SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Earth-Abundant metals with exclusively achiral ligands for sustainable chiral-at-metal catalysis

Asymmetric catalysis relies on the design of chiral catalysts and is dedicated to the economical generation of non-racemic chiral compounds, which are building blocks for the production of drugs, agricultural chemicals, flavors, fragrances, and materials. Chiral transition metal complexes constitute an important class of chiral catalysts and are typically synthesized by combining metal salts or organometallic precursors with chiral ligands. A neglected approach follows a different direction and exploits the generation of metal-centered chirality in the course of the assembly of achiral ligands around a central metal. Our group has pioneered the general use of such chiral-at-metal catalysts from noble metals, with the metal center both serving as the exclusive stereogenic center and at the same time acting as the reactive center for catalysis. The design of reactive chiral-at-metal catalysts based on earth-abundant metals, which have economical and environmental benefits, is the focus of this proposal. The design strategy appeals for its combination of sustainability (earth-abundant metals) and simplicity (achiral ligands). Furthermore, without the requirement for chiral motifs in the ligand sphere, untapped opportunities emerge for the design of chiral 3d metal complexes with distinct electronic properties and unique architectures. This unexplored chemical space for chiral catalysts will be applied to the challenging enantioselective functionalization of C(sp3)-H bonds with inexpensive and sustainable 3d metal catalysts.
The implementation of chiral-at-metal catalysts from earth-abundant metals will rely on taming the high lability of coordinative bonds of 3d metals to warrant a satisfactory configuration stability. This will be addressed by exploiting the chelate effect of tailored multidentate ligands in combination with strong-field ligands and attractive weak interactions between coordinated ligands.
I thinkICAN: modulation of TRPM4 channels may contribute not only to the emergence of rhythm, but robust output and metabolic sensitivity of the preBötzinger Complex inspiratory network

Understanding the mechanisms by which central rhythm generators (CRGs) produce the neural rhythms that drive behaviours such as locomotion, chewing and breathing is a longstanding, fundamental problem that also has great clinical relevance. A topic of current debate is whether the basis of CRG function resides in the intrinsic auto-rhythmic properties of pacemaker neurons or emergent properties of the network (Del Negro & Hayes, 2008). Strong support for the latter comes from work in the preBotzinger complex (preBotC, a region critical for rhythm generation) of the inspiratory network that shows powerful functional links among AMPA receptors, Ca2+ channels, group I metabotropic glutamate receptors (mGluRs) and the TRPM4-mediated (transient receptor potential melastatin 4 subtype), burst-generating, non-specific cation current, ICAN (Mironov 2008; Pace & Del Negro, 2008). In this model, referred to as the group pacemaker hypothesis, synaptically released glutamate periodically activates AMPA and group I mGluRs. AMPA receptor-mediated depolarization evokes Ca2+ current via voltage-gated Ca2+ channels. Inositol 1,4,5-trisphosphate (IP3) receptors bind this Ca2+ as well as IP3 synthesized as a result of mGluR activation to cause regenerative intracellular Ca2+ release. Ca2+ from Ca2+ channels and intracellular stores evokes ICAN, which provides the bulk of the inward current underlying the inspiratory drive potential. Thus, the mechanism of rhythm generation in vitro emerges from the properties of a network in which latent burst-generating, intrinsic conductances are recruited by excitatory synaptic interactions among preBotC inspiratory neurons (Feldman & Del Negro, 2006; Pace & Del Negro, 2008).
Apoio às pequenas empresas com um volume de negócios superior a 500 000 BGN para superar o impacto económico da pandemia de COVID-19

Apoio às pequenas empresas com um volume de negócios superior a 500 000 BGN para superar o impacto económico da pandemia de COVID-19
BALL VALVE FOR AIRCRAFT TANK

A drain ball valve (10) for an aircraft tank. Particular embodiments find use in connection with aircraft waste tanks. The drain ball valve has an upper shell (14) that is shaped to be received within a tank drain plumbing line (26). The drain ball valve has a lower shell (30) shaped to receive a funnel (44) and/or a bellow component (50) in order to help direct waste or other fluids exiting the tank.
TRANSFER APPARATUS AND CORRESPONDING TRANSFER METHOD

Apparatus to transfer bottles (11) in a container (12a, 12b), said apparatus comprising at least a transfer device (13) to transfer the bottles (11) in a first direction (D) and a pick-up and delivery member (14) configured to transfer the bottles (11) from the transfer device (13) to the container (12a, 12b). The transfer device (13) and the pick-up and delivery member (14) are disposed consecutive with respect to each other and are of the metering screw type. The pick-up and delivery member (14) is associated to movement means (20) provided to translate the pick-up and delivery member (14) and bring it from a first pick-up condition to a second delivery condition, and vice versa, in a second direction (T), transverse to the first direction (D).
Effects of Concurrent Earthquake and Temperature Loadings on Cable-Stayed Bridges

