SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Aumentare la competitività e il potenziale di innovazione del laboratorio cosmetico AVA Larysa Dysput — Goławska attraverso l'attuazione di attività di investimento sotto forma di acquisto di attrezzature, macchine e attrezzature di tecnologia di produzione per implementare in modo innovativo, funzionalmente e funzionalmente, la linea di prodotti cosmetici — bio Alga; olivello spinoso bio; Pelle b

L'obiettivo del progetto è quello di aumentare la competitività e lo sviluppo del potenziale di innovazione del laboratorio cosmetico AVA Larysa Dysput — Goławska attraverso la realizzazione di attività di investimento, che porteranno all'introduzione sul mercato di cinque (5) linee di prodotti cosmetici funzionali e utilizzabili significativamente migliorate e all'ammodernamento tecnologico delle infrastrutture dell'azienda. Il progetto prevede l'implementazione dell'innovazione di prodotto e di processo. L'implementazione dell'Investimenti comporterà lo sviluppo sostenibile dell'azienda, aumenterà la scala operativa dell'azienda e aumenterà significativamente la portata di mercato dell'offerta e aumenterà l'occupazione. L'obiettivo principale sarà raggiunto attraverso il conseguimento di obiettivi specifici, tra cui: il lancio di cinque (5) linee di prodotti cosmetici notevolmente migliorate (innovazione di prodotto) — bio Alga; olivello spinoso bio; Pelle bianca; per capillari estesi; Acne anti-acne (nella composizione di ogni linea comprenderà, tra gli altri: creme funzionali giorno/notte, crema da giorno, crema notte, crema occhi, siero e tonico); ammodernamento tecnologico dell'infrastruttura aziendale; razionalizzare e modernizzare il processo di produzione e distribuzione dei prodotti (innovazione di processo); un aumento significativo delle entrate dell'azienda; rafforzare la posizione del mercato e rafforzare la stabilità economica e finanziaria; espansione nei mercati nazionali ed esteri e acquisizione di nuovi punti vendita (controparti). Il progetto prevede l'implementazione dei risultati dei propri lavori di R & S, che si traducono in innovazioni di prodotto. Il progetto assume solo l'uso di soluzioni pro-ecologiche e l'utilizzo della tecnologia acquistata per sostenere la formazione pratica di giovani e adulti. Il progetto rientra pienamente nell'obiettivo principale del POR WM 2014-2020, nell'ambito dell'asse prioritario III Sviluppo del potenziale innovativo e dell'imprenditorialità; privato dell'obiettivo specifico 3: Maggiore ricorso all'innovazione nelle PMI. Il progetto implementa una specializzazione intelligente regionale.
Hyponatremia and In-Hospital Mortality in Patients Admitted for Heart Failure (from the ATTEND Registry)

Hyponatremia is known to be a poor prognostic factor in patients hospitalized with heart failure (HF), however not well studied in Japan. The aims of this study were to characterize hyponatremic hospitalized patients with HF and to clarify the relations between hyponatremia and detailed in-hospital outcomes in Japan. Among 4,837 hospitalized patients with HF enrolled in the Acute Decompensated Heart Failure Syndromes (ATTEND) registry, patient characteristics and in-hospital mortality in those with hyponatremia were examined. Hyponatremia (sodium <135 mEq/L) was observed in 11.6% of patients. Patients with hyponatremia were of similar age, included fewer men, and had a higher proportion of previous hospitalizations for HF compared to those with normonatremia. On admission, lower heart rates and blood pressures and higher brain natriuretic peptide levels were observed in patients with hyponatremia. During hospitalization, inotrope levels and mechanical device use were significantly higher in patients with hyponatremia. Rates of all-cause and cardiac death were significantly higher in patients with hyponatremia, 15.0% and 11.4%, respectively, compared to 5.3% and 3.6%, respectively, in those with normonatremia. In hyponatremic hospitalized patients with HF, cardiac death accounted for 76.2% of all-cause death. In conclusion, the present study demonstrates that in Japan hyponatremia in patients hospitalized with HF is relatively common and is associated with a very high in-hospital mortality.
DEVICE AND METHOD FOR CONTINUOUSLY AND NON-DESTRUCTIVELY MONITORING VARIATION IN THE THICKNESS OF SHAPED SECTIONS.

