SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Interregional Co-operation for Development of Innovative Regional Economic Clusters

In recent years proactive cluster management has become one of the standard tools of regional development. It is important for promoting technology-oriented economic development and for helping small and medium-sized companies to meet the challenges of global competition. However, approaches to cluster management differ widely and information gaps still exist in many regions. Overall objective / Objectif général “INNOFIRE - Interregional Co-operation for Development of Innovative Regional Economic Clusters” aims to improve and support existing local and regional cluster and networking initiatives through strategic interregional co-operation. Taking as an example regional clusters in the field of health business and medical technology, the partnership aims to exchange experience and transfer know-how on techniques and tools for effective cluster management. Expected results / Résultats attendus INNOFIRE leads to increased awareness of and knowledge on cluster management and support policies in the participating regions. Partners establish pro-active cluster start-up and management policies and improve the efficiency of existing support services. Activities include the analysis and benchmarking of existing policies and instruments as well as the development of new policies and tools for cluster management. Among others, partners develop the “MediMap” webtool, that supports the communication of available knowledge in the field of medical technologies and businesses as a supporting instrument.
Eu patient- centric clinical trial platform

EU-PEARL has the ambition of transforming the current approach of conducting single-compound clinical trials into the use of cross-company Integrated Research Platforms (IRPs), taking into consideration both patients’ interests and the opportunities from novel molecules for addressing medical needs. Patient-centric data and knowledge sharing have the potential to accelerate the development of new treatments and reduce the operational costs of clinical trials. EU-PEARL will improve clinical effectiveness, patients’ satisfaction and societal access to timely and affordable medicines and it will shape the clinical trials of the future. This will change the industry paradigm from competition to cooperation in four disease areas and provide the framework for designing IRPs in other disease areas.
The main objectives of EU-PEARL are: 
(1) To create a reusable, accessible and sustainable modular IRP for the design and execution of patient-centric, cross- company IRP in any disease area with unmet needs;  
(2) To set up the open, dynamic, patient inclusive IRP governance structure that will manage the appropriate regulatory, ethical, legal, statistical and data utilisation requirements of the IRP; 
(3) To disseminate and exploit the EU-PEARL paradigm through the provision of the necessary common tools, procedures, expertise and operational skills working to the highest scientific, regulatory and ethical standards and best practices, developed jointly by public and industry partners in a consensus-based approach; and 
(4) To create trial-ready IRP networks in the four disease areas of Major Depressive Disorder (MDD), Tuberculosis (TB), Non-Alcoholic Steatohepatitis (NASH) and Neurofibromatosis (NF).
Foundations and tools for client-side web security

The constantly increasing number of attacks on web applications shows how their rapid development has not been accompanied by adequate security foundations and demonstrates the lack of solid security enforcement tools.  Indeed, web applications expose a gigantic attack surface, which hinders a rigorous understanding and enforcement of security properties.  Hence, despite the worthwhile efforts to design secure web applications, users for a while will be confronted with vulnerable, or maliciously crafted, code.  Unfortunately, end users have no way at present to reliably protect themselves from malicious applications. 

BROWSEC will develop a holistic approach to client-side web security, laying its theoretical foundations and developing innovative security enforcement technologies.  In particular, BROWSEC will deliver the first client-side tool to secure web applications that is practical, in that it is implemented as an extension and can thus be easily deployed at large, and also provably sound, i.e., backed up by machine-checked proofs that the tool provides end users with the required security guarantees.  At the core of the proposal lies a novel monitoring technique, which treats the browser as a blackbox and intercepts its inputs and outputs in order to prevent dangerous information flows.  With this lightweight monitoring approach, we aim at enforcing strong security properties without requiring any expensive and, given the dynamic nature of web applications, statically infeasible program analysis.

