SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Safer and timely flights with automated foreign object detection system

The airport industry is a strategically important sector that makes a vital contribution to the EU's overall economy and employment by supporting 5 million jobs and contributing €300 billion to EU GDP. Despite the current economic crisis, global air transport is expected to grow by 5% annually till 2030 and airport operation companies are seeking methods to sustain FOD free runways for safer flights. Since, They generate costly breakdowns in planes, potential delays and cancellations, and eventually, also they are the cause of accidents and crashes. 
A-FOD is a FOD detection and management system comprised of a set of high resolution cameras connected to a AI system that is continuously trained by machine learning to solve the FODs detection problem. A-FOD is a complete FOD-hazard management system that allows airport maintenance teams to detect the smallest objects in any weather condition and also: 1) sends alerts to the operators; 2) provides live close-ups for a rapid visual verification without stopping the air traffic; 3) uses laser pointers and GPS to facilitate the removal and minimize its impact on the airport operation; 4) keeps records, in compliance with international regulations.
A-FOD is successfully tested in an airport used for amateur flights and a demo will be done at one of busies airport of Turkey at May’17.  Airports will gain high advantages by being able to -decrease delay time by %90-reduce required repair cost of FOD hazards-realize significant cost savings-gaining more satisfied customers. 
The main objective of A-FOD project is to minimise and solve the problems caused by FOD in airports. 
With an affordable solution that integrates AI functionalities and an integrated FOD management system, we aim to gain a leading position on the EU market until 2023. As a result of this project, we expect to reach a turnover above €46M, and we will create 59 direct jobs by the end of the 5th year of sales.
Exploring the diet-microbiota axis for immunomodulation and organ protection in hypertension

Essential hypertension damages organs such as the kidney, thereby leading to premature death. Beyond elevated blood pressure, hypertension is characterized by a pro-inflammatory immune response ahead of measurable organ damage. Activated immune cells infiltrate the kidney to cause tissue injury. However, inflammation is insufficiently addressed by today’s drugs. Current treatments do not include the gut microbiota, its metabolites and the associated lymphoid tissue – the largest immune cell reservoir in the body. We have recently shown for the first time that variations in dietary salt intake promote hypertension by modulating the immune system via the microbiota and its metabolites. Thus, the diet-microbiota axis is an important modulator of the immune response in hypertension. HyperBiota envisions a personalized, microbiome-guided immunonutrition for anti-inflammatory immunomodulation and organ protection in hypertension. It will explore the interplay between diet-dependent microbial metabolism in the intestine and the immune system in hypertension. By using an interdisciplinary approach, HyperBiota aims to 1) decipher the reciprocity of dietary composition, microbial community structure and metabolism, and immune response in hypertension. The identification of critical dietary and microbial components will enable targeted interventions. 2) Particular attention will be payed to worsening kidney function and how this affects microbial ecology and immune cell homeostasis. 3) It will investigate the extent to which the gut-associated lymphoid tissue contributes to the immune response in hypertension and its responsiveness to targeted interventions. 4) Knowledge gained in model systems will be translated and verified in mice associated with human microbial communities. Taking this approach, HyperBiota will cross borders and take a systems view on inflammation in hypertension to enable microbiome-guided immunonutrition for organ protection in hypertension.
In vitro comparison of the effect of inhalation delay on the variability of the delivered dose from valved holding chambers

The valved holding chamber (VHC) has been designed to optimize delivery for those using pressurized metered dose inhalers (pMDIs). We tested the effects on delivered dose of increasing delay between pMDI actuation and flow through the VHC, using both anti-static and conventional VHCs. Ten anti-static Diamond (Diamond; Philips Respironics) VHCs, anti-static AeroChamber Plus Z-Stat and conventional AeroChamber Plus (Z-stat and AC Plus; Monaghan Medical Corp.) VHCs were washed and air dried and six HFA albuterol sulfate pMDIs (ProAir HFA, 90 µg albuterol, Teva Specialty Pharmaceuticals LLC) were primed before use. For each run the pMDI was actuated into the VHC, after a delay of 0, 5 or 10 s flow through the VHC and attached filter occurred at an extraction flow rate of 5, 15 or 30 L/min for 10 s. The pMDI was actuated 10 times for each of the 10 VHCs of each brand at each delay/flow rate combination. Drug deposits were analyzed using HPLC. Results are presented as coefficient of variation of the delivered doses. The co-efficient of variation was highest for the conventional VHC for all test conditions. Use of an anti-static VHC can minimize variability (improve reproducibility) in delivered dose under in vitro test conditions.
landscapes and nature between tracks and ropes

