SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Global Potential Energy Surface for HO<sub>2</sub><sup>+</sup> Using the CHIPR Method

An analytical potential energy function for the title ion based on the combined hyperbolic inverse power representation (CHIPR) method and its characteristics are discussed at length in the present work. The curves of two diatomic ions, O2+ and OH+, are also obtained within the same approach. The model PES so obtained exhibits extraordinary flexibility in describing with subchemical accuracy even the weak topological features near the higher energy regions. Thus, structural properties predicted by the model may help spectroscopists who want to compare their experimental values with the ones from theory. The relaxed PESs in various coordinates have been calculated by relaxing the O2 bond distance using the present model, thus throwing light on all the possible isomers and their interconversions. The latest estimates of IR frequencies for three vibrational modes have been compared with the computed frequencies using the present model, and the agreement seems encouraging.
Bourdieu face à la littérature

I have used Pierre Bourdieu’s sociological approach as a critical tool for the study of literary texts. As a sociologist, Bourdieu is not satisfied with the notion that the literary text would be isolated from the world and considers the writer as a product of economic, social, religious or political circumstances that may be recovered through analysis. According to Bourdieu, the development of literature as an independent field goes hand in hand with the expansion of a liberal politics, a connection critics refuse to recognize as they will believe in the myth of inspired creation. Bourdieu retraces to the nineteenth century the moment when literature became independent and describes how twentieth-century literature is but a perpetuation of nineteenth-century literary myths. I also look at the ways the specialists of Flaubert responded to the publication of Les Regles de l’art as the book provoked heated debates when it was issued. I have especially examined the arguments of critics hostile to Bourdieu in order to demonstrate how such an emblematic figure as Flaubert embodies what is at stake when one questions the notion of literature. How can Bourdieu fit in literary studies? One has to be careful interpreting the title of Bourdieu’s book. Les Regles de l’art is no prescriptive book : Bourdieu is not the one who sets the rule nor does he suggest that there were no rules before the advent of the modern age. He is simply trying to show how, from the start of this period, the literary world is determined by specific social, political, economic and cultural conditions and questions the particular role played by the artist in this new state of things.
Unravelling the mode of action of mucosal adjuvants

The development of new vaccines against infectious diseases is a major worldwide public health objective. Despite the availability of antimicrobial therapies, vaccines still constitute the most effective means of controlling infections. Adjuvants are crucial for increasing the onset, magnitude, diversity and memory of immune responses to vaccines. Whereas a range of adjuvants is available for conventional vaccination routes, there are currently no mucosal adjuvants for promoting the neutralization of respiratory, gastrointestinal or urogenital infections at the pathogens' port of entry. This proposal will focus on (i) performing innovative research on mucosal adjuvants' mode of action and (ii) catalysing the mid-term development of novel, safe, efficient vaccines for nasal or oral administration.
Adjuvants that specifically target Toll-like receptors are efficacious in mucosal vaccination because they trigger mucosal immunity (including secretory antibodies). The host laboratory has a longstanding research programme on the mucosal adjuvant activity of a Toll-like receptor 5 agonist (namely flagellin). Recent results have suggested that cross talk between epithelial cells and mucosal dendritic cells drives flagellin's adjuvant activity. The present project aims at identifying (i) signals from flagellin-stimulated epithelial cells that are of paramount importance in the transactivation of dendritic cells, (ii) dendritic cell factors that condition T and B lymphocytes to produce specific mucosal immune responses, and (iii) unique features of memory responses in the mucosa. This proposal will provide unprecedented opportunities for characterizing mucosal adjuvants. Moreover, better knowledge of the mechanism underlying flagellin's action would not only shed light on the latter's properties but also aid the development of better, safer adjuvants. The overall objective is to generate significant new insights into the field of adjuvants and vaccines.
Governance of Regionally Integrated Projects using Innovative Tools.Structural funds implementation in an integrated approach

