SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Triple negative breast cancer control through synergistic inhibition of egfr and cdk9 signaling

Triple negative breast cancer (TNBC) is an aggressive disease, accounting for 15-20% of breast cancer cases, but disproportionally causing breast cancer-related death. TNBC does not express the targetable receptors ER, PR, and HER2 that are known to drive other forms of breast cancer. Mainstay practice for TNBC in the clinic is to treat with non-targeted cytotoxic chemotherapies. Long-term outcomes are however still poor, most likely owing to intrinsic drug resistance. Clinical trials have attempted to explore molecular targeted therapies to block dysregulated growth factor receptors in TNBC, for instance, epidermal growth factor receptor (EGFR), as it is overexpressed in ~80% of TNBC. Yet, giving the long-standing availability of clinically approved EGFR-targeted therapies, such as lapatinib, the clinical benefit of single agent therapy is unsatisfactory, owing to the compensatory dysregulated signaling pathways. In our ongoing ERC – Advanced Grant Triple-BC (#322737) we are striving to explore combinatorial molecular targeted therapies to concomitantly block the identified dysregulated signaling pathways. Our preliminary work revealed that an inhibitor targeting cyclin-dependent kinase 9 (CDK9) strikingly synergized with targeting EGFR receptor family signaling to inhibit cell proliferation of TNBC cell lines. The overall goal of this PoC project is to exploit this novel finding and provide proof-of-concept evidence that stalling CDK9 signaling may enable successful targeted combination therapy in TNBC. Therefore, the specific objective is to assess the pharmacological response of dual EGFR-CDK9 targeting in TNBC patient-derived xenograft (PDX) mouse models in vivo. We envisage that this PoC project will translate our identified successful synergistic treatment into an effective future novel and safe combinatorial targeting strategy benefiting TNBC patients.
I Just Want My Research Credit: Frequency of Suboptimal Effort in a Non-Clinical Healthy Undergraduate Sample

Although performance validity testing is becoming fairly routine in clinical settings, research protocols involving neuropsychological tests infrequently include assessments of performance validity. The current study utilized an embedded measure of effort over two administrations of CNS Vital Signs to determine the frequency of poor effort in non-clinical healthy undergraduate students participating in a research study for course credit. Results indicate that more than 1 in 10 college students participating in a cognitive test battery for research showed test scores consistent with inadequate effort, which was associated with poor performance on testing across many domains. This conclusion was supported by poor performance on many other subtests. Healthy college students with suboptimal effort (n = 11) had an overall score in the 15th percentile on average compared to the 48th percentile in the rest of the students (n = 66). Those who failed validity indicators on the baseline administration were more likely to fail validity indicators on the repeat administration. Those who were tested in the morning were also more likely to fail validity indicators. The current study provides evidence for the potential limitations of conducting research using neuropsychological tests with healthy college student volunteers in the absence of performance validity testing. Revised college-level cutoffs are proposed.
Information theoretic evaluation of random content generation in games

INTERCOGAM’s goal is to develop and use information theory based intrinsic motivation formalisms to evaluate automatically generated game mechanics. Content generation is one of the production bottlenecks of professional game design, which has begun to be addressed by procedural content generation. In this field, search based procedural content generation uses the idea of evolutionary algorithms to represent, modify and adapt games and game content to maximize fun and engagement with the game. One major challenge here is the identification of widely applicable fitness functions, which capture the different aspects of what makes a game fun, such as challenge level, complexity, pacing, etc. INTERCOGAM will relate psychological and game design concepts of game experience to either existing formalisms for intrinsic motivation or develop new ones, where appropriate. Human play testers will then play procedurally generated games and evaluate their own experience, allowing us to verify whether our formalism captures the actual human motivation, and whether humans indeed act according to certain intrinsic motivations. INTERCOGAM will yield both, a tool to generate new and engaging game ideas, aiding better and faster game design, and provide new insights into how the human mind engages with different worlds where there is no external reward present.
Inhomogeneous chiral condensate in the quark-meson model

The two-flavor quark-meson model is used as a low-energy effective model for QCD to study inhomogeneous chiral condensates at finite %temperature $T$ baryon chemical potential $\mu_B$. The parameters of the model are determined by matching the meson and quark masses, and the pion decay constant to their physical values using the on-shell and modified minimal subtraction schemes. Using a chiral-density wave ansatz for the inhomogeneity, we calculate the effective potential in the mean-field approximation and the result is completely analytic. The size of the inhomogeneous phase depends sensitively on the pion mass and whether one includes the vacuum fluctuations or not. Finally, we briefly discuss the mean-field phase diagram.
Influence of Ionic Complexation on Release Rate Profiles from Multiple Water-in-Oil-in-Water (W/O/W) Emulsions

