SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Next generation digital mems loudspeakers by usound

USound GmbH designs, develops and markets highly integrated micro-loudspeakers based on a new piezoelectric MEMS (Micro-Electro-Mechanical System) technology. USound, founded in 2014, is based in Graz, Austria, with offices in Vienna, Austria, San Francisco, USA and Shenzhen, China. USound has been growing fast from the start, with a current headcount of 58 people. USound’s revenue model is based on a high-volume sales of MEMS loudspeakers on a B2B basis to OEMs or other manufacturers of audio equipment. 
USound’s Vision is to be at the forefront of the digital transformation of the loudspeaker market. By 2020 USound will be a recognised design house for innovative and high-quality acoustic system solutions based on the unique features of the MEMS technology. USound will achieve this by pursuing a fabless business model, concentrating on its core technological competences: audio and MEMS technology, ASIC integration and manufacturing know-how, as well as IP protection and exploitation (37 patent families filed). 
The loudspeaker is the last component which has not yet been digitised, due to technical restraints. Therefore, loudspeakers are difficult to integrate in the manufacturing flow, which causes manifold problems for manufacturers of micro-electronic devices. The piezoelectric digital MEMS loudspeaker technology of USound makes fully automated manufacturing possible, while also improving sound quality, reducing the form factor and power requirements. 
The first product (in-ear phone) with USound loudspeakers inside will be marketed internationally by USound’s client 3nod. So, the market readiness of the first USound product “Ganymede” has been proven, but USound has realized that the piezo MEMS technology has not yet been exploited to its full capacity. “Kore” is now the next generation, which will bring a  leap in exploitation of the technological potential. This will be achieved by a break-through in the MEMS design and the level of electronic integration.
Tailoring the electrode-enzyme interface for efficient bioelectrochemical co2 reduction by formate dehydrogenase

The main objective of this proposal is to optimize the enzyme-electrode interface to achieve efficient bioelectrochemical carbon dioxide (CO2) reduction by formate dehydrogenase (FDH). To achieve the overall goal of the proposed project, the specific objectives are: 1) Incorporation of an unnatural amino acid (UAA) to Molybdenum-containing FDH (Mo-FDH) such that the enzyme can be specifically and covalently attached to electrode surfaces with controlled orientation for improved electron transfer (ET) 2) Tailoring the bio-interface between electrodes and FDH H for facile electrocatalysis by direct ET (DET) or mediated ET (MET). This includes the design electrode surface with pyrene moieties/mediator for directing orientation of biocatalysts on electrode surfaces. 3) Bioelectrosynthetic CO2 capture with electrochemical systems exploiting UAA-FDH H. For this, the prepared UAA containing Mo-FDH based biocathodes will be coupled with a hydrogenase bioanode to provide a complete enzymatic biofuel cell (EBFC) producing formate (HCOO− )and simultaneously producing electrical energy from molecular hydrogen (H2) and CO2. 
The project will be conducted in 3 work packages associated with research objectives. An UAA will be introduced to FDH H for the first time, yielding an approach for site-specific functionalization of complex metalloenzymes with this project. The proposed technology is highly attractive because it presents a promising solution to tackle global climate issues and energy concerns by providing improved green conversion of CO2 to chemical fuels. 
This project will be undertaken within the group of Professor Ross Milton (University of Geneva, Switzerland) and a secondment of two months is planned with Prof. Jason Chin (MRC Laboratory of Molecular Biology, Cambridge, UK) in order to develop skills in UAA incorporation.
DIFFERENT SECURE DATA DEDUPLICATION APPROACHES FOR CLOUD STORAGE: A REVIEW

With the fast growth of the current era, world are moving to digital storage for accomplishment purposes, there is a rising demand for systems that can deliver safe data storage in effective manner. As more corporate and private users outsource their data to cloud storage providers, new data breach incidents make end-to-end encryption progressively prominent obligation. With the growing awareness of data privacy, more and more cloud users choose to encrypt their sensitive data before outsourcing them to the cloud storage. Data deduplication is single instance data storage widely used in cloud storage system to reduce space and upload bandwidth. Duplication-less storage system which de-duplicates the data using file level deduplication and block level deduplication. In this paper we gives an overview of the state of data Deduplication approachesand describes the various application to produce specification according need of current generation.
An Extensible Neuroimaging e-Repository for Clinical Trials of Paediatric Brain Tumours.

