SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Metal-Dependent catalysis of nanozymes: first steps towards computational nanoenzymology

The functionalization of monolayer-protected gold nanoparticles is at the frontier of nanotechnology, with innovative applications emerging in fields such as nanomedicine, chemosensing, and catalysis. Here, we focus on nanomaterial-based artificial enzymes called nanozymes, which have been shown to be highly stable and low-cost alternatives to natural enzymes in a wide range of applications. For example, the self-organization of Zn complexes on the surface of gold nanozymes has been shown to generate multiple bimetallic catalytic sites capable of promoting the cleavage of an RNA model substrate. This two-metal-aided mechanism found in nanozymes closely resembles that used by many metalloenzymes that process nucleic acids in cells. However, the complex, hybrid, and flexible nature of the outer coating monolayer of nanozymes has so far made it difficult to investigate the structure and dynamics of these multifunctional chemical systems, which have reached a level of complexity resembling that of proteins. 
Within this context, this project’s ambition is to use classical and hybrid QM/MM simulations coupled to free-energy computation, integrated with experiments, to study the metallo-dependent functionality and mechanisms of nanozymes that cleave nucleic acid model substrates. Through CompNanozymes, the fellow will thus acquire additional expertise in computational simulations, completing his research skill set and allowing him to grow into an independent group leader. Success will also fill the large knowledge gap in our understanding of nanoparticle structure-function relationships in nanozymes, advancing the field of computational nanodesign and directly impacting nanochemistry as a whole.
Evaluating A Communication Technology Assessment Tool (Ctat): A Case Of A Cloud Based Communication Tool

A primary concern of distributed adaptive development environment (DADE) is that of human communication and knowledge sharing among geographically dispersed developers. Emerging cloudbased communication technologies claim to provide a support for communication and knowledge sharing among developers in a DADE. However, the challenge is how to enable developers to self assess and select appropriate cloud-based communication technologies for their DADE. Based on our recent empirical study, we have developed the construct of a practical communication technologies assessment tool (CTAT). We argue that, CTAT construct, as a part of our large conceptual framework of context aware cloud adaptation (CACA), can be useful to assist developers in the self assessment of appropriate cloud-based communication technologies for their DADE. This paper presents the evaluation of the CTAT by using it for the assessment of the Force.com cloud-based Chatter communication tool. The main objective of this evaluation is to determine to what extent CTAT construct is relevant, valuable and sufficient to achieve its purpose. The results of this evaluation indicate that CTAT seems useful when performing vendor independent assessment of communication technologies in order to make an informed decision about the selection of a communication tool for the DADE.
The fate of volatiles in magma on mercury

Mercury has been extensively characterized by the NASA MESSENGER spacecraft that was orbiting the planet from 2011 to 2015. The surface of Mercury is covered by lavas and magmatic processes have structured the planet into an extremely large core, a thin mantle and a relatively thick crust, which is highly reduced, iron-depleted, and rich in volatiles. Some volatiles (sulfur and carbon) have been measured at the surface in relatively high abundances compared to other terrestrial planets butthe speciation, role and their fate under highly reducing conditions are still unclear. In this research program, the understanding of the evolution of volatiles in magma on Mercury will be advanced by combining MESSENGER data and laboratory experiments. Relevant data will be obtained from high-temperature and low- to high-pressure experiments using furnaces, presses and multi-anvil apparatus. We will investigate experimentally compositions corresponding to the possible primitive mantle composition, and to surface compositions provided by X-Ray Spectroscopy data from MESSENGER. These recent data provide a unique opportunity to perform innovative experiments under the extremely reducing conditions characteristic for Mercury on sulfides liquid immiscibility, mantle partial melting, and speciation and solubility of volatiles in magmas. Our objectives are to provide new and firm constraints on (1) the P-T position of the solidus of the mantle of Mercury; (2) the speciation, role and fate of carbon and sulfur volatiles in magmas on Mercury and (3) the partitioning of trace elements between sulphide melts (FeS and (Ca,Mg,Fe)S) and silicate melt in the Mercurian mantle.
The neural dynamics of task context in free recall

Multivariate pattern analysis (MVPA) is a powerful tool for relating theories of cognitive function to the neural dynamics observed while people engage in cognitive tasks. Here, we use the Context Maintenance and Retrieval model of free recall (CMR; Polyn et al., 2009a) to interpret variability in the strength of task-specific patterns of distributed neural activity as participants study and recall lists of words. The CMR model describes how temporal and source-related (here, encoding task) information combine in a contextual representation that is responsible for guiding memory search. Each studied word in the free-recall paradigm is associated with one of two encoding tasks (size and animacy) that have distinct neural representations during encoding. We find evidence for the context retrieval hypothesis central to the CMR model: Task-specific patterns of neural activity are reactivated during memory search, as the participant recalls an item previously associated with a particular task. Furthermore, we find that the fidelity of these task representations during study is related to task-shifting, the serial position of the studied item, and variability in the magnitude of the recency effect across participants. The CMR model suggests that these effects may be related to a central parameter of the model that controls the rate that an internal contextual representation integrates information from the surrounding environment.
Changing Ethics Policies Without Scandal: State Responses to Published Reports and the Importance of Accurate Information

