SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Ocular Signs Correlate Well with Disease Severity and Genotype in Fabry Disease

Ocular signs in Fabry disease have generally been regarded to be primarily of diagnostic value. We explored whether ocular findings, alone or in particular in combination with the α-galactosidase A gene mutation, have predictive value for disease severity. Data from the Fabry Outcome Survey (FOS), a large, global database sponsored by Shire, were selected for adult patients who had undergone ophthalmological examination. Three ocular signs were assessed: cornea verticillata, tortuous conjunctival and/or retinal vessels, and cataract. Fabry disease severity was measured using FOS Mainz Severity Score Index and modifications thereof. Ophthalmological data were available for 1203 (699 female, 504 male) adult patients with eye findings characteristic of Fabry disease in 55.1%. Cornea verticillata had a similar distribution in women (51.1%) and men (50.8%), whereas tortuous vessels and Fabry cataract were somewhat more frequent in men than in women. Patients with cornea verticillata, selected as the principal ocular sign for this study, had more severe disease (median score, 20.0) versus those without ocular signs (11.0; P<0.001). This finding could be confirmed by applying age adjusted severity scores. Moreover, the prevalence of cornea verticillata was significantly higher in patients with null (male, 76.9%; female, 64.5%) and missense (male, 79.2%; female, 67.4%) mutations versus mild missense (male, 17.1%; female, 23.1%) and the p.N215S (male, 15.0%; female, 15.6%) mutations (P<0.01). Our analyses show a correlation between the prevalence of ocular changes in Fabry disease and disease severity. Consequently, information on ocular findings and α-galactosidase A gene mutation may help assess the risk for more severe Fabry disease. These observed findings are of notable clinical importance, as Fabry disease is characterized by high clinical course variability and only weak genotype-phenotype correlation at the individual patient level. Further confirmatory studies are needed.
Chemical constituents from Kandelia candel with their inhibitory effects on pro-inflammatory cytokines production in LPS-stimulated bone marrow-derived dendritic cells (BMDCs)

Chemical investigation of Kandelia candel resulted in the isolation of 19 compounds (1-19), including one new sesquiterpene glycoside, kandelside (1), three megastigman glycoside compounds (7-9), 16 known phenolic compounds (2-6 and 10-19). Structures of the isolated compounds were elucidated based on spectral data comparison with reported values. Isolated compounds were also evaluated for their inhibitory effects on the production of pro-inflammatory cytokines interleukin (IL)-12 p40, IL-6, and tumor necrosis factor α (TNF-α) in lipopolysaccharide (LPS)-stimulated bone marrow-derived dendritic cells. Among these compounds, compound 9 exhibited strong inhibitory activity against IL-6 production (IC50=0.07 ± 0.05 μM) and moderate inhibitory activity against TNF-α production (IC50=49.86 ± 1.02 μM), but exhibited no activity on IL-12 p40 production. Compounds 5 and 6 significantly inhibited IL-12 p40, IL-6, and TNF-α production with IC50 values of 11.68 ± 0.38, 44.52 ± 1.08, and 28.73 ± 0.96 μM, respectively.
Models and Modeling in the Sciences: preface to the Special Issue of the 12th Principia International Symposium

This Special Issue brings a selection of peer-reviewed papers that were presented at the 12th Principia International Symposium: Models and Modeling in the Sciences, Florianópolis, Brazil, online, August 2021. In this preface, the chair and the secretary of the organizing committee comment the symposium's context and briefly present the issue.
Method of preventing explosions using a smelt water explosion inhibitor

A method of preventing a physical explosion caused by the contact of water with a molten material such as molten smelt and molten metal by the addition of a porous, high surface area powder which is coated with an anti-wetting agent. The material sinks through the water layer to the interface between the water and the molten material carrying air or gas bubbles with it. The invention is particularly applicable to smelt-water explosion in kraft chemical recovery furnaces.
Communication storage optimization for static dataflow with access patterns under periodic scheduling and throughput constraint

