SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Topography and associations of perivascular spaces in healthy adults: The Kashima Scan Study

We investigated whether the topography of MRI-visible perivascular spaces (PVS) is associated with markers of specific underlying small vessel disease, including cerebral microbleed (CMB) distribution, in neurologically healthy adults.We analyzed baseline data of an ongoing Japanese population-based cohort study. PVS were rated in the basal ganglia (BG-PVS) and centrum semiovale (CSO-PVS) on axial T2-weighted MRI using a validated rating scale (score 0-4). BG-PVS degree was classified as low (score <2) or high (score ≥2). CSO-PVS degree was classified as low (score <3) or high (score ≥3). Independent demographic, clinical, and imaging factors for high degree of BG-PVS and CSO-PVS were investigated.A total of 1,575 neurologically healthy adults were included (mean age 57.1 years, SD 9.7; 47% male). In multivariable analyses, high degree of BG-PVS (n = 212, 14%) was associated with deep or infratentorial CMBs (odds ratio [OR] 2.77, 95% confidence interval [CI] 1.62-4.74), a marker of hypertensive arteriopathy; by contrast, high degree of CSO-PVS (n = 357, 23%) was associated with strictly lobar CMBs (OR 2.49, 95% CI 1.35-4.61), which share risk factors with cerebral amyloid angiopathy. Both high degree of BG-PVS and CSO-PVS were associated with hypertension (OR 2.03, 95% CI 1.46-2.82 and OR 1.39, 95% CI 1.07-1.81, respectively), lacunes (OR 3.35, 95% CI 1.92-5.86; OR 1.83 95% CI 1.08-3.08), and severe white matter hyperintensities (OR 2.17, 95% CI 1.42-3.31; OR 1.35, 95% CI 0.93-1.96), but these associations were stronger for high degree of BG-PVS.In a neurologically healthy cohort, the associations of PVS differ according to their topography. PVS distribution may be useful for the early detection and classification of small vessel disease.
The Sacred Mountains: common heritage of values, laboratory for sustainable conservation and better tourist usability of cultural heritage

The project enhances the traditional construction knowledge and the use of local materials and craftsmen, analyzing the monumental complexes of the Sacred Mounts of Piedmont; intends to propose a working method for the conservation and enhancement of cultural heritage that is economically sustainable, repeatable, capable of empowering institutions, communities, professionals and can contribute to the revitalization of the cross-border territory. Experimental construction sites will be started with a combination of advanced diagnostics, innovative technical solutions and tradition, also to enhance good maintenance practices.
Medical Image registration using sparse coding and belief propagation

Recently, various medical imaging such as CT and MRI imaging has been used more and more widely in clinical and medical research. As a result, there is an increasing interest in accurately relating information in different images for diagnosis, treatment, and the sake of basic science. As images are typically acquired at different times and often by different modalities, registering (or aligning) one image with another is not a simple task in general and it success will affect the effectiveness and accuracy of all subsequent analysis. We propose an efficient medical image registration method based on sparse coding and belief propagation for medical CT imaging. We used 3-D image blocks as features, and then we employed sparse coding to find a set of candidate voxels. To select optimum matches, belief propagation was subsequently applied on these candidate voxels. The outcome of belief propagation was interpreted as probabilistic map between candidate voxels and source voxel. We compared with the state-of-the-art of medical image registration, MIRT and GP-Registration algorithm. Our objective results based on RMSE (Root Mean Square Error) are smaller than those from MIRT and GP-Registration. Our results also proved the effectiveness of our algorithm in registering reference image to source image.
Changing of optical absorption and scattering coefficients in nonlinear-optical crystal lithium triborate before and after interaction with UV-radiation

In current work optical properties of LiB3O5 (LBO) crystal with ultraviolet (UV) (λ= 266 nm) induced volume macroscopic defect (track) are investigated using novel piezoelectric resonance laser calorimetry technique. Pulsed laser radiation of 10 W average power at 532 nm wavelength, is consecutively focused into spatial regions with and without optical defect. For these cases exponential fitting of crystal temperature kinetics measured during its irradiation gives different optical absorption coefficients α1 = 8.1 • 10-4 cm-1 (region with defect) and α =3.9⋅10−4 cm-1 (non-defected region). Optical scattering coefficient is determined as the difference between optical absorption coefficients measured for opaque and transparent lateral facets of the crystal respectively. Measurements reveal that scattering coefficient of LBO in the region with defect is three times higher than the optical absorption coefficient.
A practical guide to intelligent image-activated cell sorting

