SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Perforin and Granzyme B Have Separate and Distinct Roles during Atherosclerotic Plaque Development in Apolipoprotein E Knockout Mice

The granzyme B/perforincytotoxic pathway is a well established mechanism of initiating target cell apoptosis. Previous studies have suggested a role for the granzyme B/perforin cytotoxic pathway in vulnerable atherosclerotic plaque formation. In the present study, granzyme B deficiency resulted in reduced atherosclerotic plaque development in the descending aortas of apolipoprotein E knockout mice fed a high fat diet for 30 weeks while perforindeficiency resulted in greater reduction in plaque development with significantly less plaque area than granzyme Bdeficient mice. In contrast to the descending aorta, no significant change in plaque size was observed in aortic roots from either granzyme Bdeficient or perforindeficient apolipoprotein E knockout mice. However, atherosclerotic plaques in the aortic roots did exhibit significantly more collagen in granzyme B, but not perforin deficient mice. Together these results suggest significant, yet separate roles for granzyme B and perforin in the pathogenesis of atherosclerosis that go beyond the traditional apoptotic pathway with additional implications in plaque development, stability and remodelling of extracellular matrix.
Micro-scale ORC-based combined heat and power system using a novel scroll expander

Micro-combined heat and power generation (micro-CHP) based on the organic Rankine cycle (ORC) is a flexible technology that allows saving the environment and promoting the economic growth. However, ORC expanders employed recently suffer from key problems including excessive fluid leakage, thermal losses and low isentropic efficiency, and no commercial micro-scale expanders are available in the market and applicable for ORC applications. The possibility of driving a micro-CHP system by solar thermal energy, biomass combustion, waste heat or other clean energy sources allows attaining diversity and security in energy supply as well as decreasing pollutants and gas emissions. In the current work, a solar- biomass-driven micro-CHP system based on the ORC technology is theoretically and experimentally investigated to provide the thermal and electrical needs for residential applications. The micro-CHP system employs an innovative micro-expander utilizing an environmentally friendly working fluid. A numerical model was developed using the Engineering Equation Solver (EES) software to simulate the thermal and electrical performance of the overall CHP system. A parametric study was conducted to investigate the effect of different operational parameters on the CHP system performance. In addition, an experimental set-up was built to test micro-scale ORC-CHP system performance under different conditions using hydrofluoroether (HFE)-7100 fluid. The maximum electric power generated by the expander was in the range of 500 W under a pressure differential of 4.5 bars. The expander isentropic efficiency has exceeded 80% at its peak operating conditions with no working fluid leakage.
HIstorical CAstle ParkS

Central Europe’s cultural heritage is rich and diverse, but under pressure due to lack of capacity (common policies, know-how, resources). In some parts situation is rapidly deteriorating. In the past, many castle buildings were upgraded, decorated with parks, which were reflections of the socio - cultural values of the time. Their purpose was to demonstrate the political and economic power of the owner and on the other hand owner wanted to spend quality time in aesthetic landscape. Nowadays many of those parks don’t exist anymore, especially in small towns. The main reason is lack of financial resources for the protection of cultural and historical buildings and their contents. Surrounding of the buildings, due to lack of knowledge from the past and financial resources, is therefore mostly arranged according to the needs of present days. We will strengthen capacities of public and private sector for use of cultural heritage and resources achieved through transnational cooperation, raise awareness amongst schools and citizens about our historical past and improve benefits for the citizens and the public administrations. Main outputs will be: Concept of TS, TS on evaluation of cultural heritage and potentials of historical parks, 8 local action plans, decision support tool  with guidelines for self-evaluation for local/regional development, educational outdoor trail tool and transnational handbook on landscape accessible for all, 8 local revitalisation concepts and 7 revitalised historical gardens and one 3D pilot visualisation. Due to the big varieties of typologies and the fragmentation in managing historical gardens at CE level, it would not be possible to tackle all these challenges in a single area. The diversity of the partners’ experience provides a transnational added value supporting a wide diffusion of the project results in many other CE regions.
Keyhole interlaminar dorsal rhizotomy for spastic diplegia in cerebral palsy

