SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Ruthenium (II) Complexes Interact with Human Serum Albumin and Induce Apoptosis of Tumor Cells

The interaction of ruthenium (II) complex [Ru(bpy)2(mal)](2+) (RBM) and [Ru(phen)2(mal)](2+) (RPM) (bpy = 2, 2-bipyridine, phen = 1,10-phenanthroline, mal = malonyl carboxylate) with human serum albumin (HSA) has been investigated by using fluorescence, UV absorption and circular dichroism (CD) spectroscopy approaches. A strong fluorescence quenching reaction of complexes to HSA was observed and the quenching mechanism was suggested as static quenching according to the Stern-Volmer (S-V) equation. The number of binding sites n and observed binding constant Kb was measured by fluorescence quenching method. The thermodynamic parameters ΔH, ΔS, and ΔG at different temperatures were calculated and the results indicate the binding reaction is mainly entropy-driven and Vander Waals force played a major role in the reaction. The result of CD showed that the secondary structure of HSA molecules was changed in the presence of the ruthenium (II) complexes. Furthermore, the cell viability of ruthenium (II) complexes was evaluated by MTT and complex RPM has shown significant higher anticancer potency than RBM against all the cell lines screened. RPM showed a significant antitumor activity through induction of apoptosis in A549 cells.
Long-range correlations of polarization and number densities in dilute electrolytes

In dilute electrolytes, we calculate the pair correlation functions among the solvent polarization p, the solvent density n1, the cation density n2, and the anion density n3. We set up a simple Ginzburg-Landau free energy for these variables, so our results are valid at distances longer than the molecular size σ. In particular, we reproduce the Hoye-Stell result for the polarization correlation ⟨pα(r)pβ(0)⟩ (α, β = x, y, z) [J. S. Hoye and G. Stell, J. Chem. Phys. 68, 4145 (1978)], which is proportional to the second derivative ∂2(e-κr/r)/∂xα∂xβ for r ≫ σ with κ being the Debye wave number. We also show that size asymmetry between the cations and the anions gives rise to similar long-range correlations in ⟨pα(r)δn1(0)⟩ and ⟨δni(r)δn1(0)⟩ (i = 1, 2, 3). Moreover, we calculate the polarization time-correlation function. As a unique feature in dynamics, the longitudinal polarization fluctuations (∝∇ · p) consist of rapidly decaying and slowly decaying components, where the latter relax with the charge density ρ. As a result, the long-range part of the equal-time polarization correlation changes into a different long-ranged and long-lived form after the shorter polarization relaxation.
Security controversies: exploring the governance of knowledge, innovation and techno-scientific risks

The EU is one of the key proponents of knowledge-based economy, i.e. an economic system based on research, development, and knowledge production. However, techno-scientific progress may bring not only benefits and well-being to the society, but also undesired side-effects and new dilemmas. Apart from social, ethical, or environmental controversies that scientific research opens, innovation is now increasingly linked with security controversies, characterized by the concerns over a potential misuse of science for hostile purposes. Yet with the ever-accelerating speed of scientific inquiry and the rise of interdisciplinary and international connections, it becomes impossible to clearly define and police “dangerous” research that could be exploited by terrorists and criminals. To balance the demands for scientific openness with national security interests, new techniques of governance are introduced in science, which integrate the existing principles of scientific responsibility with security practices restricting the mobility of scientific knowledge.
This project aims to build a unique body of interdisciplinary expertise to study security controversies in the governance of research and innovation. It will link researchers from security studies and science and technology studies with leading biotechnological stakeholders in Austria and practitioners of Responsible Research and Innovation (RRI) involved in ethics review of EU research projects. Specifically, the project will, first, situate the current security controversies historically and theoretically, second, map the techniques of knowledge governance in health-data governance and RRI, and third, explore what competences and skills are required in the assessment of security risks of scientific knowledge mobility in the two empirical areas. In sum, the project will set out a research agenda to study how our societies design, implement, and regulate sensitive and potentially dual-use research and innovation.
SUSPENSIÓN PARA ADMINISTRACIÓN ORAL QUE COMPRENDE TOLVAPTÁN AMORFO, Y A UN MÉTODO PARA PRODUCIRLA

