SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Working Process Simulation Analysis on an Diesel Injector with Different Needle Valve Parameters

The injector is a key component of the diesel fuel oil injection system, which directly affects the performance of the diesel engine. And the needle valve is a vital part for the injector. In order to analyze the effect of the needle valve parameters on injection performance, the simulation model of a certain type diesel injector was established based on AMESim. And a simulation for a whole injection cycle of this injector was performed, thus the injection characteristics and the relevant information about motion of the needle valve was obtained. The effect on the velocity of the needle valve, the flow rate and the quantity of the fuel oil injection, etc. had been analyzed by changing the needle valve parameters such as the preload of the pressure regulating spring, the needle valve diameter, and the orifice diameter. The analysis would provide some references in structure design, optimization, test data analysis and fault diagnosis.
Ansell Portugal: Augmentation de la capacité pour la production de solutions avancées de protection industrielle

Le projet vise à doter l’entreprise des technologies les plus avancées, le résultat de R&D interne qui, permettant une augmentation de capacité de 66 % de son établissement, permet la production de gants neufs et avancés, avec un seul niveau d’adhérence (50 % plus élevé), et une réponse proactive au marché.
ASSOCIATION BETWEEN POSITIVE CANINE HEARTWORM (<i>DIROFILARIA IMMITIS</i>) ANTIGEN RESULTS AND PRESENCE OF<i>ACANTHOCHEILONEMA ODENDHALI</i>MICROFILARIA IN CALIFORNIA SEA LIONS (<i>ZALOPHUS CALIFORNIANUS</i>)

This study establishes a relationship between positive canine heartworm (Dirofilaria immitis) test results frequently observed in California sea lions (Zalophus californianus) and infection with the filarid nematode Acanthocheilonema odendhali. Four commercially available canine heartworm antigen tests were evaluated for cross-reaction with A. odendhali in California sea lions. Sera were tested from fifteen California sea lions with A. odendhali-associated microfilaremia, confirmed by blood smear, and with no evidence of D. immitis infection at necropsy. Ninety-five percent of tests were falsely positive for D. immitis. This study also determined that the prevalence of A. odendhali infection in stranded California sea lions from central California is approximately 23% by comparing the number of findings of mircofilaremia to the total number of California sea lions sampled at The Marine Mammal Center between 2005 and 2011, inclusive. Acanthocheilonema odenhali microfilaremia in California sea lions is likely to cross-react with canine heartworm antigen tests, and clinicians should interpret results with caution.
Selective fabrication of carbon nanowires, carbon nanotubes, and graphene by catalytic chemical liquid deposition

Abstract Large quantities of graphene sheets, carbon nanotubes, and ultra-long carbon nanowires can be selectively fabricated at a high rate in ethanol by catalytic chemical liquid deposition under atmospheric pressure at room temperature. Synthesis of the carbon nanostructures can be achieved through the following procedural changes: (a) by manipulating the H 2 O content, carbon nanostructures can be tailored from carbon nanotubes (CNTs) with various inner diameters to carbon nanowires (CNWs). (b) By adding an organic precursor containing S, graphene can be selectively fabricated. The simplicity and scalability of our method provides a high potential for mass growth, and the inherent cleanliness of the procedure offers a perfect starting point for straightforward, contamination-free synthetic processes without the use of expensive equipment. We also provide clear pictures of the growth process of these materials, where the pressure difference across the graphene surface results in the formation of bubbles that leads to the growth of CNTs, CNWs, or graphene.
Abstract LB-315: Suppression of tumor invasion and metastasis by inhibition of c-MET and VEGF signaling together

Treatment with inhibitors that block vascular endothelial growth factor (VEGF) signaling can make tumors more aggressive in preclinical models. The mechanism underlying this form of resistance is not fully understood, but vascular pruning, intratumoral hypoxia, and increased expression of c-MET, the tyrosine kinase receptor for hepatocyte growth factor (HGF), could be contributing factors. We found that treatment of pancreatic neuroendocrine tumors in RIP-Tag2 mice with a neutralizing anti-VEGF antibody or with sunitinib, a receptor tyrosine kinase inhibitor that blocks VEGFR and related receptors, reduced tumor burden and vascularity but increased intratumoral hypoxia, HIF-1alpha, and expression and activation of c-MET. Invasion into the exocrine pancreas and metastasis to the liver also increased. Importantly, administration of either of two c-MET inhibitors, PF-04217903 or crizotinib (PF-02341066), together with anti-VEGF therapy reduced tumor growth and vascularity and also significantly decreased local invasion and liver metastasis. Similar benefits were found after treatment with cabozantinib (XL184), a multitargeted tyrosine kinase inhibitor that simultaneously blocks c-MET and VEGF receptors. Together, these results indicate that inhibition of VEGF signaling can promote vascular pruning, intratumoral hypoxia, HIF-1alpha accumulation, and activation of c-MET. Concurrent inhibition of c-MET and VEGF signaling not only can slow tumor growth but also can reduce invasion and metastasis. Inhibition of c-MET and VEGF signaling pathways together combines the favorable tumor growth-slowing effects of inhibiting angiogenesis with suppression of invasion and metastasis, despite the intratumoral hypoxia due to vascular pruning. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr LB-315. doi:1538-7445.AM2012-LB-315
Chinese Erdheim-Chester disease: clinical-pathology-PET/CT updates

