SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
A Robust Data-Mining Approach to Bankruptcy Prediction

In this study, new variants of genetic programming (GP), namely gene expression programming (GEP) and multi-expression programming (MEP), are utilized to build models for bankruptcy prediction. Generalized relationships are obtained to classify samples of 136 bankrupt and non-bankrupt Iranian corporations based on their financial ratios. An important contribution of this paper is to identify the effective predictive financial ratios on the basis of an extensive bankruptcy prediction literature review and upon a sequential feature selection analysis. The predictive performance of the GEP and MEP forecasting methods is compared with the performance of traditional statistical methods and a generalized regression neural network. The proposed GEP and MEP models are effectively capable of classifying bankrupt and non-bankrupt firms and outperform the models developed using other methods. Copyright © 2011 John Wiley & Sons, Ltd.
Scalar field cosmologies with inverted potentials

Regular bouncing solutions in the framework of a scalar-tensor gravity model were found in a recent work. We reconsider the problem in the Einstein frame (EF) in the present work. Singularities arising at the limit of physical viability of the model in the Jordan frame (JF) are either of the Big Bang or of the Big Crunch type in the EF. As a result we obtain integrable scalar field cosmological models in general relativity (GR) with inverted double-well potentials unbounded from below which possess solutions regular in the future, tending to a de Sitter space, and starting with a Big Bang. The existence of the two fixed points for the field dynamics at late times found earlier in the JF becomes transparent in the EF.
A SAFE ADJUSTABLE DOOR LOCK FOR CONTAINER DOORS

The invention relates to a door lock for a container door comprising a threaded claw shaft (10) having a first locking arm (12); a main body (20) having a second locking arm (24) corresponding to the first locking arm (12), an adjusting plug (50) provided on a distal end (14) of threaded claw shaft (10) and placed on the threaded claw shaft (10) in a rotating way as adjacent to the main body (20) in a manner to adjust the axial distance of the first locking arm (12) and the second locking arm (24). The main body (20) comprises a radially extending lock cylinder (30) locking the adjusting plug (50) and the threaded claw shaft (10) and a housing (22) formed on the main body (20) in a manner to at least partially surround the lock cylinder (30).
Propagation of atmospheric rossby waves - connection to predictability of climate extremes

Extreme weather events, such as heatwaves, droughts and flooding, have a devastating impact on humanity, causing increased mortality and suffering, as well as economic losses. Skillful predictions of such events, with sufficient lead-time for adaptation procedures can provide huge benefits to humankind. Recent extreme events, including the severe European and Russian heatwaves, have been found to be associated with particular atmospheric wave dynamics, specifically the propagation of Rossby waves along atmospheric waveguides. Our proposed research will explore the seasonal predictability of extreme events through a lens of atmospheric waveguides and Rossby wave propagation. We will answer four key research questions: 
I. What is the predictability of dominant modes of variability in waveguide geometry? 
II. How does the frequency of extreme events as a function of location relate to waveguide geometry in both observations and forecast systems?
III. How do the results from I and II combine to provide predictability on the likelihood of extreme events? 
IV. How does model resolution impact Rossby wave propagation and the relationship to extreme events?
Both re-analysis (observational) data, and seasonal forecast model data will be used. We will calculate the Rossby refractive index and analyze its spatial and temporal variability, quantifying the predictability in waveguide geometry. Extreme events (heatwaves, cold snaps, droughts and blocking events) will be identified in the datasets, with lag-lead regression and composites revealing the connections to the waveguide geometry. We will create empirical models to predict the frequency of extreme events, evaluate their reliability, and compare to these to existing dynamical forecasts. Our goal is to harness the increased understanding of climate extremes that atmospheric dynamics can bring, to help improve the predictability of extreme events, reducing their human and societal impacts.
Intelligent parkinson early detection guiding novel supportive interventions

