SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Characterization of a Fatty Acyl-CoA Reductase from <i>Marinobacter aquaeolei</i> VT8: A Bacterial Enzyme Catalyzing the Reduction of Fatty Acyl-CoA to Fatty Alcohol

Fatty alcohols are of interest as a renewable feedstock to replace petroleum compounds used as fuels, in cosmetics, and in pharmaceuticals. One biological approach to the production of fatty alcohols involves the sequential action of two bacterial enzymes: (i) reduction of a fatty acyl-CoA to the corresponding fatty aldehyde catalyzed by a fatty acyl-CoA reductase, followed by (ii) reduction of the fatty aldehyde to the corresponding fatty alcohol catalyzed by a fatty aldehyde reductase. Here, we identify, purify, and characterize a novel bacterial enzyme from Marinobacter aquaeolei VT8 that catalyzes the reduction of fatty acyl-CoA by four electrons to the corresponding fatty alcohol, eliminating the need for a separate fatty aldehyde reductase. The enzyme is shown to reduce fatty acyl-CoAs ranging from C8:0 to C20:4 to the corresponding fatty alcohols, with the highest rate found for palmitoyl-CoA (C16:0). The dependence of the rate of reduction of palmitoyl-CoA on substrate concentration was cooperative, with an apparent K(m) ~ 4 μM, V(max) ~ 200 nmol NADP(+) min(-1) (mg protein)(-1), and n ~ 3. The enzyme also reduced a range of fatty aldehydes with decanal having the highest activity. The substrate cis-11-hexadecenal was reduced in a cooperative manner with an apparent K(m) of ~50 μM, V(max) of ~8 μmol NADP(+) min(-1) (mg protein)(-1), and n ~ 2.
Multimodal prevention of pain, nausea and vomiting after breast cancer surgery.

Despite many one- or two-modal attempts to relieve postoperative nausea and vomiting (PONV) and pain, postoperative issues following breast cancer surgery remain a substantial problem. Therefore, the aim of this explorative, hypothesis-generating study was to evaluate the effect of a multimodal, opiate-sparing, evidence-based regimen for prevention of PONV and pain.Two hundred consecutive patients scheduled for breast cancer surgery were included. The prevention regimen included a package consisting of preoperative paracetamol, dextromethorphan, celecoxib, gabapentin, dexamethasone, total intravenous anaesthesia and intraoperative ondansetron. The patients were prospectively scored according to PONV, pain during rest and mobilization and major side effects.Of 200 consecutive breast cancer patients, 191 received the full package. During the first 36 postoperative hours, 79.1% reported no PONV at all and only 3.7% reported severe PONV. At rest, 69.6% reported no or light pain and 3.1% reported severe pain, with corresponding values of 59.7% and 8.9% during arm mobilization. Mean postoperative morphine consumption was 2.2 mg. The only significant side effect was transient dizziness.A multimodal, opiate-sparing regimen to prevent pain and PONV seems to be more effective than one- or two-component regimens on PONV and pain after breast cancer surgery, a result which calls for large-scale multi-center or randomized studies.
Development of an interactive Lombardy-Ticino statistical system for monitoring migration flows and commuting across borders

In spite of regulatory, technical and cultural asymmetries, the border areas (Lombardy - Ticino) maintain intense and continuous relationships. In order to understand and manage these phenomena it is necessary to have dedicated statistical information (homogeneous data focused on dynamic interaction processes between the areas. On this front the project intends to remedy by creating a statistical monitoring platform that collects, harmonizes and disseminates homogeneous statistical data on the concerned areas, and valid original indicators for the measurement of the phenomena. Decision makers, academia, citizens) and the thematic focus will be placed on the processes of commuting and migration in their various forms.
Feasibility study for the cbt academy