We address a recently introduced static dataflow model: the Static Dataflow with Access Patterns (SDF-AP) model. For this model we present (1) a generalization of an existing regular periodic scheduling scheme to regular 1-periodic scheduling for flexibility to achieve a smaller schedule period and additional room for optimization on communication storage; (2) a method based on Integer Linear Programming (ILP) to minimize communication buffers under periodic scheduling and user-specified throughput constraints. Experimental results on a set of test cases show that buffer sizes using this approach can be reduced dramatically when compared to the traditional SDF models. The optimal sizing result may serve as an important criterion to evaluate and fine-tune any heuristics-based buffer sizing approach for the SDF-AP model of computation.
Spatial distribution of Crofton weeds in southwest China with MODIS NDVI of long time series

Crofton weed, which was introduced to the southwest of China in the 1940s via the border between China and Burma, now has a seriously damaging effect on the biodiversity and the living environment in those regions, including Yunnan, Sichuan, Guizhou, Guangxi, Tibet, Chongqing, and Hubei. To help monitor this situation effectively, there have been many researches that utilize remote sensing images to identify the spread of Crofton weed. However, most of these researches found it difficult to identify Crofton weed because it is mixed and entangled with a large number of other vegetation. In our research, data processing includes three steps: 1) Retrieving the spectral feature values of Crofton weed at the different growth stages through long time regional sampling; 2) Comparing the NDVI of Crofton weeds, forests, crops, water bodies, residential areas in the typical sampling regions by using the time series data of remote sensing images; and finally, 3) Classifying the remote sensing images of the research regions according to the distinctive features of NDVI curves based on the time series data. The outcome of following these three data processing steps is a relatively accurate classification result, which produces a high-accuracy distribution map of the Crofton weed.
Αυτόματη αναγνώριση CAPTCHAs με χρήση τεχνικών ΨΕΕ

It is fact that in the modern world the Internet offers a global communication while creating a global economy. The provision of free services from several websites has led to this systematic abuse solely for the purpose of making a profit. In order to stem the tide of this malicious new source of income for some, “CAPTCHAs” are employed. Their goal is to determine whether a request to a service is made by a user or by an automated program. Every website that enables the user to create their own content or use its services must now deploy CAPTCHAs.
This current special scientific work aims at the study and interpretation of all different kinds of CAPTCHAs created so that they are resistant to malicious efforts of solutions and examines whether this is possible. An attempt is made initially to understand exactly what the “CAPTCHAs” are and why their use is necessary. What will also be explored through specific publications made, is what principles should govern the design of a CAPTCHA. In order to do this we will go back to different approaches and after presenting them, a critical analysis of the methods of each research group will be conducted.
Modeling fluid structure interaction with shape memory alloy actuated morphing aerostructures

The development of efficient and accurate analysis techniques for morphing aerostructures incorporating shape memory alloys (SMAs) continues to garner attention. These active materials have a high actuation energy density, making them an ideal replacement for conventional actuation mechanisms in morphing structures. However, SMA components are often exposed to the same highly variable environments experienced by the aeroelastic assemblies into which they are incorporated. This is motivating design engineers to consider modeling fluidstructure interaction for prescribing dynamic, solution-dependent boundary conditions. This work presents a computational study of a particular morphing aerostructure with embedded, thermally actuating SMA ribbons and demonstrates the effective use of fluid-structure interaction modeling. A cosimulation analysis is utilized to determine the surface deflections and stress distributions of an example aerostructure with embedded SMA ribbons using the Abaqus Finite Element Analysis (FEA) software suite, combined with an Abaqus Computational Fluid Dynamics (CFD) processor. The global FEA solver utilizes a robust user-defined material subroutine which contains an accurate three-dimensional SMA constitutive model. Variations in the ambient fluid environment are computed using the CFD solver, and fluid pressure is mapped into surface distributed loads. Results from the analysis are qualitatively validated with independently obtained data from representative flow tests previously conducted on a physical prototype of the same aerostructure.
LOW-POWER DUAL DOWN-CONVERSION WI-FI WAKE-UP RECEIVER

