SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Le risque de maladie de Parkinson dans une population méditerranéenne de patients goutteux : étude cas-témoins

Des taux sanguins élevés d’acide urique, considéré comme un puissant antioxydant, ont été associés à un effet neuroprotecteur dans la maladie de Parkinson (MP). Cependant, la relation entre la goutte et la MP reste contradictoire. L’objectif est d’étudier si l’effet neuroprotecteur de l’acide urique est maintenu chez les patients goutteux au sein d’une large population urbaine méditerranéenne. Étude cas-témoins s’appuyant sur la base de données des dossiers médicaux électroniques des soins primaires du système de santé publique de Barcelone. Cette base de données contient les données anonymes de 1 520 934 patients. Tous les sujets âgés de plus de 40 ans, avec un nouveau diagnostic de MP ou une nouvelle prescription de médicaments dopaminergiques, ont été inclus (cas incidents). Chaque cas a été apparié sur l’âge et le sexe à quatre témoins sélectionnés de manière aléatoire, selon la méthode d’appariement en pourcentages. Les données rétrospectives des facteurs de risque de MP ont également été collectées pour chaque individu. Un modèle de régression logistique multivariée a été utilisé pour évaluer l’association entre la goutte et la MP, ajustée pour la présence d’autres facteurs de risques. Un nouveau diagnostic de MP a été posé chez 17 629 individus (taux de diagnostic incidents de 2,2 pour 1000 individus). Le modèle de régression logistique multivariée a montré pour la goutte : un ORa = 0,83 (0,76–0,91). Après stratification des individus par âge, l’ORa était de 0,99 (0,85–1,16) pour les sujets de moins de 75 ans et de 0,77 (0,70–0,86) pour ceux de 75 ans ou plus. La dyslipidémie, l’hypertension et le diabète ont été associés à un risque accru de MP. Le tabagisme a montré un rôle préventif dans l’apparition de la maladie. Notre étude, la première réalisée au sein d’une population méditerranéenne, a révélé un effet protecteur de la goutte contre le risque de MP chez les hommes et les femmes de plus de 75 ans.
BENZOTHIAZOLE DERIVATIVE AND ANTI-TUMOR USE THEREOF

The present invention relates to a benzothiazole derivative of formula 1 or a pharmaceutically acceptable salt thereof and a process for preparation thereof. The present invention also relates to a pharmaceutical composition comprising the compounds and the use of the compounds in the preparation of an anti-tumor medicament.
METHOD OF CREATING A SOLVENT-FREE POLYMERIC SILICON-CONTAINING QUATERNARY AMMONIUM ANTIMICROBIAL AGENT HAVING SUPERIOR SUSTAINED ANTIMICROBIAL PROPERTIES

An antimicrobial polymer is disclosed containing silicon-containing quaternary ammonium groups, the polymer including in its structure repeating units of Formula II: R<SUB>3</SUB>N<SUP>+</SUP>R°<SUB>n</SUB>SiX'<SUB>4-nY</SUB> <SUP>-</SUP>
MULTI-BATCH PROCESS FOR GENERATING PRECIPITATED CALCIUM CARBONATE

Multi-batch processes for forming precipitated calcium carbonate (PCC) using one or more reactors are described. A CO2 source and a calcium source are reacted in water partially or completely, and with or without additives to form calcium carbonate, which may be separated from the water as a precipitated calcium carbonate product having single or multiple modes, structures, and/or morphologies. In other embodiments, more than one reactor may be used to form PCC products having different properties, which are products are then combined. One or more reactors may have an output stream of PCC or excess reagents diverted to feed into one or more other reactors. The diverted output stream may be concentrated or modified by other means.
THERMOPLASTIC RESIN COMPOSITION, MANUFACTURING METHOD OF THERMOPLASTIC RESIN COMPOSITION, MOLDED PRODUCT AND MANUFACTURING METHOD OF MOLDED PRODUCT

