SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Real-Time up-conversion luminescence thermometry based on lanthanide doped nanodiamonds in a living cell

This project will develop a novel thermometer based for intracellular temperature sensing application. Success will bring real-time high-resolution probing and imaging of temperature within living cells to the research community; this can promote novel insight about the pathology and, in turn, help establish a powerful tool in terms of its potential to support early diagnoses and therapies in a broad range of disease areas. In this respect the RULE-THERM project aims to contribute a foundational development of a technology with potentially wide applicability. The project brings together a talented young Fellow with a strong nano-science background and an internationally growing group of researchers at Aston University with expertise in diamond-based materials, which offer excellent biocompatibility and thus have a great potential for cellular interface.
Biomechanical analysis of the tibial tray design in TKA: comparison between modular and offset tibial trays

The aim of this work was to develop a computational biomechanical study to compare the performance of tibial trays with different offsets for a total knee arthroplasty. The goal was to investigate whether the offset tibial tray shifts the bone stress distribution, influencing the clinical outcome.Three geometric models were developed for the intact tibia bone: one considering a standard tibia case and the other two reproducing tibias with a medial or a lateral offset of the metaphysis. Appropriate prosthetic components were assembled in the bone for the aforementioned cases. The finite element method was used to obtain the mechanical stress distribution for the models, and the stress shielding effect due to the prosthesis was analysed.The obtained results revealed that the offset cases are subjected to higher stresses than the standard case. These values can be two times superior to the ones verified in a standard case. The stress shielding effect was confirmed along all the analysed paths, except near the stem's end in some areas.The higher stresses registered can originate lower clinical outcomes in the offset cases. These findings can be an important beginning to understand whether better bone stress distribution could be achieved in deformity correction with associated osteotomies instead of offsetting.
Apoyar el mantenimiento de la actividad económica de la empresa en una situación de disminución significativa del volumen de negocios debido a la COVID-19

El proyecto se refiere al apoyo al capital de trabajo de la empresa indicado en el punto II.1 en caso de una disminución significativa del volumen de negocios (ingresos procedentes de las ventas) debido a la interrupción de la economía debido a la COVID-19. La ayuda se utilizará para mantener las actividades de una empresa que se encuentra a raíz de la pandemia de COVID-19 en una situación de escasez repentina o falta de liquidez.
Sources of Math Self-Efficacy: A Case Study of Students in Game Design

Within the past 20 years, the concept of self-efficacy has received considerable attention from educational researchers as they seek to understand student beliefs related to academic activities and academic performance. Recent findings have suggested that sources of self-efficacy differ across race and ethnicity among students. Much more research however, is still needed to further examine this claim. The present study, one of few qualitative studies examining sources of self-efficacy, recruited African American participants from the Game Design @ Mason program and used the Morgan-Jinks Math Self-Efficacy scale to select and interview students. The following research questions were explored: (a) What sources of math self-efficacy do African American students with interests in game design rely upon most? (b) How do sources of self-efficacy differ for students with high math self-efficacy ratings as compared to students with lower math self-efficacy ratings? (c) How do students with high math self-efficacy ratings compare to students with lower math self-efficacy ratings in their preferences for the Game Design @ Mason program? (d) How do students with high math self-efficacy ratings compare to students with lower math self-efficacy ratings in their willingness to share with peers their association to the Game Design @ Mason program? (e) How do female students compare to male students in their descriptions of their sources of math self-efficacy? Results suggest that students primarily relied on mastery experiences and affective states to define their math self-efficacy.
Le principali ricostruzioni del testo dell’edictum de mancipiis vendundis

