SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Skin Autofluorescence, a Non-Invasive Marker for AGE Accumulation, Is Associated with the Degree of Atherosclerosis

Advanced glycation endproducts (AGEs) may be involved in the development of atherosclerosis, beyond diabetes and renal disease. Skin autofluorescence (AF) is a non-invasive marker for AGEs. We examined whether skin AF is increased in (subclinical) atherosclerosis and associated with the degree of atherosclerosis independent of diabetes and renal function.A cross-sectional study of 223 patients referred for primary (n = 163) or secondary (n = 60) prevention between 2006 and 2012 was performed. Skin AF was measured using the AGE-Reader. Ultrasonography was used to assess plaques in carotid and femoral arteries and computed tomography for the calculation of the coronary artery calcium score (CACS; in primary prevention only). Primary prevention patients were divided into a group with subclinical atherosclerosis defined as >1 plaque or CACS>100 (n = 67; age 53 year [interquartile range 48-56]; 49% male) and without (controls; 96; 43 [38-51]; 55%). Secondary prevention were patients with peripheral arterial disease (60; 64 [58-70]; 73%).Skin AF was higher in subclinical and clinical atherosclerosis compared with controls (skin AF 2.11 [interquartile range 1.83-2.46] and 2.71 [2.15-3.27] vs. 1.87 [1.68-2.12] respectively; P = 0.005 and <0.001). In a multivariate analysis, the association of skin AF with the atherosclerosis categories was independent of age, sex, diabetes, presence of the metabolic syndrome, Framingham Risk Score, and renal function. Skin AF correlated with most cardiovascular risk factors, Framingham risk score, and IMT and CACS.Skin AF is increased in documented subclinical and clinical atherosclerosis, independent of known risk factors such as diabetes and renal disease. These data suggest that AGEs may be associated with the burden of atherosclerosis and warrant a prospective study to investigate its clinical usability as a risk assessment tool for primary prevention.
futuro possível

Objetivo: o objetivo deste trabalho é gerar uma discussão sobre duas práticas de desenvolvimento acontecidas no Brasil e na Costa Rica durante os primeiros meses da pandemia da Covid-19. A reflexão é acompanhada de insumos teóricos das abordagens pós-desenvolvimentistas, com a finalidade de aportar novos elementos de análise que contribuam para o aprofundamento da crítica epistemológica e sociopolítica aos processos de apropriação da natureza pelo modo de produção capitalista na América Latina e suas implicações nos tempos da Covid-19. Metodologia: quanto ao delineamento metodológico, as práticas de desenvolvimento apresentadas foram construídas como estudos de caso, em função do estipulado pela pesquisa qualitativa, que sugere a importância da identificação dos atores envolvidos na expressão de um fenômeno, suas interações complexas e o mapeamento das narrativas e estratégias de sobrevivência e resistência que emergem como formas de superação dos conflitos. Resultados: a análise dos resultados propõe um giro ontológico na abordagem reflexiva do desenvolvimento que é coincidente com a adoção de olhares alternativos para entender as crises socioambientais originadas no Antropoceno. Com o propósito de debater as possibilidades de análise que oferecem os novos olhares epistêmicos e onto-políticos, as duas experiências empíricas permitem exemplificar a inadequação das categorias tradicionais para atender os cenários de contingência, sendo pertinente a incorporação de abordagens não centrados em medidas de controle, securitização e planejamento. Conclusões: as conclusões sugerem que o conjunto destas reflexões permite uma melhor compreensão sobre as formas em que ciência, política e natureza articulam-se nas sociedades contemporâneas. Este conhecimento é fundamental nos estudos sobre as práticas de legitimação da democracia, os projetos alternativos de cidadania e o surgimento de novas identidades territoriais.
REFLOW SOLDER FURNACE AND METHOD FOR REFLOW SOLDERING

