SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Relationship between CCR2-V64I polymorphism and cancer risk: A meta-analysis

The role of CCR2-V64I polymorphism in various cancers has been reported in many studies. However, results from published studies on the association between CCR2-V64I polymorphism and cancer risk are conflicting. Therefore, we performed a meta-analysis to estimate the overall cancer risk associated with the polymorphism.Electronic searches of PubMed and EMBASE were conducted for all publications on the association between this variant and cancer. Odds ratios (OR) with 95% confidence intervals (95% CI) were used to access the strength of this association.Sixteen studies with 2661 cancer patients and 5801 healthy controls were included. Overall, significant association was found between the CCR2-V64I polymorphism and cancer risk (OR=1.84, 95% CI=1.35-2.51, AA vs GA/GG, P=0.37). In the subgroup analysis stratified by cancer types, there was a significant association between this polymorphism and bladder cancer (OR=2.06, 95% CI=1.02-4.15, AA vs GA/GG, P=0.11), cervical cancer (OR=3.34, 95% CI=1.48-7.50, AA vs GG, P=0.56), and oral cancer (OR=2.04, 95% CI=1.46-2.84, GA vs GG, P=0.70). In the subgroup analysis stratified by ethnicities, an increased cancer risk was also found in Europeans (OR=2.31, 95% CI=1.45-3.68, AA vs GA/GG, P=0.16) and Asians (OR=1.88, 95% CI=1.12-3.16, AA vs GA/GG, P=0.92).This meta-analysis suggested that CCR2-V64I polymorphism may contribute to an increased risk of cancer.
Segregación socioespacial en el acceso a equipamientos de salud en Mazatlán, México

El artículo propone analizar la estructura urbana de Mazatlán con relación a la distribución espacial de los grupos derechohabientes y los equipamientos de salud pública y privada. Se retoma el concepto de segregación socioespacial desde la exclusión de los grupos sociales de las dinámicas de provisión de infraestructura y de servicios por motivo de su condición socioeconómica (MURILLO ET AL. 2011; SABATINI, 2003) y la accesibilidad a los equipamientos de salud desde de la distancia que separa a los usuarios potenciales del punto de servicio (GARROCHO, 1993; BASS, 2015). La metodología involucra el mapeo de datos estadísticos oficiales (INEGI, CONAPO), con respecto a indicadores socioeconómicos y de marginación urbana, y cómo es su vinculación con la accesibilidad a los equipamientos de salud. Se concluye que los derechohabientes del INSABI se encuentran mayormente segregados para acceder a los equipamientos de salud, en tanto que requieren recorrer mayores distancias y disponen de menor infraestructura de transporte público.
Development and validation of RP-HPLC method for the determination of doxycycline hyclate in spiked human urine and pharmaceuticals

An accurate, sensitive, precise, rapid, isocratic reversed phase HPLC (RP-HPLC) method for the determination of doxycycline hyclate in bulk drug and in tablets, and also in spiked human urine, was developed and validated. The best separation was achieved on a 250 mm × 4.0 mm i.d, 5.0 µm particle size C 8 reversed phase thermo column with acetonitrile-potassium dihydrogenorthophosphate buffer (pH 4.0), 40:60 (v/v) as mobile phase at a flow rate of 1.0 mL/min. UV detection was performed at 325 nm at ambient column temperature (25 °C). The method was linear over the concentration range of 30-300 µg/ mL (r=0.9994) with limits of detection and quantification of 0.02 and 0.1 µg/ mL, respectively. The drug was subjected to oxidation, acid and base hydrolysis, photolysis and heat as stress conditions. Degradation products were found interfering with the assay of doxycycline hyclate only in oxidation and base hydrolysis, therefore the method can be regarded as indicating stability in the case of acid hydrolysis, photolysis and heat stress conditions. The method was applied for determination of doxycycline hyclate in pharmaceuticals and spiked human urine with excellent recoveries. The method can be used for the quality control of doxycycline hyclate.
An assessment and treatment tool for visual dysfunctions in children

It is estimated that approximately 30-50% of the general population in children (5-15 years old) suffer from some visual functional dysfunctions, and 10% of them have a serious impairment that affects their daily life. Nevertheless, once detected such dysfunctions can be improved in 95-100% of the cases through training or therapy, but only 2% of these patients are being treated. To solve this problem, we have developed WIVI.
WIVI is an assessment and treatment tool for visual dysfunctions detection based on immersive 3D techniques, which examines in a multiparametric way the visual system in its full extension, i.e., it provides a complete cognitive, neural and physic phases assessment. WIVI reduces the standard treatment period from 6 months to 2,5 months, and each session duration is reduced by 75%. Price wise, WIVI allows to save between 58% up to 85% of the total cost of current alternatives. Our product has been tested on 15 children between 5 and 17 years old and on 40 adults in the age range 18 to 70, reaching 95% of accuracy in measurements.
The global clinical devices for the visual function assessment market is anticipated to grow from an estimated USD 29,171 million in 2014 to USD 42,685 million in 2020 at a CAGR of 6.5% during the forecast period. The overall objective of the WIVI business project is to establish WIVI as a worldwide standard in visual dysfunction assessment and treatment, supporting it in real-time high detection rates, cheaper and faster clinical practices.
A Lightweight Evaluation Framework for Table Layouts in MapReduce Based Query Systems

