SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Fluticasone furoate and vilanterol inhalation powder for the treatment of chronic obstructive pulmonary disease

Fluticasone furoate/vilanterol (FF/VI) is a novel inhaled corticosteroid/long-acting β₂-agonist (ICS/LABA) fixed dose combination that, by simplifying the dosing schedule, allows, for the first time in a member of the ICS/LABA class, a shift from twice-daily to once-daily treatment. FF/VI is delivered via a novel, single-step activation, multi-dose dry powder inhaler for oral inhalation, Ellipta. Regrettably, there are no head-to-head trials that have shown superiority in the safety or efficacy of FF versus other ICSs, but evidence shows that VI has a quicker onset of effect versus salmeterol. However, the clinical utility of this effect in a maintenance medication is still questionable. Furthermore, benefits of FF/VI over twice-daily ICS/LABA comparator have not been shown yet and, in addition, its adverse event profile is generally consistent with the known class effects of an ICS/LABA fixed dose combination. In particular, there is an increase in the risk of pneumonia among patients treated with FF/VI relative to VI, mainly among those who benefit most from FF/VI. Nevertheless, the interesting pharmacological profiles of both FF and VI, the possibility that FF/VI can be administered once-daily, and the attractive characteristics of Ellipta are important features that could help FF/VI to be a successful combination in the treatment of chronic obstructive pulmonary disease.
Development of Normal-Suction Boundary Control Method Based on Inflow Cannula Pressure Waveform for the Undulation Pump Ventricular Assist Device

It is desirable to obtain the maximum assist without suction in ventricular assist devices (VADs). However, high driving power of a VAD may cause severe ventricle suction that can induce arrhythmia, hemolysis, and pump damage. In this report, an appropriate VAD driving level that maximizes the assist effect without severe systolic suction was explored. The target driving level was set at the boundary between low driving power without suction and high driving power with frequent suction. In the boundary range, intermittent mild suction may occur. Driving power was regulated by the suction occurrence. The normal-suction boundary control method was evaluated in a female goat implanted with an undulation pump ventricular assist device (UPVAD). The UPVAD was driven in a semipulsatile mode with heartbeat synchronization control. Systolic driving power was adjusted using a normal-suction boundary control method developed for this study. We confirmed that driving power could be maintained in the boundary range. Occurrences of suction were evaluated using the suction ratio. We defined this ratio as the number of suction occurrences divided by the number of heartbeats. The suction ratio decreased by 70% when the normal-suction boundary control method was used.
Interdisciplinary training network for validation of gram-negative antibacterial targets

Antimicrobial resistance is posing a continuously-rising threat to global health. Indeed, one key recommendation from the recent “Action plan against the rising threats from Antimicrobial Resistance” report (submitted by the Commission to the European Parliament and Council (15.11.2011)) is the development of effective antimicrobials or alternatives for treatment of human and animal infections.  The INTEGRATE project is a direct response to this. We have assembled a team of 10 beneficiaries from eight EU member states, encompassing both academic and non-academic sectors and different disciplines, to form a consortium committed to training Early Stage Researchers (ESRs) in the discovery and preclinical validation of novel Gram-negative antibacterial agents and antibacterial targets. The principle aim of the consortium is to provide a training platform where students are exposed to every aspect of the antimicrobial discovery process, ranging from target identification and validation, through organic synthesis, in silico design and compound screening, to mode-of-action and possible resistance mechanisms. This exposure will be accomplished through a concrete secondment plan, coupled with a series of high-level consortium-wide training events and networking programmes. Our intention is to reverse the current fragmentation of approaches towards antibacterial discovery through mutual cooperation. The INTEGRATE training framework is built on an innovative research project aimed at targeting important but non-essential gene products as an effective means of reducing bacterial fitness, thereby facilitating clearance of the pathogen by the host immune system. To achieve this, the individual work programmes have been designed to seamlessly inter-mesh contributions from the fields of in silico design, organic synthesis, molecular biology and biochemistry, and the very latest in vitro and in vivo screening technologies.
Good riddance 2016

It is the year of new beginnings - of Iluka Resources beginning to work in Sierra Leone, after the Sierra Rutile merger completes; of, potentially, the creation of a refractories behemoth following the RHI/Magnesita merger; of Tesla's Gigafactory gloriously ramping up production; and of what many hope will be the slow creep back upwards for oil prices following OPEC's promise to cut oil output for the first time in almost a decade.

