SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Etablierung einer Methode zur Herstellung von adulten pluripotenten Stammzellen

The irreversible loss of cardiomyocytes after myocardial infarction can lead to chronic heart failure. A stem cell-based cell therapy could be a promising approach for organ regeneration. In the present thesis the direct generation of adult pluripotent stem cells from adult cells was investigated. In the first part of this work mesenchymal stem cells (MSCs) of mice and humans were compared to pluripotent embryonic stem cells (ESCs). We analysed pluripotency-specific transcription factors on both mRNA and protein level. We found no comparable expression of pluripotency markers in MSCs and ESCs. However, there was a weak and variable expression of few pluriotency markers, such as Oct4. Furthermore, MSCs showed no capacity of differentiation into cardiac lineage. This indicates that MSCs do not possess pluripotency. Furthermore, the ability of reprogramming of MSCs using ESC-cytoplasm was examined. A method for isolation of the ESC-cytoplasm fragment was established. ESC-cytoplasm fragments could be isolated with a purity of 95%. After fusion of MSCs with ESC-fragments, the derived cells were tested for their pluripotency at the mRNA and protein level. The new derived cells showed no increase of pluripotency. In the second part of this work, unipotent adult spermatogonial stem cells (SSCs) derived from the mouse testis have been investigated under different culture conditions with respect to their pluripotency. We found that adult SSCs responded to culture conditions and could convert into pluripotent stem cells in culture in the presence of leukemia inhibitory factor (LIF) and mouse embryonic fibroblasts (MEFs). The obtained cells showed an ESC-like morphology and strong alkaline phosphatase activity. Furthermore, we found a continuous expression of Oct4, Nanog, Utf1, and Rex1, Esg1 comparable with ESCs at the mRNA level. Additionally, we detected protein expression of Oct4, Nanog, Sox2 and SSEA1 comparable with ESCs. These results suggest that initially unipotent adult SSCs respond to culture conditions and acquire ESC properties under LIF and MEFs culture conditions. We therefore name these cultured cells multipotent adult germline stem cells (maGSCs). Our data show that MSCs have no pluripotency and can not be reprogrammed with single fusion of ESC-cytoplasm. However, adult SSCs respond to culture conditions and acquire pluripotent properties. The successful isolation of pluripotent stem cells from adult SSCs in this work opens new perspectives in the stem cell-based regenerative medicine.
A MONITORING DEVICE

The invention provides a monitoring device suitable for attachment to a surface of a subject, the device comprising a data collector and a processor. The data collector comprises a flexible foil attached to a less flexible socket, where the foil forms a dermal side surface of the data collector for adhesion to a skin surface of a subject to be monitored. To enable communication of electrical signals between the data collector and the processor, the data collector comprises a distribution structure formed as a pattern of an electrically conductive material on an outer surface of a foldable sheet. The foldable sheet forms a layer in the flexible foil and comprising an interface portion which is folded into an aperture in the socket to form a coupling inside the cavity for electrical communication with a matching coupling of the processor when the processor is received in the cavity.
Heating and method for controlling the heating

A heating comprising: a heat pump having an evaporator (14), a compressor (15), a condenser (25) and an expansion means (13) connected by a refrigerant piping (11, 12, 16, 27) in a cycle, at least the evaporator being arranged in an outdoor unit (10); a heating medium piping (21, 31, 34, 35, 35, 22) formed to circulate a heating medium and to flow the heating medium through the condenser exchanging heat between the refrigerant and the heating medium; an outdoor temperature sensor (19) arranged in or at the outdoor unit; and a control configured to set the flow temperature of the heating medium based on the outdoor temperature measured by the sensor and to perform a defrosting mode (B) defrosting the outdoor evaporator, wherein the control is configured to ignore the measurement result of the outdoor temperature sensor during the defrosting mode. Further, the present invention also relates to a corresponding control method.
'Av-Ready' transport models and road infrastructure for the coexistence of automated and conventional vehicles

The mission of CoEXist is to systematically increase the capacity of road authorities of getting ready for the transition
towards a shared road network with increasing levels of automated vehicles (AVs), both in terms of vehicle penetration rates
and levels of automation using the same road network as conventional vehicles (CVs). 

CoEXist will enable mobility stakeholders to get “AV-ready” – which CoEXist defines as conducting transport and infrastructure planning for automated vehicles in the same comprehensive manner as for existing modes such as conventional vehicles, public transport, pedestrians and cyclists, while ensuring continued support for conventional vehicles on the same network.

AV-ready transport and infrastructure planning in cities is a key precondition for fulfilling the promises of AVs to reduce road
space demand and improve traffic efficiency and safety – without it, AVs could simply increase the urban mobility problems.

