SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Boolean weightless neural network architectures

A collection of hardware weightless Boolean elements has been developed. These form fundamental building blocks which have particular pertinence to the field of weightless neural networks. They have also been shown to have merit in their own right for the design of robust architectures.
A major element of this is a collection of weightless Boolean sum and threshold techniques. These are fundamental building blocks which can be used in weightless architectures particularly within the field of weightless neural networks. Included in these is the implementation of L-max also known as N point thresholding. These elements have been applied to design a Boolean weightless hardware version of Austin’s ADAM neural network. ADAM is further enhanced by the addition of a new learning paradigm, that of non-Hebbian Learning. This new method concentrates on the association of ‘dis-similarity’, believing this is as important as areas of similarity.
Image processing using hardware weightless neural networks is investigated through simulation of digital filters using a Type 1 Neuroram neuro-filter. Simulations have been performed using MATLAB to compare the results to a conventional median filter. Type 1 Neuroram has been tested on an extended collection of noise types. The importance of the threshold has been examined and the effect of cascading both types of filters was examined. 
This research has led to the development of several novel weightless hardware elements that can be applied to image processing. These patented elements include a weightless thermocoder and two weightless median filters. These novel robust high speed weightless filters have been compared with conventional median filters.
The robustness of these architectures has been investigated when subjected to accelerated ground based generated neutron radiation simulating the atmospheric radiation spectrum experienced at commercial avionic altitudes. A trial investigating the resilience of weightless hardware Boolean elements in comparison to standard weighted arithmetic logic is detailed, examining the effects on the operation of the function when implemented on hardware experiencing high energy neutron bombardment induced single event effects.
Further weightless Boolean elements are detailed which contribute to the development of a weightless implementation of the traditionally weighted self ordered map.
The fate and therapeutic potential of human neoantigen-specific t cells

Cancer is a global health burden and the second leading cause of death worldwide. In recent years, the development of immunotherapy has revolutionised the approach to cancer therapy. A significant limitation, however, is that it is only effective in a subset of patients and the biggest challenges remain the identification of immunogenic targets on human cancers and overcoming immunosuppression. Neoantigens, which are newly formed antigens that arise from mutated tumour proteins, are promising targets in immunotherapy. With the proposed project, we aim to investigate the immune response against human neoantigens which will be induced in a novel humanised tumour mouse model. This unique mouse model harbours the entire human CD8 TCR repertoire and expresses human HLA-2. We will test whether human neoantigens can elicit spontaneous anti-tumour T cell responses in acute inflammatory versus resting conditions, ultimately leading to tumour rejection. We hypothesise that T cells are not able to reject tumours in absence of acute inflammation, similar to the development of most human cancers. To investigate why neoantigen-specific T cells become dysfunctional and fail to reject tumours, we will characterise the functional state and metabolic phenotype of neoantigen-specific T cells by flow cytometry, metabolomics and TCR sequencing. In addition, we will characterise the TCR repertoire of T cells that cause tumour rejection under acute inflammatory conditions. Lastly, we will compare the therapeutic efficacy of adoptively transferred T cells transduced with newly identified TCRs with neoantigen-based vaccines against large established tumours. Overall, this project will contribute to the understanding of immunosurveillance and establish novel techniques to test predicted neoantigens. The identification of human immunogenic targets has the potential to make a global impact on cancer intervention.
Building Local Capacity for Training and Coaching Data-Based Problem Solving With Positive Behavior Intervention and Support Teams

Positive Behavior Intervention and Support Teams use data to guide decisions about student social and academic behavior problems. In previous evaluation and research efforts, the authors taught team members to use Team-Initiated Problem Solving, a model that embeds data-based decision making into a broader problem-solving framework. In this study, the authors taught local trainer/coaches to deliver the problem-solving workshop to Positive Behavior Intervention and Support Team members. Trainer/coaches delivered the workshop and follow-up technical assistance with fidelity, and team members subsequently (a) used the problem-solving procedures in their meetings and (b) perceived positive differences between their pre- and postworkshop meetings. The study provides support for developing local capacity to deliver training and coaching, in particular as it concerns data-based decision making and problem solving.
Development and implementation of the Rapid Discharge Pathway Version 12 to enable imminently dying patients to die in the place of their choice

