SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Deciphering transcriptional regulation of nf-kb target genes using integrative omics approaches

NF-kB is a family of transcription factors that regulate expression of genes that are involved in various cellular processes such as apoptosis, proliferation and differentiation. The NF-kB pathway is implicated in the initiation and progression of cancer and cancer cell drug resistance. Unfortunately, global NF-kB inhibition is harmful to the immune system; therefore, inhibition of a subset of NF-kB target genes that are linked to malignant transformation would be more appropriate. Different NF-kB target genes display distinct transcription activation kinetics, indicating that the molecular mechanisms driving expression of NF-kB target genes are strikingly diverse. Thus, it is highly interesting to study the factors that are involved in transcriptional activation of individual NF-kB responsive genes, both from a fundamental and clinical perspective. Here, we will develop two innovative strategies based on CRISPR/Cas9 based genome targeting combined with mass spectrometry-based technology to isolate single NF-kB target gene promoters upon NF-kB pathway activation and identify their constituents. We will also apply a complementary approach, ATAC-sequencing, to identify transcription factors that are involved in activation of NF-kB responsive genes. Moreover, we will study the underlying mechanisms and characterize the function of proteins that interact with NF-kB responsive promoters. Finally, the described mechanisms discovered in cancer cell lines will be verified and validated in small intestinal organoids, a non-transformed cell model for homeostasis in the intestinal epithelium. This ambitious and multidisciplinary project will greatly benefit from my expert knowledge regarding the NF-kB pathway combined with the expertise of the host laboratory in mass spectrometry and genomics. The project is expected to have a major impact in the research area of gene expression regulation in general and molecular cancer research focusing on the NF-kB pathway in particular.
Drug-Free antibacterial hybrid biopolymers for medical applications

There is a general consensus that biomedical polymers of natural and synthetic origin should and will play a very important role in the development of new therapeutic strategies to treat diseases. Due to resistance of bacteria to drugs, infection has become one of the toughest problems in the medical world as there are hardly any effective antibiotics left in the fight against many pathogens. This project aims to develop new therapies through a new combination of technology (a) development of new hybrid polymers with antibacterial functionality,(b) introduction of inhibitors that can permanently deactivate bacteriological proteases and (c) new formulations of bioactive ceramics and glasses that have specific charge potential to prevent bacterial growth. The challenge is to develop new medical polymers that have an intrinsic antibacterial functionality to achieve clinical effectiveness in the field. To develop the challenge to practical medical solutions, a new generation of industrial professionals is needed. They should have a solid multidisciplinary background complemented by the required academic and industrial experiences. The objective of this network is to train young PhD researchers to fill this demand in the strategic area of drug-free antibacterial hybrid biomedical polymers. This EID programme will achieve this by a joint training programme of world class academic and industrial institutes who will provide hands-on training in state of the art research projects related to key fundamental issues that determine the future new therapies of antibacterial biomaterials. The goal is to develop professionals that will play a pivotal role in pushing forward this challenging and knowledge-intense field for the coming decades to benefit the European economy, bring state-of-the-art technology to industry with advanced products for hospitals and personal health care and contribute to the development of therapeutic strategies to improve the quality of life.
Mapeamento de Tecnologias Ambientais: Um Estudo sobre Patentes Verdes no Brasil

Currently the Brazilian patent system works as a driver for economic and sustainable development, acting as a type of inductor for innovation of environmental issues. A fact observed in the relationship between green technologies and the patent system is in the form of the Pilot Programme for Green Patents of the National Industrial Property Institute [INPI]. But do green patents developed in Brazil meet the areas of greatest need? And which Brazilian regions do stand out? Using as research the patentometrics method, this article aims to identify the level of utilization of green technologies, using technological mapping of green patents conceded by the INPI. The analysis of research on green patents made it possible to draw a perspective on technology areas, regions and authors who hold green research in Brazil. It was found that the areas with more deferred green patents are directly related to the investments made by the companies in each sector of interest. The identification by region nade South and Southeast atand out, and it is observed that the higher investment in education and scientific and technological infrastructure, the greater the results of development of green research. It is hoped that the paper will contribute to the expansion and understanding of industrial property in the form of green patents.
Early detection and progress monitoring and prediction of corrosion in aeronautic al alloys through calibrated ultrasonic corrosion sensors application

