SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Design, history and results of the Thiazolidinedione Intervention with vitamin D Evaluation (TIDE) randomised controlled trial

Conflicting data regarding cardiovascular effects of thiazolidinediones (TZDs) and extra-skeletal effects of vitamin D supported the need for a definitive trial. The Thiazolidinedione Intervention with vitamin D Evaluation (TIDE) trial aimed to assess the effects of TZDs (rosiglitazone and pioglitazone) on cardiovascular outcomes and the effects of vitamin D (cholecalciferol) on cancers and mortality.A large multicentre 3 × 2 factorial double-blind placebo-controlled randomised trial recruited from outpatient primary care and specialty clinics in 33 countries. From June 2009 to July 2010, 1,332 people with type 2 diabetes and other cardiovascular risk factors aged ≥ 50 years whose HbA(1c) was 6.5-9.5% (48-80 mmol/mol) when using two or fewer glucose-lowering drugs were randomised by a central computer system to placebo (n = 541), rosiglitazone 4-8 mg/day (n = 399) or pioglitazone 30-45 mg/day (n = 392); 1,221 participants were randomised to placebo (n = 614) or vitamin D 1,000 IU/day (n = 607). Participants and all study personnel were blind to treatment allocation. The primary outcome for the TZD arm was the composite of myocardial infarction, stroke or cardiovascular death, and for the vitamin D arm it was cancer or all-cause death. All randomised participants were included in the primary analysis.From the study design, 16,000 people were to be followed for approximately 5.5 years. However, the trial was stopped prematurely because of regulatory concerns after a mean of 162 days without consideration of the accrued data. In the TZD arm, the cardiovascular outcome occurred in five participants (0.9%) in the placebo groups and three participants (0.4%) in the TZD groups (two allocated to pioglitazone, one to rosiglitazone). In the vitamin D arm, the primary outcome occurred in three participants (0.5%) in the placebo group and in two participants (0.3%) receiving vitamin D. Adverse events were comparable in all groups.Uncertainty persists regarding the clinically relevant risks and benefits of TZDs and vitamin D because of the early cancellation of this comprehensive trial.
Kriging‐based ionospheric TEC, ROTI and amplitude scintillation index ( <i>S</i> <sub>4</sub> ) maps for India

In this study, an attempt is made to develop regional ionospheric total electron content (TEC), rate of TEC index (ROTI) and amplitude scintillation index (S 4) maps using data from 26 dual-frequency global positioning system (GPS) receivers under GPS aided geo-stationary earth orbit augmented navigation programme over Indian region. One-minute spatial TEC maps are generated for the entire Indian region covering 65–100°E geographic longitudes, 5–40°N geographic latitudes with 2° × 2° grid separation using Kriging method. Also, the ROTI and amplitude scintillation index (S 4) maps for every 5 min are generated. The performance of the generated regional TEC maps is evaluated during a severe geomagnetic storm condition. Patterns of equatorial ionisation anomaly (EIA) TEC structures are investigated for St. Patrick's storm between the days 15 and 20 March 2015 with the generated TEC maps. The proposed TEC maps depict the northern crest of EIA features in latitudinal extent and TEC strength. The kriging method detects the suppressed and downshift of EIA features on 18 March 2015. The movement of plasma bubbles are analysed over Indian latitudes during the transition period of a geomagnetic storm on 17 March 2015.
L’engagement organisationnel dans différents contextes institutionnels : comment les contraintes procédurales perçues entravent l’abnégation