A reflow soldering furnace and a method for reflow soldering of components (3) disposed on a circuit board (1) in a reflow soldering furnace is described, in which the temperature of the solder points (5) of the individual components (3) distributed over the circuit board (1) follows as precise a target temperature as possible during soldering operations in the soldering chamber (13), said target temperature being prescribed by a predefined solder-specific temperature cycle, wherein a heating device (17) is provided in the soldering chamber (13), said heating device heating the soldering chamber (13) to a predefined base temperature based on the predefined solder-specific temperature cycle prescribed for the soldering process during soldering operations, wherein an arrangement (19) of infrared heating elements (21) that are controllable independently of one another is disposed above the circuit board (1) in the soldering chamber (13) and covering the base surface of the soldering chamber (13), said arrangement being brought in by the circuit board (1) during soldering operations, and wherein a control system (27) is provided that operates the infrared heating elements (21) during soldering operation, said elements together with the heating device (17) effecting as homogeneous a heating of the solder points (5) distributed over the circuit board (1) as possible, said heating being to a target temperature predefined by the solder-specific temperature cycle, said target temperature being above the base temperature.
(16807.19102018.132000594) EMMAWHITE ONLINE

LE RECENTI ESPERIENZE SUI MERCATI ESTERI (CINA E VIETNAM) HANNO INDOTTO L?IMPRENDITRICE A RAFFORZARE LA PROPRIA PRESENZA A LIVELLO NAZIONALE: PER INSTAURARE COLLABORAZIONI CON PARTNER ESTERI QUALIFICATI ? NECESSARIO INFATTI PRESENTARSI CON UN?IMMAGINE E REPUTAZIONE CONSOLIDATA SUL TERRITORIO NAZIONALE. IL RAFFORZAMENTO DELLA PROPRIA PRESENZA FISICA SUL TERRITORIO ITALIANO/EUROPEO E DEL PROPRIO FATTURATO DOMESTICO ? INFATTI UN PRE-REQUISITO PER POTER DIALOGARE CON PLAYER QUALIFICATI SUI MERCATI ESTERI.PER RAGGIUNGERE QUESTO OBIETTIVO STRATEGICO, AS COMPANY HA DECISO DI AVVIARE 3 AZIONI:A) LANCIO NUOVA COLLEZIONE A MARCHIO PROPRIO EMMA WHITE: GARANTIRE CON CONTINUIT? L?IDEAZIONE E LA PRODUZIONE DI PRODOTTI A MARCHIO PROPRIO RAFFORZA LA CREDIBILIT? DELL?AZIENDA COME VERO OPERATORE MADE IN ITALY; INOLTRE, I MARGINI DERIVANTI DALL?ATTIVIT? CONTO TERZI SONO, DI SOLITO, RIDOTTI E, QUINDI, L?INVESTIMENTO SUL PROPRIO MARCHIO SIGNIFICA ANCHE AUMENTARE LA REDDITIVIT?. PER IL LANCIO DELLA COLLEZIO
Novel electric power-driven hydrodynamic injection system for gene delivery: safety and efficacy of human factor IX delivery in rats

The development of a safe and reproducible gene delivery system is an essential step toward the clinical application of the hydrodynamic gene delivery (HGD) method. For this purpose, we have developed a novel electric power-driven injection system called the HydroJector-EM, which can replicate various time-pressure curves preloaded into the computer program before injection. The assessment of the reproducibility and safety of gene delivery system in vitro and in vivo demonstrated the precise replication of intravascular time-pressure curves and the reproducibility of gene delivery efficiency. The highest level of luciferase expression (272 pg luciferase per mg of proteins) was achieved safely using the time-pressure curve, which reaches 30 mm Hg in 10 s among various curves tested. Using this curve, the sustained expression of a therapeutic level of human factor IX protein (>500 ng ml(-1)) was maintained for 2 months after the HGD of the pBS-HCRHP-FIXIA plasmid. Other than a transient increase in liver enzymes that recovered in a few days, no adverse events were seen in rats. These results confirm the effectiveness of the HydroJector-EM for reproducible gene delivery and demonstrate that long-term therapeutic gene expression can be achieved by automatic computer-controlled hydrodynamic injection that can be performed by anyone.
Analyzing exploration exploitation trade-off by means of P-I similarity index and dictyostelium based genetic algorithm