Implementing EU policies has become an important task for public authorities at the regional and local levels across Europe. In particular when receiving and processing EU Structural Funds for the development of their regions, public authorities are facing demanding tasks of programme and project management. To enhance their administrative and project generating capacities for successful Structural Funds management regional institutions need to be well informed about tools such as project cycle management or integrated project management. The Regional Framework Operation “GRIP_IT: Governance of Regionally Integrated Projects using Innovative Tools” aims at promoting good practices and developing innovative methods for programming and implementing Structural Funds investments in their regions. This includes the development of a pipeline of well-crafted projects, governance arrangements for involving local actors, project appraisal and selection, reporting and payment, monitoring and evaluation. RFO subprojects will, among others, focus on developing training tools, exchanging experts, developing and testing innovative governance and management tools and elaborating guidelines. Subprojects will also focus on public-private-partnership within integrated projects and Operational Programmes. The operation “GRIP_IT” results in improved capacity of regional public actors for designing and managing effective Structural Funds interventions in their regions. GRIP_IT enables its partner administrations to successfully apply innovative governance and management tools for the next programming period of the Structural funds. Activities include the organisation of interregional meetings and conferences, information days and seminars about integrated project governance, identification of best practises and exchange of experts.
Is there variety × isolate interaction in the polygenic quantitative resistance of carrot to Alternaria dauci?

Horizontal and polygenic resistance is race-nonspecific and, therefore, more durable, unlike vertical resistance, which is race-specific and unstable. However, this division is perhaps not so obvious since some cultivar × isolate interactions have already been observed for plant species with partial resistance. Carrot is known to be partially resistant to Alternaria dauci, but it is relevant for breeders to study cultivar × isolate interactions in order to develop durable resistant varieties. For this purpose, 12 highly diverse carrot genotypes and one segregating population were inoculated in a tunnel or in a glass house with 11 isolates of A. dauci that also represented a high diversity in terms of geographical origin, aggressiveness and genetic diversity. Disease severity values were assessed three times in the tunnel in a one-year experiment (2002) and twice in the glass house in an experiment over two consecutive years (2011 and 2012). The interaction of isolate with genotype was non-significant in the tunnel, and the same result was obtained in the glasshouse for both years of study except for the first scoring date in 2011, suggesting that the partial resistance of carrot to A. dauci is probably mainly explained by major QTLs that confer resistance to a large number of isolates and, potentially, some minor isolate-specific QTLs as well.
What Predicts and what Mediates the response of urge urinary incontinence to biofeedback?

To better target a behavioral approach for urge urinary incontinence (UUI) and enhance its efficacy by (1) identifying predictors of response to biofeedback-assisted pelvic muscle training (BFB), and (2) determining factors that mediate response.BFB (four biweekly visits) was administered to 183 women > 60 years (mean = 73.6). Before and after intervention, all underwent comprehensive evaluation and videourodynamic testing. Postulated predictors and mediators from four urodynamic domains, specified a priori, were correlated with reduction in UUI frequency.Median UUI frequency decreased from 3.2/day to 1/day (P =0.0001). UUI improved by ≥50% in 55% of subjects and by 100% in 13% of subjects. Frequent UUI predicted poor response (P < 0.01). Of the urodynamic parameters, only high amplitude and briskness of detrusor overactivity (DO) predicted decreased response (P < 0.05 and P < 0.01) and these could be measured only in the 43% of subjects with elicitable DO. Decreased DO elicitability was the only urodynamic variable that changed in concert with improvement and thus was a candidate mediator. Response was neither predicted nor mediated by proprioception/warning, cystometric capacity, detrusor contractility, sphincter strength, or baseline DO elicitability.Severe DO predicts poor response to BFB. Good response is mediated by reduction in DO elicitability. Other than baseline UUI frequency, there are no other clinically or urodynamically important predictors or mediators of BFB response in this population. BFB may be best for patients with less severe DO. Future research to enhance its efficacy might better focus on the brain than on the lower urinary tract.
Spatial variability in size at maturity of golden king crab ( Lithodes aequispinus ) and implications for fisheries management

