SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
AW00179 potentiates TRAIL-mediated death of human lung cancer H1299 cells through ROS-JNK-c-Jun-mediated up-regulation of DR5 and down-regulation of anti-apoptotic molecules

Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) triggers apoptosis in tumor cells, but when used alone, it is not effective at treating TRAIL-resistant tumors. This resistance is challenging for TRAIL-based anti-cancer therapies. In this study, we found that 1-(4-trifluoromethoxy-phenyl)-3-[4-(5-trifluoromethyl-2,5-dihydro-pyrazol-1-yl)-phenyl]-urea (AW00179) sensitized human lung cancer H1299 cells to TRAIL-mediated apoptosis. Even in the absence of TRAIL, AW00179 strongly induced DR5 expression and decreased the expression of anti-apoptotic proteins, suggesting that the sensitizing effect of AW00179 on TRAIL-mediated apoptosis is due to increased levels of DR5 protein and decreased anti-apoptotic molecules. AW00179 also induced the activation of c-Jun and ERK; however, a pharmacologic inhibition study revealed that JNK-c-Jun signaling is involved in the induction of DR5 expression. In addition, reactive oxygen species (ROS) appear to be involved in AW00179 activity. In conclusion, AW00179 has the potential to sensitize H1299 cells to TRAIL-mediated apoptosis through two distinct mechanisms: ROS-JNK-c-Jun-mediated up-regulation of DR5, and down-regulation of anti-apoptotic molecules.
Game Changing Computational Engineering Technology

During the last two decades, giant strides have been achieved in many aspects of Computational Engineering. Higher-fidelity mathematical models, better approximation methods, and faster algorithms have been developed for many time-dependent applications. SIMD, SPMD, MIMD, coarse-grain, and fine-grain parallel processors have come and gone. Linux clusters are now ubiquitous, cores have replaced CEs, and GPUs have shattered computing speed barriers. Most importantly, the potential of high-fidelity physics-based simulations for providing deeper understanding of complex engineering systems and enhancing system performance has been recognized in almost every field of engineering. Yet, in many engineering applications, high-fidelity time-dependent numerical simulations are not performed as often as needed, or are more often performed in special circumstances than routinely. The reason is very simple: these simulations remain too computationally intensive for time-critical operations such as design, design optimization, and active control. Consequently, the impact of computational sciences on such operations has yet to materialize. Petascale or exascale computing alone is unlikely to make this happen. Achieving this objective demands instead a game-changing computational technology that bridges both ends of the computing spectrum. This talk will attempt to make the case for this pressing need and outline a candidate computational technology for filling it that is based on model reduction, machine learning concepts, trained data bases, and rigorous interpolation methods. It will also illustrate it with preliminary results obtained from its application to the support of the flutter flight testing of a fighter aircraft and the aerodynamic optimization of Formula 1 car.
The Canadian Seasonal to Interannual Prediction System. Part I: Models and Initialization

Abstract The Canadian Seasonal to Interannual Prediction System (CanSIPS) became operational at Environment Canada's Canadian Meteorological Centre (CMC) in December 2011, replacing CMC's previous two-tier system. CanSIPS is a two-model forecasting system that combines ensemble forecasts from the Canadian Centre for Climate Modeling and Analysis (CCCma) Coupled Climate Model, versions 3 and 4 (CanCM3 and CanCM4, respectively). Mean climate as well as climate trends and variability in these models are evaluated in freely running historical simulations. Initial conditions for CanSIPS forecasts are obtained from an ensemble of coupled assimilation runs. These runs assimilate gridded atmospheric analyses by means of a procedure that resembles the incremental analysis update technique, but introduces only a fraction of the analysis increment in order that differences between ensemble members reflect the magnitude of observational uncertainties. The land surface is initialized through its response to the assimilative meteorology, whereas sea ice concentration and sea surface temperature are relaxed toward gridded observational values. The subsurface ocean is initialized through surface forcing provided by the assimilation run, together with an offline variational assimilation of gridded observational temperatures followed by an adjustment of the salinity field to preserve static stability. The performance of CanSIPS historical forecasts initialized every month over the period 1981–2010 is documented in a companion paper. The CanCM4 model and the initialization procedures developed for CanSIPS have been employed as well for decadal forecasts, including those contributing to phase 5 of the Coupled Model Intercomparison Project.
A realizability approach to complexity theory

