SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
11????-HSD1 INHIBITORS

The invention relates to compounds of formula (I) wherein A, Y, Z<SUP>1</SUP>,<SUP/>Z<SUP>2</SUP>,<SUP/>R<SUP>1 </SUP>to R<SUP>3 </SUP>and X<SUP>1 </SUP>to X<SUP>4 </SUP>have the meaning as cited in the description and the claims. For example A is 4'-fluorobiphen-4-yl; Y is -S(O)2NH-; R<SUP>1</SUP>, R<SUP>2 </SUP>are H; X<SUP>1</SUP>,<SUP/>X<SUP>2</SUP>,<SUP/>X<SUP>4 </SUP>are CH; X<SUP>3 </SUP>is C-F; Z' is =0; and Z<SUP>2</SUP>-R<SUP>3</SUP> is N(CH2CH3)<SUB>2 </SUB>. Said compounds are useful as 11ß-HSD1 inhibitors. The invention also relates to the preparation of such compounds as well as the production and use as medicament.
Internalisation of machining

The project provides for the internalisation of the machining process until today subcontracted by Tecniforja, representing an upgrade of Forja. This leap in technical terms reveals an increase in value in the chain leading in turn to maximising the degree of internationalisation of the company.
Guarantee Organizations Network

The project is aimed at providing an overview of existing experiences with credit guarantee in the East European, identifying the current policy issues of credit guarantee development in East European and recommending how the Government can address specific actions in order to create a more enabling environment. In this context, the project aims to create a pilot project, intended as a form of technical assistance to the creation of a specific guarantee system or to the implementation of an already existing guarantee scheme. This project will enable development of new opportunities of investment in the CADSES countries, thanks to innovative tools such as: new financial services, innovative activities aimed at creating new business opportunities, helping to introduce counter-guarantee instruments (by the European Investment Fund) and to promote the development of national co-guarantee instruments. GO Network actions are intended to improve enterprises access to financial and banking services and the search for innovative financial instruments to support SMEs.
Rapid assessment of ship grounding over large contact surfaces

A simple method for the rapid assessment of ship bottom structures subjected to grounding over seabed obstructions with large contact surfaces is proposed in this paper. It has been recognised that the shape and size of the seabed obstruction is of crucial importance in relation to the characteristics of bottom damage. Most studies on ship grounding are concerned with ‘rock-type’ sharp obstructions, where plate tearing is the dominating failure mode. However, very few studies are found related to grounding over blunt obstructions with large contact surfaces such as ‘shoals’. Denting rather than tearing is more likely for the bottom plating as observed from actual grounding incidents. The sharp obstruction may cause earlier penetration and result in very unfavourable consequences such as compartment flooding. In contrast, the bottom plating may not fracture when moving over a blunt-type sea floor. But it may threaten the global hull girder resistance and give rise to even worse consequences such as hull co...
In-Situ thermal rock properties lab

The ITHERLAB project investigates the influence of in-situ (present state in the geological subsurface) pressure and temperature on rock thermal properties (thermal conductivity and thermal diffusivity) as one of the essential thermal properties in the evaluation of the Earth thermal field. The ITHERLAB project will establish mathematic formulations for p/T dependence of both parameters and demonstrate whether micro-structural effects affect these relations for different rock types. For that purpose, an innovative laboratory device will be developed and pilot-tested allowing for dry and saturated rocks measurements of thermal conductivity and thermal diffusivity at pressures and temperatures that are simultaneously raised to values up to 200 MPa and 200°C, respectively. These are the conditions for depths (to approx. 7 km), which are of interest in the use of Earth resources (such as geothermal energy, hydro-carbons, storage of energy or waste). Currently, no laboratory standard procedure exists for this task. Precise knowledge of reliable in-situ thermal rock properties and derived thermal parameters (e.g. heat-flow density) is in-dispensable for understanding the Earth’s subsurface thermal structure and heat budget. Heat mainly drives geody-namic processes (e.g. mantle convection, plate tectonics). Practical implications for the society are arising for exam-ple from the extraction of the Earth’s heat for heating purposes or electricity generation and from the subsurface storage of heat to compensate different seasonal energy demands - techniques that can help to secure and diversify Europe’s energy supply. Moreover, knowledge and methods provided by the ITHERLAB project are paramount for the planning, management and realization of any scientific and industrial subsurface application, which is affected technologically or economically by the subsurface thermal field (temperature and heat budget).
The Comparative Impact of Pictorial Annotations and Morphological Instruction on Lexical Inferencing of Iranian Intermediate EFL Learners

