SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Choosing your weapons: On sentiment analysis tools for software engineering research

Recent years have seen an increasing attention to social aspects of software engineering, including studies of emotions and sentiments experienced and expressed by the software developers. Most of these studies reuse existing sentiment analysis tools such as SentiStrength and NLTK. However, these tools have been trained on product reviews and movie reviews and, therefore, their results might not be applicable in the software engineering domain. In this paper we study whether the sentiment analysis tools agree with the sentiment recognized by human evaluators (as reported in an earlier study) as well as with each other. Furthermore, we evaluate the impact of the choice of a sentiment analysis tool on software engineering studies by conducting a simple study of differences in issue resolution times for positive, negative and neutral texts. We repeat the study for seven datasets (issue trackers and Stack Overflow questions) and different sentiment analysis tools and observe that the disagreement between the tools can lead to contradictory conclusions.
Panitumumab Use in Metastatic Colorectal Cancer and Patterns of KRAS Testing: Results from a Europe-Wide Physician Survey and Medical Records Review

From 2008-2013, the European indication for panitumumab required that patients' tumor KRAS exon 2 mutation status was known prior to starting treatment. To evaluate physician awareness of panitumumab prescribing information and how physicians prescribe panitumumab in patients with metastatic colorectal cancer (mCRC), two European multi-country, cross-sectional, observational studies were initiated in 2012: a physician survey and a medical records review. The first two out of three planned rounds for each study are reported.The primary objective in the physician survey was to estimate the prevalence of KRAS testing, and in the medical records review, it was to evaluate the effect of test results on patterns of panitumumab use. The medical records review study also included a pathologists' survey.In the physician survey, nearly all oncologists (299/301) were aware of the correct panitumumab indication and the need to test patients' tumor KRAS status before treatment with panitumumab. Nearly all oncologists (283/301) had in the past 6 months of clinical practice administered panitumumab correctly to mCRC patients with wild-type KRAS status. In the medical records review, 97.5% of participating oncologists (77/79) conducted a KRAS test for all of their patients prior to prescribing panitumumab. Four patients (1.3%) did not have tumor KRAS mutation status tested prior to starting panitumumab treatment. Approximately one-quarter of patients (85/306) were treated with panitumumab and concurrent oxaliplatin-containing chemotherapy; of these, 83/85 had confirmed wild-type KRAS status prior to starting panitumumab treatment. All 56 referred laboratories that participated used a Conformité Européenne-marked or otherwise validated KRAS detection method, and nearly all (55/56) participated in a quality assurance scheme.There was a high level of knowledge amongst oncologists around panitumumab prescribing information and the need to test and confirm patients' tumors as being wild-type KRAS prior to treatment with panitumumab, with or without concurrent oxaliplatin-containing therapy.
SELEÇÃO DE CLONES DE EUCALYPTUS PARA REGIÃO NORTE DE MATO GROSSO

O Eucalipto é uma das espécies mais importantes e a base da silvicultura florestal no Brasil.Porém, no estado de Mato Grosso ainda existem poucos estudos voltados a avaliar o desempenho destes plantios, ou selecionar híbridos e clones que possuam
REDUCED HANDOVER FAILURE FOR SINGLE RADIO VOICE CALL CONTINUITY

A user equipment (UE) reduces handover failure when the UE is prematurely handed over to a target cell during a single radio-voice call continuity (SRVCC) procedure or when the target cell is unavailable. In one instance, the UE prevents handover of a packet-switched (PS) voice call from a serving cell of a PS radio access technology (RAT) to the target cell of a circuit-switched (CS) RAT after the UE sends a measurement report for the target cell but before receiving a handover command. The UE prevents the handover if the target cell becomes undesirable for handover and/or the serving cell becomes desirable for maintaining the PS voice call.
ESTABLISHING A COMMUNICATION SESSION

