SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Using cell-cell interactions to unlock new cancer treatments: forcing neural crest tumors back onto the developmental path

The interactions between tumor and its microenvironment are often critical to uncovering the mechanisms of tumor survival. A striking example is the recent success of immunotherapy approaches that expose tumor cells to immune attack by disrupting a specific interaction between the tumor and infiltrating lymphocytes.  The tumor can also repress immune response by inducing complex interactions among dozens of immune and stromal cell types that typically make up tumor microenvironment, however those remain largely uncharacterized as we currently lack systematic approaches to uncover relevant cell-cell interactions. The alternative to killing tumor cells, either directly or through immune system, is to force them to differentiate. Such strategy is particularly promising for tumors arising due to failure of progenitor populations to follow proper differentiation cascade. Here as well, the progress has been limited by lack of understanding of specific intercellular signals that that are disrupted in tumorigenesis. 
We propose a systematic approach for characterizing cell-cell interactions in complex microenvironments through joint analysis of spatially-resolved and disassociated single-cell transcriptomics. We will apply it to identify inter-cellular signals and pathways that can push tumors of neural crest origin, including as pheochromocytoma (PCC), paraganglioma (PGL) and neuroblastoma (NB), towards terminal differentiation. Building on our expertise with neural crest development, we will use single-cell profiling to map individual tumor cells onto developmental trajectory of neural crest differentiation. Spatial transcriptomics analysis will then be used to identify the sources and nature of microenvironment signals that channel neural crest differentiation during normal development. Contrasting interactions in normal and tumor tissues we will then aim to identify factors, pathways or signals that would push that PCC, PGL and NB tumors towards benign state.
A prelminary look at PPPs in the nexus of water-energy

This study reviews the success factors of public-private-partnerships (PPPs) and proposes a new success factor, ‘impact on product,’ as a result of a review of six large, mostly multi-national companies' PPP work in the area of the nexus of water and energy. Based on a preliminary research, it concludes that the ‘impact on product’ has potential to have a high weight in a company's decision-making process as it considers PPP possibilities with different NGOs. This may result in fewer number of but more successful PPPs from the private sector's perspective, but it may also help NGOs reconsider and refine their value propositions as they attempt to kick off and continue partnerships with the private sector.
Energy savings in residential buildings using a modular platform to control an all-in-one unit for water heating, climate control, and ventilation

To improve energy efficiency, modern “zero-energy” homes are highly insulated. As a consequence homes can no longer ventilate resulting in poor indoor air quality. Thus, the use of efficient ventilation is becoming increasingly important. But ventilation causes significant heat loss, reducing the energy-efficiency of the building. Although advances in last years, current trends in energy systems for climate control and water heating in residential buildings are still unsustainable and
further energy savings are fundamental.

Significant energy savings can be achieved by combining: (1) an AHU with a heat exchanger and (2) a heat pump to heat
water, in a single unit (COMBI-AHU). To reach the household market, COMBI-AHU systems must be re-engineered. The key
is an optimized electronic control system for higher efficiency to allow the unit to generate more heat per m2. LS Control,
leveraged by its high expertise in electronics, developed a set of cutting edge algorithms and electronic parts to control a
COMBI-AHU, allowing disruptive results in terms of efficiency. SmartCOMBI project will contribute to the EU Energy goals
by: improving the energy efficiency (COP increase by 25-35%); decrease the energy wastage (>95% of energy recovered);
Decrease the GHG emissions.

