-player characters (NPCs) in video games. And the performance of the NPCs controlled by MCTS can be adjusted by modulating the simulation time of MCTS. Hence the approach of DDA based on MCTS is proposed based on the application of MCTS. In this paper, the prey and predator game genre of Pac-Man is used as a test-bed, the process of creating DDA based on MCTS is demonstrated and the feasibility of this approach is validated. Furthermore, to increase the computational efficiency, an alternative approach of creating DDA based on knowledge from MCTS is also proposed and discussed.
Evaluation of alteration in mucogingival line location following use of subepithelial connective tissue graft

The aim of this study is to evaluate the positional changes that occur in mucogingival line following the use of subepithelial connective tissue graft (SCTG).In 19 Miller class I or II gingival recession defects, distance between mucogingival line (MGL) and cemento-enamel junction, also width of keratinized and attached gingiva, and clinical attachment level were measured. SCTG were used for covering the exposed roots. A fore mentioned parameters were repeated at 3, 6 and 12 months after surgery and alterations were measured. Paired t test was used to analyze the results.MGL had been moved in coronal direction (4.39 +/- 0.77 mm on average) during surgical approach. After 1 year, MGL shifted 2.11 +/- 0.7 mm apically. In accordance with this apical shift, a significant increase in the width of keratinized and attached gingival width (2.89 +/- 0.63 mm and 2.82 +/- 0.5 mm, respectively) was seen (P < 0.05).MGL tended to revert back to its original position following the use of SCTG, and this reversion is accompanied with an increase in the keratinized and attached gingival width.
Size-controlled ambipolar graphene nanoribbon transistors by an all-dry mask method

Abstract Conventional graphene nanoribbon (GNR) field-effect transistor (FET) fabrication involved the wet process with the separated nanoribbon formation and device fabrication. Here, we demonstrate one simple and novel non-solution method to integrate the GNR formation and the FET fabrication, where a gold film is used as mask for electrode deposition, following by using a SnO 2 nanoribbon as mask for the formation of GNR. The channel length and width can be controlled by the widths of the gold film and the SnO 2 nanoribbon, respectively. It is found that the GNR with the width up to 330 nm presents the promising ambipolar field-effect properties in air ambient, the hole and electron mobilities are respectively as high as 904 and 703 cm 2  V −1  s −1 , which benefits from the all dry process for both GNR fabrication and device fabrication.
Italo-Maltese harmonization for a good state of the environment: seafloor integrity and interaction with invasive species to preserve the functioning of marine ecosystems

HARMONY aims at  harmonising a set of monitoring and control measures between the two cross-border countries, Italy and Malta, in order to share and integrated framework of knowledge and coordinated intervention strategies on:_x000D_
1) the integrity of marine seafloor and the inhabiting species, _x000D_
2) the effects of habitat fragmentation in facilitating the diffusion of Non-Indigenous Species (NIS)._x000D_
 _x000D_
By integrating these two aspects, HARMONY will reach a better understanding of marine ecosystem functioning in a cross-border context thus resulting:_x000D_
a) integrated interventions and measures of monitoring with the aim to suggest management plans of Natura 2000 sites and habitats. _x000D_
b) set of outputs which will be promoted by HARMONY are integrated to produce a common strategy and develop common EDRR tools (Early Detection & Rapid Response), develop innovative high resolution data recording sensors, or monitoring networks based on participatory processes (e.g. citizen science) that will allow to: _x000D_
- activate control measures to reduce the likelihood of alteration due to the alien species spread and the seafloor integrity at sites of high ecological (biodiversity) and socio-economic value (Nature 2000 sites), _x000D_
- align policy actions between the two countries, _x000D_
- foster the effectiveness of generated management strategies and lastly ,_x000D_
- create a common permanent governance structure of Italo-Maltese cross-border EDRR.
Immersion of 17-Methyltestosterone Dose&Duration on Tilapia Masculinization

