SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
An optimal market-oriented demand response model for price-responsive residential consumers

For many years in the wholesale electricity market, the generation companies would only seek to compete with each other to sell electric energy to customers in a way to make more profit. Moreover, there was no mechanism in such an environment to enable demand-side participation especially for residential building units with relatively high power consumptions. This caused the increasing market power of generation companies and soon to realize that the demand side would yield to any price to purchase the required energy. Having gradually identified this issue, demand response (DR) programs were introduced as confronting tools to help consumers being away from such situations. This paper proposes an effective market-oriented DR model for residential consumers to change their consumption patterns over the time for getting maximum benefits based on their own utility functions. According to the results of simulated case studies, it is demonstrated that the proposed model is able to adapt to different consumers with different levels of flexibility against the price signals. Moreover, simulation results demonstrate that the residential consumption levels can be easily adjusted during the examined period in a way not only to meet the user’s objectives, but also to reshape and smooth the system’s aggregated load profile.
Efficient assignment respecting priorities

Abstract A widespread practice in assignment of heterogeneous indivisible objects is to prioritize some recipients over others depending on the type of the object. Leading examples include assignment of public school seats, and allocation of houses, courses, or offices. Each object comes with a coarse priority ranking over recipients. Respecting such priorities constrains the set of feasible assignments, and therefore might lead to inefficiency, highlighting a tension between respecting priorities and Pareto efficiency. Via an easily verifiable criterion, we fully characterize priority structures under which the constrained efficient assignments do not suffer from such welfare loss, and the constrained efficient rule (CER) is indeed efficient. We also identify the priority structures for which the CER is singleton-valued and group strategy-proof.
Perseverance, Success, insertion, motivation, cross-border educative alliance for  school dropout prevention.

Valle d’Aosta Region and Provence-Alpes-Côtes d’Azur Region know a high rate of early school leaving, respectively 20 and 11%. PRIMO project wants to prove, in the same time, a prevention system against the early school leaving, from previous experiences proved on the territory, and try new ones. The multidimensional approach is possible with a multisector partnership (competent institutions in the field of education and social policies, organism of formation, Universities), and of the cross-border cooperation for practice exchanges and a common formation of teachers and formators. The project will produce
Establishing services enhancing the innovation management capacity of sme´s in hamburg and schleswig-holstein

The four partners Investitionsbank Schleswig-Holstein (IB.SH), TuTech Innovation GmbH (TuTech), Wirtschaftsförderung und Technologietransfer Schleswig-Holstein (WTSH) and IFB Hamburg (IFB) are part of the Enterprise Europe Network (EEN) consortium in Hamburg and Schleswig-Holstein and established a well-known regional one-stop-shop for all EU-related enquiries for SMEs and regional stakeholders.
For the period 2017-18 core objective is to expand the client base and deepen the level of assistance by offering the new service of “Key Account Management” (KAM) and “Enhancing SME Innovation Management Capacity” (IMC). Aim is to face existing lack of innovation management capacity in small and medium sized companies (SME) and support their innovative activities in order to creating economic impact. The guiding principle is that the services are tailored to the needs of the identified regional innovators and innovation systems.
In this context the KAM is targeted at beneficiaries of the SME instrument under Horizon 2020, the EIMC addresses other highly innovative SMEs. The EIMC helps companies to establish effective innovation management systems that enhance the realisation of growth opportunities. The KAM focuses on those weaknesses which endanger the success of the funded project. It assists in finding specialised coaches and establishing a coach-client relationship. Both approaches aim to raise the company´s competitiveness and profitability.
In the framework of the project the consortium acquired user licenses for the IMP3rove tool in order to assess gaps and needs of the SMEs. In this context senior staff of the EEN attended training to ensure that the tool is used correctly and the assessment exercise complies with the envisaged EU standard. In addition the participation in training courses gives the chance for a best practice exchange with other EEN colleagues and is of great benefit for the consortium.
Safety and efficacy of S-1 chemotherapy in recurrent and metastatic nasopharyngeal carcinoma patients after failure of platinum-based chemotherapy: multi-institutional retrospective analysis