High purity quartz (HPQ) is another mineral market which has an upwards trajectory. The solar industry has played a big part in HPQ demand in the last decade and its role is set to grow as new large and innovative solar investments are announced. US electric vehicle maker, Tesla Motors Inc., in 2016 announced its intention to acquire Californian solar energy producer, SolarCity Corp., for $2.6bn. The cost of installing solar is also going down. Anglo-Australian mining giant, BHP Billiton Ltd, recently stated that, average, wind and solar energy are expected to reach cost-parity with incumbent technologies on a new-build, unsubsidised basis in about a decade.
A review of toxicity testing protocols and endpoints with Artemia spp.

Abstract Artemia spp. is an historically popular biological model still requiring an official internationally based standardization. Several endpoints are currently available. Short-term acute endpoints include biomarker (acetylcholinesterase; heat stress proteins; lipid peroxidation; thiobarbituric acid reactive substances; thioredoxin reductase; glutathione-peroxidase; glutathione S -transferase; glutathione reductase; aldehyde dehydrogenase; and adenylpyrophosphatase and Fluotox), hatching (dry biomass, morphological disorders and size), behavioral (swimming speed and path length), teratogenicity (growth), and immobilization (meaning mortality after 5–30 s observation). Long-term chronic tests focus on growth, reproduction and survival or mortality after 7–28 d exposure from larval to adulthood stage. We analyzed each test looking at its endpoint, toxicant and experimental design including replicates, exposure time, number of exposed cysts or organisms and their relative life stage, exposure conditions during hatching and testing (salinity, pH, light intensity, aeration dilution media, and food supply), type of testing chambers, and quality assurance and quality control criteria. Similarities and differences between the identified approaches were highlighted. Results evidenced that hatching 24 h short-term and 14 d long-term mortality are the most promising Artemia spp. protocols that should go forward with international standardization.
PortusPark Going Global

The PortusPark Going Global project, promoted by Portuspark, aims at the international promotion of associated companies, focusing on three focuses Prospection, Capacity Building and Promotion in order to promote and empower a change in mentality and the existing paradigm, directing and encouraging companies towards internationalisation, in order to increase their competitiveness and promote their added value.
Triphenyl methane compounds or analogues thereof where one or more of the phenyl groups is substituted and the tertiary carbon atom is replaced for sickle cell disease,

The triphenylmethane compound has the formula (A) or a pharmaceutically acceptable salt or hydrate thereof wherein n is 0 to 4; R1 is -H, -OR, -SR, -CN, -C(O)R, -C(S)R, -C(O)OR, -C(S)OR, -C(O)SR, -C(S)SR, -C(O)NR2, -C(S)NR2, -CH[C(O)R]2, -CH[C(S)R]2, -CH[C(O)OR]2, -CH[C(S)OR]2, -CH[C(O)SR]2 or -CH[C(S)SR]2; R2 is F, Cl, Br or I; R3 is R, OR or SR; R4 is H or NR2; R4' is H, F, Cl, Br or I and each R is H, alkyl, alkenyl, alkynyl or alkoxy with the proviso that (i) when n is 0 and R1 is H or OH, R2 is Cl, R4 = R4' then R3 is other than H and (ii) when n is 0 and R1 is H, R2 is Cl, R4 = R4' then R3 is other than OH. The triphenylmethane compound has the formula (B) or a pharmaceutically acceptable salt or hydrate thereof wherein n is 0 to 4; R1 is NR2, C(O)R, -C(S)R, -C(O)NR'2 or -C(S)NR'2; R2 is F, Cl, Br or I; R3 is F, Cl, Br or I; R4 is F, Cl, Br or I and each R and R' are independently H, alkyl, alkenyl, alkynyl or alkoxy. The triphenylmethane compound can also has the formula (C) or a pharmaceutically acceptable salt or hydrate thereof wherein n is 0 to 4; Ar1 is phenyl or cyclohexyl; R1 is NR2, -C(O)NR2, -C(S)NR2, -CH[C(O)OR]2, -CH[C(S)OR]2, -CH[C(O)SR]2 or -CH[C(S)SR]2 and each R is H, alkyl, alkenyl, alkynyl or alkoxy; with the proviso that when R1 is NH2 or -C(O)NH2, n is 1, 2 or 3. A pharmaceutical composition thereof useful for: a) inhibiting calcium-activated potassium transport of a cell, b) reducing sickle erythrocyte dehydration or delaying the occurrence of erythrocyte sickling or deformation, c) treating or preventing sickle cell disease or d) for inhibiting mammalian cell proliferation.
WALKER, Sheila S. Conhecimento desde dentro: os afro-sul-americanos falam de seus povos e suas histórias / Sheila S. Walker (Org.). Tradução Viviane Conceição Antunes. Rio de Janeiro: Kitabu, 2018.