Corrosion is a dynamic process in which propagation rate remains difficult to predict and varies depending on the type of corrosion occurring (pitting, intergranular, exfoliation,filiform, corrosion-fatigue and SCC). Currently, the presence of corrosion damages may be detected by means of NDT. However, corrosion initiation and mechanism behind the defect cannot be distinguished by currently used methods. As consequence, an early detection of corrosion is not done and corrective actions are only performed when become relevant (cracks, loss of thickness). Therefore, aircraft industry needs sensors able to detect both corrosion initiation and its propagation. Combined with predictive models, it will allow forecasting how damage progresses when paint is degraded.
The main objective of U-CROSS is to design, develop and validate the application of ultrasonic corrosion sensors (UCS), combining passive (Acoustic Emission) and active (Pulse Echo Ultrasonic Testing) types, for corrosion monitoring, enabling them for real time detection of early stages of localized corrosion as well as for monitoring the progress of damages with time. 
A well-defined strategy will be followed to validate its implementation by the development of “model witness blocks” to calibrate sensors, taking into account the intrinsic features of each corrosion mechanism. A thorough selection of the UCSs to be used as cumulative and real-time monitoring will be done depending on corrosion mechanism, and tests will be performed on several indoor and outdoor test rigs.
The project will also provide a software tool (wizard type) to enable end-users to design and use sensors and to predict the number of cycles before critical damage occurs.
3 research organisations, 1 NADCAP accredited SME for testing painted parts and 1 European leader in UCSs manufacturing and ultrasonic inspection join forces in U-CROSS to achieve these ambitious objectives, which will guarantee the future commercialization of the result.
Land-use and sustainable development of territories of mediterranean area

The object of the project is to develop a monitoring and evaluation system of land use based on commons criterias between the European partners of the network.  The main aim is to increase the capacity of public administrations (mainly city-hall) in charge of planning territory and land use to change their way of doing and managing that drove to an enormous consumption of soil in the last 20 years, and to adopt land use policies and management respectful of sustainable development criteria.
Reframing the Periphery: Narrative Authority and Self-Reflexivity in Mathieu Kassovitz’s La Haine

This article takes a narratological approach in examining how Mathieu Kassovitz’s La Haine (1995) establishes itself as an authoritative voice in framing the banlieue. It argues that framing is essential in establishing the film’s narrative authority, the idea that it is recounted from a position of experience. To do so, the film juggles two contradictory narrative impulses: a sense of critical distance which propels the film to its finale; and an emphasis on what Ross Chambers would call loiterliness, as the film tracks the wanderings of its trio of protagonists. By concentrating on three key storytelling sequences—the opening and closing voiceovers, as well as a story told by an elderly Jewish man which will be read self-reflexively—it will be argued that the key means through which the film adopts an insider’s perspective is through its affinity with Hubert, a character often overlooked in writing on the film.
Serious Games for Cyber Security Education

Phishing is an online identity theft that aims to steal sensitive information such as username, passwords and online banking details from its victims. Phishing education needs to be considered as a means to combat this threat. This book focuses on a design and development of a mobile game prototype as an educational tool helping computer users to protect themselves against phishing attacks. The elements of a game design framework for avoiding phishing attacks were used to address the game design issues. The mobile game design aimed to enhance the user's avoidance behaviour through motivation to protect themselves against phishing threats. A think-aloud study was conducted, along with a pre- and post-test, to assess the game design framework through the developed mobile game prototype. The study results showed a significant improvement of participants' phishing avoidance behaviour in their post-test assessment. Furthermore, the study findings suggest that participants' threat perception, safeguard effectiveness, self-efficacy, perceived severity and perceived susceptibility elements positively impact threat avoidance behaviour, whereas safeguard cost had a negative impact on it.
Microstructure and microhardness evolution of a Mg83Ni6Zn5Y6 alloy upon annealing

The microstructures and the corresponding microhardness evolution of a Mg(83)Ni(6)Zn(5)Y(6) (at.%) alloy subjected to a series of heat treatments were investigated. In addition to the 14H long period stacking ordered (LPSO) phase, a diamond-cubic phase with the possible space group of Fd (3) over barm and lattice parameter of a = 0.73nm were identified in the as-cast alloy. The combination of LPSO thin lamellae and the nanometer-sized cubic phase leads to a relatively high Vickers microhardness of about 116.2 +/- 13.7. When annealed at 473K and 573 K, the above diamond-cubic phase partially transforms to its structural variant, Fm (3) over barm, together with a slight change of lattice parameter (a = 0.72 nm). Precipitation of hexagonal Mg(2)Ni lath also happens at these moderate annealing temperatures. The remarkable increase of microhardness at this stage is believed to result from the strengthening of precipitates and the resultant coherent interface between the precipitates and their surrounding medium. When annealed at temperatures ranging from 673K to 773 K, the Mg(2)Ni precipitates were dissolved, grain coarsening in the alloy occurred, Fd (3) over barm phase completely transformed to its Fm (3) over barm counterpart, and consequently microhardness of the alloy was decreased significantly. (C) 2011 Elsevier B. V. All rights reserved.
PENGARUH RISIKO USAHA TERHADAP RETURN ON ASSET (ROA) PADA BANK UMUM SWASTA NASIONALGO PUBLIC