Una suspensión para administración oral que comprende partículas que contienen tolvaptán amorfo que pueden inhibir o retardar la cristalización del tolvaptán amorfo con el tiempo en la suspensión, y mantener en forma estable una alta solubilidad del tolvaptán y una excelente absorbabilidad del tolvaptán en el tracto gastrointestinal, y una formulación sólida para administración oral que se puede suspender para preparar la suspensión para administración oral al momento de uso. Se refiere a una suspensión para administración oral, en particular, un jarabe, que comprende (a) partículas que contienen tolvaptán amorfo, (b) hidroxipropilmetilcelulosa (HPMC), y (c) un solvente, donde la cantidad de HPMC (b) oscila entre el 0,1 y el 25% en peso en base al peso total de la suspensión para administración oral. Reivindicación 9: La suspensión para administración oral de acuerdo con cualquiera de las reivindicaciones 1 a 8, que también comprende (d) un agente de suspensión y/o (e) un edulcorante. Reivindicación 10: La suspensión para administración oral de acuerdo con la reivindicación 9, caracterizada porque el agente de suspensión (d) es al menos un miembro seleccionado entre el grupo compuesto por goma xántica, goma gellan, carragenano, polímeros de carboxivinilo y carboximetilcelulosa de sodio.
SPATIAL-SPECTRAL FINGERPRINT SPOOF DETECTION

Methods and apparatus are provided of deriving a discrimination feature set for use in identifying biometric spoofs. True skin sites are illuminated under distinct optical conditions and light reflected from each of the true skin sites is received. True-skin feature values are derived to characterize the true skin sites. Biometric spoofs is similarly illuminated under the distinct optical conditions and light reflected from the spoofs is received. Spoof feature values are derived to characterize the biometric spoofs. The derived true-skin feature values are compared with the derived spoof feature values to select a subset of the features to define the discrimination feature set.
The good, the bad ... and 'Rango': A chameleonic quest in the wild west

'Rango' (Gore Verbinski, 2011) is the quirky tale of an isolated chameleon (Johnny Depp) who suddenly finds himself ejected from his ordinary existence and cast into the frame of the American frontier. It is through the conventions of the western that fundamental questions of identity and role-play are answered. The western, with its concern for violence, conflict and the ideology of 'manifest destiny', is one of the film genres most powerfully driven by narrative. But 'Rango's' postmodernist play with genre, narrative and the protean nature of the self engages in powerful ways with the history of film and the transformative importance of stories in our search for identity.
Maximizing coupling-efficiency of high-power diode lasers utilizing hybrid assembly technology

In this paper, we present hybrid assembly technology to maximize coupling efficiency for spatially combined laser systems. High quality components, such as center-turned focusing units, as well as suitable assembly strategies are necessary to obtain highest possible output ratios. Alignment strategies are challenging tasks due to their complexity and sensitivity. Especially in low-volume production fully automated systems are economically at a disadvantage, as operator experience is often expensive. However reproducibility and quality of automatically assembled systems can be superior. Therefore automated and manual assembly techniques are combined to obtain high coupling efficiency while preserving maximum flexibility. The paper will describe necessary equipment and software to enable hybrid assembly processes. Micromanipulator technology with high step-resolution and six degrees of freedom provide a large number of possible evaluation points. Automated algorithms are necess ary to speed-up data gathering and alignment to efficiently utilize available granularity for manual assembly processes. Furthermore, an engineering environment is presented to enable rapid prototyping of automation tasks with simultaneous data ev aluation. Integration with simulation environments, e.g. Zemax, allows the verification of assembly strategies in advance. Data driven decision making ensures constant high quality, documents the assembly process and is a basis for further improvement. The hybrid assembly technology has been applied on several applications for efficiencies above 80% and will be discussed in this paper. High level coupling efficiency has been achieved with minimized assembly as a result of semi-automated alignment. This paper will focus on hybrid automation for optimizing and attaching turning mirrors and collimation lenses.
The Gene Therapy Resource Program: A Decade of Dedication to Translational Research by the National Heart, Lung, and Blood Institute

