SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Pitx2 and Pitx3 transcription factors: two key regulators of the redox state in adult skeletal muscle stem cells and muscle regeneration

Adult tissue homeostasis and regeneration rely on tissue stem cell populations that generate committed precursors and differentiated cells while maintaining a pool of stem cells. In adult skeletal muscle, such cells, called satellite cells, remain quiescent at the periphery of muscle fibers. Upon injury they undergo activation, proliferation and differentiation to replace damaged fibers and also self-renew to reconstitute the muscle stem cell pool. During regeneration, the transition from a quiescent muscle stem cell to a differentiated fiber is accompanied by major metabolic changes. Such changes, and notably the switch from a glycolytic proliferative progenitor state to an oxidative post-mitotic differentiated state, require extensive mitochondrial biogenesis that takes place at the onset of differentiation and leads to increased ROS production. However, it is unclear whether this enhanced ROS production/mitochondrial content reflects an adaptation to the rising energy demand or whether it constitutes an essential regulation element of the differentiation program.To investigate the potential role of this metabolic switch and more specifically of reactive oxygen species during muscle regeneration, we took advantage of mouse mutants for Pitx2 and Pitx3 genes. Both genes are involved in foetal myogenesis where they have been identified as key regulators of the redox state preventing excessive ROS levels and DNA damage as cells undergo differentiation. We have now analyzed adult single and double Pitx2:Pitx3 conditional mutant mouse lines targeted to the muscle stem cell compartment. Double mutant satellite cells undergo senescence with impaired regeneration after injury, whereas in single Pitx3 mutants, premature differentiation occurs. We show that these effects are directly linked to dose-dependent changes in ROS levels and can be reversed by lowering ROS with the N-acetylcystein, supporting the notion that a controlled increase in ROS is required for differentiation of muscle stem cells.
Imminocytochemical study of secretion by the mouse subcommissural organ after captopril treatment

We have studied the effects of chronic treatment with captopril (angiotensin-converting enzyme inhibitor, ACEI) on the secretion of the subcorn­ missural organ (SCO) of the adult male mouse using immunohistochemistry for AFRU (antibody anti-Reissner's fiber, Rodriguez et al., 1994). Three groups of 5 animals each -a control group and 2 experimental groups- were used. The experimental groups received captopril in their drinking water frorn postnatal day 55 at adose of 1 mg!kg body weight in experimental group 1 (CAP-1), and 4 mg!kg body weight in experimental group 11(CAP-4). Captopril adrninistration at adose of 1 mg!kg did not alter the amount of AFRU immunoreactive material (AFRU-ir) in the SCO, but captopril administration at adose of 4 mg!kg elicited a significant decrease in the SCO AFRU-ir material.
MACHINE A LAVER LE LINGE ETROITE ET ENCASTRABLE

<P>MACHINE A LAVER LE LINGE ETROITE, A CHARGEMENT PAR LE HAUT.</P><P>SELON L'INVENTION, UNE MACHINE A LAVER A CHARGEMENT PAR LE HAUT, TOUT EN ETANT ETROITE, EST ENCASTRABLE SOUS UN PLAN DE TRAVAIL NORMALISE A 85CM DE HAUTEUR ET 3CM D'EPAISSEUR GRACE A UN AGENCEMENT PARTICULIER, DANS LA CARCASSE 3, DES DIFFERENTS ORGANES NECESSAIRES AU FONCTIONNEMENT DE LA MACHINE ET NOTAMMENT DE LA CUVE 20 ET DE SES MOYENS DE SUSPENSION 23, 24, CET AGENCEMENT ETANT TEL QUE LA HAUTEUR TOTALE DE LA MACHINE EST LEGEREMENT INFERIEURE OU EGALE A 82CM TANDIS QUE SA PROFONDEUR EST INFERIEURE A 60CM ET PAR EXEMPLE DE L'ORDRE DE 57CM.</P>
Evaluation of 22 nm fully-depleted silicon-on-insulator technology for space

