SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
COMPLEXIDADES DO ESTUDO DO LÍTIO GEOGÊNICO

No Brasil, a existências de duas importantes províncias pegmatíticas localizadas uma na região do Seridó, no nordeste do Brasil e outra mais a sudeste, ao norte do estado de Minas Gerais, limites com o estado da Bahia, apresentam referências da presença de Lítio Geogênico.&#x0D; O Lítio, geogênico, secundário é um elemento químico que ocorre nos reservatórios geoquímicos superficiais, provenientes da ação do intemperismo químico das fases minerais, portadoras deste elemento. O enriquecimento supergênico fornece este elemento para os solos, sedimentos e água, ou seja, para os reservatórios geoquímicos superficiais. O Lítio é um elemento que traz diversos benefícios terapêuticos, entre eles cita-se o tratamento de distúrbios da saúde mental, como na doença afetiva bipolar, na prevenção de alterações do comportamento, podendo ser relacionado em alguma medida, na redução do suicídio e violência.&#x0D; O suicídio é a décima causa de morte em todo o mundo. As taxas de suicídio variam muito de país para país e de regiões dentro de um país. O Brasil possui uma das menores taxas de suicídio mundial, no entanto esses números vêm aumentando em torno de 30%, nas últimas décadas.&#x0D; As relações entre o Lítio e saúde mental podem ser abordadas pela geoquímica médica, que é um novo campo da Geologia, que investiga a distribuição dos materiais geológicos e as possíveis influências sobre a saúde humana. Este artigo apresenta as dificuldades da tentativa de relacionar os constatados teores de Lítio geogênico, existentes no Nordeste do Brasil, com os números das estatísticas de suicídio de levantamentos do sistema de saúde Brasileiro.
Water quality of the Chhoti Gandak River using principal component analysis, Ganga Plain, India

Chhoti Gandak is a meandering river which originates in the terai area of the Ganga Plain and serves as a lifeline for the people of Deoria district, Uttar Pradesh. It travels a distance of about 250 km and drains into Ghaghara near Gothani, Siwan district of Bihar. It has been observed that people of this region suffer from water-borne health problems; therefore water samples were collected to analyse its quality along the entire length of Chhoti Gandak River.The principal components of water quality are controlled by lithology, gentle slope gradient, poor drainage, long residence of water, ion exchange, weathering of minerals, heavy use of fertilizers, and domestic wastes. At some stations water is hard with an excess alkalinity and is not suitable for drinking and irrigation purposes. The variation in the local and regional hydrogeochemical processes distinguished the geogenic sources from the anthropogenic one.
A NOVEL HYDRATED FORM OF ERLOTINIB FREE BASE AND A PROCESS FOR PREPARATION OF ERLOTINIB HYDROCHLORIDE POLYMORPH FORM A SUBSTANTIALLY FREE OF POLYMORPH FORM B

The present invention provides a novel and stable hydrated form of erlotinib free base, and a process for its preparation thereof. The present invention also provides a process for preparation of erlotinib hydrochloride crystalline polymorph A substantially free of polymorph B. The present invention further relates to erlotinib hydrochloride crystalline particles having mean particle size (D50) ranging from about 4 µm to 15 µm and 90 volume-% of the particles (D90) ranging from about 14 µm to 30 µm, to the methods for the manufacture of said crystalline particles, and to pharmaceutical compositions comprising said crystalline particles.
Corotational instability, magnetic resonances and global inertial-acoustic oscillations in magnetized black hole accretion discs

