SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
U-Pb geochronology and coupled Hf-Nd-Sr isotopic-chemical constraints of the Cassiterita Orthogneiss (2.47–2.41-Ga) in the Mineiro belt, São Francisco craton: Geodynamic fingerprints beyond the Archean-Paleoproterozoic Transition

Abstract The Cassiterita Orthogneiss is the oldest pluton so far found within the Mineiro belt. In situ zircon U-Pb ages constrain the crystallization of the Cassiterita Orthogneiss to between 2472 ± 11 and 2414 ± 29 Ma. Zircon overgrowths are dated at 2024 ± 54 Ma, which matches the timing of the regional metamorphic overprint in the main belt. One metatonalite dike yields a zircon U-Pb age of 2156 ± 17 Ma, while a single inherited core is concordant at 2426 ± 17 Ma. The studied rocks exhibit low to medium grade metamorphism, and show tonalitic and granodioritic composition akin to TTG suites (tonalite-trondhjemite-granodiorite). The trace element patterns suggest that partial melting and fractional crystallization operated in the genesis. The La/Yb N , Yb N , Sr/Y, Nb/Ta and Zr/Sm values point to a garnet amphibolite residue. The positive e Nd(t) (+5.2 to +1.3) and low 87 Sr/ 86 Sr i (0.700–0.702) isotopic signatures suggest a LREE- and/or LILE LILE-enriched MORB mantle source. The zircon e Hf(t) parameters (-8.0 to +2.9) of the studied samples indicate some crustal assimilation during magma genesis. The chemical and isotopic signatures of the Cassiterita Orthogneiss are similar to nearby (ca. 2.35 Ga) TTG plutons, interpreted as cogenetic. This peculiar plutonism (from 2.47 to 2.35 Ga) marks the earliest stage of a long-lived accretionary regime (2.47–2.00 Ga) that built the Mineiro belt. This earliest orogenic event is roughly coeval with the (chemical) sedimentary infill of the passive basin (Minas Supergroup), previously dated at ca. 2.42 Ga. The age matches suggest a geodynamic link between the oceanic arc magmatism and penecontemporaneous basin infill in the continental margin. Early Paleoproterozoic TTG plutons such as the Cassiterita Orthogneiss have been related to the earliest accretionary processes that developed away from continental margins, where roughly coeval dike swarms and A-type plutons are emplaced along with the onset of passive basins. We explore the potential association and temporal interplay between convergent and intraplate settings and other major changes beyond the Archean-Paleoproterozoic Transition.
Flexible energy production, demand and storage-based virtual power plants for electricity markets and resilient dso operation

FEVER will implement and demonstrate solutions and services that leverage flexibility towards offering electricity grid services that address problems of the distribution grid, thus enabling it to function in a secure and resilient manner. The project encompasses technologies and techniques for extraction of energy flexibilities from virtual and explicit energy storage (batteries, V2G) and demand response. FEVER will leverage the potential for flexibility due to the electrification of sectors such as heating (heat pumps, district heating) and cooling (e.g. industrial refrigeration). In FEVER we will implement a comprehensive flexibility aggregation, management and trading solution that incorporates intelligence around the optimal flexibility orchestration and is capable to offer flexibility services in different markets (local, wholesale). In addition, a peer-to-peer flexibility trading toolbox will be implemented with a distributed ledger technology enabling autonomous peer-to-peer trading. FEVER will implement a set of goal-oriented applications and tools that empower DSOs with optimal grid observability and controllability. The DSO toolbox will include advanced monitoring and automated control functions (critical event prevention, self-healing, island-mode power management, etc.). FEVER will carry out extensive demonstration and testing activities in multiple settings. For scalability assessment the project includes large scale simulations of novel market mechanisms for day-ahead and continuous trading of flexibility services, and simulations of wholesale-retail market coupling.These simulations will contribute to the quantification of the impact of flexibility services at the distribution grid level and beyond (transmission level). FEVER’s holistic approach to flexibility will facilitate establishing and operating appropriate business models for all players in the market, thereby providing the EU with a secure, efficient and resilient electric grid.
Quality Circulation of the goods on the premises of the logistics station of the program

