SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
INTERACT PRO MONTE

The "Interact Pro Monte" project is share in two main phases.
A first phase of evaluation of best practices of cross border, transnational and interregional cooperation in mountain sustainable development. These informations would be analysed and adapted to expectations of mountain local authorities and development actors.
During the second phase, the transfer and the diffusion would be doned towards plateforms of targeted public and to regional and local authorities and development actors of mountain areas.
One of the main aims of the "Interact Pro Monte" project is to analyse what kind of cooperation projects are done in mountain and what difficulties are met by the local and regional authorities, by public and private development actors.
The Interact Pro Monte project could strongly contribute to EU policies, national and regional policies concerning mountain sustainable development.
Entwicklung des Betriebsumfelds der Region Juvan Vehmaa

Ziel des Projektes ist es, das Betriebsklima der Region Juva Vehmaa umfassend zu entwickeln und dabei unterschiedliche Methoden zu nutzen, von der Datenerfassung über die Aktivierung der Zusammenarbeit zwischen Unternehmen bis hin zur Intensivierung des Betriebs. Maßnahmen: das Projekt wird zunächst durch das Sammeln von Bodendaten aufgebaut, die mit den Bemühungen um die Entwicklung des tatsächlichen Betriebsumfelds beginnen werden, darunter eine aktivere Zusammenarbeit zwischen Unternehmen vom Marketing bis zur Identifizierung neuer Unternehmen. . Ergebnisse: Deutliche Intensivierung der Zusammenarbeit zwischen Unternehmen in einer Reihe von Sektoren sowie das Wachstum der Region durch neue Unternehmen, wodurch der Kundenfluss und die Chancen für Unternehmen, einen besseren Umsatz zu erzielen, erhöht werden;
Structural and Histochemical Changes in Rat Parietal Cortex Neurons during Biliary Drainage

The aim of the study reported here was to assess structural and metabolic changes in rat parietal cortex neurons during complete external bile drainage. Quantitative histochemical and electron microscopic methods were used. The findings showed that drainage of bile from the body led to gradual increases in the numbers of hyperchromic pyknotic neurons and ghost cells, death and reductions in the numbers of neurons, and increases in the number of glial cells in all layers of the parietal cortex. There was a gradual decrease in neuron size, with loss of sphericity (elongation). The cytoplasm showed decreases in succinate dehydrogenase, NADH, NADPH, and glucose-6-phosphate dehydrogenases, and decreases in RNA content, though these changes were accompanied by activation of lactate dehydrogenase and acid phosphatase. Nuclei and organelles (mitochondria, endoplasmic reticulum, Golgi complexes) underwent destructive changes, which were accompanied by increase in the numbers and sizes of lysosomes and phagosomes. Some neurons showed activation of the nuclear apparatus and increases in the relative content of free ribosomes. Thus, loss of bile from the body induced progressive increases in structural and metabolic changes in parietal cortex neurons, leading to the death of some and compensatory changes in others.
Decision and approximation complexity for identifying codes and locating-dominating sets in restricted graph classes

An identifying code is a subset of vertices of a graph with the property that each vertex is uniquely determined (identified) by its nonempty neighbourhood within the identifying code. When only vertices out of the code are asked to be identified, we get the related concept of a locating-dominating set. These notions are closely related to a number of similar and well-studied concepts such as the one of a test cover. In this paper, we study the decision problems Identifying Code and Locating-Dominating Set (which consist in deciding whether a given graph admits an identifying code or a locating-dominating set, respectively, with a given size) and their minimization variants Minimum Identifying Code and Minimum Locating-Dominating Set . These problems are known to be NP -hard, even when the input graph belongs to a number of specific graph classes such as planar bipartite graphs. Moreover, it is known that they are approximable within a logarithmic factor, but hard to approximate within any sub-logarithmic factor. We extend the latter result to the case where the input graph is bipartite, split or co-bipartite: both problems remain hard in these cases. Among other results, we also show that for bipartite graphs of bounded maximum degree (at least 3), the two problems are hard to approximate within some constant factor, a question which was open. We summarize all known results in the area, and we compare them to the ones for the related problem Dominating Set . In particular, our work exhibits important graph classes for which Dominating Set is efficiently solvable, but Identifying Code and Locating-Dominating Set are hard (whereas in all previous works, their complexity was the same). We also introduce graph classes for which the converse holds, and for which the complexities of Identifying Code and Locating-Dominating Set differ.
Natural and experimental evolution of sexual conflict within Caenorhabditis nematodes

