SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Abstract 4239: Differentiation and apoptosis induced by all-trans retinoic acid is associated with downregulation of peroxiredoxin 1 in myeloid leukemia cells

All-trans retinoic acid (ATRA) based differentiation therapy with potentially curative outcome in acute promyelocytic leukemia (APL), has limited benefit in non-APL acute myeloid leukemia (AML). Thus, identifying key mediators of ATRA-induced differentiation/apoptosis in AML cells may reveal new putative therapeutic targets. Previously, we reported (Leukemia 20: 1809, 2006) that the therapeutic efficacy of ATRA is enhanced in topoisomerase 2β (TOP2β)-deficient AML cell lines, both APL (HL-60, AP-1060) and non-APL (KG-1), in part due to decreased expression of the antioxidant enzyme, peroxiredoxin (PRDX) 2 and increased accumulation of reactive oxygen species (ROS). Based on preliminary observations that (a) ATRA leads to down-regulation of a related antioxidant protein, PRDX1 (RNA array analysis), and (b) PRDX1 mRNA expression relative to PRDX2 mRNA is significantly higher in HL-60, KG-1, and leukemic blast cells from 20 AML patients (qRT-PCR analysis), we evaluated the role of PRDX1 in sensitizing the apoptotic effects of ATRA. Specifically, we tested the hypothesis that ATRA induced growth arrest/apoptosis is associated with decreased PRDX1 levels and increased ROS, which can be modulated by TOP2β. Accordingly, downregulation of TOP2β can enhance apoptosis by increasing ROS, whereas overexpression of TOP2β can inhibit PRDX1 downregulation by ATRA and attenuate ROS-induced apoptosis. Treatment of HL-60, KG-1 and patient AML blast cells with 1 µM ATRA in the absence or presence of 0.1 µM ICRF193 (TOP2β catalytic inhibitor) led to a 3 to 4-fold decrease in PRDX1 mRNA and protein. No effect of ICRF193, which leads to degradation of TOP2β, was observed on PRDX1 levels. Interestingly, while treatment with ATRA + ICRF 193 did not enhance PRDX1 down regulation compared to ATRA alone, it did lead to significantly (p Citation Format: Eric J. Norris, Yogin C. Patel, Michaela B. Reinhart, Ram N. Ganapathi, Mahrukh K. Ganapathi. Differentiation and apoptosis induced by all-trans retinoic acid is associated with downregulation of peroxiredoxin 1 in myeloid leukemia cells. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 4239. doi:10.1158/1538-7445.AM2014-4239
Naturally, a Ride with senses

The territory in which the project is developed represent an ideal hinge between the close attractive urban areas (Turin, Cuneo, Annecy) and Lanzo, Cuneo Valley and territories of the Haute-Savoie. Parco La Mandria, Parco Gesso e Stura and the Farm of Chosal areas are deeply rural and green, but, in despite of it, these areas don’t have a enough infrastructure and a real welcome strategy to become an attractive place, to develop an easy and inclusive environmental tourism. The project born from the sharing of these problematics and reunites four partners bringing specific competences in different sectors; a Park (instrument institution of the Piemonte Region), a local institution (Cuneo City), two institutions (the cooperative Arnica of Turin and the Farm of Chosal in Haute-Savoie) wich manage a lot of activities with prevised targets especially a public with motor, visual or mental disability, elders and families with children. 
In summary, the project aims to realise a cross-border network of sensorial paths and of barefooting to attract a tourism of discovery, ludic and experiential, which help to overpass the difficulties of contact woth nature, creating new forms of eco-tourism for all, during every season of the year. NAT.SENS answers to a real need of rapprochement to nature in rural areas and middle mountain, to a request of experiential tourism, and a need to meet, share and discover new touristic offers.
Concurrency testing using schedule bounding

