SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
The Use of Cortical Heterologous Sheets for Sinus Lift Bone Grafting: A Modification of Tulasne's Technique with 7-Year Follow-up

In this article, the authors describe their experience with using cortical deantigenated equine bone sheets in sinus lift grafting procedures performed on 23 patients. The technique employed resembles that described by Tulasne but avoids the need for using harvested calvaria bone and introduces some additional operating variants. The use of heterologous cortical bone sheets effectively managed even large lacerations of the Schneiderian membrane and allowed for immediate stabilization of the heterologous bone granules. Average histomorphometric values for bone cores collected six months after grafting, at the time of implant placement, were: newly formed bone tissue 43.9±4.2%, residual bone substitute 7.4±1.4%, medullary spaces 48.7±4.0%. At seven year follow-up, clinical and radiographic examination indicated that the use of the bone sheets preserved the regenerated bone volume. In conclusion, the use of heterologous cortical bone sheets in association with granular bone graft material enabled long-term stabilization of the graft material and effective management of intra-surgical complications.
Global governance and the european union: future trends and scenarios

GLOBE will approach the issues identified in the call focusing on global problems, which has been defined as strategic priorities in the 2016 EU Global Strategy: trade and development, security and the politics of climate change. We will include also the challenges of migration and global finance as additional areas, which go even beyond the call. The strength of our consortium lies in first-class academic expertise, as composed by top-level European and international scholars, which guarantees not only high-level analysis of the past and present problems of global governance but also contributes to determining solid forward-looking trends and scenarios. We will include participants from all over the EU as well as Argentina, Indonesia, and China.    Regarding each of the global problems selected, we will identify the major roadblocks for effective and coherent global governance, by multiple stakeholders, and in a multi-polar world. GLOBE will be based on 11 workpackages, which will be divided into two clusters. While the first cluster will focus on these problems one by one, the second cluster will move to a more general and prospective level and will elaborate more on risks and drivers for the transformation of current global regimes in the domains examined. While the first cluster will provide policy-makers, academics and the general public with an analytical grip on the state of play in global governance, supported by new theoretical and methodological approaches, the second cluster will equip national and European policy-makers with tools to identify constraints and possibilities in several global governance scenarios in the years 2030 and 2050. Taking into account these alternative scenarios, we will recommend strategies on how the EU might promote enhanced global governance and deal with their future challenges and gridlocks.
ENHANCEMENT OF INDUSTRIAL PRODUCTION BY INCREASING SUBSTRATE TRANSPORT

A method for enhancing a host cell's biosynthetic production of a desired compound derived from an at least partially intracellular pathway of said host cell is described. Such method comprises selecting a host cell that has an at least partially intracellular synthetic pathway which utilizes an extracellular substrate; increasing the transport of said extracellular substrate into said host cell while maintaining the integrity of the host cell, culturing the host cell to produce said extracellular substrate; and producing the desired compound. The transport of the substrate is increased by transforming into the host cell DNA encoding for one or more enzymes transporting the substrate into the host cell.
Association of uranium with organic matter- and iron-bearing colloids in wetland environments

In the context of decreasing water standards for uranium (U) concentrations in drinking water, the use of natural or constructed wetlands is often proposed for cost-effective small-scale water treatment. The underlying mechanism is immobilization of the dissolved form of uranium, U(VI), through its reduction to a less mobile form, U(IV). However, the long-term stability of U(IV) species formed is not well understood. Indeed, a significant amount of U is found labile, even in its reduced form, and contaminates the hydrologic network in several sites. Previous studies suggest that the colloidal phase is responsible for the dispersion of U(IV) in the watershed. In addition, it has been hypothesized that the propensity of the colloidal phase to bind and mobilize U(IV) depends on the association of Fe with colloidal natural organic matter (NOM), and on the colloids conformation. However, these hypotheses need to be investigated and information is lacking on the processes leading to the formation of the pressented vector of U(IV) dissemination, i.e. Fe-NOM colloids. Understanding these processes is crucial for predicting the efficiency of wetlands as traps of U water contamination. We propose to (i) further characterize wetland colloids, in a broader panel of wetlands, and use correlation analysis to pinpoint factors controlling the NOM shape and its ability for Fe- and U-binding; (ii) test in batch experiments the effect of Fe sources on NOM properties in solution; and (iii) test the reactivity of Fe-NOM colloids with U(IV) and identify the U(IV) binding mechanisms at molecular levels. The original approach proposed will help decision making for uses of wetland filters, and also generate fundamental knowledge about NOM reactivity. The project involves the state-of-the-art expertise of the host institute (EPFL) about U geochemistry in wetlands, and the complementary expertise of Geneva University about characterization of colloidal organic matter.
Rapid mass loss of debris covered glaciers in high mountain asia

