SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
RESEAU TRANSFRONTALIER DE DEMOUSTICATION ET DE LUTTE ANTI-VECTORIELLE

The project REDLAV aims to improve the governance in the management of the means of combating anti-vector and a crisis of epidemic through the creation of institutional networks of local authorities in the territory for a common approach to reduce discomfort in relation to natural environments.
 Today, every region in the border region runs its own policy on the issue of the anti-vector and it seems essential to define a common project:
 • develop a common strategy with the definition of cross-border actions against the principles of sustainable development and ecological
 • study the conditions of establishment of a common system of prevention through the establishment of a monitoring cross-border entomological monitoring to improve the fight against vector-
 The objective is to develop cross-border cooperation and create a cordon of utilities to develop a shared strategy for the creation of common methodological tools, streamline and make more effective actions to prevent risks in the fight against vector in a process of applied ecology to reduce pollution and improve the conservation of natural environments.
St. bernard - emergency eeg and auditory evoked potentials for earlier diagnostics and treatment planning of unconscious patients

An ambulance crew is dispatched to help an unconscious man lying in the street. Is he having a stroke? Is he haemorrhaging in the brain? Has he hit his head? Is he an epileptic? Should the crew start thrombolytic treatment, stabilize the patient or give benzodiazepine? What next? These decisions need to be made every minute, every day around the world by first aid response units.

Brain-related injuries and dysfunctions cause high costs to society. The earlier the patient can be diagnosed, the more optimised the treatment path is, and the treatment outcome improves. All this saves money and time in one of the most expensive treatments and rehabilitation.

Mega Electronics has developed a solution for emergency brain (EEG) monitoring and plans to develop it into a new business concept. The concept allows easy-to-use, sub-hairline emergency EEG and auditory evoked potential (AEP) recordings and continuous monitoring during the entire patient care chain from emergency scene to hospital. 

The recorded EEG signals (and biomarkers extracted from them) can be visualized and monitored both locally and remotely, even during medical imaging. Previous studies have proven excellent signal quality. Future challenges lie in expanding the signal information content while maintaining ease-of-use for emergency situations and in inclusion of AEP monitoring.

The product consists of an innovative, easy-to-use electrode strip, wireless transmission module and a remote monitoring system. No equivalent solutions are in the market yet. Users are medical professionals working in ambulances, hospitals and health care centres.

Feasibility assessment (phase 1) will develop the business concept, study the benefits of AEPs in emergency medicine, plan the technical modifications needed to current products, plan the validation measurements (for phase 2) and assess the risks of the system. Mega has a dealer network of 32 companies covering all continents and can start sales right away.
CALIBRATION OF ELECTRICAL PARAMETERS IN OPTICALLY SWITCHABLE WINDOWS

The embodiments herein relate to methods for controlling an optical transition and the ending tint state of an optically switchable device, and optically switchable devices configured to perform such methods. In various embodiments, non-optical (e.g., electrical) feedback is used to help control an optical transition. The feedback may be used for a number of different purposes. In many implementations, the feedback is used to control an ongoing optical transition. In some embodiments a transfer function is used calibrate optical drive parameters to control the tinting state of optically switching devices.
Clinical study on rTMS facilitating motor functions recovery under the guidance of fMRI in cerebral infarction patients

【Objective】To explore the therapeutic effects of repetitive transcranial magnetic stimulation(rTMS) guided by fMRI on rehabilitation of motor functions in patients after cerebral infarction.【Methods】fifty patients(28 males and 22 females with acute cerebral infarction of right corona radiata were selected. They were randomly allocated into 5 groups(10 in each group). All subjects accepted the same basic therapy. Hotor function of the affeced hand of patient in the treatment groups(group A-D) was evaluated with Fugl-Meyer scale(FMA) before and after r7MS and 90 days later. General status of neurological deficiency and activities of daily living of all patients were assessed with National Institute of Health stroke scale(NIHSS) and Barthel index(BI).【Results】The FMA and BI of all treated groups 14d and 90d after treatment were significantly different as compared with before treatment(P0.05). The NIHSS of90d were significant different as compared with before treatment(P0.05).【Conclusion】Stimulating the contralateral M1 area with rTMS under the guidance of fMRI may improve the hand motor function, recover the neurological deficiency and activity of daily living of the patients with cerebral infarction.
Effects of surroundings snow coverage and solar tracking on photovoltaic systems operating in Canada

