SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Design of biomaterials with enzymatic logic gates

The present proposal takes a novel approach to design biomaterials with enzymatic logic gates. By mimicking enzymatic biocatalytic cascades present in natural tissues, these biomaterials will be able to receive and process multiple biochemical signals, and logically elicit therapeutic outputs in response to specific combinations of input signals. This goal will be realized using enzymatically active hydrogel particles (Specific Objective (SO) 1) as building blocks that will be assembled into biomaterial coatings (SO 2) or three-dimensional constructs (SO 3), which can be applied to surfaces of currently available biomaterials or serve as autonomous implantable biomaterials, respectively. To illustrate the wide applicability of this biomaterial design strategy, two major clinical challenges are selected as target applications, i.e., tissue regeneration and bacterial infection. 
The fellowship will harness the existing experience of the researcher in (bio)materials science, and will add a new dimension to this expertise in terms of biochemical signaling and enzymatic reactions. To achieve this goal, the researcher will carry out the outgoing phase of this fellowship at Harvard University, and then return to Eindhoven University of Technology for the incoming phase. The envisioned activities described in the proposal will prepare the researcher to emerge from this fellowship with additional scientific competences and transferable skills, and to establish an expanded international network. The success in this project will introduce a new class of biomaterials with dynamic signaling capabilities to elicit logic-based therapeutic effects, which can impact virtually all fields in which biomaterials are used, contributing to the enhancement of EU healthcare and economic interests. Through BioMaGic, the researcher will initiate an independent line of research as the basis for establishing an academic faculty career at a European research university.
Temporal variations in<sup>87</sup>Sr/<sup>86</sup>Sr and ɛ<sub>Nd</sub>in sediments of the southeastern Arabian Sea: Impact of monsoon and surface water circulation

Sr and Nd isotopic composition of silicate fractions of sediments have been measured in two well dated gravity cores from the eastern Arabian Sea archiving a depositional history of ∼29 and ∼40 ka. The 87 Sr/ 86 Sr and e Nd in the northern core (SS-3104G; 12.8°N, 71.7°E) ranges from 0.71416 to 0.71840 and −8.8 to −12.8; these variations are limited compared to those in the southeastern core (SS-3101G; 6.0°N, 74.0°E), in which they vary from 0.71412 to 0.72069 and −9.0 to −15.2 respectively. This suggests that the variation in the relative proportions of sediments supplied from different sources to the core SS-3104G are limited compared to core SS-3101G. The 87 Sr/ 86 Sr and e Nd profiles of SS-3101G exhibit two major excursions, ca. 9 ka and 20 ka, coinciding with periods of Holocene Intensified Monsoon Phase (IMP) and the Last Glacial Maximum (LGM) respectively with more radiogenic 87 Sr/ 86 Sr and lower e Nd during these periods. These excursions have been explained in terms of changes in the erosion patterns in the source regions and surface circulation of the Northern Indian Ocean resulting from monsoon intensity variations. The intensification of North-East (NE) monsoon and associated strengthening of the East Indian Coastal Current in southwest direction during LGM transported sediments with higher 87 Sr/ 86 Sr and lower e Nd from the western Bay of Bengal to the Arabian Sea. In contrast, enhanced South-West (SW) monsoon at ∼9 ka facilitated the transport of sediments from the northern Arabian Sea, particularly Indus derived, to the southeastern Arabian Sea. This study thus highlights the impact of monsoon variability on erosion patterns and ocean surface currents on the dispersal of sediments in determining the Sr and Nd isotopic composition of sediments deposited in the eastern Arabian Sea during the last ∼40 ka.
CATALYTIC REMOVAL OF NITROGEN OXIDES FROM EXHAUST GASES

AUTO EXHAUST CATALYST A catalyst that combines high activity and good stability for the conversion of nitrogen oxides to nitrogen in auto exhaust environments is described. The catalyst consists of a base metal component preferably nickel oxide combined with noble metals such as palladium, platinum, and rhodium, supported on a suitable base.
Multithreaded Two-Phase I/O: Improving Collective MPI-IO Performance on a Lustre File System

ROMIO, a representative MPI-IO implementation, has been widely used in recent large-scale parallel computations. The two-phase I/O optimization scheme of ROMIO improves I/O performance for non-contiguous access patterns, however, this scheme still has room to improve performance to make it suitable for recent data-intensive computing. We propose overlapping data exchange operations with file I/O operations by using a multithreaded scheme to achieve further I/O throughput improvement. We show up to 60% improvement by the multithreaded two-phase I/O relative to the original two-phase I/O in performance evaluation of collective write operations on a Lustre file system of a Linux PC cluster.
European training network to develop improved bioresorbable materials for orthopaedic and vascular implant applications

