SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Fast endocytic recycling determines TRPC1–STIM1 clustering in ER–PM junctions and plasma membrane function of the channel

Stromal interaction molecule 1 (STIM1) senses depletion of ER-Ca2+ store and clusters in ER-PM junctions where it associates with and gates Ca2+ influx channels, Orai1 and TRPC1. Clustering of TRPC1 with STIM1 and Orai1 in these junctions is critical since Orai1-mediated Ca2+ entry triggers surface expression of TRPC1 while STIM1 gates the channel. Thus, plasma membrane function of TRPC1 depends on the delivery of the channel to the sites where STIM1 puncta are formed. This study examines intracellular trafficking mechanism(s) that determine plasma membrane expression and function of TRPC1 in cells where Orai1 and TRPC1 are endogenously expressed and contribute to Ca2+ entry. We report that TRPC1 is internalized by Arf6-dependent pathway, sorted to Rab5-containing early endosomes, and trafficked to ER-PM junctions by Rab4-dependent fast recycling. Overexpression of Arf6, or Rab5, but not the respective dominant negative mutants, induced retention of TRPC1 in early endosomes and suppressed TRPC1 function. Notably, cells expressing Arf6 or Rab5 displayed an inwardly rectifying ICRAC current that is mediated by Orai1 instead of TRPC1-associated ISOC, demonstrating that Orai1 function was not altered. Importantly, expression of Rab4, but not STIM1, with Rab5 rescued surface expression and function of TRPC1, restoring generation of ISOC. Together, these data demonstrate that trafficking via fast recycling endosomes determines TRPC1-STIM1 clustering within ER-PM junctions following ER-Ca2+ store depletion which is critical for the surface expression and function of the channel. Ca2+ influx mediated by TRPC1 modifies Ca2+-dependent physiological response of cells.
ПРОФИЛЬ ДЛЯ ИЗГОТОВЛЕНИЯ ВЕРТИКАЛЬНЫХ ЛОПАСТЕЙ ДЛЯ ВЕРТИКАЛЬНО-ОСЕВЫХ ВЕТРОГЕНЕРАТОРНЫХ УСТАНОВОК

1. Профиль для изготовления вертикальных лопастей вертикально-осевых ветрогенераторных установок, выполненный в виде пластины с загнутыми сторонами, отличающийся тем, что пластина имеет форму прямоугольника, одна из сторон которого загнута на угол 135-170°, а площадь загнутой пластины равна ½ площади второй пластины, образующей указанный угол, при этом противоположная сторона прямоугольника загнута на угол 10-45° в противоположную сторону относительно первой стороны, а площадь загнутой пластины равна площади второй пластины, образующей указанный угол и являющейся общей для обоих вышеуказанных углов.2. Профиль по п.1, отличающийся тем, что с торцов заглушен пластинами.3. Профиль по п.1, отличающийся тем, что между пластинами, образующими вышеуказанные углы, установлены поперечные перегородки.
Harmonization of the hospital systems - a clinical pattern of the cross-border home healthcare provided for the people residing in the Veneto region and in the Obalno-Kraska area in Slovenia

The cross-border cooperation project aims at a deeper knowledge of the mutual administrative and regulatory systems to detect the most suitable joint actions that can promote exchanges of medical and nursing skills, remote healthcare, the direct intervention of medical staff and the patients’ mobility between the two hospitals. The clinical pattern herein proposed is meant to integrate the work of health facilities staff with the hospital departments through the use of new technologies, so that patients can benefit from a direct home assistance. The project involves general practitioners, home health aides, the specialist nurses of local health district and the health staff working in the departments of the hospital control centres. The clinical programme includes chronic patients, who require a continuous around-the-clock monitoring of some vital parameters, or patients who are cared for by healthcare providers at regular intervals. The pattern envisages the recording of the patients’ vital parameters, the telematic data transmission to the data monitoring centres, the physician’s consultation and possibly the transmission of results to the local operators and the general practitioners. To implement this system, some guidelines have been drawn up for the training of the hospital staff. Thanks to the use of the Internet, videoconferences and e-learning, fast and innovative exchanges are possible. The project aims at providing a quality-certified home healthcare, whereby the service is organized in keeping with a common health protocol consisting of several functional areas, that must be interrelated.
3-MCPD in food other than soy sauce or hydrolysed vegetable protein (HVP)

