SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Immune directed and cancer-selective immunotherapy

I-DireCT is a European Industrial Doctorate (EID) training network designed to provide training and carry out breakthrough research on the rapidly expanding and high impact field of cancer immunotherapy in a carefully integrated academic and inter-sectoral programme. Hereby, we aim to develop next-generation immunotherapeutics and deliver a set of early stage researchers uniquely qualified for a career in academia and/or industry.

Current immunomodulatory antibodies that target pivotal immune checkpoints have revolutionized the field of oncology. However, off-tumor activity limits their application. The objective of I-Direct is to address this issue by 1. developing innovative bispecific antibodies and immunocytokines with tumor-restricted immunostimulatory effects and 2. developing optimized delivery systems to ensure optimal timed release of bio-active drug. Hereto, I-DireCT combines state-of-the-art industrial design of nanotech-based drug formulations with innovative academic and industrial immunotherapeutic concepts into the next-generation of cancer immunotherapeutics.

At the core of I-DireCT is its training objective to offer a cutting-edge multidisciplinary training programme that will enable outstanding young scientists to generate breakthrough ideas and assume leading positions in academia and industry. This training programme includes an array of disciplines, ranging from biomedical sciences (e.g. immunology, antibody engineering) and physical sciences (e.g. chemistry, material science) to drug design & development.

Industrial partners are central to the programme and provide pivotal inter-sectoral expertise on how to translate scientific discoveries into commercial reality, with each ESR being appointed at an inter-sectoral partner for 18 months, as well as through additional secondments. Further, I-Direct will enable long-term multi-disciplinary research and fosters bilateral co-operations between academia and industry.
A 4000-meter-rated deepwater cabled ocean observing system: Lessons learned from two years of operation

In recent years, there have been several major initiatives to install fiber-optic cabled ocean observatories in the United States, Canada, Japan, and Europe. Lighthouse has operated a fiber-optic cabled ocean observing system off the northern coast of the Sultanate of Oman for seven years: the Lighthouse Ocean Research Initiative (LORI) I. In early 2010, a second cabled system was installed farther to the south, LORI II. LORI II is comprised of three, 2500-m-long moored arrays each equipped with eight Doppler current profilers and additional environmental sensors. The moorings sit along the 3000 m bathymetric line, so the uppermost current Doppler profiler uses a low frequency (75 kHz) to capture velocities and acoustic backscatter for the uppermost 500 m of the water column. Lighthouse had significant experience operating a cabled array in shallower water (<;1350 m) and had deployed and recovered autonomous arrays from the same locations as the cabled LORI II instruments several times in the past and thus confidence was high the system would operate as installed. After deployment, the quality of the raw data was very good with nearly all of the installed sensors reporting; but by year two, communication with two of the moorings had been lost. The cause of the problem has been tentatively identified. Herein, we discuss the research, development, installation, and operation of LORI II over the past two and a half years, scientific results from LORI II data, and the lessons learned from seven years of successful operation of the LORI I cabled system, all of which will be incorporated in a new-and-improved, science-driven, cabled LORI II design.
Isotope variability in water vapor over Southern California

Variations in the ratios of different isotopes of hydrogen and oxygen in water have long been used to trace water cycle processes, and the isotopic composition of water vapor in the atmosphere is known to change with weather events. Farlin et al. measured the isotopic composition of atmospheric water vapor in San Diego, Calif., at hourly intervals during February 2011 using a ground-based sensor. The time period included severe rainstorms and Santa Ana winds. They also used a general circulation model that included simulation of isotope variability to investigate how atmospheric and hydrologic processes affect isotope composition of water vapor near the surface.
Translational approaches to disease modifying therapy of type 1 diabetes - harvesting the fruits of innodia

