SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Mainstreaming biodiversity management efforts for environmental sustainability

The Med Biodiversity Protection Community/MBPC ("PANACeA2") is a horizontal project focusing on objective “maintaining biodiversity and natural ecosystems through strengthening the management and networking of protected areas”. It builds on achievements to increase the impact of modular projects’ towards common identified targets and links through:1) Synthesizing and tranferring outcomes on ecosystem protection efforts;2) Engaging a stakeholders’ community & transferring knowledge beyond the community and the project´s lifetime,3) Enhancing the communication & dissemination strategy,4) Developing the long term capitalization tool ensuring evidence based policy enforcement.The activities ensure an active community of Mediterranean actors meant to overcome sectoral borders by integrating knowledge, allowing a better informed multilevel decision-making and management of biodiversity.The MBPC facilitates multisectoral dialogue with the scientific community to ensure an effective policy-management-science interface in the Mediterranean related to biodiversity protection and sustainable development. It pursues the long term strategic goal of the Interreg MED programme by reaching beyond EU Member States into the whole Mediterranean basin. It aims to feed EU, UNEP/MAP Barcelona Convention and CBD policies linked to the protection of natural resources for sustainable development in Mediterranean protected areas and key ecological function units and ecosystems.
Effects of Diazinon and Fipronil on Different Developmental Stages of Trichogramma brassicae Bezdenko (Hym.; Trichogrammatidae)

The integration of biological and chemical control approaches is very important for a successful Integrated Pest Management (IPM) program. Demographic approaches give a better understanding of the side effects of pesticides on beneficial organisms. In this study, laboratory bioassays were set up to evaluate the lethal and sublethal effects of diazinon and fipronil on different stages of Trichogramma brassicae Bezdenko (Hymenoptera: Trichogrammatidae). The effects of Field Recommended Concentration (FRC) of diazinon and fipronil were studied on larvae, prepupa and pupae of the parasitoid. Diazinon and fipronil reduced adult emergence by 99.74 and 50.46%, respectively. The LC 50 values for diazinon and fipronil on adult stage were 0.11 and 0.46 µg ai ml -1 , respectively. The sublethal effects of the chemicals were studied on life-table parameters of the parasitoid emerging from parasitized eggs exposed to the FRC of the insecticides at larval stage and also adults exposed to LC 30 of the insecticides. Longevity and progeny production were affected by the insecticides in comparison to the control. Three main lifetable parameters including intrinsic rate of increase ( rm), Doubling Time (DT) and net Reproduction rate ( R0) were negatively affected by the sublethal treatments. The intrinsic rate of increase for control, diazinon and fipronil exposed populations at larval stage were 0.28, 0.23 and 0.12, respectively and were 0.26, 0.04 and 0.08 for populations exposed to LC 30 at adult stage, respectively. The sex ratio of offspring at all insecticide treatments has led to the production of female offspring by the chemicals. These findings showed that diazinon and fipronil were harmful for T. brassicae , thus semifield and field studies are suggested for getting more applicable results for possibly using them in IPM programs.
Molecular characterization of the role of intra-tumor heterogeneity in cancer progression and metastasis

Cancer  is caused by somatically acquired changes in the DNA. Some of these changes fall in “cancer genes”, conferring clonal selective advantage to the cells that carry the mutant alleles. Identifying these genes/pathways is of vital importance for a correct understanding of cancer biology as well as for the diagnosis and treatment of human malignancies. In this respect, the use of genetically modified mice has been extremely useful in the past for characterizing the molecular pathways involved in cancer progression. The remarkable progress made during the last two decades on the genetic modification of mouse genomes offers unique opportunities to investigate different aspects of tumor molecular behavior, impossible to study on human samples. 
  Recently, the advent of next-generation sequencing technologies has provided new strategies for the systematic genome-wide identification of somatic changes in cancer cell genomes. Using these technologies, we and others have characterized the high intra-tumor heterogeneity observed in some human tumors. Although the exact significance of this heterogeneity is uncertain, it seems to be responsible for key aspects in the management of cancer patients such as metastasis predisposition and tissue specificity or treatment resistance.  
 Taking advantage of next-generation sequencing, we propose to finely characterize the intra-tumor heterogeneity evolution during the progression of tumors induced in a mouse model of pancreatic cancer, as well as, for the first time, to purify the different cell populations these primary tumors are composed of. A complete genomic and transcriptomic characterization of these populations followed by posterior functional assays will help us to identify the genes/pathways involved in tumor progression as well as metastatic potential and its tissue specificity. This new knowledge could finally contribute to a better understanding of cancer and to the design of more efficient anti-tumor therapies
STABLUM REBORA ASSOCIATE STUDIE