A secure communication session is established between a first endpoint (50) and a second endpoint (42). The first endpoint (50) can contact the second endpoint (42) via a first communication network (20) and via a second communication network (30). The first communication network (20) is more trusted than the second communication network (30). The first endpoint (50) determines that a secure communication session is required. A security association is established between the endpoints for the communication session on a connection (11) via the first communication network (20). Service is received on a connection (12) via the second communication network (30) using the previously established security association. The step of establishing a security association can comprise authenticating the second endpoint and negotiating a shared secret and the step of receiving service on a connection (12) via the second communication network (30) can occur without any further negotiation of key material or authentication between the endpoints via the second communication network (30).
Transporte aéreo em Santa Catarina: aviação regional e dinâmicas territoriais

Cette recherche cherche à faire une discussion sur le transport aérien de passagers dans l'état de Santa Catarina. Elle vise ainsi à comprendre l'importance de l'infrastructure aéroportuaire dans le développement régional et urbain, en considérant les impacts causés par la fluidité et la compétitivité dans l'organisation territoriale dans le contexte de Santa Catarina. Dans l'ouvrage, la genèse de l'aviation commerciale, le réseau urbain et le remodelage des stratégies logistiques de l'État et du secteur des entreprises sont mis en évidence comme éléments intégrant les dynamiques territoriales liées au secteur aérien et vice-versa. En résumé, il s'agit de démontrer que la concentration des services aériens sur le territoire analysé reflète le processus de formation socio-spatiale, la division territoriale du travail et les stratégies adoptées par les agents impliqués. This research seeks to make a discussion about air passenger transportation in the state of Santa Catarina. With this, it aims to understand the importance of airport infrastructure in regional and urban development, considering the impacts caused by fluidity and competitiveness in territorial organization in the context of Santa Catarina. In the work, the genesis of commercial aviation, the urban network and the remodeling of logistical strategies of the State and the corporate sector are highlighted as elements that integrate the territorial dynamics linked to the airline sector and vice-versa. In summary, it is intended to demonstrate that the concentration of air services in the territory under analysis reflects the process of socio-spatial formation, the territorial division of labor and the strategies adopted by the agents involved.
Morphology is not Destiny: Discrepancy between Form, Function and Dietary Adaptation in Bovid Cheek Teeth

Mammal teeth have evolved morphologies that allow for the efficient mechanical processing of different foods, therefore increasing dietary energy uptake for maintenance of high metabolic demands. However, individuals masticate foods with biomechanical properties at odds with the optimal function of a given tooth morphology. Here, we investigate tooth form and function using two quantitative 3D methods at different scales on the same individuals of nine bovid species. Dental topometry quantifies the gross morphology, and therefore, reflects evolutionary adaptive patterns. Surface texture analysis infers mechanical occlusal events, which reflect the actual tooth function, and is free from the influence of morphology. We found that tough foods can be satisfactorily exploited by grazing species with enamel ridge morphologies not more complex than those found in intermediate feeders and browsers. Thus, the evolution of enamel complexity is likely determined by a balance between adaptation and constraints. Wider enamel ridges seem to be a common functional trait in bovids to compensate for severe wear from abrasive foods and/or chipping from hard foods. Our results demonstrate that supposedly essential functional adaptations in tooth morphology may not be required to process food efficiently. This emphasizes the large plasticity between “optimal” morphology and the potential function of the tooth, and underscores the need to appreciate (apparently) maladaptive structures in mammalian evolution as nevertheless effective functioning units.
Intra erythrocyte  dexamethasone  in  the  treatment  of  ataxia telangiectasia

