SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Functional dissection of x-linked regulatory dna: unravelling the impact of genome topology on transcriptional regulation

Mammalian genomes are structurally organized into sub-chromosomal self-interacting domains called topologically associating domains (TADs). Functionally, genes embedded within the same TAD appear to be co-regulated by their shared regulatory landscapes, suggesting the tendency of the genome to be divided into discrete regulatory domains. Although disrupting TAD boundaries has been shown to result in aberrant patterns of gene expression, whether TAD organisation is cause or consequence of transcriptional activity remains largely unknown, as well as the regulatory elements that direct TAD formation and long-range chromatin interactions within TADs. This project aims to define the exact functional link between genome topology and transcriptional regulation by exploiting the mammalian dosage compensation mechanism X-Chromosome Inactivation (XCI) as a model system. First, I will identify the combination of regulatory elements that allow a subset of X-linked genes to resist the transcriptional silencing of one entire X chromosome in female cells. Then, I will characterise their functional and structural relevance by combining advanced epigenetic tools for the manipulation of complex regulatory networks with transcriptomic analysis and chromosome conformation capture, an innovative method that allows to define the 3D structure of chromosomes within the nucleus. This project represents a unique opportunity to enhance our understanding of genome topology, providing valuable insights into the roles of the non-coding genome in gene regulation. Considering my personal professional background, and the outstanding level of scientific excellence of the host institution, this project promises a great potential of radically advancing the field and, in addition, will provide the European Research Area with a highly-qualified expert scientist who has the technical and complementary skills to successfully lead a European research team.
AUTONOMOUS FARM EQUIPMENT HITCHING TO A TRACTOR

A method for autonomously maneuvering a tractor in reverse for attachment to a trailer using a hitch assist system, the method including: entering a hitch assist mode, displaying a camera image on a user interface, and receiving an indication of a selected trailer. The method also includes determining a planned path with a computing device a tractor path from an initial position to a final position adjacent the trailer, the tractor path including maneuvers configured to move the tractor along the tractor path from the initial position to the final position. The method also includes autonomously following, at a drive system in communication with the computing device, the tractor path from the initial position to the final position.
Craniofacial morphology characteristics of operated unilateral complete cleft lip and palate patients in mixed dentition

The objective of this study was to analyze craniofacial morphologic characteristics at the stage of mixed dentition in Chinese children who had received surgery for unilateral complete cleft lip and palate (UCCLP) compared with the healthy population.Lateral cephalometric radiographs were taken for 2 groups of individuals: (1) 48 UCCLP patients who had been operated on before 2 years of age, and (2) 60 noncleft peers as controls.The operated UCCLP groups differed from the control group as follows: reduced cranial base length, less maxillary length, more retrognathic maxilla, retusion of the entire maxilla, more incongruous intermaxillary relation, more concave skeletal profile, and more lingually inclined maxillary and mandibular incisors.The operated UCCLP children at the mixed dentition stage showed serious craniofacial deformities and the craniofacial growth was influenced (especially in maxilla).
Continuous flow reactor for hierarchically designed nanocomposites

Since the release of the first lithium ion battery in 1991, this technology has been growing continuously and has been pivotal in enabling new technologies ranging from consumer electronic devices to electric vehicles (EVs). However, the currently used intercalation-based electrode materials are approaching their theoretical capacities, and are falling short of the requirements for future EV applications. This project seeks to address some of these issues by developing a new electrode formulation. Conversion materials with high reversible capacities are particularly promising candidates to improve the energy and power density of batteries, but they suffer from poor electrical conductivities. Current research seeks to address these issues by mixing these materials with highly conductive additives such as graphene and carbon nanotubes (CNTs). However, these solutions often suffer from poor interfaces between the conductive additive and the active material, or are difficult to produce at scale.
 In this Marie SkŁodowska-Curie Fellowship, a radically new method to mass produce advanced conversion materials will be developed using a continuous flow reactor. In this approach, CNTs are grafted directly on the surface of conversion materials. Because of how the CNTs are synthesized on the active material, they form an excellent interface, which is key to enhance the electrical conductivity of the electrodes. Further, this project will also engineer the conversion material itself (composition, porosity, and size) to improve ion diffusion and thus the power density of the batteries. Because of these unique performance features and the capability to fabricate these materials at large scale using a continuous flow process, we anticipate that this project will be attractive to both academic and industrial researchers. Therefore, this project will address the growing need for better batteries to support the European automotive industry in its development of electrical vehicles.
ETCHING OF SUBSTRATES OF LIGHT EMITTING DEVICES

