SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Ultra-Small electrochemical aptasensors for specific dopamine real-time monitoring

Nowadays, over 1.2 million people in Europe live with Parkinson’s disease (PD) considered as a complex disorder of unknown etiology, where an important number of cases are sporadic. In practice, the neurodegeneration associated with PD, also at the level of neurotransmitters (NT) misbalance, starts several years prior to the appearance of the cardinal symptoms. There are important evidences supporting that some environmental factors increase the risk of developing PD. Thus, there is the need of understanding their role and action mechanisms in order to develop therapeutic strategies and, even more important to minimize risks of PD development.
The main aim of this project is to develop an ultra-small electroanalytical diagnostic platform for highly-specific real-time monitoring of NT, such as dopamine (DA). Several methods have been developed in order to address this issue, but in general they lack either specificity or high spatial/temporal resolution. In this project we propose to exploit the ability of nucleic acid aptamers to sensitively and selectively bind/catalytically transform DA and develop an ultra-small array platform for DA monitoring in small biological environments. The importance is that it will be used to measure nM/μs DA release from PC12 cells and drosophila flies, examine the molecular mechanisms of neuronal function/dysfunction, and further correlated them to particular PD risk factors.
In a long-term perspective, the project aims microscopic sensors that may future be integrated with brain implants designed to restore local neuronal activity and/or NT release, such as deep brain stimulation electrodes, implanted to treat PD.
Predicting giant panda habitat with climate data and calculated habitat suitability index (HSI) map

Climate data are particularly important in Species Distribution Models (SDMs) that are used for predicting global warming consequences on plant and animal distributions. A number of the plants and animals, especially the endangered species such as the giant panda (Ailuropoda melanolecua), are limited in their scope of distribution due to climate changes. Thus, predicting the habitat quality distribution under climate change is important for protecting these species. In this paper the existing and potential habitats of the giant pandas are used as the study area, the calculated Habitat Suitability Index (HSI) maps in 1989 and 2002, and climate change data in 1989, 2002, 2050 and 2099 from the IPCC are used as the data sources. A multivariable linear regression model for mapping HSI is created with the regressive results in 2002 and 1989. The HSIs of the study area in 2050 and 2099 were then mapped with the model. These maps indicate that, from 2002 to 2050, about 2.64% of the unsuitable habitat in the study area will become suitable, while about 1.5% of the suitable habitat will turn into unsuitable habitat. This leads to an increase of the suitable habitat area on the whole from 2050 to 2099: about 3.43% of the unsuitable habitat will become suitable, while about 6.59% of the suitable habitat will turn into unsuitable habitat, which leads to a decrease of the suitable habitat area on the whole. From the suitable habitat distribution, it can be seen that the suitable habitat of giant pandas gradually moves north under projected global climate change. Copyright © 2013 Royal Meteorological Society
Open method of co-ordination fordemoi-cracy? Standards and purposes

ABSTRACTUnder which conditions does the open method of co-ordination match the standards for demoi-cracy? To answer this question, we need some explicit standards about demoi-cracy. In fact, open co-ordination serves three different but interrelated purposes in European Union policy: to facilitate convergence; to support learning processes; and to encourage exploration of policy innovation. By intersecting standards and purposes, we find open co-ordination is neither inherently ‘good’ nor ‘bad’ for demoi-cracy, as it depends on how it has been put into practice. Therefore, we qualify the answer considering the empirical evidence on how normative principles hit the road of implementation. In the final part of this paper, we look into the demoi-cratic effects of the Eurozone's economic and financial crisis on our findings.
Una especie introducida en humedales, ¿posible invasora? Distribución de Potentilla anserina (Rosaceae) en el Parque Nacional Nahuel Huapi (Patagonia, Argentina)

