SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
117 Metabolomics experiment among workers exposed to 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (TCDD)

<h3>Objectives</h3> Previous occupational studies suggest that 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) exposure may be associated with non-Hodgkin lymphoma (NHL) but findings are inconclusive. Mechanistic studies using global biochemical profiling (metabolomics) could provide supporting evidence for such an association by identifying relevant biological pathways. We applied metabolomics profiling to a cohort of TCDD exposed workers. <h3>Methods</h3> 81 workers who had been exposed to either high (n = 43) or low (n = 38) TCDD levels more than 30 years before serum collection and 63 non-exposed workers (from a comparable factory but without TCDD exposure) were included in the study. Serum ion metabolites were detected using Ultra high Pressure Liquid Chromatography (UPLC) coupled online to a Q-TOF Premier mass spectrometer with a scan range of 70�’1000 m/z. Current plasma levels of TCDD (TCDD<sub>Current</sub>) were determined by high-resolution gas chromatography/isotope dilution high resolution mass spectrometry. TCDD blood levels at the time of last exposure (TCDDmax) were estimated using a one-compartment first order kinetic model. Differentially expressed metabolites were identified using partial least squares (PLS) regression, and Bayesian stochastic search variable selection with spike-and-slab priors of (nonlinear) generalised additive models. <h3>Results</h3> Features that were present in all QC samples and had a coefficient of variation CV &lt;30% were included in the present analyses (n = 421 features). PLS and Bayesian stochastic search variable selection regression analyses revealed no obvious metabolic perturbations associated with TCDD serum levels. <h3>Conclusions</h3> This is the first global metabolomic analysis related to TCDD exposure. No significant features were identified. It is concluded that TCDD exposure at levels present in this study does not lead to significant perturbations of the serum metabolites.
Does the decision-to-delivery interval have an effect on fetal outcome in unplanned caesarean sections?

<h3>Background</h3> In 2010, the RCOG suggested that urgency of caesarean section (CS) represents a continuum of risk rather than discrete categories1 prompting NICE to review its recommendations on decision-to-delivery intervals (DDIs) for unplanned CS.2 As such, category 1 and 2 CS should be performed as quickly as possible, with a category 2 being performed within 75 minutes. Less emphasis was placed on the previous “benchmark” of 30 minutes for all emergency CS.3 <h3>Study objective</h3> To assess whether the DDI for unplanned CS affected fetal outcome. <h3>Methods</h3> A retrospective analysis of all unplanned CS during a 6month period (February-August 2012) in the Horton General Hospital, Banbury. We looked for any correlation between DDIs and outcome – cord blood gases (cord pH &lt;7.05 arterial or &lt;7.1 venous), APGAR scores (&lt;7 at 5minutes) and term admissions to SCBU. <h3>Results and discussion</h3> 4 (57%) grade 1 CS had a DDI of less than and 3 (43%) of more than 30minutes (range 17-45). There was one case of acidosis where the DDI was 25 minutes. 35 (78%) grade 2 CS had a DDI of less and 10 (12%) of more than 75 minutes (range 37-125). One baby from the group DDI&lt;75 minutes was acidotic with low APGARs and another required admission to SCBU compared to none from the group DDI&gt;75 minutes. 71 grade 3 CS were performed with one case of acidosis (DDI 67 minutes). We postulate that this suggests no correlation between DDI and fetal outcome, supporting the concept of a continuum of risk whereby a DDI should be individualised for each case.
Ultra-strong architected Cu meso-lattices

3-dimensional solid Cu octet meso-lattices with characteristic features on the micron-scale were fabricated and mechanically tested under uniaxial compression. These architected cellular materials were fabricated by a three-step process: (1) direct laser writing of the lattice pattern into a polymer template, (2) electroplating of Cu into the template, and (3) removal of the polymer matrix. The microstructure of the electroplated Cu mainly consists of polycrystalline grains with average diameters of 2μm such that cross-sections of lattice beams mostly consist of a single grain. We discovered that the compressive yield strengths of the open-cell Cu meso-lattices can exceed the yield strength of monolithic bulk Cu as measured from a Cu thin film made with identical conditions. Meso-lattices with relative density of 0.8 had a strength of 332 MPa, which surpassed the bulk yield strength by 80%. This is diametrically opposite to predictions from structural mechanics theory, which states that strength scales linearly with relative density for the octet structure. We attribute the ability of solid Cu meso-lattices to attain such high strengths to the “smaller is stronger” size effect present in single crystalline metals with sub-micron dimensions. This work demonstrates the use and proliferation of the size-dependent strengthening unique to nanostructures in an architected structural material.
Fabricating functional components in room temperature