This paper deals with demonstrating the energy performance of solar tracking photovoltaic (PV) systems in Canada. In this study, a grid connected stand-alone PV system has been designed and coupled with four different tracking systems: fixed horizontal, fixed tilted, single-axis tracking, and dual-axis tracking. The performance analysis of the systems focuses on the variation of array irradiance, electricity generation, and efficiency without considerations for economic impacts at this stage. The simulation results show that the dual-axis tracking array provides the best performance over a year. It receives 33% more solar radiation and generates 36% more electricity than the tilted system. On clear winter days, compared to the tilted system, the dual-axis tracking system produces 32% and 29% more electricity in high albedo and low albedo conditions, respectively. High albedo due to surroundings snow coverage has been found to cause an increase of 3.1%, 5.8%, and 7.9% in electricity production of the tilted, single-axis tracking, and dual-axis tracking system respectively, over a winter. The results of this research support the idea that tracking the sun is effective on clear days and could be counterproductive on overcast days. Therefore, in high albedo conditions, it is recommended to track the sun and stay fixed once the sky becomes overcast.
Health Neuroscience

Health neuroscience is a new field that is at the interface of health psychology and neuroscience. It is concerned with the interplay between the brain and physical health over the life span. A chief goal of health neuroscience is to characterize bidirectional and dynamic brain-behavior and brain-physiology relationships that are determinants, markers, and consequences of physical-health states across the life span. The motivation behind this goal is that a better understanding of these relationships will provide mechanistic insights into how the brain links multilevel genetic, biological, psychological, behavioral, social, and environmental factors with physical health—especially vulnerability to and resilience against clinical illnesses. This review provides a conceptual introduction to health neuroscience, focusing on its major themes, representative studies, methodologies, and future directions.
Structural studies of na,k-atpase isoforms and mutants

Isoform complexes of Na,K-ATPase , an αβ-heterooligomer, have recently been identified as crucial regulators of muscle and neural physiology and were furthermore identified as the primary cause of neurological diseases. Of particular interest are α2β2 & α2β3, which are expressed in muscle and astrocytes (α2β2) and the ciliary body (α2β3). Both exhibit a significantly lower affinity for K-ions and a steeper voltage dependence than the housekeeping α1β1 complex. These features keep α2-isoforms inactive at resting conditions but allow to respond to transient elevations of extracellular K after muscle and neuronal activity. Moreover, both complexes can be selectively inhibited by cardiac steroids, making them promising drug targets for the treatment of heart failure (α2β2) and glaucoma (α2β3). Differences in affinity for K and cardiac steroids were attributed to the β-subunit recently, yet the root cause and molecular details remained elusive. Hence, I propose to investigate the structure of α2-isoforms purified from the yeast Pichia pastoris by x-ray crystallography and cryo electron microscopy. In addition to its physiological and pharmacological role mutations of Na,K-ATPase cause severe neurological diseases, e.g. Alternating Hemiplegia of Childhhod. Disease mutations typically inactivate the Na-pump causing severe motor and cognitive disorder. However, the effects of mutations on the ATPase’s reaction cycle have not been investigated in detail, leaving the cause of inactivation in the dark. Part two of the proposal addresses this gap of knowledge. The two most common mutations E815K and D801N will be expressed in P. pastoris and the effect of mutations on partial reactions of the Na,K-ATPase’s reaction cycle will be investigated and subsequently, structural studies will be carried out. This work will promote our understanding of Na,K-ATPase in health and disease and lay the foundation for the development of new drugs.
Study of multiferroic properties of Bi2Fe2WO9 ceramic for device application