Resenha
Steam infeed for a steam turbine

The steam supply unit (11) has an outer pipeline (14) arranged around an inner pipeline (12), where a coolant inlet opening (17) is provided for supplying a coolant i.e. live stream, between the inner pipeline and the outer pipeline. Two components (23, 24) exhibit respective inner pipelines (26, 28) and respective outer pipelines (27, 29), where the outer pipeline (14) is formed from the outer pipelines (27, 29) and the inner pipeline (12) is formed from the inner pipelines (26, 28). The inner pipeline (12) and the outer pipeline (14) are formed in a material single-piece manner.
Marine Protected Areas and Artisan Fishing Integrated Management through environmental awareness and education

The AMPPA project aims to create a new management tool for Marine Protected Areas (MPA), in consideration of the crucial role for the protection of the marine environment and for the sustainable development of coastal and marine areas, as the driving forces of the integration between resource protection needs and development needs of coastal communities. The tool proposed by the project is an integrated management of MPAs that directly involves all operators (public bodies, anglers, citizens, tourists, etc.) also through awareness-raising and environmental education actions. AMPPA proposes a correct management of the marine protected areas concerned through: 
1) Raising awareness and environmental education of operators and users; 
2) The implementation and adaptation of a method of Evaluation of the Effectiveness of Management that will result in the drafting of the "Implementing regulation and organization of the MPA", aimed at regulating in detail the activities allowed within the MPA
Noblesse, éthique et gouvernance chez les officiers locaux du roi. Bailes et alcaides dans le royaume de Valence (env. 1500-1560)1

Cet article étudie le travail des bailes et des alcaides, représentants du roi dans les villes royales et les cités du royaume de Valence, et leurs relations avec les autorités municipales. Plus précisément, les valeurs et les attitudes avec lesquelles ces fonctionnaires royaux comprenaient leurs devoirs, liés à l’éthique aristocratique, sont analysées et comparées à celles du gouvernement municipal, aux racines républicaines.
Optimization of laser micromachining process for biomedical device fabrication

Laser machining is commonly used for fabrication of medical devices with microscale features, including vascular stents, drug delivery devices, and scaffolds for tissue engineering with controlled pore size and porosity. The process can also be used to produce structured scaffolds for controlling cell growth, orientation, and location. Moreover, lasers may be used to fabricate complex channel nets in which cells are subsequently seeded or to pattern channels for microfluidic devices. Traditionally, these micro devices were fabricated using silicon substrates, but recently the use of titanium allowed to produce more robust devices at a reasonable cost. In particular, the high quality surfaces that can be obtained with laser machining reduce the liquid flow turbulence and avoid micro cavities formation, critical for bacteria proliferation. The present research reports the results of an investigation on the process capability of laser ablation to produce micro pockets fabricated on titanium sheet (0.5 mm thick). A first experimental campaign was designed for identifying a set of laser ablation cycles able to realize the micro pockets by changing the process parameters as scanning speed, laser power, q-switch frequency, loop number, and duty cycle. Moreover, a process optimization was executed in order to produce the pockets with a highly flat surface. The results were acquired by a confocal laser scanning microscope (CLSM) to obtain high-resolution images with depth selectivity and were analyzed with statistic methods for the identification of the best parameter configuration.
Coupled snakelets for curled text-line segmentation from warped document images

