SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Polymers in the liver: metabolism and regulation

Metabolic diseases are a burden on the European population and health care system. It is increasingly recognised that individual differences with respect to history, lifestyle, and genetic make-up affect disease progression and treatment response. A Systems Medicine approach, based on computational models fed with individual patient data, has the potential to provide the basis for a personalised diagnosis and treatment strategy. The PoLiMeR consortium (Polymers in the Liver: Metabolism and Regulation) has identified the inherited, liver-related diseases of glycogen and lipid metabolism as the ideal starting point for innovative research training in personalised ‘Systems Medicine’. Our perspective opens possibilities for the application of novel drugs and diagnostic tools to a range of both rare and frequent diseases.

To advance diagnostics and treatment of metabolic diseases beyond the state-of-the art, a new generation of scientists is needed. The complexity of the metabolic network and its aberrant behaviour in disease require experts with a deep knowledge and understanding of Systems Medicine approaches. The lack of truly interdisciplinary researchers, trained in the three ‘pillars of Systems Medicine’ - experimental, computational and clinical research - severely hampers progress in this field. PoLiMeR aims to fill this gap and brings together clinical, academic, and industrial experts on inherited metabolic diseases, computational modelling of the entire human metabolism, organ-on-chip technology, and detailed metabolic profiling. Our mission is to train our Early Stage Researchers (ESRs) to become dedicated Systems-Medicine experts, who can seamlessly collaborate between computational and wet-lab environments, and between clinical, academic, and industrial environments. This training will enable them to become the future leaders in the field and eventually make the difference for the patients.
PLANT TREATMENT

This invention relates to the treatment of a plant whereby a plant growth regulant compound is administered to the root zone of the plant in order to regulate its vegetative growth and increase its productivity as well as minimizing alternate bearing.
A NEW BAYESIAN METHOD FOR FITTING EVOLUTIONARY MODELS TO COMPARATIVE DATA WITH INTRASPECIFIC VARIATION

Phylogenetic comparative methods that incorporate intraspecific variability are relatively new and, so far, not especially widely used in empirical studies. In the present short article we will describe a new Bayesian method for fitting evolutionary models to comparative data that incorporates intraspecific variability. This method differs from an existing likelihood-based approach in that it requires no a priori inference about species means and variances; rather it takes phenotypic values from individuals and a phylogenetic tree as input, and then samples species means and variances, along with the parameters of the evolutionary model, from their joint posterior probability distribution. One of the most novel and intriguing attributes of this approach is that jointly sampling the species means with the evolutionary model parameters means that the model and tree can influence our estimates of species mean trait values, not just the reverse. In the present implementation, we first apply this method to the most widely used evolutionary model for continuously valued phenotypic trait data (Brownian motion). However, the general approach has broad applicability, which we illustrate by also fitting the λ model, another simple model for quantitative trait evolution on a phylogeny. We test our approach via simulation and by analyzing two empirical datasets obtained from the literature. Finally, we have implemented the methods described herein in a new function for the R statistical computing environment, and this function will be distributed as part of the 'phytools' R library.
Regional disparities in cause-specific mortality in europe: the role of local context and national health policies

Current socio-epidemiologic theories often perceive mortality (health) inequalities as a given and largely ignore the fundamental questions concerning their origin. Furthermore, the majority of prior studies on international differences in mortality have focused on cross-country differences without taking into account substantial regional variation within national populations. REDIM goes beyond the state of the art through performing a large-scale systematic investigation of the reasons for persisting and emerging spatial disparities in mortality across European countries. The scientific output of the project is crucial for developing and coordinating health policies aimed at reducing geographical inequalities in mortality across and within European countries.

The project intends to quantify the degree of convergence/divergence in cause-specific mortality that occurs between subnational entities in Europe, and to identify determinants of these changes. REDIM focuses on two specific research questions:

1) How does the process of the general mortality decline diffuse across space, and what causes of death contribute most to this diffusion?
2) To what extent do national borders determine health borders?

