SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Paternal epigenetic inheritance: a man’s life experiences may impact health of his unborn children and grandchildren

Epigenetic inheritance may not only occur in plants and fungi but also in mammals. While the effect of maternal lifestyle and in utero exposures is well studied, paternal epigenetic inheritance is a novel research field, especially in regard to chemical exposures. Many environmental pollutants exhibit anti-androgenic function. Despite the vital role of androgens in spermatogenesis, the effects of adult anti-androgen exposure on the sperm epigenome and offspring phenotype have been scarcely studied. 
   The overall aim of this novel project is to increase the understanding of if, and how, male life experiences such as adult exposure to the anti-androgenic model substance and pollutant DBP (di-n-butyl phthalate) may affect offspring through paternal epigenetic inheritance. I accomplish this by integrating animal and human studies, using RNA-sequencing and mass spectrometry-based peptidomics to identify DBP-induced alterations in the sperm transcriptome and peptidome, examine noncoding RNAs and peptides role in embryogenesis, development and long-term health of the offspring in two generations. To validate the mechanistic importance of the sperm molecular alterations microinjections of selected biomolecules into zygotes will be conducted. This is the first project to investigate multigenerational effects of adult male exposure to anti-androgens in detail, and investigate the role of the sperm peptidome in paternal epigenetic inheritance.  Directly linking animal experimental data about paternal transmission to human studies is unique and necessary to determine causal connection between environmentally-induced biomolecular alterations in sperm and offspring phenotype. The project can contribute to ground-breaking mechanistic understanding of how male life experiences may affect offspring through epigenetic inheritance. The findings may also have important public health implications via new regulations of anti-androgenic chemicals and male preconceptional interventions.
Successful novice's training in obtaining accurate assessment of carotid IMT using an automated ultrasound system

The aim of this study was to assess the feasibility and learning curve of training novice operators in using automated ultrasound to achieve satisfactory carotid intima-media thickness (CIMT) measurements.Four novices underwent 4 weeks carotid ultrasound training using a newly developed automated ultrasonograph. A longitudinal B-mode image of the distal right common carotid artery (CCA) was acquired in 96 patients. The interoperator CIMT reproducibility was analysed by the coefficient of variation (CV) and intraclass correlation coefficient (ICC) for every week and compared with that from an expert operator. The weekly mean CV of the measurements on the 24 patients made by all novices was consistently reduced: 0.06, 0.05, 0.03, and 0.02, respectively. For the expert, the mean CV was 0.02, 0.02, 0.03, and 0.02, respectively. The novices' standard deviation (SD) of CVs also reduced weekly from 0.04 in the first week to 0.01 in the last week (P < 0.05). The corresponding weekly variation in the SD for the expert was 0.02 for the first week to 0.01 in the last week (P = 0.27). The agreement between measurements made by the novices was expressed by the ICC being 0.97 (P < 0.001) in the first week and increased to 0.99 (P < 0.001) in the fourth week.CIMT assessment by novices using an automated ultrasound could be reliably achievable after a short training period. These results may have encouraging implications when designing screening programmes for primary prevention in community health service.
Rural rEvitalisation For cultuRal hEritage

REFREsh tackles the main challenges of rural areas in CE regions. Unused industrial heritages exist which need a revitalisation and a new form of use. One approach often Cities use is to involve creative scene in the reutilization of industrial heritages and areas. In rural areas this often fails through a missing critical amount of creative actors to sustainable reutilize the industrial sites alone. For that a multifunctional approach is necessary by combining the established stakeholders from trade, industry and services with the creative scene. Just by working together in close cooperation a mutual added value and sustainable reutilization of sites can be achieved. The main objectives of REFREsh are therefore to reutilize industrial heritages through new forms of creative use and attract new creative actors for valorise the industrial heritage in cooperation with actors from trade and service sector.
The partnership consists of Municipalities, regional and cultural actors from 5 countries in CE bundle there competences to provide benchmark tools for analysing territorial situation and combination options for creative, trade, and service actors, develop regional strategies for the integration of creative scene in the reutilization of industrial areas into cultural attractive places in cooperation with trade and service sectors. The projects transform industrial heritages into cultural centres for creative scene as starting point for development of the industrial areas, Municipalities and regions in Central Europe. To reach enough creative actors and foster transnational cooperation of creative scene transnational exhibitions, cultural events and creative workshops are implemented in the reutilization to attract creatives in taken part in reutilization and increase competence form politicians, planners, site managers how to integrate creative scene for the joint development of industrial areas as starting point for further reutilization in whole CE.
Long-Term structural performance of pre-stressed concrete bridges: a risk-based monitoring informed framework for life-cycle asset management

