SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Multi-Omics research applied to human ada2 deficiency and beyond

Human adenosine type 2 (ADA2) deficiency is a rare but devastating condition resulting in a complex phenotype of vasculitis (ranging from cutaneous to intracerebral vasculitis with lacunar infarcts), immunodeficiency (recurrent bacterial or viral infections), bone marrow anomalies (cytopenia, aplasia),  cancer (lymphoma, leukemia). Mortality is 10%, often in childhood. The mainstay of treatment consists of anti-TNF blockade for vasculitis. Cytopenia and immunodeficiency respond poorly. Hematopoietic stem cell transplantation is curative in most cases. Although the condition was described in 2014, its pathophysiology is unsolved.  From previous work in my laboratory, I have gained insight that ADA2 is likely to play a significant role in antiviral host defense and endothelial function. I thus hypothesize that ADA2 deficiency is an underdiagnosed condition and that complete or partial ADA2 deficiency plays a role in several other common medical conditions. With this research proposal, I aim (1) to unravel the pathophysiology of ADA2 deficiency, to (2) study the significance of ADA2 deficiency in phenocopies of the disease (3) to study the function of ADA2 in vitro (4) to develop new treatment strategies for ADA2 deficiency and its phenocopies. To achieve these aims I will study the prevalence of ADA2 deficiency in cohorts of patients presenting with one or more of the main disease characteristics (e.g. juvenile stroke, aplasia, childhood lymphoma...) by genetic and functional approaches. The genotype, immunophenotype and clinical characteristics of these patients will be studied using the newest technologies.  In cell lines and tissue samples of ADA2 deficient patients, we will study the function of ADA2. Finally, we will screen known and novel drugs for their potential use in ADA2 deficiency and phenocopies, even beyond, in cardiovascular disease, cancer, anti-viral host defense.
Vorrichtung zum Bearbeiten von Blattgut

In einer Banknotenbearbeitungsmaschine werden Banknoten (100) mittels eines Transportbands (2) durch zwei Komponenten (41, 42) einer Prüfeinrichtung (40) hindurchgeführt. Das Transportband wird zumindest teilweise mittels Umlenkrollen von der Prüfeinrichtung weggeführt, um eine bessere Überprüfung der Banknoten sowie einen störungsfreien Transport der Banknoten zu ermöglichen.
Artificial intelligence for customer service

Userbot provides Artificial Intelligence for Customer Service. We have developed an innovative technology platform based on Machine Learning, Deep learning, Artificial Intelligence and Sentiment Analysis to interact with customers in a natural language on every digital channel. Userbot’s proprietary AI technology that reached TRL7 is developed internally and we are constantly improving it. We are currently working on the automation of customer acquisition and payments, as well as developing a special Agency dashboard. The basic AI remains one of the main areas of investment, optimizing and simplifying the AI model Training and improving the performance of Natural Language Processing. Our team is composed by seasoned experts with commercial and management experience, supported by 4 advisors with decades of experience in the sector. The Milan Polytechnic as partner and shareholder, allows us direct access to technology transfer to artificial
intelligence research.
Our success has already been remarkable. In the first 3 months of operation, we received numerous responses, in the Finance, Banking and Insurance sectors, as well as from Startups, SMEs and Public Authorities. Our service is currently used by companies such as Agos, Moovenda, Buzzoole, LeCicogne and PAs such as Regione Emilia Romagna and the Sesto Fiorentino Municipal Authority. In September 2017, we won the Artificial Intelligence Worldwide Software Vendor Selection, from more than 300 Startups and technology companies already established at international level and were awarded a contract with Agos Ducato S.p.A. Financially we can count on over half a million euros of investments. In March 2018, we achieved a capital increase of € 300,000 with some Business Angels that became part of the shareholders; whilst in July 2018, the equity crowdfunding on Crowdfundme raised € 200,000, with the entry of 131 new shareholders. The SME instrument phase 1 project is thoroughly aligned to Userbot’s strategy.
Simulated majorana states

