SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Cooperative, greener, multivendor cognitive software to maximize the performance of next-generation wireless networks

In a wireless world, where users and things demand a growing hyper-connectivity, offering a quality WiFi service for final users is almost impossible. This is due to the fact that the current trends promote a captive market and vendor lock-in.
Nobody is facing effectively the problem of high-density, high-interfering, next-generation WiFi networks. Galgus has come to solve this problem, by disaggregating WiFi optimization and management software from hardware, pursuing a collaboration paradigm for APs (Access Points). The technology proposed in ECOWIFI solves the pains of the main players in this sector: Network Owners (easy and affordable operation, maintenance, updating, and analytics), System Integrators (vendor-independence and optimization), and Hardware Manufacturers (cost of developing their own research lines).

We have created Cognitive HotspotTM Technology (CHT), a patented, multiplatform, and distributed embedded software for WiFi devices, in order to optimize resources and to bring intelligence to the network. We have shown 12x performance improvement with the same hardware (up to 98% cost reduction), and 2x performance with less hardware (up to 80% cost reduction). CHT pursues a cooperation paradigm for WiFi.

Galgus plans to scale up globally by consolidating CHT as best-class technology for WiFi optimization in the niche markets of connected transport and industry, where there is few competition. The SMEi2 will allow Galgus to position Galgus as Industry Leader in front of the main stakeholders in the value chain. This will allow the company to accelerate its market entry and achieve sales of approx. 30.9 M€ in 2023, with an accumulated net margin of 23.5 M€.
Learning gaps in criminal justice system in norway

GAPSLE is an interdisciplinary project studying criminal justice system (CJS) in Norway. It recognises the need to go beyond individual skill-based learning and promotes development of collaborative learning as a way to find new innovative ways of working, increase staff’s work-based well-being and reduce reoffending rates in prisons. The underlaying rationale is contributing to making the EU a more secure society.
The approach is to  (1) empirically explore the current state of collaborative learning activities nationally by interviewing professionals across CJS and analysing documents, (2) empirically explore tensions around collaborative learning  by interviewing professionals across CJS, (3) conduct a survey and develop an assessment tool to chart CJS practitioners’ readiness for collaborative learning and (4) develop a strategy to support collaborative organizational learning activities among different occupational groups and creation of social innovations within CJS. 
Cultural-historical activity theory and expansive learning give the theoretical framework for the study. Their strength is to allow going beyond individuals and to take into account larger contextual and systemic activity (e.g. organizational structures, rules, community) when analysing learning and activity. Methodologically they provide with established methods to analyse need state (readiness) and tensions within an activity.
The expected outcomes will be exploited by practitioners, educators and decisionmakers within CJS to support in reviewing and designing learning events and strategies, and academics in the field of workplace learning to develop methodologies. Furthermore, they are expected to raise interest among layperson who have interest towards prison work, prison services and issues contributing to a safer society.
Study on the E-commerce platform based on the agent

To solve problem of dynamic integration in e-commerce, the Multi-Agent architecture of electronic commerce platform
system based on Agent and Ontology has been introduced, which includes three major types of agent, Ontology and rule
collection. In this architecture, service agent and rule are used to realize the business process reengineering, the reuse of
software component, and agility of the electronic commerce platform. To illustrate the architecture, a simulation work
has been done and the results imply that the architecture provides a very efficient method to design and implement the
flexible, distributed, open and intelligent electronic commerce platform system to solve problem of dynamic integration
in ecommerce. The objective of this paper is to illustrate the architecture of electronic commerce platform system, and
the approach how Agent and Ontology support the electronic commerce platform system.
Discovering complexity: decomposition and localization as strategies in scientific research