One of the main ways to acquire unfamiliar words is to make guesses about words meaning. This study investigates the comparative effects of pictorial annotations and morphological instructions on Iranian EFL learners’ lexical inferencing ability. Considering homogeneity issues using PET (Preliminary English Test), the researchers assigned the participants into two experimental and one control groups. All groups took a vocabulary self-report test before the treatment. The treatment contained 6-weeks long reading texts tasks with 40 underlined and boldfaced target words. Groups differed as one experimental group was taught mainly through the annotated pictures technique while the other experimental group through the aid of morphological analysis of unknown words and the control group receiving the traditional root vocabulary learning technique. The results of a one-way analysis of variances (ANOVA) between the self-report vocabulary test and a piloted researcher-made lexical-inferencing post-test revealed no significant difference in performances of morphological instruction group and control group. The results also indicated that the pictorial annotation group significantly outperformed the morphological group on inferring the unfamiliar lexical items. It can be concluded that the outcomes of this study may provide insights to EFL teachers as well as students on how to best approach guessing target words while reading a text.
Clinical peptidomic analysis by a one-step direct transfer technology: Its potential utility for monitoring of pathophysiological status in female reproductive system disorders

To date, numerous studies have searched for candidate molecules or clinical examination methods as potential biomarkers for monitoring intractable diseases, such as carcinomas. Evidence accumulated over the past decade shows that many proteolytic peptides appear in human humoral fluids, including peripheral blood, in association with an individual's health condition. Although an analysis of the whole peptide (the 'peptidome') using mass spectrometry is thought to be one of the most powerful and promising experimental approaches, it has failed to identify biomarkers in the clinical blood samples, presumably due to the methodological limitations. In general, commonly used techniques for proteomic analysis of blood require the removal of large amounts of serum/plasma proteins prior to mass spectrometry analysis, and this step seems to have resulted in the overlooking of important biomarkers during the analytical process. Here, we provide a brief overview of a new quantitative peptidomic analysis by a one-step direct transfer technology without depletion of major blood proteins. Using this technology, we herein report experimental data on serum peptidomic analysis for patients with pregnancy-induced hypertension as a clinical model. In addition, we refer to the potential utility of this approach for the monitoring of pathophysiological status in female reproductive system disorders in general.
OS CONSUMIDORES COMO SUJEITOS DE DIREITOS FUNDAMENTAIS E A SUA TUTELA NO MERCOSUL

O presente artigo dedica-se a uma análise, sob a metodologia de revisão bibliográfica, sobre a efetivação do direito a dignidade humana e a proteção ao consumidor sob a ótima dos direitos fundamentais e os mecanismos de proteção do consumidor no Mercado Comum do Sul – Mercosul. Para tanto, percorre brevemente um histórico das ações tomadas pelo bloco econômico na proteção do consumidor mercosulino desde a sua criação até o projeto de Acordo do Mercosul sobre o direito aplicável aos contratos de consumo, com o objetivo de se analisar a construção das medidas protetivas estabelecidas pelos comitês especializados na matéria do Direito do Consumidor para verificar-se que mesmo que haja uma vontade de se legislar e padronizar o tratamento dos consumidores nos países integrantes do bloco, conclui-se que ainda é necessário um maior aprofundamento da questão, que depende de vontade política, econômica e diplomática.
Sustainable development of river tourism on the Upper Tagliamento