BROWSEC is thus a multidisciplinary research effort, promising practical impact and delivering breakthrough advancements in various disciplines, such as web security, JavaScript semantics, software engineering, and program verification.
Promoting innovative clusters and value chain of SMEs for sustainable development 

The creation of economic opportunities through the promotion and development of the Mediterranean circular economy is the essence of CLUSTER4GREEN. In a vast part of the region, the leverage potential of circular economy is still lagging, deeply affecting the capacity of green sectors to generate wealth and jobs. CLUSTER4GREEN will take on the legacy of several previous projects that paved the way for the adoption of sustainable models of development, based on the circular concept, in industries like textile, building or smart cities. It will continue the green path with the generation of a “Common MED Circular Economy Programme” aimed at supporting both the green entrepreneurs and the local authorities responsible for the creation of an adequate green business environment. Innovative and sustainable business models will be elaborated and presented to a wide number of enterprises during specific training and assistance activities. As a final step on the green way, sustainable investment alliances will be established forging Public-Private Partnerships at national and international scale: as a result, the project will contribute to the “greening” of several Mediterranean industrial sectors at pilot level.
Betriebsmittelzuschuss für TRAKT

Das Projekt betrifft die Unterstützung des Unternehmers bei der Bereitstellung finanzieller Liquidität und die Unterstützung laufender Tätigkeiten aufgrund finanzieller Schwierigkeiten, die der Unternehmer infolge des COVID-19-Ausbruchs erlebt hat. Finanzielle Unterstützung im Rahmen des Programms SA.57015 (2020/N)
ASEPTIC CONNECTOR FOR FLUID CONDUITS

An aseptic connector includes first and second matable housings each comprising a plurality of connectors for fluid conduits. The fluid conduits enter the housings and may be force-fitted onto barbs or flanges on one side of the connectors, or may instead be molded directly onto the connectors. When the housings are joined, the opposite sides of the connectors mate to form fluid seals, thereby establishing fluid pathways between now-connected sets of tubes.
Shanghai FTA's Impact on Commercial Banks and Strategy

Shanghai FTA has important strategic significance. It is the realization of China miracle second season,the higher level of the active liberalization measure. Implementing regulatory model change,trade transformation and upgrading,financial institutional innovation of the three dividend for China's economic development,FTA will have three effect: reform demonstration effect,the combined effect of factors and regional linkage effects. To Commercial banks,Shanghai FTA provides new market opportunities and business space,while commercial banks in favor of strengthening business innovation. Therefore,commercial banks must attach great importance to policy signals FTA released,seize the opportunities of the financial system innovation to actively cope with the impact caused by the construction of the FTA through the strengthening of policy research,tracking customer demand and strengthen inter.nal and external linkage region,strengthening business innovation and ther measures.
Ecosystem mechanisms of noise impact on marine fauna

Defining a Good Environmental Status for ocean noise within the EU Marine Framework Strategy is challenged by our limited knowledge about noise effects on marine fauna.ECOSOUND proposes that there are two broad types of mechanisms of noise impact on individual animals, both with potential population-level effects: bottom-up, i.e. noise responses that operate at the genetic, cellular or physiological level, which are likely to be conserved across taxa; and top-down, i.e. behavioural reactions driven by the life style of each species, which may result in physiological damage and even death.ECOSOUND will study bottom-up effects exploring if noise may induce morphological changes in several invertebrate taxa, selecting study species known to show phenotypic plasticity when exposed to stressors. Identifying developmental mechanisms of noise-effects is critical to predict potential common physiological paths over a wide range of taxa.Top-down effects will be investigated by comparing the life style of four species of deep-diving whales, and developing models to identify the reasons and potential consequences at the individual and population level of the different vulnerability of these species to noise. ECOSOUND will use the largest existing dataset of multi-sensor acoustic tag recordings of these whales, and apply quantitative ecology methods to develop bioenergetics models linking foraging and diving behaviour, metabolic rate, life history and social structure of the species.The results will inform transfer functions for PCAD models of population consequences of acoustic disturbance.ECOSOUND will strengthen the multidisciplinary research profile of the fellow with the fields of developmental biology and quantitative ecology, while contributing expertise on cetacean biologging studies and a new research line on the impacts of noise on marine invertebrates to USTAN.Results are relevant for the EU Marine Framework Strategy in the emergent field of management of ocean noise
Drygro: efficient growth of crops in arid environments (degcae)

