SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Micafungin in a nutshell: state of affairs on the pharmacological and clinical aspects of the novel echinocandin

Micafungin is one of three echinocandin antifungals approved by the US FDA and the European Medicines Agency (EMA). Like all echinocandin antifungals, micafungin inhibits the synthesis of 1,3-β-D-glucan, a main component of the cell wall of many medically important fungi; thus, exerting fungicidal activity against most Candida spp., as well as fungistatic activity against many Aspergillus spp. Micafungin displays linear pharmacokinetics over the therapeutic range with a long half-life, allowing once-daily intravenous administration. Steady state serum concentrations are achieved after 3 days. Since therapeutic concentrations of micafungin are achieved after the administration of a standard dose there is no need for a loading dose. Interactions of micafungin with the cytochrome P450 (CYP3A4) system are marginal; and, consequently, no severe drug–drug interactions have been reported so far. Furthermore, micafungin exhibited favorable profiles for tolerability and safety; no dose-limiting toxicity has been e...
The values of french language and literature in the european middle ages

Two questions about linguistic identity lie at the heart of this project. What is the relation historically between language and
identity in Europe? How are cognate languages demarcated from each other? Normative models of national languages
helped shape Europe. Yet they did not become hegemonic until the 19th century. Indeed, they were imposed (not always
successfully) on a linguistic map of Europe more fluid and complex than most histories of national languages allow. In the
Middle Ages multilingualism was common, as was the use of non-local languages, notably Latin, but also French. This
project undertakes a revaluation of the nature and value of the use of French in Europe during a crucial period, 1100-1450,
less in terms of its cultural prestige (the traditional focus of scholarship) than of its role as a supralocal, transnational
language, particularly in Western Europe and the Eastern Mediterranean. The project fosters collaboration between, and
cuts across, different intellectual and national scholarly traditions, drawing on expertise in codicology, critical theory,
linguistics, literature, and philology; it involves scholars from a range of European countries and North America, entailing
empirical research around a complex and widely disseminated textual tradition vital to medieval understandings of
European history and identity, L’Histoire ancienne jusqu’à César. This case study will ground and stimulate broader
speculative reflection on the two core questions concerning linguistic identity. While the project builds on prior critiques of
the construction of, and investment in, national languages and literary traditions, it has a broad historical scope, and will
offer an innovative, genuinely international perspective, in terms of both its object of study and method. Indeed, its final aim,
through and beyond its consideration of French as a lingua franca, is to interrogate that language’s role in the emergence
of a European identity in the Middle Ages.
Rural tourism promotion system in the Italian-Slovenian Karst

The project proposes the enhancement of tourism supply organized and coordinated at cross-border level, in order to exploit the primary and environmental resources typical of the Karst area. This intervention aims at defining, enhancing and promoting the environmental resources and their tourist, cultural and economic purposes in the crossborder area of the Karst and of Trieste gulf. Extremely interesting geological, environmental and cultural features concentrate in this territory, where the Karst provides a unique environmental system which has no equal in Europe. The meeting between the Karst and the Adriatic sea has brought about the most spectacular landscape as well as interesting and unusual cultural and food-and-wine traditions. This project proposes the enhancement of the Karst plateau as a valuable resource in an integrated vision that ensures natural contiguity at cross-border level. The central elements of this strategy are the economic activities connected with rural tourism and the emerging phenomenon of fish tourism, which match the main features of the local economic development, whilst preserving and enhancing its territory, environment, culture and traditions. Finally, the need for a consistent promotional strategy is emphasized. Although there are several Internet sites that ensure an effective promotion of products or individual territories in the area, there is an overall information promotion deficit with regard to tourist packages enhancing and marketing all historical, cultural and ethnological resources, the sport and recreational opportunities, the naturalistic aspects, wine and food products. For these reasons, a portal devoted to Karst tourism and the creation of integrated tourist packages is going to be set up.
Analysis of multiplicity of Hankel singular values of control systems

Hankel singular values are important input-output invariants of linear control systems, and in this paper we are interested in determining the amount of different values. It is shown that for SISO systems the problem reduces to the analysis of controllability of a certain auxiliary system. For MIMO systems, a method is proposed for constructing the minimal order polynomial such that its roots are equal to the squared Hankel singular values. In the case of maximal multiplicity of the Hankel singular values, the controllability and observability Gramians of the system are proved to be mutually inverse up to a certain scalar multiplier.
XNDDF: Towards a Framework for Flexible Near-Duplicate Document Detection Using Supervised and Unsupervised Learning