The purpose of the research is to determine where variable LDR, IPR, NPL, APB, IRR, PDN, and BOPO simultaneously or partially have significant toward ROA on go public private national banks.Data collecting method used in this research is secondary data source from quarterly financial statement from banks. Financial statement appendix researched from first quarterly financial statement 2010 until second quarterly financial statement 2013. data analysis technique used in this research in multiple regression analysis, F-test and T-test. Research determination criteria are four on go public private national bank shaving total asset up to 20 trillion until 60 trillion at second quarterly 2013. Based on those criteria then samples used are Bank Artha Graha Internasional, Bank Ekonomi Raharja, Bank Mega. Research period started first quarterly 2010 until second quarterly 2013.The result of research shows that LDR, IPR, NPL, APB, IRR, PDN, and BOPO have significant influence simultaneously to ROA on go public private national banks. LDR, NPL, APB, and PDN partially have negative insignificant influence toward ROA in national private go public banks. IPR, IRR partially have positive insignificant influence and partially have negative insignificant influence toward ROA on go public private national banks. BOPO partially have negative significant influence toward ROA on go public private national banks
Key words :Business Risk and ROA
Medieval hydrotechnology: an interdisciplinary case-study of water management in the historical and physical landscape of messinia, south greece

The HYDROMEDIE project will examine a series of key issues using innovative methods from landscape archaeology. The principal challenge will be to examine the strategies used for water management in different societies of medieval and post-medieval Messinia, comparing late Roman, Byzantine, Frankish, Venetian, Ottoman and early modern techniques in a series of case-studies. 

Previous research has not succeeded in differentiating and dating water-related infrastructure on a large scale, and this comparative analysis requires application of innovative techniques including GIS-based HLC and spatial analysis, 3D recording and analysis of surviving structures, micromorphological analysis of mortar, and scientific dating of samples using radiocarbon AMS (atomic mass spectroscopy) and OSL (optically-stimulated luminescence). 

The Fellow will be trained in all these areas through one-to-one instruction, tailored training courses, on-the-job learning and secondments. The training will provide skills necessary for a successful future career in the highly interdisciplinary fields of landscape research and medieval archaeology. 

The project fieldwork and sampling will focus on case-studies where the natural supply of water is insufficient for basic subsistence, necessitating use of water collection and storage technologies. The subsequent interpretation will seek to identify the social and cultural implications of different strategies, including not only the economic value of water but also the ideological or even religious implications. With this in mind, the case-studies will embrace a range of landscapes, including examples with fortifications, ecclesiastical sites and agricultural settlements.
SYSTEM, METHOD AND APPARATUS FOR DETECTING A FORCE APPLIED TO A FINGER

A system for detecting an amount of force applied to a finger where the back upper portion of the finger is illuminated by light. The system includes intrasubject and intersubject registration. Another embodiment relates to using linear discriminant analysis to generate a fingertip force model and obtain a force measurement. In other embodiments, the system is used to mimic the input of a mouse, a track/touch pad, a keyboard device, or control a robot. In other embodiments, the system is used to assist in physical therapy, medical diagnosis, medical studies, or contact measurement.
THE EUROPEAN URBAN EXPERIENCE

The Humboldt University of Berlin undertook a study
presenting, synthesizing and discussing recent and current
academic research on the implementation of URBAN
in different European countries and cities.
The study addresses 3 major issues:
> URBAN and governance: impact of URBAN on (national,
regional and) local governance structures and dynamics
(impact on domestic policy traditions and institutional and
administrative local structures; responses of domestic actors
at all tiers of government to pressure emanating from URBAN
to adjust existing urban policy contents, patterns and
instruments to EU requirements; translation of EU norms and
requirements into the local context; conflicts and bargaining
processes between different actors and interest groups, etc.)
> URBAN and local empowerment: URBAN’s potential
to empower the subnational level and local actors (URBAN
and experimentation with innovative policy approaches,
URBAN as a potential opportunity for local residents
to become involved in urban development, etc.)
> URBAN as a transnational programme: exchange and
policy learning offered through the transnational dimension
of URBAN (and URBACT); comparative approaches of URBAN
experiences in ’Northern’ and ’Southern’ Europe, in countries
and cities with longer experience in decentralized and
integrated urban policy making and those with centralized,
authoritative and top-down policy traditions, in different cities
in one country; potential “learning processes” discernable
from URBAN I to URBAN II.
A TORQUE DEVICE FOR OIL FIELD USE AND METHOD OF OPERATION FOR SAME