Intelligent image-activated cell sorting (iIACS) is a machine-intelligence technology that performs real-time intelligent image-based sorting of single cells with high throughput. iIACS extends beyond the capabilities of fluorescence-activated cell sorting (FACS) from fluorescence intensity profiles of cells to multidimensional images, thereby enabling high-content sorting of cells or cell clusters with unique spatial chemical and morphological traits. Therefore, iIACS serves as an integral part of holistic single-cell analysis by enabling direct links between population-level analysis (flow cytometry), cell-level analysis (microscopy), and gene-level analysis (sequencing). Specifically, iIACS is based on a seamless integration of high-throughput cell microscopy (e.g., multicolor fluorescence imaging, bright-field imaging), cell focusing, cell sorting, and deep learning on a hybrid software-hardware data management infrastructure, enabling real-time automated operation for data acquisition, data processing, intelligent decision making, and actuation. Here, we provide a practical guide to iIACS that describes how to design, build, characterize, and use an iIACS machine. The guide includes the consideration of several important design parameters, such as throughput, sensitivity, dynamic range, image quality, sort purity, and sort yield; the development and integration of optical, microfluidic, electrical, computational, and mechanical components; and the characterization and practical usage of the integrated system. Assuming that all components are readily available, a team of several researchers experienced in optics, electronics, digital signal processing, microfluidics, mechatronics, and flow cytometry can complete this protocol in ~3 months.
Common best practices in spatial planning for the promotion of sustainable POLYcentric DEVelopment

Regional spatial planning policies and tools for spatial development play an important role when applying sustainable development principles as they are outlined in the European Spatial Development Perspective (ESDP), by the European Spatial Planning Observation Network (ESPON) or by the European Conference of Ministers Responsible for Regional Planning (CEMAT). These principles combine economic, environmental and social objectives. It is necessary to verify how the principles may be applied to spatial planning and how to assess current planning tools, especially in polycentric development, with regard to sustainability. POLY.DEV deals with the demand for increasing knowledge and for developing a common strategy towards principles of sustainable polycentric development in order to avoid extreme polarisation around few centres and marginalisation of peripheral areas. Moreover, natural and cultural heritage should be managed in a balanced way through participative decision-making processes. The regions involved in POLY.DEV want to promote sustainable spatial polycentric development as a tool for balancing development with environment and cultural heritage preservation. The project partners of POLY.DEV come from Central and South-Eastern Europe. Partnership members are regional, provincial and local administrative bodies, development agencies and universities. The partnership equally involves scientific and administrative bodies, consultants and operative units.
Studies of dielectric constant measurements at microwave frequency using mixing equations-The analyses on five rules

The microwave dielectric constants of ceramic dispersions in the polyethylene matrix are studied by five well-known mixture equations in this article. Three ceramic powders of fillers with various dielectric constants at 10 GHz are investigated. The experimental dielectric constant values of the mixtures are compared to the theoretical curves of the five mixing rules. The dielectric constants of pure ceramics are then estimated by these mixing laws from the dielectric constants of composites of various filler concentrations. The theoretical errors of estimations of rules are derived and analyzed. The most adequate mixture law(s) for measuring the dielectric constants of ceramic fillers will be recommended. © 2011 Wiley Periodicals, Inc. Microwave Opt Technol Lett 53:2481–2485, 2011; View this article online at wileyonlinelibrary.com. DOI 10.1002/mop.26357
Hygrophorus roseodiscoideus Bon &amp; Chevassut: Epitypification and Updated Biogeography of a Poorly Known But Widespread Thermophilous Species

Hygrophorus roseodiscoideus Bon & Chevassut: épitypification et mise à jour biogéographique d'une espèce thermophile méconnue mais répandue. Hygrophorus roseodiscoideus Bon & Chevassut est une espèce méconnue jusqu'ici supposée restreinte aux chênaies méditerranéennes d'Europe occidentale. À l'heure où les sciences naturalistes sont entrées dans l'ère phylogénétique, l'absence de séquence de référence pour cette espèce prive les mycologues, ainsi que les experts en écologie fongique, d'un outil d'identification fiable de ce taxon. Nous solutionnons ici ce problème en épitypifiant H. roseodiscoideus avec une récolte séquencée issue des environs d'Aix-en-Provence, d'où l'espèce a été initialement décrite. Nous présentons aussi ici plusieurs récoltes séquencées d'Europe centrale et du Liban, qui étendent considérablement la distribution biogéographique de l'espèce. Sur la base de ce travail, H. roseodiscoideus se présente comme une espèce morphologiquement bien typée, thermophile, associée aux chênes sur sol calcaire, distribuée tout au long de la côte nord de la Méditerranée, depuis l'Espagne jusqu'au Levant, mais colonisant aussi les chênaies les plus chaudes d'Europe centrale.
The JCST trainee survey: highlights of the first year's results

