SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Incidência do câncer de pênis no Brasil

O Câncer de Pênis (CP) é um tumor genital, tem alta incidência em países subdesenvolvidos, cerca de 26.000 casos novos a cada ano. No Brasil, o CP representa 2% dos tipos de canceres que afeta o sexo masculino, com maior incidência na região norte e nordeste, que pode chegar até 10%. O surgimento do CP é multifatorial e pode estar relacionado à higiene inadequada, fimose em adultos, tabagismo, muitos parceiros sexuais e HPV. Em geral o CP é indolor, mas pode apresentar dor, sangramento e mal cheiro. Os sintomas característicos são lesões vegetantes e úlceras ou lesões intrauretrais e muitas vezes os pacientes desconhecem sua presença. O presente artigo traz uma revisão integrativa de literatura baseada em informações relevantes para demonstrar a incidência do CP no Brasil e suas principais características, como: fatores de risco, sintomas, prevenção e tratamento. Diante dos dados apresentados pelos artigos é observado que as regiões norte e nordeste realmente são os locais do país com maior incidência. Também é analisado que o CP atinge com mais frequência homens com idade próxima a 60, porém jovens também podem ser acometidos pela doença. A presença da fimose dificulta a limpeza do órgão que gera secreções irritantes à pele, por isso o CP está bastante presente em homens com essa condição.
Pump architecture linked to aircraft cooling expectations

The PALACE project aims to develop a new generation of pump architecture for electrical machines cooling for aircrafts. It meets Clean Sky 2 (CFP03) objectives by significantly reducing weight, by increasing durability, and availability as required by aircraft manufacturers.

The PALACE approach goes a step further, with a challenging objective of a 30% mass reduction, using non-conventional solutions, such as additive manufacturing processes, enabling hollow structures for some components of the pump. New coatings and new functional surfaces texturing will complete the design, with regards to friction, lubrication and thermal performances at the required very high speed conditions. Innovation in PALACE is not limited to new manufacturing processes but will rise up also from the combination of several design methodologies (Design For Manufacture and Assembly, tribology, topology and CETINNOV - a CETIM specific proven innovation methodology) along with a multi physics expertise. The multiphase Computational Fluid Dynamics - CFD models including oil cavitation, CFD tool shapes optimisation will address the high efficiency performances. PALACE will address the optimisation issue not only at the pump level but broaden the view at the whole cooling system level and make recommendations for more system optimisation.
The consortium’s ambition is to develop a European, clean, robust and efficient pump architecture that will be implemented into most of systems of the More Electric Aircraft.  SERV (SME), as one of the few European aeronautic pump manufacturers, associated to CETIM, a mechanical research centre, have the competences and ambition to bring the PALACE pump to the European market. The project will lead to an ITAR free (International Traffic in Arms Regulations) export. Partners are willing to transfer the PALACE innovations in other sectors searching for high performances such as the space, nuclear power, energy transfer or the auto racing industries.
The brown dwarf atmosphere monitoring (BAM) project – II. Multi-epoch monitoring of extremely cool brown dwarfs

With the discovery of Y dwarfs by the WISE mission, the population of field brown dwarfs now extends to objects with temperatures comparable to those of Solar System planets. To investigate the atmospheres of these newly identified brown dwarfs, we have conducted a pilot study monitoring an initial sample of three late T-dwarfs (T6.5, T8 and T8.5) and one Y-dwarf (Y0) for infrared photometric variability at multiple epochs. With J-band imaging, each target was observed for a period of 1.0h to 4.5h per epoch, which covers a significant fraction of the expected rotational period. These measurements represent the first photometric monitoring for these targets. For three of the four targets (2M1047, Ross 458C and WISE0458), multi-epoch monitoring was performed, with the time span between epochs ranging from a few hours to ~2 years. During the first epoch, the T8.5 target WISE0458 exhibited variations with a remarkable min-to-max amplitude of 13%, while the second epoch light curve taken ~2 years later did not note any variability to a 3% upper limit. With an effective temperature of ~600 K, WISE0458 is the coldest variable brown dwarf published to-date, and combined with its high and variable amplitude makes it a fascinating target for detailed follow-up. The three remaining targets showed no significant variations, with a photometric precision between 0.8% and 20.0%, depending on the target brightness. Combining the new results with previous multi-epoch observations of brown dwarfs with spectral types of T5 or later, the currently identified variables have locations on the colour-colour diagram better matched by theoretical models incorporating cloud opacities rather than cloud-free atmospheres. This preliminary result requires further study to determine if there is a definitive link between variability among late-T dwarfs and their location on the colour-colour diagram.
PERFIL DO PROFESSOR PARA ATUAR NO SÉCULO XXI

