SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Prognostıc Value of Increased her2 Expression in Cancers of Pancreas and Biliary Tree

Increased HER2 expression has a prognostic, and predictive value in many solid cancer types, predominantly in breast cancer. However the effects of HER2 on survival from cancers of pancreas, gall bladder, cholangiocellular, and ampullary region are not known. In this study, the effects of increased HER2 expression on these types of cancer have been analyzed. Immunohistochemical HER2 staining was performed in 31 (44.9 %) female, and 38 (55.1 %) male patients with a mean age of 65 ± 10 years, and various parameters, mostly survival rates of patients with pancreas (n = 30; 43.5 %), gall bladder (n = 17; 24.6 %), cholangiocellular (n = 12; 17.4 %), and ampullary region (n = 10; 14.5 %) carcinomas were evaluated. Strong (3 +) membranous staining for HER2 was observed in 2 patients with gall bladder cancers (11.76 % of all gall bladder cancers). In 2.90 % of all cases strong membranous staining (2+ or 3+) was observed. Weak (1+) membranous staining was noted in one (3.33 %) pancreatic, and one cholangiocellular (8.33 %) cancer patient, and in none of the ampullary region patient membranous staining for HER2 was observed. Since only scarce number of patients demonstrated membranous staining for HER2, survival analysis was not performed on these patients. Based on cytoplasmic HER2 staining scores, the patients were divided into weakly (0–3 pts; n = 17 patients; 24.66 %), moderate (4–5 pts; n = 22; 31.88 %), and strongly (6–7 pts; n = 30; 43.46 %) stained groups. Patients whose specimens demonstrated borderline statistical significant (p = 0.052) low staining for HER2 had higher survival rates when compared with other cases. Increased HER2 expression has no prognostic, and predictive value in cancers of pancreas, biliary tract, and ampulla vateri. If HER2 will be evaluated in these types of cancer, membranous, as well as cytoplasmic staining properties should be taken into account.
An erratic dropstone of granodiorite with a water-escape structure from a Weichselian terrace along the River Gauja (NE Latvia)

Abstract A river terrace of the River Gauja (Latvia), built of Weichselian glaciolacustrine deposits, contains a large number of erratic boulders from the Fennoscandian Shield. These erratic boulders include several types of granites and granodiorites. Some of the granodiorites are so strongly weathered that they fall apart into mm-sized grains of individual minerals when it is attempted to take them out of the host sediment. This strongly weathered nature makes them physically comparable to unconsolidated sand. A consequence is that they may be subjected to soft-sediment deformation. The erratic granodiorite boulder under study here is the first described to show such a soft-sediment deformation structure inside: it has been intruded by a water/sediment mixture composed of the underlying silty/sandy material that must have been liquefied, possibly due to pressure exerted by the overburden, or – more likely – by the weight of the concentration of gravel of which the granodiorite boulder forms a part. The overpressurized water/sediment mixture tried to escape upwards through, among a few other places, the strongly weathered granodiorite, forming an escape structure.
Era-Net cofund electric mobility europe

In collaboration with the European Commission and the European Green Vehicles Initiative Association, European countries and regions will set-up an ERA-NET Cofund to further promote electric mobility in Europe. Electric Mobility Europe builds on the experiences, networks and results of Electromobility+ and is designed to take transnational e-mobility research and policy exchange to the next level.

With a two-track approach, the initiative will link research and policy practice in support of electric mobility at the European level.

The first of two pillars of Electric Mobility Europe will fund innovation projects focussing on the application and demonstration of e-mobility with the objective of advancing the mainstreaming of the electrification of mobility in Europe. The initiative will bring together about 30 million EUR for supporting applied innovation projects, including up to 10 million EUR of co-funding provided by the European Commission under Horizon 2020.
In 2016, the initiative will issue a call for project proposals addressing the key areas of electric mobility:
1. System integration (transport, (sub)urban areas)
2. Integration of urban freight and city logistics in the e-mobility
3. Smart Mobility concepts and ICT applications
4. Public transport
5. Consumer behaviour and societal trends

In addition to funding innovation and demonstration projects, the ERA-NET Cofund Electric Mobility Europe will establish a second pillar of activity. The network will provide a platform for cooperation and exchange of information and experiences among participating countries and regions. In this context, know-how will be shared on setting conducive conditions for the development of electric mobility in Europe (e.g. on charging infrastructure). The network will support this by facilitating suitable means of cooperation such as workshops or seminars in order to exchange or coordinate required actions, in attunement with the European Green Vehicle Initiative Association.
Speeding up of genetic algorithm for network topology optimization with use of cumulative updating of network reliability

