SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Linking sequence to function of long noncoding rnas with crispr.

A great surprise in the wake of the Human Genome Project has been the discovery of vast numbers of RNAs that do not encode proteins. Alongside 19,000 protein-coding genes, our genome contains at least 20,000 long noncoding RNA (lncRNA) genes, but recent estimates push that number to 100,000. Extensive annotation efforts are presently discovering lncRNAs far faster than their functions can be elucidated, and thus only <1% of lncRNAs have been experimentally characterised. These discoveries have created a grand challenge of understanding lncRNAs’ biological significance. To do this, we must solve the pressing question of how lncRNAs’ functions are encoded in their primary sequence. As a proxy of lncRNAs function we can use subcellular localisation since lncRNAs function as a mature RNA molecule. One hypothesis is that, similar to proteins, lncRNAs are modular molecules composed of separable functional domains. Previous studies, including my own, have used conventional methods to identify domains in a handful of lncRNAs by laborious deletion experiments. I propose to advance this field, via a novel high-throughput technique, CRISPR-Locate, capable of detecting lncRNA domains and their function in their natural endogenous context. I will delete ⁓1000 different lncRNA domains at the same time and simultaneously insert RNA tags at their place. Subsequently, I will fractionate cells by their compartments and purify tagged lncRNAs. Afterwards, I will sequence all the tagged lncRNAs and, by comparing the change in the subcellular localisation between mutated and wild type cells, I will identify which domains are responsible for subcellular localization. Finally, I will use CRISPR-Locate to create a map of lncRNA domains, an invaluable resource linking sequence to function, and bring us a step closer to unlocking the potential of 10^4 novel genes in medicine and biology.
DISPOSITIF DE JONCTION D'ELEMENTS TUBULAIRES PARALLELES D'UN SEPARATEUR A CYCLONES

<P>Dispositif de jonction de tubes de séparateurs à cyclones de mélanges liquide-vapeur. </P><P>Il comprend une plaque prédécoupée dans laquelle viennent se loger les extrémités hexagonales de formes embouties ou moulées de fonderie, se raccordant par leurs extrémités opposées aux sections droites des tubes, permettant d'offrir à l'entrée du mélange dans les tubes une section droite peu différente de celle du conduit d'amenée.</P>
CARDIAC LEAD WIRE PROTECTOR

A lead wire associated with a pacemaker, implantable cardiac defibrillator or other cardiac electric signal source is provided with a protector tube overlying at least a portion of the lead wire. In one embodiment, this protector tube is provided as a sheath tube portion of a sheath assembly along with a valve body. The valve body of the sheath assembly is fracturable and removable away from the sheath tube, leaving the sheath tube upon the lead wire as a protector tube. In other embodiments, a separate protector tube is provided and fed over the lead wire and through a sheath assembly until placed where desired. A grommet and/or plug can be provided at a proximal end of the protector tube for anchoring of the protector tube in a desired location and for plugging the protector tube, while also accommodating the lead wire passing therethrough.
KEY SWITCHING DEVICE

Bei einer Tastschaltvorrichtung ist eine Schaltkammer von einer flexiblen Schaltfolie überwölbt. Um eine klimabedingte Längenzunahme der Schaltfolie nicht zu einer Fehlschaltung führen zu lassen, weist diese bei der Schaltkammer wenigstens eine punkt- oder linienförmige Verformung auf. Die Verformung ist ein bleibender Knick der Schaltfolie, der zu deren Hochwölbung führt.
Green Impact MED Project - Positive Investments for Positive Impacts

