SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Structural multiscale modelling of extrusion-based 3d and 4d printed materials

Fused Deposition Modelling (FDM) is a common 3D printing technology based on the extrusion of thermoplastic filaments. While it was initially used only for prototyping, it is nowadays shifting towards manufacturing of mechanical components. 4D printing is a very novel technology to produce smart materials and structures through 3D printing of shape memory materials. Due to the specific process of FDM, the material obtains a characteristic mesostructure, which can be controlled through the print process. It is well known that mechanical properties like strength and toughness of the printed material significantly differ from those of the filament material and that they depend on the mesostructure. However, a real understanding of the material behaviour and the governing phenomena is still missing. The common modelling approach is to consider it as a composite laminate. In this proposal, I show that such models cannot capture the complex behaviour of FDM materials beyond the linear elastic regime. I argue that it can only be understood by considering nonlinear effects at the mesostructure, which needs to be interpreted as a 3D structure of bonded fibres rather than an anisotropic solid. Based on these observations, I will develop a new theoretical and computational framework, where representative volume elements of the mesostructure are modelled as an arrangement of beams with adhesive bonding and are linked to the macroscale through a multiscale approach. To make such computations feasible, it will be necessary to adopt modelling simplifications and a major challenge will be to find the right level of simplification that still can capture the relevant effects. It will also require fundamental development of novel high-order/low-cost numerical methods. The results of the successful project will be a clear understanding of the mechanics of FDM materials as well as tools for the design, analysis, and optimization of FDM structural components.
Value of non-clinical cardiac repolarization assays in supporting the discovery and development of safer medicines

Non-clinical QT-related assays aligned to the pharmaceutical drug discovery and development phases are used in several ways. During the early discovery phases, assays are used for hazard identification and wherever possible for hazard elimination. The data generated enable us to: (i) establish structure-activity relationships and thereby; (ii) influence the medicinal chemistry design and provide tools for effective decision making; and provide structure-activity data for in silico predictive databases; (iii) solve problems earlier; (iv) provide reassurance for compound or project to progress; and (v) refine strategies as scientific and technical knowledge grows. For compounds progressing into pre-clinical development, the 'core battery' QT-related data enable an integrated risk assessment to: (i) fulfil regulatory requirements; (ii) assess the safety and risk-benefit for compound progression to man; (iii) contribute to defining the starting dose during the phase I clinical trials; (iv) influence the design of the phase I clinical trials; (v) identify clinically relevant safety biomarkers; and (vi) contribute to the patient risk management plan. Once a compound progresses into clinical development, QT-related data can be applied in the context of risk management and risk mitigation. The data from 'follow-up' studies can be used to: (i) support regulatory approval; (ii) investigate discrepancies that may have emerged within and/or between non-clinical and clinical data; (iii) understand the mechanism of an undesirable pharmacodynamic effect; (iv) provide reassurance for progression into multiple dosing in humans and/or large-scale clinical trials; and (v) assess drug-drug interactions. Based on emerging data, the integrated risk assessment is then reviewed in this article, and the benefit-risk for compound progression was re-assessed. Project examples are provided to illustrate the impact of non-clinical data to support compound progression throughout the drug discovery and development phases, and regulatory approval.
Taddeo di Bartolo e Rinaldo Brancaccio a Roma: Santa Maria in Trastevere e Santa Maria Maggiore

