SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
CLOSING CYLINDER, ESPECIALLY FOR VEHICLES

The invention relates to a closing cylinder comprised of a cylinder core (10) which is rotationally accommodated in a cylinder housing (20), and which has a profiled axial boring (11). An axially parallel roll body (25) is arranged in said closing cylinder and is always guided with a partial cross-section (26) in a radial opening (14) of the cylinder core. According to whether an initial position of rotation or a key rotation exists, the blocking element (25) either runs into an inner groove (24) of the cylinder housing (20) or into a marginal recess (34) of a group of rotating discs (30) which are arranged in a profiled axial boring (11) of the cylinder core (10). In order to increase the useful life of the closing cylinder, the invention provides that a spring element (50; 28, 50') is arranged at least between one of the rotating discs (30) and the cylinder core (10). The spring load resulting therefrom blocks, via a blocking surface provided on the rotating disc (30), the blocking element (25) in the cylinder housing (20) in a manner which prevents rotation. The cylinder core (10) comprises, with the axial section thereof serving to accommodate the rotating discs (30), a radial recess (12; 12') for the spring element, and the recess (12', 12') is connected via a radial slot (54) to the axial boring (11) of the cylinder core (10) which accommodates the rotating discs (30).
Changes of co2 levels during past and future interglacials

The concentration of carbon dioxide (CO2) in the atmosphere depends on carbon cycle processes, i.e. sources and sinks of carbon. The future evolution of the carbon sinks is not well known, which inhibits robust quantification of future atmospheric CO2 concentration and the resulting climate change. Understanding warm past periods is essential to constrain climate models and accurately predict future changes. During the last million years, warmer periods, called interglacials, happened every ~100,000 years. CO2 levels measured in interglacials before the mid-Bruhnes event (MBE), a large climate shift taking place ~430,000 years ago, are lower than the CO2 in interglacials after the MBE. The cause for this drastic evolution is still unexplained, resulting in uncertainty in the carbon cycle response to global warming.
To resolve that issue, we propose to combine data and model simulations including new key processes. We suggest that a major mechanism was a slower circulation during interglacials before the MBE, resulting in more ocean carbon storage and lower atmospheric CO2. We also hypothesize that sea-level changes played a considerable role by altering carbon sinks from land vegetation and shallowing ocean carbonate sedimentation. We will include these mechanisms in a state-of-the-art climate model applicable to long timescales, and compare its modified behaviour with paleoclimate data and more complex models used for projections. This will provide a step change in our understanding of the impact of ocean circulation and sea-level changes on the carbon cycle. It will benefit the European and international scientific community by shedding new light on these processes, and by setting the basis to include these new mechanisms in climate models used for projections. The excellence of the experienced researcher in carbon cycle modelling combined with the expertise in ocean modelling and paleoclimate data from the host institution will ensure the success of this project.
Establishing how bacterial cells position the division site

