SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
The muscle protein synthetic response to food ingestion

Preservation of skeletal muscle mass is of great importance for maintaining both metabolic health and functional capacity. Muscle mass maintenance is regulated by the balance between muscle protein breakdown and synthesis rates. Both muscle protein breakdown and synthesis rates have been shown to be highly responsive to physical activity and food intake. Food intake, and protein ingestion in particular, directly stimulates muscle protein synthesis rates. The postprandial muscle protein synthetic response to feeding is regulated on a number of levels, including dietary protein digestion and amino acid absorption, splanchnic amino acid retention, postprandial insulin release, skeletal muscle tissue perfusion, amino acid uptake by muscle, and intramyocellular signaling. The postprandial muscle protein synthetic response to feeding is blunted in many conditions characterized by skeletal muscle loss, such as aging and muscle disuse. Therefore, it is important to define food characteristics that modulate postprandial muscle protein synthesis. Previous work has shown that the muscle protein synthetic response to feeding can be modulated by changing the amount of protein ingested, the source of dietary protein, as well as the timing of protein consumption. Most of this work has studied the postprandial response to the ingestion of isolated protein sources. Only few studies have investigated the postprandial muscle protein synthetic response to the ingestion of protein dense foods, such as dairy and meat. The current review will focus on the capacity of proteins and protein dense food products to stimulate postprandial muscle protein synthesis and identifies food characteristics that may modulate the anabolic properties.
Programme de développement des entreprises

Dans le cadre du programme de développement, l’entreprise prévoit d’étendre la production, de mettre de nouveaux produits et services sur le marché, d’accroître l’efficacité de la production et d’accroître les capacités de commercialisation.
Theoretical and Computational Investigation of Flagellin Translocation and Bacterial Flagellum Growth

The bacterial flagellum is a self-assembling filament, which bacteria use for swimming. It is built from tens of thousands of flagellin monomers in a self-assembly process that involves translocation of the monomers through the flagellar interior, a channel, to the growing tip. Flagellum monomers are pumped into the filament at the base, move unfolded along the channel and then bind to the tip of the filament, thereby extending the growing flagellum. The flagellin translocation process, due to the flagellum maximum length of 20 μm, is an extreme example of protein transport through channels. Here, we derive a model for flagellin transport through the long confining channel, testing the key assumptions of the model through molecular dynamics simulations that also furnish system parameters needed for quantitative description. Together, mathematical model and molecular dynamics simulations explain why the growth rate of flagellar filaments decays exponentially with filament length and why flagellum growth ceases at a certain maximum length.
CARACTERIZAÇÃO E OCORRÊNCIA DE CANDIDA EM PACIENTES SUBMETIDOS A TRATAMENTO ANTINEOPLÁSICO

Individuals with cancer are usually submitted to an tineoplastic chemotherapy during treatment. However, the dosage and frequency of use of these chemotherapeutic agents can result in severe oral complications t o the people involved, including Candida infections. The objective of this study was to defi ne the profile and assess fungal load from the oral mucosa of patients undergoing chemotherapy. A sample was collected from surface of the oral m ucosa of the patient and on the chromogenic medium. Most patients undergoing chemotherapy presents oral manifestati on, being the most prevalent xerostomia. Of the 30 patients sampl ed chemotherapy there was growth of Candida in 66.66%; and the
Retina organoid mechanobiology

The retina carries signatures of neuronal diseases which have been linked to mechanical abnormalities,
including Glaucoma and Alzheimer’s disease. Yet no biophysical retina model exists due to a cross-disciplinary
challenge: While stem cell derived organoids mimic the retina in vitro, organoid research has been
limited by large variations in cell and tissue organization. Mechanobiology, in turn, has revealed mechanical
signals as essential players in regulating cellular behavior to guide organogenesis. Accordingly, the ball is in
the court of physicists and bioengineers to quantify those mechanical signals and shape tissue growth by
tailoring the physical interactions of cells with their environment. Finally, the functionality of the retina has to
be quantified via neuroscience techniques. This multifaceted challenge has prevented the establishment of the
retina organoid as a biophysical model.
ROMB introduces a biophysical model for the retina which I will use to model Alzheimer’s disease in vitro.
It will be built on 4 cross-disciplinary posts: (i) retina organoids as a physiological in vitro model, (ii) tissue
mechanics measurements, (iii) neuronal activity readout and (iv) disease modeling. First, I will reveal the
mechanical building plan of retina organoids using ferrofluid droplets as mechanical actuators, hereby opening
the field of organoid mechanobiology. In a second step, the organoid’s 3D neuronal function will be recorded
using lightsheet microscopy. Mechanical, functional and genetic access will allow me in a final step to detect
and manipulate Alzheimer’s disease: using mouse retina organoids with a mutation in the App gene, I will
mechanically characterize the formation of those peptide aggregates which are the hallmark of disease onset.
ROMB opens the door to engineering functional retinas in vitro. Moreover, it will be uniquely suited to tackle
mechanically related neuronal diseases and promises a breakthrough for basic and applied research.
Framework for actual cooperation on energy on sites and parks

R-Aces means a step-change in the contribution of European Industry to the climate targets of the EU. The sector after all represents 25% of all energy demand – and 50% of all cooling and heating -  on the continent; yet only 16% comes from renewables. By focusing on collective measures and clustering, the efficiency of industry can be drastically increased.

