SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Sea ice across dansgaard-oeschger events in greenland

The Last Glacial climate of the Northern Hemisphere was punctuated by abrupt millennial scale changes called Dansgaard-Oeschger (DO) events, clearly recorded by Greenland ice core temperature proxies. The underlying mechanism responsible for the recurring cycles of ~10°C rapid increase, followed by gradual cooling, remains uncertain. Many studies suggest that large changes in sea ice extent played a major role in their causation.  Sea ice is closely linked to climate; changes in sea ice extent feedback positively on Arctic temperature—a phenomenon of great relevance to the future of Arctic sea ice in our changing climate. This project combines Greenland ice core chemistry records with atmospheric chemistry transport modeling in order to constrain Arctic sea ice variability across DO events.  Records of sea salt (Na+), and methane sulphonic acid (MSA), from four ice cores will be analysed for spatial and temporal variability across DO events. The controls on marine aerosol deposition over the Greenland Ice Sheet will be investigated using a atmospheric chemistry transport model, Cambridge p-TOMCAT, which has been successfully deployed for the Antarctic. The relative influence of sea ice and other factors e.g., meteorology, on ice core chemistry variability will be assessed using sensitivity tests that will also provide an indication of the gross sea ice changes in required to reproduce the significant sea salt changes recorded in ice cores. Furthermore, an atmospheric chemistry transport model, that can be interfaced with fully coupled ocean-atmosphere climate model output, will be optimised according to our findings. This model will be run with palaeoclimatic boundary conditions to obtain scenarios of sea ice change consistent with the ice core chemistry data. Separate tests will constrain the magnitude of sea ice retreat at the onset of DO events and the temporal evolution of sea ice conditions as climate cools from warm interstadial to cool stadial conditions.
Hox5 Genes Regulate the Wnt2/2b-Bmp4-Signaling Axis during Lung Development

Hox genes are required for proper anteroposterior axial patterning and the development of several organ systems. Here, we show that all three Hox5 paralogous genes play redundant roles in the developing lung. Hoxa5;Hoxb5;Hoxc5 triple-mutant embryos develop severely hypoplastic lungs with reduced branching and proximal-distal patterning defects. Hox5 genes are exclusively expressed in the lung mesoderm; however, defects are observed in both lung mesenchyme and endodermally derived epithelium, demonstrating that Hox5 genes act to regulate mesodermal-epithelial crosstalk during development. We show that Hox5 loss of function leads to loss of Wnt2/2b expression in the distal lung mesenchyme and the downregulation of previously identified downstream targets of Wnt2/2b signaling, including Lef1, Axin2, and Bmp4. Wnt2/2b-enriched media rescue proper Sox2/Sox9 patterning and restore Bmp4 expression in Hox5 triple-mutant lung explants. Taken together, these data show that Hox5 genes are key upstream mesenchymal regulators of the Wnt2/2b-Bmp4-signaling axis critical for proper lung patterning.
Business support network – east anatolia

This project will offer quality innovation-support services in order to enhance and strengthen the technological and innovation capacity of
selected SMEs in the region. The expected result of the services will significantly increase the technological and innovation capacity of the
client SMEs. “Enhancing and strengthening the Research and Innovation capacity of potential SMEs in the region covered by the participant
partners” will be the main objective of this work programme.
The approach of the project will be to accompany, guide and support the SMEs along their journey to Horizon 2020, ensuring best use and
successful completion of the H2020 SME Instrument projects. A main goal will be to establish effective Innovation Management Systems in
SMEs in response to their needs.
The project services will be:
• To increase the R&D and innovation management capacities of SMEs
• To introduce them to the SME Instrument
• To maintain awareness of intellectual property rights.
To achieve the above mentioned services the Partners will ensure of the level of readiness of the client SME at each step of the serviceprocess.
METHOD FOR CUTTING A PATCH TO BE APPLIED ONTO A CURVED SUBSTRATE

