SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Dissecting the role of mitochondrial dynamics in pancreatic carcinogenesis

OPA1 Educates the Nucleus in Pancreatic CANcer.  Pancreatic cancer represents an unresolved health burden, showing abysmal chances of survival and refractoriness to conventional and immunological therapies. Significant benefit will be gained from a better understanding of molecular mechanisms leading to cancer formation, with the goal to curtail disease incidence and improve the opportunities to treat it early. The study will describe how mitochondria and nuclei communicate to facilitate pancreatic cancer initiation. Building from my prior research in metabolic-dependent histone acetylation, and leveraging on the host laboratory expertise in mitochondrial dynamics, I designed a roadmap for the study of how mitochondrial activity is altered during pancreatic carcinogenesis and whether that can be exploited for therapeutic purposes.  I will decipher the specific role of major cristae-remodeling factor OPA1, which is an unfavorable prognostic factor for pancreatic cancer patients. I will seek how OPA1-altered expression impacts mitochondrial function and metabolite availability in mouse pre-malignant cells, using in vivo models of pancreatic carcinogenesis. My previous experimentation found that metabolite-dependent histone acetylation is critical for the initiation of pancreatic carcinogenesis. I will now investigate whether OPA1-mediated mitochondrial rewiring impacts citrate and acetyl-CoA abundance in a way that alters the levels of histone acetylation. Epigenetic reprogramming will be further investigated in various OPA1 transgenic mice. Finally, the therapeutic potential of OPA1 targeting will be addressed using both genetic and chemical approaches using resources recently developed at the host laboratory. The project represents a career-defying framework for the study of molecular determinants of pancreatic cancer onset.
Quality Management, Environmental Management and Organizational Design in the Hotel Industry: A Qualitative Study

Quality Management, Environmental Management and Organizational Design in the Hotel Industry: A Qualitative Study The purpose of this paper is twofold. First, the paper analyzes the relationship between quality management and environmental management and their effects on hotel performance. Second, the article examines the relationship between these two management systems and organizational design. The paper uses an exploratory, qualitative approach based on interviews with managers and experts in the hotel industry. Based on a content analysis of interviews, the results lead to several propositions. Specifically, quality and environmental management influence hotel performance through mediating variables. Moreover, the implementation of quality management facilitates the implementation of environmental management. Furthermore, the implementation of these two management systems is associated with an increase of formalization and decentralization. The paper contributes to the analysis of quality management, environmental management, organizational design and performance in a joint manner, which has not been attempted before in the hotel industry. In addition, it helps extend the findings about these links in manufacturing and service organizations to the hotel industry.
The integration of mechanical and chemical signals in neuronal guidance

During the development of the central nervous system (CNS), neurons extend axons through a crowded environment along well-defined pathways to reach their distant targets. It isA start date of 1st June 2018 is being requested to enable the PI to complete a number of current commitments and put the necessary arrangements in place to enable an efficient start up phase of the project.  evident that attractive and repulsive guidance cues in the tissue provide important biochemical signals to guide growing axons along their paths. This can only be part of the story, however, as it is still not possible to predict axonal growth patterns in vivo. In a recent breakthrough discovery, we provided in vivo evidence that neurons also respond to mechanical cues, such as local tissue stiffness, suggesting that mechanical signals are likely an important missing part of the puzzle. However, mechanically activated signaling pathways are currently poorly understood, and how neurons integrate mechanical and chemical signals to result in proper outgrowth is unknown. 

By investigating how mechanical signals control neuronal growth and pathfinding, this proposal will close this comprehension gap. By combining state-of-the-art approaches in physics, engineering and biology, we will, for the first time, identify mechanosensitive molecular mechanisms that regulate neuronal growth and guidance in vitro and in vivo. In particular, we will investigate how mechanotransduction cascades (1) directly modulate axon growth by inducing local changes in cytoskeletal dynamics, and (2) indirectly lead to alterations in axon outgrowth by modulating chemical signalling pathways. Ultimately, we will develop a computational model based on our findings, which will lead to a predictive framework for understanding axon pathfinding in the developing brain. 