Novel imaging techniques are playing an increasing role in tumour characterisation, assessment and management. However, incorporating imaging data into clinical trials presents a number of challenges in terms of quality control, standardisation in data collection, interoperability of widely used archiving systems and extensibility of imaging software architectures. Additionally, currently available monolithic applications cannot fulfil the diverse and rapidly changing needs of the clinical imaging research community. This paper discusses the limitations of the current CCLG Remote Data Entry (RDE) system and introduces the prototype of an alternative modular system based on the Extensible Neuroimaging Archive Toolkit (XNAT). The modular nature of the presented prototype promotes incremental software evolution and allows for flexible system customisation to suit the needs of individual imaging centres.
High throughput computing for accelerated photovoltaic material discovery: from material database to the new generation of photovoltaic materials.

This proposal combines synergistically the predictive power of quantum mechanical calculations with a high throughput framework for the accelerated photovoltaic material discovery. The main objective of the project is the creation of a material database that contains no crystalline-complex materials, which can be potential candidate for the development of a new generation of photovoltaic material. The robustness of the project is reinforced by the secondment of Onyx solar which will synthesis and characterize the most promising candidates to validate the methodology and optimize the process. The collaboration between ICCRAM researchers and facilities and the experience of the fellow in this multidisciplinary field guarantee the ideal conditions for the success of the research and the development of new methodologies, infrastructures and knowledge that are highly linked to the roadmap described in Horizon 2020
docrep: A lightweight and efficient document representation framework

Modelling linguistic phenomena requires highly structured and complex data representations. Document representation frameworks (DRFs) provide an interface to store and retrieve multiple annotation layers over a document. Researchers face a difficult choice: using a heavy-weight DRF or implement a custom DRF. The cost is substantial, either learning a new complex system, or continually adding features to a home-grown system that risks overrunning its original scope. We introduce DOCREP, a lightweight and efficient DRF, and compare it against existing DRFs. We discuss our design goals and implementations in C++, Python, and Java. We transform the OntoNotes 5 corpus using DOCREP and UIMA, providing a quantitative comparison, as well as discussing modelling trade-offs. We conclude with qualitative feedback from researchers who have used DOCREP for their own projects. Ultimately, we hope DOCREP is useful for the busy researcher who wants the benefits of a DRF, but has better things to do than to write one.
Liderança Feminina: Um Estudo Qualitativo com Mulheres Líderes em Imperatriz-MA / Female Leadership: The Challenges of Women in Organizational Leadership