This project studies the structure and operation of a Cross-Boarding Area Management Platform (CAMP) that can function as a Logistics Single Window for an integrated and paperless logistics chain. CAMP integrates a network of interoperable platforms at the service of shippers and logistics chain actors. The selected supply chains share the one-stop-shop concept. It involves customers and suppliers to create a credible tool for SMEs to globalise products in a cross-border way and make transport more competitive. The area in question involves secondary and tertiary nodes, for a closer relationship with the primary cluster (port nodes and inland transport routes of people and goods). While capitalising on the results of previous projects, this research study will enhance the appeal of nodes by quantifying the reduced total transport chain time economically.  The architecture is designed to maximise adaptability, flexibility and scalability to support modal balance and communications between different size businesses and Authorities (and between Authorities) with different computer and service capabilities.   For future IT implementations, this project aims to define the logical system and metadata needed to operate a platform by surveying the needs of businesses. CIRCUMVECTIO for freight transport and NECTEMUS for passengers intend to deal with critical cross-border area issues, due to the mixed demand for maritime traffic between the continent and the islands.
ARTIFICIAL LIFT TOOL

The present invention relates to an artificial lift tool for being introduced in a wellbore or a casing and submerged in well fluid. The artificial lift tool extends in a longitudinal direction from a top end adapted to be connected to a wireline to a bottom end. The tool comprises a motor unit and a pump unit. Furthermore, invention relates to a production well wherein the artificial lift tool is submerged in a well fluid; to the use of the artificial lift tool for providing artificial lift in a well; and to a method for providing artificial lift in a well.
Lógica, formação escolar e filosofia entre os jesuítas

Lógica, formação escolar e filosofia entre os jesuítas Resumo: O interesse mais direto deste artigo é a relação entre a Lógica e a formação filosófica na educação jesuíta. Para compor uma imagem da importância e da concreção da Lógica na formação proposta pelos inacianos, nós nos concentraremos na Ratio Studiorum e na obra do jesuíta português Pedro da Fonseca (1526-1599). A razão do recorte proposto é que as reflexões de Fonseca sobre o tema parecem, por um lado, orientar outros jesuítas, como é o caso de Sebastião do Couto, que é o autor da dialética do Curso Conimbricense; por outro, elas são mais completas, sobretudo pela atenção dada por Fonseca ao método e às disputationes. De posse do conceito de Lógica de Fonseca, concluímos com a indicação de caminhos contemporâneos de revisitação de lógicas do passado. Palavras-chave: lógica; método; educação; jesuítas. Logic, school education and philosophy among the Jesuits Abstract: The most direct interest of this article is the relationship between Logic and philosophical formation in Jesuit education. In order to produce an image of the importance and concretion of Logic in the formation proposed by the Ignatians, we will focus on the Ratio Studiorum and on the work of the Portuguese Jesuit Pedro da Fonseca (1526-1599). The reason for the proposed approach is that Fonseca's reflections on the subject seem, on the one hand, to guide other Jesuits, such as Sebastião do Couto, who is the author of the dialectic of Curso Conimbricense; on the other hand, Fonseca’s conception of logic is more complete regarding the other Jesuits, especially due to the attention given by our author to the method and the disputationes. In possession of Fonseca's Logic concept, we conclude with an indication of contemporary paths for revisiting the logics of the past. Key-words: logic; method; education; Jesuits. Logica, educazione scolastica e filosofia tra i gesuiti Abstract: L’interesse più diretto di questo articolo è il rapporto tra Logica e la formazione filosofica nell’educazione dei gesuiti. Per produrre un’immagine dell’importanza e della concretezza della Logica nella formazione proposta dagli inaziani, ci concentreremo nella Ratio Studiorum e nell’opera del gesuita portoghese Pedro da Fonseca (1526-1599). Il motivo di questa scelta è che le riflessioni di Fonseca sull’argomento sembrano, da un lato, guidare gli altri gesuiti, come Sebastião do Couto, cioè, l’autore della dialettica del Curso Conimbricense; da l’altro, la concezione di logica di Fonseca è più completa riguardo ad’altri gesuiti, soprattutto per l’attenzione data dall’autore al metodo e alle disputationes. Possedendo il concetto di logica di Fonseca, concludiamo con l’indicazione di modi contemporanei di rivisitare le logiche del passato. Parole chiave: logica ; metodo ; educazione ; gesuiti. Data de registro: 16/09/2021 Data de aceite: 01/12/2021
A fully integrated, animal-free, end-to-end modelling approach to oral drug product development