The Bi 2 Fe 2 WO 9 ceramic was prepared using a standard solid-state reaction technique. Preliminary analysis of X-ray diffraction pattern revealed the formation of single-phase compound with orthorhombic crystal symmetry. The surface morphology of the material captured using scanning electron microscope (SEM) exhibits formation of a densely packed microstructure. Comprehensive study of dielectric properties showed two anomalies at 200[Formula: see text]C and 450[Formula: see text]C: first one may be related to magnetic whereas second one may be related to ferroelectric phase transition. The field dependent magnetic study of the material shows the existence of small remnant magnetization ([Formula: see text]) of 0.052[Formula: see text]em[Formula: see text]/g at room temperature. The existence of magneto-electric (ME) coupling coefficient along with above properties confirms multi-ferroic characteristics of the compound. Selected range temperature and frequency dependent electrical parameters (impedance, modulus, conductivity) of the compound shows that electric properties are correlated to its microstructure. Detailed studies of frequency dependence of ac conductivity suggest that the material obeys Jonscher’s universal power law.
Searching for X-ray sources in nearby late-type galaxies with low-star formation rates

Late type non-starburst galaxies have been shown to contain X-ray emitting objects, some being ultraluminous X-ray sources. We report on XMM-Newton observations of 11 nearby, late-type galaxies previously observed with the Hubble Space Telescope (HST) in order to find such objects. We found 18 X-ray sources in or near the optical extent of the galaxies, most being point-like. If associated with the corresponding galaxies, the source luminosities range from $2 \times 10^{37}$ erg s$^{-1}$ to $6 \times 10^{39}$ erg s$^{-1}$. We found one ultraluminous X-ray source, which is in the galaxy IC 5052, and one source coincident with the galaxy IC 4662 with a blackbody temperature of $0.166 \pm 0.015$ keV that could be a quasi-soft source or a quiescent neutron star X-ray binary in the Milky Way. One X-ray source, XMMU J205206.0$-$691316, is extended and coincident with a galaxy cluster visible on an HST image. The X-ray spectrum of the cluster reveals a redshift of $z = 0.25 \pm 0.02$ and a temperature of 3.6$\pm$0.4 keV. The redshift was mainly determined by a cluster of Fe XXIV lines between the observed energy range $0.8-1.0$ keV.
In situ light irradiated perovskite nmr

Widespread adoption of photovoltaics for clean, plentiful and renewable energy requires cheap, efficient and long-lasting solar cells; hybrid perovskite solar cells are promising candidates but suffer from light-induced degradation under operational conditions. Chemical understanding of the photodegradation processes is required to develop stable materials, but is challenging to obtain with existing techniques. Here we propose to study perovskite degradation under in situ light irradiation using high-resolution solid-state NMR. Solid-state NMR is an atomic-scale, element-specific probe of local structure which has recently been shown to provide important information on perovskite systems, however new methodology is required to perform in situ light irradiation. Significantly, many photodefects will be present at low concentrations and/or localised at surfaces; in order to observe these by NMR, in situ light irradiation will be combined with dynamic nuclear polarisation (DNP), whereby the greater polarisation of unpaired electrons boosts the NMR signal. The project is split into three parts: (1) observation of major perovskite photodegradation products under in situ light irradiation that do not require additional sensitivity; (2) adaptation of DNP NMR to perovskites to observe surface passivating species; and (3) combined DNP-enhanced, in situ light-irradiated NMR to observe minor and/or surface photodefects. All three parts represent innovative methodological advances and will provide key chemical information on perovskite structures and degradation processes to guide future development of stable solar cells. The combination of myself and the Emsley lab is ideal to perform this project, through which I will develop the advanced technical and non-technical research skills required for the project to be succesful. The fellowship will expand my international network and result in wide-reaching research output, which will establish me as an independent researcher.
Van-based robot hybrid pickup and delivery routing problem