Thirty five Nile Tilapia (Oreochromis niloticus L. 1758) eggs or fry at the ages of 2 and 14 days post fertilization (dpf) were randomly selected and put into a 1L plastic bottle incubator. These were then immersed either in 0, 250 or 500μg/L of 17α-methyltestosterone (MT) for 6, 12, 24, 48, 72 and 96h separately. Controls were established using eggs or fry at the same age groups immersed only in ethanol (250μL/L) instead of MT at the same amount and duration. At the end of the treatment, they were washed and nursed in 10L plastic containers and 100L glass aquaria which were replenished with water according to their growth. They were fed with 40% protein pellet until 62 - 65dpf then dissected for gonadal sex determination using aceto-carmine squash method. The results showed that both the 250 and 500μg/L MT induced (P
Forecasting the recurrence rate of volcanic eruptions

Volcanic eruptions occur with a frequency that is inversely proportional to their magnitude. Datasets of natural volcanic events, currently used to determine the recurrence rate of volcanic eruptions are intrinsically biased. Combining physical modelling of processes with detailed statistical analysis has been demonstrated essential for assessing reliably the recurrence rate of natural hazards, such as floods and earthquakes. This would be the first attempt to apply a similar, integrated approach to explosive volcanic eruptions.

 The high-gain final target of FEVER is to produce a physically based statistical model able to ForEcast the recurrence rate of Volcanic Eruptions both at regional and global scale. This is the first project of this kind and consequently involves a significant risk. Because 500 million people live in proximity of volcanoes and eruptions have a significant social and economical impact, forecasting the recurrence rate of volcanic eruption remains a great challenge in Science.

 This project builds on two main directions of my research: a) Thermo-mechanical and statistical modelling targeting the identification of the main physical factors controlling the recurrence rate of volcanic eruptions. We showed that the flux of magma from depth directly controls the magnitude of the largest possible eruptions. Thus, b) we developed a novel method to determine such magma fluxes. These two lines of research combine perfectly in FEVER and will be integrated to answer questions such as: What is the probability of an eruption similar to the Tambora 1815 to occur in the next 100 years on Earth or in Europe? What is the largest physically possible eruption that can occur in Europe?
 
 The high-gain target of FEVER is to mitigate the impact of volcanic eruptions on our society, by producing research of interest for governmental agencies dealing with location of strategic infrastructures, and for businesses such as aviation.
Illuminating the 'grey zone': addressing complex complicity in human rights violations

The grey zone of bystanders, collaborators and beneficiaries of violence escapes the scope of main Transitional Justice (TJ) institutions and poses tough questions for scholars and architects of post-conflict societies. This interdisciplinary project shifts the focus of academic and political debates by pursuing three objectives: conceptually, it departs from the dominant victim-perpetrator paradigm and theorises the many faces in the grey zone by analysing the interplay between structure and agency; normatively, it argues that no account of TJ is complete without engaging the grey zone; empirically, it tests if, in tackling the grey zone, cinematographic and literary representations  can supplement typical TJ mechanisms (trials, truth commissions, lustration). Four cases are analysed: authoritarianism plus military occupation (Vichy France), apartheid (South Africa), totalitarianism (Romania 1945–1989) and military dictatorship (Argentina 1976–1983). The cases provide a variety of contexts of complicity and feature the most frequently used TJ mechanisms. They serve to a) examine the relationship between the official story emerging from state-orchestrated TJ mechanisms and artistic narratives of complicity; b) contextually distinguish disclosive from obscuring artistic representations of the grey zone; c) explore the contribution of these representations to TJ efforts by studying their effect on public debates about—and institutional responses to—the past. Working at the frontiers between political science, philosophy, history, law, literature and cinema, this pioneering project has critical and institutional impact. Critically, it discloses the limits of current TJ theory and practice by emphasising the negative political effects of ignoring general complicity in violence. Institutionally, it seeks to enrich the toolkit of scholars and practitioners by pointing to the potential use of cinema and literature in civic education aimed at deterrence and reconciliation.