A thermoplastic resin composition includes a graft copolymer (A) obtained by graft copolymerization of a monomer mixture (a) that includes at least an aromatic vinyl monomer (a1) and a (meth)acrylate monomer (a2), but does not practically contain a vinyl cyanide monomer (a3), in the presence of a rubbery polymer (r) having a refractive index of not lower than 1.510 and not higher than 1.520; and a vinyl copolymer (B). An acetone insoluble component (C) of the thermoplastic resin composition does not practically contain a vinyl cyanide monomer-derived unit. An acetone soluble component (D) of the thermoplastic resin composition contains the vinyl cyanide monomer-derived unit. The content of the vinyl cyanide monomer-derived unit is not lower than 2% by mass and not higher than 20% by mass relative to 100% by mass of the acetone soluble component (D).
Republication de : Calcification of the epiglottis: an unusual image

L’altération de l’odorat et/ou du goût est un symptôme majeur de l’infection par le SRAS-CoV-2, mais sa prévalence à l’échelle de la population est inconnue.À partir d’un questionnaire adressé à un échantillon représentatif de la population générale adulte française (≥ 18 ans) sur une période de 6 semaines pendant le premier confinement français (7 avril au 19 mai 2020), les nouveaux cas autodéclarés d’altération de l’odorat et/ou du goût ont été recueillis.Sur 29 660 participants, il y avait 2,18 % nouveaux cas d’altération de l’odorat et/ou du goût, et 2,11 % après standardisation directe sur la population française, représentant plus de 1 110 000 sujets en France. Par ailleurs, 0,5 % des participants ont rapporté un test de dépistage du SRAS-CoV-2 positif, parmi lesquels 47,4 % ont rapporté une nouvelle altération de l’odorat et/ou du goût. Les participants de sexe masculin, les plus jeunes ainsi que ceux présentant une pathologie chronique avaient une probabilité plus élevée de déclarer une nouvelle altération de l’odorat et/ou du goût.Cette étude fournit une estimation précise des nouveaux cas d’altération de l’odorat et/ou du goût dans la population générale à l’échelle nationale pendant la première vague de Covid-19.
Skin decontamination cream for radiological contaminants: Formulation development and evaluation

Increased use of the radioactive materials in the field of research, medical, nuclear power plant, and industry has increased the risk of accidental exposure. Intentional use of the radioisotopes by terrorist organizations could cause exposure/contamination of a number of the population. In view of the accidental contamination, there is a need to develop self-usable decontamination formulations that could be used immediately after contamination is suspected.Present work was planned to optimize and develop self-usable radiation decontamination cream formulation. Various pharmaceutical parameters were characterized. (99m)Tc-sodium pertechnetate was used as radiocontaminant. Static counts were recorded before and after decontamination using single photon emission computed tomography.Decontamination efficacy of the cream was found to be 42% ± 3% at 0-0.5 h after the exposure. Primary skin irritancy test was satisfactory as no erythema or edema was observed visually after 2 weeks of the formulation application.The decontamination studies proved the potential of EDTA to remove the radiological contaminants effectively.
Joint Optimization of Failure Management Costs, Electricity Costs, and Operator Revenue in Optical Core Networks

We focus on the problem of maximizing profitability in an optical core network by acting on the power states of optical line amplifiers (OLAs) and line cards (LCs) operating under varying traffic. Specifically, the profitability metric considered in this paper takes into account the electricity costs of OLAs and LCs, the failure management costs derived from the application of power states to the network devices, and the operator revenue. After proving that all terms of the considered profitability function are deeply inter-correlated, we formulate the optimization problem of maximizing the network profitability in an optical core network with multi-period traffic. By solving the proposed formulation on a realistic scenario, we show that it is possible to wisely trade between the considered costs and revenue, and achieve higher network profitability than in the case in which the single terms are considered in isolation, e.g., only electricity consumption or only failure management costs.
Bleaching compositions and method for bleaching substrates directly with air

A bleach composition and a method for bleaching stains is provided, the composition including a C7-C20 aromatic aldehyde and an imide, the latter being particularly N-hydroxyphthalimide. Air is employed as a source of oxygen which combines with the aldehyde to form the bleach active species. Peroxides, inorganic persalts and bleach precursors are unnecessary elements for the bleach systems of this invention.
Discover to Promote

