SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
POST-MOLDING COOLING APPARATUS FOR PREFORMS MADE OF THERMOPLASTIC MATERIAL

The invention relates to an apparatus for cooling a plurality of preforms made of thermoplastic material which continuously move on a conveyor belt. The apparatus includes a cylindrical casing with a vertical extension formed by two coaxial cylinders, such a casing contains a guide crossed by a chain or a cable for transporting the preforms therein. The guide, which forms a closed path, comprises a first helical stretch, which raises from the lower plane starting from a station in which the preforms coming from a conveying device are hooked by the chain or by the cable, a second straight stretch, which returns the preforms to the lower plane once they have reached the upper plane, and a third flat stretch at the height of the lower plane, which returns the preforms to the arrival station. The helical stretch of the guide is contained within a cooling tunnel formed in the gap between the two walls of the outer cylinder and the inner cylinder of said casing. The cooling air is conveyed within the cooling tunnel by a specific manifold which is located within the casing.
The role of ubiquitination in stability and plasticity of the gabaergic synapse

Proper brain functioning requires a balance between inhibitory and excitatory synaptic activity. This balance can be maintained by regulating the number of neurotransmitter receptors in the postsynaptic membrane. A major inhibitory synaptic receptor is the hetero-pentameric GABAA Receptor (GABAAR), which is stabilised in the synapse by the intracellular scaffolding protein gephyrin. Gephyrin, in turn, is recruited to and stabilised at the synapse by the adhesion protein neuroligin-2 (NL2). Regulation of synaptic strength involves lateral diffusion of GABAARs into and out of synapses, endocytic downregulation followed by either degradation or membrane re-insertion, and altering the size of gephyrin clusters. Altered GABAAR trafficking is implicated in neurological and psychiatric disorders, including epilepsy and excitotoxicity in ischemia. The underlying mechanisms, however, remain poorly understood.
Ubiquitination is a well-known mechanism that regulates protein trafficking and turnover, however its role in stability and plasticity of the GABAergic synapse remains unclear. Preliminary work from the Kittler lab suggests that: 1) the ubiquitin ligase Unk plays a key role in ubiquitination of the GABAAR; 2) gephyrin can be poly-ubiquitinated and that its proteasomal turnover may be regulated by the de-ubiquitinating enzyme OTUD4; 3) NL2 can be mono-ubiquitinated, potentially directing its trafficking, and that the ubiquitin ligase Nedd4 may regulate this process. Thus ubiquitination may play several key roles in regulating the dynamics of receptor, scaffold, and adhesion molecules at the inhibitory synapse. 
Using molecular, biochemical, cell biological, and state-of-the-art imaging approaches I aim to study how ubiquitination of GABAARs, NL2 and gephyrin affects GABAAR trafficking, and formation and stability of the inhibitory synapse. This may lead to improved understanding of how ubiquitination regulates neuronal excitability in healthy and pathological conditions.
Integrated tissue slice culture and nmr metabolomics – a novel approach towards systemic understanding of liver function and disease

We propose the development of a groundbreaking technology platform that, for the first time, integrates nuclear magnetic resonance metabolomics and micro-imaging with microfluidic perfusion tissue slice culture. This will revolutionise life science research with unprecedented local insight into life processes in intact tissues under highly controlled conditions. We focus on liver tissue slice culture, with the immediate target of elucidating the mechanism of liver damage by drug-induced cholestasis. In the long term, the new technology will find wide application in other tissues, including intestinal, pancreatic, and brain slices. It will form the foundation of a new approach in the life sciences, allowing the detailed metabolic
study of tissues at the system level.

Liver disease is a significant and growing public health problem: 29 million people currently suffer from a serious liver condition in the EU. While the causes for some liver conditions are known, the mechanism of liver damage is generally poorly understood, largely due to the difficulty of studying live liver tissue at the systemic level. 
The proposed comprehensive research programme leads to a new technological platform for microfluidic tissue slice culture with direct observation of tissue metabolism and transport processes through nuclear magnetic resonance.

