SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
The burden of behavioral risk factors for cardiovascular disease in Europe. A significant prevention deficit

The study objective was to assess the burden of major cardiovascular disease (CVD) behavioral risk factors (BRFs) (i.e., smoking, excess body weight, physical inactivity, risky alcohol consumption) among individuals in the community with and without CVD history.For the current study, a subset of the data from the Survey of Health, Ageing and Retirement in Europe (SHARE) was analyzed, which were collected from 26,743 individuals aged 50+ years old, during the 1st wave of SHARE in 2004/05 in eleven European countries.Among those with CVD, there is a statistically significant higher percentage of inactive individuals (81.4% vs. 69.5 among those without CVD), and of individuals with excess body weight (64.3%) or obese (21.6%). Patients with CVD had a lower prevalence of smoking and risky alcohol consumption in most countries, whereas the prevalence of high body weight and physical inactivity was higher in CVD patients compared to individuals without CVD in almost all countries. More than half of the population has at least two BRFs, with a significantly higher prevalence of multiple BRFs among those diagnosed with CVD.Study findings suggest that a significant burden of behavioral risk factors for CVD remains in the population overall but also among patients diagnosed with CVD. Given the significant prevalence of BRFs, the prevention benefits would be immense for all stakeholders involved and negligence would be perilous.
SMART CHIAENZA

O OBJETIVO DA COMUNICAÇÃO É FACILITAR INVESTIMENTOS DESTINADOS A APOIAR A AQUISIÇÃO DE COMPETÊNCIAS POR EMPRESAS QUE PERMITAM O LANÇAMENTO E CONSOLIDAÇÃO DE UMA TRAJETÓRIA DE INOVAÇÃO, ATRAVÉS DE PROJETOS DE INVESTIMENTO EM PRODUTOS/SERVIÇOS, PROCESSOS, INOVAÇÃO ORGANIZACIONAL E COMERCIAL, TAMBÉM A SEREM IMPLEMENTADOS ATRAVÉS DE PROJETOS DE REDE, FINANCIAMENTO DOS CUSTOS DE PATENTES DE IDEIAS INOVADORAS, CUSTOS LIGADOS À PROTOTIPAGEM, CUSTOS RELACIONADOS COM O DESENVOLVIMENTO DE COMPETÊNCIAS DIGITAIS.
Restoring tissue regeneration in patients with visceral graft versus host disease.

Stem cell regenerative therapies hold great promise for patients suffering from a variety of disorders that are associated with tissue or organ injury. Regeneration relies on tissue or organ-specific stem and progenitor cells, but can also aim at promoting the endogenous repair capacity of the body. 

Mesenchymal stromal cells (MSC) are undergoing clinical testing in a variety of clinical conditions aiming at repair through direct or indirect mechanisms. Their ability to form bone or cartilage is used to directly repair these tissues. In other conditions their regenerative effects are based on endogenous repair through their anti-inflammatory properties. The latter mechanism is important in the treatment of acute Graft-versus-Host Disease (GvHD). We have been involved in the clinical development from the beginning and we have shown the therapeutic potential. However, no results of controlled randomized phase 3 studies have been published to date, thereby hampering safety and efficacy assessment. 

Within our consortium we have developed an academic infrastructure for the harmonized production of MSC. In the RETHRIM proposal this will be combined with our clinical expertise to conduct the first Europe-wide placebo controlled randomized phase III trial using MSC regenerative therapy for the treatment of steroid-resistant visceral GvHD. Central to the RETHRIM project is the clinical trial for which 150 patients will be recruited. All MSC products will be extensively analysed using molecular and functional markers, in order to develop a potency signature for the product and for the prediction of response. We also intend to collect data from additional quality of life, health technology assessment and ethical studies. We will apply for an Orphan Drug Designation in Europe and this may serve as a stepping-stone for the further commercialization of the MSC product, once a positive outcome has been obtained.
HEATED SUBSTRATE SUPPORT WITH TEMPERATURE PROFILE CONTROL