We present the first independent empirical study on schedule bounding techniques for systematic concurrency testing (SCT). We have gathered 52 buggy concurrent software benchmarks, drawn from public code bases, which we call SCTBench. We applied a modified version of an existing concurrency testing tool to SCTBench to attempt to answer several research questions, including: How effective are the two main schedule bounding techniques, preemption bounding and delay bounding, at bug finding? What challenges are associated with applying SCT to existing code? How effective is schedule bounding compared to a naive random scheduler at finding bugs? Our findings confirm that delay bounding is superior to preemption bounding and that schedule bounding is more effective at finding bugs than unbounded depth-first search. The majority of bugs in SCTBench can be exposed using a small bound (1-3), supporting previous claims, but there is at least one benchmark that requires 5 preemptions. Surprisingly, we found that a naive random scheduler is at least as effective as schedule bounding for finding bugs. We have made SCTBench and our tools publicly available for reproducibility and use in future work.
The use of crossbreeding with beef bulls in dairy herds: effects on calving difficulty and gestation length

This study was designed to analyse the evolution in the use of beef bull semen for dairy cattle insemination and, mainly, to assess calving difficulty, gestation length and proportion of stillbirths after breeding pure Holsteins or crossbreeding. Data were collected during 2004 to 2011 for 552 571 Holstein calvings (457 070 Holstein × Holstein, 43 384 Holstein × Limousine, 32 174 Holstein × Belgian Blue and 19 943 Holstein × Galician Blonde). The highest calving difficulty, compared with pure Holsteins was for crosses with Belgian Blue followed by Limousine and Galician Blonde. The Holstein × Limousine and Holstein × Galician Blonde crossbred calves had significantly longer gestation lengths than Holstein × Holstein and Holstein × Belgian Blue calves. Between the latter two, pure Holstein had the shortest gestation length. Calving difficulty and gestation length decreased as the age of the dam advanced. The most difficult calvings were observed in twin calvings, followed by the calvings of male calves and female calves. The gestations leading to the birth of male calves were longer than those leading to female calves and twin calves. Stillbirths were not related to the breed used for mating. Through examining these parameters, sire breed should be considered when selecting a beef breed for the insemination of milk-producing dams.
Analysis of combined data from heterogeneous study designs: an applied example from the patient navigation research program

Background The Patient Navigation Research Program (PNRP) is a cooperative effort of nine research projects, with similar clinical criteria but with different study designs. To evaluate projects such as PNRP, it is desirable to perform a pooled analysis to increase power relative to the individual projects. There is no agreed-upon prospective methodology, however, for analyzing combined data arising from different study designs. Expert opinions were thus solicited from the members of the PNRP Design and Analysis Committee. Purpose To review possible methodologies for analyzing combined data arising from heterogeneous study designs. Methods The Design and Analysis Committee critically reviewed the pros and cons of five potential methods for analyzing combined PNRP project data. The conclusions were based on simple consensus. The five approaches reviewed included the following: (1) analyzing and reporting each project separately, (2) combining data from all projects and performing an individual-level analysis, (3) pooling data from projects having similar study designs, (4) analyzing pooled data using a prospective meta-analytic technique, and (5) analyzing pooled data utilizing a novel simulated group-randomized design. Results Methodologies varied in their ability to incorporate data from all PNRP projects, to appropriately account for differing study designs, and to accommodate differing project sample sizes. Limitations The conclusions reached were based on expert opinion and not derived from actual analyses performed. Conclusions The ability to analyze pooled data arising from differing study designs may provide pertinent information to inform programmatic, budgetary, and policy perspectives. Multisite community-based research may not lend itself well to the more stringent explanatory and pragmatic standards of a randomized controlled trial design. Given our growing interest in community-based population research, the challenges inherent in the analysis of heterogeneous study design are likely to become more salient. Discussion of the analytic issues faced by the PNRP and the methodological approaches we considered may be of value to other prospective community-based research programs.
Analysis and new structure of the industrial development program

