SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Bacteriocins and human commensal bacteria as a new strategy to inhibit the opportunistic human pathogen streptococcus pneumoniae

When the Noble Prize-winning Alexandre Fleming discovered antibiotics, he already noticed that microorganisms developed resistance mechanisms to survive. Therefore, he anticipated that a misuse of antimicrobial compounds to treat infections will drive the selection of hyper-resistant strains and the resurgence of almost-eradicated infectious diseases. Nowadays, the problem is so critical that the World Health Organization foresees that superbugs will outcompete cancer and cardiovascular diseases to become the first cause of mortality on the planet in less than 30 years (horizon 2050). Recently, the international organization drew a list of 10 priority pathogens that includes Streptococcus pneumoniae, a bacterium notorious in pneumonia (major upper respiratory tract infections), endocarditis, meningitis and brain abscess. To replace or restore antibiotic action, we thus need to find alternative strategies. In this proposal, I aim to use bacteriocins, small antimicrobial peptides secreted by bacteria, to kill S. pneumoniae. They are currently underexploited for human need but feature many valuable characteristics (e.g., efficiency, evolvability, specific spectrum, cheap/easy production, high sequence diversity, stability) complementary to antibiotics. I will test a collection of hundreds of bacteriocins and, according to their mode of action, will rationally assemble “overwhelming” bacteriocin cocktails to prevent emergence of resistance. In parallel, a tantalizing idea would be to exploit the beneficial bacteria of our microbiota and mobilize their bacteriocins to treat local infections. So, I will perform ex vivo infection of human epithelia with S. pneumoniae and test how bacteriocin-induced S. salivarius, a commensal bacterium of our gut, influences it. Besides generating valuable fundamental insight into the S. pneumoniae resistance mechanisms and infection cycle, the results of this project will also pave the way to fight against other notorious pathogens.
Cryogenic air separation process and apparatus.

An energy efficient process and apparatus for the cryogenic separation of air by rectification to produce at least one vapor fraction, at least one liquid fraction, and at least one nitrogen product stream wherein cooled and pressurized feed air in vapor form is condensed by indirect heat exchange contact with at least one liquid fraction to vaporize the liquid fraction and condense the feed air stream, then vaporizing the condensed feed air stream by indirect heat exchange contact with at least one vapor fraction thereby condensing the vapor fraction, and then using the vaporized feed air stream as feed air for cryogenic separation by rectification.
300Mm pilot line for smart power and power discretes

R3-POWERUP will push through the new generation of 300mm Pilot Line Facility for Smart Power technology in Europe. This will enable the European industry to set the world reference of innovative and competitive solutions for critical societal challenges, like Energy saving and CO2 Reduction (ref. to COP21 Agreement ), as well as Sustainable Environment through electric mobility and industrial power efficiency.

● Development  and demonstration of a brand new 300mm  advanced manufacturing facility addressing a multi-KET Pilot Line (i.e. Nanoelectronics, Nanotechnology, Advanced Manufacturing)
● Improvement in productivity and competitiveness of integrated IC solutions for smart power and power discrete technologies.

The strategy of the project is the following:
● The Pilot Line will enable the realization of sub-100nm Smart Power processes, starting from the 90nm BCD10 process, taking profit from the advanced and peculiar equipments available only for 300mm wafer size.
● The availability of a 300mm full processing line will also exploit the portability to 300mm of the most critical and expensive process steps devoted to power discrete devices.
● The Pilot Line will build on Digital Factory and Industry 4.0 principles, enforcing a flexible, adaptive and reliable facility, in order to investigate also the synergy and economic feasibility of supporting both Smart Power and power discrete processes in the same manufacturing line.
● The application of such technologies will be a breakthrough enabler for Energy Efficiency and CO2 Reduction worldwide, in line with COP21’s global action plan. 