- Several market trends have resulted in a decreasing availability of workers fit for and/or interested in positions which require medium-to-high skills in the ICT sector (as code programming). All the while, ICT companies grow exponentially and increasingly other sectors need programming for their daily activities (Big Data). This has caused a “Skills Gap”, which by 2020 will result in the shortage of 85 million medium-to-high skilled workers and a surplus of 90+ million low skilled workers.
- The identification of this market failure, which has tremendous impact on the performance and growth of companies (lost revenue and higher costs) throughout the EU, motivated CBT to develop an innovative business model to commercially explore this opportunity with the “CBT Academy” project.
- Its’ business model and concept are based on organizing training courses to up-skill capable low-skilled workers into medium-to-high skills code programmers. The courses’ content will be defined by the effective needs of CBT Group’s ICT clients thus increasing the employment potential of the Academy’s trainees. This concept can be summarized as “Just-in-Time Skills”, where potential candidates enter a course knowing that a job opportunity will be waiting for them if they finish it successfully.
- More than 15 years of experience in the recruitment sector, in various countries, have validated the need and willingness-to-pay of companies for the results the CBT Academy wants to achieve (regular groups of motivated, capable and mobile workers to fill the growing positions with programming tasks). Although the concept is considered promising, the company feels the need to further explore, detail and quantify the business model. For this, it will develop a Feasibility Study focusing on defining and studying critical variables of the business, the deliverable to the Phase 1 of the SME Instrument.
- Thus, this proposal inserts itself in the INSO-10-2015-1 call: “SME Business model innovation”.
Duemmler, Kerstin; Nagel, Alexander-Kenneth: Governing Religious Diversity: Top-down and bottom-up initiatives in Germany and Switzerland

In recent years religious pluralization has become a significant policy issue in Western societies as a result of a new awareness of religion and of religious minorities articulating themselves and becoming more visible. The article explores the variety of social and political reactions to religious diversity in urban areas and in doing so it brings together theoretical concepts of political and cultural sociology. The notion of diversity governance as joint endeavour of state and societal actors managing societies is linked to the notion of boundary work as interplay of state and/or societal actors maintaining or modifying boundaries between religious traditions. Based on two case studies the article illustrates two idealtypical settings of diversity governance: The first case from the German Ruhr Area stands for a bottom-up approach which is based on civic self-organization of interreligious activities whereas the second case from the Swiss canton of Lucerne exhibits a model of top-down governance based on state interventions in religious instruction at schools. Drawing on semi-structured interviews and participant observation the authors show how different governance settings shape the construction and blurring of boundaries in the religious field. Both approaches operate differently when incorporating religious diversity and rendering former homogenous notions of we-groups more heterogeneous. Despite of the approaches initial aim of inclusion, patterns of exclusion are equally reproduced since the idea of ‘legitimate religion’ rooted in Christian majority culture is present.
Spectrophotometric complexation of cephalosporins with palladium (II) chloride in aqueous and non-aqueous solvents

The complexation reaction of cephalosporins namely cefotaxime (CTX), cefuroxime (CRX), and cefazolin (CEFAZ) with palladium (II) ions have been studied in water and DMF in 25 °C by the spectrophotometric methods. The method is based on the formation of yellow to yellowish brown complex between palladium (II) chloride and the investigated cephalosporins in the presence of sodium lauryl sulfate (SLS) as surfactant. The complexation process was optimized in terms of pH, temperature and contact time. The stoichiometry of all the complexes was found to be 2:1 (metal ion/ligand) for CTX, CRX, and 1:2 for CEFAZ. The stoichiometry of palladium (II)-cephalosporins was estimated by mole ratio and continuous variation methods and emphasized by the KINFIT program. These drugs could be determined by measuring the absorbance of each complex at its specific λmax. The results obtained are in good agreement with those obtained using the official methods. The proposed method was successfully applied for the determination of these compounds in their dosage forms.
Click chemistry for future gene therapies to benefit citizens, researchers and industry

Gene therapy is expected to play a key role in next-generation medicine by correcting the underlying genetic causes of disease, thereby facilitating personalised medicine. Current gene therapy methods possess undesirable side effects, including insertional mutagenesis, toxicity, low efficiency and off-target cutting. Questions also remain regarding the optimal methods for delivering nucleases into cells and tissues. These limitations will be addressed through the original and innovative approach of the ClickGene network. 