It joins the expertise and creativity of four leading academic groups and one SME representing the disciplines of micro-engineering, physical chemistry, magnetic resonance, biochemistry, toxicology, and clinical hepatology across three institutions from three EU countries.  Due to its high level of interdisciplinary integration, TISuMR is uniquely able to provide emerging researchers with a career springboard.

TISuMR will have a profound impact on wider society by providing alternatives to animal testing, by increasing the efficiency and specificity of drug safety testing,  and by enabling new treatments in the management of liver disease.
Closed-Loop acoustic stimulation during sleep to enhance motor memory consolidation in aging

Research has consistently demonstrated that older adults have difficulties consolidating recently learned movements into robust motor memories. This impairment undoubtedly contributes to the movement deficits emerging with healthy aging and hinders rehabilitative strategies. As consolidation is known to be facilitated by sleep, these movement-related deficits partially result from age-associated degradations in sleep characteristics. 
Accordingly, the project CLASSy Aging (Closed-Loop Acoustic Stimulation during Sleep to enhance motor memory consolidation in Aging) aims to optimize sleep-related motor memory consolidation in healthy older adults. Specifically, during a post-learning nap, I will use forefront real-time electroencephalographic (EEG) analyses to reactivate memories via Targeted Memory Reactivation time-locked to neuroplasticity-related physiological events of interest (i.e., sleep spindles and slow oscillations). This project will use a novel and sophisticated approach designed to boost sleep-dependent consolidation and minimize previously observed aging-related deficits. I will unravel the neural correlates of the memory reactivation process using high-density EEG during post-learning sleep and the stimulation-enhanced neuroplasticity processes during task practice using functional Magnetic Resonance Imaging (MRI). This project uses a comprehensive approach as the brain will be imaged at different phases of the memory formation (i.e., learning, consolidation and retest) making use of cutting-edge neuroimaging analyses (univariate and multivariate MRI analyses, sources localization of hdEEG signal) tailored to each of these phases. This ambitious, yet feasible, multimodal neuroimaging project will provide significant insights into motor memory processes. It will offer new avenues to amplify neuroplasticity, alleviate motor deficits, and increase well-being in not only healthy aging, but ultimately in those with neurological conditions.
Large-Scale production method of graphene to reach the market in an effective way

The market for graphene is expected to experiment a great growth in the coming years being applied in a wide variety of sectors (automotive and aerospace industries, advanced composites, among others).Graphene industry will be about 133.77 million € by2020, and up to 440 million Euros by 2024.  However, to reach this estimations there is a need to face the challenges existing today to commercialise graphene: to produce high quality material, on a large scale at low cost, and in a reproducible manner. Most of producers’ retail prices are between 150-230 €/Kg  with only one competitor (from US) in the market offering prices below 100 €/Kg. In terms of capacity, he largest production plant in Europe is limited to 1 Tn.

In this context, Eficiencia Energética Aplicada a technological Company supported from 2010 by the Spanish Ministry of Science and Innovation is working to industrialise an innovative and environmental-friendly technology, dry micro-mechanical exfoliation (PCT/ES2016/070058) solution which enables the high quality (95.5%) and large-scale production of graphene nanoplatelets.  Our present objective is to go from a small-scale prototype (20kg graphene nanoplatelets/day) to 280 kg/day in 2018, a required step to ensure industrialisation and standardisation of the large scale production (the largest in Europe with 300 Tn/year in 2022). The work plan proposed by EEA will accelerate the innovation process by up-scaling a single reactor for 20 kg to 70 kg/day and adapting an optimized automation of the process (one rector and 4 reactors working continuously with 280 kg/day). This technological upgrades are crucial to meet expected retail prices and to ensure to European manufactures a large stock of graphene in Europe.