Complexity theory concerns fundamental questions on the mathematics of computer science about the amount of resources needed to run programs or solve problems. The ReACT project will build on recent work in realizability models for linear logic to provide new characterizations of existing complexity classes. The end goal is to enable researchers to attack long-standing open problems in complexity theory by using mathematical techniques, tools and invariants from operators algebras and dynamical systems.
The ""complexity-through-realizability"" techniques developed by the ReACT project will provide a unified framework for studying many computational paradigms and their associated computational complexity theory grounded on well-studied mathematical concepts. This will allow for comparison of complexity classes defined from different computational paradigms (e.g. sequential and quantum computation), as well as establish a theory of complexity for computational paradigms lacking such (e.g. concurrent processes).
The ""complexity-through-realizability"" approach stems from established logical-based approaches of complexity theory and inherits their strengths. It furthermore improves crucially over them as it builds upon state-of-the-art theoretical results on realizability models for linear logic using well-studied mathematical concepts from operators algebras and dynamical systems. As a consequence, it opens the way to the use against the open problems of the discipline the many techniques, tools and invariants that were developed in these mathematical disciplines.
The ReACT project has two objectives. The first objective aims at establishing this new approach to complexity as an emerging and promising field of study which generalizes and extends previous techniques. The second objective is to investigate investigating how the mathematical methods and techniques derived from of our approach can be used to attack long-standing open problems in complexity theory.
An Investigation into Use of Different Soft Artificial Intelligence Techniques in Mechanical Engineering Domain

In the present era, of globalization and automation, artificial intelligence (AI) has come out as a better implement to solve many problems that require decision making. In this work, it has been tried to amalgamate the research work done related to application of soft computing techniques particularly in the area of mechanical engineering. A lot of researches have being carried out in this domain because it has been a pool of infinite scope for innovative works. This paper gives a quick view of the different applications of AI techniques, such as neural networks, fuzzy logic, neurofuzzy (NF), simulated annealing (SA), genetic algorithm (GA), genetic programming (GP), and data mining (DM), and provides a conscious view in the different paradigms of mechanical engineering where the soft computing techniques are separately used and even in combination with one another to perform certain tasks which if performed by human becomes a dreary task. Several applications of soft computing have been proposed in the literature to solve the problems related with complicated mechanical systems. It is felt that a review of the application in various mechanical areas would help to compare their main features and their relative advantages or limitations to allow choose the most suitable technique for a particular application and also throw light on aspects that needs further attention.
THREE DIMENSIONAL DISPLAY

A three dimensional display comprises (a) a plurality of switchable screens (2a-e) arranged one behind the other, each screen being independently switchable between a strongly scattering and substantially transparent state; (b) projection means (3) for projecting a sequence of images, each image in the sequence corresponding to one of the switchable screens and forming part of an overall three-dimensional image; and (c) synchronized switching means (4) for switching each switchable screen synchronously with the projection of the sequence of images by the projection means, such that a particular switchable screen is in its strongly scattering state when image corresponding thereto is being projected and is in its substantially transparent state at least when the image corresponding to another screen is being projected and the particular screen is positioned between that another screen and either the projector or the viewer.
Quantifying Geographic Variation in the Climatic Drivers of Midcontinent Wetlands with a Spatially Varying Coefficient Model

The wetlands in the Prairie Pothole Region and in the Great Plains are notorious for their sensitivity to weather variability. These wetlands have been the focus of considerable attention because of their ecological importance and because of the expected impact of climate change. Few models in the literature, however, take into account spatial variation in the importance of wetland drivers. This is surprising given the importance spatial heterogeneity in geomorphology and climatic conditions have in the region. In this paper, I use spatially-varying coefficients to assess the variation in ecological drivers in a number of ponds observed over a 50-year period (1961-2012). I included the number of ponds observed the year before on a log scale, the log of total precipitation, and mean maximum temperature during the four previous seasons as explanatory variables. I also included a temporal component to capture change in the number of ponds due to anthropogenic disturbance. Overall, fall and spring precipitation were most important in pond abundance in the west, whereas winter and summer precipitation were the most important drivers in the east. The ponds in the east of the survey area were also more dependent on pond abundance during the previous year than those in the west. Spring temperature during the previous season influenced pond abundance; while the temperature during the other seasons had a limited effect. The ponds in the southwestern part of the survey area have been increasing independently of climatic conditions, whereas the ponds in the northeast have been steadily declining. My results underline the importance of accounting the spatial heterogeneity in environmental drivers, when working at large spatial scales. In light of my results, I also argue that assessing the impacts of climate change on wetland abundance in the spring, without more accurate climatic forecasting, will be difficult.
Textiles Abstandsgewirke mit Massageeffekt

Textiles Abstandsgewirke, dadurch gekennzeichnet, dass ein erster Flächenbereich (2) derart abgestickt ist, dass ein zweiter Flächenbereich (3) als wenigstens ein elastischer Noppen ausgebildet ist.
Review of studies on structural performance of recycled aggregate concrete in China