L’impact positif de la motivation de service public sur plusieurs résultats individuels dans le travail des employés du secteur public n’est plus à démontrer. Des recherches récentes sur le « côté obscur » de ce trait individuel ont toutefois conduit certains chercheurs à suggérer que les conditions organisationnelles, telles que les contraintes procédurales, pourraient affecter la motivation des personnes, conduisant ainsi à la démission des travailleurs tournés vers les autres. Cette étude explore les relations entre l’une des dimensions de la motivation de service public – à savoir l’ abnégation – les contraintes procédurales et l’engagement organisationnel en étendant le modèle Exigences – Ressources de l’épuisement professionnel de l’engagement organisationnel à différents contextes institutionnels. L’étude utilise une approche mixte qui combine des données quantitatives (modélisation par équation structurelle) et qualitatives (groupes de discussion et entretiens approfondis) provenant de trois secteurs en Italie (santé, administration publique locale et organisations sans but lucratif). Nos résultats montrent que l’abnégation modère positivement la relation négative entre les contraintes procédurales et l’engagement organisationnel. Les résultats mettent également en évidence certains des effets indésirables de l’abnégation auxquels les organisations doivent faire face. Remarques à l’intention des praticiens Les employés motivés de façon désintéressée ont tendance à être plus sensibles aux procédures contraignantes et sont donc susceptibles de ressentir plus durement les effets de ces conditions sur leur engagement. Étant donné que le secteur public est un contexte de travail hautement bureaucratique, les sources et les remèdes à ce problème méritent que les chercheurs et les praticiens de l’administration publique s’y intéressent. Les résultats de l’étude confirment l’intérêt de l’élaboration de pratiques visant à éviter aux employés motivés de façon désintéressée de risquer d’entrer dans un cycle de l’échec et de problèmes psychologiques.
Epithelial Cell Death and Inflammation in Skin

The presence of dying cells in inflamed tissues has been recognized since many years, but until recently cell death was considered primarily a consequence of inflammation. Recent data in mouse models suggest that cell death could provide a potent trigger of inflammation. The identification of necroptosis as a new type of regulated necrotic cell death that is induced by death receptors, toll like receptors and type I interferon receptor indicated that necroptosis could contribute to the proinflammatory properties of these receptors. This is particularly relevant to the skin, a tissue that provides a life-sustaining structural and immunological barrier with the environment and is constantly exposed to mechanical, chemical, and microbial insults. Studies in mouse models showed that sensitization of keratinocytes to apoptosis or necroptosis triggered by TNF and other stimuli causes severe chronic inflammatory skin lesions. In addition, keratinocyte death is a prominent histopathological feature of many inflammatory skin diseases, suggesting that death of epithelial cells could contribute to the pathogenesis of skin inflammation . Here we review recent studies in genetic mouse models providing evidence that keratinocyte death is a potent trigger of skin inflammation and discuss their potential relevance for human inflammatory skin diseases.
APPARATUS FOR AUTOMATIC REGISTRATION OF A CONTINUOUS BULK MATERIAL FLOW BY MEANS OF A RUN-THROUGH WEIGHING DEVICE

The apparatus includes a run-through weighing device (1) consisting of a weighing barrel (6), an adjustable shut-off device (4) for adjusting the exit diameter of the weighing barrel (6) in addition to electronic weight-difference measurement facilities. The shut-off device (4) is in the outlet area of the weighing barrel (6), and connected to the latter by means of a movable partition component, so arranged that when the shut-off device is in open operational position, the bulk material flows freely. At the same time, care is taken to ensure that the flow of loose bulk material from the outlet section of the weighing barrel (6) is unobstructed. In a process to permit automatic registration of the loose bulk material flow in an apparatus of this kind, a suitable signal is sent off and used for the calculation of state parameters of the bulk material for each change in weight occurring per time unit, either when a mass material flow occurs in the entire weighing barrel (6) or when the flow of mass material is totally stopped.
Two Electron Transfer and Stabilization in Slow O 6+ and Rare-Gas Collisions

The stabilization ratios R for double-electron transfer, i.e., the cross section ratios of true double capture to total double-electron transfer, are measured in O6+ +He, Ne and Ar collisions at 6 keV/u. A high R value about 68% is obtained for the He target, while for the Ar target, the R value is only 8%. The high R value for the He target is due to the significant direct population of the (2l, nl') configurations with high n. For the Ar target, the (quasi)symmetric configurations (3l, nl') lead to the much lower R value. Neglecting the core effects, the O6+ ion can be taken as a bare ion C6+ except the occupied 1s shell, and then the measured R values are compared with previous experimental results of C6+ projectile ions at similar impact velocity. It yields good agreement with the Ne and Ar target, while the occupied 1s shell for the O6+ +He system results in a higher R value than that in C6+ +He collisions.
Gibberellic acid signaling and dynamics during arbuscular mycorrhizal symbiosis and rhizobial-legume symbiosis