Many crab fisheries around the world are managed by size, sex and season, where males are given at least one opportunity to reproduce before being harvested. Golden king crab ( Lithodes aequispinus ) supports a commercial fishery in Southeast Alaska and legal size is based on growth and maturity information from other parts of their range. Size-at-maturity estimates varied for crabs among seven management areas in Southeast Alaska, where male maturity estimates increased in size with increases in latitude, while maturity estimates across their North Pacific range decreased in size with increases in latitude. Depth, temperature and harvest history were not related to variation observed in male maturity estimates. Management implications from this research include reducing legal size in some areas to maximize harvest potential and increasing in others to allow male crabs the opportunity to reproduce before being harvested. A more conservative strategy would incorporate the largest maturity estimate, thus increasing the legal size which would have a negative impact to the commercial fishery, but allow male crabs the opportunity to reproduce before being harvested. This study shows the importance of understanding how life-history characteristics change over space and the challenge incorporating spatial variability for improved fisheries management.
USE OF CYCLIC ACETALS/KETALS FOR IMPROVED PENETRATION OF ACTIVE SUBSTANCES INTO CELLS AND ORGANS

The invention relates to the use of certain cyclic acetals or ketals for improving the penetration of pharmaceutical agents into cells and organs.
Evaluation of the regional climate model ALADIN to simulate the climate over North America in the CORDEX framework

In this study, an ensemble of four multi-year climate simulations is performed with the regional climate model ALADIN to evaluate its ability to simulate the climate over North America in the CORDEX framework. The simulations differ in their driving fields (ERA-40 or ERA-Interim) and the nudging technique (with or without large-scale nudging). The validation of the simulated 2-m temperature and precipitation with observationally-based gridded data sets shows that ALADIN performs similarly to other regional climate models that are commonly used over North America. Large-scale nudging improves the temporal correlation of the atmospheric circulation between ALADIN and its driving field, and also reduces the warm and dry summer biases in central North America. The differences between the simulations driven with different reanalyses are small and are likely related to the regional climate model’s induced internal variability. In general, the impact of different driving fields on ALADIN is smaller than that of large-scale nudging. The analysis of the multi-year simulations over the prairie and the east taiga indicates that the ALADIN 2-m temperature and precipitation interannual variability is similar or larger than that observed. Finally, a comparison of the simulations with observations for the summer 1993 shows that ALADIN underestimates the flood in central North America mainly due to its systematic dry bias in this region. Overall, the results indicate that ALADIN can produce a valuable contribution to CORDEX over North America.
Acute Effects of Static Stretching on Bench Press Power and Velocity in Adolescent Male Athletes

The purpose was to examine the acute effect of pre-exercise static stretching on barbell power and velocity during the bench press exercise. Forty male high school athletes performed 1 repetition maximum (1 RM) testing and were divided into either a static stretching (SS), or a no stretching (NS) protocol. Subjects performed 1 set of 3 repetitions of the bench press with 50% 1 RM as a warm-up. SS then performed a series of stretching exercises for the involved muscles. After completing either the bench press warm-up or the stretching protocol, subjects executed one bench press repetition at 85% 1 RM. After 24 hours, the groups switched protocols. Concentric mean barbell power and velocity were measured during the 85% lift. Stretching resulted in significantly lower mean power (NS=366.6±115.7 W, SS=282.7±111.4W) and mean velocity (NS=0.413±0.103 m×s −1 , SS=0.302±0.086 m·s −1 ) when compared to NS. Static stretching has an acute detrimental effect on muscular performance.
Three-Dimensional Positron Annihilation Momentum Measurement Technique Applied To Measure Oxygen-Atom Defects in 6H Silicon Carbide

