SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Guiding Mediterranean MPAs through the climate change era: Building resilience and adaptation

The Mediterranean Sea climate will undergo rapid changes over the next decades.  Direct evidence of climate change (CC) is already being observed at Mediterranean coast, including marine protected areas (MPAs). The need for building resilience in both social and ecological aspects of MPAs, through taking on adaptive management thus becomes an essential element for mitigating against and adjusting to the rapid changes to maintain and protect healthy ecosystems. However, CC is not explicit incorporated in most management plans and information to assist MPA decision making is both limited and fragmented.The goals of the MPA-Adapt are to develop collaborative and site-specific adaptation plans for the MPAs that enhance resilience to CC impacts. This will be achieved by building capacity for effective management, assessing risks- and exploring potential actions and priorities needed to ensure the adaptability and the resilience of biodiversity and the local communities. It also aims to incorporate CC vulnerability assessments and nature-based adaptation planning into their existing management framework, and provide guidance to MPA managers and local stakeholders to implement and test climate-change approaches. This project is a first of its kind for the marine and coastal Mediterranean environment and will also foster networks by improving the dialogue and coordination between MPA managers and scientists in order to create the first line of Mediterranean MPA sentinel sites.
Towards advanced bicmos nanotechnology platforms for rf and thz  applications

The TARANTO project targets to break  the technological barriers to the development of the next BiCMOS technology platforms, allowing the improvement of the performance of the HBT (Heterojunction Bipolar Transistors) with a much higher level of integration. This new generation of transistors HBT will be a key factor to meet the needs of high-speed communications systems and high data rate required for the integration of heterogeneous intelligent systems as well as for intelligent mobility systems that will be used in future fully automated transport systems. The main objectives of this project will be to develop transistors HBT  offering high maximum frequency (Fmax: 600GHz) built to very high density CMOS processes: 130 / 90nm for IFX, 55 / 28nm to ST, while IHP will work on the project to achieve maximum frequencies of 700GHz remaining compatible with IFX and ST BiCMOS processes.

The project consortium gathers the main European players in the value chain for these applications at  very high frequencies, from laboratories to industrial users, thus ensuring the highest scientific level and the ability to validate the work carried out on appropriate demonstrators.
e-bike

The E-bike project aims at guaranteeing the conservation and promotion of the natural and cultural heritage of the area through the development of a model of cross-border governance of the tourism offer and through the aggregation of a cluster of services for the tourism in the interested areas, of which the e-bike represents the central element. In this way we intend to diversify and de-season the offer, currently concentrated in the winter period, also supporting its expansion through international promotion and marketing. Guidelines will be produced for the common definition of signage, the identification of a potential market and the methods for creating business networks. The contents developed by the project will be used for training activities for tourist guides and maintenance personnel.
ROBERTO GENNARO

THE COMPANY CONSISTS OF A UNIPERSONAL CIVIL ENGINEERING PROFESSIONAL FIRM, WHICH OPERATES SINCE 2005 IN THE TERRITORY OF LIGURIA, PIEDMONT AND UPPER TUSCANY MAINLY IN THE FIELD OF TECHNICAL-LEGAL ADVICE RELATING TO JUDICIAL AND EXTRAJUDICIAL LITIGATION (ABOUT 80 % OF THE ANNUAL TURNOVER). THE HOLDER (PLURILAUREATE) CURRENTLY CARRIES OUT ACTIVITIES OF C.T.U. AND EXPERT FOR THE COURT OF APPEAL OF GENOA AND ALEXANDRIA WITH SPECIALISATION IN BUILDING SECTORS (ARCHITECTURAL AND STRUCTURAL LEVEL), URBAN PLANNING, PROCUREMENT, CIVIL AND RURAL ESTIMATION, DIAGNOSIS AND ENERGY SAVING OF BUILDINGS, AS WELL AS HAVING BEEN ONE OF THE FIRST ENERGY CERTIFIERS OF THE LIGURIA REGION SINCE THE TIME OF ESTABLISHMENT OF THE RELEVANT REGIONAL REGISTER. SINCE 2017, THE HOLDER HAS BEEN CERTIFIED FIRST LEVEL CERT’ING IN FORENSIC ENGINEERING. AT THE DEADLINE (APRIL 2020), THE ACHIEVEMENT OF SECOND LEVEL CERT’ING CERTIFICATION IN F FIELD IS BEING FINALISED
Effect of the Sn dopant on the crystallization of amorphous Ge 2 Sb 2 Te 5 films induced by an excimer laser

