SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Origin and protection of unstable repetitive dna elements during sexual reproduction

The objective of this proposal is to define the molecular basis behind the origin and protection of unstable repetitive DNA sequences during sexual reproduction. Eukaryotic genomes contain large amounts of repetitive elements that serve vital roles in cellular physiology. However, repetitive elements are intrinsically unstable, which is caused by a high likelihood for incorrect repair when DNA breaks form within repetitive elements. During sexual reproduction, numerous DNA breaks are actively introduced into the genome, and repetitive sequences particularly threaten genome stability during this specialized developmental program. 
We will use the repetitive budding yeast ribosomal (r)DNA array as a model locus to study repetitive DNA instability. Our previous work showed that the outermost elements of this large repetitive array (i.e. rDNA array boundaries) are DNA break ‘fragile sites’, which attract DNA breaks during sexual reproduction. Importantly, we isolated the first known enzymatic ‘anti-DNA break’ system, which minimizes DNA break formation at rDNA array boundaries and as such is crucially required to maintain genome stability.
In the experiments outlined here, we will use a combination of genomics, molecular biology and biochemistry to: 
1) Interrogate the origins of the vulnerability of the repetitive rDNA boundaries for DNA breaks, and
2) Define how a first-in-class ‘anti-DNA break’ system locally protects against DNA break formation. 
These studies will serve as a paradigm for repetitive DNA instability, yielding major insights into the general principles that govern protection of vulnerable genomic elements during sexual reproduction. It is well established that incorrect repair of DNA breaks involving repetitive sequences during sexual reproduction causes a myriad of human congenital disorders. Therefore, we foresee that insights gained from this work have the potential to help us understand the aetiology of human genetic disease.
Fluid corpus manipulation: creative research in musical mining of large sound/gesture datasets through foundational access to the latest advances of signal decomposition.

The FluCoMA project instigates new musical ways of exploiting ever-growing banks of sound and gestures within the digital composition process by bringing breakthroughs of signal decomposition DSP to the toolset of techno-fluent computer composers for the first time.
Cutting-edge musical composition has always been dependent on, critical and subversive of the latest advances of technology. Unfortunately, there is a contemporary challenge inherent to aesthetic research in computer composition: an ever-expanding gap between DSP advances and their availability to musical investigators.
One such advance is signal decomposition: a sound can now be separated into its transient, pitched, and residual constituents. These potent algorithms are partially available in closed software, or in laboratories, but not at a suitable level of modularity within the coding environments used by the creative researchers (Max and SuperCollider) to allow groundbreaking sonic research into a rich unexploited area: the manipulation of large sound corpora. Indeed, with access to, genesis of, and storage of large sound banks now commonplace, novel ways of abstracting and manipulating them are needed to mine their inherent potential.
FluCoMa proposes to tackle this issue by bridging this gap, empowering techno-fluent aesthetic researchers with a toolset for signal decomposition within their mastered software environments, in order to experiment with new sound and gesture design untapped in large corpora. The three degrees of manipulations to be explored are (1) expressive browsing and descriptor-based taxonomy, (2) remixing, component replacement, and hybridisation by concatenation, and (3) pattern recognition at component level, with interpolating and variation making potential. These novel manipulations will yield new sounds, new musical ideas, and new approaches to large corpora. At present, no library exists allowing such cutting-edge research on creative fluid corpus manipulations to be done
Polycentric Planning Models for Local Development in Territories interested by Corridor 5 and its TEN-T ramifications

The main problem addressed is the marginalization that a major transport infrastructure (MTI) can cause to alpine areas. The project aims at making mountain areas catch the opportunities of MTIs, rather than just suffer their environmental and social impact, targeting the phases of piloting and policy implementation.
The project foresees the elaboration of an unbiased method to measure the value of an alpine area and to maximize it, given the presence of a MTI. A polycentric development toolkit will synthesize the method providing indication to public actors for each phase of MTIs life-cycle. Pilot actions will test some solutions and final validation of the toolkit will lead to guidelines integrating project results in transnational policies, adopted by policy makers at different administrative level. A transversal activity will be the involvement of local communities to build consensus, raising awareness on the importance of participating and controlling public choices/processes.
Design and setting-up of a museum network: RMG project

