SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Phenotypic and genetic characterization of adult T-cell acute lymphoblastic leukemia with del(9)(q34);SET-NUP214 rearrangement

SET-NUP214 rearrangement is a recently recognized recurrent chromosomal translocation mostly observed in T-ALL. In order to characterize this rare entity, we performed phenotypic and genetic characterization of SET-NUP214 rearrangement through an investigation of a series of 40 consecutive samples of adult T-ALL that was selected among 229 adult ALL cases during 4 years in a single institution. Four cases (10%) of SET-NUP214 translocation were identified in our study. In all cases, diagnosis of T-ALL was established according to the World Health Organization (WHO) classification, and clonal TCR rearrangements were found. The immunophenotypic markers were indicative of the precursor nature of T lymphoblasts, and they expressed one or both of the myeloid-associated antigens (CD13, CD33). Conventional cytogenetic analysis revealed complex chromosomal aberrations in all four SET-NUP214 rearranged cases and del(12)(p13)/ETV6 was frequently involved. Array-CGH demonstrated additional genomic imbalances in addition to deletion 9q34. The genomic breakpoint sequencing identified breakpoints at SET intron 7 and NUP214 intron 17, and random nucleotide addition was found in two cases at the site of rearrangement. Our independently derived data set from a single institution confirms previous findings of SET-NUP214 rearrangement, indicates the relatively high incidence of SET-NUP214 rearrangement in adult T-ALLs, and also demonstrates comprehensive clinical, phenotypic, and genetic characteristics of this entity. Also, our report on genomic breakpoints demonstrates the homogeneity in the localization of the genomic breakpoints at 9q34. Concurrent chromosomal aberrations identified in this study should provide further areas of interest in investigation of SET-NUP214-mediated leukemogenesis.
Entrevista com Sophie Moirand: Análise de discursos comparativa e relações com o Brasil e a América Latina

Esta entrevista aconteceu em fevereiro de 2022 via videoconferência. O objetivo foi conhecer melhor o percurso acadêmico de Sophie Moirand, suas ligações com a América Latina e o desenvolvimento da Análise de Discursos Comparativa, abordagem da qual ela é uma das fundadoras. A linguista argumenta que a ótica comparativa pode ser considerada algo que se constrói metodologicamente de acordo com cada objeto de estudo, mais do que uma perspectiva cujas teorias e possibilidades já estão completamente fixadas. Com bom humor e extrema generosidade no compartilhamento de seus conhecimentos e experiências, ela transforma a entrevista em uma verdadeira conversa, em uma troca rica e interessante que começa antes mesmo de as perguntas serem feitas. Descobrimos, assim, logo no início, que seu percurso acadêmico começa na área do Francês Língua Estrangeira (FLE), que foi o responsável por seus primeiros contatos com a América Latina, além de ser o motor propulsor que levará a pesquisadora ao encontro da Análise do Discurso. Veremos, assim, o quanto seu percurso acadêmico entrelaça-se com suas jovens experiências profissionais, como o interesse precoce pelo discurso jornalístico/midiático em Argel, na Argélia. Observaremos também que a construção de um percurso acadêmico não era mais fácil no passado do que hoje.
A new fuzzy decision-making approach for selecting new product development project

The most crucial factor that survives enterprises under stiff competition is the success of new product development project; thus, the new product development project selection has become the vital concerns of R&amp;D managers. The initial stage of the project is filled with uncertainties and complexities, which significantly deteriorate the success of product development and product launch. Previous researches focus on helping enterprises determine a set of good product ideas; however, when proceeding to the product development stage after the fuzzy front end, a best product idea should be selected to form a new product development project to create anticipated profits and develop competitive advantage. Therefore, this study proposes a potential project selection model, which combines optimal aggregation method and effective fuzzy weighted average to assist decision maker to achieve the best consistency of fuzzy judgments, and generates a single synergistic index project fuzzy synthetic rating that considers both risk and performance. The project fuzzy synthetic rating index is then used to help make the project Go-Kill decision, and the remaining survival projects are next prioritized to filter the best project. This model can efficiently assist R&amp;D managers in dealing with both uncertainties and complexities when making new product development project screening decision and can reduce decision bias and produce new product development project with the highest possibility of generating expected profit.
ELECTRIC CIRCUIT FOR IGNITING A DISCHARGE LAMP AND METHOD FOR IGNITING THE DISCHARGE LAMP