The association of microbes at the root-soil interface is an ancient adaptation integral for nutrient acquisition. Most land plants, including trees and crops, associate with mutualistic fungi called mycorrhizae. Legumes have adapted specialized root structures termed nodules for association with nitrogen-fixing bacteria (rhizobia). While there are differences among the species that beneficially associate with plants, there is a large overlap in the key players regulating both symbioses. One important regulator is gibberellin or gibberellic acid (GA), a plant hormone that has diverse and important functions in plant growth and development. While GA inhibits infection events, there is conflicting evidence for the role of GA as an important positive and negative regulator of nodule organogenesis. Here, I propose to determine the mechanism of GA regulation in symbiosis in the model plants Medicago truncatula and barley (Hordeum vulgare). My approach combines the use of a state-of-the-art GA biosensor to characterize and model GA fluctuations in symbiosis in combination with transcriptomic and genetic approaches to characterize GA-signaling response in M. truncatula and H. vulgare. Upon completion of this project, we will gain an understanding of the dynamics of GA signaling in symbiosis and define downstream GA targets that are of special interest for engineering enhanced symbiosis in cereal species.
European – canadian partnership for climate-positive heat and power generation through improved biomass feedstock supply and innovative conversion technologies

Climate change is the most significant challenge for humanity today. For this reason, replacement of fossil fuels with renewables and improved energy efficiency in combination with CO2 capture is needed. Among renewables, biomass will play a major role in satisfying the human energy needs.

EUCANwin! will increase viability of the biomass supply chain from forest and develop an efficient heat and power technology with a high share of power production together with negative carbon emissions in international cooperation between EU and Canada.

In particular, to overcome these challenges, EUCANwin! involves artificial intelligence in combination with tools and technologies within the biomass supply chain such as the Forest Biomass Atlas (FBA), the tree-length harvesting (TLH) method and the On-board intelligent biomass analyser (OBIBA) to supply sustainable, long-term and cost efficient biomass feedstock for biopower production. Moreover, it will develop the technology of the Biomass-fired Top Cycle (BTC) for a high-efficient electricity production (up to 55%). And the project will finally determine the optimal and cost-efficient CO2 capture technology for the purpose of the BTC conversion process.

To do so, EUCANwin! consortium gathers the necessary experience, knowledge and resources. It successfully works as an international cooperation, by means of 10 entities from 6 different countries, including Canada and 5 EU countries (Belgium, Finland, Hungary, Spain and Sweden), among which, 2 Canadian universities, 3 RTD organisations and 5 SMEs to ensure market exploitation (2 industrial companies and 3 innovation consultancies).
Cjelovito planiranje u modnoj industriji

The main driver of the philosophy of sustainable development were environmental problems caused by aggressive human activity to make as much money as possible. Materialism is the source of all the problems that sustainable development deals with, as well as the aspiration of every individual to own. Over time, the philosophy of sustainable development also encompassed the social effects of this behavior of society, since no development could take place without society. Finally, the question arises as to what will we leave to the generations that come after us and how will they deal with it? The fashion industry is one of the most controversial industries globally in terms of environmental impact and humanity in working conditions. The fashion industry is considered to be one of the biggest polluters of the environment. On the other hand, there is the reason why products of the fashion industry come from those parts of the world where there is no regulated labor market and labor is extremely cheap. Developing awareness of the impact of the fashion industry on today’s and the future picture of the world is necessary to change the impact on the environment and the community as a whole.
Computed Tomography Evaluation of Cardiac Valves: A Review