Building on the strong foundations of INNODIA, with its unique, Europe-wide clinical and basic research network for the study of type 1 diabetes (T1D), we propose in INNODIA HARVEST an ambitious program which aims to prevent and arrest T1D via focused objectives targeting consolidation and innovation. First, we will consolidate the INNODIA clinical network as the reference point for conducting studies to prevent or arrest T1D. We will transform our standardized clinical and bioresource platforms into a high-performance clinical trial network, running academic and industry-driven trials alongside small, mechanism-centric, biomarker-rich intervention trials to examine pathobiological pathways to T1D. INNODIA HARVEST will conduct two large studies to arrest T1D at its onset, one academia-driven, beta-cell focused (VER-A-T1D, verapamil) and one industry-driven, immune-focused (Iscalimab-study). We will exploit our original INNODIA Master Protocol allowing novel adaptive trial design to introduce combination therapies that build on complementary mechanisms. Second, we will extend our study design strategy by introducing novel biomarkers, both clinical (continuous glucose monitoring) and experimental (microbiome analysis) to deconvolute disease heterogeneity and identify new endpoints to accelerate identification of effective therapeutics. Third, we will use ‘disruptors’ in small mechanistic studies to channel innovation from clinic to basic research through a reverse immunology and reverse beta-cell biology approach. Finally, we will implement new discovery pipelines for future therapeutics, exploiting tools such as iPSC-derived islet-like cells to promote next generation target identification and drug development. As in INNODIA, the voice of people living with T1D and their families will hold a central place in INNODIA HARVEST to drive implementation of new, patient-proximal outcomes, shape our clinical trials, and bring about a meaningful change in disease perspective.
A major objective of INNODIA Harvest is the execution of at least two new phase 2 trials (studying Verapamil (VER-A-T1D) or Iscalimab (CCFZ533X2207)). Considering the expected time to first patient-in as preparations for trial start can only be initiated after the start of the Action and possible fluctuating recruiting rates, due to the intercurrent COVID epidemic, there is a risk that INNODIA HARVEST will not be able to completely finalize the clinical trials, fully analyse the biomarkers collected and publish the results in the initially proposed 24 months duration. To ensure the finalization of the clinical trials and corresponding full execution of the given budget including eligibility of EFPIA in-kind contribution we propose to extend the duration of the Action from 24 to 36 months.
Human-Nature Interactions in the Anthropocene

List of Figures. List of Tables. Foreword by the Chair of the Scientific Committee of the Earth System Science Partnership (ESSP) and Professor in Environmental Systems Analysis, Wageningen University Rik Leemans Preface by the President of the German Society for Human Ecology (DGH) and Scientific Steering Committee Member of the Land-Ocean Interactions in the Coastal Zone (LOICZ) Bernhard Glaeser. Acknowledgments. Part I: Introduction 1. New Approaches to the Analysis of Human-Nature Relations Marion Glaser, Beate M.W. Ratter, Gesche Krause and Martin Welp 2. Systems Thinking and Social Learning for Sustainability Gesche Krause and Martin Welp Part II: Social-Ecological Systems (SES) and Complexity 3. Social-Ecological Systems as Epistemic Objects Egon Becker 4. Modelling Social-Ecological Systems: Bridging the Gap Between Natural and Social Sciences Felix Tretter and Andrew Halliday 5. Complexity and Emergence: Key Concepts in Non-Linear Dynamic Systems Beate M.W. Ratter Part III: Resilience, Adaptability and Transformability 6. Archetypes of Adaptation to Climate Change Klaus Eisenack 7. Population Dynamics and Adaptive Capacity of Supply Systems Diana Hummel Part IV: Multi-Agent Modelling and Simulation 8. Transdisciplinary Multi-Agent Modelling for Social-Ecological Systems Analysis: Achievements and Potentials Marion Glaser 9. Integrated Modelling and Scenario Building for the Nicobar Islands in the Aftermath of the Tsunami Martin Wildenberg and Simron Jit Singh Part V: Pathways Towards New Systems Thinking in Human Ecology 10. Towards Global Sustainability Analysis in the Anthropocene Marion Glaser, Gesche Krause, Andrew Halliday and Bernhard Glaeser. Contributors. Index.
The oldest and the rarest - combining insight from both hemispheres to gain a global picture of baleen whale origins and macroevolution

Baleen whales (Mysticeti), the largest animals on earth, are a spectacular example of evolutionary adaptation and, as predators and nutrient distributors, a major component of the modern ocean ecosystem. Their relatively good fossil record, large ecological impact and the existence of extant species as a source of comparative data make mysticetes an ideal macroevolutionary case study – promising fundamental insights into the interaction between biodiversity, evolution, and the physical environment. Previous research into the mode and tempo of baleen whale evolution has been hampered by a historical data bias towards the Northern Hemisphere, poor taxon sampling, and disjunct methodologies. I propose to address these issues through (1) targeted sampling of Southern Hemisphere fossil material to create the most comprehensive and most balanced dataset on mysticete morphology to date; (2) the application of cutting-edge phylogenetic methods, including new Bayesian techniques to simultaneously infer phylogeny, divergence dates, evolutionary rates and ancestral body size; (3) reconstructing past mysticete diversity, disparity (morphological diversity) and shifts in their rate of diversification, as well as ancestral geographic ranges and dispersal patterns; and (4) integrating all available data and results with palaeoenvironmental proxies to test whether mysticete evolution has been driven by environmental change. This project will create a benchmark for future studies as one of the most comprehensive and multifaceted macroevolutionary syntheses for any major vertebrate clade, and provide profound insights into evolutionary processes and the workings of the marine ecosystem.
Techniques for the promotion of the cultural heritage