In Discovering Complexity, William Bechtel and Robert Richardson examine two heuristics that guided the development of mechanistic models in the life sciences: decomposition and localization. Drawing on historical cases from disciplines including cell biology, cognitive neuroscience, and genetics, they identify a number of choice points that life scientists confront in developing mechanistic explanations and show how different choices result in divergent explanatory models. Describing decomposition as the attempt to differentiate functional and structural components of a system and localization as the assignment of responsibility for specific functions to specific structures, Bechtel and Richardson examine the usefulness of these heuristics as well as their fallibility -- the sometimes false assumption underlying them that nature is significantly decomposable and hierarchically organized. When Discovering Complexity was originally published in 1993, few philosophers of science perceived the centrality of seeking mechanisms to explain phenomena in biology, relying instead on the model of nomological explanation advanced by the logical positivists (a model Bechtel and Richardson found to be utterly inapplicable to the examples from the life sciences in their study). Since then, mechanism and mechanistic explanation have become widely discussed. In a substantive new introduction to this MIT Press edition of their book, Bechtel and Richardson examine both philosophical and scientific developments in research on mechanistic models since 1993.
Metabolic cell reprogramming for the recovery of lost insulin-producing cells

My group aims at fostering the regeneration of insulin-producing β-cells in the diabetic pancreas by promoting the reprogramming of other islet endocrine “non-β” cells. I will use mice and human islets to trigger the metabolic reprogramming of: i) peripheral organs, in order to reduce hyperglycemia, and ii) human islet non-β-cells, to induce their acquisition of insulin secretion.
I developed transgenics to elicit total (>99%) or graded (5-90%) β-cell loss. These mice revealed that non-β-cells, which produce other hormones, can naturally switch to insulin production upon β-cell loss, and lead to diabetes recovery. My group recently showed that human non-β-cells, from healthy or diabetic donors, also display plasticity and can engage in regulated insulin secretion. 
What metabolic adaptations occur in peripheral organs in response to insulin deficiency, but without complications? Can metabolic reprogramming of peripheral organs, based on these adaptations, suffice to control glycemia? Can metabolic reprogramming change the identity of a cell? 
Natural recovery of euglycemia after β-cell loss is documented in mice. To know the mechanisms driving relief, my lab will characterize islet cell dynamics and circulating molecules (metabolites, RNA, peptides) after various degrees of β-cell loss. We will perform a full analysis of blood and peripheral organs in recovered mice, and an array of genetic and pharmacological experiments modulating BAT mass and function to test its role in taming hyperglycemia.
We will explore and define the metabolic differences between human β- and non-β-cells. Using monotypic “pseudoislets” we will do RNAseq, proteomics and metabolomics after exposure to glucose. We will quantify oxygen consumption, extracellular acidification and ATP production in response to nutrients and metabolic toxins. From this, we will genetically (CRIPR-Cas9) and chemically reprogram the metabolism of human non-β-cells to boost the expression of β-like genes.
Dirac semimetals based terahertz components

This project aims to provide theoretical and experimental basis, to perform proof of concept experiments and to build prototypes of the thinnest ever alignment–free components of the THz photonics. Being based on 2D Dirac semimetals (graphene, silicene, germanene) and metamaterials paradigm, the fabricated lenses, filters and polarizers will be capable to outdoing the existing ones in terms of performance, footprint and tunability in lab-on-chip integrated solutions. The project relies on solid theoretical background that will enable calculation of the constituent parameters of 2D semimetals with account for defects, doping, stacking, strain and external fields using ab initio and tight binding approaches. The advances in nanoelectromagnetics will be employed to reveal physical phenomena underlying the response of both individual Dirac semimetal based metaatoms and their arrays in the THz spectral range. From the experimental side, the DiSeTCom will feed into the development of feasible and easy to use techniques for fabrication of metasurfaces based on graphene/silecene/germanene that will lead to prototype of tunable THz passive components with unprecedented performance. Robust design and sensitivity analysis will allow us to develop revolutionary THz devices thereby contributing to the European technology and creativity through joint R&D and R&I multisectorial and international cooperation activities supported by knowledge sharing. The consortium will implement research/innovations by means of functional secondments and organization of training courses, research and industrial workshops aimed at knowledge and technology transfer, wider professional networking, acquiring new skills and exploitation of project results by European THz industry. Implementation of the DiSeTCom will bring in considerable enhancement of the potential and future career prospects of the researchers involved via well balanced profiles and world-wide professional network of the consortium.
Effect of DEE Oxygenate on Diesel in Algal Biodiesel-Diesel Blends on the Combustion Phenomenon of DI Compression Ignition Engines

