SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Magnetic sphincter augmentation and fundoplication for GERD in clinical practice: one-year results of a multicenter, prospective observational study

The techniques available for antireflux surgery have expanded with the introduction of the magnetic sphincter augmentation device (MSAD) for gastroesophageal reflux disease (GERD).A prospective, multicenter registry evaluated MSAD and laparoscopic fundoplication (LF) in clinical practice (ClinicalTrials.gov identifier: NCT01624506). Data collection included baseline characteristics, reflux symptoms, proton-pump inhibitor (PPI) use, side effects, and complications. Post-surgical evaluations were collected at one year.At report, 249 patients (202 MSAD patients and 47 LF patients) had completed one-year follow-up. The LF group was older and had a greater frequency of large hiatal hernias and Barrett's esophagus than the MSAD group (P < 0.001). The median GERD-health related quality of life score improved from 20.0 to 3.0 after MSAD and 23.0 to 3.5 after LF. Moderate or severe regurgitation improved from 58.2 to 3.1% after MSAD and 60.0 to 13.0% after LF (P = 0.014). Discontinuation of PPIs was achieved by 81.8% of patients after MSAD and 63.0% after LF (P = 0.009). Excessive gas and abdominal bloating were reported by 10.0% of patients after MSAD and 31.9% following LF (P ≤ 0.001). Following MSAD, 91.3% of patients were able to vomit if needed, compared with 44.4% of those undergoing LF (P < 0.001). Reoperation rate was 4.0% following MSAD and 6.4% following LF.Antireflux surgery should be individualized to the characteristics of each patient, taking into consideration anatomy and propensity and tolerance of side effects. Both MSAD and LF showed significant improvements in reflux control, with similar safety and reoperation rates. In the treatment continuum of antireflux surgery, MSAD should be considered as a first-line surgical option in appropriately selected patients without Barrett's esophagus or a large hiatal hernia in order to avoid unnecessary dissection and preserve the patient's native gastric anatomy. MSAD is an important treatment option and will expand the surgeon's role in treating GERD.
Luminescent polymer nanoparticles with aza-bodipys, porphyrins and their metal complexes for fret mediated ratiometric oxygen sensing

This proposed Fellowship brings together an Experienced Researcher from India with expertise in the synthesis of photosensitizers and their photophysical characterization, tuning the excited-state properties, investigation of their photophysics and photobiology with an internationally recognized Host Laboratory in France with expertise in designing fluorescent molecular and nanoparticle probes for bioimaging. This project will provide (i) interdisciplinary training of highest quality to become an outstanding scientist with excellent publication record; (ii) enhance European excellence in organic synthesis, nanosciences and biophotonics. The aim of the research project is to obtain ratiometric probes for molecular oxygen based on biodegradable polymeric nanoparticles (NPs) bearing far-red/near-infrared absorbing triplet sensitizers such as aza-BODIPYs, porphyrins and corresponding metal complexes. The project involves the synthesis of phosphorescent dyes (aza-BODIPY/porphyrins) and formulation of polymeric NPs encapsulating these dyes. The development of ultra-bright polymer nanoparticles, an innovative method recently discovered in the Host Laboratory, will enable the development of novel dual emissive polymeric NPs with the triplet sensitizers. In our design, fluorescent NPs excite triplet sensitizers through energy transfer (FRET), resulting in dual emission: fluorescence of NPs and phosphoresce of the sensitizer. Only phosphorescence of FRET acceptor is sensitive to molecular oxygen (3O2), which provides the mechanism of dual colour ratiometric response to oxygen. The approach will be further validated in solutions and in living cells. The obtained nanoprobes for oxygen will be applied to living cell and (in collaboration) to whole animals. It is our strong conviction that the possibilities of this multidisciplinary chemistry are enormous, and the end result will be the development of a simple nano-device for molecular oxygen build from biodegradable materials.
Acute development of a paradoxical pulse in a child

