SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
European Clusters and Regions for Eco-Innovation Network Plus

In 2006, 6 European regions (Rhone-Alpes, Andalusia, Baden-Wuerttemberg, Ile de France, Lombardy, and Malopolska) decided to work together to propose innovative financial instruments to support eco-innovation and SMEs at the regional level. The ECREIN network (European Clusters and Regions for Eco-investments Network) was created with the support of the DG ENV G3 Unit within the European Environmental Technologies Action Plan (ETAP).

At the end of this project (December 2007) the 6 regions decided to continue to develop their activities, aware that regional policies and actions must be efficient to implement the new, green, low carbon economy that Europe and the Earth need.

Indeed, the first ECREIN project clearly exposed the lack of knowledge, adapted tools and coordination between public and private sectors, and as a consequence, the difficulty for financiers to invest in this specific sector.

On the basis of a Charter, a work programme and a dissemination plan, the six partners wished to expand their network with new regions from other European countries. Their objective: develop tools and actions to implement innovative regional policies supporting eco-innovation and eco-businesses, easily adaptable to every European region.

The ECREIN+ project submitted to INTERREG IVC as a regional initiative project will associate 6 new regions coming from 5 new countries: Romania, Bulgaria, Sweden, United Kingdom, and Belgium. For a larger dissemination, the Assembly of European Regions (AER) will be an active partner and responsible for the communication Component of the project.

The project will be divided into 3 components: the management component lead by Rhone-Alpes, the communication component lead by AER and the exchange of experience component lead by Andalusia with 3 work groups related to the main issues of a regional eco-innovation policy (the market, governance and tools, and efficiency).
The 12 regions and the AER will participate in the kick-off meeting (in Sweden), the steering committees, the 3 conferences (in UK, Poland and France) and in several workshops. The ECREIN website (and other communication events coordinated by AER) will allow for broad dissemination of the project's actions and results (methodological kit, guides of best practices, policy recommendations and databases).
The very innovative results expected of ECREIN+ will be specific tools, concepts and approaches allowing European regions to develop high-level, efficient and adapted policies to support eco-innovation and eco-businesses.

The economic and environmental crisis requires innovation for genuine, sustainable development. The regional level is very well suited for effective action in this field because of the proximity to stakeholders and the ability of Regions to develop flexible, innovative and adapted policies. Thus the ECREIN+ project will be a good example of the implementation of the Lisbon and Gothenburg strategies.
Information security technology for applications : 16th Nordic Conference on Secure IT Systems, NORDSEC 2011, Talinn, Estonia, October 26-28, 2011 : revised selected papers

Invited Papers.-Designing a Governmental Backbone.-Internet Voting in Estonia.-Contributed Papers.-A Ring Based Onion Circuit for Hidden Services.-User Tracking on the Web via Cross-Browser Fingerprinting.-Comparison of SRAM and FF PUF in 65nm Technology.-Modular Anomaly Detection for Smartphone Ad Hoc Communication.-Mental Voting Booths.-Methods for Privacy Protection Considering Status of Service Provider and User Community.-The Security and Memorability of Passwords Generated by Using an Association Element and a Personal Factor.-Increasing Service Users' Privacy Awareness by Introducing On-Line Interactive Privacy Features.-Optimized Inlining of Runtime Monitors.-Identity-Based Key Derivation Method for Low Delay Inter-domain Handover Re-authentication Service.-Feature Reduction to Speed Up Malware Classification.-Rooting Android - Extending the ADB by an Auto-connecting WiFi-Accessible Service.-An Attack on Privacy Preserving Data Aggregation Protocol for Wireless Sensor Networks.-Disjunction Category Labels.-Visualization Control for Event-Based Public Display Systems Used in a Hospital Setting.-Exploring the Design Space of Prime Field vs. Binary Field ECC-Hardware Implementations.-
New Feature Presentation of Transition Probability Matrix for Image Tampering Detection

Extraction of discriminative feature is crucial to machine learning approach of image tampering detection. The state-of-the-art Markov transition probability feature is extended in this paper. We show that correlation between adjacent elements on the difference array of block DCT coefficients can be theoretically calculated and provides little information to the classification problem. We propose to decorrelate the variables and use the marginal distribution as feature in image tampering detection. The framework is applied to 1st and 2nd order Markov transition probability feature. Our experiment result shows the new presentation of the feature has competitive performance and greatly reduced dimensionality.KeywordsImage Tampering DetectionImage Splicing DetectionMarkov Transition ProbabilityMachine LearningPattern Recognition
Mechanisms of alternative pre-mrna splicing regulation in cancer and pluripotent cells

