SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Cellsbox: a modular system for automated cell imaging experiments

Based on research from ERC CoG HydroSync where we developed both hardware and software approaches to cell imaging, we are in the position to develop translationally a cell culture and imaging unit, with integrated modular hardware and analysis software allowing automated robust performance. This promises to not just significantly bring down the costs for a broad spectrum of cell biology and single cell imaging experiments. It will also make these experiments more reproducible, systematic and easily accessible in standardised fashion. Perhaps most important of all, by designing in an integrated (whilst modular architecture) system all the components of the experiment (optics, mechanics, cell environment and fluids control, cell sample chambers, analysis), we make it possible to rapidly feedback information on the state of the sample into actions by any of the other modules, thus allowing a new space of experimental design.  This automation in running the experimental stage of cell biology, microbiology, infectious disease models, early embryo developmental work, etc (i.e. any of the many situations where one aims to follow the properties of individual cells) also aligns to the current revolution triggered by machine and deep learning approaches. We can imagine a day when integrated experimental ""CellsBoxes"" perform, in a hypothesis-driven optimised and tireless fashion, a battery of experiments that today would simply be inconceivable.   This project addresses one of the experimental bottlenecks that still make too much of biological and medical research subject to bias and poor reproducibility, and change the nature of point-of-care cell tissue analysis. It will be disruptive in the current landscape of optical cell imaging, a market > $1bn globally.
Supportive international approach to increase and improve the mobility and exchange

Project in brief _x000D_
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Although the Mediterranean territories have any cultural and economic similarities, there is a gap in the mobility of students and professionals compared to other areas of the world with less comparable features. The gap is even wider when looking at the intensity of mobility of young people within European Union. Specific EU funded initiatives, such as ERASMUS and Leonardo da Vinci, have demonstrated to be powerful means to boost the mobility of young people eventually leading to the mobility of workers. MED-MOBIL intends to extend this experience to the Mediterranean area by creating a framework of cooperation which facilitates the exchange of students, professionals and young entrepreneurs. Support to future regulations and improvement of existing mobility programmes will also be addressed by the project. _x000D_
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Specific objectives _x000D_
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To create a framework of cooperation to support future regulations and improve/consolidate programmes and initiatives aiming to facilitate the exchange of students, professionals and young entrepreneurs in the Mediterranean
Post-hazard labor wage fluctuations: a comparative empirical analysis among different sub-sectors of the U.S. construction sector

Purpose The primary objectives of this study are to (1) highlight subsectors and industry groups of the construction sector that are most vulnerable to weather-related disasters (with highest labor cost escalation) and (2) analyze how immediate this labor wage escalation happens in different subsector of the construction sector. Design/methodology/approach The research methodology consists of three steps: (i) integrating various data sources to enable measurement of the county-level labor wage changes following large-scale weather-related disasters; (ii) measuring postdisaster labor wage changes at the county level; and (iii) comparing amount and timing of postdisaster labor wage changes among all sub-sectors (and industry groups) of the construction sector. Findings The results show that among the three construction subsectors (Heavy and Civil Engineering Construction subsector, Construction of Buildings subsector, and Specialty Trade Contractors sub-sector), Heavy and Civil Engineering Construction subsector is the most vulnerable to weather-related disasters. The industry groups under the Heavy and Civil Engineering Construction subsector showed the same vulnerability level; however, under the Construction of Buildings subsector, Industrial Building Construction industry group showed to be the most vulnerable; and under the Specialty Trade Contractors subsector, the Building Foundation and Exterior Contractors industry group is the most vulnerable. The results also showed that in approximately 75% of the damaged counties, there were increases in wages of all construction labors, over the following three quarter after the disasters. In average, labor wages in Construction of Buildings subsector and the Specialty Trade Contractors subsector decreased by 0.6% and 0.8%, respectively, in the quarter of disaster and gradually increased by 4.4% and 4.6%, respectively, in the following three quarters. On the other hand, Heavy and Civil Engineering Construction’s labor wages did not experience this decrease right after the disasters; wages increased immediately after disasters hit the counties and continually increased by 8.6% in three quarters after the disasters. It is expected that the results of this study will help policy makers, cost estimators and insurers to have a better understanding of the post-disaster construction labor wage fluctuations. Originality/value This study is unique in the way it used construction labor wage data. All data are location quotient, which makes the comparison among the affected counties (with different construction size) feasible.
Ceratopsia increase: history and trends

