SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Connectivity in the neural control of muscles in stroke patients.

The lack of objective and robust measurements of motor recovery is a general problem in stroke rehabilitation. After the ischemic event, the motor impairment is assessed using clinical scales that provide only a general overview of the patient’s conditions, without detailed information on the activation of the individual muscles and the pathological co-contractions. In recent years, the hypothesis that the coordination of multiple muscles is wired at the neural level in a synergistic way has received strong experimental evidence. Therefore, the possibility to better understand the recruitment of multiple muscles and use this information for the assessment of motor recovery is extremely relevant for stroke rehabilitation. The project NeuralCon aims to investigate the neural mechanisms behind the control of multiple muscles of the lower limb in healthy individuals and its degeneration in acute stroke patients. The project will address the characterization of the neural coupling between muscles using innovative signal processing approaches applied to the high-density surface electromiographic signals during voluntary contractions. From the electromiographic signals, we will extract information regarding the coupling between multiple motor neurons in different motor pools. The final aim will be the development of a new generation of biomarkers based on the concurrent neural activation of several muscles in the lower limb of acute stroke individuals. The project will combine expertise in several fields: neuroscience of human movement, clinical neurophysiology, stochastic signal processing and computational neuroscience. The NeuralCon project will produce substantial progress toward a better understanding of the neural pathways involved in the coordination of voluntary movements and its modifications in cerebrovascular diseases.
Solar prominences: unraveling the ultimate condensation catastrophe

The most spectacular solar eruptions recorded in history - such as the Grand Daddy Prominence eruption on the 4th of June 1946 - invariably involve the violent ejection of a prominence: a giant, cool and dense plasma cloud that formed spontaneously within the million-degree solar corona. The role of the dominant prominence mass in all magnetically mediated coronal mass ejections is poorly understood, and yet a typical prominence easily outweighs our Earth population in mass (and the Earth itself in size). While they pervade the solar corona in all shapes and sizes, surprisingly little is known on their formation and ultimate disappearance. At the advent of two revolutionary space missions to the inner reaches of our heliosphere (Parker Probe and Solar Orbiter), a dedicated effort on ab initio prominence simulations beyond current resolution limits is needed. This must provide conclusive answers to intriguing riddles: How, where and why does the solar corona spontaneously condense to form these gigantic structures? What is the magnetic field topology throughout the prominence body, and how can it support their weight against solar gravity? What causes the fine structure (so-called threads and barbs) throughout the prominence body, and what is the role of the mysterious solar tornadoes often found at their feet? Can we use their natural oscillation frequencies seismologically? Is it feasible to predict their eruption, and can one quantify their role in space weather contexts? Armed with state-of-the-art, grid-adaptive software to efficiently exploit current and next generation supercomputers, we will resolve these mysteries, confront historic and forthcoming observations, and train a new generation of solar physicists. Along the way, we unravel fundamental processes relevant in many astrophysical contexts: how do radiatively driven, thermal instabilities induce catastrophic, non-gravitationally mediated condensations?
Photonic-Assisted neuromorphic computing system

Neuromorphic computing has emerged as a promising approach to mimic the brain by overcoming the limitation of the conventional computers. The current implementation of neuromorphic computing systems (NCSs) has been done in CMOS technology, which comes with area and power-inefficiency. Enormous effort has been devoted to optimize the area and power-efficiency of such NCSs. One of the most promising approaches is the implementation of NCSs using spin-based devices combined with electronics (i.e. spintronics). Although, power-density is improved by spintronics-based NCSs, they are still far from the power-density of the brain that is attributed to the traditional way of changing the state of magnetic moment using a bias current that contributes to 90% of the total power consumed by such NCSs. Given a technique eliminating or decreasing this bias current, the power density of NCSs can be improved by orders of magnitude. 
PHOTON-NeuroCom proposes a novel approach that adds the benefits from photonics to the current spintronics-based NCSs by replacing the large bias current of the state of the art NCSs with a short polarized laser pulse. This will lead to at least two and three orders of magnitude lower energy consumption and higher speed in comparison with the state-of-the-art spintronics-based NCSs. This is a major step towards filling the huge gap between the power density of human brains and computers. The main objectives of this project are to model magnetic-photonic interaction, design and simulate a NCS through extracted model and fabrication of photonic-assisted STNO.
My previous experience with spintronics and mixed signal IC design has put me in a unique position to run such a promising project. On the other hand, I will benefit from a supervision team from host and partner organization with more than 15 years of experience in photonic integrated circuits and IC design. Moreover, the running FET-OPEN project at Aarhus University will speed up my fellowship.
1498-PUB: Metformin Use in Overweight Patients with Type 1 Diabetes from Brazilian Type 1 Diabetes Study Group (BRAZDIAB)

