SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Repurposing of carbamazepine for treatment of skeletal dysplasia

Genetic skeletal diseases (GSDs) are an extremely diverse and complex group of rare genetic diseases that affect the development the skeleton. There are more than 450 unique and well-characterised phenotypes that range in severity from relatively mild to severe and lethal forms. Although individually rare, as a group of related genetic skeletal diseases, GSDs have an overall prevalence of at least 1 per 4,000 children, which extrapolates to a minimum of 225,000 people in the 27 member states and candidate countries of the EU. This burden in pain and disability leads to poor quality of life and high healthcare costs. 
Metaphyseal chondrodysplasia, type Schmid (MCDS) results from mutations in collagen X and affects <1/100,000 of the population. Mutant collagen X molecules miss-fold during synthesis and are retained within the endoplasmic reticulum (ER) of hypertrophic chondrocytes, thereby causing ER stress. Our extensive pre-clinical studies have shown that carbamazepine (CBZ) can alleviate ER stress caused by the expression of mutant collagen X and restore bone growth in a validated mouse model of MCDS. CBZ is an FDA approved drug used for the treatment of epilepsy and bipolar disorder and received orphan drug designation by the European Commission for the treatment of MCDS in September 2016.
MCDS-Therapy is a 5-year collaborative project comprising world-renown clinical centres and SMEs to advance the repurposing of CBZ for MCDS (up to the Marketing Authorization Application dossier) through a multicentre and multinational (EU & AUS) clinical trial (Phase1, Phase2/3). MCDS-Therapy also encompasses biomarker development and health economics assessment studies to deliver by 2022 an innovative and affordable (CBZ already exists in a generic form) repurposed therapy for MCDS along with the diagnosis/prognosis tools to personalise the treatment strategy.
BEDDING ELEMENTS

The invention concerns bedding elements, in particular a slip cover (200) for a bedding element for receiving at least one quilt comprising a first main piece of cloth and a second main piece of cloth mutually assembled by their side edges, which is reversible and comprises at least one supporting device (500) having the shape of a rectangular parallelepiped open on one of its faces, and capable of matching the shape of a mattress (1).
Investigating Race, Class and Context through Historical Evidence: Segregation and the Ecology of Aspirations of Black College Students in the 1960s South

In an era of re-segregation among school systems in the United States, we find ourselves revisiting times of forced school segregation (pre Brown v. Board) for a better understanding of explanations and potential consequences. One consequence, depressed aspirations for occupational mobility, is examined here. Using data for Mathews and Prothro's Negro Participation Survey, administered to black college students in 1961, we examine this relationship while controlling for various individual level indicators of capital, demographics, political participation, and ecologically-centered organizational and economic factors through the use of Hierarchical Linear Modeling (HLM). We uncover patterns of aspirations (or lack thereof) concerning social class mobility that are directly related to social class background and the cultural orientations of the environment in which the student hails. Our conclusions link such patterns to the current trajectory of re-segregation in the education system.
Ultra-Personalization and Decentralization: The Potential of Multi-Agent Systems in Personal and Informal Learning

Agents are autonomous software components that work with one another in a decentralized fashion to achieve some end. Agent systems have been used in Technology Enhanced Learning (TEL) before, but these applications seldom take advantage of the fact that each agent may have its own goals and strategies, which makes agent systems an attractive way of providing personalized learning. In particular, since agents can solve problems in a decentralized way, this makes them an attractive way of supporting informal learning. In this paper we use scenarios to examine how common problem solving techniques from the agents world (voting, coalition formation and auction systems) map to significant challenges for personalized and informal learning in the TEL world. Through an agent simulation we then show how an agent system might perform in one of those scenarios and explore how different agent strategies might influence the outcome. Based on this work we argue that agent systems provide a way of providing ultra-personalization of the learning process in a decentralized way and highlight equitability and scrutability as two key challenges for future investigation.KeywordsAgent SystemsPersonalized LearningInformal Learning
Exploring the Link Between Procedural Fairness and Union Membership in the Federal Government