Fabrication of a light emitting device includes etching of a substrate of the light emitting device. The etch may be an aqueous etch sufficient to increase an amount of light extracted through the substrate. The etch may be a direct aqueous etch of a silicon carbide substrate. The etch may remove damage from the substrate that results from other processing of the substrate, such as damage from sawing the substrate. The etch may remove an amorphous region of silicon carbide in the substrate.
Data Cube Computational Model with Hadoop MapReduce

XML has become a widely used and well structured data format for digital document handling and message transmission. To find useful knowledge in XML data, data warehouse and OLAP applications aimed at providing supports for decision making should be developed. Apache Hadoop is an open source cloud computing framework that provides a distributed file system for large scale data processing. In this paper, we discuss an XML data cube model which offers us the complete views to observe XML data, and present a basic algorithm to implement its building process on Hadoop. To improve the efficiency, an optimized algorithm more suitable for this kind of XML data is also proposed. The experimental results given in the paper prove the effectiveness of our optimization strategies.
A spatial filter-enabled high-resolution subgridding scheme for stable FDTD modeling of multiscale geometries

As many real-life microwave structures include multiple space and time scales, research on stable subgridding schemes is as timely as ever. This paper presents a new approach to this old problem, within the context of the FDTD technique, based on a spatial filtering method that enables dense and coarse grids to be run at the time-step of the coarse grid. A spatial filter, coupled to the FDTD update equations, stabilizes those subgrids that are simulated at time steps above their stability limit. The proposed method is used to implement very high aspect ratio subgrids, maintaining late-time stability over millions of time steps.
IMPROVED SPINDLE LINER COMPONENT FOR TURNING MACHINES

A work-piece support member forming part of a spindle liner for use within the hollow spindle of a turning machine comprising: a disc dimensioned to fit closely within the hollow spindle, having a central aperture (A) sized to accept a work-piece; holding at least one helical spring (20) positioned adjacent to the aperture (A); such that in use the axis of said spring is held perpendicular to the axis of said work-piece such that part of the side walls of said spring or springs (20) abut against said work-piece and thereby firmly support said work-piece as it rotates with the hollow spindle about the axis of said hollow spindle.
From irreducible representations to locally decodable codes

A q-query Locally Decodable Code (LDC) is an error-correcting code that allows to read any particular symbol of the message by reading only q symbols of the codeword even if the codeword is adversary corrupted. In this paper we present a new approach for the construction of LDCs. We show that if there exists an irreducible representation (ρ, V) of G and q elements g1,g2,..., gq in G such that there exists a linear combination of matrices ρ(gi) that is of rank one, then we can construct a q-query Locally Decodable Code C:V-> FG. We show the potential of this approach by constructing constant query LDCs of sub-exponential length matching the best known constructions.
Impact of dust radiative forcing in snow on accuracy of operational runoff prediction in the Upper Colorado River Basin

[1] Accurate prediction of snowmelt runoff is critical in the US Intermountain West, where water demand is increasing and snow patterns are shifting. Here, we show that errors in the National Weather Service Colorado Basin River Forecast Center's operational streamflow predictions are correlated with the interannual variability of dust radiative forcing in snow. With data from 2000–2010, we show that errors in snowmelt period streamflow prediction for the southern Colorado Rockies are linearly related to melt period dust radiative forcing in snow as inferred from NASA Moderate Resolution Imaging Spectroradiometer data, which ranged interannually from 20 to 80 W m−2. Each 10 W m−2 change of melt period dust forcing resulted in a corresponding change in runoff prediction bias of 10.0% ± 1.5% and a 1.5 ± 0.6 day shift in runoff center of mass. Accounting for bias introduced by dust forcing could improve streamflow prediction in regions prone to dust deposition in the snowpack.
Effects of tannin-rich host plants on the infection and establishment of the entomopathogenic nematode Heterorhabditis bacteriophora

Parasitized animals can self-medicate. As ingested plant phenolics, mainly tannins, reduce strongyle nematode infections in mammalian herbivores. We investigated the effect of plant extracts known to be anthelmintic in vertebrate herbivores on the recovery of the parasitic entomopathogenic nematode Heterorhabditis bacteriophora infecting African cotton leafworm (Spodoptera littoralis). Nematode infective juveniles (IJs) were exposed to 0, 300, 900, 1200, 2400 ppm of Pistacia lentiscus L. (lentisk), Inula viscosa L. (strong-smelling inula), Quercus calliprinos Decne. (common oak) and Ceratonia siliqua L. (carob) extracts on growth medium (in vitro assay). In control treatments, 50-80% of IJs resumed development to J4, young and developed adult hermaphrodites, whereas all extracts, except for C. siliqua at 300 ppm, impaired IJ exsheathment and development. The highest concentration of I. viscosa extract (2400 ppm) had the strongest effect, killing 95% of exposed nematodes. Surviving nematodes did not recover, remaining at the IJ stage. Over the whole cycle, I. viscosa extract inhibited recovery to 25% or less, and did not allow full development to adulthood, whereas 65% of IJs in the control treatment recovered and resumed development, 12% reaching complete maturation within 72 h of incubation. When herbivorous S. littoralis larvae were fed with different plant extracts in vivo, I. viscosa had the strongest effect at concentrations above 300 ppm, with 90% of insect-invading IJs not developing to parasitic stages, whereas in the control treatment, 85% of IJs resumed development. Exposure to C. siliqua extract also inhibited exsheathment and development of 75% of the IJs. Half of those that resumed development reached full maturation. P. lentiscus and Q. calliprinos extracts also inhibited development of 50% IJs. Our results suggest that H. bacteriophora can be used to study herbal medication against parasites in animals.
Internazionale — AUPxport

