SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Applying grading methods of synthesizing multiple guidelines to optimizing alcohol-steam processing technology from Ploygonatum odordatum

In order to improve the quality of processed products and application in the field of medicine or healthy food,we optimized the alcohol-steam processing technology of Ploygonatum odordatum.On the basis of the content and antioxidant activity of the saponins,polysaccharose,total flavonoids,ethanol extracts and water extracts,the best extracted technology was generated using orthogonal test coupled with grading methods of synthesizing multiple guidelines.The results showed that the optimal technology was 2 h alcohol-moistening,5 times the amount of solvent,60 ℃ for 1 h,and the material-liquid ratio was the most significant influence factor.This method had effectively raised the utility value of Ploygonatum odordatum.[Ch,1 fig.6 tab.31 ref.]
Characterization of rtel1 mutations in hoyeraal-hreidarsson syndrome

Hoyeraal-Hreidarsson syndrome (HHS) is a multisystem disorder with patients presenting inter-uterine growth retardation, immunodeficiency, and/or aplastic anaemia. Recently, mutations in RTEL1 have been shown to be causal for this disease. RTEL1 prevents genomic instability and maintains integrity of the telomeres by disassembling different secondary structures that arise during DNA replication, repair, and recombination.Although recent discoveries from the host lab and others have shed light on the function of RTEL1 in maintaining genome stability, many outstanding questions remain to be addressed. Currently very little is known about RTEL1 regulation or how it is dynamically recruited to replication forks and telomeres to execute its functions. Moreover, it is not known whether RTEL1 expression or recruitment is regulated by post-translational modifications. 
 
Of the 18 identified mutations, only two have been characterized. As these undefined mutations are causal for HHS and must therefore affect the RTEL1 function, their detailed characterization is likely to shed light on new aspects of its function and/or regulation. The main objective of this project is to characterize the undefined HHS mutations in RTEL1 and determine how they impair the physiological protein function, in vitro and in vivo.

To this end, we will take advantage of a complementation system that permits the stable expression of RTEL1 variants in RTEL1 deficient cells, allowing us to study RTEL1 mutant contribution to RTEL1 phenotypes. We will also perform comparative proteomic analysis of the mutants to determine if they abolish specific/novel protein-protein interactions. HHS mutations that present with a defined phenotype or affect a novel interaction will be studied in vivo in a mouse model. 

In summary, we anticipate that the combination of approaches proposed here holds the potential to significantly contribute towards the understanding of how different mutations affect RTEL1 function.
Functional electrical stimulation for at home rehabilitation

The Context
Stroke has huge human and economic cost. 1 million people suffer strokes in Europe every year, with an average life expectancy after stroke of 8 years.  Roughly 20% of stroke survivors suffer from drop foot, with 45 billion euros spent on rehabilitating stroke patients in Europe every year.
The opportunity:
 FES offers the tantalising prospect of retraining voluntary motor functions such as walking. However:
-	FES rehabilitation must be carried out in a hospital with the support of trained healthcare professionals;
-	Transporting patients and supervising treatment is expensive;
-	Patient’s treatment plan is sub-optimal;
-	Per patient rehabilitation costs reach 32,000 euros 
Our solution: 
Fesia WalkHome is a FES rehabilitation device for drop foot patients which can be administered by the patient in their own home. This not only reduces costs by 43% but also means patients can have an optimal treatment plan, improving their speed of recovery. 
The use of Fesia Walk at home will give autonomy, independence and improve the quality of life for chronic patients. It will also mean a substantial reduction of waiting lists, health costs, number of physician office visits, and carer support.
The Project:
WalkHome represents a disruptive change of paradigm for the FES rehabilitation standard of care. The aim of the phase 1 project is to improve our understanding of the EU market for FES rehabilitation, identifying regional market variations in terms of key decision makers, appropriate business models, pricing structure and identifying which are the most attractive markets for us to use as a beachhead. We will also analyse what key improvements need to be made to the existing technology to create the new FES home care rehabilitation market.
The Market:
Currently, there is no FES rehabilitation technology that is offered outside of a clinical setting. We estimate that this new home FES rehabilitation market could be worth up to 40 billion euros in Europe alone.
Interfacing spin waves with superconducting quantum circuits for single magnon creation and detection

The proposed project will experimentally interface ferromagnets with superconducting quantum circuits to study dynamics within the magnet. To this end, magnonic elements made up by thin, structured magnetic films will be strongly coupled to the qubit. Superconducting qubits are ideal detectors due to their quantum limited back-action on the measured object and energy resolution.