The focus of R-Aces therefore is to turn high-potential, high-impact industrial clusters into EcoRegions that achieve at least a 10% reduction in emissions.  An Eco-region is an area where energy, material and information exchanges occur between various companies and actors to reduce waste and energy/material consumption. Each region is centered on an (eco-)industrial park or (eco-)business park, linked to its surroundings by a 4th/5th generation district heating/cooling network.

The consortium sees this project as a capping stone, condensing the knowledge and experience gathered throughout H2020 into a set of three focused tools embedded in selected support actions. The tools consist of an assessment tool; legal decision support for joint contracts; and a smart energy management platform for clusters. The support actions are built around peer-to-peer learning, more formal coursework and serious games.
Together they enable a cluster to really become an EcoRegion and set up meaningful energy collaboration.
The entire package of tools and support is aimed at the high-potential clusters identified in the European Thermal Roadmap. It will be validated in three of them (all are part of the consortium); actively deployed in another seven; and disseminated to ninety of them. In addition, the tools and support methodology will be made available to third parties in a sustainable way after the end of this two-year project.

The project consortium consists of the entire value chain needed for energy collaboration – suppliers, ESCO, cluster managers, support – and represents many years of proven experience in this field.
Internalisation of mattress production and entry into new markets with machines 4th generation

Internalisation of production of products with high added value, 3 new markets with strong impact of 4th generation investments (pavilion adaptation works, IoT, digitisation, remote operations, advanced data analysis and energy production for self-consumption) and hiring HR
Does the Quality of Fiscal Institutions Matter for Fiscal Performance? A Panel Data Analysis of European Countries

The last decade, the number of fiscal frameworks such as national fiscal rules and independent fiscal councils have increased, significantly as a consequence of fiscal indiscipline in many European Countries. In the wake of economic crisis in 2007, fiscal laxity and unsustainable public finances made the European Union to strengthen its fiscal policy in many ways in order to create an economic environment of macroeconomic stability and sustainable growth. This paper investigates the role of fiscal frameworks (fiscal rules and fiscal councils) on fiscal performance as well as the impact of other types of institutions, namely Worldwide Governance Indicators on primary balance. The empirical analysis builds on a reaction function proposed by Bohn (1998) while the estimation method builds on a fixed effect panel data estimation and a dynamic panel data estimation of Arellano-Bover and Blundell-Bond. Our main results provide that political stability, government effectiveness, fiscal rules and fiscal councils play an important role for improving fiscal performance. However, the effect of fiscal institutions on primary balance changes among different types of fiscal rules (debt rules, expenditure rules and budget balanced rules) and independent fiscal councils or fiscal councils that have access to information, respectively.
CONTROL OF RHEOLOGICAL PROPERTIES OF MIXED HYALURONATE/LUBRICIN SOLUTIONS

Disclosed are mixed solutions of PRG4 and hyaluronic acids having controlled, enhanced rheological properties adapted for various particular medical and cosmetic uses. Such solutions combine the solution-based lubrication ability of HA and the boundary -based lubricating effects of lubricin. Being more viscous, the solutions when used for joint viscosupplementation enhance both the duration of the HA within the joint capsule (in vivo halflife) and enhance the cushioning effects of the HA, as well as improve both solution and boundary mode lubrication mechanisms.
Cardio-metabolic risk factors and cortical thickness in a neurologically healthy male population: Results from the psychological, social and biological determinants of ill health (pSoBid) study

