SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Towards the new era of 1.6 tb/s system-in-package transceivers for datacenter applications exploiting wafer-scale co-integration of inp membranes and inp-hbt electronics

IoT, 5G and cloud applications have created a huge growth of datacentre traffic fuelling the market of 400GbE and the ratification of 800GbE and 1.6T standards expected within 2013-2025. Datacentre operators must keep pace with the increasing speeds and to cope with the increasing power consumption required for airflow management and cooling. Moreover, they must address the massive interconnectivity between servers and switches dictated by 5G ultra-low latency applications. 100Gb/s per lane is the next step for the realization of 800GbE modules but this will be the end of pluggables and the start of co-packaged optics with ASICs paving the way to 1.6T and beyond. TWILIGHT aims to bring InP membranes and InP-HBT electronics at unprecedently close distances (<20um) to unleash the speed capabilities of its high performance components and to enable 112Gbaud per lane. Wafer-scale bonding together with high-accuracy assembly and co-packaging concepts, TWILIGHT’s optoelectronic engines will be capable of up to 1.6T capacity. Selective area growth will be exploited to develop C-band and O-band EMLs and UTC photodiodes in combination with echelle gratings on the same system-on-chip platform. Adaptation of the SAG layerstack will be used to develop polarization insensitive SOAs enabling complex functionalities on chip. TWILIGHT will leverage analog bandwidth interleaving for interfacing its transceivers with next generation 112G SERDES and will develop analog (de)multiplexers, >110GHz linear drivers and 100GHz TIAs. TWILIGHT will exploit the PI-SOAs to develop 4x4 and16x16 optical space switches exhibiting nanosecond latency and >50% smaller footprint. The O-band and C-band SiP transceiver demonstrators leverage up to 72% and 74% power consumption savings compared to established technologies and target the datacentre market (2-10km) and DCI (<40km), respectively, with estimated cost 0.89€/Gb/s. Exploitation of TWILIGHT’s technologies is aimed via its industrial partner MLNX.
Hydrogel Composites Containing Carbon Nanobrushes as Tissue Scaffolds

ABSTRACT The objective of this work is to examine the feasibility of electrically conductive hydrogel composites as scaffolds in tissue engineering and tissue regeneration, and to understand the properties of the composites as a growth matrix for clinically relevant cell lines. The composite is comprised of carbon nanobrushes embedded in a biocompatible poloxamer gel. This work assesses the ability of such composite gels to support the growth of fibroblasts and myocytes and eventually serve as a matrix to stimulate wound closure. In such a model, fibroblasts and myocytes are seeded on the hydrogel and bathed in culture medium. The experimental model assesses the ability of fibroblasts and myocytes to grow into and adhere to the gel. The work demonstrates that carbon nanobrushes can be dispersed within poloxamer gels, and that fibroblasts and myocytes can proliferate within homogenously dispersed carbon nanobrush-containing poloxamer gels. This work also examines the effects of carbon nanobrush content on the rheological properties of the poloxamer gel matrix and shows an improvement in several areas in the presence of carbon nanobrushes. Future work will examine the effects of design parameters such as carbon nanobrush content and matrix structure on wound healing, as well as the growth of tendons and other cell lines within the hydrogel composites. This work has relevance for tissue and cellular engineering and tissue regeneration in clinical medicine.
Light-Responsive nanomachines for targeted eradication of bacterial pathogens in localised infections

Antimicrobial resistance (AMR) has been identified as a major threat to mankind in the 21st century. Thus, there is a critical need to develop new antimicrobials and new delivery strategies to preserve the viability of the existing antibiotics. One such strategy is the use of molecular nanomachines (MNMs) for targeted and controlled inactivation of bacterial pathogens. 
REBELLION aims to develop new light responsive MNMs against bacterial pathogens with minimal damage to mammalian tissues. This strategy will provide a therapeutic advantage in terms of efficacy and selectivity compared with current therapeutics while minimizing the potential for the development of AMR.
The proposed research programme combines (1) chemical synthesis of new MNMs, (2) assessment of their efficacy against clinically relevant bacterial pathogens, (3) evaluation of their safety to mammalian cells and (4) in vivo efficacy testing. The results obtained have the potential to lead to an alternative, entirely novel class of antimicrobials (MNMs) and to become a stepping stone towards future clinical trials.
REBELLION is a vital, multidisciplinary and international endeavor that will bring together this fellow’s core expertise in microbial photobiology with (1) antibiotic resistance and infection at IdISBa (beneficiary, Spain), (2) state-of-the-art technology in light-driven antimicrobial therapy, and experience in in vitro and in vivo drug efficacy testing championed by GAMA Therapeutics (host, USA) and (3) expert knowledge in nanomachine synthesis by the Nanotechnology Department of Rice University (co-host, USA). 
I will be trained by top-level scientists and widen my network and competencies through advanced training in nanotechnology, infection, and drug development and testing. This action will catalyze my career into an independent and mature researcher with an eclectic skill set geared toward producing a unique contribution to European excellence in antimicrobial discovery technology.
Microconcrete with partial replacement of Portland cement by fly ash and hydrated lime addition