Spectroscopy and coherence measurements on the hybrid system will be made in order to address fundamental aspects such as spin wave generation, detection, coherence, or wave propagation down to mK temperatures and at ultra-low power (atto-watts). Amplitude and phase noise of spin wave resonators will be determined. At the final stage of the project, the quantum limited resolution of qubits will facilitate single magnon creation and detection. Quantum states are swapped between qubit and magnon, and superpositioned and entangled states will be explored. Monitoring the qubit response to its magnetic environment the low and high-frequency flux noise spectrum of spin waves will be inferred.

The research methodology employs junctions, resonators, and qubits as research objects and detectors. The samples will be characterized at cryogenic temperatures by transport, magnetometry, resonator and qubit setups. Magnetic materials will be deposited and structured beneath or ontop the superconducting quantum circuits.

Exploring spin wave dynamics in thin films by coupling to a superconducting qubit complements conventional measurement techniques based on photon, electron or neutron scattering methods, which require highly populated excitations. The project connects to and extends research objects of ground-breaking nature to open up new horizons for quantum, magnon and spin electronics. Magnetic material physics is enhanced by new research concepts such as quantum resolved spectroscopy and coherence measurements on intrinsic dynamic states.
METHOD AND APPARATUS FOR PRODUCING AND STORING A FLOWABLE SLUSH, PARTICULARLY FOR ICE PIGGING

An apparatus for generating and storing in a tank (22) a flowable slush (2) of frozen particles usable inter alia in ice pigging comprises a control system (100) which is arranged to monitor an operating parameter OP of an agitator (23) in the storage tank. The control system initiates a slush comminution and separation or dewatering cycle when a control parameter CP based on the operating parameter OP reaches a threshold value CPt. The control parameter may represent a cumulative energy input to the storage tank (22). Comminution may be performed prior to separation, with the treatment cycle being terminated when a sensed rheometric parameter RP of the slush circulating in the treatment flowpath reaches a target value RPt.
PRÉVENTION DE LA COVID-19

ADOPTION DE MESURES DE PROTECTION ET DE PRÉVENTION EN MATIÈRE DE SÉCURITÉ SUR LE LIEU DE TRAVAIL POUR LUTTER CONTRE LA PANDÉMIE DE COVID-19
APPARATUS AND METHOD FOR CONTROLLING OR LIMITING ROTOR ORBIT IN MOVING CAVITY MOTORS AND PUMPS, SUCH AS MUD MOTORS

A moving cavity motor or pump, such as a mud motor, comprising: a rotor, a stator, and one or more apparatus for constraining (i.e., controlling or limiting) the movement of the rotor relative to the stator.
Design and analysis of a spectro-angular surface plasmon resonance biosensor operating in the visible spectrum

Surface plasmon resonance (SPR) sensing is one of the most widely used methods to implement biosensing due to its sensitivity and capacity for label-free detection. Whilst most commercial SPR sensors operate in the angular regime, it has recently been shown that an increase in sensitivity and a greater robustness against noise can be achieved by measuring the reflectivity when varying both the angle and wavelength simultaneously, in a so-called spectro-angular SPR biosensor. A single value decomposition method is used to project the two-dimensional spectro-angular reflection signal onto a basis set and allow the image obtained from an unknown refractive index sample to be compared very accurately with a pre-calculated reference set. Herein we demonstrate that a previously reported system operated in the near infra-red has a lower detection limit when operating in the visible spectrum due to the improved spatial resolution and numerical precision of the image sensor. The SPR biosensor presented here has an experimental detection limit of 9.8 × 10(-7) refractive index unit. To validate the system as a biosensor, we also performed the detection of synthetic RNA from pathogenic Legionella pneumophila with the developed biosensing platform.
Consume Less in Mediterranean Touristic Communities

Most of the coastal cities in the MED area are interested by high touristic flows. This creates relevant economic and employment opportunities, but generates at the same time negative externalities that threaten the preservation of those ecosystem services that ensure tourism attractiveness. The development of a sustainable tourism in coastal cities is thus a strategic issue in the MED area.
The CONSUME-LESS project faces this issue by demonstrating the effectiveness of a sustainable tourism model based on the qualification of the coastal cities as “consume-less” locations and on the enhancement of this peculiarity through an innovative communication and territorial marketing campaign, both implemented by directly involving all interested actors (local authorities, tourism operators and service providers, tourists).
This will bring multiple benefits, that will be carefully monitored and accounted for through the use of a suitable set of indicators, based on the European Tourism Indicators System. Expected benefits are the reduction in water and energy consumption and waste generation, the enhancement of local products and natural resources, the increase in tourism flows and in tourists awareness on the importance of adopting environmentally sound lifestyles.
The transnational approach is fundamental in the project, as it allows to test the effectiveness of the consume-less model in different contexts, thus enabling the assessment of its wide replicability in the MED area.
Mediterranean Inter Cluster