The SmartCOMBI project aims to optimize and demonstrate a novel and cost-effective control platform, resulting in cost
savings and benefits for end-users (lower running and installation costs, optimized comfort and healthier environment; better
control of expenses – web user interface) and manufacturers (faster route to market and lower customization cost;
certification and high energy labels; gain competitive advantage by offering high efficient and cutting edge technology,
otherwise impossible due to lack of know-how or financial capacity). The development and market uptake of the AHU
Control 2020 will put LS Control as leading technology suppliers and developers for COMBI-AHU solutions for households.
EFFLUENT TREATMENT

A method of treating photographic effluent by precipitating or otherwise removing harmful pollutants to provide an environmentally acceptable liquid phase and a disposable solid phase. The pollutants are removed from the effluent by the addition of chemical reagents which sequentially cause different pollutants or their derivatives to precipitate. A time delay may be necessary between certain additions to allow completion of that reaction and prevent interference from other reactions. The method is preferably carried out in a single vessel.
Akt1 Enhances CA916798 Expression through mTOR Pathway

Multi-drug resistance leads to the failure of chemotherapy for cancers. Our previous study showed that overexpression of CA916798 led to multi-drug resistance. However, the underlying mechanisms remain unknown. In the current study, we observed that the levels of phosphorylated AKT, phosphorylated mTOR and CA916798 all increased in the drug resistant human adenocarcinoma samples and paralleled with the change of drug resistance. The results of immunofluorescence and Co-IP indicated that the positive correlation of CA916798 expression with AKT1 activation might be associated with drug resistance of lung adenocarcinoma. Furthermore, AKT1 stimulated CA916798 expression through mTOR pathway in both A549 and A549/CDDP cell lines, which was also observed in the xenografted tumor in nude mice. The results showed that CA916798 located in the downstream of PI3K/AKT/mTOR pathway. Inhibition of PI3K by LY294002 could efficiently reduce CA916798 expression and tumor size in vivo as well. Additionally, LY294002 combined with rapamycin inhibited CA916798 expression and tumor size stronger than LY294002 alone. Our findings may also provide a new explanation for synergistic anti-tumor effects of PI3K and mTORC1 inhibitors.
Pulse excitation to continuous-wave excitation in a low-dimensional interacting quantum system

Real-time dynamics in one-dimensional transverse Ising model coupled with the time-dependent oscillating field is analyzed by using the infinite time-evolving block decimation algorithm and the Floquet theory. In particular, the transient dynamics induced by the pulse field and their connections to the dynamics by a continuous-wave field are focused on. During the pulse-field irradiation, the order parameter shows a characteristic oscillation, in which the frequency shifts from the pulse-field frequency. This is considered as a kind of the Rabi oscillation, but the frequency strongly depends on the intersite Ising interaction. After turning off the pulse field, the oscillation remains with a frequency $\mathit{\Omega}$ and a damping constant $\gamma$. In the case of low fluence, both $\mathit{\Omega}$ and $\gamma$ are scaled by the pulse amplitude in a wide range of the parameter values of the model. In the case of high fluence, $\mathit{\Omega}$ and $\gamma$ are arranged by a product of the pulse amplitude and the pulse width. This implies that the dynamics after turning off the pulse field are decided by a population of the excited state when the pulse field is turned off.
Cronología, bioestratigrafía y paleoecología del Pleistoceno Medio de galería (Sierra de Atapuerca, España)

El yacimiento de Galería es uno los rellenos cársticos pleistocenos situados en la Trinchera del Ferrocarril de la Sierra de Atapuerca. El relleno sedimentario se divide en seis unidades estratigráficas (GI a GVI). La base de la sucesión estratigráfica corresponde al Pleistoceno Inferior y es estéril. Las unidades fosilíferas con evidencias de ocupación humana (GIT y GITT) son de la segunda mitad del Pleistoceno Medio. Las especies de mamíferos permanecen evolutivamente estables; solo se observan cambios menores en los roedores Iberomys breccensis, Microtus aff. arvalis y Arvicola sp. No obstante, se detectan variaciones en las frecuencias de micro- y macrovertebrados y en las comunidades de aves. La subunidad Glla se interpreta como formada durante una fase cálida.
Immunological incompatibility as a basis for cancer curing and vaccination