"This project is part of the plan PACE ": The main objective of the project is to enhance, from a sustainable tourism perspective, the potential of the cultural heritage of the cross-border territory. The specific objectives are: 1) Networking diffuse heritage sites, thus creating cultural ecosystems by thematic dimension and territorial dimension; 2) unveil heritage, producing instruments and methods of dissemination, and making sites and content accessible; 3) mobilize and unite the territory's living forces, increasing participation in decision-making processes and the awareness/appropriation of sites. The expected results are the establishment of 4 thematic cross-border cultural ecosystems, and public awareness. Based on the heritage concerned by the other projects that make up the PITEM, the partners have identified the 4 themes (Prehistory, Historical Building, Resistance, Sacred and Profane) around which cross-border cultural ecosystems will be built.

The ALCOTRA 2014/2020 Program identifies, among the threats, the risk of loss of the cultural heritage, a finding which is even more worrying for the intangible heritage. Heritage is also threatened because of climate change, which amplifies the causes of deterioration of materials, and because of the lack of knowledge of local populations of the principles of restoration of traditional buildings. All this increases the risk of loss of the cultural concept, understood as an identity element / founder of a region, such as the Transboundary Region, which has gone through history and everywhere presents clear evidence of this cultural sharing. PITEM proposes to preserve the Alcotra space thanks to its cultural markers and their common evolution. Four projects based on a common chronological division will identify strategies for the conservation and exchange of good practices:
Tell, Save, Promote and Share. The actions will aim at the knowledge and safeguarding of tangible and intangible heritage, in order to provide users and the public with tools to understand the cultural value of the territory in line with environmental issues. The results of the projects will be part of a perspective of economic development, tourist attractiveness and boosting the cross-border territory.
Implementation of a Computing Device to Quality Service in Learning in Higher Education to Enhance Student’s Quality of Life

Our work is concerned with monitoring and periodic evaluation of students’ skills acquired during their university education. The objective of our work is to provide software tools for supporting and mentoring students in order to improve their quality of life. We suggest a computing device ISIFePortfolio which not only allows monitoring of learners, but also plays the role of an ePortfolio (electronic portfolio) skills, and a social networking combined systems. This tool includes a broad range of collaborative working solutions and the ePortfolio is considered an extension of the paper records of a student as an individual digital space available on the Internet in such a secure and personalized way, collecting personal resources, experiences, studies, acquired skills, relationships with trainers, working groups, classmates and that will be saved throughout the training course. Based on Mahara technology, ISIFePortfolio is an application implemented by ORDIPU team at the University Hassan II Mohammedia Casablanca. It has been integrated into the platform of distance education Education Master ISIF for the master Engineering Information Systems and Training. Keyword: computing device, ePortfolio, skills, digital monitoring of the learner, evaluation, quality of life.
Ultrasensitive plasmonic devices for early cancer diagnosis

Cancer biomarkers circulating in body fluids have been shown to reflect the pathological process and for this reason can be used for cancer diagnosis, prognosis and choice for therapeutic interventions. It is proven that their detection is a key to new minimal-invasive detection approaches. However, barriers to wide spread use of similar approaches are lack of test sensitivity, specificity and limited availability of low cost detection platforms. This project is focused at developing a compact plasmonic-based device with integrated microfluidic circuit and functionalized nanostructures for the detection of DNA, microRNA and tumor autoantibodies cancer biomarkers. 

