SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
A revolutionary, safe and cost-effective industrial process for gluten detoxification in cereals

Led by inventor Carmen Lamacchia, New Gluten World (NGW) is a company that aims at bringing on the market its
revolutionary proprietary technology that will be used in milling processes to detoxify gluten in wheat. The traditional
approach to celiac disease – that is, a “gluten free” diet or detoxified gluten with expensive enzymes – will be replaced by a
new, disruptive and cost-effective approach, where a natural and safe physic-chemical process modifies the toxic
component of gluten, while leaving its mechanical, nutritional, and sensorial properties. Celiac, intolerant, and glutensensitive
patients will have the chance of a new lifestyle, without suffering the “nutritional divide” with respect to healthy
individuals. The methodology stems from the advanced biotech research conducted at the University of Foggia and
addresses a grand social and economic challenge for Europe and for the world, where celiac patients are on average 1% of
the world population, while 30% has gluten-sensitivity, with figures increasing every year.
Thanks to a strong team, with industrial and technological expertise, NGW will enable milling companies (mostly SMEs) in
Europe and abroad to adopt the process technology and related know-how, thus reinforcing the well-known leadership of the
European agro-food industry in terms of quality, as opposed to intensive productions by other economic systems. The
market opportunity is huge, fenced by a patent extended in 104 countries. Such opportunity will be seized by NGW moving
from TRL #6 to TRL #8 and #9 in a 24-month time-span. Aiming to become the market leader for industrial processes in
detoxifying gluten in cereals for all markets (backed products, pasta, ice-creams, beer), NGW plans to reach a turnover of
over 100M€ by 2022, with an ambitious hiring plan of qualified workers in Europe.
NGW received the prestigious NutriAward (2015) and a manifestation of interest from a leading European venture capital
firm that will support its growth.
Lifelong learning is central to the practice of public relations and communications management

Remarks by Maria P. Russell, delivered on Saturday, October 18, 2014 at the Autumn Gala Dinner of the Master of Communications Management program, which is offered in partnership between McMaster and Syracuse Universities. Russell was the founder of the Master of Science of Communications Management at the Newhouse School of Public Communications at Syracuse Uniersity and has been its director for twenty years. The author discusses her long career in public relations, as a practitioner, academic and active professional association member. She discusses five trends that Richard Edelman, chairman of Edelman Public Relations has put forward. Russell finishes the speech with a quote from Ann Lamott  ©Journal of Professional Communication, all rights reserved.
On the Riemann problem for supercritical CO 2 injection into an aquifer

Abstract The classical self-similar Riemann problem is considered for the process of supercritical CO2 injection into a permeable reservoir saturated by water. In an asymptotic approximation, the solution of the problem is constructed using the equations for nonisothermal multiphase flows in a porous medium. The qualitatively different solutions are determined depending on initial reservoir temperature and injection parameters. The wave pattern propagating from CO2 injection well in the aquifer consists of up to six nonlinear rarefaction (simple) waves and shock waves (phase discontinuities). The influence of the pressure increase around CO2 injection well on the wave pattern is investigated. The accuracy of the asymptotic solution is evaluated by its comparison with the results of direct numerical simulations.
Evaluation of the effect of arterial input function on cerebral blood flow in MR perfusion imaging

Cerebral blood flow (CBF) calculation in perfusion weighted imaging starts with the selection of arterial input function (AIF). CBF indicates the initial value of the tissue residue function found by deconvolving the tissue perfusion curve with the AIF. Conventional approach of CBF calculation by deconvolution is singular value decomposition (SVD) method. This technique is not successful if the problem is ill-posed, which is the case when the singular values of the solution decrease rapidly. The ill-posed nature of the problem is generally resolved through the model independent method based on Tikhonov regularization. In this method, optimum value of the regularization parameter is selected either according to the L-curve criterion, LCC, or by the generalized cross validation method, GCV. In this study, besides Tikhonov regularization, a more deterministic method, state space model fitting was employed as an alternative approach and CBF values were found in well agreement with those found by Tikhonov regularization. AIF is delayed and dispersed during the transition from the major artery to the small arterial branches feeding the tissue. Since delay compensation is possible by time shifting, we focused on dispersion in this study. To be able to analyze the effects of dispersion on CBF computation, time curves of AIF and the tissue response were simulated. Different levels of dispersion were produced resulting in AIFs that simulate the transition from arteries to arterial branches at distant locations of the brain. The results of the simulation studies indicate that, if ignored, dispersion might result in underestimated CBF.
Laboratory evolution of virus-like protein cages for eukaryotic mrna delivery