Although males and females need one another in order to reproduce, they often have different reproductive interests, which can lead to conflict between the sexes. The intensity and frequency of male-male competition for fertilization opportunities is thought to be an important contributor to this conflict. The nematode genus Caenorhabditis provides an opportunity to test this hypothesis because the frequency of males varies widely among species with different mating systems.We find evidence that there is strong inter- and intra-sexual conflict within C. remanei, a dioecious species composed of equal frequencies of males and females. In particular, some C. remanei males greatly reduce female lifespan following mating, and their sperm have a strong competitive advantage over the sperm of other males. In contrast, our results suggest that both types of conflict have been greatly reduced within C. elegans, which is an androdioecious species that is composed of self-fertilizing hermaphrodites and rare males. Using experimental evolution in mutant C. elegans populations in which sperm production is blocked in hermaphrodites (effectively converting them to females), we find that the consequences of sexual conflict observed within C. remanei evolve rapidly within C. elegans populations experiencing high levels of male-male competition.Together, these complementary data sets support the hypothesis that the intensity of intersexual conflict varies with the intensity of competition among males, and that male-induced collateral damage to mates can evolve very rapidly within populations.
Parasite communities of two three-spined stickleback populations in subarctic Norway—effects of a small spatial-scale host introduction

Co-introduction and colonization of parasites with the introduction of new host species into aquatic habitats may depend on the host specificity and dispersal capabilities of the parasites. We compared the metazoan parasite community of an introduced three-spined stickleback (Gasterosteus aculeatus) population with that of the nearby source population in subarctic Norway. As expected from a small spatial scale (5 km), the parasite component communities in the two lakes were highly similar. All identifiable allogenic parasite taxa (Diphyllobothrium dendriticum, Diphyllobothrium ditremum, Diphyllobothrium spp., Schistocephalus solidus, Apatemon sp. and Diplostomum spp.) were also observed in both lakes while inter-lake differences were driven by autogenic parasite taxa (Eubothrium spp., Crepidostomum spp., Nematoda spp., Proteocephalus sp. and Gyrodactylus arcuatus). Contrary to expectation, the total number of parasite taxa was higher in the introduced stickleback population (12) compared to that found in the source population (9) with three parasite taxa (Eubothrium spp., Crepidostomum spp., Nematoda spp.) only occurring in the introduced population. These parasites were uncommon however and normally restricted to salmonids. Sticklebacks from both populations were heavily infected, particularly with eye-infecting metacercariae. Sequences from the DNA barcode region of cytochrome oxidase 1 indicated that these include Diplostomum lineage 6, a member of the Diplostomum baeri complex and a member of the Strigeinae. Despite high similarity between the two component communities, quantitative inter-lake differences were found at the infracommunity level. At this scale, parasite intensity was significantly higher in the source population for the two autogenic stickleback specialists: G. arcuatus and Proteocephalus sp., assumed to be the autogenic stickleback specialist Proteocephalus filicollis. Parasite infracommunities within each lake also resembled each other significantly more than infracommunities between lakes, primarily driven by the allogenic cestode D. ditremum, as well as G. arcuatus and Proteocephalus sp. Overall, quantitative dissimilarities between the two parasite communities were possibly explained by inter-lake differences in the density of sticklebacks and intermediate hosts.
At therapeutic concentration bupivacaine causes neuromuscular blockade and enhances rocuronium-induced blockade