Dispositif de mesure et/ou de contrôle non destructif et continu de l'épaisseur d'un profilé comportant en combinaison: a) au moins un moyen (2) destiné à créer une variation de température dudit profilé, b) au moins un moyen (3) de détection et de mesure du rayonnement émis par ledit profilé au cours du transitoire thermique et c) au moins un moyen (4) permettant audit moyen de détection et de mesure du rayonnement émis de balayer toute la surface du profilé. Ledit moyen de détection et de mesure est relié à un système informatique (5) comprenant un logiciel de traitement d'images, un moyen d'enregistrement du rayonnement émis et un écran de visualisation (6).
Multisensor sorting tools in a circular economy approach for the efficient recycling of pvb interlayer material in high-quality products from laminated glass construction and demolition wastes

Laminated glass is obtained by bonding glass layers using a polymeric interlayer. Polyvinyl Butyral (PVB) is used as interlayer in laminated glass and their use in construction components is growing, therefore the end-of-life should be addressed. In EU, glass waste from Renovation and Demolition are quantified on 1.540.704 tons/year. The proper recycling of all building glass waste could avoid 925.000 tons of landfilled waste every year. Up to now, most of the post-consume PVB material in laminated glass is incinerated/landfilled, and only a 9 % is recycled in secondary uses. Recycling of PVB present several difficulties related with the contents of glass, humidity, mixing of compositions and polymer optical degradation which impede reusing as interlayer. SUNRISE will demonstrate within the current glass recycling business the application of an innovative optical multi-sensor sorting tool based on industrial in-line techniques (Raman, IRS, Fluorescence and Optical Spectroscopy) and AI algorithms which will allow optimal classification of laminated glass according to composition and degradation.  Therefore, allowing the tailored mechano-chemical treatment for purification which will enable the post-consume PVB recycling and reusing as interlayer film. In order to ensure the success, the project counts with glass recycling associations and companies and main actors in mechano-chemical treatment of PVB and optical in-line systems. Industrials partners will validate the suitability of the final products in a market environment.  Other transdisciplinary aspects will be incorporated including modelling, health, safety and environmental issues, dissemination & exploitation and standardisation.  The success of SUNRISE will increase the European market in 360 million €/year by the proper collection and recycling of 1.250.352 tons/year of laminated glass, which will avoid PVB wastes of more than 125.000 tons, representing benefits at economic, environmental and social level.
Abstract A23: Noxa determines localization and stability of MCL-1 and consequently ABT-737 sensitivity in small cell lung cancer.

Small cell lung cancer (SCLC) accounts for approximately 15% of lung cancers diagnosed in the US and causes a fatality rate of more than 90%. Over the past 25 years, progress has been made in limited stage SCLC, where the combination of concurrent radiation and chemotherapy has resulted in a long term survival rate of 20-25%. However, progress has been slow in extensive SCLC (70% of all cases), with long term survival rates of approximately 3% when treated with a variety of multi-agent chemotherapy regimens. Tumor cell death induced by chemotherapy or lack of appropriate cellular survival signals is mediated by the intrinsic apoptotic pathway. We and others have demonstrated that the anti-apoptotic member BCL-2, as well as BCL-XL and MCL-1, is overexpressed in SCLC. However, until recently, the precise role of these proteins in SCLC biology and therapeutic resistance was poorly understood. The breakthrough came with the development of BH3 mimetic antagonists that block the function of pro-survival BCL-2 family members. ABT-737, the prototype of this new drug class, binds to and blocks BCL-2 and BCL-XL, but not MCL-1 function. Surprisingly, the sensitivity to ABT-737 varies in a broad range in SCLC cells. We have previously shown that the expression of Noxa, a BH3-only pro-apoptotic BCL-2 family protein, is the critical determinant of ABT-737 sensitivity. We show here that Noxa regulates the localization and stability of MCL-1, an anti-apoptotic member, which results in modulating ABT-737 sensitivity. Mutations in Noxa within either the BH3 domain, the carboxyl terminus mitochondrial targeting domain, or of ubiquitinated lysines not only change the localization and stability of Noxa itself, but also affect the mitochondrial localization and phosphorylation/ubiquitination status of MCL-1 and consequently modulate sensitivity to ABT-737. Results of studies utilizing these mutant proteins indicate that Noxa recruits MCL-1 from the cytosol to the mitochondria. Translocation of MCL-1 initiates its phosphorylation and subsequent ubiquitination, which triggers proteasome-mediated degradation. The precise regulatory mechanisms of Noxa/MCL-1 expression and stability could provide alternative targets to modulate apoptosis induced by BH3 mimetic drugs or other chemotherapeutic reagents. Citation Format: Wataru Nakajima, Mark A. Hicks, Nobuyuki Tanaka, Geoffrey W. Krystal, Hisashi Harada. Noxa determines localization and stability of MCL-1 and consequently ABT-737 sensitivity in small cell lung cancer. [abstract]. In: Proceedings of the AACR-IASLC Joint Conference on Molecular Origins of Lung Cancer; 2014 Jan 6-9; San Diego, CA. Philadelphia (PA): AACR; Clin Cancer Res 2014;20(2Suppl):Abstract nr A23.
Software Copy Protection and Licensing based on XrML and PKCS#11