The optimal Exploration Exploitation Trade-off (EE Trade-off) is a fundamental goal in the field of Evolutionary Computation. To achieve the goal, we have proposed P-I similarity index and Dictyostelium based Genetic Algorithm (DGA). P-I similarity index provides an exploitation degree to enable applications to explicitly control EE Trade-off. DGA has specific operators which adopt the life cycle of dictyostelium to trade off between exploration and exploitation. In this study we specify the feature of P-I similarity index and introduce DGA with P-I similarity index. The computational experiments were carried out taking several combinatorial optimization problems as examples to suggest that DGA with P-I similarity index has wide applicability to discrete problems.
TREATMENT OF VAGINAL ATROPHY IN WOMEN WITH TUMOR PATHOLOGY RISK

The present invention relates to the use of estriol in the preparation of a pharmaceutical formulation for vaginal administration with the capacity to self-limit the absorption of estriol, for the prevention and/or the treatment of urogenital atrophy in women, said women having a high probability of developing an estrogen-dependent tumor or suffering or having suffered from an estrogen-dependent tumor.
The factor structure of posttraumatic stress disorder symptoms among Rwandans exposed to the 1994 genocide: A confirmatory factor analytic study using the PCL-C

The factor structure of posttraumatic stress disorder (PTSD) symptoms in Euro-American populations has been extensively studied, but confirmatory factor analytic studies from non-Western societies are lacking. Alternative models of DSM-IV symptoms were tested among Rwandan adults (N=465) who experienced trauma during the 1994 genocide. A cluster random survey was conducted with interviews held in Rwandan households. PTSD was assessed with the Posttraumatic Stress Disorder Checklist-Civilian version. Competing models were the DSM-IV, emotional numbing, dysphoria, aroused intrusion, and dysphoric arousal models. Results showed that the emotional numbing, dysphoria, and dysphoric arousal models had almost identical, good fit indices and fit the data significantly better than the other models. The emotional numbing and dysphoric arousal models also exhibited good construct validity. Results suggest that the latent structure of PTSD symptoms in Rwanda are comparable to that found in Euro-American samples, thereby lending further support to the cross-cultural validity of the construct.
Unilateral hearing during development: hemispheric specificity in plastic reorganizations

The present study investigates the hemispheric contributions of neuronal reorganization following early single-sided hearing (unilateral deafness). The experiments were performed on ten cats from our colony of deaf white cats. Two were identified in early hearing screening as unilaterally congenitally deaf. The remaining eight were bilaterally congenitally deaf, unilaterally implanted at different ages with a cochlear implant. Implanted animals were chronically stimulated using a single-channel portable signal processor for two to five months. Microelectrode recordings were performed at the primary auditory cortex under stimulation at the hearing and deaf ear with bilateral cochlear implants. Local field potentials (LFPs) were compared at the cortex ipsilateral and contralateral to the hearing ear. The focus of the study was on the morphology and the onset latency of the LFPs. With respect to morphology of LFPs, pronounced hemisphere-specific effects were observed. Morphology of amplitude-normalized LFPs for stimulation of the deaf and the hearing ear was similar for responses recorded at the same hemisphere. However, when comparisons were performed between the hemispheres, the morphology was more dissimilar even though the same ear was stimulated. This demonstrates hemispheric specificity of some cortical adaptations irrespective of the ear stimulated. The results suggest a specific adaptation process at the hemisphere ipsilateral to the hearing ear, involving specific (down-regulated inhibitory) mechanisms not found in the contralateral hemisphere. Finally, onset latencies revealed that the sensitive period for the cortex ipsilateral to the hearing ear is shorter than that for the contralateral cortex. Unilateral hearing experience leads to a functionally-asymmetric brain with different neuronal reorganizations and different sensitive periods involved.
Association Between Visceral and Subcutaneous Adipose Depots and Incident Cardiovascular Disease Risk Factors

