SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Storm – the story of OrangeInc

Subject area Information Technology Security. Study level/applicability The case adds value for management students at all levels, as well as for practitioners. Work experience is not a requirement, as the case will expose some of the fundamental concepts pertaining to the scenario described. Assignment questions are designed from the perspective of teaching this case to a business student audience. The case could certainly be adjusted to fit the needs of students in more technical disciplines. Case overview Set in October 2008, the case begins with the dilemmas facing Mr Ramanuj as he and his team from E-Infra Solutions prepared to address the damages caused by a major virus attach at OrangeInc headquarter at Bangalore, India. The virus attack destroyed all the important organizational documents residing on the computer systems and brought its business to a standstill. The catastrophe indicated the need for a comprehensive information technology (IT) security solution which was earlier overlooked by OrangeInc's management. Expected learning outcomes To teach the basic concepts of information security, in particular malware, and its impact on the business. To introduce the concepts and the importance of security awareness program. To teach the importance of IT infrastructure technology, process and procedures. Supplementary materials Teaching Notes are available for educators only. Please contact your library to gain login details or email support@emeraldinsight.com to request teaching notes.
LONG LIVED CHIMERIC ANTIGEN RECEPTOR (CAR) EXPRESSING T CELLS FOR CANCER THERAPY

A method of generating an enriched population of T cells for use in adoptive immunotherapy applications includes the isolating CD4/CD8 T-cells from a biological sample of a subject, optionally genetically modifying the isolated CD4/CD8 T-cells to express single or multiple chimeric antigen receptors (CARs), and separating T cells having a CD45RAintCD45ROint phenotype from the optionally genetically modified isolated T cells.
Academic Thought Exploration of Acupuncture in Treatise on Exgenous Febrile Diseases

[Objective] To explore the academic thought of acupuncture and moxibustion of Zhang Zhongjing's as well as provide references for the later generations in clinical practice. [Methods]This paper summarizes the features and regulations of acupuncture and moxibustion from articles in Treatise on Exogenous Febrile Diseases. [Results]Concise information on acupuncture and moxibustion therapies is recorded in book, which exists ten articles for acupuncture, seven for moxibustion with fire, and 18 for syndrome of fire reversal, but very valuable. It is reflected that usable range of acupuncture and moxibustion, acupuncture(moxibustion) added with chinese medcine, preventive treatment of disease, searching for the primary cause of disease in treatment, and so on. [Conclusion]Academic thought of acupuncture and moxibustion of Zhang Zhongjing is of significance for later generations to inherit and develop traditional Chinese medicine, and his contribution to science of acupuncture and moxibustion is eternal.
The law and ethics of war's ending

The project LEWE will seek to develop a moral and legal framework within just war theory for ending wars, and in particular, asymmetric conflicts (for example between states and non-state actors). Just war theory has given little attention to these forms of conflict, or indeed how and when they should end.Currently, no moral theory of conflict termination yet exists. The proposed research is intended to offer such a theory. 
The first aim of the research will be to develop an account of legitimate goals in asymmetric conflicts, which must be considered in necessity, proportionality, and achievability determinations—just war theory’s crucial constraints on war-making. The research will then as a second aim develop criteria to evaluate whether military goals in asymmetric war are necessary, proportionate, and achievable. It will explore the idea that, in asymmetric wars, there need not be a particular point at which a state of hostilities immediately gives way to cease-fire or armistice. Instead it may be possible to identify an interval during which asymmetric wars should be brought to an end, by carefully applying the necessity, proportionality, and probability of success constraints to the goals of war. After deriving the termination framework, the research will assess how its recommendations can be incorporated into international law. This action has the potential to create a broader ethics of peacemaking, distinct from military standards and objectives, that would comprehend morally acceptable goals. Altogether, the current proposal combines the complementary strengths of the researcher and the host to establish the building blocks for a new moral and legal theory of ending asymmetric conflicts, the most prevalent form of war.
REPRESENTAÇÕES DO CONCEITO “PÃO E CIRCO” EM ROMA E NO BRASIL: UM ESTUDO COMPARATIVO