Background Paradoxical pulse is defined as a decrease of systolic blood pressure for more than 10 mmHg during inspiration. In this presentation we would like to show the abrupt development of paradoxical pulse observable by direct intra-arterial blood pressure measurement. Acute development of a paradoxical pulse is important in recognizing tamponade development primarily due to acute bleeding. This can lead to acute cardiogenic shock and resuscitation. A four month old infant underwentsurgery for Tetralogy of Fallot. Postoperative course was uneventful. On the second postoperative day mediastinal and pleural tubes were removed together with atrial and ventricular electrodes. Several seconds after removal, a normal and regular intra-arterial pressure wave on the monitor became highly distorted and irregular with abnormal pulse wave and the presence of tachycardia and hypotension. Bedside transthoracic echocardiogram (TTE) showed a 10 mm wide pericardial effusion. Urgent resternotomy was done in the operating room andthe vast amount of coagulum with dark venous blood was found in the pericardium. Active bleeding of the right atrium auricula was verified at the site where a temporary unipolar electrostimulation electrode was previously positioned. The infant was extubated the same night and discharged from the hospital on the fourteenth day.
DAMPAK PERPINDAHAN PASAR TERHADAP KERUANGAN DISEKITARNYAKASUS PASAR MUNTOK KABUPATEN BANGKA BARAT

The need for market in a city is essential in meeting the needs of the
population. In 2006, the Government of West Bangka Regency built traditional
markets to relocate the old market. The objective of this study is to identify
impacts arising from new market shift towards surrounding area and to identify
factors that influence spatial effects, with Muntok traditional market as locus. The
research was conducted using qualitative and deductive methods and data
collection was conducted by secondary survey, observation, and interviews with
the research variabels of the study are physical and economy.
The research showed that the displacement site of Muntok markets have
impacts for instance: increasing the number, function, and density of building
inside and outside the market place, change in visitor mileage, decrease air
quality, development of economic activity around the market, flood prone
locations around the market and the increasing acceptance market levies. The
factors that influence the occurrence these impacts are the availability of new vast
market area, there is no bridge for vehicle that connects new markets with the old
market, deviations from the implementation RDTR Muntok City, and drainage
channels that markets do not function properly.
This study recommends that the Government of West Bangka Regency
should construct bridge that connects the old market with new markets, create
water disposal channels especially residential which is lower than the market
toward the river, and conduct reforestation and dredge in Muntok river, conduct
reforestation around the coastal beaches and residential areas, and improve
drainage in the market.
A MOTOR

A motor comprising two or more rotors (20, 30) rotated by means of a common power supply (6), each rotor (20, 30) having a plurality of poles (22, 32) and being associated with a stator (16, 26) having a plurality of poles (18, 28), wherein the arrangement of rotor poles (22, 32) and stator poles (18, 28) is different for each rotor (20, 30) so that the rotors (20, 30) rotate at different speeds when the common power supply (6) is applied.
Random matrices, random graphs and circular elements

Random matrix statistics are a paradigm for the collective behaviour of many strongly correlated random variables. The proposed projects will fundamentally advance our knowledge about random matrices in novel directions.   

We study spectral properties of random matrices when the matrix size becomes large. More specifically, we establish the universality of the fluctuations of the smallest singular value of almost square random matrices with independent entries. Moreover, we determine the asymptotic eigenvalue density of non-normal random matrices with correlated entries of general expectation and the Brown measure of operator-valued circular elements. We also obtain a central limit theorem for the difference of the linear statistics of a matrix with independent, identically distributed entries and its minor. Furthermore, we analyse the spectra of random graphs. Specifically, a transition in the eigenvalue fluctuations of very sparse Erdos-Renyi graphs, the eigenvector delocalisation of directed Erdos-Renyi graphs as well as the extreme eigenvalues and eigenvectors of preferential attachment graphs. Finally, we investigate a variational problem motivated by wireless communication.   

The techniques proposed for these projects comprise a variety of tools from analysis (spectral theory, variational methods), probability theory (stochastic differential equations, large deviation bounds) and mathematical physics (self-consistent equations). For the purpose of these projects, the tools mentioned above will be developed further.
Profiled sealing element for muff couplings - has three cylindrical rubber or plastic layers connected in S cross-section

The sealing element is made from rubber or thermoplastic material and is for stonework or earthenware pipes that are connected in line. Unlike the normal tar or oakhum seals, this design can be used for pipes of large diameter. The seal (1) has a cylindrical outer surface (3) and two inner layers (4, 5) connected together to form an S cross section. The outer part of the S is filled by the wall of the muff while the inner layer of the seal (5) presses onto the plain pipe end. Radial ribs (9, 10) keep the inner layer sealed against the gap between the h pipes. The front corner (8) fits over the muff and is reinforced at the leading edge.
Segregación Escolar por Nivel Socioeconómico en Educación Primaria en América Latina y el Caribe