Electrocardiograph (ECG)-gated cardiac computed tomography (CT) angiography has great potential for the evaluation of the cardiac valves, with excellent image quality. The evidence-based, established clinical role of ECG-gated CT coronary angiography provides additional valuable information about valve morphology and function. A wide range of valve pathology, including congenital and acquired conditions, infectious endocarditis, and complications of valve replacement, can be assessed by cardiac CT imaging. Despite recent advances in CT technology, echocardiography remains the gold standard for noninvasive cardiac valve evaluation. Nevertheless, important clinical information about the valves can be obtained with coronary CT angiography examinations. Thus cardiac valve morphology and function should be routinely assessed and reported on coronary CT angiography examinations.
LEGAL SENTIENCE AND THE PROBLEM OF THE INSTANT: A CRITICAL ASSESSMENT OF THE TEMPORAL STRUCTURE OF PRECEDENT AND ITS IMPLICATIONS FOR LEGAL AUTHORITY

This paper assesses the authority of precedent from a phenomenological standpoint. Phenomenology distinguishes between two temporal models. One describes time in an idealised form, as a divisible chain of instants or events. The other looks at lived temporality as fluid and indivisible duration. In the system of precedent, we witness an interaction of both models. The legal order is constructed from slices in time that become the building blocks of future judgments. Precedents are binding for a potentially indefinite period and carry transcendental weight. But they are also entirely dependent on the occurrence of disputes in the lived world. If the law’s structural stability is to serve as a source of its authority, it is undermined by this paradox because its structure lacks the consistent input it demands. But this paper considers an alternative source of authority: the common law’s awareness of its structural shortcomings, and the mechanisms it has developed to overcome them.
Determinants of mandatory reporting: the influence of emerging markets

This research uses an instrumental variables approach to investigate the determinants of the proportion of countries with mandatory reporting by geographical area. The sample contains 62 countries grouped in 11 geographical areas. The results show that the proportion of countries with mandatory reporting depends negatively on the number of republican countries, and depends positively on the proportion of parliamentary countries, the presence of emerging markets, and the existence of pioneering countries in the field of non-financial reporting. Consequently, the presence of emerging markets in a certain geographical area appears as a key explanatory factor related to the adoption of a mandatory approach regarding reporting on non-financial information.
Effects of pulsed-radiofrequency neuromodulation on the rat with overactive bladder

To quantify the effects of pulsed radiofrequency (PRF) electrical stimulations of the pudendal and pelvic nerves on the bladder function of rats with detrusor overactivity.All rats were pretreated with a continuous transvesical infusion of 0.5% acetic acid (AA) for inducing detrusor overactivity. Intravesical pressure was recorded using cysometrography (CMG) during the continuous transvesical infusion to examine the effects of PRF electrical stimulation of the pudendal and pelvic nerves individually. In addition, the activity of caspase-3, an apoptosis marker, in the pelvic nerve was examined to evaluate the impact of PRF on nerve injury.According to the first CMG recording, AA treatment significantly reduced bladder capacity (BC) and intercontraction interval (ICI) to 65% and 66% of the corresponding control values, respectively. Subsequently, PRF electrical stimulation of the pelvic nerve inhibited AA-induced detrusor overactivity and significantly increased BC to approximately 102-110% and ICI to 79-92%; these effects persisted for at least 4 h. Furthermore, PRF did not cause significant neural damage to the target stimulated nerves, as demonstrated by caspase-3 activity.PRF electrical stimulation of pelvic nerves exerted a long-lasting effect of suppressing AA-induced detrusor overactivity. This modality can be used as an alternative approach for improving bladder continence in patients with overactive bladder syndrome.
Eidos of a city: simulating the collapse and resilience of ancient eastern mediterranean urban environments via agent-based modelling

EIDOS (EIDOS of a city: simulating the collapse and resilience of ancient Eastern Mediterranean urban environments via agent-based modelling) is an interdisciplinary project that will expand the research communities’ perception about the mechanisms that contributed to the parallel change and transformations of cities in the network of urban habitats of the Eastern Mediterranean. EIDOS will address important questions concerning the phenomenon of urbanization: why do some cities fold at the first sign of turmoil while others, seemingly similar, thrive; what are the dynamic, emergent and complex interactions between growing and deterritorialised (dying) cities within a meshwork of urban environments, from antiquity to early modern times? What components of an ancient city enabled it to be integrated and incorporated into cities of later periods, sometime spanning to our modern period? By combining historical and archaeological data with recent advances in computational simulation methods, EIDOS will significantly add to our understanding about urban resilience in the past. The training and research offered by EIDOS will position the experienced researcher (ER) as an expert in urban computational modelling with highly interdisciplinary methodologies, enabling her to significantly influence urban archaeology and contribute solid foundations to understanding the resilience of our cities.
Toward rational design of complex nanostructured liquid crystals