Abstract In this paper, the influence of Sn doping (0%, 8%, and 14%) on the crystallization of Ge 2 Sb 2 Te 5 (GST) was studied with the aid of an ultraviolet laser. It was found that the addition of Sn element not only expanded the lattice parameter but also decreased the crystallization temperature and activation energy as compared to the GST. As compared to the Ge 2 Sb 2 Te 5 , a more complete crystallization of the Sn doping Ge 2 Sb 2 Te 5 is mainly due to the lower binding energy of Sn–Te (359.8 kJ/mol), which could be more easily taken part in the bond breakage and formation than Ge–Te (456 kJ/mol) in such a short time as 30 ns. The equiaxial grains were obtained for the Sn 8 Ge 15 Sb 23 Te 54 films when crystallization was induced by the laser fluence of 20 mJ/cm 2 but the grains elongated when the laser fluence was increased to 60 mJ/cm 2 . The reason may be the incorporation of Sn elements changed the crystal nucleation mode.
Anthropometric and Physical Profiles of English Academy Rugby Union Players

The purpose of this study was to evaluate the anthropometric and physical characteristics of English regional academy rugby union players by age category (under 16s, under 18s and under 21s). Data were collected on 67 academy players at the beginning of the preseason period and comprised anthropometric (height, body mass, and sum of 8 skinfolds) and physical (5-, 10-, 20-, and 40-m sprint, acceleration, velocity, and momentum; agility 505; vertical jump; Yo-Yo intermittent recovery test level 1; 30-15 intermittent fitness test; absolute and relative 3 repetition maximum front squat, split squat, bench press, prone row, and chin; and isometric mid-thigh pull). One-way analysis of variance demonstrated significant increases across the 3 age categories (p ≤ 0.05) for height (e.g., 16s = 178.8 ± 7.1; 18s = 183.5 ± 7.2; 21s = 186.7 ± 6.61 cm), body mass (e.g., 16s = 79.4 ± 12.8; 18s = 88.3 ± 11.9; 21s = 98.3 ± 10.4 kg), countermovement jump height and peak power, sprint momentum, velocity, and acceleration; absolute, relative, and isometric (e.g., 16s = 2,157.9 ± 309.9; 18s = 2,561.3 ± 339.4; 21s = 3,104.5 ± 354.0 N) strength. Momentum, maximal speed, and the ability to maintain acceleration were all discriminating factors between age categories, suggesting that these variables may be more important to monitor rather than sprint times. These findings highlight that anthropometric and physical characteristics develop across age categories and provide comparative data for English Academy Rugby Union players.
Algorithms in algebra and topology

Group theory is the study of symmetry in mathematical objects, such as rotations of geometric shapes.
Groups help us understand the underlying structure of mathematical objects by revealing their symmetries.
To understand groups we need an efficient way to describe them. Some groups admit a finite presentation;
a finite set of building blocks, along with a finite collection of rules on when we can substitute one set
of blocks for another. These descriptions are convenient. However, results in algebra and logic show
that such descriptions are not always suitable to work with, as certain problems (e.g., the word problem,
of deciding if two distinct collections of blocks represent the same group element) are incomputable; no
computer can be built to always answer this. We can embed incomputable problems from groups into
geometry, to show that the homeomorphism problem, of recognising if two geometric shapes are equivalent
under smooth deformation, is incomputable in all dimensions above three. Thus we can't computationally
classify geometric shapes in higher dimensions; we can't identify the unique distinguishing features of
each shape. The study of generic computability (problems which can be computed most of the time) is
a useful area in mathematics. Conversely, showing a problem can't be computed most of the time gives
rise to applications in cryptography: generically incomputable problems are an excellent tool in the theory
behind cryptosystems. This proposal will deal with incomputable and generically incomputable problems.
We will investigate certain problems in group theory to determine if they are computable, or generically
computable, or neither. We will apply these results to particular classess of higher-dimensional geometric
objects, identifying whether certain problems relating to them are computable or not. The project will be
carried out at the University of Cambridge, under the supervision of Dr. Henry Wilton.
Assessment of reserve: translational evaluation of medical images and statistics - prediction models for outcomes of brain health

