SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Radiative transfer of elastic waves in two-dimensional isotropic scattering media: Semi-analytical approach for isotropic source radiation

We formulate the radiative transfer of P- and S-wave energy from an isotropically radiating source in a two-dimensional infinite isotropic scattering medium. For a stable numerical calculation of seismogram envelopes, we take a semi-analytical approach: Energy densities of P and S waves are divided into three parts of the direct-wave terms, the single-scattering terms, and the multiple-scattering terms, and the first two terms and the last term are evaluated analytically and numerically, respectively. Concerning the single-scattering terms, the P- to-S and S-to-P single conversion scattering terms are expressed analytically with a complete elliptic integral of the first kind. The multiple-scattering terms are represented by a double integral with respect to frequency and wavenumber, and can be numerically evaluated by a discrete wavenumber summation and a Fast Fourier Transform. The results based on the numerical implementation are confirmed with an independent numerical calculation using the Monte Carlo method. Our formulation is also applied to consider the equilibration between P and S waves at larger lapse times. The equilibrated S-to-P energy ratio is reproduced and the equilibration time is first derived for two-dimensional cases. Our formulation will be a reference for the understanding of more complex cases.
Performance evaluation of lifting entry guidance for hypersonic vehicles

Aimed at the requirements and characteristics of hypersonic lifting entry vehicles, the paper brings forward the performance evaluation indexes of entry guidance, establishes the numerically scored models of performance evaluation indexes, and designs a total of 26 kinds of test missions named EG1 to EG26. According to the test cases, by means of the Monte Carlo dispersions and the individual constant disturbance simulation, each performance index of entry guidance is numerically scored. Based on the weighted allocation strategy, a comprehensive evaluation on entry guidance law can be completed. Finally, the concrete steps and process about the evaluation method of entry guidance performance is given, which can be an important references and basis of performance evaluation on entry guidance for a class of lifting vehicles.
Make Creative Villages - Initiate Cooperation between CCI and Villages

Actors in rural areas often lack innovation competences and the methods to initiate cooperation with innovative enterprises. Thus, companies from the creative industries have only occasionally been seen as a potential cooperation partner for villages to develop their manifold local cultural resources and to find innovative ideas to preserve the attractiveness of the region.
Creative industry in rural areas is an untapped potential in Central Europe. Developing the creative sector in rural areas has the potential to generate sustainable and quality enterprises as well as employment opportunities and contribute to rural diversification.
This is where the project Mac Village starts. The main objective of the project is to develop an easy-to-apply methodology in an iterative process for the local and regional level to initiate innovations in cooperation with CCI enterprises. Basis is the Frugal Innovation concept which responds to limitations in resources, which are also found in rural areas. A range of innovation methods will be tested in three villages per partner region and further developed. The methods are easy to use and promote a rapid and joint development of competence and innovative networking. The project brings together people from different fields (local authorities and stakeholders, regions, business development agencies and organisations with specific competence in CCI and social entrepreneurship) and gathers them in a multi-level dialogue.
The project will implement 54 innovation workshops in six regions in DE, AT, IT, SI and HU promoting the cooperation among local actors and CCI. More than 200 stakeholders will be trained to enable them to implement the innovation methods developed in the project. By doing so local actors in the villages will be able to create favorable local conditions for CCI and innovative networks for new products and services exploiting their cultural resources and develop new businesses.
Detection of Coliforms in Drinking Water Using Skin Patches: A Rapid, Reliable Method that Does Not Require an External Energy Source

The detection of coliforms requires incubation in a laboratory, generally powered using electricity. In many parts of the developing world, however, external energy sources such as electricity are not readily available. To develop a fast, reliable method for detecting coliforms in water without an external energy source, we assessed the efficacy of six test kits for the identification of coliforms in water samples. To assess the possibility of using body temperature as the sole source of heat for incubation, bacterial samples were then mixed with the enzymatic test kit reagent and attached to the human body surface using a patch system. The patches were attached to the bodies of volunteers for 24 hours and the practicality and accuracy of the patches were assessed. Coliforms were detected within 24 hours in all patches. This innovation will facilitate the testing of water quality by researchers and by economically disadvantaged people without electricity.
Proportional sharing and DEA in allocating the fixed cost

This paper investigates the relationship between the proportional sharing method and DEA technology in solving the problem of allocating the fixed cost of a jointly used common platform among its users. It first examines the basic concept of equity of the proportional sharing method in the one dimensional case which motivates the analysis and extends proportional sharing to the general multiple-input multiple-output case. Then, it has proven that the necessary and sufficient condition for the existence of the proportional sharing is that all users can be DEA efficient with a common set of weights. Furthermore, this paper investigates the relationship between the extended proportional sharing method and some other DEA-based allocation approaches. Based upon these theoretical foundations, this paper proposes an alternative cost allocation approach, and applies it to a data set from prior DEA literature.
Growth and differentiation factors for periodontal regeneration: a review on factors with clinical testing