This paper presents a review of the studies on the structural performance of recycled aggregate concrete (RAC) elements and structures in the past 10 years in China. The flexural and shear behaviour of RAC beams, the compression performance of RAC columns as well as the flexural performance of RAC slabs are overviewed and summarized. The seismic responses of beam-column joints, shear walls as well as frames made of RAC are also covered. The experimental observations indicate that the structural performance of RAC elements and structures is somewhat similar to that of natural aggregate concrete (NAC) members. A brief introduction to the application of RAC in sustainable buildings in China is also presented.
TANH AND SIGMOID FUNCTION EXECUTION

Examples described herein relate to instructions to request performance of tanh and sigmoid instructions. For example, a compiler can generate native tanh instructions to perform tanh. In some examples, a tanh function can be compiled into instructions that include an instruction to perform either tanh(input) or tanh(input)/input depending on a value of the input to generate an intermediate output; an instruction to cause a performance of generation of scale factor based on the input; and an instruction to cause performance of a multiplication operation on the intermediate result with the scale factor. For example, a sigmoid function can be compiled to cause a math pipeline to perform a range check and performs operations based on a range.
Precursor information analysis on acoustic emission of coal with different outburst proneness

To master the precursor information of burst coal bursting failure is the bottleneck problem to scientifically forecast rock burst,and the precursor information study on acoustic emission of coal with different outburst proneness under stress loading is one of the important ways for rock burst forecasting. The research results presented in this paper show that,as the level of coal's outburst proneness increasing,the counts of coal vibration and energy of acoustic emission were concentrated at high stress region,with the time proportion of the elastic stage increasing while time proportion of plastic stage decreasing. The width of the main frequency channel changed little,tending to a concentration. The strength of the main frequency channel increased with varying degrees during the elastic stage,plastic stage and breaking stage,the growth of the strength of frequency increasing as the coal's outburst proneness becoming larger. The stress increased as the b-value decreasing,tending to close to breaking strength of the coal.
Numerical investigation of unsteady wave phenomena for transonic airfoil flow

Abstract Transonic flow over airfoils at high Reynolds numbers shows a high number of unsteady phenomena such as local separation regions, shock–boundary layer interaction, boundary layer transition and turbulence. Furthermore, the phenomenon of upstream moving pressure waves is observed experimentally as well as numerically under certain conditions. Generally, it is not possible to simulate correctly all transonic flow phenomena in a numerical simulation as they are of different length and time scales. However, the use of high-fidelity numerical methods and a high spatial resolution increases the range of resolved scales. This paper focuses on the numerical investigation of self-induced, unsteady pressure waves propagating over an airfoil. Weak pressure waves that are generated in the vicinity of the trailing edge propagate upstream and induce a periodic shock wave formation and motion. Although the observed phenomenon is similar to buffet, it is not separation driven and the unsteady forces are smaller. The main part of the paper is related to the comparison between experimental and numerical results, validating the used numerical method and justifying its use for the simulation of unsteady, weak pressure waves in transonic flows. Besides, a deeper insight of the complex physical mechanism leading to the observed pressure wave generation and its interaction with other flow phenomena will be provided.
La traducción de una ciudad: copias de Suaquem en la cartografía manuscrita portuguesa del Mar Rojo

&#x0D; Los análisis presentados en este artículo forman parte de un proyecto de investigación que pretende comprender la construcción del conocimiento geográfico europeo en la época moderna a partir de la cartografía manuscrita portuguesa y sus copias, centrándose en los contactos entre los océanos Atlántico e Índico. El objetivo es explorar la relevancia metodológica de considerar el proceso de copia de mapas, que contienen diferencias respecto del original, como análogo al proceso de traducción. El objeto de análisis son copias de mapas recogidos en el atlas anónimo fechado entre 1633-1650, Livro das Plantas, das Fortalezas, ciudades e povoações do Estado da Índia Oriental. Entre los mapas que sirven de matrices se encuentran los Roteiros de D. João de Castro. En conclusión, se propone que las distorsiones y corrupciones de los copistas, a la vez productores y consumidores de mapas, sean entendidas como formas de interpretar y asignar significado a descripciones de espacios, en forma de textos o imágenes.&#x0D;
Collaborative research fellowships for a responsive and innovative europe