Abstract : A three-dimensional Positron Annihilation Spectroscopy System (3DPASS) capable to simultaneously measure three-dimensional electron-positron momentum densities measuring photons derived from annihilation events was designed and characterized. 3DPASS simultaneously collects a single data set of correlated energies and positions for two coincident annihilation photons using solid-state double-sided strip detectors (DSSD). Positions of photons were determined using an interpolation method which measures a figure-of-merit proportional to the areas of transient charges induced on both charge collection strips directly adjacent to the charge collection strips interacting with the annihilation photons. The subpixel resolution was measured for both double-sided strip detectors (DSSD) and quantified using a new method modeled after a Gaussian point-spread function with a circular aperture. Error associated with location interpolation within an intrinsic pixel in each of the DSSDs, the subpixel resolution, was on the order of 0.20 mm (this represents one-standard deviation). The subpixel resolution achieved was less than one twenty-fifth of the 25-mm2 square area of an intrinsic pixel created by the intersection of the DSSDs' orthogonal charge collection strips. The 2D ACAR and CDBAR response for single-crystal copper and 6H silicon carbide (6H SiC) was compared with results in the literature. Two additional samples of 6H SiC were irradiated with 24 MeV O+ ions, one annealed and one un-annealed, and measured using 3DPASS. Three-dimensional momentum distributions with correlated energies and coincident annihilation photons' positions were presented for all three 6H SiC samples. 3DPASS was used for the first experimental PAS measurement of the structure of oxygen defects in bulk 6H SiC.
Spectroscopic Investigations of Catalase Compound II: Characterization of an Iron(IV) Hydroxide Intermediate in a Non-thiolate-Ligated Heme Enzyme

We report on the protonation state of Helicobacter pylori catalase compound II. UV/visible, Mössbauer, and X-ray absorption spectroscopies have been used to examine the intermediate from pH 5 to 14. We have determined that HPC-II exists in an iron(IV) hydroxide state up to pH 11. Above this pH, the iron(IV) hydroxide complex transitions to a new species (pKa = 13.1) with Mössbauer parameters that are indicative of an iron(IV)-oxo intermediate. Recently, we discussed a role for an elevated compound II pKa in diminishing the compound I reduction potential. This has the effect of shifting the thermodynamic landscape toward the two-electron chemistry that is critical for catalase function. In catalase, a diminished potential would increase the selectivity for peroxide disproportionation over off-pathway one-electron chemistry, reducing the buildup of the inactive compound II state and reducing the need for energetically expensive electron donor molecules.
Quadratic dispersive resonators for optical frequency comb generation

Optical frequency combs are made of thousands of equally spaced spectral lines, each an ultra-stable laser in its own right. They act as “spectral rulers” against which unknown optical frequencies can be measured, and they have had a revolutionary impact on numerous fields ranging from the detection of extra-solar planets to precision metrology, winning its inventors a Nobel prize in 2005. Traditionally, frequency combs have been generated by ultrashort pulsed lasers, but in 2007 an important observation changed the research landscape: a continuous-wave laser coupled into a microscopic resonator was shown to spontaneously transform into thousands of comb lines via third-order nonlinear optical effects. I believe that yet another revolution lies at the horizon. Specifically, recent experiments have alluded to the possibility of realizing optical frequency combs purely through second order (quadratic) nonlinear effects. The intrinsic features of the second order nonlinearity hold promise to deliver access to new regions of the electro-magnetic spectrum beyond all conventional frequency comb technologies. But unfortunately, experimental investigations are scarce and the physics that underlie frequency comb formation in quadratic resonators is poorly understood. The goal of the QuadraComb project is to pursue a complete characterization of frequency comb generation in dispersive quadratically nonlinear resonators. I plan to (i) develop theoretical models to describe quadratic frequency combs, and (ii) develop novel platforms for the experimental realization of quadratic frequency combs.
Stalling the replication fork via the impedimental stabilization of higher-order dnas

