SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Cardiac myocyte alternans in intact heart: Influence of cell–cell coupling and β-adrenergic stimulation

Cardiac alternans are proarrhythmic and mechanistically link cardiac mechanical dysfunction and sudden cardiac death. Beat-to-beat alternans occur when beats with large Ca(2+) transients and long action potential duration (APD) alternate with the converse. APD alternans are typically driven by Ca(2+) alternans and sarcoplasmic reticulum (SR) Ca(2+) release alternans. But the effect of intercellular communication via gap junctions (GJ) on alternans in the intact heart remains unknown.We assessed the effects of cell-to-cell coupling on local alternans in intact Langendorff-perfused mouse hearts, measuring single myocyte [Ca(2+)] alternans synchronization among neighboring cells, and effects of β-adrenergic receptor (β-AR) activation and reduced GJ coupling.Mouse hearts (C57BL/6) were retrogradely perfused and loaded with Fluo8-AM to record cardiac myocyte [Ca(2+)] in situ with confocal microscopy. Single cell resolution allowed analysis of alternans within the intact organ during alternans induction. Carbenoxolone (25 μM), a GJ inhibitor, significantly increased the occurrence and amplitude of alternans in single cells within the intact heart. Alternans were concordant between neighboring cells throughout the field of view, except transiently during onset. β-AR stimulation only reduced Ca(2+) alternans in tissue that had reduced GJ coupling, matching effects seen in isolated myocytes.Ca(2+) alternans among neighboring myocytes is predominantly concordant, likely because of electrical coupling between cells. Consistent with this, partial GJ uncoupling increased propensity and amplitude of Ca(2+) alternans, and made them more sensitive to reversal by β-AR activation, as in isolated myocytes. Electrical coupling between myocytes may thus limit the alternans initiation, but also allow alternans to be more stable once established.
Utility of the Heavy/Light Chain assay in the Evaluation of Complete Response to Therapy in Multiple Myeloma Patients

PO-057 Utility of the Heavy/Light Chain assay in the Evaluation of Complete Response to Therapy in Multiple Myeloma Patients J. Batini, Z. Peri, D. egulja, J. Last, S. Priji, K. Dubrav i, L. Volari, D. Serti, I. Radman, S. Ba i -Kinda, D. Mati i, D. Batini, B. Labar, D. Nemet School of Medicine, University of Zagreb, Zagreb, Croatia; University Hospital Center Zagreb, Department of Internal Medicine, Division of Hematology, Zagreb, Croatia; University Hospital Center Zagreb, Department of Laboratory Diagnostics, Clinical Unit of Special Biochemistry, Zagreb, Croatia; University Hospital Center Zagreb, Department of Laboratory Diagnostics, Clinical Unit of Cellular Immunodiagnostics and In Vitro Procedures, Zagreb, Croatia; The Binding Site Group Ltd, Birmingham, UK
Fortalecimiento de la internacionalización del producto espartano Oy

En el proyecto, Spartan Product Oy fortalecerá su crecimiento internacional como área objetivo, especialmente desde Oriente Medio. La empresa aumentará su conocimiento del mercado objetivo e identificará y formará redes de asociación que contribuirán a la realización del negocio de la empresa en el área objetivo. Durante el proyecto, la empresa desarrollará su estrategia de marca internacional y formulará su concepto de servicio teniendo en cuenta las características de la zona objetivo. Las medidas del proyecto de desarrollo permitirán la provisión de paquetes de capacitación de tamaño significativo en los países destinatarios.
Study and Investigate Effect of Input Parameters on Temperature and Noise in Gearbox Using DOE

Before make gearbox we have to verify how it will work, performance, efficiency, which factors effecting gearbox performance. Which parameters like temperature and noise. we have to find out it's effect on gearbox design before making gearbox by using modeling and/or various methods, then optimize that parameters which effects temperature and noise before making gearbox, we can also optimize our cost factor to make gearbox, And predict design for good gearbox. Hi-tech drives Pvt. Ltd. is manufacturer of Gear and Gearboxes. In Gearboxes when they are tested at that time noise and temperature limits to be taken care. Here our attempt is to apply DOE techniques to achieve desired design of gearbox for control the temperature and noise levels in gearbox.
Identifying marginal lands in europe and strengthening their contribution potentialities in a co2 sequestration strategy