DIE STABLUM REBORA ASSOCIATE STUDY BESTEHT AUS ZWEI BUCHHALTERN UND 5 MITARBEITERN UND EINEM AUSZUBILDENDEN. DAS UNTERNEHMEN BESCHÄFTIGT SICH MIT STEUER-, STEUER-, UNTERNEHMENS- UND ARBEITSBERATUNG SOWIE MIT EINEM INHABER, DR. LUCA REBORA, DER SICH MIT INSOLVENZ- UND IMMOBILIENAUSFÜHRUNGEN BEIM GERICHTSHOF VON SAVONA BEFASST UND IN DER LISTE DER RECHNUNGSPRÜFER EINGETRAGEN IST UND DERZEIT ZWEI PRÜFUNGSPOSITIONEN HAT. DIE AKTIVITÄT ERFORDERT EINE DIGITALISIERUNG DER STUDIE, DAMIT ALLE KOMPONENTEN AUFGRUND DES EPIDEMIOLOGISCHEN RISIKOS VON COVID-19 ZU JEDER TAGESZEIT UND INSBESONDERE VON ZU HAUSE AUS VERBUNDEN WERDEN KÖNNEN. DIE DAMIT VERBUNDENE STUDIE VERZEICHNETE 2019 EINEN UMSATZ VON ÜBER 400,000 EUR UND BERIET MEHR ALS 500 UNTERNEHMEN (ZWISCHEN UNTERNEHMEN, EINZELNEN UNTERNEHMEN UND FACHLEUTEN).
Silent mutations in cancer

Our genome contains 20 000 genes, which are transcribed into mRNAs. These mRNAs are then in turn translated into proteins that exert the cellular functions. In the past decade, researchers have analysed the genetic sequence of all protein coding genes in thousands of tumor samples, with the aim to identify gene defects (‘mutations’) that cause cancer. In most of these studies, only gene mutations that cause amino acid changes in the proteins for which they encode were analysed, and it was assumed that mutations that do not cause amino acid changes (=synonymous or silent mutations) are innocent and meaningless events in cancer pathogenesis. 
Despite the fact that synonymous mutations have thus largely been ignored by cancer researchers, there are a couple of synonymous mutations that have been shown to promote cancer. This happens via highly novel and poorly understood mechanisms of gene expression dysregulation that occur at the level of gene transcription to mRNA or at the level of translation of the mRNA into protein. Since the role of synonymous mutations in cancer has not been systematically explored so far, and since there is thus evidence that these mutations are not as ‘silent’ and innocent as many people think, we hypothesized that the pathogenic role of synonymous mutations in cancer is largely underestimated. First, we will delineate the landscape of synonymous driver mutations in cancer. For this purpose, we will develop bioinformatics and statistics approaches to identify relevant synonymous mutations in previously generated sequence data from 11 400 tumor samples. Furthermore, we will apply in silico methods to rank identified mutations and filter out the mutations that are predicted to most efficiently promoting cancer. For 50 of the mutations that are predicted to be pathogenic, we will perform wet lab experimental testing of their capacity to alter gene expression level and to promote cancer cell behavior. Special attention will go to mutations that affect poorly characterized mechanisms to regulate the efficiency of protein translation of the mutated gene, because our lab has a strong expertise in this field. Results from this project may also be relevant for more classical non-synonymous mutations, because the novel modes of gene expression regulation we will discover might also be relevant for such mutations, and the project may thus have broad very implications in the cancer field. 
Synonymous mutations are currently difficult to find for researchers. We will make these mutations visible via a public website and we will make the methodology we develop in this project available to the research community. This project will thus give silent synonymous mutations a voice through their first comprehensive characterization in cancer.
Dispositif de flambage automatisé