The invention relates to an electric circuit (1) for igniting at least one discharge lamp (50) by applying at least one voltage pulse (30, 31, 32, 33) to an electrode (51, 52) of the discharge lamp. The invention also relates to a method for igniting the discharge lamp by applying the voltage pulses to the electrode. The circuit is configured in such a way that in order to ignite the discharge lamp at least two chronologically successive voltage pulses (30, 31) can be generated at a pulse interval (34) of 2.5 ns to 5 mu s. The voltage pulses can be advantageously generated at a sequential frequency ranging from 100 kHz - 200 MHz . The high frequency voltage pulses are transmitted to the electrode of the discharge lamp, where ionization of the gas contained in the discharge lamp occurs as a result of said voltage pulses. The electric circuit consists in particular of two galvanically separated oscillation circuits. Starting from a primary oscillation circuit, the voltage pulses are generated in a secondary oscillation circuit with the aid of a high-performance transformer (40). The electric circuit is suitable for igniting a discharge lamp which is operated with square-wave alternating current.
SusTEn Mechanism (Sustainable Tourism Entrepreneurship Mechanism): Approaching Territorial Sustainability through Developing Tourism and Culture based Entrepreneurship

SusTEn stresses on Sustainable Natural and Cultural Resources’ Management, taking as cornerstone the Sustainable Regional Socio-economic Development and specifying on Sustainable Tourism Businesses. The concept stands on the fact that -as shown by international practice- territorial scale sustainable development interventions: -Constitute parameters of vital importance for implementing socio-economic National and EU policies. -Presuppose strategies, policies and measures inspired from: a) Integrated approach on sustainable socio-economic growth, b) Synthetic exploitation of comparative advantages, c) Active and wide participation of all Actors concerned. -Can utilize sustainable tourism as a sound basis upon which economic development could be built, whilst effective strategies for sustainable natural and cultural resources’ management could be deployed. SusTEn addresses the corresponding needs through: --Focusing on sustainable tourism and its various forms, as well as on the improvement of competitiveness at products’ and territories’ levels. --Designing and establishing an integrated framework to effectively support and promote territorial level sustainable tourism initiatives and involving qualified tourism enterprises and local Actors of all related categories. --Acting both locally and internationally for achieving significant added value from the knowledge and know–how point of view, as well as for achieving wide promotion of the territories and their assets targeted.
Electrospun chitosan–gelatin nanofiberous scaffold: Fabrication and in vitro evaluation

In this study, chitosan and gelatin solutions were blended at five different ratios. Samples were fed into electrospinning apparatus to produce non-woven nanofibrous mats. Scanning electron microscopy (SEM) showed that the low-viscosity sample with 30% chitosan and 70% gelatin (sample 30/70) formed the least amount of beads and droplets and yielded fibers with the highest morphological uniformity. To examine the effect of processing parameters on fibers morphology and nanofibers diameter, flow rate, voltage and distance between needle to the collector were changed in the sample 30/70. SEM revealed that high voltages (25 kV) and flow rates (1.5 ml·h⁻¹) decrease the uniformity of fibers and lead to bead and droplet formation. It has also shown that the distance between the tip and the collector have no significant effect on fibers' structure. The values of 15 kV (voltage), 0.2 ml·h⁻¹ (flow rate) and the fixed distance of 15 cm were identified as the optimal electrospinning conditions, which produce fibers with a mean diameter of 180±20 nm. Fourier transform infrared (FTIR) experiment revealed an increase in N-H bending and decrease in C-O stretching vibration in both chitosan and gelatin at 1060 and 1148 cm⁻¹. The in vitro biocompatibility tests performed with human skin fibroblasts showed excellent cell proliferation (MTT assay) and attachment (SEM) on these scaffolds confirming its highly acceptable biological properties.
Assessing the risk between vaccination status and infections within COVID-19 families in Spain