Background— Visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) vary in volume and quality. We evaluated whether fat volume or attenuation (indirect measure of quality) predicts metabolic risk factor changes. Methods and Results— Framingham Heart Study Multi-detector Computed Tomography Substudy participants (n=1730, 45% women) were followed up over a mean of 6.2 years. Baseline VAT and SAT volume (in cm 3 ) and attenuation (in Hounsfield units) were assessed. Outcomes included blood pressure, lipids, and glucose. We constructed multivariable regression models predicting change from baseline to follow-up. Baseline VAT was associated with metabolic risk factors at follow-up. Per 500-cm 3 increase in baseline VAT, glucose was 2.34 mg/dL higher (95% confidence interval, 1.71–2.97) and high-density lipoprotein was 1.62 mg/dL lower (95% confidence interval, 0.97–2.28) in women ( P &lt;0.0001 for both). These findings remained significant after adjustment for body mass index. Results for SAT were similar although less striking. Lower (more negative) fat attenuation was associated with more adverse metabolic profiles at follow-up. For example, per 5-unit decrease in baseline VAT Hounsfield units, log triglycerides increased by 0.08 mg/dL (95% confidence interval, 0.05–0.12; P =0.005), which remained significant after adjustment for baseline VAT. Among men, VAT and SAT Hounsfield units were associated with changes in cardiovascular disease risk factors but were mostly attenuated after baseline volume adjustment. Conclusions— VAT volume and SAT volume are associated with incident metabolic risk factors beyond overall adiposity. Decreases in fat attenuation are also associated with incident risk factors. These findings suggest that both volume and quality of VAT and SAT contribute to metabolic risk.
Avaliação de Subsidência Planície Deltaica do Rio São Francisco a partir dos Vértices de Referência de Nível da Rede Altimétrica Brasileira

Os deltas são relevantes para a vida e o desenvolvimento econômico, social e ambiental de um país. Os deltas dos rios estão entre os ambientes mais vulneráveis à subsidência de terras. Processos de subsidência são caracterizados pelo movimento de uma porção da superfície da Terra, provocando um afundamento súbito ou recalque gradual do terreno. Os ambientes sedimentares deposicionais, como é o caso dos sistemas deltaicos, são propensos à subsidência devido à compactação de sedimentos. O delta do Rio São Francisco é uma planície arenosa do Quaternário construída em um baixo estrutural do Rio São Francisco na Bacia de Sergipe-Alagoas. A parte norte desta planície é composta por regiões constantemente inundadas. Trabalhos anteriores indicaram a existência de subsidência nesta região. Diversos estudos de subsidência de deltas têm sido realizados nas últimas décadas a partir da utilização de métodos geodésicos clássicos e tecnologias geoespaciais modernas. Este trabalho tem como objetivo avaliar a subsidência da planície deltaica do Rio São Francisco a partir dos vértices de referência de nível da Rede Altimétrica Brasileira. A subsidência de alguns trechos da superfície é apontada pelo decréscimo das altitudes dos vértices, onde detectou-se um rebaixamento nas imediações da sede do município de Piaçabuçu-AL. As constatações de rebaixamentos embasaram o projeto de uma Rede Geodésica para Monitoramento da Subsidência composta por 26 vértices geodésicos já materializados na planície deltaica. O rebaixamento pôde ser quantificado pelo desnível total no trecho 04-11 em AL-01 (-2,914 m) e o desnível total no trecho 20-11, em AL-02 (-5,433 m). Os resultados deste estudo servirão de referência para campanhas futuras de rastreio GNSS (Global Navigation Satellite System) e composição de um banco de dados de coordenadas geodésicas tridimensionais para monitoramento da subsidência no delta do São Francisco.
FURNITURE ARTICLE WITH CONCEALED STORAGE AND REMOVABLE PANELS

A modular furniture system composed from reconfigurable interlocking panels using corresponding slot and tab elements is disclosed. The ready-to-assemble furniture system includes a complementary arrangement of non-interlocking interior panels that become secured into position through the means of interlocking exterior side and end panels. The configuration of interlocking and non-interlocking panels hides the joinery formed by the slot and tab elements, and further utilizes selectively movable and/or detachable panels to conceal the contents of storage compartments.
Save Our Lives. A Comprehensive Road Safety Strategy for Central Europe


Every year more than 40,000 people lose their lives on Europe’s roads. In the EU, 1 out of every 5 child deaths due to injury are a result of road crashes. While many western European countries are making continuous progress in reducing the number of lives lost, fatality rates in many new Member States in the Central Europe Programme area remain high and in some they are even increasing. With the exception of Hungary all other new Member States in Central Europe have been confronted with a rise in the number of fatalities on their roads in 2007 (in the Czech Republic by 15% and in Ukraine even by 38%).

