SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Photocatalytic materials for cartridge and microchannel flow reactors

During the research of the ERC-funded project UNBICAT (ERC-CoG, contract number 647550), the Principal Investigator, and his research group have developed new photocatalysts and their application in different organic transformations. A recent development of the project has been the preparation of new photocatalysts and their immobilization onto different materials, making them heterogeneous catalysts. These heterogeneous photocatalysts are able to produce chemicals and products of interest to the chemical industry. Therefore, the heterogeneous photocatalysts developed in this project are expected to become valuable tools for the production of chemicals under more sustainable and milder conditions. The aim of the present Proof of Concept (PoC) project is to study their implementation in cartridges and microchannel reactors for flow chemistry. For this purpose, reaction optimization to scale-up the current mg-scale synthesis of the heterogeneous photocatalysts, and their incorporation onto cartridges and microchannel reactors will be carried out. In addition, the photocatalytic performance of the devices in the preparation of chemicals and products of interest to the industry will be validated using flow chemistry. This PoC project will also contain an analysis of the intellectual property and patent filing procedure required to protect the inventions within the field of synthesis and application of the catalyst. Additionally, a market analysis to identify potential industrial partners will be conducted. These photocatalytic cartridges and microchannel reactors will be valuable tools in different fields of the chemical industry for manufacturing chemicals, but also in academia for the preparation of products and to address other novel transformations.
Cancer cell-derived lymphotoxin mediates reciprocal tumour-stromal interactions in human ovarian cancer by inducing CXCL11 in fibroblasts

We have investigated the role of cytokine lymphotoxin in tumour-stromal interactions in human ovarian cancer. We found that lymphotoxin overexpression is commonly shared by the cancer cells of various ovarian cancer subtypes, and lymphotoxin-beta receptor (LTBR) is expressed ubiquitously in both the cancer cells and cancer-associated fibroblasts (CAFs). In monoculture, we showed that ovarian cancer cells are not the major lymphotoxin-responsive cells. On the other hand, our co-culture studies demonstrated that the cancer cell-derived lymphotoxin induces chemokine expression in stromal fibroblasts through LTBR-NF-κB signalling. Amongst the chemokines being produced, we found that fibroblast-secreted CXCL11 promotes proliferation and migration of ovarian cancer cells via the chemokine receptor CXCR3. CXCL11 is highly expressed in CAFs in ovarian cancer biopsies, while CXCR3 is found in malignant cells in primary ovarian tumours. Additionally, the overexpression of CXCR3 is significantly associated with the tumour grade and lymph node metastasis of ovarian cancer, further supporting the role of CXCR3, which interacts with CXCL11, in promoting growth and metastasis of human ovarian cancer. Taken together, these results demonstrated that cancer-cell-derived lymphotoxin mediates reciprocal tumour-stromal interactions in human ovarian cancer by inducing CXCL11 in fibroblasts. Our findings suggest that lymphotoxin-LTBR and CXCL11-CXCR3 signalling represent therapeutic targets in ovarian cancer.
DYNAMIC NATIVE BINDING FOR MANAGED ASSEMBLIES

A method, apparatus, system, article of manufacture, and computer readable storage medium provides the ability to dynamically bind a native assembly from a managed assembly. A managed assembly (e.g., a dynamically linked library (DLL)) is obtained. In the managed assembly, native application program interface entry points are identified. For each of the entry points, intended platform(s) and associated correct native assembly(ies) are specified in the managed assembly. The managed assembly is deployed onto a computer. For example, the single collection of managed and native assemblies can be deployed to all targeted computers, which consist of varying platform environments. During runtime execution, the executing platform of the application is determined. Based on the executing platform, an intended platform is selected and the entry points are bound to the correct native assembly.
Decision support for the supply of ecosystem services under global change

Pressures on forest ecosystems are very likely to increase as a consequence of socioeconomic and demographic trends. A growing population will demand more products (e.g., wood) to be extracted from forest ecosystems. At the same time, these harvesting activities and their interactions with global change drivers will impact the sustainability of the supply of a wider range of non-provisioning services (e.g., wildfire protection, water, and biodiversity). The integrity of ecosystems must be safeguarded when developing harvesting activities, and yet this is further complicated by the occurrence of natural disturbances such as wildfires and droughts, etc. New decision support approaches are needed that can cope with this challenge. 