Quantum computation using topologically protected Majorana bound states is a promising direction towards scalable quantum architectures due to their inherent noise immunity provided by the nonlocal storage of quantum information. Thus far, Majorana states have mostly been investigated in superconductor-semiconductor heterostructures which rely on induced superconductivity in a quasi-one-dimensional conductor. However, despite tremendous efforts in material development, these devices are still limited by uncontrolled local fluctuations due to disorder and it is unclear if future developments will solve these problems. Furthermore, disorder may even mimic the transport signatures of topological ordering, hindering an unambiguous identification of the Majorana states.
Here I propose a way to overcome these limitations: I will work towards the direct quantum simulation of the one dimensional topological superconductor with Majorana bound states. I will use chains of semiconductor quantum dots, which is an emerging platform to simulate exotic many-body electron states. Building on this platform, I will be able to demonstrate for the first time the emergence of coherent, non-local superconducting states bound to the entire device similarly to the Kitaev chain model of topological superconductivity.
To demonstrate quantum coherence of the chain, we will build the first Andreev molecule quantum bit, which, while not topologically protected, will already combine advantages of superconducting and semiconductor qubits. Going one step further, we will investigate the simulated Kitaev chain. Upon establishing the presence of the simulated Majorana states, we will work towards a simple braiding protocol to demonstrate the non-Abelian nature of the edge modes.
This research direction, combining the scalability of semiconductor structures and the topological protection of Majorana states, will open new avenues towards universal quantum computation.
Probing the mysteries of sweet “on-off” switches of the human immune system: toward the development of novel glycomimetics against bacterial infections

Glycans are directly involved in the normal physiology and in the etiology of several major diseases, spanning from bacterial and viral infections through to cancer and autoimmune disorders. Thus, deciphering the glycome holds huge promise to provide new targets and diagnostics for human health. 

Despite the tremendous advance of knowledge in the field of Glycoscience during the last decade, the comprehension at high resolution of the molecular basis of many pathogen-mediated diseases is still incomplete. 
GLYCOSWITCH will significantly contribute to fill this gap, providing a holistic picture of the manifold mechanisms of host responses to microbial infections, with a special focus on Gram-negative bacteria. I propose to address bacterial glycans recognition by host immune proteins by using a multidisciplinary approach, combining state-of-the-art synthetic organic chemistry, molecular biology, biochemistry and biophysics techniques, massively including NMR spectroscopy. I will apply them in an innovative integrated chemical biology approach in order to decipher key glycan recognition aspects beyond current knowledge. Understanding of molecular mechanisms of detection of invasive virulent bacteria by host organisms will allow to reach the ultimate goal of GLYCOSWITCH project: the design and development of novel and effective glycomimetics able to modulate the function of host immune receptor proteins. 

The success of GLYCOSWITCH will unlock attractive opportunities for the development of host-directed strategies to boost the immune response or reverse pathogen-induced immunosuppression.

My unique approach to this project, as an organic chemist with wide expertise in NMR and bacterial glycans, will provide groundbreaking information on protein-glycan interaction systems of paramount importance in biology and biomedicine, opening new avenues for approaching bacterial diseases and their secondary effects.
Local Orientation and the Evolution of Foraging: Changes in Decision Making Can Eliminate Evolutionary Trade-offs

Information processing is a major aspect of the evolution of animal behavior. In foraging, responsiveness to local feeding opportunities can generate patterns of behavior which reflect or "recognize patterns" in the environment beyond the perception of individuals. Theory on the evolution of behavior generally neglects such opportunity-based adaptation. Using a spatial individual-based model we study the role of opportunity-based adaptation in the evolution of foraging, and how it depends on local decision making. We compare two model variants which differ in the individual decision making that can evolve (restricted and extended model), and study the evolution of simple foraging behavior in environments where food is distributed either uniformly or in patches. We find that opportunity-based adaptation and the pattern recognition it generates, plays an important role in foraging success, particularly in patchy environments where one of the main challenges is "staying in patches". In the restricted model this is achieved by genetic adaptation of move and search behavior, in light of a trade-off on within- and between-patch behavior. In the extended model this trade-off does not arise because decision making capabilities allow for differentiated behavioral patterns. As a consequence, it becomes possible for properties of movement to be specialized for detection of patches with more food, a larger scale information processing not present in the restricted model. Our results show that changes in decision making abilities can alter what kinds of pattern recognition are possible, eliminate an evolutionary trade-off and change the adaptive landscape.
An Institutional Explanation for Economists’ Theoretical and Methodological Choices