Abstract The WWW has witnessed the exponential growth of web documents. People of all walks of life depend on the electronic superhighway, Internet, for retrieving information. Search engines retrieve data. Detecting near duplicate documents and handling them can help search engines to improve performance. In this paper, we proposed two algorithms. The first algorithm is meant for unsupervised probabilistic clustering of documents while the second algorithm is to detect near duplicates that can handle in offline processing of search engines. The clustered documents can avoid unnecessary comparisons while near duplicate detection algorithm involve local feature selection in are given document based on weights assigned to terms. A classifier is built to have supervised learning for discriminating documents. We proposed a framework named eXtensible Near Duplicate Detection Framework (XNDDF) which provides various components that provide room for flexible duplicate detection solutions besides showing offline and online processing required by a search engine. Our future work is to implement the framework components through a prototype application.
Strong-Interaction matter coupled to electroweak probes and dark matter candidates

For decades, the Standard Model of particle physics has successfully
predicted the outcome of experiments probing the laws of nature on the
smallest distances. Its last missing ingredient, the Higgs particle,
was discovered at the Large Hadron Collider at CERN in 2012. A vast
experimental program is now underway to complete its description of weakly interacting particles called neutrinos.

For all its successes, the Standard Model does not provide an
explanation for the nature of dark matter, which is thought to account for a
quarter of the energy in the universe. This project, based on the
`lattice QCD' framework, will enable a more stringent test of the
Standard Model, contribute to narrowing down the list of
dark-matter candidate particles, and reduce uncertainties in neutrino
detection.

The strong interaction, which binds protons and neutrons together to
form atomic nuclei, is described by the sector of the Standard Model
called Quantum Chromodynamics (QCD). The complexity of the strong interaction
is often the limiting factor in testing the Standard Model and in
searching for new fundamental particles and forces. Strong-interaction
matter is also of tremendous intrinsic interest because it exhibits
many emerging phenomena such as spontaneous symmetry breaking,
quantum-relativistic bound states, and a high-temperature `quark-gluon
plasma' phase, to name a few. By replacing space and time by a
lattice, QCD becomes amenable to an ab initio treatment via
large-scale computer simulations.

The subproject of testing `sterile' neutrinos as dark-matter
constituents depends on understanding aspects of hot QCD matter, since
they would have been produced in the early, hot universe. This goal is
thus connected to present-day heavy-ion collision experiments, where
tiny droplets of hot QCD matter are produced in the laboratory.
The role of tetraspanins in plant cell division orientation

How do plant cells decide in which direction to divide? Despite many years of research, we still do not know. This is remarkable, because the selection of the division plane is one of the most important developmental decisions a plant cell has to make throughout its growth. My host lab recently identified the transcriptional pathway that regulates the switch from anticlinal to periclinal cell divisions in the developing Arabidopsis root vascular tissues. However, the executors that translate this transcriptional program into division plane selection remain elusive. By overlap analysis of unpublished bulk- and single-cell-RNA-sequencing datasets generated recently in my host lab, I found that the TETRASPANIN (TET) genes are prime candidates for such executors of cell division orientation. The TET family is conserved throughout eukaryotes, and in animals, TETs act as molecular scaffolds at the plasma membrane and play important roles in the regulation of membrane trafficking, signaling, cell morphogenesis and other vital processes. In contrast, in plants, the molecular functions of TETs are not known, but their putative scaffolding function provides a plausible mechanism for the regulation of cell division orientation through organizing proteins at the cortical division zone. In DIVISION BELL, I will unravel the molecular function of plant TETs and validate their role in the regulation of cell division orientation during root vascular development. To reach this goal, I will combine my expertise in cell biology and bioimaging with state of the art genome-editing techniques, cutting-edge proteomics and top-notch imaging approaches available at the host institute.  This innovative approach will allow me to shed light on the mechanism of cell division orientation regulation by the TETRASPANIN proteins, with the potential to make major conceptual advances in this thrilling field of plant science.
Transition of care: A set of pharmaceutical interventions improves hospital discharge prescriptions from an internal medicine ward

Continuity of care between hospitals and community pharmacies needs to be improved to ensure medication safety. This study aimed to evaluate whether a set of pharmaceutical interventions to prepare hospital discharge facilitates the transition of care.This study took place in the internal medicine ward and in surrounding community pharmacies. The intervention group's patients underwent a set of pharmaceutical interventions during their hospital stay: medication reconciliation at admission, medication review, and discharge planning. The two groups were compared with regards to: number of community pharmacist interventions, time spent on discharge prescriptions, and number of treatment changes.Comparison between the groups showed a much lower (77% lower) number of community pharmacist interventions per discharge prescription in the intervention (n=54 patients) compared to the control group (n=64 patients): 6.9 versus 1.6 interventions, respectively (p<0.0001); less time working on discharge prescriptions; less interventions requiring a telephone call to a hospital physician. The number of medication changes at different steps was also significantly lower in the intervention group: 40% fewer (p<0.0001) changes between hospital admission and discharge, 66% fewer (p<0.0001) between hospital discharge and community pharmacy care, and 25% fewer (p=0.002) between community pharmacy care and care by a general practitioner.An intervention group underwent significantly fewer medication changes in subsequent steps in the transition of care after a set of interventions performed during their hospital stay. Community pharmacists had to perform fewer interventions on discharge prescriptions. Altogether, this improves continuity of care.
BARDACHENKO CYLINDRICAL LOCK