Electroceramics are key materials in all electronics. These ceramic components are used for example in sensing of force, acceleration, and humidity, in energy harvesting, and in frequency tuning of antennas and filters. They are also used for miniaturization and packaging of electronics systems and devices. The main disadvantage of electroceramics is that the fabrication requires relatively high investments and it consumes significant amount of energy due to high sintering temperatures (850-2000 oC). This also makes limitations in contacting and an integration with other materials. However, in the last few years realization of electroceramic components with room temperature fabrication (RTF) has become possible. Our ERC project “Printed Electroceramics with Ultimate Compositions” led to extremely interesting discoveries and opens up a totally new horizons to fabricate functional composites at room temperature. The new finding to use densification process of ceramics at room temperature and post-processing at very low (120 °C) temperature opened a utilization pathway for successful multimaterial system integration.We demonstrated that RTF is feasible for realization e.g. dielectrics based on Li2MoO4 ceramics and its composites while new endeavors in integration will be done in this proposed PoC project. Three main application areas, namely wireless 5G, IoT and automotive are all eagerly looking for new approaches for integration, packaging and sensing. In this Proof-of-Concept we will focus on utilization steps to evaluate RTF composite technology in e.g. accelerometer and antenna components so that the first industrially applicable prototypes and samples can be manufactured and demonstrated.
System and method of vacuum bagging composite parts

A vacuum bag assembly (102) may include a bagging film (104) and a tube bag (200). The bagging film (104) may have a bagging film length and may be positioned over a composite layup (400) and sealed to a tool surface (302) having an inside corner. The tube bag (200) may have opposing tube ends (208) and a tube bag length and may be positioned over the composite layup (400) along a length of the inside corner (304). Each one of the tube ends (208) may be sealed to the tool surface (302) along a first portion of a tube end (208) perimeter edge and may be sealed to the bagging film (104) along a second portion of the tube end (208) perimeter edge such that each one of the tube ends (208) is openable to atmosphere.
An integrated hypothesis for cognitive and positive symptoms in schizophrenia

An integrated hypothesis for cognitive and positive symptoms in schizophrenia:

Schizophrenia is a complex developmental brain disorder with three main clusters of symptoms: (i) positive (psychosis, delusions and hallucinations), (ii) negative (reduced motivation and social withdrawal), and (iii) cognitive (memory and executive function deficits). For the last 50 years, the only effective treatment has consisted of antipsychotics targeting dopamine receptors. Yet, antipsychotics control mostly the positive symptoms and are largely ineffective at treating other deficits. 

It is frequently assumed that distinct pathophysiological mechanisms underlie different symptoms. Psychosis is associated with striatal hyperdopaminergia, probably due to abnormal activity of midbrain dopaminergic neurons. Yet cognitive deficits seem to arise from cortical excitation/inhibition unbalance. I propose to test, in a mice model, the hypothesis that striatal hyperdopaminergia results from dysfunctional cortical inhibition. If verified, this would suggest that normalizing cortical activity in schizophrenia might both restore cognitive function and prevent psychosis.
The role of the serotonergic and GABA system in translational approaches in drug discovery for anxiety disorders