Methods and apparatus of substrate supports having temperature profile control are provided herein. In some embodiments, a substrate support includes: a plate having a substrate receiving surface and an opposite bottom surface; and a shaft having a first end comprising a shaft heater and a second end, wherein the first end is coupled to the bottom surface. Methods of making a substrate support having temperature profile control are also provided.
Graphic Swim: 2D and 3D Printing in Glass Casting

This document is a report on developing processes to encourage flow of the graphic image in kilnformed glass. It is also a description and reflection on a body of artworks in glass in which new visual qualities were exposed through a mishap and turned into an aesthetic choice. The research links 2D print approaches to 3D printing and their integration in cast glass. It updates the author’s practice-based PhD research, a study that utilizes glass printing, cutting and fusing processes to combine the printed image within the glass object. The outcomes of the study can be organized under two approaches that have been developed, one appropriate to practical workshop teaching, and the other for the conceptualization and fabrication of new personal artworks.
Enabling high-level application development for the Internet of Things

Application development in the Internet of Things (IoT) is challenging because it involves dealing with a wide range of related issues such as lack of separation of concerns, and lack of high-level of abstractions to address both the large scale and heterogeneity. Moreover, stakeholders involved in the application development have to address issues that can be attributed to different life-cycles phases. when developing applications. First, the application logic has to be analyzed and then separated into a set of distributed tasks for an underlying network. Then, the tasks have to be implemented for the specific hardware. Apart from handling these issues, they have to deal with other aspects of life-cycle such as changes in application requirements and deployed devices.Several approaches have been proposed in the closely related fields of wireless sensor network, ubiquitous and pervasive computing, and software engineering in general to address the above challenges. However, existing approaches only cover limited subsets of the above mentioned challenges when applied to the IoT. This paper proposes an integrated approach for addressing the above mentioned challenges. The main contributions of this paper are: (1) a development methodology that separates IoT application development into different concerns and provides a conceptual framework to develop an application, (2) a development framework that implements the development methodology to support actions of stakeholders. The development framework provides a set of modeling languages to specify each development concern and abstracts the scale and heterogeneity related complexity. It integrates code generation, task-mapping, and linking techniques to provide automation. Code generation supports the application development phase by producing a programming framework that allows stakeholders to focus on the application logic, while our mapping and linking techniques together support the deployment phase by producing device-specific code to result in a distributed system collaboratively hosted by individual devices. Our evaluation based on two realistic scenarios shows that the use of our approach improves the productivity of stakeholders involved in the application development.
Modulation of resting brain cerebral blood flow by the GABA B agonist, baclofen: A longitudinal perfusion fMRI study

Preclinical studies confirm that the GABA B agonist, baclofen blocks dopamine release in the reward-responsive ventral striatum (VS) and medial prefrontal cortex, and consequently, blocks drug motivated behavior. Its mechanism in humans is unknown. Here, we used continuous arterial spin labeled (CASL) perfusion fMRI to examine baclofen's effects on blood flow in the human brain.Twenty-one subjects (all smokers, 12 females) were randomized to receive either baclofen (80 mg/day; N=10) or placebo (N=11). A five minute quantitative perfusion fMRI resting baseline (RB) scan was acquired at two time points; prior to the dosing regimen (Time 1) and on the last day of 21 days of drug administration (Time 2). SPM2 was employed to compare changes in RB from Time 1 to 2.Baclofen diminished cerebral blood flow (CBF) in the VS and mOFC and increased it in the lateral OFC, a region involved in suppressing previously rewarded behavior. CBF in bilateral insula was also blunted by baclofen (T values ranged from -11.29 to 15.3 at p=0.001, 20 contiguous voxels). CBF at Time 2 was unchanged in placebo subjects. There were no differences between groups in side effects or cigarettes smoked per day (at either time point).Baclofen's modulatory actions on regions involved in motivated behavior in humans are reflected in the resting state and provide insight into the underlying mechanism behind its potential to block drug-motivated behavior, in preclinical studies, and its putative effectiveness as an anti-craving/anti-relapse agent in humans.
Babbler feasibility study in adjacent market segments.