HAL is a multi-disciplinary open access archive for the deposit and dissemination of scientific research documents, whether they are published or not.The documents may come from teaching and research institutions in France or abroad, or from public or private research centers.L'archive ouverte pluridisciplinaire HAL, est destinée au dépôt et à la diffusion de documents scientifiques de niveau recherche, publiés ou non, émanant des établissements d'enseignement et de recherche français ou étrangers, des laboratoires publics ou privés. Van-based robot hybrid pickup and delivery routing problem
Steigerung der Wettbewerbsfähigkeit des Unternehmens METAL-TECHNIKA durch die Einführung eines innovativen Produkts in Form einer optimierten Maschine für Holz- und Schneidfehler von Holz mit Schrägschnitt.

Der Antragsteller beschreibt kurz die wichtigsten Fragen rund um das Projekt, unter anderem Ziele, Aufgaben, Zielgruppen Das Projekt besteht aus dem Bau eines neuen Produktionsgebäudes, dem Kauf einer hydraulischen Presse, einem Portal von 2 Stück Schweißmaschinen und der Herstellung von Sachanlagen in Form von zwei Laserbrennern, die das Material in 3D-Technologie schneiden, eines für das Profil und das andere für Flachplatten. Daher kauft das Unternehmen: 6 und 8 KW Laserresonatoren, Laser 2 Stück 3D Schneidköpfe, Software und Steuerungssysteme für gebaute Ausrüstung. Laserbrenner, die vom Antragsteller hergestellt werden, zeichnen sich durch moderne Laserschneidverfahren aus, die von konkurrierenden Unternehmen nicht verwendet werden. Produktinnovationen werden durch die Umsetzung des Projekts und der eingesetzten Technologie erreicht. Als Ergebnis der Operation plant das Unternehmen, ein neues Produkt in Form eines Geräts zur Optimierung von Holzschnitt- und Schneidfehlern mit diagonalem Schneiden einzuführen, das im Vergleich zu den derzeit auf dem Markt angebotenen Geräten deutlich verbessert wird. Dieses Produkt ist neu und derzeit nicht auf dem Markt. Die Einführung eines neuen Produkts wird es dem Unternehmen ermöglichen, zusätzliche Gewinne zu erzielen und so seine Wettbewerbsfähigkeit im In- und Ausland zu steigern. Die Einführung eines neuen Produkts wird die Position des Marktführers im Vertrieb von Optimierern auf dem heimischen Markt stärken und es METAL-TECHNIKA ermöglichen, Expansionen auf ausländischen Märkten, insbesondere auf dem deutschen Markt, aufzunehmen. Die Durchführung des Projekts wird es ermöglichen, den aktuellen Investitionsbedarf zu decken. Für den Kauf des Geräts geplant ist ausreichend, um die für das Projekt geplanten Output-Indikatoren zu erreichen. Die Umsetzung der Investition wird auch zu einer Änderung der Organisationsstruktur des Unternehmens führen. Die Einführung eines neuen Produkt- und Produktionsprozesses erfordert eine Erhöhung der Beschäftigung in der Produktionsabteilung
DRUGGABLE MM THERAPEUTICS: PATHOGENETIC PATHWAYS