Transition from healthy status to Parkinson’s Disease (PD) is vaguely tractable, since symptoms can be so subtle in the early stages that they go unnoticed. Lack of biomarkers and/or findings on routine MRI and CT scans, PD is left undiagnosed for years, gradually affecting the life of over 6.5 million of older adults (>55-60 yrs) worldwide, increasing the risk of their health deterioration. Epidemiological studies conclude that early intervention could have an inverse relation with the PD-related risks of progressive frailty, falls and emotional shift towards depression. Based on this evidence, the cardinal objective of i-PROGNOSIS is the development of (i) an ICT-based behavioural analysis approach for capturing, as early as possible, the PD symptoms appearance, and (ii) the application of ICT-based interventions countering identified risks. To achieve this, awareness initiatives will be employed, so as to construct i-PROGNOSIS community, targeting > 5000 older individuals within the duration of the project, in order to unobtrusively sense large scale behavioural data from its members, acquired from their natural use of mobile devices (smartphone/smartwatch). Ensuring anonymisation and secure Cloud archiving, i-PROGNOSIS will develop and employ advanced big data analytics and machine learning techniques, in a distributed and privacy aware fashion, so as to instantiate a PD Behavioural Model and construct reliable early PD symptoms detection alarms. To those identified and clinically validated as early stage PD patients, ICT-based interventions will be provided via the i-PROGNOSIS Intervention Platform, including: a) a Personalised Game Suite (ExerGames, DietaryGames, EmoGames, Handwriting/VoiceGames) for physical/emotional support, b) targeted nocturnal intervention to increase relaxation/sleep quality and c) assistive interventions for voice enhancement and gait rhythm guidance. In this way, i-PROGNOSIS will constructively contribute to active and healthy ageing.
CROSS-BORDER SUSTAINABLE PORTS

CSP project strategically serves the objective of the Greece –Italy ETC Programme for cross - border integrated sustainable connections. In particular the project focuses on infrastructural interventions in the Port of Bari and Corfu that will enhance goods’ and passengers’ transit along the ports . In the port of Bari such interventions comprise: - expansion of the the western dock extending out the dam and its outer pier via the construction of 2 piers and connected squares; - enhancement of the existing terminal with the creation of new surfaces and optimization of the existing area ; For P2: the Region of Ionian Islands the interventions refer to: - finalization and extension of construction works in the lee-wind dock of the Port of Corfu.
A Peculiar Alliance——Dunhuang Script S.2199 Ni Ling-hui's Promises Warrant

Dunhuang Script,S.2199 Ni Ling-hui's Promises Warrant,after having been checked and annotated by Liu Ming-shu and Shi Ping-ting,has drawn more attention from scholars.The Promises Warrant was a peculiar alliance among the civilians in ancient China.It showed its definite time,the law transaction,the testator's consciousness in the last stages and the feature of being quasi-official.The old people without children and heirs often used it when distributing their property.With the implementation of the new intestacy law in Song dynasty,the Promises Warrant in Tang and Five Dynasties died out.And the writer Ni Ling-hui was not a Buddhist nun,and also her surname was not bhiksuni,but an ordinary woman surnamed Ni.
Synthesis, characterization and quantum chemical study of optoelectronic nature of ferrocene derivatives

Two new ferrocene derivatives N-(2-hydroxy-5-methylphenyl) ferrocylideneamine (Fe1) and N-(2-hydroxy-5-chlorophenyl) ferrocylideneamine (Fe2) have been synthesized to study the effect on electronic, optical and charge transfer properties while changing the electron donating group with electron withdrawing group. The synthesized compounds were characterized by different spectroscopic (FTIR, UV–Vis, $$^{\mathrm {1}}\hbox {H NMR}$$
 , $$^{\mathrm {13}}\hbox {C NMR}$$
 ) and spectrometric (EI) techniques. The geometries for ground and excited states were optimized by density functional theory (DFT/B3lyp/6-31G**, LANL2DZ) and time-dependent DFT (TD-B3lyp/6-31G**, LANL2DZ) levels, respectively. The absorption, fluorescence and phosphorescence spectra were estimated using TD-B3LYP and TD-wB97XD functionals and 6-31G** basis set for C, H, N, O and LANL2DZ for Fe atoms in dichloromethane.
Owners of a common heritage. commons, environment and rights in european mountains (18th - 20th century)