Central Europe clearly shows a higher number of road fatalities per million inhabitants than Western Europe. Within Central Europe, the highest value is observed in Poland (143 road fatalities per million inhabitants), followed by Slovenia (129), Hungary (128) and the Czech Republic (126)” compared to Italy (96), Austria (88), and Germany (62).

In Central Europe road safety challenge has reached a magnitude that even puts the overall competitiveness, the attractiveness as location for working and investments as well as the quality of life in the most seriously affected parts of the cooperation area at considerable risk. Road crashes have a severe negative impact on the social and economic situation in all countries, costing up to 2 percent or more of the GDP. Even though there are some good practice examples also in the new Member States of the Central Europe area, where road safety has been addressed successfully in the past years, severe joint efforts will be required by all relevant stakeholders on all levels to make a contribution also within Central Europe to reach the overall policy goal set by the European Commission (EC) in 2003 within the 3rd Road Safety Action Programme: to halve the number of lives lost on our roads from 50,000 to 25,000 per year by 2010.
Fatah e il processo di istituzionalizzazione: la lunga strada della Sesta Conferenza

The Fatah movement, the backbone of Palestinian national movement, faces a period of deep transformation. In the aftermath of Arafat’s death and with the decline of peace process, the movement has known a period of internal debate since 2005, in order to reshape the political space influenced by the emergence of Islamist challenge. This reform process follows two main directions: the internal reorganization and the political program. These topics constitute the base for the convening of the movement’s Sixth Conference, that could be read as the key factor for the transformation of Palestinian political system within an uncertain institutional framework, that of Palestinian National Authority. This work analyzes under which conditions Fatah movement is driving its transformation towards the institu- tionalization from a typical national liberation movement to a political party. Considering that the national aims have not been achieved yet, the Palestinian political landscape is shifting from a situation of one ruling party to a pluralistic de-facto situation, undoubtedly not the rule in the Arab world.
Introducing circular economy system to Alpine Space to achieve low-carbon targets

Cities and regions in Alpine Space have mainly set their low-carbon objectives and adopted relevant strategies in energy, mobility, construction etc. - however cross-sectoral approach is missing. The project GREENCYCLE aims to introduce the system of circular economy (replace linear) as a holistic approach to support implementation of low-carbon strategies and provide additional 2-4% greenhouse emission reduction to the partner cities. Circular economy deployment will save energy, water, recover critical raw materials, reduce transport, boost the eco-innovation, create green jobs and benefit to low income citizens, which is directly in line with priority 2 of the ASP. Cities as biggest emissions producers and biggest energy and materials consumers will play the pioneering role by developing circular economy implementation strategies where key target groups (utilities, SMEs, citizens, research organizations) will be actively involved in the process. Supporting toolbox will be developed as an e-tool which will enable planning, management and monitoring of circular economy processes and will be made publicly available. Important part of project is dedicated to pilot project implementation where partner cities will deploy circular economy approach in real-case scenarios to test and evaluate the toolbox. _x000D_
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In order to be effective, circular economy requires critical size of market and critical mass of materials which will be enabled by macro-regional approach. A transnational platform will be set up as a circular economy marketplace for materials and cooperation platform for further development of circular economy in Alpine Space. A platform will contribute to the lasting impact of the project with the active network membership of responsible local circular economy  managers. Partner cities will become a circular economy lighthouse role-models and will actively involve other Alpine Space cities and/or regions to follow.
ELECTRODE DEVICE

An electrode device 1 includes a first electrode 2, a second electrode 3, and an ion-conducting medium 7 extending over and in contact with the first electrode 2 and the second electrode 3. The ion-conducting medium 7 is made of a bicontinuous microemulsion including a water phase as a continuous phase and an oil phase as a continuous phase. At least one of the water phase and the oil phase is a gel.