SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
The quantum structure of black holes and the recovery of information

The detection of black-hole mergers in 2015 was a spectacular confirmation of General Relativity (GR). Yet, it is also in black holes that the fundamental conflict between GR and quantum mechanics (QM) is most acute.  Black holes are known to have a vast entropy.  Consistency with QM requires that the microstates giving rise to this entropy must be accessible at the horizon scale. However, GR coupled to field theory is incapable of supporting this horizon-scale microstructure!  My work has shown that Microstate Geometries (MG’s), based in string theory and higher-dimensional field theory, have all the essential elements for supporting and encoding microstate data:  MG’s are smooth, horizonless solutions in string theory that are identical to black holes on large scales but differ radically from the black holes of GR at the horizon scale.

I propose to launch a new, extensive study of the MG paradigm, focussing on the, as yet, unexplored dynamics of the microstructure in MG’s: (i) How infalling matter is absorbed and diffused into excitations of MG’s; (ii) How the excitations of MG’s, and the MG’s themselves, decay into some form of Hawking radiation that carries the microstructure data to infinity, thereby preserving quantum unitarity; (iii) How the large-scale, collective dynamics of microstructure interacts with matter in the horizon region and, particularly, how microstructure dynamics influences accretion disks and black-hole mergers. Progress will be achieved by analyzing the energy transfer between infalling probes and MG’s, computing the resulting excitations of the MG and the drag on infalling objects. The results will be re-expressed in a hydrodynamic form that can be applied to simulations of astrophysical black holes. 

This proposal will thus solve the information paradox by providing a microscopic description of black-hole entropy at the horizon scale and this should lead to macroscopic, measurable signatures of the horizon-scale microstructure.
Ajuste del cálculo de las dotaciones de los hidrantes a la geometría de las parcelas

Este estudio se desarrolla en el sector de riego XXIV de la Ampliacion de la 1a Fase del Canal de Navarra (Espana). Dicha ampliacion forma parte del sistema Itoiz – Canal de Navarra, que recorre la comunidad foral abasteciendo de agua de boca y de riego a una multitud de localidades. Una caracteristica que define a dicho sector es la complicada geometria de sus unidades de riego. El proceso de construccion de esta ampliacion sigue el siguiente orden, en primer lugar, el dimensionamiento de los hidrantes que suministraran caudal a las parcelas y posteriormente la instalacion de dichas parcelas. En el sector XXIV, una vez ejecutadas las instalaciones de parcela se ha comprobado que la demanda de caudal de ciertas unidades de riego (UURR) es superior a las dotaciones asignadas previamente en el diseno de la red general. Esto provoca un descenso en la uniformidad y eficiencia del riego en la parcela. En el presente trabajo se plantea relacionar la demanda de caudal de las UURR con su geometria, ...
Safety, tolerability and anti-tumour activity of the androgen biosynthesis inhibitor ASP9521 in patients with metastatic castration-resistant prostate cancer: multi-centre phase I/II study

ASP9521 is a first-in-class orally available inhibitor of the enzyme 17 β-hydroxysteroid dehydrogenase type 5 (17 βHSD5; AKR1C3), catalysing the conversion of dehydroepiandrosterone and androstenedione into 5-androstenediol and testosterone. It has demonstrated anti-tumour activity in in vitro and in vivo preclinical models.This first-in-man phase I/II study utilised a 3 + 3 dose escalation design starting at 30 mg ASP9521/day, with the aim of defining a maximum tolerated dose, as defined by the incidence of dose-limiting toxicities. Eligible patients received ASP9521 orally for 12 weeks. Safety, tolerability, pharmacokinetics (PK), pharmacodynamics and anti-tumour activity were assessed.Thirteen patients (median age: 68 years; range 52-76) with metastatic castration-resistant prostate cancer (mCRPC) progressing after chemotherapy were included; 12 patients discontinued treatment at or before week 13, mainly due to disease progression. The most common adverse events were grade 1/2 and included asthenia (N = 5), constipation (N = 4), diarrhoea (N = 3), back pain (N = 3) and cancer pain (N = 3). PK demonstrated a half-life (t1/2) ranging from 16 to 35 h, rapid absorption and dose proportionality. No biochemical or radiological responses were identified; neither endocrine biomarker levels nor circulating tumour cell counts were altered by ASP9521. Given the lack of observable clinical activity, the study was terminated without implementing a planned 12-week dose expansion part at selected doses or a planned food-effect study part.In patients with mCRPC, ASP9521 demonstrated dose-proportional increase in exposure over the doses evaluated, with an acceptable safety and tolerability profile. However, the novel androgen biosynthesis inhibitor showed no relevant evidence of clinical activity.
Deep-Learning and hpc to boost biomedical applications for health

