SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Phase-Separated block copolymer nanoparticles for spatial organization of enzymes: a new strategy to control enzyme cascade reactions

Nature has the unique ability to program macroscopic functions via the morphology of nano-scopic systems. One way the cell can control a certain metabolic pathway is by spatial separation of functional macromolecules. Transferring this high level of control to artificial materials would allow not only to study the influence of spatial effects on biochemical pathways, but also to develop new technologies for non-cellular applications. These include the environment-friendly and high-yielding preparation of valuable chemicals or synthetic intermediates. To address this task, the proposed project will exploit the power of controlled block copolymers phase-separation in the confinement of nanoparticles. Nanoparticles can provide structural support and spatial proximity that could ultimately increase product formation. In this context, nanostructured particles are ideal candidates providing unique domains for enzyme compartmentalization by external post-assembly functionalization. In this research project we propose to use poly(styrene)-block-poly(butadiene) nanoparticles as a matrix for post-assembly and domain-selective anchoring of enzymes. For this, two new functionalized polymeric surfactants will be obtained: poly(styrene)-block-poly(ethylene glycol)-""X"" and poly(butadiene)-block-poly(ethylene glycol)-""Y"". Where ""X"" and ""Y"" represent orthogonal reactive groups, which should allow selective attachment of any two enzymes. We proposed the synthesis of striped ellipsoidal nanoparticles where each domain will contain one type of enzyme of a cascade system. We aim for this tandem configuration of one enzyme next to the other to increase the rate of the overall enzymatic reaction. The success of this project could ultimately change the paradigm of the conventional chemistry industry to an environment-friendly approach.
Frontotemporal Dementia: Identification and Management

Abstract Dementia is a disease primarily affecting older adults in their ability to carry out daily activities. Frontotemporal dementia (FTD), a leading cause of early-onset dementia, can present in the fourth and fifth decade by progressive changes in personality, affect, and behavior. The atypical presentation of FTD may resemble a midlife crisis, depression, schizophrenia, or a traumatic brain injury among its causes. The etiology of FTD is unknown, although genetic links have been suggested, thus treatment focuses on behavioral and symptom management. Early diagnosis of FTD is needed to better support the emotional and financial burdens of family and caregivers.
Next evolution in materials and models for ocean energy

NEMMO will design, model and test downscaled prototypes of larger, lighter and more durable composite blades for >2MW floating tidal turbines to reduce LCoE of tidal energy to €0.15/kWh, meeting 2025 SET-Plan targets and making it competitive to competing fossil fuel sources. Novel blade designs with enhanced hydrodynamic performance due to the implementation of the different solutions, active flow control, materials and surfaces will be tested. Also, new nano-enhanced composites with properties that increase fatigue-, impact-, cavitation- and bio-fouling resistance of novel blade designs to prevent failures will be made. The project will then model, design and test the lifespan and resistance of the new composites for tidal turbine blades. This will involve: • accurate modelling of harsh hydrodynamic and environmental stresses for the development of testing and validation procedures • a new test rig for the evaluation of fatigue and cavitation on test probes and downscaled prototypes • a testing procedure including bio-fouling and marine environments evaluation in four different real scenarios • development of numerical models for the prediction of lifespan and mechanical properties as function of the materials properties, hydrodynamic loads, time and water composition • Novel tidal generator blades designs integrating active control flow, advanced surfaces and new nano-enhanced composites. The collective result of these innovations is 70% reduction in LCoE for tidal energy due to; (i) 50% CapEx reduction (lower material consumption and 25% lower cost of new composites), (ii) 2% lower FCR (increased understanding of failure and fatigue mechanisms and more durable composites with 66% higher lifespan), (iii) 40% reduction in O&M (reduced cavitation wear, bio-fouling and aging) and, (iv) 20% increase in AEP (enhanced hydrodynamic performance and higher inlet flow speeds for tidal turbine).
Single cell biophysics of bacterial cell shape