Besides, EEA will work in the market implementation, and will perform tests for the demonstration of the produced graphene nanoplatelets in products of the coatings, polymers, ink and lubricant industries. By 2022, expects an accumulated turnov
A networked approach to dynamic analysis of social system vulnerability

Given the high vulnerability of social system to disruptions, it is very critical to make scientific analysis on the vulnerability of social system and further manage its vulnerability, especially for today's highly networked society. The focus of this work is on the dynamic analysis for the vulnerability of social system under considering the cascading phenomenon. Considering that a social system with interconnected agents is better modeled as a network than as a linear chain, we introduce a networked approach to investigate the structural characteristics of social system first. Then a social system is modeled as a social network graph. Furthermore, a cascading model and a new vulnerability measurement based on the model are proposed to analyze the vulnerability of social network. Finally, the illustrative example of a real social system is given to indicate the effectiveness and usefulness of the proposed framework. The study provides some new insights about the vulnerability of social system, and is also helpful to discover the global potential behaviors during cascading failure spreading within social system.
Farmers income and savings pattern in Benue State, Nigeria

The study analysed farmers’ income and savings pattern in Benue State. Both multi-stage random and purposive sampling procedures were employed to select 140 respondents for the study. The study employed primary data which were collected through the use of the structured questionnaire. The result showed that farm size, level of access to credit, diversification of income sources, types of investment and risks inherent in the business are the major determinants of the income level of the small scale farmers. The farmers engaged in the following farm activities, crop production, hunting, fishing, gathering of forest products, marketing of agricultural products and livestock production. Meanwhile, trading, teaching, and non-farm wage labour were the main non-farm activities they engaged in. The result equally showed that farmers adopted both formal and informal savings methods but have higher preference for the informal method as indicated by their preference for savings in rotational savings and credit Association (ESUSU) and daily contribution schemes. Educational attainment, annual income, farming experience, and farm size had positive influence on the farmers’ savings pattern. The test of the hypothesis indicated that the socio-economic characteristics of the small scale farmers have significant effects on the savings pattern adopted in the area. Consequently, the study recommended the establishment of banks in the rural area so as to increase farmers’ savings capacity in formal sector; establishment of enlightenment programme to create awareness among the rural farmers, and introduction of risk reduction policy to minimize risks associated with farming, thereby encouraging farmers to remain in farming business.Keywords: Farm activities, non-farm activities, farmers, formal and informal savings
Astrocyte-Neuronal crosstalk in obesity and diabetes

Despite considerable efforts aimed at prevention and treatment, the prevalence of obesity and type 2 diabetes has increased at an alarming rate worldwide over recent decades. Given the urgent need to develop safe and efficient anti-obesity drugs, the scientific community has to intensify efforts to better understand the mechanisms involved in the pathogenesis of obesity. Based on human genome-wide association studies and targeted mouse mutagenesis models, it has recently emerged that the brain controls most aspects of systemic metabolism and that obesity may be a brain disease. I have recently shown that like neurons, astrocytes also respond to circulating nutrients, and they cooperate with neurons to efficiently regulate energy metabolism. So far, the study of brain circuits controlling energy balance has focused on neurons, ignoring the presence and role of astrocytes. Importantly, our studies were the first to describe that exposure to a high-fat, highsugar (HFHS) diet triggers hypothalamic astrogliosis prior to significant body weight gain, indicating a potentially important role in promoting obesity. Overall, my recent findings suggest a novel model in which astrocytes are actively involved in the central nervous system (CNS) control of metabolism, likely including active crosstalk between astrocytes and neurons. To test this hypothetical model, I propose to develop a functional understanding of astroglia-neuronal communication in the CNS control of metabolism focusing on: 1) dissecting the ability of astrocytes to release gliotransmitters to neurons, 2) assessing how astrocytes respond to neuronal activity, and 3) determining if HFHS-induced astrogliosis interrupts this crosstalk and contributes to the development of obesity and type 2 diabetes. These studies aim to uncover the molecular underpinnings of astrocyte-neuron inputs regulating metabolism in health and disease so as to
inspire and enable novel therapeutic strategies to fight diabetes and obesity.
Better, faster, smarter: developing a blueprint for creating forensic accountants