The taxonomic history of the Ceratopsia began in 1876 with the description of Monoclonius crassus Cope followed in 1889 by Triceratops horridus Marsh. After a peak of discovery and description in the 1910s and 1920s resulting from the Canadian dinosaur rush in the province of Alberta and the Central Asiatic Expeditions to Mongolia of the American Museum of Natural History, the study of ceratopsians declined to a low level until the 1990s, when discoveries in China, Montana, Utah, Alberta, and elsewhere, abetted by increased biostratigraphic and phylogenetic precision, led to an unprecedented resurgence of activity. Even Richard C. Fox, along with colleagues from Peking University, joined in the activity, by naming Psittacosaurus lujiatunensis. To place the activity in historical perspective, half of all known ceratopsians have been described since 2003. Despite important finds of basal ceratopsians in China, Mongolia, and Korea, North America continues to dominate ceratopsian, especially ceratopsid, diversity.
Measuring the effectiveness of error messages designed for novice programmers

Good error messages are critical for novice programmers. Re-cognizing this, the DrRacket programming environment provides a series of pedagogically-inspired language subsets with error messages customized to each subset. We apply human-factors research methods to explore the effectiveness of these messages. Unlike existing work in this area, we study messages at a fine-grained level by analyzing the edits students make in response to various classes of errors. We present a rubric (which is not language specific) to evaluate student responses, apply it to a course-worth of student lab work, and describe what we have learned about using the rubric effectively. We also discuss some concrete observations on the effectiveness of these messages.
Subcortical contributions to effective connectivity in brain networks supporting imitation

Using functional magnetic resonance imaging (fMRI), we investigated effective connectivity in brain networks supporting imitation. Despite extensive reports of regional functional specialization underlying action perception, action execution and imitation, our understanding of the potential contribution of subcortical sites is limited, as is our knowledge of how regions displaying functional specialization interact with each other on a system level. While in the scanner, participants performed a simple imitation paradigm with three conditions: Observe trials, in which participants passively viewed a human actor executing a sequence of four finger presses on a keypad; Imitate trials, in which participants imitated the actor's finger presses on a keyboard; and Execute trials, in which participants also executed finger presses but did so based on visuospatial cues in the absence of the actor's hand. Relative to the Execute condition, Imitate trials evoked significantly more activity in superior and inferior parietal lobules (SPL, IPL), posterior superior temporal sulcus (pSTS), and in a ventral aspect of dorsal premotor cortex (PMd). Psychophysiological interaction (PPI) analysis, a means of assessing effective connectivity, revealed significant interactions with regions of cerebellar lobule VII from seeds both in the right pSTS and right SPL, such that activity in these sites was more highly correlated during imitation. A similar interaction was found between right pSTS and left IPL. These results clarify the role of cortical regions supporting action observation, action execution and imitation, and highlight the role the cerebellum may play in facilitating both motor and nonmotor aspects of imitation.
Targeting Hedgehog signaling pathway and autophagy overcomes drug resistance of BCR-ABL-positive chronic myeloid leukemia

The frontline tyrosine kinase inhibitor (TKI) imatinib has revolutionized the treatment of patients with chronic myeloid leukemia (CML). However, drug resistance is the major clinical challenge in the treatment of CML. The Hedgehog (Hh) signaling pathway and autophagy are both related to tumorigenesis, cancer therapy, and drug resistance. This study was conducted to explore whether the Hh pathway could regulate autophagy in CML cells and whether simultaneously regulating the Hh pathway and autophagy could induce cell death of drug-sensitive or -resistant BCR-ABL(+) CML cells. Our results indicated that pharmacological or genetic inhibition of Hh pathway could markedly induce autophagy in BCR-ABL(+) CML cells. Autophagic inhibitors or ATG5 and ATG7 silencing could significantly enhance CML cell death induced by Hh pathway suppression. Based on the above findings, our study demonstrated that simultaneously inhibiting the Hh pathway and autophagy could markedly reduce cell viability and induce apoptosis of imatinib-sensitive or -resistant BCR-ABL(+) cells. Moreover, this combination had little cytotoxicity in human peripheral blood mononuclear cells (PBMCs). Furthermore, this combined strategy was related to PARP cleavage, CASP3 and CASP9 cleavage, and inhibition of the BCR-ABL oncoprotein. In conclusion, this study indicated that simultaneously inhibiting the Hh pathway and autophagy could potently kill imatinib-sensitive or -resistant BCR-ABL(+) cells, providing a novel concept that simultaneously inhibiting the Hh pathway and autophagy might be a potent new strategy to overcome CML drug resistance.
Providing  key account management  services for the sme instrument beneficiaries and enhancing innovation management capacity services to lithuanian smes in 2017-2018

