SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Cyclic arylenevinylene polymers

Research work at the University of Manchester (UNIMAN) has developed an efficient synthetic method to prepare arylenevinylene polymers with control of molecular weight and end-group functionality by the ring-opening metathesis polymerization (ROMP) of strained 1,9-cyclophanedienes.  The CyclAr project will use this methodology to deliver conjugated polymers of novel topologies, including rings, 8-shapes, trefoils and others. Macromolecular rings will be prepared by ring expansion metathesis polymerization (REMP) using a tethered ruthenium carbene complex and more complex topologies from telechelic polymers prepared from a bifunctional ruthenium carbene complex. Electron rich (p-type) and electron poor (n-type) polymer topologies will be prepared from the appropriate functionalised cyclophanedienes and topological heterojunctions examined. These molecules will be screened for their photovoltaic performance as the novel molecular topologies can lead to an enhanced charge separation and fewer loss mechanisms - key factors in achieving higher power conversion efficiency in OPVs. The synthetic methodology to be adopted is novel and application of these topological arylenevinylene polymers as semiconducting materials in device fabrication is unprecedented.

The overall aim of the project is to develop novel topologies for arylenevinylene polymers and to investigate the influence of the molecular shape on the physical, optical and electronic properties.
Assessing the feasibility of mt-011, a first-in-class drug to treat glaucoma and other neurodegenerative diseases via a breakthrough mechanism-of-action

Glaucoma is the world's leading cause of irreverisble blindness, affecting 20 million people in Europe and the US. Known as the Alzheimer’s of the eye, glaucoma is a neurodegenerative disorder that causes deterioration in peripheral vision. Affected patients report ‘seeing through a black tunnel’. Treatments to halt vision loss are available however, they are only applicable for the ‘high tension glaucoma’ subtype. For those diagnosed with ‘normal tension', which comprises over 30% of glaucoma patients, no treatments are available, and vision loss is imminent. New drugs that inhibit VASH, a newly elucidated enzyme that is hyperactivated in many neurogenerative diseases, have potential to address this need. 

We at MT-act are a biotechnological start-up who have identified a family of VASH-inhibiting small molecule drugs. Using an in-house proprietary biochemical assay followed by lead optimization, we have identified MT-011, which inhibits VASH with nanomolar affinity, as our lead candidate. Aside from glaucoma, VASH dysregulation is also implicated in other prominent neurodegenerative diseases such as Alzheimer’s and Parkinson’s. Our assets therefore have an inherently broad applicability. 

We aim to develop MT-011 up to the stage of Phase 1 clinical trials, upon which we aim to commercialize the drug via a licensing deal with a pharmaceutical partner. We will then receive upfront and milestone payments with a estimated total deal size of €40M. We are currently in discussion with world-leading pharmaceutical companies Pfizer and Santen Pharmaceuticals, who have already indicated interest in our drugs.

In SA-VOIR, we aim to strengthen the business case for MT-011 and to outline a detailed technical plan for its continued development. These documents will not only guide us in developing MT-011 towards Phase 1 trials in an effective and de-risked manner, it will also form critical components of a business plan that we will use to attract further investment.
Closing Schemas in Object-Relational Databases

Schema closure is a property that guarantees that no schema component has external references, that is, references to components that are not included in the schema. In the context of object-relational databases, schema closure implies that types, tables and views do not have references to components that are not included in the schema. In order to achieve schema closure, in this work two basic approaches known as enlargement closure and reduction closure are proposed. Enlargement closure includes in the schema every referenced component. Reduction closure, on the other hand, is based on the transformation of the components that have external references, eliminating these references to fulfill schema closure. In this work, both closure approaches and the algorithms to carry out the closure in each of them are described. These algorithms generate and incorporate the needed components, whether being types or views, to reach the schema closure making easier therefore the definition of external schemas. Finally, to illustrate the concepts proposed in this work, we explain how to carry out schema closure in SQL:2008.KeywordsReduction ClosureObject TypeExternal ReferenceSchema ClosureObject ViewThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
‘Development of hypoxia-activated quadruplex dna binders as potential cancer therapeutics’

