SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
A Decline in Wnt3a Signaling is Necessary for Mesenchymal Stem Cells to Proceed to Replicative Senescence

Umbilical cord blood-derived mesenchymal stem cells are a promising source of cells for regeneration therapy due to their multipotency, high proliferative capacity, relatively noninvasive collection, and ready availability. However, extended cell culture inevitably triggers cellular senescence-the irreversible arrest of cell division-thereby limiting the proliferative lifespan of adult stem cells. Wnt/β-catenin signaling plays a functional role as a key regulator of self-renewal and differentiation in mesenchymal stem cells (MSCs), and thus Wnt/β-catenin signaling and cellular senescence might be closely connected. Here, we show that the expression levels of canonical Wnt families decrease as MSCs age during subculture. Activation of the Wnt pathway by treatment with Wnt3a-conditioned medium or glycogen synthase kinase 3β inhibitors, such as SB-216763 and 6-bromoindirubin-3'-oxime, delays the progression of cellular senescence as shown by the decrease in the senescence effectors p53 and pRb, lowered senescence-associated β-galactosidase activity, and increased telomerase activity. In contrast, suppression of the Wnt pathway by treatment with dickkopf-1 (an antagonist of the Wnt coreceptor) and β-catenin siRNA transfection promotes senescence in MSCs. Interestingly, the magnitude of the response to enhanced Wnt3a/β-catenin signaling appears to depend on the senescent state during extended culture, particularly after multiple passages. These results suggest that Wnt3a signaling might be a predominant factor that could be used to overcome senescence in long-term cultured MSCs by directly intervening in the proliferative capacity and MSC senescence. The functional role of Wnt3a/β-catenin signaling in hedging cellular senescence may allow the development of new approaches for stem cell-based therapies.
Íñigo López de Mendoza y María Rafaela Villalverche, llamada María de Mendoza: música, diplomacia y nobleza en el siglo XVI

La nómina de mujeres dedicadas de forma profesional a la música en el siglo XVI aún es bastante desconocida. Este trabajo está dedicado a Rafaela Villalverche, música y cantora, que entró a formar parte de la Casa de los Mendoza por su matrimonio con Íñigo López de Mendoza, hijo segundo del III marqués de Mondéjar. En su juventud ejerció como música profesional, primero al servicio de la marquesa de Alcañices y más tarde siendo contratada para cantar y tañer en las veladas musicales que organizaba el marqués de Priego y en otras casas señoriales como la de Benito de Cisneros o la de Pedro Zapata en Madrid. Su matrimonio se celebró sin contar con la aprobación de los marqueses de Mondéjar por la desigual condición de la joven pareja. Íñigo fue en consecuencia desheredado y apartado de la familia. Desarrolló su vida dentro del ámbito académico y como experto jurista en la Universidad de Alcalá de Henares de la que fue catedrático. Contó sin embargo con el favor de Felipe II que le eligió para una embajada en Paris, desde donde pasó a los Países Bajos como miembro del Consejo de Estado y Guerra, y después a Venecia como embajador del reino de España ante la República. María de Mendoza acompañó a su esposo en la embajada veneciana y falleció en esta ciudad poco tiempo después de llegar. Aunque nunca logró la aceptación de los Mendoza, su hijo mayor Íñigo acabó heredando el marquesado de Mondéjar tras el fallecimiento sin descendencia de Luis Hurtado de Mendoza, IV marqués de Mondéjar.
Consolidation of european research excellence in exascale hpc systems

Europe has made significant progress in becoming a leader in large parts of the HPC ecosystem: from industrial and scientific application providers via system software to Exascale systems, bringing together technical and business stakeholders. Despite such gains, excellence in research in high performance computing systems is fragmented across Europe and opportunities for synergy missed. 