REDIM will tackle these research questions through analysing cause-specific mortality patterns and trends at NUTS-3 and NUTS-2 levels across 19 European countries. Mortality indicators will be interpreted in conjunction with contextual variables capturing the effects of local context and national health policies.

The proposed research agenda is highly relevant to the context of the integration process within the European Union which strives to enhance coordination of policies to promote more equal access to all benefits and assets in society including health. Apart from expected ground-breaking scientific output, REDIM will provide advanced tools for evaluating the effectiveness of policies within the framework of the European Spatial Development Perspective.
EQUALIZER CIRCUIT IN AN ENVELOPE TRACKING INTEGRATED CIRCUIT

An equalizer circuit in an envelope tracking (ET) integrated circuit (ETIC) is disclosed. The ETIC (26) is configured to generate an ET voltage based on a target voltage (VTGT) for amplifying a radio frequency (RF) signal(s). Since the ETIC has inherent impedance and group delay that can cause distortion in the ET voltage, an equalizer circuit (24) is provided in the ETIC to equalize the target voltage prior to generating the ET voltage. Specifically, the equalizer circuit generates an equalized target voltage to offset the inherent impedance and a modified target voltage to mitigate the group delay. Accordingly, the equalizer circuit can output a processed target voltage, which can include the equalized target voltage and/or the modified target voltage, for generating the ET voltage. As a result, it is possible to reduce distortion resulted from the inherent impedance and group delay, especially when the RF signal(s) is modulated in a wide modulation bandwidth.
PD SERVICE S.R.L.

WE DEAL WITH THE DESIGN AND REALISATION OF EXHIBITION STANDS THE NS ACTIVITY CONCERNS THE DESIGN OF EXHIBITION STANDS FOR LEADING COMPANIES SUCH AS ANSALDOENERGIA, HITACHIRAIL STS, BAOSTEEL ETC. IN THE CONTEXT OF THE NS ACTIVITY WE FIRST USE SOME DESIGNERS AND DESIGNERS WITH WHOM WE MEET TO DISCUSS THE LAYOUT OF THE STAND. ONCE THE PROPOSAL HAS BEEN DEFINED WITH THE CUSTOMER AND WE HAVE HAD THE GREEN LIGHT FOR THE REALISATION, WE START A SERIES OF MEETINGS WITH THE NS PARTNERS WHO WILL REALISE THE STAND, IN PARTICULAR WITH THE CARPENTRY MANAGERS WHO WILL REALISE THE WOOD AND METAL PARTS, THE HEADS OF THE TECHNOLOGY PART REGARDING THE ELECTRICAL SYSTEMS, THE WHOLE PART OF TECHNOLOGY (LEDWALLS, AUDIO AND LIGHTING SYSTEMS, AND GRAPHICS. THE SPACES WE HAVE AVAILABLE TO DO THESE MEETINGS NOW WITH THE COVID 19 PROBLEM ARE ABSOLUTELY INSUFFICIENT, THE CAPITAL OF THE COMPANY IS HELD BY A FAMILY TRUST (TRUST PD).
An exact method for link parameter estimation in error benchmarking: an application to Phase II two-stage single arm oncology trials

Bayesian trial designs rely on the specification of a vague data prior to the determination of trial outcome. Phase II two-stage single arm oncology trials have a generally small sample size which may not provide the necessary amount of data to outweigh a misspecified or overly optimistic prior. To account for this issue, clinicians may wish to benchmark Bayesian errors with frequentist measures of trial validity, Type I and Type II errors. A confidence prior, reflecting the clinician’s confidence in the efficacy of the treatment before data accrual, is used to equate the errors across design strategies. An exact method, modelling both the inherent small sample size and multi-stage decision process of Phase II single arm trials, is presented for constructing the confidence prior.
Path controller design of a mobile robot based on T-S fuzzy sliding control