Babbler is a next-generation seal for supply-chains. 

Supply-chain security is flawed and unchanged in 30 years. If you transport or store goods, it is difficult to know that your goods were treated correctly. For decades the supply chain industry has depended on bolt/cable seals, documentation and locks, knowing that these provide extremely limited safeguards and evidence trails. As a result theft, people trafficking and narcotics smuggling are rampant. An estimated 8% of medicine sold worldwide is counterfeit (Source: WHO 2015). Improper storage is detected too late to prevent waste. In addition, inspection delays are a major cost in the total supply chain.

Babbler uses IoT and an inverted evidence principle to provide much better assurance of cargo security problems. In 2015 we were selected for an accelerator in the EU FIWARE program and in that accelerator won a cash prize for best startup in 2016. The accelerator provided funding so we could create and test a solution for shipping containers with business partners (Royal FloraHolland, Dutch Customs Organisation, Seatrade and others). 

Although Babbler proved its value in those trials and is attracting international interest, the shipping industry is conservative and slow-moving. To use Babbler a number of links in the supply chain have to decide to work together, which makes the buying process slow. We concluded that we can grow faster by focussing on niches in the supply chain, rather than an entire chain itself. 

We have identified several candidate market segments but need funds to test our assumptions and determine if Babbler needs to be tweaked accordingly. We are considering:
 1. Transport and storage of medical supplies, 
2. TAPA level 2 certified road carriers, 
3. Road carriers that EU cross borders with people trafficking issues. 

Given the size of the markets we can create a €20-25 million business, with a high-tech labour force of 40-50 people.
Development and characterisation of new immunogenic gemms of lung cancer

Many studies have recently archived a remarkable clinical efficacy of immunotherapeutic treatments in several cancers including non-small cell lung cancer (NSCLC). However, these approaches are not always successful and it is currently impossible to predict a therapeutic response or serious adverse event. These fundamental issues need to be addressed and, to recapitulate the complexity of interactions between immune cells and cancer, this has to be done in vivo. However, genetically engineered mouse models (GEMMs) of NSCLC do not mirror the genomic instability and the high mutations rate of their human counterparts. Consequently, these tumours rarely present neo-antigens that can induce an immune response, and are considered poorly immunogenic. To our knowledge, a genetically defined model of an immunogenic spontaneous tumour does not exist. Here, we propose to develop such an immunogenic GEMM (iGEMM).
The leading mouse model of lung cancer is the GEMM Kraslsl-G12D/wtTrp53fl/fl (KP). We propose two strategies to induce either genomic instability or mutation rate in the KP model. 1) We will overexpress Mad2, a component of the mitotic spindle assembly checkpoint, to induce aneuploidy in KP tumours; 2) We will overexpress the cytidine deaminase Apobec3 to increase the mutation rate of KP tumours.
The resulting immunogenic GEMMs (iGEMMs) will be characterised and used to assess new therapies that trigger an immune response and to address mechanisms which drive immunotolerance. iGEMMs will facilitate the investigation of currently available immunotherapies which will help predict clinical response to these therapies and investigation on alternative strategies to treat resistant lung tumours. All together, these investigations will provide novel information regarding the best strategies to cure NSCLC by modulation of the IS.
Making Migration Work for Development - Policy tools for strategic planning in SEE regions and cities