Health scientific discovery and innovation are expected to quickly move forward under the so called “fourth paradigm of science”, which relies on unifying the traditionally separated and heterogeneous high-performance computing and big data analytics environments. 
Under this paradigm, the DeepHealth project will provide HPC computing power at the service of biomedical applications; and apply Deep Learning (DL) techniques on large and complex biomedical datasets to support new and more efficient ways of diagnosis, monitoring and treatment of diseases. 
DeepHealth will develop a flexible and scalable framework for the HPC + Big Data environment, based on two new libraries: the European Distributed Deep Learning Library (EDDLL) and the European Computer Vision Library (ECVL). The framework will be validated in 14 use cases which will allow to train models and provide training data from different medical areas (migraine, dementia, depression, etc.). The resulting trained models, and the libraries, will be integrated and validated in 7 existing biomedical software platforms, which include: a) commercial platforms (e.g. PHILIPS Clinical Decision Support System from or THALES SIX PIAF; and b) research oriented platforms (e.g. CEA`s ExpressIF™ or CRS4`s Digital Pathology). Impact is measured by tracking the time-to-model-in-production (ttmip).
Through this approach, DeepHealth will also standardise HPC resources to the needs of DL applications, and underpin the compatibility and uniformity on the set of tools used by medical staff and expert users. The final DeepHealth solution will be compatible with HPC infrastructures ranging from the ones in supercomputing centers to the ones in hospitals.
DeepHealth involves 21 partners from 9 European Countries, gathering a multidisciplinary group from research organisations (9), health organisations (4) as well as (4) large and (4) SME industrial partners, with strong commitment towards innovation, exploitation and sustainability.
Een scotland eimc

The project’s underlying objective is to to encourage smart inclusive and sustainable growth in the EU by increasing effective investment in innovation linked to profitable exploitation in international markets.

The project’s specific objective is to ensure that Scottish SMEs with international innovation and growth ambitions are empowered by unlocking their full growth potential through better internal innovation management capability and tailored mentoring and coaching.   The aim is to support SME’s international competitiveness through the exploitation of new or enhanced products, process or service through improved innovation efficiency.

To this end, the project will seek to improve the innovation performance of Scottish SMEs, both for beneficiaries of the SME Instrument (through the Key Account Management service: KAM Service) and for the wider SME innovation base (through the innovation management capacity building service: EIMC Service).
Specific objectives include: 

• Identification of bottlenecks to the creation of economic impact in companies benefiting from grants by Horizon2020's SME instrument and addressing these bottlenecks with the help of capable coaches.
• Increasing the efficiency and effectiveness of innovation processes in SMEs with significant innovation activities that could potentially become beneficiaries of European support to research and innovation but would not have effective access to consulting services for innovation management.
• Ensure EEN Scotland staff have the competencies to engage professionally with high-end target companies.
Controlling the Leidenfrost Temperature Through Laser-Assisted Surface Micro/Nano Texturing