ClickGene’s research objectives are to train 14 ESRs in the field of biomaterials development with specific focus on, i.) site-selective genetic engineering, ii.) liposomal nanoparticle drug delivery, and iii.) optogenetic diagnostic probes for epigenetic base detection. Most of our academic partners are key members of COST Action CM1201: Biomimetic Radical Chemistry and all have outstanding international reputations as scientific leaders in their field. This COST Action will play a vital role in both networking and training elements of ClickGene, and in combination with transferable skills training, intersectorial and cross-disciplinary secondment, and industry targeted workshops, the education of biomaterials chemists with expertise in click-chemistry and cutting edge application areas of gene therapy, nanotechnology and biological diagnostics will be achieved. 

The training provided will match the skills required by next-generation research leaders in biopharmaceutical, nanotechnology, biodiagnostic and other industries. Allied to academic strength in this network, ClickGene features highlycompetitive industry partners with expertise in commercialisation of nucleic acid click-chemistry (baseclick, ATDBio) and liposomal and lipidome technology (LipiNutraGen). Thus, synergy between both commercial and academic partners will enable ESRs to develop gene-targeted technology within a highly productive, engaging, and exciting training network.
Challenging the standard model with the scrutiny of b to qll transitions

Today, Particle Physics is in an unusual situation with a theory, the Standard Model (SM), able to accurately describe a very large number of precise measurements but at the cost of ad hoc features in the fermionic sector. Furthermore, the SM is unable to answer key questions raised by cosmological observations. Consequently, the ball is now on experiment side to search for signs of non-SM physics (NP). The most straightforward way to hunt for NP particles is to seek for their signatures directly in the data, but none of them has been found today. Therefore, this project focuses on indirect searches which rely on the quantum nature of particles. Since b-hadrons study is an ideal field for this type of searches, I propose to explore the Flavour-Changing Neutral Currents b-> sll  and b-> dll transitions to draw the identity card of the NP particles which may be at play. Due to experimental constraints, our current knowledge is limited: the published results are mostly related to the b-> s mumu transitions and the observations of b-> see are rare. With the Chiaroscuro project, I will be able to study for the first time the angular properties of the decay products of the b-> s ee transitions over the full kinematical domain for a variety of b-hadrons to investigate the NP couplings to the electron (e) and muon (mu) particles. Another important question is the coupling of NP with the quarks of the first and second families: are the b->sll and b->dll transitions impacted the same way by NP? In order to answer this interrogation, I will study Lb and Bc hadrons decays - uniquely accessible at the LHC - using cutting edge reconstruction techniques.
The project will use the LHCb detector running at the LHC to benefit from the huge b-hadron production rate. In order to cope with the increasingly challenging data-taking conditions, the project will develop innovative techniques in the electron reconstruction and precise calibration of the LHCb electromagnetic calorimeter.
Implementation of DSP System for Discrete Transforms using VHDL

Cosine transform (DCT), Inverse DCT, Discrete Fourier Transform (DFT) and Fast Fourier Transform (FFT) are performed by DSP system on one platform. This paper represent the design of a Digital Signal Processor (DSP) system described using VHDL and implement in a Field Programmable Logic Array (FPGA). The Fast Fourier Transform (FFT) is one of the rudimentary operations in field of digital signal and image processing. Some of the very vital applications of the fast Fourier transform include Signal analysis, Sound filtering, Data compression, Partial differential equations, Multiplication of large integers, Image filtering etc. Fast Fourier transform (FFT) is an efficient implementation of the Discrete Fourier Transform (DFT). This paper concentrates on the development of the Fast Fourier Transform (FFT), based on Decimation-In-Time (DIT) domain, Radix-2 algorithm, this paper uses VHDL as a design entity, and their Synthesis by Xilinx Synthesis Tool. The input of Fast Fourier transform has been given by testbench and output has been displayed using the waveforms on the Xilinx Design Suite 13.1.The synthesis results show that the computations for calculating the Fast Fourier transform. By using a fixed geometry addressing, pipeline designing and block fixed point structure, the data has the greater precision and dynamic range. The results show that the design is efficient, strongly extensive and occupies less resource. It is a good method to meet the high-speed digital signal processing requirements.
Biofilm-Resistant materials for hard tissue implant applications

