SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Physiology of the read-write genome

Discoveries in cytogenetics, molecular biology, and genomics have revealed that genome change is an active cell-mediated physiological process. This is distinctly at variance with the pre-DNA assumption that genetic changes arise accidentally and sporadically. The discovery that DNA changes arise as the result of regulated cell biochemistry means that the genome is best modelled as a read-write (RW) data storage system rather than a read-only memory (ROM). The evidence behind this change in thinking and a consideration of some of its implications are the subjects of this article. Specific points include the following: cells protect themselves from accidental genome change with proofreading and DNA damage repair systems; localized point mutations result from the action of specialized trans-lesion mutator DNA polymerases; cells can join broken chromosomes and generate genome rearrangements by non-homologous end-joining (NHEJ) processes in specialized subnuclear repair centres; cells have a broad variety of natural genetic engineering (NGE) functions for transporting, diversifying and reorganizing DNA sequences in ways that generate many classes of genomic novelties; natural genetic engineering functions are regulated and subject to activation by a range of challenging life history events; cells can target the action of natural genetic engineering functions to particular genome locations by a range of well-established molecular interactions, including protein binding with regulatory factors and linkage to transcription; and genome changes in cancer can usefully be considered as consequences of the loss of homeostatic control over natural genetic engineering functions.
Improving governance, management and sustainability of rural and coastal protected areas and contributing to the implementation of the Natura 2000 provisions in IT and GR

• BIG general objective is to improve governance, management and sustainable valorization of coastal and rural protected areas and contributing to the implementation of the Natura 2000 provisions in Greece and Italy. The sub-objectives are:
• Strengthening and improving cooperation among regional administrations to further monitor Natura 2000 species and habitats and to set environmental measures for the next programming period (networking, setting common standards, creating databases and setting measures based on the updated biodiversity status).
• Setting cross-border strategies and supporting decision-makers for management and valorization of protected areas and Natura 2000 sites.
• Developing actions for the management and valorization of pilot rural and coastal ecosystems that consists of on-the-ground interventions in the parks of both countries and/or Natura 2000 sites.
• Promoting sustainable tourism in protected areas via networking, implementation of concrete actions and transfer of best practices.
Impact of heparanase on renal fibrosis

Tubulo-interstitial fibrosis has been recognized as the hallmark of progression of chronic kidney disease, but, despite intensive research studies, there are currently no biomarkers or effective treatments for this condition. In this context, a promising candidate could be heparanase-1 (HPSE), an endoglycosidase that cleaves heparan sulfate chains and thus takes part in extracellular matrix remodeling. As largely described, it has a central role in the pathogenesis of cancer and inflammation, and it participates in the complex biological machinery involved in the onset of different renal proteinuric diseases (e.g., diabetic nephropathy, glomerulonephritis). Additionally, HPSE may significantly influence the progression of chronic kidney damage trough its major role in the biological pathway of renal fibrogenesis. Here, we briefly summarize data supporting the role of HPSE in renal damage, focusing on recent evidences that demonstrate the capability of this enzyme to modulate the signaling of pro-fibrotic factors such as FGF-2 and TGF-β and consequently to control the epithelial-mesenchymal transition in renal tubular cells. We also emphasize the need of the research community to undertake studies and clinical trials to assess the potential clinical employment of this enzyme as diagnostic and prognostic tool and/or its role as therapeutic target for new pharmacological interventions.
Injectable hydrogel scaffold from decellularized human lipoaspirate

Soft tissue fillers are rapidly gaining popularity for aesthetic improvements or repair of adipose tissue deficits. Several injectable biopolymers have been investigated for this purpose, but often show rapid resorption or limited adipogenesis and do not mimic the native adipose extracellular matrix (ECM). We have generated an injectable adipose matrix scaffold by efficiently removing both the cellular and lipid contents of human lipoaspirate. The decellularized material retained the complex composition of peptides and glycosaminoglycans found in native adipose ECM. This matrix can be further processed by solubilizing the extracted ECM to generate a thermally responsive hydrogel that self-assembles upon subcutaneous injection. This hydrogel also supports the growth and survival of patient matched adipose-derived stem cells in vitro. The development of an injectable hydrogel from human lipoaspirate represents a minimally invasive option for adipose tissue engineering in terms of both the collection of source material and delivery of the scaffold.
ATTACHING ARRANGEMENT FOR HAND-HELD MOTOR-DRIVEN TOOLS