Marginal Lands (MLs) could offer suitable carbon sinks by afforestation/reforestation projects without being competitive to food production, conforming to EU/Global policies. The main objective of MAIL is to trigger utilization of MLs as Carbon Sinks by activities related to forestry and agriculture. The project aims to detect and classify mountainous and semimountainous Marginal Lands (m/sm MLs), in order to deliver a web-based regional platform with data, methodology and applications which will be valuable for policy makers, stakeholders or researchers.
MAIL will assess MLs’ presence, distribution and suitability in smart and efficient way, considering that marginality differs within European bioclimatic zones. It will detect MLs through multiple layer analysis of existing EU/Global scale datasets (land cover, land use, soil or climatic information, etc.) and will further examine, validate and classify MLs, through field stratified sampling, into Carbon sequestration capacity categories.
In pilot areas MAIL will augment the achieved accuracy by using enhanced spatial and radiometric resolution of full free and open access satellite datasets. Furthermore, it will propose actions that have to be taken in order to increase Carbon sequestration capacity and it will evaluate their feasibility by using a set of criteria for accurate cost estimation. Finally, it will deliver developed methodologies, algorithms and techniques on a web-application platform for on-demand production of thematic maps within Europe.
MAIL consists by a multidisciplinary Consortium of 6 experienced partners, from 4 EU Member States, and gathers the expertise required for identifying, mapping and assessing MLs as a potential Carbon Sinks. The seconded staff will exchange individual skills, competencies, thoughts, innovations, or ideas and through collaboration will acquire new skills concerning MLs management and will become more flexible, productive and efficient.
Carrier mobility does matter for enhancing thermoelectric performance

Excellent thermoelectric materials need both high carrier transport properties and low phonon transport properties simultaneously, which make it challenging to enhance thermoelectric performance. However, recent progress shows that sub-nanostructures can strongly intensify phonon scattering but scarcely impede carrier mobility, thus effectively contributing to high thermoelectric performance in PbTe/Se-based systems. In this perspective, we summarize the thermoelectric transport properties and internal atomic-scale structures in these PbTe/Se-based systems with sub-nanostructures. Then, their thermoelectric properties are comprehensively compared with other massively nanostructured PbTe/Se-based systems, reveling the favorable role of sub-nanostructures in achieving high carrier mobility. Finally, several other potential strategies to further maintain carrier transport properties and enhance thermoelectric performance are proposed, which might be extended to other thermoelectric systems.
Narrow Band Imaging Cystoscopy and Bipolar Plasma Vaporization for Large Nonmuscle-invasive Bladder Tumors—Results of a Prospective, Randomized Comparison to the Standard Approach

To evaluate the efficacy of narrow band imaging (NBI) cystoscopy associated with bipolar plasma vaporization (BPV) in cases of large nonmuscle-invasive bladder tumors (NMIBTs) compared with white light cystoscopy (WLC) and monopolar transurethral resection of bladder tumors (TURBTs).A total of 220 cases with ≥ 1 bladder tumor >3 cm determined by abdominal ultrasonography, computed tomography, and flexible WLC were included in the present trial. The patients in the first arm underwent WLC and NBI cystoscopy followed by BPV, and the patients in the second arm underwent only WLC and TURBT. The patients with NMIBTs underwent standard repeat TUR at 4 weeks and follow-up urinary cytology and WLC at 3, 6, 9, and 12 months.The carcinoma in situ, Stage pTa, and overall NMIBT detection rates were significantly improved for NBI compared with WLC. BPV provided lower obturator nerve stimulation and bladder wall perforation rates and significantly reduced the mean hemoglobin decrease, catheterization period, and hospital stay compared with TURBT. The repeat TUR overall and primary site residual tumor rates were significantly decreased in the NBI-BPV group (6.3% vs 17.5% and 4.2% vs 13.4%, respectively). The overall and other site 1-year recurrence rates were significantly reduced in the NBI-BPV series (7.9% vs 17.8% and 3.4% vs 12.2%, respectively).NBI cystoscopy significantly improved the diagnostic accuracy in cases of large NMIBTs, and BPV emphasized superior efficacy and safety compared with TURBT. This combined approach provided a lower residual tumor rate at repeat TUR and a reduced 1-year recurrence rate.
Comment utiliser la démarche champ-école pour accompagner les transitions agroécologiques des agricultures familiales des pays du Sud?