In bacteria, the rigid external cell wall (CW) and the intracellular actin-like (MreB) cytoskeleton are major determinants of cell shape. Synthesis and chemical composition of the CW, a three dimensional polymer network that is one of the most prominent targets for antibiotics, are well understood. However, despite decades of study, little is known about the complex CW ultrastructure and the molecular mechanisms that control cell shape in time and space. MreB homologues assemble into dynamic membrane-associated structures thought to control shape by serving as organizers for the movement and assembly of macromolecular machineries responsible for CW biogenesis. However, the mechanistic details used by the MreB cytoskeleton to fulfill this role remain to be elucidated. 
We will combine powerful genetic tools available in the model Gram-positive bacterium Bacillus subtilis with modern high-resolution fluorescence microscopy techniques and atomic force microscopy (AFM) to study the role of the MreB cytoskeleton and CW synthesis proteins in cell shape determination and maintenance. Additionally, the role of mechanical forces in the control of CW organization will be evaluated.
Optimization of Capacity of Ports within a Regional Port System

In some developing countries, the port industry is going through rapid expansion, and regional port systems (RPSs) are gaining importance in their regional and national economies. In an idealized RPS, outbound freight generated within the region can be routed through any of the ports within the RPS. Commodity-handling capacities of ports within the RPS have a significant impact on the efficiency of commodity flow within the system. A bilevel optimization model that captures the interaction between the decisions of port capacity and commodity flow was developed in the context of a developing country with an export-oriented economy. In this model, a social planner optimizes the whole system by determining the capacity of each port to minimize certain regional logistics costs, taking into account that shippers in demand-generating hinterland regions determine the amount of shipments to each port on the basis of many factors, including the capacities of ports. A heuristic model was developed to solve the lower-level shipper-choice problem. This heuristic is not only based on discrete choice but also factored in port capacity constraints. The genetic algorithm was applied to solve the upper-level capacity-determination problem. The model was successfully applied to a port system containing 15 ports and 13 hinterland regions in Jiangsu province of China.
An education programme to increase general practitioners’ awareness of their patients’ employment: design of a cluster randomised controlled trial

Work and being able to work are important prerequisites for health and well being. Health problems can have a negative influence on the ability to work and not being able to work can be detrimental for patients' psychosocial well being. Although GPs are aware of this importance they do not always structurally pay attention to patients' work during their daily practice.To investigate whether GPs can be trained to increase their awareness of work and improve their skills when dealing with work related problems we designed a cluster randomised controlled trial. The intervention in this trial is a tailored training based on the findings of qualitative research with focus groups of GPs. Gender aspects received specific attention in these focus groups. Primary outcome measures are self efficacy of patients concerning return to work, and GPs' use of ICPC code Z05 (work problems) and registration of patients' occupation. Secondary outcome measures are work awareness of GPs as perceived by patients, quality of life, health, use of care and illness related costs. A process evaluation will be part of our study.We investigate a training to increase work awareness among GPs, improve their skills in managing work related problems and structurally register work related data in the EMR. We think this study will make a contribution to better health care for workers by motivating GPs to appreciate their specific needs. It will also add to our knowledge of the complex relationship between gender, work and health.
Dymaxion++: A Directive-Based API to Optimize Data Layout and Memory Mapping for Heterogeneous Systems

There has been a growing trend in using heterogeneous systems with CPUs and GPUs to solve diverse compute problems. However, high application performance on these platforms relies on efficient memory accesses. For many applications, CPUs and GPUs prefer different memory mappings and data structure layouts. This in turn requires developers to use device-specific strategies for memory access optimizations. Achieving both code and performance portability becomes a challenge for heterogeneous computing. This paper proposes a directive-based API, Dymaxion++, which enables programmers to optimize memory access patterns across devices with a simple interface. Use of Dymaxion++ requires only minimal modifications to existing codes with a small set of pragma extensions. The current framework augments the original Dymaxion framework with a clean abstraction backed by a source-to-source code translator. Dymaxion++ also provides additional programming features to map data structures to GPU's hybrid memory spaces (e.g. texture and constant memory) for different uses. Additionally, data layout transformation is enabled while exchanging data between GPU scratchpad and device memory as well as between system memory and device memory.
DOUBLE-FRONTED FURNITURE FACADE AND MOUNT USED WITH SAME

