SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
LINC-24. Survival and genetic evaluation of patients diagnosed with choroid plexus tumor treated at a Brazilian institution

Abstract INTRODUCTION: Choroid plexus tumors (CPT) are rare intraventricular neoplasms of epithelial origin. They usually occur in the 2nd year of life, corresponding to 0.4-0.6% of intracranial tumors in this age group. They are classified, according to WHO 2021: choroid plexus carcinoma (CPC), atypical choroid plexus papilloma (ACPP) and choroid plexus papilloma (CPP). Li-Fraumeni syndrome (LFS) is present in 50% of patients with CPC. In Brazil, the TP53p.R337H mutation affects 0.3% of the population in the South/Southeast. OBJECTIVE: Evaluate the genetic assessment and overall-survival (OS) of patients with CPT treated at IOP/GRAACC/UNIFESP. PATIENTS/METHODS: Between 1995-2021, 48 patients were diagnosed with CPT in our institution, 27 CPC, 18 CPP and 3 ACPP. From 2012-2021 patients were referred for genetic evaluation, 16 of which had CPC (2 had previously CPP). Family history for neoplasms was present in 87.5%, 37.5% compatible with Li-Fraumeni Syndrome (LFS) of which 50% with positive mutations. The molecular investigation of TP53 gene in patients with CPC was performed and positive in 62,5%:R337H(6 patients), R110C*, R158H*, H179R*, R196* (*1 patient each). For those with R337H, p53 protein immunohistochemistry resulted in 90-100% positivity. Treatment strategies consisted of surgery with gross total resection being achieve in all ACPP, 94,4% CPP and 55,5% CPC. Chemotherapy was performed in only 1 case of ACPP and all CPC with a variety of schemas, including high dose of chemotherapy and autologous bone marrow transplant for slow responders or recurrent disease. The three- and five-years OS for CPC was 72.5% and 61.7%, respectively. For CPP and ACPP 5y OS was 100%. CONCLUSION: The present study is in agreement with the literature showing an excellent survival for CPP and ACPP but an inferior outcome for patients with CPC and TP53 mutation despite being assisted by a well-prepared multidisciplinary team with an adequate treatment.
Just noticeable differences in affect: estimating the minimum change in positive and negative affect that meaningfully impact people’s subjective experience of emotions

Positive and negative affect are two components of experienced emotions that are the foundation of our subjective well-being, with important influences on mental and physical health. Self-report measures have been developed to quantify positive and negative affect, which can then be statistically compared within or across groups. They are used as indicators of subjective well-being in large surveys of European populations and as outcome measures in thousands of research studies. We can establish whether there has been a statistically significant change in affect over time, or whether there is a statistically significant difference between people. But, using the results of surveys and research to shape social policies or medical treatments requires the answer to a crucial yet unanswered question: How much do measurements of change in affect reflect people’s meaningful experiences? 
One way to gauge the meaningfulness of a statistical change in affect is to determine whether people subjectively perceive the difference in their emotional experience—whether they feel different. The proposed project addresses this question using the just noticeable difference approach, from psychophysics, in a first ever application to estimate the minimum change in positive and negative affect that meaningfully impacts people’s subjective experience of emotions, also examining potential cross-cultural variability. 
Researchers, policy decision makers, and the public can use this project’s results to evaluate findings from surveys and research studies in terms of meaningfulness. The methods may be adapted for other fields interested in people’s subjective experience and used to estimate the smallest change in an outcome measure that may be considered meaningful.
The researcher has relevant expertise in the project’s domain and the host provides the perfect environment for the successful implementation of the research and training activities, ensuring the researcher’s career advancement.
Characterization of patients with angioedema without wheals: The importance of F12 gene screening