Metformin is an unexpensive and safe drug for treating type 2 diabetes (T2D) that may also have benefits for overweight (OW) patients with type 1 diabetes (T1D) . Objective: To investigate differences between OW adults with T1D that used metformin + insulin vs. those that used only insulin. Methods: This was an observational study evaluating adults (≥18 years old) with body mass index (BMI) ≥ 25kg/m2. BRAZDIAB was a retrospective, observational study with T1D patients conducted in Brazilian cities. Clinical data were compared between patients who used metformin as adjuvant therapy (group 1 - G1) vs. those who did not use it (group 2- G2) . Mann-Whitney, Chi Square and linear regression tests were used for statistical analysis. Results: 6patients were included and 130 (21.5%) used metformin (mean dose: 1258 mg/day) for a mean period of 39.68 ± 38.78 months. Both groups had similar age, T1D duration and insulin U/kg/day (p=0.73; 0.649 and 0.5, respectively) . G1 exhibited higher HbA1c, total cholesterol, triglycerides, BMI and diastolic blood pressure (p=0.03, 0.08, &amp;lt;0.01, &amp;lt;0.and 0,018, respectively) than G2. Metformin use predominated in females (p=0.03) , those with relatives with T2D (p=0.019) , hypertension (p=0.06) and acanthosis nigricans (p=0.047) . G1 had higher frequency of previous infarction (3.17% vs. 0.47%;p=0.03) than G2. A multivariate analysis confirmed an independent association between metformin use and HbA1c (9.17±1.9 vs. 8.64±1.72%; p=0.001) as well as BMI (29.8±3.8 vs. 28,1±3.0kg/m2; p=0.001) . Conclusions: Metformin use was associated to higher BMI, clinical characteristics of T2D and worse glycemic control, but the differences could reflect the cause of prescription rather than the consequences. Disclosure M.Rodacki: None. L.Zajdenverg: None. J.R.Dantas: None. M.E.N.Ramos: None. C.Negrato: None. M.B.Gomes: n/a. Funding CNPQ
PV sector in the European Union countries – Clusters and efficiency

Abstract European Union (EU) due to several challenges that exist nowadays has changed its Energy Policy. In order to fulfill international commitments concerning greenhouse gas emission and to assure safety in supply and stable prices, EU has been a leader in renewable energy. In many EU countries solar energy is a possible and very viable option. Together with wind energy, photovoltaic energy is the new support core of a low carbon EU economy in what concerns electricity production. In this work clusters of countries were generated based on the energy produced by PV systems and the share of energy from PV systems in the total electricity produced by renewable sources. This work also analyzed the production of energy from the photovoltaic sector in EU and compared it with the existing potential for this type of energy. Roughly half of the EU countries are producing energy within the limits of what is expected, considering the irradiation on optimally inclined plane. However some of them could improve the ratio between energy production and installed power. Considering the leader countries in energy production from photovoltaic, Czech Republic and Spain are the countries that exceed what it is expected.
Aurora Kinase B Expression in Breast Carcinoma: Cell Kinetic and Genetic Aspects