Cancer is the second leading cause of death globally. In spite of the great advances in cancer therapy over the past two decades, there is still a pressing need to develop new therapies with reduced side effects caused by conventional therapies. Historically, many chemotherapeutic approaches to treat cancer, have targeted DNA. But targeting genomic DNA has some disadvantages such as undesired side effects due to low selectivity of most chemotherapeutics (e.g. cisplatin and alkylating agents). 
In this project I aim to address this problem via the development of ‘smart’ compounds that have the following features: (i) target G-quadruplex DNA structures instead of duplex DNA; this non-canonical DNA topologies form transiently during replication and transcription (as well as in the telomeric region) and have been identified as attractive targets for anticancer drugs (ii) developing compounds that are only activated in tumors and not in healthy tissue to achieve this, I have designed pro-drugs that are only activated in the hypoxic (low levels of oxygen) conditions present in tumors and only when activated can target G-quadruplex DNA (iii) my ‘smart’ compounds will not only target G-quadruplex DNA once activated but will release a second drug able to target other cancer molecular targets (e.g. topoisomerase I, COX-2) to cause a cumulative response of the chemotherapeutic agent. I expect to see significant synergism between the different chemotherapeutics released upon activation of the pro-drug. This synergy in the activities is expected to play an important role to overcome drug resistance. The multidisciplinary nature of the project is strong. The proposal includes both way transfer of knowledge between the host group at Imperial College of London and the candidate in new advanced skill sets and techniques. The proposed work will expand my experience, research competencies, and professional networks, enhancing the development of my career as an independent researcher.
Trajetória da indústria de transformação nos anos 2000 e o papel das políticas públicas no contexto de reindustrialização e seus novos paradigmas tecnológicos

This article aims to identify and evaluate the performance of the manufacturing industry in Brazil in the 2000s, and thus point out public policies that can contribute to the reindustrialization process and its new technological paradigms.For the feasibility of the research, it was adopted as an articulated methodology, both historical, qualitative and quantitative, to generate more robust information.Regarding the collection of quantitative information, the following databases were followed: COMTRADE, IPEA, PIA / IBGE, RAIS / MTE, TIVA / OECD and WDI.Thus, it found: i) growing loss of participation of the manufacturing industry in GDP and in total employment over the last few decades; ii) instabilities in productivity; iii) loss of mark-up in the industry; and iv) deepening of external dependence on technological products.Given this fragile situation of the industry, which causes damage throughout society (such as employment, income, sustainable growth), it is necessary to devise a new developmental project (according to current technological paradigms) with compatible public policies, and aimed at leveraging strategic sectors of the transformation industry, such as the semiconductor segment, in which they are considered strategic for economic development, being a vector of innovations that will be applied in other industries.
A Macroeconomic Structure of Employment: Rural-Urban Conflict in a Kaleckian Framework

Faced with the phenomenon of “jobless growth” and to contain the vast “surplus population” the governments of the developing world have taken up measures to manage poverty and social security outside the sphere of accumulation-led growth in the “urban-modern” sector especially through “rural” employment generation. Many researchers criticize such policies, as government expenditure supporting accumulation and growth of the urban sector is thought to be competitive with government financed rural employment creation. However, my assertion is that there is no demand-driven trade-off between these urban and rural employment generations. In fact, I propose a supply-side trade-off. The generic “food-supply-constraint” creates this rural-urban conflict. To investigate this phenomenon, first a Kaleckian macroeconomic framework is constructed, with which I examine the role of the government and that of the “food sector” in supporting accumulation in the modern sector and thereby generating urban employment. Subsequently, the issue of rural employment creation with the help of food surplus and through direct government intervention is considered. Finally, we arrive at the issue of the rural-urban conflict: the conflict between the effects of government involvement in accumulation-led urban employment generation and of direct government intervention through “development management” administrating rural employment. However, I also propose a policy that could minimize such a contradiction. JEL classifications: O11, O18, O20, Q18
Measurement Method in Model Test of Ice Breaking by Air Cushion Vehicle

A high accuracy non-contact laser displacement measuring system is developed to obtain the surface deformation of the ice-like material. A speed measurement and positioning system is established for the moving air cushion load. The mechanical properties of the ice-like material and the pressure distribution of air cushion load are measured. Under different air cushion load and different speed, a series of experiments of the deformation of ice-like material are carried out in towing channel which the depth of water is variable. The maximum deformation of ice-like material can be caused when air cushion load moves at critical speed, and the ice-water resonance mechanism of ice-breaking by air cushion is revealed, which provides the basis of ice-breaking for practical air cushion vehicle.
Advanced strategies for substitution of critical raw materials in photovoltaics