Background: It's unclear whether vaccination individuals against SARS-CoV-2 protects family members in the same way.Objective: The assessment of risk factors for SARS-CoV-2 transmission from index cases with COVID-19 breakthrough infection in completely vaccinated patients to fully vaccinated family members. Methods:From February 1 to November 30, 2021, an observational, longitudinal, and prospective research of families with one primary case of COVID-19 breakthrough infection was done in a general medicine practice in Toledo, Spain.Results: Thirteen primary cases of COVID-19 breakthrough infection in 13 families with at least one other family member were included, of which 9 were positive secondary cases (sick) and 8 were negative partners (healthy) properly vaccinated.Being a woman, being over 45 years old, being a social-health professional, being an ethnic minority, and having chronic conditions all increased the likelihood of developing COVID-19 in fully vaccinated contacts and main cases.Although vaccination 2ChAdOx1 nCoV-19 had a higher effectiveness than BNT162b2 mRNA, none of these risk or protective factors were statistically significant. Conclusion:Young women, social health workers, ethnic minority groups, and people with chronic diseases are the completely vaccinated contacts with the highest risk of having COVID-19, after primary cases also vaccinated in the family, in Toledo (Spain), when the delta variant became dominant but before the rise of omicron.
LIQUID POLYMERIC COATING COMPOSITIONS AND AIR BAGS COATED THEREWITH

A coating composition for air bag fabrics is disclosed, the composition being comprised of liquid silicone rubbers and liquid organic polymers that are chemically reacted to form cross-linked polymer networks with silicone and non-silicone components. By adding liquid organic polymers to liquid silicone rubber compounds as described herein, coatings for air bags that show increased retention of the inflating air have been discovered. Beneficially, the production of these coatings is achieved without the use of organic solvents. An air bag coated with the present formulation is also disclosed.
Enrich in the usa

The ENRICH in the USA project is the continuation of the 42-months long NearUS project (2017-2020), aiming to set up and pilot the European Network of Research and Innovation Centre and Hub in the USA. The objective of the ENRICH in the USA is to capitalise on the NearUS experience, to reinforce the Network and support innovation exchange and commercialization across the Atlantic by educating, preparing, mentoring, and supporting European Research and Innovation actors. ENRICH in the USA serves the needs of EU innovators by providing standardized services and offering soft-landing opportunities across the USA, including through sector-specific Landing Hubs, as such embedding them into welcoming and nurturing local ecosystems. The services are built around three pillars: Education, Connections and Soft-landing. Furthermore, ENRICH in the USA aims to be accessible to innovation stakeholders from all EU MS/AC, and to especially support “underserved” entrepreneurs in Europe, as such unlocking their hidden potential. The business plan of ENRICH in the USA envisages a sustainable path through growing revenues from the Network activity. ENRICH in the USA is building a brand in Europe and the US, providing a long-term asset and return on investment to the European Union.
Boosting the implementation of participatory strategies on separate paper collection for efficient recycling