Mitotic deregulations may contribute significantly to cell division errors and the development of aggressive tumor cells. The mitotic kinase Aurora B is essential for chromosome segregation. Its gene is located at 17p13 in close proximity to the TP53 gene. Although the frequent alteration of this locus is well known, the information about the AURKB status and protein expression is limited.50 breast carcinoma cases were evaluated for 17p13 status and chromosome 17 ploidy by FISH and for Aurora B protein by immunohistochemistry.Aurora B protein expression showed a strong correlation with cell proliferation (regression coefficient = 0.77). Therefore, the Aurora B/MIB-1 index was used as a measure of expression, which showed a wide range (1-35%, mean 0.32, SD ± 0.28). A gain in the 17p13 chromosome locus could not be shown while a deletion was stated in 10/50 cases including a subset with TP53 and AURKB codeletion in 6/10 cases. The loss of TP53/AURKB loci strongly correlated with aneusomy (p < 0.0001).Elevated Aurora B expression frequently occurs due to an increased cell proliferation rate in breast carcinoma. Codeletion of TP53 and AURKB at 17p13 indicates a concerted mechanism leading to the survival of cell clones with deficient mitotic kinase function which could contribute to the formation of aneuploid cells and an aggressive tumor phenotype.
Influences of Category Structure on Brand Positioning and Choice

Consumers categorize products to facilitate storage and retrieval of product information. Marketers who understand these processes can develop marketing strategies that may improve the likelihood that their brands are chosen. We integrate two areas of categorization research in marketing: 1) the formation of initial category perceptions as a function of learning goal, and 2) the influence of brand positioning strategies of consumers on category structure when a new brand is discrepant. Hypotheses are presented about the effects of initial category structures on the evaluation of subsequently introduced brands, the effects of category structure on choice, and the influence of brand positioning on the updating of category perceptions. Results indicate four contributions. First, learning goal affects not only category
24G: accurate and reliable health genetic tests

The increasingly technology advances in the genetic field and consumer awareness about their health have led to a rising demand for genetic tests during last years. Genetic tests analyse gene variants of the individual genetic code, providing information about their physical characteristics but also about their health.  Although currently the market is offering these genetic tests, most of them are not complete, mainly focused on wellness or entertainment and not as a holistic health point of view.
24Genetics has developed the most complete, accurate and affordable health genetic tests (24G) direct-to consumer (DTC). Our tests will allow to identify the genetic predisposition of an individual for common diseases, carrier status for inherited illness, familial traits and efficacy and adverse reactions to common drugs. This will enables customers to gain insight into their health, take preventative action and make proactive decisions.
24Genetics is an innovative fast growing Spanish company established in 2017 specialised on genetic testing for Health, Wellness and Ancestry roots. With this project 24Genetics aims to deploy new set of health genetic tests covering more than 500 diseases, strongly impact in the clinical care.  The goal is to provide more targeted and personalised medicine.
Currently, we sell in more than 50 countries around the world and we set up sales offices in Spain, USA and Mexico. 24G project will help us to increase our customer base and expand our business in EU and worldwide.
Higher-Loop amplitudes on the sphere: a new approach to the perturbative expansion of quantum field theories

Almost all we know about particle physics and the Standard Model comes
from scattering experiments and our ability to predict them via
scattering amplitudes (these measure probabilities of scattering
processes). To meet the impressive technological advances of particle
colliders like the Large Hadron Collider at CERN, new tools and
concepts have emerged over the last 25 years. More than giving
methods, they have triggered a revolution in our understanding of the
formal microscopic structure of particle physics, a subject people
thought they knew everything about.

My program is based on a set of formulæ due to Cachazo, He & Yuan
(CHY), that challenge the way we think about scattering
amplitudes. They relate to 'twistor' ideas and string theory. The
former aims at manifesting the geometry of field theories, but failed
so far to grasp their quantum-ness. The latter, in spite of its
mathematical beauty, has the drawback of having additional
contributions that are hard to decouple from the field theory
ones. The CHY formulæ retain the advantages of both methods, and lead
to a variety of remarkable expressions for scattering amplitudes in a
increasing number of theories, including gauge, gravity and scalar
theories.