"L’edictum de mancipiis vendundis", emanato dalla magistratura curule in tema di garanzia per vizi nelle compravendite di schiavi, non ci è pervenuto in via diretta; pertanto, lo studioso della materia della compravendita di schiavi, merx tra le più compravendute nel fiorente commercio romano della Roma preclassica e classica, si trova a doversi misurare con una complicata attività esegetica di ricostruzione del testo. Ancora oggi, risultano indispensabili a tale fine i lavori di epoca ottocentesca di Rudorff e Lenel (i primi a proporre una ricostruzione dell’editto fondata su un metodo sistematico), cui si affianca altresì l’opera, più moderna, di Impallomeni, che restituiscono il testo dell’editto attraverso l’interpretazione di alcuni frammenti dei "commentari ad edictum aedilium curulium" dei giuristi classici; tuttavia i testi spesso non coincidono, risultando anche sensibilmente differenti tra loro nei contenuti. Il presente articolo si propone pertanto l’obiettivo di operare un confronto generale e sistemico tra le principali ricostruzioni del testo dell’"edictum de mancipiis vendundis", attraverso lo strumento grafico della tabella, che riteniamo possa costituire un valido ausilio nell’esegesi delle singole rubriche edittali.
Antifeedant Phytochemicals in Insect Management (so Close yet so Far)

Abstract Recently, the role of plant-based pest control agents has been considered to have significant potential to act as an alternative to synthetic chemicals for integrated pest management as they pose little threat to the environment or to human health. Bioactivity of plant-based compounds is well documented in the literature and is a subject of increasing importance. An antifeedant approach for insect control has been extensively studied, at least at laboratory level, though only a handful of plant-based compounds are currently used in agriculture. The known active plant-based antifeedants belong to groups like chromenes, polyacetylenes, saponins, quassinoids, cucurbitacins, cyclopropanoid acids, phenolics, alkaloids, and various types of terpenes and their derivatives, which have been comprehensively discussed in numerous reviews and books. Therefore, this chapter will not discuss various classes of compounds but will emphasize some of the latest isolated molecules that have significant potential for inducing feeding deterrence in insects. It is also obvious from various studies that each insect species may process these allomones in a thoroughly idiosyncratic way, so that the same compound may have very different fates and consequences in different species of insects, thus pointing to different mechanisms involved in antifeedant action. It can also be visualized that insect feeding deterrents may be perceived either by stimulation of specialized deterrent receptors or by distortion of the normal function of neurons, which perceive phagostimulating compounds. Some plant antifeedants influence the feeding activity through a combination of these two principal modes of action. From a commercial point of view only a few highly active antifeedants have been researched, which makes it impossible to systemize or to predict any molecular motifs in feeding inhibition. Impairment in deterrence resulting from habituation has been suggested that could pose different implications for pest management than does decreased deterrence resulting from increased tolerance to toxic substances. Genetically modified plants, which could produce the active antifeedant substances in amounts high enough to protect the plants from further herbivorous damage, could be a possibility in the future.
Understanding the light-fastness of heritage turkey red textiles through modern dye chemistry and historical dyeing technology to inform sustainable display and access

LightFasTR seeks to increase physical and creative access to Europe’s most profitable globalised textile of the 19th c. Industrial Revolution - Turkey red (TR) printed cotton. TR was famed for colourful bold patterns on a characteristic bright red background. Many 19th c. TR printed cottons survive within the pages of pattern books as well-preserved, vibrant and creative storyboards of forgotten global trade and cultural connections. Museums and archives want to exhibit these collections and increase access, but need to preserve the colours, especially the characteristic red. The 19th c. TR makers’ claim of excellent light-fastness for the red dye is unproven, raising uncertainty about suitable light levels and exposure times for historical TR textile collections. LightFasTR unites the materials and processes of making 19th c. TR with modern dye chemistry and heritage textile conservation science to provide essential guidance for museums and archives. 
LightFasTR draws upon the Fellow’s expertise in dye chemistry and reaction mechanisms, and extensive research knowledge of industrial dyeing, notably madder, the traditional natural dye for TR. The Fellow takes an innovative approach to heritage TR preservation by combining historical research of different 19th c. materials and methods with state-of–the art chemical studies of the colorants in historical and reconstructed textiles. LightFasTR seeks to answer: to what extent do differences in materials, methods, makers and period impact on TR colour light-fastness? How much light exposure is safe for historical TR, particularly the red dyes? Should recommended current light-levels in museums and archives be increased or decreased for TR? The Fellow brings the host organisation a unique skill-set of natural dye chemistry for industrialised dyeing to create a world-class knowledge base in the lost tacit and technical skills needed to needed to understand and preserve Europe’s surviving TR heritage.
Solid-Phase synthesis of imprinted nanoparticles exhibiting glycan epitope recognition in glycoproteins