European and the American experiences with the development and application of decision support approaches for the provision of ecosystem services (ESs), offer a solid base for continued improvement in the efficiency and effectiveness of forest management in the context of global change (e.g., responding to changes in demographics, socioeconomics, and climatic conditions). This provided the rationale for a project that will help to strengthen research collaboration through active networking and staff exchange between 8 European organizations and 10 American organizations that are leaders in these fields. 

This project will build from the top-level multidisciplinary expertise (wildfire ecology and management, wildfire behaviour simulation, hydrology, process-based modelling, biodiversity, wildlife management, ecology, water services, operations research, management science, stakeholder engagement, forest ecosystem management planning methods, supply chain management methods and decision support systems) in these organizations to address the integration of operational, tactical and strategic forest ecosystem management planning levels and potentiate the supply of ecosystem services at various spatial and temporal scales.
New studies in global IT and business service outsourcing: 5th global scourcing workshop 2011, Courchevel, France, March 14-17, 2011, revised selected papers

This book contains 11 carefully revised and selected papers from the 5th Workshop on Global Sourcing, held in Courchevel, France, March 14-17, 2011. They have been gleaned from a vast empirical base brought together by leading researchers in information systems, strategic management, and operations. This volume is intended for use by students, academics, and practitioners interested in the outsourcing and offshoring of information technology and business processes. It offers a review of the key topics in outsourcing and offshoring, populated with practical frameworks that serve as a tool kit for students and managers. The topics discussed combine theoretical and practical insights, and they are extensively illustrated by case studies from client and vendor organizations. Last but not least, the book examines current and future trends in outsourcing and offshoring, paying particular attention to how innovation can be realized in global or outsourced software development environments.
Unraveling the complexity of fungal drug tolerance at multiple scales of biology

Mortality from invasive fungal infections approaches 50%, despite the use of available antifungal drugs. While bacterial studies have focused on drug resistance, the rare appearance of antifungal drug resistance does not explain these treatment failures. Antifungal tolerance is a poorly understood property that is expressed to different degrees in different non-resistant isolates, yet has not been measured routinely in the clinic or in most research studies. We do not know how tolerance differs between isolates, what biological mechanisms drive it, how it affects only some cells in a single isolate, or whether it can be inhibited to improve treatment outcomes. Recently, the Berman lab found that tolerance is an intrinsic property, in which some cells of a non-resistant isolate continue growing in the presence of the drug that has the potential to explain antifungal treatment failures. In parallel, the Ralser lab found that inhibitors of metabolic pathways affect the stress survival of some cells and the Berman lab found that these inhibitors can clear tolerance and convert an antifungal drug from fungistatic to fungicidal, thereby killing the cells and halting their adaptation. Together, we combine expertise in pathogenic fungi (Berman) and metabolic systems (Ralser) to reach fundamental understandings of tolerance across the range of its biological scales by: 1) capturing the diversity of tolerance in a genomic and proteomic data resource of >1000 isolates; 2) identifying metabolic pathways and molecular mechanisms that drive tolerance within isolates; and 3) probing processes and compounds that affect phenotypic heterogeneity between cells and suppress tolerance. By elucidating the mechanisms that drive tolerance and fungal single-cell diversity, we propose to render tolerance targetable, providing a paradigm shift in anti-fungal treatment strategies.
THE INTERPLANETARY NETWORK SUPPLEMENT TO THE BURST AND TRANSIENT SOURCE EXPERIMENT 5B CATALOG OF COSMIC GAMMA-RAY BURSTS