In a crucial work, I showed that these methods actually carry over to
the first quantum correction: this was the first time ever that
twistor methods were shown to work at the quantum level. My project
aims to extend this and reformulate the full pertubative quantum
expansion of field theories in the CHY language. This would be a major
conceptual advance. I explain that to do so will require to understand
a more fundamental object called Null String, whose quantization will
shed light on my 'quantum CHY formalism'. I also propose applications
of the formalism of interest for LHC physic, like a third order
calculation for the 2 to 3 gluon scattering in gauge theory,  that
all other existing methods have failed to determine so far.
Cytochrome P450s in the synthesis of cholesterol and bile acids - from mouse models to human diseases

The present review describes the transgenic mouse models that have been designed to evaluate the functions of the cytochrome P450s involved in cholesterol and bile acid synthesis, as well as their link with disease. The knockout of cholesterogenic Cyp51 is embrionally lethal, with symptoms of Antley-Bixler syndrome occurring in mice, whereas the evidence for this association is conflicting in humans. Disruption of Cyp7a1 from classic bile acid synthesis in mice leads to either increased postnatal death or a milder phenotype with elevated serum cholesterol. The latter is similar to the case in humans, where CYP7A1 mutations associate with high plasma low-density lipoprotein and hepatic cholesterol content, as well as deficient bile acid excretion. Disruption of Cyp8b1 from an alternative bile acid pathway results in the absence of cholic acid and a reduced absorption of dietary lipids; however, the human CYP8B1 polymorphism fails to explain differences in bile acid composition. Unexpectedly, apparently normal Cyp27a1(-/-) mice still synthesize bile acids that originate from the compensatory pathway. In humans, CYP27A1 mutations cause cerebrotendinous xanthomatosis, suggesting that only mice can compensate for the loss of alternative bile acid synthesis. In line with this, Cyp7b1 knockouts are also apparently normal, whereas human CYP7B1 mutations lead to a congenital bile acid synthesis defect in children or spastic paraplegia in adults. Mouse knockouts of the brain-specific Cyp46a1 have reduced brain cholesterol excretion, whereas, in humans, CYP46A1 polymorphisms associate with cognitive impairment. At present, cytochrome P450 family 39 is poorly characterized. Despite important physiological differences between humans and mice, mouse models prove to be an invaluable tool for understanding the multifactorial facets of cholesterol and bile acid-related disorders.
Digiteal: next generation e-invoicing and e-payment platform, one-click and automatic invoice payment anywhere in the sepa zone

The European financial sector has been opened up, creating significant opportunities for innovative consumer and business-oriented financial services that span the European Single Market.  The EU is standardising the banking and payment landscape, in part through its Single Euro Payments Area (SEPA) payment-integration initiative for the simplification of bank transfers denominated in euro and in part with the upcoming PSD2 with payment initiation and account information services.  
 
DigitealTM is the next generation web and mobile electronic invoicing and payment system that enables payment in and between all countries in the SEPA zone. DigitealTM is unique, offering a SEPA-wide domiciliation management platform for end-users. Our clients are B2C European companies that issue high volume of invoices in paper. We offer an intuitive platform to transmit and manage their invoices sent to consumers, and a low-cost payment enabled by SDD. This reduces their operating costs significantly, allowing issuers to gain significant financial savings with minimal implementation costs. Our end users (their customers) will be able to conveniently manage and pay their mandates and invoices for free. 
 
The DigitealTM payment platform provides more consumer control, increasing business competitiveness and financial control - all whilst significantly lowering cost, environmental impact and carbon footprint. Our payment platform enables companies within the European Union to cut their interoperability transaction costs within and across the EU, and gives EU citizens complete control of their SEPA mandates 
 
Our solution delivers on several key European initiatives, helping make the Digital Single Market (DSM) strategy a reality and delivering the EU eGovernment Action Plan. DigitealTM delivers a step-change in business (and European) competitiveness and aims to reduce the huge dependencies on US online payment services.
The work of art in the world: civic agency and public humanities