The area between the Gotthard and the Simplon is affected by some important changes linked to the arrival of the "AlpTransit" and the entry into operation of the "Lötschberg". These large crossings allow the Alps to be quickly overcome. That profoundly modifies the perception of the Alpine context, its attractiveness and the catchment area. To face this challenge, the organization of a shared response across borders is fundamental, and it's necessary to start from the common promotion of the landscape and natural heritage._x000D_
In the Alps today there are trains (the green train of the Alps and the Red Train of Bernina) with a connection function, a strong impact on the tourist network that put together different transport systems (cable cars, boats, etc. ..) and which have a clear positioning and a series of high quality offers. The Vigezzina-Centovallina, which also connects with these trains, can become the blue train of the Alps.
Kojic Acid, a Cosmetic Skin Whitening Agent, is a Slow-binding Inhibitor of Catecholase Activity of Tyrosinase

Abstract It was found that kojic acid, which is used in cosmetics for its excellent whitening effect, inhibits catecholase activity of tyrosinase in a non-classical manner. A decrease in the initial velocity to a steady-state inhibited velocity can be observed over a few minutes. This time-dependence, which is unaltered by prior incubation of the enzyme with the inhibitor, is consistent with a first-order transition. The kinetic data obtained correspond to those for a postulated mechanism that involves the rapid formation of an enzyme inhibitor complex that subsequently undergoes a relatively slow reversible reaction. Kinetic parameters characterizing this type of inhibition were evaluated by means of nonlinear regression of product accumulation curves.
07 Use of the dog-isolated cardiac Purkinje fibre assay to investigate a compound with in vivo proarrhythmic activity

The dog-isolated cardiac Purkinje fibre assay is commonly used to assess the electrophysiologic effects of drugs known to prolong the QT interval. Drug-induced QT prolongation can be associated with Torsade de Pointes arrhythmias. The aim of this study was to determine if the dog Purkinje fibre assay could distinguish between Compound A, which produced ventricular premature complexes (VPCs) in vivo in the dog via an unknown mechanism, and Compound B, which is from the same chemical and pharmacological class as Compound A but did not produce VPCs. Action potentials (APs) were recorded and the number of VPCs counted. Phase 4 slope, action potential duration at 60 and 90% repolarisation (APD60 and APD90), maximum rate of depolarisation (MRD) and resting membrane potential (RMP) were also measured and compared to time-matched vehicle control. Compound A at 100 and 300 μM produced VPCs in 6/8 fibres from 3/3 dogs ranging from 1≥50 VPCs during stimulation to 3–16 VPCs following discontinuation of stimulation (
Training network providing cutting-edge knowledge on herpes virology and immunology

Herpesviruses are widely spread, and cause life-long infections. Most individuals carry multiple herpesviruses, which can cause severe diseases, especially in children, immunocompromised individuals, and elderly. There are currently no safe vaccines against herpesvirus infections and current treatments are not satisfactory. With new insights into the molecular basis for diseases caused by immunodeficiency, and with the increasing numbers of elderly in Europe, there is now an unmet demand for improved treatments of herpesvirus infections. Combined with the progress in basic herpesvirus research, this calls for education of a new generation of scientists with strong research skills, advanced insights into disease mechanisms, and understanding of how industry brings innovative research into the market. In this application we propose an interactive education program for early stage researchers (ESR) in leading European laboratories,  hospitals, and biotech companies. The focus will be on the virology and immunology of herpesvirus infections in the context of basic research as well as application of research-acquired knowledge. Our program will prepare the ESRs to manage goal-oriented interactions between academia, the clinics, and the biotech industry. The ESRs will acquire broad theoretical and methodological expertises involving several sectors to obtain the skills required for overcoming the cultural gaps From Bench to Bedside and From Discovery to Innovation. This can only be achieved through a network-based approach. We propose to develop a platform to educate the next generation of scientists to solve the outstanding problems in prevention and treatment of herpesvirus infections. The ESRs will be ideally trained to translate cutting-edge discoveries to novel products and to innovative treatment serving the European people, and hence to improve handling of present and emerging health challenges, as well as to foster the European biopharmaceutical industry sector.
A new large beaver (Mammalia, Castoridae) from the early Miocene of Japan