This review gives an overview of current knowledge about 3-monochloropropane-1,2-diol (3-MCPD) formation and detection. Although 3-MCPD is often mentioned with regard to soy sauce and acid-hydrolysed vegetable protein (HVP), and much research has been done in that area, the emphasis here is placed on other foods. This contaminant can be found in a great variety of foodstuffs and is difficult to avoid in our daily nutrition. Despite its low concentration in most foods, its carcinogenic properties are of general concern. Its formation is a multivariate problem influenced by factors such as heat, moisture and sugar/lipid content, depending on the type of food and respective processing employed. Understanding the formation of this contaminant in food is fundamental to not only preventing or reducing it, but also developing efficient analytical methods of detecting it. Considering the differences between 3-MCPD-containing foods, and the need to test for the contaminant at different levels of food processing, one would expect a variety of analytical approaches. In this review, an attempt is made to provide an up-to-date list of available analytical methods and to highlight the differences among these techniques. Finally, the emergence of 3-MCPD esters and analytical techniques for them are also discussed here, although they are not the main focus of this review.
Hacia un Pasaporte de Renovación de Edificios en España: necesidades y oportunidades a la luz de experiencias europeas

La Directiva (UE) 2018/844 (Energy Performance of Building Directive-EPBD) introdujo los Pasaportes de Renovación de Edificios (Building Renovation Passport-BRP) como instrumentos que prometen impulsar la renovación energética a largo plazo en la Unión Europea. En España, empero, la transposición total de esta Directiva no se ha realizado y el estudio de las particularidades del BRP español es expectante. Este artículo pretende aportar elementos que contribuyan al debate de la implementación del BRP español mediante el estudio de iniciativas existentes de BRP europeos, determinando sus carencias y oportunidades, y destacando las diferencias para la futura aplicación del instrumento en España. El análisis sugiere que la implementación del BRP español sería útil solo en condiciones de simetría informativa y con población sensibilizada, siendo imprescindible reforzar la transparencia de los datos y la generación de confianza en la información energética existente. Mención aparte merecen las dificultades derivadas del régimen de multipropiedad residencial dominante.
Gas-phase formation of acetaldehyde: review and new theoretical computations

Among all the interstellar complex organic molecules (iCOMs), acetaldehyde is one of the most widely detected species. The question of its formation route(s) is, therefore, of a major interest regarding astrochemical models. In this paper, we provide an extensive review of the gas-phase formation paths that were, or are, reported in the literature and the major astrochemical databases. Four different gas-phase formation routes stand out : (1) CH$_3$OCH$_3$ + H$^+$ / CH$_3$CHOH$^+$ + e$^-$, (2) C$_2$H$_5$ + O($^3$P), (3) CH$_3$OH + CH and (4) CH$_3$CH$_2$OH + OH / CH$_3$CHOH + O($^3$P). Paths (2) and (3) were not studied neither via laboratory or theoretical works in the low temperature and density regime valid for the ISM. Thus, we carried out new accurate quantum chemistry computations. A theoretical kinetics study at low temperatures (7-300 K), adopting the RRKM scheme, was also performed. We confirm that reaction (2) is efficient in forming acetaldehyde in the 7-300 temperature range (alpha = 1.21 x 10$^{-10}$ cm$^3$ s$^{-1}$ and beta = 0.16). On the contrary, our new computations disprove the formation of acetaldehyde through reaction (3) (alpha = 1.84, 0.67 x 10$^{-13}$ cm$^3$ s$^{-1}$ and beta = -0.07, -0.95). Path (1) was showed to be inefficient too by recent computations, while path (4) was formerly considered for glycolaldehyde formation, having acetaldehyde as a by-product. In conclusions, of the four above paths only two, the (2) and (4), are potentially efficient gas-phase reaction routes for the formation of acetaldehyde and we encourage astrochemical modellers to only consider them. Comparison with astronomical observations suggest that path (4) may actually play the major role.
Market Access, Well-being, and Nutrition: Evidence from Ethiopia