Summary Erdheim-Chester disease (ECD), one type of systemic non-Langerhans cell histiocytosis, has been rarely seen and is characterized by the accumulation of foamy CD68+CD1a- histiocytes. We reported a case of ECD and reviewed the clinical features of 13 cases of ECD reported so far in China. A 53-year-old male was diagnosed with central diabetes insipidus in March 2014, followed by fever, splenomegaly and anemia in July 2014. His initial pituitary magnetic resonance imaging (MRI) revealed the absence of high signal at T1-weighted image in posterior pituitary without any lesion. A further positron emission tomography/computer tomography (PET/CT) images showed elevated metabolic activity of 18 F-2-fluro-D-deoxy-glucose (FDG) and low 13 N-NH3 uptake in the posterior pituitary, and multi-organ involvement. Biopsy at right femur lesion revealed that granulomatous infiltration of foamy histiocytes and Touton giant cells surrounded by fibrosis tissues. Immunohistochemistry stain was positive for CD68, negative for CD207/Langerin and S-100. The diagnosis of ECD was confirmed and the treatment with pegylated interferon was effective. ECD was a possible immune-related disorder concluding from the IgG4 immunohistochemistry results. We summarized the pathological manifestations for ECD and its differential diagnosis from Langerhans cell histiocytosis (LCH) and Rosai-Dorfman disease (RDD). ECD should be considered by both pathologists and clinicians in the differential diagnosis when central diabetes insipidus is accompanied with multi-organ involvement, especially skeletal system involvement, or recurrent fever. Learning points ECD should be considered when central diabetes insipidus is accompanied with multisystem involvement, especially symmetric/asymmetric bone lesions, or recurrent fever. PET/CT scanning was helpful for locating pituitary lesion, discovering multiple system involvement and indicating the biopsy sites. Conducting proper immunohistochemistry stains was important for diagnosing ECD. ECD might be correlated with immune disorder.
An exploratory study of South African women’s experiences of In Vitro Fertilisation and Embryo Transfer (IVE-ET) at fertility clinics

Infertility is considered to be a growing problem worldwide. In sub-Saharan Africa, at least 20%-50% of couples of reproductive age experience a fertility problem and 30% are diagnosed with infertility. This study explores the experiences of women in South Africa who are involuntary childless and explores their psychological and emotional experiences of In Vitro Fertilisation and Embryo Transfer (IVF-ET). Utilising a qualitative methodology, a diverse group of 21 married women diagnosed with infertility and who had undergone at least two cycles of IVF-ET were recruited. Semi-structured, in-depth individual interviews were conducted and the data were analysed using thematic analysis. The results of the study indicated that the women perceived themselves as not conforming to a dominant belief system and as a result felt compelled to explore all the medical options available. They reported emotional turmoil characterised by primary binary emotions of anxiety-excitement and nervousness-optimistic. These emotions were experienced throughout the five stages of the IVF-ET treatment cycles. A synopsis of the psychological and emotional responses to the IVF-ET treatment is discussed. The findings of this study suggest the need for the incorporation of a mandatory psychosocial intervention as part of infertility management. Greater attention to the psychological and emotional repercussions of infertility treatment could lead to a more personalised client-approach which, in turn, would prepare infertile women and couples for the emotional demands of the treatment.
EXCHANGER BODY AND EXCHANGER

The invention relates to an exchanger body comprising: - an element wound in a spiral and consisting of two sheets of heat-conducting material which define channels for a fluid between one another, - at least one distributor, and - at least one collector.
79TiP A phase I, open-label, dose escalation, confirmation, and expansion trial of BI 1810631 as monotherapy in patients with advanced or metastatic solid tumors with HER2 aberrations