We present Interplanetary Network localization information for 343 gamma-ray bursts observed by the Burst and Transient Source Experiment (BATSE) between the end of the 4th BATSE catalog and the end of the Compton Gamma-Ray Observatory (CGRO) mission, obtained by analyzing the arrival times of these bursts at the Ulysses, Near Earth Asteroid Rendezvous (NEAR), and CGRO spacecraft. For any given burst observed by CGRO and one other spacecraft, arrival time analysis (or 'triangulation') results in an annulus of possible arrival directions whose half-width varies between 11 arcsec and 21{sup 0}, depending on the intensity, time history, and arrival direction of the burst, as well as the distance between the spacecraft. This annulus generally intersects the BATSE error circle, resulting in an average reduction of the area of a factor of 20. When all three spacecraft observe a burst, the result is an error box whose area varies between 1 and 48,000 arcmin{sup 2}, resulting in an average reduction of the BATSE error circle area of a factor of 87.
Nanotextured surfaces for membranes, protective textiles, friction pads and abrasive materials

Cellulose, the most abundant polymer on Earth, is a classic example of a high reinforcement materials produced from renewable resources. Cellulose nanomaterials produced either with chemical and/or mechanical means from cellulose fibres are safe, biodegradable, ultra-strong, durable and suitable for novel functional applications. Cellulose nanomaterials strengthen the production of lean added value products. They enable novel functional products and improve the competitiveness of European industry. However, it is necessary to further develop application processes for cellulose nanomaterials. 

NanoTextSurf aims to upgrade existing pilot lines for manufacturing and demonstrating nanotextured surfaces with mechanically enhanced properties. The focal approach of the surface manufacturing concept is to construct nanostructured surfaces based on nanoscale biomaterials. Formation of surfaces will be realised by utilising these building blocks with on-line application techniques (cast and foam coating and screen-printing), which enable the formation of the true nanotextured architecture. This approach will guarantee that robust, efficient and easily up-scalable processes with in-line controlling methods will be available as open access services with reasonable costs. 

The nanotextured products and their mechanically enhanced performance will be demonstrated as value added products of the existing and novel bio-based membranes at liquid purification, functional textiles for fire retardant fabrics and linings, novel friction materials for transport applications and abrasive materials for surface finishing. Their economic feasibility, safety and environmental acceptability will be evaluated with life cycle sustainability assessment. The results can be exploited in the existing manufacturing lines. Besides these products, NanoTextSurf partners have recognised additional markets such as hospital textiles, industrial wipes, air purification filters and food packaging materials.
Multi-Stakeholder platform for a secure supply of refractory metals in europe

Refractory metals (tungsten, tantalum, rhenium, molybdenum and niobium) are highly strategic metals today mainly imported from a few countries. The European primary production remains below a few percentage. However, resources exist in Europe, as primary resources but mainly as secondary resources (industrial waste, urban mines). Valorizing these resources requires coordination and networking between researchers, entrepreneurs and public authorities to harmonise technologies, processes and services, develop standards, create new potential for export of eco-innovative solutions and for seizing new markets
MSP-REFRAM will address these challenges by creating of a common multi-stakeholder platform that will draw the current refractory metals value chains and identify its innovation potential in order to support the implementation of the EIP on Raw Materials. Coming from industry, research, public sectors and civil society, both Consortium Members and External Experts have joined forces with expertise covering the whole value chain including mining, processing, recycling, application.
The outputs of MSP-REFRAM will help Europe improve the supply value chain of refractory metals in the coming years, optimising the use of external resources as energy and water and at the same time reducing the amount and the toxicity of waste.
MSP-REFRAM will share its conclusions widely and efficiently, in a long lasting way thanks to the support of the PROMETIA association. To ensure the systemic change, the outcomes of the project will be made available to the stakeholders and to the public through different tools and reports.
In the medium term, MSP-REFRAM will contribute to better-informed decision-making at EU and national level as well as industry by proposing innovative value chains that will boost the refractory metals sector. In the longer term, this should improve the availability of these refractory metals, while creating greater added value to the economy and more jobs.
Magnetic field at geosynchronous orbit during high-speed stream-driven storms: Connections to the solar wind, the plasma sheet, and the outer electron radiation belt