CoEXist will address three key steps in transport and infrastructure development:
• AV-ready transport modelling: Validated extension of existing microscopic and macroscopic transport models to include
different types of AVs (passenger car/ light-freight vehicle, automation levels).
• AV-ready road infrastructure: Tool to assess the impact of AVs on safety, traffic efficiency and space demand and
development of design guidance for hybrid (AV-/CV-shared) infrastructure.
• AV-ready road authorities: Elaboration of eight use cases in four road authorities (Gothenburg, Helmond, Milton Keynes
and Stuttgart), used to evaluate AV impacts on safety, traffic efficiency and road space requirements (with CoEXist tools)
and making detailed hybrid infrastructure design recommendations.

Due consideration of CEDR’s Transnational Research Programme is shown through the participation of TRL, the coordinator
of the CEDR-funded Dragon project.
Multilayered circuit board for high-speed, differential signals

The present invention provides a circuit board having a differential signal pad pair consisting of a first signal pad and a second signal pad. The first signal pad has (i) a signal via extending therethrough for electrically connecting the first signal pad to a first transmission line of a differential signal path located within the circuit board and (ii) a contact section for receiving a first contact element of a connector. The second signal pad has (i) a signal via extending therethrough for electrically connecting the second signal pad to a second transmission line of the differential signal path and (ii) a contact section for receiving a second contact element of the connector. The distance between the signal via in the first signal pad and the signal via in the second signal pad is greater than the distance between the contact section of the first signal pad and contact section of the second signal pad.
Mise en œuvre sur le marché de technologies mécatroniques innovantes UAV ROBOTICS

Le projet concerne directement un produit destiné aux consommateurs — une tête de film pour des applications professionnelles. Grâce à l’utilisation de solutions mécaniques et de mise en cage exclusives ainsi que d’alliages d’aluminium légers et de fibres de carbone, le poids total de la tête est d’environ 13 kg (presque le double du rapport du poids de l’appareil photo à la masse de l’appareil photo par rapport aux solutions concurrentes). La tête est également équipée d’un système de contrôle à double entraînement unique et exclusif pour chacun des trois axes. La plage d’amortissement des vibrations angulaires atteint 0,02 degrés, ce qui est la valeur obtenue uniquement par les constructions les plus avancées du marché, avec un prix étant un multiple (3 à 5 fois!) de l’appareil proposé. Les activités du projet comprennent: a) la construction d’une équipe d’ingénieurs experts effectuant les tâches de production et de développement de l’équipement, b) la production financée pendant la période piétonne; C) le financement du marketing et des ventes (directement). La mise en œuvre prévue du projet atteint la rentabilité après 1 an d’exploitation de Spóki.
Accroître la compétitivité de l’entreprise en introduisant des outils performants à l’offre

Afin d’adapter l’offre aux attentes toujours plus élevées des clients, la requérante a décidé d’introduire des outils innovants et performants (saw). Il était nécessaire d’acheter des technologies innovantes dans le domaine des scies à haute performance, qui sont utilisées dans de nombreux processus technologiques dans les secteurs du métal, du bois, de la construction, de l’exploitation minière et de nombreuses autres industries. En coopération avec l’Université de technologie de Lublin et l’achat des résultats de recherche b+r, la requérante a l’intention d’acheter les machines et équipements spécialisés nécessaires pour la production et l’entretien de scies à haute performance. En outre, le processus de production produit des déchets, dont certains seront réutilisés pour produire des dents de scie de carbure selon un nouveau procédé innovant. La réutilisation des déchets de carbure aura un impact positif sur la protection de l’environnement. La production de nouvelles dents en carbure pour scies prolongera le temps de travail de l’outil, augmentera la qualité de coupe des matériaux de la pièce, réduira le temps de machine du processus technologique. La nouvelle solution permettra de réduire le bruit pendant le processus de coupe et de sauvegarder la pièce (elle réduira la quantité de détails incomplets. L’introduction de solutions innovantes à l’offre réduira positivement les coûts supportés par les clients dans les processus technologiques et augmentera ainsi les revenus de vente de la requérante.
No walls

Slovenia’s entry into the European Union requires exchanges and cultural-social integration, in order to overcome any physical or mental border, thus fostering the growth of Gorizia and Nova Gorica, providing them with the opportunity to tackle even their most contradictory and uncomfortable aspects. Against this background, the project fosters young people’s aggregation and socialization, with special regard to youth at risk of emargination, by ensuring suitable environments and initiatives to carry out cultural, sport and musical activities whilst setting up a network and preventing young people’s unease. In particular environmental renovation activities are going to be carried out in a historical area - the Basaglia park (former psychiatric hospital in Gorizia); the construction of a music rehearsal studio, a musical video recording studio and a gym is envisaged by the project. These areas - located on the border between Italy and Slovenia - will lay the basis for the development of young people’s activities, thus turning a place of suffering and treatment in a meeting and aggregation centre.
A METHOD OF COMMISSIONING PHYSICAL HVAC DEVICES OF AN HVAC SYSTEM FOR AN HVAC APPLICATION