O estudo denominado Perfil do Professor para Atuar no Século XXI traça um breve caminho percorrido na formação do professor no Brasil. Mostra através de uma análise retrospectiva histórica legal, o espaço pedagógico dependente da legislação educacional, e os processos de formação dos professores. Procura estabelecer elos com o contexto-histórico-político e social para uma maior compreensão dos fatos e entender a formação desse profissional na sociedade. Fundamento também meu estudo na formação de profissionais reflexivos, que estejam de acordo com as necessidades do homem para atuar na sociedade. Considero que essa temática possui relevância no quadro político e educacional no Brasil, à medida que se verificou que não haverá ensino de qualidade, nem reformas educativas, nem inovações pedagógicas que substitua uma adequada formação de professores. Concluo que o homem é um ser social que se manifesta no mundo, com outros homens, com a natureza, em sociedade, em constante busca, em um constante aprendizado, que não é estático, que transforma o mundo e é transformado a partir de sua inter-relações.
Safety and Efficacy of Implantable CardioverterDefibrillator During Pregnancy and After Delivery

There are few studies of pregnancy and delivery in patients with an implantable cardioverter-defibrillator (ICD). The purpose of this study was to investigate maternal and fetal outcome in these patients.Six pregnant women with an ICD were retrospectively reviewed. All women underwent implantation of an ICD before pregnancy and delivered at the National Cerebral and Cardiovascular Center. The mean age at pregnancy and the mean follow-up period after ICD implantation were 28±3 years old and 5±3 years, respectively. There was no device-related complication during pregnancy. In 4 women, the number of tachyarrhythmias such as non-sustained ventricular tachycardia increased after the end of the second trimester of pregnancy and anti-arrhythmic medications were gradually increased. No patient received discharges or shocks from the ICD during pregnancy, however, and only one required anti-tachycardia pacing at 27 weeks' gestation. Mean gestational age at delivery was 37±2 weeks and all deliveries were by cesarean section, including 5 as emergency deliveries due to a fetal indication. After delivery, 2 mothers had reduced cardiac function and 1 received an ICD shock for the first time.Pregnancy did not increase the risk of an ICD-related complication under appropriate management. Additional caution might be required in the postpartum period as well as during pregnancy and labor.
Thermal oxidation of cholesterol: Preliminary evaluation of 2-methyl-6-heptanone and 3-methylbutanal as volatile oxidation markers

Cholesterol oxidation in food and model systems is usually monitored by evaluating cholesterol oxidation products, but the analysis is time-consuming and expensive. Therefore, the determination of volatile compounds deriving from cholesterol thermoxidation could be valuable to identify other possible oxidation markers. Cholesterol alone and in the presence of a triacylglycerol mixture (tripalmitin, tristearin, and triolein) were thermoxidized at 170°C for 15min. In both model systems, the total volatile compounds increased three times when oxidation time rose from 5 to 15min. The main classes of volatile compounds were aldehydes, ketones, alcohols and hydrocarbons, displaying a similar behavior in both systems. After 5min of oxidation, 2-methyl-6-heptanone was the main volatile compound, followed by 3-methylpentane, 2,3-dimethyl-1-pentene and 3-methylbutanal. To verify if 2-methyl-6-heptanone could be used as volatile marker of cholesterol oxidation, data were compared with the total cholesterol oxidation products content of each system. A significant correlation between total cholesterol oxidation products content and 2-methyl-6-heptanone amount was found when cholesterol was oxidized alone (r(2)=0.994) and in presence of triacylglycerols (r(2)=0.998). When egg yolk was thermoxidized at 80°C for 6h, 3-methylbutanal was the volatile compound that better explained the oxidative trend in this food system, showing a significant correlation with cholesterol oxidation rate (r=0.91). In conclusion, 2-methyl-6-heptanone and 3-methylbutanal could represent an easy and cheaper strategy for monitoring cholesterol oxidation in model systems and food samples, respectively; however, a deeper investigation on the amount and type of volatile compounds generated from cholesterol oxidation according to the food matrix, should be carried out.
Ubiqutekglide: an advanced electrical weed control device to be integrated with existing agricultural equipment, yielding a zero chemical, organic result at a reduced operational cost

Reduce herbicide usage. Ubiqutek, a UK-based SME built on over 45 years of research presents ‘Glide’ a cost-effective, safe to use and environmentally friendly electrical agricultural weed control solution to be integrated to existing manufacturer’s agricultural platforms.

Benefiting the agricultural market, Glide successfully controls weeds, whilst reducing operational costs and the industries use of herbicides and replacing with an organic process that maintains soil moisture and nutrients and increases crop yield.