This paper proposed the path tracking design of a mobile robot based on Takagi-Sugeno (T-S) fuzzy modeling method and sliding mode control. The T-S fuzzy model is utilized to represent the equation of motion of the mobile robot, and the concept of parallel distributed compensation (PDC) is applied to design the T-S fuzzy controller. The stability of the system is guaranteed by linear matrix inequalities (LMIs) from Lyapunov approach. The sliding mode control (SMC) preserves the advantages of quick response and low noise. Therefore, the T-S fuzzy control combine the SMC enable a mobile robot system to possess better robustness.
AEMA Villes avec Marinas et Ports Plaisance: Politiques Públiques et Privées pour une Promotion Tourístique Integrée

In a Europe in which territorial competitiveness is a key element in local development, policies in this area must be more effective, especially in decision-making, and more innovative in finding solutions for managing tourism products, the environment and new types of leisure activities. The partners in this project are aware of this problem and have decided to search for new methodologies to improve organisation of their tourism facilities. A joint study is being carried out into possible solutions regarding strategic planning of land development. * To guarantee a process of sustainable land development by introducing policies and marketing tools based on quality principles. * To strengthen cooperation and the sharing of experiences between towns with marinas. * To carry out local cooperation initiatives to strengthen coherence between urban policies for sustainable development and public and private initiatives for promoting nautical tourism facilities. Expected results / Résultats attendus • Benchmarking on public and private territorial marketing policies in the territories involved. • Methodology manuals on the introduction of a system for recommending tourism services, and the integration of public and private policies for marketing towns with marinas. • Web sites describing the main tourism products and services, recommendations and forums for debate. • Improved competitiveness in services and economic activity through increased level of activities and opportunities for creating jobs. • Improved functioning of tourism services and better quality of tools for communication with users of pleasure boats. • Contribution to better integrated public land management, especially for coastal areas. • Greater public-private cooperation in the management of territorial marketing.
Renforcement de la compétitivité de Sato d.o.o. par l’investissement dans les nouvelles technologies d’impression d’étiquettes

Accroître la compétitivité du secteur de la production de chaussures en Croatie et dans l’UE. Développer les capacités existantes et accroître la production par l’acquisition de nouvelles machines de fabrication.
Fine-Tuning the inflammatory response following cardiac injury to promote cardiac regeneration

The pronounced inability of adult human/mammalian heart to regenerate causes millions of deaths following cardiac insult, particularly in the longer term. The extent and persistence of associated inflammation has been generally linked with adverse cardiac outcomes, including fibrosis, hypertrophy, and dysfunction. However, characteristics of the inflammatory response e.g. the maturity of resident macrophages and/or the activation status of infiltrating cells may differentially influence cardiac fibroblasts and, most importantly, cardiomyocytes, thus affecting cardiac regeneration, hypertrophy, fibrosis and dysfunction. Unraveling crucial parameters of such interactions in appropriate biological systems should confer decisive intervention potential in a serious health problem. In the past years we have studied in detail cellular and molecular players regulating pivotal events initiating or sustaining the progress to heart failure (HF) in mice and zebrafish and we propose here to combine the systems to globally study these interactions.
Verwertungseinrichtung von Grauwasser

Bei einer Einrichtung zur Verwertung von Abwasser, insbesondere Abwasser von Bade- und/oder Duschwannen, wobei Abwasser in einem Grauwassertank gesammelt wird, ist vorgeschlagen, dass der Abwasserstrom über eine Trennvorrichtung geführt wird, die klares Abwasser in den Grauwassertank und trübes Abwasser in die Abwasserkanalisation leitet.
Perovskite/Gaas hybrid structures: towards enhanced optoelectronic properties

