SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Engineering the protein corona on rna nanoparticles for improved nucleic acids-based therapies delivery

In the past three decades, nanomedicine has emerged as a promising strategy in cancer treatment and has led to numerous proposed drug delivery systems. Nanoparticles aim to improve selectivity towards cancer cells while reducing off-target effects and toxicity towards normal cells. Among these systems, self-assembled RNA nanoparticles have been of great interest for drug delivery, because of their low cost, high yielding assembly and retained functionality. Yet, challenges such as poor nuclease resistance, biodistribution and cellular delivery remains to be addressed, to fully propels these structures towards clinical applications. To optimize these systems, there is a huge need to understand precisely their interactions with biological components. In particular, upon injection in vivo, it is known that serum proteins adsorb on nanoparticles. The composition of this so-called protein-corona on RNA particles remains fully unexplored. 

Herein, I propose to characterize the protein corona on RNA nanoparticles using state-of-the-art methodologies (proteomics, super-resolution microscopy, SELEX), as well as understand the role the corona on the fate of RNA structures. I will engineer the protein corona to improve biological outcomes of RNA particles, previously developed by Sixfold Bioscience Ltd. Overall, the project aims at providing tools and rules for rational engineering of the protein corona. In the long term, the project, grouping experts in industry and in academia, aims towards the development of a preclinical candidate, as well as answering fundamental questions on nanoparticles delivery.
Effects of Magnetic Field on Entropy Generation in Flow and Heat Transfer due to a Radially Stretching Surface

We investigate the effects of magnetic field on the entropy generation during fluid flow and heat transfer due to the radially stretching surface. The partial differential equations governing the flow and heat transfer phenomenon are transformed into nonlinear ordinary differential equations by using suitable similarity transformations. These equations are then solved by the homotopy analysis method and the shooting technique. The effects of the magnetic field parameter M and the Prandtl number Pr on velocity and the temperature profiles are presented. Moreover, influence of the magnetic field parameter M and the group parameter Br/Ω on the local entropy generation number Ns as well as the Bejan number Be are inspected. It is observed that the magnetic field is a strong source of entropy production in the considered problem.
Fault-zone structure and weakening processes in basin-scale reverse faults: The Moonlight Fault Zone, South Island, New Zealand

Abstract The >200 km long Moonlight Fault Zone (MFZ) in southern New Zealand was an Oligocene basin-bounding normal fault zone that reactivated in the Miocene as a high-angle reverse fault (present dip angle 65 ° –75 ° ). Regional exhumation in the last c. 5 Ma has resulted in deep exposures of the MFZ that present an opportunity to study the structure and deformation processes that were active in a basin-scale reverse fault at basement depths. Syn-rift sediments are preserved only as thin fault-bound slivers. The hanging wall and footwall of the MFZ are mainly greenschist facies quartzofeldspathic schists that have a steeply-dipping (55 ° –75 ° ) foliation subparallel to the main fault trace. In more fissile lithologies (e.g. greyschists), hanging-wall deformation occurred by the development of foliation-parallel breccia layers up to a few centimetres thick. Greyschists in the footwall deformed mainly by folding and formation of tabular, foliation-parallel breccias up to 1 m wide. Where the hanging-wall contains more competent lithologies (e.g. greenschist facies metabasite) it is laced with networks of pseudotachylyte that formed parallel to the host rock foliation in a damage zone extending up to 500 m from the main fault trace. The fault core contains an up to 20 m thick sequence of breccias, cataclasites and foliated cataclasites preserving evidence for the progressive development of interconnected networks of (partly authigenic) chlorite and muscovite. Deformation in the fault core occurred by cataclasis of quartz and albite, frictional sliding of chlorite and muscovite grains, and dissolution-precipitation. Combined with published friction and permeability data, our observations suggest that: 1) host rock lithology and anisotropy were the primary controls on the structure of the MFZ at basement depths and 2) high-angle reverse slip was facilitated by the low frictional strength of fault core materials. Restriction of pseudotachylyte networks to the hanging-wall of the MFZ further suggests that the wide, phyllosilicate-rich fault core acted as an efficient hydrological barrier, resulting in a relatively hydrous footwall and fault core but a relatively dry hanging-wall.
Commentary: new development goals must focus on social determinants of health