Resumo: Este trabalho tem como objetivo de pesquisa compreender quais os dilemas das mulheres em cargos de liderança na cidade de Imperatriz-Ma. A pesquisa relaciona o que foi constatado na literatura pesquisada junto a amostra coletada na cidade. A metodologia do trabalho é qualitativa, que contou com a participação de 7 (sete) mulheres entrevistadas. Nos resultados, todas as mulheres consultadas apontaram para dificuldades da liderança feminina, onde o principal problema se relaciona no machismo sofrido nos ambientes de trabalho, assim como diferenças de salário mesmo que ambos os gêneros tenham as mesmas funções (cargos); as estratégias de enfrentamento encontradas foi o profissionalismo, enfrentamento via conversa e punições administrativas. Conclui-se, na perspectiva deste trabalho que é necessário refinar os canais de denúncias, outra questão interessante é a construção de uma sociedade mais tolerante nas diferenças por intermédio da educação, fazendo a edificação de paradigmas sociais cada vez mais voltados ao respeito e na equidade.Abstract: This work research aims to understand the dilemmas experienced by women in leadership positions in the City of Imperatriz-MA.The research is related to what was found in the literature analised though a sample of data collected in the City. The methodology of this work is quantitative which includes the collaboration of seven women interviewed. The results obtained show that all the women consulted pointed to the difficulties of female leadership, where the main problem is related to the sexist and discriminatory suffered in the workplace, as well as the salaries differences even though both genders perform the same functions and positions. However, the coping strategies found were through the professionalism, conversation, and administrative punishment. The conclusion in this work points out that there is a need to refine the channels of complaints, the perspective of this study shows the interesting question about the construction of a Society with more tolerance, through an educational process, building social paradigms based and focused on respect and equity.Keywords: Leadership. Female. Dilemmas.
A qualitative study of the career decisions of astrophysicists: relocation, life-work balance, and reputations (astromoves)

The number of members of underrepresented groups (including women & Eastern Europeans for the EU) participating in science, technology, engineering, and mathematics continues to be of concern at the local, national, and international level including it being a priority of MSCA. The issue of underrepresented groups participating fully in astrophysics has been a long-standing concern of astrophysicists worldwide. Astrophysicists recognize the importance of mobility in building a scientific career, but social science research revealed that women astrophysicists have to move more often & stay abroad longer to achieve the same career rank as men (analysis has not been done for astrophysicists embodying other forms of underrepresentation). ASTROMOVES examines the careers of astrophysicists (men, women & the gender diverse), their career decision-making and the role of mobility. 50 astrophysicists (European or worked in Europe) more than 8 years past their doctorate (>two career relocations), will be interviewed using semi-structured interviews focused on each of their career moves & their underlying decision-making process. Of interest is if their decision-making includes perceptions of scientific reputation, discrimination/bullying, family friendliness & career enhancement and how each astrophysicist ranks these. Training includes learning the latest qualitative analysis software for analysing the interviews and the latest visualization techniques for showing career moves consecutively. The research results will inform policies to support & enhance the careers of underrepresented astrophysicists with broader implications for STEM in Europe. Project deliverables include peer-reviewed articles, scholarly presentations, public lectures & a documentary film. The project will be based in the STIS department at UEDIN, proximate to the UK Royal Observatory. My career goal is to obtain a position in an interdisciplinary department similar to STIS.
Systems-level analysis of age-related macular degeneration reveals global biomarkers and phenotype-specific functional networks

BackgroundAge-related macular degeneration (AMD) is a leading cause of blindness that affects the central region of the retinal pigmented epithelium (RPE), choroid, and neural retina. Initially characterized by an accumulation of sub-RPE deposits, AMD leads to progressive retinal degeneration, and in advanced cases, irreversible vision loss. Although genetic analysis, animal models, and cell culture systems have yielded important insights into AMD, the molecular pathways underlying AMD's onset and progression remain poorly delineated. We sought to better understand the molecular underpinnings of this devastating disease by performing the first comparative transcriptome analysis of AMD and normal human donor eyes.MethodsRPE-choroid and retina tissue samples were obtained from a common cohort of 31 normal, 26 AMD, and 11 potential pre-AMD human donor eyes. Transcriptome profiles were generated for macular and extramacular regions, and statistical and bioinformatic methods were employed to identify disease-associated gene signatures and functionally enriched protein association networks. Selected genes of high significance were validated using an independent donor cohort.ResultsWe identified over 50 annotated genes enriched in cell-mediated immune responses that are globally over-expressed in RPE-choroid AMD phenotypes. Using a machine learning model and a second donor cohort, we show that the top 20 global genes are predictive of AMD clinical diagnosis. We also discovered functionally enriched gene sets in the RPE-choroid that delineate the advanced AMD phenotypes, neovascular AMD and geographic atrophy. Moreover, we identified a graded increase of transcript levels in the retina related to wound response, complement cascade, and neurogenesis that strongly correlates with decreased levels of phototransduction transcripts and increased AMD severity. Based on our findings, we assembled protein-protein interactomes that highlight functional networks likely to be involved in AMD pathogenesis.ConclusionsWe discovered new global biomarkers and gene expression signatures of AMD. These results are consistent with a model whereby cell-based inflammatory responses represent a central feature of AMD etiology, and depending on genetics, environment, or stochastic factors, may give rise to the advanced AMD phenotypes characterized by angiogenesis and/or cell death. Genes regulating these immunological activities, along with numerous other genes identified here, represent promising new targets for AMD-directed therapeutics and diagnostics.Please see related commentary: http://www.biomedcentral.com/1741-7015/10/21/abstract
TOTAL HIP ARTHROPLASTY USING CT-BASED NAVIGATION SYSTEM FOR A CASE WHO HAD MULTIPLE HARDWARE AROUND ACETABULUM FOR THE TREATMENT OF PREVIOUS ACETABULAR FRACTURE: A CASE REPORT