Having already developed ‘Touch', a horticultural and amenity electronic weed control device that has been well received by the market, we are well placed to adapt our core technology for the agricultural market. During our Phase 1 feasibility study, we have undertaken significant research to prove commercial and technical feasibility including voice of customer and business planning, and are now embarking on our Phase 2 journey. We have an ambitious growth target to achieve revenue of €37.5m pa by 2023, cumulative net profit of €49.6m, and creating direct employment of 14 FTE. We project the ROI to the EC at 4.8 with breakeven at year 4 post-commercialisation.

Weeds are controlled largely for food production due to their economic significance: the biotic stresses caused by weeds, insects and diseases cause a 31–42% loss in annual food production globally (€454bn). Herbicides account for over a third of the pesticides used in Europe; without herbicides, it is predicted food prices would increase by 40%

With herbicides being legislated against due concerns over their health effects, and given increasing global food requirements, alternative weed control technology is essential in the prevention of unsustainable food inflation. This Horizon 2020 Phase 2 project will allow us to scale up our existing prototype and gain independent and extensive trial results of the Glide technology enabling us to launch to market with the necessary evidence of efficacy
Irb predoctoral fellowship programme: attracting international talent (irb_dream)

IRB Barcelona is a world-class research centre conducting multidisciplinary research of excellence at the unique interface between biology, chemistry and medicine and devoted to understanding fundamental questions about human health and disease. One of the main missions of the Institute is to provide young life scientists with the opportunity to train and conduct research in a unique and multidisciplinary scientific environment. IRB_DREAM is an innovative initiative that will offer 10 four-year fellowships in two separate calls to young and talented researchers to undertake their PhD theses in one of the 27 laboratories at IRB Barcelona. IRB_DREAM seeks to revamp IRB Barcelona’s current PhD Programme by adding an innovative dimension, namely the customization of both the training offer and career development, to its already recognised excellence in research. To implement this enhanced training approach, IRB_DREAM not only counts on a unique training offer carefully designed to promote the 3i aspect but it particularly fosters much valued secondments and other initiatives aimed at enhancing the impact of the results and the career prospects of candidates beyond academia. In this regard, the objectives of IRB_DREAM are fully aligned with IRB Barcelona´s mid-term strategic objectives: to enhance the international visibility of the Institute, to boost translational research by devoting resources to new collaborations with hospitals, and to continue promoting knowledge and new technology transfer to the industrial sector. Fellows will be selected through an independent committee of experts, thereby ensuring transparency and equal treatment of all applications. All of IRB Barcelona’s research programmes will be open to applications from IRB_DREAM fellows. The IRB_DREAM programme will specifically bolster the career development of highly talented scientists and strengthen the biomedical sciences in general.
On chip terahertz frequency combs

The terahertz (THz) portion of the electromagnetic spectrum is the junction between optics and electronics.   THz is a gate to sensing applications and spectroscopy as well as appealing for material inspection,  non-invasive imaging for safety and medical applications and short-range high data rate wireless communication  which are being extended to higher frequencies entering the THz range. Optical frequency combs have dominated the scene of laser physics in the last 10 years revolutionizing many fields of optics from metrology to high precision spectroscopy. Optical frequency combs act as rulers in the frequency domain and are characterized by their perfectly equally spaced and coherent modes. An extremely appealing application of optical frequency combs is the so-called dual-comb spectroscopy where multi-heterodyne detection is performed allowing Fourier transform spectroscopy with high resolution, high sensitivity and no moving parts. 
The objective of this proposal is to create on-chip, self-referenced frequency combs operating in the spectral region from 1.5-5-5 THz.  Two main approaches will be followed: direct generation with THz QC lasers (cryogenically cooled) and room temperature non-linear generation by means of Mid-IR QCL combs.  Such devices will be groundbreaking since they will allow high resolution THz spectroscopy and they will pave the way to high-rate local data transmission and coherent communication. We recently demonstrated octave spanning lasing from a THz QCL: this will constitute the foundation of our efforts. The developed combs will be implemented in the extremely powerful dual-comb scheme with innovative on-chip self-stabilization and detection of the multi-heterodyne signals.  The self-referencing and the independence from an external detector makes the proposed devices disruptive due to their extreme compactness, intrinsic stability and large bandwidth.
Childhood leukemia: overcoming distance between south america and europe regions