This paper discusses the necessity of considering the concurrent effects of uniform temperature and earthquake loadings in the design of cable-stayed bridges. This load combination is not foreseen in current design standards such as AASHTO and Eurocode. Three-dimensional finite element models of cable-stayed bridges are employed for nonlinear time history analyses. A load combination is proposed that adds uniform temperature loading to the existing extreme event load combination. The proposed combination is compared with existing extreme event load combination and the changes in forces and displacements are noted. A parametric study is then conducted by varying a number of properties of the cable-stayed bridges such as, span length, shape of the pylon, the deck/pylon connection and the actual temperature load. Pylon reactions and the deck axial forces are found to be more vulnerable to concurrent loadings for cable-stayed bridges of longer spans.
Euro-Mediterranean Network Facilitating Market Uptake of Innovations from SMEs

EMPHASIS is set on co-creating a Mediterranean Open Innovation (OI) ecosystem, in which knowledge flows across borders and is translated into marketable innovations. The project will co-design, deploy and validate a Mediterranean OI service platform, aiming at better linking the fragmented innovation systems of the region by facilitating meaningful cross-border knowledge flows, empower SMEs with the skill-sets required to tap into external knowledge base and turn it into value and identify fields that can turn sustainability challenges (e.g., agri-food, energy, materials) into business opportunities. EMPHASIS will lead to the uptake of the results from a series of projects to identify SMEs, assess their ‘readiness’ to engage with OI and provide them advisory services - in the form of vouchers – to enhance their innovation capacity to build partnerships, covering the different stages of their innovation journeys. A joint transnational approach will be a solid action to address the sustainability agendas through effective market uptake of research outputs.
Open philology: the composition of buddhist scriptures

Buddhist sūtras are fundamental sources for understanding the beliefs that once dominated, and largely continue to dominate, Asian societies. But classical philological approaches to these texts, assuming an Ur-text and linear development, misrepresent their nature and obscure their history. Like oral literature the sūtras are authorless and textually fluid, their content formulaic and modular, and the situation complicated by their huge volume and the linguistic diversity of their extant versions. Their fluidity and the absence of an Ur-text makes traditional stemmatic editing inappropriate. Other options are also unacceptable: eclectic editions conflate distinct sources, creating texts which never existed historically, while exclusive focus on a single version ignores the tradition’s true richness. 
Utilizing the tools of Digital Humanities, Open Philology offers a revolution in approaching the composition of these scriptures, and other literatures with common features, such as the Homeric corpus or Rabbinic literature. Given the vastness of the Buddhist canons, we will focus on a traditional subset of texts, and produce electronic editions which preserve their diachronic and synchronic fluidity, revealing the intertextuality inherent in their formulaic composition. Our editing environments will allow one to easily view the diversity of sources, in different versions of ‘the same text’ and in parallels in other texts, and permit one to view data at any level of granularity, according to one’s interests. 
The project will produce corpora of sūtras mutually aligned in their Chinese, Tibetan and, when available, Sanskrit versions, a map of formulaic content, annotated text editions and translations, a general study of the corpus, and a series of scholarly publications on methodological and content-oriented issues. The tools and results we produce will bring our historical understanding of Buddhism, the most formative influence on Asian cultures, to a new level.
TISSUE PAPER ASSEMBLY

A paper assembly (10) for use as disposable cleaning tissue comprises a first paper member (12) and a second paper member (14), the first paper member (12) having a lower basis weight and a higher water absorbency than the second paper member (14).
Exploring the human gut microbiome at strain resolution

With the genome sequencing of hundreds of bacterial isolates per day and a vast and growing number of metagenomic sequencing projects on gut microbiomes in healthy and diseased people all over the world, it becomes feasible to explore the microbial diversity in us not only at the level of genera and species, but at strains. As two different strains of a prokaryotic species might only share 40% of the genes and can also have vastly differ in single nucleotide polymorphism (SNP) many aspects of a proper understanding of the microbial communities we host in the gut might only be revealed at this high resolution level. This proposal aims (i) to develop a robust methodology to characterize the SNP and gene content landscape from metagenomic shotgun data (ii) to explore patterns of variation in the human population to stratify geographically, but also in subpopulations such as families and to understand spreading patterns and the evolution of microbial strains as well as iii) to work towards medical applications, for example by monitoring fecal microbiota transplantation (FMT) at strain resolution or monitoring particular strain of interest in the population
ARRANGEMENT AND METHOD FOR A MOBILE ACCESS NETWORK

