SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
The Influence of Fiber Orientation on the Equilibrium Properties of Neutral and Charged Biphasic Tissues

Constitutive models facilitate investigation into load bearing mechanisms of biological tissues and may aid attempts to engineer tissue replacements. In soft tissue models, a commonly made assumption is that collagen fibers can only bear tensile loads. Previous computational studies have demonstrated that radially aligned fibers stiffen a material in unconfined compression most by limiting lateral expansion while vertically aligned fibers buckle under the compressive loads. In this short communication, we show that in conjunction with swelling, these intuitive statements can be violated at small strains. Under such conditions, a tissue with fibers aligned parallel to the direction of load initially provides the greatest resistance to compression. The results are further put into the context of a Benninghoff architecture for articular cartilage. The predictions of this computational study demonstrate the effects of varying fiber orientations and an initial tare strain on the apparent material parameters obtained from unconfined compression tests of charged tissues.
SEGMENTED COLLAPSIBLE BALL SEAT ALLOWING BALL RECOVERY

A series of ball seat assemblies preferably used to open a series of sliding sleeves for formation access to a zone that is to be fractured allows sequential shifting of the sleeves with a single ball. The ball is guided by a tapered member with a lower outlet larger than the ball. The ball lands on the segments that are initially supported. Some leakage occurs between the segments but not enough to prevent pressure buildup to shift the sleeves. The tapered member closely fits to the segments to minimize leakage. Shifting the segments axially allows them to retract so the ball passes to eventually land on a non-leaking seat so that the zone can be fractured. The ball is recovered at the surface after passing the retracted segments and going through the undistorted opening in the tapered member.
Robotic goalie with 3 ms reaction time at 4% CPU load using event-based dynamic vision sensor

Conventional vision-based robotic systems that must operate quickly require high video frame rates and consequently high computational costs. Visual response latencies are lower-bound by the frame period, e.g., 20 ms for 50 Hz frame rate. This paper shows how an asynchronous neuromorphic dynamic vision sensor (DVS) silicon retina is used to build a fast self-calibrating robotic goalie, which offers high update rates and low latency at low CPU load. Independent and asynchronous per pixel illumination change events from the DVS signify moving objects and are used in software to track multiple balls. Motor actions to block the most "threatening" ball are based on measured ball positions and velocities. The goalie also sees its single-axis goalie arm and calibrates the motor output map during idle periods so that it can plan open-loop arm movements to desired visual locations. Blocking capability is about 80% for balls shot from 1 m from the goal even with the fastest-shots, and approaches 100% accuracy when the ball does not beat the limits of the servo motor to move the arm to the necessary position in time. Running with standard USB buses under a standard preemptive multitasking operating system (Windows), the goalie robot achieves median update rates of 550 Hz, with latencies of 2.2 ± 2 ms from ball movement to motor command at a peak CPU load of less than 4%. Practical observations and measurements of USB device latency are provided.
The rise of inter-firm agreements in the Japanese video game industry

The purpose of this paper is to examine inter-firm agreements between small firms and a large well-established firm, focusing on agreements involving complementary products. The well-documented emergence of the Japanese home video game industry is sourced for stylised facts to contribute to literature about the nature of complementary inter-firm agreements. Findings reveal that these agreements between small firms and a large well-established firm can be truly symbiotic, allowing the small firm to build its own reputation and influence the market. Furthermore, the small firm benefits from the user base and core competency of the large firm through economies of scale, and the large firm benefits from the product variety of the small firms through economies of scope. The managerial implications of this paper offer value to both small and large firms in terms of what to look for and how to benefit from inter-firm relationships based on complementary products.
A LEITURA DE LITERATURA INFANTOJUVENIL EM SALA DE AULA: UM RELATO SOBRE FORMAÇÃO DE LEITORES EM UMA TURMA DE 7º ANO