Nucleic acids are promising candidates for treating disease by stimulating, inhibiting, or replacing other nucleic acids or proteins inside of eukaryotic cells—a process known as “gene therapy.” However, methods to efficiently and safely deliver genes into cells are still lacking. The problem is that nucleic acids are not cell permeant and degrade before reaching the cytosol. One way to transport oligonucleotides into cells is by packaging them into hollow containers made of proteins, a method that has been successfully hijacked by viruses for a long time.

Here, we propose to design and engineer an artificial proteinaceous container that (1) selectively encapsulates ribonucleic acids (RNAs) using a known RNA recognition tag and (2) delivers this RNA into the cytosol of mammalian cells. Protein engineering, which embodies both rational design and computational modeling, will be used to create the starting design of this artificial protein container. The initial design will be based on the protein lumazine synthase from the bacterial organism Aquifex aeolicus (AaLS), which forms small but highly symmetrical nanocompartments in bacteria and is very tolerant to genetic changes. To optimize this design, we will use directed evolution to induce an artificial selection pressure on a large population of distinct capsid variants, allowing us to obtain only the best-performing capsid variants: those that can enter and disassemble selectively inside of mammalian cells, thereby releasing the enclosed RNA molecules into the cytosol. New AaLS containers will be thoroughly characterized using cutting-edge technologies, such next-generation sequencing and cryo-electron microscopy.

The ultimate goal of LEVERAGE mRNA is to use the designed and evolved capsids to deliver messenger RNAs (mRNAs) into cells that encode missing or dysfunctional proteins, for example in enzyme replacement therapies. If successful, this action will have lasting positive impacts on human health.
Predicting hydration free energies with a hybrid QM/MM approach: an evaluation of implicit and explicit solvation models in SAMPL4

The correct representation of solute-water interactions is essential for the accurate simulation of most biological phenomena. Several highly accurate quantum methods are available to deal with solvation by using both implicit and explicit solvents. So far, however, most evaluations of those methods were based on a single conformation, which neglects solute entropy. Here, we present the first test of a novel approach to determine hydration free energies that uses molecular mechanics (MM) to sample phase space and quantum mechanics (QM) to evaluate the potential energies. Free energies are determined by using re-weighting with the Non-Boltzmann Bennett (NBB) method. In this context, the method is referred to as QM-NBB. Based on snapshots from MM sampling and accounting for their correct Boltzmann weight, it is possible to obtain hydration free energies that incorporate the effect of solute entropy. We evaluate the performance of several QM implicit solvent models, as well as explicit solvent QM/MM for the blind subset of the SAMPL4 hydration free energy challenge. While classical free energy simulations with molecular dynamics give root mean square deviations (RMSD) of 2.8 and 2.3 kcal/mol, the hybrid approach yields an improved RMSD of 1.6 kcal/mol. By selecting an appropriate functional and basis set, the RMSD can be reduced to 1 kcal/mol for calculations based on a single conformation. Results for a selected set of challenging molecules imply that this RMSD can be further reduced by using NBB to reweight MM trajectories with the SMD implicit solvent model.
WELL & FIT SOCIETA' SPORTIVA DILETTANTISTICA A RESPONSABILITA' LIMITATA