Objective The optimal positioning of the acetabular component is a relevant prognostic factor in total hip arthroplasty (THA). Because of substantial errors of manual technique in cup placement even with experienced surgeon, computer aided navigation system has been developed in recent years. However, existence of the hardware around acetabulum likely deteriorates the accuracy of the navigation system, namely in revision THA case and postoperative status of pelvic fracture. Here we report a case who we successfully performed THA using CT based navigation system although there were multiple hardware around acetabulum due to osteosynthesis for the previous pelvic fracture. Case presentation A forty-one years old man presented with intolerable hip pain with severe radiographic osteoarthritic findings in left hip joint. He had sustained left pelvic fracture and posterior hip dislocation due to traffic accident and undergone osteosynthesis using multiple plates and screws when he was forty years old. However, progressive collapsing of femoral head and acetabulum occurred. Then, we indicated THA for his situation and planned to apply the CT based navigation system (Stryker CT based hip Ver.1.1 softwear and Cart II system). Preoperative workup revealed incomplete union of posterior and superior acetabular wall and we had to retain plates and screws for the stable fixation of acetabular cup. The existence of the hardware made it complicated to perform three dimensional planning and templating. Meticulous surface editing of pelvis to exclude the metal artifact and fibrocartilagenous tissue was needed to achieve accurate surface registration. In the operation room, we had to use unusual way of registration to complete two steps of registration. In the first step (roughly matching between patient9s physical pelvic surface and edited pelvic surface in work station using corresponding 5 points), we utilized head of screw and hole of the plate which we could easily identify intraoperatively, in addition to ASIS and innominate groove. In the second step (strict matching using more than 30 points of pelvic surface), we had to identify the pelvic bony surface, as excluding the metal surface and fibrocartilagenous tissue such as fracture callus. These efforts enabled us to accomplish substantial accuracy of registration with RMS of 0.5 mm. Final cup orientation at the end of surgery was 41° of inclination and 25° of anteversion. Postoperative CT scan revealed that cup placement angle was 40° of inclination and 25° of anteversion, almost identical with intraoperative value. Conclusion Our experience showed that CT based navigation system provided accurate placement of the acetabular component in a case having multiple hardware as well as in normal primary THA. Although we need additional efforts such as meticulous preoperative planning, extra operation time, CT based navigation system has great advantages to minimize the mal-placement of the cup in complicated case.
An edible and biodegradable, zero sugar straw to accompany cold drinks or cocktails, preventing plastic residues.

SORBO MJV SL has developed a unique biodegradable, edible and flavored straw to substitute plastic straws, a residue which generates an important environmental and health impacts in life of population.