A Wi-Fi wake-up receiver that receives wake-up signals encoded using orthogonal frequency division multiplexing based on-off keying (OFDM-OOK) modulation includes receiver circuitry having analog envelope detector circuitry configured to non-linearly down-convert an input signal and provide an energy signal for sampling by an analog-to-digital converter (ADC). A wake-up signal for waking up a main radio in a Wi-Fi device can be based on the digitized energy signal. The receiver circuitry can further include, upstream of the envelope detector circuitry and the ADC in the signal chain, an analog mixer for linearly down-converting the input signal and a low-pass filter for attenuating adjacent-channel interferer (ACI) signals prior to the non-linear down-conversion by the envelope detector circuitry. Sampling of the energy signal rather than the higher-bandwidth input signal yield power savings in the ADC and associated circuitry such as a modem.
A Weather Dependent Failure Rate Model for Overhead Lines

In power system planning and operation, accurate assessment of overhead lines outage rate is essential for making timely decisions. The overhead lines are often influenced by many random events, such as accidents and weather conditions, resulting in power outages. Especially, the reliability of the overhead lines is subjected to weather conditions to a great extent[9]. At present, research about weather conditions dependent reliability is abundant, but many of them are based on synthetical weather, little of them base on specific weather conditions such as typhoon and thunder .This paper proposed outage model of overhead lines dependent upon typhoon an thunder. In power system planning and operation, accurate assessment of failure rate is essential for making informed decisions, The outage model proposed in this paper has significant meaning for the research of risk assessment of power systems.
The european union and its normative power in a post-conflict society: a case study of northern kosovo

This project aims to study the role of normative power of the EU in the post-conflict society of northern Kosovo and to explore how has the signing of the Brussels agreement changed the dynamics of relations at both intra-societal (within the community of Serbs of northern Kosovo) and inter-ethnic level (Serbs of northern Kosovo vs. Kosovo Albanians and the institutions of the Kosovo government). 
The project would: 1. explore the motivation and driving factors of Kosovo Serbs for their positive/negative stance regarding the signature of the Brussels agreement and the cooperation with the institutions of the Government of Kosovo and Kosovo Albanians in general; 2. assess the intra-societal split within the Serb community in northern Kosovo between those who cooperate with the institutions of the Government of Kosovo and Kosovo Albanians in general, and those who still reject any kind of cooperation, and how is the intra-societal conflict (pressure) manifested; 3. evaluate the impact of normative power of the EU in northern Kosovo; 4. assess the changes in the patterns of relations between Serbs from northern Kosovo and Kosovo Albanians on political, institutional and societal level after the signing of the Brussels agreement; 5. draw policy implications for the EU Common Foreign and Security Policy. 
This research project draws from three theoretical backgrounds: the theory of normative power, ‘theories’ of peacebuilding, conflict prevention and conflict resolution, and the theory of intra-societal conflict. The following research methods would be applied: interviews, surveying, focus groups (field-work in Kosovo), and study of primary and secondary sources.
From theoretical viewpoint, this project is innovative, as it questions the impact of EU’s normative power in a post-conflict society. This project is relevant because certain policy implications (recommendations) for the EU Common Foreign and Security Policy could be drawn from it.
The Dynamic Change and Main Driving Factors of Forest Resources in Guangxi from 1977 to 2010

There was dramatic change of forest resources in Guangxi from 1977 to 2010. The woodland area increased from 13. 9 632 million hm2to 15. 2 717 million hm2,with 9.37% increasing. The forest land area increased from 5. 3 136 million hm2to 11. 1 638 million hm2,with 110.10% increasing. The growing stock volume increased from 256 million m3to 558 million m3,with 117.97% increasing. Based on the results of continuous forest inventory,the dynamic change of the forest resources and the main driving factors on the policies and benefits were clarified and analyzed,and the countermeasures and suggestions for the forest management in the future were proposed.
Passive seismic measurement of seismic attenuation in Delaware Basin