Table layout determines the way how the relational row-column data values are organized and stored. In recent years, considerable candidates have been developed in MapReduce based query systems; they differ on storage space utilization, data loading time, query performance and so on. In most time, users are confronted with the problem of choosing the comprehensive optimum table layout given the workloads and the schema of tables. The straightforward way to run queries on generated data and compare the results is time consuming, and incurs the inaccuracy due to the MapReduce’s nondeterministic execution runtime. In this paper, we propose a lightweight framework to evaluate table layouts without running the query. The framework adopts the black box method to test critical metrics, and the query aware strategy that extracts table-layout-related operations from query. Based on the metrics and operations, the framework makes suggestions to users. We conduct extensive experiments to empirically study the popular table layouts. Through the results illustration, we discover that column projection and compression are the most two prominent factors for general cases. Moreover, we discuss optimization chances for the intermediate tables produced in high level language systems.
Efficient FPGA Cost-Performance Space Exploration using Type-Driven Program Transformations

Many numerical simulation applications from the scientific, financial and machine-learning domains require large amounts of compute capacity. They can often be implemented with a streaming data-flow architecture. Field Programmable Gate Arrays (FPGA) are particularly power-efficient hardware architectures suitable for streaming data-flow applications. Although numerous programming languages and frameworks target FPGAs, expert knowledge is still required to optimise the throughput of such applications for each target FPGA device. The process of selecting which optimising transformations to apply, and where to apply them is dubbed Design Space Exploration (DSE). We contribute an elegant and efficient compiler based DSE strategy for FPGAs by merging information sourced from the compiled application's semantic structure, an accurate cost-performance model and a description of hardware resource limits for particular FPGAs. Our work leverages developments in functional programming and dependent type theory to bring performance portability to the realm of High-Level Synthesis (HLS) tools targeting FPGAs. We showcase our approach by presenting achievable speedups for three example applications. Results indicate considerable improvements in throughput of up to 58× in one example. These results are obtained by traversing a minute fraction of the total Design Space.
Generation and manipulation of quantum sound

Quantum physics has been at the very heart of understanding the inner workings of nature and has led to the beginning of a modern technological revolution. Over the past decades, more and more physical systems have been used in quantum experiments. Yet, despite their tantalizing theoretical potential, full and comprehensive quantum control over phonons, in particular of traveling acoustic waves, has remained an elusive goal, mainly due to technical challenges. I have recently been part of the exciting new developments that set the stage for the field of quantum acoustics. I now propose to investigate novel regimes and applications of quantum physics with quantum excitations of mechanical waves at the nanoscale. My aim is to be able to control acoustic phonons to the same level as we currently achieve in the manipulation of optical photons in quantum optics.
I will use new concepts like on-chip phonon routing, filtering, delaying and single-phonon detection to achieve full quantum control over individual phonons. Q-ECHOS is based on novel ideas and approaches, which have only recently become experimentally accessible through state-of-the-art photonic crystal-based quantum optomechanical systems realized in my group. This will allow for the observation of new physical phenomena, understand the decoherence mechanisms of other quantum systems, create hybrid quantum devices and open up completely new possibilities for quantum information processing.
The research will not only have lasting impact on optomechanics and quantum physics, but will also pave the way for new technologies, such as quantum transducers for sensor applications, as well as for novel classical communication technologies. The breakthroughs in quantum optomechanics and my strong track record in this area will allow me to achieve exciting results through Q-ECHOS that will break new grounds.
Design of bull’s eye structures on gate-defined lateral quantum dots

Quantum repeaters are required for realizing long-distance quantum communication. The quantum repeater consists of a quantum memory to store quantum information and an interface between photonic flying qubits and the memory qubits. Electron spins in gate-defined quantum dots (QDs), which have a relatively long coherence time and high electrical tunability, are promising candidates for such memory qubits because the fundamental technologies of detecting and manipulating single photoelectron spins have been established. The remaining challenge for the realization of quantum repeaters is an efficient coupling between photons and electron spins in the QDs. In this study, we discuss the enhancement of the transmission and the maintenance of the incident light polarization through bull's eye structures on gate-defined QDs on the basis of electromagnetic field simulations.
Probabilistic Compositional Reasoning for Guaranteeing Fault Tolerance Properties