[1] Superposed-epoch analysis is performed on magnetic field measurements from five GOES spacecraft in geosynchronous orbit during 63 high-speed stream-driven storms in 1995–2005. The field strength and the field stretching angle are examined as functions of time and local time, and these quantities are compared with the properties of the solar wind, the plasma sheet, and the outer electron radiation belt. Compression of the dayside magnetosphere coincides with an increased solar wind ram pressure commencing before the arrival of the corotating interaction region (CIR). Stretching of the nightside magnetosphere occurs in two phases: a strong-stretching phase early in the storm followed by a modest-stretching phase lasting for days. The strong-stretching phase coincides with the occurrence of the superdense plasma sheet, implying that ion pressure causes the strong stretching. This nightside strong-stretching perturbation corresponds to a ∼25% contribution to Dst*. The relativistic electron flux at geosynchronous orbit has a dropout recovery temporal profile that matches the strong-stretching temporal profile; however, the number density dropout and recovery of the electron radiation belt has a profile that leads the stretching profile. A comparison of geosynchronous field strengths and magnetopause field strengths indicates that magnetopause shadowing plays a role in the radiation belt dropout. Temporal fluctuations of the geosynchronous magnetic field are examined via 1 min changes of the GOES magnetic field vectors. Fluctuation amplitudes increase at all local times at storm onset and then slowly decay during the storms. The amplitude is linearly related to the Kp, PCI, and MBI indices, except during the strong-stretching phase of the storms.
FPGA-based reconfigurable processor for ultrafast interlaced ultrasound and photoacoustic imaging

In this paper, we report, to the best of our knowledge, a unique field-programmable gate array (FPGA)-based reconfigurable processor for real-time interlaced co-registered ultrasound and photoacoustic imaging and its application in imaging tumor dynamic response. The FPGA is used to control, acquire, store, delay-and-sum, and transfer the data for real-time co-registered imaging. The FPGA controls the ultrasound transmission and ultrasound and photoacoustic data acquisition process of a customized 16-channel module that contains all of the necessary analog and digital circuits. The 16-channel module is one of multiple modules plugged into a motherboard; their beamformed outputs are made available for a digital signal processor (DSP) to access using an external memory interface (EMIF). The FPGA performs a key role through ultrafast reconfiguration and adaptation of its structure to allow real-time switching between the two imaging modes, including transmission control, laser synchronization, internal memory structure, beamforming, and EMIF structure and memory size. It performs another role by parallel accessing of internal memories and multi-thread processing to reduce the transfer of data and the processing load on the DSP. Furthermore, because the laser will be pulsing even during ultrasound pulse-echo acquisition, the FPGA ensures that the laser pulses are far enough from the pulse-echo acquisitions by appropriate time-division multiplexing (TDM). A co-registered ultrasound and photoacoustic imaging system consisting of four FPGA modules (64-channels) is constructed, and its performance is demonstrated using phantom targets and in vivo mouse tumor models.
Magma-Assisted tectonics: two-phase dynamics of oceanic and continental rifts

There is widespread recognition of the central role of magma at divergent plate boundaries. However in almost all models, magmatism is treated as a by-product and is excluded from the dynamics. A thorough understanding of continental rifts and mid-ocean ridges, which are fundamental to plate tectonics, requires consistent models of magma intrusion into the lithosphere and crust. This is a proposal to develop models in which magmatism is an integral thermal, chemical, and mechanical component, and hence to better understand the basic functioning of plate tectonics.