The development of a green economy in the Mediterranean area to combat environmental degradation represents a great opportunity for jobs creation, particularly for young graduates and women who are three times less likely to be employed than men. Strengthening eco-innovative entrepreneurship is a recognised solution even though green ventures face a complex set of challenges including limited access to funding, underdeveloped markets and fragmented support from sector stakeholders. GIMED aims at boosting the development of eco-innovative ventures in order to create employment and drive the green and circular economy in the Mediterranean. The project will implement a United Nations-backed ‘Green Entrepreneurship Standard’ that will standardise the supportive inputs needed to generate successful ventures and will give those ventures a mark of quality to better access finance and markets. On the ground, the project will train and coach eco-innovators and encourage financiers to invest in the Mediterranean eco-innovation sector.
Balancing downlink and uplink soft-handover areas in UMTS networks

In this paper a static network simulator is used to find downlink and uplink SHO areas. By introducing a penalty-based objective function and some hard constraints, we formally define the problem of balancing SHO areas in UMTS networks. The state-of-the-art mathematical model used and the penalty scores of the objective function are set according to the configuration and layout of a real mobile network, deployed in Slovenia by Telekom Slovenije, d.d.. The balancing problem is then tackled by three optimization algorithms, each of them belonging to a different category of metaheuristics. We report and analyze the optimization results, as well as the performance of each of the optimization algorithms used.
Effects of precipitate aging time on the cerium-zirconium composite oxides

Abstract Cerium-zirconium composite oxides with high performance were synthesized by a co-precipitation method, using zirconium oxychloride and rare earth chloride as raw materials. The effects of precipitate aging time on the properties of cerium-zirconium composite oxides were investigated. The prepared cerium-zirconium composite oxides were characterized by X-ray diffraction (XRD), BET specific surface area, pulsed oxygen chemical adsorption, H 2 temperature-programmed-reduction (H 2 -TPR), scanning electron microscopy (SEM), etc. The results showed that the precipitate aging time caused great effects on the properties of cerium zirconium composite oxides. With the increase of aging time, the cerium zirconium composite oxides showed enhanced specific surface area, good thermal stability, and high oxygen storage capacity (OSC). The best performance sample was obtained while the precipitate aging time up to 48 h, with the specific surface area of 140.7 m 2 /g, and OSC of 657.24 μmolO 2 /g for the fresh sample. Even after thermal aged under 1000 °C for 4 h, the aged specific surface area was 41.6 m 2 /g, moreover with a good OSC of 569.9 μmolO 2 /g.
Surfactant influence in the performance of titanium dioxide photoelectrodes for dye-sensitized solar cells

Abstract The semiconductor thin film of dye-sensitized solar cells (DSCs) photoelectrodes is commonly fabricated from a paste containing TiO2 nanoparticles and whatever surfactant as a thickener or stabilizer. The aim of this paper is to study the influence of the type and quantity of the paste surfactant on the photoelectrode film features and cell performance. To this end, identical techniques and materials, except the film paste surfactant, will be used. Seven pastes are prepared with three surfactants in different quantities: Triton X-100® (T), polyethylene glycol 2000 (PEG) and ethyl cellulose (EC). The effects on the mesoporous film (film thickness and surface features like evenness, presence of cracks or aggregates, etc.) are studied because they are expected to play a major role in the performance of the DSC. The main finding is that the thickness of the TiO2 film strongly depends on the surfactant type and concentration. Fully operating DSCs have been manufactured using a natural dye as sensitizer and a liquid electrolyte, and their energy conversion efficiencies have been measured in environmental conditions. Higher efficiencies are obtained for thicker TiO2 films, thus showing the influence of the paste surfactant on the cell performance. Although the film surface characteristics are also influenced by the surfactant type and quantity, no clear correlation has been found between surface morphology and cell performance.
Perceptions of individuals living with spinal cord injury toward preference-based quality of life instruments: a qualitative exploration