Este trabalho pretende apresentar um relato sobre um projeto de leitura, desenvolvido com uma turma de 7º ano de escola pública municipal em Três Lagoas, MS, a partir da leitura de Reinações de Narizinho, de Monteiro Lobato. Como parte integrante de um curso de especialização, a proposta surgiu diante da observação da realidade sobre a prática e o ensino da leitura de literatura em sala de aula da professora- pesquisadora. A metodologia utilizada foi de cunho qualitativo, e, a partir de entrevistas, foram apurados dados relativos à experiência leitora dos alunos, o que possibilitou um quadro real sobre o desencontro entre o leitor e o texto literário. Os resultados alcançados foram satisfatórios, na medida em que oportunizou aos alunos a leitura da obra lobateana e, principalmente, condicionou uma mudança de postura da professora-pesquisadora sobre sua prática de ensino da leitura de literatura.
Ostomy method and implantation method

The present disclosure relates to an ostomy method and an implantation method. The ostomy method includes steps of making an incision in the chest to expose the heart, puncturing the left ventricle with a puncture needle, thrusting the puncture needle into the ventricular septum and then into the right ventricle to form a puncture site on the ventricular septum, and dilating the puncture site of the ventricular septum with a dilator to form an opening. The method of the present disclosure can reduce the death rate.
Monitoring the Alpine Regions' Sustainability

Development of a database with up to now in this form not developed, yet indicators for monitoring sustainable development of the Alpine Space and all its regions at the NUTS2 level. Analysis of the results as a basis for the formulation of policy recommendation with respect to the promotion of the Alpine Space as a competitive and attractive living and economic space in the scope of a polycentric spatial development. Establishment of an information and communication platform with respect to issues of monitoring and promotion of sustainable development in the Alpine Space and its regions within the projects steering committee and with the presentation and dissemination of the final results of the project with free access for a broad public in the regions of project partners. Broadening and deepening of this platform with the objective of the permanent establishment, further development and update of MARS without help from the ERDF after the termination of the project.
Understanding  circumventing antibiotic resistance

The evolution and spread of antibiotic resistance has become a public health concern of the utmost severity, making once treatable diseases deadly again and undermining our living standards. New therapies are imperative, but equally important are the understanding of the full repertoire of drivers of antibiotic resistance and the identification of ways to counteract them. We have recently established that ~250 non-antibiotic drugs have direct, strong and often broad antibacterial effects on human gut microbes. Moreover, preliminary data indicate that bacteria use similar general resistance mechanisms against both drugs with human targets and antibiotics. This implies that polypharmacy may be a hitherto unnoticed driver of antibiotic resistance. We will use chemical genetics and experimental evolution to systematically map the cross-resistance between human-targeted drugs and antibiotics, and elucidate underlying resistance mechanisms. Using these data, we will next seek to identify antidotes for the antimicrobial side-effects of non-antibiotic drugs, and exploit human-targeted drugs for reverting existing antibiotic resistance. At the genetic level, we will use high-throughput reverse genetics to expose the Achilles heels of bacterial cellular networks for resistance development. Finally, we will uncover the antimicrobial mode of action of tens of human-targeted drugs using thermal proteome profiling and chemical genetics. Together with the genetic information, this line of research will yield design principles and possibly new drug candidates for longer-lived, resistance-proof drug combinations. Overall, this project aims at improving our fundamental biological understanding of antibiotic resistance and the paths to prevent, delay or revert it. It can also set the basis for revisiting current medication policies. The derived principles are likely to be relevant to other diseases and therapies, in which resistance development is an issue.
Swept-source optical coherence tomography imaging of the cortical vitreous and the vitreoretinal interface in proliferative diabetic retinopathy: assessment of vitreoschisis, neovascularisation and the internal limiting membrane

Anomalous posterior vitreous detachment leads to shrinkage of the inner vitreous with the outer precortical vitreous cortex remaining attached to the macula and retina, resulting in vitreoschisis.1 Sebag and coworkers have reported vitreoschisis in macular disorders, and vitreoschisis has been demonstrated using ultrasonography and histopathology.2–⇓4 Swept-source OCT (SS-OCT) is a new imaging technology (Atlantis DRI-OCT-1, Topcon, Japan). We demonstrate for the first time in vivo the microstructural tomographic features of and spatial vitreoretinal relationships between vitreoschisis, retinal and optic nerve head neovascularisation, detachment of the internal limiting membrane (ILM) and traction on the neuroretina in proliferative diabetic retinopathy (PDR).