Water-in-oil-in-water (W/O/W) double emulsions were prepared, and the kinetics of release of magnesium ions from the internal to the external water phase was followed. Different chelating agents (phosvitin and gluconate) were used to bind magnesium within the prospect of improving the ion retention in the internal aqueous droplets. Magnesium release was monitored for 1 month of storage, for each formulation, with and without chelation, at two storage temperatures (4 and 25 degrees C). Leakage occurred without film rupturing (coalescence) and was mainly due to entropically driven diffusion/permeation phenomena. The experimental results revealed a clear correlation between the effectiveness of chelating agents to delay the delivery and their binding capacity characterized by the equilibrium affinity constant. The kinetic data (percent released versus time curves) were interpreted within the framework of a kinetic model based on diffusion and taking into account magnesium chelation.
High-Performance Stable Field Emission with Ultralow Turn on Voltage from rGO Conformal Coated TiO2 Nanotubes 3D Arrays

A facile method to produce conformal coated reduced graphene oxide (rGO) on vertically aligned titanium oxide (TiO2) nanotubes three dimensional (3D) arrays (NTAs) is demonstrated for enhanced field emission display applications. These engineered nano arrays exhibit efficient electron field emission properties such as high field emission current density (80 mA/cm(2)), low turn-on field (1.0 V/μm) and field enhancement factor (6000) with high emission current stability. Moreover, these enhancements observed in nano arrays attribute to the contribution of low work function with non-rectifying barriers, which allow an easy injection of electrons from the conduction band of TiO2 into the Fermi level of reduced graphene oxide under external electric field. The obtained results are extremely advantageous for its potential application in field emission devices.
Enabling decentralized real-time analysis of smart distribution systems using wireless communication

Wireless communications, distributed intelligence and automated control systems are the key technological components in achieving the goals of the smart grid, e.g. self-healing, optimum operation, and power quality. In this paper, we are proposing a novel approach that utilizes wireless communications to enable decentralized real-time analysis of distribution systems. Each bus (node) in the distribution system has a processing unit that communicates with other relevant nodes in the system. Each processing unit performs a part of the overall analysis, and forwards the results to relevant nodes. The proposed framework has been implemented using GNU-Octave, and the Network Simulator NS-3. GNU-Octave was used to verify the validity, accuracy and speed of the framework. A WiMAX network was used as the communication layer, and NS-3 simulations captured the WiMAX network performance, e.g. average packet delay, average packet delivery ratio, and average convergence times for different number of nodes.
Problem solving stages in the five square problem

According to the restructuring hypothesis, insight problem solving typically progresses through consecutive stages of search, impasse, insight, and search again for someone, who solves the task. The order of these stages was determined through self-reports of problem solvers and has never been verified behaviorally. We asked whether individual analysis of problem solving attempts of participants revealed the same order of problem solving stages as defined by the theory and whether their subjective feelings corresponded to the problem solving stages they were in. Our participants tried to solve the Five-Square problem in an online task, while we recorded the time and trajectory of their stick movements. After the task they were asked about their feelings related to insight and some of them also had the possibility of reporting impasse while working on the task. We found that the majority of participants did not follow the classic four-stage model of insight, but had more complex sequences of problem solving stages, with search and impasse recurring several times. This means that the classic four-stage model is not sufficient to describe variability on the individual level. We revised the classic model and we provide a new model that can generate all sequences found. Solvers reported insight more often than non-solvers and non-solvers reported impasse more often than solvers, as expected; but participants did not report impasse more often during behaviorally defined impasse stages than during other stages. This shows that impasse reports might be unreliable indicators of impasse. Our study highlights the importance of individual analysis of problem solving behavior to verify insight theory.
Simple models of carbon and nitrogen cycling in New Zealand hill country pastures: exploring impacts of intensification on soil C and N pools

Concerns about climate change and water quality make it necessary to have a better understanding of the cycling of carbon (C) and nitrogen (N) within landscapes. In New Zealand, pastoral farming on hill country is a major land use, and there is little information available at a landscape level on the cycling of C and N within these systems, particularly the impacts of land use intensification. Published information on the individual components of C and N cycles in hill country pastoral systems was used to construct simple C and N models for two notional hill country paddocks with contrasting amounts of annual net herbage accumulation (NHA). These simple models of C and N cycling were used to explore the potential impacts of intensification on soil C and N pools. The C and N models constructed illustrate that both the C and N cycles in hill country pastoral farming are characterised by large fluxes in and out of the system and relatively small annual accumulations or depletions of their respective soil poo...
A DEVICE, METHOD AND SYSTEM OF WIRELESS COMMUNICATION OVER AN EXTREMELY RADIO-FREQUENCY BAND