Comment utiliser la démarche champ-école pour accompagner les transitions agroécologiques des agricultures familiales des pays du Sud?Recommandations pour les facilitateur.rice
Barron's IELTS: International English Language Testing System

The IELTS test is used as a measure of English language proficiency by over 7,000 educational institutions, government departments and agencies, and professional organizations in 135 countries. This updated manual for ESL students covers all parts of the IELTS and all of its question types: multiple-choice, short answer, sentence completion, flowchart completion, graphs, tables, note taking, summarizing, labeling diagrams and maps, classification, matching, and selecting from a list. It also presents-- Four practice Academic tests that reflect the most recent actual tests Two practice General Training tests Audio for all tests and activities on the enclosed audio CDs Explanatory answers for all test questions, including listening and reading modules with answer keys Also included are answer sheets and an audioscript for the listening sections.
TRANSPORT LOCK, IN PARTICULAR FOR THE PISTON OF A CLUTCH RELEASE BEARING

The invention relates to a transport lock for a clutch release system, in particular for a slave cylinder of a motor vehicle, an axially movable piston and a clutch release bearing that is connected to said piston being arranged concentrically on a housing. According to the invention, in order to lock the piston or the clutch release bearing during transport, a retaining ring which has a collar that extends outwards in a radial direction and which is secured on the housing in an inner cavity of the clutch release bearing is provided. A contact surface of the piston lies against the collar of the retaining ring in such a way that the retaining ring restricts the axial movement of the piston.
Desenvolver um algoritmo que otimiza o processo de combinação de investimentos com investidores através de ofertas de criação de perfis usando no setor imobiliário

SA 42799(2015/X) Como parte do projeto, será desenvolvido um algoritmo para otimizar o processo de definição de perfis de investimento e, assim, modernizar o serviço de seleção de investimentos para investidores interessados no mercado imobiliário. A tecnologia criada no âmbito do projeto será implementada para modernizar os serviços prestados pelo requerente — serviços de intermediação em investimentos imobiliários. O objetivo do trabalho de investigação e desenvolvimento é analisar as fontes de dados sobre transações e investimentos realizados, dar prioridade e dar prioridade a categorias individuais e desenvolver um algoritmo pronto a implementar para a definição de perfis dos utilizadores e das suas ofertas. O algoritmo resultante, ganza na análise morfológica e fatorial, melhorará os processos de prestação de serviços atualmente empreendidos pela Parte Ordenadora e, com base nos dados recolhidos e nas análises realizadas, criará a forma mais ótima de chegar ao investidor através da definição de perfis e da utilização de ferramentas de oferta adequadas em diferentes momentos.
[Clinical application of M-CHAT and CHAT-23 for autism screening].

To analyze and compare Modified Checklist for Autism in Toddlers (M-CHAT) and Checklist for Autism in Toddlers-23 (CHAT-23) in terms of clinical applicability, and to provide a basis for the understanding of early specific clinical manifestations of children with autism.A total of 350 children aged 18-36 months who visited the Department of Developmental Pediatrics of Shengjing Hospital of China Medical University were enrolled as subjects. Of the 350 children, 284 who had not been previously diagnosed with autism were screened according to the two checklists. Sixty-eight confirmed cases of autism (including two of the 284 screening subjects diagnosed with autism) were assigned to the autism group, and 278 of the 284 screening subjects (except six children diagnosed with autism, mental retardation or cerebral palsy) were assigned to the control group. The two groups were compared with respect to the positive rate for each item in the checklists. The efficacy of the M-CHAT and CHAT-23 assessment criteria was evaluated by comparative analysis.The autism group showed the highest positive rate for Item 9. There were significant differences between the two groups in terms of the positive rates for all items except Item 16 (P<0.05). When the assessment criterion was that autism was confirmed if there were positive results for at least 3 of a total of 23 items, M-CHAT showed the lowest rate of missed diagnosis (0%); when the assessment criterion was that autism was confirmed if there were positive results for at least 6 of a total of 23 items, CHAT-23 showed the lowest rate of misdiagnosis (1.77%). The specificity of M-CHAT is lower than that of CHAT-23 (P<0.05). There was no significant difference in sensitivity between the two checklists (P>0.05).CHAT-23 is more suitable than M-CHAT for clinical autism screening due to higher specificity, as well as having the advantages of low cost, easy completion,high efficiency and easy result judgment.
A decision-making approach to field service delivery under mixed maintenance policy