Cluster policy is a priority in the Mediterranean regions taking part in the ICMed partnership. ICMed will address the issues and challenges facing cluster policy by focusing on 5 specific themes and putting SME competitiveness and innovation at the heart of the project. The ICMed work programme will cover a 3 year period. First, a series of activities will be launched in order to identify the areas of interest for transnational cooperation, to then identify intercluster networks which will be involved in the selection and launch of the pilot cooperation projects. The project aims to achieve three main strategic goals: 1. Develop intercluster partnerships ; 2. Design and implement cooperation projects between business clusters and laboratories ; 3. Foster the integration of innovation support actors (incubators, technology transfer structures…)
IMPROVED PINNED ROLLERS AND PROCESSES FOR MANUFACTURING FIBRILLATED FILMS

Roller (10) has a cylindrical surface (12) from which project pins (16) inclined at an angle (A) between 20 and 80 to the tangent to the roller. The pins have a projection length of 0.5 to 2.0 mm and a diameter of 0.2 to 0.8 mm. They are arranged in double rows (14) with 25 to 34 pins to the inch arranged in a spaced staggered relationship in two adjacent lines. Each row is either inclined to a line parallel to the axis of the roller or of sinusoidal form. A film to be fibrillated is advanced over the surface of the rotating roller for an arc length of contact of 30 to 37 with the ratio of the surface speed of the roller to that of the advancing film being between 1.8 to 1 and 2.2 to 1.
METHOD AND APPARATUS FOR AUTOMATED VERTICAL HORTICULTURE AND AGRICULTURE

A method and apparatus for continuous automated growing of plants utilizes a vertical array of plant supporting arms extending radially from a central axis. Each arm has a plurality of pot receptacles which receive the plant seedling and liquid nutrients and water. The potting arms are rotated beneath grow lamps and pollinating arms. The frequency of feeding is increased as the plants grow. CO2 enriched air may also be provided. Once the plants are ready to harvest, they are manually exchanged for new seedlings and packaged.
The Critical Factors Responsible for Fairness in Managing Employee Dismissal in Some Textile Manufacturing Industries in Nigeria

This study investigated the critical factors responsible for fairness in managing dismissal of employee in Textile industries. Dismissal without laid down procedure has cost textile industries in Nigeria huge sum of money in financing litigations. It is a huge source of economic drain to the industry. Litigation has negative impact on the financial status and progress of the organization. Dismissal without recourse to the rules and regulations and the contract arrangement stated by the employer is deemed unfair. There must be grounds for dismissal and dismissal must be fair otherwise the employee will seek retribution in court. The data utilized in this research was collected through cross-sectional survey. The data was utilized in answering research questions and testing hypothesis. The analysis of data collected from questionnaire instrument was done using percentages (%) and Z-test statistics. Analysis of data according to research questions showed that the grounds for dismissal were misconduct, insubordination, lack of qualification for the job, unsatisfactory performance and change requirement of the job. Misconduct was found as the foremost ground for dismissal in Enpee Plc and Afprint Plc. All the variables hypothetically tested as a factor responsible for fairness in managing employee dismissal has significant effect on textile industries in Nigeria. The textile industries should adhere to all the principles outlined in the study that is contingent to fairness in dismissal in order to avoid wrongful dismissal and incessant retribution in court by employees.
Superconductive mir photon counter

Quantum measurements based on single photon detectors (SPDs) can be efficiently carried out in the visible and near-infrared spectra due to the presence of two well-established technologies named silicon avalanche photodiodes and superconductive nanowire SPDs (SNSPDs). However, the mid-infrared (MIR) spectral range suffers from the absence of a fast SPD with high system detection efficiency (SDE) due to the lack of a competitive semiconductor technology or the poor absorption of the SNSPD systems showed so far. Vibrational modes of molecules and absorption bands of gases resides in this wavelength range, making a detector sensible to MIR single photons extremely sought for sensing and vibrational spectroscopy. Additionally, this wavelength range can be used efficiently for free-space QKD, being robust against adverse weather conditions. These are only but a few of the numerous applications that would benefit or be enabled by a performant SPD. 
The research goal of this proposal is to realize a Superconductive MiR phOton Counter (ShaMROCk) that outclasses all the existing technologies in terms of SDE, providing a solid platform for additional functionalities. SNSPDs realized so far suffered from the top-coupling approach that limits the interaction length between photons and the detector active area since the large diffraction limited mode of MIR light and the lack of MIR optical cavities. On the other side, in ShaMROCk I intend to integrate SNSPDs on top of MIR waveguides, realized using silicon carbide. All the light propagating inside the waveguide, evanescently coupled to the active are of the detector, can be absorbed in this way. The SDE is therefore limited by the efficiency with which light is coupled from a fiber to a waveguide. Preliminary results shows that ShaMROCk could provide a SDE twenty times higher than top-coupling SNSPD and two order of magnitude higher than other pursued technologies. This project will pave the way for MIR quantum measurements.
Animals make identities. the social bioarchaeology of late mesolithic and early neolithic cemeteries in north-east europe

AMI aims to provide a novel interpretation of social links between humans and animals in hunter-gatherer cemeteries in North-East Europe, c. 9000–7500 years ago. AMI brings together cutting-edge developments in bioarchaeological science and the latest understanding of how people’s identities form in order to study the relationships between humans and animals. Grave materials and human remains will be studied from the viewpoint of process rather than as isolated objects, and will be interpreted through their histories.