“RAPIDE” is based on a concept devised by the municipality of Forni di Sopra which, through the sustainable and environment-friendly use of the Upper Tagliamento for river tourism - kayaking, rafting, canyoning, etc. - intends to direct the tourist flows towards its territory and to the other municipalities involved. Therefore, the high naturalistic value of the area, which at present is not widely known at a national level, is going to be enhanced, thus contributing to raising the visitors’ environmental awareness. Apart from the coordination, the financial-economic management and the cooperation with Italian and Slovenian partners, the project will build infrastructures along the river, so as to ensure the fruition of an eight-kilometre stretch. Specifically, three docking facilities will be set up while expanding the existing parking space, with the addition of light infrastructures (changing rooms, toilets, benches and tables) and the positioning of signage and other useful information. There follows the organisation of launching and promotional events, according to a targeted marketing strategy. In this sense on the occasion of said events tourists will have the chance to practice water activities for free. The last stage of the initiative includes the monitoring, assessment and dissemination of results, also in order to transfer the acquired experience to areas with similar features. This will hopefully have favourable economic effects on the tourist ancillary sector (restaurants, reception services, shops), with a consequent improvement of the employment rates and a decrease in the depopulation of the mountain areas.
Cobermaster Concept 2020 - 2022

The project aims to strengthen the positioning of international markets through the promotion of its premium furniture products for hotel, office and home, based on the revolutionary 3D grade, development and design 100 % national.
Higher Education Demands of the Labor Market

Abstract Over recent decades the youth unemployment rate remains at a high level.These factors determine the research of the graduates demand in different areas of the labor market. For the detailed analysis the following training areas were selected: economics, human resources management, information technologies, philology. We have conducted studies using content analysis of employers’ offers in these areas, interviewing senior students to identify their preferences with regard to the future place of work, and the analysis of wide range of graduates in the Tatarstan Republic in 2013. Research has shown that the most demanded are graduators of the areas of personnel management and economy, and most well paid are the specialists in the field of information technologies and personnel management.
MicroRNAs: regulators of cancer metastasis and epithelial-mesenchymal transition (EMT)

Tumor metastasis is the main cause of death in patients with solid tumors. The epithelial-mesenchymal transition (EMT) process, in which epithelial cells are converted into mesenchymal cells, is frequently activated during cancer invasion and metastasis. MicroRNAs (miRNAs) are small, non-coding RNAs that provide widespread expressional control by repressing mRNA translation and inducing mRNA degradation. The fundamental roles of miRNAs in tumor growth and metastasis have been increasingly well recognized. A growing number of miRNAs are reported to regulate tumor invasion/metastasis through EMT-related and/or non-EMT- related mechanisms. In this review, we discuss the functional role and molecular mechanism of miRNAs in regulating cancer metastasis and EMT.
Flow Boiling Heat Transfer Enhancement from Carbon Nanotube-Enhanced Surfaces

This paper presents an experimental study of flow boiling heat transfer from carbon nanotube (CNT) structures in a two-phase cooling facility. Multi-walled CNT (MWCNT) structures of dimensions 80 mm × 60 mm were applied to a horizontal flow boiling channel. Two CNT structures with different properties viz. NC-3100 and MERCSD were tested with a dielectric liquid FC-72. The height of the CNT structures was fixed at 37.5 μm and tests were conducted at coolant mass fluxes of 35, 50, and 65 kg/m 2 ·s under saturated flow boiling conditions. The experimental results show that the CNT structures enhance the boiling heat transfer coefficients by up to 1.6 times compared to the smooth aluminum surface. The results also show that the CNT structures increase significantly the Critical Heat Flux (CHF) of the smooth aluminum surface from 66.7 W/cm 2 to 100 W/cm 2 .
Method for adjusting sensor during manufacture of motor car, involves comparing object positions determined relative to vehicle reference axis, to produce comparative data and adjusting preset sensor as a function of comparative data

