SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Targeting of host proteins by unrelated pathogen effectors and their surveillance by allelic immune receptors

Pathogens secrete effectors into host cells to promote virulence and often establish disease by interception of basal defence components. One widespread mechanism of disease resistance in plants requires nucleotide-binding oligomerization (NOD)-like receptor (NLR) genes. Recognition of an effector by a cognate NLR prevents pathogen proliferation. A co-evolutionary arms race between the host barley and the pathogenic powdery mildew fungus Blumeria graminis forma specialis hordei
(Bgh) has driven the functional diversification of allelic NLR variants encoded at the MLA disease resistance locus (for Mildew locus A). Recent work revealed that Bgh effectors detected by allelic MLA receptor variants are unexpectedly sequence-unrelated and evolved independently from different ancestors. Additionally, the MLA orthologs in wheat and rye, Sr33 and Sr50, confer isolate-specific resistance to the stem rust pathogen Puccinia graminis forma specialis tritici (Pgt). This is remarkable because rust and mildew fungi belong to different phyla and cannot encode sequence-related effectors. MLA variants can therefore not have diversified to directly bind sequence-related effectors and thus monitor effector-mediated modifications of host targets conserved between different cereals. 
To reintegrate into the European scientific community, I wish to perform the “TOPPER” project at the Max-Planck Institute for Plant Breeding Research, Cologne, Germany.
The “TOPPER” project will clarify whether the sequence-unrelated Bgh effectors target the same host protein or converge on a common signalling pathway/complex consisting of related or unrelated host proteins. I hypothesize that the host protein(s), manipulated by Bgh effectors, is/are also targeted by effectors of other plant-associated microorganisms, which will be tested here. The collaboration with the partner ‘2Blades’ will ensure direct deployment of results in agriculture to battle plant disease, where appropriate.
Performant alternative to nickel-based alloys for turbine of helicopter engine replacement

The work presented in this proposal will help the topic leader to evaluate the ability of an innovating TiAl material to replace nickel-based super-alloys for low-pressure turbine application. The PANTHER project will focus on the investigation of the resistance of TiAl alloy under high strain rate, high temperature and different stress triaxiality levels. A combined approach between numerical simulations and original experiments will help creating a reliable transient dynamics material model for behaviour and failure. An upstream methodology will be applied, aiming at testing the material from a microscopic scale to a structure scale. The work will begin by numerical simulation of a blade-off in order to evaluate the important parameters to take into consideration in the model. The results of this preliminary study will drive the experimental conditions for the material testing on Split Hopkinson Bar apparatus. A first couple of parameters will be fitted thanks to this first test campaign. The study will go on with simplified impact testing (two impact configuration) with highly instrumented targets. These tests will reveal the behaviour and failure mode of the TiAl under dynamic conditions. Numerical simulations of these experiments will be performed and material model parameters will be adjusted to correlate simulation results to experimental ones. The goal of the last testing campaign (three impact configurations) is to reproduce the real events that can occur during the life operation of an engine turbine. A last batch of numerical simulation will allow to confirm the ability of the established material model to accurately predict such complex events. The call is in THIOT’s core business and strategy. With the PANTHER project, THIOT is submitting an innovating proposal that will maintain the European industry at the cutting edge of the turbine design.
Is China a Trade Competitor of ASEAN? A Chinese Perspective on the Proposing, Cultivation and Implications of the CAFTA

China`s proposal of the CAFTA (China-ASEAN Free Trade Area) in 2001 prompted a great debate about whether China was a trade competitor of ASEAN, given their similarity in economic development levels and trade/export structures. That Beijing shifted its focus on economic cooperation from the international level to the regional level led to its proposal of the CAFTA. As the Framework Agreement (Framework Agreement on Comprehensive Economic Cooperation between China and ASEAN) showed, Beijing`s careful consideration for four newer ASEAN members (Cambodia, Laos, Myanmar and Vietnam) intended not only to help all ASEAN members develop economically, but also to narrow the economic gap existing between them and the six old ASEAN members; in return, China was recognized as a full market economy, which it is not currently recognized within the framework of the WTO. The substantial rise in bilateral trade and the structural changes of the trade in goods between China and ASEAN member nations after 2001 proves that ASEAN benefited more from the CAFTA, particularly when the areas where ASEAN had the comparative advantages were designated as the priority cooperation areas between China and ASEAN. In sum, similarities existing in economic development levels and industrial structures between China and ASEAN made them natural economic competitors. However, closer studies of trade in goods of S1-7, S1-6 and S1-0 reveal that China acted as an increasingly complementary trade partner of ASEAN after 2001.
Políticas de saúde do trabalhador no Brasil: contradições históricas e possibilidades de desenvolvimento