The focus of the project is to enhance policy-making, reinforcing the capacity of public administrations to understand, anticipate and strategically manage the implications of demographic change for the growth and cohesion of European regions and cities, and for the overall integration of the SEE area. Local and regional authorities are at the forefront in facing the effects of current demographic, economic and social changes, and their mutual implications in terms of overall cohesion and competitiveness of their territories. They are confronted with the need to actively govern such processes, regaining their full planning and strategic capacity, instead of limiting their action to managing their ultimate effects. Demographic change is a complex process, that includes different trends of transformation in the population structure. The project MMWD is aware that migration flows have become the major force of population change, and that at the same time the knowledge gap is particularly evident when it comes to migration and, even more, to the effects migration flows produce on the economic and social development prospects for specific territories. MMWD takes into account the multifaceted realm of migration processes, which include movements occurring within the same region/country (i.e. from rural to urban areas) as well as across regions placed in different countries (i.e. intra-EU and between EU and non EU regions). MMWD will offer concrete knowledge-based tools to policy-makers and test policy-making processes that make appropriate use of such tools, at both sub-national and trans-national level - in policy areas that are clearly impacted by demographic changes, and particularly by migration, are are critical for sustainable growth and competiveness: labour market (to promote employment), human capital (to raise productivity and economic performance), and the local offer of social services (to ensure their sustainability).
Caracterización de Modelos Educativos de Universidades Chilenas: Configuración de sus Dimensiones Fundacionales

La demanda social por la reestructuración de la formación de profesionales para la sociedad del conocimiento impulsa la actualización de los Modelos Educativos (ME) de las Instituciones de Educación Superior (IES), cuya diversidad impide obtener una visión panorámica de las tendencias en Chile. En Chile las universidades estatales han experimentado políticas públicas como la del 80 que han promovido prácticas liberales en Educación Superior y la reducción del compromiso del Estado con ellas. Este estudio caracteriza los ME de las universidades tradicionales chilenas, identificando sus dimensiones fundacionales y su configuración. Se realiza un análisis de contenido con un nivel de profundización descriptivo e inferencial, mediante la revisión de una muestra representativa a nivel nacional de 15 ME de universidades tradicionales. Entre los resultados está la determinación de cinco dimensiones como un mapa de factores determinantes para la comprensión de cómo se aprende, se gestiona el currículum y qué recursos priorizan las IES. Si bien existen diferencias a nivel descriptivo entre universidades públicas y privadas, a nivel inferencial se constata su homogeneidad. En tanto que, se encuentran diferencias significativas según el año de aprobación de los modelos, evidenciando en los más recientes (después de 2016), un marcado énfasis por implementar dispositivos de rendición de cuentas, en desmedro de su vinculación territorial.
Microalgal Classification

Microalgae show enormous promise to simultaneously create industries aiming for remediation of wastewaters and producing value-adding coproducts for large nonsaturable markets, such as biofuels, biofertilizers, and biopolymers. To date, however, their commercially realized exploitation is restricted to a few strains for the production of fine chemicals, nutraceuticals, food additives, and as feed in aquaculture. Algal taxonomy has remained a mystery for applied phycologists. In this chapter, we aim to unriddle this puzzle by providing a brief overview of the difficulties of placing microalgae in a hierarchical, phylogenetically meaningful, classification scheme. The evolutionary origin of algal diversity is discussed, which explains why creating a phylogenetically meaningful classification scheme is fraught with difficulties. Finally, commercially used microalgae or those with demonstrated potential are described with a focus on their identifying characteristics. These described microalgae are then cross-linked to their remediation and bioproduct potential in the last two sections of this chapter.
CARBURIZED MONOTUNGSTEN AND DITUNGSTEN CARBIDE EUTECTIC PARTICLES, MATERIALS AND EARTH-BORING TOOLS INCLUDING SUCH PARTICLES, AND METHODS OF FORMING SUCH PARTICLES, MATERIALS, AND TOOLS

Earth-boring tools for drilling subterranean formations include a particle-matrix composite material comprising a plurality of at least partially carburized monotungsten carbide and ditungsten carbide eutectic particles dispersed throughout a matrix material. In some embodiments, the particles are at least substantially fully carburized monotungsten carbide and ditungsten carbide eutectic particles. In further embodiments, the particles are generally spherical or at least substantially spherical. Methods of forming such particles include exposing a plurality of monotungsten carbide and ditungsten carbide eutectic particles to a gas containing carbon. Methods of manufacturing such tools include providing a plurality of at least partially carburized monotungsten carbide and ditungsten carbide eutectic particles or at least substantially completely carburized monotungsten carbide and ditungsten carbide eutectic particles within a matrix material.
Water-To-Air backscatter communications