Esta investigación tiene un doble objetivo: por un lado, estimar la magnitud de la segregación escolar por nivel socioeconómico en educación primaria en los países de América Latina y el Caribe y, por otro, contextualizar dichos resultados en el ámbito internacional. Para ello, se realiza una explotación de los microdatos del ERCE 2019, impulsado por la UNESCO/OREALC. La muestra final la componen 157.115 estudiantes de 7.214 escuelas escolarizados en 16 países de América Latina y el Caribe. Para estimar la segregación escolar se han utilizado los cinco índices más habituales. También se han comparado los resultados con los obtenidos por PISA 2019 para poder contextualizarlos. Los resultados muestran una gran variabilidad en los niveles de segregación escolar entre los países, pero con unos niveles de segregación escolar muy altos, así como grandes diferencias entre los estudiantes desfavorecidos y más favorecidos. La yuxtaposición con los resultados de PISA 2019 encuentra que América Latina y el Caribe es la Región del mundo con una mayor segregación escolar por nivel socioeconómico. Estos resultados urgen a priorizar la lucha contra segregación escolar en las políticas educativas públicas de la Región, así como fomentar la investigación sobre esta temática.
SUBSTITUTED AMINO ALCOHOLS

Disclosed herein are substituted amino alcohol anti-mycobacterial agents and/or chelation therapy agents of Formula (I), process of preparation thereof, pharmaceutical compositions thereof, and methods of use thereof.
Leveraging the environment of civil air transport with dohop

Nowadays there are many solutions for finding, comparing and booking flights. However, these solutions are based on pricing information, which can only offer pre-defined itineraries and does not disclose all the possibilities for connecting flights. This limitation is translated into fewer options for the users needing to connect flights (in some cases up to 30% of users cannot find a ticket for their route), thus restraining the benefits of airlines that are not selling all their tickets (only 70% of seat capacity is sold on some routes).Dohop is a mobile and web-based application that uses a unique approach; we use the schedule information provided by OAG , the most reputed airline schedules database, and pricing data from more than 400 sources. Our advanced algorithms process the data from OAG to build all possible alternatives for connecting two or more flights, thus providing more convenient or even hidden alternatives to users. Then, final prices are collected from our partner databases and shown in the app. This competitive advantage permits users to make their own connections between flights that were apparently not connected through other solutions – we call this quot;Self-Connectquot;. Besides the travellers, LETS provides benefits for: Low-cost carriers, using LETS as a support tool for creating interline networks without needing commercial agreements (around 800,000 € each per year) and increasing their sales around 2%-3%; and airports, optimising the traffic and PAX handling and thus increasing 2%-3% benefits by enabling interline connections in their operations with reduced costs (we estimate minimum benefits for airports of €8 million per year). Furthermore, savings in CO2 emissions are also boosted thanks to optimising the routes between airports.Through this project, we estimate a potential market of €10 million by 2020 and the creation of about 18 direct new jobs, plus 10-15 indirect ones.
Analysis of Competition Between Transformation Pathways in the Functioning of Biotic Abstract Dual Automata

Properties of avenues of transformation and their mutualism with forms of organization in dynamic systems are essential for understanding the evolution of prebiotic order. We have analyzed competition between two avenues of transformation in an A↔B system, using the simulation approach called BiADA (Biotic Abstract Dual Automata). We discuss means of avoiding common pitfalls of abstract system modeling and benefits of BiADA-based simulations. We describe the effect of the availability of free energy, energy sink magnitude, and autocatalysis on the evolution of energy flux and order in the system. Results indicate that prebiotic competition between avenues of transformation was more stringent in energy-limited environments. We predict that in such conditions the efficiency of autocatalysis during competition between alternative system states will increase for systems with forms of organization having short half-lives and thus information that is time-sensitive to energy starvation. Our results also offer a potential solution to Manfred Eigen's error catastrophe dilemma. In the conditions discussed above, the exponential growth of quasi species is curbed through the removal of less competitive "genetic" variants via energy starvation. We propose that one of the most important achievements (and selective edges) of a dynamic network during competition in energy-limited or energy-variable environments was the capacity to correlate the internal energy flux and the need for free energy with the availability of free energy in the environment.
Implications of signal intensity fluctuations on vector sensor array processing

