SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
The relationship between estrogen receptors and microtubule dynamics in post-menopausal rat brain

Estrogen is one of the most important regulators of neuron function. There is a broad consensus that a loss of estrogen is associated with neurodegeneration in the hippocampus which leads to cognitive impairment. Hematopoietic-Pbx-interaction-protein (HPIP) is a novel scaffolding protein which interacts with microtubules and estrogen receptors. In this study, we investigated the presence and role of HPIP in hippocampal neurons and examined the relationship between estrogen receptors and microtubule damage in post-menopausal rat brains.Eighty female Wistar albino rats, 12 weeks old, were divided into 10 groups: control, control+17-β-estradiol, control+tamoxifen, control+mitogen-activated protein kinases (MAPK) inhibitor, control+phosphoinositide 3-kinase (PI3-K) inhibitor, ovariectomized, ovariectomized+17-β-estradiol, ovariectomized+tamoxifen, ovariectomized+MAPK inhibitor, and ovariectomized+PI3-K inhibitor. Light and electron microscopic examinations were performed. Real-time polymerase chain reaction (PCR) was used to determine the expression level of HPIP in experimental groups.Light and electron microscopic examinations revealed morphological changes in hippocampal neuron axons. Axonal fluctuations and shrinkage were detected in all ovariectomized groups. HPIP was detected in all neurons with difference expression levels.Proof that the HPIP protein can be found on hippocampal neurons may give rise to a new focus on neurodegeneration in post-menopausal women. Future molecular and pharmacological studies should be performed to reduce the rate of cognitive symptoms resulting from hippocampal neurodegeneration.
Cellular and genetic bases of neural circuits evolution

Sensory systems encode the world around us to produce context-dependent appropriate behaviours. However, we know little about the way new sensory evoked behaviours arise as neural circuits are re-shaped during evolution. Tackling this question requires a deep understanding of the circuits underlying specific behaviours and integration of this knowledge with tools from other fields, including evolutionary and developmental biology. Recent technological advancements on neural circuit interrogation and genome editing have put progress on this fundamental biological question within reach. 
The olfactory system of the larval stage of the fly Drosophila melanogaster and related species is an ideal model for investigating these questions because (i) D. melanogaster has pioneered both the fields of population genetics and neurogenetics and (ii) its olfactory system is one of the best-characterised neural circuits. We will address the question of how olfactory circuits evolve by studying four species with divergent odour-guided behaviours through the following multidisciplinary aims:
1. Which olfactory pathways are targeted in the evolution of ecological specialisation? – Combining high-throughput behavioural assays, optogenetics and calcium imaging in the larva of all four species we will determine whether/which olfactory pathways have switched valences or sensitivity.
2. How have central neural circuits diverged? – We will address this question at unprecedented resolution through whole-brain calcium imaging and serial electron microscopy reconstruction.
3. What are the molecular and genetic bases of neural circuits rewiring during evolution? – Using transcriptomic profiling we will identify differentially expressed genes in conserved and divergent circuits across species, and functionally probe selected candidates to establish causality.
4. How do evolutionary forces shape olfactory circuits? – We will investigate this question using field studies and population genetics
Mitotic scaling to cell size diversity during vertebrate embryonic development

Cell division is a common process to all cell types in a multicellular organism. During mitosis, equal chromosome segregation in anaphase is regulated by an Aurora B phosphorylation gradient, centered at the midplane between the two chromosome sets. The gradient gives positional information that allows nuclear envelope reformation (NER) only when chromosomes are far enough from the kinase activity. Considering the 120μm human zygote and a 15μm fibroblast, how can the gradient scale with cell size over such wide range of sizes? 
To unravel the scaling mechanism, I will measure the biophysical parameters of this phosphorylation gradient using a FRET sensor and optogenetics to manipulate the gradient with fast spatiotemporal kinetics. I will address three key questions: 
i) Does the gradient sense cell size? ii) If so, how is size information used to scale the gradient? iii) How is gradient scaling translated into NER positioning? 
I will focus on three zebrafish cell systems with extreme sizes and dynamics: 1) embryonic cleavage divisions, where cell size halves with every cell division; 2) EVL cells, which are stretched quickly into flatter cell sizes, implying fast scaling dynamics; 3) asymmetric division in neuronal precursor cells, where the two sides of the spindle midzone must scale differently to generate daughters of different sizes. With this approach, I will generate unprecedented information on the regulation of anaphase chromosome separation in its natural context. This entry point in anaphase will provide a conceptual frame and a tool kit to address a more general problem: how do other mitotic machineries scale with cell size? A wider question for my long-term future research.
DOOR FOR A GARAGE, HALL, AND THE LIKE, COMPRISING A CLOSURE SYSTEM FOR OPENING AND CLOSING THE DOOR OPENING