Little research focuses on how management in the public sector influences outcomes relevant to unions, such as membership rates. Membership is a particularly vexing union problem in right-to-work environments, such as the federal government, where no requirements exist for any dues payments. This research addresses the association between perceptions of the fairness of management decisionmaking procedures and the propensity to pay union dues in the federal government. An increase in the perception that management makes decisions fairly is associated with a decreased likelihood that a federal employee will choose to be a member of a union. Likewise, minorities appeared more likely than non-minorities to be union members, when controlling for other factors.
Method and system for pre-ignition control

Methods and systems are provided for improving the detection and mitigation of high speed pre-ignition. In one example, high speed pre-ignition is detected based on concurrent or sequential changes in an integrated knock sensor output in a knock window as well as a pre-ignition window. The high speed pre-ignition is addressed using cylinder fuel deactivation and/or engine load limiting to reduce the risk for run-away pre-ignition.
Lessons from water scarcity of the 2008–2009 Gwangdong reservoir: needs to address drought management with the adaptiveness concept

Numerous publications document increasing consensus in the scientific community that climate change will increase the severity and frequency of drought. However, constructing large infrastructures is often viewed as an unreliable and inefficient option in dealing with the problem of drought, owing to unpredictability of climate change. This study aims at illustratively presenting that there is much room to improve drought management without resorting solely to infrastructure options. The adaptiveness concept is first explained to examine the reasons of failure in drought management and appropriate options from the viewpoint of a systems approach. Thereafter, a Korean water scarcity case is defined as the system dynamics model. The model is implemented to include movement of water via the reservoir and water supply facilities, the operating rules of the reservoir, and the relation between water scarcity and customer stress. Simulation results demonstrate that adaptiveness of drought management was low because of untimely or limited options of the reservoir operator. They also show that most customer stress could be largely mitigated by two options chosen from the adaptiveness concept. It is finally concluded that drought management needs to be addressed with consideration of the adaptiveness concept before deciding solely on expansion of infrastructure upon facing challenges due to climate change.
Dust charge measurements by the Lunar Dust Experiment

The Lunar Dust Experiment (LDEX) onboard the Lunar Atmosphere and Dust Environment Explorer (LADEE) mission discovered a permanently present dust cloud engulfing the Moon. The size, velocity, and density distributions of the dust particles are consistent with ejecta clouds generated from the continual bombardment of the lunar surface by sporadic interplanetary dust particles. Intermittent density enhancements were observed during several of the annual meteoroid streams, especially during the Geminids. In addition to the mass and speed of the impacting particles, in a significant fraction of the events, LDEX also recorded the electrostatic charge of the dust grains before their impact. Here we report on the initial analysis of the LDEX dust charge measurements.
Finnish spectrolite as high-dose gamma detector

Abstract A natural material called spectrolite, from Finland, was studied in this work. The purpose was to test it in gamma radiation beams to verify its performance as a high-dose detector. From this material, pellets were manufactured with two different concentrations of Teflon and spectrolite, and their responses were verified using two luminescent techniques: thermoluminescence (TL) and optically stimulated luminescence (OSL). The TL and OSL signals were evaluated by means of characterization tests of the material response, after exposure to a nominal absorbed dose interval of 5 Gy to 10 kGy. The results obtained, for both concentrations, showed a good performance of this material in beams of high-dose gamma radiation. Both techniques were utilized in order to investigate the properties of the spectrolite+Teflon samples for different applications.
Project UNIVERSITAS - A CEI International University in the cross-border area between Italy and Slovenia. Possible scenarios of opportunities for the territory 