ABSTRACTScientific research in general and economics research in particular is a social act. More specifically, schools of economic thought as well as associations, research groups and conferences are expressions of social organizations within the realm of economics. Historically, studies investigating the methodologies used in economics have focused on the strengths of these social organizations. This study aims to analyze the key roles played by individuals within social organizations in building and reinforcing economics and, in turn, their influence on these individuals. To achieve this goal, we use an institutionalist approach in a broad sense. We show how economics as an academic environment can be presented as an institutional entanglement and how an institutionalist approach can enhance an understanding of why economists adopt a particular theoretical and methodological perspective. It is argued that habits, observations and cognitive abilities should be seriously considered to understand the logi...
Smart forwarder for sustainable and efficient forest operation and management

Forest biomass is currently one of the most important source of renewable energy and accounts for almost half of the EU’s total renewable energy consumption. In addition to raw materials, forests also provide a wide range of vital non-wood services that should be protected during wood extraction. The innovation project Forwarder2020 has the main aim of improving sustainability of wood production and delivery as well as operational forest management and planning through the development of specific modules for more efficient forwarders (wood extraction and transportation vehicles):
• hydrostatic-mechanical power-split transmission 
• hydro-pneumatic suspension of the forwarder 
• hybrid hydraulic system for driving the crane with double recuperation of the potential energy 
• bogie axle with three instead of two driven wheels at each side to be mounted under the timber load
• monitoring system for transparency and documentation of process data like machine data, static and dynamic load over time and position 
The combined effect of these five innovations applied to forwarders will have the following impact:
• lowering of the dynamic wheel load by 25% over the same forwarder without suspension at same payload and speed. 
• reduction of rut depths by 50% 
• lowering fuel consumption while driving over the existing hydrostatic transmissions by 30% 
• making long hauling distances more economic by the efficiency of the power-split transmission 
• lowering fuel consumption while loading and unloading due to the double recuperation of the potential energy of the crane mass by 30%. 
• more precise planning of the tracks and documentation of the loads carried on the specific part of the track 
• supplying to the market a unique and modular system of high-end solutions above the competitors, where the customer can make his choice of equipment and bear no higher costs for the modules not chosen.
• bring consortium partners and thus Europe to a strong position on markets
Functional biology of hepatic cd8+ t cells

CD8+ T cells have a key role in eliminating intracellular pathogens and tumors that affect the liver. The protective capacity of these cells relies on their ability to migrate to and traffic within the liver, recognize pathogen- or tumor-derived antigens, get activated and deploy effector functions. While some of the rules that characterize CD8+ T cell behavior in the infected and cancerous liver have been characterized at the population level, we have only limited knowledge of the precise dynamics of intrahepatic CD8+ T cell conduct at the single-cell level. In preliminary data for this project we have developed several advanced imaging techniques that allow us to dissect the interactive behavior of CD8+ T cells within the mouse liver at an unprecedented level of spatial and temporal resolution. We predict that this approach, combined with unique models of hepatitis B virus pathogenesis and a new model of hepatocellular carcinoma created ad hoc for this proposal, will generate novel mechanistic insights into the spatiotemporal determinants that govern the capacity of CD8+ T cells to home and function in the virus- or tumor-bearing liver. Specifically, we plan to pursue two main goals: 1) To assess how the anatomical, hemodynamic and environmental cues that characterize hepatocellular carcinomas shape CD8+ T cell behavior and function; 2) To characterize intrahepatic T cell priming events that induce functionally defective T cell responses. Results emerging from these studies will advance our knowledge on how adaptive immunity mediates pathogen clearance and tumor elimination. This new knowledge may lead to improved vaccination and treatment strategies for immunotherapy of infectious diseases and cancer.
Comparison of radiation dose between different fluoroscopy systems in the modern catheterization laboratory: Results from bench testing using an anthropomorphic phantom