In virtually all bacteria cell division is essential and tightly regulated both temporally
and spatially to ensure that cells divide precisely at the centre between segregated
chromosomes. Failure to do so can lead to cell death. The earliest event in bacterial cell
division is the polymerization of the highly conserved tubulin-like protein, FtsZ, to
form a contractile structure called the Z ring, on the inner side of the cytoplasmic
membrane at midcell and between chromosomes. The Z ring subsequently contracts
causing the cell envelope to invaginate, generating two newborn cells. Thus the Z ring
defines the position of the division site in bacterial cells.
How the Z ring is positioned precisely at midcell is a controversial topic that remains
unresolved. Division site positioning has long been believed to occur via the combined
action of two factors: the Min system and nucleoid occlusion. Both factors have been
proposed to prevent Z ring assembly along the length of the cell, allowing it to
assemble only once chromosomes segregate and nucleoid occlusion is relieved
specifically at midcell. The research described in this thesis challenges this paradigm,
providing compelling evidence that other mechanisms in addition to nucleoid occlusion
and the Min system act to position the Z ring at midcell in B. subtilis. Moreover, this
work also shows that nucleoid occlusion and the Min system do not define the Z ring
position at midcell but rather ensure that the midcell division site is utilized efficiently.
A clue to an additional mechanism for positioning the Z ring has emerged from studies
investigating the relationship between chromosome replication and Z ring position. The
nature of this relationship has remained obscure for years. Part of this thesis involves a
closer examination of this relationship. It was found that the ability to position the Z
ring at midcell is linked specifically to the progress of the initiation stage of DNA
replication, such that the frequency of Z rings at midcell increases as this stage of DNA
replication is progressively completed. Moreover, this link was found to be nucleoid
occlusion independent.
Spatial and temporal control of Z ring assembly has been widely attributed to the Min
system and nucleoid occlusion. While inactivating both systems substantially affects
cell division, it is currently unknown whether their absence affects precise midcell Z
ring positioning. This thesis deals with this question, and it was found that the
combined effect of MinCD and Noc proteins actually affects the timing and efficiency
of Z ring assembly, but not its spatial precision between nucleoids at midcell.
If Noc and MinCD proteins do not position the Z ring at midcell, what other factores
may play this role? Two hypotheses were proposed to help explain the precise Z ring
positioning observed in absence of nae and minCD: 1) Noc-independent nucleoid
occlusion or 2) factors completely independent of nucleoid occlusion position the Z
ring at midcell. Experiments designed…
Subvención de capital de trabajo — Studio Makijażu Ohana Joanna Starnawska

El proyecto se refiere al apoyo al capital circulante de una empresa en caso de disminución del volumen de negocios (ingresos procedentes de las ventas) causado por los efectos negativos del brote de COVID-19.
[Ki-67 expression in stage III cervical squamous cell carcinoma and its correlation with sensitivity to chemoradiotherapy].

To investigate the expression of proliferating cell nuclear antigen (Ki-67) in stage III cervical squamous cell carcinoma (SCC) and its correlation with the effect of chemotherapy on sensitivity to radiotherapy.In 50 patients with stage III cervical squamous cell carcinoma (SCC), 25 patients were treated with radiotherapy and 25 patients were treated with chemoradiotherapy. The expression of Ki-67 in the biopsy specimens of cervical SCC was detected by immunohistochemistry at diagnosis and after 10 Gy radiotherapy. The correlation of Ki-67 positive cells percentage and chemotherapy with sensitivity to radiotherapy was analyzed.In 25 patients with more than 48% Ki-67 positive cells at diagnosis, the rate of complete response (CR) was 72.0% (18/25). In 25 patients with less than 48% Ki-67 positive cells at diagnosis, the CR rate was 40.0% (10/25), with a significant difference between them (P = 0.023). In 26 patients with more than 31% decrease of Ki-67 positive cells after 10 Gy radiotherapy, the CR rate was 84.6% (22/26). In 24 patients with less than 31% decrease of Ki-67 positive cells after 10 Gy radiotherapy, the CR rate was 25.0% (6/24), showing a significant difference between the two groups (P < 0.001). In the cases of Ki-67<48%, decrease of Ki-67 positive cells of chemoradiotherapy group after 10 Gy radiotherapy was significantly higher than that of the radiotherapy group (P = 0.023). In the cases of Ki-67 ≥ 48%, no difference in the decease of Ki-67 positive cells between the chemoradiotherapy and radiotherapy groups was found (P = 0.173). For the radiotherapy-sensitive patients with CR recently, the 2-year progression free survival (PFS) rate and overall survival (OS) rate were 85.7% and 92.9%, respectively, both were significantly higher than those of radiotherapy-insensitive patients (18.2% and 40.9%, P < 0.05 for both).In stage III cervical SCC, the expression of Ki-67 before and after treatment with 10 Gy radiotherapy may be used as a biomarker to predict tumor response to radiation, and guide the choice of therapeutic strategies. Yet, the effect of chemotherapy as a radiosensitizer is unconspicuous.
Toxin mimetics of human peptides as novel tools for drug discovery and design