The inventive Bardachenko cylindrical lock relates to locking devices and consists of a body, a rotatable cylinder comprising a pack of locking plates provided with windows for a key and units for mounting said locking plates each of which is provided with a spring and two rest pads for the cylinder and the plate projection. The axis of the channel of the key cylinder and the transversal axes of the plate windows pass through the centre of the rotatable cylinder. The contacting edges of the plate windows are arranges symmetrically with respect to the transversal axes of the windows and the longitudinal dimensions of the plates are shifted with respect to said axes at a distance equal to the size of the blocking ends thereof. The plates together with springs form replaceable code blocks and the units for mounting plates are provided with elements for transmitting the spring efforts to the cylinder rest pads. Said invention makes it possible to reduce the information content of the locking plates of the lock, thereby increasing the secrecy thereof and enabling the lock to re-encoded to any code combination of the key.
Rural–urban differences in cooking practices and exposures in Northern Ghana

Key differences between urban and rural populations can influence the adoption and impacts of new cooking technologies and fuels. We examine these differences among urban and rural households that are part of the REACCTING study in Northern Ghana. While urban and rural populations in the study area all use multiple stoves, the types of stoves and fuels differ, with urban participants more likely to use charcoal and LPG while rural households rely primarily on wood. Further, rural and urban households tend to use different stoves/fuels to cook the same dishes—for example, the staple porridge Tuo Zaafi (TZ) is primarily cooked over wood fires in rural areas and charcoal stoves in urban settings. This suggests that fuel availability and ability to purchase fuel may be a stronger predictor of fuel choice than cultural preferences alone. Ambient concentrations of air pollutants also differ in these two types of areas, with urban areas having pollutant hot spots to which residents can be exposed and rural areas having more homogeneous and lower pollutant concentrations. Further, exposures to carbon monoxide and particulate matter differ in magnitude and in timing between urban and rural study participants, suggesting different behaviors and sources of exposures. The results from this analysis highlight important disparities between urban and rural populations of a single region and imply that such a characterization is needed to successfully implement and assess the impacts of household energy interventions.
A METHOD AND ARRANGEMENT FOR STIRRING INKS

An ink stirring arrangement including a container (1.014), a stirrer (1.012), a motor (1.008), and a motor speed control arrangement (1.004), (1.016), wherein the speed control arrangement is adapted to maintain the speed of stirring below the speed at which turbulence occurs.
Support for the financing of working capital in view of the deterioration of the company’s situation as a result of the COVID-19 pandemic

The project is aimed at supporting the maintenance of the economic activity of a company that has found itself in a situation of sudden shortage due to the outbreak of the COVID-19 pandemic. The applicant shall apply for grants to finance working capital and to cover the costs of running activities for a period of three months.
FAS BLEACHING

The invention relates to lignin-preserving bleaching of lignocellulosic primary fibres produced by the action of sulfites, by means of formamidine sulfinic acid (FAS). The invention also relates to a bleached primary fibrous material consisting of lignocellulosic material produced by the action of sulfites. Primary fibrous material consisting of coniferous wood has a lignin content of at least 15 % in relation to other fibrous materials and a breaking length of at least 7 km at 20°SR, and primary fibrous material consisting of deciduous wood has a lignin content of at least 15% in relation to other fibrous materials and a breaking length of at least 6 km at 30°SR.
An analysis of the energy efficiency of multi-threading on multi-core machines

Multi-core machines are said to provide high performance at low-energy cost via multi-threading. However, obtaining high performance at low-energy cost depends on the optimal usage of the platform. The experimental results show that executing a multi-threaded program with an optimal configuration can lead to significant gains: up to 38.1% reduction in power and 49.72% reduction in total energy. The paper reports on the importance of isolating the energy used by the idle system and considering just the energy used by the multi-threaded program to be able to evaluate the performance of multi-threading accurately. The experimental results also show that the concept that “power consumption is proportional to the cube of the frequency” is not general and does not apply to the scenario investigated. In the experiments presented, the power consumption was rather linear with Intel's mainstream Core Duo Quad microprocessor.
Non-obstructing 3D depth cues influence reach-to-grasp kinematics

It has been demonstrated that both visual feedback and the presence of certain types of non-target objects in the workspace can affect kinematic measures and the trajectory path of the moving hand during reach-to-grasp movements. Yet no study to date has examined the possible effect of providing non-obstructing three-dimensional (3D) depth cues within the workspace and with consistent retinal inputs and whether or not these alter manual prehension movements. Participants performed a series of reach-to-grasp movements in both open- (without visual feedback) and closed-loop (with visual feedback) conditions in the presence of one of three possible 3D depth cues. Here, it is reported that preventing online visual feedback (or not) and the presence of a particular depth cue had a profound effect on kinematic measures for both the reaching and grasping components of manual prehension-despite the fact that the 3D depth cues did not act as a physical obstruction at any point. The depth cues modulated the trajectory of the reaching hand when the target block was located on the left side of the workspace but not on the right. These results are discussed in relation to previous reports and implications for brain-computer interface decoding algorithms are provided.
KVP VETRORESINA DI PARDI CARLO & C. — S.N.C.