This paper proposes Software Copy Protection and Licensing techniques based on Xrml and PKCS#11 standards. The purpose of the techniques is to increase the strength of software copy protection and preventing illegal distribution of software, which in turn protects intellectual property and secures the financial benefits for the vendors. The paper proposes a flexible, readable yet secure license structure based on Xrml. The licensing system is combined with two different protection techniques, Protection using Smart Tokens and Protection using Internet Activation Server. The paper illustrates how to map the license structure to grant records used in protection and Rights Management using PKCS standard. Finally, the paper proposes a full system architecture providing different licensing schemes useful in software market.
Mirna biomarkers of osseous metastases in serum from breast cancer patients

Bone metastasis is a common complication for breast cancer patients, affecting 70% of patients diagnosed at advanced stages. Blood-based microRNAs (miRNAs) have received considerable research interest as biomarkers in cancer. The identification of biomarkers predictive of bone metastasis may be useful for the administration of preventative drugs such as bisphosphonates. In this study, a large-scale screening analysis of > 700 miRNAs will be performed in serum from breast cancer patients with and without visceral or bone metastasis. We will further evaluate candidate miRNAs using serum samples from a second cohort of breast cancer patients who were examined prospectively (with 8 years of follow-up) for relapses in bone and non-bone sites. At this stage, we anticipate the identification of a miRNA signature predictive of bone metastasis in patients with early-stage breast cancer. The second part of this study will assess the role of these miRNAs in the tumour-bone microenvironment. Circulating miRNAs may derive from bone cells or the tumour, and may enter the circulation through cell-derived vesicles called exosomes. We will study the biological functions of miRNAs dysregulated in patient serum. Overlaps between miRNAs in the serum and exosomal miRNAs that are derived from tumour cells or osteoclasts will be further assessed using in vitro and in vivo models of bone metastasis. By studying the activities of these exosomal miRNAs in the bone microenvironment, we may be able to better understand bone metastasis as well as identify new miRNA-based therapeutic targets.
Father trials: hormonal and behavioral experiments on prenatal and postnatal parenting

Fathers have largely been neglected in parenting research -- although they constitute about 50% of parents. The aim of the proposed project is to test the hypothesis that fathers’ parenting is under hormonal control and can be changed by behavioral and hormonal interventions. I propose a series of randomized controlled trials (RCT) focusing on a critical phase of parenthood: the transition to having the first baby. I will test whether experiments that modulate oxytocin and testosterone levels enhance fathers’ neural processing of infant signals and of threats to the infant and stimulate fathers’ parenting quality and involvement in parenting. 

Drawing firm conclusions about the neural and hormonal basis of human parenting is critically dependent on RCTs. I propose two types of experiments: (1) within-subject trials, using nasal administration of oxytocin, testosterone, and a placebo, and (2) between-subject trials, using behavioral interventions aimed at promoting sensitive parenting and physical contact. The behavioral interventions include prenatal and postnatal video feedback intervention (in the prenatal phase based on ultrasound scans) and the use of soft baby carriers. Both types of trials take place 3 months before the infant’s birth, and 2 and 7 months afterwards.