STARCELL proposes the substitution of CRM’s in thin film PV by the development and demonstration of a cost effective solution based on kesterite CZTS (Cu2ZnSn(S,Se)4) materials. Kesterites are only formed by elements abundant in the earth crust with low toxicity offering a secure supply chain and minimizing recycling costs and risks, and are compatible with massive sustainable deployment of electricity production at TeraWatt levels. Optimisation of the kesterite bulk properties together with redesign and optimization of the device interfaces and the cell architecture will be developed for the achievement of a challenging increase in the device efficiency up to 18% at cell level and targeting 16% efficiency at mini-module level, in line with the efficiency targets established at the SET Plan for 2020. These efficiencies will allow initiating the transfer of kesterite based processes to pre-industrial stages. These innovations will give to STARCELL the opportunity to demonstrate CRM free thin film PV devices with manufacturing costs ≤ 0.30 €/Wp, making first detailed studies on the stability and durability of the kesterite devices under accelerated test analysis conditions and developing suitable recycling processes for efficient re-use of material waste. The project will join for the first time the 3 leading research teams that have achieved the highest efficiencies for kesterite in Europe (EMPA, IMRA and IREC) together with the group of the world record holder David Mitzi (Duke University) and NREL (a reference research centre in renewable energies worldwide) in USA, and AIST (the most renewed Japanese research centre in Energy and Environment) in Japan. These groups have during the last years specialised in different aspects of the solar cell optimisation and build the forefront of kesterite research. The synergies of their joined efforts will allow raising the efficiency of kesterite solar cells and mini-modules to values never attained for this technology.
Translating science in the long italian eighteenth-century. the role of translators and publishers as “cultural mediators” (1760-1790s)

During the second half of eighteenth-century, the Italian peninsula was involved in the so-called “reading revolution”, a process characterized by an important increase of the number and diversification of the interests of the public. Professors, students, members of technical-administrative élites, but also a wider community of readers were significantly interested in Italian and foreign books, such as novels, scientific and technical manuals, travel literature or philosophical and historical works. In particular, scientific publications coming from other European countries significantly attracted the attention of readers having a strong professional interest or a simple curiosity in medical science, agronomy or natural sciences. The largest part of these texts was available to “common” readers – who knew only their own language – mainly through translations, that – as numerous scholars have highlighted – should be conceived not only as linguistic activities, but also as cultural practices. Starting from this final assumption and trying to combine different approaches (cultural history of translations, history of publishing, study of cultural transfers), the project TransIt aims to give a contribution to our understanding of the processes of circulation and reception of scientific ideas in Italy during the Enlightenment, by examining a specific corpus of translations of English and French works, and, especially, the role played by translators and publishers. The study of translations – and of translators’ and publishers’ policies in particular – is an useful tool to investigate the ways in which ideas were re-elaborated and assimilated in new cultural, social and political contexts. Translators and publishers acted as authentic “cultural mediators”, always very attentive to satisfy public’s demands, by adopting different textual and paratextual strategies aimed at adapting the new foreign scientific theories and languages for the new readers’ taste and knowledge.
Hodgkin lymphoma: insights from genomic studies of mutations in coding and non-coding regions

Classical Hodgkin Lymphoma (cHL) is one of the most common cancers in young adults. While chemo-radiotherapy is effective, many patients continue to die of cHL or to suffer long-term treatment toxicities, such that more effective and less toxic drugs are needed. Studying the mechanisms underlying the puzzling biology of cHL (the only B cell-derived lymphoma loosing its B-cell identity) should illuminate its pathogenesis and possibly aid in developing better therapeutic strategies. In this project, I will study the function of mutations in the DNA binding domain of the STAT6 transcription factor, which the host laboratory identified as one of the most frequent genetic lesions in cHL. I will perform genome-wide ChIP- and RNA-seq studies to uncover aberrant gene expression regulation and occupancy by mutant versus wild-type STAT6 in cHL versus non-Hodgkin lymphoma (NHL) cell lines, and investigate their functional consequences at the cellular level. I will then express mutant STAT6 in germinal center (GC) B cells, the cHL cell of origin, to evaluate their role in early lymphomagenesis. Because genes mutated in cHL greatly overlap with those altered in NHLs, from which cHL is strikingly different, I will also explore whether unidentified mutations in non-coding regulatory regions may underlie the peculiar cHL pathogenesis. Recurrent somatic non-coding mutations will be identified through whole-genome sequencing of primary cases and will be annotated to the non-coding elements specifically active in cHL cell lines, which I will identify through RNA- and ChIP-seq for key histone marks. Finally, I will use appropriate techniques (e.g., genome topology and CRISPR editing) to assess how such mutations may alter regulatory networks important for cHL biology and identity. The project will also expand my expertise in genomic regulation in lymphomas, boost my research productivity after a career break, and support my transition to an independent investigator.
A Cost-Efficient LDPC Decoder for DVB-S2 with the Solution to Address Conflict Issue