Variations in radiation dose between various X-ray systems have received limited study.We examined the impact of X-ray system type on patient radiation dose during cardiac catheterization.An anthropomorphic phantom was used in a series of standardized experiments that involved 15 sec of continuous cineangiography in 7 projections. Three to seven experiments were performed in four commonly used X-ray systems: Innova IGS (GE Healthcare), Integris Allura FD20 (Philips), Allura Clarity (Philips), and Artis one (Siemens). Phantom radiation dose was measured with a dedicated X-ray dosimetry system (Gafchromic radiology film and Film QA XR software, Ashland) that was precalibrated at 0, 1, 2, 3, and 4 Gray, and with the X-ray system built-in functions.Radiation dose was lowest with the Allura Clarity system [average film dose 4.2±0.1 cGray, peak film dose 18.3±1.6 cGray, Air Kerma (AK) dose 0.310±0.002 Gray, Dose Area Product (DAP) dose 23.72±0.84 Gray*cm2], intermediate with the Integris Allura FD20 (average film dose 4.4±1.1 cGray, peak film dose 29.4±15.5 cGray, AK 0.482±0.189 Gray, DAP 45.18±21.90 Gray*cm2), and highest with the Artis one system (average film dose 7.4±0.8 cGray, peak film dose 66.9±0.09 cGray, AK 0.746±0.085 Gray, DAP 75.93±9.11 Gray*cm2) and the Innova IGS system (average film dose 7.2±1.0 cGray, peak film dose 49.3±28.9 cGray, AK 0.874±0.340 Gray, DAP 92.28±14.73 Gray*cm2; P=0.011 for average film dose, P=0.019 for maximum film dose, P=0.033 for AK, and P=0.008 for DAP).The X-ray system type has significant impact on patient radiation dose during cardiac catheterization.
APPARATUS AND METHOD FOR HYDROENHANCING FABRIC

An apparatus (10) and related process for enhancement of woven and knit fabrics through use of dynamic fluids which entangle and bloom fabric yarns. A two stage enhancement process is employed in which top and bottom sides of the fabric are respectively supported on members (22), (34) and impacted with a fluid curtain including high pressure jet streams. Controlled process energies and use of support members (22), (34) having open areas (26), (36) which are aligned in offset relation to the process line produces fabrics having a uniform finish and improved characteristics including, edge fray, drape, stability, abrasion resistance, fabric weight and thickness.
Expansion of the hotel’s service base at Śnieżnik and introduction of paramedical and rehabilitation services as a response to the negative effects of the COVID-19 outbreak

The subject of the project is the expansion of the service base of the Hotel near Śnieżnik and the introduction of paramedical and rehabilitation services as a response to the negative effects of the COVID-19 outbreak. The implementation of the project will allow the creation of a new infrastructure of the Hotel near Śnieżnik located in Bolesławowo and the extension of the current hotel, catering and wellness offer to include paramedical and rehabilitation services. The applicant, implementer and coordinator of the project will be the Company Geotrade Sp. z o.o., which is the owner and manager of the Hotel near Śnieżnik and Apartments near Śnieżnik. Hotel and catering activity was launched in the Applicant Company in 2011 as a diversification of the main activity, which was geological and engineering activities. Currently, the main activity of the Applicant is the hotel activity, which is confirmed, among others, by the entry in the REGON and KRS register confirming that the predominant activity concerns code PKD 55.10 (hotels and similar accommodation facilities). The implementation of the project involves the expansion of the outdoor part of the hotel by 3 protective roofs: 2 with an area of approx. 50 m² and 1 with an area of approx. 35 m². In addition, it is planned to create a terrace area for a Finnish sauna and a balloon. The investment will be complemented by the installation of the photovoltaic system on the roofs of protective roofs as an alternative source of energy both for the created infrastructure and for the needs of the entire facility. The contractors of the project will be selected during the competitive procedure, and the project will be led by the Members of the Management Board and the staff of the Hotel. The project will be located in Bolesławowo, the municipality of Strona Śląskie on a plot belonging to Geotrade. Plot 110/12 covers an area of 0.3965 hectares and is partly built up by the Hotel building near Śnieżnik. The area is marked with the symbol BI other built-up areas. This plot is currently a green area undeveloped, and there is a possibility of direct passage from the Hotel
Robust self-testing with applications to device-independent cryptography

