SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Deconstructing gene regulation through functional dissection of the 3d genome

The three-dimensional organization of the genome inside the nucleus (3DG) is crucial for gene regulation. Although the fundamental building blocks of the 3DG have been identified, how they contribute to gene regulation is incompletely understood. In recent years my lab has started to functionally dissect the 3DG in order to understand the effects on gene expression. The current proposal intends to expand this work and aims to i) broaden the array of proteins that are known organize the 3DG, ii) determine how loss of these proteins affects the 3DG and iii) elucidate how this influences gene expression.
The key to this is to induce changes in the 3DG by acute protein depletion and measuring changes over time. We have preliminary data showing that by depleting regulators of the 3DG we can induce changes within a few hours. We will deplete a range of proteins in pluripotent and differentiated cells to determine their contribution to 3DG organization. Simultaneous characterization of the epigenome and transcriptome will allow us to determine the sequence of changes. In addition, we will perform Thousands of Reporters Integrated in Parallel (TRIP) after perturbation of the 3DG. TRIP reporters all have the same minimal promoter that acts as a sensor for promoter-enhancer (mis)-communication. By combining TRIP with 4C we can measure the changes in the reporter-enhancer interaction landscape. Our data will generate fundamental insight into the parameters that govern the interactions between promoters and regulatory elements, within the context of the 3DG, and their effects on gene expression. Furthermore, it allows us to determine the temporal order of changes in the 3DG, the epigenome and gene expression, which is essential for the establishment of cause-and-effect relationships. Collectively, our data will lead to a better appreciation of how distal and proximal regulatory regions cooperate to establish cell-type specific gene expression programs.
Subsídio de fundo de maneio para a Complex-Service Ewa Janduła — 15568/20

O projeto destina-se a apoiar a empresa no fornecimento de liquidez e no apoio às suas operações quotidianas devido a dificuldades financeiras que ocorreram na empresa em resultado do surto de COVID-19. Assistência financeira prestada com base no regime n.º SA.57015
Development of Intellectual Property Laws and Foreign Direct Investment in Jordan

Intellectual property rights (IPRs) have become inc reasingly important. In particular, increased international trade, global economies, an d developing technologies have played a key role in the development of Intellectual Property laws. T hese factors determine the need for strong IPRs regimes to attract foreign investments in local ent erprises. The same factors also encourage contributions for transfer of technology, and the c reation of new jobs in the host country. Seeing the benefits of foreign investment and the significance of Intellectual Property laws in encouraging these, Jordan has taken important steps to reform i ts legal environment for the protection of intellectual property rights. This paper will exami ne Jordanian Intellectual Property laws concerning the promotion of foreign investment. In particular, the paper will explore the constant need for improvements in legislation, administration, the en forcement of Intellectual Property laws and the necessity to bring them in line with international standards.
Gate rudder system as a retrofit for the next generation propulsion and steering of ships

GATERS proposes the first retrofit application of a novel propulsion and manoeuvring device for ships, called “Gate Rudder System”. It specifically addresses at the call text “to develop and demonstrate to TRL6 and higher innovative, cost-effective retrofit solution for marine shipping to provide substantial improvements regarding environmental impacts and life cycle cost"". Taking advantage of the remarkable fuel saving (a max of 14% in trials and 30% in-service) and excellent manoeuvrability of the gate rudder system, ""GATERS demonstrates significantly reduced emissions from ships particularly within coastal and port areas to challenge and even exceeding the current and future legislative requirements of the IMO and local regulations for emissions"".

GATERS aims to bring together 18 technology experts and prime stakeholders, including the patent holder, to demonstrate and exploit the benefits of this system by two complementary deliverables. First is the retrofit demonstration of the system for the European short sea shipping operations by installing and operating on a target coastal tanker. Second is the concept exploration of this system for the oceangoing shipping operations, including fleet level. Hence to demonstrate if the Gate Rudder System can be the next generation propulsion and steering system for the waterborne transport.

The three-phase work programme of GATERS includes the investigation of the technical challenges and solutions in Phase1. The detailed design and manufacturing of the retrofit system on the target vessel are to be conducted in Phase2. The demonstration of the retrofit technology on the target vessel and its impact assessment comprising other ship types are included in Phase 3. The two deliverables of the projects will be exploited by the Consortium immediately and the European Maritime Industry to follow up through the comprehensive communication, dissemination and exploitation activities supported by the Industry Advisory Board.
SYSTEM FOR FLASHING END JOINTS OF SIDING