ABSTRACTA new early Miocene large castorid, Minocastor godai gen. et sp. nov., from the Dota locality, Gifu Prefecture in central Japan, is described on the basis of dentaries and teeth. The material comes from the Kani basin, where limnofluviatile clay and sandstones of the Nakamura Formation (Mizunami Group) are exposed on the southern (left) bank of the Kiso River. It represents the richest sample of a Miocene small mammal in the Japanese fossil record thus far known. Based on jaw and tooth morphology, this new castorid most likely represents a primitive anchitheriomyine. However, it lacks the marked striations on the incisors that are characteristic of the advanced large, middle Miocene anchitheriomyines like Anchitheriomys and Amblycastor. The new castorid shares this dental feature with other primitive anchitheriomyines from Asia and North America, like Propalaeocastor, Oligotheriomys, and Miotheriomys. For these genera, a new tribe, Minocastorini, is proposed as sister group to the Anchitheriomyini...
Flywheel with magnetic bearings.

Agencement de roue cinétique comportant un stator et un rotor et des paliers magnétiques pour suspendre magnétiquement le rotor par rapport au stator. Selon l'invention, pour les parties de palier magnétique liées au stator, on prévoit un système de suspension élastique (26), qui est raide dans une première direction parallèle à l'axe de rotation Z-Z du rotor, raide dans une seconde direction V-V orthogonale à l'axe de rotation du rotor et souple dans une troisième direction U-U orthogonale aux deux directions Z-Z et V-V.
SPINDLE DRIVE FOR A CLOSURE ELEMENT OF A MOTOR VEHICLE

The invention relates to a spindle drive for a closure element (2) of a motor vehicle (3), wherein a drive unit (4) and a downstream spindle/spindle nut mechanism (5), comprising a spindle (6), a spindle nut (7) and a spindle guide tube (8), for producing drive movements along a drive longitudinal axis (9) are provided, wherein the spindle drive (1) has drive connections (13, 14) for passing out the drive movements and being adjustable with respect to one another, wherein a first drive connection (13) is connected to the spindle guide tube (8) in an axially fixed manner, wherein a second drive connection (14) is connected to the spindle (6) in an axially fixed manner, wherein a drive spring (15) for producing drive movements along the drive longitudinal axis (9) is provided which acts on the drive connections (13, 14), wherein the spindle guide tube (8) has a first outer radius (a) along at least one axial portion. It is proposed that the spindle guide tube (8) has, on its side facing the first drive connection (13), a tube end portion (17) with a tube end edge (18), that the tube end portion (17) is widened radially over at least part of its circumference in such a way that the tube end edge (18) has an outer end edge radius (e) which is greater than the first outer radius (a), and that the widened tube end portion (17) secures the drive spring (15) against a movement along the drive longitudinal axis (9).
An FPGA-Based Novel Architecture for the Fixed-Point Binary Antilogarithmic Computation

Emerging embedded system applications require low power, fast and area-efficient implementation of complex arithmetic operations. Modern field-programmable gate array (FPGA) is a suitable candidate for implementing any reasonably complex architecture within minimal design time. Apart from the logic resources, most of the FPGAs contain hard-macro elements. By using a fixed-point data path, the available FPGA macro elements can be used to design an architecture that is much more complex. The realization of the complex arithmetic elements can be simpler by using a logarithmic number system. In this paper, a novel architecture and the FPGA realization of an antilogarithmic computing circuit is proposed. The proposed antilogarithmic circuit uses piecewise linear approximation method. The same architecture works for both the positive and negative binary numbers. A unique barrel-shifter is designed which shifts the input data to the left or right by the required amount. The proposed architecture is implemented in the Xilinx Virtex-5 xc5vfx70t device. The device utilization shows that the architecture utilizes a minimal FPGA resource. We have also performed error analysis of the approximation result. The error analysis shows that error associated with the positive numbers is 0.16% while that for the negative numbers is 0.8%. The error can be further minimized by taking more bits for the fractional bit representation.
A SYSTEM AND A METHOD FOR DETERMINING SAFE START-UP OF A REDUCING AGENT PROVISION CONFIGURATION

The invention relates to a method for determining safe start-up of a reducing agent provision configuration during relatively cold conditions.The method comprises the steps of determining a need of heating energy supply to there ducing agent provision configuration in order to provide safe start-up of there ducing agent provision configuration. This is performed on the basis of determined ambient temperature values corresponding to engine shut down and engine start as well as a determined time period during which the engine has been turned off. The invention relates also to a computer program product comprising program code (P) for a computer (200; 210; 500) for implementing a method according to the invention. The invention relates also to a system for determining safe start-up of a reducing agent provision configuration and a motor vehicle (100) equipped with the system.
Probiotics for the oncological patients