Although the millennium development goals (MDGs) addressed some of the starkest manifestations of the contemporary global health crisis, they failed to confront the underlying structures that maintain the crisis, including globalisation. In reflecting on the post-2015 development agenda,1 we need to challenge some key assumptions about the genesis and effect of the current goals. 

Much of the discourse around the MDGs since 2000 has suggested that attainment would be secured by creating a global partnership for development (goal 8) and would require “more of the same,” including increased development assistance. An alternative interpretation is that both the goals and the increased development assistance since 2000 were motivated, at least in part, by the need to shore up the legitimacy of what was …
Luminescence of Yb-doped YAG: Divalent ytterbium ions

Abstract This study reports the presence of Yb 2+ ions with 4f 13 6s electron configuration of the ground state in addition to Yb 3+ ions in yttrium aluminium garnet ceramics activated by ytterbium. Pulsed cathodoluminescence and transmission spectra of divalent ytterbium ions appear as narrow lines of s↔s transitions at 913–1050 nm range. These ions in association with oxygen vacancies generate Re–F centres which are able to absorb at 280, 365, 630 nm and emit at 325, 520, 590−720 nm in d↔s transitions of Yb 2+ ions; the emission band at 590–720 nm consists of eight narrow lines. The Re–F centeres are manifested most clearly in the ceramic samples obtained directly after vacuum sintering at 1800 °C.
A comparative investigation on adsorption performances of mesoporous activated carbon prepared from waste rubber tire and activated carbon for a hazardous azo dye—Acid Blue 113

A mesoporous carbon developed from waste tire rubber, characterized by chemical analysis, FTIR, and SEM studies, was used as an adsorbent for the removal and recovery of a hazardous azo dye, Acid Blue 113. Surface area, porosity, and density were determined. The adsorption of the dye over the prepared adsorbent and a commercial activated carbon was achieved under different pH, adsorbate concentration, sieve size, adsorbent dosage, contact time and temperature conditions. Langmuir and Freundlich adsorption isotherm models were applied and thermodynamic parameters were calculated. Kinetic studies indicated that the adsorption process follow first order kinetics and particle diffusion mechanisms are operative. By percolating the dye solution through fixed-bed columns the bulk removal of the Acid Blue 113 was carried out and necessary parameters were determined to find out the percentage saturation of both the columns. Recovery of the dye was made by eluting 0.1 M NaOH through the column.
REDUNDANT STORAGE CONTROLLER SYSTEM WITH ENHANCED FAILURE ANALYSIS CAPABILITY

A redundant storage controller system that robustly provides failure analysis information (FAI) to an operator of the system is disclosed. The system includes first and second storage controllers in communication with one another, such as via a PCI-Express link. When one of the controllers fails, the FAI is transferred from the failed controller to the surviving controller over the link. The operator issues a command to the surviving storage controller, which responsively provides the FAI. In one embodiment, the failed storage controller writes the FAI to the second storage controller. In one embodiment, each storage controller periodically writes the FAI before there is a failure. In one embodiment, the second storage controller reads the FAI from the failed storage controller. The FAI may include boot logs, crash logs, debug logs, and event logs. The FAI may also be written to a disk drive connected to the controllers.
Reconsidering european contributions to global justice