Local earthquake activity can be employed to measure attenuation (the effective quality factor [Q]) and characterize production in the Delaware Basin, Texas, USA. To illustrate this, we employed data from the recently installed Texas Seismic Network (TexNet) seismic stations collected in the west Texas area between April 2017 and March 2018. Earthquake activity in the Delaware Basin has increased in comparison to the previous 20 years, which has resulted in numerous high-quality events suitable for this analysis. The high signal-to-noise ratio events were used to estimate effective Q factors using the peak frequency method on the sediments of the Delaware Basin. The effective attenuation of the sedimentary basin is 90 for P-waves and 140 for S-waves (both with uncertainty of approximately 30), indicating an unusually low attenuation (high Q) for S-waves relative to the P-waves. This is consistent with attenuation of a saturated sedimentary basin because the saturation results in less attenuation of S-waves. Additionally, we observe an increase of the effective Q factor with distance between the station and events consistent with rays sampling the deeper, less-attenuating, and less-saturated portions of the basin and even basement. Inverted effective attenuation coefficients were used to calculate moment magnitudes, which were consistent with those seen in the TexNet array.
DIRECTIONAL MICROPHONE

A directional microphone system includes an ultrasonic emitter and receiver. The emitter directs a beam of ultrasound at the audio source with sufficient intensity that non-linear air effects cause non-linear interactions between the ultrasonic sound and the source's sonic sound. Ultrasonic frequency-mired sounds are thereby generated and these are received by the ultrasonic receiver. Signal-processing is carried out on the received signals to strip out the audio signals. The emitter and receiver may be co-located and the emitted beam may be focussed at the location of the audio source. The receiver may also be directional acid focussable. The directional microphone system may be very small and yet highly directional at sonic including low audible frequencies.
Evone® Flow controlled ventilation: a new device for laryngotracheal surgery

Evone® Ventilazione a flusso controllato: un nuovo dispositivo per la chirurgia laringo-tracheale.Il successo della chirurgia laringotracheale è principalmente correlato a un’adeguata esposizione delle vie aeree, con l’utilizzo di un tubo oro-tracheale più piccolo possibile. Il primo tentativo è stato fatto introducendo la tecnologia della ventilazione a getto ad alta frequenza (VGAF) nella pratica clinica. Tuttavia, la VGAF presenta alcuni rischi legati all’alta pressione necessaria per la ventilazione. Innanzitutto, durante la VGAF, l’espirazione dell’aria dai polmoni è un riflusso passivo sulla parete della trachea, che potenzialmente causa ipercapnia e intrappolamento d’aria. In secondo luogo, la VGAF crea un sistema di ventilazione aperto che aumenta il rischio infettivo per il personale sanitario, a causa dei droplets immessi in circolo tramite aerosol. Per superare questi problemi, è stato introdotto nella pratica clinica un innovativo sistema di ventilazione a flusso controllato con catetere a cuffia stretta (Evone®; Ventinova, Eindhoven, Paesi Bassi). Questo articolo descrive la nostra esperienza iniziale con il sistema Evone®, riportando i primi 5 casi di pazienti ventilati con questa tecnologia. In questo studio osservazionale, valutiamo la fattibilità e la sicurezza del sistema Evone® e forniamo una valutazione critica di questo nuovo metodo di ventilazione.The success of laryngotracheal surgery is mainly related to adequate exposure of the airway lumen. To render airway surgery more efficient, many efforts have been made in recent decades to obtain a safe ventilation system which uses an orotracheal tube that is as small as possible. The first attempt was made by introducing the high frequency jet ventilation (HFJV) technology in clinical practice. Nonetheless, HFJV has some risks related to the high pressure needed for ventilation in the catheter. First, during HFJV, the expiration of air from the lungs is a passive backflow on the trachea wall, potentially causing hypercapnia and air trapping. Second, HFJV creates an open ventilation system that leads to aerosolisation of airborne particles with an increased infectious risk for the surgeon. To overcome these issues, an innovative flow-controlled ventilation (FCV) system with a narrow-cuffed catheter (Evone®; Ventinova, Eindhoven, The Netherlands) was introduced in clinical practice. This paper describes our initial experience with the Evone® FCV system, reporting the first 5 cases ventilated with this technology. In this observational study, we evaluate the feasibility and safety of the Evone® system and deliver a critical appraisal of this novel method of ventilation.
Mapeamento da isoterma de Curie na Bacia do Parnaíba estimada através da profundidade da base das fontes magnéticas