Biodiesel derived from Stoechospermum marginatum is analysed in a CI engine to understand its feasibility to be used as fuel. In this study, Soxhlet extraction method was applied to extract the bio oil from the brown sea weed (S. Marginatum) with n-hexane as solvent. Considering the low FFA content through titration, base single stage transesterification process with methanol and NaOH at molar ratio of 8:1 is used and it yielded 84.5% of bio diesel. The test fuel is prepared with processed algae bio diesel and Di-Ethyl Ether in different blend ratios namely D80AB20, D70AB20DEE10 and D60AB20DEE20. The variation in combustion aspects are evaluated with constant concentration of algal bio diesel at 20% with variation in diesel and oxygenate concentrations. Consequential variation is observed in the combustion behaviour of CI engine on fuelling with test fuels. Comparable in-cylinder pressure is observed in bio-diesel blends and oxygenated blends. D70AB20DEEE10 exhibits superior heat release rate and pressure rise at all loads. The peak in-cylinder pressure and variation in ignition delay are also analysed in this study.
APOYO PARA MANTENER EL NEGOCIO DE LA MEJOR COMIDA ALEKSANDRA DUBIS

Debido al brote de COVID-19, BEST FOOD Aleksandra Dubis, en abril de 2020, registró una repentina disminución en el volumen de negocios en un 98,78 % en comparación con abril de 2019. Los empleados de la compañía no fueron despedidos, recibieron estacionamiento. Debido a la disminución en el número de clientes, la falta de ingresos, las pérdidas relacionadas con la falta de clientes afectaron la posición de la empresa en el mercado. La repentina escasez de ingresos y los costes fijos de explotación dieron lugar a una falta de liquidez. Los fondos recaudados se utilizarán para el pago de salarios, bienes, alquiler, seguro de vivienda. Permitirán el empleo, una nueva puesta en marcha y el desarrollo de la norma empresarial que se logró antes de la pandemia de COVID-19. La empresa BEST FOOD Aleksandra Dubis tiene un lugar de negocios en una ciudad termal en Szczawno-Zdrój, una ciudad con alto tráfico turístico. Mantener el empleo en el establecimiento de restauración tendrá un impacto significativo en la reconstrucción y el mantenimiento del atractivo turístico de la región al mantener un servicio de restauración que es extremadamente necesario. El mantenimiento de los puestos de trabajo también ayudará a reducir el desempleo en el mercado regional y a apoyar a las familias de los empleados empleados en la empresa.
ICES S.R.L.

EL DIRECTOR DEL PROYECTO ES SIG.RA ANTONELLA MERCURY, ACTUAL REPRESENTANTE LEGAL DE LA EMPRESA. DENTRO DEL ALCANCE DEL PROYECTO SE UTILIZARÁ PERSONAL ALTAMENTE CALIFICADO, INCLUYENDO DR. D.C. ALBINO DICERTO, PHD EN ECONOMÍA Y ORGANIZACIÓN EMPRESARIAL EN LA UNIVERSIDAD DE ROMA TOR VERGATA. EL PROYECTO CONSTA DE DOS FASES: A) ADQUISICIÓN DE TECNOLOGÍAS ÚTILES PARA EL DESARROLLO DE NUEVAS ÁREAS DE NEGOCIO Y PARA LA MEJORA SIGNIFICATIVA DE LA EFICIENCIA DE LOS MÉTODOS DE TRABAJO ACTUALES, TANTO CUALITATIVA COMO CUANTITATIVAMENTE; B) DESARROLLO Y COMERCIALIZACIÓN DEL NUEVO SERVICIO CON LA DIFUSIÓN DEL CONOCIMIENTO, POR PARTE DE LA COMUNIDAD, DE LAS METODOLOGÍAS MÁS EFICIENTES Y «VERDES» UTILIZADAS POR LA EMPRESA. LAS TECNOLOGÍAS QUE SE ADQUIRIRÁN DURANTE EL PROYECTO SON: — BOMBA DE TRANSFERENCIA PARA EL VACIADO DE LOCALES Y ÁREAS, PARA INTERVENCIONES RELACIONADAS CON DESASTRES AMBIENTALES Y EMERGENCIAS (INUNDACIONES E INUNDACIONES POR LLUVIAS FUERTES Y REPENTINAS, SIEMPRE MÁS
Tissue-Engineering the tumour microenvironment to improve treatment of pancreatic cancer

My vision is to address a clinical problem with a novel and transformative approach. Using my unique expertise in cell biology, tissue engineering and translational research I will design technology platforms to test new treatments for human pancreatic cancer.