A method of commissioning physical HVAC devices (Cx) for an HVAC application, the method comprising: communicatively connecting physical HVAC devices (Cx) to a communication bus (40), one physical HVAC device (Cx) being selected as master HVAC device (Cmaster); identifying the physical HVAC devices (Cx) connected to the 5 communication bus (40); determining device type(s) of the physical HVAC devices (Cx); receiving, an application model comprising a device list listing virtual HVAC devices of an HVAC application; generating, by the master HVAC device (Cmaster), a mapping of the physical HVAC devices (Cx) to the virtual HVAC devices using the device type(s) of the physical HVAC devices (Cx) and of the virtual HVAC devices.
Stability of relativistic surfatron acceleration

In this paper we consider the surfatron acceleration of relativistic charged particles by a strong electrostatic wave propagating in a transverse direction relative to the background magnetic field. We investigate how high-frequency fluctuations of the background magnetic field affect the process of the resonant acceleration. We show that the presence of fluctuations leads to particle escape from the surfatron resonance and illustrate that fluctuations of different components of the magnetic field have quite a distinct effect on the energy gained by particles. In the case of the same power density, the strongest effect corresponds to fluctuations of the component directed along the background magnetic field, while the effect of the component along the wave front is substantially weaker. This is more important for particles with a large velocity component along the background magnetic field. We demonstrate that the dynamics of particles can statistically be described in terms of the adiabatic invariant diffusion. We derive the corresponding diffusion equation and compare solutions of that equation with results obtained by the explicit particle tracing.
NETWORK GOVERNANCE AND ENVIRONMENTAL MANAGEMENT: CONFLICT AND COOPERATION

In this article we propose structural preconditions for effective network governance, including network structures that can facilitate effective coordination of action (such as relational and structural embeddedness), and agreement among network actors about goals and actions. We illustrate circumstances in which these preconditions do not seem to be met through a case study of environmental governance of a major water resource – the Swan River in Western Australia. This governance system, since changed by legislation, did not exhibit embeddedness among its constituent organizations, and crucial relations involved contestation, with organizations apparently pursuing different goals. This paper demonstrates how advanced social network methods can be used to analyse a networked governance system. THE ROLE OF NETWORK GOVERNANCE SYSTEMS IN COMPLEX
Computational design of novel functional proteins for immunoengineering

Finely orchestrated protein activities are at the heart of the most fundamental cellular processes. The rational and structure-based design of novel functional proteins holds the promise to revolutionize many important aspects in biology, medicine and biotechnology. Computational protein design has led the way on rational protein engineering, however many of these designed proteins were solely focused on structural accuracy and completely impaired of function. DeNovoImmunoDesign proposes novel computational design strategies centered on the exploration of de novo protein topologies and the use of structural flexibility with the ultimate goal of designing functional proteins. The proposed methodologies aim to solve a prevalent problem in computational design that relates to the lack of optimal design templates for the optimization of function. By expanding beyond the known protein structural space, our approaches represent new paradigms on the design of de novo functional proteins. DeNovoImmunoDesign will leverage our new methodologies to design functional proteins with rational approaches for two crucial biomedical endeavors - vaccine design and cancer immunotherapy. Our strategy for vaccine design is to engineer structure-based epitope-focused immunogens to elicit potent neutralizing antibodies – a requirement for vaccine protection. The underlying basis of cancer immunotherapy is the inhibition of key protein-protein interactions - an arena where rational design is lagging. To meet this central need we will develop innovative approaches to design new protein binders for cancer immunotherapy applications. DeNovoImmunoDesign is a multidisciplinary proposal where computation is intertwined with experimentation (biochemistry, structural biology and immunology). Our unique competences and groundbreaking research have all the components to translate into transformative advances for both basic and applied biology through innovations in rational protein design.
Isotopic labeling for drug innovation