Disclosed is a method, circuit and system for wireless communication, including communication in an extremely high radio frequency range. There is provided a transmitter, such as an orthogonal frequency-division multiplexing ("OFDM") based transmitter, which may transmit data in a frequency band residing within the range of 5 GHZ to 300GHZ using transmission symbols.
Commercialisation of advanced extrusion technologies delivering disruptive innovation for the next generation of catheter based medical devices.

ExtruLub is an innovative, disruptive extrusion technology applicable across a range of medical polymer resins, which has the ability to change the surface of a catheter without affecting core device properties. The technology sits in the component sub-supply global market with an initial value of €564mn applicable across all catheter markets (combined value of $42.5bn globally by 2020). From a functional perspective, ExtruLub has the ability to reduce surface friction, generate protective antimicrobial & anti-thrombogenic surfaces & deliver site specific drugs all whilst reducing catheter profile. This enhancement of catheter function assists in safeguarding patient safety & will command genuine product differentiation for the original equipment manufacturer (OEM) of the end device, enabling them to gain market share.From an economic perspective it facilitates a change from lean to batch manufacturing realising cost containment for the target customer.Taking the cardiology sector as an example, an independent study demonstrated ExtruLub would reduce costs for the OEM (eg Boston Scientific, Medtronic etc.) by 51% realising savings of ca. €3mn p.a in one product. In the urology sector, the measured impact showed increased gross margins of ca.13% on one product line alone enabling €21.5 mn p.a. savings for potential customers like Hollister, Coloplast etc. DiaNia Technologies ambition is to grow into a world leading, international technology company, realising market share through disruptive technologies.Our initial goal is to replace current ExtruLub alternatives attaining a 30% market share with the friction product, equating to €170mn in full production.Harnessing advanced polymer chemistry through materials science and engineering has the potential to realise €23.3mn in revenue & 15 new, highly skilled jobs within the first 4 years through a business model preferred by OEMs.This disruptive technology is the key to advancing the next generation of medical devices.
3-Dimensional Object Perception for Manipulation Tasks Using the Atlas Robot

The goal of the DARPA Robotics Challenge (DRC) is the development of ground robots capable of executing complex tasks in disaster relief environments. The Virtual Robotics Challenge (VRC) was the first phase of the competition, in which teams develop their own software to maneuver a simulated robot through a virtual obstacle course and perform a set of complex tasks. In these scenarios, grasping and manipulation tasks are required; therefore this paper provides a description of the visual 3-Dimensional (3D) perception functionality to grasp a hose lying on a table, one of the tasks of the challenge. The sensor head of the used Atlas robot is equipped with a laser range scanner and a stereo camera, which provide the 3D point cloud to be processed. The presented approach processes the point cloud; a plane detector is used to segment the scene and a tabletop assumption is then considered to detect the objects of interest. The hose connector is recognized using color-based region growing segmentation and then its pose is estimated by a cylinder model fitting. The experimental results demonstrate the efficiency of the proposed 3D perception pipeline in the scenario under study.KeywordsPoint CloudHumanoid RobotStereo CameraManipulation TaskSensor HeadThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
Hans Urs von Balthasar and Adrienne von Speyr's Ecclesial Relationship

Many systematic theologians acknowledge the relationship between Hans Urs von Balthasar, the significant twentieth-century Catholic theologian, and Adrienne von Speyr, the Swiss physician and Catholic mystic. There is, however, difficulty understanding the actual character and purpose of this relationship. I argue in this paper that Paul's theology of charism, particularly dealing with double mission charisms, will help us understand correctly the ecclesial relationship between von Balthasar and von Speyr. After an overview of von Balthasar's statements regarding the relationship and the three main interpretations of it, I offer my own interpretation of this relationship by using Paul's theology of charism. The ramifications will be a reinterpretation of central aspects of von Balthasar's theology including but not limited to his theology of Holy Saturday, Trinitarian theology, and theology of the communion of saints.
The Geopolitics of Natural Resources

This significant collection examines the diverse ways natural resources are managed and controlled and the controversies that arise regarding their use, allocation, and protection resulting from governance decisions and policies. Professor Feldman has selected seminal works which focus on several key issues, including the role of common property resources in questions of trans-boundary resource management, the diverse ways societies and interest groups accord value to resources and their use, and how resources are catalysts for both international conflict and cooperation. This authoritative volume will be of immense value to students, professionals and practitioners interested in the field of geopolitics and natural resources.
Safety in nanomaterials & nanotechnology