Cardio-metabolic risk factors have been associated with poor physical and mental health. Epidemiological studies have shown peripheral risk markers to be associated with poor cognitive functioning in normal healthy population and in disease. The aim of the study was to explore the relationship between cardio-metabolic risk factors and cortical thickness in a neurologically healthy middle aged population-based sample.T1-weighted MRI was used to create models of the cortex for calculation of regional cortical thickness in 40 adult males (average age = 50.96 years), selected from the pSoBid study. The relationship between cardio-vascular risk markers and cortical thickness across the whole brain, was examined using the general linear model. The relationship with various covariates of interest was explored.Lipid fractions with greater triglyceride content (TAG, VLDL and LDL) were associated with greater cortical thickness pertaining to a number of regions in the brain. Greater C reactive protein (CRP) and intercellular adhesion molecule (ICAM-1) levels were associated with cortical thinning pertaining to perisylvian regions in the left hemisphere. Smoking status and education status were significant covariates in the model.This exploratory study adds to a small body of existing literature increasingly showing a relationship between cardio-metabolic risk markers and regional cortical thickness involving a number of regions in the brain in a neurologically normal middle aged sample. A focused investigation of factors determining the inter-individual variations in regional cortical thickness in the adult brain could provide further clarity in our understanding of the relationship between cardio-metabolic factors and cortical structures.
Integrating innovative technologies along the value chain to improve small ruminant welfare management

TechCare is a multi-actor approach project aiming to develop appropriate business models using innovative technologies to improve welfare management for all EU small ruminant (SR) systems, to enable stakeholders to choose animal welfare-friendly products. SRs play a key socio-economic role in Europe, especially in harsh environments where innovative technology is not much implanted. SRs are often managed as a flock/herd, allowing only average welfare states to be considered. Innovative technologies are a unique opportunity to monitor and improve SR welfare management at the individual or flock/herd level, along the value chain. 
Based on SR welfare state-of-the-art, TechCare will undertake a multi-actor approach to encapsulate stakeholders’ expectations in terms of welfare and innovative technologies, and provide them with adapted solutions, in a co-design approach. TechCare will cover all stages of SR production and build novel welfare approaches to develop and validate tools, early warning systems, algorithms and indicators for efficient identification of welfare issues, including positive welfare, to include them in welfare management models. The innovative technologies identified in TechCare will pass different stages of validation, from prototyping to large scale studies. TechCare identified solutions will therefore be replicable and adapted to different SR systems, production purposes, and value chains, for improvement of SR welfare management EU-wide. 
Business models will be constructed and validated with stakeholders. Dissemination, communication and exploitation materials will be produced and widely shared for easy use of TechCare solutions, ensuring their uptake and relevance to all sectors and stakeholders. 
TechCare will offer a durable improvement of SR welfare management using innovative technologies along the whole value chain and across the EU, and will act as an example in terms of approach and solutions for other species and production systems.
APPUNTI PER UNA EDIZIONE DEL GLOSSARIO BERGAMASCO MEDIOEVALE DI ANTONIO TIRABOSCHI

Il presente contribuito descrive la struttura e i contenuti del Glossario Bergamasco Medioevale di Antonio Tiraboschi, attualmente conservato presso la Biblioteca Civica Angelo Mai di Bergamo, e costituito da quattro quaderni manoscritti e inediti, all’interno dei quali sono registrati oltre 2000 lemmi organizzati alfabeticamente. Si descrivono le fonti, edite e inedite, dalle quali Tiraboschi attinge i frammenti citati all’interno di ciascun lemma e si propone una classificazione delle annotazioni di cui il Glossario si compone in tre sottogruppi: &#x0D; &#x0D; note di carattere dialettologico, riguardanti gli esiti di forme latine o proto-romanze in italiano e nei dialetti gallo-italici (bergamasco, in primis) o relative alle particolari sfumature semantiche osservabili nel lessico del bergamasco;&#x0D; annotazioni di natura linguistica sulla comparsa di costruzioni romanze in sostituzione delle costruzioni latine, e sulle innovazioni semantiche romanze ravvisabili all’interno dei frammenti citati ad esemplificazione di ciascun lemma;&#x0D; osservazioni di carattere onomastico, relative a toponimi, microtoponimi e – più raramente – nomi personali.&#x0D; &#x0D; L’analisi condotta rappresenta un passo preliminare alla realizzazione di una edizione digitale (consultabile in modalità Open access a partire dalla home page della Biblioteca Civica Angelo Mai) dei preziosi materiali linguistici di cui il Glossario si compone e di una corrispondente edizione cartacea, che favoriscano valorizzazione e la fruizione del lavoro svolto dallo studioso bergamasco.&#x0D; &#x0D; Notes for an edition of Glossario Bergamasco Medioevale by Antonio Tiraboschi&#x0D; This paper describes the structure and the content of Antonio Tiraboschi's Glossario Bergamasco Medioevale, currently preserved at the Biblioteca Civica Angelo Mai in Bergamo, consisting of four manuscripts and unpublished notebooks containing more than 2000 alphabetically organized headwords. The sources, both published and unpublished, from which Tiraboschi drew the fragments cited as part of each lemma are described and a classification of the annotations into three subgroups is proposed: &#x0D; &#x0D; notes of a dialectological nature, concerning either Latin or proto-Roman forms in Italian as well as in the Gallo-Italic dialects (Bergamasque, in primis) or relating to particular semantic nuances observable in the lexicon of Bergamasque;&#x0D; linguistic notes on the appearance of Romance constructions replacing Latin constructions and questionable Romance semantic innovations in the fragments cited as examples of each lemma;&#x0D; onomastic observations, concerning toponyms, microtoponyms and - more rarely - personal names.&#x0D; &#x0D; This analysis is preliminary step towards creating a digital edition (available in Open access mode from the home page of the Biblioteca Civica Angelo Mai) of the precious linguistic materials which compose the Glossary and a corresponding paper edition, which will favor the valorization and fruition of the work carried out by the Bergamasque scholar.
From availability to uptake: planning for the introduction of new, child-friendly anti-tuberculosis formulations