Recently, the re-assessment of the collapse of the Koror-Babeldaob Bridge (in 1996), a pre-stressed bridge built by the cantilever method, concluded that this was due to excessive deflections that appeared and grew non-linearly some years after construction. Interestingly, similar trends were found for a group of 56 similar bridge spans, raising the question whether such concerns could influence the maintenance and service life of a high number of pre-stressed bridges in Europe and beyond. Although individual material and structural factors have been researched, this problem can only be solved by integrating physical and probabilistic models and benefiting from the increasing use of monitoring data. This proposal aims to:
1.Review existing models for shrinkage and creep at specimen level,
2.Establish robust hybrid FE models for medium/long-term predictions,
3.Develop a novel monitoring approach based on Digital Image Correlation (DIC),
4.Formulate a time-dependent reliability assessment framework, addressing creep and shrinkage uncertainties,
5.Produce representative performance-time profiles for pre-stressed bridges based on the proposed framework and models.
The above will be demonstrated via a case study – the Lezíria Bridge – possessing a unique combination of factors: (i) available monitoring data, (ii) pre-existing analysis models and (iii) an intimate knowledge by Dr. Helder Sousa, the researcher, of its construction and behaviour. The findings will be directly relevant to the growing number of bridges with this problem, enhancing the European knowledge and competitiveness in the global infrastructure market. For this, an interdisciplinary research and training programme has been set out, building on the researcher’s strong track record, expanding/honing his knowledge/skills, so that he can reach the forefront of highly qualified professionals able to solve problems in a creative/integrative manner, contributing to European expertise and wealth creation.
Centralized heart rate monitoring telemetry system using ZigBee wireless sensor network

Recent advances in wireless communication standards and medical monitoring system have made it possible to effectively combine mesh networking with Non-Invasive medical application which is Pulse Oximeter in order to create reliable, large-scale wireless Network. This Mesh networking will enable doctors and nurses to observe and monitor a number of patients simultaneously from one location without being with the patient's physically. This project is mainly concerned about monitoring patient's condition simultaneously via Wireless Mesh Network. Wireless Mesh Network is a network that allows data transmitted to the node's nearest neighbors and it can be easily maintained as each node are self configuring and self healing. Data obtained from multiple pulse oximeters will be stored and processed using Arduino-Nano, then transmitted to a centralized unit, where the information for multiple oximeter will be displayed simultaneously. The efficiency of data transmission was monitored and verified. Mesh networking for pulse oximeter had been successfully design to show the active pulse oximeter. Besides, the data transmit and received by the XBee were accurate and it had been proved through several observations.
The Application of the Analytic Hierarchy Process (AHP) in Mine Geological Environment Evaluation

Mine environmental geological assessment usually uses the expert subjective assignment to determine the weights of affecting factors, but the mine environmental geological problems are the result of many factors. Each factor is complex on the suitability of the influence factors, and the factors interrelate and restrict each other, so the human factor is of great impact. Take the geological quality evaluation of the mine environment of Shanxi, Shaanxi and Inner Mongolia mining area as an example, this article discusses in detail the process of determining the weights of evaluation factors by using the analytic hierarchy process (AHP), which increases the scientific nature of the assignment and reduces the subjectivity, which achieves satisfactory results.
Value or waste: Perfusion imaging following radiofrequency ablation – early experience

Radiofrequency ablation (RFA) is an evolving technique in treatment of hepatic malignant tumors. By heating local tissue it leads to coagulative necrotic areas around the ablation probe. Temperature falls with increasing distance to the probe, risking incomplete necrosis at the margins of the RFA-induced lesion. Therefore, immediate non-invasive and precise detection of incomplete ablation is necessary for early enlargement of the ablation if needed.This in vivo pig study compares early experiences of immediate post-interventional computed tomography (CT) perfusion volume analysis to macroscopic and CT image evaluation in healthy pig liver.RFA was performed in vivo in healthy pig livers. Different CT perfusion algorithms (Maximum slope analysis and Patlak plot) were used to quantify three different perfusion parameters. Data points were acquired from rectangular grids. These grids were semiautomatically overlayed to macroscopic images documented after liver explantation. Each data point was visually assigned to zones defined as "inner" and "outer necrotic zone", "margin" or "vital tissue".Significant differences between necrotic zones and vital tissue are shown for equivalent blood volume (p < 0.0001), arterial flow (p < 0.01) and flow extraction product (p < 0.001). Looking at equivalent blood volume and flow extraction product, there were also significant differences (EquivBV: p < 0.0001, FE: p < 0.001) between margins, necrotic and vital areas.In a porcine model these early results could show that all of the used CT perfusion parameters allowed discrimination of necrosis from vital tissue after RFA at high levels of significance. In addition, the parameters EquivBV and FE that give an estimate of the tissue blood volume and the permeability, were able to precisely discern different zones also seen macroscopically. From this data CT perfusion analysis could be precise tool for measurement and visualization of ablated liver lesions and for immediate detection of incomplete ablation areas.
Bacteriophages, phage-host interactions and evolution of defence mechanisms in beneficial bacterium propionibacterium freudenreichii