The main objective of the project is to provide a treatment of the neurological symptoms of patients with Ataxia Telangiectasia (AT), a rare progressively disabling and life-shortening genetic disease for which no therapy is currently available. To achieve this, a pivotal Phase III study will be conducted, to allow regulatory filing to obtain market authorization in EU and USA by 2019. EryDex is an innovative product, developed by EryDel, used to administer dexamethasone sodium phosphate by ex-vivo encapsulation in autologous erythrocytes, which are infused into the patient. EryDex provides long-term delivery of low doses of dexamethasone without the typical steroid side effects and has reached a successful Phase II trial conducted in AT patients. The phase III trial will be an international, multi-center, 1 year, randomized, prospective, double-blind, placebo-controlled, designed to assess the effect of 2 dose ranges of EryDex, administered monthly by IV infusion, on neurological symptoms of AT patients. The protocol of the trial and the regulatory path to registration has already been agreed upon with EMA and FDA.
An international patient registry will also be set with the aim of establishing and maintaining a comprehensive clinical database of patients with AT and closely related conditions, enabling the monitoring of AT epidemiology, the development of an evidence-based natural history of the condition, identification of biomarkers as well as development of clinical guidelines.
The AT NEST, the first scale to assess symptoms specific to AT patients, coordinated by the AT centre at the John’s Hopkins University, will be tested in the study and if validated will represent the 1st scale assessing chief areas of impairment specific to AT. 
In parallel to the clinical trial, investigations into the molecular mechanisms of action of EryDex will be performed with the objective to provide the validation of a new biomarker predictive of treatment efficacy.
Age-Selective segregation of organelles

Our tissues are constantly renewed by stem cells. Over time, stem cells accumulate cellular damage that will compromise renewal and results in aging. As stem cells can divide asymmetrically, segregation of harmful factors to the differentiating daughter cell could be one possible mechanism for slowing damage accumulation in the stem cell. However, current evidence for such mechanisms comes mainly from analogous findings in yeast, and studies have concentrated only on few types of cellular damage.
I hypothesize that the chronological age of a subcellular component is a proxy for all the damage it has sustained. In order to secure regeneration, mammalian stem cells may therefore specifically sort old cellular material asymmetrically. To study this, I have developed a novel strategy and tools to address the age-selective segregation of any protein in stem cell division. Using this approach, I have already discovered that stem-like cells of the human mammary epithelium indeed apportion chronologically old mitochondria asymmetrically in cell division, and enrich old mitochondria to the differentiating daughter cell. We will investigate the mechanisms underlying this novel phenomenon, and its relevance for mammalian aging.
We will first identify how old and young mitochondria differ, and how stem cells recognize them to facilitate the asymmetric segregation. Next, we will analyze the extent of asymmetric age-selective segregation by targeting several other subcellular compartments in a stem cell division. Finally, we will determine whether the discovered age-selective segregation is a general property of stem cell in vivo, and it's functional relevance for maintenance of stem cells and tissue regeneration. Our discoveries may open new possibilities to target aging associated functional decline by induction of asymmetric age-selective organelle segregation.
GENERACION DE PLANTAS CON ALTERACIONES EN EL CONTENIDO DE ACEITE PROTEINAS O FIBRAS

Plantas que presentan un fenotipo de mayor cantidad de aceite o un fenotipo de mejor calidad de harina debido a la expresion modificada de un ácido nucleico HIO. También se describen métodos de generacion de plantas con un fenotipo de mayor cantidad de aceite o fenotipo de mejor calidad de harina.
Statin use and incident erectile dysfunction — A nationwide propensity-matched cohort study in Taiwan

Statins are commonly prescribed for cardiovascular diseases which have been reported to share many contributory underlying mechanisms with erectile dysfunction (ED). However, the correlation between statin use and incident ED is uncertain.We conducted a population-based propensity-matched cohort study by identifying new statin users among male patients 40-79 years of age in the period 2000 to 2010. A statin nonuser control cohort matched for age, propensity score, and index year at a 3:1 ratio was selected for comparison. Cohorts were tracked for the occurrence of any type of incident ED according to the registry of ED diagnosis in the database. The association between statin use and the risk of ED was evaluated by Cox proportional hazard model and adjusted by age, PS, socioeconomic status, comorbidities, and medications.Compared with nonusers, statin users had a significantly lower risk of incident ED (HR, 0.75; 95% CI, 0.63-0.90, p=0.002). Further analysis demonstrated that statin users in the group of middle-aged (40-49 years old) or high-potency statin treated (i.e., rosuvastatin, atorvastatin, and simvastatin) had lower HR for incident ED. Analysis in the patterns of cumulative statin exposure also showed that high-potency statins could decrease the HR for incident ED in dose- and duration-dependent manners.Statin use was associated with a reduced risk of incident ED in the middle-aged men in Taiwan. The potency and the cumulative exposure of statin utilized played critical roles.
Motion planning software for autonomous car industry