Abstract The reduction in Portland cement consumption means lower CO 2 emissions. Partial replacement of Portland cement by pozzolans such as fly ash has its limitations due to the quantity of calcium hydroxide generated in the mix. In this work we have studied the contribution of the addition of hydrated lime to Portland cement + fly ash systems. We have also studied several levels of cement replacement, ranging from 15% to 75%. The best mechanical results were obtained replacing 50% of Portland cement by the same amount of fly ash plus the addition of hydrated lime (20% respect to the amount of fly ash). In these systems, an acid-base self-neutralization of the matrix has occurred through a pozzolanic reaction of fly ash with portlandite liberated in the hydration of Portland cement and the added hydrated lime. It has been identified for these mixtures a significant amount of hydrated gehlenite, typical reaction product from rich-alumina pozzolans.
Prevention of fogging and discoloration of multi-pane windows

Fogging and discoloration of multi-pane windows is prevented by sealing the windows with a polymeric seal and by sorbing off-gases evolved by the seal through the use of diatomaceous earth. The diatomaceous earth can be disposed within the volume defined by the panes and the seal, preferably by being disposed within a hollow spacer, or the diatomaceous earth can be mixed with the seal itself. If the diatomaceous earth is mixed with the seal, it can constitute about 1-15 percent by volume of the seal, preferably 1-2 percent by volume. Diatomaceous earth has been found to be especially effective in preventing fogging and discoloration of low emissivity glass.
Successful treatment by chemoradiotherapy for locally advanced cervical low-grade endometrial stromal sarcoma. Case report and review of the literature

We describe the case of a 51-year-old patient with primary low-grade endometrial stromal sarcoma (ESS) of the uterine cervix (FIGO stage IIB). The patient was diagnosed with the neoplasm in June 2009. No synchronous extra-pelvic metastases were found. She was referred to chemoradiotherapy. Three cycles of AP-scheme (doxorubicin 60 mg/m2 and cisplatine 50 mg/m2; one cycle every 28 days) were administrated. External beam irradiation was divided into two steps. In the first step the uterus, both adnexa, parametria, and regional pelvic lymph nodes were irradiated (total dose of 39.6 Gy, 4 fields, 22 fractions of 1.8 Gy per fraction, 5 days/week). Afterwards, only the uterus and both adnexa were irradiated (total dose of 26.0 Gy, 3 fields, 13 fractions of 2.0 Gy per fraction, 5 days/week). As the last part of treatment, intracavitary brachytherapy was administered using a high-dose Ir192 source, with 7 Gy/2.0 cm being delivered to the vaginal surface in 1 fraction (intrauterine applicator 6 cm in diameter with vaginal cylinder 2.6 cm). Treatment was finished in January 2010. The patient, 57 months after the end of treatment, is still under control in our department. No signs of recurrence have been detected since then. We conclude that patients with primary low-grade ESS of the uterine cervix, even when locally advanced, can be successfully treated with combined chemoradiotherapy.
Research needs on biomass characterization to prevent handling problems and hazards in industry

ABSTRACTBiomass comes from different sources and can be used for different purposes, for electricity generation, for transport fuels, for heating, as well as for the manufacturing of bio-based products. Nowadays, the European framework for energy calls for the use of biomass in electricity, heat, and transport (fuels), to reach 20% of all energy use from renewable sources by 2020. Therefore, the use of biomass should roughly have to double. If this is the case, large amounts of biomass will be mobilized and handling problems are expected to grow aligned with the increased use of biomass. Biomass is characterized because it does not flow well, packs easily, it can knit together, it is very dusty, and it is prone to self-heating and self-ignition, among others. If more research is not conducted on the characterization of the behavioral properties of biomasses, the sustainability of supply chains could be then severely affected.
Efficient forestry by precision planning and management for sustainable environment and cost-competitive bio-based industry