Introducción y objetivos: Los humedales son ecosistemas naturales relevantes para la biodiversidad y aseguran una variedad de servicios ecosistémicos. Sin embargo, son ambientes susceptibles a las invasiones de especies. La especie introducida e invasora Potentilla anserina se encontró en humedales de la Patagonia. Los objetivos de este estudio fueron determinar la distribución de esta especie en el Parque Nacional Nahuel Huapi y conocer como se relaciona con los tipos de hábitats y usos del suelo. M&amp;M: Estudiamos la distribución de P. anserina en 28 humedales a lo largo de un gradiente de precipitaciones (55,4 km Este-Oeste), en el Parque Nacional Nahuel Huapi, en relación con el tipo de ambiente, hábitat, grado de urbanización, presencia de ganado. También, relacionamos su cobertura con la riqueza de especies en 8 de los mallines analizados. Resultados: P. anserina estuvo correlacionada con humedales someros y temporarios y con la presencia de ganado. La cobertura de P. anserina no superó el 10% (con una excepción) y no estuvo relacionada con la riqueza de especies. Conclusión: Debido a la alta capacidad de dispersión de P. anserina en humedales patagónicos y la alta cobertura observada en uno de los mallines estudiados, nuestros resultados alertan sobre el potencial invasor de esta especie introducida.
Improvements in or relating to air pressure operated apparatus

944,223. Fluid-pressure brakes. CLAYTON DEWANDRE CO. Ltd. May 12, 1961 [May 18, 1960], No. 17554/60. Heading F2F. A fluid pressure vehicle brake servo-unit comprises two end-toend arranged piston and cylinder devices, one piston transmitting thrust to the other by means interconnecting the corresponding cylinder ends to provide unified additive thrust. A pair of cylinders 1, 2 are secured together to a flanged plate 3 by a split clamping ring 5. Admission of compressed air at 14 to the left of a piston 8 is communicated by ports 13, 15 and hollow piston rod 9 to the corresponding side of a second piston 10. The piston rod 9 abuts the piston rod 11 of piston 10 to provide additive thrust to the output stud 12. Return springs 8a, 10a respectively are provided for the pistons and filtered air is allowed to pass to the space behind the piston 8 through a breather 16. A breather for the piston 10 may be provided in a mounting stud.
Prediction of the drug release stability of different polymeric matrix tablets containing metronidazole

The aim of the present study was to predict the structural changes of polymeric excipients in the course of storage causing undesired changes in drug release stability of tablets containing different polymers. Matrix tablets were formulated with metronidazole as a model drug, using polyvinylpyrrolidone and carbopol as matrix materials. Dissolution tests were carried out before and after storing the tablets under stress conditions for different time intervals. Parameters characterizing the release kinetics of matrix tablets, just as difference and similarity factors, were calculated to compare the release profiles as a function of storage time. FT-IR measurements were carried out to track the structural changes of the physical mixtures of metronidazole and polymers during storage. The changes of the characteristic peaks of the FT-IR spectra of metronidazole-polymer mixtures were in good correlation with the significant changes of release parameters of tablets. The latter was confirmed by ab initio calculations. The work showed that the combination of ab initio calculations with structural examinations could predict the possible instability of drug release and, thus, enables the screening of polymeric excipients of undesired physical stability.
Integration of rna biology for next-generation scientists

While there are ever-increasing interconnections and integration across CEITEC MU research programs as well as across different scientific fields in nearby faculties, most of the research is still performed within the boundaries of individual laboratories or research programmes. The CEITEC groups involved in this proposal have diverse research interests however they are all connected by the same fiber- RNA. The overarching aim of this project proposal is integration of these groups at the level of methodological approaches, research questions and training of young scientists. In addition, empowering excellence in science and training, research management and boosting institutional recognition will position CEITEC MU as an RNA excellent research cluster. We plan to achieve our aims through close collaborations in joint research, increased mobility of researchers, ESRs and research management staff and increase the impact through dissemination of the results at a local, national and international level. The Twinning partnerships will help create a synergistic environment enabling CEITEC MU to have the confidence and expertise to establish an excellence RNA cluster with a Europe-wide network and competitive technologies, while heading for the future of excellence.
A Novel Resistor-Free Electronically Adjustable Current-Mode Instrumentation Amplifier