Venomous animals use a myriad of toxins to specifically disrupt the physiology and behavior of their prey. Because of their high stability, potency, and specificity, toxins are important tools for biomedical research and have been developed as therapeutics for various human diseases. However, contributions to date pale in comparison to future prospects. We hypothesize that a small and essentially overlooked group of toxins, “ToxMims”, represent the most promising candidates for drug discovery and development. ToxMims potently disrupt the prey’s physiology by specifically mimicking the action of endogenous signaling peptides. Because many of these signaling peptides are critical players in human health and disease, ToxMims are exceptionally promising drug leads. Proof-of-concept is provided by our recent discovery of a toxin mimetic of insulin that is used by a marine cone snail to induce dangerously low blood sugar in fish prey. Because of its advantageous properties over human insulin, the venom insulin has rapidly become a novel drug lead for the treatment of diabetes. Despite their significant biomedical potential, ToxMims are rare and difficult to systematically detect using currently available methodologies. By leveraging recent advances in next-generation sequencing combined with our proven expertise in computational and experimental venom discovery and pharmacology, this project aims to develop a set of tools to enable the systematic identification and characterization of any ToxMim of the ~350 human signaling peptides with an emphasis on those implicated in disease. If successful, this research will not only identify a set of unique drug leads with profound impact on human health but elucidate previously unknown mechanisms of receptor activation, inhibition and signaling. Furthermore, this project will foster European excellence in venom research and develop scientific leadership competences for an independent, early-career researcher returning to Europe.
New species, new combination, and a revised key to species of <i>Eburella</i> Monné &amp; Martins (Coleoptera: Cerambycidae: Eburiini)

SummaryEburella crucena n. sp. is described from Bolivia. Beraba cauera Galileo & Martins, 1999 is transferred to Eburella Monné & Martins, 1973, with a new state record for Pará (Brazil). An updated key to species of Eburella is provided.
PROCESS FOR DETERMINING THE CONVEYOR POWER OF A CONVEYOR-BELT WEIGHER AND A DEVICE FOR CARRYING THIS OUT

In order to improve the accuracy of conveyor-belt weighers, in particular dosing belt weighers, a process for determining the conveyor power is proposed whereby at least two weighing cells (5, 6) are provided with a predetermined distance (D) between them, their weighing signal curves (5b, 6b) being compared taking into a ccount the band speed (v). An error signal (F) is generated by any deviation in the belt load values (q1, q2) of the weighing cells (5, 6) which are shifted by the time difference (t) calculated from the distance (D) and belt speed (v). To determine the belt speed (v), preferably a time phase shift is calculated by correlation of the two weighing signal curves (5b, 6b), and the calculated time difference (t) is used, taking into account the distance (D). In addition, a device is disclosed for carrying out this process.
Design and implementation of a weighted features model for the evaluation of archival websites

Purpose – The purpose of the present work was to design a comprehensive weighted features model for the specific evaluation of archival websites, and to apply it in practice to the particular population of Spain's web archives, ranking them in terms of quality based on the features they include. Design/methodology/approach – The design of the weighted features model is based on two parameters: the weight assigned to each feature according to its relevance for information retrieval from archival websites, and the archival website's degree of compliance with that feature. Findings – The results of the practical application of the model to the case of Spanish web archives showed that, contrary to prior expectation, factors which are intrinsic to the geographical region of Spain that the archive belongs to, such as economic level or degree of commitment to specific archival legislation, do not directly influence its website's quality ranking. Instead, the authors conclude that the population of archival websites presents its own particular behaviour. Originality/value – There has been a general lack of research specific to the analysis of the features of archival websites. The present work represents a certain advance in this regard in its proposal of a comprehensive weighted model of indicators for the specific evaluation of archival websites.
Diseño de un sistema energético para agilizar el proceso de secado de madera mediante la reconstrucción de la fuente de energía con la posibilidad de producción combinada de electricidad y calor