This study reports on the further development and implementation of a Rapid Discharge Home to Die Care Pathway (RDP Version 12). A rapid discharge pathway (RDP) was originally developed by members of the Hospital Specialist Palliative Care Team at the Royal Liverpool and Broadgreen University Hospitals NHS Trust in response to an identified clinical need to enable imminently dying patients to die in their place of choice when a clinical situation has changed rapidly and there has been an urgent request for a patient to die at home. The initial development and early evaluation, along with an example of the pathway itself, was published in 2004. The current study reports specifically on the subsequent development of the pathway that occurred alongside that of the generic Version 12 of the Liverpool Care Pathway for the Dying Patient published in December 2009. The study outlines the process of development and implementation of the RDP Version 12; patient scenario and a completed example are included to further illustrate the circumstances in which it can be used and the resultant process.
METHODS AND APPARATUS FOR REVERSE CIRCULATION CEMENTING OF CASING STRINGS IN WELLBORES

Methods and devices for completion of well bores and more particularly, to reverse circulation cementing of casing strings in well bores are provided. One example of a method may comprise a method for providing fiuidic access to an outer annulus of a casing string within a well bore. One example of a device may comprise a casing hanger (110), the casing hanger comprising a fluid port (120) wherein the fluid port provides fiuidic access to an outer annulus (150) by allowing fluid to pass through the casing hanger; a landing sub (130) attached to the casing hanger; and an isolation device (140) attached to the landing sub wherein the isolation device is adapted to allow fiuidic isolation of a portionof the landing sub from a portion of the outer annulus of the well bore.
Do shareholder protection and creditor rights have distinct effects on the association between debt maturity and ownership structure?

This study examines the effects of the firm's ownership concentration and its institutional environment on corporate debt maturity choices. As ownership concentration and debt maturity are alternative governance mechanisms, we theorize and investigate whether their association is influenced by country‐level governance factors that enhance outside monitoring by minority shareholders and debtholders. Our investigation is based on a dataset of 50,599 firm‐year observations from 38 countries. We use a propensity‐score matching approach and find that the effect of ownership concentration on debt maturity is conditional to country‐level governance attributes. Ownership concentration has a negative effect on debt maturity in countries where both shareholder protection and creditor rights are weak. Ownership concentration, however, tends to lengthen debt maturity as protection increases, and this positive effect on the length of debt maturity is stronger in countries enhancing protection towards debtholders (instead of shareholders). We also explore other characteristics of ownership structure, such as the identity and presence of controlling shareholders. These results corroborate the view that entrenched shareholders may use debt maturity opportunistically. Our study provides new insights into the interplay between firm‐ and country‐level governance mechanisms and a deeper understanding of cross‐country differences in the association between ownership structure and debt financing.
Sleep microstructure in parkinson's disease and rem-sleep behavior disorder