The Pilot Line is based on three main pillars:
1. Market driven continuous innovation on smart-power and power discrete;
2. Industrial policy focused on high quality and mass production’s cost optimization; 
3. Set the ground for future wafer upgrade of “More than Moore” disruptive technologies (e.g. advanced MEMS manufacturing,  now at 200mm)
Sharing gains from trade: global markets and farmers welfare in developing countries

The majority of the global poor live in rural areas and earn their livelihoods in agriculture. Linking farmers in developing countries (LDCs) to global markets, therefore, could potentially spur growth and reduce poverty. Market imperfections in agricultural chains in producing countries, however, limit these gains. Which policy tools, if any, help farmers in LDCs realize and share the gains from trade? I propose three broad projects that develop the tools to answer this question. 
The first project designs and implements the first randomized control trial (RCT) to test for the causes and consequences of market failures interacting along multiple layers of agricultural value chains. This is a necessary step to design targeted policy responses.
The second project develops and estimates the first structural model of an agricultural value chain to evaluate different regulatory interventions. Historically, as well as today, governments have intervened in agricultural chains through a diverse array of policies and regulations. RCTs are not sufficient to evaluate these policies. The project develops flexible tools to perform counterfactual analysis and evaluate the merits of alternative policies and regulations in a variety of contexts. 
The third project studies voluntary sustainability standards (VSSs) (e.g., Fair Trade, Rainforest Alliance). VSSs are increasingly popular responses to market failures in agricultural chains in LDCs. Unlike regulatory interventions, VSSs directly affect only market participants that take them up. The project combines quasi-experimental and structural techniques to evaluate the direct impact, the indirect spillover effects, and the broader distributional consequences of VSSs. 
The three projects form a coherent research agenda that develops a comprehensive set of tools to evaluate existing agricultural policies and design better ones so that small producers in developing countries can realize and share the gains from globalization.
A touchless microcomponent gripper for precision handling and microassembly

Touchless Automation is a contactless solution to handle microcomponents of any shape & material. 
It addresses the acute problem of microcomponents frequently getting damaged, contaminated, and as a result, discarded during the precision assembly processes. Our novel microgripper combines ultrasound & vacuum to make the microcomponents levitate underneath it at the distance of <50 µm. It is the smallest solution of this kind on the market.
We are targeting semiconductor manufacturing equipment & watchmaking industries for commercialization of Touchless Automation (with total addressable markets of €91.8m+ & €33.6m+ respectively). In 2017 we have generated strong market interest from other markets as well—pharmaceuticals, optoelectronics, metrology & others. 
In semiconductor equipment manufacturers & watchmakers, we have already defined technological feasibility studies with our prospects (Rolex, Ciposa, Comadur) to validate characteristics of the microgripper. In the implemented studies we have seen a 18-24% reduction in microparts damage & contamination. Finally, our partner Sabato Microtec—one of the leading global high-precision micromechanics manufacturers—will back us up with expertise, a wide network of contacts & equipment to develop & scale.
In Oct 2017 we have received a PCT report that confirmed innovation over prior art, which removed the final obstacle (from a competitive patent) and gave us freedom to operate and to commercialize Touchless Automation.
With Touchless Automation we are conservatively estimating €15m+ revenues by 2021 & €26m+ by 2023. In this Phase 1 project we will produce detailed market analysis for key & adjacent market segments, validate price ranges, determine sources of additional revenue streams & define a strong IP protection strategy.
The HST/ACS Coma Cluster Survey – X. Nuclear star clusters in low-mass early-type galaxies: scaling relations