OPTOHYB focuses on studying the carrier localization (CL) in a new hybrid structure namely halide perovskites/GaAs for photodetection application. Understanding the CL phenomenon in this hybrid structure could provide insights towards enhancing/controlling the optoelectronic properties. The idea consists of detecting and controlling the CL in the hybrid heterojunction and orient it towards photodetection devices. The phenomenon can be generated, either, randomly by strain, composition, size, and diffusion fluctuations, or, controllably by doping. The CL affects the bandgap (creating band-tails states and optical transitions) which affects the carrier lifetime. The experimental treatment of the phenomenon will be performed optically by the mean of steady-state photoluminescence (PL) and the time-resolved photoluminescence (TRPL) to evaluate the CL signatures. The obtained results will be correlated with morphological and structural observations to qualitatively understand the luminescence mechanisms in the new hybrid structure. To realize OPTOHYB's goal, for the first time, a quantitative study by modeling the PL features and the decay time will be performed using the Localized State Ensemble model (LSE) and the generalized model for TRPL. The newly obtained parameters will allow the control of the CL's evolution versus the ex- and/or in-situ conditions. The successful execution of this proposal will create a new platform with controllable band-tail state formation and carriers dynamic related to the CL phenomenon. Therefore, slowing the charge carrier lifetime due to the carrier hopping between different states in the band-tail, which is beneficial for photodetection. Finally, the fabrication of a photodetector based on halide perovskites/GaAs heterostructure prototype will be performed. The efficiency of the prototype will be checked regarding the possible engineering of the CL and its effect on the prototype and the way on how we can exploit it.
Secure connected trustable things

Creating trust in wireless solutions and increasing social acceptance are major challenges to achieve the full potential of the Internet of Things. SCOTT, with 57 key partners from 12 countries (EU + Brazil), will provide efficient solutions of wireless, end-to-end secure, trustworthy connectivity and interoperability to bridge the last mile to the market (TRL 6-7).

SCOTT focusses on wireless sensor & actuator networks and communication in mobility, smart infrastructure and health, thus addressing essential European societal challenges and significantly contributing to burning issues such as Automated Vehicles or Industry 4.0.

SCOTT is based on 15 industrial use cases with a focus on cross-domain applications and heterogeneous environments, emphasizing 5G and cloud computing aspects. It uses a standardized multi-domain reference architecture, fully compliant with ISO 29182, which fosters reusability, scalability, and interoperability.
Nearly 50 reusable technical building blocks will be developed and utilized, proving cross-domain sharing of trustable wireless technologies and services. Finally, more than 20 tangible demonstrators will be presented all over Europe to a broader public.

Following a user-centred design to put security and privacy really in the hands of the user, SCOTT will build up and apply a dedicated Trusted System Development Framework to significantly foster acceptance of SCOTT solutions on the market, including the creation of an unprecedented, standardisable ‘privacy labelling’.

SCOTT covers full value chains from silicon to end-users/operators showing full vertical integration. Via reference implementations and open innovation approaches as well as close cooperation with AIOTI and other cluster organizations, SCOTT will establish an attractive, long-term eco-system.
Ultimately, SCOTT will foster Europe’s independence for security enabling components and systems and will further boost the growing “internet economy”.
Molecular adhesion and interactions in the nervous system

Surface-attached proteins establish cell-to-cell contacts and generate signals to control development and function of tissues. It is not clear how protein structure and interactions organize into intercellular assemblies to regulate signalling and adhesion. Using a hybrid approach and focusing on two cell-signalling systems critical for nervous system function, I will determine how protein conformation, interaction and spatial arrangement form cis and trans assemblies to control intercellular adhesion and signalling.

In the mammalian nervous system where intricate intercellular connections are highly abundant, two protein interaction systems play essential roles and have been studied extensively on a cellular and in vivo level:
1. Notch receptors with Jagged and Delta-like ligands in neurogenesis and neuronal plasticity
2. Contactins with Casprs, Neurofascin and Amyloid Precursor Protein in formation and maintenance of the nervous system. 
In addition, Notch signalling triggered by Contactins promotes cell maturation and interlinks these two signalling systems. The detailed molecular-level structures and interactions, however, remain largely unresolved and, consequently, our understanding of how Notch and Contactin conformational and oligomeric changes trigger cell signalling and adhesion is limited. 

The overall aim is to resolve the extracellular interactions of adhesion and the molecular mechanisms underlying signalling in the Notch and Contactin systems. 

