SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Direct laser interference patterning of ophthalmic polymers

The objectives of this project are to structure ophthalmic polymers by using the Direct Laser Interference Patterning (DLIP)
technique, to study the refractive index modification, and to assess the optical and the microstructural properties of laser
structured samples. DLIP technique allows processing large macroscopic areas with controlled periodic micro- and submicrometer
patterns, in a single step and in very short times, usually in less than one second. These characteristics result in
a higher efficient manufacturing process when compared to conventional laser structuring techniques which allows the
structuring process to be easily implemented at industrial level.
To determine the maximal refractive index variation produced in each type of polymer laser parameters such as wavelength,
pulsewidth, intensity and incident angle will be modified. Both periodic line and circular gratings will be inscribed. In addition,
correlation between optical absorption enhancement and refractive index modification will be carried out. Finally, laser
structured polymers will be manufactured at prototype scale to assess and validate the industrial viability and suitability of
this processing technique for ophthalmic applications, specifically in the case of intraocular and contact lenses.
The Fellowship will be carried out at the Technische Universität Dresden (Host Organisation) and VOPTICA (secondment
organisation). The project involves both Academic sector and Industry.
This proposal involves the following subjects: Optical engineering, photonics and lasers; materials engineering; medical
engineering, biomedical engineering and technology; and lasers, ultra-short lasers and laser physics.
Diagnostic prediction of caries risk by saliva marker analysis

The present invention discloses a method for predicting caries risk in a subject and a kit based on said method, characterized in that said method comprises: (a) determining the concentration in saliva from said subject of at least one compound selected from each of salivary components (i) of the immune system, (ii) involved in microbial adhesion to a surface of the buccal cavity; and (iii) involved in metabolism in the buccal cavity or in regulating the pH thereof; (b) comparing a response variable calculated from more than one concentration determined in step (a) with a corresponding reference response variable in a population of subjects without caries or in a population of subjects with caries; and (c) determining caries risk based on the degree of difference in response variable compared in step (b), wherein a greater degree of difference between the response variable of the subject and the corresponding reference response variable in a population of subjects without caries or in a population of subjects with caries, is indicative of higher caries risk in said subject.
Evaluation of Antioxidant Activity of the Extracts from the Aerial parts of Cnidium officinale Makino

In order to obtain basic data for utilization of the aerial parts of Cnidium officinale Makino (APCO), the antioxidant properties of the aerial parts and rhizomes of C. officinale were measured using DPPH and ABTS radicals, and nitrite scavenging assays. The ethyl acetate (EA) fraction prepared from the aerial parts of APCO showed the strongest antioxidant activities, and contained high level of total phenolic compounds (325.81 mgTE/g) and flavonoids (259.16 mgRE/g). The concentrations for 50% reductions () values of the DPPH and ABTS radicals, and nitrite by the EA fraction of APCO were , , and , respectively. APCO exhibited approximately 3-9 times higher antioxidant activity than rhizomes of C. officinale. The antioxidant capacities of APCO were positively correlated with its total phenolic contents. Therefore, it was concluded that the aerial parts of C. officinale can be a useful and cost-effective source of natural antioxidant for food or cosmetics.
Development and Evaluation of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) and Polycaprolactone Microparticles of Nimodipine

Polymeric microparticles containing the calcium channel blocker nimodipine were successfully obtained through simple emulsion/ organic solvent evaporating method. The extended release formulations, composed by the polymers poly(3-hydroxybutyrate-co-3- hydroxyvalerate) (PHBV) and polycaprolactone (PCL), were submitted to characterization through X-ray powder diffraction (XRPD), scanning electron microscopy (SEM), differential scanning calorimetry (DSC), thermogravimetric analysis (TG), Fourier transform infrared analysis (FT-IR) and determination of the mean particle diameter. All formulations obtained revealed an amorphous characteristic, proven through XRPD and DSC results. Besides, no chemical interaction was observed between drug and polymer in polymeric microparticles. PHBV-NMP formulation showed a higher drug entrapment, a larger particle size, a thermal degradation behavior similar to that observed for nimodipine and a longer drug release time, being selected for in vivo evaluation. The PHBV-NMP polymeric microparticles were able to keep the pharmacological antihypertensive effect for a longer period of time, becoming a good alternative to control nimodipine release in hypertension treatment.
Development of High Pressure Research Instrument for Keeping of Deep-Sea Multicellular Organisms

In this article, recompression induced resuscitation and atmospheric pressure acclimation of deep-sea multicellular organisms were investigated. Despite captured deep-sea organisms at depths between 910 m and 1,300 m sustain serious damage on decompression and exposure to high temperature of surface seawater, the organisms recovered by immediate re-compression until 5 MPa within 30 minutes after submersible bring back to mother ship. The re-pressurized deep-sea organisms can acclimatize at atmospheric pressure condition for a few months after slow decompression at a rate of −0.025 MPa/h. Furthermore, negative potential application induced antirust effect of pressure-stat aquarium system, which composed of stainless steel, was also described.
(Homological projective duality)-invariance of the tate, beilinson and riemann conjectures