Esta pesquisa teve por objetivo avaliar as diferentes apropriações do conceito “pão e circo” por mídias atuais brasileiras e comparar com o sentido dessa suposta política nas representações latinas e historiográficas. Para tanto, mediante uma abordagem qualitativa, foram utilizados os procedimentos de pesquisa bibliográfica e documental. Esta é composta por fontes primárias do período do Principado Romano, em especial documentos escritos de três autores latinos da aristocracia: Sêneca, Tácito e Juvenal. Além disso, foram analisadas cinco matérias veiculadas em sites eletrônicos de notícias, uma de cada canal selecionado, no contexto da Copa do Mundo de 2018, sendo três editoriais (Manaus Alerta, Terra, Causa Operária) e dois artigos de opinião (Gazeta do Povo, El País). Assim, foi verificado como cada matéria se apropriou e construiu significados para o panem et circenses . Por fim, como resultados, concluiu-se que há diversidade na maneira de entender o papel político e social da Copa do Mundo por parte de cada veículo midiático selecionado, relacionada às suas perspectivas políticas e ideológicas. Também pôde ser observado que muitos dos discursos presentes nas mídias examinadas possuem apropriações dos escritores latinos desta pesquisa, embora essa conexão não seja direta e consciente na maioria dos casos. Tais representações latinas serviram de base à construção da chamada “política do pão e circo” pela historiografia tradicional no século XIX, perspectiva que por vezes encontra terreno em análises sociológicas contemporâneas acerca do futebol no Brasil. Portanto, a presente pesquisa pretendeu refletir sobre as interações entre passado e presente investigando suas diversas apropriações políticas.
An effective and environmentally friendly solution to control fire blight disease caused by erwinia amylovora in pome fruit crops

The PhageFire project is devised to satisfy the unmet need for a secure and reliable solution to control fire blight (FB) disease in pome fruits caused by the bacterium Erwinia amylovora (Ea). The Spanish pome fruit producer, Peras de Rincón de Soto has partnered with Enviroinvest (Hungary) consultancy company expert in production, authorization and commercialization of phage-based pesticides, ZHAW (Switzerland) – a top research centre in phage therapy and Kimitec Group specialist in the design, development and commercialization of natural solutions for the plant protection sector. Together, PhageFire Consortium members aim to further develop an integrated phage-based solution enabling pome fruit farmers to effectively control Ea infections, reducing both production and economic losses. In addition, this will also result on reduced reliance on harmful chemicals (mainly copper-based products) and antibiotics. Based on our advanced current development of phages cocktails and their successful results on the safety and benefits of phages, our goal is to develop and commercialise PhageFire as the first-in-class phage-based biopesticide in Europe providing effective prevention and treatment against Ea infections. In order to take the project forward and reach product commercialization, a next estimated investment of €3.9 M is needed. The successful consecution of the FTI funding will help to cover the 70% (€2.97 M) while the Consortium partners will assume the 30% (€0.93 M) with own funds and the potential economic help from private investors. Considering the increasing demand for FB protection methods, PhageFire biopesticide will represent a great business opportunity (€22.12 M net profit between 2023-2027, ROI 4.66) by filling a highly profitable niche in the growing biopesticide market (CAGR 14.93%, €9.31 B by 2025). Furthermore, the scalable potential of phages will also enable targeting new horizons in plant disease protection.
Automated phenotyping of mouse social behavior

Inspired by the connections between social behavior
and intelligence, I have developed a trainable system to phenotype
mouse social behavior. This system is of immediate interest to
researchers studying mouse models of social disorders such as
depression or autism. Mice studies provide a controlled environment
to begin exploring the questions of how to best quantify social
behavior. For the purposes of evaluating this system and to
encourage further research, I introduce a new video dataset
annotated with five social behaviors: nose-to-nose sniffing,
nose-to-head sniffing, nose-to-anogenital sniffing, crawl under /
crawl over, and upright head contact. These four behaviors are of
particular importance to researchers characterizing mouse social
avoidance [9]. To effectively phenotype mouse social behavior, the
system incorporates a novel mice tracker, and modules to represent
and to classify social behavior. The mice tracker addresses the
challenging computer vision problem of tracking two identical,
highly deformable mice through complex occlusions. The tracker
maintains an ellipse model of both mice and leverages motion cues
and shape priors to maintain tracks during occlusions. Using these
tracks, the classification system represents behavior with 14
spatial features characterizing relative position, relative motion,
and shape. A regularized least squares (RLS) classifier, trained
over representative instances of each behavior, classifies the
behavior present in each frame. This system demonstrates the
enormous potential for building automated systems to quantitatively
study mouse social behavior.
Sharing Experience Europe - policy innovation design