The invention relates to a door for a garage, hall, and the like, comprising a closure system for opening and closing the door opening by means of lamellae which can be vertically moved in the opening by at least one drive train and which close the opening when arranged one over the other, wherein at the lowest position of each lamellae during a lowering process for opening the door, the lamellae can be transferred into a floor storage area, which is preferably arranged underground, transversely to the lowering direction, in particular perpendicularly to the lowering direction, in the floor region.
LOCK DEVICE AND APPARATUS MOUNTED WITH THE SAME

The present invention relates to a lock device, comprising a housing including a lock hook (110) mounted in the housing, the lock hook (110) pivotally moves to and away from a lock hook locked position; a locking slider (130) for locking the lock hook (110), the locking slider (130) having a locking slider first end (131a) which abuts against an axial surface (111) of the lock hook, the locking slider is reciprocatingly slideable in a first direction parallel to the lock hook pivoting plane following pivoting of the lock hook to move to or away from a locking slider locked position; a slider locking device (150) for locking the locking slider (130), the slider locking device (150) is reciprocating slideable in a second direction following the reciprocatingly sliding of the locking slider (130) in the first direction, the second direction crosses the lock hook pivoting plane. The present invention further relates to an apparatus mounted with said lock device.
DEFOAMING COMPOSITIONS COMPRISING AMPHIPHILIC PARTICLES AND METHODS OF MAKING AND USING THE SAME

Disclosed herein are methods of defoaming industrial process streams, the methods comprising adding to the industrial process stream an emulsion stabilized by amphiphilic particles, wherein the amphiphilic particles comprise at least one hydrophobic surface and at least one hydrophilic surface, and wherein the emulsion comprises silicone emulsion droplets in a continuous aqueous phase. Also disclosed herein are defoamer compositions comprising amphiphilic particles and methods of making such compositions.
Nuevas estrategias para la visualización y difusión del patrimonio descontextualizado. El caso de la sillería de la catedral de Oviedo

Partiendo del caso de la sillería del coro de la catedral de Oviedo, desmantelada y reconstruida parcialmente en la sala Capitular del mismo edificio, este artículo describe el proceso de reconstrucción virtual y posterior visualización interactiva del conjunto original en su contexto. Para ello se integran geométricamente imágenes equirectangulares del edificio actual con el modelo virtual de la sillería reconstruida en su totalidad a partir del levantamiento fotogramétrico de parte de ella, todavía existente. La técnica permite combinar de forma hiperrealista imágenes reales y virtuales, ofreciendo al espectador, de forma interactiva e inmersiva, un recorrido virtual “mixto” de la nave central de la catedral que incorpora el modelo virtual reconstruido en la ubicación para el que fue originalmente diseñado. La metodología propuesta supone una nueva estrategia de visualización que, de forma económica, interactiva, ubicua y universal, ha de permitir un avance en la difusión del patrimonio descontextualizado.
Optimized process of metal assisted silicon wet etching for antireflection layer

