SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Inhibiting mechanotransduction for the treatment of pancreatic cancer

Mechanical forces transmitted between cells and their microenvironment drive cell function and regulate tumorigenesis. Due to this importance, our FET PROACTIVE project MECHANOCONTROL aims to understand the molecular mechanisms by which forces exert their role, and their implications in the specific application of breast cancer. In this context, we have recently identified that the interaction between the cytoskeletal molecules vinculin and talin can be inhibited by a vinculin fragment (VD1) which blocks cell response to mechanical forces, and the activation of the major oncogene YAP that occurs in tissues with abnormally high mechanical stiffness. Both increased tissue stiffness and YAP activation drive tumor progression in most solid tumors, and thus inhibiting talin/vinculin interactions has a major potential as a therapeutic approach in several solid cancer types. We have designed and synthesized peptido-mimetic drugs reproducing the action of VD1. Among those synthesized, we have identified one that inhibits the metabolism of cell lines from pancreatic, colon and prostate tumors. Our aim is to valorize these drugs in the specific case of pancreatic cancer, which is a clear unmet clinical need since it is the one with the least therapeutic alternatives and worst prognosis. Specifically, the funding from this project will pay for the national phases of the current patent (PCT/EP2017/056410), regulatory pharmacokinetics/pharmacodynamics and toxicity tests in mouse animal models, as well as for developing contacts of potential license-takers to close a license agreement. Because the focus is on pancreatic rather than breast cancer, and on bringing a specific drug to the market rather than carrying out research, this project is related to but falls out of the scope of the FET MECHANOCONTROL project.
A MULTI-VEHICLE EXCAVATION SYSTEM

An excavation system utilizes a vacuum truck having a vacuum system in combination with a small backhoe to which an excavator assembly is affixed to the backhoe extendable and articulating arm whereby manipulation of the excavator assembly can be controlled by an operator positioned in the backhoe operator cab. The vacuum assembly and the excavator assembly are operatively attached by an elongated, at least partially flexible vacuum hose operatively attached to the vacuum truck pump to permit material that is excavated to be transported from the excavator assembly to the vacuum assembly for storage or disposal.
AUTO-FIR - Automobile's first information record

Today, technology has been repetitively subjected to changes. So with the inception of technology and improvisation of the same, developments in embedded systems have sky rocketed and are fast approaching the zenith. As an effect of such change over the past several years NHTSA (National Highway Traffic Safety Administration) has been actively involved in using Event Data Recorders (EDR) in high end automobiles like flights, cars and some two wheelers like Kawasaki's Ninja. EDR's collect crash information which assists in real world data collection and also helps in understanding specific aspects of the crash. India ranks first in road accidents, for every 3.7 minutes road mishap snuffs out a life. What are the root causes for so many accidents to happen? Where are the details stored after the accident? Was there any fault with the motorcycle? How about false insurance claims? The proposed work addresses the above questions and aims to collect the information which aids investigations of causes of accident and helps in improvement of motorcycle standards. Information from this device can be collected to determine the condition of motorcycle before the time of accident. An embedded system is mounted on two wheelers which records the events like brake, gear, speed, stand and congestion. The results of analysis show that the recorders can report real world crash data and therefore be a powerful tool by providing useful information to crash reconstruction experts.
Renal allografts in plasma cell myeloma hematopoietic cell graft recipients: on the verge of an explosion?

Renal dysfunction is a common complication of plasma cell myeloma (PCM) that may be severe enough to necessitate hemodialysis. Although high-dose chemotherapy and hematopoietic cell transplant (HCT) appears superior to conventional chemotherapy in likelihood of achieving CR and is associated with improvement in and, at times, reversal of renal dysfunction, many patients remain dialysis-dependent presenting the challenge of renal transplantation in this population. We reviewed the published literature and summarize the outcomes on dual organ (HCT and renal allograft) transplantation in patients with PCM and dialysis-dependent renal failure. In a literature review of 14 reports, 26 of 166 dialysis-dependent patients became dialysis-independent. Our review includes a very heterogenous patient population but suggests that HCT and renal allograft may be feasible in a subset of PCM patients with dialysis-dependent renal failure. Although there is a concern for renal allograft rejection upon withdrawal of immunosuppression, data suggest that resumption of antirejection therapy leads to stable renal function. Bortezomib potentially can be used as maintenance treatment in patients who have not achieved a CR while preventing renal allograft rejection. The literature that describes dual transplants has included patients with long-term follow-up (>7 years in some patients). It is possible, however, that there may be publication bias with only favorable results being reported. More research is necessary to further delineate the subset of PCM patients most likely to benefit from renal transplant. A special registry for data collection for long-term follow-up may be useful to improve future patient survival.
Maximizing the bandwidth multiplier effect for hybrid cloud-P2P content distribution