Summary We use a unique data source from a rural area in northwestern Ethiopia to analyze the relationship between household/individual well-being, nutrition, and market access. We find that households residing in relatively more remote areas consume substantially less than households nearer to the market, they are more food insecure, and their school enrollment rates are lower. Although their diets are also less diverse, we find no significant differences in mother and child anthropometric measures. Part of the differences in well-being that we do observe can be attributed to lower household agricultural production in remote areas. Nonetheless agricultural production differences alone do not account for all the differences in household consumption levels for remote households. An additional contributing factor is the terms of trade for remote households that negatively affect both the size of the agricultural surplus that these households market and the quantity of food items that they purchase. Reducing transaction costs for remote households and facilitating migration could help equalize well-being among more or less favored locations.
Catheter-directed Thrombolysis and Stenting in the Treatment of Iliac Vein Compression Syndrome with Acute Iliofemoral Deep Vein Thrombosis: Outcome and Follow-up

The purpose of this study was to evaluate the safety and effectiveness of catheter-directed thrombolysis (CDT) and stenting in the treatment of iliac vein compression syndrome (IVCS) with acute iliofemoral deep vein thrombosis (DVT).A retrospective analysis was conducted in 61 patients (36 women, 25 men, age range 32-90 years, mean 64 years) who had IVCS with acute iliofemoral thrmobosis (≤10 days) and were treated by CDT and stenting between June 2006 and August 2011. All patients presented with IVCS with a median duration of 4.1 days and were treated with CDT (urokinase: initial dose of 125,000-250,000 U followed by 20,000-60,000 U/hr) followed by stent placement. Filters were implanted in those patients with existing pulmonary embolism (PE), inferior caval vein thrombosis, or in accordance with the patients' request. The patency, the pressure gradient crossing the stenosis of the iliac vein, both thigh and calf limb circumferences, and complications were assessed before and after CDT and stenting. A Duplex ultrasound was used to perform follow-up examinations at 1 month, 6 months, 1 year, 2 years, 3 years, 4 years, and 5 years after the operation.Three patients had PE before CDT as assessed by the computed tomography angiography. A total of 28 patients had a filter implanted (25 patients had a Cordis permanent filter and 3 patients had a Braun temporary filter). A total of 68 stents were implanted in 61 patients. Overall, the 1-month, 6-month, 1-year, 2-year, 3-year, and 5-year primary patency rates were 96.7%, 95.1%, 91.8%, 90.2%, 88.5%, and 85.2%, respectively. The pressure gradient crossing the stenosis of the iliac vein decreased significantly after CDT and stenting (7.22 ± 4.64 vs. 1.82 ± 2.78 cm H2O, P < 0.001). The reductions of thigh and calf circumferences were 66.7% (6.19 ± 2.67 vs. 1.98 ± 1.43 cm) and 61.6% (4.36 ± 2.10 vs. 1.46 ± 1.10 cm), respectively. Reocclusion occurred in 7 patients within 1-27 months. Four patients (7%) experienced minor bleeding and were treated successfully with sandbag compression. One patient felt light pain on the left waist after 3 months of stenting. No large hematoma, stent migration, or acute thrombosis complications occurred during the procedure. Two patients died from nonvascular causes during a follow-up of 2-62 months (mean, 31.0 months). Four patients were found with limb swelling and three patients felt heaviness. The incidence rate of postthrombotic syndrome was 11.5% (7/61).Treatment with CDT for IVCS with acute DVT achieves good patency and vein function after 5 years of follow-up in this study. However, further evidence is required to establish longer term benefits.
Community friendly miniliner

UNIFIER19, the Community Friendly Miniliner, is an innovative commuter concept specifically designed to enable a new, environmentally sustainable and cost-efficient air mobility solution. This 19-passenger near-zero-emission aircraft is designed to provide a diffused service connecting smaller airports among them and with hubs, accommodating both scheduled and on-demand shuttle flights. The ability of the UNIFIER19 concept to capture the mobility demand for short- and very short-haul travel rests on a dedicated market study focusing on two scenarios: the “miniliner”, serving a potentially huge small airport network, and the “microfeeder”, providing a rapid transfer to hubs from local airports and even unpaved airfields. 