The EFESOS project aims to develop and evaluate a cutting-edge ASIC technology for space applications. More specifically, departing from the characterization of the commercial technology, a radiation-hardened-by-design digital library and a set of complex analog IP cores (ADC, DAC, SERDES and PLL) will be implemented using the 22FDX process from Global Foundries, available at their production facility in Dresden (Germany). A complete electrical, environmental (radiation) and reliability validation of the technology will be performed, and the resulting fully-European design flow will be evaluated according to the ESCC standards with a representative sample chip.
The 22FDX is a 22nm Fully-Depleted SOI technology providing up to 40% die scaling relative to the standard 28nm node, nearly 70% lower power than 28nm and similar power efficiency to FinFET technology.
EFESOS responds to the increasing demand of the European space industry of more integrated ASICs at higher performance, and greatly contributes to the strategic goal of achieving non-dependence on critical technologies. The project will provide Europe with a technical capability beyond the current state-of-the-art, thus becoming a global reference in space microelectronics.
Information sources used by Gram Panchayat members for agricultural development.

In the beginning of the 21 st century a global development taking place and India is supported to keep pace with it, farmers all over country are supported by the State Govt. through various development schemes. Leaders in the villages i.e . Gram Panchayat members use many other sources for agricultural development.The study was undertaken in the year 2012-13. A sample of 120 GramPanchayat members was randomly selected in 10 villages of Amravati Panchayat Samiti of Amravati District of Maharashtra. Majority (61.67%) of members had medium level of use of information source. Among the selected characteristics, education, land holding, occupation, annual income, social participation, cosmopoliteness, agricultural progressiveness, extension contact and knowledge were positive and significantly related with use of information source where as age was non-significant with use of information source.
YOUTH EMPLOYMENT IN PORTS OF THE MEDITERRANEAN

Ports connected to international trade, environment and sustainability, digitization, port logistics and transport networks are currently one of the main focuses of job creation in the Blue Economy sector. Additionally, the ports ecosystem has a high concentration of companies that are usually bigger than in other sectors, allowing for a greater jobs absorption capacity. This potential could be better exploited through dedicated dual Technical and Vocational Education and Training (TVET) with job-oriented placement schemes addressing NEETs in the Mediterranean region. Facing this challenge, YEP MED proposes to enrich the TVET by developing three main areas with skills shortages: foreign trade, environment and sustainability, digitization and port logistic operations. The project will develop port-logistics TVET resources adapted to the sector needs, launch learning programmes with job placement programmes and set up partnerships between key stakeholders in the 7 involved countries. YEP MED will adapt 9 training curricula to the actual needs of the productive sectors, introducing personalized monitoring to students and creating training courses that address environmental issues.
The neutron electric dipole moment: pushing the precision to understand the matter-antimatter asymmetry

The existence of a permanent electric dipole moment (EDM) of the neutron, or any subatomic particle, would have far reaching implications connecting particle physics with cosmology. Time reversal invariance and CP symmetry would be violated. A new fundamental interaction producing the EDM, that is, deforming the charge distribution inside the neutron, could also have generated the matter-antimatter asymmetry in the early Universe. After 60 years of evolution, techniques to measure the neutron EDM are now so evolved that experiments are sensitive to microphysics associated with an energy scale beyond that accessible at the LHC. This situation offers a high likelihood of discovery for the next generation of experiments. In the same time, any improvement in precision is technically challenging. The control of the magnetic field must surpass that of the state of the art of atomic magnetometers. The n2EDM project aims at improving the precision by an order of magnitude or more. Systematic effects need to be controlled at an unprecedented level. In particular, the use of a mercury co-magnetometer based on the precession of 199Hg spins induces a set of subtle false effects due to the relativistic motional field. 
I propose to initiate a comprehensive program to master these systematic effects beyond the current research program. In particular, the proposed project includes a precise determination of the 199Hg magnetic moment with a precision of 0.1 ppm. To this end, I will attempt a novel approach: combining mercury and 4He magnetometry in the same cell. As a by-product, this will also produce an improved determination of the neutron magnetic moment, a quantity of interest for metrology. The cross-check I propose will prove that all disturbances on the neutron or mercury spins are mastered at the sub-ppm level, a decisive step in the quest for the neutron EDM.
Isolation and pathogenicity of Colletotrichum spp. causing anthracnose of Indian mulberry (Morinda citrifolia) in tropical islands of Andaman and Nicobar, India