Taddeo di Bartolo and Rinaldo Brancaccio in Rome: Santa Maria in Trastevere and Santa Maria Maggiore.
The paper reassesses the late career of Taddeo di Bartolo (d. 1422), the most illustrious Sienese painter of the time. By close analysis of a damaged and hardly known fresco formerly in an external tabernacle at Santa Maria in Trastevere, the author argues it to be Taddeo's work about 1420. The attribution confirms, modifies, and expands a tentative suggestion of Serena Romano. The revelation that Taddeo was in Rome substantially reconfigures his last years. A donor portrait and arms indicate that Taddeo's patron was the renowned cardinal and papal diplomat, Rinaldo Brancaccio (d. 1427), known to art historians for his tomb by Donatello and Michelozzo. The author traces the carrers of the painter and the prelate to identify their contact, at Siena in 1407, Pisa in 1409, and Florece about 1419, before Taddeo produced the fresco at Rome. The painting was a precocious effort by one of Martin V's men to renew the desolate Eternal City. Brancaccio's other patronage is examined to reveal that Taddeo formulated a personal, probably votive iconography for the cardinal. Subsequently it was applied in two other Brancaccio painting commissions, and in his marble tomb lunette. The essay also considers the patronage of Masaccio's and Masolino's unususal double-sided polyptych for Santa Maria Maggiore, which is undocumented. Brancaccio has been proposed as its patron, in part because he was archpriest of the great basilica for many years. Recent studies instead point to Antonio Casini, Brancaccio's successor and Taddeo's countryman and bishop, as commissioner. The author reconciles these views by hypothesizing that the notion of a two-sided altarpiece began with Brancaccio. For this enterprise he called Taddeo di Bartolo, veteran painter of a double-face painting at Perugia, to Rome.
FALL PROTECTION SYSTEM

A fall protection system includes a mast assembly including a fixed mast section, a movable mast section, and a winch assembly. The fall protection system further includes a locking mechanism adapted to lock the movable mast section relative to the fixed mast section. The locking mechanism includes a locking pawl connected to the winch assembly. The locking pawl is adapted to rotate between an engaged position and a disengaged position. The locking pawl engages with the fixed mast section in the engaged position to prevent relative movement between the fixed mast section and the movable mast section. The locking mechanism also includes at least one spring adapted to bias the locking pawl towards the engaged position. Further, the winch assembly is adapted to retain the locking pawl in the disengaged position against the biasing of the at least one spring based on a tension selectively applied by the winch assembly.
COMPOSITE COMPOSITION FOR MICROPATTERNED LAYERS

The invention provides a composite composition comprising a cationically polymerizable organic resin, a cationic photoinitiator, a hydrolysate and/or condensate of at least one hydrolysable silane compound and inorganic nanoparticles. The composite composition is suitable for the preparation of patterned moulded articles or substrates having a patterned coating, in particular by photolithography. Micropatterns obtained show improved properties, such as a high shape stability and an excellent elastic modulus.
Fashioning georgian englishness: race, national identity, and codes of proper behaviour

The proposed research project ‘Fashioning Georgian Englishness: Race, National Identity, and Codes of Proper Behaviour’ examines the interconnectedness of nationality, race, and conduct within an eighteenth-century colonial perspective. The interdisciplinary project argues that race played a vital but ambiguous role in the construction of the nascent English national identity in the Georgian era (1714–1830); however, since race was a fluid and heterogeneous concept, the racial and/or national status of English subjects was constructed through the vocabulary and practices of decency, propriety, refinement, and good conduct. Articulations and practices of class- and gender-based ‘proper behaviour’ were thus used to create a naturalised English national character that had a racial foundation.
The project employs an interdisciplinary methodology that combines cultural and intellectual historical methods with constructionist and postcolonial perspectives; through this approach, it examines race and national character as deeply performative, fictive constructions, created through internalising discursive knowledge. The project makes a significant and novel contribution to the history of eighteenth-century English nationalism, which has thus far ignored the importance of race for the construction of a national identity. Moreover, the questions and themes the research addresses also offer a highly fruitful point of comparison to recent processes of cultural interaction and exchange, and the structures of racism and nationalism in present-day Europe.
A comprehensive review of reviews of school-based interventions to improve sexual-health