I will combine X-ray crystallography and cryo-EM to determine structures of proteins, complexes and higher-order assemblies in the pre- and post-intercellular state, and use biophysical and cellular methods to probe cis and trans multivalent interactions. This will provide the molecular basis of intercellular communication and a stepping stone for the development of therapeutics to treat Notch and Contactin associated neurological disorders and cancers.
Pharmacogenetics from ethno-cultural perspectives

Advances in genetic technology have focussed on how genetic polymorphisms may impact on drug metabolism, response, adverse effects and clinical outcome. As drug handling and response is significantly driven by genetic factors, genotyping holds promise for personalised medicines. However, high genetic variability and multiple drug effects present a significant challenge to provide useful guidelines in clinical practice. In addition, the expressions of polymorphic genes that control neurobiological functions and drug metabolising enzymes are also influenced by environmental and dietary factors. With the increasing accessibility and affordability of genotyping, predicting clinical efficacy and adverse effects in individuals from diverse backgrounds holds greater potential. Further research into the pharmacogenetic differences from cross-ethnic perspectives may increase our understanding of the effects of genetic variants on drug efficacy and tolerability. This is likely to enable more rational psychopharmacotherapy that can minimize adverse effects, enhance efficacy, improve adherence and save costs in the long term. DOI: 10.4038/sljpsyc.v1i2.2569 SL J Psychiatry 2010; 1 (2):29-31
Environmental conflicts through the lens of artwork and multimedia in waterscape transforrmations

The fellowship aims at establishing the applicant as an expert in the study of environmental conflicts through training in the interdisciplinary fields of (gendered) water justice and data-intensive social science at the University of California Berkeley. I will analyse artworks produced in water-related ecological distribution conflicts (EDC) in which transformative or restorative initiatives operate under violent conditions.
The use of artworks in EDC has not been theorised enough although they are crucial to elicit the valuation languages held by local populations, this being a main tenet of ecological economics, and more generally of the environmental social sciences. I will conduct empirical research on the gendered use in EDC of artistic creations (films, plastic arts and songs), connected multimedia, and supporting ICTs, at two levels: a) case studies drawing on activist knowledge of EDC over wetlands and over coal (both water-related) under diverse contexts of violence in Colombia and California; and b) databases on artworks, and on social media, from EDC in countries where there is violence against environmental defenders (e.g., Philippines and Brazil). The research and associated training will innovatively use mixed methods, combining in-depth case studies, ideal for developing causal explanations, with data-intensive social science research methods such as big-data extended ethnography, which provide grounds for generalisation.
CLAMOR will address environmental justice issues that are of relevant for Europe and will build up a large database of artworks used in EDC at the global level. The action contributes to two H2020’s societal challenges and reinforces the European Innovation Partnership on Water, and the Water Justice Action Group in particular. Knowledge will be reintegrated at the Universitat Autònoma de Barcelona through postgraduate teaching and supervision, and by establishing a distinctive line of research on arts and environmental conflicts.
Computer-assisted hip joint resurfacing method and system

A hip resurfacing CAS system for guiding an operator in altering a femoral head in computer-assisted surgery for subsequent implanting of a femoral head implant, comprises a trackable reference on the femur. A registration tool is trackable. A bone-altering tool is associated with a resurfacing of the femoral head. A tracking apparatus tracks the tools. A resurfacing processing unit is connected to the tracking apparatus so as to receive tracking data for the tools. The resurfacing processing unit has a position/orientation calculator to calculate from the tracking data a position and orientation of the trackable reference to track the femoral frame of reference, and of the registration tool and the bone-altering tool. A model generator receives position and orientation data of the registration tool to produce a model of the femoral head and neck with respect to the femoral frame of reference. A resurfacing evaluator determines an evaluated bone resurfacing alteration as a function of a position and/or orientation of the bone-altering tool with respect to the bone model of the femoral head and neck, and a tool geometry model, at least prior to resurfacing being performed.