SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Chemical proteome mining for functional annotation of disease relevant proteins

Genome sequencing projects have provided unique insights into the cellular inventory of genes and their corresponding protein products. Despite this success, a large fraction of cellular proteins remains functionally uncharacterized. Their annotation represents a major challenge for contemporary research, reaching beyond the power of bioinformatic sequence similarity searches. Thus multidisciplinary strategies consolidating chemical and biological methods are required to close this gap. We here approach the challenge by two chemical proteomic platforms that focus on disease relevant sub-fractions of the uncharacterized proteome. The first platform utilizes functionalized cofactors that exploit cognate cellular uptake systems and report specific binding of large enzyme families. The molecules will be applied to mine cellular proteomes for unknown family members with crucial roles in diseases and assign their function. The second platform exploits phosphoaspartate as an important disease-related post-translational modification. Due to low stability, this transient modification currently escapes detection by established proteomic procedures. Moreover, little is known about the enzymes that catalyze aspartate phosphorylation. We here use specific nucleophilic traps that convert phosphoaspartate into stable modifications suitable for analytic detection. In addition, the complement of currently unknown phosphodonor proteins will be identified with customized tools. With these platforms we aim to functionally annotate sub-fractions of the uncharacterized proteome and utilize our tools for the identification of new drug targets by comparative analysis of healthy and diseased cells. Finally, we apply the camouflaged molecular design strategy in the synthesis of compound libraries to screen for candidate inhibitors against selected, disease-modulating targets. The previous record of my group in chemical proteomics provides a strong basis to achieve these challenging goals.
SYSTEM AND METHOD FOR INVISIBLE CHAT MEMBER REAL-TIME CHAT EVENT PROCESSING

A system and method for generating real-time notification based on events within a chat engine using an invisible chat member for readily capturing a plurality of chat events in at least one chat room and processing the chat events substantially on a real-time basis thereby creating an out-of-chat event.
Angularly adjustable toothbrush

An angularly adjustable toothbrush comprised of an elongated handle section and an elongated forward section with a brush array at its forward end. The after end of the forward section is provided with a transverse cylindrically rounded member with an axial orifice and flanked by a pair of concave shoulders facing rearwardly. A series of recesses spaced from each other is provided to circle part of the cylindrically rounded member. The handle section is bifurcated at its forward end to provide arms which embrace the cylindrically rounded member and are orificed in register with the member orifice to receive an axle pin to hold them together for rotation. The handle section has an axial bore extending from the bifurcation into the middle section of the handle and into which is disposed a slideable plunger biased forwardly by a spring toward the bifurcation so as to enter one of the recesses to lock the forward and handle sections in a particular angular configuration. The handle section is slotted into the bore to enable a central element to be secured to the plunger so that the plunger may be moved out of its biased position thereby enabling the angle of the forward section to be changed relative to the handle section.
Deep understanding and modelling of the hierarchical structure of prosody

The prime objective of the ProsoDeep project is to gain a deeper understanding of the language of prosody through the analysis of all the levels in the production hierarchy of prosody. In particular, it will exploit the benefits of the top-down and bottom-up approaches through their incorporation within a Deep Prosody Model (DPM). The DPM will facilitate the advancement of speech technologies that rely both on the synthesis of prosody, e.g. text-to-speech (TTS) systems, and its analysis, e.g. speech emotion recognition (SER). To reach this objective the project will draw on a variety of scientific fields, including signal processing, physiology of prosody production and biomechanics, linguistics, and machine learning, and will also be augmented with respiratory measurements.
ISOELASTIC PROSTHETIC FILET STITCH FABRIC

The invention concerns a filet stitch fabric based on a biocompatible polymer material monofilament, said material weave defining a plurality of cells with a substantially polygonal shape. The fabric is characterised in that the weave further provides the material with a substantially balanced multidirectional dynamometric behaviour whatever the stress direction. In particular, its weave is defined by a front lap and a rear lap of yarns knitted together according to a scheme 0-1/1-2/3-4/5-4/4-3/2-1 for the rear lap and 5-4/4-3/2-1/0-1/1-2/3-4 for the front lap.
Molecular engineering of push-pull chromophore for efficient bulk-heterojunction morphology in solution processed small molecule organic photovoltaics