Una maggiore capacità di esportazione in nuovi mercati e nuove geografie per commercializzare le soluzioni sviluppate dall'azienda nell'ambito dei progetti R &D, ha ampliato la rete dei clienti con nuovi approcci al mercato.
Ecovillages as laboratories of sustainability and social change

In an historical moment where citizens of the world are called to take action to face ´multiple crises´- the emergency of climatic change, high and rising socio-economic inequalities, and the upsurge of intolerance and racism within and between countries -  the study of transformative grassroots initiatives becomes crucially important and timely. 

‘Ecovillages as Laboratories of Sustainability and Social Change´ (EcoLabSS) is conceived as an international, inter-sectoral and interdisciplinary project aiming at producing a theoretically grounded and methodologically innovative study of one of these grassroots initiatives: the ecovillage movement. 

EcoLabSS provides a multi-level and mixed-method study of the ecovillage movement that combines the comparative study of two local ecovillages, respectively in Denmark and Italy, with a systematic analysis of the actions and networks of the transnational organization Global Ecovillage Network (GEN). The review and the fieldwork is then used to develop a comprehensive theoretical and analytical framework centred on the path-breaking definition of ´community-based prefigurative social movements´. 

The empirical analysis is structured along three mutually informing levels of analysis: micro-individual level, meso-community level, and macro-societal level. The first level is focused on the study of individual life trajectories and biographies of ecovillage inhabitants. The meso-community level is analyzing the everyday practices and processes involving organization, decision-making and creation of future-oriented norms and codes of conduct inside the two case studies. Finally, the macro-societal level is centred on the study of how the ecovillage movement - represented by the transnational organization GEN - translates and diffuses its practices, narratives and visions of a just and sustainable society to policy-makers, institutions, other civil society actors and the wider public.
A safe diva vaccine for african swine fever control and eradication

African Swine Fever (ASF) is one of the most important viral diseases affecting swine, with a serious socio-economic impact. It is present in more than 13 countries in Europe (10 in the EU), 28 sub-Saharan African countries, and 2 Asian countries, China and Mongolia. No vaccine is available and recent incursions in Europe and Asia are jeopardizing the pig industry worldwide. Control of ASF is based on early diagnosis and the implementation of strict sanitary measures. However, measures taken by affected countries have not been sufficient to stop spread. 
The objective of VACDIVA is to solve the ASF problem in Europe and affected countries through innovation efforts. VACDIVA will provide (1) Three safe and effective pilot vaccines for wild boar and domestic pigs ready for registration; (2) validated companion DIVA tests and 3) cost-benefit and effective surveillance and control-vaccination strategies, with field trials in Lithuania and Kenia. Two world leader companies in vaccine production and ASF diagnostic kits will provide production of the new vaccines and DIVA tests. Epidemiological modelling of worldwide scenarios will be offered in a portfolio of services to help animal health authorities control and eradicate the disease. This project will provide policy makers valuable decision support tools to better prevent and control ASF. 
VACDIVA counts with the expertise of two world ASF Reference Laboratories (OIE and FAO), the EU reference laboratory (EURL), six EU national Reference Laboratories (of 6 out of the 10 countries currently affected by ASF) and four prestigious ASF research institutions. Participation of Russian, Chinese and African laboratories will provide useful support, increasing acceptance of the vaccines. Active involvement of pig producers, agricultural associations and International agencies like FAO will enlarge the impact of communication, dissemination and training activities.
Intensification of export activity of the company Spółdzielnia Invalidów “METAL” on foreign markets in order to promote the brand of the Polish Economy.