In this study, a simple fabrication technique for silicon (Si) subwavelength structure (SWS) by means of chemical wet etching using Au nano particles directly formed on silicon substrates was proposed and optimized. Single nano-sized Au particles were fabricated using the metal self-aggregation effect. The deposition and thermal annealing of the metallic thin film were undertaken. The thermal annealing of the metallic thin film enables the creation of metal nano particles by isolating them from each other through the self-aggregation of the metal. It was found that the initial Au film thickness can affect the particle size and change the etching conditions such as the fill factor, inter-particle distance, and so on. Then, samples were soaked in an aqueous etching solution of hydrofluoric acid and hydrogen peroxide. When using the optimized process parameters, although Si etching was only 2min in duration, the reflectance decreased to approximately 1% in the whole wavelength range from 300 to 1300nm due to the deep and steep double tapered structure.
Effects of gender roles, child wish motives, subjective well-being, and marital adjustment on infertility-related stress: a preliminary study with a Hungarian sample of involuntary childless men and women

The aim of the study is to investigate the infertility-related stress in a Hungarian infertile population and examine the effects of gender roles, child wish motives, subjective well-being, and marital relationship on the experience of infertility according to our self-constructed conceptual framework.Validated self-report questionnaires measuring the factors of the conceptual framework were taken in the study carried out in a sample of 53 people attending the fertility unit of a Hungarian clinic.Infertility-related global stress, infertility-related social concerns, and general health problems have more intensive effect on women than on men (all p < 0.05). Women from the infertile group scored higher their femininity (p < 0.001) and lower their general health (p < 0.05) than the reference population. Infertile men believe deeper in meaning of life than women (p < 0.05) or reference population (p < 0.01). Femininity (β = 0.460, p < 0.05), traditional gender role concepts (β = -0.248, p < 0.05), general health (β = -0.474, p < 0.05), and marital relationship (β = -0.251, p < 0.05) play the strongest role to predict stress caused by infertility.The current study emphasizes the importance of interrelations of gender role attitudes, gender role identification, general health, and satisfaction in couple relationship with infertility-related stress. In further investigations, both social and personal aspects and their effect on experiencing infertility need to be measured in infertile people, particularly in different cultural settings.
VISCOUS CLUTCH AND ASSOCIATED RESERVOIR CONFIGURATION

A viscous clutch (30; 130; 230) includes a shaft (32; 132; 232), a rotor (34; 134; 234) attached to the shaft, a housing (36; 136; 236) located adjacent to the rotor, a working chamber (40; 140; 240) defined between the rotor and the housing, and a reservoir (38; 138; 238) used to store a shear fluid. Selective introduction of the shear fluid to the working chamber facilitates selective torque transmission between the rotor and the housing. The reservoir is attached to the shaft separately from the rotor.
Business co-operation one-stop shop

B-CROSS project aims are the development of a Business Cooperation Network among Chambers of Commerce and Industry in CADSES and other INTERREG III B co-operation areas, that will use a Business Cooperation One Stop Shop (B-CROSS) to support and enforce Business Cooperation among SMEs in the involved countries. B-CROSS takes advantage of the existing experience and special know-how on ICT technology, ICT services offered by Chambers and Business Cooperation available in the partnership. B-CROSS includes mechanisms for connecting to different Chamber ICT systems where the existing business digital content is available. Other special services that will be developed will include services for the presentation of the regional characteristics and offered opportunities, user friendly tools to help SMEs create small product and company profiles, integrated transnational business catalogues and yellow pages, synchronous and asynchronous collaboration tools, and training services, among others. B-CROSS works as the tool to promote market opportunities, and match Offer- Demand of Products and Services to support SMEs towards business cooperation. During the course of the project the CCI network that will be developed, will include experts from other Chambers or related business efforts, so B-CROSS will be easily expanded with the entrance of new regions, (through the respective Chambers, SMEs Associations), and new applications. The large investment after the end of the project will be studied in the Business plan that the B-CROSS CCI network will publish.
Introducing silicone to the world of additive manufacturing