Alternative splicing of messenger RNA precursors is a prevalent form of gene regulation that greatly expands the coding capacity and regulatory opportunities of higher eukaryotic genomes. It contributes to cell differentiation and pluripotency and its deregulation promotes cancer progression, as evidenced by the frequent occurrence of cancer-associated mutations in splicing factors, which are also targets of anti-tumor drugs. Despite its prevalence and relevance, the underlying mechanisms of regulation remain poorly understood. This proposal aims to develop and apply systematic approaches that can allow us to carry out the equivalent of genetic analysis of splicing regulation in cancer and pluripotent cells. These technologies can help to unweave the complex network of functional interactions within the spliceosome and of the spliceosome with regulatory factors, exhaustively map the contribution of regulatory sequences and be used to investigate, with unprecedented detail, mechanisms of regulation for essentially any regulator or alternative splicing event operating in a particular cell line. Such approaches can offer a unique opportunity to address key unresolved mechanistic questions, including the molecular basis for positional effects of splicing regulatory factors (RNA Maps), the regulatory potential of the core spliceosome and the integration of alternative splicing with other cell regulatory programs. We will combine these approaches with biochemical and cellular assays to investigate detailed mechanisms of regulation relevant for the control of cell proliferation and/or pluripotency in cancer and induced pluripotent stem (iPS) cells. Progress in this area can contribute to reveal the molecular logic governing a key layer of gene regulation and has the potential to discover novel factors and regulatory circuits that trigger or modulate cell growth, differentiation and cancer progression.
Interpreting the Relationships Among Prosody, Automaticity, Accuracy, and Silent Reading Comprehension in Secondary Students

Although identified as a critical component of proficient reading in the primary grades, reading fluency (word recognition accuracy, automaticity, and prosody) is often viewed as less important beyond the early stages of reading acquisition. In the present study, 108 ninth-grade students were assessed to explore the relationships among word recognition accuracy, automaticity, prosody, and vocabulary with silent reading comprehension. Results found large correlations among the variables while regression analysis revealed that accuracy, prosody, and vocabulary explained from 50.1% to 52.7% of the variance in silent reading comprehension. Of note were the findings that word recognition automaticity did not contribute to silent reading comprehension although prosody was found to act as a partial mediator between automaticity and comprehension. Accuracy, automaticity, and prosody were found to form a highly reliable scale reflecting oral reading fluency. These findings contribute to the growing body of evidence suggesting that secondary students exhibiting appropriate prosody experience advantages in comprehension processing. The tandem theory of reading is introduced to explain the relationship between automaticity and comprehension.
Next-Generation urinary catheters for preventing catheter associated urinary tract infections: emphasis on antibiotic resistance

Indwelling urinary catheters are life-saving medical devices that are widely used in hospitals and nursing homes to relieve a patient from urinary retention and incontinence. However, prolonged use of these catheters in the urinary tract leads to a life-threatening and disturbingly common complication, called catheter associated urinary tract infection (CAUTI). CAUTIs are mainly caused by bacteria and affect nearly 10 million patients every year globally. This makes CAUTI responsible for 40% of all hospital associated infections and the costs for treating these infections exceed 100 million USD a year. Furthermore, the global threat of antibiotic resistance has made it extremely difficult to treat CAUTI via conventional antibiotics and has led to longer hospital stays for the patient and higher mortalities, especially among the ageing population. A strong need exists for new anti-infective catheters that can prevent CAUTIs by enabling a new function that prevents bacterial attachment onto the catheter surface. Such a device w ill offer several advantages such as, prevention of infections, reduced usage of prophylactic antibiotics, reduced risk of antibiotic resistant infections and faster recovery for the patient. A societal advantage of such an improved anti-infective catheter is the ability to control the rise of antibiotic resistant infections in the hospital and the community and reduce economic impact. Amferia AB has developed and patented a novel amphiphilic antibacterial material-a mesoporous elastomeric polymer, referred to as NANOELAST, that is able to target and kill bacteria rapidly upon contact. Of special interest is that the material has been proven very effective in killing numerous antibiotic resistant bacteria, prevent biofilm formation and without causing any harm to human cells. Amferia aims to evaluate the NANOELAST as the next generation urinary catheter for infection preventive care.
Persistence of behaviours in the Forced Swim Test in 3xTg-AD mice at advanced stages of disease