SA 42799(2015/X) The object of the project is the participation of the Invalidity Cooperative “METAL” in the Programme for the promotion of the machinery and equipment industry. As a result of its participation in the Programme, the company will significantly increase its export activity on selected foreign markets: the US (non-EU forward market), German and Scandinavian (in particular Finland and Sweden) through the promotion of the SI “METAL” product brand. According to the Programme, in the period 01.06.2020-31.12.2022: 1) Participation in international fairs as an exhibitor: — Hannover MESSE, Hannover 2020, – INNOTRANS, Berlin 2020, – HANNOVER MESSE, Hannover 2021, – EASTEC, USA 2021. — Subcontracting, Poznań 2021, – SUBCONTRACTING Alihankinta, Finland 2021, – ELMIA SUBCONTRACTING, Sweden 2021, – Bautec, Berlin 2022, – BAUMA, Munich 2022. 2) Additional promotional activities. The object of the promotion will be the range of products – finished metal products. The scope of the company’s activities is in line with the Programme for the Promotion of Machines and Devices, and the implementation of the project will have a positive impact on the promotion of the product brand of the Polish economy. Through planned projects, the Applicant will have the opportunity to expand his export activity and gain new foreign markets by attracting a wide group of customers interested in the company’s products. Participation in the Programme will enable effective promotion of the SI “METAL” brand and will contribute to building a positive image of the Polish industrial industry on the international stage. The company has a stable financial situation, allowing for smooth implementation of the tasks planned in the project. Pending reimbursement and/or advance payment from EU funds, the project will be financed from the company’s own resources.
Implementation of the rental service as an opportunity for the development of the company

The project will consist of the purchase of new services indicated in the Budget, which will directly contribute to the introduction of new services. Therefore, the project will lead to diversification of the Company’s offer, the realisation of the objectives of the project will be possible thanks to the planned investments. The project will be implemented in the Voivodeship. The Lower Silesian. The tasks provided for in the project will follow each other in a logical dependency, in order to ensure their full consistency, the implementation will be based on an analysis of possible hazards and the possibility to mitigate them, while taking into account the project’s intended results. The project will allow to broaden the scope of the Applicant’s activities with new, previously unoffered services: renting campers. The planned investments will adapt the company to the provision of services such as: rental of campers equipped with access to RES. In addition, pro-environmental effects will be achieved thanks to the investment in camper, which will contribute to reducing environmental pollution. The investment will be financed from a loan, own funds and the Applicant also plans to use the advance.
Current challenges and advances in butanol production

Abstract The fluctuating and overall average high market prices of fossil fuels have impacted the geopolitical scenario in the past few decades. In the majority of the United States this has resulted in policy shifts toward developing technologies for the use of renewable resources as feedstock for the production of biofuel and other valuable products. The biofuel butanol is mostly produced commercially by the acetone–butanol–ethanol (ABE) fermentation pathway using the Clostridium species. This strain consumes diverse sources of substrate via its anaerobic metabolic pathway. The biological production of butanol was one of the largest industrial fermentation processes during the early 20th century, but it lost its competitiveness by the 1960s due to the cost of substrates and with the advent of more efficient petrochemical processes. Other challenges in ABE fermentation have also restricted its growth in commercial production through fermentation. Advances in the fields of biotechnology, systems biology, metabolic engineering, and innovative process development have renewed the interest in the ABE fermentative process from its conventional roots. This chapter reviews the conventional butanol production process and addresses the problems and challenges that must be overcome in butanol production. Moreover, this chapter expands on current research trends in the development of production processes in areas like pretreatment, anaerobic and aerobic fermentation pathways, genetic modification of strains to enhance solvent production, and downstream processes for solvent extraction. The chapter also provides an analysis of the overall butanol fermentation process with a focus on improving the efficiency of the fermentation stage by altering the upstream (pretreatment of the raw material) and downstream (product recovery and purification) processes as a major possibility for development.
Method of topological relations query processing based on MBR&IR

In order to improve the query efficiency of spatial database system,the method of topological relations query processing based on MBRIR is proposed by introducing IR into the R* tree index structure based on the traditional topological relations query method.The basic idea is that the data objects that satisfy the query conditions are selected while the data objects that do not satisty the query conditions are excluded by increasing the constraint condition of IR during the filte step,which will improve the performance of fiter step and reduce the system cost.Therefore,the query efficiency is improved.The experimental result shows that the method of query processing based on MBRIR outperforms the traditional topological relations query method.
Higher Order Classical Density Functional Theory for Branched Chains and Rings

We develop a general density functional theory for polyatomic molecules by taking the complete association limit of Wertheim's thermodynamic perturbation theory in a general way. By enforcing the complete association limit at an early point in the derivation and introducing the concept of molecular graphs, a general form for the free energy functional and segment densities are developed for both rigid and semiflexible molecules. The theory is applicable to branched chains, rings, or any other molecular structure. As an example the theory is applied as a second order perturbation theory to the case of molecules with a rigid three segment head and a fully flexible tail in a slit pore where bond angle of the rigid portion is an independent variable.