The invention relates to a method for cutting a patch to be applied onto a curved substrate (20) that includes the preliminary calculation of curvilinear lengths (I1, I2, I3,...) on the substrate between a reference point (O) and a peripheral edge (B) of said substrate. The calculated lengths are applied to a planar film for making the patch, and then the patch is cut by connecting the ends (C1, C2, C3,...) of the applied lengths. The patch then precisely coincides with the edge of the substrate. Such a method is particularly useful for applying a functional film onto a spectacle lens, as a trimming of the lens after the film is assembled with the lens would degrade said film.
Single‐cell transcriptomics and functional target validation of brown adipocytes show their complex roles in metabolic homeostasis

Brown adipocytes (BAs) are specialized for adaptive thermogenesis and, upon sympathetic stimulation, activate mitochondrial uncoupling protein (UCP)-1 and oxidize fatty acids to generate heat. The capacity for brown adipose tissue (BAT) to protect against obesity and metabolic disease is recognized, yet information about which signals activate BA, besides β3-adrenergic receptor stimulation, is limited. Using single-cell transcriptomics, we confirmed the presence of mRNAs encoding traditional BAT markers (i.e., UCP1, expressed in 100% of BAs Adrb3, expressed in <50% of BAs) in mouse and have shown single-cell variability (>1000-fold) in their expression at both the mRNA and protein levels. We further identified mRNAs encoding novel markers, orphan GPCRs, and many receptors that bind the classic neurotransmitters, neuropeptides, chemokines, cytokines, and hormones. The transcriptome variability between BAs suggests a much larger range of responsiveness of BAT than previously recognized and that not all BAs function identically. We examined the in vivo functional expression of 12 selected receptors by microinjecting agonists into live mouse BAT and analyzing the metabolic response. In this manner, we expanded the number of known receptors on BAs at least 25-fold, while showing that the expression of classic BA markers is more complex and variable than previously thought.
Designing a network of cOOperating cReative communities for developing a Sharing economy.

"open DOORS" is a proposal which actualizes the "transnational innovative clusterization" process realized within the MED capitalization experience. In fact this proposal is built on the heritage left by 5 capitalization projects which, as one result of the capitalization process, have produced a number of communities, networks and services dealing with creativeness and innovation as drivers for a smart and sustainable growth. _x000D_
Within the present proposal, a chosen number of scientific and institutional partners promotes the creation of a formal Mediterranean network, based on the existing innovative and creative communities, addressing the new global challenge of the Sharing Economy._x000D_
The proposed Study aims to demonstrate how the Sharing Economy can be a driver of economic (business dimension, integrative incomes etc), territorial (subsidiary principle and new available local commodities i.e. transport, accommodation etc which cover public services' gaps) and social (civil society direct participation) growth. It also defines the network's joint strategy and action plan for offering a mix of innovative services to the creative local communities, enabling them to "open the doors" to new forms of collaborative economy. The established "open DOORS network" will be ready, in the next future, to test the innovative services and to develop real and concrete experiences of Sharing Economy.
Cementing links between science and society toward engagement and responsibility

The European Researchers’ Night (ERN) has become an annual tradition in Piedmont thanks to an extraordinary 10 years experience that has made citizens of all ages eagerly awaiting this appointment with the scientific vocation of our district and the European Commission.
The CLOSER project will involve all the 8 provinces of Piedmont and the major city of the Aosta Valley (who recently joined the project), treasuring the capitalized experience of the past editions: it will build on the results achieved along this thrilling journey and move forward, also on the basis of the European agenda defined by H2020 in relation to the science and society issues.
The acronym CLOSER reflects the whole thread of this proposal, which aims at establishing an alliance between researchers and the various societal actors by bringing them closer to one another, using the RRI approach to encourage them to take responsibility and work together to design a sustainable, ethically acceptable and socially desirable future. For this purpose, specific actions will be devised to actively engage citizens, schools and young people, policy makers and industries, who won’t be just the audience but the protagonists of each of the proposed action. A special programme will particularly target young people to foster their interest in scientific careers.
In addition, CLOSER aims at strengthening the European citizenship feeling of the public involved as well as increasing their awareness of the importance of the European dimension in research through specific activities such as the ‘European Stage for Research and Innovation’, ‘A talk with young research!’ and ‘The Human Face of Research’.
To realise such an ambitious programme, the engagement of a large, trans-disciplinary, gender-balanced community of researchers committed to public engagement will be vital: CLOSER will provide them with innovative, creative formats of communication that will strengthen their capability of communicating their research.
Simulation of in-transit services in tracked delivery of project supply chains: a case of telecom industry