This article details how states responded to the State Integrity Investigation—a large-scale study that sought to rank states based on their risk of corruption. Although some states responded with policy changes, the article demonstrates that responses were not due to how well the states performed compared to other states. Rather, their ranks on the survey magnified the effect of prior information on the state’s ethics policies. Additionally, it goes on to show flaws in the ranking methods used in the State Integrity Investigation and demonstrates that these ranks likely created inconsistent responses from states with regard to changing ethics policies.
Approaches adopted by extension workers for dissemination of improved pulse production technologies in Uttar Pradesh

Uttar Pradesh is one of leading state in relation to area (24.0 lakh ha) and production (21.0 lakh tonnes) of pulses crops. There is wide gap between technology generation, technology dissemination and technology utilization (Farmers) system. Centrally sponsored several specific programmes viz; Technology Mission on Pulses (TMP), National Pulse Development Programme (NPDP), Intensive Scheme of Oilseed Pulses Palmoils and Maize (ISOPOM) were implemented in the states to achieve desire level of production of pulses. National Food Security Mission, Accelerated Pulses Production Programme are also being implemented during XI plan period to meet target production. Extension workers are main players in technology dissemination process as well as large scale application of technology packages of pulses among farming community. Keeping in view the above facts a study was conducted in the Lakhimpur Kheri, Baheraich, Jalaun, Faizabad, Allahabad, Banda and Aligarh districts of Uttar Pradesh among the 70 extension workers to ascertain the methodology used for dissemination of technologies by extension worker, mode of dissemination, opinion of the extension workers about the pulse production and constraints perceived in transfer of pulse production technologies. About 80% extension workers of Aligarh district contacted through farm & home visit to the farmers. 90% and 70% extension workers from Aligarh and Banda districts were conducting meeting for dissemination of knowledge about Pulse Production Technologies. Majority of extension worker were disseminating technologies through progressive farmer all the district. All the extension workers were in the opinion of growing of pulse due to suitability and profitability of pulse crop. Unsatisfactory pay, poor promotion policy, blue bull and lack of field staff were the main constraint in dissemination of technologies in all the districts.
Path-dependent or dynamic? Cantonal integration policies between regional citizenship traditions and right populist party politics

Abstract Immigrant integration policies are commonly assumed to be shaped by traditional understandings of citizenship and belonging. Accordingly, such policy frameworks are considered path-dependent and thus stable over time. The recent surge of radical right anti-immigrant parties in many Western European countries challenges this stability-thesis. Several scholars contend that this change in the party political landscape caused an illiberal turn, resulting in more restrictive integration policies. This paper tests whether integration policies are indeed challenged by radical right parties, or whether they remain path-dependent policy frameworks, using subnational comparative analysis. The results of our cross-sectional regression analysis over twenty six Swiss cantons reveal that cantonal integration policies reflect clear patterns of regional citizenship culture, suggesting that they remain stable policy frameworks. By contrast, the considerable electoral success of the right populist Swiss People's P...
Federation for fire plus

The Fed4FIRE+ project has the objective to run and further improve Fed4FIRE’s “best-in-town” federation of experimentation facilities for the Future Internet Research and Experimentation initiative. Federating a heterogeneous set of facilities covering technologies ranging from wireless, wired, cloud services and open flow, and making them accessible through common frameworks and tools suddenly opens new possibilities, supporting a broad range of experimenter communities covering a wide variety of Internet infrastructures, services and applications.
Fed4FIRE+ will continuously upgrade and improve the facilities and include technical innovations, focused towards increased user satisfaction (user-friendly tools, privacy-oriented data management, testbed SLA and reputation, experiment reproducibility, service-level experiment orchestration, federation ontologies, etc.). It will open this federation to the whole FIRE community and beyond, for experimentation by industry and research organisations, through the organization of Open Calls and Open Access mechanisms
The project will also establish a flexible, demand-driven framework which allows test facilities to join during the course of its lifetime by defining a set of entry requirements for new facilities to join and to comply with the federation.
FIRE Experimental Facilities generate an ever increasing amount of research data that provides the foundation for new knowledge and insight into the behaviour of FI systems. Fed4FIRE+ will participate in the Pilot on Open Research Data in Horizon 2020 to offer open access to its scientific results, to the relevant scientific data and to data generated throughout the project’s lifetime.
Fed4FIRE+ will finally build on the existing community of experimenters, testbeds and tool developers and bring them together regularly (two times a year) in engineering conferences to have maximal interaction between the different stakeholders involved.
Contralateral tactile masking between forearms