L’objectif du projet est de développer une solution conseptative et un modèle 3D simplifié et des dessins généraux pour le dispositif de flambage automatisé de l’industrie du bois.
Microchannels for controlling cellular mechanotransduction

Cells respond to external mechanical stimuli through an activation of a cellular mechanism called mechanotransduction. The cellular responses in this mechanism are expressed by a modification in cellular proliferation, migration and differentiation, as well as in a strengthening of their adhesion. Likewise, diseases such as cancer and cardiac dysfunctions are also related to cellular mechanotransduction. Here we propose to take a novel 3D material porous material towards commercial applications. The material serves as a platform for controlling mechanotransduction (e.g. in implant materials) and enables a control of mechanotransduction by mimicking natural 3D cellular environments. Our material contains a novel form of microporous structures represented by micron-sized channels embedded in a polymer matrix of a well-defined stiffness that has been developed within the ERC project CELLINSPIRED. The material guarantees pore interconnectivity independently of pore density and size, a unique feature offered by our fabrication procedure, for which we have applied for a patent (EP 15166793.8, PCT/EP2016/060160). Furthermore, it also provides a large, three-dimensionally controlled cell-surface contact area, such that the mechanical properties of the environment will have large impact on the cells. Our goal in this project is to validate our novel material for cellular applications where mechanotransduction is targeted. The expected outcome of our project is to receive a demonstrator material that (1) has well-defined mechanical properties, porosities and pore dimensions, (2) is biocompatible and can be sterilized, (3) can be fabricated in different levels of complexity, (4) can activate mechanotransduction in cells, and (5) can be fabricated using high-throughput processes. As for commercialization, we aim to license the patent to biomaterials companies involved in applications that range from 3D cell cultures to implant materials.
Preserving wooden heritage. methods for monitoring wooden structures: 3d laser scanner survey and application of bim systems on point cloud models

Wooden Heritage has been recognized today as an object of growing interest in scientific research even on international scale, not only from the architectural point of view but also from theoretical approaches. Over the times many technological systems concerning timber have evolved, refined and defined in the use of mixed solutions. Wooden Architecture represents one of the oldest building systems adopted by the majority of people who developed construction techniques respecting the local traditions. Today this vast and unique wooden heritage needs urgently survey and cataloguing. Fires and abandonment are the main factors jeopardizing the preservation of this architecture; every year too many wooden buildings still disappear because of this negligence. This important challenge has the purpose to obtain new technical methods, procedures and protocols that don’t exist yet, fundamental for technicians and operators. The research project wants to address a new scientific approach on wooden buildings. This is aimed for practical interventions for with respect to the scientific and epistemic foundations, by improving 3D laser scanner survey and photo-modelling activities through post production phases with parameterization of the point cloud to create 3D digital models queried and enriched by informative content and increase BIM (Building Information Modeling) knowledge. The main and most important contribution of this project is the accomplishment of scientific, technical and operational systems and tools for the documentation of wooden structures. During the process of analysis different experts belonging from the best host companies chosen, will guide, check and develop jointly with the applicant all the methods, procedures and theoretical background for achieving the best results in a successful project. In this way the triangle Research-Theory-Practice will offer new insights to timber architecture, to the preservation and maintenance of the wooden heritage.
Il Jardines El Capricho a Madrid. Dall’analisi delle fonti d’archivio al rilievo fotogrammetrico

che ha consentito di conoscere l'evoluzione storica del Parco grazie all'analisi dei documenti d'archivio e una seconda fase finalizzata, invece, alla conoscenza dello stato attuale dei luoghi ed alla comprensione delle caratteristiche architettoniche e naturalistiche.Attraverso il rilievo strumentale con fotogrammetria terrestre è stato possibile comprendere la morfologia e la geometria di alcune delle architetture e degli spazi a verde e la relativa elaborazione di disegni bidimensionali e modelli 3D.I risultati della ricerca sono incentrati sul rilievo fotogrammetrico di tre elementi architettonici: il templete de Bacos, el Abejero ed el Ermitaño del Capricho.In seguito, le metodologie applicate per la conoscenza del luogo saranno la base per l'utilizzo prossimo di strumenti tecnologici avanzati, per la fruizione virtuale del sito oggetto di studio.
Efficacy of synbiotic and probiotic treatments on acute watery diarrhea in children