Celebrating art and interpretation that take on social challenges, Doris Sommer steers the humanities back to engagement with the world. The reformist projects that focus her attention develop momentum and meaning as they circulate through society to inspire faith in the possible. Among the cases that she covers are top-down initiatives of political leaders, such as those launched by Antanas Mockus, former mayor of Bogota, Colombia, and also bottom-up movements like the Theatre of the Oppressed created by the Brazilian director, writer, and educator Augusto Boal. Alleging that we are all cultural agents, Sommer also takes herself to task and creates Pre-Texts, an international arts-literacy project that translates high literary theory through popular creative practices. The Work of Art in the World is informed by many writers and theorists. Foremost among them is the eighteenth-century German poet and philosopher Friedrich Schiller, who remains an eloquent defender of art-making and humanistic interpretation in the construction of political freedom. Schiller's thinking runs throughout Sommer's modern-day call for citizens to collaborate in the endless co-creation of a more just and more beautiful world.
Prototype for an ultra large structure assembly robot

Autonomous assembly of large structures in space is a key challenge to implement future missions that will necessitate structures too large to be self-deployed as a single piece.  The James Webb Space Telescope has reached this limit and the next generation telescope expected by astronomers, like the High Definition Space Telescope, will therefore require new assembly technologies, in particular autonomous robots. The need for large structures in space goes beyond telescopes and concerns also solar arrays for power plant, light sails to reach outermost regions of the solar system or heat shields to land on Mars.
PULSAR objective is to develop and demonstrate key technologies for in-space assembly of the primary mirror of a 12m diameter telescope. Previously developed building blocks, c.f. first call of the SRC Space Robotics Technology, will be integrated and enhanced for this specific mission, but also to serve future multi-mission applications. 
The project focuses on the assembly of a mirror but the developed technology will be applicable to other large structures. Indeed, assembling a mirror requires far more rigor and accuracy than other identified structures. PULSAR is organized in three demonstration tracks to address major challenges of in-space autonomous assembly of telescope: dPAMT, demonstrator of Precise Assembly of Mirror Tiles; dLSAFFE, demonstrator of Large Structure Assembly in Free Floating Environment; dISAS, demonstrator of In-Space Assembly in Simulation.
Although three demonstrators will be developed, the underlying technology will rely on common building blocks whose use and improvement will benefit from the expertise of the PULSAR partners. Building blocks upgrades will then be supplied to their respective maintainers to pursue the standardization of modular and reusable components for space and non-space robotics. PULSAR is responsible of OG5/SIROM, and will contribute to the development of ESROCOS, ERGO, INFUSE and I3DS.
Intramolecular Oxidative Palladium-Catalyzed Amination Involving Double C–H Functionalization of Unactivated Olefins

Intramolecular palladium-catalyzed amination reactions are becoming important tools for the synthesis of various nitrogen-containing­ heterocycles. This account highlights the developments achieved in this field by domino processes in oxidative conditions using unactivated olefins, due to their advantages in terms of step economy and efficiency. These reactions involve the change of oxidation state in the palladium intermediate, requiring the presence of an oxidizing agent to regenerate the catalytic cycle. This kind of additive is essential for the success of the reaction and it can also furnish nucleophilic species that are incorporated into the final product. Reactions can occur at either the intra/intra- or intra/intermolecular level, providing valuable methodologies for the preparation of (poly)heterocyclic scaffolds. Besides, procedures based on the use of strengthened catalytic systems, more recently, disclosed intriguing conditions have enlarged the possibility to modulate the substrate reactivity. Perspectives in this field are directed to the discovery of new reaction conditions, focusing on the employment of oxidatively stable ligands useful for the asymmetric catalysis­. 1 Introduction 2 Carboamination Reactions 2.1 Pd(0)/Pd(II) 2.2 Pd(II)/Pd(IV) 3 Aminooxygenation Reactions 3.1 Pd(0)/Pd(II) 3.2 Pd(II)/Pd(IV) 4 Diamination Reactions 4.1 Pd(0)/Pd(II) 4.2 Pd(II)/Pd(IV) 5 Aminohalogenation Reactions 5.1 Pd(0)/Pd(II) 5.2 Pd(II)/Pd(IV) 6 Conclusions