We present scaling relations between structural properties of nuclear star clusters and their host galaxies for a sample of early-type dwarf galaxies observed as part of the Hubble Space Telescope (HST) Advanced Camera for Surveys (ACS) Coma Cluster Survey. We have analysed the light profiles of 200 early-type dwarf galaxies in the magnitude range $16.0 < m_{F814W} < 22.6 $ mag, corresponding to $-19.0 < M_{F814W} < -12.4 $ mag. Nuclear star clusters are detected in 80% of the galaxies, thus doubling the sample of HST-observed early-type dwarf galaxies with nuclear star clusters. \changed{We confirm that the} nuclear star cluster detection fraction decreases strongly toward faint magnitudes. The luminosities of nuclear star clusters do not scale linearly with host galaxy luminosity. A linear fit yields L$_{nuc} \sim $L$_{gal}^{0.57\pm0.05}$. The nuclear star cluster-host galaxy luminosity scaling relation for low-mass early-type dwarf galaxies is consistent with formation by globular cluster accretion. We find that at similar luminosities, galaxies with higher S\'ersic indices have slightly more luminous nuclear star clusters. Rounder galaxies have on average more luminous clusters. Some of the nuclear star clusters are resolved, despite the distance of Coma. We argue that the relation between nuclear star cluster mass and size is consistent with both formation by globular cluster accretion and in situ formation. Our data are consistent with GC inspiraling being the dominant mechanism at low masses, although the observed trend with S\'ersic index suggests that in situ star formation is an important second order effect.
Flexible nanowire devices for energy harvesting

The goal of NanoHarvest is to explore novel solutions for flexible photovoltaic and piezoelectric converters enabled by semiconductor nanowires. The first objective is to demonstrate an innovative concept of flexible solar cells based on free-standing polymer-embedded nanowires which can be applied to almost any supporting material such as plastic, metal foil or even fabrics. The second objective it to develop high-efficiency flexible and compact piezo-generators based on ordered arrays of nanowire heterostructures. The crucial ingredient - and also the common basis - of the two proposed research axes are the advanced nanowire heterostructures: we will develop nanowires with new control-by-design functionalities by engineering their structure at the nanoscale. The main focus of NanoHarvest will be on the III-nitride semiconductors, which are characterized by a strong piezoelectric response and have also demonstrated their ability for efficient photon harvesting in the blue and green parts of the solar spectrum. Our strategy is to address the physical mechanisms governing the energy conversion from the single nanowire level up to the macroscopic device level. The deep understanding gained at the nanoscale will guide the optimization of the device architecture, of the material growth and of the fabrication process. We will make use of Molecular Beam Epitaxy to achieve ultimate control over the nanowire morphology and composition and to produce control-by-design model systems for fundamental studies and for exploration of device physics. The original transfer procedure of the ordered nanowire arrays onto flexible substrates will enable lightweight flexible devices with ultimate performance, which will serve as energy harvesters for nomad applications.
METHOD AND FORMULATION FOR PREPARING LIGNIN FIBRES

The invention relates to a formulation for melt-preparation of lignin-based fibres, which are precursors of carbon fibres. Said formulation comprises lignin, a plasticiser and a cross-linking agent capable of cross-linking with the lignin at a temperature at least 10° C higher than the glass-transition temperature of the intimate blend of the lignin and the plasticiser. A method for preparing lignin-based fibres using this formulation comprises the hot extrusion spinning of an intimate blend of the components of the formulation, under adequate conditions for cross-linking the cross-linking agent and the lignin in the terminal area of the extrusion device used.
Promoting sustainable inner urban development

Due to the political, social and economic structural changes of the 90s in various European cities many former industrial or commercially-used areas were abandoned. The negative impact of these areas on the quality of urban life reaches far beyond the site itself. The conversion process of former commercially-used brownfields located in inner-city districts shows that projects of investors are often at odds with the ideas of municipal authorities on sustainable inner urban development. These conflicting interests create a deadlock caused by the existing administrative tools. PROSIDE improves urban development and ensures that natural areas are preserved and run-down areas restored. Quality of life and environmental quality in inner cities will be clearly enhanced by private investors. The project's communication tools are a contribution to the CADSES information society, providing a database for private investors and promoting communication among all municipal departments as well as a better involvement of European society and the relevant socio-economic units early in the development process. The planning tools bring together the objectives of implementing a more balanced social and economic development of inner urban areas, and reducing environmental damage. Furthermore the PROSIDE approach reduces the time frame for future investor-driven planning activities and increases the success rate of privately funded rehabilitation projects. The co-operation of different cities with various spatial conditions in the CADSES area improves the horizontal exchange of experiences in spatial and environmental planning. The co-operation of university institutions with public administration bodies and private companies enhances the direct information flow and know-how transfer between basic research and practical applications.
CARPET PRODUCT AND PROCESS FOR THE MANUFACTURING OF A CARPET PRODUCT