In the present work, the effect of surface features and wettability on the Leidenfrost temperature are experimentally investigated. The surface features were fabricated on a 304 stainless steel surface using a femtosecond laser. This technique allows for a wide variety of surface microstructures (spikes, mounds, holes, and pyramids) to be created, ranging in size, shape, and spacing. Changing the fluence and shots of the laser produce different micro/nano textured surfaces. A smooth surface sample was fabricated as a reference surface with a measured Leidenfrost temperature as a benchmark. The droplet lifetime experimental method was employed to determine the Leidenfrost temperature for both the smooth and the textured surfaces. A precision dropper was used to control the droplet size to 4.2 microliters (diameter of 2.0mm) while surface temperatures were measured by means of an embedded thermocouple. In comparison to the smooth stainless steel surface, a shift in the Leidenfrost temperature, as high as 55 °C, was observed with the textured surface. The textured surface hasa high emissivity, compared to the smooth surface. As a result, in addition to the shift in the Leidenfrost temperature, significant enhancement of the film boiling heat transfer coefficients were also observed.
DEVICE FOR RELEASABLY FIXING A WORKPIECE TO BE MACHINED, FRAME FOR RECEIVING AT LEAST ONE SUCH DEVICE, AND METHOD FOR SUPPORTING THE WORKPIECE TO BE MACHINED

The invention relates to a device (1) for releasably fixing a workpiece (2) to be machined, wherein the device (1) comprises a support strut (3), the end of which closest to the workpiece (2) is equipped with a workpiece support (5) bearing indirectly or directly against the workpiece surface (4). In accordance with the solution according to the invention, the end of the support strut (3) opposite the workpiece (2) is mounted in a housing (6) of the device (1) such that the support strut is pivotable, rotatable and the axial length of the support strut is variable. The invention additionally describes a frame for receiving at least one device of this kind and also a method for supporting a workpiece (2) to be machined on a frame (25) equipped with at least one device (1).
Unravelling the mechanism of nuclear transport using optical nanopores

The nuclear pore complex (NPC) is the gatekeeper of the nucleus that regulates the flow of all molecules across the nuclear envelope. Remarkably, this ~40 nm wide pore is capable of efficient and fast transport while remaining highly selective. Its dense central channel is composed of a highly dynamic spaghetti-like mesh of intrinsically disordered proteins that allows small molecules to pass freely, whereas large macromolecules (>40 kDa) rely on specific transporter proteins that ferry their cargo across the pore. Even though various models have been proposed, the fundamental biophysical mechanism of nuclear transport and of the selectivity of the NPC has not been resolved yet. One of the main reasons that have hindered our progress in understanding nuclear transport is the lack of experimental techniques that can probe the structure and dynamics of the disordered proteins and transport receptors inside the NPC channel and during transport with sufficient spatiotemporal resolution. In the proposed action, I aim to establish a modifiable biomimetic platform for single-molecule investigations of nuclear transport. This interdisciplinary and innovative approach combines solid-state nanopores, coated with disordered proteins to mimic the nuclear pore, with optical detection in zero-mode waveguides and DNA origami nanotechnology. The proposed experiments will allow to monitor the translocation of single fluorescently labelled molecules through biomimetic NPCs with excellent sensitivity and specificity. I will use this platform to elucidate the biophysical principles that underlie the structure and selectivity of the NPC channel and the mechanism of active nuclear transport. The direct insights on the single-molecule level obtained by the results of this project will be crucial for our understanding of the molecular principles that govern nuclear transport.
HEPARANASE DEFICIENT NON-HUMAN MAMMALS

The invention relates to cells and transgenic non-human mammals having at least one disrupted heparanase allele. The invention further relates to methods of screening therapeutic drug candidates utilizing the heparanase deficient non-human mammals and cells.
Dozaj ve Agrega Granülometrisinin Hafif Betonların Isı İletkenliğine / Effect of Grading and Cement Contents on The Heat Conductivity Values of Lightweight Concrete