Hybrid cloud-P2P content distribution (“CloudP2P”) provides a promising alternative to the conventional cloud-based or peer-to-peer (P2P)-based large-scale content distribution. It addresses the potential limitations of these two conventional approaches while inheriting their advantages. A key strength of CloudP2P lies in the so-called bandwidth multiplier effect: by appropriately allocating a small portion of cloud (server) bandwidth S i to a peer swarm i (consisting of users interested in the same content) to seed the content, the users in the peer swarm — with an aggregate download bandwidth D i — can then distribute the content among themselves; we refer to the ratio D i /S i as the bandwidth multiplier (for peer swarm i). A major problem in the design of a CloudP2P content distribution system is therefore how to allocate cloud (server) bandwidth to peer swarms so as to maximize the overall bandwidth multiplier effect of the system. In this paper, using real-world measurements, we identify the key factors that affect the bandwidth multipliers of peer swarms and thus construct a fine-grained performance model for addressing the optimal bandwidth allocation problem (OBAP). Then we develop a fast-convergent iterative algorithm to solve OBAP. Both trace-driven simulations and prototype implementation confirm the efficacy of our solution.
Real-time mobile advertising for the film industry

Research on real-time data processing and telligent control algorithms for the film industry; in addition, a forecasting model and algorithm is to be implemented, which, depending on the anonymised user p rofile, makes valid statements about the film taste of any user.
Emission patterns of traffic-related metals and associated contamination in road deposited sediment

Road deposited sediment (RDS) is regarded as sinks for metal pollutants derived from road-traffic that may pose a danger for the nearby water environment. The reported study aims to analyse RDS build-up and associated metal emission patterns using Riccarton Campus of Heriot Watt University, Edinburgh, Scotland as a study site. The RDS samples were collected from four different sites over a four month period to characterise the influence of road lay-out on metal emissions. The metal concentrations associated with the RDS were determined by strong nitric acid digestion and atomic absorption spectrometry. The outcomes of the investigation show highly site-specific variability of the RDS build-up primarily linked to road lay-out, and that road surface conditions and surrounding land use influenced the results. Similarly, irrespective of traffic volume, site attributes were found to be the drivers for the observed differences in metal concentration. Furthermore, a significant proportion of pollutants were found to be associated with finer particles (size < 63 µm) and that RDS exhibited moderate to strong levels of pollution for Zn, Cu and Pb.
Switch-Off fluorescence of 5-amino-2-mercapto benzimidazole with Ag3O4 nanoparticles: Experimental and theoretical investigations

Abstract The binding interaction of 5-amino-2-mercaptobenzimidazole (AMB) with Ag 3 O 4 nanoparticles was studied. AMB adsorbs strongly on the surfaces of nano semiconductor. The interaction of AMB with Ag 3 O 4 was studied by absorption, fluorescence, FT-IR, SEM and EDX spectral studies. The Ag 3 O 4 nanoparticles were synthesized by chemical route and was characterized by XRD study. Excellent results observed were due to electron transfer between AMB and Ag 3 O 4 nanoparticles. To confirm the binding site of Ag 3 O 4 with AMB, molecular electrostatic potential (MEP) study was carried out theoretically. It confirmed the higher electron density at azomethine nitrogen atom. Photo-induced electron transfer is responsible for fluorescence quenching of AMB. The interaction between AMB and Ag 3 O 4 occurs through static quenching mechanism. The apparent association constant ( K app  = 2.0 × 10 5  M −1 ) was obtained from the fluorescence quenching data.
An investigation of exogenous environmental and scale efficiencies of Indian commercial banks