The original sugar sustainable straws do not modify the taste or color of the drink, as the constitutive material was developed from a genuine SORBOS formula with the right rigidity, durability and stability. However, the market is now demanding repeatedly a sugar-free option, representing a huge challenge as the formulation and the equipment required must be radically modified.

The plastic straw is useful only for a few minutes and often end up escaping into waterways. The production and distribution of plastic has a huge carbon footprint, which is exacerbated because so many plastic products are designed to be disposable and are destined for the landfill after just one use. However, tons of them reach the oceans where marine birds and wildlife become entangled, or choke on our plastic waste, or mistake it for food. 

The edible straw from SORBOS could help reduce the amount of plastic in oceans and save millions of fish and other marine life preventing the introduction of toxins in the human food chain. It should be considered also post-drink snack and promptly a functional food when adding vitamins and nutrients.Sugar-free SORBOS will be the first healthy, edible and aromatized straw in the market, 100% biodegradable and respectful with the environment with personalization in terms of aroma, flavour, colour and size and using and innovative complex production process first in class.
Brain–computer interface and semantic classical conditioning of communication in paralysis

We propose a classical semantic conditioning procedure to allow basic yes-no communication in the completely locked-in state as an alternative to instrumental-operant learning of brain responses, which is the common approach in brain-computer interface research. More precisely, it was intended to establish cortical responses to the trueness of a statement irrespective of the particular constituent words and letters or sounds of the words. As unconditioned stimulus short aversive stimuli consisting of 1-ms electrical pulses were used. True and false statements were presented acoustically and only the true statements were immediately followed by electrical stimuli. 15 healthy participants and one locked-in ALS patient underwent the experiment. Three different classifiers were employed in order to differentiate between the two cortical responses by means of electroencephalographic recordings. The offline analysis revealed that semantic classical conditioning can be applied successfully to enable basic communication using a non-muscular channel.
PRISMATIC TOROIDAL LENS AND TRAFFIC SIGNAL LIGHT USING THIS LENS

A traffic signal light (10) comprises an array (11) of light-emitting diodes (12) for producing respective light rays, and an array (21) of lenses (22) for propagating light rays from the light-emitting diodes (12) toward a plurality of predetermined, distinct spatial points. The lenses (22) are each associated with a corresponding one of the light-emitting diodes (12), and each lens (22) comprises a solid body of light-propagating material defining a light-refracting surface (26) through which the light rays from the corresponding light-emitting diode (12) propagate. The light-refracting surface (26) is divided into distinct light-refracting surface (26) sections each associated to a corresponding one of the spatial points. The light-refracting surface (26) sections have diffferent configurations in view of deviating the light rays propagating therethrough toward the associated spatial points, respectively. Therefore, at each spatial point add the light rays deviated by the associated light-refracting surface sections of the different lenses.
Tc-99m SPECT Sestamibi for the Measurement of Infarct Size

There are a variety of approaches to assess the efficacy of reperfusion therapy, and myocardial protection, in acute myocardial infarction. This review summarizes the available evidence validating the use of technetium-99m sestamibi single-photon emission computed tomography (SPECT) for this purpose. Multiple lines of evidence have validated its clinical utility. SPECT sestamibi infarct size has been used as an endpoint in multiple randomized clinical trials. A smaller number of clinical trials have used both early and later imaging with SPECT sestamibi to assess myocardium at risk and myocardial salvage. SPECT sestamibi has a number of limitations which must be recognized. Nevertheless, SPECT sestamibi infarct size is a well-validated measurement with a long track record of performance as an endpoint in multicenter, randomized clinical trials.
Contributo al capitale circolante per "MTD" MARIUSZ Dziura SPÓŁKA JAWNA

Il progetto riguarda il sostegno dell'imprenditore nel fornire liquidità finanziaria e il sostegno alle attività in corso a causa delle difficoltà finanziarie incontrate dall'imprenditore a causa dell'epidemia di COVID-19. Assistenza finanziaria erogata nell'ambito del programma n. SA.57015 (2020/N)