El proyecto tiene como objetivo racionalizar el proceso de secado de madera en la planta de procesamiento de madera. En el estado actual, los secadores de madera y los generadores de calor se accionan manualmente para su suministro, no hay ningún sistema de medición disponible. Es probable que los secadores consuman mucha más energía de lo que sería necesario. Una vez realizado el análisis, será posible medir correctamente las nuevas fuentes de energía para la biomasa, incluida la cogeneración a pequeña escala de electricidad a partir de biomasa.
Decoloration and detoxification of effluents by ionizing radiation

Abstract Three distinct textile samples were investigated for color and toxicity (S1–chemical/textile industry; S2–final textile effluent; S3 - standard textile produced effluent–untreated blue). Radiation processing of these samples were carried out at Dynamitron Electron Beam Accelerator and color and toxicity removal were determined: color removal by radiation was 96% (40 kGy, S1); 55% (2.5 kGy, S2) and 90% (2.5 kGy, S3). Concerning toxicity assays, Vibrio fischeri luminescent bacteria demonstrated higher reduction after radiation than the other systems: removal efficiencies were 33% (20 kGy, S1); 55% (2.5 kGy, S2) and 33% (2.5 kGy, S3). Daphnia similis and Brachionus plicatilis fitted well for S3 effluents. Hard toxic volumes into biological treatment plant may be avoided if radiation would be previously applied in a real plant. Results reveled how indispensable is to run toxicity to more than one living-organism.
Transformation of emerging contaminants in the aquatic environment. fate of transformation products under multiple stress conditions

Pharmaceutically active compounds (PhACs) are a special class of contaminants because they can undergo transformations through metabolism before their entrance into aquatic and terrestrial environments. Once they reach the environment they are further transformed by abiotic and/or biotic transformation processes and understanding of transformation pathways and identification of transformation products (TP) is a prerequisite for a thorough assessment of their environmental risk. This project proposes the use of Experimental Stream Facility (artificial rivers), a unique facility available at ICRA that will permit simultaneous study of biodegradation, photolysis, and adsorption /desorption processes under different situations, such as intermittent flow (drought), temperature or light fluctuations, among others. State of the art  hybrid and high resolution mass spectrometric instrumentation will be used to study transformation pathways and provide a comprehensive and detailed profile of TPs formed. By using an integrated approach and simultaneous study of biotic and abiotic transformation processes TRANSFORMER’s main expected results are: (i) elucidation of transformation pathways (biological and photo induced) and identification of main TPs from a number of relevant pharmaceuticals (including some understudied and, for the first time, a new class pharmaceuticals such as peptidomimetics and peptide therapeutics); (ii) determination of partition coefficients (water-sediment and water-biofilm) of the studied pharmaceuticals and TPs and (iii) identification of potential controlling factors and mechanisms behind in-stream attenuation of pharmaceuticals (biodegradation vs photodegradation vs sorption). Accordingly, we expect that the results produced by this innovative research plan will have substantial impact on the field of inland water research, one of the Europe’s Societal Challenges.
Auto- und Heterostereotypie im Europa des 19. Jahrhunderts

‚Vorurteil‘, ‚Feindbild‘, ‚Klischee‘ – die Synonyme, welche die Umgangssprache für ‚Stereotyp‘ bereithält, verweisen auf die negative Konnotation, die diesem Begriff in der Regel eignet. Nach allgemeiner Auffassung enthalten Stereotype in Wort oder Bild gefasste abwertende Aussagen über andere Gruppen, deren Verhalten, deren Einstellungen, deren Eigenschaften. Sie sind simplifizierend, resistent und diskriminierend: sie reduzieren und verallgemeinern auf unzulässige Weise; sie vermögen sich mitunter ungeachtet jahrzehntelanger Aufklärungsarbeit hartnäckig zu halten; und sie können, so sie auf einem breiten Konsens beruhen, teils auf subtile, teils auf brachiale Weise, nachhaltig sowohl zur Inklusion als auch zur Stigmatisierung und Exklusion ganzer Kollektive beitragen.
Strumento innovativo per l'apprendimento della programmazione tramite sensori IoT