The invention relates to an arrangement for attaching a bar (1) of a hand-held motor driven tool, such as a chain saw, to a body (2) of the tool, the arrangement comprising: at least one bolt (3), having a first part (3a), securely arranged to the body (2), and a second part (3b) extending from the body, the second part having an engagement portion (3c) for engaging a nut (5, 15); a cover portion (4, 14) adapted to bear against a bar (1) such that the bar is arranged between the cover portion (4, 14) and the body (2); and at least one nut (5, 15), captively attached to the cover portion (4, 14). The nut is adapted to engage the engagement portion (3c) of the bolt (3) for securing a bar (1) between the cover portion (4, 14) and the body (2), the nut (5, 15) having a rotation axis (X). The nut is also arranged to move a first distance (A) along the engagement portion (3c) of the bolt (3), in a direction of its rotation axis (X), for securing a bar (1) between the cover portion (4, 14) and the body (2). When the bolt (3) and the nut (5, 15) are not engaged, the nut (5, 15) is captively attached to the cover portion (4, 14) in such a way that it is movable a second distance (B) relative the cover portion (4, 14) in a direction of its rotation axis (X), wherein the second distance (B) is larger than the first distance (A).Thereby, an attachment arrangement is achieved that facilitates changing of bars when the nut used in the attachment arrangement is captively arranged to the cover portion.
Tannin-Based Resins for 3D printing of Porous Carbon Architectures

come from teaching and research institutions in France or abroad, or from public or private research centers.L'archive ouverte pluridisciplinaire HAL, est destinée au dépôt et à la diffusion de documents scientifiques de niveau recherche, publiés ou non, émanant des établissements d'enseignement et de recherche français ou étrangers, des laboratoires publics ou privés.
The Nano-X Linear Accelerator

Rapid technological improvements in radiotherapy delivery results in improved outcomes to patients, yet current commercial systems with these technologies on board are costly. The aim of this study was to develop a state-of-the-art cancer radiotherapy system that is economical and space efficient fitting with current world demands. The Nano-X system is a compact design that is light weight combining a patient rotation system with a vertical 6 MV fixed beam. In this paper, we present the Nano-X system design configuration, an estimate of the system dimensions and its potential impact on shielding cost reductions. We provide an assessment of implementing such a radiotherapy system clinically, its advantages and disadvantages compared to a compact conventional gantry rotating linac. The Nano-X system has several differentiating features from current radiotherapy systems, it is [1] compact and therefore can fit into small vaults, [2] light weight, and [3] engineering efficient, i.e., it rotates a relatively light component and the main treatment delivery components are not under rotation ( e.g., DMLCs). All these features can have an impact on reducing the costs of the system. In terms of shielding requirements, leakage radiation was found to be the dominant contributor to the Nano-X vault and as such no primary shielding was necessary. For a low leakage design, the Nano-X vault footprint and concrete volume required is 17 m2 and 35 m3 respectively, compared to 54 m2 and 102 m3 for a conventional compact linac vault, resulting in decreased costs in shielding. Key issues to be investigated in future work are the possible patient comfort concerns associated with the patient rotation system, as well as the magnitude of deformation and subsequent adaptation requirements.
Timing Analysis of Event-Driven Programs with Directed Testing