Idiopathic REM sleep Behavior Disorder (iRBD), a condition characterized by abnormal behaviors during sleep associated with dream enactment, is considered a prodromal state of Parkinson’s disease (PD). Both disorders share a common pathophysiology consisting of abnormal protein deposition from the gastrointestinal tract to the brain via ascending pathways. Whereas motor aspects have been extensively studied in iRBD/PD, a comprehensive view of the effects of the pathology on sleep-wake microarchitecture is still lacking. This Sleep_PD-RBD project focuses on the sleep disturbances associated with iRBD/PD and what they may reveal about the neurodegenerative process. Besides characterizing alterations in vigilance state regulation and sleep oscillations, I will correlate these EEG observations to gastrointestinal symptoms and daytime sleepiness, which both greatly impair patients’ quality of life. The original aspect of this project consist of studying sleep alterations with the recent concept of sleep and wake as non-mutually exclusive states, emphasizing sleep-wake dynamics as opposed to sleep scoring with conventional polysomnography variables, and with innovative EEG analyses investigating the properties of specific sleep oscillations and their cross-coupling. The project also links the brain to the guts, a current hot research topic. This multi-disciplinary project will rely on retrospective databases of patients obtained in Lyon and collaborative centers across France, as well as ongoing recruitment of patients and controls. For this project, I will benefit from the strong expertise of the Lyon Neuroscience Research Center in neuroscience research and of the Center for Sleep Medicine and Respiratory Diseases of Lyon University Hospital for clinical research aspects. With this fellowship, I aim to reintegrate the French academic network in an ideal research setting to learn technical and team-leadership skills and grow into a qualified independent researcher.
Effects of food price shocks on child malnutrition: The Mozambican experience 2008/2009

A propitiously timed household survey carried out in Mozambique over the period 2008/2009 permits us to study the relationship between shifts in food prices and child nutrition status in a low income setting. We focus on weight-for-height and weight-for-age in different survey quarters characterized by very different food price inflation rates. Using propensity score matching techniques, we find that these nutrition measures, which are sensitive in the short run, improve significantly in the fourth quarter of the survey, when the inflation rate for basic food products is low, compared to the first semester or three quarters, when food price inflation was generally high. The prevalence of underweight, in particular, falls by about 40 percent. We conclude that the best available evidence points to food penury, driven by the food and fuel price crisis combined with a short agricultural production year, as substantially increasing malnutrition amongst under-five children in Mozambique.
Enhancing innovation management capacities of smes in montenegro

Enterprise Europe Network is a main support instrument for innovation in SMEs. It will provide innovation support services as well as information and advisory services such as mentoring, coaching and partner search activities for SMEs wishing to develop cross-border innovation projects.
Innovation support, as a service that EEN Montenegro will deliver, will be offered through two packages - Key Account Management (KAM) to support the innovation capacity of successful “SME instrument” applicants benefiting from Horizon 2020 specific supporting mechanism, and Services to enhance the innovation management capacity of SMEs in Montenegro in order to improve their effectiveness and efficiency, in particular aimed at those with significant innovation activities and a real potential for international growth.
Aumentare la competitività dell'azienda introducendo un innovativo servizio di versare succhi e bevande arricchiti con ingredienti sani con proprietà salutari, per lo sviluppo di Specializzazione Intelligente Regionale — Agricoltura Moderna e Lavorazione Alimentare.

L'obiettivo del progetto è quello di introdurre sul mercato un servizio innovativo di versare succhi e bevande con proprietà salutari, confermato dal parere sull'innovazione. Oggetto del progetto è l'acquisto di un pastorizzatore succo per il lancio di un prodotto innovativo (servizio) e l'acquisto di un impianto fotovoltaico. Un'ampia analisi delle esigenze e della concorrenza, che è stata inserita nel Piano Industriale, mostra la legittimità di sostenere l'attuazione dell'investimento. Periodo di attuazione del progetto: Inoltre, l'obiettivo del progetto è aumentare l'uso dell'innovazione nelle imprese nel settore delle PMI, in linea con l'obiettivo principale della misura 2.5 del RPOWŚ. Il progetto è in linea con le disposizioni dell'accordo di partenariato, RPOWŚ 2014-2020, SZOOP 2014-2020, gli obiettivi specifici dell'asse prioritario 2-economia competitiva, misura 2.5 del RPOWŚ 2014-2020. Il progetto aumenterà l'occupazione nella società — 1 a tempo pieno, che contribuirà alla riduzione della disoccupazione nel Voivodato di Świętokrzyskie. Il progetto è conforme ai principi orizzontali dell'UE. Gli obiettivi del progetto saranno raggiunti attraverso l'attuazione di indicatori di output, vale a dire Investimenti (...) [CI 6], — 61 536,56 Numero di imprese sostenute per introdurre nuovi prodotti per il mercato [CI 28] [pz.] -1, numero di imprese sostenute per introdurre nuovi prodotti per l'impresa [CI 29] [pz.] -1, numero di imprese beneficiarie di sovvenzioni [CI 2] [imprese] — 1, numero di imprese beneficiarie di sostegno [CI 1] [pz.] -1, e indicatori di risultato cioè. Numero di innovazioni di prodotto introdotte [pz.] -1, Numero di innovazioni di processo introdotte [pz.] -Aumento dell'occupazione nelle imprese sostenute (CI 8) [EPC] — 1.
Travelling the flavour trail: in the countryside