Additive Manufacturing (AM) is a well-known technology for materializing rigid objects from plastics, metals or ceramics; but when it comes to soft materials, like silicone, the technology has not yet reached its maturity. At Spectroplast, our startup from the Switzerland’s Federal Institute of Technology, we developed a cutting-edge technology enabling the additive manufacturing of silicones to produce soft elastomeric components suitable for industrial and life-saving medical applications. Our value proposition revolves around: the first high-precision silicone AM platform, compatibility of our process with any industrial/off-the-shelf silicone, ISO-certified components (10993-5, 10993-10), time and cost-effectiveness due to direct fabrication, process working on low energy consumption and Zero-waste, development of tailor-made elastomeric 3D printing materials. With no similar commercially available solution on the market, our technology can serve as the perfect complementary technique for industrial-scale productions, moving from mass production to mass customization and going beyond the prototyping level. Spectroplast represents a radical innovative solution with the potential of disrupting the current silicone components’ production’s state-of-the-art and opening-up new markets, represented by the growing number of industry verticals in need of soft, functional and customized products. Currently, our solution is at TRL6 and we aim to scale it up to TRL9 to commercialize an industrial-scale silicone AM platform with top performance ratings from end-users and stakeholders by 2021. By applying to Phase 1 SME Instrument, we aim to carry out a feasibility study to verify the technical, commercial and financial viability of our solution and develop a business plan to drive its successful market uptake. Indeed, according to our realistic trading projections we will achieve approx. €12M total revenues by the 5th year (ROI = 3).
Subvention du fonds de roulement pour «MC DIAM» sp. z o.o.

Le projet concerne le soutien de l’entrepreneur à fournir des liquidités financières et à soutenir les activités en cours en raison des difficultés financières rencontrées par l’entrepreneur à la suite de la pandémie de COVID-19. Assistance financière fournie au titre du programme SA.57015 (2020/N)
MULTIPART LABEL LAMINATE, LABELS AND LABELLING

The invention relates to a multipart label laminate for labelling of single-use sterilization packs, the multipart label laminate comprising a face layer, a first adhesive layer of acrylic based pressure sensitive adhesive, a carrier, a second adhesive layer of acrylic based pressure sensitive adhesive, a liner, and a printing ink layer between the carrier and the second adhesive layer. The invention further relates to a method for application of a multipart label.
Flexible tooling design technology for aircraft fuselage panel component pre-assembly

Purpose – The purpose of this paper is to develop digital flexible pre-assembly tooling system for fuselage panels. Design/methodology/approach – First, the paper analyzes the technological characteristics of fuselage panels and then determines the pre-assembly object. Second, the pre-assembly positioning method and assembly process are researched. Third, the panel components pre-assembly flexible tooling scheme is constructed. Finally, the pre-assembly flexible tooling system is designed and manufactured. Findings – This study shows the novel solution results in significantly smaller tooling dimensions, while providing greater stability. Digital flexible assembly is an effective way to reduce floor space, reduce delivery and production lead times and improve quality. Practical implications – The tooling designed in this case is actually used in industrial application. The flexible tooling can realize the pre-assembly for a number of fuselage panels, which is shown as an example in this paper. Originality/value – The paper suggests the fuselage panel pre-assembly process based on the thought including pre-assembly, the automatic drilling and riveting and jointing, and constructs a flexible tooling system for aircraft fuselage panel component pre-assembly.
Mapping the lithosphere and asthenosphere with surface waves: Lateral structure and anisotropy

A review of the basic theory and practice of mapping lateral variations in surface wave phase velocities is presented, with some examples from the work of Ekstrom et al. [1997]. The importance of crustal corrections is demonstrated by comparison of observed phase velocities with those calculated from the recent crustal model of Mooney et al. [1998]. Phase velocity maps including terms of azimuthal anisotropy are presented, and an experiment suggests that in areas of poor path coverage, a bias is introduced when azimuthal effects are neglected in the inversion. The inversion procedure for obtaining a model of three-dimensional velocity heterogeneity in the mantle from surface wave dispersion data is discussed in the context of the new mantle model S20A [Ekstrom and Dziewonski, 1998]. This model exhibits significant lateral variations in radial anisotropy in the top 200-300 km of the mantle, resulting from the incompatibility of Rayleigh and Love wave dispersion data. This result suggests an important new direction for tomographic imaging of the upper mantle.
Synthesis and electrochemistry of some ferrocenyl substituted dicarba- and tricarbaborane compounds