Assessing the state of country readiness for the introduction of new, child-friendly anti-tuberculosis formulations can highlight potential bottlenecks, facilitate early planning, and accelerate access to appropriate treatment for children with tuberculosis (TB).To understand pathways and potential obstacles to the introduction of new pediatric formulations, we performed a desk review of key policy documents and conducted 146 stakeholder interviews in 19 high-burden countries.Issuance of World Health Organization (WHO) guidance serves as the trigger for considering adoption in most countries; however, the degree of alignment with WHO recommendations and duration of introduction processes vary. Endorsement by experts and availability of local evidence are leading criteria for adoption in upper-middle- and high-income countries. Ease of administration, decreased pill burden, and reduced treatment costs are prioritized in low- and lower-middle-income settings. Countries report an average of 10 steps on the path to new treatment introduction, with core steps taking between 18 and 71 months.The process of new treatment introduction is complicated by diverse country processes, adoption criteria, and evidence requirements. Challenges differ between low- and middle-to-high-income countries. Responsiveness to the unique hurdles faced across settings is important in ensuring a sustainable market for improved pediatric anti-tuberculosis treatment.
Contribution to control uncertainties in numerical modelling of dam performances : an application to an RCC dam

The use of fully probabilistic approaches to account for uncertainties within dam engineering is a recently emerging field on which studies have been mostly done concerning the safety evaluation of dams under service. This thesis arises within this framework as a contribution on moving the process of risk analysis of dams beyond empirical knowledge, applying probabilistic tools on the numerical modelling of a roller compacted concrete (RCC) dam during its construction phase.The work developed here aims to propose a methodology so as to account for risks related to cracking during construction which may compromise the dam’s functional and structural behaviour.In order to do so, emphasis is given to uncertainties related to the material itself (i.e.strength, water-to-cement ratio, among others) as well as to ambient conditions during the construction phase of RCC dams. A thermo-chemo-mechanical model is used to describe theRCC behaviour. Concerning the probabilistic model, two aspects are studied : how the uncertainties related to the input variables are propagated through the model, and what is the influence of their dispersion on the dispersion of the output, assessed by performing a global sensitivity analysis by means of the RBD-FAST method. Also, spatial variability of some input parameters is accounted for through bi-dimensional random fields. Furthermore, a coupling between reliability methods and finite element methods is performed in order to evaluate the cracking potential of each casted RCC layer during construction by means of a cracking density concept. As an important outcome of this applied research,probability curves for cracking density within each casted layer as functions of both age and boundary conditions are predicted, which is believed to be an original contribution of this thesis. The proposed methodology may therefore be seen as a contribution to help engineers understand how uncertainties will affect the dam behaviour during construction and rely on it inthe future to improve and support the design phase of the dam project.
Promoting citizens’ active involvement in the development of Sustainable Travel Plans in Med Cities with Seasonal Demand

MED cities although facing the common challenge of developing a sustainable mobility background, they also present particularities depending on the territorial context and the type of tourists they attract. For these reasons, a sound transnational approach, is the key to guarantee MOTIVATE’s success. Unlike the traditional data collection methods, where citizens or visitors are “passive” data sources, the innovative approach of MOTIVATE lies in their active involvement in transport data collection/management, problems identification and proposed measures evaluation. MOTIVATE promotes a new model of SUMP development. The new model is based on the exploitation of social media and crowd-sourcing apps. The common model of implementing and applying these techniques that will be created and updated after the pilot testing cases, as well as, the transferring protocol that will be created and will include, processes, techniques and tools to ensure the efficient and consistent way of transferring the projects' results to other cities, will support the SUMP development and enhancement in all the Med area. MOTIVATE intends to help decision makers to gain a strong understanding of the main mobility problems that residents and tourists face and the most accepted and sustainable interventions, using cost effective ways of data collection and analysis and this will make the development, update and monitoring of SUMP much more targeted and efficient.