The efficiency and safety of dorsal rhizotomies for cerebral palsy lie in the accuracy of radicular identification together with selectivity of root sectioning. Two different exposures are currently in use. The first is extended laminotomy/laminectomy from the upper lumbar level to the sacrum, which allows accurate identification of all L2-S2 roots/rootlets. The second is limited laminotomy exposing the conus/cauda equina at the thoracolumbar junction; this less invasive method limits accessibility to the roots. To optimize the accuracy and selectivity while minimizing invasiveness, the authors developed a tailored interlaminar procedure targeting the radicular levels involved in the harmful components of spasticity directly and individually.Six patients with spastic diplegia at different levels of the Gross Motor Functional Classification System were selected. In each patient, two to three interlaminar spaces, preselected according to planning, were enlarged in the "keyhole" fashion, respecting the spinous processes and interspinous ligaments. Ventral root stimulation identified the radicular level. Dorsal root stimulation evaluated its implication in the hyperactive segmental circuits, helping quantify the percentage of rootlets to be cut.There were neither wound-related nor general complications. At 1 year of follow-up, X-ray examination did not reveal kyphosis or instability. In all children, the excess of spasticity was reduced. The Ashworth score decreased from 3.2 on average to 0.6 postoperatively (range: 2-4 to 0-2). Regarding the functional status at 1 year of follow-up for the three ambulatory children, the Gillette ability-to-walk score increased from 3/10 on average to 7.3/10 postoperatively (range: 2-4 to 7-8). For the three non-ambulatory children, abnormal postures, painful contractures and ease of care were much improved.Keyhole interlaminar dorsal rhizotomy (KIDr) offers direct intradural access to each of the ventral/dorsal roots, thus maximizing the reliability of anatomical mapping and allowing individual physiological testing of all targeted roots. The interlaminar approach minimizes invasiveness by respecting the posterior spine structures.
Womanspace: The underground and the labyrinth in Ursula K. Le Guin’s <i>Earthsea</i> narratives

Ursula K. Le Guin’s renowned Earthsea cycle, spanning 20 years and five texts, is often acknowledged to be a textual space for the creative exploration and interrogation of gender. The two spaces in the title – ‘earth’ and ‘sea’ – are held in equilibrium, both by the author’s craft and by magic. Unfortunately, though, few critics have explored how these spaces function in the narrative. In this article, we explore the representation of underground spaces and labyrinths as meaningful landscapes in the Earthsea cycle. These spaces are found throughout Le Guin’s Earthsea fiction, but are foregrounded in four narratives: ‘The finder’ and ‘The bones of the earth’ (Tales from Earthsea), The tombs of Atuan and The other wind. Le Guin’s writing consistently identifies the earth as feminine, in keeping with the archetype of ‘Mother Earth’, and we find that subterranean spaces and labyrinths are depicted as sites of power and empowerment for women. Nevertheless, we argue that Le Guin’s affinity for gender equity and balance prevents these tropes from becoming another tired revisioning of an easy equation of earthy forces and ‘the feminine’. Rather, for Le Guin, the underground and the labyrinth are sites of union between masculine and feminine elements and characters, through the empowerment of the feminine.
Color-Enriching nano coating for mobile displays

Mobile phones and tablets have become an indispensable part of our lives. Mobile device users make many transactions with mobile phones and tablets during the day such as; sending emails, taking photos, reading newspapers, playing games, watching movies etc. According to the research, mobile device users prefer devices that are comfortable to use, do not threaten eye health and provide high quality images. Especially with the trends such as mobile phone gaming taking over from console gaming, the display quality has been a very decisive criteria behind the customers’ buying decision.
While brands’ search on how to improve the display quality has been continuing, Quantum dot (QD) technology has created an atomic bomb effect among display suppliers. QD colour components are recognized as the next generation technology in displays. Display suppliers have begun to prefer the QD technology to improve color quality on screen when they discovered the advantages compared to existing technologies.
CoENCo Display is a disruptive method that enables QD technology to be used in mobile phone and tablet displays. With its innovative method, it achieves to offer a wider variety of colors from nature on mobile phones and tablets.
The global QD-based display market is expected to reach 9 billion USD in 2026 with a CAGR of 25.2%. Our target customers are quantum dot producers and component makers, which are the suppliers of brands like Samsung, Amazon and Apple. Our initial target markets are Germany and the UK.
We have two types of sales models: Type A: Non-Exclusive Licensing, Type B: Material sales. Our target is to generate a revenue of 106 million Euro per year and create additional employment of 35 people by creating local and international partnerships by the fifth year of market introduction.
Differential roles of NADPH oxidases and associated regulators in polarized growth, conidiation and hyphal fusion in the symbiotic fungus Epichloë festucae