Project “Universitas” aims at monitoring territorial resources in the Italian-Slovenian cross-border area of Trieste- Koper/Capodistria and Gorizia/Nova Gorica, in view of the creation and implementation of international cooperation projects among Universities in Central and South-Eastern Europe. The research, carried out by the Friuli Venezia Giulia Section of the Jacques Maritain International Institute consists in the analysis of three models of university cooperation, to determine their feasibility. The models are: network (establishment of university networks on individual educational or research projects), inter-faculty (joint establishment of faculties through seconded human resources from participating universities), and new university (creation of a new university with new or seconded staff). A technical international research team is charged, additionally, with identifying on site the subjects of excellence in the educational, cultural, and institutional sector who can support the creation of an InCE University. To this end, the project aims at assessing the potential of the Italian-Slovenian crossborder territory, the actual educational offer, the institutional synergies, the expectations and willingness of the economic operators; enhancing advanced education in an international context as a resource for cross-border development; contributing to the promotion of cooperation in border areas in the field of research and education; as well as encouraging greater integration in the border area through a common approach and a strategic project in the field of education. In addition to the research activity, the initiative also envisages an information phase consisting in the creation of a database - containing information on the educational supply and demand and on the legislative framework of Central and South-Eastern European Countries - a CD Rom and a project website, where the results are published and presented on the occasion of a closing conference.
TAX CREDIT — SISA SICILIA SPA

THE INVESTMENT CONSISTS OF THE PURCHASE OF A WHOLE SERIES OF ELECTRONIC MACHINES THAT WILL BE USED FOR MODERNISATION AND COMPUTERISATION
Factors associated with condom use among young adult ecstasy users

This paper examines the prevalence of and the factors associated with condom use in a sample of 283 young adult ecstasy users.The study, which relied upon targeted sampling and ethnographic mapping, took place between 2002 and 2004. It entailed conducting two-hour-long, face-to-face interviews in the Atlanta, Georgia metropolitan area.Condom use was inconsistent; only 35.2% of all sex acts were protected. Using multiple regression, five factors were related to condom use: race (Caucasians used condoms less than other groups), income (lower income = greater condom use), relationship status (persons involved in relationships reported less condom use than those who were not "involved"), multiple sex partners (multiple sex partners = more condom use), and condom use self-efficacy (higher efficacy level = more condom use).Condom use rates were not optimal in this population. In particular, targeted interventions are needed for Caucasian ecstasy users. Intervention efforts ought to address relationship (in)fidelity as it pertains to engaging in safer sex practices, especially among persons involved in relationships. Intervention efforts also need to work to increase condom use self-efficacy.
Thermochemical hydrogen production in a solar structured reactor:facing the challenges and beyond

The HYDROSOL-beyond proposed action is a continuation of the HYDROSOL-technology series of projects based on the utilization of concentrated solar thermal power for the production of Hydrogen from the dissociation of water via redox-pair-based thermochemical cycles. HYDROSOL-beyond is an ambitious scientific endeavor aiming to address the major challenges and bottlenecks identified during the previous projects and further boost the performance of the technology via innovative solutions that will increase the potential of the technology’s future commercialization. In this context, HYDROSOL-beyond will capitalize on the 750kWth existing operational infrastructure, built in the HYDROSOL-Plant project, as well as on a “cluster” of relevant solar platforms and units (owned & operated by the project partners) in order to collect diverse experimental data from a wide range of achievable solar power (50-750kWth) facilities. This way HYDROSOL-beyond will have the flexibility of assessing the proposed novel approaches both under realistic environments and at different scales. The main objectives of HYDROSOL-beyond are: 
• the minimization of the parasitic loses mostly related to the high consumption of inert gas via the introduction of innovative concepts for the purification and the potential full recycling of the utilized gases
• the efficient recovery of heat at rates >60%
• the development of redox materials and structures with enhanced stability (>1,000 cycles) and with production of hydrogen ~three times higher than the current state-of-the-art Ni-ferrite foams 
• the development of a technology with annual solar-to-fuel efficiency of ≥10%
• the improvement of the reactor design and introduction of novel reactor concepts 
• the development of smart process control strategies and systems for the optimized operation of the plant 
• the demonstration of efficiency >5% in the field tests, i.e. during operation at the 750kWth HYDROSOL solar platform (PSA, Spain)
Oceanic carbon cycling response to global temperature changes