Oral drug products are preferred by hundreds of millions of patients in Europe. Yet, the challenges around formulating drugs for oral administration have increased tremendously over the last 30 years, mainly because most drugs coming through the Pharma pipeline are too poorly soluble to be efficiently absorbed from the GI tract. A quantum leap in identifying the optimal formulation for a new drug in the most efficient way possible is urgently needed to keep the Pharma industry in Europe competitive. Further, due to the enormous challenges in formulating poorly soluble drugs for oral administration, the numbers of animals used to screen formulation prototypes are increasing, despite EU commitment to reducing animals in research. The InPharma Consortium provides a unique solution to solving these important challenges.

The InPharma EID will strengthen Europe’s innovation capacity and leadership in the Pharma sector, specifically in drug formulation. Exceptional intersectoral training will be provided to 13 ESRs through pioneering research focused on harnessing computational pharmaceutics, Biorelevant in vitro testing and PBPK modeling, generating an integrated, end-to-end, animal-free approach to formulating poorly soluble drugs for oral administration. ESRs will undergo specialized training program to build proficiency in essential research and industry disciplines, while training in professional skills and entrepreneurship will prepare them to become trailblazers in pharmaceutical formulation.

A highlight of InPharma is the proven, successful collaboration among Consortium experts in the design, evaluation and implementation of enabling formulations for oral delivery. This EID will immerse ESRs in highly dynamic industrial environments under the supervision of leading academics, exposing them to all elements of pharmaceutical formulation, fostering collaboration, catalyzing synergies across the network and ultimately creating a truly unique training experience.
Electronic device with bent display and method for controlling thereof

A electronic device and a display method thereof are provided. A control method of the electronic device includes: detecting a touch input on an auxiliary display area; in response to a touch input being detected on a first area of the auxiliary display area in a and the electronic being in a state in which the electronic is gripped by a user, processing the touch input as a user input; and, in response to the touch input being detected on a second area of the auxiliary display area different from the first area and the electronic being in the state in which the electronic is gripped by the user, disregarding the touch input.
Ongoing Cerebral Vasculitis During Treatment of Rocky Mountain Spotted Fever

Rocky Mountain spotted fever is a tickborne infection that produces a systemic small-vessel vasculitis; its prognosis is excellent if appropriate treatment is initiated early. Because the advent of effective antirickettsial therapies predates the widespread use of brain magnetic resonance imaging, there are limited data on the effect of untreated Rocky Mountain spotted fever infection on neuroimaging studies.We describe a 7-year-old girl with delayed treatment of Rocky Mountain spotted fever who suffered severe neurological impairment. Serial brain magnetic resonance images revealed a progressive "starry sky appearance," which is proposed to result from the same small vessel vasculitis that causes the characteristic skin rash of this infection.Neurological injury can continue to occur despite specific antirickettsial therapy in Rocky Mountain spotted fever. This child's clinical features raise questions about the optimal management of this infection, particularly the utility of immune modulating therapies in cases of delayed treatment and neurological involvement.
Research on progresses and directions of location model in ubiquitous computing