As Europe strives to develop a knowledge-based economy and exploit innovation as a tool for economic growth, it is vital to ensure that innovative ideas actually manifest as successful products and services. Investment in R&D and innovation must be encouraged, but it is equally important for countries to be prepared to convert this knowledge into commercial products and services. Design is seen around the world, particularly in emerging industrial nations outside of Europe, an essential step in the process of transforming innovative ideas into products and services fit for purpose. There is currently a shortfall in this area in most EU countries, particularly within SMEs. The SEE project is a partnership of 11 organisations wishing to establish how this shortfall can  be reduced to best effect by sharing experience, developing new thinking and influencing regional policy.
The group will share information on policies that have been successful in using design to boost innovation, entrepreneurship, sustainability or economic development. All the partners are already active in establishing design programmes or strategies at regional or national levels which target SMEs and their lack of resources for implementing design practice and innovation into their business. This group is now willing to develop an interregional cooperation to exchange information and experiences in order to identify, analyse and disseminate good practices on innovation and design policy and other related areas (e.g. sustainability, R&D).
The partner organisations, from UK, Belgium, Denmark, Estonia, Finland, France, Ireland, Italy, Poland, Slovenia and Spain, alll work as an integral part of regional innovation policy and have commitment from regional government to improve their provision and delivery of policies for innovation, entrepreneurship and design.
The SEE project proposes to operate from July 2008 to June 2011. The project will deliver two Conferences, four Thematic Workshops, a Study Visit, a Collection of Good Practices on Design Policies, six Newsletters, an internal contacts database, four Booklets of Policy Recommendations and 6 short films on policy best practice in this field. The aim of the SEE project is to establish an active dialogue within each region at both an operational and strategic level in order to positively influence regional policies for innovation and design.
Patterned surfaces

The present disclosure provides patterned materials that may be useful in reducing certain negative effects associated with damaged tissue in vivo. The patterned materials can modify the healing process, and may minimize the formation of scar tissue. Such effects can provide inhibition of adhesion between tissues and/or reduction of fibrotic encapsulation around implanted medical devices.
A importância do marketing de relacionamento para construir uma fidelização com os clientes de uma clínica na cidade de Imperatriz- MA / The Importance of relationship marketing to build customer loyalty in a clinic in the city of Imperatriz-MA

Resumo: O presente artigo apresenta a importância da evolução do marketing de relacionamento dentro de uma organização, ligando o consumidor e a instituição, analisando e utilizando o produto, preço, praça e promoção, adquirindo uma visão de construir um relacionamento proporcionando a satisfação aos clientes, buscando sempre a fidelização dos clientes. Tem como objetivo analisar e identificar os impactos gerados no consumidor levando em conta o grande avanço das mídias sociais. Ademais, o trabalho utilizou a pesquisa de campo, quantitativa para levantar informações sobre a visão dos clientes sobre o marketing de relacionamento, proporcionando o conhecimento, desejo e a necessidade do consumidor e na pesquisa bibliográfica, foram utilizados os autores de marketing ampliando ainda mais o conhecimento sobre a utilização do marketing de relacionamento dentro de uma empresa e a sua importância, ampliando o conhecimento e utilizado a internet a seu favor, como foi observado nos resultados positivos obtidos. Palavras-chave: Marketing. Marketing de relacionamento. Evolução do marketing.Abstract: This article presents great importance of the evolution of relationship marketing within an organization, linking the consumer and the institution, analyzing and using the product, price, place and promotion, acquiring a vision of building a relationship providing customer satisfaction, seeking always customer loyalty. It aims to analyze and identify the impacts generated on the consumer taking into account the great advance of social media. In addition, the work used quantitative field research to gather information about the customers' view of relationship marketing, providing the knowledge, desire and need of the consumer and the bibliographic research, several marketing authors were used, further expanding the knowledge about the use of relationship marketing within a company and its importance, expanding knowledge and using the internet in its favor, as observed in the positive results obtained. .Keywords: Marketing. Marketing of relationship. Marketing evolution.
Treating Patients with Metastatic Castration Resistant Prostate Cancer: A Comprehensive Review of Available Therapies

Purpose: The availability of newly approved treatment options for metastatic castration resistant prostate cancer is not matched with conclusive data on optimal sequencing strategies and resistance patterns. A comprehensive review of efficacy and safety data for new agents and current knowledge regarding treatment sequencing would enable treating physicians to make rational drug selections in patients with metastatic castration resistant prostate cancer.Materials and Methods: We searched MEDLINE® and relevant congresses for data on cabazitaxel, docetaxel, 223radium dichloride, abiraterone, enzalutamide and sipuleucel-T, focusing on sequencing strategies, resistance mechanisms and biomarkers of response.Results: Abiraterone and enzalutamide target the androgen axis with different mechanisms of action. Abiraterone blocks cytochrome P450 17, inhibiting androgen synthesis, whereas enzalutamide inhibits androgen receptor, reducing nuclear translocation of the androgen receptor complex and subsequent DNA bindin...
DRILL HEAD FOR DIRECTIONAL BORING

A drill head for an apparatus for directional boring inlcudes a bit having a cutting portion for use in steering, such as a gage tower mounted with carbide studs, suitable for cutting both hard and soft rock, a holder for a device for detecting angular orientation of the bit, and a pneumatic hammer connected head to tail with the bit at the front end. The valve in the hammer initiates reciprocation of the hammer in response to rearward movement of the bit, such as in response to a pushing force exerted by the drill string. The drill string components are preferably keyed to one another so that the orientation of the cutting portion of the bit used for steering is automatically matched to the position of the sonde. The sonde may project laterally so that its mass centroid is on the opposite side of the cutting portion of the bit used for steering to provide better cutting action. Such a drill head is suited for drilling in soil, soft rock and hard rock conditions.
A MATLAB-derived software (geothermMOD1.2) for one-dimensional thermal modeling, and its application to the Corsica-Sardinia batholith