GLOBUS critically assesses the EU’s impact on justice in a global system characterised by uncertainty, risk and ambiguity. GLOBUS defines a new research agenda for the study of the EU’s global role. This agenda directs attention to underlying political and structural challenges to global justice that are prior to the distributive problem, as well as to the fact that what is just is contested both by theorists and policy makers. GLOBUS provides in depth knowledge of how the EU proceeds to promote justice within the specific fields of climate change, trade, development, asylum/migration and security while also speaking to the key horizontal issues of gender and human rights within each of these fields. Rather than focusing on a single dimension GLOBUS develops three different conceptions of justice. This nuanced conceptual scheme allows GLOBUS to address the multifaceted challenge of justice, and to specify the EU’s real impact. GLOBUS takes heed of the reality of “the foreign will” through intense engagement with partners outside Europe. This provides a ‘reality check’ of the limits and potential for the EU’s future place in a multi-polar order. The three conceptions of justice as non-dominance, as impartiality and as mutual recognition all have limitations as they prioritise some challenges to global justice over others. These limitations are important in order to empirically discern inhibiting factors for global political justice– such as power, unequal competences and the prevailing ‘system of states’ – as well as in order to specify how the EU contributes to justice. In order to develop a feasible model of justice promotion, we return to theory when data is collected and revise and amend the analytical model. We further factor in the viewpoints and experience of practitioners and stakeholders, GLOBUS provides policy-relevant recommendations that take into consideration ideal requirements while at the same time not losing sight of the realities of power.
Integrated and Sustainable Transport in Efficient Network

ISTEN aims at qualifying ADRION Ports as strategic nodes and hubs for the ADRION Region by setting up strategies, a transnational cooperation network and a joint action plan to improve hinterland intermodal connections, pushing in particular rail freight flows and last mile connection to the TEN-T Corridors. At present a lack of cooperation, sharing infrastructure (hard&soft) among relevant actors and massive road congestion problems, affecting links port-hinterland, are significant limits to efficiency. To date 74% of EU trade goes by ship and 37% of the total intra-EU exchange of goods (in tonne-km) goes through the EU’s ports (source EC, Ports: gateways of the TEN-T). 27% of freight in EU ports is handled in Mediterranean Ports and by 2030 traffic is expected to rise by 50%. It is clear that infrastructures and transport services must be updated in order to be ready to receive this volume of freight. ISTEN involves ports from Italy, Croatia, Slovenia, Greece, Albania and Montenegro as main gateways to the TEN-T and Motorway of the Sea. Main objectives of the project are to: _x000D_
1) steer priorities of involved territories by identifying integrated infrastructure planning at transnational level and consistent investment strategies; _x000D_
2) provide guidelines & criteria for defining legal, technical and operational conditions useful to establish an efficient ADRION transnational network; _x000D_
3) develop a specific innovative Toolbox to be used by relevant actors to analyse and define suitable conditions for establishing robust networks of stakeholders; _x000D_
4) define IT solutions and services for the communication and knowledge management; _x000D_
5) capacity building in planning infrastructures and identifying measures and actions to be adopted for setting-up integrated hubs; _x000D_
6) enhance the efficiency and environmental sustainability of freight logistics flows across the ADRION area._x000D_
_x000D_
ISTEN final output is a strategic transnational action plan for the development of an integrated hubs network at ADRION level. Regional & National Authorities, as well as freight operators and other actors involved in the logistics chain will benefit from it, and will positively affect transport efficiency and environmental sustainability at ADRION region level. _x000D_
_x000D_
ISTEN aims to:_x000D_
- analyse local bottlenecks in maritime-rail network, related to transnational corridors and ports;_x000D_
- define measures to improve rail accessibility in hinterland port context and promote modal shift to the rail transport;_x000D_
- identify guidelines to organize transnational groups of stakeholders and an ADRION network interaction.
Immersive Underwater Museum Experience for a wider inclusion

The project aims at applying on sample areas (maritime landscapes of Torre Santa Sabina, Grado, Resnik/Siculi, Caorle) a methodological and technological protocol based on research/ knowledge and development/communication of an underwater archeological site that is complex and multi-stratified, characterized by strong diversity. The project’s objective is therefore to transform the site into an underwater archaeological park (or eco-museum) through innovative and/or experimental methodologies and techniques in order to try to reduce the loss of important cultural heritages as well as to guarantee an economic spin-off deriving directly from the creation of a sector linked to the tourist-cultural promotion of the context of reference.
A New Framework for Configuration Management and Compliance Checking for Component-Based Software Development