Over a 10-year period, the Gene Therapy Resource Program (GTRP) of the National Heart Lung and Blood Institute has provided a set of core services to investigators to facilitate the clinical translation of gene therapy. These services have included a preclinical (research-grade) vector production core; current Good Manufacturing Practice clinical-grade vector cores for recombinant adeno-associated virus and lentivirus vectors; a pharmacology and toxicology core; and a coordinating center to manage program logistics and to provide regulatory and financial support to early-phase clinical trials. In addition, the GTRP has utilized a Steering Committee and a Scientific Review Board to guide overall progress and effectiveness and to evaluate individual proposals. These resources have been deployed to assist 82 investigators with 172 approved service proposals. These efforts have assisted in clinical trial implementation across a wide range of genetic, cardiac, pulmonary, and blood diseases. Program outcomes and potential future directions of the program are discussed.
Holistic digital-to-physical prototyping and production pilot for microfluidic mems

The project aims at a holistic new design strategy, coordinated pilot lines and business model for the prototyping, fabrication and commercialization of polymer-based microfluidic systems.  It stems from the recognition that a microfluidic chip is a key part of a microfluidic MEMS, but only a part. Many limitations to fast prototyping, industrialization and ultimate performances lie not in the chip itself, but in the world-to-chip connections and integration of multiple external components. We shall address in a single strategy the streamlined construction of whole microfluidic systems, starting from existing pilot lines in injection moulding, 3D printing and instrument construction. This will specific innovations. First, the resolution of 3D printing will be increased by a factor at least 10, down to  1~3µm, with a throughput 10 to 100x higher than that of current high resolution 3D printing machines, to support the flexible production of chips with complex 3D architectures. New soft, bio, environment-friendly and/or active materials will be integrated in the production chain using a technology patented by the partners. Large-scale markets requiring mass production at the lowest cost  will be addressed by a fully integrated pilot line, streamlining injection moulding of raw chips, reagents and components integration, sealing  and quality control.  Inter-compatibility between 3D printing and injection moulding, regarding architectures  and materials, will be developed to accelerate the prototype to product value chain.  After development and upscaling, the technology will be demonstrated and qualified in operational environment  by end-users with lab-on-chip  applications in health (cancer diagnosis, organ-on chip) and environment (water control). Partners jointly have the production lines onto which the project’s innovation will be readily integrated, helping  microfluidics to become a major component of the 4th industrial revolution.
Plasma total antioxidant capacity (TAC) in obese Malaysian subjects.

There is a pressing need to better understand the complex biochemical pathways that lead to the pathogenesis of obesity. Increased oxidative stress and decreased antioxidant capacity have been identified to be associated with obesity. Therefore, the objectives of this study were to determine the plasma total antioxidant capacity (TAC) levels of Malaysian subjects and to evaluate its potential association with obesity and related anthropometric measurements.Plasma TAC of 362 multi-ethnic Malaysian subjects from the Kampar Health Clinic (138 males, 224 females; 124 ethnic Malays, 152 Chinese, 86 Indians; 192 non-obese, 170 obese) was measured using Trolox equivalent antioxidant capacity (TEAC) 96-well plate assay.Plasma TAC was significantly lower in obese subjects (M +/- SE = 292 +/- 10.4 micromol/L) compared to non-obese subjects (397 +/- 8.58 micromol/L), whereas it was significantly higher in males and those in the 21-30 age group. Those with salty food preference and practising a strict vegetarian diet also had significantly higher plasma TAC. However, no association was found for other dietary habits (coffee intake) and lifestyle factors (physical activity, smoking). Plasma TAC was also significantly negatively correlated with diastolic blood pressure, waist and hip circumferences, weight, body mass index, total body fat, % subcutaneous fat, visceral fat level, resting metabolism and % skeletal muscle.Plasma TAC was found to be associated with obesity, strict vegetarian practice, salty food preference and all obesity anthropometric indicators, except systolic blood pressure and pulse rate. Obese people have decreased plasma TAC indicating a compromised systemic antioxidant defence and increased oxidative stress.
Efficacy and safety of leuprorelin acetate 6-month depot in prostate cancer patients: a Phase III, randomized, open-label, parallel-group, comparative study in Japan

