SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Spatio-Temporal stochastic models for phenotype and gene regulation by the human papillomavirus

Human papillomaviruses (HPVs) cause a range of serious diseases, with particular regard to cervical cancer, most anal cancers and half of head and neck cancers, and the need for new and effective antiviral therapies is of paramount importance. Important advancements regarding the HPV infection, throughout the infected epithelium, have been recently made. However, a full mechanistic understanding of how stochastic and dynamical properties of the HPV gene network interact with the cellular circuitry that controls proliferation/differentiation and cell-to-cell communication affects responses at the single cell and tissue level during infection is lacking. A better understanding of these aspects is critical to understand viral persistence, cancer progression, and to develop novel strategies for antiviral therapies. Mathematical models, developed under rigorous mathematical and biological assumptions, can be of great help in generating optimal solutions to these problems. STEPV project aims at improving the current available frameworks for stochastic tissue-level mathematical modeling, by tackling their limitations and specialize them in the context of HPVs, as well as to improve clinical/biological discoveries about HPVs infection. The specific goals are: (1) development of novel spatio-temporal modeling frameworks in order to describe HPVs gene expression and its connection with the phenotype control; (2) use of the developed models to understand the phenotype regulation by oncoproteins, understand viral persistence and propose novel antiviral strategies. By achieving these goals, STEPV will provide, for the first time, innovative modeling frameworks in the field of the computational systems biology applied to the context of HPVs infection, allowing quantitative and noninvasive tools to deeply investigate still elusive mechanisms, regarding HPVs infection, as well as investigate inaccessible or poorly understood clinical/biological scenarios.
Hydrogen evolution cell having a cathode pocket

A hydrogen evolution cell which on passage of an electric current liberates an amount of hydrogen proportional to an amount of current flowing through, includes an electrochemically oxidizable anode, a hydrogen cathode, an electrolyte and a casing surrounding the same, wherein the hydrogen cathode is associated structure of at least one pocket defining a hollow space or defines a hollow space in the presence of hydrogen overpressure or wherein the cathode forms such a pocket.
IOT E SISTEMI DI MONITORAGGIO IN TEMPO REALE

IMPLEMENTAZIONE DI UN SISTEMA DI MONITORAGGIO DEGLI IMPIANTI PER UNA MANUTENZIONE PREDITTIVA, LA SOSTENIBILITÃ  AMBIENTALE E L'EFFICIENZA DEI PROCESSI. VERRANNO INTEGRATE IN AZIENDA SOLUZIONI DI NETWORKING DEL INTERNET OF THINGS ATTE AD AUMENTARE LA PRODUTTIVITÃ  DEGLI IMPIANTI E GESTIRE IN MODO EFFICIENTE LA MANUTENZIONE
Photothermal activation in the near infrared range for 4-dimensional printing using relevant organic dyes

teaching and research institutions in France or abroad, or from public or private research centers.L'archive ouverte pluridisciplinaire HAL, est destinée au dépôt et à la diffusion de documents scientifiques de niveau recherche, publiés ou non, émanant des établissements d'enseignement et de recherche français ou étrangers, des laboratoires publics ou privés.
Safe personal transportation that makes you healthier.

The “last mile” between hubs and homes, as well as short distance transport needs for persons with walking limitations, are urban mobility challenges that we address at Torqway Company Ltd with a new way to move. Our manual-powered four-wheel platform vehicle introduces “Nordic Driving”, driven by arm movement on levers with an innovative gear system (under patent in 9 countries) which converts every movement into forward motion up to twice the speed of normal walking. 
Based on this core technology, Torqway Hybrid offers additional electric motor assistance like an e-bike for senior users and persons with reduced lower body mobility. Medical studies on Torqway confirm that the arm movements while standing induce isometric muscle contractions shown to improve upper and lower body strength, coordination and weight control.
This innovative outdoor vehicle consistent with the Transport and Smart Cities framework and the Electric Mobility Europe initiative can be used in several ways: as an active mobility and transportation device, as an outdoor gym joining several exercises in one and as a tool for light physical rehabilitation. Aside from individual purchasers, sales target sport and physiotherapy centres, tourism and leisure mobility. 
As confirmed by our Phase 1 Feasibility Study, Torqway Hybrid end users are 55+ y.o. early adopters of both sexes with purchasing power in EU member states with established bicycle use and infrastructure, starting with Germany, Netherlands, Nordic coutries, Poland and USA. Markets are segmented into growth sectors that reflect increasing expenditure by an aging, health-conscious population: Fitness equipment (global market worth 10.38 bn USD), Personal mobility (worth 6.65 bn USD), Home physical rehabilitation (worth  2.86 bn USD) and Physiotherapy (worth 14.3 bn USD). As a reference, the global E-bikes market is worth 15.90 bn USD and growing at double-digit rates.
Excitation migration in fluctuating light-harvesting antenna systems