The CAROLINE Fellowship Programme proposed by the Irish Research Council (IRC) will provide a unique opportunity for researchers to further develop their skills, competencies and experience through inter-sectoral collaboration with NGOs and International Organisations (IO). Proposals will be invited from all disciplines that speak to the overarching theme of global sustainable development as set out under the United Nations 2030 Agenda for shared economic prosperity, social development, and environmental protection. CAROLINE will fund 50 experienced researchers across two modes; International Fellowships (three-year) and Irish Fellowships (two-year). The IRC, a national agency, funds excellent research across all disciplines. Unique aspects of CAROLINE include the European and global resonance of the overarching research theme, the inclusion of NGO and IO partners with the host research performing organisations, flexibility in secondments, comprehensive approaches to equal opportunities and gender aspects, and dedicated core training and career support activities. Research outcomes and activities of the CAROLINE Fellows will benefit Europe, given the significance of the theme to Europe 2020, e.g. in employment, climate change and energy, education, and poverty reduction. CAROLINE will deliver experienced researchers with enhanced skills in inter-sectoral and interdisciplinary research and better access to a wider set of future career opportunities. The IRC has built an impressive array of support for this proposal from stakeholders in Ireland, Europe and internationally, including research performing-organisations, NGOs, IOs and other partners.
An Examination of Women Experiencing Obstetric Complications Requiring Emergency Care: Perceptions and Sociocultural Consequences of Caesarean Sections in Bangladesh

Little is known about the physical and socioeconomic postpartum consequences of women who experience obstetric complications and require emergency obstetric care (EmOC), particularly in resource-poor countries such as Bangladesh where historically there has been a strong cultural preference for births at home. Recent increases in the use of skilled birth attendants show socioeconomic disparities in access to emergency obstetric services, highlighting the need to examine birthing preparation and perceptions of EmOC, including caesarean sections. Twenty women who delivered at a hospital and were identified by physicians as having severe obstetric complications during delivery or immediately thereafter were selected to participate in this qualitative study. Purposive sampling was used for selecting the women. The study was carried out in Matlab, Bangladesh, during March 2008-August 2009. Data-collection methods included in-depth interviews with women and, whenever possible, their family members. The results showed that the women were poorly informed before delivery about pregnancy-related complications and medical indications for emergency care. Barriers to care-seeking at emergency obstetric facilities and acceptance of lifesaving care were related to apprehensions about the physical consequences and social stigma, resulting from hospital procedures and financial concerns. The respondents held many misconceptions about caesarean sections and distrust regarding the reason for recommending the procedure by the healthcare providers. Women who had caesarean sections incurred high costs that led to economic burdens on family members, and the blame was attributed to the woman. The postpartum health consequences reported by the women were generally left untreated. The data underscore the importance of educating women and their families about pregnancy-related complications and preparing families for the possibility of caesarean section. At the same time, the health systems need to be strengthened to ensure that all women in clinical need of lifesaving obstetric surgery access quality EmOC services rapidly and, once in a facility, can obtain a caesarean section promptly, if needed. While greater access to surgical interventions may be lifesaving, policy-makers need to institute mechanisms to discourage the over-medicalization of childbirth in a context where the use of caesarean section is rapidly rising.
DEVICE FOR SEALING A PLASTIC CONTAINER PREFORM TO A BLOW MOULDING NOZZLE, AND CONTAINER BLOW MOULDING MACHINE PROVIDED THEREWITH

A machine for blow moulding or stretch-blow moulding a preform (5) in a mould (6), wherein a seal (20) is provided between the preform (5) and the blow moulding nozzle (1). Said seal is mounted on the nozzle (1) and can be placed in two positions, i.e. a first position in which it is prevented from contacting the preform during the insertion of the nozzle into the preform, and a second position in which it forms the seal therebetween. Members (18, 21, 26, 27) are provided for moving the seal from the first to the second positions once the nozzle has been fully positioned within the preform. A machine provided with such a device for producing containers by blow moulding or stretch-blow moulding a preform (5) is also disclosed.
Visitors’ memories of wildlife tourism: Implications for the design of powerful interpretive experiences

One of the aims of wildlife tourism is to educate visitors about the threats facing wildlife in general, and the actions needed to protect the environment and maintain biodiversity. To identify effective strategies to achieve this aim, this paper examines participants’ memories of their wildlife tourism experiences and explores processes through which such experiences can lead to long-term changes in conservation behaviour. Findings are based on 240 visitors’ extended open-ended responses to a follow-up web survey administered approximately four months after a visit to one of four marine-based wildlife tourism venues in Southeast Queensland. Qualitative analysis revealed four levels of visitor response to the experience, implying a process involving what visitors actually saw and heard (sensory impressions), what they felt (emotional affinity), thought (reflective response), and finally what they did about it (behavioural response). Recommendations are provided for ways tourism managers and wildlife interpreters can maintain and strengthen these dimensions of memorable experiences in order to enhance visitor satisfaction and encourage visitors’ long-term adoption of environmentally sustainable practices.