Treatment of arachno-4-Me(2)S-B(9)H(13) (1) with ethynylferrocene, FcC[triple bond]CH (Fc = ferrocenyl), in boiling benzene afforded an inseparable 2 : 1 mixture of 6-Fc-nido-5,6-C(2)B(8)H(11) (2a) and 5-Fc-nido-5,6-C(2)B(8)H(11) (2b) in a 10% yield. However, compound 2b was converted quantitatively to the pure, violet 2a by the action of proton sponge (PS), followed by acidification. The structure of 2a was determined by X-ray diffraction analysis. Heating of 2a at 400 degrees C led to the dehydrogenation and isolation of the orange 1-Fc-closo-1,10-C(2)B(8)H(9) (3) in almost quantitative yield, while treatment of 2a with t-BuNC and PS (proton sponge = 1,8-bis(dimethylamino)naphthalene) in CH(2)Cl(2) generated the neutral absolute tautomer 7-t-BuNH-8-Fc-7,8,9-C(3)B(8)H(10) (N4) (yield 50%), which could be converted quantitatively into the zwitterionic tautomer 7-t-BuNH(2)-8-Fc-7,8,9-C(3)B(8)H(9) (Z4) via dissolution in MeCN. Tautomers N4 and Z4 sharply differ in NMR properties and both gave rise to a pair of cage-isomeric closo ferratricarbollides, [1-Cp-2-Fc-12-t-BuNH-1,2,4,12-FeC(3)B(8)H(9)] (5a) (Cp = eta(5)-C(5)H(5)) (yield 48%) and [1-Cp-2-Fc-10-t-BuNH-1,2,4,10-FeC(3)B(8)H(9)] (5b) (yield 32%), upon heating with [CpFe(CO)(2)](2) in mesitylene at reflux. Electrochemical studies revealed that the compounds display one (compounds 2a and 3) or two (compounds 5a and 5b) well-defined, reversible one-electron Fe(II)/Fe(III) redox changes.
Test bed for low-cost measurement of AM/AM and AM/PM effects in RF PAs based on FPGA

This work presents a new proposal FPGA-based for low cost measurement of AM/AM and AM-PM distortion curves in RF Power Amplifiers through DSP Builder tool into a Development Board. A practical comparison between state-of-the-art reported works based on measurements of AM/AM and AM-PM distortion curves is discussed, in terms of low cost measurement, by using a FPGA development board and a PC to obtain the PA distortion curves adding flexibility to read the PA behavior. The main contribution is the full control of the digital PA behavior based on the phase to amplitude conversion principle simulated in Matlab-Simulink. This test bed is able to recalculate the known AM/AM and AM/PM measurements stored as LUT in a previous development board but also a real PA as DUT can be added.
EUROPEAN NETWORK FOR THE SHARING AND DISSEMINATION OF TECHNOLOGIES AND KNOWLEDGE IN THE INNOVATIVE FIELD OF GAME BASED LEARNING

Primary objective of LUDUS (in Latin, game) proposed project is the creation of a South Eastern European network for the transfer of knowledge and dissemination of best practices in the innovative field of Serious Games. Serious games are electronic games designed primarily for learning (or even advertising, simulation, etc) instead of pure entertainment. Serious game must be entertaining, but this fun element serves a learning purpose. Nine competent institutions (two Universities, three regional innovation centres, one non profit organisation and three social partners) from seven European countries cooperate within LUDUS. The proposed activities aim to promote awareness, networking, sharing of knowledge and of experiences, as well as to develop skills and competencies in Serious Games development and use. Activities include: state of the art and field analysis, survey on the readiness/interest/views of IT companies, educational institutions, local development organisations in serious gaming, training and networking workshops and events, European conferences, European competitions, open training labs, an online knowledge node with database of experts, stakeholders, forum, wikis, blogs, news, events and resources on serious games, project website, promotion actions and Best Practices Guide. The activities take place in all seven participating countries, creating a live network of interactions, involving all partners, regional stakeholders and external experts.