Partially paralyzed patients may be placed in the risk of pharyngeal dysfunction. Bupivacaine acts as acetylcholine receptor ion channel blocker and may synergistically interact with rocuronium to augment NM blockade. Thus, this study aims to elucidate whether or not, at a therapeutic concentration, bupivacaine by itself may cause NM blockade and reduce an effective concentration of rocuronium.Twenty-two left phrenic nerve-hemidiaphragms (Male SD rats, 150-250 g) were hung in Krebs solution. Three consecutive ST, 0.1 Hz and one TT, 50 Hz for 1.9 s were obtained before drug application and at each new drug concentration. A concentration of bupivacaine in Krebs solution (n = 5) was cumulatively increased by way of 0.01, 0.1, 1, (1, 2, 3, 4, 5, 6, 7) × 10 µM. In a Krebs solution, pre-treated with bupivacaine 0 (n = 5), 0.1 (n = 5), 1.0 (n = 5), 10 (n = 2) µM, and then concentrations of rocuronium were cumulatively increased by way of 1, 3, 5, 7, 9, 12, 14, 16, 18, 20 µM. EC for each experiment were determined by a probit. The EC(50)'s of rocuronium were compared using a Student's t-test with Bonferroni's correction. Differences were considered significant when P < 0.05.The potency of bupivacaine for normalized TF was 11.4 (± 1.1) µM. Below 30 µM of bupivacaine, the single twitch potentiation sustained despite the development of tetanic fade and partial inhibition of PTT. Bupivacaine significantly facilitated the NM blockade induced by rocuronium.Clinicians should be aware that bupivacaine by itself at its therapeutic concentration inhibit NM conduction and enhances rocuronium-induced muscle relaxation.
PROCESS FOR REDUCING THE PATULIN CONCENTRATION IN FRUIT JUICES

A procedure for reducing the patulin content in a fruit juice which includes presenting the juice to a resin material having in abundance micropores of less than 20 ANGSTROM minimun pore width and at least a pore surface capable of retaining patulin by the forces of chemisorption. Preferably the resin has weak base functionality and is substantially devoid of mesopores and macropores. The resin preferably has a surface area of greater than 900 m<2>/g (BET) and the resin has been hypercross-linked whilst in the swollen state. Regeneration involves the conversion of the resin held patulin to a more easily flushed out derivative using ammonia or a volatile base, preferably generated in situ from a high pH solution.
Documentation, Training and Transfer of Knowledge for Civil Protection

The project TASK FORCE aims at improving the effectiveness with which civil protection is delivered, both in preventive and reactive terms, through: • Networking, exchange of know-how and best practices • Raising Awareness on civil protection via education campaigns and the internet • Training and capacity building • Development and pilot application of a civil protection school education programme • Design and development of a Web-site for the project and the monitoring of civil protection issues in the Archimed area As civil protection mechanisms are primarily aimed at functioning on a national level, a recent EU communication has highlighted the need for more training and better communication and coordination between national agencies. As ARCHIMED areas share similar threats, the scope of this project is to bring together experience in dealing with similar civil protection situations, thus creating significant multiplier effects on project outcomes.
Pretreatment of cylindrical coconut activated carbon and performance as catalyst support

Cylindrical coconut activated carbon(CCAC) support was graphitized at a high temperature(1900 °C) in argon, then oxidized with an O2-N2-H2O mixture, and treated with nitric acid. Pretreatment of carbon support on its mechanical strength, physical structure, chemical composition and surface properties of cylindrical CCAC support was investigated by X-ray diffraction(XRD), surface area analysis, scanning electron microscopy(SEM), energy dispersive spectroscopy(EDS), thermogravimetric-differential thermogravimetric(TG-DTG) analysis and temperature programmed desorption-mass spectrometry(TPD-MS), and the effect of CCAC support on the catalytic activities was also studied. The results show that the degree of graphitization, the purity(phosphorus, sulphur), pore structure(micropore, mesopore) and oxygen-containing functional groups(—COOH, —OH, —COOR) of carbon supports are obviously different, which have a great influence on the performance of Ru-based catalysts. After a series of pretreatments, the surface physical and chemical properties of the commercial CCAC are modified and improved, and the activity of as-prepared Ru/AC catalyst is increased significantly.
Clinical validation of trop-2 as a serum biomarker for monitoring of disease-course in patients affected by breast and colon cancer