The present project aims at the preparation of synthetic nanoreceptors exhibiting glycan epitope recognition in glycoproteins, identified to play a critical role in cell biology and diseases. Such nanoreceptors, behaving like antibodies, may cope with the current limitations in the essential step of enrichment of specific glycan subclasses, within studies of the glycoproteome. The preparation of the receptors will proceed through solid-phase synthesis of imprinted polymer nanoparticles, with the potential to deliver entities with size, specificity and solubility characteristics comparable to antibodies. The solid-phase synthesis of NanoMIP will require the immobilization of important monosaccharides (N-acetylglucosamine, N-acetlgalactosamine, mannose), widely found in glycoproteins, onto supporting beads. Several synthetic routes will be studied for the immobilization onto silica or plastic beads . In a reactor, built as a controlled temperature glass column filled with the beads containing immobilized monosaccharide, criteriously selected polymerization or sol-gel mixtures will generate the nanoMIPs, with subsequent selection of the highest affinity particles. The optimum combinations of solid-phase/imprinting protocol will be screened from a myriad of nanoMIPs prepared in different conditions. The performance of the nanoMIPs will be ascertained by setting a competitive enrichment protocol consisting of the incubation with a mixture of N-acetylglucosamine-, N-acetylgalactosamine- and mannose-containing glyproteins and a non-glycoprotein. Sorption isotherm data will be used to derive important binding features such as capacity, binding affinity and selectivity. Patentable robust solid-phases and imprinting protocols, either in standalone or combined manner, are planned outputs of the project, which may, in the near future, be incorporated into existing automated solid-phase synthesis instrumentation, for increased throughput and batch reproducibility.
METHODS AND APPARATUS FOR PROVIDING VIDEO ON DEMAND AND NETWORK PVR FUNCTIONS USING IP STREAMING

Methods and apparatus for supporting on-demand content services, using conventional non-IP based VOD servers are described. The methods and apparatus of the present invention, through the use of a protocol converter and/or a content redirector, can be used to enable a conventional VOD server to supply content to a customer premise equipment (CPE) device which supports IP based content delivery and/or RSTP control of content delivery. The protocol converter of the invention can be implemented as an RTSP-ISA PROXY. The RTSP Proxy converts messages between RTSP (Real-Time Streaming Protocol) to the appropriate ISA protocol signal or another protocol format. The proxy module handles the conversion between these formats and converts a received signal, e.g. message, into the format required by the device which responds by implementing the operation requested by the signal.
The validity of two Omron pedometers during treadmill walking is speed dependent

The purpose of this study was to examine the effects of walking speed on the accuracy of measurement of steps, distance, and energy expenditure of two commercially available Omron pedometers [HJ-720IT-E2 (HJ-720) and HJ-113-E (HJ-113)]. Twenty-four untrained males (age, 22.7 ± 2.8 years; BMI, 24.38 ± 2.19 kg m(-2); body fat (%), 16 ± 2.2; VO(2max), 40.2 ± 6.5 ml kg(-1) min(-1)) and 18 females (age, 22.4 ± 2.9 years; BMI, 21.68 ± 2.43 kg m(-2); body fat (%), 23% ± 1.8; VO(2max), 35.9 ± 2.8 ml kg(-1) min(-1)) walked at five different velocities (54, 67, 80, 94 and 107 m min(-1)) on a treadmill in 5-min stages while wearing three types of pedometers: (a) HJ-720, (b) HJ-113, and (c) Yamax Digi-Walker SW-200 (YAM). Step-count for each pedometer was recorded at the end of each stage and compared with the value of a hand counter. Additionally, Omron pedometers were evaluated on their distance and energy expenditure (against VO(2) measurement with a gas-exchange analyzer) accuracy during each stage. HJ-720 and HJ-113 demonstrated high accuracy (r = 0.80-0.99) at all speeds. YAM underestimated step-count only at 54 m min(-1) (r = 0.46). HJ-720 and HJ-113 overestimated distance at slower speeds and underestimated distance at faster speeds, providing mean distance values that where to within 1.5-4% at 80 m min(-1). HJ-720 and HJ-113 underestimated energy expenditure (gross kilocalories) by 28%, when compared to indirect calorimetry. These results suggest that although the Omron HJ-720 and HJ-113 pedometers are accurate in the measurement of step-count, they demonstrate limited accuracy in the assessment of traveled distance and energy expenditure in a speed-dependent manner.
Exploring QSAR and pharmacophore mapping of structurally diverse selective matrix metalloproteinase-2 inhibitors