The overall aim of SME Coach LT 2017 is to increase effectiveness and efficiency of investment in R&D and Innovation by enhancing innovation management capacity of Lithuanian SMEs -beneficiaries of the new dedicated SME instrument under Horizon 2020, and SMEs with significant innovation activities and a high potential for internationalization. 
Specifically, the project will support SMEs - beneficiaries of the SME instrument- in identifying project-specific barriers and weaknesses and gaps in their innovation capacities that hinder realization of growth opportunities, and pointing to suitable coaches to address the identified weaknesses. The Key Account Manager will support SMEs SME Instrument beneficiaries in identifying critical issues and gaps with regards to their innovation idea and guide them to relevant lead coach who will support the company throughout their innovation journey. The Key account Manager will use a holistic and dynamic business innovation model, supported by Business Innovation Roadmap Tool, available under Creative Commons License from smE-MPOWER network.
The second specific objective is supporting  SMEs with significant innovation activities and a high potential internationalization in enhancing their innovation management capacities. When supporting companies having innovation and internationalization potential, but not part of SME instrument, we will use IMP3rove Academy’s diagnostic tool which measures the performance of the company’s innovation management system. However taking into account the SME context, we intend to use action- based (and case-driven) learning approach to addressing identified gaps in the innovation system. smE-MPOWER tools can support the coaching process.
WET SHEET FLEXIBLE PACKAGE AND LABEL FOR THE WET SHEET FLEXIBLE PACKAGE

A flexible wet-sheet package (1) which comprises wet sheets (2) impregnated with a liquid, a flexible film bag (3) in which the wet sheets (2) are packaged and which has a sheet takeout opening (31), and a label (5) with which the sheet takeout opening (31) is covered and which is separably adherent to a surface of the film bag (3). Upon peeling the label (5) off the film bag (3), the sheet takeout opening (31) becomes open and a pressure-sensitive adhesive layer (53) is exposed in an area which is in the surface of the film bag (3) and surrounds the sheet takeout opening (31). A substrate (54) is interposed between the pressure-sensitive adhesive layer (53) and the surface of the film bag (3). The substrate (54) is made of a film having higher compression strength than the film constituting the film bag (3).
Intossicazione da monossido di carbonio

Il monossido di carbonio (CO) è la principale causa di intossicazione accidentale in Francia. La sua incidenza è in calo in parte grazie all’attuazione di un sistema di sorveglianza e di prevenzione fornite rispettivamente dall’Institut de veille sanitaire (InVS) e dall’Institut national de prévention et d’éducation pour la santé (INPES). Gli effetti deleteri del CO sono legati a una tossicità immediata da ipossia cellulare con blocco della catena mitocondriale che può provocare coma e fallimento cardiovascolare e a una tossicità ritardata da perossidazione dei componenti della mielina attraverso l’attivazione piastrinica e dei leucociti polinucleati con conseguenti danni cerebrali. Il trattamento si basa sull’ossigenoterapia normobarica (ONB). Le indicazioni della gestione mediante ossigenoterapia iperbarica (OIB) sono riservate a casi ben definiti: perdita di coscienza prima o al momento del trattamento, insufficienza d’organo (neurologica, respiratoria o cardiovascolare) e donna in gravidanza. In seguito all’intossicazione da CO, è necessario un follow-up medico per rilevare eventuali disturbi neuropsichici e valutarne l’impatto sulla vita quotidiana. La potenziale gravità delle intossicazioni così come delle sequele scatenate giustifica la creazione del rilevatore di CO portatile.
GNSS/INS/On-board Camera Integration for Vehicle Self-Localization in Urban Canyon

This paper presents a precise vehicle self-localization system for autonomous driving. The developed system integrates multiple on-board passive sensors, Global Navigation Satellite System (GNSS), Inertial Navigation system (INS) and on-board monocular camera, in order to achieve lane-level localization performance in urban environment. GNSS based positioning technique suffers from the effects of multipath and Non-Line-Of-Sight (NLOS) propagation in urban canyon. The positioning error also affects the performance in the integrated GNSS/INS system. In the other side, the lane-marking on road surface provides the important visual source of information for driving. This paper proposes to detect the occupied lane of vehicle using on-board cameras. The lane detection result is integrated with GNSS/INS system in order to improve the positioning error. The experiment results demonstrate that the proposed method can provide 90% correctness with respect to the occupied lane.
Federated cps digital innovation hubs for the smart anything everywhere initiative