A critical need in cancer care is the possibility to monitor tumour progression, through non-invasive techniques, to recognize relapses and/or metastases at a very early stage. The measurement of tumour biomarkers circulating into the bloodstream is a feasible way, as it can give indications also on patients’ response to therapeutic treatments, thus enabling the oncologist to pursue a precision-medicine strategy. In patients affected by breast and colon cancer, most serum biomarkers employed in the clinical practice have poor specificity and sensitivity to be used as monitoring tool of the cancer progression. Oncoxx Biotech has collected strong experimental data demonstrating that the transmembrane receptor Trop-2 drives progression of several tumour types. It has also been shown that Trop-2 is a determinant of breast cancer survival, and it is released in the bloodstream in patients with breast and colorectal cancer. In this respect, the results achieved in a preliminary clinical study have shown that all higher-than-baseline levels of circulating Trop-2 identify breast cancers with 100% specificity and 80% sensitivity and colon cancer with 100% of specificity and 74% of sensitivity. Therefore, scope of the ThruBlood project is to validate Trop-2 as a serum biomarker for monitoring disease-course in patients with breast and colon cancer. During Phase 1 we will: 1) assess the scientific feasibility of the proposed biomarker by extending the population of serum samples to analyse; 2) design the Clinical Validation Study to pursue in Phase2; 3) validate a standardized procedure for accurate measurement of the serum Trop-2 levels using a proprietary device (ICONA, patented by the applicant) with aim of providing high-throughput procedures for serum biomarker detection; 4) analyse and validate the business opportunity represented by the introduction of the ThruBlood assay in the current procedure adopted for surveillance of cancer diagnosed and treated patients.
Study of somesthesis according to change in pulse diode laser parameters

Laser can precisely deliver quantitative energy to a desired region in a non-contact way. Since it can stimulate regions and minutely control parameters such as the intensity, duration and frequency of stimulus, laser is often used for the areas such as low power laser treatment and clinical physiology. This study proposes simulation using pulse diode laser with reliable output and identifies laser parameters that can present a variety of somesthesis. It is found that typically, as frequency and energy increase, the ratio of feeling senses increases, and dominant sense moves from the sense of heat through tactile sense to pain. This study will be baseline data for studies of the sense of heat, tactile sense and pain, contribute to studying neurophysiology sector and be applied to basic clinical research.
UV-TRANSMISSIVE FABRIC, METHOD OF OBTAINING THE SAME AND GARMENT BEING MADE OF THE SAID FABRIC

The invention pertains to a fabric comprising a first yarn having a UV-A transmission of between 10 and 50 % while substantially blocking UV-B transmission, and at least a second yarn different from the first yarn, the yarns being interweaved such that the fabric has regular mesh openings that give rise to a transmission of the fabric of between 20 and 65 % for UV-A and between 3 and 20 % for UV-B. The invention also pertains to a method of making such a fabric and a garment being made using such a fabric.
Primary symptomatic adrenal insufficiency induced by megestrol acetate.

Megestrol acetate (MA) is a progestational agent for the treatment of metastatic breast cancer and endometrial cancer. MA has also been used to promote weight gain in malnourished elderly patients, in patients with immunodeficiency virus and in cancer-induced cachexia. In addition to thromboembolic disease, MA may induce hyperglycaemia, osteoporosis, suppression of the gonadal axis, and Cushing's syndrome. MA has also been shown to cause symptomatic suppression of the hypothalamic-pituitary-adrenal (HPA) axis owing to its intrinsic glucocorticoid-like effect. Three additional patients are presented who developed symptomatic adrenal insufficiency while they were receiving 160-320 mg MA daily. The patients were treated with cortisone acetate supplements, had clear evidence of HPA-axis suppression but recovered fully after MA was discontinued. Patients receiving MA might have an inadequate adrenal response during stressful conditions, possibly because 160-320 mg MA daily may not provide adequate protection to prevent the symptoms of adrenal insufficiency. The adverse MA effect on the HPA axis is probably not well recognised in clinical practice, and clinicians need an increased awareness of the endocrine complications secondary to MA treatment.
Empirical parametrization of the two-photon-exchange effect contributions to the electron-proton elastic scattering cross section