The aim is to detect cancer biomarkers circulating in blood with improvement in sensitivity of factor up to 1000, reduction in cost of platform of factor ranging from 2 to 4 compared to today’s available techniques and analysis time less than 60 minutes. The proposed detection approache will provide ultrasensitive detection of biomolecular systems with no need for complex sample chemical modifications thus allowing direct and simple assays to be performed. Within the project a bimodal industrial prototype will be developed integrating novel surface plasmon resonance imaging and plasmon-enhanced fluorescence sensing technologies, respectively. Automated fabrication processes suitable for low cost mass production will be developed and applied to produce disposable integrated chips. Prototype will be specifically fabricated for early diagnosis and prognosis  of colorectal cancer. The team includes partners holding cross-disciplinary competencies needed to achieve the proposed results, including two of the first five plasmon resonance groups in the world, the inventor of surface plasmon microscopy – also known as surface plasmon resonance imaging- and plasmon-enhanced fluorescence spectroscopy, and full European value chain including disposable chip and readout platforms design, development and manufacturing.
NASA’s Next Generation Surface Deformation and Change Observing System Architecture

The United States National Aeronautics and Space Administration (NASA) has initiated a five-year study of a Surface Deformation and Change Observing System Architecture. The goal of the study is to define an observing system that would meet the recommendations of the 2017 US National Academy of Sciences, Engineering, and Medicine Decadal Survey [1] for developing an affordable synthetic aperture radar-based system or systems that can address fundamental scientific questions about the nature of hazards, disasters, landscape change, and serve applications communities as well. The study is to consider the existing international constellation of SAR systems, both civil and commercial, as well as new technologies that could be employed to address scientific and applications objectives and to improve affordability. The study will be conducted in four phases: 1) expanding the architectural trade space; 2) assessing the science and applications value of each identified architecture; 3) down selecting to three final candidates and performing detailed assessments; 4) final reporting and preparation for mission formulation. The first phase is approximately 2 years in duration, and will concentrate on the scope of research and application areas to be addressed, defining the possible architectures to consider, and beginning the assessment of their performance. The study team comprises five NASA centers. Broad participation from the research, applications, technology, and commercial sectors is planned.
Advanced simulation techniques for gaseous detectors: application on spherical proportional counters

The “Geant4 and GARfield integration” (GaGARin) project will deliver a powerful and fully validated simulation framework for gaseous detectors. The strengths of the established GEANT4 and GARFIELD++ toolkits will be combined in a flexible framework and made freely available, for the first time, in the public domain to researchers using gaseous detectors for fundamental research and applications. GaGARin will be optimised with advanced compu- tational techniques, targeting growing technologies such as GPUs, and will be exhaustively validated with dedicated measurements from a range of state-of-the-art gaseous detectors, including micro-pattern gaseous detectors (MPGDs) and spherical proportional counters (SPCs). A variety of detector configurations and operating conditions will be explored, to maximally validate the implemented physics modelling. GaGARin will immediately allow for new insights into physics experiments, such as direct dark matter (DM) and neutrinoless double-beta decay searches (0νββ), and design and optimisation of novel detectors. Furthermore, it will enable the implementation of advanced ana- lysis techniques, maximising experimental sensitivity. In industrial applications, where use of gaseous detectors is widespread, GaGARin will open up new possibilities, for example in neutron spectroscopy with SPCs.
A self-report study that gauges perceived and induced emotion with music

This paper discusses a particular study that gauges emotion with respect to music by means of an online self-report survey. This is part of the ongoing construct of an intelligent mobile music player application that will adjudicate one's activity, environmental context, and physiological state. The study was structured so as to acquire emotional information by giving each participant a discrete affect word including ‘happy’, ‘excited’, ‘angry’, ‘afraid’, ‘miserable’, ‘sad’, ‘tired’, and ‘relaxed’. Each affect word that was selected for a given song was corroborated by a degree of intensity using 5-point scale. The fundamental objective of this study was to measure as to how each song could be described emotionally, and how each song made them feel emotionally. Pearson's Chi-Squared concluded that 95% of the ratings for both ‘described’ and ‘induced’ emotions were statistically significant. The corresponding results were scaled to the proposed circular-based emotional model based on Russell's Circumplex model of emotion, by converting both the emotional ratings to polar coordinates. Further analysis of the data subsequently showed that the affect words that represent music could be given some granularity around the perimeter of the circle by expanding upon particular properties of Russell's circular ordering of affect words. Lastly, this paper concludes with a Section that outlines the future work for this research.
Patient-centered outcomes in breast cancer: Description of EQ-5D-5L and EORTC-QLQ-BR23 measurements in real world data.