The creation of a Museum Network in the province of Gorizia requires some specific projects envisaging communication and promotion activities for the reference public actors (schools and universities, local visitors and tourists, institutional counterparts, scientific communities). In particular, the project envisages the creation of a museum system logo, to identify all the activities carried out in the framework of cross-border cooperation, and the publication of an annual report about the activities performed, as a first mutual accountability instrument available to museum organizations and the main stakeholders. A web portal is going to be created, for every museum organization to learn about its visitors and their requirements, in order to ensure an efficient coordination, to promote activities and to manage relationships with visitors, especially as far as visitors’ reception services are concerned. A single electronic ticket providing for integrated services will be issued; it is an important communication and promotion instrument, which aims at ensuring the visitors’ fidelization and improving tourists’ participation. It contributes to the idea of a museum system, offering a single and consistent image of the whole project. The main objective of this initiative is ensuring an organizational form that can enhance the services provided by the museums and combining their resources and attractive capacity, thus integrating the museum services offered in the area through common promotion and enhancement activities. The “RMG” initiative is conceived as a starting point for a more organized and flexible museum system, which can evolve and develop over time.
Cyprus center for algorithmic transparency

Despite strong indications that Cyprus is now in stable economic recovery, and that the island boasts one of the highest rates of tertiary educational attainment in Europe, the picture painted regarding the level of digital skills among citizens is a dismal one. In the 2017 Digital Economy and Society Index, Cyprus ranked 22nd within the EU, and belongs to the cluster of low performing countries. These findings are particularly worrying in light of the rapid changes taking place in the information landscape, such as the global consolidation of networked information services, and the rise of proprietary algorithmic processes that mediate citizens’ access to information and opportunities. The project will establish a network of researchers with key expertise in the areas of informatics and algorithmic biases, enhancing the Cyprus Center for Algorithmic Transparency, a research center at the Open University of Cyprus (OUC). CyCAT will become the regional expert in issues of information access in light of algorithmic gatekeeping, working with local authorities, librarians and educators to promote algorithmic transparency and enhanced digital literacy skills. Expected outcomes are 1) raising the international profile of the OUC researchers as evidenced by invitations to serve on committees, editorial boards, invited talks; 2) increased output in terms of number and quality of publications of OUC researchers; 3) attraction of additional external research funds to sustain CyCAT. Expected broader impacts include: 1) creation of digital artifacts through showcase projects that are relevant to Cypriots’ information needs and that can help raise awareness of algorithmic bias in the systems they routinely use; 2) educational materials based on CyCAT scientific outputs, that can be used by librarians and teachers; 3) increased opportunities for young researchers engaged with CyCAT; 4) increased dialogue on the importance of digital skills.
Developing action competence for insect preservation

The proposed research project ""Developing Action Competence for Insect Preservation"" (DACIP) approaches the current problem of insect decline from an educational perspective using methods of Educational Design Research (EDR). The research project aims to (i) improve theoretical understanding of citizens’ readiness to take action against insect decline and (ii) to design and investigate options to raise citizens' abilities to preserve insects. To achieve these aims, a novel theoretical framework - Action Competence for Insect Preservation (ACIP) - will be developed in a first step. In a second step, this framework is used for developing novel quantitative and qualitative research instruments to investigate citizens' abilities to preserve insects and for designing innovative educational interventions to raise citizens’ ACIP. These interventions will include wildlife gardening and citizen science as core elements. In a third step, the effectiveness of these interventions will be assessed: For this assessment, the designed interventions will be implemented at compulsory schools in Karlstad (grade 7). The change of ACIP will be assessed in a pre-post-design with 500 students, comparing the intervention group with a control group using the new quantitative and qualitative instruments. Consequently, the proposed research project provides three important benefits: a) The new framework (ACIP) builds a foundation for the development of conservation initiatives addressing citizens effectively b) The new instruments make it possible to investigate citizens'  abilities in preserving insects: This can be used to assess the effectiveness of initiatives focusing on insect preservation, which can boost the effectiveness of such iniatives by enabling targeted improvements. c) The designed interventions to foster citizens' ACIP will be made available on a large scale. Therefore, the project can contribute significantly to achieve global biodiversity and sustainability goals.
MarItime and MultimOdal Sustainable pAssenger transport solutions and services

MIMOSA project, with the aim of improving the offer of multimodal sustainable passengers transport solutions and services, promotes a new cross-border approach for passenger mobility in the Programme area. The project partnership, composed by the main actors at regional and national level in both countries, is determined to jointly tackle the common challenge of increasing multimodality, reducing the impact of transport on environment. Having a result-oriented approach, in developing visible outputs, ranging from multimodal solutions to innovative and smart tools and technologies, MIMOSA is focused to change the current situation affecting the cross-border and regional connections, making more accessible, low-carbon and sustainable the mobility of passengers in the whole Programme area. A cross-border cooperation approach is necessary for solving the common problems of a predominant road traffic and of a low level of connectivity between the two countries, for providing to citizens and tourists a wider offer of mobility sustainable options, based on a shared knowledge on transport demand and passengers habits and needs, which makes the project original in comparison to previous initiatives. Thus contributing in achieving the medium-term result of passengers behavioural changes.
Physical optical properties and crystal structures of organic 5-sulfosalicylates – Theoretical and experimental study

