SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
In vivo single-cell mechanomics of bone adaptation and regeneration in the aging mouse

Osteoporosis, one of the most prevalent degenerative diseases, is characterized by a reduction in bone mass and increased fracture risk and has been partly attributed to the decrease in mechanical usage of the skeleton. A detailed understanding of the molecular mechanisms governing load-regulated bone remodeling could therefore lead to the identification of molecular targets for the development of novel therapies. Bone remodeling is a multiscale process mediated through complex interactions between multiple cell types and their local 3D environments. However, the underlying mechanisms of how cells respond to mechanical signals are still unclear. By combining single-cell “omics” technologies with well-established tissue-scale models of bone mechanobiology, MechAGE proposes to develop the technology required to allow spatially resolved in vivo single-cell mechanomics of bone adaptation and regeneration. CRISPR/Cas technology will be exploited to generate fluorescent reporter mice to identify the different cell types involved in the bone remodeling process. By combining RNA-sequencing of single cells isolated by laser-capture microdissection with micro-finite element analysis and time-lapsed in vivo micro-CT, MechAGE will link the transcriptome of hundreds of single cells to their local mechanical in vivo environment (LivE). This will allow investigation of molecular responses of the cells to LivE changes with aging in established mouse models of bone adaptation and regeneration. In addition to in vivo mechanomics, MechAGE proposes to use cellular and multiscale computational modeling to run in silico simulations of real-world events for better understanding of diseases of aging in mice and to maximize the use of the high quality in vivo mechanomic data. Findings from MechAGE will lead to a systems level understanding of the spatio-temporal regulation of gene expression during the process of load-induced bone adaptation and regeneration in the aging mouse.
ELECTRICAL SUPPLY CABLE FOR A VEHICLE

The present invention relates to a supply cable (10) for electrically connecting a stored energy source (11) of a vehicle (12) to an energy supply device (16) which supplies electrical energy, the supply cable (10) comprising: - a connecting cable (13); - a primary connector (14), which is or can be electrically coupled to the connecting cable (13) and which has a vehicle connection point (14A) for temporarily electrically connecting to the vehicle (12), more particularly to the stored energy source (11); - a secondary connector (15), which is or can be electrically coupled to the connecting cable (13) and which is designed to be temporarily electrically connected to the energy supply device (16); wherein: the supply cable (10) has a detection apparatus (4), which is designed to monitor the electric current supplied by the energy supply device (16) and to detect a termination incident (400) of the supplied electric current; the supply cable (10) has a limiting unit (3), which is designed to limit an electric current flowing through the supply cable (10) to a maximum value (100); and the detection apparatus (4) is designed such that, on the basis of a current supplied before the detection of the termination incident (400), the detection device transfers a limit value (200), as the maximum value, to the limiting unit (3) and/or outputs said limit value as a signal value, more particularly as a proposal for setting as the maximum value (100).
Remote controlled defrost sequencer

A remote controlled system for remotely controlling a high load device, such as the defrosting cycle of a self-defrosting refrigerator, is provided. The system includes a data interface to receive commands from an electricity supplier and to transmit those commands via the power line to the refrigerator. The refrigerator is equipped with a power line interface to receive the commands from the power line and transmit the commands to a defrost sequencer. Between the power line interface and the defrost sequencer may be provided another interface that converts the commands into a digital signal more suitable for the defrost sequencer, which is typically a microprocessor.
Linear Image Processing Operations With Operational Tight Packing

Computer hardware with native support for large-bitwidth operations can be used for the concurrent calculation of multiple independent linear image processing operations when these operations map integers to integers. This is achieved by packing multiple input samples in one large-bitwidth number, performing a single operation with that number and unpacking the results. We propose an operational framework for tight packing, i.e., achieve the maximum packing possible by a certain implementation. We validate our framework on floating-point units natively supported in mainstream programmable processors. For image processing tasks where operational tight packing leads to increased packing in comparison to previously-known operational packing, the processing throughput is increased by up to 25%.
Twisted perovskites - control of spin and chirality in highly-luminescent metal-halide perovskites

The translation of chirality from molecular to bulk inorganic systems opens many possibilities for new phenomena. The properties of chiral electronic states are interesting scientifically and attractive for applications. While optoelectronic properties of semiconductors are controlled by charge, magnetic materials function by spin. If a material can combine these functionalities, powerful novel applications and large gains in performance are possible in opto-spintronics. Yet, existing magnetic semiconductors often show lower optoelectronic quality or work at low temperature. Development of new systems is a scientific challenge due to the required coordination of spins and control of physical properties of excited states, while minimizing defects.