Generic preference-based health-related quality of life instruments are widely used to measure health benefit within economic evaluation. The availability of multiple instruments raises questions about their relative merits and recent studies have highlighted the paucity of evidence regarding measurement properties in the context of spinal cord injury (SCI). This qualitative study explores the views of individuals living with SCI towards six established instruments with the objective of identifying 'preferred' outcome measures (from the perspective of the study participants).Individuals living with SCI were invited to participate in one of three focus groups. Eligible participants were identified from Vancouver General Hospital's Spine Program database; purposive sampling was used to ensure representation of different demographics and injury characteristics. Perceptions and opinions were solicited on the following questionnaires: 15D, Assessment of Quality of Life 8-dimension (AQoL-8D), EQ-5D-5L, Health Utilities Index (HUI), Quality of Well-Being Scale Self-Administered (QWB-SA), and the SF-36v2. Framework analysis was used to analyse the qualitative information gathered during discussion. Strengths and limitations of each questionnaire were thematically identified and managed using NVivo 9 software.Major emergent themes were (i) general perceptions, (ii) comprehensiveness, (iii) content, (iv) wording and (v) features. Two sub-themes pertinent to content were also identified; 'questions' and 'options'. All focus group participants (n = 15) perceived the AQoL-8D to be the most relevant instrument to administer within the SCI population. This measure was considered to be comprehensive, with relevant content (i.e. wheelchair inclusive) and applicable items. Participants had mixed perceptions about the other questionnaires, albeit to varying degrees.Despite a strong theoretical underpinning, the AQoL-8D (and other AQoL instruments) is infrequently used outside its country of origin (Australia). Empirical comparative analyses of the favoured instruments identified in this qualitative study are necessary within the context of spinal cord injury.
Prenatal stress increases adult vulnerability to cocaine reward without affecting pubertal anxiety or novelty response

Prenatal stress (PS) induces long-lasting molecular alterations in brain circuits of the offspring and increases the propensity to develop neuropsychiatric diseases during adulthood, including mood disorders and drug addiction. A major goal of this study was to assess the impact of PS on pubertal behaviour and adult vulnerability to cocaine-induced conditioning place preference (CPP). We therefore evaluated pubertal novelty response and anxiety-like behaviour in control (C) and PS rats, and then, we examined cocaine-induced CPP in those animals during adulthood. We found no differences between C and PS groups on pubertal behaviour, however, only PS rats showed a significant cocaine-induced CPP. To further analyze our results, we classified cocaine-treated rats regarding their CPP score in Low CPP or High CPP and we then analysed their pubertal behaviour. We found different relations of anxiety-like behaviour to cocaine reward as a function of PS exposure: for C group, High CPP and Low CPP had shown similar levels of anxiety-like behaviour at puberty; on the contrary, for PS group, High CPP had shown lower anxiety-like behaviour than Low CPP rats. This study underscores the importance of considering prenatal exposure to stress when analysing the relationship between anxiety and cocaine vulnerability. Moreover, the evaluation of behavioural traits at puberty opens the possibility of early intervention and will allow the development of specific prevention strategies to avoid the devastating consequences of drug addiction later in life.
TECHNOLOGY FOR MANUFACTURE OF MULTICOLOR KNITTED KNITTED KNITTED KNITTED KNITTED KNITTED KNITTED KNITTED KNITTED KNITTED KNITTED