The Workers' Health (WH) approach understands that it is necessary to expand the object of public policies to transform the work processes that determine the health-disease relationship. This broadening brings challenges that drive the development of the formulation and implementation of policies for the surveillance and prevention of diseases. This article aimed to analyze the development of Brazilian policies on WH from the perspective of historical contradictions. To this end, the analytical concept of contradiction from Cultural-Historical Activity Theory was used. This is a scoping review, including 64 theoretical and empirical studies and gray literature published between 1991 and 2019. The results of the analysis showed that: from the change of the object of prevention inserted by the WH approach, five new contradictions emerged that are related to the predominance of instruments of the previous activity model, normative and training instruments, division of labor for assistance and surveillance actions, intra and intersectoral articulations. and social control. These contradictions have driven some changes, but some limitations persist around a challenging object.A abordagem de Saúde do Trabalhador entende que é necessário ampliar o objeto das políticas públicas para transformar os processos de trabalho que determinam a relação saúde-doença. Essa ampliação traz desafios que impulsionam o desenvolvimento da formulação e implementação das políticas para a vigilância e prevenção de agravos. O objetivo deste artigo é analisar o desenvolvimento das políticas brasileiras em saúde do trabalhador a partir das contradições históricas. Para este fim, foi usado o conceito analítico de contradição da teoria da atividade histórico-cultural. Trata-se de uma revisão de escopo que inclui 64 estudos teóricos, empíricos e literatura cinza publicados entre 1991 e 2019. Os resultados da análise mostraram que: a partir da mudança de objeto da prevenção inserida pela abordagem da Saúde do Trabalhador, emergiram cinco novas contradições que estão relacionadas ao predomínio de instrumentos do modelo de atividade anterior, instrumentos normativos e de formação, divisão do trabalho para as ações de assistência e vigilância, articulações intra e intersetoriais e controle social. Essas contradições permitiram impulsionar algumas mudanças, mas também existem limitações que persistem em torno de um objeto desafiante.
EV-VEGF NUCLEIC ACIDS AND POLYPEPTIDES AND METHODS OF USE

The present invention is directed to novel polypeptides designated herein as EG-VEGF and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Also provided herein are methods of screening for modulators of EG-VEGF. Furthermore, methods and related methods of treatment are described herein which pertain to regulating cellular proliferation and chemotaxis.
The impact of China’s economic restructuring on Southeast Asia: An investment perspective

China’s economic growth in 2015 has fallen to 6.9% from an unrivalled average of 10% between 2002 and 2014. While the global economy is feeling the impact of China’s economic restructuring, a change of such a magnitude in China has created a great impact on Southeast Asia, which is intensively involved in trade and investment with China. By analyzing macroeconomic data, we find no indication that China’s outward investment in Southeast Asia was immediately shocked by China’s New Normal. Instead, in an economically challenging era after 2007, Chinese OFDI in ASEAN has increased significantly. Though Chinese OFDI in Southeast Asia is distributed unevenly in geographical and industrial terms, the analysis of regional and sectorial distribution has reflected a paradigm shift of China’s economy from an export oriented to an investment driven growth. The rising wave of Chinese investment in ASEAN can be understood by China’s dilemma of over-capacity in some manufacturing sectors. Given the increasing production cost which has significantly reduced cost advantages of Chinese manufacturing, the rapid growth of Chinese outward investment is not only a result of a single firm’s strategic shift to relocate to seek higher returns. It is rather a collective reaction of Chinese firms to the challenging business environment in China’s domestic market.
The european medical isotope programme: production of high purity isotopes by mass separation