OZET: Bu calisma, Dogu Anadolu Bolgesi, Erzurum Ili Pasinler ilcesi yoresinde ekonomik potansiyeli bulunan hafif agrega ocagindan saglanan agregayla uretilen hafif betonlarin isi iletkenlik ozelliklerinin belirlenmesi amaciyla yapilmistir. Arastirma konusu olan hafif agregaya, ilgili standartlardaki deneyler uygulanmis ve agrega ozellikleri saptanmistir. Ozellikleri bilinen agreganin farkli iki granulometrisi kullanilarak uc ayri dozajli hafif betonlar olusturulmustur. Sertlesmis betonlarda 28 gunluk birim agirlik ve isi iletkenlik degerleri belirlenmistir. Elde edilen sonuclar, hafif agregayla uretilen betonun dusuk birim agirlik ve isi iletkenlik degerlerine sahip oldugunu, dogal ve ayarlanmis granulometrili agregayla uretilen betonlar arasinda cok buyuk farklilik olmamakla birlikte ayarlanmis granulometrili betonlarin daha dusuk isi iletkenlik degerleri verdigini gostermistir. Anahtar Kelimeler: Hafif beton, isi iletkenligi, dozaj, tane dagilimi Effect of Grading and Cement Contents on The Heat Conductivity Values of Lightweight Concrete ABSTRACT: This research was carried out to determine heat conductivity properties of concrete produced with natural lightweight aggregates in Eastern Anatolian Region, Erzurum-Pasinler province that has economical potential. Aggregate properties were determined using the related standarts of lightweight aggregates. To produce lightweight concrete, lightweight aggregates were used in natural and adjusted grading and in three different cement contents. Unit weight of 28 days and heat conductivity were determined for hardened concrete. The results obtained have shown that concrete produced with lightweight aggregates have low unit weight and heat conductivity, however no significant differences were found between the concrete produced with natural and adjusted grading. Lightweight concrete produced with adjusted grading has shown low heat conductivity values. Key Words: Lightweight concrete, heat conductivity, cement contents, grading
AN INTRA VAGINAL DEVICE TO AID IN TRAINING AND DETERMINING MUSCLE STRENGTH

An intra vaginal device (10) including an elongated hollow body (1 1) with side wall portions (15, 16 and 24). Secured to each wall portion (15 and 24) is a sensor (19), while secured to the wall portion (16) is a sensor (20). The sensors (19) simply measure forces directly applied by the bi-lateral contraction of the pubococcygeus, while the sensor (20) provides an indication of the puborectalis contraction forces.
One modulo N gracefulness of splitting graphs and subdivision of double triangle graphs

A function f is called a graceful labelling of a graph G with q edges if f is an injection from the vertices of G to the set {0, 1, 2, . . ., q} such that, when each edge xy is assigned the label |f(x) − f(y)|, the resulting edge labels are distinct. A graph G is said to be one modulo N graceful (where N is a positive integer) if there is a function φ from the vertex set of G to {0, 1, N, (N + 1), 2N, (2N + 1), . . . , N(q − 1), N(q − 1) + 1} in such a way that (i) φ is 1 − 1 (ii)φ induces a bijection φ* from the edge set of G to {1, N + 1, 2N + 1, . . . , N(q − 1) + 1} where φ*(uv)=|φ(u) − φ(v)| . In this paper we prove that S’(P2n) , S’(P2n+1) , S’(K1,n) , all subdivision of double triangular snakes (2Δk-snake) and all subdivision of 2mΔk-snake are one modulo N graceful for all positive integers N.
Value-Free Analysis of Values: A Culture-Based Development Approach

Recent literature in the fields of Political Economy, New Institutional Economics and New Cultural Economics has converged in the use of empirical methods, offering a series of consistent quantitative analysis of values. However, an overarching positive methodology for the value-free study of values has not yet precipitated. Building on a mixed systematic-integrative literature review of a pluralistic variety of perspectives from Adam Smith’s ‘Impartial’ Spectator to modern moral philosophy, the current study suggests the Culture-Based Development (CBD) approach for analyzing the economic impact of values on socio-economic development. The CBD approach suggests that the value-free analysis needs: (i) to use positive methods to classify a value as local or universal; (ii) to examine the existence of what is termed the Aristotelian Kuznets curve of values (i.e., to test for the presence of an inflection point in the economic impact from the particular value) and (iii) to account for Platonian cultural relativity (i.e., the cultural embeddedness expressed in the geographic nestedness of the empirical data about values). The paper details the theoretical and methodological cornerstones underpinning the proposed CBD approach for value-free analysis of values.
Q&As with Marsha I. Lester