DryGro is an agriculture technology company that has developed an innovative new way to grow animal feed crops using very little water. This method uses large, 20m x 200m closed environment growing units to grow a high-protein animal feed crop called lemna, and can replace traditional animal feed staples like soy meal and sunflower cake which are very environmentally damaging. 

DryGro growing units have a number of advantages to traditional feed growing. Units are placed above ground, and thus avoid the need to compete with traditional growing methods for use of high quality arable land in the production process. Using this method, animal feed protein can be grown at a market price cheaper than is currently available on the market today. Current testing indicates that this method reduces water consumption per gram of protein by over 99%. DryGro technology increases yield per hectare by around 8x compared to traditional protein ingredients like soy. The market for feed produced by this technology is valued at over $150bn per year.  

The key USPs of DryGro's technology are: 
1) Ability to grow high-nutrient crops in areas otherwise unsuitable for agriculture; 2) 99% reduction in water consumption; 3) cost reduction of >50% per unit of output and 4) flexibility in choice of location, thus shortening supply chains and reducing costs. This feasibility study seeks to explore the technological and economic viability of expanding operations into three European target markets (Spain, Italy and Greece; selected as they face significant threats regarding aridity/desertification). It is hoped that the Phase 1 feasibility study will select the most suitable 1-2 markets of these countries, and underpin a Phase 2 application to enable DryGro to undertake trials in the target countries.
Evaluation of the effects of the metals Cd, Cr, Pb and their mixture on the filtration and oxygen consumption rates in catarina scallop, Argopecten ventricosus juveniles.

In this work, we evaluated the effect of sublethal concentrations ( LC25, LC10 and LC5) of cadmium, chromium, lead, and their mixture on the filtration rate and oxygen consumption rate of Catarina scallop, Argopecten ventricosus (Sowerby, 1842), juveniles, in order to evaluate the use of these biomarkers as a reliable tool in environmental monitoring studies, because these metals have been found at high levels in water and sediments in the Mexican Pacific systems. An inverse dose-response relationship was observed when metal concentration and exposure time increased, the filtration rate and oxygen consumption rate reduced. The physiological responses evaluated in this study were sufficiently sensitive to detect alterations in the organisms at 0.014 mg l(-1) Cd, 0.311 mg l(-1) Cr, 0.125 mg l(-1) Pb and 0.05 mg l(-1) Cd + Cr + Pb at 24 and 72 hrs. Cd showed the most drastic effect. The Catarina scallop juveniles were more sensitive to Cd, Cr and Pb as compared to other bivalves. The biomarkers evaluated are a reliable tool to carry out environmental monitoring studies.
Support for the maintenance of the Holiday Center “Czarski” Henryk Czarski

As a result of the restrictions put in place in connection with the emergence of the COVID 19 threat, my economic activity has become loss-making. Closed locations and a lack of guests caused a significant drop in revenues not only during the period of forced closure of the centre, but also during the period of so-called return to normality. The situation is still happening today. The funds raised from the grant will be used for current business activities, to cover running costs, stamp, insurance, tax and other charges.
Alternative <i>in vitro</i> assays in nanomaterial toxicology