There is ample evidence that genetic factors play an important role in anxiety disorders. In support, human genome-wide association studies have implicated several novel candidate genes. However, illumination of such genetic factors involved in anxiety disorders has not resulted in novel drugs over the past decades. A complicating factor is the heterogeneous classification of anxiety disorders in the Diagnostic and Statistical Manual of Mental Disorders (DSM-IV-TR) and diverging operationalization of anxiety used in preclinical and clinical studies. Currently, there is an increasing focus on the gene × environment (G × E) interaction in anxiety as genes do not operate in isolation and environmental factors have been found to significantly contribute to the development of anxiety disorders in at-risk individuals. Nevertheless, extensive research on G × E mechanisms in anxiety has not resulted in major breakthroughs in drug discovery. Modification of individual genes in rodent models has enabled the specific study of anxiety in preclinical studies. In this context, two extensively studied neurotransmitters involved in anxiety are the gamma-aminobutyric acid (GABA) and 5-HT (5-hydroxytryptamine) system. In this review, we illustrate the complex interplay between genes and environment in anxiety processes by reviewing preclinical and clinical studies on the serotonin transporter (5-HTT), 5-HT1A receptor, 5-HT2 receptor, and GABAA receptor. Even though targets from the serotonin and GABA system have yielded drugs with known anxiolytic efficacy, the relation between the genetic background of these targets and anxiety symptoms and development of anxiety disorders is largely unknown. The aim of this review is to show the vast complexity of genetic and environmental factors in anxiety disorders. In light of the difficulty with which common genetic variants are identified in anxiety disorders, animal models with translational validity may aid in elucidating the neurobiological background of these genes and their possible role in anxiety. We argue that, in addition to human genetic studies, translational models are essential to map anxiety-related genes and to enhance our understanding of anxiety disorders in order to develop potentially novel treatment strategies.
Machine learning based analysis of gender differences in visual inspection decision making

While machine learning is most often concerned with learning from humans, the fact that human behavior systematically differs for (groups of) people with different gender, age, education or cultural background is widely ignored. Obviously, such differences are reflected in the training humans provide to machine learning algorithms that in turn affects the induced models. A coherent set of experiment design and analysis methods is presented which was applied for studying gender differences in visual inspection decision making. Detailed results from a study with 50 female and 50 male subjects are reported. Although immediate performance measures were almost equal, highly significant differences in the structure of induced decision trees have been found (p=0.00005). This demonstrates the value of our contribution for researchers intending to investigate the otherwise hidden structure of cognitive gender differences rather than their merits.
SKIN THERAPY SYSTEMS

A convenient and hygienic skin therapy system comprising an encaser, one or more therapeutic compositions, a sealing means and optional accessories is disclosed. A method of using such a skin therapy system is also provided. The skin therapy system and the use thereof provides an effective, efficient and safe therapeutic approach.
Programa Adaptación de las PYME

Habida cuenta de la nueva realidad de la COVID-19 y del riesgo de propagación del SARS-CoV 2, será necesario reestructurar las instalaciones y actividades dentales para garantizar la máxima seguridad no solo para los pacientes sino también para los profesionales de la salud.
ELECTRIC LUMINAIRE

Um eine elektrische Leuchte, zumindest aufweisend ein Leuchtengehäuse mit Boden und Seitenwänden, mit mindestens einem Reflektor, zudem aufweisend eine Leuchteneinheit mit Kühler und mindestens einer lichtemittierenden Diode (LED), die von dem Reflektor umgeben oder zwischen den Reflektoren angeordnet ist, wobei der Lichtaustritt der LED oder der LEDs etwa horizontal in Richtung des Reflektors oder der Reflektoren erfolgt, zu schaffen, bei der auf schnelle und besonders einfache und dabei auch durch einen Laien reproduzierbare Art und Weise der Lichtaustrittswinkel insbesondere zur Ausleuchtung von Objekten wie Regalen einstellbar und somit an das jeweilige Regal anpassbar ist, die dabei kostengünstig und einfach zu fertigen ist und eine hohe Lebensdauer aufweist, wird vorgeschlagen, dass die Leuchteneinheit mit Kühler (5) und LED (6) höhenverstellbar gegenüber dem Boden (2) des Gehäuses und gegenüber dem Reflektor (4) oder den Reflektoren (4) angeordnet ist, wobei je nach Höhe des Lichtaustritts aus der LED (6) ein anderer Bereich des Reflektors (4) oder der Reflektoren (4) angestrahlt und somit der Lichtaustrittswinkel vergrößerbar oder vergrößert beziehungsweise verkleinerbar oder verkleinert ist.
Transformation of tea catechins and flavonoid glycosides by treatment with Japanese post-fermented tea acetone powder