A special focus lies on the aspect of protection: a dimension of parenting that has received considerable attention in animal research but, despite its evolutionary importance, not in studies on humans. Testing the efficacy of the behavioral experiments in boosting fathers’ protective parenting and participation in caregiving activities has clear practical significance (for fathers, mothers, children, and society). At the same time, examining the hormonal and neural mechanisms is crucial for the development of theory on the interplay between neuroscience and parenting.
Endoplasmic reticulum structure and synaptic function in drosophila

In neurons, endoplasmic reticulum (ER) organelle shows physical continuity between dendrites, cell body and axonal presynaptic terminals, and has been termed “a neuron within a neuron”. The importance of ER in axons is suggested by the fact that mutations of ER-shaping proteins result in hereditary spastic paraplegia (HSP), a motor axon degeneration disease. ER is present in presynapses, and mutations of ER-shaping proteins disrupt synaptic morphology or function. However, the physiological roles of ER distribution in this context are largely unknown.

The time to study the roles of ER distribution in presynaptic terminals is opportune: new HSP-associated genes encoding ER proteins are being identified continuously in human patients; studies in non-neuronal cells identified several HSP-gene-encoded proteins as ER-shaping proteins - to date these have not been examined in synapses; there is increasing data about the nature and roles of contact sites between ER and other cellular structures, whose functions are required at synapses. Drosophila is a successfully used model for neuronal cell biology and degeneration, which reduces use of regulated vertebrates; my sponsor has developed tools to detect impaired neuronal ER organisation in Drosophila; and emerging microscopy techniques allow ultrastructural analysis and 3D reconstruction of the ER network.

My work will specifically examine the distribution and role of ER at presynaptic level for the first time, and mechanisms of dysfunction that are relevant for human neurodegenerative diseases. I will study neuromuscular junctions in wild-type and in Drosophila mutants for HSP ER-shaping proteins, to understand the roles of these proteins and the consequences of any altered distribution for local trafficking and organelle function. To address this aim, I will use electron and super-resolution microscopy, and using light microscopy markers I will undertake structural and functional characterization of ER distribution.
PLASTIC SINGLE-USE REDUCTION ECO-SUSTAINABLE

BIOPOLYMERS ARE GRADUALLY ENTERING INTO ALL INDUSTRIAL SECTORS AND EVERYDAY LIFE, WITH THE AIM OF CREATING NEW CIRCULAR ECONOMY MODELS AND REDUCING THE ENVIRONMENTAL IMPACT RELATED TO THE PRODUCTION AND USE OF PETROLEUM-DERIVED POLYMERS. A POTENTIAL SCOPE OF APPLICATION OF BIOPOLYMERS IS THAT OF PACKAGING. IN PARTICULAR, CAPSULES TO COVER THE NECK OF WINE BOTTLES THAT HAVE A VOLUME OF ABOUT 14 BILLION UNITS PER YEAR. PURE WANTS THE REPLACEMENT OF PLASTIC MATERIALS WITH MATERIALS OF BIOLOGICAL ORIGIN AND MORE ENVIRONMENTALLY SUSTAINABLE, WITH THE AIM TO REDUCE THE POLLUTION GENERATED BY THE DISPERSION IN THE ENVIRONMENT OF CAPSULES AND TO REDUCE THE RISKS OF THE WORKERS WHO PRODUCE THEM FOLLOWING THE ELIMINATION OF SOLVENTS USED IN THE CURRENT PRODUCTION PROCESSES. PURE IS THEREFORE PART OF THE S3 SPECIALISATION AREA OF ADVANCED MANUFACTURING, AND CONCERNS THE STUDY OF ALTERNATIVE MATERIALS FOR THE PRODUCTION OF C CAPSULES
Phrase-Based Translation Model for Question Retrieval in Community Question Answer Archives

Community-based question answer (Q&A) has become an important issue due to the popularity of Q&A archives on the web. This paper is concerned with the problem of question retrieval. Question retrieval in Q&A archives aims to find historical questions that are semantically equivalent or relevant to the queried questions. In this paper, we propose a novel phrase-based translation model for question retrieval. Compared to the traditional word-based translation models, the phrase-based translation model is more effective because it captures contextual information in modeling the translation of phrases as a whole, rather than translating single words in isolation. Experiments conducted on real Q&A data demonstrate that our proposed phrase-based translation model significantly outperforms the state-of-the-art word-based translation model.
Computational investigation on a series of heteroaromatic nitrogen-rich compounds