Component-based software development (CBSD) decreases the time and cost for developing high quality software. However, with CBSD, the maintenance of the software is more difficult, as the whole system consists of several composite components. In this paper, a three-layer framework is proposed toward designing an efficiently configurable component-based system. We also developed an algorithm to identify the primitive and composite components that are related in terms of dependency. This helps managing multiple versions of a system. A smart meter system is considered as a case study. Our algorithm is executed on this component-based system using the semantic effect annotations of Business Process Modeling Notation (BPMN) to validate the results of our algorithm. The success reflects the effectiveness of the proposed algorithm toward identifying the components affected by a change in a simple way.
Sostenere la crescita di Jaroslav Cankař e figlio di ATMOS II

L'obiettivo del progetto è sostenere l'esportazione e la presentazione di uno dei maggiori produttori europei di caldaie a combustibile solido. L'attività principale del progetto consiste nel sostenere la partecipazione del richiedente a fiere commerciali estere al fine di presentare i propri prodotti, stabilire nuovi contatti commerciali e trovare nuovi sbocchi per i suoi prodotti. La produzione del richiedente è specifica ed è necessaria una presentazione con contatto personale per le future nuove attività. Oltre ai vantaggi economici, il progetto fornirà anche benefici non economici.
Reconsidering macro-artefacts in SETI searches

Abstract The observation of macro-artefacts at interstellar distances offers an alternative search paradigm to SETI programs such as radio astronomy and laser detection. Potential artefacts range from space infrastructure deployed by advanced technological civilizations to deliberate attempts to use artefacts as signals and biomarkers of intelligent life. Passive observations of macro-artefacts could overcome problems with active transmission messaging such as temporal and spatial constraints. Artefacts could be detected without being spatially resolved by telescopes. Spectral analyses could yield evidence of disruption of the natural electromagnetic spectra of stars by artefacts. Some artefacts could generate diffraction and interference patterns uncharacteristic of natural phenomena. Thus, detecting macro-artefacts is potentially feasible with current astronomical infrastructure. The construction of large macro-artefacts could be achieved with technological and industrial capabilities that are roughly equivalent to present-day Earth. Thus, the accessibility of macro-artefacts for both transmission and reception can be reconsidered as potentially equivalent to conventional SETI strategies.
Study on environmental and genomewide predictors of early structural brain alterations in young students

Mounting evidence suggests that early life factors have an important impact on the occurrence of late-life neurological diseases. From a public health perspective this is of particular relevance for dementia, the prevalence of which is increasing drastically, with no available preventive treatment, and epidemiological data suggesting that pathological processes may begin many years before clinical diagnosis. MRI-defined structural brain phenotypes are powerful intermediate markers for dementia, and can already show measurable alterations in young and middle-aged adults. These include global and regional brain volumes, gray matter volume and cortical thickness, and markers of white matter integrity. The SEGWAY project aims to: (i) explore the heritability and genetic determinants of structural brain phenotypes in young adults in their early twenties participating in the i-Share study, the largest ongoing student cohort; (ii) take a lifetime perspective by examining the shared genetic contribution to structural brain alterations in young adulthood (i-Share) and late-life, among participants of a large French population-based study (3C-Dijon); (iii) explore the interaction between genetic variants and vascular risk factors with established impact on structural brain phenotypes, in both age groups; (iv) examine the clinical significance of genetic risk variants for structural brain alterations by testing their association with cognitive performance in young and older adults. Replication and of our findings will be sought in the multigenerational Framingham Heart Study and other independent samples. Identifying common biological mechanisms underlying both early and late-life structural brain changes would provide important information on the mechanisms and timecourse of brain aging throughout a lifetime and could be of major importance for identifying of molecular drug targets and characterizing high risk populations most likely to benefit from early interventions.
20 The Dialectics of Diaspora in Contemporary Modernity