Evidence of Earth’s changing environment is abundant, from diminished polar ice caps to increased frequency of catastrophic storms. However, the chemical reactions in our atmosphere that can contribute to a changing climate are less well known. A physical chemist at the University of Pennsylvania who studies the troposphere, Marsha I. Lester combines experiment, theory, and modeling to investigate the chemistry at the edge of our planet. Her group examines the oxidation of man-made and biogenic volatile organic compounds, such as alkenes. The reactions proceed through transitory species known as Criegee intermediates, which were first predicted in the 1950s but only recently observed. Lester’s group generated these intermediates, characterized them using spectroscopy, and measured the rates of their decay to hydroxyl radicals, which are key oxidants in the troposphere. The research has enriched our understanding of atmospheric chemistry and might reveal how the atmosphere can repair itself. PNAS recently spoke to Lester, who was elected to the National Academy of Sciences (NAS) in May 2016, about her current research.



Marsha I. Lester. Image courtesy of Felice Macera (University of Pennsylvania, Philadelphia).



> PNAS:Your work with Criegee intermediates reveals how oxidants in the troposphere can “cleanse” the atmosphere. How does this occur, and what …
Launching (g)local level heritage entrepreneurship: strategies and tools to unite forces, safeguard the place, mobilize cultural values, deliver the experience.

Cultural consumption is a knowledge based activity: cultural products and services are viable, only if they possess widely recognized values. SAGITTARIUS advances cultural consumption by communicating cultural values: from natural monuments and ecosystems to sites and collections, from the arts to traditions and handicrafts. Thus values of tangible-intangible, movable-immovable and spiritual heritage assets become catalysts for regeneration and development by being revealed and communicated. Given the diversity and complexity of heritage, the use of cultural values for development is feasible, only if multilateral interactions are understood and reflected in policy and delivery. Required is a multivalent and flexible nexus at local-global level to mitigate the protection-use conflict reconciling national and international strategies. SAGITTARIUS provides the Cooperation Area with an activity mix to fully realize the socioeconomic potential of culture: put into practice is an integrative management system to classify and signify natural, man made and spiritual heritage assets and communicate their values to different audiences across the SEE. To promote entrepreneurial culture in the heritage sector, SAGITTARIUS encourages the formation of heritage entrepreneurs: a participatory knowledge platform transfers advanced tools among multilevel actors to protect and use heritage assets by identifying their environmental, social, historic, aesthetic, spiritual and special values; domain specific training certifies individuals with increased capacities certifying professional skills. Implemented pilot actions on a social inclusion basis, provide for cultural experience diversity connecting thus local cultural production to international markets. By activating public-private-third sector alliances, heritage entrepreneurship is established at transnational level, exemplifying, how heritage is valued, protected, communicated and used with ecologic, economic and social profit.
Development of Automatic Visceral Fat Volume Calculation Software for CT Volume Data

Objective . To develop automatic visceral fat volume calculation software for computed tomography (CT) volume data and to evaluate its feasibility. Methods . A total of 24 sets of whole-body CT volume data and anthropometric measurements were obtained, with three sets for each of four BMI categories (under 20, 20 to 25, 25 to 30, and over 30) in both sexes. True visceral fat volumes were defined on the basis of manual segmentation of the whole-body CT volume data by an experienced radiologist. Software to automatically calculate visceral fat volumes was developed using a region segmentation technique based on morphological analysis with CT value threshold. Automatically calculated visceral fat volumes were evaluated in terms of the correlation coefficient with the true volumes and the error relative to the true volume. Results . Automatic visceral fat volume calculation results of all 24 data sets were obtained successfully and the average calculation time was 252.7 seconds/case. The correlation coefficients between the true visceral fat volume and the automatically calculated visceral fat volume were over 0.999. Conclusions . The newly developed software is feasible for calculating visceral fat volumes in a reasonable time and was proved to have high accuracy.