Leuprorelin acetate (TAP-144-SR) is commonly used worldwide in prostate cancer patients. This study was conducted to assess the non-inferiority of a 6-month depot formulation of TAP-144-SR (TAP-144-SR [6M]) 22.5 mg to a 3-month depot formulation of TAP-144-SR (TAP-144-SR [3M]) 11.25 mg in prostate cancer patients in Japan.This was a 48-week Phase III, open-label, parallel-group comparative study. TAP-144-SR (6M) 22.5 mg (6M group) and TAP-144-SR (3M) 11.25 mg (3M group) were administered to 81 and 79 subjects, respectively. The primary endpoint was the rate of serum testosterone suppression to the castrate level (≤100 ng/dl).Serum testosterone of all subjects excluding one subject in the 3M group was suppressed to the castrate level throughout 48 weeks. The estimated between-group difference (6M group - 3M group) in suppression rate was 1.3% (95% confidence interval: -3.4, 6.8), and its lower confidence interval was more than -10% of the pre-determined allowable limit value to judge the non-inferiority. The prostate-specific antigen concentrations were stable throughout the study in both groups. Progressive disease in the best overall response based on the Response Evaluation Criteria In Solid Tumors was 0.0% for the 6M group and 2.6% for the 3M group. Adverse events occurred in 92.6% in the 6M group and 89.9% in the 3M group. Adverse events leading to discontinuation were reported in 2.5% in the 6M group and 3.8% in the 3M group.TAP-144-SR (6M) was not inferior to TAP-144-SR (3M) for the suppressive effect on serum testosterone level. TAP-144-SR (6M) was also as well tolerated as TAP-144-SR (3M).
The Making of Holy Russia: The Orthodox Church and Russian Nationalism Before the Revolution

This book is a critical study of the interaction between the Russian Church and society in the late 19th and early 20th century. While other studies exist that draw attention to the voices in the Church typified as liberal in the years leading up to the Revolution, this work introduces a wide range of conservative opinion that equally strove for spiritual renewal and the spread of the Gospel. Grounded in original research conducted in the newly accessible libraries and archives of post-Soviet Russia, this study is intended to reveal the wider relevance of its topic to an ongoing discussion of the relationship between national or ethnic identities on the one hand, and the self-understanding of Orthodox Christianity as a universal and transformative faith on the other.
Permanent cross-border observatory on the biodiversity situation in the Karst area

Across the Italian-Slovenian border, the Karst area is a meeting point for species from Central Europe, the Alps, Italy, the Mediterranean and the Balkans, with a high degree of biodiversity. This situation is eloquently witnessed by the number and extension, both in Italy and in Slovenia, of the areas covered by the Habitat and Birds directives (Natura 2000 Network), and by regional and national laws on the conservation of nature. The current project aims at setting up an Italian-Slovenian technical-scientific working party and a Centre for the assessment of the environmental situation in the Karst area; the monitoring of overall biodiversity is envisaged, together with the study of some habitats and vegetal and animal communities. In a later stage, these aspects are connected with human presence and activities. The Centre has the task of collecting, in a common database, all the data gathered during the research already carried out or still in progress in the Karst area, paying particular attention to the distribution of animal and vegetal habitat and species. A permanent monitoring system is used to assess the situation: some animal and vegetal habitats (with their related communities) are employed as indicators (or reference systems). The centre collects also the data concerning the projects in progress - both those of a scientific nature and those aimed at the conservation of nature and the sustainable use of the territory. The exchange of experiences and knowledge connected to these projects is fostered. Finally, an international university course is promoted, focusing on the issues of sustainable development and biodiversity conservation, to encourage the exchange of teachers and students.
An e-infrastructure for software, training and consultancy in simulation and modelling