HER2 mutations are present in 2–4% of NSCLC tumors; of these ∼50% are exon 20 insertion (ex20ins) mutations. There is an unmet need for effective targeted therapy against HER2 mutations in solid tumors, particularly in NSCLC. BI 1810631 is a HER2 selective TKI that covalently binds to both wild-type/mutated HER2 receptors, including ex20ins, whilst sparing EGFR signaling; preclinical data suggest good tolerability and efficacy. This phase Ia/Ib, open-label, non-randomized study aims to determine safety, MTD, PK, pharmacodynamics, and preliminary efficacy of BI 1810631 in pts with HER2+ solid tumors (NCT04886804). ∼96 pts from 3 sites in the US, Netherlands, and Japan will be recruited. Phase Ia: consecutive cohorts of pts will receive BI 1810631 QD or BID at escalating doses. Starting dose level: 15 mg BID; QD schedule will begin after one dose level above estimated therapeutic dose of BI 1810631 is determined safe by the Dose Escalation Committee (expected starting dose: 60 mg). BI 1810631 dose escalation will continue until MTD and/or RP2D is determined, as well as preferred phase Ib schedule. Phase Ib: an initial 30 pts with HER2 ex20ins mutation-positive, pre-treated NSCLC will be enrolled, with possible inclusion of additional cohorts in the future. Inclusion criteria (Phase Ia): ≥18 years of age; histologically/cytologically confirmed HER2+ advanced, unresectable and/or metastatic solid tumors refractory/not suitable for standard therapy; exhausted treatment options; measurable or evaluable lesions (according to RECIST v1.1); ECOG PS ≤1. Phase Ib criteria: HER2 ex20ins mutation-positive NSCLC; received ≥1 line of platinum-based combination chemotherapy in the advanced/metastatic setting. Primary endpoints: MTD based on the number of DLTs/number of pts with DLTs (Phase Ia); objective response (Phase Ib). Secondary endpoints: number of pts with DLTs throughout entire treatment period and PK parameters (Phase Ia/Ib); duration of response, PFS, disease control, and duration of disease control (Phase Ib). The trial is actively recruiting; 5 pts have been enrolled to date and 2 dose levels have been completed. NCT04886804. Medical writing assistance, supported financially by Boehringer Ingelheim, was provided by Rick Burgon, of Ashfield MedComms, an Ashfield Health Company, during the development of this abstract. Boehringer Ingelheim. Boehringer Ingelheim.
Strategy with Externalities (Version 1)

The purpose of this model is to explore the effects of technological and social shifts on the behavior of incumbent and startup firms. The model was constructed to provide insight into the choices firms make regarding adoption of new energy technologies. A firm’s performance is determined by its location on an NK fitness landscape, and each firm’s strategy, or technology portfolio, is modeled as a string of bits which locate the firm on the landscape. Firms move along the landscape by modifying their strategies. The model explores how the performance landscape needs to shift in order for startups to become established and incumbents motivated to search for higher preforming strategies.

The conceptual space representing all possible firm strategies is described in terms of an NK model. Each strategy is represented as a string of N binary decisions, each of which is dependent on K other decisions within that same string. A firm's performance, or value, is represented as an average of the contributions from each decision and its related decisions. 

The model is based on two landscapes,old world and new world. To start a number of incumbent firms search for advantageous positions on the old world landscape. The landscape is then shifted and startup firms are added to the new world landscape. The two types of firms then search the new world landscape for advantageous positions.

Firms are instantiated with different levels of aspiration which are used to trigger search behaviour. If a firm’s relative performance is above their aspiration level it will not change its strategy, but when the performance drops below that threshold a firm will choose one of two search types: incremental or imitative. Each time period firms that fall below a specified relative performance are removed with a given probability.
Development of Integrated Acoustic Modifying Elements Technology

The subject of the proposed project will be the development of innovative products in the form of Integrated Acoustic Modifying Elements. These are technological solutions to ensure the best possible acoustic conditions in public buildings and collective residence without the need to replace their equipment for new or interference with the decor. These elements, mounted directly to furniture and objects located in the immediate vicinity of end users, will significantly improve acoustic comfort in their immediate surroundings. In addition, the Acoustic Modifying Elements Technology (ZAEM Technology) will be developed, which will provide knowledge about the method of arrangement of the above elements in such a way that in a modified room the improvement of acoustic conditions is as high as possible. Thanks to the development of ZAEM Technology and Integrated Acoustic Modification Elements, the Applicant will provide not only acoustic systems, but also detailed guidelines on how to deploy them. By implementing the results of the project, the company Gorycki &Sznyterman will thus respond to the needs of the market and the insatiable demand for such solutions. Reference number of the aid programme: SA.41471(2015/X) Purpose of public aid: Article 25 of EC Regulation No 651/2014 of 17 June 2014 declaring certain types of aid compatible with the internal market in the application of Articles 107 and 108 of the Treaty (OJ L. I'm sorry. EU L 187/1 of 26.06.2014).
Robust solutions to Stackelberg games: Addressing bounded rationality and limited observations in human cognition