TWIST will demonstrate novel highly-luminescent semiconductors for spin-control and chiral emission that show combined properties of ferromagnets and excellent semiconductors for efficient spin-LEDs at room temperature. To achieve this, TWIST will develop new approaches to control spin and chirality in doped metal-halide perovskites (MHPs) with magnetic elements and molecules, also in chiral superstructures.

In 2014, I reported that MHPs are exceptionally bright emitters, which underpins their tolerance to defects and chemical variation, and which recently enabled remarkable doping with transition-metals. Optical spin-control and chiral emission are possible from spin-orbit coupling and Rashba effects, which will enhance spin-order for Curie temperatures towards room temperature. These exceptional properties of MHPs, which have already produced efficient solar cells and LEDs, provide now a unique opportunity for my project.

TWIST will use state-of-the art optical and electronic techniques to unravel the fundamental mechanisms how magnetic moments, light and chiral states order and interact in MHPs. The results of TWIST will instigate opto-spintronic applications with novel functionality and lower energy consumption.
Deconstructing complexity to reveal quantitative systems-level principles that enable multicellular systems to coordinately regulate genes over space and time

A key question in biology is how cells at different locations communicate through signalling molecules so that cells at the right place and time turn on the right genes. Such coordination is vital for many processes including the development of all embryos. A common set of strategies that cells from distinct organisms use to coordinate their gene expression has long been elusive. Finding it requires quantifying how two key factors, the spatial locations of cells and the genetic circuits that control the cells’ secretion of signalling molecules, each affects cells' gene expressions. This has been challenging because their effects are often intertwined in complex ways.
 To overcome this challenge, I will assemble budding yeasts into multicellular structures component-by-component in a bottom-up manner, from building genetic circuits to arranging cells in space. I will build genetic circuits whose motifs commonly occur in natural systems. The yeasts will use the genetic circuits to control secretion and sensing of three distinct signalling molecules for communication. Using adhesive proteins and light-inducible genes, I will assemble multiple yeast strains, each with a unique genetic circuit, into a single two- and three-dimensional multicellular structure. The structures will mimic various sizes, shapes, and arrangements of cells found in nature. I will then switch on the circuits in these cells to initiate communication between cells. Different amounts of signalling molecules will cause the cells to make different amounts of fluorescent proteins. By measuring the fluorescence of cells at different locations over time and then correlating them, I will infer the degree of cell-cell coordination. I will build mathematical models to guide the experiments. By finding which combinations of genetic circuits and spatial arrangements of cells enable cell-cell coordination of gene expressions, I will reveal design principles of multicellular systems that have been elusive.
Modelling the Determinants of Malaysian Household Debt

This paper explores the determinants of household debt composition in Malaysia. By utilizing the bound test and Autoregressive Distributed Lag (ARDL) modelling approach, findings of this study reveals that in the long run period, a change in income level, housing price and population would have a positive impact on mortgage debt while rise in interest rates and cost of living would exert a negative influence. In addition, findings of this study supported that the household uses the debt as a substitute for income to finance the rising consumption as a result of a higher living cost. Findings of this study could provide some guidance to policymakers in controlling the mounting debt level and help in realizing the nation economic goals. Keywords: Household debt, Mortgage debt, Consumer debt, Bound test, Auto-regressive distributed lag (ARDL) modelling JEL Classifications: E00, E21, E31, E43, E51, G00
HIGH THROUGHPUT CHEMICAL SPECIATION

A system and method for high throughput chemical speciation of multi- component samples provides a two dimensional mapping of the samples. The two dimensions are operated in a high throughput method, with the first dimension being a high selectivity parallel extraction and the second dimension being a high resolution parallel or rapid-serial chromatographic step. The raw data can include acid strength and hydrophobicity, which is converted to a two dimensional view by data reduction techniques. The mapping is adjusted for non-proportional responses and multiple mappings can be combined to characterize a broader complex sample.
METHODS AND SYSTEMS FOR A SECURITY SURVEILLANCE SYSTEM WITH AN IMAGING DEVICE

A security surveillance system is provided. The system includes an imaging device configured to generate unprocessed digital image data and a control processor unit. The imaging device a lens, an imaging sensor that generates unprocessed analog image data, an A/D converter configured to digitize the unprocessed analog image data into unprocessed digital image data, and a communication interface configured to send unprocessed digital image data. The control processor unit is configured to receive the unprocessed digital image data from the communication interface and is configured to reconstruct an image from the unprocessed digital image data using an image reconstruction algorithm. The unprocessed analog image data includes compressively-sensed data in the form of analog voltage values that are based on light sensed by the imaging sensor.
Unified Treatment of Ideal Fermi, Bose, and Classical Gases