In this paper, a cost-efficient LDPC decoder for DVB-S2 is presented. Based on the Normalized Min-Sum algorithm and the turbo-decoding message-passing (TDMP) algorithm, a dual line-scan scheduling is proposed to enable hardware reusing. Furthermore, we present the solution to the address conflict issue caused by the characteristic of the parity-check matrix defined by DVB-S2 LDPC codes. Based on SMIC 0.13µm standard CMOS process, the LDPC decoder has an area of 12.51mm2. The required operating frequency to meet the throughput requirement of 135Mbps with maximum iteration number of 30 is 105MHz. Compared with the latest published DVB-S2 LDPC decoder, the proposed decoder reduces area cost by 34%.
Development, operation, and quality assurance of trustworthy smart iot systems

To unleash the full potential of IoT, realizing the digital society and flourishing innovations in application domains such as eHealth, smart city, intelligent transport systems, and smart manufacturing, it is critical to facilitate the creation and operation of trustworthy Smart IoT Systems. Since smart IoT systems typically operate in a changing and often unpredictable environment, the ability of these systems to continuously evolve and adapt to their new environment is decisive to ensure and increase their trustworthiness, quality and user experience. The DevOps movement advocates a set of software engineering best practices and tools, to ensure Quality of Service whilst continuously evolving complex systems and foster agility, rapid innovation cycles, and ease of use . Therefore, DevOps has been widely adopted in the software industry . However, there is no complete DevOps support for trustworthy smart IoT systems today. 
The main technical goal of ENACT is to develop novel IoT platform enablers to: 
i) Enable DevOps in the realm of trustworthy smart IoT systems, and enrich it with novel concepts for end-to-end security and privacy, resilience and robustness strengthening trustworthiness, taking into account the challenges related to “collaborative” actuation and actuation conflicts. 
ii) Facilitate the smooth integration of these to leverage DevOps for existing and new IoT platforms and approaches (e.g., FIWARE, SOFIA, and TelluCloud).

This will be accomplished by evolving current DevOps methods and techniques to support the agile development and operation of smart IoT systems, and provide a set of novel mechanisms to ensure quality assurance and trustworthiness, such as actuation conflict handling, continuous testing and delivery across IoT, edge and cloud spaces and end to end security and privacy management. Through this ENACT will provide a DevOps framework for smart IoT Systems
Investigating DMFT Indicator and its Correlation with the amount of Serum Ferritin and Hemoglobin in Students with Beta- thalassemia Major in Ahvaz, South West of Iran

Background: Thalassemia is the most common single-gene disorder that carries along many difficulties and effects such as oral and dental problems in patients. This study aimed to determine DMFT indicator and its correlation with the amount of serum ferritin and hemoglobin in patients with thalassemia major. Materials and Methods: This cross-sectional study has been conducted by descriptive-analytical method, in 2015 with the participation of 50 patients with thalassemia major referring to Shafa hospital in Ahvaz and 50 healthy samples who were demographically similar to patients. Then, DMFT indicator was investigated in both groups; the amount of hemoglobin and serum ferritin was considered in patients, too. Results: In the patient group, the average of DMFT indicator was 4.94 with a standard deviation of 1.5 and in control group 5.8 with a standard deviation of 2.04 (P<0.05). There was a significant difference between the averages of the filled teeth in two groups (P<0.05); but there was not any significant relationship between the amounts of hemoglobin and serum ferritin on the one hand and DMFT indicator on the other (P< 0.05). Conclusion: Considering that the results showed that thalassemic patients are not in appropriate condition regarding the oral and dental hygiene and dental health and referring to dentist. Educational these patients and their families about the increasing use of dental care and oral hygiene and treatment are recommended.
Integrated technical training and communication activities for the Slovenian operators of the large distribution, the restaurant and agricultural sectors, with regard to fruit-and-vegetable quality production from the Venetian province

The project focuses on communication and promotional activities, aimed at divulging information about the typical and organic Venetian products in the Slovenian area involved in the project. This initiative envisages the organization of promotional events in the Venetian province, through the support provided by local companies which manufacture typical quality and organic produce. In order to foster communication on the two sides of the border, a bilateral Venetian-Slovenian press-office is going to be set up, to disseminate information about the project. In the area of Quarto d’Altino, the nevralgic centre of the economic activities in the province of Venice, technical seminars in the fields of agronomy, commerce, cuisine and tourism will be organized. Hence the improvement and consolidation of the agreements and exchange activities between Italian and Slovenian operators, to develop the mutual penetration between these two areas, spreading knowledge and giving rise to a Slovenian demand for organic produce and typical products from the Venetian province. In Slovenia therefore the consumption level of the products from the Venetian province, that can be identified with specific quality (typical, organic, etc.) certifications, can be increased by improving and intensifying exchanges between Slovenian and Italian operators, creating concrete opportunities of exchange and use of mutual structures and commercial equipment.