The potential of nanomaterials and nanotechnology to improve the quality of life, to address society’s grand challenges and to contribute to economic growth and to sharpen the competitiveness of industry is now widely recognized, not only in Europe, but globally. Nanomaterials and nanotechnology offer substantial possibilities for improving the competitive position of the EU and for responding to key societal challenges. However, there is a need to ensure the safe development and application of nanomaterial and nanotechnologies and for finding reliable ways to predict the potential risks to health, food and environment of these materials and technologies . Due to the widespread use of nanomaterials, it is critical to identify any potential risks they may pose to human health or the environment. These current uncertainties surrounding nanomaterial risk mean that research is required into nanomaterial safety. Addressing these knowledge gaps will help to ensure that innovation in the rapidly developing area of Nanotechnology is not stifled by concern, but instead by determining risks associated with nanomaterials we can promote the safe, sustainable and responsible use of this technology.
SiNfONiA aims at attracting and maintaining a high profile researcher (ERA Chair) and respective research team with excellent research capabilities in the nanosafety research domain. SiNfONiA will play as a catalyst to fully maximise the impact of the ERA Chair on the scientific excellence and research performance of the International Iberian Nanotechnology Laboratory (INL).
Capitalisation of the green energy projects in the MED area

The transnational challenge of the project is the cohesion and blending of the results arising from modular projects by creating a common network among all the established partnership resulting in a community in which activities and results will be shared. This objective will be achieved by creating links among different consortia that could share results of activity afferent the same fields of competence, thus widening the targets achieved by individual projects through the complementarity of skills and the sharing of the results. The main outputs of the project will be the creation of a MED community and of synergies among the projects, the analysis and management of the community project results, the dissemination and capitalization of the outcomes. The approach of the project foresees a common and easy to use communication supports realisation, the participation to thematic events and the enlargement of existing thematic networks dedicated to renewable energy in islands and rural areas. These activities will also involve actors other than the modular projects partners in order to create the conditions and links allowing to exploit and use the different projects results at larger scale. The expected change will be the boosting of the impact that each project can achieve thanks to the immediate multiplication of the targets reached and the growth of the expertise gained by comparing the results obtained with different approaches.
Magnetic Shielding With YBCO Coated Conductors: Influence of the Geometry on Its Performances

A superconducting magnetic shield can be built as a stack of several sections of milled 2G coated conductors. Each section consists of a closed loop where persistent currents can flow and provide a strong attenuation of external dc magnetic fields. The purpose of the present work is to study experimentally several geometries of such magnetic shields made out of YBa2Cu3O7 (YBCO) coated conductors from SuperPower. Our aim is to investigate in detail the influence of the aspect ratio and the number of layers of the assembly on the magnetic shielding properties. In order to do so, the magnetic shield is subjected to an axial quasi-static (“dc”) magnetic field ramped slowly at a fixed sweep rate. A Hall probe is used to measure the local magnetic induction inside the assembly as a function of the applied magnetic induction. Results show that the shielding factor, SF, (defined as the ratio between the applied magnetic induction and the magnetic induction measured inside the shield) is improved for increasing aspect ratios of the global coated conductor assembly and that the threshold magnetic induction (defined for SF = 10) increases with the number of layers. Using a double layer of 18 sections at T = 77 K, dc magnetic fields up to 56 mT can be shielded by a factor larger than 10. Finally, the effect of an air gap of constant width between coated conductor sections is also characterized.
Research, connections, networks and culture - use of projects, games, research and digital in education

The project proposal under the title ReConNeCt Restart 3 (REsearch, CONnections, NEtworks and CulTure - Use of Projects, Games, Research And Digital in Education) extends on the previous experience gained in the ReConNeCt project that ran in 2019 and 2020, and after having major changes caused by global pandemic, the main idea of bringing together researchers and the public at large of all ages, will be done in mixed environment live experience with researchers and digital (Virtual and Augmented Reality) enhanced events. As the brink of a new decade always signifies changes and modernization, and since the digital science industry in Serbia is currently blooming, we want to a make the digital science the main theme of the EU Researchers Night in 2021.  Placing the digital in focus of our program reflects the trends and interests of the new generations that will create and sustain the future (Gen Y and the coming Gen Z). Naturally, the digital and the virtual overcome the physical and spatial barriers and hence magnify the impact on the young audience whose lives and interactions are nowadays dominantly conducted on a digital plane.