A facade having two front faces is intended for changing the consumer characteristics of furniture as a result of switching the outer front surface thereof during use. The front faces of the facade are made of metals, glass, polymer materials, composite materials and wood-containing materials capable of being combined with one another using mechanical, thermal and chemical methods of processing, both of each side individually, and jointly. The facade is primarily held along the lateral sides thereof by means of a detachable connection between a concealed mechanism and the mount, which is in turn affixed to a furniture accessory mechanism which allows for a movable connection between the facade and the furniture body. The front surface of a piece of furniture is changed following the spatial displacement of the facade relative to the static position thereof, wherein at least two variants of overall facade surface characteristics are achieved for a set of furniture as a whole. The invention allows for using a furniture facade without affixing furniture accessory mechanisms along either of the available front faces.
Serving base‐of‐the‐pyramid markets: meeting real needs through a customized approach

Purpose – This article aims to propose a continuum of strategic engagement approaches to base‐of‐the‐pyramid (BOP) markets ranging from non‐profit and government aid to corporate social responsibility (CSR) programs and social entrepreneurship. A framework is presented to identify which approach to serving the BOP market makes the most sense under certain conditions, depending on availability of consumer resources to participate in the initiative, the infrastructure available for the initiative to leverage, and whether the focus of the initiative is to be self‐sustaining over time.Design/methodology/approach – This is a conceptual article based on literature review and synthesis.Findings – Eight different approaches to engage with BOP markets are recommended under different combinations of three underlying conditions: consumer resources, infrastructure availability and self‐sustainability goals.Originality/value – The paper presents a continuum of strategic engagement approaches to BOP markets.
Aging behavior and electrical properties of low-temperature sintered (Ba, Ca)(Ti, Zr)O 3 -Ba(Cu, W)O 3 ceramics and plate loudspeaker

Abstract Lead-free (1 −  x )wt.% (Ba 0.85 Ca 0.15 )(Zr 0.10 Ti 0.90 )O 3  −  x  wt.% (Ba(Cu 0.5 W 0.5 )O 3 (BCZT −  x  wt.% BCW) piezoelectric ceramics were prepared by solid-state reaction. The phase structure of the ceramics showed that the orthorhombic–tetragonal phase boundary was identified in the range of 1.2 ≤  x  ≤ 1.6 wt.%. The dense microstructure and optimal electrical properties of the ceramics were obtained at x  = 1.2 wt.%. Fatigue behavior of the ceramics was also investigated as a function of temperature and keeping time, where the BCZT − 1.2 wt.% BCW materials were found to possess improved fatigue characteristic. In addition, the sound pressure level (SPL) of 16.0 mm length × 16.0 mm width × 0.1 mm piezoelectric loudspeakers using lead-free BCZT ceramics with 1.2 wt.% BCW content at drive voltage of 10–20 V was more than 80 dB at frequency of 2.2–20.0 kHz. These results indicated that the 98.8 wt.% BCZT − 1.2 wt.% BCW ceramics was potential for piezoelectric loudspeaker applications.
Lewy Body Dementia

Lewy body dementia (LBD) is a common cause of dementia but to date, little is known about caregiver burden. The Lewy Body Dementia Association (www.LBDA.org) conducted a web-based survey of 962 caregivers (mean age 56 y; 88% women). The most common initial symptoms were cognitive (48%), motor (39%), or both (13%). Caregivers expressed concerns about fear of future (77%), feeling stressed (54%), loss of social life (52%), and uncertainty about what to do next (50%). Caregivers reported moderate-to-severe burden; 80% felt the people around them did not understand their burden and 54% reported feelings of isolation with spousal caregivers reporting more burden than nonspousal caregivers. Only 29% hired in-home assistance, whereas less than 40% used respite or adult day care, geriatric case managers, or attended a support group meeting. Lack of service utilization occurred despite two-thirds of caregivers reporting medical crises requiring emergency services, psychiatric care, or law enforcement. Caregivers reported preferences for web-based information, directories of LBD expert providers, information on LBD research, and location of local support groups. These findings highlight significant unmet needs for LBD caregivers and provide targets for intervention to reduce caregiver burden. Community resources such as the Lewy Body Dementia Association may serve this end, while also providing practical information and support for caregivers.
Swimming Speed of Larval Snail Does Not Correlate with Size and Ciliary Beat Frequency