BioImplant ITN is a European Industrial Doctorate (EID) programme that will provide world-class multidisciplinary training to a new generation of high-achieving ESRs in the area of medical device development. A well-balanced consortium of academic, industry and clinical partners has been assembled to deliver the training programme, spanning a number of EU countries and industry sectors to promote international, interdisciplinary and inter-sectoral aspects of ESR skill development. The programme vision of the BioImplant ITN is to deliver technical, interdisciplinary and transferrable skills training to the ESR community all areas of the medical device development Supply Value Chain. The BioImplant ITN programme will develop improved bioresorbable materials and implement them in orthopaedic and vascular implant applications. Bioresorbable materials are rapidly gaining traction in soft and hard tissue medical implants, with both polymer- and metal-based resorbable materials having been developed for medical device applications. However, major issues relating to their poor mechanical properties and rapid degradation behaviour have limited their application. The research programme of the BioImplant ITN will address these issues by (i) targeting new processing solutions to enhance the mechanical behaviour of bioresorbable polymers and (ii) integrate high stiffness magnesium- and ceramic-based reinforcements with polymers to produce novel hybrid/composite materials with optimised functional performance. The development of these innovative biomaterials will represent a major advancement on the current state-of-the-art in bioresorbable materials and maximise commercial potential in vascular and orthopaedic applications. Furthermore, the comprehensive skillset delivered by the programme will enhance career development and employability of ESRs within the Medical Technology sector and promote their development into leading innovators in the European Medical Technology sector.
Bridge circuits

Bridge circuits are among the most elemental and powerful electrical tools. They are found in measurement, switching, oscillator, and transducer circuits. Additionally, bridge techniques are broadband, serving from DC to bandwidths well into the GHz range. Being the electrical analog of the mechanical beam balance, they are also the progenitor of all electrical differential techniques. An almost uncountable number of tricks and techniques have been applied to enhance linearity, sensitivity, and stability of the basic configuration. In particular, transducer manufacturers are quite adept at adapting the bridge to their needs. Careful matching of the transducer's mechanical characteristics to the bridge's electrical response can provide a trimmed, calibrated output. Similarly, circuit designers have altered performance by adding active elements to the bridge, excitation source, or both. A primary concern is the accurate determination of the differential output voltage. Bridge amplifiers are designed to accurately extract the bridge's differential output from its common mode level. The common mode suppression circuits shown require a negative power supply. Often, such circuits must function in systems where only a positive rail is available. The bridge's inherent nonlinear output is also accommodated by the processor. Level transducers which measure angle from ideal level are employed in road construction, machine tools, inertial navigation systems, and other applications requiring a gravity reference.
Mass spectrometry for single particle imaging of dipole oriented protein complexes

The European XFEL has just entered user operation. With its unparalleled peak brilliance and repetition rate, European XFEL has the potential to further applications in single particle imaging (SPI), thus far limited to large viral particles at X-ray Free-Electron Lasers (XFEL). SPI will allow imaging protein complexes without the need for crystallization. This eventually renders transient conformational states accessible for high resolution structural studies yielding molecular movies of biomolecular machines. A major bottleneck is the wealth of data required to reconstruct a single structure leading to long processing times. This is currently also a problem in electron microscopy (EM).
MS SPIDOC will overcome this data challenge by developing a native mass spectrometry (MS) system for sample delivery, named X-MS-I. It will provide mass and conformation selected biomolecules, which are oriented along their dipole axis upon imaging. This will enable structural reconstruction from much smaller datasets speeding up the analysis time tremendously. Moreover, the system features low sample consumption and a controlled low background easing pattern identification.
The main objectives of the project are:
• Deliver mass and conformation separated biomolecules for SPI.
• Orient proteins for SPI.
• Image protein complex unfolding
• Exploit potential of protein orientation for other applications
The MS SPIDOC consortium combines internationally leading expertise in different fields relevant to the project: Instrument design and development, computer simulations as well as working with biomolecules in the gas phase and on SPI are combined to implement the novel sample environment at the next generation XFEL facility. New components and methods will be opened to the market and thereby strengthen the European Research Area (ERA) and industry. This early stage high-risk project will give rise to a new technology with major impact on how to derive structures of biomolecules.
Improvements in or relating to chairs and like seats

889,300. Seat frames; upholstery. FURNITURE INDUSTRIES Ltd., ERCOLANI, L. B., and PEDEL, D. R. Nov. 4, 1959 [Nov. 7, 1958], No. 35840/58. Classes 52(2) and 52(4) A chair has a frame with parallel members 11, 12 supported on legs 14, 15 braced apart by members 16, 17, elastic members 13 being strung between the members 11 12. Specifications 800,828 and 881,621 are referred to.
METHOD AND SYSTEM FOR PROTECTING DATA