Background In developing countries, acute watery diarrhea isa common cause of morbidity and mortality in children. Givingsynbiotics or probiotics may decrease the severity of diarrhea.Objective To compare the efficacy of synbiotics and probioticsin decreasing the frequency of diarrhea, shortening the duration,and increasing patient body weight.Methods This was a double􀀷blind, randomized clinical trial tocompare the effects of synbiotic vs probiotic treatment in childrenaged 6􀀷59 months v.ith acute watery diarrhea. This study wasperformed from October to December 2010 in two hospitals inCentral Java. Subjects received either synbiotics or probioticstv.ice daily for five days. The measured outcomes were durationof diarrhea, daily frequency of diarrhea, and increase in bodyweight.Results There was no significant difference in the mean durationof the diarrhea in the synbiotic and probiotic groups, 3.92 days(SD 0.79) vs 3.80 days (SD 0.82) ,(P􀀸0.35), respectively. Nor didwe observe a significant difference in the mean increase in bodyweight in the synbiotic and probiotic groups, 150 g (SD 49.7) vs160 g (SD 48.9), (P􀀸 0.67), respectively.Conclusion We observed no significant differences in efficacy ofsynbiotic and probiotic treatment for management of acute waterydiarrhea. [Paediatr Indones. 2012;52:209,12].
Microrna isoforms for molecular interception of cervical cancer using self-samples

With 13,000 deaths each year in the EU, cervical cancer (CC) is one of the deadliest cancers worldwide. This is unnecessary, since CC is well detectable and treatable at early stages. For this reason, most EU countries have screening programs in place. These screening programs have had (varying) success in reducing CC incidence, however, this reduction has reached a plateau and new strategies are needed to improve screening success.
An important reason for the stagnating decline in CC incidence is the relative high rate of non-compliance to screening because the gynaecological procedure to collect a sample is seen as highly uncomfortable and very invasive. Offering self-sampling options increases the participation rate in non-responder women by 30%. However, self-sampling is not compatible with the current cytology-based screening method (e.g. Pap test). There is thus a great need for the development of new, molecular screening assays for CC that can be used on self-samples.
In the ERC-AdG MASS-CARE, we investigate the value of two classes of molecular markers, DNA methylation and miRNA for the detection of cervical disease in self-samples. In our analyses, we frequently observed variations at the 3’ end of the miRNA markers. Such variations (isomiRs) have great impact on their detectability by standard assays and thus specific assay development for these isomiRs constitutes a great improvement compared to using the canonical miRNA sequence. 
In MIMICS, we aim to select the isomiRs with the strongest association with CC which therefore have added value as disease biomarker compared to the canonical miRNAs. The identified isomiRs, which improve CC detection compared to the canonical miRNAs will be added to the panel of DNA methylation and canonical miRNAs as identified in the ERC-AdG. This assay will constitute the first full molecular, non-morphology-based, objective screening assay for cervical cancer fully compatible with self-sampling.
METHOD, SYSTEM AND APPARATUS FOR ENTRAINING GLOBAL REGULATORY BIO-NETWORKS TO EVOKE OPTIMIZED SELF-ORGANIZING AUTONOMOUS ADAPTIVE CAPACITIES

The invention interacts with a subject to query, challenge and identify multiple aspects and multidimensional influences that provide access to, allow modulation of, and entrainment of, state-specific global bio-regulatory self-organizing controllers and evocable triggers. Modulation of state-specific regulatory triggers may evoke optimized newly emergent self-organizing principles within the subject and ultimately support up-regulation of "states of presence" that include newly emergent controllers of additional optimal regulation of bio-chemical expressions. The "state" measures of a person may include the status of a combination of any number of identified biological qualities. The invention includes systems and methods that support access to a subject's state controller functions, for various aliments, to empower shifting ones' biology from a symptomatic to an asymptomatic state and to optimal adaptive learning and readiness. The system of the invention investigates and accesses the capacities that control such state shifts so that they can be broadly challenged, expanded, and entrained for optimized global regulatory function in reversing a myriad of pathological symptoms, learning limitation, and adaptive dysregulations.
Effect of Zn substitution on the electromagnetic and microwave absorbing properties of BaCo2 hexaferrite