Stroke and cognitive decline are among the leading contributors to disease burden and long-term disability worldwide. Despite their prevalence, the contributing disease processes are not fully understood. This is in part due to the lack of (early) prediction models and ways to characterize protective mechanisms, which can help to distinguish between patients and healthy individuals before symptoms manifest. Such prediction models can facilitate prevention strategies for adverse cognitive and functional outcomes, thereby enriching patients’ life quality and reduce the economic burden on society. Advanced neuroimaging techniques, such as MRI, have provided additional insight into the underlying disease biology. One major challenge when using neuroimaging techniques lies in the fact that large amounts of data are required to account for variations in clinical presentation and assessment, necessitating the use of dedicated pipelines for extracting phenotypes. However, most pipelines are developed in research settings and tend to fail when applied to real-life clinical cohorts, leading to a subpar use of rich, available patient datasets.

Here, a fully-automated, translational pipeline for extracting MRI phenotypes from data acquired in clinical and research settings is developed with a particular focus on outlining white matter hyperintensities (WMH). WMH are a common phenotype in aging and across diseases; however, group differences are poorly understood. This makes WMH a prime candidate for extracting additional information, which can be used for outcome prediction. The proposed prediction models utilize newly extracted characteristics, clinical/demographic information and a latent variable construct to predict general cognitive decline and outcome after stroke. In particular, the proposed latent variable has shown promise in acting as a surrogate measure for protective mechanisms in stroke patients, where its biological meaning is assessed as part of this project.
The in-situ solid-state NMR spectroscopy investigation of alcoholic lactose suspensions

The polymorphic forms of lactose in alcoholic suspensions have been determined by (13)C CP-MAS NMR spectroscopy, employing hand-made glass inserts. Suspensions of alpha lactose monohydrate (Lalpha.H(2)O) with particle size between 2 and 200mum were prepared by 24h reflux or by storage for 28d in anhydrous ethanol without agitation. These suspensions were compared to an ethanolic sub-micron lactose suspension provided by a 3M Health Care (Loughborough). The (13)C CP-MAS NMR spectra indicated that Lalpha.H(2)O dehydrated to stable anhydrous alpha lactose polymorph (Lalpha(S)) whilst suspended in ethanol. In addition, strong ethanol (13)C resonances were observed for some samples, indicating a liquid-solid interaction between the ethanol and lactose surface. Replacement of ethanol with anhydrous methanol, n-butanol and 3-methylbutan-2-ol implied that the solvent mediated dehydration of Lalpha.H(2)O to Lalpha(S) occurs as a result of sterically controlled interactions.
APPARATUS AND METHODS FOR INSERTING FACET SCREWS

An apparatus includes a first shaft (1100), a second shaft (1200), and a locking mechanism (1300). The first shaft may have a threaded portion (1126) and has an engagement portion (1110). The engagement portion of the first shaft is configured to engage a nut (1610). The second shaft may have a threaded portion (1232) and has an engagement portion" (1210). The engagement portion of the second shaft is configured to engage a screw (1650). At least a portion of the second shaft is disposed within the first shaft such that the threaded portion of the first shaft is engaged with the threaded portion of the second shaft. The locking mechanism is configured to selectively allow rotation of the second shaft relative to the first shaft.
Expert opinion 2011 on the use of new anti-resorptive agents in the prevention of skeletal-related events in metastatic bone disease