In this paper, a novel topology for implementing resistor-free current-mode instrumentation amplifier (CMIA) is presented. Unlike the other previously reported instrumentation amplifiers (IAs), in which input and/or output signals are in voltage domain, the input and output signals in the proposed structure are current signals and signal processing is also completely done in current domain benefiting from the full advantages of current-mode signal processing. Interestingly the CMRR of the proposed topology is wholly determined by only five transistors. Compared to the most of the previously reported IAs in which at least two active elements are used to attain high common-mode rejection ratio (CMRR) resulting in a complicated circuit, the proposed structure enjoys from an extremely simple circuit. It also exhibits low input impedance employing negative feedback principal. Of more interest is that, using simple degenerate current mirrors, the differential-mode gain of the proposed CMIA can be electronically varied by control voltage. This property makes it completely free of resistors. The very low number of transistors used in the structure of the proposed CMIA grants it such desirable properties as low-voltage low-power operation, suitability for integration, wide bandwidth etc. SPICE simulation results using the TSMC 0.18-μm CMOS process model under supply voltage of ±0.8 V show a high CMRR of 91 dB and a low input impedance of 291.5 Ω for the proposed CMIA. Temperature simulation results are also provided, which prove low temperature sensitivity of the proposed CMIA.
C2 advanced multi-domain environment and live observation technologies

The creation of the Schengen area has been one of the major achievements of the EU. However, this agreement requires countries to cooperate tightly in order to keep a high level of security at their internal borders, as well as to share the responsibility of managing external borders. Such a variety of borders (land, sea and air) and current challenges requires a consistent approach to border surveillance, based on a plethora of heterogeneous assets. These can be manned or unmanned, ranging from sensors (optical, radar, IR) to unmanned platforms (UAV, UGV, USV or UUV), and need to be combined to offer an integrated situational picture of the area under surveillance and of their location. In order to effectively control their operation and manage the large amounts of data collected by them, new approaches for command and control need to be considered, allowing efficient interaction between the operator and the different assets in the field. CAMELOT proposes to develop and demonstrate different advanced command and control service modules for multiple platform domains, based on a SOA architecture that specifies internal and external interfaces, allowing the development of a modular and scalable command and control station, customisable to the user needs. This architecture can be based on results of previous studies and work or open architectures that may prove more suitable and the interfaces can take advantage of the standardisation work that has been done already. After the definition, CAMELOT partners will prototype service modules according to their expertise, background individual technologies and practitioner needs. These will be integrated progressively in specific testing along the project. This prototype development approach will culminate in 2 final demonstrations involving end users and relevant stakeholders, to achieve a maturity of TRL6 (for most individual technologies supporting the functionalities for border surveillance) and an IRL of 7 for CAMELOT.
Pressure contact assembly with a power output element, a metal casing and a connecting device

Die Erfindung beschreibt eine Druck kontaktierte Anordnung mit einem Leistungsbauelement, einer Verbindungseinrichtung und einem ersten Metallformkörper zur Wärmeabfuhr. Das Leistungsbauelement ist hierbei mit seiner ersten Hauptfläche dem ersten Metallformkörper zugewandt angeordnet und elektrisch leitend mit diesem verbunden Die zweite Hauptfläche ist mit einer Kontakteinrichtung der Verbindungseinrichtung elektrisch leitend verbunden ist. Ein Gehäuse umschließt das Leistungsbauelement und schließt mittels einer Dichteinrichtung zum ersten Metallformkörper und zur Verbindungseinrichtung hin ab. Eine Druckeinrichtung leitet Druck auf das Gehäuse und / oder die Verbindungseinrichtung in Richtung des ersten Metallformkörpers ein.
Optimising wetland restoration strategies to minimise methane emissions and maximise carbon uptake