The OCHER project investigates the relation between in-context historical forms of collective management of lands and resources and their current environmental and landscape value, triggering a reflection on the accessibility rights to natural resources for future generations.
Following the Habitats Directive, whose aim is to promote natural habitats taking account of local requirements, 8 sites in 4 different European countries, selected from the Natura 2000 list, are chosen as case studies in a comparative perspective. The research addresses different kinds of “institutions for collective action”, at different scales in rural areas. Here conservation and sustainable use of the environment are centred on ""people working with nature"" and minimal forms of organisation are mainly households. Therefore, a combined historical, anthropological and juridical approach is needed to achieve: 
•	a better understanding of the long-term effects and resilience of resource use in the environment; 
•	a deeper reflection on the specificity of collective subjects and on the mechanisms of collective legal actions and institutions. 
OCHER will also address the issue published by the Council of Europe in “Protecting future generations trough commons”, which features the project’s objective outlines with preeminent questions such as: 
•	What do we inherit from past generations from a cultural and environmental point of view? 
•	What is at stake in the environmental issues of the present? 
•	What can collective institutions teach us from an environmental perspective?
OCHER aims to contribute, with a multidisciplinary research, to the reflection on a new environmental right, that goes beyond the dichotomy man/nature, trying to understand the historical forms of a non-destructive, nor extractive, relation of interdependence in social and ecological systems. It also addresses the UN 2030 Agenda for Sustainable Development and intends to take action by means of its research outcomes
METHOD AND SYSTEM FOR RETRIEVING RISER FOR STORM EVACUATON

A method for preparing to move a floating structure away from a wellbore drilled below the bottom of a body of water includes filling a riser extending from the bottom of the body of water to the floating structure with water. The water in the riser is displaced to a selected first depth below the water surface. The riser is sealed at a second selected depth shallower than the first selected depth. The portion of the riser above the second selected depth is withdrawn onto the floating structure.
Apoyo a los procesos de toma de decisiones en Ndevr Sp. z o.o. a través de la compra de servicios de asesoramiento.

El objetivo específico del proyecto es examinar el concepto de obras de I+D previstas para una empresa basada en la tecnología de construcción de más energía adaptada a las condiciones climáticas polacas y a la legislación polaca en materia de construcción y a las necesidades de los clientes. El análisis previsto incluye actividades destinadas a crear y adquirir nuevos conocimientos sobre tecnologías innovadoras para el diseño de edificios residenciales o turísticos que utilicen fuentes de energía natural (energía solar, suelo térmico). El ámbito de trabajo incluirá la compra de servicios de asesoramiento.
Predictive modelling of gpcr druggable allosteric sites

G protein coupled-receptors (GPCRs) are the most successful class of druggable targets in the human genome with an estimated 30 to 60 % of prescription drugs in European Union. GPCRs biological state can be modulated by small molecule ligands acting on spatially distinct allosteric binding sites (ABSs) that result more selective and less toxic than drugs binding to orthosteric sites. The discovery of lead compounds targeting ABSs is challenging and to date has largely been achieved through cost-intensive and time-consuming high-throughput screening. The recent release of X-ray structures of GPCRs in the complex with allosteric modulators opens new opportunities to develop structure-based computer aided methodologies to identify ABSs.
MIDAS will aim to develop a computational methodology for the search of GPCR ABSs that will include cutting-edge enhanced sampling molecular dynamics simulation methods in cosolvent mapping. The action will solve several current limitations in cosolvent mapping: probe non-specific binding, protein denaturation, low probe sampling, and membrane distortion. MIDAS firstly develop the methodology in retrospective studies, aiming to identify ABSs in the M2, CRF1, P2Y and GCGR receptors for whom crystal structures complexed with allosteric modulators are available. The computational procedures will be developed for identification of extracellular and intracellular ABSs and ABSs at the interface between GPCR helices and lipids. Next, MIDAS will explore the developed protocols in prospective studies using the M3, µ-opipid and CCR5 receptors with available X-ray structures and known ligands. The action envisions the collaboration with experts from both academia and industry and is set to expand scientific, transferable and collaborative skills of the Experience Researcher. The outcome of the action will foster the development of novel health technologies for the discovery of safer drugs targeting membrane proteins.
Estratégia para o ensino do metabolismo dos carboidratos para o curso de farmácia, utilizando metodologia ativa de ensino