The research proposed uses an integrated data-modelling approach to elucidate the role that debris-covered glaciers play in the water cycle of High Mountain Asia (HMA) and establish how future HMA glacier and runoff will evolve. Debris-covered glaciers are of great significance for the hydrology of HMA, with large contributions to headwater streamflow. Despite this, their mass balance, hydrological role and future changes are poorly constrained, challenging model predictions of future water resources. Debris mantles insulate the ice and reduce ablation, but large-scale research indicates that HMA debris-covered glaciers are losing mass at rates similar to debris-free glaciers. This anomalous behaviour has profound implications for future glacier mass balance and runoff, but has not been reproduced with models, a fundamental limitation to a global assessment. I aim to establish that: 1) supraglacial cliffs and ponds are responsible for higher than expected mass losses of HMA debris-covered glaciers, because they act as windows of energy transfer through the debris; and that 2) their inclusion into models of glacier evolution will provide essential new estimates of glacier changes and future water availability in HMA. RAVEN will achieve these aims through combination of high-resolution satellite observations, field data and physically-based models in four sites along the Himalayan arc. This unprecedented setup captures the variety of climate and glaciers across HMA. Using satellite images I will investigate the spatial distribution and temporal evolution of cliffs and ponds; the insights will be used to develop physically-based models of cliff and pond ablation, which will be included in a glacio-hydrological model. Future glacier and runoff response will be projected using downscaled climate scenarios, allowing new estimates of glacier changes and future runoff for a data-starved region where millions of people depend on the water resources from glaciers and snow.
Development of cdc production technologies for the next generation of supercapacitors, feasibility study

Skeleton Technologies is a developer and manufacturer of high performance ultracapacitors, devices which store and deliver energy much more rapidly than conventional batteries. Their specialist technology, based on in-house-manufactured carbide derived carbon (CDC) electrodes, produces 2.5 times the power to weight ratio, subsequently a 40% reduction in costs, compared to the state of the art.

The company aims to build on successful sales to niche space and motorsport markets, by up-scaling CDC production, reducing costs, allowing for more ubiquitous adoption of their products for energy-saving applications in price-sensitive markets. Initially, Skeleton will fulfil explicit demand in the automotive industry for high current, high power/weight ultracapacitors, facilitating advances in stop-start, regenerative braking and cold starting technologies. Applications have also been identified in smart grids, supporting renewable energy sources and circumventing power outages.

Skeleton also plans to market its specially treated CDC materials to manufacturers of ultracapacitors and Li-ion capacitors, and to investigate further identified uses, such as in advanced batteries, gas adsorption, water desalination and as a catalyst in fuel cells.

The Phase I feasibility study will comprise two consecutive parts: 1) completion of the planning for the up-scaled CDC production facility (to be implemented in the 24 month Phase II project), and 2) conduction of collaborative consultation with other ultracapacitor manufacturers, who will be early adopters of the CDC.

The project will address the European and global challenge of developing low carbon and efficient energy systems. CDC based ultracapacitors will facilitate advanced energy efficiency and energy recapturing systems, and will support renewable energy production and smart grids. Fulfilment of high demand in a global market projected to see 30% annual growth, will also represent significant economic benefits for member sta
Iron as a driver of fibrosis and regeneration

I have worked over the last five years on understanding how ion channels control inflammation, immunity, metabolism and cancer, with a strong emphasis on Ca2+ signaling. Now, I would like to take advantage of my diverse background in cation signaling and inflammation and integrate it with the outstanding expertise of Manuel Serrano´s lab in regeneration and aging, to ask fundamental questions on the role of iron in regulation of plasticity and fibrosis. Clinical reports have described local deposition of iron around fibrotic tissues, although the significance of this remains poorly understood and unexplored. My unifying hypothesis is that fibrosis is the manifestations of ongoing free-iron release into injured organs and tissues, which without clearance maintains chronic inflammation and prevents regeneration. The project is divided as follows:  Objective #1 – Iron induced inflammation: the impact of free-iron on inflammatory cytokine and chemokine expression and signaling pathways. I have preliminary data indicating that free-iron is a potent inducer of inflammatory cytokines in fibroblasts.  Objective #2 – Free-iron as a causative of fibrosis: effect of iron on cellular senescence and on mouse models of fibrosis; and iron homeostasis in human patients with fibrosis. In vitro, I have found that free-iron is an inducer of senescence. Furthermore, in a pilot study, I have found that bleomycin-induced lung fibrosis in mice is accompanied by high levels of iron deposition. Objective #3: Iron clearance and regeneration: Effects of free-iron and iron induced cytokines on acquired plasticity in vitro and on wound healing. Surprisingly, my preliminary data indicate that chelation of free-iron completely blocks acquisition of pluripotency, but has no effect on expansion of stem cells.  I anticipate that the completion of this action will yield new fundamental insights into the underlying mechanisms of fibrosis and regeneration, and will allow me the transit to independence.
Regulation of Ecological Stability in the Conditions of a Civil Society