Human-caused emissions of carbon dioxide are disrupting the natural variations of the carbon cycle. Past climatic variations provide essential information on the carbon cycling and its associated climate changes to explore different scenarios from unrestrained to even decreased emissions of CO2. In the CYCLOCARB project, we will develop a semi empirical model of carbon cycling and climates over the last glacial cycle, a unique dampened natural analogue for expected anthropogenic forcing’s. This semi-empirical model will be constrained by an extensive database including indicators for temperature and ice volume (δ18O of foraminifers, sea surface temperature proxies) and proxies for global carbon cycling and partitioning between ocean, atmosphere and solid earth (δ13C of foraminifers, carbonate, organic carbon content in marine sediment). Temperature proxies’ records will help refining climatic sensitivity to greenhouse gases, and the temporal evolution of temperature pattern will shed light on the response of the oceans to climate forcing’s. The δ13C of the climatic system will be reconstructed and the effect of the biological pump quantified for the last 150ka, encompassing both a major emission event at termination II and some decreased CO2 intervals. Altogether, our climatic reconstructions and the semi-empirical model will improve our understanding of the natural response of the carbon cycling to anthropic changes. Moreover, CYCLOCARB will permit the quantification of carbon stocks in Exclusive Economic Zones, which could affect Europe national greenhouse gases inventories and marine carbon stock management.
On the evolution of fleshy fruits: an integrative test to assess the relative role of intrinsic and extrinsic factors in shaping fruit type

A trip to a grocery store exposes us to an outstanding diversity of fruits. While this variety was influenced by human selection during plant domestication, it mainly reflects strategies of seed dispersal that evolved over millions of years. Despite the huge variation in fruit color, shape, and size, common patterns can still be identified, especially the repeated evolution of fleshy fruits (e.g. olives, apples, tomatoes). Though this pattern is well observed, we are still exploring the role of different factors and their selective pressures. These can be intrinsic, as evolution of inherited genes determining fruit traits, or extrinsic, as the environment. To date, studies have focused on one or two major factors at a time, but their relative contributions requires an integrative analysis.
FRUITFUL will dissect the evolution of fleshy fruits in the olive family. Oleaceae is the ideal study subject here because it presents a natural comparative set-up for fruit evolution: multiple lineages that independently evolved fleshy fruits; species living in a variety of environments; and diverse seed dispersers. Further, several genomes and transcriptomes of Oleaceae were recently released.
In this project, I will: (1) identify independent transitions to fleshy fruit within a comprehensive phylogenetic framework of Oleaceae; (2) use phylogenomic approaches to analyze representative genes in species with fleshy or dry fruits, and test for switches in selective pressures in relation to trait transitions; (3) estimate the historical biogeography of the family, along with current environmental preferences of species, and their seed dispersers; and finally, (4) integrate all results in models of causal relationships, and identify direct and indirect effects, and their magnitudes, among variables and fruit type. FRUITFUL’s interdisciplinary research and novel integrative approach will provide new insights into understanding the patterns observed at a macroevolutionary scale.
USING RATIONAL NUMBERS AND PARALLEL COMPUTING TO EFFICIENTLY AVOID ROUND-OFF ERRORS ON MAP SIMPLIFICATION

This paper presents EPLSimp, an algorithm for map generalization that avoids the creation of topological inconsistencies. EPLSimp is based on Visvalingam-Whyatt's (VW) algorithm on which least “important” points are removed first. Unlike VW's algorithm, when a point is deleted a verification is performed in order to check if this deletion would create topological inconsistencies. This was done by using arbitrary precision rational numbers to completely avoid errors caused by floating-point arithmetic. EPLSimp was carefully implemented to be efficient, although using rational numbers adds an overhead to the computation. This efficiency was achieved by using a uniform grid for indexing the geometric data and parallel computing to speed up the process. As result, simplified models completely free of topologically inconsistent results and round-off errors due to the use of multiple precision rational numbers. In addition, there was a considerable speedup arising from the use of parallel computing.
Co-opted directors, gender diversity, and crash risk: evidence from China