Purpose – The purpose of this article, which is based on author's study, is to highlight the essential attributes of forensic accountants and to construct the forensic accountant “blueprint” as a reference for forensic accounting education and training. Design/methodology/approach – This study uses primary and secondary data on forensic accounting profession in Indonesia and the USA. Such data were collected by means of literature reviews, in-depth interviews, and a focus group discussion with a number of forensic accounting professionals in Indonesia and the USA. Findings – The author establishes that the “problem-based” nature of forensic accounting requires a unique approach in producing forensic accountants compared to ordinary accountants. The essential attributes that a forensic accountant needs to possess are mentality, method, and experience. “Mentality” consists of elements such as ability to differentiate the right from the wrong, courage to stand up for what is right, ability to withstand pressures from the works, and puzzle solving mindsets. “Methods” refer to the understanding of the fraud investigation process such as fraud detection, evidences, investigation methods, and investigation report. “Experience” as the third attribute is gained primarily through involvement in fraud investigation process in which a forensic accountant utilizes his or her knowledge previously acquired through education and training. Research limitations/implications – Forensic accounting is a problem oriented skill that may differ across countries. Due to the time and financial resource constraint, this study is limited only on two countries and a small number of respondents. For future study, more countries and respondents should be included in analysis to gain a more complete picture on what constitute a forensic accountant. Practical implications – The results of this study contribute to the development of human resource in the forensic accounting profession. More specifically, they serve as a reference in the development of curriculum for forensic accounting education and training especially in Indonesia. Originality/value – This paper sees forensic accountant skill development from the “demand” point of view by highlighting what that the profession expects from a forensic accountant.
Crimean-Congo haemorrhagic fever vaccine

Natural epidemics and outbreaks of emerging viral epidemics are growing problems internationally. The general aim of the CCHFVaccine project is to develop and deliver a vaccine, which can significantly increase our capacity to control the situation of Crimean Congo Haemorrhagic fever (CCHF) disease on a global basis. The proposed work program on CCHF virus aims to build a multidisciplinary research network, able to deliver vaccine candidates, methods and procedures eligible for clinical trials, with a special focus on prevention. Thanks to the background, unique facilities and tools available among the consortium participants, CCHFVaccine will deliver tools for countering the threat of this infection in Europe and endemic areas of the world. This work program will attempt to fill gaps in CCHFV virus research on immunology and vaccinology. To achieve this overall aim, an intensive work plan will be put in place with the following specific objectives: i) to produce vaccine candidates, ii) to bring several unique animal models into front line vaccine research, iii) to validate and bring the most promising vaccine candidates to clinical trials, iv) to ensure that an immune mediated protection is adequately understood, v) to perform clinical trials at Phase I and ensure a strategy for the effective deployment and utilization in resource-poor countries, and vi) to link this project to public health bodies, NGOs and vaccine companies. 
The proposed CCHFVaccine project will succeed in bringing together selected competitive advantages such as: operating capacity with appropriate facilities (state-of-the-art BSL-4s) and the only animal BSL-4  -with capacity to challenge domestic animals in Europe, highly experienced researchers in the development and evaluation of vaccine candidates, authorities and entities of human and animal health, clinical samples from endemic countries, and an international network proven to be functional by the previous EU-funded CCHFever and EDENext.
Occupants’ adaptive responses and perception of thermal environment in naturally conditioned university classrooms

A year-long field study of the thermal environment in university classrooms was conducted from March 2005 to May 2006 in Chongqing, China. This paper presents the occupants’ thermal sensation votes and discusses the occupants’ adaptive response and perception of the thermal environment in a naturally conditioned space. Comparisons between the Actual Mean Vote (AMV) and Predicted Mean Vote (PMV) have been made as well as between the Actual Percentage of Dissatisfied (APD) and Predicted Percentage of Dissatisfied (PPD). The adaptive thermal comfort zone for the naturally conditioned space for Chongqing, which has hot summer and cold winter climatic characteristics, has been proposed based on the field study results. The Chongqing adaptive comfort range is broader than that of the ASHRAE Standard 55-2004 in general, but in the extreme cold and hot months, it is narrower. The thermal conditions in classrooms in Chongqing in summer and winter are severe. Behavioural adaptation such as changing clothing, adjusting indoor air velocity, taking hot/cold drinks, etc., as well as psychological adaptation, has played a role in adapting to the thermal environment.
Improvements in and relating to the stapling of materials by means of wire staples