Cancer has become an important public health problem worldwide and inequalities in access to malignancies control result in differences in patients’ outcome. Despite the recent improvement of survival rates in childhood leukaemia, there is still a gap in survival between regions, even within well-organized international cooperative groups. Childhood leukaemia care should be addressed from a global point of view, considering not only scientific aspects, the amount of technological and human resources and the current health policies, but also economic, cultural, social, educational and environmental particularities across countries. The aim of CLOSER is to harmonize the levels of care and reduce inequalities in the outcome of childhood leukaemia patients in the Community of Latin American and Caribbean States (CELAC), and in European countries. To do that, we will create a framework of collaborative, multidisciplinary research between CELAC and European regions. From a scientific point of view, we seek to boost a constant exchange of the knowledge on the biology and the technological approaches needed for the diagnosis and follow-up of childhood leukaemia between regions, provide additional resources to perform research and develop new simplified methods to assure a fast translation from bench to bedside. From a social and educative point of view, we will empower patients and families in leukaemia care and encourage the participation of civil society by analysing their particular needs, by promoting advocacy tools, launching a platform to exchange initiatives and experiences in patients care, always acting with the highest respect for the individualities of each country and with the objective to contribute to a better quality of life. To make sure that we approach childhood leukaemia care from an integral perspective, we will include as partners researchers, physicians, patients and families, patients’ organizations, policymakers, small and medium-sized enterprises and civil society representatives. CLOSER will allow a more fluent collaboration worldwide to improve childhood leukaemia control and the quality of life of the patients and their caregivers.
Enhanced mass transport in electrochemical systems for renewable fuels and clean water

To meet the growing demand for green energy carriers and clean water for the next decades, we can use the increasing supply of harvested solar and wind energy to synthesize fuels (hydrogen, syngas, ammonia, etc.) and clean water via electrochemical methods. Electrochemical methods have the advantage of single-step, energy-efficient and low-temperature conversion of chemicals. However, despite developments in electrocatalysts and system design in the past decade, none of the electrochemical methods has grown to a market-leading technology in the energy or water sector because of limitations in process intensification. A boost in electrical current density, without sacrificing energy efficiency, is required to allow large-scale deployment.
This process intensification needs breaking three limitations in mass transport, at three different scales: 1) the diffusion boundary layer (microscale), 2) gas bubble interference (mm-scale) and 3) concentration gradients in the flow compartments bulk. This ERC project will use a multiscale approach to address these three mass transport limitations, and has the objective to understand and enhance mass transport using novel concepts. Diffusion limitations will be addressed via studying suspension electrodes, gas bubbles will be controlled while synergistically disturbing the diffusion boundary layer via pressure swing control, and reactor engineering concepts that are new to the field of electrochemistry are used to mitigate macro-scale concentration gradients. Water electrolysis, CO2 electrolysis and electrodialysis will be used as tool to evaluate these strategies, using fluorescence lifetime imaging (FLIM) and micro particle image velocimetry (μPIV) to observe the local environment at microscale within large-scale systems. This multiscale approach with in-situ measurements of local flow and concentrations will target the fundamental understanding and control of mass transport limitations for universal electrochemical conversion.
Estimation of the methylation pattern distribution from deep sequencing data

Bisulphite sequencing enables the detection of cytosine methylation. The sequence of the methylation states of cytosines on any given read forms a methylation pattern that carries substantially more information than merely studying the average methylation level at individual positions. In order to understand better the complexity of DNA methylation landscapes in biological samples, it is important to study the diversity of these methylation patterns. However, the accurate quantification of methylation patterns is subject to sequencing errors and spurious signals due to incomplete bisulphite conversion of cytosines.A statistical model is developed which accounts for the distribution of DNA methylation patterns at any given locus. The model incorporates the effects of sequencing errors and spurious reads, and enables estimation of the true underlying distribution of methylation patterns.Calculation of the estimated distribution over methylation patterns is implemented in the R Bioconductor package MPFE. Source code and documentation of the package are also available for download at http://bioconductor.org/packages/3.0/bioc/html/MPFE.html .
Angular studies of photoelectrons in innovative research environments

In the ASPIRE project, whose academic and industrial beneficiaries are world leading in their complementary fields of expertise, the overarching research goal is the measurement of photoelectron angular distributions (PADs) in the “molecular frame” (MF) of systems of biological relevance. These MF-PADs can be interpreted as electron diffraction patterns, achieved by “illuminating the molecule from within”, and enable the shapes and motions of individual molecules to be interrogated. Such knowledge is needed for the development of new medicines (the shapes of drug molecules dictate their function) and new materials (efficient solar cells can be constructed if energy dissipation processes in molecules are understood). Progress in this area is highly technologically driven, requiring high repetition rate, short wavelength light sources and fast detectors. The input of private sector beneficiaries is therefore critical to the scientific objectives, as well as to the enhanced training environment. Work packages on advanced light source and detector developments will feed into the overall goal through secondments, regular virtual meetings and face-to-face network meetings. The symbiosis of the developments that will take place in ASPIRE will create a research and training environment that is world-leading and optimally tailored to capitalise, for example, on the investment that has been made in the European XFEL facility. The ESRs will be trained in world-leading laboratories and will benefit from the exchange of best practice among beneficiaries and partners, and from unique training events. ASPIRE will therefore ensure that European research remains competitive in the global market, and that the trained researchers will be uniquely well-placed to contribute to the development of novel instrumentation in the future.