This study examines how the composition of the board of directors at Chinese firms affects crash risk. The results indicate that co-opted directors (i.e., directors appointed after the CEO assumed office) have a positive and significant effect on crash risk; the positive relation between board directors and crash risk is primarily driven by co-opted male directors, implying a gender difference on crash risk. Non-co-opted independent directors mitigate crash risk, but the negative relation between gender and crash risk is much stronger for female directors than for male directors. The results indicate that co-option/non-co-opted independence along with gender diversity on the board plays an important role in shaping crash risk behaviors. The director-crash risk linkage disappears at state-owned enterprises, suggesting that ownership structure affects board behaviors and board members play the role of rubber-stamp. Finally, the relation between gender and crash risk is more pronounced at crash-risk prone firms with high earnings management and high financial leverage.
Analysis of the German Perinatal Survey of the Years 2007–2011 and Comparison with Data from 1995–1997: Neonatal Characteristics and Duration of Pregnancy

We have previously analysed neonatal characteristics and duration of pregnancy in Germany based on data from the German Perinatal Survey of 1995-1997. Here we describe neonatal characteristics and duration of pregnancy based on the German Perinatal Survey of 2007-2011.We had been provided with data from the German Perinatal Survey of 1995-1997 by the chambers of physicians of all the states of Germany except Baden-Württemberg (1 815 318 singleton neonates). We were also provided with access to the perinatal survey data of 2007-2011 by the AQUA Institute in Göttingen, Germany (3 187 920 singleton neonates). We investigated regional differences within Germany and also compared the 2 periods of time. We used the computer programme SPSS for data analysis and performed plausibility checks on the survey data.Comparing the states of Germany, we found that birth weight was largest for neonates born in Schleswig-Holstein (3 407 g) and Mecklenburg-Western Pomerania (3 392 g); the lowest mean birth weight was observed in the Saarland (3 283 g). Preterm birth rate varied between 6.3% (Saxony) and 8.1% (Bremen, Saarland). Comparing 1995-1997 vs. 2007-2011, deliveries after 37 and 38 weeks of gestation were more common and deliveries after 39 and more weeks of gestation were less common in the later period of time.Regional differences in the anthropometric characteristics of neonates exist between the states of Germany. The proportion of deliveries after 39 and more weeks of gestation has decreased.
(14508.17092020.172001046) NEUE SANCOM

DAS UNTERNEHMEN BESCHÄFTIGT SICH MIT DER EIGENEN PRODUKTION UND VERARBEITUNG IM AUFTRAG DRITTER VON TEILEN UND ZUBEHÖR FÜR CALZATURE.THE INVESTITIONSPROJEKT PRÄSENTIERT RIGUARDA:MANUTENZIONE STROARIDNARIA IMMOBILIEN: DIE INTERVENTION IN DAS PROJEKT? ZIELT AUF DIE RÜCKGEWINNUNG DER ABDECKUNG DER PRODUKTIVEN EIGENSCHAFT DURCH ENTFERNEN UND ENTSORGEN VON ASBESTZEMENTPLATTEN. WIRD DIE INTERVENTION BETROFFEN SEIN? AUCH DIE ALLGEMEINE NEUENTWICKLUNG DER EDIFICIOSPESE TECHNIKEN DES BAUMANAGEMENTS: KOSTEN FÜR DIE PLANUNG UND VERWALTUNG DER FÜR DIE TÄTIGKEIT FUNKTIONALEN LKWS? VON IMPRESEACQUISTO VON FORMEN, AUSRÜSTUNG FÜR MEHRJÄHRIGE VERWENDUNG