A series of Zn doped BaZnxCo2−xFe16O27 (x = 0, 0.3, 0.5, 0.7, 0.9, 1.2) W-type hexaferrites were successfully synthesized via chemical co-precipitation method. The XRD result showed that the structure of W-type hexaferrite has not been affected by the substitution of Zn. The morphology of the particles measured from SEM was the flat hexagonal sheet with large size about 15 μm and high aspect ratio of ~20. And the complex permittivity and permeability of BaZnxCo2−xFe16O27 which were determined by microwave vector network analyzer in the frequency of 1–18 GHZ was calculated based on the measured data. For the sample with x = 0.7, the minimum reflection loss of −52.8 dB was obtained at 12.8 GHz and the effective absorbing bandwidth reached 4.5 GHz for the sample with the thickness of 2.1 mm. At the thickness of 2.5 and 3.0 mm, the minimum reflection loss were −14.7 dB at 10.35 GHz and −13.2 dB at 8.1 GHz and the effective absorbing bandwidth were 4.93 and 2.21 GHz, respectively.
METHODS OF PRODUCING WEIGHT LOSS AND TREATMENT OF OBESITY

Methods are disclosed for the acute and chronic treatment of obesity using drugs whose mechanism includes the interaction and antagonism of the kainate/AMPA receptor. Methods are disclosed for employing the drug topiramate (topomax) as monotherapy or in combination therapy eith lamotrigene, valproic acid, valproic acid and carbamezepine combination, or felbamate (felbatol).
Juvenile specimen of Megaraptor (Dinosauria, Theropoda) sheds light about tyrannosauroid radiation

Abstract Megaraptorids are a group of predatory dinosaurs that inhabited Gondwana from Cenomanian to Santonian times (Late Cretaceous). Phylogenetic relationships of megaraptorids have been matter of recent debate, being alternatively interpreted as basal coelurosaurs, carcharodontosaurian allosauroids, megalosauroids, and basal tyrannosauroids. One of the main reasons for such different interpretations is the incomplete nature of most available megaraptorid skeletons and, in particular, the scarce information about their cranial anatomy. Here we describe a partially preserved skeleton of a juvenile specimen of Megaraptor namunhuaiquii that provides substantial new information about the cranial morphology of this Patagonian taxon. The specimen comes from the Upper Cretaceous (Turonian–Coniacian) of the Portezuelo Formation, northwestern Patagonia, Argentina. The anatomy of the new specimen bolsters the recently proposed hypothesis that megaraptorids are nested within Coelurosauria, and possibly within Tyrannosauroidea. The most relevant features that megaraptorans share with tyrannosauroids include several foramina on the premaxillary body, extremely long and straight prenarial process of the premaxilla, incisiviform premaxillary teeth with a D-shaped cross-section, and cranially expanded supratemporal fossae separated from each other by a sharp sagittal median crest on frontals, which was presumably extended caudally above the parietals (not preserved). Information gathered from the present specimen allows to make for the first time a reconstruction of the skull of Megaraptor and hypothesize about evolutionary trends within Tyrannosauroidea.
[Foetal therapy for spina bifida].

Spina bifida is the most common congenital birth defect involving the central nervous system. It results in central and peripheral abnormalities. Patients with severe spina bifida may have a lifelong disability with dependence on medical and social supportive care. A randomized controlled trial demonstrated that, for a selected number of patients, prenatal closure of the defect resulted in a better neurological outcome than postnatal surgical repair. Prenatal surgery of spina bifida is associated with an increased risk of preterm birth and obstetric complications and is not yet considered the standard of care in the Netherlands. In case of a prenatal diagnosis of spina bifida, the pregnant woman is entitled to full information about the possibility of prenatal treatment and to a possible referral for this.