AbstractWe present a framework to formally describe system behavior and symbolically reason about possible failures. We regard systems which are composed of different units: sensors, computational parts and actuators. Considering worst-case failure behavior of system components, our framework is used to derive reliability guarantees for composed systems. The behavior of system components is modeled using monad like constructs that serve as an abstract representation for system behavior. We introduce rules to reason about these representations and derive results like, e.g., guaranteed upper bounds for system failure. Our approach is characterized by the fact that we do not just map a certain component to a failure probability, but regard distributions of error behavior. These serve as basis for deriving failure probabilities.KeywordsFailure ProbabilitySystem DescriptionFault ToleranceWork PieceConveyor BeltThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
New Bell inequalities for three-qubit pure states

We introduce a set of Bell inequalities for a three-qubit system. Each inequality within this set is violated by all generalized GHZ states. More entangled a generalized GHZ state is, more will be the violation. This establishes a relation between nonlocality and entanglement for this class of states. Certain inequalities within this set are violated by pure biseparable states. We also provide numerical evidence that at least one of these Bell inequalities is violated by a pure genuinely entangled state. These Bell inequalities can distinguish between separable, biseparable and genuinely entangled pure three-qubit states. We also generalize this set to n-qubit systems and may be suitable to characterize the entanglement of n-qubit pure states.
DEVICE FOR ACTUATING SLIDES IN AN INJECTION MOULDING TOOL

A device is disclosed for actuating slides (3, 4, 9, 24, 26) in an injection moulding tool for elastomer mixtures having a cavity (10) delimited by slides (3, 4, 9, 24, 26). The slides may be separately driven by an actuating cylinder. A single actuating member (21, 12, 33, 34) is associated to all slides.
Comparing limb-volume measurement techniques: 3D models from an infrared depth sensor versus water displacement

In our previous work, a new method for measuring limb volume based on infrared depth sensors was presented. The system, which can be operated in the comfort of our homes, allows for the early detection of swelling associated with lymphedema - a chronic disease caused by failure in the lymphatic system. Early detection and management can significantly reduce the potential for symptoms and complications; however, many patients fail to seek medical assistance at the first sign of the disease. So, the proposed system can potentially affect the lives of nearly 500,000 people in the U.S. who suffer from lymphedema with over 2.6 million breast cancer survivors and over 230,000 new cases every year <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1</sup> who are at-risk for developing this disease at some point in their life. In this paper, a series of improvements made to the system is presented. The changes led to the complete automation of the process of 3D imaging the arms. The proposed technique for limb-volume measurement was compared with the water displacement and the perometry. Being an ongoing research, the results presented here are limited to 14 arms of healthy volunteers. In the future, test will include a larger number of limbs of healthy as well as cancer patients.
AMPLIFIED FLOW THROUGH PRESSURE SENSOR

A MEMS based pressure sensor for flow measurements includes a pressure sense die located between a media seal and a conductive seal. Such a system includes a pressure sense die located between a media seal and a conductive seal. A sensing diaphragm is generally associated with the pressure sense die, wherein the sensing diaphragm deflects when a pressure is applied thereto. An impedance circuit is generally embedded with one or more resistors on the sensing diaphragm to which the pressure to be detected is applied. An ASIC is generally associated with the impedance circuit and the sense die, wherein the ASIC is placed on a lead frame for signal conditioning in order to detect a change in the pressure.
Device, method and system for implementing a physical area network for cancer immunotherapy

A physical area network described herein enables significantly improved health monitoring and treatment by utilizing internal (in-body) mechanisms and information and external mechanisms and information.
Modulation of Marine Low Clouds Associated with the Tropical Intraseasonal Variability over the Eastern Pacific

Abstract Owing to its profound influences on global energy balance, accurate representation of low cloud variability in climate models is an urgent need for future climate projection. In the present study, marine low cloud variability on intraseasonal time scales is characterized, with a particular focus over the Pacific basin during boreal summer and its association with the dominant mode of tropical intraseasonal variability (TISV) over the eastern Pacific (EPAC) intertropical convergence zone (ITCZ). Analyses indicate that, when anomalous TISV convection is enhanced over the elongated EPAC ITCZ, reduction of low cloud fraction (LCF) is evident over a vast area of the central North Pacific. Subsequently, when the enhanced TISV convection migrates to the northern part of the EPAC warm pool, a “comma shaped” pattern of reduced LCF prevails over the subtropical North Pacific, along with a pronounced reduction of LCF present over the southeast Pacific (SEPAC). Further analyses indicate that surface latent heat fluxes and boundary heights induced by anomalous low-level circulation through temperature advection and changes of total wind speed, as well as midlevel vertical velocity associated with the EPAC TISV, could be the most prominent factors in regulating the intraseasonal variability of LCF over the North Pacific. For the SEPAC, temperature anomalies at the top of the boundary inversion layer between 850 and 800 hPa play a critical role in the local LCF intraseasonal variations. Results presented in this study provide not only improved understanding of variability of marine low clouds and the underlying physics, but also a prominent benchmark in constraining and evaluating the representation of low clouds in climate models.
Entre redes e coletivos docentes latino-americanos:

Este artigo tem como foco experiências entre redes e coletivos docentes latino-americanos, no contexto da pandemia provocada pelo vírus Sars-Cov-19, tomadas como movimentos de investigaçãoformação. A partir da trajetória da Rede de Docentes que Narram sobre Infância, Alfabetização, Leitura e Escrita (REDEALE) e do desejo de pensarfazer a formação e a educação entre pares latino-americanos, destacamos dois movimentos dialógicos vivenciados no ano de 2020: o “Projeto Memórias da Quarentena: Diálogos entre Brasil e Peru e a participação na Red Cómplices Pedagógica de Educadores Latinoamericanos. Referenciadas em uma perspectiva qualitativa e dialógica, a reflexão sobre tais experiências nos possibilitou reafirmar a importância do diálogo entre redes como uma experiência instituinte; a indissociabilidade das dimensões pedagógicas e política dos processos educativos; e a importância do movimento coletivo de luta latino-americano pela educação como prática de liberdade e humanização.&#x0D;
Optical manipulation of colloidal interfaces, droplets and crystallites

This multidisciplinary research programme is focussed on the optical manipulation of interfaces, droplets and crystallites in colloidal model systems. In particular, we will use holographic optical tweezing and confocal microscopy to study interfacial phenomena in three different phase separated colloid-polymer mixtures, exhibiting colloidal liquid-gas, crystal-gas and nematic-isotropic phase coexistence, respectively. First, we will determine the full potential energy landscape of the optical traps using the relation between interface fluctuations and deformed liquid-gas interfaces. This will then be used to study the complex and anisotropic interfacial properties of crystal-gas and nematic-isotropic interfaces. In addition, we envisage quantitatively investigating the nucleation of colloidal liquid droplets, crystallites and liquid crystalline droplets in optical traps positioned at well-defined heights above the interface, which is a direct and quantitative measure for the undersaturation. This allows us to systematically study the relation between the quench depth, nucleus size and nucleation times. We will furthermore nucleate multiple droplets, crystallites and liquid crystalline droplets to study their optical trapping controlled coalescence and detachment, which will shed completely new light on for instance the single particle structure and dynamics upon coalescence and detachment. Finally, we will introduce large probe particles into the phase separated colloid-polymer mixtures, which enables the study of important phenomena such as heterogeneous nucleation and capillary condensation, crystallisation and nematisation. This ambitious project opens up a huge range of exciting possibilities to gain a deep and fundamental understanding of interfacial phenomena in complex fluids by actively manipulating and controlling colloidal interfaces, droplets and crystallites.
ACCOUNTING FOR URBAN CHINA'S RISING INCOME INEQUALITY: THE ROLES OF LABOR MARKET, HUMAN CAPITAL, AND MARRIAGE MARKET FACTORS

This paper analyzes China's rising family income inequality since the early 1990s when the urban labor market started its transformation from a centrally controlled to a market‐driven one. We document the trends in income inequality over the period of 1992–2009 using the Urban Household Survey data, and adopt the approach recently proposed by Eika et al. (2014) to decompose changes in income inequality. We find that labor market factors accounted for about three‐quarters of the overall increases in income inequality while falling marriage rate contributed the other quarter. Changes in human capital levels and marital assortativeness have not contributed to the rising inequality. (JEL D31, I26, J12)
Student Transnational Entrepreneurship Program

This project of inclusive growth is at the heart of the Europe 2020 strategy and aims to strengthen entrepreneurial culture by supporting student entrepreneurship in the blue and green growth priority sectors of the transnational FR-IT area. The general objective of the STEP project is to provide entrepreneurial skills to students so that they are better prepared to enter the labour market, promote new business opportunities in the field of blue and green growth and support higher student mobility in the transnational area. STEP’s actions should improve the employability of young people and their access to the labour market. There are three key objectives. The first will make students aware of entrepreneurship and the identification of good cross-border practices. The second will promote the development of entrepreneurial skills for students with a business creation training and action course. The third will promote transnational mobility and professional opportunities for student entrepreneurs by creating a "STEP" resource centre cross-border pilot network in universities and their entrepreneurial ecosystems. This project will support the professional vocations of students and young graduates, by providing them with entrepreneurship training and increasing their awareness of transnational opportunities in the blue and green growth priority sectors. The project will promote the exchange of knowledge and transnational mobility in two ways. One will be the organisation of a cross-border competitive exam where young people who took the training and action course will have the opportunity to submit their projects. The other will be the creation of a network of cross-border mobility support structures specially adapted to student entrepreneurs.