The article presents the analysis of the Ukrainian “State program of industrial development during 2003 – 2011”. The following basic elements of the program as “The general terms”, “The goal and the stages of an industry development”, “Reforming the system of an industry management”, “Acceleration of institutional reforms”, “Improvement the structure of an industrial production”, “Enforcement of innovational direction of an industrial development”, “Enlargement of competitive advantages of an industry” and “Financial and resource support of the program” are analyzed in the report. The major shortcomings of the program, which are generally connected with the incorrect definition of the goal and the main tasks, the lack of detailed measures and arrangements in the program, have been determined in the article. On the basis of the revealed drawbacks of the program, a new structuring of this branch document has been proposed. It includes the complex of interrelated projects, directed at elaboration and implementation of new mechanisms of competition regulation, improvement of tax privileges for industrial enterprises, elaboration of mechanisms of privileged financing of industrial sector by commercial banks and by means of capital issues emission and distribution, elaboration of mechanisms of industrial clusters forming in Ukraine, as well as elaboration of mechanisms of privileged financing of industrial research and development (R&amp;D) programs.
METHOD AND CABLE FOR CONNECTING ELECTRONIC EQUIPMENT TO ANOTHER ELECTRONIC EQUIPMENT

The present invention is a connection method and a connecting cable, which can significantly improve the transmission of low-frequency signals as well as the undesired radiation level of high-frequency signals. To connect electronic devices (1a) and (1b) by a connecting cable (4), the part between one and the other end of the signal line (2) of a connecting cable is shielded by a first external conductor (3a), one end of the first external conductor (3a) being connected to reference potential of the electronic device (1a), the first external conductor (3a) being shielded by a second external conductor (3b), and the second external conductor (3b) is connected to reference potential of the second electronic device (1b), whereby the reference potential of one electronic device and the reference potential of the other electronic device are coupled through a stray capacity between the first external conductor (3a) and the second external conductor (3b), and the length of opposition between the first external conductor (3a) and the second external conductor (3b) is adjusted according to a frequency with which undesired radiation is to be suppressed. <IMAGE>
Forming of fiber assembly

The present invention provides a method for forming a fiber assembly by air blowing, enabling the fiber assembly to be fed continuously into a mold cavity even without the need of weighting it in advance, also enabling it to be uniformly packed into the cavity. In this method for forming a fiber assembly, designed to pack a mold cavity with the opened fiber assembly accompanying air to subject it to thermoforming after preparing the fiber assembly by blending a matrix of crimped staples of synthetic fiber with binder fibers lower in melting point that the staples, the pressure change of the air flow accompanied in packing the fiber assembly into the cavity as the packing advances is detected by pressure gauges; at a point when the pressure change comes to a level indicating completion of the packing, the packing operation is halted.
Water Saving for Development

The general objective of the project is to promote drinking water saving culture & behaviour . Its principal activities are: • on line geo-referred maps regarding existing water resources/quality and water needs, for Puglia and Achaia • a Sustainable cross border Water Management Plan • a water saving “Local Action Plan - 2015-2020” • “Water Houses” with scenic design selected via public competition • a Water Saving Promotion and Awareness Campaigns • Workshops on water-saving, mainly addressed to expert and technicians • Transfer of an e-service on water issues (sportelloacqua.it), to Achaia Region • an educational e-tool on sustainable living, in facebook
Sulfur mustard induces an endoplasmic reticulum stress response in the mouse ear vesicant model

The endoplasmic reticulum (ER) stress response is a cell survival pathway upregulated when cells are under severe stress. Severely damaged mouse ear skin exposed to the vesicant, sulfur mustard (bis-2-chloroethyl sulfide, SM), resulted in increased expression of ER chaperone proteins that accompany misfolded and incorrectly made proteins targeted for degradation. Time course studies with SM using the mouse ear vesicant model (MEVM) showed progressive histopathologic changes including edema, separation of the epidermis from the dermis, persistent inflammation, upregulation of laminin γ2 (one of the chains of laminin-332, a heterotrimeric skin glycoprotein required for wound repair), and delayed wound healing from 24h to 168h post exposure. This was associated with time related increased expression of the cell survival ER stress marker, GRP78/BiP, and the ER stress apoptosis marker, GADD153/CHOP, suggesting simultaneous activation of both cell survival and non-mitochondrial apoptosis pathways. Dual immunofluorescence labeling of a keratinocyte migration promoting protein, laminin γ2 and GRP78/BIP, showed colocalization of the two molecules 72h post exposure indicating that the laminin γ2 was misfolded after SM exposure and trapped within the ER. Taken together, these data show that ER stress is induced in mouse skin within 24h of vesicant exposure in a defensive response to promote cell survival; however, it appears that this response is rapidly overwhelmed by the apoptotic pathway as a consequence of severe SM-induced injury.
PERCUTANEOUS CIRCULATORY SUPPORT DEVICE INCLUDING RECONFIGURABLE DISTAL TIP PORTION