A large body of evidence implies that growth and differentiation factors, based on their ability to regulate various functions of cells originating in the periodontal tissues, may support periodontal wound healing/regeneration, creating an environment conducive to and/or immediately inducing de novo tissue formation. This study presents a short systematic overview on growth and differentiation factor technologies evaluated in the clinic for their potential to enhance periodontal wound healing/regeneration.Reports on growth and differentiation factor technologies evaluated in the clinic for their potential to enhance periodontal wound healing/regeneration were selected for review.Growth and differentiation factor technologies intended for periodontal wound healing/regeneration and evaluated clinically included platelet-derived growth factor, insulin-like growth factor-I and -II, basic fibroblast growth factor, bone morphogenetic protein-3 and growth differentiation factor-5; platelet-derived growth factor was the only Food and Drug Administration-approved commercially available growth and differentiation factor technology. In general, enhanced periodontal regeneration was observed in sites receiving growth and differentiation factors compared with control(s). However, improvements of relatively limited clinical magnitude have been shown thus far.Although growth and differentiation factors project considerable appeal as candidate technologies in support of periodontal wound healing/regeneration, current candidate and commercially available technologies enhance treatment outcomes only to a limited extent in clinical settings.
interoperability

"This project is part of the plan CLIP" The project pursues an objective of cross-border numerical innovation, which will be globalized and will allow to face difficulties of cross-border interconnection. The interconnection of existent numerical infrastructures or in construction is an opportunity to furnish integrated services accessible in situation of mobility on both sides of the border. The furniture of these new services will allow to share information of use and for some open-data data. The project is built on two axes which promote innovation over territory: infrastructures interconnection and a support platform for numeric services.

CLIP’s plan aims to create conditions for a long-term development of a cross-border system of innovation. The strategy purposed is based on the accessibility of numerical infrastructures systems and data sharing, the access to new innovative services for PMI, and the implementation of new services in the e-health sectors and of the e-mobility. This plan is articulated on three projects, deicated to test and develop innovative services for industries (Circuito), for health sector (E-Santé and silver economy) and for mobility in cross-border era (e-transport). The fourth project “interoperability” needs to furnish in a cross-border manner a sustain for the development of stockage systems and the sharing of datas on both sides of the border, but also for the development of a web cross-border platform dedicated to the distribution of developed services by three other projects.
Applying energy efficient measures for metal and metalworking smes and industry

EE-METAL aims to provide enterprises with innovative technical, commercial and financial tools in order to overcome the existing barriers that hinder the adoption of energy saving measures. EE-METAL actions are mainly targeted to Metalworking and Metal Articles (MMA) SMEs, given that this sector is the biggest manufacturing sector in Europe and it is mostly composed by SMEs. EE-METAL actions will focus on overcoming: 

Awareness, information and technical capacity barriers to identify, evaluate and implement energy efficiency actions: EE-METAL will adapt and standardize for the sector existing methods and technologies such as energy audits, the standard ISO 50.001 and the use of Energy Monitoring Systems.

Commercial and market barriers to the contracting of energy service companies (ESCos): development of a benchmarking study of energy service contracts and the role of ESCOs in the MMA and other industrial sectors; networking with ESCOs Associations for fostering ESCOs-SMEs contracts.

Financial barriers to the implementation of energy saving measures: benchmarking the different financial models being implemented in the partner countries for financing energy saving institutions for providing clear information on type and size of investments needed.

These two last actions will allow put in place mechanisms for funding the energy efficiency projects identified in the first action. In this sector, big energy savings can be obtained by the aggregation of many smaller savings.

Furthermore five out of the seven project partners are Enterprise/Trade Associations (with 7000 associated companies) that will ensure that a critical mass is achieved.

EE-METAL is in line with the following EU strategies and initiatives: first priority of the EU Energy 2020 Strategy for Achieving an energy efficient Europe; Energy efficiency plan 2011 (COM (2011) 109); A strategy for competitive, sustainable and secure energy (COM (2010) 639 final) and Directives 2012/27/EU-2
A geomagnetic field model for the Holocene based on archaeomagnetic and lava flow data