This project will be carried out at the Warwick Mathematics Institute under the supervision of Prof. John Greenlees; I have worked for the past eight years at MIT and I will move in 2020 to the University of Warwick as an Associate Professor. Three of the most important conjectures in mathematics - the Tate conjecture, the Beilinson conjecture and the generalized Riemann hypothesis - concern the location and order of the zeros/poles of the L-functions associated to algebraic varieties. For example, in the particular case of an elliptic curve, the Beilinson conjecture reduces to the Birch and Swinnerton-Dyer conjecture, and in the particular case of a point, the generalized Riemann hypothesis reduces to the Riemann hypothesis. These are two of the seven Millenium Prize Problems. The first objective of this project is to prove that the conjectures of Tate, Beilinson, and Riemann, are invariant under homological projective duality in the sense of Kuznetsov. The second objective is to combine this invariance result with the different homological projective dualities in the literature in order to obtain not only a proof of the conjectures of Tate and Beilinson in numerous new cases but also an equivalence between the generalized Riemann hypothesis of very different algebraic varieties. These objectives will greatly improve the state-of-the-art of the Tate and Beilinson conjectures and will considerably deepen our understanding of the generalized Riemann hypothesis. In order to achieve them, I will combine Kontsevich's noncommutative viewpoint on algebraic geometry with mathematical tools from several different areas (e.g., algebraic topology, derived categories, algebraic K-theory, etc). This will enhance my creative and innovative potential, will foster my professional maturity and independence, will diversify my technical skills, and also will enable me to receive advanced training. Hence, this project is directly aligned with the MSCA-IF-EF-RI objectives.
Cultural transmission and technological evolution in southernmost africa c. 44 – 12 kcal. bp

CulTech proposes a probabilistic and spatially explicit simulation-based study to test the roles of population fragmentation and coalescence to explain variability in the southern African late Pleistocene lithic record. It focuses on the interval c. 44 – 12 kcal. BP relevant to onset and maturation of the Later Stone Age (LSA). The project asks three key questions: Q1) To what extent is the degree to which southern African late Pleistocene LSA lithic assemblages differ as a function of space and time? Q2) Are these patterns of similarity/dissimilarity consistent with expectations derived from simulated population coalescence and fragmentation scenarios? Q3) How do these patterns change through time across the period c. 44 – 12 kcal. BP? It draws on a multi-variate dataset including radiocarbon dates and lithic technological data to develop a series of simulation and model-based approaches to examine the possible demographic dimensions of late Pleistocene technological variability in southern Africa.

CulTech builds on a growing field of computational modelling and simulation-based approaches applied to studies of prehistoric cultural transmission. Simulation based approaches are efficient and can accommodate several variations in population size, density, structure, rates of interaction and mechanisms of cultural transmission. The project draws its principle datasets from southern Africa’s long history of LSA lithic research to evaluate the degree of fit between patterns in the region’s site spatial distribution, lithic data, and expectations from a series of simulations to generate expected population coalescence/fragmentation patterns and their effects on the lithic data. 

The outcomes of these models will contribute significantly to discussions about cultural transmission and population processes in hunter-gatherer societies. These topics are of relevance not just to southern Africa, but to human evolution and global archaeology in general.
Future of the South African mining industry and the roles of the SAIMM and the Universities

Southern Africa hosts the oldest known mine in the world, the 40 000 year old Ngwenya mine in Swaziland, where haematite was mined, presumably for use as a cosmetic. Due to the lack of documented history of the early stages of mining in the region, we today know only that of which scars or relics are still visible or which is still contained in folklore. It is, however, known that coal was mined by indigenous people in KwaZulu Natal. Mining has always been an integral activity of the region. The discovery of gold and diamonds and the subsequent related industries, supported by coal mining to provide energy and followed by several other mining industries, is well known and documented. The role that mining played in the social and economic development of the country cannot be denied. Mining was pivotal in the political development of the country. Now, in 2011, we have a well developed, mature industry facing serious challenges, and it is perhaps opportune to reflect on the way forward and to examine whether the bright past of the industry is reflected in the future. A number of indicators will be briefly reviewed in this paper, including the need for the products of mining, the availability of resources, the political environment, scientific support to the industry, and the provision of the necessary skills to operate the mines. This will be done from the point of view of an engineer, not a political scientist, economist, or whatever other form of analyst. The Encyclopaedia Britannica defines engineering as ‘The application of science to Future of the South African mining industry and the roles of the SAIMM and the Universities
Comppi