Bisphosphonates have been a mainstay in the treatment of cancer-related bone disease and have greatly reduced the risk of skeletal complications. More recently, clinical studies suggested additional benefits of denosumab over zoledronic acid in the prevention of skeletal related events. Similar adverse event profiles have been reported for bisphosphonates and denosumab, with infrequent occurrences of osteonecrosis of the jaw with both agents, higher incidence of renal deterioration with zoledronic acid, and higher incidence of hypocalcaemia with denosumab. Based on current evidence, the American Society of Clinical Oncology (ASCO) and National Comprehensive Cancer Network (NCCN) guidelines do not recommend one drug class over the other in patients with metastatic bone disease. Denosumab, however, may present advantages over bisphosphonates in patients suffering from chronic renal insufficiency. Further research and growing clinical experience will refine the evidence based on which decisions in daily clinical practice can be taken.
REMOVING SCALE FROM A WELLBORE

Supercritical carbon dioxide is directed into a wellbore to a specified depth. The supercritical carbon dioxide is directed at an inner surface of the wellbore at the specified depth. Scale is removed from the wall of the wellbore with the supercritical carbon dioxide.
B05: RESULTS FROM A META-ANALYSIS OF CILTACABTAGENE AUTOLEUCEL COMPARED TO PHYSICIAN’S CHOICE OF TREATMENT IN PATIENTS WITH RELAPSED OR REFRACTORY MULTIPLE MYELOMA

Introduction: The CARTITUDE-1 trial (NCT03548207) is evaluating ciltacabtagene autoleucel (cilta-cel), a novel chimeric antigen receptor T-cell therapy, in patients with relapsed/refractory multiple myeloma (RRMM) who are triple-class exposed to immunomodulatory drugs, proteasome inhibitors, and an anti-CD38 monoclonal antibody. Indirect treatment comparisons (ITCs) have been previously conducted between cilta-cel and physician’s choice of treatment (PCT) as no clear standard of care exists for patients with triple-class exposed RRMM and no direct head-to-head trials were performed to evaluate cilta-cel and other relevant treatments. Objective: To perform meta-analyses to derive single summary effect estimates for overall survival (OS) and progression-free survival (PFS) using pooled ITCs that evaluated cilta-cel versus PCT in patients with triple-class exposed RRMM. Methods: ITCs comparing the effectiveness of cilta-cel versus PCT on OS and PFS were included in this analysis. The data cut-off date for CARTITUDE-1 was February 2021, and data for PCT were based on the following sources: (i) Flatiron, a largely US community-based MM registry; (ii) long-term follow-up data from POLLUX (NCT02076009), CASTOR (NCT02136134), and EQUULEUS (NCT01998971), three global RRMM daratumumab randomized clinical trials; (iii) MAMMOTH, a retrospective study based in the US; and (iv) a representative German patient registry maintained by OncologyInformationService. The PCT group for each ITC comprised patients who fulfilled key eligibility criteria for the CARTITUDE-1 trial and was made comparable to CARTITUDE-1 using inverse probability of treatment weighting, resulting in ITCs that were appropriate for meta-analysis. The meta-analysis used a robust variance estimator to account for the use of CARTITUDE-1 in each pairwise ITC. The main meta-analyses included all patients treated with cilta-cel in CARTITUDE-1 compared with PCT. Sensitivity analyses considered ITC effect estimates based on all patients enrolled in CARTITUDE-1. Hazard ratios (HRs) and corresponding 95% confidence intervals (CIs) are reported for pooled summary effect estimates. Results: Based on available data, the main meta-analyses included four ITCs for OS and three ITCs for PFS. Significant improvement in OS (HR: 0.21, 95% CI: 0.13–0.34) and PFS (HR: 0.20, 95% CI: 0.07–0.63) was observed with cilta-cel versus PCT (Figure). Results of the main meta-analyses were confirmed with sensitivity analyses that included all enrolled patients. Conclusions: Cilta-cel demonstrated a significant OS and PFS advantage versus PCT in the meta-analyses, highlighting its potential as an effective treatment in patients with triple-class exposed RRMM.
The Birth of the Monsoon Winds: On the Existence and Understanding of Hippalus, and the ‘Discovery’ of the Apogeous Trade Winds