The European paper industry is at the core of the bioeconomy, using wood, a renewable material, and Paper for Recycling (PfR) as its main raw materials for producing paper products. This industry is a strategic sector in the EU economy, actively contributing to the re-industrialisation of Europe. Currently, the production of paper and board in the EU is 91 tonnes per year, while PfR represents 63%. The contribution of PfR has increased over the last few years (from 25 t to 40 t).
This increase in the availability of PfR has not taken place in all EU states, and this is especially true in Eastern European countries. Besides, although high collection rates are achieved, the quality of this material does not always meet the requirements of paper recycling. Both facts make difficult to keep up with the increases in PfR collection rates observed over the last few years if specific actions are not taken.
IMPACTPapeRec aims to put Europe at the forefront of PfR collection, ensuring raw material procurement from mainly European sources through an innovative approach based on the participation of the whole paper value chain including citizens and municipalities, which is also open to other sectors. Main objective is to provide an innovative and common knowledge platform, which will enable present and future cooperation. Analysis on best practices in PfR collection and assessment procedures are delivered, considering specific local conditions. They will encourage reliable decisions and make solutions available to decision-makers ensuring the procurement and supply of PfR in Europe through the improvement of municipal paper collection. Medium-long results are: increases in PfR collection (up to 75%); 1.57 Mt/year and raw material savings of €385 million.
This proposal has positive support from the EU of the commitment approved within the EIP on raw materials “IMPACT - Introduction and Improvement of Separate Paper Collection to avoid landfilling and incineration”.
Small-molecule organic solar cells with multiple-layer donor

Small-molecule organic solar cells (OSCs) with a multifunction three-layer donor are experimentally investigated to achieve higher power conversion efficiency. The proposed OSC has an indium tin oxide (ITO, anode)/three-layer donor/fullerene (C60, acceptor, 40 nm)/bathocuproine (BCP, cathode buffer, 10 nm)/Ag (cathode, 100 nm) structure. The three-layer donor is composed of 3-nm-thick pentacene/20-nm-thick copper phthalocyanine (CuPc)/5-nm-thick aluminum phthalocyanine chloride (ClAlPc). The OSC achieves a power conversion efficiency of 1.79%, which is 1.7 times as large as that for an OSC with a single-layer donor of 20-nm-thick CuPc. Atomic force microscopy observation is carried out to clarify in detail the surface morphology at typical organic layers. The acceptor C60 is in contact not only with ClAlPc but also with CuPc due to the vertical and wall-like growth of the ClAlPc layer. The open-circuit voltage for the OSC with the ClAlPc/C60 contact is 0.56 V, compared with 0.47 V for the OSC with the CuPc/C60 contact. The thin pentacene layer is uniformly grown on the ITO and serves to achieve a high short-circuit current density Jsc by lowering the barrier height for hole transport between ITO and CuPc. Jsc for the OSC with the thin pentacene layer is 5.60 mA/cm2, compared with 4.32 mA/cm2 for the OSC without the thin pentacene layer.
Organic light emitting display

An organic light emitting display (OLED) includes a substrate (105), first (110A) and second (110B) driving units positioned on the substrate, a first light emitting diode (120;LED) connected with the first driving unit and including a first organic light emitting layer (140) and a second emitting diode (160) electrically connected (195) with the second driving unit and including a second organic light emitting layer (180). The second emitting diode (160) is positioned on the first emitting diode (120).
Media, Militarization, and Human Rights: Comparing Media Reform in the Philippines and Burma

Thoseworkingtodevelopandreformmediaoftendrawonhumanrightsdiscourse,especially in areas of political violence. Yet discours er ef lecting globally dominant conceptions of individually based human rights can have detrimental effects. This study illustrates how militarizationand this discourse of human rights can be mutually reinforcing, and explores the impact of this phenomenon on media and reform efforts. We examine as case studies the efforts to reform and develop media in the Philippines and Burma (Myanmar), both militarized states with severely constrained political discourse. As a result, media freedom and reform efforts tend to center on the safety and individual rights of journalists rather than on media as a public service, a political and social force accessible to all. doi:10.1111/j.1753-9137.2011.01107.x Those working to develop and reform media often draw on human rights discourse in lobbying for free and publicly responsible media, especially in areas of political violence. Yet discourse reflecting the globally dominant, individually based conception of human rights can have detrimental effects. This study illustrates how ‘‘militarization’’ and this discourse of human rights can be mutually reinforcing, and explores the consequences for media and media reform efforts. We examine as case studies the efforts to reform and develop media in the Philippines and Burma (Myanmar), 1 both militarized states with severely constrained political discourse. As aresult,mediafreedomandreformefforts tendtocenteronthesafetyandindividual rights of journalists rather than the role of media as a public service, a political and social force accessible to all. That militarization and human rights discourse are mutually reinforcing in the Philippines and Burma suggests that this phenomenon may be at play elsewhere as well. Individual journalists are easier to control than groups lobbying for structural change, and the focus on press freedom, while important, arguably provides a (less threatening) distraction from such collective demands. This lends weight to the
DIGitalisation of multimodal transport in the Adriatic SEA