At this moment, there is fierce international competition to sustain long-term leadership in HPC technology and there remains much to do. Europe intends to increase the budget spent on HPC by 1 billion euros. In order to realize the full potential of this investment, it will have to engage all the stakeholders, industrial as well as academic. EUROLAB4HPC’s bold overall goal is to build connected and sustainable leadership in high-performance computing systems by bringing together the leading performance orientated communities in Europe, working across all layers of the system stack, fuelling new industries in HPC. 

EUROLAB4HPC’s overarching goal is to Strengthen academic research excellence and innovation in HPC in Europe. This will be realised by means of four short-term objectives: (i) Structuring the community – by adding members to develop a community of excellence that engages in focussed high-quality cross-stack activity; (ii) Promoting entrepreneurship - by building an innovation pipeline from general purpose entrepreneurial training, business prototyping, business plan development and helping with funding, (iii) Stimulating technology transfer - by connecting with other technology transfer activities and providing competitive seed funding for HPC technology transfer, and (iv) Disseminating community news – by investing substantial resources in dissemination activities, creating a stronger EUROLAB brand. This will raise the visibility of the community, attract more participants and eventually grows the interest and impact of Europe’s Exascale research.
Toward an All-Around Semilocal Potential for Electronic Exchange

We test local and semilocal approximations of the exchange potential for a variety of systems including atoms, molecules, and atomic chains. In particular, we focus on a recent universal extension of the Becke−Johnson exchange potential [Rasanen, E.; Pittalis, S.; Proetto, C. R. J. Chem. Phys. 2010, 132, 044112]. It is shown that when this potential is used together with the Becke−Roussel approximation to the Slater potential [Becke, A. D.; Roussel, M. R. Phys. Rev. A 1989, 39, 3761−3767], a good overall agreement is obtained with experimental and numerically exact results for several systems, and with a moderate computational cost. Thus, this approximation is a very promising candidate in the quest for a simple and all-around semilocal potential.
Ad-Hoc Self-Organized Microgrid for Rural Electrification and Post-disaster Response

This paper presents the concept for an ad-hoc self-organized microgrid based on moveable and renewable energy sources and fully distributed coordination between intelligent power routing nodes. The primary goal of the proposed architecture is to build an adaptive, scalable, and reliable system to support energy provisioning with limited infrastructural planning. Our vision focuses on two use-case scenarios: promote electrification and energy sharing in isolated rural areas, and support emergency response crews in disaster relief situations. Both scenarios rely on the deployment of an autonomous microgrid based on movable generators and renewable sources which will dynamically reconfigure itself and adapt to changes with minimal user intervention.
CONVERTING OXYGENATES TO OLEFINS IN THE PRESENCE OF ELECTROMAGNETIC ENERGY

A process comprises contacting an oxygenate feed with a molecular sieve catalyst in the presence of an electromagnetic energy and converting the oxygenate feed to olefins.
The Meaning of Life Intervention for Patients With Advanced-Stage Cancer: Development and Pilot Study

To develop the Meaning of Life Intervention in response to the need for brief and meaning-focused interventions in palliative care and to establish potential effect sizes for future full-scale randomized, controlled trials.A randomized, controlled trial conducted to pilot test the Meaning of Life Intervention.A 68-bed oncology inpatient ward in an urban acute general hospital in Hong Kong.84 patients with advanced-stage cancer. Fifty-eight completed the study.Assessments of outcome variables were conducted at baseline and one day and two weeks after the intervention. Patients were randomly allocated to the intervention group or the control group. Repeated measures analysis of covariance were conducted to assess the impact of the Meaning of Life Intervention on participants' quality of life.The primary outcome was quality of life and was measured by the Quality-of-Life Concerns in the End-of-Life (QOLC-E) questionnaire and with a single-item scale on global quality of life. The eight subscales of the QOLC-E served as secondary outcomes.Statistically significant main effects were noted for the group in the QOLC-E questionnaire total score, the single-item scale on global quality of life, and the existential distress subscale of the QOLC-E questionnaire. The effects represented a medium effect size.The results of this pilot study show that the Meaning of Life Intervention can improve quality of life, particularly existential distress.The Meaning of Life Intervention represents a potentially effective and efficient intervention that is feasible for implementation by nursing staff for patients with advanced-stage cancer in a palliative care setting.
Las salidas de campo en la docencia de la Geografía Humana: uso de los desafíos urbanos en itinerarios didácticos co-elaborados por el alumnado