In this study, a three stage DEA model is used to measure the exogenous environmental efficiency of Indian Banks. The liberalization and globalization of financial markets pose a new challenge as well as provide new opportunities to banking industry in developing countries. Efficiency evaluation of banking sector helps to know about the performance of the banks comparing to other banks working in different environments and under different managements. Non-Performing Assets are used to identify the exogenous environment of a bank. The present study reveals that the public and private sector banks hurt more due to the scale and exogenous environmental inefficiency.
Epidermal sensors as personal chemical environmental monitoring tools

The E-SCENT project aims to develop wearable chemo-responsive sensor arrays for personal monitoring of exposure to volatile airborne pollutants. Indoor levels of volatile organic compounds (VOCs) can be up to 1000 times higher than background outdoor levels, and can have serious harmful health effects. Measurement of exposure to airborne pollutants at the individual level is an integral part of human health risk assessment, but is currently reliant on macro-level air quality data and lacks the necessary tools for monitoring at the individual level. A number of personal environmental monitoring devices have recently emerged, but are constrained to sensing physical parameters. E-SCENT will advance personal environmental sensor technology by developing the first personal chemical environmental monitoring tool comprising an array of cross-responsive materials for colourimetric detection of VOCs in a wearable epidermal patch format to enable seamless collection of multi-parameter exposure data at the individual level. 
A diverse range of chemo-responsive dyes will be incorporated in porous matrices for deposition and encapsulation on stretchable conformable films suitable for integration with the epidermis. Sensor protypes will be developed and their deployment in a variety of indoor environments will enable chemical fingerprinting of ambient VOCs. Sensor colour change upon exposure will be quantitatively measured using smart phone image capture technology with image analysis software to examine sensor colour space and changes. Chemometric analysis of multidimensional colourimetric data will be used for classification of VOC exposure levels. E-SCENT will enable rapid low-cost data generation that will advance air quality research and will prove to be a key technology in informing exposure assessment, related health impacts and counter measures by informing policy development at local and European levels.
Using inverse analysis to find optimum nano-scale radiative surface patterns to enhance solar cell performance

Abstract Nano-scale surface patterning can provide highly spectral-directional absorption properties for thin film solar cells. Achieving optimal surface patterning is an inverse optimization problem that requires a numerical procedure capable of scrutinizing the space of geometry parameters to search for an optimal solution. In this paper, 2-D and 3-D thin film amorphous silicon (a-Si) solar cells with periodic structures are considered, whereby the surface of the solar cell is textured with rectangular metallic nano-patterns for enhancing the solar absorption spectrum. We use FDTD simulations to solve Maxwell’s equations inside the cell area when subject to standard optical irradiation. By means of several numerical optimization techniques such as the Quasi-Newton BFGS method, random search Simulated Annealing, and Tabu Search, we determine optimal specifications for surface nano-patterns. Invoking constrained optimization tools, we incorporate various types of practical constraints into the optimization programs. The resulting cell structures found by the inverse solvers illustrate enhancement factors as high as 1.52 in solar absorption when silver nano-patterns are used, compared to bare a-Si cells. Results demonstrate the efficiency of the selected optimization techniques and their computational efficiency in contrast with the naive brute force alternative and provide a benchmark for comparing the performances of various local and global optimization methods. The global random search optimization techniques (Simulated Annealing and Tabu Search) tend to perform better than the local method (Quasi-Newton), especially for higher problem dimensions.
(11429.27102016.098000705) SOFTSYSTEM 2017