Abstract A discussion on the possible application of the organic 5-sulfosalicylates as organic materials with tunable optical and non-linear-optical (NLO) properties is performed on the basis of the experimental crystallographic and spectroscopic methods such as single crystal X-ray diffraction, electronic absorption, diffuse reflectance and fluorescence spectroscopy in condense phase, conventional and linear-polarized IR- and Raman spectroscopy in solid-state. The model systems 5-sulfosalicylic acid dihydrate ( 1 ), 4-aminobenzamidinium bis(5-sulfosalicylicilate) monohydrate ( 2 ) and 5-sulfosalicylicilate salt of glycinamide ( 3 ), comparing with the as well as theoretical quantum chemical calculations of the systems neutral 5-sulfosalicylic acid ( I ), its mono-( Ia ) and dianion ( Ib ), respectively.
Een anatolia supports to increase the innovation management capacities of smes

The proposed project addresses the action for “Establishing services “Enhancing the innovation management capacity of SMEs” in the Enterprise Europe Network” to improve the innovation management capacity of SMEs. In the period covering the years 2015-2021, Tier 1 and Tier 2 services were offered to SMEs by EEN Anatolia Consortium. (The contents of Tier 1 and Tier 2 were respectively generic promotion, networking services given by EEN staff and specialized advisory services given by innovation advisers). The activities foreseen under this proposal is to give Tier 3 services to SMEs.106 full enhancing SMEs’ innovation management capacity service packages and 20 Key Account Management service packages will be offered to SME’s till the end of 2021 and every service package is foreseen. Partner 06 of EEN Anatolia Consortium, has undergone changes in the structure and staff of the organization and will be inactive in 2020-2021.
Inventory forecast of underground gas storage based on modified material balance equation

Abstract In view of the gap between the gas storage inventory forecasted by the traditional material balance equation and the actual inventory, experiments of displacing gas by water and displacing water by gas were carried out, and the modified material balance equation considering pore volume loss due to water invasion and pay heterogeneity was deduced based on the percolation mechanism inferred from the experiments above, moreover the equation was verified by example analysis. The experimental results show that: the irreducible water saturation and residual gas saturation in underground gas storage (UGS) domain should be evaluated through water-gas seepage experiments because these parameters are different from the process of gas field development; the pore volume in the water flooded reservoir decreases after conversion for gas storage, and the pore volume loss increases rapidly when the reservoir permeability decreases. The net pay was divided into flooded zone, transitional zone and gas zone with the equations for pore volume loss calculating due to water flooded. Then one parameter describing reservoir heterogeneity was defined based on numerical simulation and eventually the traditional material balance equation was modified with the consideration of pore volume loss due to water invasion and reservoir heterogeneity. Example analysis result shows that the actual UGS inventory differs greatly from the inventory predicted by the traditional material balance equation, but agrees with that calculated by the modified one.
Modeling a New Water Channel That Allows SET9 to Dimethylate p53

SET9, a protein lysine methyltransferase, has been thought to be capable of transferring only one methyl group to target lysine residues. However, some reports have pointed out that SET9 can dimethylate Lys372 of p53 (p53-K372) and Lys4 of histone H3 (H3-K4). In order to understand how p53 can be dimethylated by SET9, we measured the radius of the channel that surrounds p53-K372, first on the basis of the crystal structure of SET9, and we show that the channel is not suitable for water movement. Second, molecular dynamic (MD) simulations were carried out for 204 ns on the crystal structure of SET9. The results show that water leaves the active site of SET9 through a new channel, which is made of G292, A295, Y305 and Y335. In addition, the results of molecular docking and MD simulations indicate that the new water channel continues to remain open when S-adenosyl-L-methionine (AdoMet) or S-adenosyl-L-homocysteine (AdoHcy) is bound to SET9. The changes in the radii of these two channels were measured in the equilibrium phase at the constant temperature of 300 K. The results indicate that the first channel still does not allow water to get into or out of the active site, but the new channel is large enough to allow this water to circulate. Our results indicate that water can be removed from the active site, an essential process for allowing the dimethylation reaction to occur.
Contributing to shift2rail's next generation of high capable and safe tcms phase 3