Method for authenticating and protecting data, comprising the providing of a plurality of challenging mines dispersed within an executable program file, each mine being dependent on one validation key located in at least one other mine, and optionally on additional keys, for allowing proper use of the executable program file and content files that can be activated by said executable program file.
Pushing the boundaries of cost and outcome analysis of medical technologies

The overarching objective of the COMED project is to push the boundaries of existing methods for cost and outcome analysis of healthcare technologies, both within the Health Technology Assessment (HTA) and Health System Performance (HSP) frameworks and to develop tools to foster the use of economic evaluation in policy making. Within this general agenda, the COMED project focuses on one broad category of healthcare technologies (medical devices) for exemplary, empirical purposes to: (i) improve economic evaluation methods for medical devices in the context of the HTA framework by increasing their methodological quality and integrating data from different data sources; (ii) investigate health system performance through analysis of variation in costs and outcomes across different geographical areas and (iii)strengthen the use of economic evaluation of medical devices in policy making. COMED’s ambition is to develop scientifically rigorous recommendations on what, when and how real world evidence sources can and should be used for assessment of medical devices.  COMED’s aim is to develop new methods for assessing patient reported outcomes for mHealth technologies. COMED will provide a comprehensive answer on the main drivers of clinical practice variations across Europe by differentiating between warranted and unwarranted causes of disparities. COMED will develop, for the first time, adequately researched policy advice for the early assessment and conditional reimbursement policy tools in the field of medical devices. The project will expand the geographic scope of evidence generation from a single jurisdiction to collaborative evidence generation throughout Europe. It will have a substantial impact by on public health in Europe, by providing scientifically robust evidence for a wide range of key stakeholders ranging from policy makers to patients and wider public
Ferroelectric polarization control of spin states in Mn4N/PMN-PT heterostructures revealed by topological Hall effect

Topological Hall effect (THE) as one of spin-related effects originates from scalar spin chirality formed by non-coplanar spin structures, being a promising tool for probing the change of electron spin. Single-phase (022) Mn4N films with coplanar spin structures were prepared on unpoled ferroelectric [Pb(Mg1/3Nb2/3)O3]0.67-[PbTiO3]0.33 (PMN-PT) substrates. The transport properties of Mn4N/PMN-PT have been investigated. The decreased magnetization and anomalous resistivity imply that the spin states of Mn4N are influenced by ferroelectric polarization of the substrate. The observation of THE in the Mn4N/PMN-PT heterostructure strongly supports that the spin states of Mn4N are modified. After poling PMN-PT, the enhanced THE peak magnitude verifies that the spin states of Mn4N are tuned by ferroelectric polarization. This study provides a non-magnetic method for manipulation of spin states, which could avoid the external magnetic field perturbations.
The effect of sample temperature on the emission line intensification mechanisms in orthogonal double-pulse Laser Induced Breakdown Spectroscopy

Abstract Orthogonal double-pulse laser ablation on aluminum-based alloy target at atmospheric pressure was investigated by time-resolved optical emission spectroscopy. Studies were performed as a function of the distance from the first pulse plasma induced in air to the sample surface. Double-pulse experimental results were compared to single-pulse laser ablation experiments carried out in a heated target to up to 500 °C. Emission line intensification mechanisms are discussed in terms of the sample heating by the pre-ablation pulse. Crater volume was also determined via confocal microscopy for both, double pulse and target heating, experiments. It was found that the emission intensification is mainly due to an enhancement of the ablated mass. The mechanisms for the mass removal increasing are discussed.
tema del martirio de Isaías en la sillería de coro de la catedral de Plasencia (Cáceres)

El desmontaje de los sitiales altos de la catedral de Plasencia con motivo de la restauración realizada recientemente por el Instituto del Patrimonio Cultural de España, ha permitido rescatar algunos fragmentos caídos que permanecían en una zona inaccesible. Con la recuperación de estos elementos se ha podido realizar su reintegración y reubicar el tablero con la representación del martirio de Isaías que estaba fuera de lugar y completar con ello el programa iconográfico del conjunto catedralicio.
Experimental analysis of dehumidification performance of an evaporative cooling-assisted internally cooled liquid desiccant dehumidifier