Network construction projects in telecommunication industry require large amounts of materials and components available at multiple sites. Items are often customized, valuable and delivered following design specifications subject to frequent changes. When design changes occur, lack of real-time item visibility and traceability can lead to excess inventories at sites, errors, and inefficient transportation. Supply chain digitalization based on Internet-of-Things can mitigate these waste and inefficiency risks. This work aims to estimate the potential benefits of in-transit services based on in-transit control for project network construction operations. Two services are analyzed: Re-direct service based on item re-routing to and reusability for other sites; and Call-back and delivery-on-request services based on centralized collection of items temporarily unneeded at any sites any longer. These services are simulated and evaluated for a telecom network project case study. Experiments show that the in-transit services lead to remarkable improvements mainly of component waste and dwell times.
Flexural Behavior of Reinforced Concrete Beam Strengthened with Carbon Fiber Sheet under Load History

본 연구에서는 합리적인 보강설계를 위하여 기존 철근콘크리트 보에 탄소섬유시트 보강시 하중이력에 따른 휨보강 효과를 분석하였다. 실구조물에서는 다양한 하중이력을 겪은 철근콘크리트보에 보강을 하게 되나 보강시기에 따른 구조물과 보강재료의 초기상태가 고려되지 않으므로 구조물의 안전적 측면과 경제적 측면으로 문제점을 발생시킬 수 있는 요인이 된다. 다양한 하중이력을 거친 RC 보의 변형률 상태를 고려하여 탄소섬유시트 보강에 따른 거동변화를 분석하였다. 휨보강후 거동에 영향을 미치는 변수들에 대하여 보강대상 부재의 하중이력의 영향을 고려한 비선형 단면해석결과 탄소섬유 휨보강보의 보강 후 구조적 성능은 하중이력에 따라 달라지는 것으로 나타났다. 탄소섬유 휨보강보의 휨강도는 하중이력에 크게 영향을 받으므로 설계시 반드시 고려하여야 한다. 【This study examined the flexural strength of CFS reinforced concrete beams with various load histories. The RC beams to be reinforced by CFS have undergone various loading histories but neglecting the loading history results in a few problems in structural safety and cost. Structural behavior of CFS-strengthened RC beams were analyzed considering the strain status of RC beams under loads at the time of CFS strengthening. Nonlinear section analysis showed that the flexural strength of CFS-strengthened RC beams depends on the load history of the RC beams. From the result of this analysis, the flexural strength of a CFS-strengthened concrete beam is affected considerably by the load history and should be considered in CFS reinforcement.】
Transit-oriented Development in the metropolitan governance a comparison between the Colombian case and the South Korean experience