Low-order, non-axisymmetric p-modes (also referred as inertial-acoustic modes) trapped in the inner-most region of hydrodynamic accretion discs around black holes, are plausible candidates for high-frequency quasi-periodic oscillations (QPOs) observed in a number of accreting black-hole systems. These modes are subject to global instabilities due to wave absorption at the corotation resonance (where the wave pattern frequency $\omega/m$ equals the disc rotation rate $\Omega$), when the fluid vortensity, $\zeta=\kappa^2/(2\Omega\Sigma)$ (where $\kappa$ and $\Sigma$ are the radial epicyclic frequency and disc surface density, respectively), has a positive gradient. We investigate the effects of disc magnetic fields on the wave absorption at corotation and the related wave super-reflection of the corotation barrier, and on the overstability of disc p-modes. For discs with a pure toroidal field, the corotation resonance is split into two magnetic resonances, where the wave frequency in the corotating frame of the fluid, $\tomega=\omega-m\Omega$, matches the slow magnetosonic wave frequency. Significant wave energy/angular momentum absorption occurs at both magnetic resonances, but with opposite signs. The combined effect of the two magnetic resonances is to reduce the super-reflection and the growth rate of the overstable p-modes. We show that even a subthermal toroidal field may suppress the overstability of hydrodynamic (B=0) p-modes. For accretion discs with mixed (toroidal and vertical) magnetic fields, two additional Alfven resonances appear, where $\tomega$ matches the local Alfven wave frequency. They further reduce the growth rate of p-modes. Our results suggest that in order for the non-axisymmetric p-modes to be a viable candidate for the observed high-frequency QPOs, the disc magnetic field must be appreciably subthermal, or other mode excitation mechanisms are at work.
Development and clinical validation of multiplex TaqMan® assays for rapid diagnosis of viral gastroenteritis

There is a need to provide rapid, sensitive, and often high throughput detection of pathogens in diagnostic virology. Viral gastroenteritis is a serious health issue often leading to hospitalization in the young, the immunocompromised and the elderly. The common causes of viral gastroenteritis include rotavirus, norovirus (genogroups I and II), astrovirus, and group F adenoviruses (serotypes 40 and 41). This article describes the work-up of two internally controlled multiplex, probe-based PCR assays and reports on the clinical validation over a 3-year period, March 2007 to February 2010. Multiplex assays were developed using a combination of TaqMan™ and minor groove binder (MGB™) hydrolysis probes. The assays were validated using a panel of 137 specimens, previously positive via a nested gel-based assay. The assays had improved sensitivity for adenovirus, rotavirus, and norovirus (97.3% vs. 86.1%, 100% vs. 87.8%, and 95.1% vs. 79.5%, respectively) and also more specific for targets adenovirus, rotavirus, and norovirus (99% vs. 95.2%, 100% vs. 93.6%, and 97.9% vs. 92.3%, respectively). For the specimens tested, both assays had equal sensitivity and specificity for astrovirus (100%). Overall the probe-based assays detected 16 more positive specimens than the nested gel-based assay. Post-introduction to the routine diagnostic service, a total of 9,846 specimens were processed with multiplex 1 and 2 (7,053 pediatric, 2,793 adult) over the 3-year study period. This clinically validated, probe-based multiplex testing algorithm allows highly sensitive and timely diagnosis of the four most prominent causes of viral gastroenteritis.
Natural Computing in Computational Finance - Volume 3

This book consists of eleven chapters each of which was selected following a rigorous, peer-reviewed, selection process. The chapters illustrate the application of a range of cutting-edge natural computing and agent-basedmethodologies in computational finance and economics. While describing cutting edge applications, the chapters are written so that they are accessible to a wide audience. Hence, they should be of interest to academics, students and practitioners in the fields of computational finance and economics. The inspiration for this book was due in part to the success of EvoFIN 2009, the 3rd European Workshop on Evolutionary Computation in Finance and Economics. This book follows on from Natural Computing in Computational Finance Volumes I and II.
Quantifying household social resilience: a place-based approach in a rapidly transforming community