The aim of the WETRES project is to determine the greenhouse gas fluxes from restored wetlands to see how fluxes change if drained and degraded wetlands are restored. Restoring degraded peat soils is an attractive, but largely untested climate change mitigation approach. Drained peat soils used for agriculture or for peat extraction are often large carbon dioxide sources and will contribute to global warming. Therefore, restoring subsided peat soils to managed, impounded wetlands can turn these sources into carbon sinks. However, at present, the amount of scientific information available to guide such restoration decisions and assess the impact of these actions is still sparse and restoration outcomes can be low carbon uptake and high methane emissions. Therefore, the overarching goal of this project is to provide an experimental and theoretical understanding of how to restore wetlands with minimised methane emissions and maximised carbon uptake. To understand processes that regulate carbon sequestration efficiency and methane fluxes, there is a need to cover fields from the molecular level to the ecosystem level. To achieve that, multiple drivers, such as site-specific hydrology, legacy effects, soil chemistry, soil microbiology, vegetation development will be analysed in conjunction with greenhouse gas emissions.   This effort directly addresses the European H2020 priorities of sustainable rural development and lower greenhouse gas emissions, which will help to slow down climate change.
Big-Data-Driven Control Strategies for Complex Networks

Spurred by the growth of the World Wide Web and the Internet, and their similarity to numerous other large, dynamic, real-life networks, a truly cross-disciplinary science of complex networks has emerged in the past 15 years [1-12]. Hundreds of studies have been conducted and papers published exploring properties of complex networks—such as, their size, diameter, degree distribution, pairwisedistance distribution, cliques, communities, clustering coefficient, and the like [5-11]. Several growth models of these evolving networks have been proposed and studied [5,6]. However, an area of active interest, which has not been studied adequately, is that of designing control policies to steer the evolution of such a network towards a desired goal [8]. In practical situations, such as controlling the spread of diseases or the formation of opinions, topological properties, of the network, may need to be controlled. It would, therefore, be valuable to have automated synthesis [7] of strategies for controlling relevant topological properties of complex networks described by, for example, a preferentialattachment and preferential-deletion model [6]. We propose that an automated optimal control of evolving complex networks be achieved by leveraging recent results in developing stochastic models for the evolution of complex networks in combination with the classical results on dynamic-programming algorithms for optimal control [2-4].
Multisensory Processing in Review: from Physiology to Behaviour

Abstract Research in multisensory processes has exploded over the last decade. Tremendous advances have been made in a variety of fields from single-unit neural recordings and functional brain imaging through to behaviour, perception and cognition. These diverse approaches have highlighted how the senses work together to produce a coherent multimodal representation of the external world that enables us to function better by exploiting the redundancies and complementarities provided by multiple sensory modalities. With large numbers of new students and researchers being attracted to multisensory research, and the multi-disciplinary nature of the work, our aim in this review is to provide an overview of multisensory processing that includes all fields in a single review. Our intention is to provide a comprehensive source for those interested in learning about multisensory processes, covering a variety of sensory combinations and methodologies, and tracing the path from single-unit neurophysiology through to perception and cognitive functions such as attention and speech.
ABSORBENT STRUCTURE AND ABSORBENT ARTICLE CONTAINING SAID ABSORBENT STRUCTURE

The present invention relates to an absorbent structure (1) and an absorbent article containing said absorbent structure. The absorbent structure (1), having a sequence (2) of layers connected together, comprises a first outer absorbent layer (3) made from airlaid material, a second outer absorbent layer (4) made from airlaid material, and a fluid storage layer (5) made from airlaid material arranged between the first and second outer absorbent layers, wherein the airlaid material of the first outer absorbent layer (3) comprises first cellulose fibres (6), the airlaid material of the second outer absorbent layer (4) comprises second cellulose fibres (16) and the airlaid material of the fluid storage layer (5) comprises third cellulose fibres (7) and super-absorbent components (8), wherein the first and second cellulose fibres (6, 16) have a lower pH value than the third cellulose fibres (7) and the pH value of the first and second cellulose fibres (6, 16) is less than 5.0.
Spin nematic phase in one-dimensional and quasi-one-dimensional frustrated magnets in a strong magnetic field