This study identifies the Colletotrichum spp. which cause Morinda anthracnose in the Andaman and Nicobar Islands, India. A survey of Indian mulberry plantations was carried out to ascertain the identity of isolates associated with Morinda anthracnose. These were identified as C. gloeosporioides based on morphology and sequencing analysis of internal transcribed spacer (ITS) region, demonstrating that this species is currently the causal agent of Morinda anthracnose in a tropical ecosystem. The pathogenicity test of C. gloeosporioides isolates on Morinda seedlings for 1 month revealed that the five isolates MC1, MC8, MC2 (1), MC4 and MC12 were pathogenic to the respective host with different levels of anthracnose lesion.
Self-Control and Lifestyles: Associations to Juvenile Offending, Violent Victimization, and Witnessing Violence

AbstractThe extent to which well-established theories of offending apply to violent victimization is increasingly studied. Measures of indirect victimization are rarely included in this literature. This study examined the concurrent relation of self-control components and lifestyle measures to juvenile offending, direct victimization, and witnessing violence among 233 Hispanic and African American 11th-grade students. Findings revealed strong support for the role of a deviant lifestyle; support for prosocial lifestyle effects was weaker. Support for the applicability of the general theory of crime was more mixed compared to lifestyle theory because findings revealed high specificity in variable associations for individual components of self-control.
PERMANENT PLASTIC FORMWORK SYSTEM

The invention relates to a permanent plastic formwork system formed by two parallel surfaces, namely an outer surface (1) and an inner surface (2), consisting of a plurality of flat or longitudinally curved, hollow, extruded plastic slats (4) provided internally with metal stiffening sections (13) and joined longitudinally by tongued-and-grooved ends (4a and 4b), separators (5) being disposed between the two surfaces. Said separators are provided with a threaded zone (6) and an inclined appendage (8) for securing the rebar mesh (3) located between the surfaces. The slats (4) are secured to the ground using U-shaped parts (9) containing a threaded rod (10) that can be used to clamp and attach same. In addition, in closed structures diagonal reinforced internal elements can be incorporated, such as metal bars (11) with flat end surfaces (12) enabling same to be secured to the above-mentioned inner surface (2).
Investigating the functional impact of neurodegeneration-causing rare variants in the teleost model zebrafish

Circa 30 million people in Europe suffer from life-threatening rare diseases, which are poorly understood. This major societal burden forces patients into endless paths for a diagnosis often without cure. EU cooperation efforts between countries contribute to improve research and visibility of these diseases with a primary role of the ‘Ospedale pediatrico Bambino Gesù’ (OPBG, Italy). Here, via next generation sequencing technology, Dr. Tartaglia recently described new genetic variants, including some in the tubulin cofactors TBCE and TBCD which alter microtubules (MTs) dynamics (crucial for brain development and maintenance) and cause previously undescribed early onset neurodegeneration. Yet the underlying pathogenic mechanisms and impact on the brain physiology remain elusive. Given the difficulty to reproduce brain physiology in vitro and its general inaccessibility, a vertebrate model amenable to genetic and whole-brain in vivo investigation is necessary. With its rapid and transparent development and genetic and imaging tools improving continuously, the small teleost fish zebrafish is ideal. I will monitor live MTs behaviour and cellular processes (e.g. cell division, axons formation and innervation) in the precursor and mature neurons of zebrafish TBCE and TBCD mutants, focusing on motoneurons. To this aim, I will combine my expertise in fish neurobiology with the host’skills in human genetics (Dr. Tartaglia) and fish gene editing (Dr. Del Bene, France). In line with the current EU efforts, this work will advance our understanding on rare genetic variants causing neurodegeneration. Deciphering the role of MTs dynamics on brain physiology will be relevant also for common brain disorders and exome sequencing of undiagnosed patients will further contribute to a genotype-phenotype catalog. Via an intensive transfer of knowledge, the project will increase EU multi-disciplinary competence on rare disorders in general, providing new models for therapy development.
Surface functionalized-mos2 nanofluids as high temperature lubricant additives