Network optimization problems in conditions of constraints are NP-hard problems mostly. Genetic Algorithms are applicable solution for network structure optimization and for obtaining good results within acceptable periods of time. In this study we consider the problem of network topology optimization with unreliable communication channels and perfectly reliable nodes in order to obtain the most reliable structure. The problem of reliability computing for such networks is NP-hard so exact algorithm demands enormous computational effort. However, the method based on cumulative updating of lower and upper bounds of network reliability allows to decide the feasibility of a given network without performing exhaustive calculation of reliability. Relying on this technique we propose a new method which speed up network optimization process by the genetic algorithm.
Criterios de elección de centro y segregación escolar en la ciudad de Valencia

El objetivo de este estudio es conocer cuáles son los patrones que intervienen en la elección de centro escolar y detectar los factores sociodemográficos, económicos y de localización que subyacen tras ellos. Para ello, se ha realizado una encuesta a la demanda potencial de los centros públicos que imparten el segundo ciclo de educación infantil en la ciudad de Valencia. Los resultados indican que el principal criterio de elección de centro escolar es la proximidad entre el hogar y el colegio, y que el modo de desplazamiento más utilizado es el peatonal. Sin embargo, los costes de desplazamiento y los medios utilizados están directamente relacionados con las características socioeconómicas de las familias y con la morfología urbana de los barrios en los que se ubican los centros educativos y las residencias de los menores. Además, también existen diferencias de género en el cuidado de los menores y en la tarea de acompañamiento escolar. Por tanto, la elección de centro escolar implica un proceso de segregación que responde a factores demográficos, socioeconómicos y espaciales y que han de ser valorados por los planificadores de la red escolar a fin de garantizar un acceso a la educación pública en condiciones de equidad.
Exploring Clinician Confidence in the Management of Adolescent Menstrual and Reproductive Health Problems

A high incidence of menstrual problems is reported in adolescent girls, with significant attendant morbidity. The majority are likely to be seen and managed by doctors other than specialist gynaecologists. This study aimed to survey the practice of doctors other than gynaecologists, to establish their chosen therapeutic options and confidence levels and to explore knowledge, using clinically challenging scenarios.A questionnaire designed to fulfil the above aims was distributed to a wide range of clinicians across paediatric disciplines and primary care.The questionnaire was returned by 306 clinicians. General practitioners and paediatric endocrinologists were more confident in management and were more likely to self-manage patients (p < 0.01). The oral contraceptive pill was the most frequently chosen first-line therapy by all clinicians, followed by transdermal oestrogen/progesterone, etonorgestrel implant, progesterone-only pills, levonorgestrel-intrauterine system and depot medroxyprogesterone acetate injections. General, community and subspecialist paediatricians were more likely to choose suboptimal management strategies for each of five clinical scenarios.Low confidence levels, suboptimal therapy choices and high referral rates are common among general paediatricians, community paediatricians and subspecialists for adolescents with menstrual and reproductive health concerns. Targeted education for these clinician groups, towards optimizing management for these patients, would enhance care.
Digital transformation of Extra Lux d.o.o.

The operation consists of an investment in the purchase of licensed software B2B, ERP, BI DMS and WMS, which will enable the customer’s experience to be improved and business models upgraded. The operation will also have an impact on raising employees’ digital competences, which will enable an improved culture and greater exploitation of potential.
Sampling protein complex conformational space with native top down mass spectrometry

The main question to be addressed by SPOCk’S MS is how protein complex conformation adapts to local changes, such as processing of polyproteins, protein phosphorylation or conversion of substrates. While labelling strategies combined with mass spectrometry (MS), such as hydrogen deuterium exchange and hydroxyl footprinting, are very versatile in studying protein structure, these techniques are employed on bulk samples averaging over all species present. SPOCk’S MS will remedy these by studying the footprinting and therefore exposed surface area on conformation and mass selected species. Labelling still happens in solution avoiding gas phase associated artefacts. The labelling positions are then read out using newly developed top-down MS technology. Ultra-violet and free-electron lasers will be employed to fragment the protein complexes in the gas phase. In order to achieve the highest possible sequence and thus structural coverage, lasers will be complemented by additional dissociation and separation stages to allow MS^N. SPOCk’S MS will allow sampling conformational space of proteins and protein complexes and especially report about the transient nature of protein interfaces. Constraints derived in MS will be fed into a dedicated software pipeline to derive atomistic models. SPOCk’S MS will be used to study intracellular viral protein complexes, especially coronaviral replication/transcription complexes, which are highly flexible and often resist crystallisation and are barely accessible by conventional structural biology techniques.
Objectives:
- Integrate labelling with complex species selective native MS for time-resolved structural studies
- Combine fragmentation techniques to maximise information content from MS
- Develop software suite to analyse data and model protein complex structures based on MS constraints
- Apply SPOCk’S MS to protein complexes of human pathogenic viruses
The effects of dental wear on impairing mammoth taxonomy: A reappraisal of the Newton mammoth, Bradford County, northeastern Pennsylvania

