SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
FULLY-HUMAN POST-TRANSLATIONALLY MODIFIED ANTIBODY THERAPEUTICS

Provided are methods and compositions for the delivery of fully human post-translationally modified therapeutic monoclonal antibodies and antigen-binding fragments thereof. The fully human post-translationally modified therapeutic monoclonal antibodies may be preferably delivered by gene therapy methods, particularly as a recombinant adeno-associated virus (rAAV) vector to the appropriate tissue. Methods of manufacture of the AAV vectors, pharmaceutical compositions and methods of treatment are also provided. In addition, provided are methods of producing therapeutic antibodies that are "biobetters" as fully human post-translationally modified. These fully human post-translationally modified therapeutic antibodies may be administered to a subject in need of treatment with the therapeutic antibody.
The role of chromatin in the long-term adaptation of plants to abiotic stress

Abiotic stress is a major threat to global crop yields and this problem is likely to be exacerbated in the future. Therefore, it is very important to engineer crop plants with improved stress tolerance. A large body of research has focussed on the immediate stress responses. However, in nature stress is frequently chronic or recurring, suggesting that temporal dynamics are an important, but under-researched, component of plant stress responses. Indeed, plants can be primed by a stress exposure such that they respond more efficiently to the next stress incident. Such stress priming and memory may be particularly beneficial to plants due to their sessile life style. Typically, the memory of priming lasts for several days after the end of the stress. During the past few years, my group has initiated a molecular analysis of heat stress memory in Arabidopsis thaliana. Heat stress memory is associated with sustained gene induction and transcriptional memory and we have demonstrated that this involves lasting chromatin changes. The underlying molecular mechanisms, however, remain poorly understood. Here, I propose to combine mechanistic dissection of heat stress memory in A. thaliana with concomitant translation of the results into the temperate cereal crop barley. In particular, we will study the following questions: What is the role of chromatin during heat stress memory? How do the transcription factors involved mediate memory-specific outputs? How does nucleosome positioning affect heat stress memory? How do histone modifications during stress memory interact with transcription, chromatin and nuclear organization? Is heat stress memory conserved in temperate cereal species? Can we engineer plants with improved stress memory? Using existing tools and new methodologies, the proposed analyses will yield unprecedented insight into the long-term adaptation of plants to abiotic stress and open up approaches for breeding of stress-tolerant crops.
Stochastic Source Seeking by Mobile Robots

We consider the problem of designing controllers to steer mobile robots to the source (the minimizer) of a signal field. In addition to the mobility constraints, e.g., posed by the nonholonomic dynamics, we assume that the field is completely unknown to the robot and the robot has no knowledge of its own position. Furthermore, the unknown field is randomly switching. In the case where the information of the field (e.g., the gradient) is completely known, standard motion planning techniques for mobile robots would converge to the known source. In the absence of mobility constraints, convergence to the minimum of unknown fields can be pursued using the framework of numerical optimization. By considering these facts, this paper exploits an idea of the stochastic approximation for solving the problem mentioned in the beginning and proposes a source seeking controller which sequentially generates the next waypoints such that the resulting discrete trajectory converges to the unknown source and which steers the robot along the waypoints, under the assumption that the robot can move to any point in the body fixed coordinate frame. To this end, we develop a rotation-invariant and forward-sided version of the simultaneous-perturbation stochastic approximation algorithm as a method to generate the next waypoints. Based on this algorithm, we design source seeking controllers. Furthermore, it is proven that the robot converges to a small set including the source in a probabilistic sense if the signal field switches periodically and sufficiently fast. The proposed controllers are demonstrated by numerical simulations.
Dynamical effects on neutral excitations

The aim of the present project is the development of a theoretical tool for the description of neutral excitations that are directly probed in absorption, electron energy loss and inelastic X-Ray scattering experiments. It is focused on the description of dynamical effects beyond the quasi particle picture that are not taken into account in the present theories. The final goal will be the correct description of the spectrum in systems where dynamical effects are not negligible as metals and strongly correlated insulators, the description of multiple excitations that are not included in a quasi particle picture and the understanding of the role played by electronic correlations on the lifetime of neutral excitations. Particular attention will be devoted to the problem of the multiple excitations in strongly correlated transition metal oxides.
COMPOSITE CONSTRUCTION ELEMENT, IN PARTICULAR FOR THE MANUFACTURE OF COVERING STRUCTURES OR WALL STRUCTURES OF BUILDINGS