Sporadic and familiar forms of non-histaminergic angioedema and normal C1 inhibitor encompass a group of disorders possibly caused by bradikinin. We aimed to study the subgroups of hereditary angioedema with FXII mutation (FXII-HAE), unknown genetic defect (U-HAE) and idiopathic non-histaminergic acquired angioedema (InH-AAE). We screened the F12 locus in our cohort and delineated the clinical, laboratory and genetic features. Four families carried the p.Thr309Lys mutation in F12 gene. Haplotyping confirmed the hypothesis of a common founder. Six families were affected by U-HAE and 13 patients by sporadic InH-AAE. C4 levels were significantly lower in FXII-HAE than in InH-AAE. In the FXII-HAE group, none had attacks exclusively in high estrogenic states; acute attacks were treated with icatibant. Prophylaxis with tranexamic acid reduced the attack frequency in most patients. Our study provides new data on the diagnosis, clinical features and treatment of non-histaminergic angioedema, underlying the role of the screening for F12 mutations.
Opening a new window onto medieval glass trade and technology

This project will open a new window onto trade and contact in Early Medieval western Europe, applying multidisciplinary research methods to well-dated samples of glass to investigate its production, trade, and recycling from the 7th to the 10th centuries AD. Historical research at one of the leading centres for the study of the Early Medieval period will be paired with cutting-edge scientific analysis, allowing the first detailed mapping of the changing production technologies of glass in this period, the trade routes followed by different glass ‘recipes’, and the social and economic factors influencing practices such as recycling. While the chemical and isotopic analysis of glass is already used as a proxy for questions of trade and contact, the data currently available for this period are sporadic, with many samples coming from poorly-dated archaeological contexts. This is a vital period in the history of glass production, witnessing a major compositional transition from the use of natron to plant ashes in its manufacture, but the timing of this technological change – and its relationship with Early Medieval recycling practice – cannot be understood without better temporal resolution than is currently available. This project seeks to resolve these concerns by focusing upon closely-dated samples of glass from several western European countries (Ireland, Denmark, Norway, Sweden, Italy, and Spain), and by combining chemical analysis with archaeological and historiographical approaches. In tandem with the Digital Atlas of Roman and Medieval Civilisations (DARMC), Harvard University, this project will be hosted by the glass research group at Newcastle University (led by Duckworth), which has a particular focus on analytical chemistry and the investigation of recycling, and its results will feed into broader understanding of the development of the European economy after the Roman period.
Single molecule analysis in nanoscale reaction chambers

Single Molecule Analysis in Nanoscale Reaction Chambers

Imagine that you would measure the average eye color of the population in Sweden. Clearly it would not say much about the colors of the eyes of the inhabitants. To obtain this information, one must of course study them individually. The same holds true for complex biological molecules, especially proteins, which may exist in many different configurations that cannot be resolved in an ensemble measurement. Heterogeneities in biomolecular structure and function limit our understanding of biology. To advance further it is vital that we study biomolecules individually. For proteins this is highly challenging since it must be done in a non-invasive manner under conditions similar to their native environment.

The SIMONANO project aims to develop a new platform for single molecule analysis which provides essential advantages. Proteins will be controllably loaded into solid nanoscale chambers, thereby eliminating the need of field gradient forces or surface immobilization. Furthermore, the proteins are entrapped at physiological conditions and small ligands can still access them quickly. Most importantly, the content is regulated on the single molecule level, i.e. proteins can be controllably loaded one at a time and different types of proteins can be introduced sequentially. Advanced (but established) fluorescence microscopy techniques will be used to detect the proteins and analyze their reactions.

