SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
A phase II, randomized, open-label 3-arm clinical trial of fulvestrant (F) plus goserelin (G) versus anastrozole (A) plus goserelin (G) versus goserelin (G) alone for hormone receptor (HR) positive, tamoxifen (T) pretreated premenopausal women with recurrent or metastatic breast cance r(MBC) (KCSG BR10-04).

1041 Background: Endocrine therapy(ET) is the preferred treatment for HR(+) MBC. For premenopausal patients who were pretreated with T, ovarian function suppression with G ± aromatase inhibitor(A.I.) is a reasonable option. Fulvestrant yields favorable outcomes in postmenopausal women with MBC. We investigated the efficacy and safety of F+G and A+G in comparison with G alone in premenopausal women with HR(+), T-pretreated MBC. Methods: In this multicenter, open-label, randomized phase 2 study, women &gt; 18 years with HR(+), T-pretreated MBC were stratified by presence of visceral metastasis and recurrence within or after 1 year of completion of adjuvant T. Premenopausal women with T-pretreated MBC eligible for ET were randomly assigned (1:1:1) to F+G (F 500 mg IM + G 3.6 mg SC Q 4 wks), or A +G (A 1 mg P.O. qd + G 3.6 mg SC Q 4 wks) or G (G 3.6 mg SC Q 4 wks). The primary endpoint was time to progression(TTP), analyzed by intention to treat with log-rank test. Secondary endpoints included overall survival, overall response rate, clinical benefit rate and toxicities according to NCI CTCAE v3.0 (ClinicalTrials.gov, No. NCT01266213). Results: Of 138 eligible pts, 44 were randomly assigned to F+G, 47 to A+G, 47 to G. The median duration of follow-up was 28.8 months(mo) and median age was 43 (range; 23.0-55.0). The median TTP was 16.3 mo(95% C.I. 7.5-25.1) for F+G, 14.5 mo(95% C.I. 11.0-18.0) for A+G, and 13.5 mo(95% C.I. 10.3-16.8) for G alone, respectively. For the comparison of each experimental arm to control arm, 24-mo TTP were analyzed: F+G vs G(%±SE): 40.5±7.5 vs. 25.3±7.0, one-sided P = 0.048, A+G vs G(%±SE): 23.9±7.2 vs. 25.3±7.0, one-sided P = 0.304. Grade 3/4 toxicities were rarely observed. Most common adverse events were grade 1 joint stiffness and arthralgia which were more frequently observed in F+G compared to A+G and G (P = 0.018 and 0.015, respectively). Conclusions: The combination of F+G as well as G ±A.I. might be a valid option for HR(+) premenopausal women with T-pretreated MBC and further investigation is warranted. Clinical trial information: NCT01266213.
China’s “Antiaccess” Ballistic Missiles and U.S. Active Defense

Relations between Taiwan and China have improved recently. At the same time, U.S.-Japanese relations have worsened, partly as the result of disagreements over Futenma Marine Air Station on Okinawa. As a result, the prospects of fighting between the United States and China over Taiwan and of U.S. reliance on Okinawa bases to supplement carrier airpower in the course of such a fight appear far-fetched, disastrous for the states concerned. Of course, military professionals and the defense analytic community need to think through unlikely and unwelcome scenarios. To that end, various analysts have contributed to a lively discussion of Chinese “antiaccess” systems designed to keep the United States at bay in the event of conflict. These systems include C4ISR (command, control, communications, computers, intelligence, surveillance, and reconnaissance) assets like over-the-horizon (OTH) radar and increasing numbers of satellites, a more modern air force, more submarines with better weapons, and both cruise and ballistic missiles to hold at risk our ships at sea and our air bases ashore. This article examines ballistic missile threats to carriers and air bases and the adequacy of U.S. active defenses. China seeks the capacity to find U.S. aircraft carriers roughly a thousand miles from the mainland and to attack them with homing ASBMs (antiship ballistic missiles). China must overcome serious technological challenges to field the systems needed to do these things. The United States faces the prospect that Marshall Hoyler, now retired, was a professor at the Naval War College from 2001 through 2008. Before becoming a teacher, he worked as a defense analyst at the Congressional Budget Office, the Center for Naval Analyses, and the Institute for Defense Analyses. Prior to that, he was a rifle platoon leader in the 3rd Battalion, 9th Marines.
PolyTop++: an efficient alternative for serial and parallel topology optimization on CPUs &amp; GPUs