Abstract The aim of this study is to empirically investigate the impact of the working-to-primary air flow ratio variation on the dehumidification performance of an evaporative cooling-assisted internally cooled liquid desiccant dehumidifier. In the experiment, the process air passed through the primary (or dehumidification) channels of the internally cooled liquid desiccant dehumidifier at a constant flow rate, while the working air flow passing through the secondary (or evaporative cooling) channels was modulated to vary the working-to-primary air flow ratio from 0.25 to 1.0 in 0.25 increments. To evaluate the impact of the working-to-primary air flow ratio on the dehumidification and cooling performance of the internally cooled liquid desiccant dehumidifier, four different performance indices, i.e., cooling capacity, wet-bulb effectiveness, volumetric mass transfer coefficient, and coefficient of performance, were measured in a series of experiments performed under various working-to-primary air flow ratios. From those performance indicators, the overall heat, mass transfer performance, and energy efficiency of the internally cooled liquid desiccant dehumidifier could be rated. The experimental results indicate that the maximum values of the four selected performance indices are obtained at a working-to-primary air flow ratio of 0.5. To verify the reliability of the experimental results, a detailed simulation of the internally cooled liquid desiccant dehumidifier was performed using a sorption system simulation program (SorpSim). The measured performance data was in good agreement with the simulation results, within 20% error bounds. Consequently, we determined that the optimal dehumidification and cooling performance of the internally cooled liquid desiccant dehumidifier could be expected when the working-to-primary air flow ratio is 0.5.
Involuntary Public Policy-making by For-Profit Professionals: European Lawyers on Anti-Money Laundering and Terrorism Financing

EU directives on AML (anti-money laundering)/CTF (counter-terrorism financing) entail involuntary public policy-making by for-profit professionals on politically sensitive issues. This raises fundamental questions on the role of private actors in public policy-making apart from their roles as lobbyists and contractors. From a democratic perspective, the involuntary public policy-making by European lawyers is particularly problematic as it involves guardians of the rule of law who, we argue, are simultaneously forced to act as agents of the state. In the case of AML/CTF, lawyers are within the political system rather than outside it. We show that expectations concerning how lawyers are to work closely with the state in the United Kingdom and Sweden differ, and that the policy-making styles lawyers apply in practice were either ‘pragmatic’ (UK) or ‘evasive’ (Sweden). Our findings provide a first step in understanding the new role of for-profit professionals as involuntary public policy-makers, and its possible effects.
Climate Changes, Natural Resources Depletion, COVID-19 Pandemic, and Russian-Ukrainian War: What Is the Impact on Habits Change and Mental Health?

Climate Change, Natural Resources Depletion, COVID-19, and Wars are some of the great challenges of our time. The consequences will affect psychological well-being and could have a harmful impact on mental health. This study aimed to assess the level of preoccupation and fears surrounding issues of the 21st-century and the implication for psychological well-being of the general population from Central/Southern Italy among different age groups. A questionnaire that included sociodemographic characteristics, topics formulated ad-hoc about preoccupation, fears, habits, and willingness to change habits in the future related to the 21st-century challenges, and the Depression Anxiety Stress Scales 21 (DASS-21) was administered online. A sample of 1831 participants (61% F; mean age 47.71 ± 17.30) was obtained. Results showed that young adults and older adults, respectively, reported greater and less psychological well-being. Young adults reported higher scores for preoccupation, changing habits, and willingness to change habits in the future, while older adults reported the lowest scores except for changing habits, also controlling for gender. Results for this variable, as well as correlations between the many variables described, rely on the specificity of age, and 21st-century challenges. Moreover, the main fears related to the 21st-century concerns were different based on both age and gender. In conclusion, the various stresses of the 21st-century discussed in this study have a relationship with personal well-being, and it is important to consider potential global mental health issues resulting from these stressors.
The Double Bind: The Next Generation

In this foreword, Shirley Malcom and Lindsey Malcom speak to the history and current status of women of color in science, technology, engineering, and mathematics(STEM) fields. As the author of the seminal report The Double Bind: The Price of Being a Minority Woman in Science, Shirley Malcom is uniquely poised to give us an insightful perspective on the development of this field over the last thirty-five years. She has spent the intervening years working on increasing diversity and inclusion in STEM education and careers. Her daughter, Lindsey Malcom, represents the next generation of scholars seeking to understand and advance the representation of women of color in STEM. Together, they connect the past and the present regarding the pathways used by minority women entering STEM, their patterns of advancement,and shifting paradigms on how best to support women of color in these fields.
Multidimensional data object searching using bit vector indices

Prior to searching a multidimensional feature space populated with data objects, each dimension in the feature space is divided into a number of intervals. When a query is received, a single interval that is overlapped by the query is selected from each dimension. A reduced set of data objects is then selected that includes only those data objects that overlap the selected intervals. This reduced set of data objects, rather than the entire set of data objects in the feature space, is then used to determine matches for the query.