EFFORTE draws a red line through critical, cost/benefit driving processes, and environmentally concerns of today´s forestry. Starting with efficient fulfilment of various customer demands the red line goes along efficient utilization of Big Data sources, present knowledge and critical new knowledge foreseen as outcomes from this project.
Technical development and mechanization has been a winning concept for high productivity now emphasizing more gentle methods and just in time deliveries to different industry customers. This is possible to reach if new knowledge, improved methods and technical development are combined with better transfer of information and data from different sources (e.g processes, geo data from LiDAR scanning, other conditions such as weather data etc).These Big Data sources have been available for some years, but it is not until recently that hardware, data communication and merging possibilities enable full potential for a revolution of new applications. 
In the EFFORTE proposal we have identified three main subjects that have specific importance for efficiency, productivity and environmental concern in forest practice. Two of these implies to increasing crucial knowledge and the third, Big Data applications, combines the new knowledge with high resolution information sources into practice increasing efficiency in forest management and the connected value chains. The main objectives of EFFORTE are: i) To develop scientifically firm and techno-economically feasible methodology to predict trafficability prior to forest operations. ii) To increase forest growth and productivity of tree planting and young stand management iii) To develop, customize and pilot modern ‘Big data’ solutions that will increase productivity and decrease negative environmental impact (e.g. soil, water and reduced fuel consumption). By EFFORTE we expect to make difference in efficiency, productivity and sustainability for a growing Bio-based economy in Europe.
Exploring the underlying mechanisms of partial leptin reduction towards a non-invasive obesity therapy

Leptin regulates energy balance by functioning as a “satiety signal”. When identified 26 years ago, expectations were high that leptin therapies could be used for the treatment of obesity. In contrast to the successful use of leptin for treatment of individuals with lipodystrophy and complete leptin deficiency, pharmacological approaches using leptin therapy for the treatment of diet-induced obesity have been widely unsuccessful. Injecting recombinant leptin in the context of obesity, associated with elevated leptin levels, remains ineffective as central neurons become leptin resistant. Interestingly, Scherer et al. recently published a series of findings that encourages for a conceptual shift. They reported that a partial reduction of circulating leptin levels in the obese state prompts an unexpected systemic response resulting in weight loss, reduced food intake, improved glucose and insulin tolerance and increased energy expenditure - all consistent with leptin re-sensitization in central neurons. The systemic physiological benefits of partial leptin reduction have already been demonstrated. The overall goal of this proposal is therefore to determine the underlying molecular mechanisms that are induced by leptin reduction and trigger leptin re-sensitization. Understanding of these conceptual steps should lead us to explore partial leptin reduction as a viable avenue for anti-obesity and anti-diabetic therapy in the near future.  We aim to determine the peripheral effects of leptin reduction using neutralizing leptin antibodies and advanced mouse genetics. Moreover, we will determine downstream signaling events that are affected in peripheral tissues upon leptin depletion using imaging mass cytometry and transcriptional regulation by single cell RNAseq. Finally, we will also determine whether leptin lowering offers synergistic effects with existing weight loss approaches and whether anti-diabetic interventions rely on leptin lowering independent of weight loss.
METHOD AND DEVICE FOR THE PURIFICATION OF EXHAUST GASES

The invention relates to a method for the purification of exhaust gases that contain combustible and NOx-containing exhaust gas components, especially gases originating from lean-mix internal combustion engines, in an exhaust gas converter (1) that comprises at least one heat exchanger (12) with catalysts (15, 33) arranged in the inflow (6) and/or outflow channels (7) thereof. According to the inventive method, exhaust gas (2) flowing into the device is heated up in heat exchange with outflowing exhaust gas and heat is supplied to the exhaust gas. The incoming exhaust gas (2) enters, without deflection and danger of congestion caused by flow obstacles, the inflow channels (6) of the heat exchanger (12) and flows through these channels until it reaches a deflection area (9). Heat in the form of burner exhaust gas is supplied to the exhaust gas by means of an electrically heated burner (19) that is disposed in the deflection area (9) and that is provided with at least one catalyst (31, 32). The burner exhaust gas is admixed to the gas issued from the inflow channels (6), enters the outflow channels (7) together with said gas and is purified from nitrogen oxides by means of a denitrification catalyst (33).
Reconnaissance observations on the buildings damaged by the 2010 Taiwan Kaohsiung earthquake

On March 4, 2010, at 08:18 local time, an earthquake with a magnitude of ML 6.4 hits southern Taiwan. The earthquake occurred in the mountainous area of Kaohsiung County at a depth of 22.64 km. The epicenter was located in the area struck by the 2009 Morakot Typhoon, which destroyed nearly 2,000 houses, leaving 461 people dead and 192 missing. Trapped residents were moved from the affected regions, and the earthquake did not cause any deaths, but injured 96 people. Damage reports were also issued on low-rise and mid-rise reinforced concrete (RC) buildings located 30 km or more from the epicenter. This paper presents the main results of a damage investigation on the largest seismic disaster in a century in the county of Kaohsiung. The focus was on the damage incurred by different types of building structures, including governmental, religious, commercial, and residential buildings. Detailed descriptions are given of the structural configurations as well as the types of damage sustained by five selected buildings. Suggestions are also made to prevent similar damage to low-rise RC buildings in a future disaster.
Engineered topological superconductivity in van der waals heterostructures