In the past culture was regarded as part of the “public” heritage, but today it is becoming more and more of a “product” subject to the laws of the market. In this sense, cultural enterprises are undergoing great changes, due to a number of factors that have led to the rethinking of the role of marketing in this field. The objectives of cultural policies today - through a marketing-oriented approach to arts and culture in their widest sense - are far-reaching and regard both the traditional aspects of the preservation of the artistic and historical heritage and the accessibility and fruition of the heritage for a greater number of consumers. This vast range of objectives goes beyond preservation and safeguarding, to encompass the innovation processes that are afoot in this sector. In this sense, this project intends to train the professional figure of the cultural manager, i.e. the person in charge of communication and marketing activities for a cultural enterprise, who works in a cross-border context with the aim of enhancing its culture and tradition through the adoption of multimedia or hypermedia techniques. In the framework of this project special emphasis is placed on the definition of a common method to catalogue the cultural heritage both in Italy and Slovenia, which translates into the production of a multi-lingual and multimedia thesaurus.
The Theoretical and Practical Relationship of Ergonomic: The Study of Professionals Involved in Foreign Trade on Port System

Abstract The Brazilian foreign trade has long been closed due to internal protection of domestic industry, resulting in kicking and technological sophistication. From the fall of the military regime in Brazil and the establishment of a democratic regime in the decade 90, the government reopened the external commercial relations. With the growth of globalization was the increase of foreign trade professionals in ports of ships, resulting in the need to improve machinery resources, technological, professional improvement, implementation procedures and port safety rules and conditions at work in this area. The research in question aims to relate a theoretical study using based NR 29 (Regulatory Norm) Brazilian, checking in practice, the actual use of it on a port which has large volume of daily loads drives in Southern Brazil, considered the second largest terminal in South America containers. the data collection was through quantitative and qualitative research and through observation in port professionals. It is still possible to observe through the results gained from this research that the port professionals working conditions require considerable attention due to the large flow of operations by the end loading and unloading of your daily routine. We have detected that in Brazil there is a great deficiency in the supply of port infrastructure level in question, and requires a considerable investment so as the improvements in the conditions of professionals engaged in loading operation and unloading of goods.
Chemically treated microwave-derived biochar: An overview

Biochar, a carbon-rich material, can be produced via microwave pyrolysis, as a more energy and cost
saving method compared to conventional externally heated pyrolysis. Biochar has versatile applications,
for example, for soil amendment purpose and pollutant removal from wastewater. Chemical treatment
has been proven to improve the physical and chemical properties of biochar for better applicability. Thus,
extensive amount of research has been conducted on chemical treatment of conventional biochar, and
several review articles have discussed published works on the chemically treated conventional biochar.
However, there has been no review on works involving the chemically treated microwave-derived
biochar, by far. This paper presents an overview of the current development and improvement on
chemical treatment methods and applications of microwave-derived biochar.
Neural regulation of immunity

Survival of living organisms depends on their capacity to develop defence mechanisms against environmental challenges that cause tissue damage and infections. These protective functions involve the nervous system and the immune system, two systems traditionally considered as independent. However anatomical and cellular bases for bidirectional interactions between them have been established and a new paradigm on a regulatory role of the nervous system on immune functions is emerging. 
Pain is one of the major signs of inflammation. Upon acute injury, inflammation or infections noxious signals are perceived by nociceptors present in tissues, such as the skin. These sensory neurons convey the damaging information to the brain and release a number of mediators locally that could modulate immunity. The goal of this project is to decipher the functional role of sensory neurons and pain sensitivity on immune responses. We will tackle this highly challenging question by studying the immune responses to vaccination in genetic mouse models in which skin innervation by nociceptors is deficient. Our preliminary results are very promising as we already demonstrated that deficits in sensory skin innervation affect both the innate and adaptive immune responses to intradermal vaccine. We will further study the cellular and molecular mechanisms involved in this local and systemic modulation of the immune response by the nervous system. As a complementary approach, we will address the role of an exacerbated pain response on immunity through the selective stimulation of nociceptive neurons in wild type animals.
This interdisciplinary study is designed to provide new insights into how the nervous system instructs the immune system. Results from NEURIMMUNE are expected to open new avenues of research on the integrated host response to pathogens with important implications for the design of innovative prophylactic vaccines and therapies.
Precious Commodity: Providing Water for America’s Cities