The proposed research challenges current concepts in developmental biology and is very relevant to many other areas in biology. Our results will not only shed new light on the complex control mechanisms of cellular growth and motility, but could also lead to novel biomedical approaches aimed at facilitating neuronal re-growth and regeneration in the damaged CNS.
The Characteristics of a Pair of Dual Binary Canonical Frames Generated by Refinable Functions

Materials science is an interdisciplinary field applyingthe properties of matter to various areas of science and engineering. Wavelet analysis has become a popular subject in researching into materials science during the past twenty years. Nowadays, it has been developed a mathematical br- anch. In this paper, we show that there exist binary wavelet frames generated by several compactly supported functions which have good dual binary wavelet frames, but for which the canonical dual binary wavelet frame does not consist of wavelets. That is to say, the canonical dual binary wavelet frame cannot be generated by the translations and dilations of a single binary function.
SYNTHETIC CHAMOIS FABRICS AND METHOD OF MAKING SAME

A synthetic chamois fabric having superior strength, color and performance is described, as is a method for its production. The fabric is woven from synthetic fiber-containing yarns, then desirably lubricated and subjected to a hydraulic face finishing process which serves to soften the fabric and increase its loft. The fabric is also desirably dyed and subjected to a pill-reduction treatment. The resulting fabric has a unique combination of washfastness, durability (both in wearing and washing), hand, wicking, soil release, crease retention, dimensional stability, and wrinkle resistance, while retaining a feel similar to that of the conventional cotton product. The fabric also has low air permeability in combination with desirable thermal insulating properties.
Subvention de fonds de roulement pour Katarzyna Bańska Aviatour — Office and Tourism Advisory

Le projet vise à aider l’entreprise à fournir des liquidités et à soutenir ses activités quotidiennes en raison de difficultés financières survenues dans l’entreprise à la suite de la pandémie de COVID-19. Assistance financière fournie sur la base du régime SA.57015.
Racial and Socioeconomic Status Differences in Depressive Symptoms Among Black and White Youth: An Examination of the Mediating Effects of Family Structure, Stress and Support

Stress research shows that race, socioeconomic status (SES), and family context significantly impact an adolescent's psychological well-being, yet little is known about the mediating effects of family context on racial and SES differences in depressive symptoms among Black and White youth. We investigate these associations using a sample of 875 (45% female) from a South Florida community-based study of youth mostly between the ages of 19 and 21. Ordinary least squares (OLS) analyses find that Blacks and lower SES youth have more depressive symptoms than Whites and those in higher SES families. Racial disparities are partially mediated by family related stressors and SES differences are fully explained by family stressors and emotional support. We also find that emotional family support conditions the relationship between race and depressive symptoms such that Whites experience more depressive symptoms at lower levels of emotional support but Blacks have more symptoms at higher levels. The findings highlight the importance of identifying factors within the family context that influence a youth's psychological well-being and ability to cope with adversities.
ROADWAY GUARD-RAIL ASSEMBLY

A guard rail for vehicular roadways consisting essentially of box-like rail members of downwardly open sheet-metal channels filled with a foamed elastomeric synthetic resin, with blade-like posts for the rails received in the synthetic resin mass. The walls of the channel are longitudinally corrugated or profiled.
SEPARATION OF REACTIVE CELLULOSE FROM LIGNOCELLULOSIC BIOMASS WITH HIGH LIGNIN CONTENT

A process for separating the components of lignocellulosic biomass for the purpose of producing a pure reactive cellulose is disclosed. The process has two stages. In the first stage, the lignocellulosic biomass is pretreated with steam, with or without an acid catalyst and then pressed, with or without the presence of an eluent. to remove hemicellulose and other impurities. In the second stage, the pretreated biomass is extracted with a solvent such as ethanol with or without acid catalysts in order to remove lignin and release a purified cellulose stream. The extracted cellulose is then rapidly decompressed to rupture the fibrous structure. The process provides a purified cellulose stream that is relatively easy to hydrolyze with enzymes and ferment to biofuels and other chemicals such as ethanol.
Red Wine Again?