In the article questions of regulation of ecological stability in the conditions of the further deepening of democratic reforms and formation of a civil society as one of major factors of maintenance of a sustainable development of the country are considered. Authors of the article explore the effects of the reforms in the field of ecology, environmental stability participation process government agencies. In the article summarizes the results of the international cooperation Uzbekistan in ecology. Interesting posts is about the flora and fauna of the country. The authors studied the relationship with the ecological stability of educating young people. Authors of the scientific article noted that the regulation of environmental sustainability comes to the fore in connection with the implementation of reforms in education and in other industries and education program harmoniously developed personality. It should be noted that in the context of civil society to ensure environmental sustainability is becoming an important component of regional security, exerting an increasing influence on well-being and health, as well as on the economic impact of all sectors of industry and agriculture. In these circumstances, the strategic objectives of environmental sustainability placed the radical improvement of the environment, rehabilitation and prevention of degradation of natural systems, protect human health and the creation of conditions for improving the quality and life expectancy of the population.
Integrating multi-scale knowledge on cardiac development into a computational model of ventricular trabeculation

Insights into the mechanisms of development of the mammalian four-chambered heart are based on biological observations at organ, tissue, cell, and molecular levels, but the full integration of these experimental data awaits a systems biology approach. Such an approach can be employed to formulate and test conceptual models in a computational simulation. To illustrate how this can be applied to heart development, we used the process of trabeculation, which is the formation of muscular strands during chamber development. We selected this process because it is localized, involves a restricted number of cell types, and a range of experimental data is available. Trabeculation of the ventricles is based on the interplay between endocardial and myocardial cells and involves molecular pathways underlying cell-cell interactions and tissue-specific cell behavior. A cellular Potts model was used for the simulation of these multi-scale processes. With fairly simple inputs, of which the relative contributions are unknown, an iterative exploration achieved an outcome that resembles the trabeculation process and allows further investigation of contributing factors. The systems biology pipeline from biological observations and conceptual modeling to a mathematical model and computational algorithms is described and discussed. The multi-level biological observations provide the components and their connections of the conceptual model. However, the true strength of systems biology must be found in the biological test of the predictions that result from an experimental change in the computational model. These validated predictions will ultimately elucidate the functional role of a component or interaction in the process of heart development.
Abundance of zooplankton and physico-chemical parameters of a polyculture fish pond of Manikganj, Bangladesh

Composition and abundance of zooplankton in a polyculture pond was studied during June 2003 to May 2004. A total of 33 major species of zooplankton including 11genera of Rotifera, 4 of Copepoda, 4 genera of Cladocera and 2 genera of Protozoa were identified. The monthly abundance of zooplankton varied form 4228 indiv/l in October 2003 to169 indiv/l in January 2004. Among the total zooplankton, Rotifera comprised of 71.07%, Copepoda comprised of 12.49% Nauplii comprised of 11.96%, Cladocera comprised of 1.49% and Protozoa comprised of 2.99%. Water temperature (r = 0.18), free CO2 (r = 0.40), TDS (r = 0.14) and water depth (r = 0.55) showed positive correlation with zooplankton but air temperature, pH, dissolved O2, total hardness and ammonia showed negative correlation (the coefficients being -0.18, -0.05, -0.25, -0.38 and -0.11 respectively) with the occurrence of zooplankton. The average growth of fishes and zooplankton showed positive correlation in all cases but the relations were insignificant when tested statistically.Bangladesh J. Zool. 42(1): 67-76, 2014
Antioxidative Potency and UV–Vis spectra features of the compounds resulting from the chelation of Fe2+ by Caffeic Acid Phenethyl Ester and two of its derivatives