In July 2010, the Joint Commitee on Surgical Training (JCST) launched a review of its quality assurance functions, which included the development of a new survey specific to surgical trainees. The survey was developed in conjunction with the Confederation of Postgraduate Schools of Surgery and aimed to provide detailed information on the quality of surgical training in the UK and to standardise the information from the different schools of surgery, thereby allowing some comparison between training schemes and units. A 20-question survey was developed for all surgical specialties, while a more detailed survey with questions relating to curriculum delivery was piloted in core surgical training and paediatric surgery.
Method and apparatus for determining drilling paths to directional targets

A method and apparatus for recomputing an optimum path between a present location of a drill bit and a direction or horizontal target uses linear approximations of circular arc paths. The technique does not attempt to return to a preplanned drilling profile when there actual drilling results deviate from the preplanned profile. By recomputing an optimum path, the borehole to the target has a reduced tortuosity.
A Framework for End-to-End Simulation of High-performance Computing Systems

We present an end-to-end simulation framework that is capable of simulating High-Performance Computing (HPC) systems with hundreds of thousands of interconnected processors. The tool applies discrete event simulation and is driven by real-world application traces. It provides a semantically correct replay of MPI application traces and maintains reasonable simulation details of both the processors in general and the interconnection network in particular. Among other things, it features several interconnection network topologies, flexible routing schemes, arbitrary application task placement, point-to-point statistics collection, and data visualization. With a few case studies, we demonstrate the usefulness of this tool for assisting high-level system design as well as for performance projection and application tuning of future HPC systems.
Exact quantization of a superparticle inAdS5×S5

As a step toward deeper understanding of the AdS/CFT correspondence, exact quantization of a Brink-Schwarz superparticle in the AdS_5 x S^5 background with Ramond-Ramond (RR) flux is performed from the first principle in the phase space formulation. It includes the construction of the quantum Noether charges for the psu(2,2|4) superconformal symmetry and by solving the superconformal primary conditions we obtain the complete physical spectrum of the system with the explicit wave functions. The spectrum agrees precisely with the supergravity results, including all the Kaluza-Klein excitations. Our method and the result are expected to shed light on the eventual quantization of a superstring in this important background.
Efficient and Fine-Grained VMM-Level Packet Filtering for Self-Protection

In Infrastructure-as-a-Service (IaaS) clouds, stepping-stone attacks via hosted virtual machines (VMs) are critical for the credibility. This type of attack uses compromised VMs as stepping stones for attacking the outside hosts. For self-protection, IaaS clouds should perform active responses against stepping-stone attacks. However, it is difficult to stop only outgoing attacks at edge firewalls, which can only use packet headers. In this paper, we propose a new self-protection mechanism against stepping-stone attacks, which is called xFilter. xFilter is a packet filter running in the virtual machine monitor (VMM) underlying VMs and achieves pinpoint active responses by using VM introspection. VM introspection enables xFilter to directly obtain information on packet senders inside VMs. On attack detection, xFilter automatically generates filtering rules based on packet senders. To make packet filtering with VM introspection efficient, we introduced several optimization techniques. Our experiments showed that the performance degradation due to xFilter was usually less than 16%.
Central European Knowledge Platform for an Ageing Society

Fall of the working age population in Europe is becoming more apparent year by year with young people being slowly but surely outnumbered by people over 60. This obviously poses a number of challenges for the society.It is therefore important to adequately respond to "ageing challenges" using the potentials of older workers and capitalizing on the needs of an ageing society The Central European (CE) Knowledge Platform for an Ageing Society, in short “CE-Ageing Platform”, aims to minimise these negative effects and impacts of demographic change in Central Europe through transnational partnership. The project idea derived from cooperation between various partners and their desire to jointly contribute to improved framework conditions in their regions in order to foster economic growth, regional development and social cohesion. It is built on the belief that challenges faced in the cross-cutting issue "ageing" can only be solved in working together. The CE-Ageing Platform aims to jointly develop a CE-Ageing Strategy enabling partners to adapt to demographic change, thereby integrating lessons learnt from previous activities on the one hand and results and lessons learnt of innovative actions implemented by the CE-Ageing platform on the other.
Spreading whose word? transnational imams, religion and politics in turkey’s mosques abroad (france, uk, usa)

