SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Soft-sediment deformation structures from the Diexi paleo-dammed lakes in the upper reaches of the Minjiang River, east Tibet

Abstract The north–south-trending upper reaches of the Minjiang River run along the Longmen Shan–Min Shan fault zone, a zone of abrupt topographic change along the eastern margin of the Tibetan Plateau. Multiple levels of well-preserved soft-sediment deformation structures (seismites) occur in sediments deposited in paleo-dammed lakes in the upper part of the Minjiang River Valley. These deformation structures include liquefied convolute deformation, water-escape structures, flame structures, pseudonodules, ball-and-pillow structures, sedimentary dykes, mud lenses, and large-scale folds. Several kilometers from the barrier bar of the Diexi paleo-dammed lakes, seven deformed structural layers were identified at different heights in late Quaternary stratigraphic sequences near Shawan Village, Maoxian County. Analyses of the deformation structures, landforms, and the structural environment indicate that these deformation structures were caused by earthquakes, slumps, and landslides. OSL (optical stimulated luminescence) and 14C dating of soft-sediment layers from the Shawan site indicate that intense earthquakes occurred during the period 25–20 ka B.P. Therefore, accurate geological dating of deformed features in dammed lake deposits in high mountains and canyons enables the record of moderate- to large-magnitude earthquakes to be extended to the late Pleistocene–Holocene upon the eastern Tibetan Plateau.
Estimation of high-dimensional linear factor models with grouped variables

We introduce a generalization of the approximate factor model that divides the observable variables into groups, allows for arbitrarily strong cross-correlation between the disturbance terms of variables that belong to the same group, and for weak correlation between the disturbances of variables that belong to different groups. We call this model the Grouped Variable Approximate Factor Model. We establish identification, propose an estimation approach based on instrumental variable conditions that hold in the limit, and prove consistency in a dual limit framework. Monte Carlo simulations are used to investigate the performance of the estimator, and the techniques are applied to an analysis of industrial output in the US.
FLEX SEAL FOR GAS TURBINE EXPANSION JOINTS

An expansion joint seal between a gas turbine exhaust duct (12) and an axially adjacent exhaust ductwork comprising plural layers of axially adjacent layers of flexible seal plates (18), each layer comprising a plurality of arcuate segments which together form a 360 DEG annulus; and further wherein the plural layers of flexible seal plates (18) are secured at one end to the gas turbine exhaust duct (12), with opposite ends of the seal plates slidably engaged with at least one surface of the exhaust ductwork.
Preliminary Study of a Model Rotor in Descent

Within a program designed to develop experimental techniques for measuring the trajectory and structure of vortices trailing from the tips of rotor blades, the present preliminary study focuses on a method for quantifying the trajectory of the trailing vortex during descent flight conditions. This study also presents rotor loads and blade surface pressures for a range of tip-path plane angles and Mach numbers. Blade pressures near the leading edge and along the outer radius are compared with data obtained on the same model rotor, but in open jet facilities. A triangulation procedure based on two directable laser-light sheets, each containing an embedded reference, proved effective in defining the spatial coordinates of the trailing vortex. When interrogating a cross section of the flow that contains several trailing vortices, the greatest clarity was found to result when the flow is uniformly seeded. Surface pressure responses during blade-vortex interactions appeared equally sensitive near the leading edge and along the outer portion of the blade, but diminished rapidly as the distance along the blade chord increased. The pressure response was virtually independent of whether the tip-path plane angle was obtained through shaft tilt or cyclic pitch. Although the shape and frequency of the pressure perturbations on the advancing blade during blade-vortex interaction are similar to those obtained in open-jet facilities, the angle of the tip-path plane may need to be lower than the range covered in this study.
CAMPING LINO S.R.L.

LA SOCIETA' ESERCITA ATTIVITA' DI CONDUZIONE DI UN PARCO DI CAMPEGGIO. E' OPERATIVA DAL 18 DICEMBRE 1979 NELLA FORMA DI SOCIETA' A RESPONSABILITA' LIMITATA. ESERCITA LA PROPRIA ATTIVITA' MEDIANTE LA MESSA A DISPOSIZIONE DI CASE MOBILI, PIAZZOLE DI SOSTA, BILOCALI E AREE OPPORTUNAMENTE ATTREZZATE A DISPOSIZIONE DELLA CLIENTELA. IL PROPRIO CAPITALE SOCIALE E' PARI AD EURO 180.800 COME DA VISURA SOCIALE E SVOLGE LA PROPRIA ATTIVITA' AMMINISTRATIVA MEDIANTE UN'ORGANIZZAZIONE INTERNA OPPORTUNAMENTE FORMATA E CARATTERIZZATA DA COMPETENZA E PREPARAZIONE.
Environmental Efficiency of the Fossil Fuels to Electricity Transition in Eastern Siberia Cities