The possibility to reliably entrap any desired number of proteins under physiological conditions and study their reactions will provide great scientific advancements in the life sciences. Once developed in this project, the nanoscale reaction chambers can become a tool used by biologists worldwide, which will advance our understanding of life on the molecular level. This will in turn lead to new applications in biotechnology and medicine.
Holdings Concentration and Hedge Fund Investment Strategies

This article examines the risk–return performance of concentrated positions of hedge funds in large-cap and small-cap stocks. The research shows that small-cap stocks in which hedge funds have concentrated positions earn higher future returns than those that are not part of hedge funds’ concentrated holdings. Also, stocks that are part of the concentrated positions of hedge funds display higher downside risks and relatively large downside returns during periods of market turmoil. The results presented indicate that hedge fund managers are skilled in making equity investments under different degrees of market efficiency. The authors’ findings have two practical implications: (1) hedge funds that hold concentrated positions in small-cap stocks may outperform their peers and (2) investors may be able to improve the performance of their equity portfolios by monitoring hedge funds’ positions in small-cap stocks. TOPICS:Real assets/alternative investments/private equity, portfolio construction, performance measurement Key Findings • Stocks in which hedge funds have concentrated positions earn higher future returns and display higher downside risks than those that are not part of hedge funds’ concentrated holdings. • The above-mentioned effects associated with hedge funds’ concentrated positions are stronger for small-cap stocks than large-cap stocks. • Results imply that monitoring hedge funds’ positions, especially in small-cap stocks, may improve the performance investors’ equity portfolios.
Beyond “Conflict Minerals”: The Congo’s Resource Curse Lives On

January 6, 2014. It’s the opening night of the Consumer Electronics Show, and it seems as if the whole of Silicon Valley has descended on the Las Vegas Convention Center and Venetian hotel to peddle its wares. On the show floor, a company called Sensoria introduces a “smart bra” designed to accommodate fitness tracking technology, while rivals brandish other “wearables.” A startup called Parrot introduces its Jumping Sumo toy drone. Tractive unveils a dog remote. Tech gurus and A-list celebs celebrate the rise of the Internet of Things, with its data-crunching onesies and bottle warmers. As the night wears on, T-Mobile CEO John Legere, wearing a bright pink company T-shirt, crashes a swanky AT&T party, only to be kicked out fifteen minutes later. “I just wanted to hear Macklemore,” he tells a reporter.
METHOD FOR PRODUCING REGENERATED CELLULOSE-BASED THREADS AND FELTED CLOTHS

The present invention is directed to efficient methods for producing contiguous threads or felted cloths from recycled cellulose-based waste. The contiguous thread produced is suitable to be sowed on a cloth; it is small enough to go through the pore of a needle, it is strong enough to hold together, and it is bendable and not disintegrated into fragments. The contiguous thread and felted cloth made by the present invention maintain their original dye color of the recycled cellulose waste, and they do not need to be re-dyed.
Trade Dynamics in the East Asian Miracle: A Time Series Analysis of US–East Asia Commodity Trade, 1962–1992

This article examines the composition of bilateral trade between the United States and eight Asian Pacific economies from 1962 to 1992. Two complementary time series analyses of individual commodities at the SITC four-digit level indicate that significant changes occurred in trade composition during this period. It uses a measure of normalized trade balances, developed by Gagnon and Rose (1995). For the eight bilateral trade relationships, commodities representing 50 to 70 per cent of 1992 dollar trade have shown statistically significant changes in the magnitude and, in some cases, in the direction of normalized trade balances, over the 30-year period. Results support the conclusion that changes in trade patterns in both low-tech industries, such as textiles and clothing and more high-tech industries, such as electronic parts and electronic goods, were important in the development of the East Asian economies.
Automated crop field extraction from multi-temporal Web Enabled Landsat Data