A carpet product includes in sequence a) a primary backing material having a back side and a face side, with carpet fibers extending from the face side to form a carpet pile and also passing through the primary backing material and forming loops on the back side; b) a primary coating layer on the loops, including a vinyl acetate ethylene copolymer and present at from 542 to 1085 g/m2 (16 to 32 oz./yd2) on a dry solids basis; c) a secondary coating layer on the primary coating layer, including a styrene-butadiene copolymer; and d) a secondary backing material on the secondary coating layer and adhered thereby to the primary coating layer.
Pelvic Exenteration for Recurrent Endometrial Adenocarcinoma: A Retrospective Multi-institutional Study About 21 Patients

Objective The aim of our study was to evaluate morbidity, mortality, and long-term survival of patients who underwent pelvic exenteration (PE) with curative intent for recurrence of endometrial adenocarcinoma during a single decade. Methods We defined a cohort of 21 patients who met our inclusion criteria, referred to 4 cooperating gynecologic oncology settings in Germany and Italy between 2000 and 2011. Data regarding surgery, histology, and oncologic outcomes were collected and statistically evaluated. Survival was determined from the day of exenteration until the last follow-up or death. Results The median age was 66 years. A total of 42.9% of the patients had major complications, and a complete resection was achieved in 85.7% of the patients. A total of 71.4% of the patients had negative nodes. No patient died intraoperatively. The perioperative mortality, calculated within 30 days from PE, was 4.8%. The overall 5-year survival rate, evaluated using the Kaplan-Meier method, was 40%. For the subgroup with complete resection and negative lymph nodes, overall survival reached 60%. Conclusions Despite a high complication rate, PE for solitary pelvic recurrence of endometrial cancer yields a high rate of long-term survival.
SIMPLIFIED METHOD FOR DIGESTION OF CELLULOSIC BIOMASS

The inventive process converts cellulosic biomass into a gel-like state that is readily hydrolyzed by appropriate enzymes. First the biomass is mechanically reduced in size. The biomass is then mixed and kneaded with an aqueous solution of a hydrophilic polymer that acts as a conditioning agent or as a co-solvent. During mixing the cellulose (and hemicellulose) in the biomass swells and becomes hydrated forming a viscous gel-like material. The processed material can then be thinned through the addition of water whereupon hydrolytic enzymes are mixed into the material and rapid hydrolysis into free sugars takes place. Dextrins are effective hydrophilic polymers for conditioning biomass. Polyvinyl alcohol is a particularly effective conditioning agent for use with biomass when converted into a viscous gel by adding borate ions.
Sustainability assessment methods and tools to support decision-making in the process industries