We discuss spin-1/2 one-dimensional (1D) and quasi-1D magnets with competing ferromagnetic nearest-neighbor $J_1$ and antiferromagnetic next-nearest-neighbor $J$ exchange interactions in strong magnetic field $H$. It is well known that due to attraction between magnons quantum phase transitions (QPTs) take place at $H=H_s$ from the fully polarized phase to nematic ones if $J>|J_1|/4$. Such a transition at $J>0.368|J_1|$ is characterized by softening of the two-magnon bound-state spectrum. Using a bond operator formalism we propose a bosonic representation of the spin Hamiltonian containing, aside from bosons describing one-magnon spin-1 excitations, a boson describing spin-2 excitations which spectrum coincides at $H\ge H_s$ with the two-magnon bound-state spectrum obtained before. The presence of the bosonic mode in the theory that softens at $H=H_s$ makes substantially standard the QPT consideration. In 1D case at $H<H_s$, we find an expression for the magnetization which describes well existing numerical data. Expressions for spin correlators are obtained which coincide with those derived before either in the limiting case of $J\gg|J_1|$ or using a phenomenological theory. In quasi-1D magnets, we find that the boundary in the $H$--$T$ plane between the fully polarized and the nematic phases is given by $H_s(0)-H_s(T)\propto T^{3/2}$. Simple expressions are obtained in the nematic phase for static spin correlators, spectra of magnons and the soft mode, magnetization and the nematic order parameter. All static two-spin correlation functions are short ranged with the correlation length proportional to $1/\ln(1+|J_1|/J)$. Dynamical spin susceptibilities are discussed and it is shown that the soft mode can be observed experimentally in the longitudinal channel.
A thz communication evaluation kit

The FASTERA evaluation kit is a THz receiver designed for next-generation 6G technology covering indoor and short-range environments. The FASTERA kit is intended to answer the increasing data-rate demand of current consumer and industrial markets. The THz evaluation kit goes beyond the capabilities of current 5G technology, enabling the exploitation of the THz frequency range for data communication applications. The FASTERA kit is based on a patented antenna-coupled graphene-enabled detector able to operate at room temperature, with high sensitivity (~80 pW/Hz1/2), fast response (>100 GHz), and broadband (from 100 GHz up to 5 THz) tuneable spectral range defined by the antenna itself. The FASTERA evaluation kit will be defined in collaboration with Ericsson and will be tested in a 6G communications testbed.
METHOD FOR TRANSCODING COLOURS ENABLING THE INTERCONNECTION OF TWO EQUIPMENTS FOR THE DEFINITION OF DIFFERENT COLOURS, AND TRANSCODER RELATED THERETO

The location of the character colour Cc in the interval Ci-Ci+1 of two successive colours of the output equipment and the location of the background colour Cj in the interval Cj-Cj+1 are determined. According to those locations, either Ci or Ci+1 is taken as the character colour and either Cj or Cj+1 is taken as the background colour. Application in videography and to computers, printers, etc....
A long-lasting non-migrating hydrogel for relieving chronic pain

Chronic Neuropathic Pain (NeP) is an enormous problem globally. Estimates predicate that 20% of adults suffer from pain world-wide and 10% are newly diagnosed with chronic pain annually1. According to the EuroPain Innovative Medicines Initiative (IMI)2, one in five adults in Europe suffers from chronic pain.  One type of Neuropathic Pain that is particularly detrimental to patients quality of life is Trigeminal Neuralgia (TN). The trigeminal nerve is responsible for facial sensory function, and trauma to this nerve can result in sudden, severe, stabbing and recurrent episodes of pain. Patients with TN experience a prolonged debilitating condition, where the pain is often described as one of the most painful conditions in medicine. TN is infamously called the “suicide disease” as there have been numerous suicide reports associated with the condition. Epidemiologists estimated the prevalence of chronic TN pain is also large at 7%3, which amounts to 36 million Europeans. Similarly, in the US, the American Association of Neurological Surgeons report that 150,000 people are diagnosed with TN every year with a prevalence of chronic TN impacting 1.7 % of population 4. Therefore in this  proposal, we describe the development of a long-lasting and drug-free treatment for chronic Trigeminal Neuralgia.