Pancreatic tumours are cancers of unmet medical need with 85% of patients dying within 9 months of diagnosis. To find better therapies, we need patient-specific models that mimic the biology of tumour tissues and target interactions between malignant and non-malignant cells. Biomimetic tissue engineering is a powerful approach to generate 3D cancer models, however, only a few scientists use these technologies. Most 3D cultures of human cells include reconstituted matrices that originate from murine tumours containing undefined amounts of extracellular matrix and growth factors. There is no tissue-engineered 3D model that allows control over patient-specific and biomechanical characteristics of the pancreatic tumour microenvironment.

I hypothesise that 3D approaches that replicate the native tissue composition and biomechanical properties will behave like real tumours to provide clinically predictive platforms and to test novel treatments that target both malignant and non-malignant cells.

To test my hypothesis, I will:
•3D-print matrix and cellular elements of the microenvironment of human pancreatic tumours
•Develop a cancer-on-a-chip model of liver metastasis
•Compare the crosstalk of malignant and other microenvironment components with the human disease
•Validate my new platforms with treatments in clinical trials and test novel combination treatments that slow down or reduce tumour growth.

In a multidisciplinary project, I will use:
•3D printing to build platforms composed of hydrogels, fibrous scaffolds and patient-derived cells
•Extracellular matrix molecules for chemical crosslinking into hydrogels
•Cancer-on-a-chip models to study tumour metastasis
•Imaging, biomechanical and multi-omics analyses.
NAVIS: Neuromorphic Auditory VISualizer Tool

Abstract This software presents diverse utilities to develop the first post-processing layer using the neuromorphic auditory sensor's (NAS) information. The NAS used implements a cascade filters architecture in FPGA, imitating the behavior of the basilar membrane and inner hair cells, working with the sound information decomposed into its frequency components as spike streams. The neuromorphic hardware interface Address-Event-Representation (AER) is used to propagate auditory information out of the NAS, emulating the auditory vestibular nerve. Using the packetized information (aedat files) generated with jAER software plus an AER to USB computer interface, NAVIS implements a set of graphs that allows to represent the auditory information as cochleograms, histograms, sonograms, etc. It can also split the auditory information into different sets depending on the activity level of the spike streams. The main contribution of this software tool is its capability to apply complex audio post-processing treatments and representations, which is a novelty for spike-based systems in the neuromorphic community. This software will help neuromorphic engineers to build sets for the training of spiking neural networks (SNN).
Targeting crispr-based hdac inhibitors to histones: a new tool for assessing mechanisms of class i hdac inhibitors and developing chemical probes.

Cancer is responsible for 8.5 million deaths worldwide each year, representing a considerable burden for society. In cancer cells, tumor repression genes are deactivated by epigenetic mechanisms. The accessibility of DNA to transcription factors is determined in part by the chemical modifications of histones, proteins that pack DNA into condensed chromatin. When histones are deacetylated by histone deacetylases (HDACs), the chromatin structure is even more packed, preventing gene expression. HDAC inhibitors are epigenetic drugs currently in the market, able to increase histone acetylation, unpacking DNA for gene transcription. However, the specific mechanisms leading to the success or failure of those drugs are poorly understood, leading to unpredictable therapeutic outcomes. HDAC inhibitors are expected to interact with HDACs in the cell nucleus. However, fluorescence-labeling has revealed HDAC inhibitors to locate mostly outside the nucleus in living cells, suggesting that their genomic effects represent only part of their activities. This project aims at developing a set of tools, using a modified genome-editing method and a fluorescent chemical probe combined with genome-wide assays to understand specifically the genomic mechanisms of HDAC inhibitors. We will develop the CRISTONE (CRISPR-based HDAC inhibitor targeted to histones) tool to allow targeted HDAC inhibition. We will target an HDAC1 inhibitor (a histone tail peptide) specifically to repressed loci in the genome of HDAC1-overexpressing HEK 293T cells. To understanding the transcriptional consequences of targeted and untargeted HDAC1 inhibition, the CRISTONE effects will be compared to those of a new fluorescent chemical probe capable of inhibiting nuclear HDACs. To assess the cellular phenotypic outcome, we will test the genome-wide cellular effects on transcription and chromatin accessibility, giving insights into the specific effects of genomic, targeted HDAC inhibition.
Injecting Risk Behavior among Traveling Young Injection Drug Users: Travel Partner and City Characteristics