Masking effects have been demonstrated in which tactile sensitivity is affected when one touch is close to another on the body surface. Such effects are likely a result of local lateral inhibitory circuits that sharpen the spatial tuning of a given tactile receptor. Mutually inhibitory pathways have also been demonstrated between cortical tactile maps of the two halves of the body. Occasional reports have indicated that touches on one hand or forearm can affect tactile sensitivity at contralateral locations. Here, we measure the spatial tuning and effect of posture on this contralateral masking effect. Tactile sensitivity was measured on one forearm, while vibrotactile masking stimulation was applied to the opposite arm. Results were compared to sensitivity while vibrotactile stimulation was applied to a control site on the right shoulder. Sensitivity on the forearm was reduced by over 3 dB when the arms were touching and by 0.52 dB when they were held parallel. The masking effect depended on the position of the masking stimulus. Its effectiveness fell off by 1 STD when the stimulus was 29 % of arm length from the corresponding contralateral point. This long-range inhibitory effect in the tactile system suggests a surprisingly intimate relationship between the two sides of the body.
Tobacco and alcohol consumption among health sciences students in Cuba and Mexico

INTRODUCTION: Smoking and alcohol use (beyond social norms) by health sciences students are behaviors contradictory to the social function they will perform as health promoters in their eventual professions. OBJECTIVE: Identify prevalence of tobacco and alcohol use in health sciences students in Mexico and Cuba, in order to support educational interventions to promote healthy lifestyles and development of professional competencies to help reduce the harmful impact of these legal drugs in both countries. METHODS: A descriptive cross-sectional study was conducted using quantitative and qualitative techniques. Data were collected from health sciences students on a voluntary basis in both countries using the same anonymous self-administered questionnaire, followed by an in-depth interview. RESULTS: Prevalence of tobacco use was 56.4% among Mexican students and 37% among Cuban. It was higher among men in both cases, but substantial levels were observed in women as well. The majority of both groups were regularly exposed to environmental tobacco smoke. Prevalence of alcohol use was 76.9% in Mexican students, among whom 44.4% were classified as at-risk users. Prevalence of alcohol use in Cuban students was 74.1%, with 3.7% classified as at risk. CONCLUSIONS: The high prevalence of tobacco and alcohol use in these health sciences students is cause for concern, with consequences not only for their individual health, but also for their professional effectiveness in helping reduce these drugs' impact in both countries.
Integrating the territorial dimension for cohesive S3

COHES3ION aims at improving the PERFORMANCE and IMPACT of S3 and linked ERDF OPs, in terms of delivery of innovation by R&I actors by the integration of the territorial dimension into S3 governance and policy mix, contributing additionally to territorial cohesion in terms of Growth and Jobs.

COHES3ION is composed by 8 regions interested on integrating the territorial dimension into S3 governance, displaying different levels of maturity, areas of concern, and solutions, in the S3 GOVERNANCE & POLICY MIX field. The shared common challenge is to align the S3 to all territorial levels with 2 aims:
- SMART PRIORITIES: Identification of complementarities and synergies between the different levels, in terms of priority or niche opportunities, allowing for the farther specialization of specific territories (region, county, city, metropolis level). 
- GOVERNANCE: Coordination of innovation support players promoting the mobilization of stakeholders and delivering innovation support services all along the territory.

Exchange of experience will focus on: 1) Definition and evaluation of S3 considering spatial planning and monitoring tools; 2) Horizontal coordination of innovation support services at different territory levels; 3) Alignment of placed-based S3 from sub-regional levels (province, county, metropolis, city) to regional S3. 

To that end, COHES3ION will achieve the following outputs and results:
- Development of 8 Smart Territorial Maps.
- Identification and exchange of 20 good practices in 3 focus areas.
- Holding of 41 policy learning events with more than 240 stakeholders.
- Engagement of 8 Stakeholders Groups all along the exchange and strategic thinking process leading to the definition and implementation of 8 Regional Action Plans, aiming at the improvement of regional S3 Governance and/or the development of new sub-regional S3.
- Issue of Recommendations for the mainstreaming of the territorial dimension into ERDF OPs, S3 and other regional policies.
Isolation of rare circulating tumor cells