As an essential resource, water has been the object of warfare, political wrangling, and individual and corporate abuse. It has also become an object of commodification, with multinational corporations vying for water supply contracts in many countries. In Precious Commodity,  Martin V. Melosi examines water resources in the United States and addresses whether access to water is an inalienable right of citizens, and if government is responsible for its distribution as a public good. Melosi provides historical background on the construction, administration, and adaptability of water supply and wastewater systems in urban America. He cites budgetary constraints and the deterioration of existing water infrastructures as factors leading many municipalities to seriously consider the privatization of their water supply. Melosi also views the role of government in the management of, development of, and legal jurisdiction over America s rivers and waterways for hydroelectric power, flood control, irrigation, and transportation access. Looking to the future, he compares the costs and benefits of public versus private water supply, examining the global movement toward privatization.
Translation of adaptive optical microscopy expertise to the commercial domain

Adaptive optics (AO) is an important technology for high-resolution microscopy that overcomes imaging problems when focusing inside biological specimens. Through the ERC Advanced Grant AdOMiS we have developed and experimentally validated new, broadly applicable AO tools that make integration of this technology more practical for a range of different microscopy techniques. We have also accumulated significant know-how about effective implementation of this technology. The challenge now is to translate these laboratory-based methods and know-how outside the academic research environment. This project will facilitate access to the products of our research to potential research and commercial adopters so that they can successfully deploy our AO methods in their systems.
Relearning perception action in rehabilitation from a systems perspective

Movement disorders related to perception and action, such as stroke, significantly impair functioning in daily living, severely impacting the life of affected individuals and having a huge economic impact. Although rehabilitation practice aims to restore functional ability through re-learning perception-action couplings, it leads to marginal improvements of daily functioning at best. Here it is argued that to improve effectiveness of rehabilitation a systems approach should be adopted to understand processes underlying perception-action disorders. A systems approach takes into account nonlinear interactions between components, enabling to explain for instance why patients do not respond stereotypical to rehabilitation training. REPAIRS (RE-learning Perception-Action In Rehabilitation from a Systems perspective) is a unique and timely training-through-research school, aiming to improve rehabilitation effectiveness. REPAIRS starts from systems-based fundamental knowledge on learning perception-action couplings to build applications to rehabilitation, while exploiting recent technology advancements. This research school provides the required critical mass of top-level researchers connecting European academic, clinical and technology experts to train the next generation of researchers and entrepreneurs in this perspective. REPAIRS studies interaction between four levels of the perception-action cycle: brain, muscles & joints, agent-environment and social, which is integrated with requirements on translation from clinical, technology and philosophical domains. The focus on interactions between levels and domains naturally ensures an interdisciplinary and intersectoral training. Integrating this with a high-level training of transferrable skills, dissemination and communication while exploiting an Experiential Skill Learning Workshop, will boost the employability of the young researchers involved and the innovation potential of Europe through reshaping rehabilitation.
Mechanobiology of nuclear import of transcription factors modeled within a bioengineered stem cell niche.

Many therapeutic applications of stem cells require accurate control of their differentiation. To this purpose there is a major ongoing effort in the development of advanced culture substrates to be used as “synthetic niches” for the cells, mimicking the native ones. The goal of this project is to use a synthetic niche cell culture model to test my revolutionary hypothesis that in stem cell differentiation, nuclear import of gene-regulating transcription factors is controlled by the stretch of the nuclear pore complexes. If verified, this idea could lead to a breakthrough in biomimetic approaches to engineering stem cell differentiation.
I investigate this question specifically in mesenchymal stem cells (MSC), because they are adherent and highly mechano-sensitive to architectural cues of the microenvironment. To verify my hypothesis I will use a combined experimental-computational model of mechanotransduction. I will a) scale-up an existing three-dimensional synthetic niche culture substrate, fabricated by two-photon laser polymerization,  b) characterize the effect of tridimensionality on the differentiation fate of MSC cultured in the niches, c) develop a multiphysics/multiscale computational model of nuclear import of transcription factors within differentially-spread cultured cells, and d) integrate the numerical predictions with experimentally-measured import of fluorescently-labelled transcription factors.
This project requires the synergic combination of several advanced bioengineering technologies, including micro/nano fabrication and biomimetics. The use of two-photon laser polymerization for controlling the geometry of the synthetic cell niches is very innovative and will highly impact the fields of bioengineering and biomaterial technology. A successful outcome will lead to a deeper understanding of bioengineering methods to direct stem cell fate and have therefore a significant impact in tissue repair technologies and regenerative medicine.