A system, flashing apparatus, and associated methods for protecting vertical butt joints in installed siding having locking profiles. The lower profiled edge of the siding is modified proximate the ends during manufacture or in a factory setting to create a modified section configured to mate with a unique piece of factory-produced or pre-made flashing of similar or matching profile. The flashing piece fits with the ends of the adjacent siding boards in a horizontal row and aligns with the profile of the locking edges of vertically adjacent siding boards so the system sheds water effectively and prevents water from penetrating behind the siding. In addition, the factory-modified siding and the pre- manufactured flashing pieces may be supplied as a ready-to-install system that simplifies the siding installation process and shortens the time and cost of installation.
Designing cooperative interaction of automated vehicles with other road users in mixed traffic environments

There is currently a high desire by manufacturers to introduce Automated Vehicles (AVs), SAE level 3 and above, to the market. As AVs are likely to be deployed in mixed traffic, they need to interact safely and efficiently with other (non-equipped) users, including manually driven vehicles, cyclists and pedestrians. Although obstacle detection by AVs is almost flawless, these vehicles cannot communicate their intentions to other road users. This limitation currently reduces their appeal and value to the user. To ensure intuitive and cooperative interaction between the AV and others, and a smooth flow of all traffic, it is essential that there is good means of communication between all actors. The main objective of interACT is to substantially improve this communication and cooperation strategy. interACT will provide an overview of current human-machine interactions in mixed traffic, and increase chances of safe deployment of AVs by developing novel software and HMI hardware components for reliable and user-centric communication between an AV with its users. interACT will: 
1) Use social-psychological models to compile a catalogue of interactions, identifying the main communication needs of road users in current and future traffic scenarios 
2) Improve software algorithms and sensor capabilities for assessing intention recognition and behaviour prediction of surrounding road users 
3) Use a Cooperation and Communication Planning Unit to integrate planning algorithms, providing synchronized and integrated communication protocols 
4) Ensure safety of road users by developing easy-to-verify software for a safety layer, and novel methods for fail-safe trajectory planning. 
Prototypes will be developed and evaluated in multi-actor simulators and two test vehicles, assessing ease-of-use, acceptance, safety and reliability. The impact of this successful communication on reduction of crashes, improvement of traffic flow and acceptance of AVs by society will be investigated.
Local time-average gas holdup comparisons in cold flow fluidized beds with side-air injection

Abstract Fluidized beds are interesting and useful processing systems that are employed in many industries such as processing biomass into biofuels or the coating of pharmaceuticals. Knowledge of fluidized bed hydrodynamics is necessary for the design and scale-up of such devices. This paper describes the local time-average differences of gas holdup in a 10.2 cm and 15.2 cm diameter cold flow fluidized bed that were recorded using 3D X-ray computed tomography. Three different Geldart type B bed materials are studied at various superficial gas velocities and side-air injection flow rates, where the side-air injection simulated the immediate volatilization of a fuel like coal or biomass particles. Variations in side-air injection flow rate have little influence on global bed hydrodynamics, but significantly affects local gas holdup. Axial annular flow dominates over all flow conditions for each material and bed diameter. Wall effects increasingly influence hydrodynamics as bed diameter decreases for all materials.
Water Conservancy and Hydropower Engineering Construction System Brittleness Evaluation Based on Choquest Integral

Water conservancy and hydropower engineering construction system is a typical multi-level complex system and its swarm identity is apparent to brittleness cumulative effect. The brittle sources are interlinked and associated, thus there are topological forms of different brittle sources, which make the relationship of brittleness evaluation cumulative function to be non-linear. In traditional evaluation methods, indicators are usually assumed to be independent, which does not satisfy the non-linear characteristics of water conservancy and hydropower engineering construction system brittleness. Thus, in this paper, weak monotonic of fuzzy measure is used to replace the addition function, brittleness evaluation model of water conservancy and hydropower engineering construction system based on Choquest integral is built.
Making the Functional Organisational Assessment Tool Work for Local Governments in Ghana: Evidence from the Central Region

Effective assessment of the performance of local governments (LGs) enhances responsiveness to the tenets of decentralisation and good governance. Various tools have been used to facilitate the assessment of LGs. However, the responsiveness of these tools to leadership and accountability to citizens remains a challenge. The paper examined how the Functional Organisational Assessment Tool (FOAT) can be made an effective tool for assessing the performance of LGs in the Central Region of Ghana.Mixed-methods approach was used. Multi-stage sampling procedure was used to select a sample of 989 respondents from three local government areas namely: Cape Coast Metropolis (CCM), Effutu Municipality and Asikuma-Odoben-Brakwa(AOB) District. Data were collected from regional, district and community actors using interview schedules and an interview guide. Descriptive statistics and content analysis were used to analyse the data. The study found that the FOAT paid less attention to leadership in the performance assessment of LGs. Mechanisms for holding leaders accountable were not provided in the FOAT and there was very low awareness about FOAT, especially at the community level. The study recommendsthat the FOAT should cover assessment of the leaders in responding to performance requirements and the FOAT administrators should create awareness about FOAT.
Inlet icing protection simulation system