Implant-associated infections, commonly caused by biofilm-forming bacteria, are highly problematic for the patient, the healthcare system, and society. BIOREMIA will recruit 15 doctoral students (ESRs) and provide a highly inter-disciplinary joint research & training programme focused on the key issues that determine the future antibacterial biomaterials and technologies for orthopaedic and dental applications. BIOREMIA links 7 academic and 4 non-academic beneficiaries as well as 6 partners from 11 European countries (Germany, Austria, Greece, Sweden, UK, Spain, Italy, France, Switzerland, Ireland and the Netherlands) and the USA. The ESRs will be supervised and trained by world-class academic and industrial organisations, combining technical knowledge with hands-on training in state-of-the-art research projects. BIOREMIA training program will include face-to-face and online scientific courses in biomaterials & surface engineering, biotechnology,nanotechnology, implant manufacturing, biochemistry, microbiology and biofilm. This will be complemented by education in transferable skills such as entrepreneurship, management, IPR, communication etc. useful for getting an innovation-oriented mind-set of young researchers. Participating in BIOREMIA will make PhD students highly attractive for employers and open up doors for their successful careers in research, regulation, consulting, industry and the healthcare system. They will be experts for the better assessment of the antibacterial functionality of materials and surfaces and for delivering successful strategies for the medical device industry and the healthcare system. The strong involvement of the industrial sector will provide the ESRs with a holistic perspective on career opportunities. Beyond the trained researchers, this network will produce innovative materials and technologies that will enhance the productivity of European industry and improve the well-being of European citizens by minimizing implant-associated infection rates.
Continual acoustic based multifunctional cage mounted fish estimator deigned to reduce feed waste, fish mortality, and predator and fish escape control

The growing demand for sea food has resulted in the depletion of natural fisheries and it is estimated that 62% of the sea food will come from aquaculture farms by 2030. The profitable operation of aquaculture farms is being hindered by unbalanced and un-predictive fish feed amount, unreliable biomass estimation, fish escape and fish mortality. Fish feed alone represents 50% of the total operating costs of the fish pans and cages. Permanent and accurate estimation of fish size and weight is of significant importance in the fish farming industry for the provision of key data with which feeding, grading and harvesting operations are controlled.
Ocean Tools Aquaculture (OTAQ) is an industry leader in providing predator control and acoustic technologies for the aquaculture industry. Our solution is to develop an acoustic based permanent in-cage biomass estimator system (FISHSTIMATOR) that will deal with the problems being faced by aquatic fish farmers. The solution is intended to reduce fish feed waste by 3-5% by giving recommended amount of feed that matches the number of fish and their growth rate. Fish mortality and escape due to predators, anomalies in the cage structure and thieves will be eliminated by close monitoring of the cage environment. FISHSTIMATOR will be sold to farmers at €26’000 per cage and leased for €13’000 per cage. With this pricing model we envisage to clinch to 16% of the global aquaculture monitoring market which is estimated to reach €5.24 billion at a compound annual growth rate of 5.24% by 2020 (3% of €175billion - global aquaculture market) and increase our revenue from €2.5M to €84M by 2022.
In Phase 1 we will validate FISHSTIMATOR prototype, develop Intellectual Property strategy, and carry out a market study, search and recruit partner and draft a business plan in a period of 6 months.
In Phase 2, we will finalise the design and operability of FISHSTIMATOR allowing us to match the requirements of the targeted customers. The prototype dev
Exploration and Practice of PBL + LBL Double-track Mode in the Teaching of Dermatology and Venerology