The endophytic fungus Epichloë festucae systemically colonizes the intercellular spaces of temperate grasses to establish mutualistic symbiotic associations. We have previously shown that reactive oxygen species produced by a specific NADPH oxidase isoform, NoxA, and associated regulators, NoxR and RacA, have a critical role in regulating hyphal growth in the host plant to maintain a mutualistic symbiotic interaction. We also identified BemA and Cdc24, homologues of polarity establishment proteins of yeast, as interactors of NoxR. In this study, we investigated culture developmental phenotypes of 'knockout' mutants of noxA and noxB and their associated regulators, noxR, racA and bemA. On nutrient-rich medium, all of the mutants except racA, which had undulating hyphae, hyphal swellings and increased branching, had a colony growth phenotype similar to the wild type strain. In contrast, on water agar, noxA, noxR and bemA mutants had disorganized hyphal growth and distorted instead of straight hyphae. These changes in hyphal growth characteristics indicate that NoxA and associated regulators have a crucial role in polarized growth under conditions of nutrient starvation. Conidiation in the noxA mutant was greater than wild type, and further enhanced in the noxA/noxB double mutant suggesting ROS negatively regulates asexual development. In contrast, deletion of noxR had no effect on conidiation. Hyphae of the wild type and noxB mutant of E. festucae had frequent vegetative hyphal fusions, whereas noxA, noxR and racA mutants totally lost this ability and fusions in the bemA mutant were significantly reduced. These results indicate that NoxA, NoxB and their associated regulators have distinct or overlapping functions for the regulation of different hyphal morphogenesis processes.
Personal video recorder method and user interface

A method of recording and playing back contents to and from a personal video recorder (PVR) for audio-visual contents. The recorder comprises a storage medium ( 12 ). Information is presented concering the recorded content on said medium ( 12 ). Programmes of a first type of programmes are recorded on the storage medium ( 12 ), wherein the programmes are subscribed to by a user of the recorder. Programmes chosen by the user for viewing are played back. Programmes of a second type of programmes are recorded of said storage medium ( 12 ), wherein said second type of programmes is comprised in a user profile. Furthermore, a third type of programmes is recorded on said storage medium ( 12 ), wherein said third type of programmes comprises programmes being recommended by a broadcaster.
DEVELOPMENT OF CYBER-PHYSICAL SYSTEM FOR LASER-BASED CONTROLLED CLOUD SEEDING

This research encompasses of developing a cyber-physical system (CPS) i.e., a system which can control the physical process of cloud formation by utilizing the LIDAR technology to modulate its frequency while directed on aerosol cloud in order to control the movement of cloud, formation and precipitation in a test bed settings. This will enable studying the detailed effects of laser induced cloud nucleation and also in modeling the cloud behavior with respect to the feedback loop between induced affect through lasers upon the aerosol cloud. This involves utilization of advanced algorithms, image processing techniques to model cloud behavior and artificial intelligence to control the laser frequency modulation and pulse count, directed or incidence angle to understand the response between laser effects on aerosol cloud.
EARTH MOVING IMPLEMENT HAVING A REPLACEABLE CUTTING EDGE ASSEMBLY

1474360 Excavator teeth assemblies CATERPILLAR TRACTOR CO 14 Jan 1976 [12 May 1975] 01424/76 Heading E1F A replaceable cutting edge assembly for an earth-moving implement comprises cutting edge sections 22 and digging teeth 24. Each cutting edge section 22 has a wedge shaped portion 32 extending forwardly from the leading edge 12 of the floor of the implement and a flange 36 underlapping the floor, the flange and the Boor having aligned holes 28, 30 for receiving bolt means 26 for securing the cutting edge section 22 in place. Each cutting edge section 22 also has a rearwardly facing stepped surface 38 at the junction of the wedge shaped portion 32 and the flange 36, the stepped surface being spaced apart from the leading edge 14 of the floor. A tooth 24 is located at each juncture between adjacent pairs of cutting edge sections. Each digging tooth 24 has a rearwardly extending portion 14 that is shaped to overlap and abut against the wedge shaped portions of the associated cutting edge sections 22 and is provided with a tang 46 extending into and substantially filling the space between the leading edge of the floor and the stepped surfaces 38 of the two associated cutting edge sections. In a modified construction to that shown each tooth is also provided with a portion that extends rearwardly beneath both associated cutting sections as well as the floor and is apertured so that a tooth can be further secured in place by the bolt means 26 passing through said portion as well as the sections and the floor.
A MULTI-THRESHOLD TRANSMISSION GATE SWITCH AND AN ULTRA LOW POWER SEGMENTED DIGITAL TO ANALOG CONVERTER THEREOF

The present invention relates to an ultra low power segmented digital to analog converter (DAC) (100) using a plularity of multi-threshold transmission gate switches (110) for converting digital data into an analog signal. The ultra low power segmented DAC (100) of the present invention comprising a coarse divider string (120) having 2M or greater coarse resistor segments (121), a fine divider string (130) having 2N or greater fine resistor segments, and a plurality of multi-threshold transmission gate switches (1 10), wherein said multi-threshold transmission gate switch (110) comprises a parallel structure of two transistors (117, 118) and a serial structure of two transistors (115, 116) for minimizing the on-resistance and preventing current leakage of the switch.
The evolution of X chromosome inactivation in mammals: the demise of Ohno’s hypothesis?