SINCE THE BEGINNING OF 2016 KVP HAS DEVELOPED, THANKS TO A DISCRETE MARKET RECOVERY IN THE SECTOR, FURTHER TECHNICAL AND OPERATIONAL SKILLS IN THE FOLLOWING FIELDS: CONSTRUCTION, REPAIR AND MODIFICATION OF MANUFACTURED GOODS FOR NAVAL USE (CONTAINERS, HOTEL SETTINGS, SHOWER TRAYS AND HYGIENE BOXES). CONSTRUCTION, MODIFICATION AND INSTALLATION OF GRP (GLASS) PIPE LINES IN THE ENGINE ROOM. COMPLETE REPAIR AND RECONDITIONING (HULLS AND BLANKETS) OF LIFEBOATS. THIS INCREASE IN ACTIVITY IN THE NAVAL FIELD HAS MADE IT NECESSARY TO BUY (AND PLAN THE PURCHASE) OF NEW AND INNOVATIVE EQUIPMENT, IN ORDER TO BETTER MEET THE QUALITATIVE AND QUANTITATIVE EXPECTATIONS OF THE MARKET. WITHOUT THE INTRODUCTION OF THIS EQUIPMENT THIS NEW WORKING SYSTEM COULD NOT WORK. THEY HAVE THEREFORE BEEN ACQUIRED FURTHER FROM 01/01/2016 TO DATE: 1) INDIVIDUAL WORK EQUIPMENT FOR PERSONNEL (V.FT190 AND FT329 CONSORPTION) ‘10 ROTARY SANDERS’ 04 TRAPA
Public education finance systems in the United States and funding policies for populations with special educational needs.

This research investigates state finance policies for public education using survey methodology. The purpose is to update previous work and the existing knowledge base in the field as well as to provide a compendium of finance and policy options that are used across the states to finance public elementary and secondary schools. Chief state school officers or their designee were queried; data were provided for all 50 states and posted on the web for verification. This article presents the findings together with crosscutting themes including major state apportionment policies for K-12, special student populations, capital outlay provisions and transportation funding.
Military struggle and identity formation in Latin America: race, nation, and community during the liberal period

Significantly advances the discussion about the connections among race, identity, military service, and armed struggle in Latin America during a crucial period of nation-building.--Hendrik Kraay, University of Calgary Sure to become a standard part of the historical literature on the 'national' period in Latin America, these essays give an excellent ground-level view of the process of state formation through war.--Miguel Angel Centeno, author of Blood and Debt Military engagements in Latin America between 1850 and 1950 helped shape emerging nation states and collective consciousness in profound and formative ways. This century, known as the liberal period, was an important time for state formation in the region, as well as for the development of current national borders. This collection of essays aims to assess the role black and indigenous Latin Americans played in the military struggles of this period, and how these efforts contributed to the formation of ideas about race and national identity. While some indigenous people and Afro-Latin Americans came into closer contact with the descendents of colonizers as a result of military service, others turned inward with strengthened ties to their local communities. Many were at times victims of violent conflicts in Latin America, but they surprisingly also shaped the outcome of these wars and employed the wars to advance their own political agendas. The book offers exciting new interpretations and explanations of this key period in Latin American history.
Magnetic properties and magnetization reversal process of L10 FePt/Fe bilayers magnetic thin films

The L1(0) FePt (10 nm)/Fe (delta nm, delta = 0-15) bilayers were fabricated by using magnetron co-sputtering. The L1(0) FePt single layer shows good perpendicular orientation and the in-plane hysteresis loop shows almost a linear behavior. When delta is less than 3 nm, the FePt/Fe bilayers show behaviors like one magnetic phase, the coercivities are close to the values determined by Zeeman energy. When delta is larger than 3 nm, the in-plane hysteresis loops show behaviors similar to a soft magnetic film, the coercivities of the bilayers decreases slowly with the increasing Fe thickness because of confining by the exchange length of FePt layer and Fe layer. The measured coercivities values are optimally fitted by a 1/t(Fe)(1.15) relation. The magnetization reversal process and magnetic interaction were also investigated. (C) 2012 Elsevier B.V. All rights reserved.