More than 90% of road accidents are attributed to driver errors. Thus, there is an urgent need to transform conventional driving towards autonomous driving and make car traffic safer. One of the major challenges in the autonomous car industry, besides sensing, localization and mapping is safe planning of the vehicle motion. Motion planning algorithms are responsible for defining a path to follow, avoiding obstacles and generating the best trajectory that ensures safety, comfort and efficiency. This is a hot topic for the development community, which is still awaiting reliable and robust solutions to solve complex situations, without the need to create pre-programmed solutions for each scenario. To this aim, embotech, introduces the EMP (Embotech Motion Planner), a cutting-edge motion planning software for autonomous vehicles. Using a deterministic approach and physics-based models, the proposed solution generates high-dimensional motion trajectories to assist various self-driving tasks such as valet parking, highway driving and urban driving. The EMP enables fully flexible motion planning, capable to safely perform complex manoeuvres in real time with standard automotive ECUs. Characterized by seamless integration, EMP is one core solution easily adaptable to any new car model. Embotech is a spin-off from the Automatic Control Laboratory from ETH Zurich; our team includes experts in embedded optimizations technologies. We are part of several automotive industry-led incubation programs benefitting from expert coaching and mentoring. Our plan is to reach the market through direct sales to OEMs and Tier 1 suppliers. With a volume-based royalty business model, we expect to reach a SME Instrument Phase 2 project ROI of 8.68 by 2025.
Jacob Böhme, <i>Ein gründlicher Bericht von dem irdischen Mysterio und dann von dem himmlischen Mysterio (1620)</i>. Hg. von <i>Günther Bonheim</i> unter Mitarbeit von <i>Michael Spang</i>. (Historisch-kritische Gesamtausgabe I 5) frommann-holzboog, Stuttgart-Bad Cannstatt 2020. LXIX/88 S., € 58,–.

Article Jacob Böhme, Ein gründlicher Bericht von dem irdischen Mysterio und dann von dem himmlischen Mysterio (1620). Hg. von Günther Bonheim unter Mitarbeit von Michael Spang. (Historisch-kritische Gesamtausgabe I 5) frommann-holzboog, Stuttgart-Bad Cannstatt 2020. LXIX/88 S., € 58,–. was published on December 1, 2022 in the journal Arbitrium (volume 40, issue 3).
Colaboração brasileira com autores da Austrália, Canadá, Estados Unidos e Reino Unido e o desempenho das Universidades no Ranking ARWUGRAS

Objetivo: identificar as disciplinas e universidades brasileiras que se beneficiam da colaboração científica com Austrália, Canadá, Estados Unidos e Reino Unido, visualizado a partir do desempenho no Global Ranking of Academic Subjects (ARWUGRAS). Método: estudo exploratório que identificou os artigos brasileiros indexados no InCites entre 2010-2019, e recalculou pesos para artigos em colaboração com os quatro países de língua inglesa. Os dados do InCites foram cotejados com o desempenho das universidades brasileiras presentes nas 54 disciplinas do ARWUGRAS edição 2021. Resultados: o Brasil figura em 39 das 54 disciplinas do ARWUGRAS, com a presença de 49 diferentes universidades brasileiras. Ao se retirar a colaboração internacional com países de língua inglesa, observou-se alteração no posicionamento das universidades brasileiras na lista de classificação. Os testes estatísticos demonstram vantagem significativa para a colaboração com estes países, considerando todas as disciplinas juntas. Quando testadas de forma específica por grandes áreas, observou-se que não há ganho significativo para Engenharias e Ciências da Vida, mas há resultados significativos para a vantagem apresentada pelas Ciências Naturais e Ciências da Saúde. Conclusão: a análise do desempenho das universidades brasileiras no ARWUGRAS demonstrou que há vantagem no posicionamento destas quando existe colaboração com autores provenientes da Austrália, Canadá, Estados Unidos e Reino Unido.
Platform for the frontline of osteoporosis prevention