We give a unified treatment of ideal Fermi, Bose, and classical gases for temperatures sufficiently large that energy levels can be treated as a quasi-continuous. Sums can be converted to integrals over a density of quantum states to evaluate thermodynamic functions. Pressure is equal to two-thirds of the energy density for all three gases. Relevant integrals can be represented by series expansions if the absolute activity is less than unity, which is always the case for bosons. For fermions, larger values of the absolute activity can be handled by an asymptotic expansion. Virial expansions for the pressure of these ideal gases are power series in the ratio of the actual concentration to the quantum concentration. For absolute activity less than unity, the deviation from ideal gas behavior is practically linear in that ratio, less pressure for bosons, and more for fermions. Formulae for the heat capacity of these gases at constant volume are calculated in terms of several integrals.
Laser ablation: selectivity and monitoring for optimal tumor removal

Laser Ablation (LA) was extensively investigated for its benefits as minimally invasive thermal therapy for tumor. Despite the LA pros as potential alternative to surgical resection (e.g., use of small fiber optics, echo-endoscope procedures and image-guidance without artifact), the lack of tools for safe and patient-specific treatment restrained its clinical use. LASER OPTIMAL offers a renaissance to LA for the practical management of challenging tumors (e.g., pancreatic cancer): it investigates and develops integrated solutions to achieve an effective and selective LA, that thermally destroys the whole tumor mass, while spearing the normal tissue around. The excellent ambition of LASER OPTIMAL is to achieve and merge: a) biocompatible nanoparticles (BNPs) injected in the tumor, to enhance the selective absorption of laser light; b) patient-specific anatomy of tumor and its surrounding, extracted from clinical images, to retrieve the optimal laser settings; c) accurate, fast and real-time heat-transfer model to simulate laser-tissue-BNPs interaction, predict and visualize the treatment dynamics; d) real-time temperature measurement system to monitor LA effects, account for unpredictable physiological events and tune the settings (closed-loop). The design of ex vivo and in vivo animal tests allows assessing the system performances and driving the possible workflow re-design. Finally, human trials are envisaged to prove the significant impact of the LASER OPTIMAL paradigm. The collaboration of researchers, engineers and clinicians will drive the use of this innovative strategy in clinical routine. The research on the patient-specific system for the mini-invasive tumors removal, and the ground-breaking insights on clinical use of BNPs will strongly impact on EU healthcare system and society, by creating a novel product. This paradigm is also embeddable in existing system of industrial partner, extendable to other procedures, thus able to encourage a dedicated market.
Vibration Analysis of a Nonlinear System with a Nonlinear Absorber under the Primary and Super-harmonic Resonances (TECHNICAL NOTE)

Abstract   In vibratory systems, linear and nonlinear vibration absorbers can be used to suppress the primary and super-harmonic resonance responses. In this paper, the behavior of a nonlinear system with a nonlinear absorber, under the primary and super-harmonic resonances is investigated. The stiffnesses of the main system and the absorber are cubically nonlinear and the dampers are linear. Multiple time scales method is used to obtain approximate solution of the nonlinear equations of motion. Results show that at primary resonance, a linear absorber can suppress the peak amplitude of the system better than a non-linear one. But under super-harmonic resonance, the vibration amplitude can be more effectively reduced by adding a nonlinear absorber to the vibrating system.
Reconstituting Activism at the Borders of Contemporary South Africa

Debates about the meaning(s) of activism have been perennial preoccupations in post-authoritarian/undemocratic societies such as South Africa. There are those who insist that the attainment of formal political emancipation renders struggle and activism superfluous and anachronistic. Yet, the political realities of contemporary society have produced new struggles causing participants therein to argue for a resurrection of radical activism. In South Africa proponents of these divergent positions have used the anti-apartheid struggle as the primary historical reference to gain legitimacy. Both pivot on the crucial question of the appropriateness in a democratic South Africa of the kind of radical and popular activism that defeated white minority rule. With this in mind, how may one comprehend the evolution of activism in the unchartered terrain of formal democracy in South Africa? In this brief paper I intend to address this question by proposing that two dominant imaginings and practices of activism have taken shape, and although they have certain distinctive features, also share several common traits. An important arena in which each has been reconstituted over the past decade and a half has been the context of the creation of contentious local spaces and politics. This process has affected the potential for new forms of activism to transcend the ideological borders of the politics of parochialism and nationalism.
Thermo-electrochemical evaluation of lithium-ion batteries for space applications