The synthesis and characterization of new push-pull chromophores, bisDMFA-diTh-CA, bisDMFA-diTh-MMN, and bisDMFA-diTh-MIMN from 5′-(4-(bis(9,9-dimethyl-9H-fluoren-2-yl)aniline (bisDMFA) electron donating, dithiophene bridging, and various electron withdrawing moieties, cyanoacrylic acid (CA), methylene malononitrile (MMN), and methylene indenylidene malononitrile (MIMN), were demonstrated for efficient solution processed BHJ solar cells. The photophysical properties, the hole mobilities from the space charge limitation of current (SCLC) J-V characteristics, and surface morphologies of these materials/PCBM bulk-heterojunction films were also investigated. The best power conversion efficiency of 3.66% (±0.12) with Jsc = 11.82 mA/cm2, FF = 0.35, and Voc = 0.90 V was observed in the BHJ film fabricated with the bisDMFA-diTh-MMN/C71-PCBM composite with 3% 1-chloronaphthalene (CN), which is an efficiency ∼82% and ∼49% higher than before and after post-annealing without treatment of CN, respectively.
Media in the face of digitalisation: renewing capabilities and strategic thinking

The innovative research project tackles acute questions of organisational renewal capacity and change management in the radically changing media sector. The key question is how media organisations can renew their thinking, resource bases and capabilities in order to stay competitive while addressing the challenges of digitalisation. The research is carried out by conducting qualitative and quantitative analyses based on data collected in the German media industry. The media context offers an excellent example of a dynamic business environment brought about by technological convergence, rapidly changing media usage behaviour and increasing global competition. The theoretical framework is based on modern theories of strategic management research, especially in relation to the dynamic capability
view and the managerial cognition tradition. The combination of the two frameworks forms a unique multidisciplinary research approach that comprehensively helps European media organisations tackle organisational path dependencies and drivers of change. Understanding the factors that keep the media industry competitive is of great importance, because vital and diverse media is a key element of European democracy.
The project is a pioneering piece of research into media management and opens many new options for projects and international collaboration as well as applications in other industries facing digital transformation. The unique interdisciplinary approach and research setting combined with a highly important topic of European interest remarkably improves the senior researcher’s competencies through applying new theories and analysis methods. The project also extends her teaching skills through opportunities at the host institution related to strategic management and the media sector than at her home university. As a result the fellowship considerably widens her career opportunities, especially as the study will spur wider interest in both academia and practice.
Augmented Lagrangian based reconstruction of non-uniformly sub-Nyquist sampled MRI data

Abstract MRI has recently been identified as a promising application for compressed-sensing-like regularization because of its potential to speed up the acquisition while maintaining the image quality. Thereby non-uniform k-space trajectories, such as random or spiral trajectories, are becoming more and more important, because they are well suited to be used within the compressed-sensing (CS) acquisition framework. In this paper, we propose a new reconstruction technique for non-uniformly sub-Nyquist sampled k-space data. Several parts make up this technique, such as the non-uniform Fourier transform (NUFT), the discrete shearlet transform and a augmented Lagrangian based optimization algorithm. Because MRI images are real-valued, we introduce a new imaginary value suppressing prior, which attenuates imaginary components of MRI images during reconstruction, resulting in a better overall image quality. Further, a preconditioning based on the Voronoi cell size of each NUFT data point speeds up the conjugate gradient optimization used as part of the optimization algorithm. The resulting algorithm converges in a relatively small number of iterations and guarantees solutions that fully comply to the imposed constraints. The results show that the algorithm is applicable not only to sub-Nyquist sampled k-space reconstruction, but also to MR image fusion and/or resolution enhancement.
Osteodifferentiation of Human Preadipocytes Induced by Strontium Released from Hydrogels

In recent years, there has been an increasing interest in interactive application principles of biology and engineering for the development of valid biological systems for tissue regeneration, such as for the treatment of bone fractures or skeletal defects. The application of stem cells together with biomaterials releasing bioactive factors promotes the formation of bone tissue by inducing proliferation and/or cell differentiation. In this study, we used a clonal cell line from human adipose tissue-derived mesenchymal stem cells (hADSCs or preadipocytes), named PA2-E12, to evaluate the effects of strontium (Sr(2+)) released in the culture medium from an amidated carboxymethylcellulose (CMCA) hydrogel enriched with different Sr(2+) concentrations on osteodifferentiation. The osteoinductive effect was evaluated through both the expression of alkaline phophatase (ALP) activity and the hydroxyapatite (HA) production during 42 days of induction. Present data have shown that Sr(2+) released from CMCA promotes the osteodifferentiation induced by an osteogenic medium as shown by the increase of ALP activity at 7 and 14 days and of HA production at 14 days. In conclusion, the use of biomaterials able to release in situ osteoinductive agents, like Sr(2+), could represent a new strategy for future applications in bone tissue engineering.
Rome transformed: interdisciplinary analysis of political, military and religious regenerations of the city's forgotten quarter c1-c8 ce