Abstract We propose a new geomagnetic field model for the Holocene period based on archaeomagnetic and lava flow data, avoiding the use of lake sediment data. The source of data comes from the GEOMAGIA50v2 database which has been updated with the new archaeomagnetic and volcanic studies published during the last 3 yr. The model, called SHA.DIF.14k, allows us to analyse the behaviour of the geomagnetic field for the last 14 000 yr: from 12 000 BC to 1900 AD. For the model construction we use the spherical harmonic analysis in space and the penalized cubic B-splines in time. Both spatial and temporal regularization norms are used to constrain the inversion problem and applied at the core–mantle boundary (CMB) to assure the convergence of the model. For the last 3 ka, the model predictions agree with those given by the global model ARCH3k.1 and the European model SCHA.DIF.3k. For older epochs, the new model presents a clear improvement in field resolution with respect to other current models of the geomagnetic field for the Holocene. For the last 9 ka, the time evolution of the dipolar moment obtained from the dipole field shows a clear minimum between 5500 BC and 3000 BC, and the well-known continuous decreasing trend of the geomagnetic field strength for the last millennium and a half. A general view of the time-average evolution of the geomagnetic field flux lobes at the CMB for the northern hemisphere suggests a marked lobe of positive magnetic flux when the dipole moment was maximum. This lobe vanishes when the dipolar field is decreasing. The north polar wander paths of both north magnetic dip and geomagnetic poles were obtained showing an average rate of motion of 5.1 km/yr and 3.7 km/yr respectively. The model shows that the geomagnetic field can be averaged as axial dipolar in ∼ 2000 yr within an error of 5°, the typical uncertainty of the palaeomagnetic studies. Finally, and following the recent definition of archaeomagnetic jerks, we found 8 critical events in the time evolution of the geomagnetic field for the last 8 ka characterized by a maximum in the hemispheric asymmetry of the proposed model. The model is available in the Earth Ref Digital Archive at http://earthref.org/ERDA/1897/ .
Association of prenatal organochlorine pesticide-dichlorodiphenyltrichloroethane exposure with fetal genome-wide DNA methylation

To investigate whether intrauterine organochlorine pesticide (OCP)-dichlorodiphenyltrichloroethane (DDT) exposure could lead to epigenetic alterations by DNA methylation with possible important lifetime health consequences for offspring.We used Illumina Infinium HumanMethylation 450 K BeadChip to explore the pattern of genome-wide DNA methylation containing >485,000 gene sites in cord blood of 24 subjects in a 12 mother-newborn pairs birth cohort. Based on the genome-wide DNA methylation data, we chose one potential gene, BRCA1, to verify the results in another group comprising 126 subjects.We identified 1,131 significantly different CpG sites which included 690 hypermethylation sites and 441 hypomethylation sites in the DNA methylation level between case and control group. The identified sites were located in 598 unique genes. In subsequent validation studies, we found that the DNA methylation level of the identified CpGs of BRCA1 increased with increased exposure to dichlorodiphenyltrichloroethane (DDT) and the level of gene expression in the identified CpGs of BRCA1 decreased with increased exposure to dichlorodiphenyltrichloroethane (DDT).The results indicated that epigenetic processes played a possible role in the development of fetuses affected by maternal OCP-DDT exposure. Early prenatal exposure to DDT may affect fetal BRCA1 gene methylation, and increased exposure leads to a higher DNA methylation level and lower gene expression level.
Novel hybrid thermoelectric photovoltaic devices: modeling, development, and characterization

This project aims at the practical realization, the characterization, and the industrial/commercial evaluation of optimized hybrid thermoelectric-photovoltaic (HTEPV) devices. HTEPV devices can convert the solar energy more efficiently than normal solar cells, since the thermoelectric component recovers part of the unused heat generated within them. In this project the hybrid optimization will be obtained with an innovative approach recently proposed within a theoretical/computational study by the fellow, Dr. Bruno Lorenzi. The principal objective of this action will be the practical hybridization of two kinds of single junction solar cells in HTEPV devices achieving performances higher than the PV cell alone by at least 25%. The project will be organized in three main phases: outgoing phase (first HTEPV development), ingoing phase (second HTEPV development), and a secondment (encapsulation development at a non-academic institution). Dr. Lorenzi will acquire knowledge and know-how especially by training through research in achieving the objectives of the action. This will contribute to make Dr. Lorenzi an independent and expert researcher in the perspective of his future research carrier. The project will also surely contribute to the advance of field of the energy harvesting. Actually it is well known that for renewables, the higher the efficiency the lower is the total-cost/produced-power ratio. Thus the large expected increase of efficiency for the hybrid devices developed in this action will have a major impact on their price per watt. This will open new concrete possibilities for near-future commercialization of this novel generation of solar harvesters, stimulating industrial productions and new markets. This in turn will lead to a wider diffusion and a higher accessibility of a renewable source of energy for the EU citizens.
DEVICES AND METHODS FOR UNWRAPPING OR PREVENTING THE WRAPPING OF ELONGATED MEDICAL DEVICES

Devices and methods for unwrapping (or otherwise overcoming the entanglement of), or preventing the wrapping of, guidewires and similar elongated medical devices deployed (or about to be deployed) in vessels of a patient. Embodiments have sufficient flexibility to be deployed by distally threading at least one lumen over a guidewire, and sufficient torqueability to enable axial rotation of the combination to unwrap the entangled devices or prevent further entanglement as additional guidewires are advanced through other lumens.
Processing of emotional information in the human subthalamic nucleus