Accurately estimating the worst-case execution time (WCET) of real-time event-driven software is crucial. For example, NASA's study of unintended acceleration in Toyota vehicles highlights poor support in timing analysis for event-driven code, which could put human life in danger. WCET occurs during the longest possible execution path in a program. Static analysis produces safe but overestimated measurements. Dynamic analysis, on other hand, measures actual execution times of code under a test suite. Its performance depends on the branch coverage, which itself is sensitive to scheduling of events. Thus dynamic analysis often underestimates the WCET. We present a new dynamic approach called event-driven directed testing. Our approach combines aspects of prior random-testing techniques devised for event-driven code with the directed testing method applied to sequential code. The aim is to come up with complex event sequences and choices of parameters for individual events that might result in execution times closer to the true WCET. Our experiments show that, compared to random testing, genetic algorithms, and traditional directed testing, we achieve significantly better branch coverage and longer WCET.
Volumetric medical x-ray imaging at extremely low dose

Computerized Tomography (CT) has been one of the greatest achievements in medical imaging, but at the cost of a high, potentially harmful, X-ray irradiation dose. The ultimate goal of VOXEL is to provide an alternative to tomography with a disruptive technology enabling 3D X-ray imaging at very low dose. VOXEL aims at prototyping new cameras that will combine the X-ray penetration and nanometre spatial resolution, easiness to use, afforded by avoiding the rotation of the source or the sample, and extremely low dose for maximum impact on medicine and biology. 
VOXEL relies on the integration of trans-disciplinary fields in medical imaging, optics, X-ray physics, applied mathematics and value to society through foreseeable commercialization. VOXEL aims at prototyping in parallel a soft X-ray “water window” microscope and a hard X-ray 3D camera for medical applications. While both cameras need groundbreaking development in the underlying physics, only hard X-ray camera has high technological risk (and high societal impact). VOXEL will benefit from the soft X-ray camera thanks to its Biological applications in nano-tomography but also as a test platform for our physical and mathematical models..
The VOXEL team members are leaders in X-ray metrology, wavefront sensing, atomic physic, mathematical computing and 3D medical imaging; with VOXEL we are uniquely positioned to succeed, and to raise the competitiveness of Europe. Doing so by basing the research lead in Portugal with a woman coordinator will be exemplary: beyond the scientific and technological success, thanks to our focus in science and its valorisation, VOXEL will be transformative for scientifically emerging countries.
Las piraguas de La Marmotta, auténtica ingeniería para navegar por el Mediterráneo durante la expansión neolítica

Este trabajo tiene como eje discursivo la información publicada sobre dos de las cinco piraguas neolíticas documentadas en el asentamiento neolítico de La Marmotta (Anguillara Sabazia, Lazio, Italia), y como este hallazgo puede darnos nuevos datos sobre la navegación y la expansión neolítica por el Mediterráneo. Se trata de un yacimiento excepcional, pues el hecho de hallarse en el fondo del Lago di Bracciano ha permitido que se conservaran extraordinarios restos bióticos. Las características de estas piraguas, así como del conjunto de elementos navales asociados, nos demuestran que estamos ante sociedades complejas en su organización social, con unos conocimientos tecnológicos difícilmente imaginables. Conocer La Marmotta es comprender mucho mejor las sociedades neolíticas y el éxito de su expansión. Sin duda conocían muy bien la navegación y el mar Mediterráneo. De lo contrario es difícil suponer cómo iniciaron su diáspora hace unos 10000 años BC desde Próximo Oriente y llegaron a las costas portuguesas hacia el 5400 BC. Domesticaron las plantas y los animales, y revolucionaron todo el espectro técnico que, gracias a yacimientos como La Marmotta, podemos evaluar. Sin duda, somos los herederos de aquellas sociedades.
« Est-ce que je suis assez bonne pour être ici ? » : anxiété langagière et discrimination linguistique en contexte scolaire québécois