In the ULISES project, we aim at developing an immunologic-based treatment strategy where cancer cells are “reprogrammed” to become “visible” to the patient’s own immune system, which will see them as “not belonging to the body” and will attack them, emulating the allogenic response to incompatible transplants. Thus, it will constitute a “natural” treatment, as the patient’s own immune system will be used to attack cancer cells, with no drugs, chemotherapy, radiotherapy, transplants, etc., significantly reducing the treatment time to few weeks and producing minimal or almost null side effects. In addition, this “reprogramming” will lead to an “immunological-memory” avoiding future relapses (vaccine-like effect) through TIL (Tumour Infiltrating Lymphocytes) generated around the tumour microenvironment by the immune system.
Porous nanoparticles (NPs) will be used as carriers for delivering a plasmid DNA cargo into the tumour cells in order to produce that “reprogramming”. These NPs will specifically recognize the cancer cells through the CD47 protein and the folate receptors beta and alpha, highly expressed on the surface of the cells. Moreover, two messenger RNAs will be used in order to avoid the side effects caused by targeting CD47 protein (mainly anaemia, neutropenia and thrombocytopenia).
Finally, highlight that the ULISES therapeutic strategy will be a “global” treatment, since only with 3 subtypes of NP (one for each chosen alloHLA-A), we will be able to target the entire population for each cancer type. For the implementation and validation of this strategy, we will focus on pancreatic cancer because of its high aggressiveness, lack of effective treatments and little life expectancy, but the developed strategy will also be valid for other cancer varieties with minimal modifications.
Modification of a static steam retort for evaluating heat transfer under reciprocation agitation thermal processing

Abstract A lab-scale reciprocating agitation retort was developed by modifying an existing conventional vertical static retort to include a reciprocating mechanism consisting of: (i) a reciprocating cage; (ii) a slider-crank assembly; and (iii) a permanent magnet motor. Mechanism was provided to control the amplitude (3–30 cm) and frequency of reciprocations (0–5 Hz). 307 × 409 cans filled with 80% glycerin to 10 mm headspace and equipped with a single particle were processed under different operating temperatures (110–130 °C), frequencies (0–4 Hz) and amplitudes (5–25 cm). Heat transfer analysis of the system revealed a very uniform and rapid heating scenario with 52–87% reduction in the equilibration time of the cold-spot and 2–7 times enhancement in the values of heat transfer coefficients. Consequently, process time required to achieve lethality of 10 min, reduced from 45 min to 17–24 min. Reciprocation processing also resulted in 26–36% reduction in quality-deterioration index (cook-value/lethality), showing potential to deliver high quality products.
Neutron production with a pyroelectric double-crystal assembly without nano-tip

Abstract Two cylindrical LiTaO3 crystals facing each other's deuterated circular face were exposed to deuterium gas at an ambient pressure of a few mTorr. With a distance of about 4 cm between the z+ and z− cut crystal faces, neutrons were produced via the 2H(d,n)3He fusion reaction upon the heating and cooling of the crystals. The 2.5 MeV neutrons were detected with organic liquid scintillation detectors equipped with neutron-gamma pulse-shape discrimination electronics to reject pulses generated by the intense X-ray flux. During the cooling phase of naked crystals, deuterium ion-beam (D2+) energies of up to 400 keV were obtained as deduced from the associated electron bremsstrahlung end-point energy. The highest electron-beam energy observed during the heating phase was 360 keV. With a layer of deuterated polyethylene evaporated on the front face of the crystals, the maximal energies were about 10% lower. In contrast to earlier studies, an electric-field enhancing nano-tip was not employed. Neutron yields up to 500 per thermal cycle were observed, resulting in a total neutron production yield of about 1.6×104 neutrons per thermal cycle. Our approach has the potential of being substantially improved by reducing the frequency of the discharges we are currently experiencing with our geometry, which was not designed for the unprecedented high potentials produced in the presentwork.
Antismoking Media Campaign and Smoking Cessation Outcomes, New York State, 2003-2009