The subthalamic nucleus (STN) is an efficient target for treating patients with Parkinson's disease as well as patients with obsessive-compulsive disorder (OCD) using high frequency stimulation (HFS). In both Parkinson's disease and OCD patients, STN-HFS can trigger abnormal behaviours, such as hypomania and impulsivity.To investigate if this structure processes emotional information, and whether it depends on motor demands, we recorded subthalamic local field potentials in 16 patients with Parkinson's disease using deep brain stimulation electrodes. Recordings were made with and without dopaminergic treatment while patients performed an emotional categorisation paradigm in which the response varied according to stimulus valence (pleasant, unpleasant and neutral) and to the instruction given (motor, non-motor and passive).Pleasant, unpleasant and neutral stimuli evoked an event related potential (ERP). Without dopamine medication, ERP amplitudes were significantly larger for unpleasant compared with neutral pictures, whatever the response triggered by the stimuli; and the magnitude of this effect was maximal in the ventral part of the STN. No significant difference in ERP amplitude was observed for pleasant pictures. With dopamine medication, ERP amplitudes were significantly increased for pleasant compared with neutral pictures whatever the response triggered by the stimuli, while ERP amplitudes to unpleasant pictures were not modified.These results demonstrate that the ventral part of the STN processes the emotional valence of stimuli independently of the motor context and that dopamine enhances processing of pleasant information. These findings confirm the specific involvement of the STN in emotional processes in human, which may underlie the behavioural changes observed in patients with deep brain stimulation.
Mechanical regulation of cellular behaviour in 3d viscoelastic materials

Extracellular matrix (ECM) mechanical properties have emerged as key promoters of processes such as cell migration and epithelial to mesenchymal transition (EMT) in cancer. Despite recent advances in the understanding of cellular ECM sensing machinery, mimicking tissue microenvironments in vitro is highly challenging, and most research has been focused on two dimensional (2D) elastic substrates. However, ECMs are not merely 2D elastic substrates, but rather viscoelastic three dimensional (3D) materials. Our objective is to understand how the viscoelastic properties of 3D ECMs regulate cell behaviour. We hypothesize that in viscoelastic materials, counter-intuitively, an increase in viscosity triggers force transduction and gene expression, due to an increase in the load of molecular clutches formed between the ECM and actin. To address the influence of viscoelasticity, Alberto Elosegui-Artola (the experienced researcher/ Applicant) will develop a set of hydrogels matching the viscoelastic properties of both healthy and malignant breast tissue. Then, traction force microscopy will be developed and combined with molecular biology techniques to determine the molecules involved in 3D viscoelasticity sensing. The dynamic behaviour of these molecules will be integrated in a 3D molecular clutch model with the aim to predict cellular migration and force transduction. Model predictions will be validated by performing experiments in 3D viscoelastic gradients on the migration of single cells and spheroids. Lastly, the relevance of the model will be tested by observing if impairing model-predicted force transduction elements prevents EMT transition in cell lines and mouse-derived breast healthy and tumour organoids. This project’s results are expected to reveal molecular interactions that could lead to new therapeutic targets in breast cancer, and also to provide translational opportunities in other disciplines including biomaterials and regenerative medicine.
Multi-Modal tensor tomography

Capture structures without looking at them directly, but rather by probing their interaction with electromagnetic waves - this is the basic principle for the new multi-modal tensor tomography developed in this research programme. It will enable to study the arrangement of nanostructures in macroscopic samples, six orders of magnitude larger than its building blocks, allowing to apprehend the structure of complex hierarchical materials. 
I will use visible light observing change in their polarization state as well as the scattering of hard X-rays to probe nanostructure. Both modes capture alignment of nanostructure, while complementary in other aspects e.g. high penetration depth of synchrotron radiation and easy accessibility of laboratory polarimetric setups. 
At the core of MUMOTT lays the development of the methodological framework implemented in an open-source software package allowing for the reconstruction of tensors in each sub-volume or voxel of the three-dimensional tomogram. Whereas in a first step I will work out a general approach, we will incorporate flexible modules to capture details of the different types of interaction. This approach includes method development pushing the boundaries of traditional synchrotron methods to make full use of the high brilliance and coherence of the new generation of synchrotrons coming online as well as the enabling of studies with lab-based equipment. It opens up for addressing new scientific problems by widening the range of materials as well as the user community. 
Apart from the methodology framework we will implement the different modes to prove their capability to solve critical problems in materials and bio-science; to investigate the structure of light-weight composites based on cellulose nanofibrils, reveal how the arrangement of nanoparticles in a plasmonic composite is connected to its sensing capabilities, as well as shed light on the disruptive collagen network in liver fibrosis.