Location model plays an important role in ubiquitous computing and the Internet of Things,which can help to implement the fusion of physical world and information world.An overview of location models is provided.It focuses on several aspects,including basic principles and approaches of location model,location reasoning,location representation methods, ontology-based models,and geospatial ontology.Especially the most popular ontology-based location models are compared and contrasted.A number of location models are developed specifically for use in pervasive computing,none of which appears to cover adequately unified concept model,rich location logics,powerful reasoning capability.A multidisciplinary intersection approach to researching location model,combining location theory,ontology theory,and geospatial theory,is pointed out in order to obtain a unified location model with powerful reasoning ability.
O governo da justiça na Guiana Francesa sob ocupação portuguesa (1809-1817)

Resumo A historiografia recente sobre as práticas administrativas na América portuguesa tem-se consagrado às instituições e aos agentes responsáveis pela aplicação da justiça nas diversas regiões e capitanias, sem, entretanto, ter abordado um território conquistado pelos portugueses no início do século XIX. A proposta deste artigo é a análise da administração da justiça na Guiana Francesa entre os anos de 1809 e 1817, época em que o território esteve sob ocupação portuguesa. Considerada por Dom João VI como parte de seus “Estados”, a Guiana foi governada por dois agentes portugueses sob dependência da capitania do Grão-Pará. A partir da comparação entre as estruturas jurídicas coloniais francesa e portuguesa, buscou-se analisar as adaptações empreendidas pelos portugueses para o bom governo da justiça na Guiana, pois, como ficou estipulado pela capitulação, o Código Civil francês continuou em vigor na colônia. O artigo evidencia, ainda, o papel desempenhado por João Severiano Maciel da Costa como intendente da Guiana. O estudo utiliza documentos conservados no Arquivo Nacional do Rio de Janeiro (AN), na Biblioteca Nacional (BN), no Arquivo Histórico do Itamaraty (AHI), no Arquivo Ultramarino Francês (ANOM) e no Arquivo Departamental da Guiana (ADG).
Effects of the major sudden stratospheric warming event of 2009 on the subionospheric very low frequency/low frequency radio signals

This paper presents effects of the major Sudden Stratospheric Warming (SSW) event of 2009 on the sub-ionospheric Very Low Frequency/Low frequency (VLF/LF) radio signals propagating in the earth-ionosphere waveguide. Signal amplitudes from four transmitters received by VLF/LF radio networks of Germany and Japan corresponding to the major SSW event are investigated for possible anomalies and atmospheric influence on the high to mid-latitude ionosphere. Significant anomalous increase or decrease of nighttime and daytime amplitudes of VLF/LF signals by ∼3-5 dB during the SSW event have been found for all propagation paths associated with stratospheric temperature rise at 10 hPa level. Increase or decrease in VLF/LF amplitudes during daytime and nighttime is actually due to the modification of the lower ionospheric boundary conditions in terms of electron density and electron-neutral collision frequency profiles and associated modal interference effects between the different propagating waveguide modes during the SSW period. TIMED/SABER mission data are also used to investigate the upper mesospheric conditions over the VLF/LF propagation path during the same time period. We observe a decrease in neutral temperature and an increase in pressure at the height of 75-80 km around the peak time of the event. VLF/LF anomalies are correlated and in phase with the stratospheric temperature and mesospheric pressure variation, while minimum of mesospehric cooling shows a 2-3 day delay with maximum VLF/LF anomalies. Simulations of VLF/LF diurnal variation are performed using the well known Long Wave Propagating Capability (LWPC) code within the earth-ionosphere waveguide to explain the VLF/LF anomalies qualitatively.
Training research pioneers by utilizing and validating the promise of electroporation for minimal invasive oncological treatments.