Japanese post-fermented teas are produced by a combination of aerobic and anaerobic microbial fermentation of the leaves of tea plant. Recently, it was revealed that tea products contain characteristic polyphenols identical to the tea catechin metabolites produced by mammalian intestinal bacteria, such as (2S)-1-(3′,4′,5′-trihydroxyphenyl)-3-(2″,4″,6″-trihydroxyphenyl)-propan-2-ol (EGC-M1). In the present study, degradation of epigallocatechin-3-O-gallate (EGCg) and epigallocatechin (EGC) with acetone powder prepared from Japanese post-fermented tea was examined. Under aerobic conditions, EGCg was hydrolysed to EGC and gallic acid, which were further converted to gallocatechin (GC) and pyrogallol, respectively. Under anaerobic conditions, EGCg was hydrolysed to EGC, which was further metabolised to GC, EGC-M1 and (4R)-5-(3,4,5-trihydroxyphenyl)-4-hydroxypentanoic acid (EGC-M2). Gallic acid was degraded to pyrogallol and then further decomposed. Anaerobic treatment of EGC with the acetone powder yielded EGC-M1, EGC-M2, (4R)-5-(3,4,5-trihydroxyphenyl)-γ-valerolactone, and (4R)-5-(3,4 -dihydroxyphenyl)-γ-valerolactone. Furthermore, similar anaerobic treatment of rutin and hesperidin yielded 3,4-dihydroxyphenylacetic acid and 3-(3,4-dihydroxyphenyl)propanoic acid, respectively.
Talons cusp: a review and case report of mesiolabially rotated maxillary lateral incisors

A case of bilateral talon cusp in maxillary lateral incisors, a relatively rare condition, is presented. The aetiology and clinical problems are discussed. The aim of this case report is to present an esthetically managed maxillary left lateral incisor associated with a talon cusp. This case report describes restorative considerations for a successful, functional, and esthetic rehabilitation of the tooth. Talon cusp is an anomaly occurring in permanent incisors of either arch. Its occurrence raises problems in esthetics, caries control, and occlusal accommodation for the patient and problems in diagnosis and clinical management for the dentist. Key Words: Talon's cusp, esthetic management, occlusal accommodation.
Memory and betweenness preference in temporal networks induced from time series

We construct temporal networks from time series via unfolding the temporal information into an additional topological dimension of the networks. Thus, we are able to introduce memory entropy analysis to unravel the memory effect within the considered signal. We find distinct patterns in the entropy growth rate of the aggregate network at different memory scales for time series with different dynamics ranging from white noise, 1/f noise, autoregressive process, periodic to chaotic dynamics. Interestingly, for a chaotic time series, an exponential scaling emerges in the memory entropy analysis. We demonstrate that the memory exponent can successfully characterize bifurcation phenomenon, and differentiate the human cardiac system in healthy and pathological states. Moreover, we show that the betweenness preference analysis of these temporal networks can further characterize dynamical systems and separate distinct electrocardiogram recordings. Our work explores the memory effect and betweenness preference in temporal networks constructed from time series data, providing a new perspective to understand the underlying dynamical systems.
Assessing Microbial Safety of Drinking Water: Improving Approaches and Methods

Inadequate drinking water quality and poor sanitation have remained the world's major causes of preventable morbidity and mortality. In 1996 the OECD called for concerted action to improve the assessment and management of the world's sources of drinking water.

This guidance document seeks to respond to this call. It is the product of a shared initiative between the OECD and the World Health Organization. It is a state-of-the-art review that will contribute to the revisions of the WHO's Guidelines for Drinking Water Quality.

Assessing Microbial Safety Of Drinking-water has elements of both revolution and evolution. It is revolutionary in that it supports a rapidly emerging approach for a broader, system-wide management perspective.

This is based on a risk management framework that has evolved from the traditional indicator concept to include multiple parameters and where consideration is also given to tolerable risk, water quality targets and public health status.