We identified four diabetic patients with PDR who were previously treated with panretinal laser photocoagulation at Manchester Royal Eye Hospital. Patients had no history of intravitreal antivascular endothelial growth factor or steroid treatment, or previous surgical intervention. All patients were phakic with no other ocular comorbidity. Patients underwent SS-OCT imaging as part of their routine ophthalmic care. The study adhered to the tenets of the Declaration of Helsinki.

SS-OCT imaging showed hyper-reflective fibrovascular neovascularisation elsewhere (NVE) complexes on the retinal surface and adherent to the ILM. Hyper-reflective neovascularisation at the optic disc (NVD) loops and complexes (figure 1A) were shown to extend along the inner aspects of the disc and peripapillary ILM surface. A split within the posterior cortical vitreous was visualised as two distinct hyper-reflective bands (figure 1A). The inner and outer posterior cortical vitreous layers produced similar reflectivity signals with a bilinear appearance on the SS-OCT scans . In another case, with greater antero-posterior vitreous separation, an anomalous split within the posterior cortical vitreous was clearly visible between the NVD and NVE anchorage points on SS-OCT. A detached macular ILM with sub-ILM haemorrhage …
Method and system for spinal cord stimulation prior to and during a medical procedure

A method of performing a medical procedure, such as surgery, is provided. The spinal cord is stimulated in order to control at least one physiological function. The medical procedure is performed and stimulation of the spinal cord is stopped.
Holographic vision for immersive tele-robotic operation

HoviTron - Holographic Vision for Immersive Tele-Robotic OperatioN – develops all hardware and software modules for replacing conventional, stereoscopic Head Mounted Displays (HMD) with a Light Field HMD that provides Holographic Vision with perfect Eye Accommodation and Vergence for ergonomic and Immersive Tele-Robotic Operation. The scene in which the robot operates will be captured by an array of conventional cameras and/or light field cameras to recreate - in real-time - the proper light field in the HMD of the tele-operator steering the robot. The project also aims at evaluating the benefits of such Light Field HMD for the tele-operator, who is expected to experience a more comfortable and less tiring workload than with a conventional, stereoscopic HMD.
Sperm of the wasted mutant are wasted when females utilize the stored sperm in Drosophila melanogaster

Females of many animal species store sperm after copulation for use in fertilization, but the mechanisms controlling sperm storage and utilization are largely unknown. Here we describe a novel male sterile mutation of Drosophila melanogaster, wasted (wst), which shows defects in various processes of sperm utilization. The sperm of wst mutant males are stored like those of wild-type males in the female sperm storage organs, the spermathecae and seminal receptacles, after copulation and are released at each ovulation. However, an average of thirteen times more wst sperm than wild type sperm are released at each ovulation, resulting in rapid loss of sperm stored in seminal receptacles within a few days after copulation. wst sperm can enter eggs efficiently at 5 hr after copulation, but the efficiency of sperm entry decreases significantly by 24 hr after copulation, suggesting that wst sperm lose their ability to enter eggs during storage. Furthermore, wst sperm fail to undergo nuclear decondensation, which prevents the process of fertilization even when sperm enter eggs. Our results indicate that the wst gene is essential for independent processes in the utilization of stored sperm; namely, regulation of sperm release from female storage organs, maintenance of sperm efficiency for entry into eggs, and formation of the male pronucleus in the egg at fertilization.
A critical view on the current application of LCA for new technologies and recommendations for improved practice