Many marine invertebrates have planktonic larvae with cilia used for both propulsion and capturing of food particles. Hence, changes in ciliary activity have implications for larval nutrition and ability to navigate the water column, which in turn affect survival and dispersal. Using high-speed high-resolution microvideography, we examined the relationship between swimming speed, velar arrangements, and ciliary beat frequency of freely swimming veliger larvae of the gastropod Crepidula fornicata over the course of larval development. Average swimming speed was greatest 6 days post hatching, suggesting a reduction in swimming speed towards settlement. At a given age, veliger larvae have highly variable speeds (0.8-4 body lengths s(-1)) that are independent of shell size. Contrary to the hypothesis that an increase in ciliary beat frequency increases work done, and therefore speed, there was no significant correlation between swimming speed and ciliary beat frequency. Instead, there are significant correlations between swimming speed and visible area of the velar lobe, and distance between centroids of velum and larval shell. These observations suggest an alternative hypothesis that, instead of modifying ciliary beat frequency, larval C. fornicata modify swimming through adjustment of velum extension or orientation. The ability to adjust velum position could influence particle capture efficiency and fluid disturbance and help promote survival in the plankton.
Alteration of Light-Dependent Gene Regulation by the Absence of the RCO-1/RCM-1 Repressor Complex in the Fungus Neurospora crassa

The activation of transcription by light in the fungus Neurospora crassa requires the White Collar Complex (WCC), a photoreceptor and transcription factor complex. After light reception two WCCs interact and bind the promoters of light-regulated genes to activate transcription. This process is regulated by VVD, a small photoreceptor that disrupts the interaction between WCCs and leads to a reduction in transcription after long exposures to light. The N. crassa RCO-1/RCM-1 repressor complex is the homolog of the Tup1-Ssn6 repressor complex in yeast, and its absence modifies photoadaptation. We show that the absence of the RCO-1/RCM-1 repressor complex leads to several alterations in transcription that are gene-specific: an increase in the accumulation of mRNAs in the dark, a repression of transcription, and a derepression of transcription after long exposures to light. The absence of the RCO-1/RCM-1 repressor complex leads to lower VVD levels that are available for the regulation of the activity of the WCC. The reduction in the amount of VVD results in increased WCC binding to the promoters of light-regulated genes in the dark and after long exposures to light, leading to the modification of photoadaptation that has been observed in rco-1 and rcm-1 mutants. Our results show that the photoadaptation phenotype of mutants in the RCO-1/RCM-1 repressor complex is, at least in part, an indirect consequence of the reduction of vvd transcription, and the resulting modification in the regulation of transcription by the WCC.
Optimization two phases cooling solution using micro pump brick

Traditionally, aeronautical power electronics use liquid and/or air forced cooling systems. These techniques are proven, reliable and robust technology but drawbacks are overweight and limited efficiency to extract heat flow generated in high power and dense converters.
This call for proposal consists of studying and developing demonstrators of cooling system based on pumped two-phase techniques in order to reduce drastically thermal constrains, weight and dimensions of high dense power electronics modules. This cooling technique, initially developed for space application, becomes a promising solution for the More Electric Aircraft (MEA) concept that allows for densification and growth of on-board power without overweight or thermal issues.
This CfP is a scientific and industrial challenge, which provides opportunity of competitiveness on this important improvement part of power electronics dedicated for more electrical aircraft for European partners of Clean Sky.