Ohno’s hypothesis states that dosage compensation in mammals evolved in two steps: a twofold hyperactivation of the X chromosome in both sexes to compensate for gene losses on the Y chromosome, and silencing of one X (X-chromosome inactivation, XCI) in females to restore optimal dosage. Recent tests of this hypothesis have returned contradictory results. In this review, we explain this ongoing controversy and argue that a novel view on dosage compensation evolution in mammals is starting to emerge. Ohno’s hypothesis may be true for a few, dosage-sensitive genes only. If so few genes are compensated, then why has XCI evolved as a chromosome-wide mechanism? This and several other questions raised by the new data in mammals are discussed, and future research directions are proposed.
Valorisation of mushroom agrowastes to obtain high value products

The project aims at the valorization of agricultural residues coming from mushroom (Agaricus Bisporus) farming residues as a case to set up new cascading possibilities using innovative procedures to extract high value bio-based additives (antioxidants, antimicrobials, proteins), convert lipids into bioplasticizers and polysaccharides (glucans and fermentable sugars) into biopolymers using remaining side streams in substrates to close the agricultural cycle by composting and/or biogas synthesis. The funguschain project will demonstrate its industrial viability by building a new biorefinery that will use cost-effective extraction technologies (MAE and HWPE) revalorizing more than 65% of waste into valuable additives.

These additives will be incorporated into high added value products and industrially validated towards 3 key value chains in the European economy (food, cleaning and plastic sectors). Industrial lines from end-users will be modified and adapted to the developed products. These products are: food supplements for elderlies, cleaning products, novel biobased thermoplastic masterbatches, bioplasticizers and industrial film products (thin bags and gloves <15 microns, partially recycled thick bags >50 microns and mulching).

A business strategy to valorise the products in a collaborative manner will be designed, leading to safe, sustainable, economically viable and attractive products acceptable to consumers. Partners will ensure that products meet legal and market requirements. The project will forge and propel industries growing within the frame of the European bioeconomy, boosting the community network.

The consortium involves 16 partners (4 RTDs, 4 Large industry and 8 SMEs) accounting with 5 BBI full members and 3 associate members. Funguschain project has a duration of 48 months and a total estimated budget of 8,143,661 M€ plus 3,500,000M€ in additional activities dedicated to the construction of the DEMO biorefinery plant.
Method and system for retaining customer loyalty

A system and method for providing incentives to customers where the incentives are tailored to the customer's needs and expectations while achieving profitability to the provider are presented. The present invention determines a set of incentives based on customer segmentation, card segmentation, call type as well as other factors. Upon receiving a request for termination or other request, the customer may be routed to an appropriate person, department, or group. Information regarding the account may be identified and retrieved and the customer may be verified. Based on customer payment history and other information, the customer segment may be identified. Incentives are then determined based on customer segmentation data, product information, and call type. These incentives are offered to the customer for approval. If the customer does not accept the incentive, other sales opportunities may be offered to the customer in an effort to retain customer loyalty.
Improved estimation algorithms for water purification and desalination systems

Sustainable access to drinking water and providing usable water supply for adequate sanitation and also for irrigation based agriculture forms one of the major challenges for the global society in the 21st century. The major subject of the PURE-WATER project are water purification and desalination processes. As a crucial part of a functional water resource management system, the information processing and monitoring of the respective water filtration and refinement procedures are subject to high requirements for accuracy, real-time standards and reliability. From a system engineering perspective, major issues regarding the complex underlying physical principles are to gain an appropriate mathematical description of the dynamic behavior combined with an adequate parameterization and knowledge about the internal state conditions of the distributed processes via intelligent sensor data evaluation in spite of external perturbations. This is required for an efficient and safe water plant control setup. The consortium will work together on developing a robust and online implementable modulating function based estimation scheme that includes observers for nonlinear and distributed hydrodynamical systems with an additional fault detection and isolation concept to identify failing operational conditions such as membrane fouling impact. The designed methods are validated in simulation and an experimental test bench is developed for testing the designed algorithms in a realistic environment. Furthermore, a smart sensor configuration will be designed for joint measurement and data evaluation devices. This is accomplished by combining the expertise from academic partners on the fields of observer design as well as system modeling and simulation with the experience from industrial partners on waste water treatment, desalination and integrated sensor systems by exchanging knowledge between scientists from Europe, Latin America and the Middle East coordinated by EU members.