Complex multi-exponential fluorescence decay kinetics observed in various photosynthetic systems like photosystem II (PSII) have often been explained by the reversible quenching mechanism of the charge separation taking place in the reaction center (RC) of PSII. However, this description does not account for the intrinsic dynamic disorder of the light-harvesting proteins as well as their fluctuating dislocations within the antenna, which also facilitate the repair of RCs, state transitions, and the process of non-photochemical quenching. Since dynamic fluctuations result in varying connectivity between pigment-protein complexes, they can also lead to non-exponential excitation decay kinetics. Based on this presumption, we have recently proposed a simple conceptual model describing excitation diffusion in a continuous medium and accounting for possible variations of the excitation transfer pathways. In the current work, this model is further developed and then applied to describe fluorescence kinetics originating from very diverse antenna systems, ranging from PSII of various sizes to LHCII aggregates and even the entire thylakoid membrane. In all cases, complex multi-exponential fluorescence kinetics are perfectly reproduced on the entire relevant time scale without assuming any radical pair equilibration at the side of the excitation quencher, but using just a few parameters reflecting the mean excitation energy transfer rate as well as the overall average organization of the photosynthetic antenna.
Is there a gender gap in child nutritional outcomes in rural China?

Abstract In this paper, we use data from the China Health and Nutrition Survey (CHNS) to examine if there are any gender differences in child anthropometric outcomes among rural Chinese children, explicitly taking into account the role of China's family planning policies. Our analysis shows that although there have been improvements in the child anthropometric measures height-for-age and weight-for-age over the last two decades, children, particularly girls from non-one child households have adverse nutritional outcomes. These gender differences persist in two-child households, where boys have better height-for-age outcomes when their sibling is a male rather than a female. Our decomposition model finds that there is a large unexplained component, which may be attributed to gender discrimination against the girl child.
Relating gas ascent to eruption triggering for the April 27, 2016, White Island (Whakaari), New Zealand eruption sequence

The April 27, 2016 eruption sequence at White Island was comprised of 6 discrete eruptive events that occurred over a 35-min period. Seismicity included three episodes of VLP activity: the first occurring ~ 2 h and a second occurring 10 min prior to the first eruption. A third larger VLP event occurred just prior to the fourth eruption. A VLP source depth of 800–1000 m below the vent is obtained from an analysis of the waveform semblance, and a volumetric source is obtained from waveform inversion of the largest VLP event. Lag times between VLP occurrence and eruption onsets provide an opportunity to examine gas migration and stress transfer models as potential triggers to the eruptive activity. Plausible lag times for a deep gas pulse to the surface are obtained by application of a TOUGH2 computational model which suggests propagation times of 0.25–1.9 m/s and are informed by previously measured White Island rock porosities and permeabilities. Results suggest that pre-eruption VLP may be plausibly linked to advection of gas from the VLP source at a magmatic carapace located ~ 800–1000 m depth. Alternatively, the large VLP that occurred just prior to the fourth eruption may be linked to a quasi-dynamic or quasi-static stress perturbation.
Chromosome-Based mechanisms of transcriptional inactivation during mitosis