E-CAM will create, develop and sustain a European infrastructure for computational science applied to simulation and modelling of materials and of biological processes of industrial and societal importance. Building on the already significant network of 15 CECAM centres across Europe and the PRACE initiative, it will create a distributed, sustainable centre for simulation and modelling at and across the atomic, molecular and continuum scales. 

The ambitious goals of E-CAM will be achieved through three complementary instruments: 

1. development, testing, maintenance, and dissemination of robust software modules targeted at end-user needs;
2. advanced training of current and future academic and industrial researchers able to exploit these capabilities; 
3. multidisciplinary, coordinated, top-level applied consultancy to industrial end-users (both large multinationals and SMEs). 

The creation and development of this infrastructure will also impact academic research by creating a training opportunity for over 300 researchers in computational science as applied to their domain expertise. 

It will also provide a structure for the optimisation and long-term maintenance of important codes and provide a route for their exploitation. Based on the requests from its industrial end-users, E-CAM will deliver new software in a broad field by creating over 200 new, robust software modules. The modules will be written to run with maximum efficiency on hardware with different architectures, available at four PRACE centres and at the Hartree Centre for HPC in Industry. The modules will form the core of a software library (the E-CAM library) that will continue to grow and provide benefit well beyond the funding period of the project. 

E-CAM has a 66 month duration, involves 48 staff years of effort, has a total budget of €5,836,897 and is requesting funding from the EC of €4,836,897, commensurate with achieving its ambitious goals.
Adattamento alla COVID-19

Il progetto mira ad adattare l'azienda al fine di ridurre al minimo i rischi di contagio ed essere in grado di lavorare in sicurezza, minimizzando i rischi di contagio da COVID. Esso mira ad attuare misure rafforzate di igiene, circolazione, protezione dei dipendenti, dei fornitori e dei clienti.
Maternal influences on thiamine status of walleye Sander vitreus ova

Concentrations of the various forms of thiamine (vitamin B(1) ) were determined in walleye Sander vitreus ova from three central North American lakes. Total thiamine concentrations in ova from Lake Winnipeg S. vitreus were approximately three times greater (mean 12 nmol g(-1) ) than in those from Lakes Erie or Ontario. The percentage of thiamine in the active form (thiamine pyrophosphate, TPP) was highest in Lake Ontario ova (mean 88%) and lowest in those from Lake Winnipeg (mean 70%). Neither ova total thiamine concentration nor per cent ova thiamine as TPP showed any consistent relationships with maternal age, size, morphometric condition, somatic lipid concentrations or liver lipid concentrations. Ova total thiamine concentration, however, was negatively related to ovum size in some populations, as well as among populations, and was positively related to liver total thiamine concentration. Maternal transfer of thiamine to ova appears to be independent of female ontogenetic or conditional state in S. vitreus.
Automated program analysis for advanced web applications

Web applications that execute in the user's web browser constitute a substantial part of modern software. JavaScript is the main programming language of the web, although alternatives are emerging, in particular, TypeScript and Dart. Despite the advances in design of languages and libraries, it is difficult to prevent errors when programming such web applications. Although the basic principles of software verification have been known for decades and researchers have developed an abundance of techniques for formal reasoning about programs, modern software has lots of errors, as everyday users can testify. 

The PAW project will create novel automated program analysis algorithms for preventing errors and improving performance of advanced web applications. The project hypothesis is that a scientific breakthrough is within reach, due to recent results in static and dynamic program analysis for JavaScript. The central idea is to combine static and dynamic analysis in new ways. In addition, the project will make program analysis algorithms and infrastructure available in a form that embraces reusability.