This research studies the process and the political decisions that were carried out in the creation of Seoul Metropolitan Area (SMA) in order to respond to a territorial reorganization associated to a public transport supply that resulted in a model of transit-oriented development (TOD). Contemporaneously, the paper studies the normative framework that governs the metropolitan areas in Colombia and its metropolitan public transport, as well as, it studies the structuring of the metropolitan collective public transport system of the Aburra Valley Metropolitan Area (AVMA). The aim of the research is to understand the process of territorial and transport policy decisions that were held in the SMA, which makes it an example and case of study to contextualize a reorganization of the collective public transportation system in the Colombian case, specifically in the AVMA. The objectives of the research are identifying the regulatory principles of territorial and transport planning, strategies, and instruments used for setting the policy decisions that have a binding character on the operating entities of the collective public transport system. In order to put the characteristics of the AVMA collective public transport bus system in evidence, a comparison between SMA and AVMA was developed. The implications emerged from this comparison are used to generate guidelines through three themes: a) governance; b) financial system and c) operational aspects. The guidelines hope point the reorganization of the public transportation bus system and a future transition to a model of Transport - and People - Oriented Development in the Colombian metropolitan level context.
Moving Ahead for Multimodal Performance Measures: Applying the Charlotte, NC Bicycle and Pedestrian Level of Service Tool in Santa Monica, CA

The urban street design guidelines in Charlotte, NC, USA are an implementation tool for planning and designing “complete streets” in the region. Following their release and adoption in 2007, these guidelines have received a fair deal of praise, including the 2009 U.S. Environmental Protection Agency (EPA) Award for Smart Growth Achievement. They have additionally been lauded for use of context sensitive design and for including a clear institutional process for applying the guidelines to all stages of project delivery. However, with all of these awards and attention, there was relatively little commentary on the bicycle and pedestrian level of service tools created in part with the guidelines.
The secularization theorem in the long nineteenth century

SECULAR aims to analyze how society and politics in 19th century Europe are understood and explained in terms of secularized religious content. This means that modern phenomena are interpreted by reference to earlier, theological categories. The focus is on the social and political theory of the long 19th century, from 1789 to 1914: the phase from the French revolution until the outbreak of WWI, which sees the birth of modern social science as well as the rise of various ideologies. SECULAR studies the idea of secularization as a category fundamental to conceptions of social and historical reality. By centering on the triadic relationship between early socialism, the counter-enlightenment and classical sociology – with special consideration of 19th century Zionism – SECULAR offers new perspectives on how an emerging modern age imagines itself. Guiding general questions are: What is the place of secularization within modern social and political theories? How exactly can social and political facts be described as secularized religious structure? Importantly, how does the theorem of secularization influence and shape historical knowledge? This comparative approach on European ideas and their contexts, understood in the general framework of secularization theory, will offer historiographical and epistemological insights. It adds a new narrative to the entanglement of European social and political ideas. At the same time, SECULAR has a contemporary impact: Social and political theories about the relation between religion and society have a history and this history needs to be studied in order to better comprehend more recent discourses. SECULAR aims at a historical and theoretical understanding of the emergence of the idea of secularization. This understanding will explain the fragmentation, incoherence and interconnectedness of social and political theories in the larger framework of secularization as a key philosophical problem of modernity.
CAN CHANGER AND METHOD FOR CHANGING A CAN

The invention relates to a can changer (100) comprising a receiving region (104) which is designed to receive three cans with respect to its longitudinal extent and which has a first can slider (110) that is designed to travel along the entire receiving region (104) and to receive two cans, wherein the first can slider (110) is designed to receive an empty can (5a) from a feed region (101) and, by being displaced along the pick-up region (104), to press this empty can (5a) against a full can (5c) and thus displace the full can into the region of a discharge path (107), and wherein the empty can (5a) remains in a filling position (105) as a can (5b) to be filled. The invention is characterised in that the receiving region (104) has a second can slider (120) in the region of the discharge path (107), said second can slider being designed to move the full can (5c) onto the discharge path (107). The invention also relates to a method for changing the cans.
Using the Advanced Progressive Matrices (Set I) to assess fluid ability in a short time frame: An item response theory–based analysis.