Bacteriophages (phages) infecting Propionibacterium freudenreichii, a bacterium known for production of active vitamin B12 and for causing well-documented benefits to human health, are more diverse than those identified for closely related genera. At the same time, the defence mechanisms protecting the bacterial strains (hosts) from phage attacks are more diverse as well. These two phenomena suggest that P. freudenreichii strains and their phages have experienced complex interactions in phage-bacterium arms race. However, both phages attacking, and the defence mechanisms that this important food-grade Actinobacterium uses to protect itself from phage attacks are currently severely understudied. In CO-DEfENDENCE, I will use an innovative approach of systematic study of the defence mechanisms not only from the perspective of the bacterium, but also from the perspective of the phage. The use of strains and phages isolated from samples of different origin will ensure diversity of material subjected to analyses by a combination of phenotypic, genomic, proteomic and imaging methods. This multidisciplinary approach is possible due to guidance offered by world-class phage specialists at one of the world’s top universities, the University of Copenhagen. The expected result of CO-DEfENDENCE is elucidation of complex interactions between P. freudenreichii and its phages, which led to the high diversity of the phages and the multitude of defence mechanisms employed by the strains.  As an added benefit, these results have a great potential for being translated into novel genetic tools and to aid the development of phage therapies, especially those aimed at pathogenic Actinobacteria.
S09-5 Precarious employment in chile: macroeconomic determinants of the association with self-reported health

Introduction Employment and working conditions are key determinants of health and health inequities in middle and high-income countries like Chile. They are also key determinants of occupational health outcomes and occupational health inequities. Individual determinants of poor employment conditions and health have been abundantly studied, mainly related to the axes of inequalities and disadvantage in the labour market. Contextual determinants, however, including policies and regulatory frameworks, but especially macroeconomic conditions and economic structure, have seldom been analysed as determinants of health through the mediation of employment conditions. In Chile, questions pertaining to individuals and their eco-social context can be answered by comparing across the Chilean Regions given their differentiated economic structures and macro-economic outcomes. Methods This study addresses these questions through the three following specific stages: i) a multilevel study assessing the association between employment precariousness and self-reported health in Chilean workers by region estimating regional risk ratios (RRR), with individual-level data from the first Chilean Work, employment health and quality of life survey (2009-2010); ii) assessing to which extent such association is varying across Chilean regions using the I² statistic; iii) investigating which regional-level macro-economic factors are associated with the magnitude of the RRR, performing random effects meta-regression analyses. Results We found that there is a regional variation in the probability of reporting poor health across levels of employment precariousness (I² = 44%). We particularly found that GDP variability, especially during the 2008 economic crisis period, was associated with the magnitude of the RRR. Specifically, we found that the higher the economic crisis impact on regional GDP, the higher the impact of employment precariousness on workers’ self-reported health. Conclusion Results show that macro-economic factors can play a role in employment conditions’ impact on occupational health, highlighting the necessity of designing occupational prevention policies that integrate macroeconomic conditions and economic structures.
Automatic analyzer and the analyzing method using the same

An automatic analyzer which assures uniformity in mixing effects regardless of sample quantity and test item and thus produces analysis results with high repeatability. The analyzer includes a device for adding a conditioning liquid into a reaction chamber so that the quantity of liquid in the reaction chamber becomes a predetermined quantity at latest just before mixing. The conditioning liquidmaybe adiluent orphysiological saline as used for dilution of a sample or any other special liquid that adjusts the properties such as viscosity, surface tension, etc. of liquid to be mixed.
E-LATCH WITH MICROCONTROLLER ONBOARD LATCH AND INTEGRATED BACKUP ENERGY

A latching assembly is used on a door of a motor vehicle, wherein the motor vehicle includes a main electric supply and a striker. The latching assembly includes a ratchet that is selectively rotatable with respect to the striker to latch and unlatch the door. The latching assembly includes a pawl that is selectively engagable with the ratchet to selectively prevent the ratchet from rotating. The latching assembly includes a motor which is electrically connected to the main electric power supply. The motor is operatively connected to the pawl for pivoting the pawl into and out of engagement with the ratchet. The latching assembly also includes a backup battery disposed adjacent the motor for supplying electric power when the motor is disconnected from the main electric supply.
Circulating matrix metalloproteinases and their inhibitors in inguinal hernia and abdominal aortic aneurysm.