In an era of ecological degradation, global climate change, demographic shifts and increasing intensity and frequency of natural hazards, the Pacific Islands including the State of Hawai‘i face heightened risk. Human and environmental well-being are tightly coupled; thus, science-based solutions must marry place-based, culturally relevant processes that link disaster preparedness, relief and recovery with resilience theories and applications. However, these fields remain mired in epistemological silos, and the operationalization of these theories has been slow, particularly at the community level. This paper explores the challenges of bridging these intersecting fields and the application of theory to practice, through a community-based case study in Hanalei, Hawai‘i. We deployed household surveys, key informant interviews and traditional talk-story sessions to gather baseline information on demographic and socio-ecological transformations, perceptions of risk and preparedness, and coping and adaptive capacity measures. Results showed that residents exhibit medium-to-high coping and adaptive capacities, while visitors present high vulnerability and dependence upon locals. Social resilience metrics highlight differential coping and adaptive capacities among households with varying characteristics (e.g., sex of head of household, longevity of residence and household size) offering risk reduction targets. A gap analysis developed from a qualitative analysis of open-ended survey questions highlights key sectors, areas and populations with perceived gaps in preparedness and resilience, coupled with ideas for solutions centered around local capacity building and improved knowledge and awareness. Community-based assessments underpin the development of long-term disaster resilience planning initiatives and to addressing gaps in vulnerable sectors and populations.
Backpropagation Neural Ensemble for Localizing and Recognizing Non-Standardized Malaysia’s Car Plates

In this paper, we describe a research project that autonomously localizes and recognizes non-standardized Malaysian’s car plates using conventional Backpropagation algorithm (BPP) in combination with Ensemble Neural Network (ENN). We compared the results with the results obtained using simple Feed-Forward Neural Network (FFNN). This research aims to solve four main issues; (1) localization of car plates that has the same colour with the vehicle colour, (2) detection and recognition of car plates with varying sizes, (3) detection and recognition of car plates with different font types, and (4) detection and recognition of non-standardized car plates. The non-standardized Malaysian’s car plates are different from the normal plate as they contain italic characters, a combination of cursive characters, and different font types. The experimental results show that the combination of backpropagation and ENN can be effectively used to solve these four issues. The combination of BPP and ENN’s algorithm achieved a localization rate of 98% and a 97% in recognition rate. On the other hand, the combination of backpropagation and simple FFNN recorded a 96% recognition rate.
New petrified forest in Maranhão, Permian (Cisuralian) of the Parnaíba Basin, Brazil

Abstract This work presents a new fossil plant-bearing area located in the municipalities of Duque Bacelar and Coelho Neto, Maranhao State, Brazil, recovered from lower Permian (Cisuralian) strata of the Pedra de Fogo Formation, northeastern portion of the Parnaiba Basin. The area comprises more than five exposures with assemblages formed mostly of large gymnosperm woods, a number of them in life-position (reaching up to ∼2.30 m in height and 1.15 m in diameter) and, in lesser degree, of horizontal tree-fern stems (up to 5 m in length), some of them being referable to Psaronius sp. The fossils are recorded in sedimentary beds of continental origin that accumulated in shallow, nearshore areas of large lakes, which eventually were affected by rapid burial episodes generated by non-channelized, high energy fluvial systems. The new fossil assemblages are included within lacustrine rocks placed at the base of the Pedra de Fogo Formation, i.e., Silex Basal Member, near the contact with the underlying Piaui Formation (Pennsylvanian). This observation contrasts with previous studies at the southwestern portion of the basin, where the stratigraphic position of plant fossils is referred to the upper Pedra de Fogo Formation (Trisidela Member) or even to the overlying Motuca Formation. The new sites currently suffer damage from human activities and require urgent actions in order to protect them. Based on the current laws, some measures of protection for these sites are discussed and proposed herein.
Intersections

This edition of European Researcher's Night, run independently of all other NIGHTs, will provide a platform from which researchers and publics across Europe can participate to create a truly pan-national series of events showcasing the international and intersectional nature of research as well as the relevance of, and contribution to research that the public can make.  INTERSECTIONS is developed from past success in international delivery of a group of seven NIGHTs across Europe. This experience has shown international delivery can be meaningful and rewarding, and demonstrated the barriers and drivers to a successful international and intersectional delivery. We propose now to expand on this and provide dedicated support for a pan-European delivery.  In 2021 INTERSECTIONS will run a modest group of activities that we are confident are able to run on an international basis with significant impact and meaningful outcomes for all stakeholders from researchers to audiences. This truly pan-European research showcase event, connecting researchers, audiences, and NIGHTs, will showcase research and its relevance to all European citizens.
Combine ladder with breakaway pivot.