In their article, Hsu et al. describe how a specific constituent of cigarette smoke (dioxin) negatively influences bone morphogenetic protein (BMP)-2-mediated spinal fusion in rats. On the basis of their findings, they speculate on potential therapeutic options to improve fusion in spinal arthrodesis and bone-healing in other orthopaedic procedures in patients who continue smoking.

Recently, a detailed overview of the adverse effects of smoking on the musculoskeletal system was published in The Journal of Bone & Joint Surgery 1 . These negative effects can be roughly summarized as (1) prothrombotic effects with, among others, an increased risk of osteonecrosis; (2) metabolic effects resulting in decreased bone strength with subsequent increased fracture risk; (3) anti-osteogenic effects with decreased healing capacity of fractures and osteotomy and arthrodesis sites; and (4) other general adverse effects increasing the risk of perioperative complications such as wound-healing disturbances.

Although the specific effects of many toxic substances in cigarette smoke, such as carbon monoxide and nicotine, have been established in terms of tissue oxygenation, carcinogenesis, and addiction, it is unclear which toxic substances specifically cause adverse musculoskeletal effects. The role of nicotine, the main addictive substance, is especially controversial regarding the often-reported positive effect …
Preliminary economic assessment: a valuable tool to establish biocatalytic process feasibility with an in-lab immobilized lipase

BACKGROUND: Despite the interest that commercial lipases arouse, the number of industrial applications is still very limited. Only high added value products such as cosmetic ingredients that can simultaneously benefit from ‘green chemistry’ and ‘natural’ labels of using biocatalysts can justify the final cost. In any case, process feasibility economic assessment in the first project stages must be done to take decisions about its industrial applicability. RESULTS: This work presents an economic study of the cetyl esters mixture production process similar to natural spermaceti catalyzed by different in‐lab immobilized lipase derivatives to determine if they can compete, not only in catalytic properties (activity and stability) but also in price, with the commercial ones. Results highlight that CALB lipase immobilized in Amberlite™ XAD™ 1180 whose direct total cost (1.20 € g⁻¹) is comparable with commercial lipases, is also effective in spermaceti biocatalytic synthesis achieving, under optimal conditions, 98% conversion in less than one hour. CONCLUSION: High conversion values and it reusability (at least 15 times), provides a product with a price (58 € kg⁻¹) similar to that of the well‐known Novozym® 435 (56.5 € kg⁻¹). Future scale‐up will allow better study the process and gives a more realistic product final price. © 2018 Society of Chemical Industry
Implementing Seaplanes System in Adriatic Basin

ADRI-SEAPLANES aim is to create the best conditions for the set up of stable connections through a common seaplane system. The Adriatic areas of Italy, Greece, Albania, Croatia and Montenegro, in fact, even if very closed in terms of nautical miles, are linked only through the maritime system and not by direct air connections. This condition allows only the reach of the countries involved with a lack of time, situation that affect the establishment of stable economic relations. The maritime routes, in fact, are covered only through the commercial relations between the main international Adriatic ports through RO/PAX vessels with a period of travel, sometimes, more than ten hours. Seaplane transport is very common and used in some area of the world, and thde Adriatic basin offer an important network, constituted by its Ports in order to introduce a new seaplane system. Through the project, in fact, partners intends to develop an alternative and faster way of transport through the set up of a stable seaplane connection, through the following steps: 1) harmonization of the conditions at normative, operational and structural level in order to facilitate investments from all the European countries; 2) give ports the small infrastructural level, supported by the mandatory investments related to security in order to obtain the status of water airports 3) involvement of the private sector in the activities, as indirect beneficiaries of project results; 4) Support at political, instritutional and operational level of the newly established seaplane system through the set up of an Adriatic seaplane Steering Committee, whose aim is also to enlarge the network of seaplane also to other Adriatic Ports. The results of the project are the reinforcing of Ports services and facilities through the offer an alternative way of transport, in order to make ports more competitive, to streghten the commercial and business relations in the project area. A pilot project is foreseen, which intends to test the functionality of the common normative and operational activities through the charter of a seaplane. In order to improve the seaplane system, an on-line common booking service is foreseen. The involvement of stakeholders and operators in the development of the project intends to spread in project area the use of seaplanes instead of airplanes or boats.
A variable hard sphere-based phenomenological inelastic collision model for rarefied gas flow simulations by the direct simulation Monte Carlo method