In the current treatment scenario, after 1, 2 or at most 3 lines of therapy, most MM patients have exposed (or are refractory), to PIs, IMiDs and anti-CD38 MoAb. Novel alternatives are currently being developed, mostly using BCMA as a target, and some of them such as CAR-Ts or ADCs have already been approved although they are still not widely available, at least in Europe. But there is still an active search for novel therapeutic options based on the MM pathogenetic vulnerabilites. One such mechanism, although not novel, is DNA damage, and Melflufen, a Peptide-Drug conjugate (PDC) showed activity in heavily pretreated patients, what led to its initial FDA approval, although, significant concerns about long term toxicity have been raised in the phase III study. Selinexor inhibits XPO-1, a protein that exports different proteins from the nucleus of the tumor cell. In combination with dexamethasone, it has demonstrated activity in penta-refractory or triple-class refractory patients, with an ORR of 26% and a DOR of 4 months, that lead to its FDA and EMA approval. Another important target is the E3 ubiquitin ligase CRBN, and in fact, two CELMoDs (CRBN modulators), Iberdomide (CC-220) and CC-92480, have demonstrated activity (ORR 30-50%) and a favorable safety profile in heavily pretreated patients. MM cells are also largely dependent on the antiapoptotic molecule Bcl2, and venetoclax, an inhibitor of this protein, has demonstrated to be active particularly in patients carrying t(11;14). More recently, several Mcl-1 inhibitors are also being evaluated both preclinically and clinically. Another interesting target could be the RAS pathway as it is mutated in around 50% of MM patients and RAS/RAF/MEK inhibitors have demonstrated activity in selected patients populations. Other approaches are also attractive such as myc inhibition or additional ways of activating the immune system. In this last field, two novel mechanisms hold significant promise: inhibition of the do not eat me signal with anti-CD47 MoAb such as Magrolimab, or the use of Modakafusp a CD38 MoAb with two IFN attenuated molecules that induces a anti-tumoral One important field of investigation is the search for biomarkers predicting sensitivity or resistance to a given agents, such as venetoclax in t(11;14) patients, Mcl-1 inhibitors in patients with 1q+, or RAS/RAF/MEK inhibitors for patients with activation of this pathway.
Indentation and Friction of Cu<sub>44</sub>Zr<sub>43</sub>Al<sub>10</sub>Nb<sub>3</sub> Bulk Metallic Glasses on Nano-Scale

Indentation and sliding friction of the as-cast, the relaxed and the crystallized Cu 44 Zr 43 Al 10 Nb 3 bulk metallic glass (BMG) are investigated on nanoscale by nanoindentation. The depth, the width and the morphology of the scratches formed by the tip of the nanoindentor are different, which reflect the differences in structure, not only between the glassy and the crystallized states but also between the two glassy states, the as-cast and the relaxed. The coefficient of sliding friction of Cu 44 Zr 43 Al 10 Nb 3 BMG is increased with increasing the load, and it is maximal for annealed at 683K. Improved plastic deformability is found for the relaxed one.
Smart laser diode array assembly

A laser diode array assembly includes a laser diode array and a memory device integrally packaged with the array. The memory device includes operational information concerning the array. The memory device is accessible by a host external operating system which determines the manner in which the array is to be powered based on the operational information. The memory device may have the capability to be written to such that the external operating system can record in the memory device significant events such as extreme operational conditions, operational faults, and the on-time or shot- count of the array. The assembly may include sensors to which the operating system is coupled. The assembly may further include a processing means to monitor the sensors and provide real-time updates to the external operating system such that laser diode array is continuously powered in an optimal manner.
Programa ADAPTAR

Aquisição de Equipamentos de aspiração, transformação de layout para melhorar lavagem de materiais e aquisição de ferramentas informáticas de informação, interação com clientes e agendamento.
A brief history of time, space, and growth: Waldo Tobler’s first law of geography revisited

In the current knowledge economy, the most important production factor, human knowledge, is much more mobile than the dominating production factors of previous periods. This means that theories of spatial development, formulated during the manufacturing-industrial era, might not be wholly applicable today. One of the basic assumptions of spatial theory is formulated in Waldo Tobler’s first law of geography: “everything is related to everything else, but near things are more related than distant things.” This article discusses the validity of this law in today’s knowledge economy. While several factors have made distance less important, a crucial factor for innovation and growth—tacit knowledge—is still highly dependent on face-to-face contacts. This suggests that Waldo Tobler’s first law of geography plays an important role also in the knowledge economy.