This title belongs to WHO Drinking-water Quality Series. .

ISBN: 9781780405872 (eBook)

ISBN: 9781843390367 (Print)
Maternal fever during early pregnancy and the risk of oral clefts

An increased risk of birth defects after hyperthermic exposures has been confirmed in animal studies, but population studies have yielded inconsistent results. Oral clefts are a common birth defect and have been associated with these exposures in some of these studies. In this study, data from the National Birth Defects Prevention Study was used to evaluate the association of maternal report of febrile illness in early pregnancy and the risk of oral clefts. All oral cleft cases born between 1997 and 2004 were compared with nonmalformed controls born in the same geographical region during the same time period. Mothers reporting febrile illness during pregnancy were stratified by fever grade and antipyretic use. Logistic regression models were used to generate crude and adjusted odds ratios for exposure to fever and association with each oral cleft phenotype. The dataset included 5821 controls, 1567 cases of cleft lip with or without cleft palate (CL+/-P) and 835 cases of cleft palate only. A modestly increased risk was observed for isolated CL+/-P (odds ratio, 1.28; 95% confidence interval, 1.01-1.63). Stratification by fever grade (body temperature <101.5 degrees or > or =101.5 degrees F) did not yield significant differences in risk. Risk estimates were higher among women who reported a fever, but did not take antipyretics to control their fever, particularly for nonisolated compared with isolated oral clefts. This finding suggests that adequate control of fever may diminish the deleterious effects of fever in cases of oral cleft.
Piecing the Puzzle Together: Genetic Requirements for miRNA Biogenesis in Arabidopsis thaliana

MicroRNAs (miRNAs) are an important class of endogenous small silencing RNAs in both plants and animals. They regulate the expression of a wide range of target genes that are involved in many important biological processes. Biogenesis of plant miRNAs requires a distinct set of proteins, including members that belong to several highly conserved RNA silencing protein families. The framework for miRNA biogenesis in plants was revealed through genetic and biochemical analyses using mutants that are defective in miRNA accumulation. These general miRNA-deficient mutants constitute a set of invaluable genetic resources for the plant miRNA research community. They could be utilized to experimentally validate the candidate miRNAs that are either predicted by a computational program or recovered from a small RNA deep sequencing effort which is becoming a more affordable and widely used approach for small RNA discovery. Starting with a brief introduction on multiple small RNA pathways in plants, this chapter provides basic experimental procedures for the examination of miRNA accumulation from wild type plants and various mutant lines in Arabidopsis.
Solar energy, 24 hours, year-round. on or off-grid.

The hydrogen-based Solenco Powerbox allows solar or wind power to be privately stored for hours or months, allowing 24 hour, year-round renewable electric power and heat, independent of the power grid. Powerbox allows every home and business to cheaply store their own generated energy, with over 90% conversion efficiency, electric and heat storage. 
The Solenco Powerbox is a heavily-patented combination of an electrolyzer and a fuel cell in one unit. It transforms electricity into hydrogen, stores it indefinitely, then converts hydrogen back into electricity and/or heat, at minimal loss. Heat comes out as hot water at a rated temperature of 80°C. 
Unlike battery storage, the Powerbox stores heat as well as electricity. There is no degradation of conversion capacity over time – its working lifetime is over 30 years. Unlike natural gas storage, there is no need to draw on local underground storage capacity. Unlike hydroelectric power storage, there is no need for local mountains or lakes to be available. Unlike chemical storage, there is no hazardous storage, transport or disposal concern. 
Our method has zero carbon footprint and works anywhere, allowing homes and businesses to be heated and powered with intermittent solar and/or wind storage and even to feed excess power into local city grids as needed.
Solenco will be powerful to commercialize, since it has comparable cost to existing inferior solutions, and has the fastest return on investment (<3 years) of any storage solution on the market. Powerbox is targeted at the EU-28 residential renewable energy market of €33.6B (2016), which continues to grow rapidly. Our founder has created hundreds of energy jobs in Europe.
Solenco won the Hansa Green Tour Startup Challenge in 2018 and will earn 530,000 Euros in 2019.