The traditional teaching method has been widely questioned on the development of skills and abilities in training healthcare professionals. In the traditional methodology the main transmitter of knowledge is the teacher while students assume passive spectator role. Some Brazilian institutions broke with this model, structuring the curriculum to student-centered learning. Some medical schools have adopted the Problem Based Learning (PBL), a methodology that presents problem questions, to be encountered by future physicians, for resolution in small tutorial groups. Our work proposes to apply an active teaching-learning methodology addressing carbohydrate metabolism during the discipline of biochemistry for under graduation students from pharmacy course. Thus, the academic content was presented through brief and objective talks. Later, learners were split into tutorial groups for the resolution of issues in context. During the activities, the teacher drove the discussion to the issues elucidation. At the end of the module learners evaluated the teaching methodology by means of an applied questionnaire and the developed content was evaluated by an usual individual test. The questionnaire analysis indicates that students believe they have actively participated in the teaching-learning process, being encouraged to discuss and understand the theme. The answers highlight closer ties between students and tutor. According to the professor, there is a greater student engagement with learning. It is concluded that an innovative methodology, where the primary responsibility for learning is centered in the student himself, besides to increase the interest in learning, facilitates learning by cases discussion in groups. The issues contextualization establishes a narrowing between theory and practice.
Reading descartes: a reassessment of the shaping and transmission of knowledge in the seventeenth century

The objective of this project is to provide the first in-depth study of the handwritten commentaries on the treatises of René Descartes. This study is important because such sources were crucial in shaping the intellectual revolution occurring in Europe during the 17th century, in which Descartes played a foremost role. However, we still do not have a complete grasp of why his ideas were so important to this revolution, because we do not know how his texts were closely read. The key to understand this process of reading and knowledge-building is the analysis of this kind of sources, up to now neglected by historians. Andrea Strazzoni has preliminarily ascertained their crucial role for the reception of Cartesianism while working on two monographs in the history of philosophy and science, making him the ideal researcher for this project. He has assessed the existence of 109 not retrieved items, plus 38 already retrieved ones. These commentaries constitute a body of literature whose complete analysis will be made possible by this project, focused on those authored by the first teachers of Cartesian ideas: Johannes de Raey and Johannes Clauberg. This study is now timely, because it benefits from new directions of investigation: (a) the study of reading and note-taking practices, (b) a transnational approach to the history of thought, (c) the application of digital mapping tools to large amounts of texts. Such approaches are now at the centre of new researches, led at Venice Ca’ Foscari by the applicant’s supervisor, Marco Sgarbi, and by Dirk van Miert at Utrecht, destination of a secondment. The project integrates these approaches in order to pursue its objective along three lines of investigation: (1) the search for uncatalogued handwritten sources, (2) their textual reconstruction and mapping, (3) the analysis of their use and dissemination. This project will enable Strazzoni to become a leading scholar in early modern philosophy, and to apply for a tenured position.
Abstract 8: APE1 Upregulation Reduces Oxidative DNA Damage and Protects Hippocampal Neurons from Ischemic Injury