The disclosure relates to a combine ladder (25) with breakaway pivot (32) for an agricultural machine such as a combine (1). The ladder mounting structure comprises a pivot (30) with a transport pivot (31) and a ladder pivot (32). The transport pivot rotates about to the frame (21) and the ladder pivot rotates about the ladder head (26). A breakaway mechanism controls a detent plate (40) affixed to the ladder head (26). The breakaway mechanism comprises a breakaway housing (50) with a rod (51) biased by a spring (52). When the operator manipulates a handle (60), a hub (54) separates from a notch (41) in the detent plate (40). Likewise if a force (78) contacts the ladder (25), the spring (52) allows the hub to move from the notch (41). This permits the ladder (25) to rotate about the ladder pivot (32). If the operator manipulates the handle (60) in the opposite direction, a bolt (36) is removed from the transport plate (35) allowing the ladder to rotate about the transport pivot (31) to the transport position. <IMAGE>
Pyoderma gangrenosum and Sweet syndrome: the prototypic neutrophilic dermatoses

Pyoderma gangrenosum, a dramatic ulcerative skin disease, and Sweet syndrome, a papular dermatosis, were described independently. It was subsequently shown that they share many characteristics, including clinical overlap and the frequent association with multisystemic disorders. The group of the neutrophilic dermatoses encompasses these two dermatoses, as well as other conditions having in common an aseptic neutrophilic infiltrate predominating in the epidermis and/or the dermis and/or the subcutis. Some patients also experience neutrophilic infiltrates in other organs, defining the neutrophilic disease. Recent research suggests that the neutrophilic dermatoses could be considered as the cutaneous expression of the autoinflammation, an aberrant hyperproduction of interleukin-1. Autoinflammation is responsible for monogenic diseases, and is also involved in the mechanism of many polygenic conditions, including the neutrophilic dermatoses.
Explicit Direct Integrators of RK Type for Solving Special Fifth-Order Ordinary Differential Equations

The main contribution of this paper is the development of direct explicit methods of Runge-Kutta (RK) type for solving special fifth-Order Ordinary Differential Equations (ODEs). For this purpose, we have generalized RKD and RKT methods of special third and fourth-order ODEs. Using Taylor expansion, we have derived the algebraic equations of algebraic equations of order conditions for the proposed RKM integrators up to the eighth order. Based on these conditions, two RKM methods of orders five and six with three and four-stage are derived. Numerical implementation shows that the new methods agree well with existing RK methods, but requires less function evaluations. This is so due to the fact that RKM methods are direct; hence, they save considerable amount of computational time.
Getting new insights into the radio-sensitization effects of nanoparticles in photon and charged particle therapy

The use of high-atomic-number nanoparticles (NP) as tumour radio-sensitizers has been recently proposed as a breakthrough in radiotherapy (RT). Numerous biological studies have shown the enhanced effectiveness in tumor cell killing when NP were associated to photon RT and, more recently, to charged particle therapy. However, the mechanisms of action are not clear yet. In addition to the damage due to a possible local dose enhancement (physical effects), the interaction of NP with essential biological macromolecules could lead to changes in the cells (biochemical effects) leading to an amplified effect of the radiation. Within this framework, the main goal of the NANOCANCER project is to get deeper insights into the mechanisms underlying the amplification of radiation effects of NP. For this purpose, I will use a multidisciplinary strategy to evaluate both the biochemical and physical effects involved in these innovative nano-RT approaches. Vibrational spectroscopy (Fourier transform infrared, FTIR, microspectroscopy) will be employed for the first time to investigate the biochemical features in glioma cells combining two high-Z standard nanoparticles (Au and Gd) and charged particle beams. Physical effects will be also assessed by performing complementary Monte Carlo simulation of radiation transport, which will allow a realistic modelling of early biological damages induced by the radiation at the nanometre scale. This interdisciplinary proposal will be essential to better characterize the radio-sensitization effects of NP in glioma cells and, in addition, will bring light to the present charged particle therapy radiobiology, which seems to lead to substantially different tumour responses with respect to conventional RT at the cellular and molecular level. The knowledge of these biochemical features will help researchers to develop RT by taking full advantage of the underlying biology an enhance the therapeutic index of RT for diseases with poor prognosis.
Solutions of the sDiff(2)Toda equation with SU (2) symmetry