Das Kompi-Projekt ist ein umfassendes Projekt für das Instandhaltungsunternehmen zur Entwicklung familienorientierter Arbeit in Community Services und Immigrantenintegrationsdiensten.
Finite Automata with Multiset Memory: A New Characterization of Chomsky Hierarchy

This paper concerns new characterizations of language classes in the Chomsky hierarchy in terms of a new type of computing device called FAMM Finite Automaton with Multiset Memory in which a multiset of symbol objects is available for the storage of working space. Unlike the stack or the tape for a storage, the multiset might seem to be less powerful in computing task, due to the lack of positional structural information of stored data. We introduce the class of FAMMs of degree d for non-negative integer d in general form, and investigate the computing powers of some subclasses of those FAMMs. We show that the classes of languages accepted by FAMMs of degree 0, by FAMMs of degree 1, by exponentially-bounded FAMMs of degree 2, and by FAMMs of degree 2 are exactly the four classes of languages REG, CF, CS and RE in the Chomsky hierarchy, respectively. Thus, this unified view from multiset-based computing provides new insight into the computational aspects of the Chomsky hierarchy.
People, objects and technologies at the interface – multiscalar interaction networks in the aegean bronze age (3100-1200 bc)

The aim of POTI is to investigate the relationship between people, objects and technologies at the interface of cultural encounters, and their role within multiscalar, diachronic interaction networks that characterise emerging complex social worlds within the Bronze Age Aegean (3100-1200 BC). The geographical setting of Aegean islands, with their connected seascapes and coastlines, offer a valuable arena for assessing the dynamics behind past cultural encounters and interaction networks. The primary training objective is to develop a diachronic approach for investigating material, technological and social interactions across multiple spatial scales. To achieve this, training in the application of broad comparative frameworks from island archaeology and Mediterranean network perspectives is needed to integrate the many interactions that constitute complex societies across multiple geographical and chronological horizons. By reassessing the rich assemblages and connections of the Bronze Age Aegean using this approach, cultural encounter interfaces for material culture change can be identified and characterised. Acquisition of GIS and multivariate statistical skills will enable the spatial and chronological mapping of these interfaces, which, anchored within theoretical frameworks of social vs. insular networks, will shed new light on these key arenas for understanding dynamic processes of social interaction, community participation and identity formation within the Bronze Age Aegean.
COMBINATION THERAPY FOR CANCER

The present invention relates to a combination therapy for the treatment of cancer, particularly to combinations of terpinen-4-ol and at least one additional anti-cancer therapeutic agent. The combination therapy of the present invention shows enhanced anti-cancerous therapeutic effects compared to the effect of each of the components administered alone. In some embodiments, the combination therapy provide for a synergistic anti-cancer effect.
Activation of pi3k signalling in the pathogenesis of vascular anomalies

Vascular anomalies are rare soft tissue tumours and malformations formed by abnormal vascular elements of various types, and mainly affect infants, children and young adults. These lesions are painful, many lead to bleeding, infections, organ dysfunction, and they can damage and metastasise to other tissues. Current treatment strategies are invasive, not fully efficient, and there is a high risk of recurrence. To date no specific targeted therapies have been developed. Most of the studies on vascular anomalies are descriptive and focused on their clinical aspects; at the moment, there is a lack of molecular understanding and pre-clinical studies on the field of vascular anomalies. Thus, identifying the causative molecular alterations of vascular anomalies and understanding their biology will lead to more refined diagnoses and will provide better and more directed therapies. Recent published and unpublished observations from our laboratory show that activation of phosphoinositide 3-kinase (PI3K) signalling pathway drive to the developments of a fraction of vascular anomalies; however, the underlying molecular and cellular mechanisms remain enigmatic. In this proposal we aim to (i) unveil alterations in the PI3K signalling pathway components that are involved in the pathogenesis of vascular anomalies, (ii) understand the role of PI3K pathway activation in the development and maintenance of these lesions, and (iii) explore the potential of repurposing PI3K pathway inhibitors for these conditions. For this, we have set up collaboration with clinicians who will provide a large collection of vascular anomalies from patients. Also, in collaboration with Pharma, we aim to use PI3K inhibitors for these diseases. Importantly, these collaborations will allow us to translate our findings into the clinic for future clinical trials. This project proposal seeks to broad our understanding of PI3K activation in vascular biology and to ultimately improve patients’ quality of life.
Telmax Innovation Voucher — SZU

The subject of the project is to carry out homologation tests for electromagnetic compatibility and suitability in terms of safety of electrical equipment.
BACTERIAL POLYPHENOL OXIDASE FROM BACILLUS FOR USE IN OXIDATION OF COLORED SUBSTANCES