A method and apparatus for generating a flow of heated air in an airfoil model of an inlet of an aircraft engine. Heated air is sent into a duct system associated with the airfoil model of the inlet of the aircraft engine. The heated air is circulated within the airfoil model of the inlet of the aircraft engine using the duct system in a manner that simulates air flowing in the inlet of the aircraft engine.
Common Initiatives to AcKnowledge and valorize tourism potential of the programme area through cinema

Light, Camera, Action!
Ciak project aims to improve and promote the touristic attractiveness of the area of Puglia, Region of Epirus, Region of Ionian Islands and Region of Western Greece through initiatives linked to the audiovisual sector.
Do you know that culture and heritage is a primary motivation for more than 50% of travels?
Thanks to Ciak, the valorisation of the natural and cultural heritage through short movies, documentaries, fiction, animations about the common story of Italy and Greece will increase the awareness on the image of these territories and will support a cross-border creative industry sector. Ciak will enable policymakers from tourism and screen sectors to work together for the first time, closing the knowledge gap in understanding the economic benefits of cross sector collaboration for their regions, implementing new models to promote cultural and natural heritage through audio-visual products. CIAK will implement several cross-borders activities such as:
“Memory” consisting in the executive production of 10 short movies about the common story of Italy and Greece; this task is given to young under-35 directors coming from the involved territories, in order to make them active protagonists of their own lands’ cultural development
“Greece-Apulia Experience”, a screenwriting itinerant workshop between Puglia and Greece involving location scouting activities
Support to several Festivals in the project area focused on cinema to promote the distribution of Greek and Italian movies in each country.
Optimal control of power cost and consumer satisfaction using smart grid intelligent energy management system

This paper investigates the trade off between consumer satisfaction and the electricity cost. Due to forecast error in day ahead low price energy procurement and random realization of real time renewable dc power, it is difficult for an Intelligent Energy Management (IEM) operator to guarantee a satisfaction level to its users. The problem is more complex in the context of hybrid AC/DC smart grid, where AC to DC and DC to AC conversions result in converter losses. Moreover, during peak hours, increased power is required to serve increased load demands which is purchased at higher market rates by the utilities. We demonstrate the optimization problem of minimizing the time average cost of electricity, under the constraints of providing consumers with high satisfaction level. The solution is proposed by introducing load scheduling and hybrid switching control (LSHS) algorithm based on Lyapunov optimization, which is responsible for delivering cost efficient electricity and serving shiftable loads within certain time bound. Our algorithm requires only electricity price values and works without any prior or future knowledge of supply and demand statistics of power.
Modelling in vivo lineage reprogramming of human astrocytes into induced neurons in the adult mouse brain

Studies during last decade have shown that the genetic programs underlying cell identity are plastic even in fully differentiated cells. Direct lineage reprogramming takes advantage of this plasticity to induce cell fate conversions from one cell type into another. The host laboratory is among those who have pioneered successful lineage reprogramming of glial cells into induced functional neurons in vitro and in vivo. These studies have largely focused on murine glia. While there is sparse evidence that also human glia can be reprogrammed into induced neurons, it is unclear whether such lineage conversion can occur within the constraints of the in vivo tissue context by fully integrated mature human glia. In this project I propose an experimental model to study direct lineage reprogramming of human astrocytes into induced neurons at distinct developmental stages within the context of the adult mouse brain in vivo. This model is based on previous findings that show that human astroglial progenitors can integrate into the mouse brain following grafting, maintaining hallmarks that are specific to human astroglia which differ markedly in their complexity from their murine counterparts. Here I will combine this model system with the directed glial differentiation of induced human pluripotent stem cells (hiPSC) and state-of-the-art genome-editing via CRISPR-Cas9 technology. This will enable me to derive transplantable glial progenitors that can be induced to undergo lineage conversion in a humanized in vivo context at distinct maturation stages. With this approach I will obtain important insights into the fundamental question of how the state of maturation and functional integration determines the capacity of human astroglia to undergo lineage conversion into functional neurons in vivo. I expect that the data resulting from this approach will have important implications towards the translation of direct lineage reprogramming into new strategies for brain repair.
A theoretical investigation on the nature of Cl⋯N and Br⋯N halogen bonds in FArX⋯NCY complexes (X=Cl, Br and Y=H, F, Cl, Br, OH, NH2, CH3 and CN)