PRISMAP - The European medical isotope programme: Production of high purity isotopes by mass separation proposes to federate a consortium of the key European intense neutron sources, isotope mass separation facilities and high-power accelerators and cyclotrons, with leading biomedical research institutes and hospitals active in the translation of the emerging radionuclides into medical diagnosis and treatment.  PRISMAP will create a single-entry point for a fragmented user community distributed amongst universities, research centres, industry and hospitals, in a similar way as the National Isotope Development Center NIDC supported by the Department of Energy (DOE) has provided radionuclide sources for users in the USA. PRISMAP brings together a consortium of 23 beneficiaries from 13 countries, one European Research Laboratory and an International Organisation. It further receives support of leading associations and institutions in the field such as the European Association of Nuclear Medicine (EANM) and the International Atomic Energy Agency (IAEA).  Our main goal is to provide a sustainable source of high purity grade new radionuclides for medicine, involving from the onset upcoming major European infrastructures, to provide a single-entry point for all researchers active in this field including SMEs, global pharma, nuclear centres, hospitals and universities, using standardised access procedures. The new isotope enrichment and standardisation techniques triggered in PRISMAP will expand our services and provide them to yet unreachable remote European laboratories. PRISMAP thus strives to create a paradigm shift in the early phase research on radiopharmaceuticals, targeted drugs for cancer – one of the major diseases in Europe - theranostics and personalised medicine, shaping the European isotope landmark as a gold standard to accelerate the development of the pharma industry and ultimately of a better healthcare for the improvement of our citizens’ life.
Memory Park: a project for the recovery and fruition of First World War historical memory

The current project aims at setting up an area dedicated to the conservation of the historical evidence concerning the events that, during the First World War, took place in the Karst area in Slovenia and around Gorizia. After the end of the European cofinancing period, all the interventions should be integrated in and extended to the Austrian-Italian front, in order to develop a consistent enhancement of the common historical heritage. The memory park is intended as a shrine to a precious historical heritage, but its role is more important still from an educational point of view; moreover, one should not forget the possible use of the territory on the part of tourists and of the local population. Whilst recovering, enhancing and promoting the territory in a historical and cultural framework, the initiative creates a cultural tourism system, highlighting the landscape and several natural and archaeological sites involved in the project. The initiative serves also as a warning to future generations, so that these places - marked by the tragedies of the war - may foster a peaceful dialogue among peoples, especially in the framework of Community integration and of the eastward enlargement of the European Union. The intervention has several different aspects: the enhancement of the sites in a crossborder framework (thanks to the renovation work on the paths and the placing of signboards); a promotion work, through the dissemination of information on multimedia supports; the creation of an informative web site; the production of a promotional video.
Symmetries and degrees of freedom in cosmic epochs of accelerated expansion

Through theory and observations, it is well established that the universe undergoes accelerated expansion in its history. This accelerated expansion takes place in two different epochs. The first of these is the early epoch of inflation and the second is the current epoch of dark energy domination. Although methods of General Relativity, which is the classical theory of gravity, and Quantum Field Theory, which addresses matter interactions at quantum scales, have guided much of our understanding of the universe, they cannot fully address these epochs of accelerated expansion.

In this project the objective is to identify the cosmological degrees of freedom that have a crucial role during inflation and dark energy. It proposes to achieve this goal by studying the ideal case of a spacetime that gives accelerated expansion, using recent methods in holography in order to (i) identify specific deformations from the ideal case that give rise to the cosmological degrees of freedom during inflation and dark energy separately; (ii) explore the generality of these deformations and their cosmological consequences using methods of renormalization group flows; (iii) address deformations in the context of time dependent and space dependent evolution separately to further improve the understanding on the nature of cosmological degrees of freedom.

This interdisciplinary project proposes to use the principle of holography from String Theory which can open up a new way of studying cosmological perturbations, especially in the context of dark energy. By focusing on cosmological spacetimes, it will also address the validity of holography in new settings.
Recurrent pyoderma with Malassezia and hyperadrenocorticism in a dog.

A dog was referred to the College Hospital of College of Veterinary Science, Tirupati with a history of recurrence of skin problems for the past one year despite the treatment with different antibiotics alongwith corticosteroids at different dose rates without complete relief. Clinical examination revealed skin lesions all over the body with mild enlargedment of abdomen. Laboratory examination revealed cocci; neutrophils and Malassezia, suggestive of pyoderma associated with Malassezia. Staphylococcus intermedius and Klebsiella sps. were revealed upon cultural sensitivity test (CST) studies. Dog had mild anaemia, elevated cholesterol, alkaline phosphatase (ALP) and alanine aminotransferase (ALT) but normal total T4 (3.8 μg/dL) and free T4 (1.85 ng/dL). Further anamnesis based on biochemical analysis revealed polyuria and polydipsia also, suggestive of presence of hyperadrenocorticism. Dog was successfully treated with enrofloxacin and ketoconazole.
Sistema de información geográfico para visualización y consulta de datos del servicio de inserción social y del ayuntamiento de Barcelona