The main objective of this project is to perform the technological/comercial and economical viability of the newly developped very gentle form of microbial lysis which preserves the biologically active molecules of probiotic bacteria that favorably affects the cells of the intestinal mucosa and the mucosal immune system. This newly designed probioticsmodify the integrity of the intestinal mucosa damaged as a result of oncological treatment, to suppress inflammatory changes in the mucous membrane and, at the same time, to contribute to stabilization by the treatment of the disrupted microbiome.  The ONCOTICS introduces novel treatment of intestines infections which brings :  - Unique probiotical lysates product improving the oncology patients life comfort  -  New approach for elemination of syndrom leaky gut in oncological patients  -  Very safe gut barrier regeneration compared with standard probiotics, which can cuase sepsis  -  New patented technology for production of probiotics lysates  -  Novel therapy opening new markets
Novel cell migration assay based on microtissue technology and tissue-specific matrices

Cell migration assays are commonly used to study wound healing, cancer cell invasion, and tissue development. Problems associated with the gap closure assays typically employed are that: 
(i) the stopper or scratch used to make the migration zone damages the extracellular matrix (ECM), 
(ii) the migration zone size is limited by the size of the stopper, and 
(iii) the scratched migration zone shapes and sizes are irreproducible. Cell migration is strongly coupled with the structure and mechanical properties of the ECM, and damage to the ECM alters the cell migration path.

The main objective of this project is to develop a prototype novel cell migration assay, which will significantly improve the predictive power of cell-based assays while avoiding problems associated with existing assays, based on seeding cells precisely on pristine extracellular matrix tissue mimics with native-like cell-functionality and reproducible migration zones.

In accomplishing this, we will also address the following questions:
• What are the structure-property relationships between collagen I matrices with controlled thicknesses and fibril diameter and alignment, and their mechanical and electromechanical properties?
• What are the critical parameters for achieving functional bonding between the substrate and the highly anisotropic viscoelastic collagen I matrices and controlling the overall mechanical properties?
• Does the distribution of collagen fibril polar ordering, i.e., piezoelectric domains, influence cell migration?
• What parameters control crimp formation in tendon-like collagen I matrices?
• What parameters control and explain the unusual viscoelastic properties (e.g., they not depend on the speed of deformation, at least within the interval 0.01 - 1 mm/sec) of tendon-like collagen matrices?
• Which cell types, including cancer cells, co-align with collagen fibril alignment or crimp direction?
Assessment of cancer risk in two rural West Texas communities using anthropometrics, diet, and physical activity

Cancer risks in the United States are linked to undesirable dietary and physical activity habits that may be more common in rural communities. This study assessed the cancer risk in two rural West Texas communities through anthropometrics, diet, and physical activity measures (n = 374). No significant relationships were found between body mass index (BMI) and waist circumference (WC) with consumption of fruits, vegetables, whole grains, and sugar-sweetened beverages; however, data showed significant negative associations between BMI and WC and physical activity. Over 58% of the sample was unaware of the link between obesity and cancer risk. Further evaluation of cancer risk in rural communities is needed to develop effective interventions and reduce health disparities.
Shining through the galaxy: dark matter signals versus astrophysical backgrounds

The nature of dark matter (DM) is one of the greatest mysteries in modern physics. It is well established to constitute 26% of the total energy-matter of the universe, to drive the motion of stars and galaxies, and to have shaped the universe as we observe it today. We know how DM interacts gravitationally with standard matter, but what we do not yet understand are its nature and particle properties.
A general prediction of theoretical DM models is that dark matter particles self-interact producing high-energy photons and charged particles at rates detectable by current ground- and space-based telescopes. Discovering such a signal would allow us to study the particle properties of DM for the very first time.
In a recent exciting development, an anomalous emission in the gamma rays coming from the centre of our Galaxy has been measured, the so-called Galactic centre GeV excess: this could be the very first signature of the presence of DM there. 
My project will carry out definitive tests of this putative first non-gravitational signature of the DM particle nature by studying the gamma-ray sky. Firstly, I will improve the sensitivity and reliability of searches for DM in the inner region of the Galaxy - one of the most promising targets - thanks to novel analysis methods. The unprecedented accuracy of the data available requires theory to provide robust predictions for the DM distribution in the Galaxy, which are currently missing. I will remedy this by using the most recent simulations of galaxy formation to predict the DM induced signal.
My project will considerably boost astroparticle physics research towards the identification of the much-sought after DM by developing new methods for gamma-ray data analysis and for DM models testing. Owing to the designed program, I will bring new expertise to the Imperial College Astrophysics Group and use this experience to grow into a senior researcher.