Cancer is a generic term for a group of diseases characterized by the uncontrolled growth and spread of cells with abnormal proliferating activity. Most of the anticancer drugs currently used in the clinic trigger irreversible DNA damages and thus, promote replicative stress. As an alternative of irreversible DNA strand breaks, the non-covalent small-molecule stabilization of unusual, non-B DNA structures has emerged as a promising way to create DNA damages. One of such non B-DNA structures is a three-way DNA junction that might fold both upstream and downstream of the replication fork. The stabilization of three-way junctions by small molecules therefore opens a promising way to induce replicative stress in a highly cancer-specific manner. The main goal of the project ""STARFISH DNA"" (for ""Stalling the Replication Fork via the Impedimental Stabilization of Higher-order DNAs"") is to identify a new series of compounds capable of creating DNA damages through three-way junction stabilization and to use them either as standalone therapeutic agent to fight against cancers or in combination with established drugs that disrupt cancer signaling pathways in a synergistic manner.
Population dynamics of two caprellid species (Crustaceae: Amphipoda: Caprellidae) from shallow hard bottom assemblages

The community structure of caprellids associated with shallow hard bottom assemblages was studied in four locations around Pagasitikos Gulf, western coast of the Aegean Sea. Samplings were carried out every 3 months from April 2009 to April 2010. Samples were collected by scraping off the hard substrate, using 400-cm2 handmade quadrate samplers. Water temperature, pH, salinity, dissolved oxygen and sea current velocity were measured in situ. Two caprellid species were found, Caprella acanthifera and Phtisica marina, with a clear dominance of C. acanthifera at all locations. The abundance of both species followed a seasonal pattern with a peak in spring or summer and a decline in winter. Lower abundances were detected at the locations with high current velocity and higher abundances at the locations with low water flow speed. This is an indication that the species might prefer areas with low hydrodynamism. Strong sexual dimorphism in body size was observed for both species, and the sex ratio was 1:1 throughout the samplings. It appears that reproduction for both species is continuous throughout the year, with a possible major breeding event in winter.
Real-time capable first principle based modelling of tokamak turbulent transport

A real-time capable core turbulence tokamak transport model is developed. This model is constructed from the regularized nonlinear regression of quasilinear gyrokinetic transport code output. The regression is performed with a multilayer perceptron neural network. The transport code input for the neural network training set consists of five dimensions, and is limited to adiabatic electrons. The neural network model successfully reproduces transport fluxes predicted by the original quasilinear model, while gaining five orders of magnitude in computation time. The model is implemented in a real-time capable tokamak simulator, and simulates a 300s ITER discharge in 10s. This proof-of-principle for regression based transport models anticipates a significant widening of input space dimensionality and physics realism for future training sets. This aims to provide unprecedented computational speed coupled with first-principle based physics for real-time control and integrated modelling applications.
Modified diatomite-supported CuO–TiO 2 composite: Preparation, characterization and catalytic CO oxidation

Abstract Modified diatomite (acid treated and ZrO 2 -coated diatomite) coated by nano copper and titanium mixed oxides was used to investigate the catalytic oxidation of carbon monoxide. The prepared catalysts were characterized by Brunauer–Emmett–Teller (BET) surface area, field emission scanning electron microscope (FESEM), X-ray diffraction (XRD), temperature-programmed reduction (TPR), porosimetry, and X-ray photoelectron spectroscopy (XPS). Catalytic behavior for CO oxidation was studied in different conditions in a tubular reactor packed with catalyst. The variation of catalytic activity of the prepared composite catalysts with different molar fractions of CuO and TiO 2 for CO oxidation in different reaction temperatures was investigated. The catalytic activity of catalyst was dependent on the concentration of coated catalyst over diatomite, reaction temperature and retention time. The results illustrated that diatomite is the promising candidate for catalyst support due to its unique characteristics. It was found that CO conversion of 100% can be achieved at 220 °C over catalyst with 70 mol% CuO and 30 mol% TiO 2 content.