A modified phenomenological model is constructed for the simulation of rarefied flows of polyatomic non-polar gas molecules by the direct simulation Monte Carlo (DSMC) method. This variable hard sphere-based model employs a constant rotational collision number, but all its collisions are inelastic in nature and at the same time the correct macroscopic relaxation rate is maintained. In equilibrium conditions, there is equi-partition of energy between the rotational and translational modes and it satisfies the principle of reciprocity or detailed balancing. The present model is applicable for moderate temperatures at which the molecules are in their vibrational ground state. For verification, the model is applied to the DSMC simulations of the translational and rotational energy distributions in nitrogen gas at equilibrium and the results are compared with their corresponding Maxwellian distributions. Next, the Couette flow, the temperature jump and the Rayleigh flow are simulated; the viscosity and thermal conductivity coefficients of nitrogen are numerically estimated and compared with experimentally measured values. The model is further applied to the simulation of the rotational relaxation of nitrogen through low- and high-Mach-number normal shock waves in a novel way. In all cases, the results are found to be in good agreement with theoretically expected and experimentally observed values. It is concluded that the inelastic collision of polyatomic molecules can be predicted well by employing the constructed variable hard sphere (VHS)-based collision model.
147 EXCESSIVE REDUCTION IN HVPG IS PREDICTIVE OF MORTALITY AFTER TRANSJUGULAR INTRAHEPATIC PORTOSYSTEMIC SHUNT (TIPS)

Introduction: Hepatic Encephalopathy (HE) is a serious complication of chronic liver disease characterized by complex neuropsychiatric abnormalities that range from mild confusion to coma. Although there have been different treatment options for HE, lactulose (a nonabsorbable disaccharide, NADS) has been most commonly used and remains the mainstay of therapy. Rifaximin is a non-absorbable antibiotic and was recently approved by FDA for prevention of recurrent HE. Several small trials in the past have compared the effectiveness of rifaximin and NADS in management of HE. The results of these trials have been conflicting and limited due to small number of subjects involved. Aim: We therefore conducted a metaanalysis of Randomized controlled trials (RCT) to evaluate the efficacy of rifaximin in comparison to NADS. Methods: Two reviewers searched MEDLINE, EMBASE, CINAHL and the Cochrane Database using search terms “hepatic encephalopathy”, “rifaximin, “lactulose”, “lactitol”, “non-absorbable disaccharides”, “cirrhosis”. Inclusion criteria were:1) Studies involving patients with HE 2) study be a RCT 3) comparison of rifaximin with NADS (either lactulose or lactitol). The review was done per guidelines of PRISMA statement and methodological quality evaluated using Jadad scoring system. The results were pooled and relative risk ratio and 95% confidence interval (95% CI) derived using fixed effect estimates using STATA 10. Results: Five studies with a total of 259 patients met the pre-specified inclusion criteria. Of these 134 were randomized to rifaximin while 125 to NADS. In comparison to NADS, use of rifaximin was associated with significant reduction in risk of no improvement of HE (RR 0.57, 95% CI 0.35 0.94, p = 0.028). There was no significant heterogeneity amongst studies with Chi square statistic = 3.9, p = 0.41, I squared statistic = 0.0%. Discussion: Rifaximin is more beneficial in comparison to NADS in management of HE. Although Lactulose is used as the first line agent, frequent side effects such as bloating, flatulence, diarrhea limit tolerability. Rifaximin is not absorbed systemically and thus better tolerated. Further research should explore the optimum treatment duration for HE and costanalysis with use of rifaximin.
“Todo cambia, todo sigue igual”. La gobernanza de la mano de obra migrante en la agricultura española e italiana en el primer año de la pandemia de Covid-19