Se presenta en este texto una experiencia de innovación docente dentro de los CIMA (Ciclos de Mejora en el Aula) desarrollada en la REFID (Red de Forma- ción e Innovación Docente) de la Universidad de Sevilla durante el primer cua - trimestre del curso 2021/2022. La innovación se centró en la co-elaboración del itinerario de la salida de campo de la asignatura Geografía Humana de primero de Grado en Geografía y Gestión del Territorio. Con el alumnado como centro del aprendizaje, y a partir del planteamiento de un problema, localizaron y propu- sieron soluciones para los desafíos urbanos presentes en barrios del casco his- tórico de Sevilla. Palabras clave: Geografía humana, grado en geografía y gestión del territorio, docencia universitaria, desarrollo profesional docente, salida de campo.
SPACE-BASED OVERALL DEVELOPMENT ASSESSMENT OF REGIONAL——AS A CASE OF GUANGZHONG-TIANSHUI ECONOMIC ZONE

According to overall regional development level of evaluation system from space function,design factors affecting the overall regional development level of a comprehensive evaluation index system is established,and the content framework of multihierachy-multobjective fuzzy comprehensive measure model,and in Guanzhong-Tianshui area as the research object,this paper discusses the function of space under the influence of the development level of the whole area of comprehensive evaluation,and then put forward the whole development mechanism.Results show that under the influence of dimensional function of the index system to grasp the overall development of the area,the coordinated development between urban and rural areas and future development trend,and timely adjust regional development direction moderately,and formulates target-oriented reach certain development target,and formulate improve overall regional development level of effective ways.
The paths of international law: stability and change in the international legal order

International law erects high hurdles for change – typically unanimity or a uniformity of practice of states – and this high threshold has provoked much criticism for hindering the pursuit of justice, the provision of public goods, and the democratic revision of political choices. Yet in different areas, such as international criminal law or the law of international organizations, international law has in recent times undergone more rapid change than the traditional picture would allow, and often in informal ways that do not fit classical categories. However, this greater dynamism has found little sustained attention in scholarship so far. 

The PATHS project seeks to fill this gap and understand when and how international law changes, how this change is registered among participants in legal discourses and how the pathways of change differ across issue areas and sites of international legal practice. Drawing on scholarship in international law and international relations, it aims to trace attempts at informal change in international law in six issue areas, identify relevant factors behind the developments in those cases, and understand how they relate to the formal categories of international legal change. The project expects significant variation in the ‘paths’ of change in different contexts and issue areas, with an important role for global institutions – international organizations, courts, and expert bodies – in many of them. PATHS also seeks to assess these paths normatively: it explores what mechanisms for change would be legitimate in an international legal order that has increasingly turned from a quasi-contractual institution into a structure of governance with a far more limited role for state consent than in the past.
 
With this focus on change, PATHS aims to make a major contribution to our understanding of international law, its political dynamics, as well as its normative grounding in a globalised world.
VARIABLE SPEED HYDRAULIC PUMP

The invention provides a variable speed hydraulic pump designed to operate at a maximum horsepower throughout its pressure range by adjusting motor speed according to motor load parameters. In particular, the variable speed hydraulic pump includes a hydraulic pump unit coupled to a variable speed electric motor by a drive unit and to a hydraulic fluid tank for pressurizing and pumping hydraulic fluid when operated by the motor. A motor controller is electrically connected to the motor to supply drive signals to the motor based on electrical characteristics of the drive signals which are dependent on the load exerted on the motor. Suction from the load is provided by both the main pump and a bidirectional supercharging pump by reversing the direction of the motor and shifting a 4/3 valve to connect the main pump inlet to the load and its outlet to tank. In addition, the controller reduces the motor speed at the maximum rated pressure to just maintain the pressure, to reduce the amount of fluid pumped through the maximum pressure relief valve.
Apc/C substrates: how are they disengaged from their non-degraded binding partners?