Background and purpose: Apurinic/apyrimidinic endonuclease 1 (APE1) is a multifunctional enzyme that participates in base-excision repair of oxidative DNA damage and the redox activation of transcription factors. We tested the hypotheses that APE1 upregulation protects neuronal structure and function against transient global cerebral ischemia (tGCI). Methods: Transient GCI was induced for 12 min in male Sprague-Dawley rats with the 4-vessel occlusion method. Low-dose proton irradiation or transgenic overexpression was generated to upregulate APE1. Lentiviral vectors expressing shRNA against rat APE1 were stereotaxically infused in the dorsal hippocampus to knockdown APE1 expression. Golgi staining and immunofluorescence staining of synaptophysin-1 and PSD-95 were used to label dendritic spines and synapses. Field excitatory postsynaptic potentials in the Schaffer collateral pathway were measured to assess the hippocampal synaptic function. Morris water maze was performed 22-27 days after tGCI to assess the learning and memory deficits. Results: Upregulation of APE1 protected hippocampal CA1 neurons against tGCI-induced cell loss and reduced apurinic/apyrimidinic sites and DNA fragmentation. Conversely, APE1 knockdown attenuated irradiation-afforded protection. APE1 overexpression inhibited the DNA damage response, as evidenced by lower phospho-histone H2A (H2AX) and p53 upregulated modulator of apoptosis (PUMA) levels. APE1 overexpression also partially rescued CA1 dendritic spines after tGCI and attenuated the decrease in field excitatory postsynaptic potentials in the Schaffer collateral pathway. Presynaptic and postsynaptic markers were reduced following tGCI and this effect was also blunted in APE1 transgenics. The Morris water maze test revealed that APE1 protected against learning and memory deficits for at least 27 days post-injury. Animals expressing DNA repair-disabled mutant APE1 (D210A) exhibited more DNA damage than controls and were not protected against tGCI-induced cell loss. Conclusion: APE1 upregulation, either endogenously or through transgene overexpression, protects DNA, neuronal structures, synaptic function, and behavioral output from ischemic injury.
Response of tropical lower atmosphere to annular solar eclipse of 15 January, 2010

Abstract Special experiments were conducted at the time of annular solar eclipse of 15 January, 2010 from two tropical Indian stations Hyderabad and Gadanki to study changes in the lower atmosphere due to solar obscuration. A significant fall in temperature and ozone concentration has been observed below the tropopause with a rise in the lower stratosphere (18.5–20 km). Measurements show an increase in zonal wind velocity during eclipse. Meridional winds do not show appreciable changes. Very high frequency gravity waves close to Brunt Vaisala period are observed to be generated by the eclipse in the upper troposphere and lower stratosphere, which could be partially responsible for the reorganization of atmospheric species.
Grant for the company Mały-Bus Dariusz Jarosz for the financing of current operations

The project assumes a grant for the company Mały-Bus Dariusz Jarosz, which suffered as a result of the COVID-19 pandemic. Due to the pandemic, turnover fell by more than 70.51 %. The grant will ensure that the company’s activities and employment are maintained for a period of 3 calendar months.
Defining the mechanism of the dual spindle assembly and alignment in the mammalian zygote

The first embryonic division after fertilization is essential for development of the organism and has to promote the union of the parental genomes. My host lab recently showed that in mammalian zygotes two bipolar spindles form, which first independently congress the maternal and paternal chromosomes and then must be aligned in parallel for a faithful division. The novel dual spindle assembly provided a likely rationale for erroneous divisions into more than two blastomeric nuclei observed in human fertility treatment. Indeed, preventing the alignment of the two spindles gives rise to multi-nucleated two-cell embryos also in mice. Due to its recent discovery and the difficulty of imaging in the light sensitive zygote, dual spindle assembly and function remains elusive. It is for example unclear what the contribution of cytoplasmic versus chromosomal microtubule (MT) nucleation is for forming two spindles and why spindle alignment is error-prone and variable between different mammals. Recent advances in microscopy in my host lab now enable me to address these questions. In my project, I will dissect the mechanism of dual spindle assembly and function by combining light sheet microscopy, computational image analysis, and molecular perturbation. To achieve this, I will perform 4D imaging of live mouse zygotes at high resolution that allows me to track individual nucleation sites as well as MT tips. This will allow me to generate the first spatial map of MT nucleation and assess what the contribution of the two MT populations for dual spindle assembly is. Moreover, I will test which MT nucleation pathway is essential for dual spindle assembly by molecular perturbations. Finally, I will check if errors in spindle alignment are the cause of parental genome loss, by identifying the key alignment factors and validate them in model organisms with different alignment fidelities. Thus, my studies will improve our understanding of cell division in mammals and human infertility.