LCA is a well-known assessment tool that identifies and provides insights on the environmental impacts of products and services over their lifecycle. The guidance provided by the existing manuals typically applies to modelling and assessing environmental impacts ex-post, meaning that information is available from empirical experience after products have been commercially in use for extended periods of time. This information is not available if LCA is applied in an ex-ante manner before a technology is commercially deployed at scale. We identify the major challenges of applying LCA in an ex-ante manner and propose a route forward in dealing with these challenges that combines intuitions from other disciplinary fields. The first challenge is how to model consistent future foreground systems for the incumbent and new technology systems. Learning curves and scenario approaches are the way forward. The second challenge is how to model future background systems. Here a solution is to transform existing LCI databases towards future contexts, informed by the Integrated Assessment Models (IAMs) that provide scenarios in line with the Shared Socioeconomic Pathways (SSPs). Finally, uncertainty in exante LCA is of a different nature as in ex-post LCAs. The main difference with conventional LCA studies is the highly uncertain information for the future. To acknowledge this. considerate attention should be attributed to the discussion on these uncertainties, both in the design of the assessment and the data used. Responsive evaluation can play a supportive role here. This will increase the transparency and efficacy of the results because the relevant stakeholders and experts are involved. In this way technology designers and other stakeholders derive insights on the influence of design choices or contextual factors (that are important, but hard to influence) on the potential environmental impacts of their foreseen technology. (C) 2020 The Authors. Published by Elsevier Ltd.
Prostate cancer diagnosis and treatment enhancement through the power of big data in europe

Prostate Cancer (PCa) is the second leading cause of cancer, among men in Europe. There are currently major unmet needs in this field, such as insufficient knowledge on risk factors that contribute to PCa and on patient characteristics (including genetic profiles) that could facilitate patient stratification. Finally, there is lack of meaningful engagement of all key stakeholders, while the knowledge currently gained from clinical practice and real life data is not being fed back into PCa patients’ care pathways. There is thus a need for better definition of PCa across all stages, improved patient’s stratification at diagnosis, and standardisation of PCa-related outcomes based on real life data.

PIONEER’s unique dual approach is to first identify critical evidence gaps in PCa by respected Key Opinion Leaders, and then embark on a research priority setting exercise that reflects the needs of all key stakeholders in  PCa management. To achieve this, PIONEER has brought together comprehensive datasets that consists of the most relevant prostate clinical trials and registries, large epidemiological cohorts, electronic heath records, and real-life data from different European (and non-European) patient populations. These unique data sets will be integrated, standardised, harmonised and analysed using approaches that are built on our experience of similar previous IMI projects i.e EMIF, and eTRIKS, and analysed using a unique set of methodologies and advanced analytics methods (OMOP, eHS).  PIONEER has already performed a first PCa research priority setting survey, where major stakeholders were asked to identify the current unmet needs in PCa. The five most important open questions will be used as pilot studies to verify PIONEER’s research framework.  As such, PIONEER’s deliverables will be outcome-driven, value-based and patient-centric, and relevant to all key stakeholders, as they would have been meaningfully involved from the inception of the project.
Emergency doctors exceed their planned hours by 20% or more, survey finds

More than nine out of 10 emergency medicine consultants in the United Kingdom work more than their normal planned hours, a survey by the College of Emergency Medicine has found.

The results are contained in a report, “Stretched to the limit,” which says that there is an urgent need to ensure that safe and sustainable working practices are created in emergency departments.1 It adds that the present situation is unacceptable and makes it more difficult to recruit and retain doctors in emergency medicine.