The anaphase promoting complex/ cyclosome (APC/C) is an E3 ubiquitin ligase that controls the cell division cycle by targeting main cell cycle regulators for proteasomal degradation, thereby ensuring error-free cell division and safeguarding genome stability. Its foremost activity is during cell division, or mitosis, when two sets of sister chromatids are equally divided over two newly formed daughter cells.
Intriguingly, APC/C substrates that are degraded at the metaphase-to-anaphase transition have binding partners, which are not degraded. It remains a mystery how the APC/C controls degradation of the substrates and leaves the binding partners undisturbed. My objective is to clarify the molecular mechanism of substrate-binding partner disengagement, and determine the impact of disengagement on substrate degradation, to ensure controlled sister chromatid separation and genome integrity. First, I propose to identify the precise timing of disengagement during the process of ubiquitination, at the molecular level: this will give fundamental insight into disengagement control (Objective 1). Next, I will study ubiquitination at the proteomics level, by unraveling how Lysine-choice, and ubiquitin chain topology affect disengagement (Objective 2). Finally, I will combine conventional molecular biology methods with advanced microscopy techniques to investigate the importance of controlled substrate-binding partner disengagement for substrate degradation and genome stability (Objective 3).
I will employ a multi-disciplinary approach, combining molecular biology, proteomics, and in vivo cell biology approaches to resolve this fundamental biological question. The identified mechanism may provide insights into ternary complex formation of the APC/C and its substrates, which will enable translation to develop targeted-protein-degradation drugs.
SYSTEMS AND METHODS FOR DETERMINING A REGION IN AN IMAGE

A method for determining a region of an image is described. The method includes presenting an image of a scene including one or more objects. The method also includes receiving an input selecting a single point on the image corresponding to a target object. The method further includes obtaining a motion mask based on the image. The motion mask indicates a local motion section and a global motion section of the image. The method further includes determining a region in the image based on the selected point and the motion mask.
Impacts of off-fault plasticity on fault slip and interaction at the base of the seismogenic zone

Direct observations of faults exhumed from mid-crustal depths indicate that distributed inelastic deformation enhances fault slip and interaction across steps. Constrained by field measurements, finite element models demonstrate that the slip distribution for a fault in a Mises elastoplastic continuum differs significantly from that of a linear elastic model fault. Lobes of plastic shear strain align with fault tips and effectively lengthen the fault, resulting in greater maximum slip and increased slip gradients near fault tips. Additionally, distributed plastic shear strain facilitates slip transfer between echelon fault segments. Fault arrays separated by contractional steps, which are subjected to greater mean normal stress and Mises equivalent stress, produce greater maximum slip than do those separated by extensional steps (with no fractures). These results provide insight into fault behavior at the base of the seismogenic zone, with implications for rupture dynamics of discontinuous faults.
Implementazione di innovazioni nella stampa digitale su vetro

Il progetto "Attuazione dell'innovazione nella stampa digitale su vetro" consiste nell'acquisto di un nuovo supporto durevole necessario per implementare l'innovazione di processo consistente nella stampa ceramica di elementi in vetro. La struttura del progetto separa un compito che comporta l'acquisto di una nuova attività fissa. Il progetto sarà attuato tra il 1º febbraio 2023 e il 31 dicembre 2023. L'obiettivo del progetto è quello di rafforzare la competitività di Glass Sp. z o.o. implementando l'innovazione di processo, che contraddistingue l'offerta dell'azienda su scala nazionale e quindi migliora la posizione competitiva dell'azienda. Ciò è in linea con l'obiettivo specifico dell'azione II.3 "Rafforzare la competitività delle PMI" del POR LO per il periodo 2014-2020. L'innovazione di processo risponde alla domanda dei clienti e ai risultati dell'analisi delle tendenze del mercato. Il progetto sarà attuato nel comune di Zgierz, per il quale il tasso di imprenditorialità è di 115,27, pari al 100,75 % della media del voivodato (secondo i dati forniti nella documentazione del concorso).
Modelling the koi herpesvirus (KHV) epidemic highlights the importance of active surveillance within a national control policy