In TOPMOST, three demonstrators of a two-phase pumped system will be built. Key components of the demonstrators will be manufactured with 3D metal printing, which results in lightweight and efficient systems. Two of the demonstrators will be delivered to the Topic Leader Thales, and one demonstrator will be used for extensive qualification tests. The Technology Readiness Level (TRL) of the demonstrators will be 5 at the end of the project.
HOLA SRL DENTAL

HELLO DENTAL SRL ES UNA JOVEN EMPRESA LIGURIA QUE GESTIONA UN CONSULTORIO DENTAL UBICADO EN GÉNOVA EN EL DISTRITO DE MARASSI. LA MISIÓN DE LA COMPAÑÍA ES PROPORCIONAR SERVICIOS DENTALES DE CALIDAD A UN PRECIO ASEQUIBLE A GRANDES SECTORES DE LA POBLACIÓN. PARA LLEGAR AL MAYOR NÚMERO POSIBLE DE PERSONAS, LA UBICACIÓN DE LA ACTIVIDAD SE HA POSICIONADO EN LA CARRETERA, TAMBIÉN CON EL FIN DE FACILITAR EL ACCESO A LAS PERSONAS CON DISCAPACIDAD Y A LAS PERSONAS CON DISCAPACIDAD. EL PROYECTO, POR AHORA LIMITADO A UN SOLO LUGAR, PREVÉ EN UN FUTURO PRÓXIMO LA APERTURA DE NUEVAS UBICACIONES QUE PERMITIRÁN UNA EXPANSIÓN DE LA ACTIVIDAD ECONÓMICA.
Hiv-1 acquisition and the future of prevention strategies: deciphering the eclipse phase through modelling and phylogenetics

The HIV eclipse phase typically refers to the time between a virus entering a sexually exposed person and detection of viral RNA in their plasma. Of the four phases of HIV-1 infection (eclipse, acute, chronic and AIDS), the eclipse phase is currently the only window of opportunity for viral clearance. Systemic infection is currently irreversible after the onset of the acute phase. Preventing systemic HIV infection after exposure, therefore, requires understanding and targeting the eclipse phase. Information on this phase, however, is partial and indirect, with fundamental gaps in our knowledge of its role in limiting transmission, in determining the efficacy of infection control strategies, and in governing later infection. 

Mathematical modelling, when combined with statistical inference, is a useful tool for hypothesis testing and prediction using incomplete information. To date, however, there are no mathematical models that are particularly suitable because current models do not account for two important characteristics of eclipse phase infection. First, none of these models reconcile the very small per-exposure HIV-1 acquisition probability with the high estimate of the basic reproductive number, R0, during acute phase infection. Second, models of acute phase plasma viral load obscure early local dynamics of HIV when the virus forms local, heterogeneous clusters of infection in the genital mucosa before entering the lymphatic and blood systems. 

My research programme will develop novel models of HIV that are calibrated to diverse data sources to ascertain whether eclipse phase dynamics determine the acquisition of HIV and later infection dynamics. I will use phylogenetic analysis of HIV samples to quantify the role of the transmitting partner in determining viral inoculum dose size, eclipse phase dynamics and HIV acquisition. This research will generate testable predictions for exposed populations and aim to propose novel methods for infection prevention.
Vertical-cavity surface-emitting laser array

Disclosed is a method for controlling the emission wavelength of a vertical-cavity surface-emitting laser through the lateral mode size to achieve optical signal generation from two or more devices at two or more distinct wavelengths.
Design and kinematic simulation of clip seedling mechanism for an onion seedling transplanter

At present,transplantation of onion is done artificially in china,which causes labor-intensive,low productivity,poor quality planting and high production cost.In order to improve the efficiency of onion transplantation,a clip seedling mechanism was designed for transplanter of onion seedling.First,design calculations and theoretical analysis of clip seedling mechanism were carried on.And a 3-D parametric model and kinematic simulation of clip seedling mechanism were built up with Pro/E.Curve fitting and data analysis were built up with MATLAB.Then structure and motion parameters of the mechanism were optimized.The results show that the three main factors,influencing the effect of transplantation,are the range of motion of clip seedling mechanism,the opening-closing scope of opening-closing fixture and speed ratio of the lifting cylinder to telescopic cylinder.The corresponding parameters got by optimization are 0-53.3 mm,0-27.8 mm and 1.0,respectively.Feasibility of program for the clip seedling mechanism is verified.This article provides a theoretical support for the design and testing of transplanter of onion seedling.