The method involves positioning (50) a sensor detectable object within a detection area and determining (60,70) a position of the object relative to reference axis of a vehicle by different sensors. The predetermined orientation of the specific sensor is relative to the reference axis of the vehicle. The positions of the object determined by the sensors are compared (80) so as to produce a comparative data. The preset sensor is adjusted (90) as a function of the comparative data. Independent claims are included for the following: (1) device for adjustment of sensor of vehicle; (2) computer program product for adjustment of sensor of vehicle; and (3) machine readable medium storing program for adjustment of sensor of vehicle.
Semiconducting ZnO effect on Maxwell–Wagner relaxation in HfO<sub>2</sub>/ZnO nanolaminates fabricated by atomic layer deposition

Amorphous nanolaminates (NLs) consisting of alternate HfO2 and ZnO oxide sublayers were prepared using an atomic layer deposition method. Cross-sectional transmission electron microscopy observations reveal the existence of high-quality interfaces in the NLs. Dielectric properties are shown to depend more strongly on the ZnO sublayer thickness with respect to the number of interfaces. With increasing the ZnO thickness in the (1.7 nm) HfO2/ZnO NLs, the enhanced permittivity is clearly observed despite the same or an even lower number of interfaces, and the large permittivity persists up to 105–106 Hz, followed by a step-like decrease at the higher frequency. Frequency dependence of dielectric loss is combined with a complex impedance analysis to understand the physical origin underlying the enhancement of permittivity and the effect of the ZnO sublayer thickness. It suggests that the enhancement be attributed to the presence of numerous charge carriers in the ZnO semiconducting sublayer, which results in a large accumulation of the charges at the HfO2/ZnO interfaces through Maxwell–Wagner relaxation. The present work proves an effective way for improving dielectric properties by increasing the electrical conductivity of one of the sublayers in laminating systems.
European procurers platform - ehealth  - transforming the market for ehealth solutions

Public Procurement of Innovation (PPI) is a crucial challenge for public bodies to be implemented during next years. The “usual” way of purchasing goods is based solely on the price of the product. Life cycle costing, supply chain analysis or group purchase are rarely used, which means missing some opportunities to get innovative products that would give purchasers competitive advantage. Therefore, there is an urgent need to start developing networks of procurers. Such networks will enable them to identify common needs, conduct market analysis, understand supply chain, use these tools to comprise a higher procurement volume, and achieve bigger impact on suppliers. It will allow them voice out their unmet needs, create a new demand to access sustainable products of higher quality, and develop new applications with lower life cycle costs. This can be obtained through PPI.

Information and Communication Technologies (ICT) has equally become an essential tool used in nearly all areas of society. Health sector, which is the core of this proposal, is no exception to this regard. The target of the project is to understand health care public procurers unmet needs, particularly in eHealth. That is why a network of procurers will be developed within the scope of the project. The network will allow the consortium to identify common needs, explore the best available solutions and stimulate the market with the aim of creating a PPI/PCP procurement strategy for the eHealth sector. In order for the EPP-eHealth consortium to be able to achieve the mentioned objectives, a set of 4 workshops aimed at project members and potential stakeholders will be developed. Three of these workshops will train attendees in public procurement while a 4th workshop will be used as a market test. 

Finally and aiming to widespread project results, a comprehensive set of dissemination activities will be carried out.
The first portable, low-cost, robotized scanner microscope that converts any smartphone into a high quality and intelligent tele-microscopy image diagnosis system

Healthcare accounts for approximately 10% of global gross domestic product. While the average life expectancy increases and some diseases are disappearing, other diseases raise. Cost of healthcare is a major economical challenge leading to unequal distribution of health benefits, which starts with the access to medical diagnosis. This situation and the new 
industrial revolution creates an opportunity to transform and innovate in the healthcare domain. 

MicroSpot is the first portable, low-cost, robotized scanner microscope that converts any smartphone into a high quality and intelligent microscopic image diagnostic system. MicroSpot is connected to a cloud ecosystem, capable of real time streaming and remote control and an artificial intelligence assistant for image analysis.