Number_reference_aid_programma: SA.41471(2015/X) Finalità degli aiuti pubblici: Articolo 25 del regolamento (CE) n. 651/2014, del 17 giugno 2014, che dichiara talune categorie di aiuti compatibili con il mercato interno nell'applicazione degli articoli 107 e 108 del trattato È tutto qui. UE L 187/1 del 26.6.2014). Il progetto proposto chiamato CodeAll è uno strumento che insegna la programmazione e aiuta a sviluppare il pensiero algoritmico creando un ambiente intelligente utilizzando sensori IoT. Esso consente, ad esempio, di creare un sensore di parcheggio in auto, un frigorifero intelligente, accendere una spia battente, creare un allarme anti-scasso o ricevere una notifica quando una lettera arriva alla scatola o rileva il pianto di un bambino. La scienza è condotta da un assistente intelligente assistito dall'intelligenza artificiale chiamato CodeOwl. CodeOwl monitora il processo di programmazione e fornisce una guida che aiuta l'utente a creare nuovi programmi. CodeAll è uno strumento che consiste in una parte software e hardware. La parte hardware crea un pannello di controllo chiamato SmartBox, che si collega in modalità wireless a un insieme di sensori e attuatori. Dopo aver collegato la smartbox a un computer, telefono o tablet, è sufficiente accedere al portale in cui viene presentata una serie di lezioni. All'interno di ciascuno di essi, l'utente crea o modifica il codice del programma, dopodiché può caricarlo direttamente dal browser alla smartbox. Quando si avvia SmartBox si connette ai sensori ed esegue la programmazione delle azioni. CodeAll ti permette di acquisire le conoscenze di Junior Developer. L'ambito di studio riguarda i seguenti argomenti: variabili, tipi, operatori, istruzioni condizionali, funzioni, loop, classi e oggetti e debug del codice. Tuttavia, i sensori disponibili come parte di CodeAll possono essere utilizzati non solo per imparare la programmazione. Si tratta di dispositivi che possono essere utilizzati anche nell'industria, ad esempio per monitorare il processo di produzione.
A MODIS time series data based algorithm for mapping forest fire burned area

Burned area mapping is an essential step in the forest fire research to investigate the relationship between forest fire and climate change and the effect of forest fire on carbon budgets. This study proposed an algorithm to map forest fire burned area using the Moderate-Resolution Imaging Spectroradiameter (MODIS) time series data in Heilongjiang Province, China. The algorithm is divided into two steps: Firstly, the ‘core’ pixels were extracted to represent the most possible burned pixels based on the comparison of the temporal change of Global Environmental Monitoring Index (GEMI), Burned Area Index (BAI) and MODIS active fire products between pre- and post-fires. Secondly, a 15-km distance was set to extract the entire burned areas near the ‘core’ pixels as more relaxed conditions were used to identify the fire pixels for reducing the omission error as much as possible. The algorithm comprehensively considered the thermal characteristics and the spectral change between pre- and post-fires, which are represented by the MODIS fire products and the spectral index, respectively. Tahe, Mohe and Huma counties of Heilongjiang Province, China were chosen as the study area for burned area mapping and a time series of burned maps were produced from 2000 to 2011. The results show that the algorithm can extract burned areas more accurately with the highest accuracy of 96.61%.
FUSED BICYCLIC RAF INHIBITORS AND METHODS FOR USE THEREOF

The present disclosure relates to fused bicyclic Raf inhibitors of formula (I), (II), or (III), or a pharmaceutically acceptable salt, tautomer, or stereoisomer thereof. The disclosure also relates to method of using the compound of formula (I), (II), or (III), or a pharmaceutically acceptable salt, tautomer, or stereoisomer thereof, for treating diseases such as cancer, including colorectal cancer.
Multilayer capacitor.

Capacitor comprising a first and a second set of plates, the plates of the first set being electrically interconnected and being interspersed between the plates of the second set, these latter likewise being electrically interconnected. The capacitor comprises a first (A1-A5, B1-B5) and second (A6-A10, B6-B10) set of connections corresponding respectively to the electrical connections (1) between the plates (5) of the first set and to the electrical connections between the plates (6) of the second set, for each segment, these connections alternating. Application to industrial electronics. <IMAGE>