This project undertakes a major survey on the promotional initiatives carried out in the territory concerned, in order to define a strategy to rationalize and enhance such initiatives and in order to exploit to the full their potential, for they are significant supports of the rural and territorial development. The first stage envisages the analysis of the initiatives carried out in the territory and managed by the project partner’s local administration. Then a survey shall be performed on the Venetian territory potential in terms of typical and traditional products. On completion of the analysis, the best operative strategies shall be detected, in order to enhance the initiatives at issue and to foster their role in data and information dissemination about the territory. The project concerns different kinds of initiatives, which have already been tested on the ground: the “olive harvesting feast” in Isola-Izola, the “Goose festival” in Mirano, “S. Andrea fair” in Portogruaro, “Christmas in the countryside” in Campagna Lupia and the “Radicchio festival” in Mirano. Moreover, the agricultural situation of the Livenza-Tagliamento and Brenta-Dese areas shall be studied, whilst detecting the quality products to be found in the two areas and their seasonality. The project is going to enhance the most significant activities in the area; the final results expected are the increase in the visibility of the typical products promoted by the initiatives included in the circuit and a more effective promotion of the initiatives.
The Clinical Effectiveness of Ranibizumab Treat and Extend Regimen in nAMD: Systematic Review and Network Meta-Analysis

Neovascular age-related macular degeneration (nAMD) is a chronic eye condition that causes severe deterioration of vision and ultimately blindness. Two vascular endothelial growth factor inhibitors are approved for nAMD treatment in Europe: ranibizumab and aflibercept. The European license for ranibizumab was updated with an individualized "treat and extend" (T&E) regimen, which involves more proactive treatment based on changes in best corrected visual acuity (BCVA) and/or anatomical outcomes. The aim of this publication is to compare the efficacy of the ranibizumab T&E regimen with other approved dosing regimens for nAMD on the basis of outcomes identified from a systematic review and subsequent NMA.Following a systematic search of publications, to identify relevant studies, a repeated-measures network meta-analysis (NMA) was performed to estimate the relative effectiveness of ranibizumab T&E versus approved dosing regimens of ranibizumab and aflibercept. The analysis focused on licensed treatment regimens for nAMD. We examined mean change from baseline in BCVA on the Early Treatment Diabetic Retinopathy Study (ETDRS) chart.The systematic literature review identified 22,949 records, of which 23 studies were included in the NMA. At 12 months, the ranibizumab T&E dosing regimen vs ranibizumab pro re nata (PRN) was associated with small differences in change in BCVA, between 1.86 letter gain at 12 months and 2.35 letter gain at 24 months. A similar difference was observed in the aflibercept dosing regimen versus ranibizumab T&E ; 1.94 letter gain at 12 months and 3.31 letter gain at 24 months. All doses of ranibizumab and aflibercept showed similar effectiveness, and the differences between treatment options were not significant.This study used novel repeated-measures NMA to synthesize efficacy results when treatment effects were reported at multiple follow-up times. This repeated-measures NMA suggests that treating patients with the ranibizumab T&E regimen yields similar effectiveness compared to other approved ranibizumab and aflibercept dosing regimens for nAMD treatment.Novartis Pharmaceuticals UK Ltd, Surrey, UK.
Principles and practices of teaching English as an international language