SOFTSYSTEM TRAVAILLE DEPUIS 2012 SUR LA CONCEPTION ET LA CONSTRUCTION DE LIGNES AUTOMATISÉES POUR UN IMPORTANT GROUPE INDUSTRIEL QUI FABRIQUE DES RÉCIPIENTS EN VERRE POUR L’INDUSTRIE PHARMACEUTIQUE. JUSQU’EN 2016, CE TRAVAIL A ÉTÉ RÉALISÉ DANS UN ENVIRONNEMENT INDUSTRIEL STANDARD ET IL N’Y AVAIT PAS BESOIN D’ACCORGENTS PARTICULIERS PAR RAPPORT, PAR EXEMPLE, AUX PRODUITS DE L’INDUSTRIE AUTOMOBILE. En 2016, elle a commencé à travailler dans R &AMP;D OF THE COMPANY WORKS TO prototy AND PRODUCTION LINES. CES PROTOTYPES SONT RÉALISÉS DANS UN ENVIRONNEMENT STANDARD OU DANS UNE SALLE BLANCHE. PARMI LES OBJECTIFS QUE VOUS FAITES? PLACER L’ENTREPRISE EN 2017, LE PLUS? C’EST IMPORTANT? CONSTRUIRE DES MACHINES DANS CET ENVIRONNEMENT STÉRILE SELON LES PROCÉDURES ET RÈGLEMENTS PRESTABILE.OBIETTIVO GÉNÉRAL DU PROJET? L’UTILISATION DE CONSEILS HAUTEMENT QUALIFIÉS POUR LA CONCEPTION ET LA CONSTRUCTION D’UNE NOUVELLE LIGNE DE PRODUITS À METTRE SUR LE MARCHÉ, ET L’OPTIMISATION DE LA STRUCTURE FINANZ
CBCT diagnosis and endodontic management of a maxillary first molar with unusual anatomy of two palatal canals: A case report

It is crucial for any clinician to have a thorough knowledge about the normal anatomy of tooth and always be vigilant for any variations to ensure endodontic success. An anatomic variant like additional canals in the palatal root of maxillary molar is not commonly reported. This clinical case report presents the application of cone beam computed tomography as a useful imaging technique in endodontics for the management of teeth with aberrant anatomy. Here, maxillary first molar having two canals in the palatal root, two canals in mesiobuccal root and one canal in distobuccal root was managed successfully using cone beam computed tomography scan as a diagnostic aid.
Clinical and Histopathologic Features of Fluoroquinolone-Induced Liver Injury

Fluoroquinolone-induced liver injury is rare; no prospective studies of well-characterized case series have been published. We studied patients with fluoroquinolone-induced hepatotoxicity from the Drug-Induced Liver Injury Network (DILIN) to characterize injury patterns, outcomes, and associated features.We identified subjects with fluoroquinolone hepatotoxicity enrolled in the DILIN from September 2004 to January 2010. Demographic, clinical, and laboratory data were analyzed by descriptive statistical methods.Of the 679 registrants in the DILIN prospective study, 12 had fluoroquinolone hepatotoxicity (6 ciprofloxacin, 4 moxifloxacin, 1 levofloxacin, and 1 gatifloxacin). Seven were women; median age was 57 years (range, 23-80 years), and median time from fluoroquinolone start to symptoms was only 4 days (range, 1-39 days). Nine patients developed symptoms on medication; 3 did so 2, 8, and 32 days after stopping the medication. Cases were equally distributed among hepatocellular injury (predominantly increased levels of alanine aminotransferase), cholestatic injury (predominantly increased levels of alkaline phosphatase), and both. Seven patients had immunoallergic features. Patients with mixed hepatocellular and cholestatic injury had mild disease without jaundice; all recovered. In contrast, 2 of 4 patients with hepatocellular injury and jaundice died, 1 of acute liver failure. One patient with cholestatic injury developed vanishing bile duct syndrome and required liver transplantation; another had a persistently increased serum level of alkaline phosphatase.Fluoroquinolone liver injury is rapid in onset and often has immunoallergic features, indicating a hypersensitivity reaction. The pattern of injury can be hepatocellular, cholestatic, or mixed; mixed cases are the least severe. Acute and chronic liver failure can occur.
EVALUATON OF RESULTES BY THE APPLICATION OF BONE IMPLANTATES IN THERAPY OF DEEP DEFECTS OF A PARODONCIUM