Cette étude qualitative décrit les expériences vécues par des étudiants universitaires québécois (n = 18) dont les parents sont nés en Amérique latine, tout au long de leur parcours éducatif. L’analyse révèle l’existence d’une frontière entre ceux qu’ils nomment les Québécois francophones et les autres. Pour eux, cette frontière axée sur une différence linguistique — souvent attribuée à leur accent — les amène à ressentir de l’anxiété langagière et de la discrimination linguistique. Ils relatent que le système éducatif ne prendrait pas suffisamment en compte leurs difficultés. La conclusion identifie des pistes d’intervention valorisant le plurilinguisme pour favoriser leur inclusion.
OPTIMIZATION DESIGN METHODS OF OPTIMUM ROP

During drilling, drilling time has obvious difference for different drill site under the condition of the same total depth and same structure, apart from the influential factor of formation characteristics, engineers’ technical ability plays an important role in determining drilling time. At present, evaluating ROP usually compares with adjacent wells real drilling data, which is lack of adequate data for effective assessment the new development fields. Therefore, in this paper, a new method of evaluating the performance of the drilling was established in considering the drilling parameter, make-up of string and subsurface safety etc. The new evaluation method applied optimizing drilling parameters to improve ROP and save drilling cost.
An analytical model for studying the structural effects and optimization of a capacitive tactile sensor array

This paper presents an analytical model to study the structural effects of a capacitive tactile sensor array on its capacitance changes and sensitivities. The tactile sensor array has 8 × 8 sensor units, and each unit utilizes the truncated polydimethylsiloxane (PDMS) pyramid array structure as the dielectric layer to enhance the sensing performance. To predict the capacitance changes of the sensor unit, it is simplified into a two-layered structure: upper polyethylene terephthalate (PET) film and bottom truncated PDMS pyramid array. The upper PET is modeled by a displacement field function, while each of the truncated pyramids is analyzed to obtain its stress–strain relation. Using the Ritz method, the displacement field functions are solved. The deformation of the upper electrodes and the capacitance changes of the sensor unit can then be calculated. Using the developed model, the structural effects of the truncated PDMS pyramid array and the PDMS bump on the capacitance changes and sensitivities are studied. To achieve the largest capacitance changes, the dimensions have been optimized for the sensor unit. To verify the developed model, we have fabricated the sensor array, and the average sensitivities of the sensor unit to the x-, y-, and z-axes force are 0.49, 0.50, and 0.32% mN−1, respectively, while the model predicted values are 0.54, 0.54, and 0.35% mN−1. Results demonstrate that the developed model can accurately predict the sensing performance of the sensor array and could be utilized for structural optimization.
Improving bud sprouting, growth and yield of winter initiated sugarcane ratoon through tillage cum organic mediated rhizospheric modulation in Udic ustochrept under subtropical Indian condition

Abstract Field experiment was conducted during 2007–2010 at research farm of Indian Institute of Sugarcane ( Saccharum officinarum ) Research, Lucknow. The findings of the investigation revealed that tillage operation performed by Ratoon Management Device (RMD) involving earthing-up from both the sides of sugarcane stubble protects the subterranean buds from cold injury and provides congenial rhizospheric environment for survival and sprouting of buds. Tillage through RMD superimposed with composted trash regulates the soil microbial activities (ex situ soil respiration – 29.52 mg CO 2 -C kg −1  soil day −1 and soil microbial biomass carbon (SMBC) – 187.3 mg C microb  kg −1  soil day −1 ). These in turn enhance the sprouting of stubble buds which otherwise fail to sprout under the influence of extremely low temperature. The tillage cum organic treatments creates congenial soil–water–air relations which produce viable and vigorous sprouts. Translated into practice, it means that the fact ‘Tillage is manure’ is quite pertinent in winter initiated sugarcane ratoon as mechanical manipulations of soil (tillage) at its optimum moisture level creates favourable physical environment (soil tilth) in root zone (bulk density – 1.35 Mg m −3 at 0–15 cm soil depth and infiltration rate – 5.5 mm h −1 ). Addition of organics further provides congenial substrate/s to soil microbiota and enhances their metabolic activities which along with new activated roots maintain better soil–water–air relations and enhancing their sprouting in cold conditions. This ensures synchronized, early formed adequate number of millable canes (135,000 ha −1 ), consequently resulting in higher ratoon cane (94.1 Mg ha −1 ) and sugar yields (8.75 Mg ha −1 ). The tillage cum organic technology is of immense significance to cane growers by increasing sugar yield in early crushing season from ratoon.
How strong is the impact of the Indo-ocean dipole on the surface air temperature/sea level pressure anomalies in the Mediterranean region?