To investigate the effect of PBL and LBL double-track mode in the teaching of dermatology and venereology.70 medical students in 5-year program from grade 2007 in our medical school were randomly selected and divided into two groups:trial group practiced PBL and LBL double-track mode teaching,while control group practiced LBL teaching.The results of exam showed that the students in trial group had a significant higher score in sum score,analysis subjects and basic skills score than those in control group.The students of trial group were more active in learning,more capable of independent thinking and expressing themselves.The quality of education has been improved through PBL combined with LBL teaching methods.The double-track teaching mode has been widely accepted by students.
Beating HF waves to generate VLF waves in the ionosphere

[1] Beat-wave generation of very low frequency (VLF) waves by two HF heaters in the ionosphere is formulated theoretically and demonstrated experimentally. The heater-induced differential thermal pressure force and ponderomotive force, which dominate separately in the D and F regions of the ionosphere, drive an electron current for the VLF emission. A comparison, applying appropriate ionospheric parameters shows that the ponderomotive force dominates in beat-wave generation of VLF waves. Three experiments, one in the nighttime in the absence of D and E layers and two in the daytime in the presence of D and E layers, were performed. X mode HF heaters of slightly different frequencies were transmitted at CW full power. VLF waves at 10 frequencies ranging from 3.5 to 21.5 kHz were generated. The frequency dependencies of the daytime and nighttime radiation intensities are quite similar, but the nighttime radiation is much stronger than the daytime one at the same radiation frequency. The intensity ratio is as large as 9 dB at 11.5 kHz. An experiment directly comparing VLF waves generated by the beat-wave approach and by the amplitude modulation (AM) approach was also conducted. The results rule out the likely contribution of the AM mechanism acting on the electrojet and indicate that beat-wave in the VLF range prefers to be generated in the F region of the ionosphere through the ponderomotive nonlinearity, consistent with the theory. In the nighttime experiment, the ionosphere was underdense to the HF heaters, suggesting a likely setting for effective beat-wave generation of VLF waves by the HF heaters.
CR singular images of generic submanifolds under holomorphic maps

The purpose of this paper is to organize some results on the local geometry of CR singular real-analytic manifolds that are images of CR manifolds via a CR map that is a diffeomorphism onto its image. We find a necessary (sufficient in dimension 2) condition for the diffeomorphism to extend to a finite holomorphic map. The multiplicity of this map is a biholomorphic invariant that is precisely the Moser invariant of the image when it is a Bishop surface with vanishing Bishop invariant. In higher dimensions, we study Levi-flat CR singular images and we prove that the set of CR singular points must be large, and in the case of codimension 2, necessarily Levi-flat or complex. We also show that there exist real-analytic CR functions on such images that satisfy the tangential CR conditions at the singular points, yet fail to extend to holomorphic functions in a neighborhood. We provide many examples to illustrate the phenomena that arise.
Structural member and/or coupling arrangement and/or method for same

A structural has a coupling region. The coupling region is a region where a fitting and a beam section of the structural member meet and over such region a nipping sleeve of the structural member is over-molded.
Doctoral discourses in South Africa

In the South African context, three doctoral discourses are heard, each with their own assumptions about the purpose of doctoral education and the kinds of people who undertake doctoral study, and with their own implications for the practice of doctoral education. Two of the three discourses are familiar and well documented in the local and international literature. The third is an emerging discourse identified in the course of a qualitative study of four doctoral programmes at three South African universities. This paper unpacks these discourses, examining tensions that arise between them. I argue that all three discourses contribute useful perspectives to our national understanding of doctoral education, and I discuss some implications for the practice and research of doctoral education.