This paper presents the PolyTop++, an efficient and modular framework for parallel structural topology optimization using polygonal meshes. It consists of a C++ and CUDA (a parallel computing model for GPUs) alternative implementations of the PolyTop code by Talischi et al. (Struct Multidiscip Optim 45(3):329---357 2012b). PolyTop++ was designed to support both CPU and GPU parallel solutions. The software takes advantage of the C++ programming language and the CUDA model to design algorithms with efficient memory management, capable of solving large-scale problems, and uses its object-oriented flexibility in order to provide a modular scheme. We describe our implementation of different solvers for the finite element analysis, including both direct and iterative solvers, and an iterative `matrix-free' solver; these were all implemented in serial and parallel modes, including a GPU version. Finally, we present numerical results for problems with about 40 million degrees of freedom both in 2D and 3D.
VAPOR DEPOSITION METHODS OF SiCOH LOW-K FILMS

Disclosed are precursors that are adapted to deposit SiCOH films with dielectric constant and Young's Modulus suitable for future generation dielectric films.
Method of forming identifying indicium on cathode ray tubes

A method for forming an identifying indicia on a cathode ray tube being manufactured, which method is practiced by applying a paint containing a powdered metal to a particular exterior surface portion of a glass envelope, forming a part of the cathode ray tube, to form a solid paint layer, followed by the radiation of a laser beam onto at least a portion of the solid paint layer to form the identifying indicia represented by at least one trace of plasticized deformation on a surface region of the solid paint layer.
Comparison of fast correlation algorithms for target tracking

Laser Aided Detection and Ranging (LADAR) imaging systems can be used to provide high resolution
imaging and tracking of moving targets at night. Central to the tracking system is a high speed correlation
algorithm to determine target motion between sensor image frames. Several issues complicate the
correlation calculations. These include coherent speckle noise and atmosphere induced scintillation of the
illuminator beam. The Fitts correlation algorithm is commonly used because of its simplicity and speed.
However it is only optimal when the shift between sensor frames is less than a pixel. In addition it can be
sensitive to certain types of noise. Projection based phase only (PBPO) is another type of correlation
algorithm that is also high speed and in many cases less sensitive to noise. In this paper we compare the
Fitts algorithm with PBPO in terms of number of computations and noise immunity when used in a
LADAR tracker.
Local Opportunities for Negative Emission Technologies and their Applications

Negative emissions technologies (NETs) are the true new frontier of the European environmental policy. Early-stage carbon capture technologies are being studied, tested and piloted all over the world, quickly gathering global attention as an important component of the complex pathway toward carbon neutrality. Their development has a huge economic potential, recently estimated in 190 billion USD / year for the US. Their implementation requires close cooperation between technical innovators, industrial sector, and public administration, who has control over land, forestry, water basins, coastal and marine zones and other vital assets. 

Both Montenegro and Albania have shown significant progress in their environmental policy over the last few years according to their periodical negotiation assessments [European Commission, 2018]. On the other side of the sea, Puglia is a very atypical EU lagging region, where radical - even pioneering - innovations and future emerging technologies find a welcoming environment.

Joining efforts with the successful experience of INERRAnT (2018-2020 project co-financed by Interreg IPA CBC), and MARINE, LONETA will explore opportunities and challenges of negative emission technologies for SMEs and start-ups, thanks to a strong partnership between the academic world, the industrial organizations, and the public administrations. Our work will lead to the first Memorandum of Understanding for the NETs in the South Adriatic area, and to the implementation of a strong advocacy action toward local institutional and economic players.

LONETA is designed according to a ‘nudge’ methodology. We aim at creating a reciprocal and self-sustainable partnership between Puglia, Albania, and Montenegro, contributing to the 2050 Strategy for a Climate Neutral Europe and to the 2030 Sustainable Development Goals, by fostering early-stage and pilot investments on negative emissions technologies in the programme area.
Optimal power utilizing strategy for PV-based EV charging stations considering Real-time price

Developing EVs has been established as an effective way to reduce carbon emission in development and ensure energy security by many countries. The PV-based EVCS (EV charging station) can efficiently alliviate the charging pressures of the distribution network and reduce EVs indirect emissions. A Real-time power utilizing strategy considering real-time price for PV-based EV charging station is proposed to allow EVs to participate in DR (Demand Response) and charge economically. The DR is adopted for power utilizing strategy to offer a kind of financial benefits for EVs and minimize the charging fees. The behavior mode and the CRFR mode are utilized to figure out the EV demand mode. The PSO (Paticle Swarm Optimal) algorithm is utilized to optimally allocate the charging power. The real-time price is forecasted by wavelet neural network based on the historical data and the total charging power responses to the real-time price so as to minimize charging cost. A case study is simulated to validate the proposed method.
RESERVOIR DISTRIBUTION AND DIAGENESIS IN THE NORTHERN NORTH SEA BASIN