Abstract Chelation of the solvated iron (II) cation (Fe(H2O)62+ and Fe(CH3OH)62+) by Caffeic Acid Phenethyl Ester (CAPE), 3-Methyl-2-Butenyl Caffeate (MBC) and Benzoic Caffeate (BC) has been investigated through the ONIOM(B3LYP/6-31G(d,p):UFF) calculation and 6-31+G(d) set for Fe2+. The chelates (Fe(CAPE)2+, Fe(MBC)2+ and Fe(BC)2+) were treated by the density functional theory (DFT) calculation and the four ligands (H2O or CH3OH) around the iron were treated by UFF calculation. Time dependent (TD-DFT) calculations were used to reproduce the electronic UV–Vis spectra of chelates. In the thermodynamic point of view, the results indicated that the chelation of Fe2+ by the three molecules was spontaneous and that MBC got the best capacity to chelate Fe2+. The complexes are more antioxidant than the free molecules (CAPE, MBC and BC). The CH3OH molecules appear as the good ligands to enhance the antioxidant efficiency of chelates. Elsewhere the homolytic H-atom transfer (HAT) mechanism was the likely HO2 radical scavenging process compared to the sequential ones. Therefrom the chelates without ligands were the best antioxidant. Considering the ligands, the chelates of CH3OH were the best antioxidant, mostly Fe(MBC)(CH3OH)42+. However the scavenging of the ionic radical O2 − foresaw that the proton transfer followed by electron transfer (PT–ET) mechanism was the preferred process. This kept the antioxidant potency analyses of HAT mechanism. Moreover, the chelates absorbed the red and the infrared radiations confirming the quality of the antioxidative potency of chelates.
A note on permutation regularity

The existence of a small partition of a combinatorial structure into random-like subparts, a so-called regular partition , has proven to be very useful in the study of extremal problems, and has deep algorithmic consequences. The main result in this direction is the Szemerédi Regularity Lemma in graph theory. In this note, we are concerned with regularity in permutations: we show that every permutation of a sufficiently large set has a regular partition into a small number of intervals. This refines the partition given by Cooper (2006) [10] , which required an additional non-interval exceptional class. We also introduce a distance between permutations that plays an important rôle in the study of convergence of a permutation sequence. ► We address the concept of regularity for permutations. ► For large permutations, we give regular partitions with no exceptional class. ► We introduce a permutation distance based on the concept of quasi-randomness. ► This distance is connected to the convergence of permutation sequences.
Insights from Device Modeling of Perovskite Solar Cells

In this perspective, we explore the insights into the device physics of perovskite solar cells gained from modeling and simulation of these devices. We discuss a range of factors that influence the modeling of perovskite solar cells, including the role of ions, dielectric constant, density of states, and spatial distribution of recombination losses. By focusing on the effect of non-ideal energetic alignment in perovskite photovoltaic devices, we demonstrate a unique feature in low recombination perovskite materials - the formation of an interfacial, primarily electronic, self-induced dipole that results in a significant increase in the built-in potential and device open-circuit voltage. Finally, we discuss the future directions of device modeling in the field of perovskite photovoltaics, describing some of the outstanding open questions in which device simulations can serve as a particularly powerful tool for future advancements in the field.
Localized application of phosphorus and ammonium improves growth of maize seedlings by stimulating root proliferation and rhizosphere acidification

Abstract Root growth of many plant species can be stimulated by localized supply of nutrients such as nitrate, ammonium and phosphorus (P). The ammonium supply can cause rhizosphere acidification by inducing proton release from roots, but little information is available about ammonium and P interaction in improving nutrient use and plant growth through modifying rhizosphere processes in the field. In the present study, maize was grown on a calcareous soil (pH 8.1) in an intensive farming system in North China. To test the hypothesis that localized application of P and ammonium can improve nutrient uptake and plant growth through ammonium-induced rhizosphere acidification, the 2-year field experiment was conducted with the following treatments (N supply as ammonium): localized P application with N broadcast (N B P L ), localized application of both P and N (N L P L ), or both N and P broadcast (N B P B ). Localized supply of P plus ammonium significantly increased chlorophyll content and leaf area, leading to increased dry weight of shoots at early growth stages. The leaf expansion rate was 20–50% higher, the total root length 23–30% greater, and the plant growth rate 18–77% greater in N L P L than N B P B or N B P L treatments at early growth stages. The root-length density at the depth of 0–15 cm was greater in N L P L than N B P L or N B P B , with a greater proportion of fine roots (diameter L P L . Localized supply of P plus ammonium markedly modified rhizosphere processes by stimulating root proliferation (especially of fine roots) and by ammonium-induced rhizosphere acidification, thus significantly increasing acquisition of N and P by plants. Localized application of P combined with addition of ammonium significantly decreased rhizosphere pH (by 3 pH units) in the fertilized zone compared with the bulk soil. The results indicate that localized application of P combined with ammonium can significantly improve maize growth and nutrient use at the early stages by stimulating root proliferation and rhizosphere acidification, suggesting that modifying rhizosphere processes in the field may be an effective management strategy for improving nutrient use efficiency and plant growth.