Camera-captured, warped document images usually contain curled text-lines because of distortions caused by camera perspective view and page curl. Warped document images can be transformed into planar document images for improving optical character recognition accuracy and human readability using monocular dewarping techniques. Curled text-lines segmentation is a crucial initial step for most of the monocular dewarping techniques. Existing curled text-line segmentation approaches are sensitive to geometric and perspective distortions. In this paper, we introduce a novel curled text-line segmentation algorithm by adapting active contour (snake). Our algorithm performs text-line segmentation by estimating pairs of x-line and baseline. It estimates a local pair of x-line and baseline on each connected component by jointly tracing top and bottom points of neighboring connected components, and finally each group of overlapping pairs is considered as a segmented text-line. Our algorithm has achieved curled text-line segmentation accuracy of above 95% on the DFKI-I (CBDAR 2007 dewarping contest) dataset, which is significantly better than previously reported results on this dataset.
Zinc oxide-praseodymia semiconducting varistors having a powerful surge suppression capability

Abstract We introduced the varistor having more powerful surge suppression capability. This research focuses on the effect of sintering time on electrical properties and pulse current degradation of Pr/Co/Cr/Y/Mg co-doped zinc oxide varistors for surge suppression. With increasing sintering time, the breakdown field decreased from 2768 to 1680 V/cm, and the nonlinear coefficient decreased from 57.7 to 29.3. Considering pulse current, a higher nonlinear coefficient led to the lower clamp voltage ratio. Therefore, the sample sintered for 1 h exhibited the best clamp characteristics, in which the clamp voltage ratio was in the range of K = 1.52–1.77 for pulse currents of 1–10 A and K = 2.04–3.43 for pulse currents of 400–2500 A. Considering pulse absorption capability, the sample sintered for 3 h exhibited the strongest electrical stability; − 3.9% in ∆ E 1 m A / c m 2  /  E 1 m A / c m 2 and − 6.9% ∆α1 / α1 after application of a pulse current of 2500 A.
RECTANGULAR (INCLUDING) MANUFACTURES

SET UP A COMPREHENSIVE PRODUCTION AND E-COMMERCE PROCESS OF VERY HIGH QUALITY TEXTURES FOR APPLICATIONS IN THE FOLLOWING FIELDS: ARCHITECTURE, DESIGN, 3D GRAPHICS AND FOR INNOVATIVE APPLICATIONS IN THE FIELD OF THE MANAGEMENT OF CULTURAL GOODS.
Industrial Heritage in Granada and Almería - The Recovery of the Zurgena Railway Station as an Example of the Reinterpretation of the Lorca-Baza Railway Line

In this paper we present the history of an old railway line in Andalucía: the Lorca - Baza railway line. In the paper we recall the beginning and development, the rise and fall of the British company that kept the line alive from the late nineteenth century until the Spanish Civil War, and the exploitation by RENFE until 1984. The railway line was of enormous importance in the transport of iron ore and goods from Andalusia to the port of Águilas (Murcia), and in the supply of all types of goods throughout the provinces of Almeria and Granada. The most important station, that of Zurgena, was restored at the beginning of the 21st century by the Town Council of Zurgena. Currently, a project of rehabilitation and reconstruction of all the railway structures, workshops, turntable and a set of tracks is being developed to reinstall a historic train using the original rolling stock, as a way to recover old techniques and knowledge and offer, in a new way, a real vision of this incredible train line.
Inode -  intelligent open data exploration

Data growth and availability as well as data democratization have radically changed data exploration in the last 10 years. Many different data sets, generated by users, systems and sensors, are continuously being collected. These data sets contain information about scientific experiments, health, energy, education etc., and they are highly heterogeneous in nature, ranging from highly structured data in tabular form to unstructured text, images or videos. Furthermore, especially online content, is no longer the purview of large organizations. Open data repositories are made public and can benefit more types of users, from analysts exploring data sets for insight, scientists looking for patterns, to dashboard interactors and consumers looking for information. As a result, the benefit of data exploration becomes increasingly more prominent. However, the volume and complexity of data make it difficult for most users to access data in an easy way.