Maintenance service delivery for large-scale equipment has been studied for decades and is becoming a crucial way for equipment manufacturers to obtain profit and competitiveness. To delivery maintenance service, equipment manufacturers need to optimal delivery plans with considering of various constraints (e.g. maintenance policy, service capacities, service costs) as well as maintenance type. This study proposed a mathematical model and algorithm-based approach to solving a maintenance service decision-making problem in the mixed maintenance policy context and to assess its performance. The mathematical model was constructed with the constraints of technician number, skill level, maintenance time windows, and maintenance policy. A hybrid algorithm of simulated annealing algorithm (SA) and genetic algorithm (GA) is proposed to solve this practical maintenance service delivery problem. A case study of agricultural equipment maintenance demonstrated that the proposed methods are effective and the algorithms can provide reasonable solutions within an acceptable computational time. Our approach is effective and can be utilized to improve the performance of maintenance service decision-making for the mixed policy.
Adding events to a calendar from another application

A method and apparatus is provided that allows a user to automatically add content, such as an event, to a container, such as, a calendar without directly accessing the container. Second and third preferred embodiments are also provided.
Cutting edge training - cutting edge technology

EDGE is a training and development programme of scientific excellence for postdoctoral researchers that offers a unique combination of disciplines and industry engagement to the 71 fellows it will recruit. Leveraging the strengths and assets of three Irish National Research Centres, AMBER, CONNECT and ADAPT, headquartered in TCD, EDGE will form the next generation of thought leaders in ICT. AMBER offers expertise in advanced materials that will play a pivotal role in future systems and devices. CONNECT’s focus is on future networks that will underpin the services the world needs and ADAPT brings cutting-edge expertise in digital content. EDGE researchers will work at the interface between these Centres and will generate highly interdisciplinary projects, adding value to all. Most importantly, industry will have a primary role in defining, running and supporting the projects, and will take an active part in developing the scientists, through secondments, industry events and specialised training. 
Applying the principles of the Charter and Code throughout the programme, the EDGE selection process is guided by the principles of Excellence, Transparency, Fairness and Impartiality. Candidates will submit proposals and fellows will be selected following an open, transparent, merit-based, impartial and equitable selection procedure, based on international peer review. EDGE offers the possibility of building skills that will address a clearly identified skills shortage across Ireland and Europe.
EDGE will impact Europe through the development of a unique cohort of excellent, cross-disciplinary fellows who will have the capability of managing multidisciplinary, industrial research problems. On completion of their fellowship they will have the skillset to enter the European workforce to deliver innovation and enhance European Industrial Competitiveness across the entire spectrum from materials to content.
DETERMINATION OF ELECTRONIC DISTANCE MEASUREMENT ZERO ERROR USING KALMAN FILTER

Kalman filter has gained popularity in the adjustment of field measurements since it was invented in 1960. Unlike the least squares technique it is relatively not renowned in the adjustment of surveying measurements. This work presents how it can be used in the determination of the electronic distance measurement zero error. First the values of the unknown parameters and their corresponding covariances are predicted. Subsequently, updates on the predicted parameters and covariances are estimated in several iterations. The residuals are estimated to determine the accuracy of the experiment. The estimated electronic distance measurement zero errors for three epochs are 0.015033522833m, 0.0113142487320m and 0.0113121989063m.
Computational microscopy of crowded membranes

Cell membranes form a highly complex and heterogeneous mixture of membrane proteins and lipids. Understanding the protein-lipid interplay that gives rise to the lateral organisation principles of cell membranes is essential for life and health. Thus, investigations of these crowded membranes is emerging as a new and exceptionally exciting frontier at the crossroads of biology, life sciences, physics, and chemistry.