A percutaneous circulatory support device includes a housing and an impeller disposed within the housing and being rotatable relative to the housing to cause blood to flow through the housing. A cannula is coupled to the housing, and a distal tip portion is coupled to the cannula opposite the housing. A control wire is movable to modify at least one of a radius, a stiffness, and a shape of the distal tip portion.
Comparison of genetic difference in cultured Pampus populations between China and Kuwait based on COI partial sequences

In order to investigate genetic variance and genetic diversity between China and Kuwait cultured populations of silver pomfret, COI partial sequences were compared and analyzed. By PCR amplification and sequencing, 47 sequences were obtained, and 8 haplotyes were defined. The polymorphic sites in China and Kuwait populations were 4 and 14, respectively. The contents of A+T are higher than G+C in each populations, and both populations showed higher levels of haplotype diversity(0.566~0.643) and lower levels of nucleotide diversity(0.0022~0.0030). Results of NJ phylogenetic tree and genetic distance suggest that cultured pampus in two countries have significant genetic variance, and should be viewed as two different species.
Consensus in acute myeloid leukemia in Mexico

Acute myeloid leukemia (AML) comprises a heterogeneous group of hematopoietic cell neoplasms of myeloid lineage that arise from the clonal expansion of their precursors in the bone marrow, interfering with cell differentiation, leading to a syndrome of bone marrow failure. AML is a consequence of genetic and epigenetic changes (point mutations, gene rearrangements, deletions, amplifications, and arrangements in epigenetic changes that influence gene expression) in hematopoietic precursor cells, which create a clone of abnormal cells that are capable of proliferating but cannot differentiate into mature hematopoietic cells or undergo programmed cell death. The diagnosis requires more than 20% myeloid blasts in the bone marrow and certain cytogenic abnormalities. Treatment will depend on age, comorbidities, and cytogenetic risk among the most frequent.La leucemia mieloide aguda (LMA) comprende un grupo heterogéneo de neoplasias de células hematopoyéticas de linaje mieloide que surgen de la expansión clonal de sus precursores en la médula ósea, interfiriendo con la diferenciación celular, lo que conlleva a un síndrome de falla medular. La LMA es una consecuencia de cambios genéticos y epigenéticos (mutaciones puntuales, rearreglos de genes, deleciones, amplificaciones y arreglos en cambios epigenéticos que influyen en la expression del gen) en las células hematopoyéticas precursoras, la cual crea una clona de células anormales que son capaces de proliferar, pero no se pueden diferenciar en células hematopoyéticas maduras ni sufrir una muerte celular programada. El diagnostic requiere más del 20% de blastos mieloides en médula ósea y ciertas anormalidades citogénicas. El tratamiento dependerá de la edad, comorbilidades, riesgo citogenético entre las más frecuentes.
Cryogenic Core Collection (C3) from Unconsolidated Subsurface Media

We evaluated tools and methods for in situ freezing of cores in unconsolidated subsurface media. Our approach, referred to as cryogenic core collection (C3), has key aspects that include downhole circulation of liquid nitrogen (LN) via a cooling system, strategic use of thermal insulation to focus cooling into the core, and controlling LN back pressure to optimize cooling. Two cooling systems (copper coil and dual-wall cylinder) are described. For both systems, the time to freeze a single 2.5-foot (76-cm) long by 2.5-inch (63-mm) diameter core is 5 to 7 min. Frozen core collection rates of about 30 feet/day (10 m/day) were achieved at two field sites, one impacted by petroleum-based light nonaqueous phase liquids (LNAPLs) and the other by chlorinated solvents. Merits of C3 include (1) improved core recovery, (2) potential control of flowing sand, and (3) improved preservation of critical sediment attributes. Development of the C3 method creates novel opportunities to characterize sediment with respect to physical, chemical, and biological properties. For example, we were able to resolve water, LNAPL, and gas saturations above and below the water table. By eliminating drainage of water, gas and LNAPL saturations in the range of 6 to 23% and 1 to 3% of pore space, respectively, were measured in LNAPL-impacted intervals below the water table.
ARTICULATED TRACKED VEHICLE