La pandemia de la COVID-19 junto con las políticas adoptadas para contener la propagación del virus, tensionaron profundamente las cadenas de suministro de alimentos. En ello, la temprana escasez de mano de obra en la agricultura surgida a raíz de estos acontecimientos en España e Italia puso de manifiesto el papel esencial de los trabajadores agrícolas migrantes para garantizar la seguridad alimentaria. El propósito de este artículo es doble: en primer lugar, se perseguirá examinar si la pandemia causada por el coronavirus contribuyó a cambiar las actitudes públicas y políticas hacia el trabajo agrícola y la migración; en segundo lugar, se evaluará qué tipo de perspectiva epistemológica prevaleció en estos países al debatir sobre migración estacional y agricultura industrial. Para ello, el artículo utilizará una combinación de métodos de investigación basados en el Enfoque Crítico del Discurso que incluye una revisión sistemática de noticias producidas por los medios de comunicación, el examen de actos jurídicos y administrativos, el estudio de los datos estadísticos secundarios y, por último, el análisis de las autorrepresentaciones y propuestas formuladas por los trabajadores agrícolas migrantes y los sindicatos a través de sus blogs, sitios web y cuentas de Facebook. Las principales tendencias identificadas en este análisis señalan que, aunque la pandemia contribuyó a arrojar luz en ambos países sobre el papel fundamental de los trabajadores migrantes y las formas de explotación laboral moderna que sufren en el sector agrícola, esta mayor visibilidad no se tradujo en cambios reales de políticas y actitudes. Como se pondrá de manifiesto, en el centro de este problema se encuentra la separación ficticia entre el trabajo y el capital, por la que la mano de obra agrícola migrante permanece al margen de los grandes debates introducidos por las economías avanzadas europeas, centradas exclusivamente en el capital.
The “Transition thinking” and 50 plus generation thoughts of sustainability in different countries (Case study in hungary and switzerland)

Transition thinking is a normative and practice oriented approach on sustainability development, which implements the knowledge of different fields of science, extended with practice experience. The main goal is to invigorate society by establishing new communities, partnerships and social networks. This social cooperation helps put appropriate pressure on decision makers and political groups, through which we can make sure that transition processes have the proper long-term orientation and goals. In case of the generally aging European society, the question if the 50 plus generation is merely affected by, or involved in the transition process is gaining a decisive importance, since this generation has a more and more important role in shaping the standards of consumer systems, and accelerating or hampering the processes aimed at sustainability. In our thesis, we introduce the attitudes shown by the 50 plus generation regarding their view on the sustainable values, and the transition to sustainable consumer systems on the different levels of the European society.
Flood risk assessment for infrastructure networks

A practical framework for flood risk screening was developed to assess the flood risk to water utility assets within the infrastructure network. The tool is a combination of probability and consequence assessments. The first takes into account how probable it is for a particular asset to flood and cause significant damage. The second estimates the level of consequences a flood will have, considering, for example, the level of loss of service, environmental pollution and cost. The consequence assessment is based on a dependency assessment that identifies knock-on effects on other assets within the asset network and assesses the level of consequence they will have. The probability and consequence assessments are combined to produce a risk score that can be used to rank assets in a screening process that aims to assist companies in prioritising the investments required for taking action to reduce flood risk to their assets.