Topological matter is a new research focus with great perspectives. These are insulators with an inverted “negative” bandgap and a conducting surface state. While the surface state in a topological insulator (TI) is composed of chiral fermions carrying charge and spin, in topological superconductors it is pinned to zero energy due to particle-hole symmetry and composed of fermions that carry neither charge nor spin. In-stead, they are non-abelian fermions, Majorana and parafermions (MF/PF), that have been proposed for topological quantum computing. Evidence for MFs have been found in nanowires. However, the scaling-up challenge requires a platform in which networks of MFs can be realized. Here, we propose to use graphene-based van der Waals heterostructure for this purpose. The unprecedented versatility is enabled by combining high-mobility graphene with other layered materials, such as transition-metal dichalcogenide, few-layer ferromagnets and superconductors (SCs). This allows to design topological systems, e.g. the quantum spin, anomalous and valley Hall effect, by combining Zeeman energy, spin-orbit and pairing interaction. We will design 2D quantum matter using different approaches, including strain tuning and the dressing of the bandstructure by photon-fields (Floquet TI), and couple it to SCs to induce topological superconductivity. We will use our expertise from studies of Cooper-pair splitters to not only add pairing in a single edge-state, but also between different edge-states, beneficial in obtaining MFs and more exotic quasiparticles. We will apply advanced high-frequency techniques, e.g. emission and noise - in addition to local tunneling spectroscopy - to characterize the in-gap states and to prove their topological nature. We will deliver a versatile technology with which new states of matter can be obtained in a platform which can be engineered in a top-down manner into networks allowing for quantum-state manipulation of MFs and PFs.
A numerical study of iterative substructuring method for finite element analysis of high frequency electromagnetic fields

This paper describes iterative methods for the high frequency electromagnetic analysis using the finite element method of Maxwell equations including displacement current. The conjugate orthogonal conjugate gradient method has been widely used to solve a complex symmetric system. However, the conventional method suffers from oscillating convergence histories in large-scale analysis. In this paper, to solve large-scale complex symmetric systems arising from the formulation of the E method, an iterative substructuring method like the minimal residual method is presented, and the performance of the convergence of the method is evaluated by numerical results. As the result, the proposed method shows a stable convergence behavior and a fast convergence rate compared to other iterative methods.
Regulation and reprogramming of alternative splicing in cellular transformation

Alternative splicing (AS), by affecting nearly 90 percent of human genes, is the major contributor to protein diversity. Mutations that disrupt AS regulatory sequences are a widespread source of human diseases. Various evidences suggest that an AS reprogramming is critical in cell adaptation during cancer development. In spite of increasing interest in the potential oncogenic role of AS, little is known about the molecular mechanisms behind its deregulation during the somatic to the cancer cell transformation. 
Our aim is to contribute to the characterisation of AS reprogramming during the somatic to the proliferative cancer cell transformation using myosin VI as model system. Recent studies from the host lab reported how myosin VI AS modulates its interactome leading to different cellular functions (endocytosis for the long isoform and cell migration for the short one). The lab found that alternative myosin VI splicing is aberrantly regulated in cancer, where exon skipping dictates cell addiction to myosin VIshort for tumour cell migration.In this proposal, we intends to 1) Identify the myosin VI’s alternative splicing regulators and define their role in vitro, 2) identify common splicing-regulated events that occur during the establishment of a fully polarized epithelial architecture and that are possibly deregulated in cancer (AS reprogramming), 3) assess whether cancer stem cells express a specific set of the identified AS genes.Preliminary results revealed that myosin VI isoforms expression can be switch on/off in selective culture conditions. We will take advantage of this beahviour to set up our analysis based on a multidisciplinary approach that includes biochemical, mass spectrometry and cellular biological assayes. The new set of information will gained with this proposal will be instrumental to understanding the molecular mechanism at the basis of AS (de)regulation for myosin VI and more in general for cell transformation during cancer progression.
Asset use and the relevance of fair value measurement: evidence from IAS 41

This study investigates whether asset use influences the relevance of fair value measurement. Specifically, I examine whether fair value is more relevant when it is applied to in-exchange assets than when it is applied to in-use assets. I test the framework on a sample of international firms that adopt International Accounting Standard 41. Using a difference-in-differences approach, I find that earnings information is significantly more relevant when firms measure in-exchange biological assets at fair value, but book value and earnings information is significantly less relevant when firms measure in-use biological assets at fair value. Consistent with these results, in cross-sectional analyses I find that investors discount the fair value of in-use biological assets and their associated unrealized gains and losses relative to the fair value of in-exchange biological assets. At present, the Conceptual Framework provides little guidance on asset measurement, resulting in inconsistencies across measurement standards. Thus, my findings may provide insight to standard setters and those interested in conceptually based asset measurement.