Osteoporosis is the most common reason for broken bones among elderly women. In the European Union, annual direct medical costs of fractures attributed to osteoporosis reach €36bn and are expected to rise to €76.9bn by 2050 in pace with the aging of population.
Early diagnosis and prevention is the key to reducing this burden and deliver more efficient health care to European citizens with new tools for doctors to better serve their patients. 
Our mission at BONE VITAE (www.bonevitae.pl, Wroclaw, Poland) is to implement fast in-practice medical screening for early flags of osteoporosis with our patented osteoscanner ICT platform, the new frontline of prevention. Our non-invasive and painless bio-impedance spectroscopy technology is the only one that provides data on bone composition and chemical changes that mark the very start of osteoporosis onset, when there is still time to prevent it.
The Multi-electrode Osteoporosis Detection Device (MOsteoDD) platform is an exciting market opportunity for our company, a small, highly innovative venture with a powerful patented core technology seeking to enter the growth market of osteoporosis diagnostics worth $6–7 billion a year globally. Our patented six-electrode setup provides 95+% diagnostic accuracy results in less than 40 seconds, while the platform’s web service will analyse the device output and generate a written report for doctor’s use allowing pre-diagnosed patients to be referred for further scanning (DEXA) or for prescriptions to be issued. 
The first version of the MOsteoDD osteoscanner has clinical validation in Poland and the CE mark (Conformité Européenne), and is currently at Minimum Viable Product (MVP) stage at Technology Readiness Level (TRL) 8. Current efforts are directed at maturing the platform to specific customer needs to reach the market with the support of SMEI funding.
Size-dependent error of the density functional theory ionization potential in vacuum and solution

Density functional theory is often the method of choice for modeling the energetics of large molecules and including explicit solvation effects. It is preferable to use a method that treats systems of different sizes and with different amounts of explicit solvent on equal footing. However, recent work suggests that approximate density functional theory has a size-dependent error in the computation of the ionization potential. We here investigate the lack of size-intensivity of the ionization potential computed with approximate density functionals in vacuum and solution. We show that local and semi-local approximations to exchange do not yield a constant ionization potential for an increasing number of identical isolated molecules in vacuum. Instead, as the number of molecules increases, the total energy required to ionize the system decreases. Rather surprisingly, we find that this is still the case in solution, whether using a polarizable continuum model or with explicit solvent that breaks the degeneracy of each solute, and we find that explicit solvent in the calculation can exacerbate the size-dependent delocalization error. We demonstrate that increasing the amount of exact exchange changes the character of the polarization of the solvent molecules; for small amounts of exact exchange the solvent molecules contribute a fraction of their electron density to the ionized electron, but for larger amounts of exact exchange they properly polarize in response to the cationic solute. In vacuum and explicit solvent, the ionization potential can be made size-intensive by optimally tuning a long-range corrected hybrid functional.
ENSEÑAR A ARGUMENTAR EN CONTEXTOS RURALES A TRAVÉS DE SECUENCIAS DIDÁCTICAS: EXPERIMENTACIÓN DEL DISPOSITIVO DIDÁCTICO EN ESPAÑOL

Investigaciones previas muestran las repercusiones de la enseñanza temprana de la argumentación en, al menos, dos ámbitos: formación de ciudadanía y éxito académico. No obstante, el derecho a la enseñanza temprana de capacidades de lectura y escritura críticas se convierte en una desventaja para poblaciones que habitan en contextos rurales. El objetivo del artículo es mostrar el efecto de una secuencia didáctica basada en un género textual argumentativo en las producciones textuales de alumnos de telesecundaria. Como herramienta metodológica retomamos la secuencia didáctica basada en el género textual. Ésta ha sido utilizada en diferentes partes del mundo para la enseñanza de las lenguas. En lo que respecta al español, en México, se ha explorado su efectividad con géneros textuales que implican argumentar. Este trabajo muestra que los alumnos mejoraron la organización global y la cohesión textual en las producciones finales, así como el conocimiento del tema de discusión.