The New York Tobacco Control Program (NY TCP) is one of the largest state tobacco control programs in the United States. Little research has been published on the effectiveness of its antismoking media campaign. The objective of this study was to examine whether exposure to NY TCP's statewide antismoking media campaign corresponded to smoking outcomes.We used data from the 2003 through 2009 New York Adult Tobacco Survey to evaluate exposure to NY TCP advertising, cessation intentions, quit attempts, and cigarette consumption among New York adult smokers. We also used data from the 2003 through 2009 New York Behavioral Risk Factor Surveillance System (BRFSS) and the 2003 through 2009 National Health Interview Survey (NHIS) to examine smoking prevalence among New York adults compared with US adults.From 2003 through 2009, smokers' exposure to NY TCP advertising increased from 6% to 45%, the prevalence of 30-day intentions to quit increased from 26% to 35%, and the prevalence of quit attempts increased from 46% to 62%. Average cigarettes smoked per day decreased from 15 in 2003 to 11 in 2009. The New York BRFSS and NHIS both showed significant downward trends in adult smoking prevalence. The decline during this period was greater in New York (18%) than in the United States as a whole (5%).NY TCP's campaign generated significant increases in exposure to advertising over time that corresponded with changes in key cessation- and smoking-related outcomes. Findings suggest that NY TCP's sustained implementation of evidence-based cessation advertisements contributed to these changes.
Communication platform for tenders of novels transport networks - complete

The objective of the COMPLETE project is to optimize spending of public resources when purchasing network equipment and the related services. As a key approach towards this goal, the project proposes to create a common information platform for public procurers and support them in the procurement process by providing the organizational and technical expertise. Required information under such platform will be gathered from the biggest vendors of optical transport system equipment. Relations with mentioned key vendors need to be established, sustained and promoted. Such platform will significantly improve the quality of decisions taken by public procurers and in some cases would enable to conduct such procurement that previously would not have been possible due to various organizational and technological constraints (for example lack of access to specific technical information and roadmaps). Gathered and sustained information under the platform will be accurate, measurable and comparable as it would be easy for the reader to understand each vendor’s positioning regarding particular technical features. Project will directly coordinate procurement procedures in respect of optical network solutions for the National Research and Education Network environment and public entities. It will support public bodies in procurement procedures and indicate how the procurements can be synchronized with other European Commission programs. Another objective is to define common procurement procedures to help NRENs with the whole process of purchasing new optical networking equipment.

There is a number of Horizon 2020 program activities for research, innovation and entrepreneurship that are linked with the project. The results achieved under this project’s proposal will be especially useful for the following two ICT calls:
• ICT-27-2015
• ICT-36-2015
• ICT-06-2014
Synthetic supramolecular polymers as artificial extracellular matrix for stem cell expansion towards organoids.

One of the most urgent challenges in medicine is to devise new strategies for replacing organs. The most promising approach to tackle this limitation is the use of stem cells. These cells have the capacity to proliferate and to differentiate into mature cells of various types. In fact, embryonic stem cells can become any organ, therefore, in principle, stem cells could be used to replace any part of the body. The fate of stem cells is governed by the microenvironment they foster, which offers the main point of control.  Unfortunately, the lack of an optimum extracellular matrix that closely mimics the in vivo microenviroments to promote differentiation of stem cells is the main limitation of this technology.
The SUPRAforORGANS uses a radically different strategy for designing an ideal artificial extracellular matrix. This approach consists of applying a dual network hydrogel formed by two different  synthetic supramolecular polymers. One of the polymers will form a stiff and fairly stable fibre that takes care of optimize the mechanical properties of the gel, and will have binding cell surface receptors required for cell expansion.  The second phase will be a weaker dynamic component in which biological cues are intercalated to bind and stabilize growth factors and other nutrients necessary for the cells to grow and organize into organoids. This matrix can actively be adapted by the cell, inducing both depolymerisation and reassembly to continuously support the growing organoids. Furthermore, some of cell receptors will be protected with photo-labile groups to possess user-defined spatio-temporal control, thereby this could control the three-dimensional growth of the organoid.
Streamlining Networking and Management efforts in Mediterranean Protected Areas for Enhanced Natural Conservation and Protection