Abstract A theoretical study was performed to examine intermolecular halogen bonds interactions in F Ar X⋯NCY complexes (X = Cl, Br and Y = H, F, Cl, Br, OH, NH 2 , CH 3 and CN). Examination of the electrostatic potentials of the NCY monomers indicates that the addition of substituents has a large influence upon the most negative electrostatic potential on the surface of the interacting nitrogen and thus modulates these halogen-bonding interactions. The calculated CCSD(T)/aug-cc-pVTZ interaction energies for the complexes span from −0.88 to −3.20 kcal/mol. The nature of Cl⋯N and Br⋯N interactions has been identified in terms of the bond critical point analysis within the quantum theory of atoms in molecules (QTAIM). According to energy decomposition analysis, the stabilities of the F Ar X⋯NCY interactions are predicted to be attributable mainly to electrostatic and polarization effects, while dispersion forces play a smaller role in stabilizing these complexes.
Central European Living Lab for Territorial Innovation

The systemic impact on the economy, the environment and the quality of life in the Central European regions derives from the increase in the “innovation attractiveness” of the Central Europe space, as it develops and articulates the innovation demand coming from its citizens and businesses and sets in place the governance mechanisms to ensure policy coherence and optimise the benefits of single initiatives.

Living Labs (LLs), first experimented at MIT in 2003 “to study people and their interaction with new technologies in a living environment”, have since gained a specifically European dimension based on the co-design of innovative ICT services in local and regional communities. The European Network of Living Labs (ENoLL), launched by the Finnish EU Presidency in December 2006, has become a pillar of the European Innovation Strategy and now counts 212 LLs throughout the EU and abroad.

The project CentraLAB aims to transform Central Europe into a broad-reaching laboratory for innovation, including the social and organisational as well as technological dimensions. CentraLab thus aims to clarify the competitive advantage of a new model of innovation that draws on Central Europe’s deep, common cultural heritage to strengthen territorial cohesion, promote internal integration and enhance competitiveness through reciprocal learning and partnership building. CentraLab is based on a promising approach that has emerged in the arena of ICT under the name “Living Lab”. In this model, technology R&D brings infrastructures into real-life contexts to enable a “co-design” process with end users.

CentraLab adopts a bottom-up approach towards construction of the transnational, multi-level governance structure. Its networking philosophy is action-oriented while organic and open, using the pilot method to achieve a stable, sustainable configuration.
Baixos terraços marinhos associados às transgressões e regressões marinhas holocênicas na Planície Costeira do rio Paraíba do Sul, Rio de Janeiro, Brasil

Áreas costeiras constituem-se como importantes para a análise geomorfológica, uma vez que as formas de relevo resultantes de processos complexos podem ser encontradas e fornecem informações sobre a dinâmica da paisagem em diferentes escalas têmporo-espacial. Diversos estudos oferecem uma visão geral sobre os atributos que influenciam a evolução da planície costeira do rio Paraíba do Sul, estado do Rio de Janeiro, mas a identificação e caracterização dos baixos terraços marinhos permanece pouco explorada. No entanto, diferentes níveis de terraços foram mencionados superficialmente, pelo menos desde o século 20, como registros de antigas posições da linha de costa e despertando muitas discussões. Sendo assim, o presente trabalho identificou e caracterizou diferentes níveis de baixos terraços marinhos e as coberturas superficiais associadas. Para tal, foram utilizadas imagens orbitais e não orbitais, análise granulométrica e Radar de Penetração no Solo (Georradar). A hipótese é que os diferentes níveis destes terraços marinhos podem fornecer insights e contribuir com o avanço do conhecimento sobre a evolução da área durante o Holoceno. Os resultados indicaram a ocorrência de dois níveis destes baixos terraços marinhos (N1 e N2), cujos aspectos morfossedimentares das coberturas superficiais sugerem morfogênese e relações morfodinâmicas associadas às transgressões e regressões marinhas no Holoceno superior. Por fim, espera-se que os resultados possam contribuir com o avanço dos estudos sobre a dinâmica costeira na região e, principalmente, suscitar discussões sobre as influências das pulsações climáticas holocênicas na dinâmica geomorfológica de áreas costeiras.
GAS FLOW CONTROL ASSEMBLY, GAS COCK AND GAS FLOW MANIFOLD

The present invention provides an assembly (1) for controlling supply of gaseous fuel to a gas burner. The assembly (1) includes a manifold (2) of tubular construction (3) defining a passage for supply of gas therethrough. The assembly also includes valve means (4) having one or more orifice (14, 15, 16) for regulating or controlling the volume rate of gas flow (G) through the valve means to a burner. The valve means (4) is combined with the manifold (2) such that the at least one flow regulating orifice (14, 16, 17) is located inside the manifold tube (3). The invention also provides a valve means (4) in the form of a gas cock and a manifold (2) suitable for producing the above assembly (1).