784,810. Staples. MEZGER, H. Oct. 4, 1955 [Dec. 3, 1954], No. 28207/55. Class 89(2) A staple comprises a back 1 and legs 2, each joined to the back through an inclined-portion 2c and having an inclined - pointed end 2a set inwards to the same extent as portion 2c. For use in a stapling- machine a number of the staples are assembled together to form a strip.
Investigation of Hydro-Geochemical Characteristics of Groundwater In Port Harcourt City, Nigeria: Implication For Use and Vulnerability

A hydrogeochemical evaluation of groundwater in Port Harcourt City, Southern Nigeria has been carried out. Thirty two (32) groundwater samples were analysed for their physical, chemical and microbiological properties. The average temperature of the groundwater samples is 29 oC, The water is slightly acidic with pH values between 4.28 – 7.72. Elevated Electrical Conductivity (EC) values in some coastal wells suggest possible pollution by seawater. The study also reveals saltwater contamination in the area as Chloride contents in some boreholes are up to 710.00mg/l. Besides of the major chemical compositions, ionic ratio (HCO 3 /Cl, Na/Ca, Ca/Cl, Mg/Cl and Ca/SO 4 ) was used to delineate saline water intrusion. Iron and Manganese concentrations are above the World Health Organization guide value in majority of the boreholes studied, with maximum value up to 1.60mg/l in Abuloma area. Constituents of the heavy metals as shown in this study reveal that, in some locations, values are slightly higher than the permissible levels. Microbial analysis of the water samples to determine the presumptive coliform count of the water indicates the presence of coliform bacteria in majority of the analysed samples, indicating anthropogenic contamination of groundwater. The water is generally classified as soft and fresh based on its hardness and Total Dissolved Solids (TDS), which ranges from 2.50mg/l – 142mg/l and 2.60mg/l – 401mg/l, respectively. The analytical results present the abundance of the ions in the following order: Mg > Ca > Na > K = Cl > SO 4 > HCO 3 > NO 3 . Chloride is the dominant anion found in the groundwater of the study area. Piper trilinear diagram for the study area shows that there is a mixture of two types of water with variable concentrations of major ions. These are Ca – Mg –Cl – SO 4 type and Na + K – Cl – SO 4 type water. The second water type is also influenced by NO3. This means that groundwater in the area is mainly made up of mixtures of earth alkaline and alkaline metals and predominantly Cl- -SO 4 2-water type. Most of the water samples are made up of mixtures of the two water types. The study provides the basic tool for sustainable groundwater management in the area in the context of quality assessment. @JASEM J. Appl. Sci. Environ. Manage . Sept, 2011, Vol. 15 (3) 479 -488
QUINT-FOCAL DIFFRACTIVE INTRAOCULAR LENS.

A diffractive quint focal intraocular lens includes a base optic and a diffractive element. The base optic has a base curvature that corresponds to a base power. The diffractive element provides constructive interference in at least five consecutive diffractive orders to create a set of five focal points for vision from near to distance. The constructive interference provides for a near focal point at the highest diffractive order of the five consecutive diffractive orders, a distance focal point at the lowest diffractive order, and three intermediate diffractive orders between the highest and lowest diffractive orders to provide continuity of vision from near to distance with an extended intermediate, an intermediate, and an extended near focal points. The multifocal intraocular lens (i) provides a diffraction efficiency of -100%, (ii) creates almost no positive optical disturbance, (iii) may also reduce longitudinal chromatic aberration.