Nanomaterials are acclaimed for their novel properties, for which broad new uses are being discovered with increasing frequency. It is obvious that, as the properties change, unwanted properties (toxicity) are to be expected as well. Current toxicology, however, is already overwhelmed with the challenge of addressing new chemicals, not to mention the enormous number of old chemicals never properly assessed. Limitations of traditional approaches range from animal welfare issues, which were a strong driving force for alternative approaches (the 3Rs concept) over the last two decades, to aspects of throughput and accuracy of the predicted toxicities. The latter has prompted discussion about a revolutionary change in chemical safety assessment, now known as Toxicology for the 21st Century (Tox-21c). The multitude of possible formulations of nanomaterials to be assessed for novel toxic properties makes these alternative approaches especially attractive, given the well recognized limitations of traditional animal-based approaches--limitations that might be even more pronounced for nanomaterials, which have notably altered biokinetics.
METHOD AND APPARATUS FOR SUPPORTING MIPV6 SERVICE IN A WIRELESS COMMUNICATION NETWORK

A method and apparatus for supporting a Mobile Internet Protocol (MIP) service based on Proxy Mobile IP (PMIP) in a portable Internet network is provided. In the method for supporting a MIP service based on PMIP in a portable Internet network including multiple subnets, a Portable Subscriber Station (PSS) performs an initial network entry procedure to a first subnet, and then acquires an IPv6 address that it uses as a Home of Address (HoA). A first Access Control Router (ACR) in the first subnet, configures an IPv6 address of the first ACR as a first Care of Address (CoA) of the PSS, and performs a MIPv6 registration procedure with a Home Agent (HA) using the HoA of the PSS and the first CoA. As a result, the PSS, even though it undergoes handover, has no need to perform a CoA acquisition procedure or its MIPv6-related procedure in the new subnet, making it possible to receive a seamless service without delay and packet loss for the ongoing service.
Tracing epigenetic evolution of triple-negative breast cancer towards chemo-resistance

The emergence of resistance to chemotherapy and targeted therapies is a major challenge for the treatment of cancer. While several genetic mechanisms driving resistance processes have been discovered, non-genetic mechanisms have also been shown to contribute to drug resistance. Yet, our restricted understanding of epigenetic evolution has so far limited our ability to modulate resistance using epigenetic modifiers. With ChromTrace, our goal is to reconstruct and define the contribution of epigenetic evolution to chemo-resistance in triple-negative breast tumors. In this aggressive sub-type of breast cancer, chemotherapy is the standard of care, but chemo-resistance remains the major unmet clinical need. We will explore the heterogeneity of H3K27me3chromatin states - key determinant of cell identity - in tumor cells, study how they are transmitted and determine whether they are associated to the resistance phenotype. 
Combining lineage tracing and targeted sequencing to our original single-cell chromatin profiling approach, we will reconstruct the dynamics of chromatin features over time in the context of genetic evolution. In parallel, using a live-cell microscopy reporter system, we will evaluate the association of recurrent chromatin features with the resistance phenotype and elucidate mechanisms of epigenetic tumor evolution. Our results on the heritability and plasticity of chromatin landscapes will have strong impact on our understanding of epigenetic evolution in cancer. Our long-term goal is to build on this integrated appreciation of molecular tumor evolution processes to propose novel therapeutic strategies to control resistance to chemotherapy. Finally, our approaches being applicable to any dynamic biological system, ChromTrace opens the perspective to study evolution of chromatin landscapes not only in other types of cancer and disease, but also during normal development.
Desgaste profesional en enfermeras durante la COVID-19, Hospital de segundo nivel en Ecuador