A torque device (1) and operational method for oil field use that includes a first torque device member (10) that has an operational axis (34) of rotation, and where a first torque actuator (42) is pivotally connected to the first torque device member (10) at a first radial distance (46) from a centre line (48) of the first torque device member (10), wherein a rod (50) or a second torque actuator (66) is pivotally connected to the first torque device member (10) at a second radial distance (54) extending in the opposite direction relative the first radial distance from the centre line (48), and where the first torque actuator (42) is pivotally connected to a first portion (56) of an actuator support (58), and where the rod (50), alternatively the second torque actuator (66), is pivotably connected to a second portion (60) of the actuator support (66), and where the actuator support (66) is radially movable relative the operational axis (34), but is restricted from rotating in a plane (XY) that is perpendicular to the operational axis (34).
Sustainable MED Cities

Energy efficiency improvement is a key strategy to reduce the environmental impact of public buildings. But usually energy efficiency plans do not fully exploit the potential for synergies that groups of buildings might offer. Energy efficient measures and their implementation at neighbourhood level (i.e. district heating, PV installations, etc) are showing clearly that a building scale approach is not optimal in reaching significant and cost-effective improvements. However at neighbourhood scale, decision making processes and the design of the intervention are more complex. Many EU projects addressed this issue proposing different methodologies, tools and indicators. CESBA MED intends to test 10 of them and to select the most affordable and operational solutions. On the base of the test results' evaluation, a common sustainability assessment framework at urban scale, a set of 8 regional assessment tools (CESBA MED SNTool) and an innovative decision making process will be defined to support the development of energy efficiency plans for public buildings in the context of their surrounding neighbourhoods. CESBA SNTool will allow to produce the MED Passport to compare the performances of buildings and neighbourhoods, in line with the EC COM 2014 445. A CESBA MED network of cities will be set up to maximise results' transferability. Training courses and workshops will be organized in the MED area. The project will be part of the European CESBA initiative.
Karst educational-naturalistic route especially equipped also for blind people 

In the wooded area of Basovizza the project will set up a highly technological route specially equipped for blind, visually impaired, disabled and physically impaired people. The Igouza wood is often visited by excursionists, sportspeople and elderly persons because of its level ground; moreover it is crossed by forest routes and trails, and it is easy to reach from Trieste on public transport. The trail named after Josef Ressel crosses an area reforested by the Austrians foresters, who had established here, since 1830, the centre of activities for the reforesting of the entire Trieste Karst area. This itinerary unwinds therefore along the historical trails and connects them to the routes which have been recently set up by the corps of foresters. Basovizza is today an important centre for scientific research, host to the Research Area of the Synchrotron Light Laboratory, hence the idea to implement a low environmental impact advanced technology along this route. Thanks to the cooperation of the Regional Branch of the Blind Association, it was possible to adopt along the trail an innovative infrared technology that allows, through a system of transmitters and receivers, the fruition of vocal information (in Italian, English and Slovene) on the direction and environmental and historical peculiarities of the surrounding territory. The route winds its way for a total length of around four kilometres, connecting Basovizza with the Lipica stud farm, where horse therapy has been available to the blind for several years. Specifically, the project contributed to make the Italian section of the trail accessible, for a distance of around two km.
METHOD, DEVICE AND SYSTEM FOR TRANSFERRING DATA

A method and system for transferring encrypted data from a first electronic device to a second electronic device. The method includes the steps of displaying a first encrypted two‐dimensional code at the output interface of the first electronic device, reading the first encrypted two‐dimensional code with the input interface of the second electronic device, and decrypting the first two‐dimensional code with the second electronic device, generating a second encrypted two‐dimensional code with the second electronic device, and displaying the second encrypted two‐dimensional code on the output interface of the second electronic device, reading the second two‐dimensional code encrypted with the input interface of the first electronic device and decrypting the second two‐dimensional code with the first electronic device and generating an action on the first electronic device based on the second decrypted two‐dimensional code. The second two‐dimensional code is a plurality of two‐dimensional codes.
Mediterranean Experience of Eco-Tourism

The project in brief_x000D_
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According to the World Tourism Organization, eco-tourism is a major trend with a growing demand of consumers for packages which offer responsible travel to natural areas, conservation of the environment and improvement of the well-being of local people. The Mediterranean area is the one of the most interesting regions in the world in terms of eco-tourism potential. The high diversity of landscapes and ecosystems together with the unique socio-economic and cultural mosaic provide suitable conditions for the development of ecotourism. _x000D_
In order to foster the diversification of tourism offer and a better seasonal distribution of tourism flows, MEET aims to develop an integrated strategy boosting eco-tourism at Mediterranean level. _x000D_
_x000D_
Specific objective_x000D_
_x000D_
To develop an integrated strategy in order to settle an eco-tourism development model for the Mediterranean area that boosts a better seasonal distribution of tourism flows, starting from the “European Charter for Sustainable Tourism” approach, through the establishment of a network amongst supply-side stakeholders (Natural Parks).