Abstract Objectives and Methods Matrix metalloproteinase-2 (MMP-2) is a potential target in metastases. Regression (conventional 2D QSAR) and classification (recursive partitioning (RP), Bayesian modelling) QSAR, pharmacophore mapping and 3D QSAR (comparative molecular field analysis and comparative molecular similarity analysis) were performed on 202 MMP-2 inhibitors. Key findings Quality of the regression models was justified by internal (Q2) and external (R2Pred) cross-validation parameters. Stepwise regression was used to develop linear model (Q2 = 0.822, R2Pred = 0.667). Genetic algorithm developed linear (Q2 = 0.845, R2Pred = 0.638) and spline model (Q2 = 0.882, R2Pred = 0.644). The RP and Bayesian models showed cross-validated area under receiver operating characteristic curve (AUCROC_CV) of 0.805 and 0.979 respectively. QSAR models depicted importance of descriptors like five-membered rings, fractional positively charged surface area, lipophilocity and so on. Higher molecular volume was found to be detrimental. Pharmacophore mapping was performed with two tools – Hypogen and PHASE. Both models indicated that one hydrophobic and three hydrogen bond acceptor features are essential. The Pharmacophore-aligned structures were used for CoMFA (Q2 of 0.586 and R2Pred of 0.689) and CoMSIA (Q2 of 0.673 and R2Pred of 0.758), results of which complied with the other analyses. Conclusions All modelling techniques were compared to each other. The current study may help in designing novel MMP-2 inhibitors.
METHOD OF PRODUCING AN AROMATIZATION CATALYST

According to the subject matter of the present disclosure, a method of producing an aromatization catalyst may comprise producing a plurality of uncalcined ZSM-5 nanoparticles via a dry-gel method, directly mixing the plurality of uncalcined ZSM-5 nanoparticles with large pore alumina and a binder to form a ZSM-5/alumina mixture, and calcining the ZSM-5/alumina mixture to form the aromatization catalyst. The plurality of uncalcined ZSM-5 nanoparticles may have an average diameter of less than 80 nm.
Large deviations and rare transitions in turbulent flows

Many out-of-equilibrium systems undergo transitions from one quasi-stationary state to a radically different one.
Turbulent flows, for instance, exhibit sudden switches between attractors.
It is crucial to understand this phenomenon, both for theoretical reasons and for potential applications to industrial or geophysical flows.
Indeed, abrupt transitions or tipping points are a critical component of climate dynamics, which is a topic of major importance for society as a whole, in addition to being a  scientific subject of uttermost current interest.
Over the past decades, outstanding progress has been achieved in non-equilibrium statistical physics thanks to the theory of large deviations, which provides a natural generalization of the core concepts of equilibrium statistical mechanics: like entropy or free energy, large deviation rate functions encode all the relevant statistical information about an observable, such as its most probable values but also the probability of small and large fluctuations and the transitions between steady-states.
However, large deviation computations have been up to now mostly restricted to relatively simple systems.
This project will further develop cutting-edge analytical and numerical tools to compute large deviations in complex systems such as turbulent flows and the climate.
The new ingredients we will consider are on the one hand, time-dependent attractors, and on the other hand, a complex field structure, since both are key features of geophysical flows.
The goal of the project is at the same time to be able to predict some universal features of rare but high-impact transitions in turbulent attractors or, ultimately, the climate, and to promote novel techniques in rare event simulations which are applicable in an increasingly large spectrum of problems.
Due to the combination of skills from the parties involved, the project will build a fruitful bridge between the statistical mechanics and the climate communities.
Prevalence, Characteristics, and Outcomes of COVID-19–Associated Acute Myocarditis