Coal or firewood is still primary heating and domestic cooking energy source in many regions. That seriously threatens millions of people's health and reduces achieving the SDG. About 2.4 million people are suffering and negatively affected by low-pipe stoves emissions in Eastern Siberia. Through modelling, spatial, and quantitative assessments benefits of replacing coal with electricity in private households were carried out. Electricity transition of half of the households reduces benzopyrene hazardous area by 79 - 99 %, PM10 up to 100 %. The results prompt regional authorities to take more decisive actions to remove coal from the private household energy.
Sublethal health effects in laboratory rodents from environmentally relevant exposures to oil sands contaminants

Increasing activity of oil sands extraction and processing in northern Alberta is marked by ongoing controversy about the nature and extent of associated environmental impacts. Bitumen contains a mixture of toxic chemicals, including metals and residual polycyclic aromatic hydrocarbons (PAHs), whose release into the environment poses a distinct risk to the surrounding environment, plus wildlife and human health. In the present study, the authors evaluated several subclinical biomarkers of exposure and effect to mixtures of metals (Pb, Cd, and Hg) and/or PAHs (3 alkylated forms) at environmentally relevant concentrations (100-fold and 10-fold higher than the maximum dissolved concentrations found in snow, to simulate a worst-case scenario), using laboratory mice as a model for future studies of small mammals in the wild. Both metals and alkyl-PAHs exposure were associated with 1) increased relative liver, kidney, and spleen size; 2) alterations in the homeostasis of the antioxidant vitamins A and E in liver; and 3) compromised glutathione redox status in testes, with results also indicating synergistic interactions from co-exposure. The combination of morphometric and oxidative stress biomarkers provide reliable and sensitive measures of the response to contaminant exposure in a mammalian model, suggesting associated physiological costs. Based on the present experimental study, the authors propose that wild small mammals will prove to be valuable sentinel species reflecting sublethal health effects from oil sands-related contaminants. The present study's results also present a basis for the interpretation of future field data.
Combined effect of genetic and environmental factors on the accumulation of proteins in the wheat grain and their relationship to bread-making quality

Bread-making quality of wheat flour is largely determined by the accumulation, concentration and composition of the proteins in the grain, which are influenced by genetic (G) and environment (E) variation and their interactions. We have therefore evaluated the importance of G and E factors and their interactions in determining the accumulation and composition of the proteins in the wheat grain. The cultivar determined development time (CDDT), together with the amount and timing of N application, played a significant role in determining the accumulation and final composition of the wheat grain proteins, explaining 21–59% of the variation. At low temperature, N application both at spike formation and at anthesis explained the highest proportion of variation (36%) in the percentage of sodium dodecyl sulphate (SDS) unextractable polymers in the total amount of polymers (% UPP), while at high temperature CDDT contributed most to the variation in % UPP (20%). The largest contributor to variation in the amount of total SDS extractable proteins (TOTE) was N application at anthesis, both at low and high temperatures (12% and 36%, respectively). Thus, the climate should be considered in recommendations for improving the protein quality and thereby the bread-making quality of wheat. ► Growing temperature is important in choosing strategies to produce bread wheat. ► N application timings were important for protein accumulation at low temperature. ► At high temperature, CDDT increased significantly for protein accumulation.
Ppsc developing topical platelet-rich plasma kit (tprpk) in order to facilitate the further development, adoption and implement. of prp for healthcare with initial specialisation on cell rejuvenation

PpSC and its forthcoming product: Platelet-rich plasma Kit® (TPRPK) is being developed to exploit the massive potential for painless & cost efficient procedures available to patients with various skin conditions and global Facial rejuvenation sector. The key innovations with TPRPK platform are increased lifespan of platelet-rich plasma and none invasive topical application instead of multiple painful injections. In addi-tion, the IP protected PRP storage device and how one feeds into the other. PpSC will initially focus on healing and rejuvenation of the injured tissues along with a calculation of resources reductions achieved through the process. It is envisaged that the PpSC will scale its TPRPK operations across healthcare and cosmetic sectors worldwide in due course.
SUSCEPTIBILITY CORRECTION AND CONTRAST ENCODING WITH SIMULTANEOUSLY REFOCUSED MR IMAGES