Introducción: El desgaste profesional ocurre tras la exposición sostenida al estrés crónico, tiene mayor connotación entre los profesionales sanitarios, principalmente las enfermeras, generando consecuencias amplias e importantes sobre la salud mental, física y el ejercicio profesional. Objetivo: detectar los niveles de desgaste profesional y la relación laboral que presentan las enfermeras que laboran en un hospital de segundo nivel en Manta, Manabí, Ecuador, durante la pandemia COVID-19. Método: se realizó un estudio descriptivo, transversal, no experimental, observacional y prospectivo. Se aplicó una encuesta durante el segundo trimestre del 2020, entre las enfermeras que laboraron en el área de emergencia COVID-19, se incluyeron variables sociodemográficas y laborales, el cuestionario Maslach Burnout Inventory. Se realizó análisis descriptivo e inferencial; se emplearon los estadísticos de Spermann. Resultados: Respondieron la encuesta 32 profesionales, con una población femenina en su totalidad; 22 profesionales (28,1%) no tenían estabilidad laboral; no se presentaron los 3 criterios positivos del síndrome, prevalecieron los niveles medios con 18.8 % cansancio emocional, 14.4% de despersonalización, mientras que la mayoría (78.1%) presentaba alta realización personal, el burnout moderado prevaleció en 87.5%, además, se observó una relación positiva y significativa (p=0.025), lo que reflejó que la relación laboral de contrato fue la más expuesta a un mayor desgaste profesional. Conclusión: en el área de emergencia COVID-19, las contratadas expresaron más compromiso en las 3 dimensiones, estos hallazgos resultan importantes para trazarse un estudio más amplio, y así establecer la detección temprana de esta patología que tiene implicaciones serias en el desempeño profesional.
Games of active life

The GOAL project provides a platform that fosters an ecosystem of games and applications that helps people stay motivated to lead socially engaged, physically and cognitively active lifestyles. The platform will benefit both players and third-party game developers. Players get to play their favourite games while at the same time working on a social and active lifestyle. Where certain GOAL games or applications will reward users for healthy behaviour, others allow the user to spend their earned GOAL Coins on virtual or real rewards. GOAL applications can reward among other, social interactions, physical activity, cognitive training, teamwork, and competition. Game developers choosing to integrate with the GOAL platform benefit by being able to leverage an easy to use platform that, when integrated into their games, provides out-of-the-box added value for their users’ healthy lifestyle. By leveraging the GOAL platform, game developers can focus on their strengths: to develop fun, engaging experiences for their users.
The GOAL platform provides a set of services to integrated games and health apps. First, the platform supports a complete virtual reward system in which applications function as coin generators, coin spenders or both. Second, the platform provides generic, adaptive personalized goal-setting that apps and games can leverage to automatically provide the most relevant challenge to their users. Third, an integrated motivational agent helps users achieving their health-, or in-game goals. Last, the platform includes a social marketplace that fosters social interactions among the GOAL community.
The GOAL platform has the potential to open up a new market in which health behaviour change components can be fully integrated in real, fun and engaging games. Game developers can focus on developing emerging experiences, while behaviour change experts provide the benefits in the GOAL platform.
Design and implementation of a FLC-based MPPT technique for photovoltaic systems

Photovoltaic (PV) energy is one of the most important renewable energy sources since it is clean, free and inexhaustible. To improve the conversion efficiency, a maximum power point tracking (MPPT) technique which has quick response and is able to track the peak power generated in any weather condition is required. In this paper, a novel Fuzzy Logic Controller (FLC) based MPPT technique for PV system is proposed. The proposed method can automatically adjust the step size to track the PV panel maximum power point (MPP). Comparing with the conventional fixed step size P&O method, the proposed approach can effectively address the tradeoff between the dynamics and steady state oscillations simultaneously. The design and implementation of the proposed method will be provided in this paper. Finally, simulation and experimental results will be provided to validate the effectiveness of the proposed method.
Ceftolozane/Tazobactam and Ceftazidime/Avibactam: An Italian Multi-center Retrospective Analysis of Safety and Efficacy in Children With Hematologic Malignancies and Multi-drug Resistant Gram-negative Bacteria Infections

Perruccio, Katia MD, PhD; Rosaria D’Amico, Maria MD; Baretta, Valentina MD; Onofrillo, Daniela MD; Carraro, Francesca MD; Calore, Elisabetta MD; Muggeo, Paola MD; Colombini, Antonella MD; Zama, Daniele MD; Meazza, Cristina MD; Cesaro, Simone MD Author Information