Sustainability assessment methods are needed to support sustainable technology development and to evaluate the impacts of existing solutions, products and technologies. While there are aspects and indicators that are common to all process industries, sector specific tools are required to address the sector specific features in a fair and transparent way. 
At the moment, several tools, assessment methods and indicators exist, but they differ in their goal and scope and are intended for different kind of use within companies, by consumers or by authorities to support policy planning and evaluation. Additionally, different tools are focused for different levels of assessment: product, company, industry or society. Thus the problem is not so much the existence of proper tools but rather the lack of understanding and knowledge on how they should be applied and in which context. Furthermore, suitable tools for analysing resource and energy efficiency within the process industries and across the different sectors should be recognized.
The aim of the SAMT project is to review and make recommendations about the most potential sustainability assessment methods for evaluating energy and resource efficiency in the process industry. 
The analysis will focus on the applicability of different methods in industrial settings, the ability of the methods to support decision-making towards sustainable solutions and the suitability of the tools for cross-sectoral analysis. 
SAMT will evaluate tools that cover either environmental, economic and social aspects, or a combination of these, and apply principles of life cycle thinking. The project will consider demands and make recommendations related to sectorial and cross-sectorial assessment in a wide spectrum of process industries: cement, metal, oil, water, waste and chemical industry. To maximize the impact of the project the work will be supported by active dissemination activities including an implementation strategy as an outcome.
Decision Making by p53: Life versus Death.

Cellular response to DNA damage is multifacted in nature and involves a complex signaling network in which p53 functions as a "molecular node" for converging signals. p53 has been implicated in a variety of cellular processes primarily functioning as a transcription factor and also in a transcription-independent manner. It is rapidly activated following DNA damage with phosphorylation as one of the initial signals. Cellular context as well as the type and severity of DNA damage determine p53 activation code, and its activities are regulated predominantly through protein degradation, post-translational modification and interactions with various cellular co-factors. These events are crucial in decision making by p53 as it has the ability to receive, assess and integrate different signals and route them accordingly to induce cell death or promote cell survival. In this decision making process, its transcriptional role to activate a specific subset of target genes linked to inducing cell cycle arrest or apoptosis is critical that is further fine-tuned by its transcription-independent function. This article reviews the current state of knowledge about the role of p53 in determining the fate of cells that have incurred DNA damage.
Heritage language acquisition: the qualitative nature of input and cross-linguistic influence

This project aims to fill important gaps in our existing knowledge of Heritage Language (HL) acquisition, a subfield of bilingualism studies. While most previous research has focused on describing how HLs diverge from their monolingual baselines, the main objective of HeLA is to understand why heritage grammars develop the way they do. To this end, we focus on the severely understudied population of pre-teenage heritage speakers (HSs) of Spanish. While much attention has been paid to the role of input quantity in HL acquisition, relatively little is known about the qualitative nature of that input. This project investigates input quality by focusing on cross-generational attrition: the situation where HSs’ parents might exhibit changes in their L1 use –due to prolonged exposure to a second language and lack of activation in their first language– which get passed on to the next generation of HSs. We will approach this topic in a unique and novel way, namely by including individual analyses of children and their respective parents, and establishing a one-to-one connection between the two. Thus far, the majority of research on heritage Spanish, has been carried out in the context of the US. HeLA offers a valuable contribution to the field by comparing Spanish in two different linguistic contexts in Europe: the UK and The Netherlands. By looking at phenomena that are instantiated differently in English and Dutch –grammatical gender and subject expression– we will gain more insight into the role of cross-linguistic influence from the majority language. We furthermore combine behavioural and online measures of competence to examine whether the type of task brings anything to bear on the participants’ performances. Gaining a deep understanding of the factors that shape heritage grammars is of considerable importance for the maintenance of immigrant languages and cultures, as well as for stakeholders in the public and private sector charged with supporting such efforts.
Pattern formation in oscillatory media without lateral inhibition

Spontaneous symmetry breaking instabilities are the most common mechanism for how biological, chemical, and physical systems produce spatial patterns. Beginning with Turing's original paper, so-called lateral inhibition-in which negative feedback has greater spread than positive feedback-has been the underlying mechanism for pattern formation in biological models. Despite this, there are many biological systems that exhibit pattern formation but do not have lateral inhibition. In this paper, we present an example of such a system that is able to generate robust patterns emerging from a spatially homogeneous state. In fact, patterns can arise when there is only spatial spread of the activator. Unlike classic Turing pattern formation, these patterns arise from a spatially homogeneous oscillation rather than from a constant steady state.