In 2013 I was awarded an ERC consolidator grant to pursue a novel cancer targeting concept using a recombinant malaria protein. As an ERC grantee I verified the malaria protein (rVAR2) binds to this distinct cancer expressed molecule (CSA) in hundreds of cancer cell lines and thousands of tissue biopsies. Our research demonstrate a pivotal role of CSA in cancer cell migration and thus in the formation of metastasis. Circulating tumor cells (CTCs) are cancer cells escaping the primary tumor with the capacity to settle and form a metastasis in distant organs. Isolation of CTC is thus a very attractive non-invasive measure of the stage of a given cancer and provides the opportunity to do direct phenotypic analyses. However CTCs are in most cases very rare (10 cells pr 1ml blood) and does not uniformly distinguish themselves from normal blood cells. Our preliminary data show that rVAR2 very effectively can be used to isolate CTCs from diverse types of cancer with unprecedented specificity and sensitivity. Such a tool could have wide impact for cancer patients because it could sharpen diagnosis, increase prognostic ability, monitor drug efficacy and facilitate molecular characterization of individual cancers with implications for personalized medicine and basic cancer research.  The aim of the ERC PoC project is to A) prepare for establishment of a separate company with a strategic product plan and B) further develop and validate the methodology enabling diagnosis, prognosis and guide treatment.
1 Mb 0.41 µm² 2T-2R Cell Nonvolatile TCAM With Two-Bit Encoding and Clocked Self-Referenced Sensing

This work demonstrates the first fabricated 1 Mb nonvolatile TCAM using 2-transistor/2-resistive-storage (2T-2R) cells to achieve >10× smaller cell size than SRAM-based TCAMs at the same technology node. The test chip was designed and fabricated in IBM 90 nm CMOS technology and mushroom phase-change memory (PCM) technology. The primary challenge for enabling reliable array operation with such aggressive cell is presented, namely, severely degraded sensing margin due to significantly lower ON/OFF ratio of resistive memories (~102 for PCM) than that of traditional MOSFETs (>105 ). To address this challenge, two enabling techniques were developed and implemented in hardware: 1) two-bit encoding and 2) a clocked self-referenced sensing scheme (CSRSS). In addition, the two-bit encoding can also improve algorithmic mapping by effectively compressing TCAM entries. The 1 Mb chip demonstrates reliable low voltage search operation (VDDmin ~750 mV) and a match delay of 1.9 ns under nominal operating conditions.
VALUE ORIENTATIONS of KAZAKHSTAN YOUTH

Since gaining independence Kazakhstan in the youth structure, self-awareness, value orientations, behavioral imperatives and lifestyle took deep, systemic changes, both positive and negative. At the same time there is a significant increase in the scale, severity and significance of the main range of the problems of youth activities. All this is due, including the fact that today's youth of Kazakhstan - a generation that was born and grew up in a period of serious political, social and economic transformations. Accelerating the development of society causes an increase in the role of youth in public life. By engaging in social relationships, youth modifies them and transformed under the influence of conditions improving it. There is also a change in the value of work status of the youth: dominated by pragmatism and the desire for material prosperity, which in turn is in conflict with the realities of youth employment. Hence the focus on part-time business. Also, young people are essential in today's political conflicts, and it is not so much about the structural forms of political participation, but about young people using the format as tool destabilization. Thus, in the value orientations of modern Kazakhstan youth can be identified extremely contradictory manifestations. The availability of traditional values, the family, marriage, respect for elders, before the onset of extreme individualism.
Working capital subsidy for SAPRO SYSTEM.

The project concerns support to the entrepreneur in providing liquidity and support to day-to-day activities due to the financial difficulties that have occurred to the entrepreneur as a result of the COVID-19 outbreak. Financial assistance under scheme SA.57015 (2020/N)
Europe together 

The project aims at putting in place a cooperation between the schools of the border area, through on-line contacts, meetings and common activities involving students and teachers. In order to ensure the participation of all the project partners the existing schools network - www.ragazzidelfiume.it - will be broadened and upgraded, so as to support information exchanges among the students, forum meetings among teachers and the presentation of the activities carried out by the schools. Special emphasis is placed on a comparison of the two school systems, an aspect that is pivotal to teachers exchanges and partly to students exchanges. The meetings are aimed firstly to present the web as an instrument, in order to facilitate its use to exchange information, observations and experiences, and to update teachers so as to ensure the implementation of the activities envisaged. As regards individual schools, activities are envisaged to put in direct contact the students of the two areas. Educational value is believed to be greater with smaller groups of students, in order to ensure that the meetings are not sporadic but represent the basis for a long-lasting work together. Priority is given to expressive activities and environmental research activities, so as to open a direct dialogue between the two areas. The subsequent availability online of individual experiences turns them into a shared heritage and becomes an inspiration for the other schools participating in the project. Other activities consist in the exchange of printed and/or electronic media.