This retrospective study evaluates the efficacy and safety of S-1 chemotherapy for recurrent and metastatic nasopharyngeal carcinoma patients after failure of platinum-based chemotherapy.Thirty-nine patients with recurrent and metastatic nasopharyngeal carcinoma who failed previous platinum-based chemotherapy received oral S-1 chemotherapy (twice daily from day 1 to 14) every 3 weeks. The dose of S-1 was determined according to the body surface area (BSA): 40 mg twice a day for BSA <1.25 m(2); 50 mg twice a day for 1.25 m(2) ≤BSA<1.5 m(2); and 60 mg twice a day for BSA ≥1.5 m(2).Treatment was well tolerated. Most adverse events were mild. Grade 3 hematological toxicity occurred in 7.7%. There was one complete response (2.6%) and 12 partial responses (30.7%), giving an overall response rate of 33.3% (95% CI [confidence interval], 21.7-50.8). Median time-to-progression was 5.6 months, and median survival was 13.9 months. One- and 2-year survival rates were 60% and 26%, respectively.S-1 monotherapy is considered a safe and effective treatment option for recurrent and metastatic nasopharyngeal carcinoma patients after failure of platinum-based chemotherapy.
Prediction of Mine Inrush Water Based on BP Neural Network Method

Based on predictions of the mine inflow of water and the complexity of influential factors, a method of BP neural network is put forward for mine inrush water prediction in this paper. We chose proper impact factors and establish non-linear artificial neural network prediction model after analyzed the impact factors of mine water inflow in Shandong Heiwang iron, and also made one prediction with normal mine water inflow during the iron mining operation. It turned out that the result can match with the actual prediction data, which make it possible to predict the mine water inflow with the prediction of Artificial Neural Network.
Corneal endothelial cells provide evidence of accelerated cellular senescence associated with HIV infection: a case-control study

BACKGROUND: Cellular senescence may be a key factor in HIV-related premature biological aging. We assessed features of the corneal endothelium that are known to be associated with biological aging, and cellular senescence markers in HIV-infected adults. METHODS: Case-control study of 242 HIV-infected adults and 249 matched controls. Using specular microscopy, the corneal endothelium was assessed for features of aging (low endothelial cell density [ECD], high variation in cell size, and low hexagonality index). Data were analysed by multivariable regression. CDKN2A expression (a cell senescence mediator) was measured in peripheral blood leukocytes and 8-hydroxy-2'-deoxyguanosine (8-OHDG; an oxidative DNA damage marker) levels were measured in plasma. RESULTS: The median age of both groups was 40 years. Among HIV-infected adults, 88% were receiving antiretroviral therapy (ART); their median CD4 count was 468 cells/µL. HIV infection was associated with increased odds of variation in cell size (OR = 1.67; 95% CI: 1.00-2.78, p = 0.04). Among HIV-infected participants, low ECD was independently associated with current CD4 count <200 cells/µL (OR = 2.77; 95%CI: 1.12-6.81, p = 0.03). In participants on ART with undetectable viral load, CDKN2A expression and 8-OHDG levels were higher in those with accelerated aging, as reflected by lower ECD. CONCLUSIONS: The corneal endothelium shows features consistent with HIV-related accelerated senescence, especially among those with poor immune recovery.
AppRecommender.: Intelligente App-Distribution für optimierte Anwendungsfindung

Als führender Promotor von portugiesischen Aptoide, dem drittgrößten Android App Store weltweit, zielt das AppRecommender-Projekt darauf ab, disruptive intelligente Technologien zu untersuchen und zu entwickeln, um mobile App-Promotoren erfolgreich an ihre Zielkunden zu bringen.
In vitro fertilization(ivf) is a clinical analysis of 18 cases of ectopic pregnancy after embryo transplantation