A composite construction element (1, 101) is described which may be used in the manufacture of covering structures or wall structures of industrial warehouses, housing and buildings in general, comprising a body (2) made of expanded plastics material provided with opposite faces (2a, 2b) and a slab-shaped coating element (5, 105a, 105b) associated to at least one of the faces (2a, 2b) of the body (2). The slab-shaped coating element (5, 105a, 105b) comprises a plurality of substantially adjoining and substantially U-shaped adjacent sections (6) provided with respective means for mechanically clinching (11) the slab-shaped element (5, 105a, 105b) to the expanded plastics material. Advantageously, the slab-shaped element (5, 105a, 105b) is stably associated to the mass of expanded plastics material by means of the mechanical clinching means forming part of the slab-shaped element (5, 105a, 105b) itself.
Network for co-productive development of sustainable urban mobility plans empowering cities to create joint visions, targets and sets of measures to manage their future city progress

CityMobilNet takes on one of the most prominent and EU-wide apparent policy challenges for Europe’s cities today: urban mobility.The European Commission underlines the importance of urban transportation due to the central role of cities for growth, employment and the welfare of citizens (over 80% of EU’s GDP is generated in cities). Cities need an efficient transportation system to come up to this essential role. But they face major problems and increasing inefficiency due to amongst others high loads of GHG emissions and costs arising from chronic congestions (up to € 80 billion per year).CityMobilNet faces these major problems of urban mobility by empowering cities to develop sustainable urban mobility strategies. It takes up the concept of Sustainable Urban Mobility Plans (SUMPS), which designs urban mobility development in a comprehensive and co-productive process for a time scope of 10-15 years. CityMobilNet adapts the concept of SUMPs to the diverse local needs of its cities by putting SUMP Integrated Action Plans in practise at the background of each cities’ mobility challenges and planning and participation background. The cities gain capacity and knowledge for a co-productive development of sustainable urban mobility strategies out of the network’s transnational learning and exchange activities. They will be able to use their new gained proficiencies not only for urban mobility strategies but for developing solutions and policies for all urban challenges.
Spin-Polarized Angle-Resolved Photoelectron Spectroscopy of the So-Predicted Kondo Topological Insulator SmB6

Undoped and slightly Eu-doped SmB6 show the opening of a gap with decreasing temperature below ~150 K. The spectral shapes near the Fermi level (EF) at 15 K have shown strong increase in intensity of a peak at a binding energy (EB) of around 12 meV with decreasing the photon energy (hn) from 17 eV down to 7 eV. Angle resolved spectra of SmB6 measured at hn = 35 eV just after the in-situ cleavage showed clear dispersions of several bands in the EB region from EF to 4 eV. Spin-polarized photoelectron spectra were then measured at 12 K and light incidence angle of ~50 deg. In contrast to the lack of spin polarization for the linearly polarized light excitation, clear spin polarization was observed in the case of circularly polarized light excitation. The two prominent peaks at EB~12 and ~150 meV have shown opposite signs of spin polarization which are reversed when the helicity of the light is reversed. The sign and the magnitude of spin- polarization are consistent with a theoretical prediction for the 6H5/2 and 6H7/2 states.
Next generation methods, concepts and solutions for the design of robust and sustainable running gear

The rail sector has recently seen only limited changes in running gear.The rail sector has recently seen only limited changes in running gear. A reason is that innovations have the tendency to increase the first cost of the running gear while they reduce the LCC by reduce maintenance costs. The long-term cost reduction, however, is not easy to quantify. 
This dilemma will be addressed in WP1 where an updated Universal Cost Model based on the one from the Roll2Rail project will be developed that makes it possible to judge the economic impact of the innovation suggested for an operator using the vehicle. How can the costs for buying, operating and maintaining the vehicle be influenced? 
Lower bogie weight would reduce wheel-rail forces and allow for higher payload. In WP2, the project is going to suggest ideas that are based both on the use of new materials and new manufacturing methods. Simulation techniques will be explored to allow optimisation of designs. It will be investigated whether required properties of the running gear such as stiffness and damping could be distributed through the structure rather than requiring specific components. In parallel, active control strategies will be investigated to improve the level of ride comfort or reduce wheel and rail damage. 
The wheelset is another extremely important and safety-critical component in a rail vehicle.  Since it represents a so-called “unsuspended mass” there is a desire to minimize the wheelset weight. The main objective of WP3 is a feasibility study on the use of composite materials for the construction of railway wheelsets. Technology concepts for a lightweight wheelset will be defined. Main focus areas are material selection, durability, manufacturing process and joining methods.
The output of this project will be important input for the parallel member project in IP1 both regarding the Cost Model and the technical innovations. There will also be a contribution to the overall S2R KPI’s and partly IP3.
The characterization of the distant blazar GB6 J1239+0443 from flaring and low activity periods