The quantum revolution is happening now. Every day experimentalists around the world produce more complex, reliable and powerful quantum devices which take us one step closer to quantum computation, communication and cryptography. Testing is a crucial part of the development process necessary to ensure suitability of the device for the application in mind. Methods used for small devices quickly become impractical, as the devices become more complex and we need to develop efficient and robust testing procedures in order to make further progress. Fortunately, quantum physics is well-suited for this task, as it allows to precisely characterise devices under surprisingly weak assumptions. This feature, known as self-testing, is intrinsically related to the fundamental concept of Bell inequalities. The goal of this proposal is to develop efficient and robust testing procedures for complex quantum devices based on Bell's theorem. In the short-term these will allow experimentalists to efficiently characterise their devices, while in the long-term they will enable a customer to certify that a newly bought quantum device adheres to the specification, which opens the door to device-independent information processing. The timeliness of this proposal is demonstrated by the fact that the first loophole-free Bell experiments were reported within the last year. On top of practical applications, self-testing is important from the foundational point of view. By exploring the intimate connection between the quantum (microscopic) world of Hilbert spaces and the classical (macroscopic) world of resulting probability distributions, it provides the unique link between what we see and what is happening at the quantum level. This fellowship will allow Jędrzej Kaniewski to work under the supervision of Matthias Christandl (a world-class expert on quantum correlations) at the University of Copenhagen (a leading institution in both theoretical and experimental aspects of quantum mechanics).
An Efficient Data Parallelization of the Radix-23 (Carbon) FFT on GPU/CPU

Solving Complex Problem that is coupled with intensive workloads; necessities the access to a massively parallel computational power. Up to date, Graphic Processing Units (GPUs) are the only architecture that could handle the most complex computationally intensive workloads. In the light of this rapid-growing advancement in computational technologies, this paper will propose a high-performance parallel radix-23 FFT suitable for such GPU and CPU systems. The proposed algorithm could reduce the computational complexity by a factor that tends to reach p r if implemented in parallel (pr is the number of cores/threads) plus the combination phase to complete the required FFT.
Promoção da empresa BALT-YACHT através da participação em feiras internacionais da indústria naval

O objeto do projeto é a promoção da empresa «BALT-YACHT» K.A. I B. Kozłowscy SPÓŁKA JAWNA nas feiras de exposições realizadas em Katowice e Lelystad (Países Baixos). Ao participar na feira, o efeito pretendido seria alcançado, ou seja, a promoção da empresa e da própria região em mercados fora dos mercados regionais e internacionais. O beneficiário é uma média empresa. Execução do projeto — 1.ª feira em 5-9 de setembro de 2018; 2a feira de 12 a 14 de outubro de 2018. O principal objetivo que a empresa quer realizar é a promoção em feiras internacionais, que ampliarão as oportunidades de exportação da empresa e fortalecerão sua posição no mercado suprarregional. Destina-se igualmente a aumentar a exportação de iates para os mercados internacionais, em especial para os mercados europeus. Tarefas específicas: — visita à Feira do Vento e da Água realizada em Katowice em 12-14 de outubro de 2018 como expositor — uma viagem à feira internacional HISWA nos Países Baixos em 5-9 de setembro de 2018 como expositor de Indicadores de Produto: — Número de empresas que recebem apoio: 1 — Investimentos privados complementares ao apoio público às empresas: 30 773,64 PLN Indicadores de resultados: — Aumento das vendas de exportação — 1 % até 2020.