Objective To investigate the in vitro fertilization(ivf) after an embryo transplantation related risk factors of ectopic pregnancy, the incidence and diagnosis methods. Methods 18 routine in our hospital were retrospectively analyzed in vitro fertilization and embryo transfer(IVF- ET) after ectopic pregnancy patients clinical data,(P0.05). Results From IVF- ET postoperative clinical pregnancies, a total of 541 cases of ectopic pregnancy occurred in 18 cases(3.33%), which occur outside the palace pregnancies 4 cases(7.39%)at the same time,Ectopic pregnancy group of close rate of embryo transfer and tubal factor group obviously higher than that of intrauterine pregnancy. Conclusion IVF- ET is important risk factors of ectopic pregnancy after tubal factor, and the position at the top of the tube and intrauterine transplantation. In IVF- ET postoperative and take corresponding measures in the process of operation, and early diagnosis and treatment can reduce the harm of its produce.
P3-173: HOW SHOULD WE ASSESS FUNCTIONAL PERFORMANCE IN INDIVIDUALS WITH MILD COGNITIVE IMPAIRMENT (MCI)?

Background: The olfactory identificationdysfunction in amnestic mild cognitive impairment (aMCI) which precedes mainly Alzheimer disease (AD) is well known and is considered to be caused by AD pathology. The presence of olfactory impairment in non amnestic MCI (naMCI) and patients with subjective memory complaint (SMC) is controversial. The aim of this study was to examine the degree of objective and subjective olfactory dysfunction in aMCI, naMCI and SMC. Methods: 92 patients with aMCI and 32 patients with naMCI, 28 SMC patients and 50 age matched healthy controls underwent a multiple choice olfactory identification test with 18 different odors developed in our memory clinic. Results: Both aMCI and naMCI patients showed impairment in olfactory identification test compared to both controls and SMC (p<0.01). There was no difference between aMCI and naMCI groups and between SMC and controls in olfactory identification. Conclusions: The olfactory identification impairment in naMCIand aMCI isindistinguishable. NaMCI often converts to Frontotemporal lobar degeneration, dementia with Lewy body or Vascular dementia and the olfactory deficit found in this study could be explained by the recently demonstrated olfactory impairment in these dementia subtypes. SMC patients do not have any significant olfactory discrimination impairment.
Mathematical optimization for clinical decision support and training

Physicians need to make many important decisions per day. One clinical example is the scheduling and dosage of chemotherapy treatments. A second example is the discrimination of atrial fibrillation from atypical atrial flutter, based on ECG data. Such important and complex decisions are usually based on expert knowledge, accumulated throughout the life of a physician and shaped by subjective (and sometimes unconscious) experience. It is not readily transferable and may be unavailable in rural areas. At the same time, the available imaging, laboratory, and basic clinical data is abundant and waits to be used. This data is not yet systematically integrated and often single data-points are used to make therapy decisions. 

More and more clinical decision making tasks will be modeled in terms of mathematical relations. 
I propose a systematic approach that supports and trains individual decision making. The developed ideas, mathematical models, and optimization algorithms will be generic and widely applicable in medicine and beyond, but also exploit specific structures, resulting in a patient- and circumstance-specific personalized medicine.

This allows, e.g., a physician to first simulate the impact of his decisions on a computer and to consider optimized solutions.
In the future, it will be the rare and unwanted exception that an important decision can not be backed up by consultation of a model-driven decision support system or based upon a systematic model-driven training.

MODEST has a mathematical core. It builds on a comprehensive, interdisciplinary work program, based on disciplinary expertise in mixed-integer optimal control and existing collaborations with medical and educational experts. It is both timely, given the increasing availability of data and the maturity of mathematical methods, models, and software; as well as high-impact, due to the large number of clinical areas that may benefit from optimization-based decision support and training tools.
Clinical Importance of Left Atrial Infiltration in Cardiac Transthyretin Amyloidosis