In 2008 AGILE and Fermi detected gamma-ray flaring activity from the unidentified EGRET source 3EG J1236+0457, recently associated with a flat spectrum radio quasar GB6 J1239+0443 at z=1.762. The optical counterpart of the gamma-ray source underwent a flux enhancement of a factor 15-30 in 6 years, and of ~10 in six months. We interpret this flare-up in terms of a transition from an accretion-disk dominated emission to a synchrotron-jet dominated one. We analysed a Sloan Digital Sky Survey (SDSS) archival optical spectrum taken during a period of low radio and optical activity of the source. We estimated the mass of the central black hole using the width of the CIV emission line. In our work, we have also investigated SDSS archival optical photometric data and UV GALEX observations to estimate the thermal-disk emission contribution of GB6 J1239+0443. Our analysis of the gamma-ray data taken during the flaring episodes indicates a flat gamma-ray spectrum, with an extension of up to 15 GeV, with no statistically-relevant sign of absorption from the broad line region, suggesting that the blazar-zone is located beyond the broad line region. This result is confirmed by the modeling of the broad-band spectral energy distribution (well constrained by the available multiwavelength data) of the flaring activity periods and by the accretion disk luminosity and black hole mass estimated by us using archival data.
Neurogenesis-Related changes in hippocampal new neurons and circuits after traumatic brain injury

Traumatic brain injury (TBI) affects millions of people representing a major public health concern, however, treatment options are limited. Even after mild TBI many individuals suffer from long term neuropsychological impairments such as memory loss and learning deficits. We hypothesize that some of the observed impairments are related to the alterations in adult hippocampal neurogenesis (AHN), the life-long capability of the hippocampus to generate new neurons from neural stem cells (NSCs). Alterations in AHN lead in turn to modifications of neuronal circuits and behavior. The hippocampus is essential for learning, memory consolidation and mood control and is highly vulnerable to TBI. We propose that the population of NSCs and the process of AHN is significantly altered, which might account for some of the symptoms associated with TBI. We hypothesize that TBI induces long term changes in, both NSCs and in differentiating neurons (inducing “aberrant” neurogenesis). As a result the electrophysiological properties of newborn and preexistent neurons in the hippocampal circuitry are changed, altering brain functioning. Proposed research is aimed at examining on how altered NSCs and “aberrant” neurogenesis impacts hippocampal neuronal activity after TBI. In proposed study we will combine neuron activity modification, quantitative neuroimaging anlysis and intracellular patch-clamp recordings in order to evaluate the effects of TBI on NSC proliferation, immature neuron number, and electrophysiological properties of post – TBI born neurons once they fully mature. We believe that the proposed research will contribute to better understanding the pathophysiology of TBI and that has the potential to help develop novel therapeutic strategies, targeting NSCs and newborn neurons, to improve the outcome of the millions of people impacted by TBI each year. The applicant will emerge from the project with new skills, and the experience to launch her own research group in the future.
Protecting species and ecosystems through dynamic and innovative transalpine ecological connectivities

"This project is part of the plan BIODIVALP":The project BIODIV'CONNECT aims to create a cross-border strategy for ecological connectivity in the Western Alps. The project will provide an overview of the current knowledge of ecological continuity and how they are taken into account in public policies in the ALCOTRA territory, in order to clearly identify priorities on to intervene. The project will then develop exchanges between partners with the aim of sharing the methods of identifying continuity and the good practices associated with them, in order to share and improve the knowledge of these continuities. With these elements, the project will formulate a cross-border strategy in this area and carry out restoration and conservation activities of some existing connectivity in the ALCOTRA territory.

The Western Alps Massif is the biogeographic and transboundary link of the ALCOTRA program. It rubs shoulders with both the summits and the Mediterranean basin forming a hotspot of biodiversity. Nevertheless, this exceptional natural heritage is vulnerable to the erosion of biodiversity and to global changes (fragmentation of environments, climate change, etc.). Based on this observation, a consultation process between the 5 Regions and the territorial actors has made it possible to draw up a framework ambition aimed at protecting and enhancing biodiversity and Alpine ecosystems through a partnership and a network of cross-border ecological connectivities. This ambition is articulated in two strategic objectives, contributing to the EUSALP strategy and the Alpine Convention, and aiming to (i) stem the erosion of ecosystems and protected species and (ii) enhance the attractiveness of the cross-border territory. The originality of the activities concerns the cross-border structuring of an integrated governance, the knowledge and the methodologies of management of biodiversity reservoirs, a public policy of ecological connectivities and a strategy of valorization of the biodiversity. In addition, the activities provide for the capitalization of various European projects (see point 5). The French and Italian partners of the plan include protected areas, communities, associations and chambers of commerce.
Bioorthogonal photocatalytic activation of metal-based prodrugs

New cancer care methodologies with fewer side effects and no need for major surgery are required to enhance patient wellbeing. Photodynamic Therapy (PDT) partially accomplishes such mission employing light and a photosensitizer. Nevertheless, the PDT mechanism of action intimately depends on oxygen, which limits its efficacy, particularly in hypoxic solid tumours. Promising strategies to improve the impact of PDT in the clinics currently involve the design of photoactivatable transition metal complexes, a class of compounds which combines the rich photochemistry of metal complexes with the vast background of metal-based drugs in cancer therapy.