Acute myocarditis (AM) is thought to be a rare cardiovascular complication of COVID-19, although minimal data are available beyond case reports. We aim to report the prevalence, baseline characteristics, in-hospital management, and outcomes for patients with COVID-19-associated AM on the basis of a retrospective cohort from 23 hospitals in the United States and Europe.A total of 112 patients with suspected AM from 56 963 hospitalized patients with COVID-19 were evaluated between February 1, 2020, and April 30, 2021. Inclusion criteria were hospitalization for COVID-19 and a diagnosis of AM on the basis of endomyocardial biopsy or increased troponin level plus typical signs of AM on cardiac magnetic resonance imaging. We identified 97 patients with possible AM, and among them, 54 patients with definite/probable AM supported by endomyocardial biopsy in 17 (31.5%) patients or magnetic resonance imaging in 50 (92.6%). We analyzed patient characteristics, treatments, and outcomes among all COVID-19-associated AM.AM prevalence among hospitalized patients with COVID-19 was 2.4 per 1000 hospitalizations considering definite/probable and 4.1 per 1000 considering also possible AM. The median age of definite/probable cases was 38 years, and 38.9% were female. On admission, chest pain and dyspnea were the most frequent symptoms (55.5% and 53.7%, respectively). Thirty-one cases (57.4%) occurred in the absence of COVID-19-associated pneumonia. Twenty-one (38.9%) had a fulminant presentation requiring inotropic support or temporary mechanical circulatory support. The composite of in-hospital mortality or temporary mechanical circulatory support occurred in 20.4%. At 120 days, estimated mortality was 6.6%, 15.1% in patients with associated pneumonia versus 0% in patients without pneumonia (P=0.044). During hospitalization, left ventricular ejection fraction, assessed by echocardiography, improved from a median of 40% on admission to 55% at discharge (n=47; P<0.0001) similarly in patients with or without pneumonia. Corticosteroids were frequently administered (55.5%).AM occurrence is estimated between 2.4 and 4.1 out of 1000 patients hospitalized for COVID-19. The majority of AM occurs in the absence of pneumonia and is often complicated by hemodynamic instability. AM is a rare complication in patients hospitalized for COVID-19, with an outcome that differs on the basis of the presence of concomitant pneumonia.
Connected Cities

European citizens travel much further to work and leisure facilities today than in the past. Despite bringing benefits, this huge increase in mobility has led to traffic congestion and pollution, holding back efforts to achieve sustainable development. Public transport can form the basis of more sustainable approaches to mobility. However, the mismatch between older public transport networks and much more modern patterns of city development make trains, trams and buses impractical for many commuters. Decision-makers must integrate transport policy and urban planning into comprehensive strategies for sustainable mobility if they wish to provide genuine alternatives to the car. Connected Cities seeks to develop an overall framework for regional and local sustainable mobility policies. The project aims to use experience gained from existing successes in some partner regions to provide cities and towns with superior public transport networks and high quality, safe urban spaces accessible to the disabled.
POLARITY CONFIGURATIONS FOR PARALLEL OPTICS DATA TRANSMISSION, AND RELATED APPARATUSES, COMPONENTS, SYSTEMS, AND METHODS

Fiber optic connection assemblies for rearranging sets of fiber optic signals arranged in one parallel optical configuration into one or more different parallel optical configurations are disclosed. In one arrangement, two (2) data transmission pairs are connected between one multi-fiber connector from each of two connector sets in a first parallel optical configuration using a common set of fiber positions for each multi-fiber connector. Another two (2) data transmission pairs are connected to the common set of fiber positions of a multi-fiber connector from the first connector set, but are connected to other fiber positions of the multi-fiber connectors of the second connector set, using fiber positions that are not used by the other two (2) data transmission pairs. In this manner, cabling complexity can be reduced with increased signal density within fiber optic cables having a multi-fiber configuration.