Reconstruction of infrabony defects created during chronic inflammatory process in parodontopathy represents the main clinical problem in paradontology. The objective of this research was to compare applications of two bone substituents and evaluate the efficiency of regeneration of deep infrabony defects of paradentium after the application of the new “ Biohapel” material, biphasic calcium phosphate/ poly DL-lactide-co-glycolide. The research included 12 patients of both gender, with the average age 49,7 suffering from clinically manifested parodontopathy. The main criterion in choosing patients for the research was presence of six similar infrabony parodontal defects, at least 4mm deep, in the area of equivalent lower side teeth, on both sides of the jaw. After applying basic causal parodontopathy treatment, defects were divided into two groups: an experimental group (n=72) where defects were reconstructed using “ Biohapel ” bone substituent (on one side of the lower jaw) and control group (n=72) where infrabony defects were reconstructed using β tricalcium phosphate (βTCP) ( Cerasorb®), a preparation very commonly applied in regenerative parodontopathy treatment (on the other side of the lower jaw). Parameters of treatment efficiency were determined before the surgery and 6 months after by measuring the depth of parodontal pocket and the level of junctional epithelium. It was observed that statistically significant differences existed between the experimental and control group (p<0,05) regarding the examined parameters of parodontal regeneration. Application of “ Biohapel” in surgical treatment of infrabony defects of paradentium provides better bone regeneration of paradentium in comparison with application of β tricalcium phosphate which is an acknowledged standard in regenerative treatment.
PARP13 regulates cellular mRNA post-transcriptionally and functions as a pro-apoptotic factor by destabilizing TRAILR4 transcript

Poly(ADP-ribose) polymerase-13 (PARP13/ZAP/ZC3HAV1) is an antiviral factor, active against specific RNA viruses such as murine leukaemia virus, Sindbis virus and human immunodeficiency virus. During infection, PARP13 binds viral RNA via its four CCCH-type zinc-finger domains and targets it for degradation by recruiting cellular messenger RNA (mRNA) decay factors such as the exosome complex and XRN1. Here we show that PARP13 binds to and regulates cellular mRNAs in the absence of viral infection. Knockdown of PARP13 results in the misregulation of hundreds of transcripts. Among the most upregulated transcripts is TRAILR4 that encodes a decoy receptor for TRAIL-a pro-apoptotic cytokine that is a promising target for the therapeutic inhibition of cancers. PARP13 destabilizes TRAILR4 mRNA post-transcriptionally in an exosome-dependent manner by binding to a region in its 3' untranslated region. As a consequence, PARP13 represses TRAILR4 expression and increases cell sensitivity to TRAIL-mediated apoptosis, acting as a key regulator of the cellular response to TRAIL.
Contraception can Lead to Trophic Asynchrony between Birth Pulse and Resources

Abiotic inputs such as photoperiod and temperature can regulate reproductive cyclicity in many species. When humans perturb this process by intervening in reproductive cycles, the ecological consequences may be profound. Trophic mismatches between birth pulse and resources in wildlife species may cascade toward decreased survival and threaten the viability of small populations. We followed feral horses (Equus caballus) in three populations for a longitudinal study of the transient immunocontraceptive porcine zona pellucida (PZP), and found that repeated vaccinations extended the duration of infertility far beyond the targeted period. After the targeted years of infertility, the probability of parturition from post-treated females was 25.6% compared to 64.1% for untreated females, when the data were constrained only to females that had demonstrated fertility prior to the study. Estimated time to parturition increased 411.3 days per year of consecutive historical treatment. Births from untreated females in these temperate latitude populations were observed to peak in the middle of May, indicating peak conception occurred around the previous summer solstice. When the post-treated females did conceive and give birth, parturition was an estimated 31.5 days later than births from untreated females, resulting in asynchrony with peak forage availability. The latest neonate born to a post-treated female arrived 7.5 months after the peak in births from untreated females, indicating conception occurred within 24-31 days of the winter solstice. These results demonstrate surprising physiological plasticity for temperate latitude horses, and indicate that while photoperiod and temperature are powerful inputs driving the biological rhythms of conception and birth in horses, these inputs may not limit their ability to conceive under perturbed conditions. The protracted infertility observed in PZP-treated horses may be of benefit for managing overabundant wildlife, but also suggests caution for use in small refugia or rare species.