In this framework, ORTHOCAT proposes an original and multidisciplinary strategy to exploit the efficiency and selectivity of riboflavin as unconventional photocatalyst for the activation of Pt(IV) anticancer prodrugs (Chem. Sci. 2017, 8, 4619). 

The project aims at designing novel riboflavin-based catalytic systems capable of activating Pt(IV) anticancer prodrugs inside the mitochondria of tumour cells. In particular, I will use triphenylphosphonium targeting vectors to develop new photocatalytic prodrug systems and delivery nanoplatforms which selectively accumulate in the mitochondria. Once in the organelle, riboflavin will act as singlet oxygen photosensitizer for PDT and simultaneously as photocatalyst to generate Pt(II) species for targeting mitochondrial DNA (photochemotherapy). Imbalance of mitochondrial delicate redox homeostasis by ORTHOCAT dual agents can trigger cell death through convenient cellular pathways. Therefore, ORTHOCAT prodrug systems will synergistically kill cancer cells with increased effectiveness, while potentially reducing side effects of metal-based drugs. Successful outcome of the project has the potential to deliver innovative therapeutic agents for cancer photochemotherapy.
Development in Adversity: South Africa’s Defence Industrial Participation in Perspective

Defence industrial participation (DIP) is a form of countertrade and falls in the sub-category of (defence) offsets. The South African DIP programme played a developmental role in the country’s defence industrial base (DIB), arresting its steady decline since the 1980s. This article discusses the perceived non-achievement of the 1997 DIP objectives and the reality of its manifestations over a 12-year period (2000–2012). It is argued that the DIP tripled the gross national product and improved the economy through the retention of some 58 000 jobs. However, the 2014 Defence Review paves the way for a new defence industrial dispensation. Notwithstanding, there is a need to explore the concomitant ambiguity that exists between perceptions of countertrade and offsets as trade-distorting practices and as value-adding prospects, and to ascertain how this reciprocal trade mechanism could be used better to promote the developmental aims and objectives of governments.
LOCAL Policies for GREEN Energy

The project will support Local Authorities to define and implement innovative local fiscal policies, intended to promote renewable energy sources (RES) both in the public and private sector and households, mainly in the framework of the Sustainable Energy Action Plans adopted by Local Authorities signatories of the Covenant of Mayors. 
In rural areas and islands of MED regions, local fiscal policies have a key role in incresing renewable energy sources. Since rural local authorities have economical and technical constraints, RES promotion plans should prioritize collaboration and active roles for private sector and households. Local fiscal systems are proper tools to lead and engage such actors in RES.
The project will support the testing of innovative local green fiscal policies, and monitoring their results in spreading renewable energy sources. As well, the project will facilitate capitalization of the best practices and application in other municipalities, at national and transnational levels, since models of green local fiscal policy will be elaborated and disseminated as well as technical support will be provided. The project will provide Local Authorities with fiscal policy models to be included in their own strategies and plans, especially in the framework of the Covenant of Mayors.
Green fiscal policies will promote public and private sector engagement in renewable energy sources, to increase the share of renewable local energy sources.
Does clinical supervision promote medical-surgical nurses’ well-being at work? A quasi-experimental 4-year follow-up study

The aim of the present paper is to report results of a quasi-experimental study exploring the effects of clinical supervision (CS) on the development of medical-surgical nurses' well-being at work over a 4-year period.Effective workplace interventions are needed to prevent stress and burnout. More robust scientific evidence is needed to confirm the restorative effects of CS in nursing.A questionnaire survey on the perceptions of work and health was conducted in 2003 and 2007 on 14 units of a Finnish university hospital where 19 CS group processes had been completed between 2004 and 2007.Improvement in job resources as well as reduction in professional inefficacy and psychological distress were found among nurses who received effective CS (n = 41), but were not present among the nurses who found their CS less effective (n = 43) or who did not attend CS (n = 82).The results provide robust evidence for the positive effects of CS on medical-surgical nurses' well-being at work.Stress is a developmental challenge in the professional growth of individual nurses. One option for management to sustain nurses' well-being at work is to develop a learning organization in the workplace making use of CS.
Improving Tourism Actions in Cadses Area

ITACA promotes a sustainable economic and spatial development based on a better integration of nature preservation and a careful economic utilisation of natural resources by eco-tourism. Most of the ITACA project territories are rich in wetlands and forests. The main aim of the ITACA project is to preserve these unspoiled areas from being damaged by unsustainable development. All partners of the ITACA project face the challenge of how to protect and develop their rich natural heritage. For this, an effective networking of preservation strategies and regional development policies is needed and new strategies which include economic, financial and juridical tools have to be used. Co-operation of the different regions should help to implement these measures.