This project revolutionises our understanding of Rome and its place in cultural change across the Mediterranean World by mapping political, military and religious changes to the Eastern Caelian from the first to eighth centuries.  The programme offers multiple gains for archaeologists, historians, topographers and geographers by documenting both the mundane and monumental elements of the city fabric in chronological, geographical and ideological relationship to one another. From the extravagant horti, the houses of elite families, through successive imperial palaces to the seat of papal governance the area’s architecture embodied changing expressions of political power. From the early military stations, through the grandeur of the barracks of the emperor’s horse guards, to the building and rebuilding of the Aurelian Walls, it reveals notions about the intersection of security and military power.  From the shrines of the early empire to the world’s first Cathedral, it attests successive religious regenerations. RomeTrans has three objectives: first, it determines the appearance of the buildings that drove these changes, producing academically robust visualisations, appropriately contextualised.  Second, it brings these elements together to model the five transformations that saw the Eastern Caelian reshaped to meet the needs of shifting political, military and religious ideas. Third, it provides a longer-term interdisciplinary perspective on the changing shape of this pivotal area than any previously attempted. All this requires a survey of unprecedented scale and sophistication, demanding a new methodology for complex urban areas capable of transforming research in historic towns worldwide. Integrating documentary sources, architectural analysis, investigation of 11 sub-surface excavated areas with the largest geo-radar and laser scanning surveys ever conducted in Rome, the project transforms our approach to the city and its relationship to the wider world.
The European Union as a Global Regulator?

1. The European Union as a global regulator? Context and comparison Alasdair R. Young 2. Liberalizing trade, not exporting rules: the limits to regulatory co-ordination in the EU's 'new generation' preferential trade agreements Alasdair R. Young 3. Coercion with kid gloves? The European Union's role in shaping a global regulatory framework for aviation emissions Vicki L. Birchfield 4. 'Man Overboard!' Was EU influence on the Maritime Labour Convention lost at sea? Robert Kissack 5. Putting the EU in its place: policy strategies and the global regulatory context Abraham L. Newman and Elliot Posner 6. Market power Europe: exploring a dynamic conceptual framework Chad Damro
BATTERY CELL HAVING A DETECTION INTERFACE

A system and method for a battery cell having an anode and a cathode, and a separator disposed between the anode and the cathode. A conductive layer disposed in the separator facilitates detection of dendrite growth from the anode into the separator, the detection correlative with a reduction in voltage between the anode and the conductive layer. A detection interface component coupled to the conductive layer is configured to facilitate routing of a signal from the conductive layer to a circuit external to the battery cell, the signal indicative of the detection. The battery cell may be a battery or part of a battery pack which may be utilized by an electronic device.
Development of nano-photocatalytic materials for indoor air purification and odour elimination

Pollutants released directly to the air are particularly harmful compared to soil and water pollutants. These pollutants severely affect people’s life quality and life expectancy. Indoor air purification at highly populated urban areas is technically challenging, because indoor air contaminants arise from both outside and indoor sources. The most hazardous indoor pollutants are volatile organic components, toxic inorganics, dust, bacteria, pollen and mold spores. Conventional ventilation brings outdoor air pollution inside the buildings and thus increases energy consumed for cleaning per room. Adapting new technological advances will help meeting requirements of a compact, reliable, and eco-friendly design. The main objective of this proposal is therefore to develop the next generation air purifiers where photocatalytic oxidation (PCO) technologies will allow elimination of a variety of hazardous indoor air pollutants, and bad odour caused by such pollutants, when illuminated by low-power light sources on-the-fly. The proposed project composes of four different phases: the state-of-the-art design of photocatalysts, selection of proper illuminating source, configuration of PCO system, and preparation of the first prototype. In this study, we will address the limited work performed within the field hitherto, such as the mechanism of catalyst deactivation, efficiencies of odour removal, generation of by-products, electron-hole recombination phenomenon, and the ways of providing anti-bacterial/good hygiene properties. We will carry out an in-depth investigation on optimization of PCO air purification system within an interdisciplinary work at Arçelik Central R&D.  After designing a viable configuration, we will focus on the production of a PCO air purifier prototype. In accordance with Arçelik Group’s policy and vision, our final goal is to ready the highly energy-efficient, low-noise, and reliable PCO air purifier prototype for the product launch in the global market.
TRANSFER OF CAPTURED DATA VIA WIRELESS DATALINK

Captured data is stored in a storage element. The captured data represents a record of at least one observed phenomenon. For example, the captured data may represent a still image or a video sequence. In response to a determination that a predetermined condition exists, the captured data is retrieved from the storage element and transmitted over a wireless datalink.
Acquisition of measuring instruments, innovation of equipment, software for creating protocols and downloading data.