Excessive attrition rates during clinical trials dramatically impact on Drug Discovery and Development (DDD). Absorption, Distribution, Metabolism and Excretion studies carried out on larger series of drug candidates at an earlier stage of the DDD timeline and evaluation of drug efficacy through better assessment of pharmacokinetic/pharmacodynamic relationships, target engagement and receptor occupancy are critically important approaches for de-risking drug innovation since they facilitate early identification of the candidates that display the best in vivo profile. When successfully implemented, this strategy can accelerate the discovery of new therapeutic solutions to existing and emerging diseases, and enhance European pharmaceutical innovation. For implementation, large sets of isotopically-labeled molecules are required and consequently, a huge revival of labeling techniques is urgently needed. Another crucial issue is the scarcity of expert radiochemists in Europe and the lack of first class training programs in this inter-disciplinary field merging chemistry, radiochemistry and medicinal chemistry. The aims of ISOTOPICS are: i) to train the next generation of European chemists with expertise in isotopic labeling and advanced medicinal chemistry through a first-class taught and research training program combined with a highly interactive secondments plan; ii) to develop innovative and general isotopic labeling chemistry and radiochemistry to streamline the synthesis of labeled small-molecule drugs and biologics; iii) to work closely with the European pharmaceutical industry to apply the new labeling methods to drugs currently in development in order to provide solutions to the most pressing problems in drug innovation. This highly interdisciplinary project is expected to have a profound beneficial impact on drug innovation in Europe by providing novel efficient techniques and new experts in the fields of labeling and medicinal chemistries.
The Effect of Interest Rate, Inflation and Government Expenditure on Economic Growth in Indonesia Period of 2005- 2012

This study analyzed the effect of interest rates, inflation rates and government spending on economic growth in Indonesia during 2005 to 2012. By using the method of data analysis panel, overall the independent variables namely interest rate, inflation rate and government spending has a 99% influence on the dependent variable of economic growth. The results of this research is government spending has a positive significant to economic growth. It means that government spending has an effect on economic growth, according to Keynesian theory. Variable interest rate has a significant negative to economic growth, it means that the interest rate effect on economic growth. If the central bank decrease the interest rate, then the investment will be increase, and it means economic growth will also increase. While the rate of inflation also affect economic growth, inflation has a significant positive to economic growth, because the inflation rate in Indonesia is relatively low, it is below 10% and stable. Keywords: interest rate, inflation, government expenditure, economic growth
Melting the earth: the role of magma oceans in defining the earth’s physical and chemical evolution

Catastrophic planetary collisions during the Earth’s first 500 million years provided enough energy to melt its interior, creating planetary-scale volumes of melt, or magma oceans. Their cooling and crystallisation determined the chemistry of the Earth and its long-term habitability. However, we do not know where and how the Earth’s magma oceans crystallised, whether remnants of early magma ocean melts and crystals, or the iron-sulfide liquid that may have separated from them, are still preserved in the mantle today, or what their role is in storing the Earth’s volatiles and rare metals. We also do not know if this residual material remained inert or whether it interacted with mantle melting events during the course of Earth history, potentially transferring its precious cargo to the planet’s surface.

The main barrier to studying magma oceans is that most of the evidence of them on Earth has been erased by the tectonic mixing processes that have operated over the past ~3 billion years. EarthMelt will address this issue by developing novel isotopic tools to study ancient magma ocean events. Iron and calcium stable isotopes show high-pressure phase-specific partitioning effects that can identify the molten and crystalline residues of magma oceans. Copper and platinum stable isotopes can be used to trace the separation of iron-sulfide melt from the silicate mantle and its incorporation in modern and ancient mantle melting regimes. EarthMelt will combine ultra-high precision measurements of these novel isotope systems with experiments simulating the conditions of magma ocean cooling and crystallisation and will apply these isotope tracers to rare samples of the Earth’s interior. 

EarthMelt will determine how the Earth’s magma ocean crystallised and how this influenced the physical structure and chemical composition of our planet, opening up a new approach to the study of magma oceans and their role in controlling terrestrial planet chemistry and habitability.
Knowledge and  Enhancement of Historical Centres and Cultural Landscapes in Alpine Space

The historical pattern and socio-economic system of towns and villages in Alpine space are important both for local culture and European identity  The aims of the project are to protect and enhance that common heritage, improving the knowledge on characteristic features of historical alpine settlements and promoting integrated sustainable policies for interventions, taking into account different aspects of cultural, historical, social, economical and environmental identity, according to the spatial and economic context. Main project activities: 1) cataloguing and cartographic representation (data bases, Geographic Information Systems) of  Alpine Cultural heritage components, based on harmonised methods; 2) defining harmonised analytical methods to evaluate strengths and weakness (SWOT analysis); 3) promoting pro-active policies to protect and enhance cultural heritage components (best practices, guidelines); 4) spreading out positive experiences and supporting integrated policies using information society technologies.
Conductor from flexible material, assembly having such a flexible conductor and method for manufacturing such a conductor

Strip conductor (9) consists of flexible material on which electronic and/or electric components can be arranged. The conductor can be partially embedded in a shape-resistant component (2). Independent claims are also included for: (a) a component for a vehicle consisting of the above strip conductor; and (b) a process for the production of the strip conductor comprising applying electronic and/or electrical components to a flexible strip conductor, placing in an extruding mold, and partially extruding with a plastic.