The capability to achieve substantial emission reduction performance is based on the adoption of modular propulsive solutions including different propellers and different combinations of battery and range-extending technologies. The propulsive architecture is integrated with airframe design, in the quest for maximum aerodynamic advantages, while guaranteeing producibility and maintainability of the design solution.

The result is a family of aircraft sharing a single airframe, accommodating multiple cargo and passenger-seating layouts, as well as multiple motive power-generation solutions. Powertrain modularity eases future upgrades via supplementary type-certificates, granting an extended commercial life.

Aiming to a reduction in CO2, NOx and acoustic emissions by at least 20% compared to the 19 seaters in service today, UNIFIER19 shall offer a new mobility experience for our communities that is as easy to use as a bus. UNIFIER19 shall exploit the sparse, underused European small airport network avoiding overwhelming burdens for new ground infrastructures and providing a commercially viable response to Europe’s need for mobility.
Assistant for quality check during construction execution processes for energy-efficient buildings

Assistant for Quality Check during Construction Execution Processes for Energy-efficienT buildings

Problem: What the consortium sees as a major problem today is the potential loss of benefits of energy-efficient building components because of the lack of knowledge or bad implementation during the construction processes.


Solution: During the project ACCEPT will be created – An assistant for quality check during construction execution processes for energy-efficienT buildings. The assistant will run on Smart Glasses and unobtrusively guide workers during the construction on site. This provides a standardized and coordinated process for all workers, ensuring that all benefits of energy-efficient building components are maintained.

From a user perspective ACCEPT is focused on the following very clear main results:

1. The Construction Operator Assistant App (CoOpApp) running on Smart Glasses, which passively collects data and actively provides guidance to the worker on site during the building process. (Pillar I: Advanced Knowledge Transfer for Energy-efficient Construction)
2. A Site Manager App (SiMaApp)   running on a mobile device, which allows to remotely coordinate the working process as well as collect additional data on site by different sensors. (Pillar II: Agile Project Coordination for Bridging Heterogeneity)

3. An interactive web-based Dashboard as a monitoring and quality assurance solution. The Dashboard will use self-inspection methods to determine important characteristics such as U-Values. (Pillar III: Adaptive Quality Assurance with Self-Inspection Features)

The project is fully build around achieving a maximum of impaxt: The three results will be accompanied by 7 real-world pilots grouped into 3 piloting areas within the project. Pilots are located in 4 different EU countries.
CHOCOLATE PRODUCT

The present invention relates to a food product and to a method for the production thereof.
TARPAULIN USING RESIN COMPOSITION FOR PRESS-COATING AND METHOD FOR PREPARING THE SAME

The present invention relates to a tarpaulin using resin composition for press-coating and a preparation method thereof. The tarpaulin comprises a polypropylene woven fabric layer prepared by weaving polypropylene multifilament yarn; and a resin composition layer which is press-coated on either or both sides of said polypropylene woven fabric layer, wherein the resin composition is obtained by melt-kneading ethylene-propylene copolymer and ethylene-octene random copolymer or styrene-ethylene-butene block copolymer. The tarpaulin of the present invention as obtained by using a resin composition for press-coating is flexible, light and recyclable. Because the tarpaulin of the present invention has an excellent mechanical strength, it is suitable for use as an industrial material.
<strong>Taxonomy of recent Adeonidae (Bryozoa, Cheilostomata) from Brazil, with the description of four new species </strong>

Here we present the taxonomy of the cheilostome genera Adeonellopsis MacGillivray, 1886 and Reptadeonella Busk, 1884 in Brazil. Of the six species previously reported in Brazilian waters, we include redescriptions of Adeonellopsis subsulcata (Smitt, 1873), Reptadeonella bipartita (Canu & Bassler, 1928) and Reptadeonella costulata (Canu & Bassler, 1928). Four new species of Reptadeonella are described: Reptadeonella aspera n. sp., Reptadeonella brasiliensis n. sp. (previously misidentified as Reptadeonella violacea), Reptadeonella cucullata n. sp. and Reptadeonella leilae n. sp. Reptadeonella aspera n. sp., from Bahia State, is characterized by rugose frontal calcification, a tubular peristome, small suboral avicularium and elliptical spiramen. Reptadeonella brasiliensis n. sp. is the commonest intertidal species in NE Brazil; it is distinguished from other Brazilian Reptadeonella in having a nodular peristome, large subperistomial areolar pore and zooids with one or two frontal pores frequently replaced by a suboral avicularium and crescentic spiramen. Reptadeonella cucullata n. sp., from Espírito Santo and Bahia states, has a hood-like peristome, large subperistomial areolar pore, suboral avicularium with curved mandible and denticulate spiramen. Reptadeonella leilae n. sp., described from Bahia State, has a frontal shield with small granules, tubular peristome, semilunar to semicircular subperistomial areolar pore and circular spiramen. Diagnostic characters of Reptadeonella species are discussed.
Spinning speed measurement - in false twister using resonance circuit to give output suitable for digital frequency meter