The main objectives are
1) Synthesize the animal related bioarchaeological materials in mortuary contexts in North-East Europe,
2) Conduct a systematic multimethodological analysis of the animal-derived artefacts and to study them as actors in human social identity construction,
3) Reconstruct the individual life histories of humans, animals, and animal-derived artefacts in the cemeteries, and
4) Produce models for the reconstruction of social identities based on the data from the bioanalyses, literature, and GIS. 

Various contextual, qualitative and quantitative biodata from animals and humans will be analysed and compared. Correlations and differences will be explored. Intra-site spatial analyses and data already published on cemeteries will contribute significantly to the research. Ethnographic information about recent hunter-gatherers from circumpolar regions gathered from literature will support the interpretation of the results from these analyses.

The research material derives from almost 300 burials from eight sites in North-East Europe and includes, for example, unique materials from Russia that have not previously been available for modern multidisciplinary research. The project will make a significant contribution to our understanding of how humans living in the forests of North-East Europe adapted the animals they shared their environment with into their social and ideological realities and practices.
Writer identification for offline Tamil handwriting based on gray-level co-occurrence matrices

Writer identification is a popular research field in many languages. Since alphabets of different language have different pattern, the methods are dependent on the language. Handwriting of a person has some features which are unique to every person and can be used for identification. Most of the research activities for writer identification are based on English documents and the research activities for Tamil handwriting are thin and databases are not available. In this paper, a method is proposed to identify a writer from the scanned images of Tamil handwritten text. Our approach is based on texture analysis where each writer's handwriting is treated as a different texture. The method is text independent and based on the features extracted from gray level co-occurrence matrix of the scanned image. Handwriting samples from 70 writers were used and the documents were scanned with 150 dpi.
Effect of migration and environmental heterogeneity on the maintenance of quantitative genetic variation: a simulation study

The paradox of high genetic variation observed in traits under stabilizing selection is a long-standing problem in evolutionary theory, as mutation rates appear too low to explain observed levels of standing genetic variation under classic models of mutation-selection balance. Spatially or temporally heterogeneous environments can maintain more standing genetic variation within populations than homogeneous environments, but it is unclear whether such conditions can resolve the above discrepancy between theory and observation. Here, we use individual-based simulations to explore the effect of various types of environmental heterogeneity on the maintenance of genetic variation (VA ) for a quantitative trait under stabilizing selection. We find that VA is maximized at intermediate migration rates in spatially heterogeneous environments and that the observed patterns are robust to changes in population size. Spatial environmental heterogeneity increased variation by as much as 10-fold over mutation-selection balance alone, whereas pure temporal environmental heterogeneity increased variance by only 45% at max. Our results show that some combinations of spatial heterogeneity and migration can maintain considerably more variation than mutation-selection balance, potentially reconciling the discrepancy between theoretical predictions and empirical observations. However, given the narrow regions of parameter space required for this effect, this is unlikely to provide a general explanation for the maintenance of variation. Nonetheless, our results suggest that habitat fragmentation may affect the maintenance of VA and thereby reduce the adaptive capacity of populations.
Three dimensional simulation of microstructure evolution for ceramic tool materials

Abstract The observation and scientific quantitative characterization of three dimensional microstructure evolution during sintering process of ceramic tool materials is important to investigate the influence of nano-particles on mechanical properties. The relationship between microstructure and mechanical properties of ceramic tool materials can be established to direct the development of nano-composite ceramic tool materials by the research of the grain growth, grain boundary migration, distribution of nano-particles and microstructure densification at the different sintering temperature and pressure. In this paper, a 3D Monte Carlo model of three-phase nano-composite ceramic tool material is built and applied to simulate the microstructure evolution during sintering process. In this model, the grain boundary energy of each phase and interfacial energy between two phases are taken into consideration as the driving forces for grain growth. The sintering temperature and pressure are successfully coupled into the Monte Carlo simulation model. The microstructure evolution of defect free three-phase nano-composite ceramic tool materials is successfully simulated at different sintering temperature and pressure. The simulation results show that the higher the sintering temperature is, the faster the grain growth. However, the sintering pressure has little effect on the grain growth.