Dwelling far from one's homeland is a frequently re-occurring Ur-Geschichte in stories of the Bible. In Jewish history, it constitutes what scholars of literature would call a leitmotiv . A Diaspora-Jewish attitude comprises a basic distrust of power-holders, aimed principally, if not necessarily directly, at concrete contemporary rulers. This chapter elaborates on a contra-factual hypothesis, asking what would have happened to Jewry had the Jews not been forced into repeated diasporas and remained a tribe in Judean desert. The chapter attempts to figure out how Diaspora Jewry and Israel in a not too distant future might come to develop and relate to each other. This may be summarized in the following three points: In the Diaspora, Judaism will increasingly evolve towards a vague ethno-culturalism; In Israel, Judaism will become increasingly terrestrially focused; The two entities of world Jewry will increasingly grow apart, but remain a reciprocal heartache for each of them. Keywords: contra-factual hypothesis; Diaspora-Jewish attitude; ethno-culturalism; Judaism; leitmotiv ; stories of Bible; world Jewry
The effect of plant population densities on growth, yield and yield components of two spring rapeseed cultivars

Rapeseed (Brassica napus L.) is an important alternate oilseed crop in eastern Anatolia, Turkey. No information on plant density for rapeseed is available in this region. Therefore a&amp;nbsp;study was initiated to investigate the effects of spacings between rows and spacings within rows on the yield and agronomic characteristics of two genotypes of spring rapeseed (Tower and Lirawell) in Erzurum, eastern Anatolia, during 1994 and 1995. The effects of spacings between or within rows on the yield and yield components of Tower and Lirawell, two cultivars of Brassica napus L., were studied for 2&amp;nbsp;years inErzurum,Turkey. Rows were spaced at 15, 30 and45 cm. Spacings within rows were 5, 10 and15 cm. The results of this study suggested that seed yield was significantly affected by spacings between rows but not by spacings within rows, and that rape yields were higher at the narrow (15 cm) row spacing compared to the middle (30 cm) and wider (45 cm) spacings.
Inp on sin photonic integrated circuits realized through wafer-scale micro-transfer printing

INSPIRE aims to revolutionize photonic integrated circuit technology by combining two technologies, InP photonics and SiN photonics, in a single platform through wafer-scale micro-transfer printing technology. This platform will allow to combine high-performance III-V opto-electronic components (semiconductor optical amplifiers, high-speed phase modulators and photodetectors) operating in the C-band with the high-performance passive functionality of the SiN platform (high performance filters, 5dB/m waveguide loss), on 200mm wafers. The micro-transfer printing integration approach enables high-throughput integration of III-V devices on SiN photonic integrated circuits with better than 1 um alignment accuracy, resulting in high-performance, low-cost photonic integrated circuits. While being applicable in a wide range of mega-markets, the INSPIRE technology will be validated by three use cases: the case of a distributed fiber sensing readout unit based, the case of a microwave photonics RF pulse generator and a datacenter switch fabric. Compact models of the III-V opto-electronic components will be developed enabling designers to exploit this platform for a wide range of applications. INSPIRE will sustain Europe’s industrial leadership in photonics by combining the generic integrated foundry technology at the pioneering pure-play foundry SmartPhotonics, and the silicon photonics pioneer IMEC, with the micro-transfer printing technology at X-Celeprint, making this a world-first platform combining the strengths of all known PIC manufacturing platforms. It will also strengthen the European manufacturing base by developing and implementing processing steps that are key to removing expensive assembly steps in photonic IC based product realization. The methods will be developed for silicon nitride – indium phosphide integration. Since the optical coupling happens through a silicon intermediate layer the developed technology can be ported to silicon CMOS photonics as well.