A mammoth skeleton found at the Newton Site, a kettle lake 15 km southeast of Towanda, Pennsylvania, has been referred to Mammuthus columbi on the basis of its high, narrow skull. However, the specimen's thin enamel (1.3–1.8 mm) and moderately high lamellar frequency (8–8.75 lophs/dm) resemble some specimens of Mammuthus primigenius. Prehistoric range maps show that a Columbian mammoth inhabiting the Towanda area would be a significant outlier from this species' range; however, its location would align well with the range of M. primigenius. To better ascertain the Newton mammoth's identification, we examine herein the effects of dental wear on the morphology of mammoth molars. As mammoth molars wear, the enamel lophs become more broadly spaced and the enamel ridges thicken towards the base of the crown. Thus, an older M. primigenius with extensively worn molars might display thicker enamel and a lower lamellar frequency, and might therefore appear to be a Columbian mammoth on the basis of dental morphology alone. Our results show that the molars of the Newton mammoth are well-worn and are characterized by an enamel thickness and lamellar frequency that aligns better with M. primigenius than with M. columbi. We conclude that one must take into account the effects of dental wear when classifying mammoth species using solely molars.
SUSTAINABLE TEXTILE MEDITERRANEAN NETWORK

Project in brief _x000D_
_x000D_
The Mediterranean textile industry has a longstanding tradition of leadership in terms of innovation, fashion, design and creativity. Despite of the increasingly fierce global competition, textile continues to be an important industrial sector, with an annual turnover of more than € 210 billion and total workforce of 2.3 million. During the last decade, an increasing outsourcing process in textile production has taken place, with some South Mediterranean countries becoming main players. Besides the economic reshaping of the textile industry, environmental sustainability is now a major challenge of the sector: water pollution caused by the discharge of untreated effluents, use of toxic chemicals during processing and energy consumption are common issues associated with textile production. In this framework, SUSTEXNET project will establish a cooperation network among the main stakeholders of the Mediterranean textile industry in order to increase the competitiveness and sustainability of the whole sector._x000D_
_x000D_
Specific objectives _x000D_
_x000D_
• To perform a detailed analysis of the current weaknesses of the textile sector in theMediterranean _x000D_
• To establish synergies among stakeholders involved so as to minimize the environmental impact and maximize the quality and productivity of the textile industry
A Multi-core Parallel Branch-and-Bound Algorithm Using Factorial Number System

Many real-world problems in different industrial and economic fields are permutation combinatorial optimization problems. Solving to optimality large instances of these problems, such as flowshop problem, is a challenge for multi-core computing. This paper proposes a multi-threaded factoradic-based branch-and-bound algorithm to solve permutation combinatorial problems on multi-core processors. The factoradic, called also factorial number system, is a mixed radix numeral system adapted to numbering permutations. In this new parallel algorithm, the B&B is based on a matrix of integers instead of a pool of permutations, and work units exchanged between threads are intervals of factoradics instead of sets of nodes.Compared to a conventional pool-based approach, the obtained results on flowshop instances demonstrate that our new factoradic-based approach, on average, uses about 60 times less memory to store the pool of subproblems, generates about 1.3 times less page faults, waits about 7 times less time to synchronize the access to the pool, requires about 9 times less CPU time to manage this pool, and performs about 30,000 times less context switches.
SCREEN MADE OF RADIATION SHIELDING MATERIAL FOR PROTECTING AN OPERATOR FROM IONISING RADIATION

The invention relates to a screen made of radiation shielding material for protecting an operator from ionising radiation, which screen (1) comprises: (i) a lower part (2) equipped with a front wall (6) made of radiation shielding material, which comprises an upper border (8); (ii) an upper part (3) equipped with a front wall (20) made of a radiation shielding material, at least one part (26) of which is transparent, which front wall (20) comprises a lower border (22); and (iii) at least one passage (27) for the arms of the operator. According to the invention, said front walls (6, 20) of the upper part (3) and of the lower part (2) are separable from each other, said upper part (3) being borne by supporting means (17, 38, 37, 42) allowing the screen to be reversibly manoeuvred either into an active radiation shielding position in which said upper (8) and lower (22) borders are juxtaposed, or into a retracted position in which said upper (8) and lower (22) borders are separated from each other, in order to free a space above said lower part (2).
NOVEL ANTIGEN-BINDING POLYPEPTIDES AND THEIR USES