We present the general solution to the Plebanski equation for an H-space that admits Killing vectors for an entire SU(2) of symmetries, which is therefore also the general solution of the sDiff(2)Toda equation that allows these symmetries. Desiring these solutions as a bridge toward the future for yet more general solutions of the sDiff(2)Toda equation, we generalize the earlier work of Olivier, on the Atiyah-Hitchin metric, and re-formulate work of Babich and Korotkin, and Tod, on the Bianchi IX approach to a metric with an SU(2) of symmetries. We also give careful delineations of the conformal transformations required to ensure that a metric of Bianchi IX type has zero Ricci tensor, so that it is a self-dual, vacuum solution of the complex-valued version of Einstein's equations, as appropriate for the original Plebanski equation.
Hybrid electric small commuter aircraft conceptual design

This thematic topic focuses on the design of a 19 passenger commuter aircraft based on alternative propulsion concepts (hybrid/electric) targeting near-zero CO2 emissions. A full design loop is required, evaluating a range of design options, resulting in a mature conceptual design for the selected design. The design should be compliant with the new level 4 FAR23 / CS23 regulation. HECARRUS employs methods suitable for analyzing advanced technologies implemented for propulsion and power generation, and takes full advantage of the latest advances in aerospace, electrification and autonomous technologies in a hybrid-electric propulsion strategy to couple the most efficient turbines with generators providing electric power and recharging batteries in several competent technologies, to cover a broad spectrum of these applications. The ultimate idea of the project will be to design a hybrid-electric system with a power output in the range of 1 MW utilizing two engines (two thermal cores) as the propulsive units of a 19-passenger short haul aircraft. With a focus on the key propulsion sub-systems, aircraft structure and performance that interfaces with existing conceptual design frameworks, this project will aim at full design space exploration of the various hybrid-electric concepts at low TRL level. It is underlined that the technologies described and investigated in view of this proposal are complementary to engine core technologies currently under investigation in other EU projects. In other words, the potential fuel efficiency benefits from HECARRUS can be stackedup to efficiency benefits from other projects as all the technologies gradually mature for entry into service by 2030.
Real-Time adaptive particle therapy of cancer

The Real-time Adaptive Particle Therapy Of CanceR (RAPTOR) consortium comprises world-class research institutes, non-academic particle therapy (PT) centres and industrial providers of PT equipment, offering a platform for intercultural, interdisciplinary and intersectoral training of early stage researchers (ESRs) in the field of medical physics with a focus on real-time adaptive PT. This comprehensive expertise and infrastructure is required to address and solve challenges in the clinical implementation of real-time adaptive PT.
PT is an advanced type of radiotherapy used to treat a constantly rising number of cancer patients. PT allows to target tumour with a high accuracy while sparing healthy surrounding tissue from dose. However, changes in anatomy or positioning and organ motion give rise to uncertainties which need to be further minimized to exploit the full benefits of PT. Adapting PT plans in real time has the potential to provide truly personalized treatments, allowing for better target control and less toxicity. A move towards wide clinical implementation of adaptive PT approaches is currently prohibited by (i) stepwise treatment workflows that are time-consuming and largely manual, (ii) the inflexibility of commercial PT equipment, and (iii) the wide range of PT equipment and protocols.
RAPTOR ESRs will conduct research projects at both academic and non-academic health care facilities which will sharpen their focus on clinical needs with respect to real-time adaptive PT. The active involvement of industry ensures that the transfer of industry-relevant skills is an integral part of individual ESR projects. This will guarantee rapid translation of clinical needs into innovative and marketable solutions.
RAPTOR aims to train a new generation of researchers, enabling a paradigm shift from treatment approaches that are manual and stepwise to those that are automatic and seamless, while assuring standardized clinical implementation of real-time adaptive PT.
BIG BUILDING INNOVATIVE GOVERNANCE

INNOVATIVE INTEGRATED SERVICES OF A TECHNICAL AND SCIENTIFIC NATURE AND HIGH TECHNOLOGICAL VALUE FOR THE GOVERNANCE OF REAL ESTATE ASSETS