This paper presents the development work done in a geographic information system as a final project of the Master of Geographic Information Technologies. The system is made to and with the collaboration of the
company PROGESS and enable to the enterprise’s customers watch the results of the reports submitted by the street educators through a browser and Internet connection. It also aims to serve as reference for other similar projects and as a support tool for future changes or updates that wish to apply on the
system performed.
Throughout the document will show the phases of system development from its definition, objectives statement and design, implementation, operation and testing results. Finally, some conclusions will contribute to the work done.
PROCESS FOR THE PREPARATION OF 3,5-DICHLOROPYRIDINE

A process for the preparation of 3,5-dichloropyridine comprising reacting a trichloropyridine, a tetrachloropyridine or pentachloropyridine with zinc metal, in the presence of an acidic compound and at a temperature in the range 50-120 DEG C.
Individualized binaural diagnostics and technology

Humans have two ears – and for good reason: So-called binaural hearing is critical not only for localizing acoustic events but also for selectively focusing on a target sound while suppressing sound from other directions. In order to perform these tasks, neural circuits with the most temporally precise processing within the entire nervous system have evolved.
360 million people have impaired hearing. Although hearing aids and cochlear implants help restore audibility, they provide insufficient benefit in restoring the advantages of true binaural hearing.
IBiDT is designed to fundamentally change this perspective. Appreciating the individual nature of each hearing deficit, it will provide the means of diagnosing pathologies, not just the perceptual symptoms. IBiDT will suggest algorithms specific to the individual detailed patient profile and suggest therapeutic interventions specific to the listening situation. To achieve these aims, a multidisciplinary approach in which both auditory and non-auditory aspects of patient profiles and a computer model simulating the impaired auditory system will, together, transform diagnosis of hearing impairment from one concerned with audibility to one concerned with effective communication in any listening environment. Binaural hearing is an ideal conceptual framework in which to investigate this approach as it increases greatly the number of possible pathologies, compared to unilateral diagnostics.
The binaural hearing system is also ideal to investigate because it allows for large improvements in listening performance. Despite significant R&D expenditure, cochlear-implant performance has plateaued over the last 15 years, at least with respect to unilateral devices. Improvements from Individualized Binaural Diagnosis and Technology will have a large, positive impact on the increasing number of bilateral cochlear implant users (many of them children), as well as on the many tens of millions of people who use hearing aids.
Systematic models for biological systems engineering training network

Mathematical, computational models are central in biomedical and biological systems engineering; models enable (i) mechanistically justifying experimental results via current knowledge and (ii) generating new testable hypotheses or novel intervention methods. 

SyMBioSys is a joint academic/industrial training initiative supporting the convergence of engineering, biological and computational sciences. The consortium's mutual goal is developing a new generation of innovative and entrepreneurial early-stage researchers (ESRs) to develop and exploit cutting-edge dynamic (kinetic) mathematical models for biomedical and biotechnological applications. SyMBioSys integrates: (i) six academic beneficiaries with a strong record in biomedical and biological systems engineering research, these include four universities and two research centres; (ii) four industrial beneficiaries including key players in developing simulation software for process systems engineering, metabolic engineering and industrial biotechnology; (iii) three partner organisations from pharmaceutical, biotechnological and entrepreneurial sectors. SyMBioSys is committed to supporting the establishment of a Biological Systems Engineering research community by stimulating programme coordination via joint activities. 

The main objectives of this initiative are: 

* Developing new algorithms and methods for reverse engineering and identifying dynamic models of biosystems and bioprocesses

* Developing new model-based optimization algorithms for exploiting dynamic models of biological systems (e.g. predicting behavior in biological networks, identifying design principles and selecting optimal treatment intervention)
 
* Developing software tools, implementing the preceding novel algorithms, using state-of-the-art software engineering practices to ensure usability in biological systems engineering research and practice 

 * Applying the new algorithms and software tools to biomedical and biological test cases.
Project Administration for Design-Build Contracts: A Primer for Owners, Engineers, and Contractors

This book explains the basics of administering a design-build project after the contract has been awarded. It breaks the process into a series of learning modules that explain the component steps. It begins with an introduction to design-build project administration and goes on to cover topics such as scheduling, design administration, and design quality management. The authors examine construction topics including quality management, change orders, progress payments, and close-out. This practical guide provides case studies, often drawn from the authors' own experiences. This book is a resource for owners, engineers, construction contractors, and architects who find themselves in need of guidance in administering a design-build project. It will assist those professionals who actually do the designing, the building, and the contract administration. It organizes the options so that the advantages and disadvantages are highlighted, providing the user the necessary information to make sound business decisions.