The ElectroPros action aims to optimally prepare young researchers for the evolving technology in the healthcare space, especially related to minimal invasive oncology therapies, by offering a unique set of targeted interdisciplinary training and research assignments in the areas of biophysics modelling and simulation, device physics, optimization algorithms, software integration and experimental validation. Four European Industrial Doctorate positions are offered to Early Stage Researchers (ESRs) for a period of three years. In the training program a combination of industrial, academic and clinical research environments are provided by Philips, the University Clinic Aachen and RWTH Aachen, to explore the field of electroporation, as a new and promising technique for minimal invasive oncology treatment. 
Based on sound career development plans, and coached by experienced supervisors, the four ESRs involved will develop a competence profile which will springboard their future career in the wide European medical community in the industrial, clinical and academic domain. These researchers have the potential to become pioneers for new minimally-invasive therapies for the oncology domain.
During their training, the ESRs will work on electroporation based treatment of cancer. The ESRs address shortcomings of the currently available equipment to enable for the first time ever a reliable patient-specific electroporation based treatment for cancer. With a focus on liver cancer, the ESRs will collectively establish novel insights on the biophysical effects on various tissues, important to understand the treatment effect, and integrate this knowledge in optimal device (needle) design and multi-physics models for treatment outcome prediction and inverse planning algorithms. Furthermore, the developed assets will be integrated in clinical prototype software to support and optimize the clinical workflow.
An integrated computational and experimental approach to rapid synthesis of highly selective dual-targeted hdac/ck2, mmp2/ck2 inhibitors

Traditional drug design strategy based on a single target has serious difficulties in developing new therapies for diseases such as cancer.
Cancer is a very complex multi-genetic disease that involves multiple crosstalks between signaling networks. The use of cocktails of various anticancer agents interfering with different mechanisms has been the standard treatment to prevent the problems of resistance.
An alternative approach is to design multi-target modulators, directed to different disease mechanisms. That is the approach we have chosen for this project, where we seek to design, synthesize and evaluate new dual agents based on the inhibition of three enzymes involved in the development and progression of tumor processes: HDAC1, CK2 and MMP2.
CK2 is a serine / threonine kinase that is constitutively active and essential for cell viability. Its proliferative and anti-apoptotic properties create a favorable cellular environment for tumor progression and maintenance and, therefore, constitutes an interesting target for the treatment of cancer.
Acetylation/deacetylation of histones is one of the epigenetic mechanisms that regulates gene expression. HDACs (histone deacetylases) remove acetyl groups from histones, inducing condensation of chromatin and, therefore, the repression of gene transcription. For this reason, they are considered key targets to reverse aberrant epigenetic changes associated with cancer.
Matrix metalloproteinases (MMPs), also called matrixins are another family of Zn-dependent enzymes. Our research group has extensive experience in the design and synthesis of inhibitors of MMP2 provided with high activity and, more importantly, high selectivity over other metalloproteinases. The design of multi-target modulators will be carried out making use of computational techniques and based on the previous experience of the group in the design and synthesis of inhibitors of these three targets through a fragment based process.
Signs and stability in higher-derivative gravity

Perturbatively renormalizable higher-derivative gravity in four space–time dimensions with arbitrary signs of couplings has been considered. Systematic analysis of the action with arbitrary signs of couplings in Lorentzian flat space–time for no-tachyons, fixes the signs. Feynman [Formula: see text] prescription for these signs further grants necessary convergence in path-integral, suppressing the field modes with large action. This also leads to a sensible wick rotation where quantum computation can be performed. Running couplings for these sign of parameters make the massive tensor ghost innocuous leading to a stable and ghost-free renormalizable theory in four space–time dimensions. The theory has a transition point arising from renormalization group (RG) equations, where the coefficient of [Formula: see text] diverges without affecting the perturbative quantum field theory (QFT). Redefining this coefficient gives a better handle over the theory around the transition point. The flow equations push the flow of parameters across the transition point. The flow beyond the transition point is analyzed using the one-loop RG equations which shows that the regime beyond the transition point has unphysical properties: there are tachyons, the path-integral loses positive definiteness, Newton’s constant [Formula: see text] becomes negative and large, and perturbative parameters become large. These shortcomings indicate a lack of completeness beyond the transition point and need of a nonperturbative treatment of the theory beyond the transition point.