There is an increasing and urgent need in Europe and globally for effective and robust high temperature (HT) lubricant additives in critical industrial applications. Combining synergistically the exceptional oil solubility of organic polymers and the excellent tribological behaviour of MoS2 nanoparticles (NPs), polymer functionalized-MoS2 NPs with good dispersion stability will be designed and synthesized as candidates for HT lubricant additives. In addition, to suppress MoS2 oxidation under HT, which would cause high friction and wear, carbon nanomaterials (CNMs) will be covalently combined with MoS2 NPs to improve the retention of MoS2 on the frictional surfaces and prevent oxidation during rubbing. In this project, MoS2 NPs will be functionalized by two methods: 1) Immobilization of organic polymer on the surface of MoS2 NPs using non-covalent and covalent approaches. The organic polymers including oil-soluble poly-(lauryl methacrylate) (PLMA), polyalkylene glycol (PEG), and hyperbranched poly(3-ethyl-3-hydroxymethyloxetane) PEHO; 2) MoS2 NPs growing on the surface of organic polymer modified-CNMs with covalent bonds. The polymers connecting CNMs and MoS2 NPs are novel PEHO and PEG derivatives with lipoic acid (LA) and nitrilotriacetic acid (NTA) terminals. The properties of the grafted polymers on MoS2 NPs and CNMs will be analyzed. The dispersion stability of surface functionalization MoS2 NPs will be assessed by SAXS/SANS, as well as cryo-TEM, SEM, DLS, and ξ- potential measurements. The surface force apparatus (SFA) will be used for mechanistic understanding of how such NPs mediate friction, with the macroscopic HT tribological properties of the NP dispersions investigated using tribometer. The correlation between the NP physicochemical properties and their efficacy in lubrication will be assessed. The wear mechanism of surface functionalized-MoS2 NPs as friction reduction and antiwear (AW) additives in lubricating oils will be explored by XPS and SEM-EDS.
WD REPEAT 79 PROTEIN TARGETED THERAPY

Methods and compositions are disclosed for inhibiting cell proliferation and diagnosing and treating cancer comprising antagonists or inhibitors of the WDR79 protein. Also disclosed are methods for screening compounds for WDR79 inhibitory or antagonist activity.
Disease relevance of phosphorylated ubiquitin (p-S65-Ub)

Here, we present a summary of our recent findings on the (patho-)physiological relevance of PINK1-phosphorylated ubiquitin (p-S65-Ub). Using novel polyclonal antibodies, we find that p-S65-Ub specifically accumulates on damaged mitochondria. Phosphorylation of ubiquitin on serine 65 depends on the activity of PINK1 and the signal is vastly amplified by the activity of the E3 ubiquitin ligase PARK2/Parkin in a feed-forward loop. The induction of p-S65-Ub in primary cells suggests a significant role of p-S65-Ub also in neurons. Consistent with a marker for damaged mitochondria that are undergoing mitophagy, we find anti-p-S65-Ub immunoreactive granules that partially colocalize with mitochondria, lysosomes and ubiquitin in human post-mortem brain. The number of p-S65-Ub positive granules increases with age and with PD, highlighting the relevance of p-S65-Ub as a potential biomarker and therapeutic target.
Vulnerabilities under the global protection regime: how does the law assess, address, shape, and produce the vulnerabilities of protection seekers?