How do we build algorithms for agent interactions with human adversaries? Stackelberg games are natural models for many important applications that involve human interaction, such as oligopolistic markets and security domains. In Stackelberg games, one player, the leader, commits to a strategy and the follower makes her decision with knowledge of the leader's commitment. Existing algorithms for Stackelberg games efficiently find optimal solutions (leader strategy), but they critically assume that the follower plays optimally. Unfortunately, in many applications, agents face human followers (adversaries) who — because of their bounded rationality and limited observation of the leader strategy — may deviate from their expected optimal response. In other words, human adversaries' decisions are biased due to their bounded rationality and limited observations. Not taking into account these likely deviations when dealing with human adversaries may cause an unacceptable degradation in the leader's reward, particularly in security applications where these algorithms have seen deployment. The objective of this paper therefore is to investigate how to build algorithms for agent interactions with human adversaries. To address this crucial problem, this paper introduces a new mixed-integer linear program (MILP) for Stackelberg games to consider human adversaries, incorporating: (i) novel anchoring theories on human perception of probability distributions and (ii) robustness approaches for MILPs to address human imprecision. Since this new approach considers human adversaries, traditional proofs of correctness or optimality are insufficient; instead, it is necessary to rely on empirical validation. To that end, this paper considers four settings based on real deployed security systems at Los Angeles International Airport (Pita et al., 2008 [35] ), and compares 6 different approaches (three based on our new approach and three previous approaches), in 4 different observability conditions, involving 218 human subjects playing 2960 games in total. The final conclusion is that a model which incorporates both the ideas of robustness and anchoring achieves statistically significant higher rewards and also maintains equivalent or faster solution speeds compared to existing approaches.
Bilistick: a low cost point-of-care for early diagnosis of hyperbilirubinemia in newborns

The objective of the overall project is to lead to the international market “Bilistick”, an innovative low-cost Point-of-Care for early diagnosis of hyperbilirubinemia. The system aims to prevent, through early diagnosis, the permanent neurological damage that severe hyperbilirubinemia can cause in newborns.Every year in European Union there are about 3 thousands cases of kernicterus (worst consequence of hyperbilirubinemia) determining consequent huge costs for National Healthcare Systems. 
Kernicterus is a largely preventable disease if severe hyperbilirubinemia is identified early and promptly treated. For this reason AAP Guidelines (adopted by EU) recommend universal bilirubin screening and individualized post-discharge follow-up care based on results of such screening. However existing solutions are expensive, not portable or not enough accurate. 
Bilistick is the only in vitro rapid diagnostic device for measuring the level of bilirubin in the blood of newborns. It is low cost, minimally invasive, portable, giving rapid response, accurate and applicable in all newborns. It is the result of experience acquired during years of academic and professional research carried out by the entrepreneurial team of Bilimetrix s.r.l.. Bilimetrix s.r.l. is a spin-off of the University of Trieste, established as a research and development company. Its core business is development of medical devices based on advanced technologies oriented on liver, kidney and heart dis-functions. All solution are mainly based on new biomarkers. 
The purpose of the feasibility study is a comprehensive examination of all aspects of feasibility of the project, from the technical to the economical viewpoint, converging in a detailed business plan for application in Phase 2. Emphasis will be put on market analysis (nature of the market, type of users, competitors in the market, pricing systems, methods of distribution and marketing) and then on  examination of the market acceptance towards Bilistick
Study of the Bulk Magnetic and Electrical Properties of MgFe&amp;lt;sub&amp;gt;2&amp;lt;/sub&amp;gt;O&amp;lt;sub&amp;gt;4&amp;lt;/sub&amp;gt; Synthesized by Chemical Method

Nanocrystalline Magnesium ferrite has been prepared by chemical co-precipitation technique. Structural characterization has been performed by X-ray diffraction. Formation of ferrites has also been studied by using FTIR. Frequency dependence of real and imaginary part of initial permeability has been presented for the samples sintered at different temperatures. Real part of initial permeability, increases with the increase of grain growth. The loss component repre- sented by imaginary part of initial permeability decreases with frequency up to the measured frequency of this study of 13 MHz. Curie temperatures have been determined from the temperature dependence of permeability. Curie temperatures for the samples of this composition do not vary significantly with the variation of sintering temperatures. B-H loop measurements have been carried out by B-H loop tracer. Transport property measurements haven been carried out by electrometer and impedance analyzer.
Multifunction device

A multifunction device to be situated within a central console of a motor vehicle has an instrument panel for receiving one or more elements (e.g., display and/or operating elements), the instrument panel being designed as movable and being transferable from a closed position into an open position, the instrument panel being situated within an opening of the central console in the closed position. Furthermore the central console has a storage element, which is situated outside the field of vision of the vehicle occupants in the closed position of the instrument panel and which is freely accessible to the vehicle occupants in the open position of the instrument pane. It is thus possible to provide a multifunction device to be situated within a central console of a motor vehicle, which is particularly easily reachable for the driver of the motor vehicle and simultaneously can increase the possible useful space within a motor vehicle.