Abstract Advanced energy storage and power management systems designed through rigorous materials selection, testing and analysis processes are essential to ensuring mission longevity and success for space exploration applications. Comprehensive testing of Boston Power Swing 5300 lithium-ion (Li-ion) cells utilized by the National Aeronautics and Space Administration (NASA) to power humanoid robot Robonaut 2 (R2) is conducted to support the development of a test-correlated Thermal Desktop (TD) Systems Improved Numerical Differencing Analyzer (SINDA) (TD-S) model for evaluation of power system thermal performance. Temperature, current, working voltage and open circuit voltage measurements are taken during nominal charge–discharge operations to provide necessary characterization of the Swing 5300 cells for TD-S model correlation. Building from test data, embedded FORTRAN statements directly simulate Ohmic heat generation of the cells during charge–discharge as a function of surrounding temperature, local cell temperature and state of charge. The unique capability gained by using TD-S is demonstrated by simulating R2 battery thermal performance in example orbital environments for hypothetical extra-vehicular activities (EVA) exterior to a small satellite. Results provide necessary demonstration of this TD-S technique for thermo-electrochemical analysis of Li-ion cells operating in space environments.
Effect of the maize–soybean intercropping system on the potential bioavailability of magnesium, iron and zinc

This study concerned the effect of different intercropping systems (alternating rows and alternating strips) of maize and soybean compared with single cropping, in combination with different fertilisers (biofertiliser, organic fertiliser, and urea) on the potential availability of magnesium (Mg), iron (Fe) and zinc (Zn) from grain, through their ratio with phytate (as inhibitor) and β-carotene (as promoter). The higher grain yield and land equivalent ratio obtained under alternating rows + biofertiliser treatment demonstrated the improved ability of crops in close proximity for better utilisation of existing agro-ecological conditions. Alternating rows + organic fertiliser decreased the molar ratios phytate : β-carotene, phytate : Fe, phytate : Mg and phytate : Zn, indicating increased availability of the mineral elements in both crops. However, alternating strips + organic fertiliser contributed mostly to an increase in β-carotene, Mg, Fe and Zn concentrations in soybean. Increased grain yield of both crops was followed by decrease in β-carotene and increase in phytate, particularly in maize. In soybean, β-carotene could be considered as the main contributor to Fe availability. Accordingly, cropping in alternating rows or strips, combined with biofertilisers, could serve as fortification measures for improved nutritional quality of maize and soybean grain, without grain yield losses.
Motivation of the Participants Involved in Marine Sports Emotional Impact of Exercise

Motivation of participants in this study were marine sports movement through the emotional impact of these participants can continue to take advantage of marine sports, and at the same time looking for ways to stabilize participants' emotions and mental exercise to find ways to enable identifying emotions purpose is to provide basic information. In order to achieve these objectives May to October 2013 review of research results obtained are as follows. First, marine sports participation motivation of the participants involved in the relationship between emotion and motivation exercise fun, and when the external, physica l health, social, physical condition, emotional fulfillment and exercise all the sub-factors and the significant positive correlation with that of thes howed, nomotivation and vitality are significant negative relationship with, respectively. Second, the participant's participation in marine sports exercise emotional impact on motivation Motivation is a fun look at the impact on the results of this condition, fulfillment, health and physical fitness showed the vitality of the social, achievement, condition, pleasure, respectively. And when the external purification, social, achievement, health and physical fitness showed as, fulfilling the condition, social, health and physical fitness, a sense of accomplishment as appeared, pride of accomplishment, social, physical condition, pleasure, showing off the external influence.
On-Board Orbit Propagator and Orbit Data Compression for Lunar Explorer using B-spline

In this paper, an on-board orbit propagator and compressing trajectory method based on B-spline for a lunar explorer are proposed. An explorer should recognize its own orbit for a successful mission operation. Generally, orbit determination is periodically performed at the ground station, and the computed orbit information is subsequently uploaded to the explorer, which would generate a heavy workload for the ground station and the explorer. A high-performance computer at the ground station is employed to determine the orbit required for the explorer in the parking orbit of Earth. The method not only reduces the workload of the ground station and the explorer, but also increases the orbital prediction accuracy. Then, the data was compressed into coefficients within a given tolerance using B-spline. The compressed data is then transmitted to the explorer efficiently. The data compression is maximized using the proposed methods. The methods are compared with a fifth order polynomial regression method. The results show that the proposed method has the potential for expansion to various deep space probes.
LEUCO POLYMERS AS BLUING AGENTS IN LAUNDRY CARE COMPOSITIONS

A method of obtaining a laundry care composition, the method comprising the steps of (a) reacting a reactive leuco compound with a polymer to form a leuco polymer and (b) mixing the leuco polymer with at least one laundry care ingredient. The reactive leuco compound comprises at least one leuco moiety and at least one nucleophilic group. The polymer comprises at least one group capable of reacting with said nucleophilic group. The leuco moiety has a maximum molar extinction coefficient at a wavelength in the range 400 to 750nm of less than 1000 M-1cm-1.