‘Vulnerability’ is increasingly used as a conceptual tool to guide the design and implementation of the global protection regime, as illustrated by the 2016 New York Declaration for Refugees and Migrants and the subsequent adoption of the Global Compact for Safe, Orderly and Regular Migration and of the final draft of the Global Compact on Refugees. However, ‘vulnerability’ lacks a sharp conceptualisation and still needs to be accompanied by a thorough understanding of its concrete meanings, practical consequences and legal implications. This research project aims to address these uncertainties from a critical and comparative perspective, with a focus on forced migration. It will provide a comprehensive analysis of how the ‘protection regimes’ of select countries address the vulnerabilities of ‘protection seekers’. The select countries are in Europe (Belgium, Germany, Italy, Norway), North America (Canada), the Middle East (Lebanon) and Africa (Uganda and South Africa). The analysis adopts two different yet complementary perspectives. First, the way the ‘vulnerabilities’ of the protection seekers are being assessed and addressed by the relevant norms and in the practices of the decision makers will be systematically documented and analysed through a combination of legal and empirical data. Second, the various forms and nature of the concrete experiences of ‘vulnerability’ as they are lived by the protection seekers, including the resilience strategies and how they are being continuously shaped in interactions with the legal frameworks, will be documented and analysed through empirical data collected during fieldwork research. Ultimately, the very notion of ‘vulnerability’ will be questioned and assessed from a critical perspective. An alternative concept, such as ‘precarity’, may be suggested to better reflect the concrete experiences of the protection seekers.
New methods in mixture analysis

The quest for a complete understanding of mixtures
is a challenge which has stimulated the development of several
techniques. One of the most powerful NMR-based techniques is known
as Diffusion-Ordered SpectroscopY (DOSY), in which it is possible
to distinguish the NMR spectra of chemical species with different
hydrodynamic radii, i.e. with different self-diffusion
coefficients. It allows the study of intact mixtures, providing
information on the interactions within the mixture and saving time
and money compared to other techniques. Unfortunately, DOSY is not
very effective when signals overlap and/or the diffusion
coefficients are very similar. This drawback has led to the
development of new methods to overcome this problem. The present
investigation is focused on developing some of these.Most DOSY
datasets show multiplet phase distortions caused by J-modulation.
These distortions not only hinder the interpretation of spectra,
but also increase the overlap between signals. The addition of a
45o purging pulse immediately before the onset of acquisition is
proposed as a way to remove the unwanted distortions.Most DOSY
experiments use 1H detection, because of the higher sensitivity
which is generally achieved. However, acquiring spectra with other
nuclei such as 13C can reduce overlap problems. Two new sequences
have been developed to maximize the sensitivity of heteronuclear
DOSY experiments.In order to increase resolving power, it is also
possible to incorporate another variable into diffusion experiments
as a further dimension. If this results in an approximately
trilinear dataset (each dimension varying independently), it is
possible to extract physically meaningful information for each
component using multivariate statistical methods. This is explored
for the cases where the new variable is either the relaxation
behaviour or the concentration variation (which can be measured
during a reaction or in a set of samples with different
concentrations for each component). PARAllel FACtor (PARAFAC)
analysis can obtain the spectra, diffusional decay and relaxation
evolution or kinetics for each of the components.In a completely
different approach, the separation power of liquid chromatography
has been combined in a novel way with the NMR potential for
elucidating structures. NMR has been used previously as a precise
way to measure average flow velocities, even in porous media. Using
this capability to detect the different average velocities of
solutes that occur in chromatographic columns ought to provide a
new way of analysing mixtures with the same potential as LC-NMR,
but faster and more simple. In such a flow system, a
chromatographic column is introduced into the NMR probe and a 2D
dataset is acquired and Fourier transformed to obtain the velocity
distribution for each of the detected NMR signals.
On the Establishment of Xinjiang Province and the Social Changes in Modern Xinjiang

In November,1884,the Qing Dynasty established Xinjiang province to promote the social development,making the social changes achieve the peak in modern Xinjiang.The recovery of Xinjiang,the forceful economic growth and the establishment o f Xinjiang Province created a favorable social environment and set up a whole new organizational system for social changes in Xinjiang.The establishment reformed the administration system,reinforced the effective management,abolished the backward Beke system,carefully chose officials,and changed the ethnic separation administration system,which pushed the frontier region administration onto the modern path and strengthened the ties between Xinjiang and inland China that served to resist foreign invasion and consolidate northwestern China frontier defense