As the rotary tube section of a mon- or bi-galette false twisting machine spins, a scatter field is developed which is detected by a coil and a current induced. An amplifier with a resistance and condenser at its input form a resonance circuit with a basic frequency matching the basic frequency of the scatter oscillation, allowing a digital frequency meter to record the speed up to 750,000 rpm.
An endogenous tumour-promoting ligand of the human aryl hydrocarbon receptor

Activation of the aryl hydrocarbon receptor (AHR) by environmental xenobiotic toxic chemicals, for instance 2,3,7,8-tetrachlorodibenzo-p-dioxin (dioxin), has been implicated in a variety of cellular processes such as embryogenesis, transformation, tumorigenesis and inflammation. But the identity of an endogenous ligand activating the AHR under physiological conditions in the absence of environmental toxic chemicals is still unknown. Here we identify the tryptophan (Trp) catabolite kynurenine (Kyn) as an endogenous ligand of the human AHR that is constitutively generated by human tumour cells via tryptophan-2,3-dioxygenase (TDO), a liver- and neuron-derived Trp-degrading enzyme not yet implicated in cancer biology. TDO-derived Kyn suppresses antitumour immune responses and promotes tumour-cell survival and motility through the AHR in an autocrine/paracrine fashion. The TDO-AHR pathway is active in human brain tumours and is associated with malignant progression and poor survival. Because Kyn is produced during cancer progression and inflammation in the local microenvironment in amounts sufficient for activating the human AHR, these results provide evidence for a previously unidentified pathophysiological function of the AHR with profound implications for cancer and immune biology.
Conformational Transitions that Enable Histidine Kinase Autophosphorylation and Receptor Array Integration

During bacterial chemotaxis, transmembrane chemoreceptor arrays regulate autophosphorylation of the dimeric histidine kinase CheA. The five domains of CheA (P1-P5) each play a specific role in coupling receptor stimulation to CheA activity. Biochemical and X-ray scattering studies of thermostable CheA from Thermotoga maritima determine that the His-containing substrate domain (P1) is sequestered by interactions that depend upon P1 of the adjacent subunit. Non-hydrolyzable ATP analogs (but not ATP or ADP) release P1 from the protein core (domains P3P4P5) and increase its mobility. Detachment of both P1 domains or removal of one within a dimer increases net autophosphorylation substantially at physiological temperature (55°C). However, nearly all activity is lost without the dimerization domain (P3). The linker length between P1 and P3 dictates intersubunit (trans) versus intrasubunit (cis) autophosphorylation, with the trans reaction requiring a minimum length of 47 residues. A new crystal structure of the most active dimerization-plus-kinase unit (P3P4) reveals trans directing interactions between the tether connecting P3 to P2-P1 and the adjacent ATP-binding (P4) domain. The orientation of P4 relative to P3 in the P3P4 structure supports a planar CheA conformation that is required by membrane array models, and it suggests that the ATP lid of CheA may be poised to interact with receptors and coupling proteins. Collectively, these data suggest that the P1 domains are restrained in the off-state as a result of cross-subunit interactions. Perturbations at the nucleotide-binding pocket increase P1 mobility and access of the substrate His to P4-bound ATP.
METHODS FOR INCREASING TOTAL OIL LEVELS IN PLANTS

The present invention is in the field of plant genetics and biochemistry. More specifically, the present invention relates to genes affecting the level and composition of oil in plants. In particular, the present invention is directed to methods for increasing the oil level in plants and seeds. Moreover, the present invention includes and provides methods for producing plants and obtaining seeds with altered fatty acid composition.