Forced Swimming Test (FST) models behavioural despair in animals by loss of motivation to respond or the refusal to escape. The present study characterizes the behavioural responses of 12-month-old male 3xTg-AD mice in FST as compared to age-matched no-transgenic (NTg) mice. Paradoxical results were consistently found from what would be expected from their BPSD (Behavioural and Psychological Symptoms of Dementia)-like profile. The comprehensive analysis of the ethogram shown in the FST considered the intervals of the test (0-2 and 2-6min), all the elicited behavioural responses (immobility, swimming and climbing) and their features (total duration, frequency of episodes and mean duration). Both genotypes showed equal number of swimming episodes and climbing attempts during the first interval, that resulted in high swimming times, short climbing and scarce immobility. Thereafter, the NTg mice showed a behavioural shift over time and the immobility response showed up. In contrast, all the measures consistently evidenced that 3xTg-AD persisted with the previous behavioural pattern. Genotype differences consisted in less number of episodes of immobility and swimming, and a low immobility time in favour of swimming. No differences were found in 'climbing' attempts. The behavioural response observed is discussed as a lack of ability of 3xTg-AD mice to shift behaviour over time that may result of poorest cognitive flexibility and copying with stress strategies more than behavioural despair per se.
SPACE SAVING SLIDING DOOR SYSTEM FOR INTERIOR USE

A space saving sliding door system for one or more pair of toilet cubicles or shower cubicles. The sliding door system comprises a top hung longitudinal rail (7), one or more slider junctions (20) spaced along the top hung longitudinal rail (7); one or more pair of sliding doors (4,5); a roller assembly (21) installed on the upper side of each sliding door (4,5); one or more divider panels (2); which separates the cubicles; each of the divider panels (2) connected to the top hung longitudinal rail (7) at right angles to the top hung longitudinal rail (7). Each sliding door (4,5) is individually suspended by a roller assembly (21), and slidable along the top hung longitudinal rail (7). In an opened position, each sliding door (4,5) is individually slided into the slider junction (20) and parked there. The cubicle would be in a closed position when the sliding door (4,5) is individually slided almost fully out of the slider junction (20).
AUTOMATED BANKING MACHINE

In an example embodiment, there is disclosed herein an apparatus comprising a first terminal that comprises a first display, a first wireless interface, and a first cash interface, and a second terminal that comprises a second display, a second wireless interface, and a second cash interface. Control logic is coupled with the first user interface and the second user interface and operable to control the operation of the first and second displays, first and second wireless interfaces, and first and second cash interfaces. A safe is coupled with the control logic, and the first and second cash interfaces. The control logic is operable to have cash selectively delivered from the safe to the first cash interfaces responsive to cash withdrawal transactions conducted at the first terminal and to the second cash interface responsive to cash withdrawal transactions conducted at the second terminal.
3.10 Alkaloid-Derived Auxiliaries: Ephedra Alkaloids

This chapter covers the synthesis and application of chiral auxiliaries derived from the Ephedra alkaloids. The first half of the chapter is focused on the biosynthetic origins of the Ephedra and their use in acyclic chiral auxiliaries: the use of Ephedra of β -hydroxyhydrazones as developed by Takahashi, asymmetric reductions catalyzed by Ephedra derivatives, Myers’ pseudoephedrine-based asymmetric alkylation, and the Abiko–Masamune chiral auxiliary for the creation of antialdol subunits. The section on acyclic chiral auxiliaries also briefly covers the use of Ephedra amides in the Tsuji–Trost reaction and in diorganozinc reactions. The latter half of the chapter addresses cyclic chiral auxiliaries including Meyers’ oxazolines, oxazolidines, Evans’ oxazolidinones, and other heterocycle systems.
Sharing and application of innovative strategies for seismic protection of masonry buildings

The seismic protection of buildings, for the protection of people, structures and contents, is a common problem in the area. A synergy of skills is proposed between productive (4 companies involved) and research (2 research bodies involved) sectors to promote innovation in structural consolidation interventions (aimed at optimized use of resources) and spread acquired knowledge and experience to increase the know-how and competitiveness of construction workers. The project focuses on existing brick buildings, mostly exposed to seismic risk. A joint study on the intervention strategies in use is foreseen to allow the definition of innovative strategies, based on the targeted use of modern fiber-reinforced composite materials for the creation of curbs tops, floor ties, reinforced plasters to apply outside the building. An entire building in full scale, and other accessory test samples, will be designed, built and tested for the optimization of materials, application and efficacy for such intervention strategies.
Digital cancer diagnosis platform

Chromition have developed innovative and disruptive digital cancer diagnostic platform. The platform uses Chromition’s innovative Luminspheres™ nanotechnology combined with spatial pattern recognition software to diagnose cancer.

Luminspheres™ are multicoloured fluorescent nanoparticles that are prepared from carbon-based precursors in water at low temperature using our proprietary and environmentally considerate process.

Luminspheres™ bioimaging probes when tethered to biological molecules of interest provide sensitive and non-invasive insight into biological processes and interactions with minimal impact on the system under investigation.