To systematically review systematic reviews of school-based sexual-health and relationship Education (SHRE) programmes and, thereby, identify interventions and intervention components that promote reductions in risky sexual behaviour among young people.Electronic bibliographies were searched systematically to identify systematic reviews of school-based interventions targeting sexual-health. Results were summarised using a narrative synthesis.Thirty-seven systematic reviews (summarising 224 primary randomised controlled trials) met our inclusion and quality assessment criteria. In general, these reviews analysed distinct sets of primary studies, and no comprehensive review of available primary studies was identified. Interventions were categorised into five types that segment this review literature. Unfortunately, many reviews reported weak and inconsistent evidence of behaviour change. Nonetheless, integration of review findings generated a list of 32 design, content and implementation characteristics that may enhance effectiveness of school-based, sexual-health interventions. Abstinence-only interventions were found to be ineffective in promoting positive changes in sexual behaviour. By contrast, comprehensive interventions, those specifically targeting HIV prevention, and school-based clinics were found to be effective in improving knowledge and changing attitudes, behaviours and health-relevant outcomes.School-based interventions targeting risky sexual behaviour can be effective. Particular design, content and implementation characteristics appear to be associated with greater effectiveness. We recommend consideration of these characteristics by designers of school-based sexual-health interventions.
Introduction to a Special Issue on Molecular Computer Simulations of Clays and Clay–water Interfaces: Recent Progress, Challenges, and Opportunities

Over recent years, a steady increase has been noted in the publication of research articles in Clays and Clay Minerals which have included the use of molecular simulation methods. Based on a keyword search of Web of Science , the number of molecular simulation papers has increased from zero during the first four decades of the journal to five during the late 1990s, to 14 in the 2000s, to 36 so far in the 2010s including those published in this special issue. Most research papers using computational molecular modeling approaches to study the properties of clays and clay-related systems and their practical applications are published in the broader materials science and chemical engineering literature.

The clay-minerals community has taken quite a long time to embrace the technical insights associated with using a molecular modeling approach. Not only does a molecular basis help to develop and test crystallographic models of clay structures, it provides critical insight into understanding the fundamental mechanisms that control many physical and chemical properties, thermodynamics, kinetic processes, and reactivity. Molecular simulations help in the interpretation of spectroscopies and microscopies, and in many other critical issues associated with the behavior and dynamics of clay mineral systems. Though clearly not a panacea for all technical challenges in clay mineralogy, molecular models and simulations provide a solid theoretical context to enable us to delve deeper into the fundamental …
Chiral metamaterials for thz polarisation control

Based on chiral metamaterials and metasurfaces enhanced by graphene and carbon nanotubes, this project aims at providing theoretical basis, performing proof of concept experiments, and building a prototype device for unprecedented dynamic control of THz-wave polarization. The project relies on solid theoretical background that will enable analytical and numerical modelling interaction of the THz radiation with chiral metamaterials and metasurfaces and will also reveal the most promising techniques to control helicity in the THz range by external stimuli. The chiral metamaterials and metasurfaces will be fabricated by advance fabrication techniques including femtosecond micromachining of multilayer substrates, laser sculpturing of the carbon nanotube films and e-beam lithography. The enhancing of the fabricated chiral structures with graphene will provide additional channels for manipulating the helicity-sensitive transmittance and reflectivity, which can be employed for the THz polarization control. The proposed research program implemented via intersectoral and international mobility and connected training, dissemination and outreach activities will enable the knowledge and technology transfer, wider professional networking, acquiring new skills and exploitation of project results by European THz industry. In parallel, the world-wide professional CHARTIST network will considerably enhance the future career prospects of early stage researchers and widen the professional opportunities for experienced researchers involved.
A complete series of halocarbonyl molybdenum PNP pincer complexes – Unexpected differences between NH and NMe spacers