The overall ambition of the FED4SAE innovation action (IA) is to boost and sustain the digitization of the European industry by strengthening competitiveness in Cyber Physical Systems (CPS) and embedded system markets. In alignment with the ""Smart Anything Everywhere"" initiative goals, FED4SAE will:
- Create a pan-European network of Digital Innovation Hubs (DIH) by leveraging existing regional ecosystems across full value chains and a range of competencies. DIHs will enable both tech and non-tech innovative Third parties (Startups SMEs, Midcaps) from any sector to build new products and services with “digital inside”.
- Act as a European added-value one-stop-shop to facilitate innovators-suppliers cross-border partnerships which will accelerate innovation in products and processes of European Third parties by providing technical, industrial and innovation management expertise. This will lead to quantifiable increases in market shares, productivity, industrial capacities of the Third parties, and a broader adoption of CPS and embedded systems solutions.
- Link innovators to investors associated to DIHs to reach out to further funding opportunities and enable the next steps of the Third parties’ developments after completing their application experiments (AEs).
- Ensure the self-sustainability of the DIHs pan-European network by developing cooperation with regional organizations and key stakeholders engaging public and or private investment to fund FED4SAE network activities.
FED4SAE is built upon the key learnings obtained in the EuroCPS, Gateone-project, CPSE Labs IAs. FED4SAE will leverage the best practices related to Third party engagement, submission, evaluation and selection of AEs. FED4SAE will give birth to a competitive ecosystem where European Startups, SMEs and Midcaps will thrive as they access to leading technology sources, competencies and industrial platforms and also to well-connected business infrastructures and existing regional innovation hubs.
Biomacromolecules from municipal solid bio-waste fractions and fish waste for high added value applications.

Municipal solids waste (MSW) are collected by municipalities and represents more than 500 kg/capita (EU-27 average), 300 million tonnes overall every year in the EU-32. Currently, approximately 50% of this volume is landfilled. More than 1.3 million tonnes of Marine rest raw material (MRRM) are generated in Europe each year.  Some countries, such as Norway and Denmark, have traditionally for animal feed. It will therefore be a challenge for the industry to develop methods to turn fish viscera and skin, currently considered as undesirable raw materials for hydrolysis and human consumption, into profitable products.  
DAFIA will exploit MSW and MRRM as feedstocks for high value products. The parallel exploitation of the two feedstocks may create synergies. This expertise will be utilised in process development from MSW, while at the same time, new added-value products may be identified from both feed stocks.
The main objective of the DAFIA project is to explore the conversion routes of municipal solid waste (MSW), and marine rest raw-materials (MRRM) from the fish processing industries, to obtain high added value products, i.e. flame retardants, edible/barrier coatings and chemical building blocks (dicarboxylic acids and diamine) to produce polyamides and polyesters for a wide range industrial applications. 
Different value-chains and products will be selected and explored based on the potential commercial value and the technical feasibility including new microbial strains and processes for conversion of major feedstock fractions, enzymatic and chemical modifications of components isolated from the feedstock or produced in microbial processes.
Up to four cost-effective molecule groups suitable for the final selected applications will be targeted (nucleic acids, dicarboxylic acids, diamines and gelatine), & two value-chains (MSW & MRRM) will be evaluated at pilot scale to reach TRL5.
Visible light-mediated copper photoredox-catalyzed ring-opening transformations of activated small ring aza-heterocycles and carbacycles

PhotoCuRiOT is envisaged and designed to develop novel synthetic tactics to biologically significant cyclic and acyclic nitrogenous organic compounds via visible light-mediated Cu(I)-based photoredox catalyst-assisted ring-opening transformation of small ring aza-heterocycles and aminocarbacycles. Considering the earth abundance and low cost, Cu(I)-based complexes, especially copper(I) phenanthroline derivatives, are recently being used as efficient photocatalysts and as low-cost alternative to the Ru or Ir-based complexes. A range of Cu(I)-complexes will be screened for optimizing the efficiency of the aforementioned ring-opening transformation processes. The most effective catalyst will oxidatively activate the substrates and the reactions will proceed through the generation of photoinduced reactive species (primarily amino radical cations) that can be productively harnessed for the synthesis of a range of high-value functional motifs after successive ring opening and annulation with suitably functionalized nucleophiles. PhotoCuRiOT will address the long-standing problem of finding an appropriate classical activation mode for different varieties of small ring aza-heterocycles (non-activated and activated) by offering a unique generic activation mode through the formation of amino radical cationic intermediates. PhotoCuRiOT also aims to bridge the gap between the fields of medicine and energy by enabling facile and highly selective synthesis of a wide array of high value heterocyclic moieties by utilizing copper complexes as environmentally benign photoredox catalysts and visible light as a sustainable source of energy. The successful photoactivation and subsequent ring-opening/expansion transformations of azacyclopropanes and azacyclobutanes would also allow late stage functionalizations of many drugs based on these heterocyclic skeletons such as ciprofloxacin which is a widely-prescribed cyclopropylamine-containing antibiotic.