The aim of the project is to implement Bowi-STYL’s innovative technology for producing 16 colour knitted knitted knitted knitted knitted knitted knitted knitted knits. The technology implemented as part of the project is based on an innovative approach to the production of knitted knitted knitted knitted knitted knitted knitted cylindrical knitting machines with electronic selection of needles on the cylinder and disc with a selection of four colors of yarns for each working area of the machine. It’s 38 inches. The new possibilities for creating a jacquard pattern with 16 colours are the result of installation in front of the guide, from the side of the contact frame, the device responsible for selecting, according to the design of the design, one of the four yarns, which will be served on a guide to supply the operating area of the knitting machine cylinder. The aim of the innovation will be to select yarns given to the “lock” that control the work of the crochet crochet elements, cut off the yarn previously served on the guide and tie to the cut end of the yarn selected from the other three in accordance with the design. In order to be able to function properly, the selection system must work with 4 magazine distributors responsible for the voltage stability of the yarn administered to the cylinder’s operating area. With 60 operating systems, the knitting machine will be equipped with 240 feeders. The above-mentioned technology will allow the production of innovative knitted knitted knitted knitted materials: Four times the number of colors knitted knitted knitted knitted knitted knitted knitted knitted knitted knitted fabrics with unlimited size of pattern report and quality in photographic resolution of exceptional softness and gentleness with the weight of knitted fabrics (max.350g/1 m²) with a low extensibility factor of knitted knitted fabric after ripping length (30-40 %) with the highest degree of resistance knitted knitted knitted fabric to abrasion abrasion? 5 % The technology of production of multicolor knitted knitted knitted knitted knitted knitted knitted knitted knitted knitted knitted textiles implemented within the project is the result of R & D works.
Multiphase capillary rise of multicomponent miscible liquids

Abstract The rise of the two-phase (gas and liquid) and two-component (water and ethanol) system in uniform capillaries was analysed by coupling earlier experimental data and a mathematical framework for multiphase capillary rise. These were used to determine how the meniscus position, velocity and acceleration were affected by the physical, chemical and thermodynamic parameters of miscible liquid components. These analyses demonstrated that these parameters could be determined from those of the pure substances, and allowed predicting the system state with residuals less than 1.6%. However, nonlinearities were not anticipated in the way thermodynamic parameters affected the meniscus velocity. Specifically, dynamic contact angle at the three-phase contact line was dominated by the meniscus velocity at low ethanol concentrations and by the thermodynamic parameters at high ethanol concentrations. The hypothesis by which regression equations are used to describe the dynamic contact angle is therefore rejected in favor of mechanistic equations, which may be used for an interpretation of the rise of liquids made of multiple miscible components.
Comparison between a spoke-type PMSM and a PMASynRM using ferrite magnets

Increasing concerns over costs and supply of rare earth magnets have introduced more attention to Permanent Magnet Synchronous Machine (PMSM) designs that can work with ferrite magnets. Ferrite magnets are weaker in comparison to rare earth magnets which makes it a challenge to achieve high torque density. In light of this, literature has introduced several PMSM designs that show an improved performance despite the challenges of ferrite magnets. This paper presents a comparison between the spoke-type PMSM design and the Permanent Magnet Assisted Synchronous Reluctance Machine (PMASynRM), both using ferrite magnets. The spoke type PMSM is based on an existing design, whereas the PMASynRM is designed by changing the configuration of the magnets in the rotor and using a lower number of poles. The PMASynRM design also incorporates some of the best practices from literature that are used to improve its performance. The objective is to determine which rotor configuration gives the best performance. In addition, a design used for quick implementation is presented. Finite Element Analysis (FEA) is used to analyze both designs, and some experimental results are shown.
An Optimized Design Technique of Low-bit Neural Network Training for Personalization on IoT Devices

Personalization by incremental learning has become essential for IoT devices to enhance the performance of the deep learning models trained with global datasets. To avoid massive transmission traffic in the network, exploiting on-device learning is necessary. We propose a software/hardware co-design technique that builds an energy-efficient low-bit trainable system: (1) software optimizations by local low-bit quantization and computation freezing to minimize the on-chip storage requirement and computational complexity, (2) hardware design of a bit-flexible multiply-and-accumulate (MAC) array sharing the same resources in inference and training. Our scheme saves 99.2% on on-chip buffer storage and achieves 12. 8x higher peak energy efficiency compared to previous trainable accelerators.
Cofund bist predoctoral programme