Abstract The aim of this paper is to study the interannual climate variability over the Mediterranean region related to the Indo-ocean dipole (IOD) using the data of re-analyses, archival data and specialized numerical experiments. It is shown that the IOD does not impact essentially the anomalies of surface air temperature (SAT) and sea level pressure (SLP) in the Mediterranean region. On average, the IOD-induced share of the SAT/SLP variance in the total variance of these fields in the Mediterranean region is smaller than 10% even in summer when it is at a maximum. However, the statistically significant IOD-induced SAT/SLP anomalies in the Mediterranean region are detectable. For definite IOD events the associated Mediterranean SAT anomalies can reach about 1 °C.
Vaginal arco-colposuspension device for the treatment of urinary  incontinence in women

Stress Urinary Incontinence (SUI), referring to the involuntary leakage of urine, is a disease that causes embarrassment to sufferers that can lead to isolation, depression, and limitations in working and social life, especially exercise and leisure activities. Our VACS-D will disrupt existing applications for treatment by not only lowering the costs of healthcare making it more accessible by a larger population but also provide a pain free and long lasting solution that will also increase the quality of life as the world population age increases. VACS-D helps a major part of population – women- anywhere in the world. The women’s health is NOT just important for themselves but also from the sustained quality of motherhood as they raise the next generation.

This is a new device with a patent pending (PCT/tr2019/050048) device for the treatment of SUI in women with the power of changing their lives for the better as they age. VACS-D preserves the advantages while eliminating the disadvantages of two surgical methods that were considered the optimum approach in 1965 and 2000. The device enables surgeons to perform surgery via the vagina in a minimally invasive way, with only a single incision and with no need for an artificial implant (mesh), relying instead on native tissue repair. The use of mesh was suspended in the UK in 2018 and in the USA after the reports of FDA in 2008 advising against their use. VACS-D facilitates a new surgical approach that will become the method of choice in the treatment of urinary incontinence in women.  

Our multidisciplinary team has extensive clinical and surgical experience in both abdominal colposuspension and midurethral sling operations approaches to the surgical treatment of urinary incontinence. In 2018, the founder, gynecologist and obstetrician Assoc. Prof. Dr. Özgür Yeniel formed a multidisciplinary team after recognizing the need for a new surgical approach.
Defining torture: A review of 40 years of health science research

The current review critically examines the body of torture research (N = 209), focusing on the definition and operationalization of the primary construct. Almost three-quarters (69.9%) of the studies reviewed did not reference any definition of torture. Few studies identified important contextual variables related to defining torture such as identities and motivations of perpetrators and severity of abuse. Definitional ambiguity further impacted how individuals were queried about their experiences and the extent to which torture was distinguished from other forms of maltreatment. Although there are notable exceptions, the methods used in the torture literature are variable and often undefined, impacting the interpretation of findings of risk factors, consequences, and treatment of torture events.
Multi-scale quantitative elastography and its application to blood pressure estimation

Elastography is a method that can be used to measure
the elasticity of soft biological tissue and, ultimately, to detect
cancerous tumors. In this thesis, quantitative compression based
ultrasound elastography is developed using a fast multi-scale
approach. The inverse problem optimization methods of elastography
are applied to estimate noninvasively the arterial wall stiffness
of a vessel as well as blood pressure. Simulation and experimental
results are presented that predict the accuracy of the methods. A
method is also introduced to eliminate the need for a reference
pressure during the optimization over blood pressure. Using
ultrasound, these techniques could provide noninvasive continuous
measurement of blood pressure in major arteries and could give
doctors another way to gather information about a patients
cardiovascular health.