Coordination between major cellular functions, such as transcription and proliferation, is critical to ensure cell survival. It has long been recognised that while in mitosis, cells switch-off most of their transcriptional activity. While Mitotic Transcriptional Inactivation (MTI) is entrenched as a dogma in cell biology, its functional consequences have been difficult to pin down, as manipulating MTI in the context of a developing organism has been difficult until now. My lab has pioneered the use of acute perturbation approaches to dissect cellular process with unprecedented temporal resolution, which hold the prospect of surpassing current limitations on the identification and manipulation of multiple MTI layers. Using these novel approaches, ChromoSilence aims to test the hypothesis that MTI is a vital process for proper genome partitioning and transcriptional control. We will focus our analysis on chromosome-based events, that we propose as key contributors for MTI regulation, and test how classic chromosome assembly factors impact on mitotic transcriptional shutdown. In parallel, and supported by strong preliminary observations for a putative candidate, we will identify and reveal the function of novel players involved in chromosome-based mechanisms to drive MTI. New knowledge on the MTI mechanisms will be used to develop tools to uncover the role of this transcriptional shutdown in the fidelity of nuclear division and thereby identify novel routes to maintenance of genome stability. We will additionally uncover how the transcriptional silencing during mitosis may impact on maintenance of transcriptional programs in various developmental contexts. Collectively, ChromoSilence will reveal that MTI is not a by-product of passage through mitosis but instead an essential process for accurate chromosome segregation, maintenance of cell identity and organism development.
Custo-efetividade de Alentuzumabe vs. Natalizumabe no tratamento de terceira linha da esclerose múltipla remitente recorrente para a saúde suplementar no Brasil

Objetivo: A esclerose múltipla é uma doença crônica, inflamatória e degenerativa do sistema nervoso central que afeta aproximadamente 2,5 milhões de pessoas no mundo. Cerca de 80% dos casos são classificados no fenótipo ‘remitente recorrente’ (EMRR). Avaliou-se, sob a perspectiva de pagador na saúde suplementar no Brasil, a relação de custo-efetividade do tratamento com alentuzumabe em pacientes de EMRR em 3a linha de tratamento versus natalizumabe, único tratamento disponibilizado na saúde suplementar atualmente. Método: Com auxílio de modelo de Markov, simulou-se, no horizonte temporal de 30 anos, uma coorte de mil pacientes, com parâmetros demográficos baseados em dados do sistema público de saúde do Brasil. Em cada ciclo anual, os pacientes poderiam transitar entre diferentes estados de saúde, mensurados através do escore na Escala Expandida de Estado de Incapacidade (EDSS), além de experienciar surtos e progressão para o tipo secundariamente progressivo. A distribuição da população inicial da coorte por nível de EDSS baseou-se no estudo clínico CARE MS II. Os parâmetros de eficácia relacionados à progressão de incapacidade e taxa de surtos foram selecionados de metanálise de rede, assim como taxas de descontinuação e retratamento, parâmetros de utilidade, segurança e custos da doença foram obtidos de ensaios clínicos e estudos publicados. Custos por dose e administração foram retirados de tabelas de preço oficiais. Resultados: Demonstra-se que alentuzumabe é dominante, acumulando mais QALYs (6.752) por um custo total de tratamento menor (R$ 377,9 milhões) em relação ao natalizumabe (5.652; R$ 432,9 milhões). O tratamento com alentuzumabe apresenta vantagens quanto à eficácia no longo-prazo e efetividade na redução da ocorrência de surtos e hospitalizações. A incerteza paramétrica do modelo foi analisada através de análises de sensibilidade determinística e probabilística. A análise de sensibilidade corrobora os resultados pois, mesmo com a variação de parâmetros-alvo de incerteza, o alentuzumabe ainda possui 97,8% de probabilidade de ser custo-efetivo versus o natalizumabe, considerando o limiar de 3 PIB per capita. Conclusão: Alentuzumabe é uma nova terapia custo-efetiva, provando ser alternativa economicamente viável. Análises de custo-efetividade como esta são importantes para otimizar a tomada de decisões de gestores do sistema de saúde, tanto públicos como privados.
The quantification and application of handheld energy-dispersive x-ray fluorescence (ED-XRF) in mudrock chemostratigraphy and geochemistry