A server (110) with an interface to an user (120) of communications devices (135) arranged to connect to a mobile access network (130). The server (110) is arranged to receive, from said user (120), a request for an IP address for a communications device (135), the request comprising an ID for said communications device. The server checks if the communications device (135) has an IP address in the mobile access network (130), and if this is so, sends the IP address to the user (120), and if not, sends a trigger request to the mobile access network (130) to trigger the communications device (135) to establish an IP connection including an IP address. The server (110) sends the trigger request with a unique identity for the communications device (135), and receives the IP address from the mobile access network (130) and sends it to the user (120).
Higher-Order interactions and laplacian dynamics in complex networks: structure, dynamics and control

Complex networks are an essential ingredient of modern life, and underpin integral parts of our biological, physical, technological and socio-economic universe. Thus far, such networks have been mainly represented as graphs. However, while graphs can capture pairwise interactions between nodes, fundamental interactions in networks often take place between multiple nodes. For example, in socio-economic networks, the joint coordinated activity of several agents (e.g. buyer, seller, broker); the formation and interactions of coalitions; the emergence of peer pressure; and the existence of triadic closure are all prevalent.

The objective of this interdisciplinary project is to investigate such non-binary interactions in complex networks and their dynamical implications. Specifically, we will investigate how such interactions can be taken into account for the modelling, analysis and design of complex networks.

To achieve this, we will extend the geometrical framework of simplicial complexes to account systematically for weighted non-binary couplings of nodes, node-pairs, triplets, etc., allowing us to consistently assess and design higher-order interactions. Here, we will focus on consensus and random walks as prototypical examples of a range of other phenomena. Working at the interface of Network Science and Control Theory, we will combine recent tools from both fields and apply our results to real biological and socio-economic networks and data. We will investigate how the consideration of non-binary couplings can yield an improved understanding of the propagation of external shocks in socio-economic networks, and help to reveal dynamical groupings in networks emerging from systems biology experiments.

Providing a synergy between the applicant’s multidisciplinary background and the leading Systems, Optimization and Control research of the hosts, this proposal holds the potential to leverage the candidate’s career and yield scientific results of general relevance.
Establishment of the first coworking factory in Slovenia — cooperation and coexistence

2.3. The objectives of the call for tenders for the selection of operations are, in particular, to: — encouraging the emergence of new social enterprises, and youth cooperatives with a view to achieving innovative social entrepreneurial ideas on the market;- encouraging existing social enterprises to create innovative enterprises and innovative products and services for sustainable market survival,- job creation and employment in the field of social entrepreneurship;  — increasing the number of social enterprises with a view to developing new innovative business models that enable social needs to be met and societal impacts to be achieved and their sustainable functioning increased;  — increasing the social inclusion of vulnerable groups in particular by promoting their activation and the realisation of their entrepreneurial ideas on the market; reducing the development gap by strengthening the social economy ecosystem.
Improved Environment and Resource Efficiency through use of Life Cycle Instruments for implementation of regional policies of the European Union

LCA4Regions is expected to contribute to a more effective implementation of environmental policy instruments by the application of Life Cycle Methodologies. Currently many individual policies are implemented in isolation of others. Thus, the project is focused on expanding the use of life cycle methods as a holistic approach when conceiving and implementing public policies related to the environment protection and resource efficiency.

Life cycle expertise resides mainly in the business sector while public authorities are much less familiar with the techniques and their functioning. However, the full success of policy implementation depends on a similar expertise also in governmental authorities. The outcomes of improved public policy implementation are greater concordance with stated sustainability objectives, fewer unwanted side-effects and greater transparency in the compromises and offsets that need to be made to move ahead on sustainable economic targets.

Each project region has its own characteristics, methods of design and implementation of policies. Nevertheless, all of them face a common challenge: the adoption of a more efficient use of natural resources to reduce the non-desirable secondary effects (spill-overs) that generate negative economic and environmental impacts.

Expected result: 7 Actions Plans to improve 7 policy instruments funded by the ERDF. This is achieved through, inter alia, intense local stakeholder group involvement, 7 transnational learning journeys, exchanges of experiences, study cases and the compilation of good practices. These activities are intended to clarify the success factors and barriers for the application of life-cycle management approaches for policy implementation. 
Action plans will contribute to 1) improve policy instruments introducing the LCA in all steps of policy cycle management 2) Enlarge the circle of end-users that will benefit from making conscious decisions on resource efficiency and investments using the LCA
Power of algorithms in discrete optimisation

Convex relaxations, such as linear and semidefinite programming, constitute one of the most powerful techniques for designing efficient algorithms, and have been studied in theoretical computer science, operational research, and applied
mathematics. We seek to establish the power convex relaxations through the lens of, and with the extensions of methods designed for, Constraint Satisfaction Problems (CSPs).