In this project we propose INODE – Intelligent Open Data Exploration. The core principle of INODE is that users should interact with data in a more dialectic and intuitive way similar to a dialog with a human. To achieve this principle, INODE will offer a suite of agile, fit-for-purpose and sustainable services for exploration of open data sets that help users (a) link and leverage multiple datasets, (b) access and search data using natural language, using examples and using analytics (c) get guidance from the system in understanding the data and formulating the right queries, and (d) explore data and discover new insights through visualizations.

Our service offering is formed by and will initially respond to the needs of large and diverse scientific communities brought by our three use case providers: (a) Cancer Biomarker Research - SIB Swiss Institute of Bioinformatics, Switzerland, (b) Research and Innovation Policy Making - SIRIS, Spain, and (c) Astrophysics - Max Planck Institute for Extraterrestrial Physics, Germany.
Piperidine-appended imidazolium ionic liquids as task-specific catalysts: computational study, synthesis, and multinuclear NMR

Imidazolium ionic liquids (IMILs) with a piperidine moiety appended via variable length methylene spacers (with n = 1–4) were studied computationally to assess their potential to act as internal base for N-heterocyclic carbene (NHC) generation. Proton transfer energies computed by B3LYP/6-311+G(2d,p) were least endothermic for the basic-IL with n = 3, whose optimized structure showed the shortest C2-H----N(piperidine) distance. Inclusion of counter anion (Cl or NTf2) caused dramatic conformational changes to enable close contact between the acidic C2-H and the anions. To examine the prospect for internal C2-H----N coordination, multinuclear NMR data (1H, 15N, and 13C) were computed by gauge independent atomic orbitals–density functional theory (GIAO-DFT) in the gas phase and in several solvents by the PCM method for comparison with the experimental NMR data for the basic ILs (with n = 2–4) synthesized in the laboratory. These studies indicate that interactions with solvent and counter ion are dominant forces that could disrupt internal C2-H----N coordination/proton transfer, making carbene generation from these basic-ILs unlikely without an added external base. Therefore, the piperidine-appended IMILs appear suitable for application as dual solvent/base in organic/organometallic transformations that require the use of mild base, without the necessity to alkylate at C-2 to prevent N-heterocyclic carbene formation. Copyright © 2016 John Wiley & Sons, Ltd.
Extreme deformation of structured fluids and interfaces. exploiting ultrafast collapse and yielding phenomena for new processes and formulated products

The increasing demand for environmentally friendly, healthier, and better performing formulated products means that the process industry needs more than ever predictive models of formulation performance for rapid, effective, and sustainable screening of new products. Processing flows and end use produce deformations that are extreme compared to what is accessible with existing experimental methods. As a consequence, the effects of extreme deformation are often overlooked without justification.

Extreme deformation of structured fluids and soft materials is an unexplored dynamic regime where unexpected phenomena may emerge. New flow-induced microstructures can arise due to periodic forcing that is much faster than the relaxation timescale of the system, leading to collective behaviors and large transient stresses.

The goal of this research is to introduce a radically innovative approach to explore and characterize the regime of extreme deformation of structured fluids and interfaces. By combining cutting-edge techniques including acoustofluidics, microfluidics, and high-speed imaging, I will perform pioneering high-precision measurements of macroscopic stresses and evolution of the microstructure. I will also explore strategies to exploit the phenomena emerging upon extreme deformation (collapse under ultrafast compression, yielding) for new processes and for adding new functionality to formulated products.

These experimental results, complemented by discrete particle simulations and continuum-scale modeling, will provide new insights that will lay the foundations of the new field of ultrafast soft matter. Ultimately the results of this research program will guide the development of predictive tools that can tackle the time scales of realistic flow conditions for applications to virtual screening of new formulations.