Abstract Traditionally, analytical techniques such as wavelength-dispersive x-ray fluorescence (WD-XRF), inductively-coupled plasma (ICP) and mass spectrometry (ICP-MS), instrumental neutron activation analysis (INAA), or stationary (bench-top) energy-dispersive x-ray fluorescence (ED-XRF) have been used to generate quantitative geochemical results. However, a more efficient means of data collection using portable ED-XRF instrumentation now allows the investigator to acquire rapid, non-destructive, quantitative measurements on drill core and clean, flat rock surfaces, in addition to pressed powder pellets typically used in WD-XRF analysis. Similar to traditional XRF methods, quantification using the handheld ED-XRF requires a matrix-specific calibration. Unfortunately, very few internationally-accepted mudrock or shale reference materials exist, and their elemental ranges provide inadequate coverage for the geochemical diversity of mudrocks. In order to return reliable, calibrated results, a unique set of reference materials has been developed that incorporates a wide range of mudrock elemental compositions. The current method provides elemental calibrations for major elements heavier than sodium, and the following trace elements: Ba, V, Cr, Ni, Cu, Zn, Rb, Sr, Y, Zr, Nb, Mo, Th, and U. A comparison of handheld energy-dispersive and wavelength-dispersive x-ray fluorescence (ED-XRF and WD-XRF) results from pressed powder pellets of Mississippian-age Barnett Shale of North-Central Texas, USA, is presented in order to evaluate the reliability of the reference calibration and the quantification of unknown samples using two different instrument platforms. It will be demonstrated that calibrated results from the handheld ED-XRF effectively define chemostratigraphic changes in real-time. As a consequence, quantified results can be used immediately to assess changes in bulk mineralogy, paleo-redox conditions, and to link down-core geochemical changes to stratigraphic, sedimentological, and paleoenvironmental observations.
Efficient Structured Scan Patterns Retargeting for Hierarchical IEEE 1687 Networks

The IEEE 1687 standard introduced a large design space of compliant networks for accessing embedded instruments. Such networks could grow in their structural complexity and inter-component temporal dependencies. Scan pattern retargeting is defined as the procedure of translating an instrument-level pattern to several network-level ones. Pattern retargeting could become computationally intensive with the increase of structural and temporal dependencies. Structured pattern retargeting was previously introduced as a formal and light-weight pattern retargeting methodology for arbitrary IEEE 1687 networks. In this work, we present a dedicated structured retargeting method for hierarchical IEEE 1687 networks. The proposed method significantly reduces the retargeting time for pure hierarchical networks compared to the general one, while resulting in the same network access time. The retargeting time is of a special importance in the case of on-chip retargeting, which is used for on-line monitoring using IEEE 1687 networks.
Nuclear Decommissioning Risk Management Adopting a Comprehensive Artificial Intelligence Framework: An Applied Case in an Italian Site

No abstract available.
Atmospheric gas-to-particle conversion

Atmospheric Gas-to-Particle conversion (ATM-GTP) is a 5-year project focusing on one of the most critical atmospheric processes relevant to global climate and air quality: the first steps of atmospheric aerosol particle formation and growth. The project will concentrate on the currently lacking environmentally-specific knowledge about the interacting, non-linear, physical and chemical atmospheric processes associated with nano-scale gas-to-particle conversion (GTP). The main scientific objective of ATM-GTP is to create a deep understanding on atmospheric GTP taking place at the sub-5 nm size range, particularly in heavily-polluted Chinese mega cities like Beijing and in pristine environments like Siberia and Nordic high-latitude regions. We also aim to find out how nano-GTM is associated with air quality-climate interactions and feedbacks. We are interested in quantifying the effect of nano-GTP on the COBACC (Continental Biosphere-Aerosol-Cloud-Climate) feedback loop that is important in Arctic and boreal regions. Our approach enables to point out the effective reduction mechanisms of the secondary air pollution by a factor of 5-10 and to make reliable estimates of the global and regional aerosol loads, including anthropogenic and biogenic contributions to these loads. We can estimate the future role of Northern Hemispheric biosphere in reducing the global radiative forcing via the quantified feedbacks. The project is carried out by the world-leading scientist in atmospheric aerosol science, being also one of the founders of terrestrial ecosystem meteorology, together with his research team. The project uses novel infrastructures including SMEAR (Stations Measuring Ecosystem Atmospheric Relations) stations, related modelling platforms and regional data from Russia and China. The work will be carried out in synergy with several national, Nordic and EU research-innovation projects: Finnish Center of Excellence-ATM, Nordic CoE-CRAICC and EU-FP7-BACCHUS.
Neurescuetm: computer- controlled aortic occlusion device for the treatment of cardiac arrest