There is evidence supporting the role of matrix metalloproteinases (MMPs) and their inhibitors (TIMPs) in aortic and abdominal wall connective tissue degeneration, resulting in aneurysm and hernia formation. Furthermore, clinical association studies have demonstrated increased prevalence of abdominal wall hernias in patients with aortic aneurysms. Our objective was to estimate the levels of MMPs and TIMPs in the blood of patients with aortic aneurysm and inguinal hernia, in order to investigate whether there is potential pathogenic linkage of impaired collagen metabolism.Plasma concentrations of MMP-9, MMP-2, TIMP-1 and TIMP-2 were quantified using ELISA in 33 male patients with abdominal aortic aneurysm and 91 male patients with inguinal hernia. They were consecutive patients undergoing repair during the study period. The same substances were measured in 35 healthy male controls.MMP-9 and MMP-2 concentrations were lower in the plasma of patients with inguinal hernia and abdominal aortic aneurysm than controls, with hernia patients having the lowest circulating levels. The levels of TIMP-2 were significantly elevated in patients with inguinal hernia and significantly reduced in patients with aortic aneurysm, whereas opposite correlations were found for circulating TIMP-1.Different patterns of circulating MMP and TIMP levels were found in patients with aneurysm and hernia compared with controls. Underlying pathogenic processes implicating MMPs and TIMPs in connective tissue metabolism are expressed by differing plasma levels in the two disease states. Further research including combined plasma and tissue analyses is required to further investigate potential common pathogenesis of these diseases.
Natural ring structures on the Baikal ice cover: analysis of experimental data and mathematical modeling

Abstract Hydrophysical studies and mathematical modeling of ring structures during ice cover on Lake Baikal have shown that their existence at the stage of ice cover degradation is due to anticyclonic currents. Such currents can be generated as a result of local upwelling, which we associate with the rise of methane hydrates from the top layer of bottom sediments and their dissociation. Analysis of satellite images shows that the radii of ice rings range from 1300 to 2400 m, which is close to the baroclinic Rossby radius. The measured ice thicknesses in the area of the rings are in agreement with model calculations. Deep water renewal in Lake Baikal can also be associated with the rise of hydrates.
Trajectories of social, emotional and attention problems following very preterm birth: individual participant data meta-analyses via international data sharing

Each year over two million babies are born very preterm (VP; <32 weeks’ gestational age) and/or with very low birthweight (VLBW; <1500g) worldwide. Despite improved neonatal care, these children remain at high risk for developmental problems later in life. The most common adverse outcomes are social, emotional and attention problems which can impact on a child’s lifelong health and wellbeing. It is therefore critical to understand trajectories of social, emotional and attention problems after VP/VLBW birth to target intervention and improve outcomes across the lifespan. However, although a wealth of data has been collected, there is a paucity of research investigating trajectories of social, emotional and attention development in this population. This project will utilise data from 28 international birth cohort studies, comprising data from an unrivalled sample of 7,053 VP/VLBW participants, the investigators of which have already agreed to data sharing. Novel, innovative statistical techniques will be applied to harmonise different measures of social, emotional and attention problems producing a unique dataset that will allow me to use complex multilevel and longitudinal growth modelling to analyse trajectories from birth to adolescence. The results will advance theoretical understanding of the developmental pathways to social, emotional and attention problems and will have international impact informing the development of clinical guidelines for follow-up care, multidisciplinary intervention, parental counselling and educational policy and planning. The ultimate aim of my proposed research is to improve lifelong outcomes for the growing population of children born very preterm. The training and experience I will gain from working with leading multidisciplinary teams in this field of research will provide me with a unique opportunity to develop myself as an independent academic with the skills, collaborations and expertise needed to become a future research leader.
VACUUM LAMINATOR

An apparatus and a method for vacuum laminating an article to a substrate. The apparatus comprises a movable assembly (20) engaged with a support surface for the substrate and movable relative thereto. The movable assembly (20) comprises a manifold (24) for receiving vacuum force from a source of vacuum, and a fin member for translating the vacuum force across substantially a width of the printing plate (14). A holder for the article is positioned such that an end of said article to be laminated is engageable with the support surface. A moving device is provided for passing the movable assembly and the article over the printing plate as the vacuum force is translated across the printing plate, such that the article is laminated to the printing plate without substantial air entrapment.