Novel antigen-binding polypeptides (ABP) and uses thereof are provided.
La politique des grands nombres et les grands nombres de la politique dans la pandémie

The politics of large numbers and the large numbers of politics during the pandemic RÉSUMÉCet article présente les résultats d'une recherche en cours basée sur les statistiques du covid-19 pendant les 18 premiers mois de pandémie au Brésil (de mars 2020 à octobre 2021).Nous avons étudié les relations entre les nombres produits à propos de la maladie et la pandémie elle-même en tant qu'expérience collective.Au cours de l'analyse, nous privilégions trois aspects : l'esthétique, les temporalités et les controverses.Le découpage chronologique proposé considère la forme sous laquelle les chiffres sont présentés et participent à la compréhension de la pandémie, en soulignant l'existence de quatre moments-clés séparant des périodes aux caractéristiques différentes.La politisation des nombres est l'un des aspects mis en évidence, aussi bien dans les rivalités politiques nationales que dans le processus d´attribution d'un sens à la pandémie.À partir du cas brésilien, nous revisitons les expressions « politique des nombres » et « grands nombres » proposées par Alain Desrosières.Au Brésil, les statistiques jouent aujourd'hui un rôle essentiel en tant que langage central du débat public.Ce rôle dépend notamment de la grandeur que les nombres doivent atteindre pour devenir politiquement pertinents.
A first-principles study of methylcyclohexane adsorption on Pt4clusters

The adsorption of methylcyclohexane (MCH) on Pt4 clusters was investigated by means of density functional theory calculations. Various interaction patterns between MCH and Pt4 were constructed and then screened with an extensive structure search for the low-lying isomers of MCH–Pt4 complexes. The optimal adsorbing sites on the Pt4 surface and in MCH were identified. Three Pt4 isomers, rhombus, tetrahedron and square, were found to be competitive in adsorbing MCH molecule, while both the methyl H and the methylene H atoms in MCH are active to interact with Pt4. The structures of MCH and Pt4 clusters change considerably upon adsorption. Three main adsorption patterns were predicted based on an analysis of the electronic structures of the MCH–Pt4 complexes.
PLATELET-DERIVED GROWTH FACTOR ANALOGUES

Novel peptide analogues of platelet-derived growth factor, for use in inhibiting or stimulating growth and/or chemotaxis of cells, e.g. smooth muscle cells. The peptides are selected from any of (I) or linked peptides formed from pairs of the above, or such peptides including a spacer element or cyclised or modified forms thereof.
WELL TREATMENT

Particles containing scale inhibitor may be made by contacting porous ceramic beads with a solution of scale inhibitor, and then drying the beads. If the dried beads are then contacted with a solution containing a high concentration of polyvalent cations, for example 2.5 M calcium ions, and then dried again, then the rate of release of scale inhibitor when the beads are subsequently contacted with water is reduced. Varying the concentration of the polyvalent cation in the range 0.1 to 5.0 M varies the rate at which the inhibitor is subsequently released. The beads may be used as fracture proppants or in a gravel pack so as to suppress scale formation in an oil or gas well.
Ennius and the Architecture of the Annales

Ennius' Annales, which is preserved only in fragments, was hugely influential on Roman literature and culture. This book explores the genesis, in the ancient sources for Ennius' epic and in modern scholarship, of the accounts of the Annales with which we operate today. A series of appendices detail each source's contribution to our record of the poem, and are used to consider how the interests and working methods of the principal sources shape the modern view of the poem and to re-examine the limits imposed and the possibilities offered by this ancient evidence. Dr Elliott challenges standard views of the poem, such as its use of time and the disposition of the gods within it. She argues that the manifest impact of the Annales on the collective Roman psyche results from its innovative promotion of a vision of Rome as the primary focus of the cosmos in all its aspects.
RETURN TO EXPERIENCE AND INITIAL WAGE LEVEL: DO LOW WAGE WORKERS CATCH UP?

SUMMARY This paper estimates the relationship between initial wage and return to experience. We use a Mincer‐like wage model to non‐parametrically estimate this relationship allowing for an unobservable individual permanent effect in wages and unobservable individual return to experience. The relationship between return to experience and unobservable individual ability is negative when conditioning on educational attainment, while the relationship between return to experience and educational attainment is positive. We link our findings to three main theories of wage growth, namely search, unobserved productivity and learning, and human capital. We devise several empirical tests in order to separate the theories. We find evidence in favor of the unobserved productivity and learning model and mixed evidence regarding the search model. We find no evidence in support of the human capital model. Copyright © 2013 John Wiley & Sons, Ltd.