LA PALESTRA WELL & FIT ORGANIZZA CORSI PER BENESSERE FISICO, GINNASTICA VERTEBRALE, GINNASTICA POSTURALE, PILATES PER ANZIANI, LEZIONI PRIVATE CON PERSONAL TRAINER ANCHE PER SOGGETTI CON DISABILITA' E LE PIU' SVARIATE ATTIVITA' LEGATE SIA AL MONDO DEI PIU' GIOVANI CHE DEGLI ADULTI. L'ASSOCIAZIONE WELL & FIT COLLABORA ED E' CONVENZIONATA CON L'ASSOCIAZIONE 'CUORE IN FORMA' CHE SVOLGE ATTIVITA' DI SUPPORTO PER PERSONE CARDIOPATICHE. L'ORGANIZZAZIONE 'CUORE IN FORMA' NON HA FINI DI LUCRO, SI AVVALE IN MODO DETERMINANTE DELLE PRESTAZIONI PERSONALI VOLONTARIE E GRATUITE DEI PROPRI ADERENTI. L'ORGANIZZAZIONE PERSEGUE FINI DI SOLIDARIETA' SOCIALE E DI ASSISTENZA SOCIO-SANITARIA E SI OCCUPA IN PARTICOLARE DI ATTIVITA' NEL CAMPO DELLA PREVENZIONE E RIABILITAZIONE DELLE MALATTIE CARDIOVASCOLARI, PROMUOVENDO L'INFORMAZIONE E LA SENSIBILIZZAZIONE, PARTECIPANDO A PROGRAMMI E PROGETTI SCIENTIFICI, PROMUOVENDO LA RICERCA, ASSISTENDO E SUPPORTANDO I CENTRI DI PREVENZIONE E RIABILITAZIONE, COMBATTEN
Efficient diagnosis of grate-fired biomass boilers by a simplified CFD-based approach

Abstract This paper describes the development and validation of a numerical tool able to simulate biomass combustion in grate-fired systems and support operation and design improvements of these devices. The modeling method is conceived as a compromise between the demand of computing time and the degree of detail in the simulation. As such, it integrates both the bed zone and the freeboard zone on a same 3D grid and assumes the bed as a porous medium, where heterogeneous reactions are simulated by a modified laminar rate model. Liquid water, dry biomass and char are introduced as site species that react on the porous medium surfaces to produce and/or consume gas species (O2, CO, CO2, H2, H2O, light hydrocarbons and condensable gases). To validate the numerical tool, predictions have been compared to experimental data gathered in a 250 kWth combustion test facility operated with a high quality woody pellet. Once validated, the tool has been applied to characterize the flow patterns as well as the temperature and the main gaseous emissions profiles within the combustion chamber. According to the analysis of the simulation results, significant improvements have been identified concerning not only operation but also design issues.
High-Frequency spin entanglement generation in diamond

This proposal promotes a research program in quantum nano-photonics to be carried out by dr T. Jakubczyk. It aimes at achieving high frequency of generation and detection of spin-spin entanglement in spatially separated nitrogen vacancy (NV) centers in diamond. While current photon collection efficiencies (few per cent) and entanglement rates (approx. one entanglement event per minute) may be sufficient for proof-of-principle experiments, they need to be greatly improved for the implementation of practical quantum networks.
The project builts on a recent progress achieved in the host institution in the deterministic cavity-assisted enhancement of the coherent photon emission rate of NV centers embedded in a diamond membrane. The increase of the decay rate results in enhanced radiative efficiency and makes the emission robust against dephasing enhancing the photon indistinguishability and boosting the photon extraction efficiency. The aim of the project is to establish the NV center as spin- and optically- coherent, specifically by decreasing the linewidth broadening resulting from the minimal necessary processing of the diamond crystal and introducing significant improvements to the cavity.  The estimated resulting spin-spin entanglement rates are in the Mhz-range. 
The projects opens new ways of studying complex and non-trivial phenomena resulting from the enhanced light-matter coupling in the NV center and in other quantum emitters. Success of this project may provide a route to the realisation of scalable quantum computers based on optical networks of electronic and nuclear spins.
Comparative Theoretical Studies of Energetic Azo s-Triazines