Chromition are working with the Manchester University NHS Foundation Trust (MFT), using the Luminspheres™-antibody biomarker conjugates to stain tissue samples.  The tissue samples are then analysed by Chromition’s digital platform, which is able to analyse multiple biomarkers in a short space of time using bespoke spatial pattern recognition software.

Chromition will use Luminspheres™ in Immunohistochemical Staining (IHC) to rapidly identify multiple biomarkers in a single image. The image will then be analysed by innovative software that facilitates fast and autonomous analysis of multiple samples across a clinical cohort.

The development of this technology will enable the identification and analysis of multiple biomarkers at a speed not currently possible using existing technology and relying on human sight. 

The success of this project has the potential to transform the way clinical pathology is practiced.

In this project the platform will be used to identify multiple cancer biomarkers in tissue samples from women with endometrial cancers. 

Utilising the Chromition method firstly for the identification of endometrial cancers, and using the results to tailor medical intervention, will have a significant impact on the cancer burden for women in the EU and globally.
Territorial impacts of Covid-19 and policy answers in European regions and cities

The Covid-19 pandemic has caused an unprecedented crisis of social, political and economic systems throughout Europe and the world. Since March 2020, European countries, regions and cities have taken diverse measures to try and contain the spread of the virus. These measures, while aiming at easing pressure on the health care systems, have had far-reaching impacts on many sectors of economic activity across the continent.

Covid-19 and the sanitary measures taken to contain its spread have various disruptive impacts on people’s lives and on how cities, metropolitan areas and regions function. Containment measures resulted in abrupt changes in the way people work, study, shop, socialise and move around. The outcomes of these measures have been detrimental in many ways, resulting, inter alia, in people losing their jobs or having to make ends meet with a reduced income, being socially isolated, and/or having to balance work and teaching their children at home.

But there might also be some gains in the wake of the pandemic. First tentative analyses show that digital transition could be accelerated, as the reinforced provision of digital services may result in long-term innovation[1]. Mobility patterns have changed as well since the lockdown periods. Already before the pandemic, cycling had been given a high priority by local and regional policymakers due to its environmental benefits. The pandemic has additionally boosted this development while passenger numbers in public transport plummeted by 70-90% in some major cities[2], which is also a huge challenge for sustainable transport policies. A growing number of European cities have started to supply their citizens with temporary cycling infrastructure (pop-up cycle paths), providing short-term adaptations to their mobility policies. It remains to be seen, though, if these makeshift measures can be transformed into permanent solutions and how and if they could contribute to the green transition of European regions and cities.

Policymakers at all levels of governance require territorial evidence to be able to develop policy measures to cope with the immediate effects of the pandemic in the short-term and to manage its long-term impacts. This applied research activity sets out to contribute to the delivery of such territorial evidence by analysing the geographical patterns of the Covid-19 pandemic from its onset until as far as possible into 2021.  In doing so, it will focus on the direct and indirect social consequences of containment measures, including their territorial dimensions, an aspect that has so far not been addressed by pan-European research at the regional and local level.
The Influence of the Heme Sixth Ligand on the Backbone Dynamics of an Endogenously Hexacoordinate Hemoglobin

The hemoglobin of the cyanobacterium Synechococcus sp. PCC 7002 (GlbN) protects the cell from reactive oxygen/nitrogen species.1 GlbN coordinates the heme group with two histidines in the absence of an exogenous ligand and undergoes an unusual post-translational attachment of the heme group to the H helix. GlbN is well behaved by NMR spectroscopic standards, making it an excellent target for structural and dynamic studies aimed at characterizing the differential lability of the axial histidines, the perturbations caused by the post-translational modification, and the effect of exogenous ligand binding. The structure of GlbN is largely unperturbed by the covalent heme-protein cross-link,2 but binding of diatomic ligands such as CO (to ferrous GlbN) and CN- (to ferric GlbN) induces the formation of a distal hydrogen bond network and causes a shift of the B and E helices. 15N relaxation measurements indicate that the differences in ps-ns dynamics between the proximal and distal sides of the heme cofactor are minimal and also independent of heme covalent attachment. Upon CO or CN- binding the us-ms timescale motions are enhanced in the B and E helices, suggesting that the preferential displacement of the distal histidine is due to the stability of the final bound state rather than an intrinsic bond strength difference. The implications of increased dynamics on the distal side of the pocket after ligand binding will be discussed in terms of ligand migration inside GlbN and related globins.1) Scott et al., Biochemistry, 2010, 49: 7000-7011.2) Pond et al., Biomolecular NMR Assignments, 2009, 3: 211-214.Supported by NSF grant MCB 0843439.