The PREBIST proposal is presented by the Barcelona Institute of Science and Technology (BIST) as beneficiary. PREBIST is an ambitious programme of 28 four-year fellowships for multidisciplinary pre-doctoral research at BIST´s constituent research centres and associated partner institutions (hospitals, private companies, technology centres, and other academic institutions), who will provide secondments, training, networking activities and other actions to complement the research activities and professional development of the fellows. 
The PREBIST proposal is a major initiative by which BIST aims to leverage the combined capacities of the constituent centres in a manner which none of them could do on their own and help achieve the strategic objectives of BIST. Key objectives of PREBIST are to:
• Boost the capacity for international talent attraction with increased visibility, strengthened recruitment processes, improved offerings of research areas with interdisciplinary and intersectorial aspects, and improved landing-pad processes to facilitate mobility;
• Improve BIST centre capacities in the management of researcher career development, scientific and technical training, and new offerings in complimentary skills training and outreach activities;
• Further drive interdisciplinary and intersectorial collaboration between BIST centres and other partner entities through joint research activities, secondments and technical trainings, improved access and utilisation of infrastructures, networking and development of personal contacts, joint seminars and workshops.
Near Infrared Spectroscopy and Food Authenticity

Near Infrared (NIR) spectroscopy has been developed as one of the most versatile methods to target authenticity, discrimination, or traceability issues in several food matrices. However, in order to adapt and apply this method to efficiently and consistently monitor authenticity issues in foods, we need to increase our understanding about the chemical and biochemical basis associated with origin/authenticity/traceability derived from the NIR spectra. One of the main advantages of NIR spectroscopy over traditional chemical and chromatographic methods (eg, High Performance Liquid Chromatography, Gas Chromatography, Gas Chromatography–Mass Spectrometry) are the speed, minimal sample preparation, and ease to use in an industrial setting or routine operations. This chapter will provide a general introduction to NIR spectroscopy and chemometrics. In addition, examples on the applications and uses of NIR spectroscopy targeting issues related with authenticity and traceability in several food products such as fish, meat, honey, and wine will be discussed.
POCKET SHUTTER

A shutter assembly includes a first and second shutter panel, where each panel includes a missile-repelling membrane panel, a frame having an elongated hollow body with inwardly disposed wall elements forming an inwardly facing U-shaped channel adapted to retain the membrane panel on at least two sides, and a membrane-retaining element separably attachable to the frame, allowing the membrane panel to be removed from the frame or secured within the frame.
Improving resource efficiency through a protective film for hose reel irrigation

Hose reel irrigation systems are a type of sprinkler irrigation that is portable and adapts to fields irregularly shaped or with obstacles. Farmers are increasingly demanding hose reel irrigators with long hoses (up to 1,000 m) but the high friction between the hose and the ground is troublesome and make it necessary to use heavy tractors and thick hoses. The energy for pumping water (and hence operation costs, fuel consumption and greenhouse gas emissions) directly depends on the thickness of the hose. Breakdowns and lifespan are also related to friction because it is the responsible for traction efforts on the hose and wear and tear.  Irriland has over 24 years of experience in automatic hose reel irrigators, being one of the world leaders in the sector. In 2013, and based on the client’s feedback, Irriland started developing PROTECTOR. This is a disruptive and robust technology which, neither adding difficulties nor delaying the process, reduces 90% of friction between the hose and the ground. The energy consumption is therefore reduced (around 22% for pumping water and 40% for deploying and removing the hose) as well as greenhouse gas emission (around 20%). Half the plastic is used in hoses, which turn more manageable and double their lifespan (20 years instead of 10). At the same time, all breakdowns caused by tractor efforts are avoided and irrigation is possible in more conditions (rainy times, muddy grounds, etc.). We have patented our technology in our main target markets and 22 irrigation systems sellers or farmer have explicitly shown their interest in the project. With PROTECTOR we forecast an accumulated sales revenue of € 10 million by 2024 with net profits of € 3.5 million by that same year. Our headcount will increase with 26 new direct jobs and we will consolidate our position in irrigation and will lead the way towards more efficient and sustainable hose reel irrigation.