However, our current understanding of the detailed organisation of cellular membranes remains rather elusive. Characterisation of the structural heterogeneity in-vivo remains very challenging, owing to the lack of experimental methods suitable for studying these fluctuating nanoscale assemblies of lipids and proteins with the required spatio-temporal resolution. In recent years, computer simulations have become a unique investigatory tool for understanding the driving forces governing the lateral organisation of cellular membrane components and this “computational microscopy” has become indispensible as a complement to traditional microscopy methods.

In this ERC project I will, using advanced computational microscopy, study the interaction of lipids and proteins in complex, crowded, membrane patches, to enable the driving forces of membrane protein sorting and clustering to be unravelled at conditions closely mimicking real cellular membranes. The specific objectives are:

• To develop a novel computational microscopy framework for simulating biomolecular processes at multiple resolutions.
• To use this new computational microscopy framework to investigate the driving forces of membrane protein sorting and clustering.
• To provide a molecular view of realistic, crowded, biological membranes composed of hundreds of different lipids and proteins.

The outcomes will enable subsequent studies of many different types of cell membranes based on forthcoming lipidomics studies and progress in structural characterisation of membrane proteins.
Marbling in the longissimus thoracis muscle from lean cattle breeds. Computer image analysis of fresh versus stained meat samples

One hundred eighty ribeye steaks from Charolais, Limousin and Retinta bulls were used to describe and compare the marbling fat between fresh and stained samples. Image analysis overestimated the intramuscular fat content (P<0.05) in relation to chemical analysis. Staining had a significant effect (P<0.05) on most of the marbling fleck traits, showing an increase in the number of marbling flecks and the proportion of marbling fleck area in the whole and in the ventral half of the longissimus m., and a decrease in the size, length and width of marbling flecks. Breed had a significant influence (P<0.05) on some quantity traits of marbling, but not in the distribution and structure of marbling flecks (P>0.05). Retinta breed was leaner than French breeds and showed fewer and smaller marbling flecks (P<0.05). The results showed a positive correlation (r=0.183 to 0.465) between USDA marbling score, and intramuscular fat by image and chemical analysis.
Factors Affecting Economic Growth in Africa: Are There any Lessons from China?

Since generating sustained economic growth in Africa remains one of the most pressing challenges to development, it is imperative that Africa-specific determinants of economic growth are investigated. At the same time, in spite of recent slight slowdown, China's economic growth and its capacity to move in thirty years from underdevelopment and extreme poverty to an emerging global economic power had attracted the attention of many developing countries, including those in Africa. Some key questions arise: Can China serve as a growth model for Africa? And what lessons can we draw from the Chinese experience of soaring economic growth? We therefore investigate the determinants of economic growth in Africa (North and sub-Saharan Africa), using an Africa-only sample with five non-overlapping three-year averages of cross-sectional data between 1996 and 2010. We also do the same for China for the period, 1980 to 2010, while discussing recent trade, investment and aid/debt relations between Africa and China. Our results suggest that domestic investment, net ODA inflows, education, government effectiveness, urban population, and metal prices positively and significantly affect Africa's economic growth. For China, the key factors driving its economic growth are domestic investment, trade openness, initial income, and rural share of the population. Factors driving down China's growth include inflation rate, domestic credit to the private sector, net ODA inflows, population growth, telephone density, and oil and agricultural/raw materials prices. One key finding is that while Africa is almost twice as open as China, openness does not positively and significantly affect Africa's growth, unlike in China. A principal source is that Africa imports (mainly consumer goods) more than it exports while the reverse is true for China. Moreover, the structure of Africa's exports is biased towards traditional primary commodity exports unlike China that has rapidly shifted towards manufactures. In addition, Chinese domestic investment is about double that of Africa. The key lessons for Africa from the soaring Dragon's experience are discussed.