With a worldwide incidence expected to increase from 9,23 million cases by 2020 to 10,89 million cases by 2030, Sudden Cardiac Arrests (SCA) episodes are today recognized as a public health problem leading to severe brain tissue damage with survival rates below 10%. Neurescue Aps (NEUR) proposes to address the SCA burden by bringing to light a game changing solution - NeurescueTM – capable of extending the critical time window necessary to bring a SCA patient back to normal heart function, and therefore holding the potential to radically improve the emergency assistance provided to SCA patients, allowing for 20- 40% of increase in the survival rate of SCA patients. Due to an algorithm-run sensor technology which enables a safe and accurate computer-controlled aortic occlusion, NeurescueTM is a portable medical device that, not only increases the blood perfusion pressure necessary for vital organs preservation (i.e. brain and heart), but also works in synergy with standard resuscitation procedures increasing their probability of success. NeurescueTM is the only device in the market that combines portability with the accuracy required for a safe medical intervention (i.e. aorta occlusion) to SCA patients both inside and outside the hospital premises. With a price-competitive technology and with an unrivalled value proposition, NEUR is in a strong position to build a profitable business. Building on the project activities, NeurescueTM the device is projected to be ready for commercial roll-out by 2021 with a predicted total aggregated revenue for the company of over €234M throughout the 5 years post- project. CAtALySt project aims to surpass the main market barriers associated with the market introduction of NeurescueTM, namely obtaining FDA clearance, gathering data for CE-marking and broad clinical demonstration for market awareness and to ensure end-user medical adoption. Pre-clinical validation will be completed at Rigshopitalet in Copenhagen, Denmark on 10 trauma patients and with Heidelberg University Hospital in Germany on 10 in-hospital cardiac arrest patients. Further international clinical evidence will be collected at a study with an avid research hospital in the US with experienced key-opinion-leaders on 10 in-hospital cardiac arrest patients.
Blue combustion for the storage of green electrical power

The detrimental consequences of global warming and the scarceness of fossil energy resources make an increasing use of renewable energy sources imperative. However, the inherent volatility of most of these energy sources requires both the installation of fast fossil backup power and large amounts of storage capacity. In the ERC funded project GREENEST the fundamentals of an ultra-wet gas turbine cycle are developed. In the proposed project BlueStep :  Blue Combustion for the Storage of Green Electrical Power, the idea of ultra-wet combustion is extended towards the demonstration of a very effective and clean energy storage and conversion technology. Excess renewable electrical energy is utilized in a high pressure electrolysis process to produce hydrogen and oxygen. Both gases are stored at high pressure and their combustion, referred to as blue combustion, can be directly incorporated in existing base load steam power plants, resulting in the BlueStep cycle. Combustion takes place in the steam cycle of the plant and the exhaust gases consist solely of steam that can further expand in the remaining stages of the closed steam cycle. Depending on the mode of application, the power output of the plant and the efficiency of the cycle can be enhanced significantly. The proposed BlueStep cycle outclasses competing technologies in terms of efficiency, flexibility, space requirements, and investment costs. In a highly conservative market sector the proposed technology offers an economical and efficient method to realize extensive energy storage. The proposal comprises two key aspects: (1) the demonstration of diluted hydrogen-oxygen combustion under engine conditions to prove the technical feasibility of the technique to future customers; and (2) the development of a thorough business plan for the construction and operation of a full scale BlueStep energy storage plant to show the high economic potential of the concept to future investors.
ASSEMBLY INCLUDING A SHOCK BEAM AND AN ABSORBER

The invention relates to an assembly including a rear shock beam (18) and a shock absorber (20). The beam and the absorber each include securing means (24, 25) to a blank frame (12) of the automobile. The absorber is adapted to absorb a corner shock and to be mounted in the vicinity of a rear corner (14) of the blank frame (12) as an extension of the beam (18) in the longitudinal direction thereof so as to provide a clearance (27) between a proximal end (28) of the beam (18) and the absorber (20).