Vector sensor processing relies on the covariance matrix for both a single vector sensor and a larger matrix from a vector sensor array. The elements of these covariance matrices have physical interpretation in terms of complex intensity. The presence of reactive intensity on the array shows up in the off diagonal elements of the covariance matrix and has significant implications on direction of arrival (DOA) algorithms. Sources of reactive intensity in an underwater waveguide are dependent on the geometry of the system and fluctuations in these quantities affect the ability to increase the array aperture to better resolve arrival angles.
Cooperative Target Tracking Control of Multiple Robots

This paper focuses on the problem of moving target tracking with a group of mobile robots. Each robot in the group has a pan/tilt camera to detect the target and has limited communication capability to communicate with neighbor robots. The problem is solved by separating it into two parts. One part is the estimation of target position and another is the flocking control of multiple robots moving toward the estimated position. In the target estimation part, we propose to use a novel distributed Kalman filter to estimate the target position. The distributed Kalman filter is deduced based on a standard Kalman filter by modeling the neighbor's information as one of measurements. In the motion control part, a distributed flocking algorithm is developed. It is used to track the estimated target and avoid collision. In both parts, only local communication between neighbor robots is required. Finally, the tracking algorithms are simulated with 2-D and 3-D robots to verify their performance. The simulation results provide a firm conclusion that the proposed algorithms are able to track a moving target. A group of real ground mobile robots is used to test the proposed algorithm. The experiment results show that multiple robots are able to cooperate to track the target under the proposed algorithms and the tracking result outperforms the result produced by individual robots without cooperation.
Dynamic road sign casting

The project has the objective to industrialize an innovative, flexible and cost-effective dynamic road sign system as a valid alternative to the actual static road sign infrastructure on expressways. 

The problem: Road signs in motorways sometimes do not reflect road conditions or properly inform drivers due to their static nature. In particular speed limits and road works signs often change due to different conditions and need to be replaced manually. This exposes road maintenance personnel to dangerous works and results in higher life-cost cycle per sign. 
The solution: An innovative low-cost, low-power, low-maintenance, and highly flexible “variable message road sign” based on paper-display technology and centrally controlled has been designed and prototyped that demonstrate less life-cycle costs and higher flexibility. Road Builders and maintenance authorities as well as system integrators for road infrastructures are a Potential Market. Preliminary assessments have been conducted that indicate a great potential of the innovation. The business potential of the solution could also extend to other markets (such as digital out of home) but the project will concentrate to transportation to maximize the probability of success of the initiative. 

The business approach. Customers have already been approached and more will be approached directly or via stakeholders and business partners from the actual portfolio of the proponents. Dissemination and marketing promotion will be carried out to achieve a critical mass of interested customers for the industrialization phase. Feasibility will also target pilot deployment with interested customers.

Objective of the feasibility study is to provide the basis for the solution and the business approach minimizing the risks for the proponents and the early adopters in the industrialization phase while augmenting the competitive advantage.
Ionic solvent-based recycling of polypropylene products

This project addresses the call topic CE-SPIRE -10-2018: Efficient recycling processes for plastics containing materials.

A method (ISOPREP) is proposed for recycling polypropylene (PP) products into virgin quality PP and hence reusable for the production of the highest grade PP products. The method exploits a novel ionic polymer solvent designed for highly tuned solubility of PP, patented within the partnership, with the key advantages/innovations:
(1) A performance identical to PP resin freshly manufactured from fossil sources
(2) Cost effective compared with producing PP from fossil sources
(3) Reduces the reliance of PP production on fossil resources
(4) Achieves a step reduction on life cycle emissions and energy compared with the use of fossil resources 
(5) Is entirely closed loop with negligible loss of solvent per cycle and hence negligible emissions thus non-polluting
(6) The solvent is non-toxic and non-flammable in the process temperature range
(6) Removes dyes, colours and impurities
(7) Prevents sending end of life PP products to landfill and avoids them polluting both land and sea

PP is used in a huge variety of products such as automobile interiors, consumer goods packaging, electronics, construction materials, carpets and other home furnishings. The global PP market, accessible by the ISOPREP system, was estimated at €65bn per annum in 2017, totaling approximately 23% of the entire plastics market. Given the typically short life of PP products, only 1% of which are recycled, there is a great need to implement innovative and disruptive technologies to mediate this trend.

Although applicable to a wide range of products, the concept will be developed and demonstrated at pilot plant stage for recycling polypropylene carpet at TRL7, based on prior and patented knowledge within the partnership at TRL5.