In the present study a complete series of seven-coordinate neutral halocarbonyl Mo(II) complexes of the type [Mo(PNPMe-Ph)(CO)2X2] (X = I, Br, Cl, F), featuring the new PNP pincer ligand N,N'-bis(diphenylphosphino)-N,N'-methyl-2,6-diaminopyridine (PNPMe-Ph), were prepared and fully characterized. The synthesis of these complexes was accomplished by different methodologies depending on the halide ligands. For X = I and Br, [Mo(PNPMe-Ph)(CO)2I2] and [Mo(PNPMe-Ph)(CO)2Br2] were obtained by reacting [Mo(PNPMe-Ph)(CO)3] with stoichiometric amounts of I2 and Br2, respectively. Alternatively, these complexes were obtained upon treatment of [MoX2(CO)3(CH3CN)2] (X = I, Br) with 1 equiv. of PNPMe-Ph. On the other hand, in the case of X = Cl, [Mo(PNPMe-Ph)(CO)2Cl2] was afforded by the reaction of [Mo(CO)4(μ-Cl)Cl]2 with 1 equiv. of PNPMe-Ph. The equivalent procedure also worked for X = Br. Finally, addition of 1 equiv. of 1-fluoro-2,4,6-trimethylpyridinium tetrafluoroborate to [Mo(PNPMe-Ph)(CO)3] yielded the analogous fluorine complex [Mo(PNPMe-Ph)(CO)2F2]. The modification of the ligand scaffold by introducing a Me group instead of H changed the properties of the PNP-Ph ligand significantly. While in the present case exclusively neutral seven-coordinate complexes of the type [Mo(PNPMe-Ph)(CO)2X2] were obtained, with the parent PNP-Ph ligand, i.e., featuring NH spacers, cationic seven-coordinate complexes of the type [Mo(PNP-Ph)(CO)3X]X were afforded. DFT calculations indicated that the reactions are under thermodynamic control. The structures of representative complexes were determined by X-ray single crystal analyses.
CANDITFRUCHT SPA — ORANGE MOON WEB

THE NOTICE AIMS TO FACILITATE INVESTMENTS AIMED AT SUPPORTING THE ACQUISITION OF SKILLS BY COMPANIES THAT ALLOW THE LAUNCH AND CONSOLIDATION OF AN INNOVATION PATH, THROUGH INVESTMENT PROJECTS IN PRODUCT/SERVICE INNOVATION, PROCESS, ORGANISATIONAL AND COMMERCIAL INNOVATION, TO BE IMPLEMENTED ALSO THROUGH NETWORK PROJECTS, THE FINANCING OF COSTS OF PATENTING INNOVATIVE IDEAS, COSTS RELATED TO PROTOTYPING, COSTS RELATED TO THE DEVELOPMENT OF DIGITAL SKILLS.
Dc-Based immunotherapy to treat malignant mesothelioma

Asbestos is one of the major occupational carcinogens. The European Union has an extensive history of protecting workers and consumers against asbestos and even adopted a resolution 2012/2065(INI) ‘on asbestos related occupational health threats and prospects for abolishing all existing asbestos’ last year. Although asbestos is banned, it is still massively present in the built environment. Millions of workers & consumers in the EU were, and still are, for many years exposed to asbestos fibres, despite all measures.

Inhalation of even very low quantities of asbestos fibres tremendously increases the risk of developing Malignant Mesothelioma (MM). The IARC reported 8.100 MM deaths in 2010 in the EU. Despite all EU actions, MM incidence is still increasing. MM is a highly fatal disease with a poor median survival time from first signs of illness to death around 12 months despite aggressive treatments. To date there is no curative therapy for MM. MM is considered as an extremely therapy-resistant disease. Chemotherapy consisting of a combination of pemetrexed and cisplatin is considered standard of care with a median survival increase of 3 months (9-12 months).

The department of pulmonary diseases of the Erasmus MC, Rotterdam, The Netherlands, in collaboration with international partners, have developed a promising personalised immunotherapy for MM with very limited adverse effects. The first clinical results show a considerably prolonged average survival with limited adverse events (24 months, twice as long).

The EMA and the FDA granted this therapy Orphan Designation: autologous dendritic cells pulsed with allogeneic tumour cell lysate for the treatment of malignant mesothelioma (EU: 16 January 2014 - EU/3/13/1229; FDA – US: 06 May 2014).