Determination of the thermal state of the crust is of fundamental importance to understand the feedbacks between tectonics, rheology and metamorphism. The most important parameters controlling the variation of temperature with depth in the crust are the heat flow across the Moho, the thermal conductivity and the vertical distribution of heat-producing elements ^2^3^8^,^2^3^5U, ^2^3^2Th and ^4^0K. The Corsica-Sardinia batholith formed during a regional high-temperature metamorphic event by extensive partial melting of the Variscan crust. Petrologic observations indicate that most granites and migmatites formed between 0.6-0.2GPa, requiring the geotherms to flatten substantially relative to the stage of crustal thickening. The adjustment of geotherms may be interpreted in terms of enrichment in heat-producing elements or, alternatively, in terms of increased mantle contribution. The validity of these two end-member hypothesis has been tested by performing numerical experiments with a software package appositely developed in Matlab. The software allows to set up crustal model composed of up to five different layers, and to plot the calculated geotherm along with the stability field of the haplogranite system and other thermo-barometric constraints. The steady-state thermal structure of the Sardinian Variscan crust has been computed at four different time steps (320, 310, 300, and 280Ma), which cover the batholith evolution. The geometry and composition of each of these crustal models has been constrained based on geophysical observations, geochronology and petrology. In a first experiment, the heat conduction equation has been solved for all of the four time-steps, assuming constant (15mW/m^2) heat flow across the Moho in order to simulate a 'fully crustal' evolution of the thermal structure. The alternative has been simulated in a second experiment, by rising the basal heat flow up to 40mW/m^2 during the last two time steps.
PAPERS CONTAINING FLOC DERIVED FROM DIAMINO DIPHENYL SULFONE

This invention relates to papers made with floc containing a polymer or copolymer derived from a monomer selected from the group consisting of 4,4'diaminodiphenyl sulfone, 3,3'diaminodiphenyl sulfone, and mixtures thereof. Such papers have higher elongation-at-break and work-to-break (toughness) properties and exhibit less shrinkage at high temperatures than papers made with solely with poly (metaphenylene isophthalamide) floc.
CANDLE SYNDROME: Orofacial manifestations and dental implications

A South African girl with CANDLE Syndrome is reported with emphasis on the orodental features and dental management. Clinical manifestations included short stature, wasting of the soft tissue of the arms and legs, erythematous skin eruptions and a prominent abdomen due to hepatosplenomegaly. Generalized microdontia, confirmed by tooth measurement and osteopenia of her jaws, confirmed by digitalized radiography, were previously undescribed syndromic components. Intellectual impairment posed problems during dental intervention. The carious dental lesions and poor oral hygiene were treated conservatively under local anaesthetic. Prophylactic antibiotics were administered an hour before all procedures.Due to the nature of her general condition, invasive dental procedures were minimal. Regular follow-ups were scheduled at six monthly intervals. During this period, her overall oral health status had improved markedly.The CANDLE syndrome is a rare condition with grave complications including immunosuppression and diabetes mellitus. As with many genetic disorders, the dental manifestations are often overshadowed by other more conspicuous and complex syndromic features. Recognition of both the clinical and oral changes that occur in the CANDLE syndrome facilitates accurate diagnosis and appropriate dental management of this potentially lethal condition.
Privacy, ethical, regulatory and social no-gate crossing point solutions acceptance

The increasing number of travellerscrossing European borders is putting a mounting pressure on the everyday handling of border checks. Coping with limited resources, border control authorities have to perform a higher number of checks on travellers, while at the same time maintaining national security. Consequently, the experience of both European and third country travellersis deteriorating, due to the extra time they have to spend at the border crossing points. In that sense, flexible, automated and scalable no-gate crossing solutions may offer an effective support to border control authorities, to make border checks faster and more efficient. Nevertheless, the intensive use of these technologies bears the risk of infringing individuals’ rights and freedoms, including privacy and personal data protection. Therefore, a thorough assessment of no-gate crossing point solutions, from asocial acceptance, ethical and legalperspective, is required prior to their implementation. PERSONA (Privacy, Ethical, Regulatory, and SOcial No-gate crossing point solutions Acceptance) project’s main goal is to design and establish an integrated impact assessment method (IAM PERSONA) to appropriately evaluate the impacts of no-gate crossing point solutions, taking into account social acceptance, ethical and legal requirements, to ensure that these technologies meet the expectations of public authorities and travellers. The main outcome of the project will be a handbook, available in open access, that will provide guidance inorder to drive the innovation and deployment of future no-gate crossing point solutions by industry and border authorities, while maintaining their societal acceptance