Reservoirs in the northern North Sea Basin range from fractured basement to Eocene deposits.There are five sets of main reservoirs:① the Permian Rottiegeudes aeolian and/or alluvial sandstones;②the Triassic fluvial sandstone;③the Middle and Lower Jurassic fluvial,deltaic and marginal marine sandstone;④the Upper Jurassic shallow marine and deep marine turbidite sandstone and conglomerate;⑤the Upper Cretaceous-Lower Paleocene chalk and Paleocene deep-sea turbidite fan sandstones.It is found that the Paleocene-Eocene sandstone is weak in diagenesis and permeability becomes lower under 3100 m.The dissolution of K-feldspar is a major factor influencing diagenesis and permeability in the shallower part.Then illite becomes the main factor below about 3700 m,and secondary quartz plays a major role in the sequence below 4000 m.Oil and gas accumulation depends on the distribution pattern of reservoirs.
Quantum Theory of Solid State Plasma Dielectric Response

We review the quantum mechanical derivation of the random phase approximation (RPA) for solid state plasmas, starting from the Hamilton equations for canonically paired “second quantized” creation and annhilation field operators of interacting quantum many-body systems. Discussing variational differentiation, the coupled equations of motion for the quantum field operators are derived. The concept of Green's functions is reviewed and interpreted, first for retarded Green's functions, and their equations of motion are developed from the equations of motion for the field operators. Thermodynamic Green's functions are discussed, and their periodicity/antiperiodicity properties in imaginary time are carefully examined with discussion of Matsubara Fourier series and representation in terms of a spectral weight function. The analytic continuation from imaginary time to real time is treated. Finally, we define nonequilibrium Green's functions and discuss the linearized timedependent Hartree approximation leading to the random phase approximation. An interesting application to the case of Graphene in a perpendicular magnetic field is discussed in detail, along with applications to normal systems, in terms of attendant phenomenology involving electron-hole pair excitations and plasmons (© 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim)
Photo-Piezo-Actuators based on light sensitive composite

PULSE-COM aims to explore technological breakthroughs developing and integrating a new class of Photo-Piezo-Actuators to open a radical new future technology.  Our vision is based on the use of low cost photo-mobile polymer (PMP) films and a lead-free piezo-composite (PZL) to target their use in innovative new fields never before considered. Starting from phenomenological and modelling aspects of the composite materials, we will fabricate and experimentally characterize Photo-Piezo-Actuators (PMP-PZL) proof of concept devices. The project will address through an ambitious interdisciplinary research to the employment of proper materials and the appropriate optical strategies to increase and tune the absorption of the light and finally to increase the PMP devices efficiency. With the same target electromechanical models and innovative growth processes will guide the optimization of the piezocomposite to improve its performance, and thus its sensitivity when coupled with the PMP. The PMP-PZL device will be integrated into more complex opto-electronic systems through high-risk incremental research to achieve pioneering industrial implementation. Specifically, we target the realization of cutting-edge applications based on photo-activated Meso-scale machines as opto-switches and opto-microvalves, Reconfigurable Optics and Photoenergy Harvesting Systems. Our study can open a new window on the future development of light-driven nanomotors and their potential applications in different areas such as biomedical, environmental and nanoengineering fields.
Arthrose et incidence des accidents vasculaires cérébraux et des accidents ischémiques transitoires chez 320 136 adultes suivis dans des cabinets généralistes au Royaume-Uni