The invention relates to an articulated tracked vehicle comprising a first vehicle unit and a second vehicle unit controllably connected by means of a control member, wherein the first vehicle unit comprises a combustion engine, wherein the combustion engine is arranged to drive a generator for electrical generation, wherein the generator is arranged to transfer power via power electronic means to at least one electric motor of at least one electric propulsion unit.
Creation of telecenters to support learning, entrepreneurship and access to IS, in isolated areas

More than 14 million households in remote areas of Europe have difficulties in accessing information and communication technologies (ICTs). Particularly in rural regions tele-density is low compared to urban centres. Despite many programmes focusing on this issue, the so-called digital divide is ever increasing. Until now transfer rates tend to be lower in rural areas which limits the introduction of advanced services, like e-Health and e-Learning, as well as organisational development. The provision of broadband connections through telecentres in remote areas can help to solve this problem. Project partners of TELEACCESS come from regions with shared past experiences concerning ICT and spatial development issues. Aim of the project is to foster the digital culture among rural citizens to enable remote areas the access to the information society. For this, existing local establishments are converted into pilot telecentres. These should function as a hub to provide the local labour force and citizens of all ages with faster access to the Internet. Target groups and beneficiaries of the project are all citizens of the participating regions as well as regional and local authorities, including municipalities, prefectures and other local institutions, such as schools and libraries.
Nueva especie de tabulado del Dévonico Inferior de Argentina

Se describe una nueva especie de coral tabulado, Parastritapora sanjuanmina, procedente de dos localidades situadas en la zona sur de la Precordillera Argentina. El material estudiado procede de varios niveles carbonatados situados en la base de la Fm Talcasto cuya edad es Lochkoiviense inferior. La nueva especie se asigna un género Parastriatopora y está caracterizada por la presencia de una zona axial reducida, constituida por un escaso número de coralitas y por el importante desarrrollo de un reborde periférico compacto en las ramas maduras. Externamente, las ramas muestran cálices ornamentados por entre ocho y doce crestas separadas por ocho depresiones puntiformes.
Schools of citizenship: parent councils at public schools in italy, spain, and france

In the wake of economic, climate, and violent crises throughout the Mediterranean region, Europe has recorded more asylum seekers and immigrants during the past decade than ever before. As these new populations seek to integrate into European society, the following questions arise: are there sufficient institutional sites and resources to civically incorporate these incoming individuals and families? More importantly, what are the appropriate and practically effective institutions to build shared values of tolerance, respect, and citizenship? The purpose of this interdisciplinary project is to investigate the public institution most directly responsible for civic education, public schools, in three of the highest immigrant destination countries in Europe: Italy, Spain, and France. Yet while most European wide civic education initiatives focus on school children, the focus of this study is parent participation on parent councils (assemblee genitori, asociación de padres, conseil des parents d'élèves) at schools. In many nation states throughout Europe, parents have the right and expectation to participate at schools through legally codified parent councils, yet they remain little understood as a vehicle for productive civic integration. This absence in the scholarly literature and European institutional initiatives is surprising given the established finding that schools are the primary public institution where immigrants interface with others and participate civically. In sum, parent councils at public schools are uniquely situated as a civic educational institution and remain nearly absent from citizenship education initiatives in Europe. In an effort to illuminate the viability of parent councils for civic integration, this study utilizes a mixed-method framework to build a conceptual understanding through qualitative methods in the first phases of research which inform a representative survey of parent members in the final phase of the study.