Young injection drug users (IDUs), a highly mobile population, engage in high levels of injecting risk behavior, yet little is understood about how such risk behavior may vary by the characteristics of the cities to which they travel, including the existence of a syringe exchange program (SEP), as well as travel partner characteristics. In 2004-2005, we conducted a 6-month prospective study to investigate the risk behavior of 89 young IDUs as they traveled, with detailed information gathered about 350 city visits. In multivariable analyses, travel to larger urban cities with a population of 500,000-1,000,000 was significantly associated with injecting drugs (adjusted odds ratio (AOR) = 3.71; 95 % confidence interval (CI), 1.56-8.82), ancillary equipment sharing (AES; AOR = 7.05; 95 % CI, 2.25-22.06) and receptive needle sharing (RNS; AOR = 5.73; 95 % CI, 1.11-27.95), as compared with visits to smaller cities with populations below 50,000. Region of the country, and the existence of a SEP within the city visited, were not independently associated with injecting drugs, AES, or RNS during city visits. Traveling with more than one injecting partner was associated with injecting drugs during city visits (AOR = 2.77; 95 % CI, 1.46-5.27), when compared with traveling alone. Additionally, both non-daily and daily/almost daily alcohol use during city visits were associated with AES (AOR = 3.37; 95 % CI, 1.42-7.68; AOR = 3.03; 95 % CI, 1.32-6.97, respectively) as compared with no alcohol consumption. Traveling young IDUs are more likely to inject when traveling with other IDUs and to engage in higher risk injection behavior when they are in large cities. Risk behavior occurring in city visits, including equipment sharing and alcohol consumption, suggests further need for focused interventions to reduce risk for viral infection among this population.
Empirical move-on rules to inform fishing strategies: a New England case study

Increasingly, fisheries are being managed under catch quotas that are often further allocated to specific permit holders or sectors. At the same time, serious consideration is being given to the effects of discards on the health of target and non-target species. Some quota systems have incorporated discard reduction as an objective by counting discards (including unmarketable fish) against the overall quota. The potential effect of the introduction of a quota system that includes accountability for discards on the fishing strategies employed by fishermen is enormous. This is particularly true for multispecies fisheries where healthy and depleted stocks co-exist; resulting in a trip’s catch being applied to very large and very small stock quotas simultaneously. Under such a scenario, fishermen have a strong incentive to minimize (i) catch of low-quota or ‘choke’ stocks, (ii) regulatory discards due to minimum size limits and (iii) catch partially consumed by predators. ‘Move-on’ rules (i.e. event-triggered, targeted, temporary closure of part of a fishery when a catch or bycatch threshold is reached) have been employed in a variety of fisheries. However, their efficacy has been limited by a lack of empirical analyses underpinning the rules. Here, we examine the utility of spatiotemporal autocorrelation analyses to inform ‘move-on’ rules to assist a sector of the New England Multispecies Fishery to reduce discards and maximize profits. We find the use of empirical move-on rules could reduce catch of juvenile and choke stocks between 27 and 33%, and depredation events between 41 and 54%.
SALT OF A PYRIDYL ETHANOLAMINE DERIVATIVE AND ITS USE AS A BETA-3-ADRENERGIC RECEPTOR AGONIST

The present invention provides the tosylate salt of (R)-2-(2-(4-oxazol-4-yl-phenoxy)-ethylamino)-1-pyridin-3-yl-ethanol, the monohydrate of such salt, processes useful in the preparation of such salt and such monohydrate, pharmaceutical compositions comprising such salt, or such monohydrate, methods of treating ß3-adrenergic receptor-mediated diseases, conditions, and disorders in a mammal using such salt, such monohydrate, or such pharmaceutical compositions; and methods of increasing the content of lean meat in edible animals using such salt, such monohydrate, or such pharmaceutical compositions.