The Interreg IT-HR 2014-2020 Programme developed several projects dealing with freight transport, four of them focusing on ICT applied to maritime and multimodal transport, from different perspectives.
PROMARES assessed the use of ICT solutions in the port-hinterland domain.
INTESA focused on the port-sea relation, with the goal of harmonizing and optimizing the procedures of the maritime transport processes.
DigLogs looked into improving information flows of transport processes on freight movements, status and authorizations.
TRANSPOGOOD developed an innovative ICT tool to find the best solution of transport services (e.g., best price of combined transport),
DIGSEA clusters the technical knowledge developed by these projects and consolidates it in a single sea-port-hinterland-logistics approach, covering the whole supply chain.
This way, the experiences and expertise of the current programming period will serve as a basis for the new one, ensuring their long-term sustainability and replicability.
Also, they will be transferred to stakeholders and policy makers at EU and transnational level, to engage them and raise the awareness of the use of ICT as a powerful and efficient tool to improve the efficiency and consequently the environmental performance of ports and the whole supply chain.
Long-term culture of pluripotent stem-cell-derived human neurons on diamond – A substrate for neurodegeneration research and therapy

Brain Computer Interfaces (BCI) currently represent a field of intense research aimed both at understanding neural circuit physiology and at providing functional therapy for traumatic or degenerative neurological conditions. Due to its chemical inertness, biocompatibility and stability, diamond is currently being actively investigated as a potential substrate material for culturing cells and for use as the electrically active component of a neural sensor. Here we provide a protocol for the differentiation of mature, electrically active neurons on microcrystalline synthetic thin-film diamond substrates starting from undifferentiated pluripotent stem cells. Furthermore, we investigate the optimal characteristics of the diamond microstructure for long-term neuronal sustainability. We also analyze the effect of boron as a dopant for such a culture. We found that the diamond crystalline structure has a significant influence on the neuronal culture unlike the boron doping. Specifically, small diamond microcrystals promote higher neurite density formation. We find that boron incorporated into the diamond does not influence the neurite density and has no deleterious effect on cell survival.
How conversations around campfires came to be

Fire and conversation are two things that have been of crucial importance for our evolutionary story, yet they have received only rather casual attention. Yes, we know that fire was used for cooking (probably casually at first, but later as a matter of regularity), and, yes, we know that language evolved at some point and has been important for human culture. However, there has been a longstanding tendency to take these two phenomena for granted as something self-evidently useful and hence presumably of ancient origin. In PNAS, Wiessner (1) brings these two phenomena together in a way that has significant implications for our understanding of both why they evolved and when they did so. In the first such study of its kind, she recorded the topics of conversation during the day and around the campfire at night among a group of Ju’/hoansi (or !Kung) Bushman in Botswana, a people whose living hunter-gatherer ecology is similar to that which characterized most of our evolutionary history. In this sample, most daytime conversations were functional (discussions of land rights, economic matters, norm regulation), but most evening conversations were social (more than 80% were stories). Stories are important in all societies because they provide the framework that holds the community together: we share this a set of cultural knowledge because we are who we are, and that is why we are different from the folks that live over the hill.