Summary
1. Koi herpesvirus can cause serious disease in carp Cyprinus carpio populations globally. Populations of carp exposed to the virus are already widespread across England and Wales, and there is a need to determine whether and how to control its spread. This study evaluates potential management options and provides recommendations applicable to many infected countries.

2. The influences of the main drivers of the epidemic were investigated using simple compartment based models, and the effectiveness of several potential control options were evaluated. Models were parameterized using recorded fish movement, field and experimental data.

3. Experimental studies suggested the risk of transmitting the virus between waters on angling equipment was low. Data from previous studies suggested live fish movements between fisheries, and the introduction of imported ornamental fish to be the most likely routes by which a fishery could be infected.

4. The models suggest that fish movements between fisheries alone could not have led to the number of exposed sites known to exist in 2007. An additional external infection pressure such as the introduction of imported ornamental fish would have been required, and is likely to have been the main driver of the epidemic in its early stages.

5. Predictions of future scenarios suggest that fish movements between fisheries have taken over as the main driver of the epidemic, and consequently restricting imports to reduce the external infection pressure is unlikely to have much impact on its own.

6. Due to the small proportion of infected waters currently detected, increasing the duration of movement restrictions placed on infected sites from four years to permanent was predicted to have little effect on the epidemic.

7. Synthesis and applications. Given the current stage of the koi herpesvirus epidemic, reducing the spread of the virus between fisheries is likely to be challenging, but may be possible by conducting an active surveillance programme and placing permanent movement restrictions on exposed sites. However, this will only be effective if the external infection pressure can also be reduced, possibly through restrictions on the import of fish from koi herpesvirus infected countries.
MULTI-LAYER CHEMICAL AND BIOLOGICAL PROTECTION FABRIC FOR MOBILE SHELTERS

A lightweight, low bulk, mobile CB shelter fabric includes a high tensile strength woven scrim laminated between two thin CB-impenetrable polymer films. Laminate adhesives can include isocyanate adhesion promotors. Coatings can be applied to the films for camouflage, increased light opacity, increased CB protection, sun, fire, and weather resistance. Lamination heat and pressure can cause the films to conform and bond through the scrim, while a pre- applied coating does not flow and remains uniform in thickness. The resulting fabric weight can be approximately 50% of conventional CB fabrics. The films can be hard-drawn polymers. A coating of hammer milled kaolin clay can provide increased light opacity. The films can be 1 micron thick, and can be nylon, aliphatic nylon, urethane, or poly-ether. The scrim can be a 1500 denier vectran with a 4.5 ends-per-inch warp and a 3.5 ends-per-inch fill. The scrim yarns can be flattened bundles of untwisted fiber.
Comparison of two multiaxial fatigue models applied to dental implants

This paper presents two multiaxial fatigue life prediction models applied to a commercial dental implant. One model is called Variable Initiation Length Model and takes into account both the crack initiation and propagation phases. The second model combines the Theory of Critical Distance with a critical plane damage model to characterise the initiation and initial propagation of micro/meso cracks in the material. This paper discusses which material properties are necessary for the implementation of these models and how to obtain them in the laboratory from simple test specimens. It also describes the FE models developed for the stress/strain and stress intensity factor characterisation in the implant. The results of applying both life prediction models are compared with experimental results arising from the application of ISO-14801 standard to a commercial dental implant