The college carried out a web based survey of its fellows who are currently consultants, locum consultants, and associate specialists in England, Scotland, Wales, and Northern Ireland. A total of 1077 doctors completed the survey, a response rate of …
Solving resource-constrained project scheduling problem by a genetic local search approach

The resource-constrained project scheduling problem is a general scheduling problem which involving activities need to be scheduled such that the makespan is minimized. However, the RCPSP is confirmed to be an NP-hard combinatorial problem. Restated, it is hard to be solved in a reasonable computational time. Therefore, numerous metaheuristics-based approaches have been developed for finding near-optimal solution for RCPSP. Genetic algorithms have been applied to a wide variety of combinatorial optimization problems and have proved their efficiency. However, prematurely convergence may lead to search stagnation on restricted regions of the search space. To deal with this drawback and beside the good performances attained by local search procedures, a genetic local search algorithm for solving the RCPSP is proposed. Simulation results demonstrate that the proposed GLSA provides an effective and efficient approach for solving RCPSP.
COMPOSITE PLATE AND METHOD FOR THE PRODUCTION THEREOF

The invention relates to a composite plate (2) comprise of a tile (4), a glass plate (8) and preferably of a plastic film which is provided therebetween as a connecting means (6). The inventive composite plate should give rise to, in particular, a so-called glass effect (depth effect).
Analýza data miningových softwarových nástrojů

The main aim of this thesis is to acquaint the reader with available data mining applications using data mining methods. This thesis explains the basic principles of given algorithms and data mining methods. An overview of data mining software tools and their properties is then compiled. This thesis consists of two main parts. The theoretical part explains the concepts of data mining, algorithms and methods of data mining, data warehouses. The reader gets an idea of basic principles and data mining methods. The practical part describes the software used. An overview containing its description, characteristics and the feature comparison from the user's perspective, along with specific practical use examples of given software, is then composed.
OPEN INTERFACE BETWEEN A BASEBAND MODEM AND AN RF UNIT

A method of running a radio equipment, comprising providing a radio equipment having a structure of physically separate modules of a baseband modem and a radio frequency unit including radio frequency control means and radio frequency parts means; and providing a digital interface for the connection of the baseband modem module and the radio frequency unit module with each other within the radio equipment.
“Inverted” zircon and apatite (U–Th)/He dates from the Front Range, Colorado: High-damage zircon as a low-temperature (&lt;50 °C) thermochronometer

Abstract Zircon (U–Th)/He (ZHe) data were acquired for 23 Proterozoic basement samples from an E–W transect through the Colorado Front Range to evaluate whether metamict zircons yield sensible (U–Th)/He data patterns and useful thermal history information. The 112 ZHe dates vary from 147 to 7 Ma, define positive and negative date–eU correlations, and are younger than titanite (U–Th)/He dates that range from 976 to 614 Ma. At moderate to high alpha dose of 10 18 – 10 19 α / g , zircons from the range core yield Laramide ( 52.5 ± 9.6 Ma) dates, whereas those within ∼15 km of the range front yield Miocene ( 21.6 ± 7.7 Ma) results. The He dates for the high alpha dose zircons are reproducible within each sample suite despite their visibly metamict character. The ∼20 Ma range front ZHe dates are younger than apatite (U–Th)/He (AHe) dates ( 66.5 ± 9.6 Ma) and published apatite fission-track data (65–45 Ma) for the same and nearby samples. Thermal history simulations can reproduce the first-order range front date–eU patterns and ZHe–AHe date inversion, but the high-damage zircons are more He retentive than predicted by the zircon damage He kinetic model. The ∼20 Ma ZHe dates may be explained by reheating from hydrothermal fluids along range front faults. The results demonstrate the promise of using He data for high-damage zircons to detect low-temperature (
COLOR-CHANGING FABRIC HAVING PRINTED PATTERN

A color-changing product includes a fabric. The fabric includes a first layer and a second layer. The first layer is arranged using at least one fiber. The at least one fiber includes (a) an electrically conductive core and (b) a coating disposed around and along the electrically conductive core. The second layer is printed onto the first layer. The second layer includes a foreground thermochromic pigment that is selectively activatable by providing an electrical current to the electrically conductive core of the at least one fiber to change at least one of a foreground color or a pattern of the second layer.