Resume Objectif Cette etude avait pour objectif d’explorer la relation entre l’arthrose et l’incidence des accidents vasculaires cerebraux (AVC) et des accidents ischemiques transitoires (AIT) au Royaume-Uni. Methodes L’etude a inclus des patients ayant recu un diagnostic initial d’arthrose dans l’un des 256 cabinets de medecine generale du Royaume-Uni entre 1997 et 2016 (date index). Des patients sans arthrose ont ete apparies (1:1) aux patients avec arthrose selon des scores de propension fondes sur le sexe, l’âge, l’annee index, le cabinet generaliste et les facteurs de risque vasculaire consignes dans les 12 mois precedant la date index (hypertension, obesite, diabete sucre, dyslipidemie et fibrillation atriale). Pour les patients sans arthrose, une date de consultation aleatoire entre 1997 et 2016 a ete selectionnee comme date index. La relation entre l’arthrose et l’incidence des AVC et AIT a ete analysee au moyen de courbes de Kaplan-Meier et de regressions de Cox. Resultats Cette etude a inclus 160 068 patients atteints d’arthrose et 160 068 patients sans arthrose (61,6 % de femmes, âge moyen [ecart-type] 64,2 [14,2] ans). L’incidence a 10 ans des AVC (4,5 % contre 3,0 %) et des AIT (3,3 % contre 2,0 %) etait significativement plus elevee chez les patients avec arthrose. Les analyses de regression de Cox ont egalement fait apparaitre une association positive entre arthrose et AVC (hazard ratio [HR] 1,45, intervalle de confiance [IC] a 95 % 1,39–1,51) et AIT (HR 1,55, IC 95 % 1,47–1,63). Conclusions Ces observations suggerent une possible association de l’arthrose avec une augmentation de l’incidence des AVC et des AIT. Des etudes longitudinales complementaires sont necessaires pour confirmer ou infirmer ces resultats.
New species and new records in Neoibidionini and Hexoplonini (Coleoptera: Cerambycidae: Cerambycinae)

Four new species are described in Neoibidionini (Compsina): Corimbion wappesi, from Guatemala, Zacapa; Neocompsa pilosa, from Paraguay, Itap Neocompsa soniae, from Panama, Chiriqu and Heterachthes boliviensis, from Bolivia, La Paz. New country record, Trinidad and Tobago, as well as chromatic and morphological variations are reported to Gnomidolon incisum Napp Martins, 1985 (Hexoplonini), and Compsibidion vandenberghei Heffern, Santos-Silva Nascimento, 2018 (Neoibidionini, Neoibidionina). Additionally, a key to species of Corimbion Martins, 1970 are provided, and the two new species of Neocompsa Martins, 1965, and the new species of Heterachthes Newman, 1840 are included in a previous key.
Steigerung der Produktionskapazität und Stärkung des Exportpotenzials von Electrostart JSC

Electrostart JSC ist das einzige Unternehmen in Bulgarien für die Herstellung von Vorschaltgeräten für Leuchtstoff-, Natrium-, Quecksilber- und Metallhalogenlampen. (Die Rosle ist eine Spule mit einer Magnetpipeline. Gegründet als Staatswerk in der Stadt Varshets, Bezirk Montana 1967, wurde Elektrostart 1993 als Aktiengesellschaft registriert und wurde für seine 22-jährige neue Geschichte zu einem der größten und am schnellsten wachsenden Privatunternehmen auf der Balkanhalbinsel. Die Produkte von Electrostart werden vollständig in der Beleuchtungsindustrie als Komponenten verwendet, die in Beleuchtungseinrichtungen von Unternehmen integriert sind, die Design und Konstruktion von Beleuchtungsanlagen für Straßenbeleuchtung, Innenbeleuchtung, Industriebeleuchtung, Architektur, Parkbeleuchtung, Sporthallen und Stadien und andere anbieten: •Fluorescent-Leuchten •Transformer •Drossel für Gasentladungslampen •Gasentladungslampenkits •Illuminationsgeräte •Elektronische Drosseln • Elektronische Bohrer • Elektronische Bohrer • Elektronische Bohrer • Elektronische Bohrer • Elektronische Bohrer • Elektronische Bohrer • Elektronische Bohrer • Elektronische Bohrer • Elektronische Bohrer • Elektronische Bohrer • Elektronische Bohrer • Elektronische Bohrer • Elektronische Bohrer • Elektronische Bohrer • Elektronische Bohrer • Elektronische Bohrer • Elektronische Bohrer • Elektronische Bohrer • Elektronische Bohrer • Elektronische Bohrer • Elektronische Bohrer • Elektronische Bohrer • Elektronische Bohrer • Elektronische Bohrer • Elektronische Bohrer • Elektronische Bohrer • Elektronische Bohrer • Elektronische Bohrer • Elektronische Bohrer • Elektronische Bohrer • Elektronische Bohrer • Elektronische Bohrer • Elektronische Bohrer • Elektronische Bohrmaschinen • Elektronische Bohrmaschinen • Elektronische Bohrer • Elektronische Bohrer • Elektronische Bohrer • Elektronische Bohrer • Elektronische Bohrmaschinen • Elektronische Bohrmaschinen • Elektronische Bohrer • Elektronische Bohrer • Elektronische Bohrer • Elektronische Bohrmaschinen • Elektronische Bohrer • Elektronische Bohrer • Elektronische Bohrer • Elektronische Bohrer • Elektronische Bohrer • Elektronische Bohrer • Elektronische Bohrer • Elektronische Bohrer • Elektronische Bohrer • Elektronische Bohrer • Elektronische Bohrer • Elektronische Bohrer • Um unsere strategischen Entwicklungspläne zur Steigerung der Produktivität und zur Steigerung der Produktionsmengen für aktuelle und neue Kunden umzusetzen, planen wir die Umsetzung dieses Projekts, einschließlich Maßnahmen zur Verbesserung der Produktionsprozesse und Aktivitäten zur Umsetzung neuer Technologien zur Verbesserung der Ressourceneffizienz und Effizienz im Produktionsprozess. Die Projektaktivitäten werden durch den Kauf und die Inbetriebnahme der ausgewählten notwendigen Ausrüstung durchgeführt. Das Projekt zielt darauf ab, die Wettbewerbsfähigkeit von Electrostart JSC zu erhöhen, indem die Produktionskapazität erhöht und das Exportpotenzial des Unternehmens gestärkt wird.
ADJUSTING CURRENT LIMIT THRESHOLDS BASED ON OUTPUT VOLTAGE OF POWER SUPPLY DEVICE IN SYSTEM FOR PROVIDING POWER OVER COMMUNICATION LINK