Introduction Aya Matsuda: Teaching English as an International LanguagePart I: Principles in Teaching English as an International Language Chapter 1 Aya Matsuda & Patricia Friedrich: Selecting an instructional variety for an EIL curriculum Chapter 2 Nobuyuki Hino: Endonormative models of EIL for the Expanding Circle Chapter 3 Patricia Friedrich: ELF, intercultural communication, and the strategic aspect of communicative competence Chapter 4 Ryuko Kubota: Toward border-crossing communication in and beyond English Chapter 5 Sandra McKay: Teaching materials for English as an international language Chapter 6 Peter Lowenberg: Assessing proficiency in EIl Chapter 7 Seran Dogancay-Aktuna & Joel Hardman: Teacher education for EIL: Working toward a situated meta-praxisPart II: Showcase of EIL programs, courses, and pedagogical ideas Chapter 8 James D'Angelo: WE-informed EIL curriculum at Chukyo: Towards a functional, educated, multilingual outcome Chapter 9 Farzad Sharifian & Roby Marlina: English as an International Language (International/Intercultural Communication): An innovative program Chapter 10 Hyewon Lee: World Englishes in a high school English class: A case from Japan Chapter 11 Yasemin Bayyurt & Derya Altinmakas: A WE-based English communication skills course at a Turkish university Chapter 12 Nobuyuki Hino: Participating in the community of EIL users through real-time news: Integrated practice in TEIL (IPTEIL)Chapter 13 Aya Matsuda & Chatwara Suwannamai Duran: EIL Activities and tasks for traditional English classroomEpilogue: Cecil Nelson
Low carbon urban morphologies

According to EU studies, managing global warming cost 1% of global GDP every year, while inaction could cost from 5% to 20%. A small part is required to invest in a low-carbon economy and fighting climate change would in return induce cumulative benefits. Commissioner for Climate Action and Energy consider "we should now move to full scale delivery of all actions needed”._x000D_
This global shift is still expected when consistent progress are to be underlined:_x000D_
-increasing ecological awareness, as promoted by the COP21 Declaration._x000D_
-ground actions in European cities (Agenda 21, Climate an energy Plans, green strategies for housing, transport..)._x000D_
-financial means, i.e. €38 billion EU Funds for Low Carbon economy investments 2014-20, two times more compared to 2007-13._x000D_
_x000D_
The paradox lies in those increasing means, and the huge distance remaining to reach global objectives on climate change._x000D_
MOLOC partners propose to focus on the brakes that limit the impact of local policies and actions. Gathering cities involved in energy transition strategies, the project consist in collectively design and test innovative ways of achieving low carbon cities through a three steps program:_x000D_
1-2017/2018: Analysis of the social, cultural, economic and political models, in an holistic approach of sustainable urban development._x000D_
2-2018/2019: Design of local action plans, based on a joint critical assessment and on a crossed learning process._x000D_
3-2019/2020: Action plan’s implementation and monitoring: energy efficiency management system and networks, alternative behaviors, political recommendations._x000D_
_x000D_
Keen at promoting the values of sharing knowledge and practices, MOLOC is supported by the EU network of cities for sustainable energy._x000D_
Inspired by a bottom up approach, the partners will pay attention: to place uses of the city and ways of living at the center of the reflections, to gain appropriation of local stakeholders within the whole process, and to fit the results for scaling-up and wider dissemination.
Lbs  augmented reality assistive system for utilities infrastructure management through galileo and egnos

The LARA system, the main outcome of the project is a mobile device for utility field workers. The hand-held device integrates different technologies such as: positioning and sensors (GNSS), Augmented Reality (AR), GIS, geodatabases, etc. In practise, this device will guide the field workers in underground utilities to ‘see’ what happening underworld, like an “x-ray image” of the underground infrastructure. The system is using AR interfaces to render the complex 3D models of the underground utilities infrastructure such as water, gas, electricity, etc. in an approach that is easily understandable and useful during field work. The 3D information is acquired from 3D GIS geodatabases.