A novel polyphenol oxidase is produced extracellularly by bacteria, particularly from the genus Bacillus. The enzyme is useful for bleaching and oxidizing a variety of substrates.
DISPLAY APPARATUS FOR A FIRST OUT TYPE OF FAULT STATUS ANNUNCIATOR HAVING A SERIES STRING OF INTERLOCK SWITCHES

An annunciator for the status of interlock switches connected into a series circuit for supplying power from a power source to a load, includes a memory recording the status of each switch at a selectable instant. A plurality of display elements are arranged in a pattern corresponding to the pattern of the interlock switch circuit. A manually operable switch allows a user to select for graphically showing with the display either the switch status recorded by the memory or the current status of the switches. The signals controlling the display are conditioned so that the particular display element assigned to the first out switch as recorded in the memory flashes to indicate the switch closest to the power source which was not conducting at the selectable instant.
Loom sley drive - has speed-controlled motor to act on cam shaft to give sley more rapid movement in and out of working position

The drive for the sley in a loom, with toggle levers on the sley and pedestals operated by the eccentric drive action of a cam disc, has a rotary speed controlled motor to power the shaft for the cam disc. The shaft pref. has a higher rotary speed when the sley is moved away from the fabric edge and when it is moved back to the fabric edge between the working positions and a rear position, than when the sley is at rest through the cam drive. ADVANTAGE - The mechanism allows high working speeds to be achieved on large looms, without affecting the time span required for the sley to be at rest
Unified, holistic medical data collection and analysis platform

Due to the new EU Medical Device Regulations, the medical device industry needs to continuously obtain more and more accurate clinical data. However, due to limited resources, high costs and long clinical trial durations this data may not be obtained, resulting in (temporary) removal of proven medical devices from the EU market, while new devices may only be available in the EU with significant delay. Hence, the industry is desperately searching for solutions to accurately document clinical evidence of existing and new treatment options in a time and cost-efficient way. We are Raylytic, a German SME from Leipzig, specialised in clinical trials and radiographic image analysis. Since 3 years we have identified the described new business opportunity and started developing UNITY: a unique medical data collection and analysis platform that integrates traditional data collection (clinical data, patient outcome, lab data) with medical image analysis. Thanks to our advances in computer vision and medical image analysis technology, UNITY will be the next state-of-the-art solution, tapping into the clinical diagnostics, imaging software and pharmaceutical trials markets. The impact of UNITY for our clinical trial clients is a cost reduction of up to 40% for the execution of clinical trials. We have identified a favourable regulatory and reimbursement pathway. With the described project we intend to prepare UNITY for FDA and CE market clearance and subsequent successful market launch by 2022. After the project and upon regulatory approval, we intend to directly follow up and sell UNITY to hospitals as a hardware-vendor independent computer-aided diagnosis solution, as they will be using the platform already in clinical trials. Through this project (estimated ROI of 14.2), the company aims to boost its competitiveness, by increasing its revenues to €3 Million and its team to 25 employees by the first year of commercialization.
El futuro del derecho administrativo en la globalización: entre la americanización y la europeización

La globalización está transformándose en una globalización jurídica y responde fundamentalmente a los parámetros de la americanización administrativa y reguladora. Se expone la evolución del Estado individuo céntrico norteamericano hacia un Estado administrativo y regulador. Se analizan los modelos contrapuestos de seguridad de EE.UU. y Europa. Finalmente, se exponen las dos caras de la globalización como americanización. En primer lugar, el modelo ejemplar de la OMC, en el que EE.UU. se somete a su derecho y a sus resoluciones. En segundo lugar, la tentación de unilateralismo y plenos poderes para el presidente, evadiendo el control judicial, que ha quedado rechazado por la jurisprudencia de la Corte Suprema.
THE SOCIAL ECOLOGY OF PUBLIC SPACE: ACTIVE STREETS AND VIOLENT CRIME IN URBAN NEIGHBORHOODS

Drawing on one element of Jacobs' (1961) discussion of the social control benefits of "eyes on the street," this paper explores the link between the prevalence of active streets and violence in urban neighborhoods. Three distinct data sources from the Project on Human Development in Chicago Neighborhoods are merged to explore the functional form and potential contingency of the active streets-violence relationship: (1) video data capturing the presence of people on neighborhood streets; (2) longitudinal data on adolescents (ages 11 to 16) and their self-reports of witnessing severe violence; and (3) community survey data on neighborhood social organizational characteristics. Results from multilevel models indicate that the proportion of neighborhood streets with adults present exhibits a nonlinear association with exposure to severe violence. At low prevalence, the increasing prevalence of active streets is positively associated with violence exposure. Beyond a threshold, however, increases in the prevalence of active streets serves to reduce the likelihood of violence exposure. The analyses offer no evidence that the curvilinear association between active streets and violence varies by levels of collective efficacy, and only limited evidence that it varies by anonymity. Analyses of data on homicide and violent victimization corroborate these findings.