Diverse insight and constraints on divergent boundaries come from decades of careful observation. But lacking adequate models of magmatism, old and new issues remain unresolved. For continents, a comparison of available tectonic force to inherent lithospheric strength indicates that magmatic intrusion is required to weaken plates sufficiently for rifting. For mid-ocean ridges, bathymetric analysis suggests that modest variation in the magma supply may be recorded by crustal emplacement and faulting. These phenomena cannot be understood and modelled in the context of single-phase flow. The proposed work breaks new ground in applying a theory that is innately two-phase; one where interpenetrating liquid and solid continua are governed by conservation of mass, momentum, and energy.

This theory will incorporate a viscoelastic-plastic/frictional rheology, modelling rock failure under tensile effective stress. Hence it will allow for dikes that interact consistently with faults. The open-source code will be validated by comparison with measurements of surface deformation/relief, products of seismic tomography, and geochemistry of lavas. In collaboration with distinguished project partners, models will be tailored to investigate the East African Rift System and Juan de Fuca ridge. Outreach will support mathematics in Africa. The proposed research will transform our understanding of magma-assisted tectonics.
FirSt and last Mile Inter-modal mobiLity in congested urban arEas of Adrion Region - PLUS

To become by 2050 world&#39;s first carbon-neutral continent, EU has pledged to reduce by 90% the GHG in transport by 2050, as confirmed in Dec. 2020 by European Commission&#39;s Sustainable and Smart Mobility Strategy.
To reduce by 55% the emissions by 2030, the Strategy calls also for the transition from a mobility system based on fossil energy consumption and private motorization to zero emission vehicles must be coherently pursued and accelerated, in a context in which walking, cycling, and use of collective means of transport (trains, buses, trams etc.) should be encouraged and favored.

Unfortunately, the COVID 19 pandemic has pushed people’s modal choice in a opposite direction; suddenly, the need for social distancing, one of the key measures to prevent viral infection from Covid-19, has given a new centrality to individual transport based on car.
As the circulating vehicles are largely still depending on fossil fuels (currently there are approx. only 4 million of e-vehicles on the EU roads, compared to EU target of 30 million by 2030), the social re-evaluation of the use of car increases gas emissions and air pollutants, in a context where the transport sector is responsible for approx. ¼ of the global greenhouse gas emissions in the atmosphere, whilst air pollutants cause yearly approx. 400.000 premature deaths in Europe, according to EEA reports, especially in densely inhabited areas.

Due to many different factors (circulation of obsolete transportation means; lack of sustainable mobility planning capacity; scarcity of data, e.g., on air quality in many IPA countries, as revealed by SMILE’s surveys), many ADRION regions/cities are hotspots for the above-described problems.

In such a context, SMILE PLUS intends to update and spread the main tool resulting from SMILE, namely the mobility scenarios as support to new transport policies in congested urban areas.

To ensure a good value for money relationship, the activities will be concentrated in 4 countries (Slovenia, Croatia, Serbia, and Italy) and will consist of:
1) Update the mobility scenarios, elaborated within SMILE, to ensure their resilience to the modal share determined by COVID-19 and the consequent revamp of fossil-powered private motorization.
2) Preparation of 1 video-tutorial to facilitate a diffuse use of mobility scenarios as tool to monitor and periodically update transport planning processes.
3) 1 meeting (online, in person or hybrid) per country, on:
- the use of post-Covid 19 mobility scenarios for transport planning set up by SMILE PLUS.
- the role of ETC to promote a sustainable mobility and increase cohesion.
4)  1 event per country to provide first-hand information on managing and implementing European projects to future beneficiaries (prioritizing entities not having experiences with EU projects), focused on green transition in mobility field, based on SMILE as case study.
MEDICAL APPLIANCE FOR EXTRACORPOREAL BLOOD TREATMENT

The medical appliance has lines (22, 23) that are connected to the vascular system of a patient. To ensure that an accidental escape of blood is identified, a camera (17) is provided and is directed at the extracorporeal circulation of the patient. The image signals from the camera (17) are processed in the sense that the colour of blood and/or its arrangement in the image area in the camera image is determined, wherein the size of the recorded image area with the colour of blood is also determined. In this way, an extracorporeal blood loss can be detected and signalled automatically.