MicroSpot aims to replace the actual obsolete equipment and processes used in microscopic medical image diagnosis while revolutionizing current manufacturing methods. MicroSpot democratizes the access to clinical image diagnosis by creating a new generation of medical devices that reduces time, costs and distances bringing microscopic image diagnostics closer to the point of care.
Creative entrepreneurship in ceramic regions – developing, educating, encouraging

Ceramics are deeply rooted in our daily lives (tableware, tiles, architectures etc.) and quality products rely on creative designers that understand the material and its functionalities. CE aggregates an EU wide unique set of regions with long-standing traditions and up-to-date knowledge in this field. The wider sector offers jobs for 0,5 M employees, of whom 80% in SMEs. However, the regions remain scattered and far from exploiting their economic potential. Furthermore, global competition (e.g. low-budget products from China) is significantly threatening the sector.
CerCee establishes a CE-wide CCI-network which pulls together key-knowledge institutes, SME, regions and a network of museums, the latter acting as hub for co-operative development, memory function, accessible archive and marketing platform. The projects aim is to counteract the global pressure through 1) merging regional approaches first-time towards a joint CE-knowledge pool by assessing and mapping existing knowledge, approaches and economic potential of SME, by 2) Developing cooperative and EU-wide applicable trainings and education & outreach activities for boosting entrepreneurial skills and knowledge base to regional creative SME and by 3) co-developing and piloting innovative marketing strategies and cooperative e-commerce portai. All activities are strongly supported and facilitated by up-to-date IT-tools to boost accessibility, skill development and marketing. A key-output is the virtual and overall accessible “City of Ceramics”, a knowledge, marketing and cooperation hub for the CE-ceramic CCI.
CerDees innovative approach is twofold: 1) the tools and marketing strategies will be new to this sector; 2) the joint, transnational approach and the CE-wide web-Portal is a first-timer to this sector. The transnational added value will be the widely accessible knowledge base, the cooperative and synergetic development of applicable approaches and a long-term cooperation hub/platform.
LIGHT WEIGHT MOLDED ROOF TILE WITH INTEGRATED SOLAR CAPABILITIES

An improved building roof tile for a sloping roof including a polyurethane foam tile that includes outer coating layers that are made of a uniquely fire resistant or retardant layered system that includes a first outer fire resistant layer of 100% solid aliphatic polyurea material and a second inner layer of an 100% solid intumescent non-halogenated phosphate material, said inner layer forming a fire blocking partition and said outer layer offering UV protection, featherweight, category 5 hurricane proof, yields a high R-value, offer low thermal transference into attic space, will retrofit any sloped roof without structural build-up, can be molded into single or triple units, cannot break under foot or when extreme pressures are applied, can produce upgradable solar energy, is easy to transport and install and can molded to look like slate, wood, flat roll tile or most other historical tiles.
Research Design in European Studies: Establishing Causality in Europeanization

Europeanization: The Challenge of Establishing Causality C.M.Radaelli Looking for Causality in the Literature on Europeanization T.Exadaktylos & C.M.Radaelli Causality in Quantitative Approaches A.E.Toller Europeanization: A Critical Realist Perspective I.Bache , S.Bulmer & D.Gunay Discursive Institutional Analytical Strategies K.Lynggaard Beyond Non-compliance with Legal Norms S.Saurugger Delayed Europeanization: Multiple Hypotheses and Small Number of Cases D.Panke The Europeanization of Healthcare: Processes and Factors D.S.Martinsen How Cities Encounter Europe: Mechanisms and Modes S.Dossi Understanding Causality and Change in Party Politics R.Ladrech Europeanization of Foreign Policy outside the Common Foreign and Security Policy T.Exadaktylos Rival Hypotheses: Comparing the Roles of the EU and Black Sea Economic Cooperation Organization in Good Governance Reforms S.Ladi Being Clear Enough to be Wrong: Europeanization Refuted and Defended K.Moumoutzis Lessons Learned: Beyond Causality C.M.Radaelli & T.Exadaktylos