The aim of this study was to characterize left atrial (LA) pathology in explanted hearts with transthyretin amyloid cardiomyopathy (ATTR-CM); LA mechanics using echocardiographic speckle-tracking in a large cohort of patients with ATTR-CM; and to study the association with mortality.The clinical significance of LA involvement in ATTR-CM is of great clinical interest.Congo red staining and immunohistochemistry was performed to assess the presence, type, and extent of amyloid and associated changes in 5 explanted ATTR-CM atria. Echo speckle tracking was used to assess LA reservoir, conduit, contractile function, and stiffness in 906 patients with ATTR-CM (551 wild-type (wt)-ATTR-CM; 93 T60A-ATTR-CM; 241 V122I-ATTR-CM; 21 other).There was extensive ATTR amyloid infiltration in the 5 atria, with loss of normal architecture, vessels remodeling, capillary disruption, and subendocardial fibrosis. Echo speckle tracking in 906 patients with ATTR-CM demonstrated increased atrial stiffness (median [25th-75th quartile] 1.83 [1.15-2.92]) that remained independently associated with prognosis after adjusting for known predictors (lnLA stiff: HR: 1.23; 95% CI: 1.03-1.49; P = 0.029). There was substantial impairment of the 3 phasic functional atrial components (reservoir 8.86% [5.94%-12.97%]; conduit 6.5% [4.53%-9.28%]; contraction function 4.0% [2.29%-6.56%]). Atrial contraction was absent in 22.1% of patients whose electrocardiograms showed sinus rhythm (SR) "atrial electromechanical dissociation" (AEMD). AEMD was associated with poorer prognosis compared with patients with SR and effective mechanical contraction (P = 0.0018). AEMD conferred a similar prognosis to patients in atrial fibrillation.The phenotype of ATTR-CM includes significant infiltration of the atrial walls, with progressive loss of atrial function and increased stiffness, which is a strong independent predictor of mortality. AEMD emerged as a distinctive phenotype identifying patients in SR with poor prognosis.
Multi-Color and single-molecule fluorescence imaging of intraflagellar transport in the phasmid chemosensory cilia of c. elegans

Sensory cilia are essential ‘antenna-like’ organelles that protrude out of many eukaryotic cells, acting as signal transducers, enabling cells to sense and respond to the external environment. The model system for this proposed study, chemosensory cilia of C. elegans are well characterised and enable the animal to sense water soluble effectors in the environment for chemotaxis. Cilia consist of an axoneme encapsulated with a signalling protein-rich ciliary membrane. The axoneme, which is a microtubule-based core structure, acts as a template for a specialised intra-cellular transport, intraflagellar transport (IFT). IFT trains are large protein complexes that mediate contacts between motor proteins (IFT kinesins and IFT dynein) and ciliary cargoes, crucial for the formation and maintenance of the cilia, with anterograde IFT trains moving outwards from the ciliary base to deliver ciliary building blocks to the ciliary tip and retrograde IFT trains moving from the ciliary tip to the ciliary base to recycle the waste products. The overarching objective of this project is to grasp the connection between chemosensory function of cilia (initiating chemotaxis), IFT and ciliary length-regulation using single-molecule imaging techniques. In order to achieve this, (i) I will develop a multi-color and single-molecule imaging toolbox to study IFT in the phasmid chemosensory cilia of C. elegans. (ii) Using the toolbox, I will obtain a mechanistic understanding of turnaround dynamics of the IFT machinery (IFT motors and components of the IFT trains), during normal IFT. (iii) A comprehensive understanding of normal IFT will enable discovery of the subtle adjustments made by the IFT machinery, and its effect on the cilia length, in response to chemical cues in the external environment. Ultimately, the goal is to understand how organism level tactic response is interlinked with intracellular transport in the ciliary antennas of individual cells, using C. elegans as a model system.
PROCESS FOR FORMING A PHOSPHATE CONVERSION COATING

To prevent the deterioration in water-resistant secondary adherence that occurs during prolonged use of a fluoride-containing phosphate conversion coating liquid composition to form a conversion coating on metal surfaces that are at least partly aluminiferous, the aluminum compound-containing sludge produced in the phosphate conversion coating liquid composition as it is used is coagulated and sedimented by adding at least one cationic polymeric coagulant to the sludge-containing phosphate conversion coating liquid composition.
IDF21-0030 More than a third of SACA countries (South and Central America) do not have coverage of insulin, supplies and lab exams