Since the early 2000s, Muslim Diasporas in Europe and the USA have raised a growing interest in the public and academic spheres. While building upon this interest, the proposed research aims to bring an original contribution to the field by adopting a transnational perspective that focuses on the religious policy of Turkey towards its diaspora. The study will concentrate on the imams sent to Europe and the USA to work in the mosques managed by the Turkish Directorate of Religious Affairs (Diyanet). The ethnographic study of these “transnational imams” aims to go beyond a state-centered analysis of Turkish religious policy abroad in terms of “soft power” or “religious diplomacy”. Instead, it proposes to evaluate the modalities and limits of this policy by concentrating on the training, motivations, mobility and achievements of these imams, as well as the ways they are perceived by different components of the Turkish diaspora, with special focus on France, the UK and the USA. The interdisciplinary approach at the crossroad of political science, sociology and anthropology will address the political and religious dimensions of the ideology conveyed by the Diyanet imams and question their impact on the Turkish communities settled abroad, in terms of religious practices, political affiliation, integration and possible radicalisation. The comparative perspective will take into account the history and social characteristics of these distinct Turkish diasporas and the different traditions of state/religion relationship in the three countries under study to analyse the strategies of the Diyanet and evaluate its results. Thus, by focusing on Turkey’s religious policy abroad, the proposed study aims to bring an original contribution on political Islam as a transnational ideology that mobilises state resources, religious establishments and local communities to spread a polymorphous political and religious discourse.
OSL, TL and IRSL emission spectra of sedimentary quartz and feldspar samples

Abstract This contribution presents a variety of different luminescence emission spectra from sedimentary feldspar and quartz samples under various stimulation modes. These are green stimulated quartz (OSL-) spectra, quartz TL spectra, feldspar IRSL and post-IR IRSL spectra. A focus was set at recording OSL and IRSL spectra at elevated stimulation temperatures such as routinely applied in luminescence dating. This was to test whether optical stimulation at elevated temperatures results in a shift of emission peaks. For OSL emissions of quartz, this has so far not been tested. In case of feldspar emissions, post-IR IRSL conditions, hence IRSL emissions at a low temperature, directly followed by high temperature post-IRSL emissions, are explicitly investigated. All spectra were recorded using a new system incorporated into a Lexsyg luminescence reader. Thus, this study, besides presenting new spectral data, also serves as a feasibility study for this new device. It is shown that (a) the new device is capable of automatically measuring different sorts of spectra, also at elevated temperatures, (b) known thermally and optically stimulated peak emissions of quartz and feldspar are confirmed, (c) obtained IRSL and OSL spectra indicate that there is no significant relation between peak emission and stimulation temperature.
TourScience

Tourscience aims to create a touristic offer based on scientific observations about climate change in the territory of Mont Blanc and Aosta Valley. Tourscience will project and develop scientific eco-tourism products in Mont Blanc's area in Chamonix and in the city of Torgnon (Aosta Valley). The touristic offer includes volunteering eco-tourism, through which the visitors will participate to data gathering and to observations on the effects of climate change, but also to the sensitization of other tourists on the issues related to environment and climate change.
Depois da dialética

PUCCIARELLI, Daniel. Materialismus und Kritik: Konzept, Aussichten und Grenzen des Materialismus um Ausgang von der Negativen Dialektik Theodor W. Adornos. Würzburg: Königshausen &amp; Neumann, 2019.
Educating the next generation of scientists in translational medicine: focus on eye diseases

Medicine today experiences a gap between basic research and successful clinical translation that delays establishment of urgently needed therapies. This is very clearly so in blinding retinal degenerations (RDs), where most are yet untreatable, even with a wealth of basic and pre-clinical research data available. To address this problem, transMed proposes an innovative programme to educate “translational researchers” that focuses on the bench-to-bedside development of treatments for RD.

The transMed consortium joins four academic groups (EKUT, UNIMORE, ULUND, HI) with four non-academic and SME partners (SPPD, INCU, Oculis, PamGene), and five partner organisations (2BBB, BIOLOG, NLO, HCTC, EVI) with intersectoral collaborations already ongoing. Each transMed partner will contribute specific critical expertise to a curriculum covering all major aspects of translational research: From basic research into disease mechanisms and target definition, to drug design and development, in vitro test systems and in vivo disease models, drug delivery systems, biomarkers, good manufacturing practice, toxicological testing and pharmacokinetics, regulatory affairs, intellectual property, all the way to clinical trials and commercialisation.

transMed builds on and integrates three relevant translational projects, which are at the early pre-clinical, late pre-clinical, and early clinical stages, respectively, to provide the project’s Early Stage Researchers with the broadest possible overview. The training is completed by e-lectures, the inclusion of dedicated conferences for young researchers, a secondment and hands-on course programme from industry to academia and vice versa, permitting further insight and networking in the European biotech industry. Altogether, transMed will offer its students the opportunity to obtain a competitive PhD degree in several critical areas of biomedical research, providing for a strong employability in both the private and public sector.