Located on the western edge of the Brazilian northeast, the Parnaiba Basin is an
intra cratonic basin with oil production. This study aims at understanding its genesis
and evolution, using aeromagnetic and gravity data. We used the spectral analysis of
aeromagnetic data to map the depth to the bottom of the magnetic sources in order to
assimilate this depth with the depth of the Curie isotherm, and infer the geothermal
gradient.
Using the spectral analysis technique, we succeeded in mapping the surface of
the depth to the bottom of magnetic sources (SBFM), which marks the depth that
occur magnetization. In the Parnaiba Basin the SBFM presented depths around -20,5
and -28,5 , which was consistent with an inversion of the same dataset using the
technique of Magnetization Vector Inversion (MVI). Furthermore, SBFM topography
correlates well with Moho depth, which was estimated from satellite gravimetric data
from the GOCE mission (Gravity Field and Steady-State Ocean Circulation Explorer).
Assuming that SBFM coincides with the Curie isotherm of magnetite (ICM),
defined as the surface at which magnetite ( ) looses its ferromagnetic properties,
it was possible to estimate the geothermal gradient. The geothermal gradient in the
basin showed values between 19.2 and 26.5 , allowing to estimate the heat flow
for the Parnaiba basin after assuming a conductivity of 2.69

. The resulting
heat flow values ranged between 51.6 and 71.3
, which is consistent with
values found in other works throughout the South American continent. Lithospheric
thickness using an empirical relationship, finding values between -65.8 and -89.2 .
We propose that thermal structure of Parnaiba basin is influenced by a deep
thermal anomaly. This anomaly has heated the lithosphere beneath the basin and has
resulted in relatively thin values for the lithospheric thickness and relatively high
surface heat flow values. The origin of the anomaly is not clear, but the correlation
between Curie depth and Moho topography, suggests that tectonic extension processes
could have played a role.
STRATEGIE DI COFFEE DESIGN PER IL FUTURO DEL CAFFÃ  ARABICA

LÂ¿OBIETTIVO PRINCIPALE DEL PROGETTO CONSISTE NELLÂ¿ISOLARE E CARATTERIZZARE I LOCI NEL GENOMA DI C. ARABICA CHE CONFERISCONO RESISTENZA ALLA RUGGINE FOGLIARE, LOCI PRESENTI NELLÂ¿IBRIDO DI TIMOR E IN VARIETÃ  COMMERCIALI RESISTENTI A QUESTÂ¿INFEZIONE PORTATA DAL FUNGO HEMILEIA VASTATRIX. LA CONOSCENZA DETTAGLIATA DEI FATTORI DI RESISTENZA ALLA RUGGINE FOGLIARE PORRÃ  LE BASI PER I FUTURI INTERVENTI DI MITIGAZIONE DELLÂ¿IMPATTO DEL CAMBIAMENTO CLIMATICO SULLA COLTIVAZIONE DI CAFFÃŠ, ASSICU
Rethink

Science communication is at a pivotal stage in its evolution due to the emergence of digital communication platforms that are not only presenting new opportunities but are also leading to new challenges. RETHINK will provide an unprecedented view of the new science communication landscape to reveal the barriers and inequalities that stand in the way of open and reflexive connections between science and society. It will also present the way forward, encouraging evidence-based transformations in science communication practice as well as guiding relevant policy to further open Research & Innovation (R&I) to society.To achieve this, RETHINK will provide a 360° view of the current science communication landscape. It will map current science communication activities across Europe, including those taking place in the currently uncharted digital sphere. It will seek input from R&I stakeholders who are currently disengaged with science communication. 

Outputs will be new ways of training those who engage in science communication, including those underserved by current training - such as bloggers and social media commentators. There will be online briefs aimed at changing current science communication practices to break down barriers preventing open R&I and reach underserved audiences across the EU. Strategies will be developed to improve individual and collective sensemaking by enhancing its openness and reflexivity. Guidance on policy will also be provided to create an environment that encourages open R&I. All of these outputs will be open access, as will the data generated during the research process to encourage a broad discussion and maximise uptake.

RETHINK will bring about meaningful, long-term change in science communication to maximise the opportunities and overcome the challenges of digitalisation, allowing the sector to help society meet key challenges across the European community and beyond.