Over 70% of the Earth’s surface is covered by water, while the majority of the underwater areas are unexplored yet. Owing to growing underwater activities, e.g., undersea oil & gas exploration, and Internet of underwater things, reliable water-to-air wireless communications are urgently needed by the industry, military, and scientific communities. As it is difficult to use a single type of signal, e.g., acoustic, radio frequency (RF), or optical, for communication across a water-air interface, most existing water-to-air communications rely on sonobuoys to relay acoustic signals from underwater transmitters to RF receivers on/above the water surface. The global sonobuoy market is predicted to reach $595.9 million at a 6.62% CAGR over the period 2018-2023. Since sonobuoys might not be recovered from remote, hostile areas of the ocean, battery-powered sonobuoys (which have battery packs full of toxic metals) are posing a great threat to the marine environment. Although energy-harvesting technologies (e.g., photovoltaic, wave action, or seawater based semi-fuel cell) have been developed for sonobuoys to charge onboard energy storage systems, the challenge of miniaturizing and incorporating these technologies into the sonobuoy volume constraint remains a dominant issue. 
This project will develop novel water-to-air backscatter communication (WABCom) technology to enable the design of lightweight, battery-free sonobuoys by leveraging RF backscatter communications, where the RF energy harvested by the sonobuoy from an unmanned aerial vehicle’s (UAV) transmission is used to support the circuit operation at the sonobuoy, and the sonobuoy forwards the received underwater signal to the UAV via an RF backscatter link (i.e., by modulating the signal on the RF waveform reflected back to the UAV). Such miniature battery-free sonobuoys can be flexibly deployed (e.g., air-dropped by UAVs) where and when needed and are disposable with minimum impact on the marine environment.
SPIRO-LACTAM NMDA RECEPTOR MODULATORS AND USES THEREOF

Disclosed are compounds having enhanced potency in the modulation of NMDA receptor activity. Such compounds are contemplated for use in the treatment of conditions such as depression and related disorders. Orally available formulations and other pharmaceutically acceptable delivery forms of the compounds, including intravenous formulations, are also disclosed.
Underage alcohol policies across 50 California cities: an assessment of best practices

We pursue two primary goals in this article: (1) to test a methodology and develop a dataset on U.S. local-level alcohol policy ordinances, and (2) to evaluate the presence, comprehensiveness, and stringency of eight local alcohol policies in 50 diverse California cities in relationship to recommended best practices in both public health literature and governmental recommendations to reduce underage drinking.Following best practice recommendations from a wide array of authoritative sources, we selected eight local alcohol policy topics (e.g., conditional use permits, responsible beverage service training, social host ordinances, window/billboard advertising ordinances), and determined the presence or absence as well as the stringency (restrictiveness) and comprehensiveness (number of provisions) of each ordinance in each of the 50 cities in 2009. Following the alcohol policy literature, we created scores for each city on each type of ordinance and its associated components. We used these data to evaluate the extent to which recommendations for best practices to reduce underage alcohol use are being followed.(1) Compiling datasets of local-level alcohol policy laws and their comprehensiveness and stringency is achievable, even absent comprehensive, on-line, or other legal research tools. (2) We find that, with some exceptions, most of the 50 cities do not have high scores for presence, comprehensiveness, or stringency across the eight key policies. Critical policies such as responsible beverage service and deemed approved ordinances are uncommon, and, when present, they are generally neither comprehensive nor stringent. Even within policies that have higher adoption rates, central elements are missing across many or most cities' ordinances.This study demonstrates the viability of original legal data collection in the U.S. pertaining to local ordinances and of creating quantitative scores for each policy type to reflect comprehensiveness and stringency. Analysis of the resulting dataset reveals that, although the 50 cities have taken important steps to improve public health with regard to underage alcohol use and abuse, there is a great deal more that needs to be done to bring these cities into compliance with best practice recommendations.