An analogy of block copolymer micro-segregation as a low-molecular weight nanostructured liquid crystal (LC) was tested with recently found columnar and cubic phase-forming LC molecules, to clarify the broader applicability of the analogy as a molecular design principle. We found that the copolymer analogy principle also works well for new micellar cubic phase-forming molecules. For bicontinuous cubic phase-forming 1,2-bis(4′-n-alkoxybenzoyl)hydrazines (BABH-n) compounds that cover a much broader core fraction range than that predicted by the copolymer analogy, we propose hierarchical preferential orientation as an additional mechanism for their cubic range broadening. For azo-dichiral molecules that also do not fit with the above principle, we propose chiral segregation as an alternative origin for their cubic phase formation. DOI 10.1002/tcr.201000025
METALLBEARBEITUNGSWERKSTATT ROKYTNICE

Das Projekt konzentriert sich auf die Gesamtrekonstruktion und Umwandlung eines ungenutzten, zerfallenden und technisch ungeeigneten landwirtschaftlichen Gebäudes in eine moderne Metallwerkstatt. Das Projekt wird die Kontinuität und Weiterentwicklung der Geschäftstätigkeit des Antragstellers im Bereich der Metallbearbeitung ermöglichen, da seine bestehende Niederlassung nicht mehr zufrieden stellend ist. Das Projekt wird die Produktionskapazitäten erhöhen und die Dienstleistungen des Antragstellers erhöhen, die Arbeitsbedingungen erheblich verbessern und neue qualifizierte Arbeitsplätze schaffen.
Numerical Simulation of Storage Tank Based on Control Theory of Fuzzy Rough Sets

In this paper we introduce the computer rough set theory and fuzzy control theory into the numerical simulation, and use the multimedia virtual simulation to do simulation on the heat transfer process of mechanical reserve tank, and establish 2D simulation model of tank, and add heat boundary condition in the oil tank bottom. Through the numerical simulation we obtain the curve of oil tank temperature and pressure with time. And through comparison of virtual computing results and experiment results, it verifies the reliability of the algorithm. At the end of this paper, we apply the multimedia virtual simulation technology to the basketball match, and analyze the technical parameters of the match. It provides the technical reference for the training of basketball players.
Genetic Structure ofCulex erraticusPopulations Across the Americas

Culex erraticus (Dyar & Knab) is a potential competent vector for several arboviruses such as Eastern and Venezuelan equine encephalitis viruses and West Nile virus. It therefore may play a role in the maintenance and spread of viral populations in areas of concern, including the United States where it occurs in >33 states. However, little information is available on potential barriers to movement across the species' distribution. Here, we analyze genetic variation among Cx. erraticus collected from Colombia, Guatemala, and nine locations in the United States to better understand population structure and connectivity. Comparative sequence analysis of the second internal transcribed spacer and mitochondrial NADH dehydrogenase genes identified two major lineages of sampled populations. One lineage represented the central and eastern United States, whereas the other corresponded to Central America, South America, and the western United States. Hierarchical analysis of genetic variation provided further evidence of regional population structure, although the majority of genetic variation was found to reside within populations, suggestive of large population sizes. Although significant physical barriers such as the Chihuahuan Desert probably constrain the spread of Cx. erraticus, large population sizes and connectivity within regions remain important risk factors that probably contribute to the movement of arboviruses within and between these regions.
Machining center investment and fastening system

Conmill Oy acquires a new machining centre for subcontracting. The project supports the company’s competitiveness to meet current demand. The company will acquire a new machining centre in the current financial year. The company’s goal is to grow and automate operations. The share of exports in the company’s turnover increases with the investment.