AbstractA review is presented of the surviving primary evidence of Hippalus as the discoverer of the trade route that allowed sailing vessels to run before the wind from the mouth of the Arabian Sea to the southern ports of India during the summer, and return with the winter monsoon during the 1st century ce. His stature as a skilful navigator is associated with the riches this discovery brought to Rome and the western world at the time, but questions are raised about the prestige he has been accorded in the modern historiography. Specifically, questions are posed about the explorer’s absence from texts in which he might be expected to appear, and his fumbled inclusion in those texts that do give him mention. The conclusion is that there is scant record of Hippalus’ actual existence, and the foundation of his continued recognition as a great discoverer is therefore questionable. However, despite the patchy historical record of the man, the surviving myth has real value in interpreting and understanding th...
PROTEASES FROM GRAM POSITIVE ORGANISMS

The present invention relates to the identification of a novel metalloprotease in gram positive microorganisms. The present invention provides the nucleic acid and amino acid sequences for the metalloprotease. The present invention also provides host cells having a mutation or deletion of part or all of the gene encoding the metalloprotease. The present invention provides host cells which further comprises a nucleic acid encoding desired heterologous proteins such as enzymes. The present invention also provides cleaning compositions, animal feeds and compositions used to treat a textile that include the metalloprotease of the present invention.
European Cultural Routes - Transfer Experiences, Share Solutions

CERTESS project aims at setting up a common methodological framework on how to develop, manage and enhance European Cultural Routes (ECRs), by utilising reference development and governance instruments targeted to foster sustainable cultural tourism.
Most of ECRs identified to date, and regions intersected by them, lack in fact comprehensive methodologies, governance instruments, innovative ideas to implement effective strategies at regional level, with a range of local initiatives that are casually scattered along the route and its associated territory, have no critical mass, do not involve a systematic approach and have poor coherence.
Best Practices (BPs) tackle initiatives on ECRs, from local micro-level to higher decision making, to (a) identify, structure & add value to local cultural & natural heritage assets, (b) develop & adopt well-suited governance tools, (c) promote local enterprises & products along the routes by adopting innovative immaterial services including ITC.
CERTESS partnership includes 11 regional actors from 10 countries (including 4 New Member Countries & 2 islands) all active in ECR development under the coordinating knowledge-repository role of the European Institute of Cultural Routes as Lead Partner.
Project activities consist of:
A) Transfer of experience (identify, document, check on site, select BPs | design BP transfer to suit needs & contexts of partner regions | arrange for tutoring activities by BP transfer to recipient regions).
B) Policy development (identify and adapt governance instruments at regional level involving local stakeholders | draw multi-sectoral  governance instruments (policy)  within a local Route Implementation Plan to be officially acknowledged as a regional strategic programme to promote a specific ECR.
Each Plan shall include: ECR development policy; adoption of reference BPs; support to public-private initiatives; dissemination to other ECR regions; action financing; design of route governance.
Sound project management is secured by adopting quality management tools and a multi-faceted communication plan.  CERTESS project results shall be reflected in a common knowledge-base platform to ensure project durability and to act as ECRs reference at regional level with regard to policies and innovative solutions for cultural tourism, to facilitate ECRs interlinking at all levels among regions and to effectively contribute to the image of “Europe first cultural tourism destination in the world”.
Project partner regions will have the possibility to integrate NECSTOUR network of regions and to cooperate on a long term basis by exchanging experiences with other EU regions and by benefitting of the results already achieved or being achieved in other Interreg projects.
Other EU institutions involved in ECRs will attend project activities as a pool of observers to give their feedback to the project and to reflect its results afterwards at EU level.