PANACeA is a horizontal project that focuses on the specific objective 3.2. “maintaining biodiversity and natural ecosystems through strengthening the management and networking of protected areas”. 
It defines a mechanism to increase the visibility and impacts of thematic projects’ results towards common identified targets through the specific activities: 
1) Synthesizing outcomes on natural protection and biodiversity conservation efforts;
2) Engaging a stakeholders’ community and transferring knowledge beyond the project´s lifetime, 
3) Implementing a communication and dissemination strategy, 
4) Developing a long term capitalization tool ensuring evidence based policy enforcement.
The activities ensure an active community of Mediterranean actors meant to overcome sectoral borders by integrating knowledge, allowing a better informed multilevel decision-making on and management of biodiversity.
PANACeA supports the establishment of a two-way communication channel with the scientific community to ensure an effective policy-science interface in the Mediterranean related to biodiversity protection and sustainable development.
It ensures a long term strategic goal of the Interreg MED programme by creating impacts beyond the EU Member states & in the Mediterranean basin as a whole. It contributes to the implementation of both EU and UNEP/MAP Barcelona Convention policies in the domains of protection and conservation of biodiversity and natural resources, in protected areas.
TRANSPARENT PANEL SYSTEM FOR PARTITIONS

A window assembly for partition walls. The window assembly includes a plurality of connector assemblies that are configured to be connected to a partition frame around an opening through the partition frame. Each connector assembly includes a base structure and at least one movable retainer that is biased towards an engaged position. The window assembly also includes a subframe including two pairs of elongated subframe members having opposite ends that are rigidly interconnected to define a generally rectangular central opening. The subframe further defines oppositely facing inner and outer side faces. The subframe includes a connecting portion protruding away from the inner side face and engaging the movable retainer to connect the subframe to the connector assemblies. The window assembly further includes at least one sheet of light-transmitting material secured to the subframe and extending across the central opening.
Functional and Phenological Complementarities Resulting from Vegetation Heterogeneity Increase Resilience of Ungulate Populations to Climatic Variability in Mediterranean Ecosystems

Mediterranean environments are characterized by strong intra- and inter-annual fluctuations in plant primary production, which are likely to regulate the carrying capacity and densitydependent responses of ungulate populations. These effects may, however, vary across spatial and temporal scales. Habitat heterogeneity, particularly when associated to differentiated phenological responses, may allow wild ungulates to mitigate temporal fluctuations in plant productivity by using different resources along the year. In this work, we use a 15-years dataset (including remote-sensing data on vegetation distribution, phenology and production, as well as ungulate population counts) to assess how temporal variability in plant primary production and livestock abundance influence the population dynamics of two wild ungulates: native red deer, Cervus elaphus , and introduced fallow deer, Dama dama . Results show that temporal alternation in the phenological cycles of the four different vegetation types increased plant production, thus food availability for ungulates, within each year. Furthermore, complementarity in the responses of different vegetation types to variations in the amount and timing of rainfall increased the predictability of food availability across different years. This complementarity effect was further increased by the contrasting responses of ungulate populations to variation in the production of different vegetation types. Furthermore, domestic ungulates had positive effects on wild ungulate density at low to intermediate abundances, but high livestock densities decreased ungulate density and constrained the resilience of the plant-ungulate system to the impact of climatic variation, particularly under climate change. Our findings deepen the knowledge on vegetation-ungulate interactions in Mediterranean areas, potentially contributing to develop better management strategies of ungulate populations and adapt them to ongoing climate change.