Our goal is twofold. First, to provide precise characterisations of the applicability of convex relaxations such as which problems can be solved by linear programming relaxations. Secondly, to derive computational complexity consequences such as for which classes of problems the considered algorithms are optimal in that they solve optimally everything that can be solved in polynomial time. For optimisation problems, we aim to characterise the limits of linear and semidefinite programming relaxations for exact, approximate, and robust solvability. For decision problems, we aim to characterise the limits of local consistency methods, one of the fundamental techniques in artificial intelligence, which strongly relates to linear programming relaxations.

Recent years have seen some remarkable progress on characterising the power of algorithms for a very important type of problems known as non-uniform constraint satisfaction problems and their optimisation variants. The ultimate goal of this
project is to develop new techniques and establish novel results on the limits of convex relaxations and local consistency methods in a general setting going beyond the realm of non-uniform CSPs.
Locking system and components thereof

A locking system for toolboxes, industrial cabinets and the like includes a push button operator assembly connected by at least one movable link to at least one latch mechanism configured to latchingly engage an associated striker to releasably retain a first structure (such as a closure) on which the striker is mounted in a closed position relative to a second structure (such as a cabinet) on which the locking system is mounted. The push button operator assembly has a button that, when unlocked, can be depressed to move the associated link to unlatch the latch mechanism from the striker, and that, when locked, is inoperable when depressed to move the link. Push button operator assemblies are disclosed that can move their associated links in one of two opposite directions (to accommodate the directions of link movement needed to operate the associated latch mechanisms), and these oppositely acting push button operator assemblies may be combined in a locking system where either can operate all of the latch mechanisms of the system.
Innovative reflex-based gait rehabilitation

Stroke is the third leading cause of disability, increasingly affecting individuals at the peak of their productive life representing an enormous impact on countries’ socio-economic development. Stroke rehabilitation is estimated in approx. €4.4bn in Europe and €3.3bn in the USA. The indirect cost to society (e.g. loss of productivity) is also severe, surpassing €11.5bn in the USA alone. 
Gait impairment is one of the most disabling sequelae of stroke, affecting 80% of stroke survivors, leading to independence loss, decreased self-reliance and declining in patients’ dignity, also with profound effects on caregivers (therapists or relatives). This makes gait recovery a major priority in the rehabilitation program for stroke survival patients. Conventional gait rehabilitation is based on physical therapy interventions where 2 physiotherapists are needed to start the training of a stroke patient: one holding the patient and another moving the foot of the hemiplegic limb.
Nordic-NeuroSTIM (NNS) is presenting Incedo (a device, an electrode and a foot sensor): a novel reflex-based technology for gait rehabilitation that in a clinical trial lead to a 20% improvement in gait speed and better gait symmetry as compared to conventional rehabilitation. This leads to increased independence and self-reliance of stroke patients, while perfectly adapts to the current clinical practice. Ultimately, Incedo reduces the number of needed physiotherapists involved in gait training from 2 to 1.
NNS has successfully launched Incedo™ in Denmark with very high impact in improving gait rehabilitation of stroke patients. The INNOGAIT innovation project will boost the market entrance and launching the system all over Europe and globally, helping to position NNS as the first mover in reflex-based neuroplasticity devices significantly reducing the socio-economic burden of gait impairment due to stroke.
Preparing for unveiling the nature of the cosmic acceleration

In less than a decade, various large cosmological surveys, such as Euclid, DESI and eROSITA, will start collecting data. These aim to bring ground-breaking changes to our understanding of the accelerated cosmic expansion - one of the grand challenges in physics today - by improving the precision in determining key cosmological parameters to percent level and testing the various theoretical models, such as dark energy and non-standard gravity. They will, for the first time, allow General Relativity to be tested to such precision beyond the local Universe. However, such exciting goals can only be achieved if the accuracy of theory predictions is greatly improved to match that of observations.

I propose to tackle this challenge by using state-of-the-art numerical techniques to study the leading theoretical models beyond standard LCDM in unprecedented accuracy, thereby preparing for their tests by 3 most promising cosmological probes - weak lensing, redshift space distortions and galaxy clusters. This numerically very demanding project is made possible by our recent developments of efficient simulation and analysis pipelines for each of these probes. I will build the PUNCA team which has a wide expertise to study constraints by these probes using accurate theoretical predictions from my planed simulations, and which will work closely to assess the power of novel joint constraints. To link model predictions to observations, and to understand critically their systematics, I will make realistic mock galaxy catalogs using simulations of unprecedented resolution and sophisticated galaxy formation models.

The results will have important implications for fully exploiting the potential of upcoming surveys (e.g. Euclid, DESI, of which I am an active member, and eROSITA) in testing models. The pipelines and expertise developed will be useful for analysing real data from those surveys. Given the starting times (2017-20) of the latter, this project (2016-21) is extremely timely.