e18621 Background: Major improvements in breast cancer (BC) treatments have led to a significant increase in overall survival. Quality of life (QoL) is one of the main goals of cancer treatment and patient-centered outcomes are measured in almost all randomized clinical trials, but real-world data are lacking in the literature. Methods: This is a prospective, multicenter, observational study of female BC patients, without prior systemic treatment, treated between 2012 and 2019 in private healthcare in Sao Paulo and Rio de Janeiro, Brazil. QoL was assessed by EQ-5D-5L and EORTC-QLQ-BR23 at baseline, 3, 6, 9 and 12 months. All measures were presented as means and analyzed according to staging and subtypes using the Kruskal-Wallis test. A linear mixed model was used to assess the changes in the mean scores over time. Results were reported as increments relative to the baseline category, using 95% confidence intervals and p values. Results: A total of 1,372 female BC patients were evaluated, with a median age at diagnosis of 53.8 years. Stage 0, I, II, III and IV were diagnosed in 11%, 36%, 31%, 16% and 3% of the patients, respectively. Among the five dimensions of the EQ-5D-5L questionnaire, at baseline, the main reported problem was anxiety/depression, in which 37.1% and 19.5% reported slight and moderate symptoms, respectively. In the EQ VAS (visual analogue scale), patients stage III and IV had significantly lower score at baseline, 77.1 and 69.7 respectively, compared to stage I and II, 79.5 and 79.2 respectively (p = 0.016). Despite the high symptom burden at baseline, patients with metastatic BC had the most significant improvement after treatment, with 8.85 points difference at 12 months in absolute values from baseline (p = 0.005). Among EORTC-QLQ-BR23 measures, the baseline scores were similar between all stages, except for more “breast symptoms” in stage III patients, and more “systemic therapy” symptoms and better “sexual functioning” for stage IV patients, compared with early stages (p &lt; 0.005). When we assess the impact of surgical treatment over time, patients undergoing lumpectomy had a better perception of “body image”, and axillary dissection led to more “arm symptoms” after 12 months. Similarly, radiotherapy enhanced “breast symptoms” and patients treated with chemotherapy had significantly more “systemic therapy” side effects compared with other treatments. Conclusions: In our population, patients with stage III/IV BC had worse baseline health perception, but those with metastatic disease had the greatest improvement over time, due to the benefit of systemic treatment. Patients undergoing chemotherapy, mastectomy, and radiation therapy reported worse QoL and long-term side effects. Early diagnosis and access to treatments with fewer side effects should be our future goals.
Process Systems Engineering of High-low Temperature Fischer-Tropsch Synthesis Integration in Olefin Production

Abstract A novel system combing high- and low-temperature Fischer-Tropsch synthesis (HTFT and LTFT) in olefin production is proposed. Utilizing syngas from coal gasification as the feed gas, the combined system integrates the advantages of HTFT and LTFT and results in an increased range of products, namely α-olefins (mainly C4, C6, and C8), synthetic lubricant, gasoline, diesel, naphtha, greatly enhancing the system’s market adaptability. The system avoids the risk of product market fluctuation, and especially realizes the objective of diversifying production and maximizing economic benefit. Ethylene oligomerization process is innovatively proposed to increase the α-olefins production. A techno-economic analysis was performed on the above system using Aspen Plus software. Results indicated that the income of α-olefins accounts for at least 20% of the total income of the system and this percentage increases with increasing contribution share of HTFT to the combined synthesis system. From the viewpoint of economic perspective, the optimal ratio of HTFT to LTFT for the HTFT - LTFT combined system with ethylene oligomerization scheme is 3:2. The project is expected to have a net present value of 11.45 billion USD, and internal rate of return of 28.31% under the current economic consumption, which shows excellent economic profits and demonstrates that the combined system presents the remarkable ability to resist market risks compared to traditional stand-alone HTFT or LTFT process under a low oil price scenario.