The most recent electron-proton elastic scattering data were re-analyzed using an empirical parametrization of the two-photon-exchange (TPE) effect contributions to ${\ensuremath{\sigma}}_{R}$. The TPE effect contribution $F({Q}^{2},\ensuremath{\varepsilon})$ was double Taylor series expanded as a polynomial of order $n$ keeping only terms linear in $\ensuremath{\varepsilon}$ to account for the experimentally observed and verified linearity of the Rosenbluth plots. We fix the ratio $R={G}_{\mathit{Ep}}/{G}_{\mathit{Mp}}$ to be that obtained from a fit to the recoil-polarization data and parametrize ${\ensuremath{\sigma}}_{R}$ first by a three-parameter formula (fit I) and then by a two-parameter formula (fit III). In contrast to previous analyses, the fit parameter ${G}_{\mathit{Mp}}^{2}$ as obtained from these fits is either smaller or equal to the values obtained from our conventional Rosenbluth fit (fit II) but never larger. The ratio $g({Q}^{2})/{G}_{\mathit{Mp}}^{2}$ which represents the ratio of the TPE and one-photon-exchange (OPE) effect contributions to the intercept of ${\ensuremath{\sigma}}_{R}$ is large and it ranges 3%$\ensuremath{-}$88%. The ratio ${R}_{1\ensuremath{\gamma}\ensuremath{\bigotimes}2\ensuremath{\gamma}}=\ensuremath{\tau}f({Q}^{2})/{G}_{\mathit{Ep}}^{2}$ which represents the ratio of the TPE and OPE effect contributions to the slope of ${\ensuremath{\sigma}}_{R}$ is also large, reaching a value of 12.0$\ensuremath{-}$14.4 at ${Q}^{2}=$ 5.25 (GeV/c)${}^{2}$. The ratio ${R}_{1\ensuremath{\gamma}\ensuremath{\bigotimes}2\ensuremath{\gamma}}$ as obtained from fits I and III is consistent, within error, with those obtained from previous analyses. Our formulas seem to explain the linearity of ${\ensuremath{\sigma}}_{R}$. Moreover, our analysis shows that the extracted ${G}_{\mathit{Ep}}^{2}$ and ${G}_{\mathit{Mp}}^{2}$ using the conventional Rosenbluth separation method can in fact be broken into the usual OPE and TPE contributions. Therefore, ${\ensuremath{\sigma}}_{R}$ can in fact be derived under weaker conditions than those imposed by the Born approximation. Our results show that the TPE amplitudes, $g({Q}^{2})/{G}_{\mathit{Mp}}^{2}$ and $f({Q}^{2})/{G}_{\mathit{Mp}}^{2}$, are sizable and grow with ${Q}^{2}$ value up to ${Q}^{2}~$ 6 (GeV/c)${}^{2}$ in agreement with previous studies. A revision of and comparison to previous analyses are also presented.
Effects of long-term proBNP cardiac gene delivery in experimental hypertensive heart disease

Results In SHR, a single systemic administration of AAV9 vector allowed longterm, cardiac BNP overexpression with an increase in plasma BNP levels as compared with untreated SHR (433.3±17 vs 60.6±15* pg/ml). This further resulted in reductions in systolic (121±11 vs 184 ±13* mm Hg) and diastolic (103±5 vs 148±24* mm Hg) BP for nine months after injection as compared with untreated SHR. Left ventricular (LV) thickness (1.87±0.1 vs 2.16±0.3* mm), LV end-systolic dimensions (3.96±0.3 vs 4.66±0.6* mm) and LV mass (0.4±0.01 vs 0.49±0.01* gr) were reduced, while ejection fraction was increased (83±2 vs 74±4* %) in BNP-treated compared to untreated SHR. Circumferential systolic strain (-5.04±0.4 vs -3.74 ±0.4* %) and strain rate of the early phase of diastole (-4.57±2.1 vs -2.41±1.3 1/s) were improved in BNP-treated compared with controls. Importantly, the improvement in cardiac function and structure also resulted in a significant increase in survival (p<0.001 vs untreated SHR). Non-cardiac overexpression of BNP, via AAV2 vector, was not associated with changes in plasma BNP and BP in SHR. Nevertheless, normotensive Wistar rats injected with AAV9 proBNP vector showed significantly reduced heart/body weights (0.31± 0.1 vs 3.9±0.1* %) four weeks after injection without BP reduction compared to untreated rats.