In this work, the properties of the synthesized high-nitrogen compounds 4,4',6,6'-tetra(azido)azo-1,3,5-triazine (TAAT) and 4,4',6,6'-tetra(azido)hydrazo-1,3,5-triazine (TAHT), and a set of designed bridged triazines with similar bridges were studied theoretically to facilitate further developments for the molecules of interests. The gas-phase heats of formation were predicted based on the isodesmic reactions by using the DFT-B3LYP/AUG-cc-PVDZ method. The estimates of the condensed-phase heats of formation and heats of sublimation were estimated in the framework of the Politzer approach. Calculation results show that the method gives a good estimation for enthalpies, in comparison with available experimental data for TAAT and TAHT. The crystal density has been computed using molecular packing calculations. The calculated detonation velocities and detonation pressures indicate that -NF(2), -NO(2), -N═N-, and -N═N(O)- groups are effective structural units for improving the detonation performance of the bridged triazines. The synthesized TAAT and TAHT are not preferred energetic materials due to their inferior detonation performance. The p→π conjugation effect between the triazine rings and bridges makes the molecule stable as a whole. The electrostatic behavior of the bridged triazines is characterized by an anomalous surface potential imbalance when incorporating the strongly electron-withdrawing -NF(2) and -NO(2) groups into the molecule. An analysis of the bond dissociation energies shows that all these derivatives have good thermal stability over RDX and HMX, and the -NH-NH- bridge is more helpful for improving the stability than -N═N(O)- and -N═N- bridges. Considering the detonation performance and thermal stability, three bridged triazines may be considered as the potential candidates of high-energy density materials (HEDMs).
Radioisotopes: An overview

Many elements which found on earth exist in different atomic configurations and are termed isotopes which have same atomic number but differ in their atomic mass. these unstable element decay by emission of energy such isotopes, which emit radiation, are called radioisotopes. Using of these isotopes in various sectors like industries, agriculture, healthcare and research centres has got a great importance at present. In health care sector, these isotopes are used in nuclear medicine as diagnostic and therapeutic modalities. radionuclide imaging (or functional imaging) is a branch of medicine which provides the only means of assessing physiologic changes that is a direct result of biochemical alterations and is based on the radiotracer method. In nuclear medicine procedures, radionuclides are combined with other chemical compounds or pharmaceuticals to form radiopharmaceuticals. these radiopharmaceuticals, once administered to the patient, can localize to specific organs or cellular receptors. this unique ability of radiopharmaceuticals allows nuclear medicine
Examining the Relationship Between Schizotypy and Self-Reported Visual Imagery Vividness in Grapheme-Color Synaesthesia

Synaesthesia is a condition in which one property of a stimulus triggers a secondary experience not typically associated with the first (e.g., seeing achromatic graphemes can evoke the perception of color). Recent work has explored a variety of cognitive and perceptual traits associated with synaesthesia. One example is in the domain of personality, where higher rates of positive schizotypy and openness to experience and lower agreeableness have been reported in synaesthetes who experience color as their evoked sensation relative to typical adult controls. Additionally, grapheme-color synaesthetes have previously been reported to show elevated mental imagery compared to typical adults. Here, we aimed to further elucidate the relationship between personality, synaesthesia, and other cognitive traits. In Study 1, we examined self-reported schizotypy and self-reported visual imagery vividness in grapheme-color synaesthetes and typical adults. Our results partially replicated previous findings by showing that synaesthesia was associated with greater positive schizotypy and enhanced self-reported imagery vividness. The results also extend previous reports by demonstrating that differences in positive schizotypy and mental imagery vividness are not related in grapheme-color synaesthesia. In Study 2, we sought to build on prior work showing lower agreeableness and increased openness to experience in synaesthetes by examining whether grapheme-color synaesthesia is associated with other conceptually related traits; namely lower self-monitoring and increased sensation seeking. We did not find any differences between synaesthetes and controls on either of these traits. These findings are discussed in relation to potential factors that may contribute to the observed personality profile in grapheme-color synaesthesia.
O fenômeno da viralização: o caso da moda feminina no Brasil