A power supply system for providing power over a communication link has current limit circuitry for restricting an output current of the system based on a current limit threshold, and threshold circuitry for setting the current limit threshold in accordance with an output parameter of the system. In particular, the threshold circuitry may control the current limit threshold in accordance with an output voltage of the system so as to achieve a substantially constant output power of the system.
Development of special carousel parking systems

The main subject of this project is the development and production of the second generation prototype carousel parking system. The subject of the development will be the modification of electronics and implementation of the charging system for electric vehicles, development of the control system for the charging system and analysis of other possibilities of use and innovation. The project will include exploration of battery systems, research on charging characteristics, development of solutions and proposals for placing batteries in a suitable location. Place of implementation: Otmarov 123, 664 57 Otmarov.
Violence in John Steinbeck

Suicides; domestic violence; lynching; botched abortions; fraternal beatings; heroes who boast about knocking people’s heads “plumb to squash” (The Grapes of Wrath, 28) merely a cursory glance at Steinbeck’s writing reveals the central presence of violence. Brutal force is never far from the surface of a Steinbeck story. Here I want to argue that there exists a deep tension between two different “presentations” of violence. One which naturalizes violence. The other according to which violence remains aberration, absolute wrong, that which should not be. These two presentations are in competition, vying with each other for control of his texts. You may share the academy’s historic disdain for Steinbeck’s style. Or you may agree with Kurt Vonnegut that “Holy smokes! Could he ever write!” (John Steinbeck: Centennial Reflections by American Writers 96). Either way, what is certain is that violence evokes some of his best writing.
Synthesis of new glycosaminoglycans-like families by regioselective oxidation followed by sulphation of glucoglucuronan from Rhizobium sp. T1

Glycosaminoglycan-like polysaccharides were prepared from Rhizobium sp. T1 polysaccharide using the TEMPO (nitroxyl radical 2,2,6,6-tetramethylpiperidine-1-oxyl radical) mediated oxidation. The structure of this new polyglucuronic acid sodium salt was analyzed by (13)C NMR spectra and HPAEC-PAD chromatography. Therefore, new polysaccharide containing only glucuronic acid monomers in both β-(1,3) and β-(1,4) linkage was obtained by the complete TEMPO-mediated oxidation of C6 primary hydroxyl groups of glucose of glucoglucuronan from Rhizobium sp. T1. Sulphation of this β-(1,3),β-(1,4)-polyglucuronic acid sodium salt was carried out using SO3/DMF reagent. These results suggested a new synthetic route using both TEMPO-mediated oxidation and sulphation of polysaccharides from Rhizobium sp. in developing glycosaminoglycans mimic to enhance the profitability of its low-cost production and processing industries. This novel carbohydrate derivative might find use as cheaper surrogates of glycosaminoglycans in the cosmetics and pharmaceutical fields.