Continuation project of CONNECTA-2 (GA 826098) which targets the high TRL deployment and validation in two relevant laboratory
demonstrators and field tests for urban and regional scenarios of the following technologies:
- Wireless TCMS, including wireless train backbone, wireless consist network and standardized train-to-ground according to IEC 61375-2-6.
- NG-TCN including high safe (SIL4) communication networks to support the drive-by-data concept, including brake-by-wire.
- Functional Open Coupling (FOC)
- Functional Distribution Framework (FDF) instantiated with two different approaches (modified AUTOSAR and selfimplemented
on top of specific operating system), together with relevant application profiles.
- The virtual certification simulatiom framework, with hardware-in-the-loop and remote connectivity to subsystems
The goal is to reach TRL6/7 in most developments.
The smartest non-energy aeration system for water cleaning facilities

The OxTube is the smartest device when it comes to dissolving oxygen and other gases into water or liquids. 
One of the most important stages in the water cleaning systems, specifically in potable water treatment (PWT) facilities, is the aeration systems. This process consists in the use of oxygen from the air  to generate a kinetic diffusion into the raw water, where oxygen moves from the air to the water, oxidizing, and boosting the growth of micro-organisms which absorb, process and deactivate dissolved chemicals and foreign matter. Water oxidation also allows to separate iron, metals and other different particles from the water. 
The current air injection technologies used in PWT plants to oxygenate water incur in high energy costs, due to the high electric consumption of the air pumping equipment. Air injection systems consume about 50% of total electricity used in PWT facilities .  We estimate that electricity costs of aeration at a European municipal PWT facility for a community of 200,000 people amount to around €204 K annually.  
Thanks to SANSOX technology, forced pumping air is not necessary. Instead of this, effortless 100% oxygen saturation (efficiency) is achieved by kinetic diffusion (movement of molecules or atoms from a region of high concentration to a region of low concentration, produced for the kinetic energy of these particles), without electricity consumptions, saving up to 50% of total PWT costs.  
Clean water with natural balance of gases and minerals plays the central role in the quality of life of people, their health and contributes for higher life expectancy. Growing urban areas with constantly increasing density of population directly contribute to climate changes via waste water discharge and water treatment activities. OxTube contributes to the solution of those challenges via wiser use of energy, materials, space by handling water-gas mixing and separation processes in the most effective way.
Pier Paolo Pasolini and the medium of song: texts written for Laura Betti for the Giro a vuoto show

This article focuses on the outcome of an important episode within contemporary Italian culture: the encounter between the world of literature and song, and specifically examines the lyrics written by Pier Paolo Pasolini for the actress and singer Laura Betti for the Giro a Vuoto show, performed in 1960 in Milan. This essay intends to highlight the key elements of this encounter and the characteristic elements of these songs by virtue of textual and stylistic analysis, and provide remarks with regard to the relationship between music, text and singing performance. A study of this kind allows emphasis to be placed on the innovation originating from this distinctive collaboration which represents an important sign of change towards the emergence of a quality song within the mass market which would later come to be defined as canzone d'autore (singer-songwriter genre).
Pelaksanaan dakwah Persatuan Islam Tionghoa Indonesia (PITI) di Medan Sumatera Utara: Kajian tentang masalah dan cabaran / Abdi Syahrial Harahap

The research is aimed at investigating the Indonesian dakwah organization of Muslim Tionghoa or known as Persatuan Islam Tionghoa Indonesia (PITI) which is located at Medan District, North Sumatera-Indonesia, mainly regarding its existence as organization of dakwah, its strategy, problems and challenges as well as its effort to make the dakwah more effective and efficient. Qualitative case study was employed as the method to arrive at the conclusions of the study. While, survey was employed to support qualitative data as second sources. Document analyses, observations and interviews with six members of the organization and an observer of Muslim Tionghoa had been conducted upon which data were analyzed by employing thematic analysis and coding. The findings indicate that the PITI as an asset of Islamic movement had contributed to bridge the psychological transition especially for muallaf who faced their hindrances among their family and community because of the change of their belief and convert to Islam. Islamic teaching was a special program offered by PITI to help muallaf to enforce their belief and to enhance their knowledge regarding Islam. PITI also developed its strategy to establish the existence of the organization whether through networking and making relationship with the other Islamic organization such as Muhammadiyyah, NahdhatulUlama (NU) and al-Washliyah or through assimilation and developing diverse cultural approach among various communities. PITI also develops integrated method accordingly in the dakwah based on demands and needs through combination manners of dakwah bil hall (good performance), hikmah (wise), jadal (debate) and qishash (history). The internal and external problems which are faced by PITI include leadership and management, availability of infrastructure and human resources, financial sources, ethnic identity, cultural and habitual old life and Christianization, while an effort to make dakwah more effective is to solve the problems mentioned. Therefore, PITI plans to reshuffle structurally and administratively of the organization, establishing financial sources such as setting up bureaus of trade and travel and employing electronically mass media and publishing as a medium of dakwah.