The objective for the project is to deliver the scientific & registration package for market approval by the EMA of a novel immuno therapeutic approach to treat MM. This includes the execution of a phase II/III clinical trial.
QUality water by Limitation of Actions and Identification of pollutants in ports and the Organization of Transboundary Resources Innovative

This project aims at identifying, reducing and controlling the sources of wastewater drains and pollution in tourist ports inside commercial ports. The latter are especially affected by wastewater pollution discharged into their reservoirs, and all the more so when introduced in urban environments. The above is why the project will at first study and analyse the waters of the partner ports to determine the pollution rate and identify its specific origin. At the same time, existing good practices will be benchmarked, and the relevant stakeholders moved to the ports with the best practices (possibly outside the cross-border areas). Based on the above, the project will define common strategic guidelines for the creation of a concerted action of typical local piloting at each port. It will also involve the various procedures previously indicated to have an impact on water quality. All of this will allow the development of a joint action plan for the reduction and elimination of wastewater. Each partner port will implement a pilot action following the Joint Action Plan and involving the use of 'intelligent' water quality management and information systems, notably a test system. Thea will set up a quality control system of port water to determine the best pilot actions that can be reproduced. The results of the project will be detailed in a document to be disseminated throughout trans-border area ports.
Students’ Perception of Their M-Learning Readiness

The following paper presents the results of a study aimed at achieving a better understanding of the psychological readiness for mobile learning (m-learning) among Saudi students, while also evaluating m-learning readiness as a whole in Saudi Arabia - a topic that has not yet received adequate attention from researchers. Data was acquired via a questionnaire administered to 131 Saudi students at UK universities, in July 2013. The study confirmed that students are confident about using mobile devices in their daily lives, and that they would welcome more opportunities for mobile learning. The findings also indicated that Saudi higher education students are very familiar with, and psychologically ready for, m-learning.
METHOD FOR CALIBRATING A POSITION SENSOR IN A MOTOR VEHICLE GEAR

Method for calibrating a position sensor in a motor vehicle transmission comprising a gear housing with a housing (10) included therein for the position sensor, said sensor housing comprising a pressure member (14) that is held moveably inside the housing (10), said member being pre-stressed elastically against a switch bump and comprising an electric path sensor (38) actuated by the pressure member (14) for measuring the position of the pressure member (14) relative to the housing (10), characterized in that after the housing (10) of the position sensor is installed into the gear housing, at least one calibration measurement is carried out by the path sensor (38) for at least one gear position and for the associated measured value of the path sensor a tolerance zone is defined for each gear position to be detected using the results of the respective calibration measurement.
Elucidating the gene exchange networks of antibiotic resistance genes in clinical sewage microbiomes

Antibiotics are essential for treating bacterial infections. However, antimicrobial resistance (AMR) has spread among pathogenic bacteria, leading to therapy failure or deaths of patients. Due to their association with promiscuous mobile genetic elements, clinically important antibiotic resistance genes (ARGs) can spread rapidly among diverse bacteria through horizontal gene transfer (HGT). Due to HGT, identifying the microbial hosts of the ARGs in an ecosystem is a challenge. Importantly, it has been shown that ARGS can spread from human gut commensals to clinical pathogens and vice versa. 

Wastewater from clinical sources can importantly select for HGT of ARGs between different microbes, as both antibiotics and ARGs are present at high levels. The aim of this project - ""ARCS"" (Antibiotic Resistance in Clinical Sewage microbiomes), is to reveal the ARGs exchange networks in clinical sewage microbiomes. The research objectives are: 1) Link ARGs to microbial hosts by using novel culture-independent methods based on DNA high-throughput sequencing. 2) Link ARGs to mobile genetic elements by isolating, sequencing, and characterizing the genomes of the identified hosts of ARGs. 3) Evaluate whether the isolates can transfer their ARGs to clinical pathogens using conjugation assays. ARGS will thus lead to a step-change in our understanding of HGT of ARGs in complex microbial ecosystems. 

The Fellow Dr. Lisandra Zepeda's expertise in generating and analysing DNA sequencing data and the host Prof. Willem van Schaik's international leadership in AMR ensure a successful completion of ARCS and a favourable knowledge transfer for both parties. Furthermore, the supportive environment of the University of Birmingham ensures the accomplishment of the Fellow's training in crucial areas such as microbial DNA capture sequencing, microbiology laboratory techniques, and mentoring skills. Thus, ARCS will enable Dr. Zepeda to realise her career goal of becoming a research group leader.