This article is aimed at evaluating the possibility that Set I of the Advanced Progressive Matrices (APM-Set I) can be employed to assess fluid ability in a short time frame. The APM-Set I was administered to a sample of 1,389 primary and secondary school students. Confirmatory factor analysis attested to the unidimensionality of the scale. Item response theory analyses were applied to investigate the increasing level of item difficulty, test information function, and differential item functioning across gender and age. Additionally, validity measures are reported. Results provide evidence that the APM-Set I can be used as a reliable and valid short form of the Raven's Progressive Matrices in the assessment of fluid ability.
METHOD FOR THE MANUFACTURE OF A MULTILAYER WEB

The invention relates to a method for the manufacture of a multilayer paper or board web containing recycled fiber. The method comprises forming the multilayer web of at least two layers having stock compositions different from each other and diluting the pulp suspension in the formation of each layer with wire water into headbox consistency and feeding it by means of a headbox to a wire section, where the web is dewatered, and joining these layers to form a multilayer web. The method also comprises the step of passing the wire water removed from the wire section in the forming of each layer to be used in the dilution of a pulp suspension, to be fed, of another layer.
T-cell receptor ligation causes Wiskott-Aldrich syndrome protein degradation and F-actin assembly downregulation

Wiskott-Aldrich syndrome protein (WASP) links T-cell receptor (TCR) signaling to the actin cytoskeleton. WASP is normally protected from degradation by the Ca(++)-dependent protease calpain and by the proteasome because of its interaction with the WASP-interacting protein.We investigated whether WASP is degraded after TCR ligation and whether its degradation downregulates F-actin assembly caused by TCR ligation.Primary T cells, Jurkat T cells, and transfected 293T cells were used in immunoprecipitation experiments. Intracellular F-actin content was measured in splenic T cells from wild-type, WASP-deficient, and c-Casitas B-lineage lymphoma (Cbl)-b-deficient mice by using flow cytometry. Calpeptin and MG-132 were used to inhibit calpain and the proteasome, respectively.A fraction of WASP in T cells was degraded by calpain and by the ubiquitin-proteasome pathway after TCR ligation. The Cbl-b and c-Cbl E3 ubiquitin ligases associated with WASP after TCR signaling and caused its ubiquitination. Inhibition of calpain and lack of Cbl-b resulted in a significantly more sustained increase in F-actin content after TCR ligation in wild-type T cells but not in WASP-deficient T cells.TCR ligation causes WASP to be degraded by calpain and to be ubiquitinated by Cbl family E3 ligases, which targets it for destruction by the proteasome. WASP degradation might provide a mechanism for regulating WASP-dependent TCR-driven assembly of F-actin.
Mosquito noise filtering

In one aspect, a method to reduce compression artefacts, includes generating a first set of weights based on pixel value differences, producing a soft binned histogram from values in a neighborhood of pixels, generating an adapted histogram from the soft binned histogram using interpolation, generating occurrence density weights from the adapted histogram, combining the first set of weights and the occurrence density weights, filtering pixel values a bilateral filter using the combined weights, mixing the filtered pixel values and original pixel values, and outputting the mix of filtered pixel values and original pixel values.
Towards the bio-personalization of music recommendation systems: A single-sensor EEG biomarker of subjective music preference

Recent advances in biosensors technology and mobile electroencephalographic (EEG) interfaces have opened new application fields for cognitive monitoring. A computable biomarker for the assessment of spontaneous aesthetic brain responses during music listening is introduced here. It derives from well-established measures of cross-frequency coupling (CFC) and quantifies the music-induced alterations in the dynamic relationships between brain rhythms. During a stage of exploratory analysis, and using the signals from a suitably designed experiment, we established the biomarker, which acts on brain activations recorded over the left prefrontal cortex and focuses on the functional coupling between high-beta and low-gamma oscillations. Based on data from an additional experimental paradigm, we validated the introduced biomarker and showed its relevance for expressing the subjective aesthetic appreciation of a piece of music. Our approach resulted in an affordable tool that can promote human-machine interaction and, by serving as a personalized music annotation strategy, can be potentially integrated into modern flexible music recommendation systems. Keywords: Cross-frequency coupling; Human-computer interaction; Brain-computer interface