An automated computational methodology to extract agricultural crop fields from 30 m Web Enabled Landsat data (WELD) time series is presented. The results for three 150 × 150 km WELD tiles encompassing rectangular, circular (center-pivot irrigation) and irregularly shaped fields in Texas, California and South Dakota are presented and compared to independent United States Department of Agriculture (USDA) National Agricultural Statistics Service (NASS) cropland data layer (CDL) classifications. Coherent fields that are visually apparent were extracted with relatively limited apparent errors of omission or commission compared to the CDL classifications. This is due to several factors. First, the use of multi-temporal Landsat data, as opposed to single Landsat acquisitions, that enables crop rotations and inter-annual variability in the state of the vegetation to be accommodated for and provides more opportunities for cloud-free, non-missing and atmospherically uncontaminated surface observations. Second, the adoption of an object-based approach, namely the variational region-based geometric active contour method that enables robust segmentation with only a small number of parameters and that requires no training data. Third, the use of a watershed algorithm to decompose connected segments belonging to multiple fields into coherent isolated field segments and a geometry-based algorithm to detect and associate parts of circular fields together. A preliminary validation is presented to gain quantitative insights into the field extraction accuracy and to prototype a validation protocol including new geometric measures that quantify the accuracy of individual field objects. Implications and recommendations for future research and large-area applications are discussed. • Fully automated crop field extraction method applicable to large areas • Object-based crop field extraction • Uses multi-temporal WELD data • High qualitative correspondence of field extractions with U.S. National Agricultural Statistical Service cropland data layer products. • New geometric measures to quantify the accuracy of individual field objects demonstrated.
WATER MIXER WITH LEVER HANDLE

A water mixer with mixer cartridge (40) with control element (42) and lever handle (31) operable from left to right to control the ratio water flow from respective hot and cold intakes to a single outlet (18), and about a transverse axis to control rate of flow. A mixer body (20) defines a post (22) and a protruding outlet arm (24) at its end. The body defines, at the aforesaid end of the post and extending into the arm, a rim (25) about a recess (26) that receives part of the lever handle in a central off position thereof. In another aspect, lever handle (31) is pivotally mounted to support (50, 150) at a first pivot (52,54) that is fixed against translation and to the control element of the cartridge at a second pivot (48) that is slidable in a slot (39).
CELAVIE

The project intends to make a contribution to the agriculture and aquaculture sector, particularly in the inland areas of the Sicilian and Tunisian territories, by providing an impetus focused on the innovation of processes and products. The project foresees the realisation of a system, a Vitale Cell, capable of combining the production of aquatic plants and animals in a single eco-sustainable and guaranteed cycle, characterised by a low cost, by not entering into conflict with other markets already bred, by supplying quality genetic material a km 

0.
Sobre a formação e o ensino policial: o que dizem as pesquisas?

O presente texto apresenta um estado do conhecimento a partir da análise de teses e dissertações brasileiras defendidas no período de 2004 a 2016, e tornadas públicas até 2018, no âmbito dos Programas de Pós-Graduação Brasileiros, e relacionadas com a temática “Formação e Ensino Policial”. Pretende-se, desta forma, evidenciar um panorama geral sobre este debate emergente em torno do Ensino Policial, projetado a partir das bases curriculares para formação do profissional de segurança pública, no campo da produção acadêmica brasileira. O estudo baseou-se numa abordagem qualitativa com aplicação da pesquisa bibliográfica. Os resultados revelaram que as pesquisas sobre “Formação e Ensino Policial” foram ampliadas nacionalmente ao longo dos anos e vem ganhando forma específica nos Programas de Pós-graduação em Educação no Brasil, evidenciando as categorias presentes nas Teses e Dissertações, tais como: Formação Policial, Currículo, Educação Policial, Ensino Policial, Prática Docente, Identidade Profissional, Ensino Militar, Sistema de Ensino e Profissionalidade Docente, e possibilitando uma visão geral do que vem sendo produzido em torno da temática Formação e Ensino Policial. Pode-se concluir que esses estudos vêm impulsionando o debate sobre a superação da instrução militar no sentido de se estabelecer as bases de um ensino policial para formação do profissional de segurança pública com aproximações da função docente no aclamado Ensino Policial.
Collaborative network for training and expertise in psychotraumatology