Density functional theory calculations were performed to calculate the detonation performance, frontier molecular orbitals, and impact sensitivity of a series of heteroaromatic nitro-rich compounds. The results show that all the title compounds exhibit high-positive solid-phase heats of formation. The detonation velocities and pressures of the title compounds were predicted via the Kamlet–Jacobs equation. Thirteen compounds have larger D and P than HMX because of the big crystal densities and solid HOFs. The analysis of frontier molecular orbitals shows that two compounds may be kinetically more stable and chemically less active than other compounds. In addition, most of the compounds were found to have lower impact sensitivity than HMX.
TUBING CONNECTOR

A tubing connector non-releasably connected to a tube of tubing string for u se downhole in oil and gas well operations, the connector comprising connector body (1) wit h an end portion fitted concentrically within or over a corresponding end of the tube (2), the end portion having a plurality of depressions (12) coinciding with corresponding depressions (10) on the corresponding end of the tube (2) whereby the connector body (1) and tube (2) are connected together, the depressions (10) and the tube (2) having been formed by localised plastic deformation of the walls of the tube (2).
Quantifying atmospheric ice nucleating particle (inp) concentrations via advances in measurement techniques and field studies of ice nucleation

The focal point of the research proposal is to combine the current technological advancement and scientific questions regarding the unknowns of atmospheric ice nucleation. Ice nucleation is an important pathway for cloud formation and initiation of precipitation, therefore playing a significant role in the Earth’s hydrological cycle and energy and radiative balance. Several questions pertinent to ice nucleation remain unanswered, partially due to gaps in instrumental technology and lack of ambient measurements. The proposed work primarily focuses on the mechanisms of ice nucleation in the atmosphere, more specifically the number, physics and chemistry of biogenic and anthropogenic aerosol particles able to act as ice nucleating particles (INP). Field measurements with technological improvements to the existing Portable Ice Nucleation Chamber (PINC) are planned. One of the goals is to continue the time series measurements of INP parameters at the Izaña Observatory in Tenerife, where measurements have been ongoing since 2013 by the host institution.  Since the INP concentration exponentially decreases with increasing temperature, and it is the warmer sub-zero temperatures that are more relevant for the initial ice formation in mixed-phase, the goal is to extend the measurements of INP parameters at the Izaña Observatory in Tenerife to temperatures above −30°C. Using additional instrumentation in the field, the role of mineral dust, particles of anthropogenic origin and marine primary biogenic particles as potential INP will be investigated in more detail. From a technical perspective, the work will concentrate on lowering the detection limits of PINC and on improving its ability to differentiate between water droplets and ice crystals. These improvements will allow measuring INP at warmer sub-zero temperatures and in immersion/condensation mode, both of which are more relevant for the first ice formation in supercooled clouds than our current measurements.
Imaging recognition events between human IgG and rat anti-human IgG by atomic force microscopy

Chemically immobilized rat anti-human immunoglobulin (IgG) monolayers on thiols modified gold substrates were fabricated using self-assembled monolayer (SAM) method. The antibody monolayers were imaged before and after free human IgG treated, whilst recognition events between antigen and antibody were monitored by contact mode atomic force microscopy (CM-AFM) and tapping mode AFM (TM-AFM), with topographic and/or phase images being recorded. The obtained images with different surface compositions show distinct nanostructures, indicating occurrence of recognition and binding events of antigen-antibody. The size of the observed surface structures of the antibody monolayer, when tip broaden effect had been taken into account, was very close to the actual size of the antibody molecule. Thus, these results suggest CM-AFM is capable of, and proven satisfactory in detecting protein-protein interactions (PPIs), providing the sample was prepared appropriately and the scanning parameters were set adequately. Moreover, phase imaging can serve as a real time contrast enhancement technique to TM-AFM in terms of highlighting edges and clearly observing fine features.
PHENOL FREE STABILIZATION OF POLYETHYLENE.

This invention provides a process for the stabilization of thermoplastic polyolefins during melt processing operations. The stabilizer package of this invention is "phenol free" and must contain at least two selected phosphite stabilizers. The process of this invention is especially suitable for the manufacture of polyethylene film.