Background: The IDF Diabetes Atlas 2019 points out that SACA is the region with the highest percentage of health expenditures on diabetes, 19.4%. The total number of individuals with diabetes in the region is 31.6 million, which means a prevalence of 9.4%. Countries with the largest percentage of expenditures are Cuba (24.3%), Brazil (24.2%), and Costa Rica (21.3%), while the lowest estimates are for Argentina (5.0%) and Uruguay (6.1%). Aim: Identify if insulin, oral medicines, supplies (syringes, test strips, needles, etc.) and lab exams are fully provided (free of charge) in those countries and if there is an association between percentage of expenditures on diabetes and care provision. Method: A digital online survey with 12 multiple choice questions was shared by e-mail and WhatsApp with all IDF members organizations in the SACA region. It was open for answers between April 4th and May 5th, during the COVID-19 pandemic. The question of interest for this abstract was specifically about access to medicines and lab exams. Mean diabetes-related expenditure (USD) per person with diabetes (20–79 years) was based on IDF Diabetes Atlas 2019 data. Wilcoxon signed-rank test was used to compare expenditures of countries providing free supplies with those without free medical supplies. Results: The questionnaire was answered by 16 of the 18 IDF SACA region countries. Colombia and El Salvador were the only countries with no response. Most of the countries reported free access to oral medicines (69%), insulins (63%), supplies (syringes, needles, test strips, etc. - 56%) and lab exams (63%). Honduras was the only country where free access started because of the COVID-19 pandemic. Associations between expenditures and provision of free oral medicines, insulins, medical supplies or exams were not statistically significant, i.e. free provision of any of the four items was not associated with higher expenditures. Discussion: Our study revealed that expenditure does not determine whether medicines, supplies and exams are provided for free or not. We hypothesize that countries spending less in providing these essential items for free are still spending similar amounts due to the high costs of treating diabetes chronic complications caused by lack of access to insulin, oral medicines, supplies and lab exams. At the same time that most of the SACA countries already count on full coverage of essential diabetes medicines and supplies, such as insulin, metformin, test strips, and exams, there are still 6 countries (Bolivia, Cuba, Dominican Republic, Ecuador, Peru and Puerto Rico) lacking coverage of 3 out of four or of all essential items. It is especially worrisome that 100 years after the discovery of insulin more than a third of the countries in SACA regions still do not count on full provision of this essential life-saving medicine.
La renta básica de ciudadanía y su posible efecto llamada

In the last two decades, there has been a significant number of studies on the proposal of a basic income, but its relationship with the process of contemporary international migration has not been clearly and exhaustively analysed until now. In this article, the authors explore the viability of implementing a basic income of citizenship that could include immigrants with more than one year of residence within the target population. The main objective of this study is to contrast the arguments raised up by the hypothesis of a possible ‘pull effect’ of a basic income. The analysis focuses on the potential behaviour of agents who could be motivated to emigrate by the existence of a basic income in a destination country. The study brings in theoretical arguments and empirical data that question the magnitude and even the existence of a possible pull effect of a basic income, and points up that the proposal is neither a necessary nor a sufficient condition for an increase in migrant population.
Financing renewable energy infrastructures via financial citizen participation – The case of Germany

Abstract Financing decentralized renewable energy infrastructures in Germany is a complex issue due to the fact that public authorities lack the needed capital and institutional private investors are generally averse to restraints such as high transaction costs and risk-return-concerns. Consequently, alternative financing concepts must be developed to keep the energy transition going. An approach that has recently gained attention in Germany is the concept of financial citizen participation. The concept entails that private individuals contribute to the realization of infrastructure projects by investing in renewable energy projects via various business models and financing concepts. This article illustrates empirical results on the relevance of financial citizen participation within the German renewable energy sector, briefly reviews the technical, political and legal framework that led to the significant development in the field of financial citizen participation and analyzes different business models and citizen participation schemes from Germany with a particular focus on so called energy cooperatives and closed-end funds.