Mental health disorders afflict more than one-third of the EU’s population each year with an annual economic cost to the EU of €432 billion. The ‘COllaborative Network for Training and EXcellence in psychoTraumatology’ (CONTEXT) is an international, interdisciplinary European Industrial Doctorate (EID) designed to address deficiencies in psychotraumatology training and innovation. A key feature of CONTEXT is the minimum 50% secondment of each ESR to the non-academic sector. Consistent with the requirements of an EID, this component grants ESRs access to populations not otherwise accessible in standard doctoral training programmes. This design will facilitate a new cohort of researchers and practitioners who can translate research into practice, thereby mitigating the impact of psychotrauma in the EU. The goal of CONTEXT is to develop a high quality, innovative research training programme to build capacity and expertise, and foster innovative practice and social enterprise in the area of psychotraumatology. The nine beneficiaries of CONTEXT represent a diverse, interconnected, intersectoral consortium, well placed to collaboratively train and supervise the 12 ESRs. Three interconnected research work packages, each targeting a priority population in Europe (EU-based asylum seekers and refugees, WP3; emergency-service personnel and humanitarian first-responders, WP4; and victims and perpetrators of childhood- and gender-based violence, WP5), address current and emergent skill and professional deficiencies that are essential in curbing the adverse social consequences of trauma-related psychological distress within the EU. CONTEXT enjoys significant support and commitment from highly regarded, international stakeholders and influencers at the political, scientific, and professional level.
One Belt, One Road, One World: Where is US Business Connectivity?

Chapter 4 examines US business connectivity with China’s Belt and Road Initiative (BRI) and provides insights into global cooperation between the world’s two largest economies in the emerging digital age. Informed by resource-based and institutional views, the analysis shows how potential US connectivity to the current BRI could provide windfall gains for US firms possessing competitive ownership advantage, with the advent of the Cyber/Digital and Maritime Silk Roads. This analysis also reveals potential costs and risks with such an involvement in the uncertainty of USA–China bilateral relations. Notwithstanding geopolitical differences, nation-state boundaries, resurgent protectionist movements, and regional markets, BRI partner countries are likely to experience much deeper connectivity as a result of intensifying international trade and investment integration, and concomitant cyberspace developments in countries such as the USA and China.
[The late sodium current: pathophysiology and pharmacology of a new therapeutic target].

The sodium current (INa) plays a pivotal role in the propagation of electrical activity in the heart. However, a large body of evidence indicates that the "late" component of INa (INaL) may be enhanced in diseased myocardium. INaL enhancement has consequences on the electrical stability, contractile function and metabolism of cardiac myocytes, which may significantly contribute to disease progression. The possibility of blocking INaL selectively, that is to say without affecting the INa component involved in electrical propagation, has recently emerged. INaL has hence become a "therapeutic target", thus far clinically validated in the treatment of angina and arrhythmias but, as suggested by bench evidence, potentially relevant to a wider range of cardiac disorders. Such multiplicity of effects originates from the complex network of cell functions affected by INaL enhancement; acquaintance with such a network is useful in fully exploiting the therapeutic potential of selective INaL inhibition. This review deals with the pathophysiology of INaL enhancement and with the basic principles underlying its selective inhibition. Clinical evidence of antianginal and antiarrhythmic efficacy of INaL inhibition is available, but its discussion goes beyond the scope of this review.
Quantification of Risk Profiles and Impacts of Uncertainties as part of US DOE's National Risk Assessment Partnership (NRAP)

Abstract The National Risk Assessment Partnership (NRAP) is a US-Department of Energy (US-DOE) effort focused on developing a science-based methodology for quantifying risk profiles at geologic CO 2 sequestration sites. Risk profiles are calculated using an integrated assessment modelling (IAM) approach which treats a geologic CO 2 storage site as a system and uses a system modelling approach to predict time-dependent behaviour of the storage site. We have developed first generation risk profiles associated with a few key potential impacts due to CO 2 leakage from a sequestration reservoir, including change in groundwater quality in a shallow aquifer and return of CO 2 to the atmosphere.