Acquisition of a measuring instrument for measuring deviations and pulses of a specified meter – SM (tachograph), software for creating test reports and evaluating downloaded data from SM. SM data download machine. Computing technology as a whole. a.
BRAIDED REINFORCEMENT FOR AIRCRAFT FUSELAGE FRAMES AND METHOD OF PRODUCING THE SAME

A machine and method for applying braid by means of a braiding machine to a mandrel, where the mandrel has a shape that approximates a wheel but has an irregularly varying radius of curvature. The machine includes drive/positioning wheel assemblies that are used to continuously reposition a cross-section of the mandrel relative to the braiding machine such that a center point of cross-section of the mandrel is maintained to be coaxial with a braiding point of the braiding machine as the mandrel (18) is rotationally advanced by the drive/positioning wheel assemblies. Repositioning of the drive/positioning wheel assemblies is controlled by a computer numerical control (CNC) controller, based on information describing one or more radiuses of curvature for sections of the mandrel and a current position of the mandrel relative to the drive/positioning wheel assemblies.
Seasonal and Diurnal Dynamics of Subglacial Channels: Observations Beneath an Alpine Glacier

Abstract. Water flowing below glaciers exerts a major control on glacier basal sliding speeds. However, our knowledge on the physics of subglacial hydrology and its link with sliding is limited by lacking observations. Here we use a two-year long dataset made of on-ice measured seismic and in-situ measured glacier basal sliding speed records on the Glacier d’Argentière (French Alps) to investigate the physics of subglacial channels and its potential link with glacier basal sliding. Using dedicated theory and concomitant measurements of water discharge, we quantify temporal changes in channels hydraulic radius and hydraulic pressure gradient. At seasonal timescales we observe, for the first time, that hydraulic radius and hydraulic pressure gradient present a four-fold increase from spring to summer, followed by a comparable decrease towards autumn. At low discharge during the early and late melt season channels respond to changes in discharge mainly through changes in hydraulic radius, a regime that is consistent with predictions of channels behaving at equilibrium. In contrast, at high discharge and high short-term water-supply variability (summertime), channels undergo strong changes in hydraulic pressure gradient, a behavior that is consistent with channels being out-of-equilibrium. This out-of-equilibrium regime is further supported by observations at the diurnal scale, which demonstrate that channels pressurize in the morning and depressurize in the afternoon. During summer we also observe high and sustained basal sliding speeds, supporting that the widespread inefficient drainage system (cavities) is likely pressurized concomitantly with the channel-system. We propose that pressurized channels help sustain high pressure in cavities (and therefore high glacier sliding speeds) through an efficient hydraulic connection between the two systems. Using the two regimes herein observed in channels seasonal-dynamics as constraints for subglacial hydrology/ice dynamics models may allow to strengthen our knowledge on the physics of subglacial processes.
Perspective: Found in translation: Quantum chemical tools for grasping non-covalent interactions

Today's quantum chemistry methods are extremely powerful but rely upon complex quantities such as the massively multidimensional wavefunction or even the simpler electron density. Consequently, chemical insight and a chemist's intuition are often lost in this complexity leaving the results obtained difficult to rationalize. To handle this overabundance of information, computational chemists have developed tools and methodologies that assist in composing a more intuitive picture that permits better understanding of the intricacies of chemical behavior. In particular, the fundamental comprehension of phenomena governed by non-covalent interactions is not easily achieved in terms of either the total wavefunction or the total electron density, but can be accomplished using more informative quantities. This perspective provides an overview of these tools and methods that have been specifically developed or used to analyze, identify, quantify, and visualize non-covalent interactions. These include the quantitative energy decomposition analysis schemes and the more qualitative class of approaches such as the Non-covalent Interaction index, the Density Overlap Region Indicator, or quantum theory of atoms in molecules. Aside from the enhanced knowledge gained from these schemes, their strengths, limitations, as well as a roadmap for expanding their capabilities are emphasized.
EFEKTIVITAS PELAYANAN PUBLIK BIDANG KEPENDUDUKAN DAN CATATAN SIPIL PADA PEMERINTAH KABUPATEN KULON PROGO SETELAH BERLAKUNYA UNDANG-UNDANG NOMOR 25 TAHUN 2009 TENTANG PELAYANAN PUBLIK

The title of this legal research is the effectiveness of the Public Service
Division Civil Registration In Kulon Progo Regency After Applicability of Act No.
25 of 2009 on the Public Service. The purpose of this legal research is to
determine the effectiveness of the public service population and civil registration
in Kulon Progo regency government after the enactment of Law No. 25 of 2009 on
the Public Service. The type of this legal research was empirical legal research.
The data source used was primary data as main data despite of secondary data
used as supporting data. Results of the study of law is the public service in the
field of population and civil registration in Kulon Progo have led to the
effectiveness of public services, it is evidenced by the one-day service, SIAK
(Population Administration Information System) that facilitate and speed up the
administration of residence of the districts, the results survey of IKM (Community
Satisfaction Index), which is conducted every year by the department of
population and civil registration Kulon Progo with the results of the assessment of
society qualify as good, and SOP (Standard Operating Procedure) and SPP
(Standard Public Service) so as to realize the protection and certainty the law for
the public in the administration of public services in the field of population and
civil registration.