Objetivo – Um dos maiores desafios empresariais é entender o fenômeno da viralização, que acontece quando determinados produtos se espalham rapidamente entre os estratos sociais, são adotados pela maioria e perdem força logo em seguida. A importância deste estudo está no impacto econômico da viralização do marketing na moda feminina. O objetivo principal desta pesquisa é compreender como se relacionam os principais fatores responsáveis pela viralização de produtos de moda. Metodologia – Trata-se de uma pesquisa qualitativa e descritiva, baseada no método de estudo de caso setorial. Os dados primários foram coletados por meio de entrevistas em profundidade com especialistas do mercado. A análise de conteúdo foi realizada por meio da técnica de codificação em três níveis (aberta, axial e teórica), com auxílio do software Atlas.TI. Resultados – Os principais resultados da pesquisa indicam que a viralização ocorre quando os seguintes fatores estão relacionados: atributos funcionais e emocionais do produto, difusores, comunicação, estratégia de marca e comportamento do consumidor. No caso da moda feminina, a previsão de tendências é importante para o desenvolvimento das coleções. Representa a forma da empresa estar à frente do consumidor e produzir as peças para atender às suas necessidades. Limitações – A limitação está relacionada à amostra. Apesar de serem especialistas no setor da moda, por falta de tempo e recursos, os grupos de consumidores não foram incluídos na pesquisa. Originalidade – A principal contribuição acadêmica do estudo é a proposição de um modelo teórico que explique o fenômeno da viralização no caso setorial estudado.
Mechanisms of auxin-dependent signaling in the endoplasmic reticulum

The phytohormone auxin has profound importance for plant development. The extracellular AUXIN BINDING PROTEIN1 (ABP1) and the nuclear AUXIN F-BOX PROTEINs (TIR1/AFBs) auxin receptors perceive fast, non-genomic and slow, genomic auxin responses, respectively. Despite the fact that ABP1 mainly localizes to the endoplasmic reticulum (ER), until now it has been proposed to be active only in the extracellular matrix (reviewed in Sauer and Kleine-Vehn, 2011). Just recently, ABP1 function was also linked to genomic responses, modulating TIR1/AFB-dependent processes (Tromas et al., 2013). Intriguingly, the genomic effect of ABP1 appears to be at least partially independent of the endogenous auxin indole 3-acetic acid (IAA) (Paque et al., 2014). 
 In this proposal my main research objective is to unravel the importance of the ER for genomic auxin responses. The PIN-LIKES (PILS) putative carriers for auxinic compounds also localize to the ER and determine the cellular sensitivity to auxin. PILS5 gain-of-function reduces canonical auxin signaling (Barbez et al., 2012) and phenocopies abp1 knock down lines (Barbez et al., 2012, Paque et al., 2014). Accordingly, a PILS-dependent substrate could be a negative regulator of ABP1 function in the ER. Based on our unpublished data, an IAA metabolite could play a role in ABP1-dependent processes in the ER, possibly providing feedback on the canonical nuclear IAA-signaling. 
 I hypothesize that the genomic auxin response may be an integration of auxin- and auxin-metabolite-dependent nuclear and ER localized signaling, respectively. This proposed project aims to characterize a novel auxin-signaling paradigm in plants. We will employ state of the art interdisciplinary (biochemical, biophysical, computational modeling, molecular, and genetic) methods to assess the projected research. The identification of the proposed auxin conjugate-dependent signal could have far reaching plant developmental and biotechnological importance.
Recording tape cartridge

A recording tape cartridge (10) can prevent release of rotation locking of a reel (40) with respect to a case accompanying dropping of the recording tape cartridge. The tape recording cartridge is configured to rotatably accommodate within a case a reel that has magnetic tape wound on a reel hub. Within the reel hub, external teeth of a brake gear (82), of a brake member (80) that is supported so as to be non-rotatable with respect to the case, mesh with an engaged gear (54) having internal teeth, preventing rotation of the reel with respect to the case. Lock portions (93) of lock members (90) are inserted between the reel positioned biased to a bottom panel side by a compression coil spring (78), and a top panel, thereby preventing movement of the reel with respect to the case in the reel axial direction.
Human capital and performance in young audit firms

Abstract This research analyzes the relationship between auditors' human capital attributes and young audit firms' performance. The study applies fuzzy-set qualitative comparative analysis (fsQCA) to a sample of 26 young Portuguese audit firms. The results reveal the existence of multiple combinations of human capital attributes leading to high performance, thus supporting the relevance of the human capital in the audit industry and highlighting the importance of human capital attributes toward the performance of young audit firms. These findings can help auditors–entrepreneurs invest in the development of those human capital attributes that are pertinent to succeed in the marketplace. The use of fsQCA enables the identification of alternative combinations of human capital attributes that associate with higher performance, which constitutes an important contribution to the literature.