A method of refocusing multiple images of the same slice position is used to correct for susceptibility errors which cause signal loss in regions of a single EPI image. Each of the simultaneously recorded images is encoded with a different weighting of rephrasing by a correction gradient pulse, and these simultaneously recorded images are combined into one image which has signal recovery in the regions of high susceptibility phase errors. This pulse sequence provides simultaneous recording of multiple images on the same slice volume to measure velocity of motion with correction of phase shifts from field inhomogeneity and susceptibility. Additional methods provide different MRI improvements.
Apoyo a las pequeñas empresas con un volumen de negocios superior a 500 000 BGN para hacer frente a las consecuencias económicas de la pandemia de COVID-19

Apoyo a las pequeñas empresas con un volumen de negocios superior a 500 000 BGN para hacer frente a las consecuencias económicas de la pandemia de COVID-19
Using Natural Disasters to Study the Effects of Prenatal Maternal Stress on Child Health and Development

Research on the developmental origins of health and disease highlights the plasticity of the human fetus to a host of potential teratogens. Experimental research on laboratory animals has demonstrated a variety of physical and behavioral effects among offspring exposed to prenatal maternal stress (PNMS). However, these studies cannot elucidate the relative effects of the objective stress exposure and the subjective distress in a way that would parallel the stress experience in humans. PNMS research with humans is also limited because there are ethical challenges to designing studies that involve the random assignment of pregnant women to varying levels of independent stressors. Natural disasters present opportunities for natural experiments of the effects of pregnant women's exposure to stress on child development. In this review, we present an overview of the human and animal research on PNMS, and highlight the results of Project Ice Storm which has been following the cognitive, behavioral, motor and physical development of children exposed in utero to the January 1998 Quebec Ice Storm. We have found that both objective degree of exposure to the storm and the mothers' subjective distress have strong and persistent effects on child development, and that these effects are often moderated by the timing of the ice storm in pregnancy and by the child's sex.
Unveiling hidden structure of many-body wave functions of integrable systems via sudden-expansion experiments

In the theory of Bethe-ansatz integrable quantum systems, rapidities play an important role as they are used to specify many-body states, apart from phases. The physical interpretation of rapidities going back to Sutherland is that they are the asymptotic momenta after letting a quantum gas expand into a larger volume making it dilute and noninteracting. We exploit this picture to make a direct connection to quantities that are accessible in sudden-expansion experiments with ultracold quantum gases. By a direct comparison of Bethe-ansatz and time-dependent density matrix renormalization group results, we demonstrate that the expansion velocity of a one-dimensional Fermi-Hubbard model can be predicted from knowing the distribution of occupied rapidities defined by the initial state. Curiously, an approximate Bethe-ansatz solution works well also for the Bose-Hubbard model.
Genomic binding of transcription factors as a function of dna affinity and chromatin.

Transcription factors (TFs) read cis-regulatory information encoded in the genome and by doing so, they establish gene expression patterns. However, TFs must compete with structural chromatin proteins such as nucleosomes for access to DNA, and this may partially explain why only a fraction of their sequence motifs in the genome are actually bound. It is unclear what features discriminate used from unused sites with similar motifs, in vivo, though it is likely that sensitivity of TFs to chromatin is critical for normal gene expression. For example, some TFs have reduced chromatin sensitivity, termed pioneer-factors, and are able to drive differentiation; even these bind a minority of cognate motifs in the genome. Such factors may nevertheless modify chromatin and expose motifs for TFs with higher sensitivity. Alternatively, chromatin proteins and modifications may be intrinsically directed by unidentified DNA sequence features. Though little is known about determines of TF-chromatin sensitivity, it is likely a function of DNA affinity and the ability to recruit chromatin-modifying activity.
The complexity of chromatin/TF interactions necessitates a reductionist approach. The objectives of this project is to gain mechanistic understanding of chromatin-sensitivity and will use established methods to measure binding of ectopic TFs as a function TF properties and chromatin components. I will express exogenous TFs in mammalian cells and compare in vivo binding to in vitro DNA affinity and analyse their chromatin sensitivity (WP1). This setup enables me to modify and profile chromatin before and after expression, which will test the contribution these factors have on TF binding (WP2). Finally, I will test if manipulating the chromatin-modifying activity of an ectopic TF affects binding (WP3). These results will provide mechanistic insight into TF sensitivity to chromatin and should reveal general principles of binding hierarchies and the logic of cis-regulatory regions.
Severe alcoholic hepatitis as precipitant for organ failure and ACLF

Alcoholic hepatitis is the acute deterioration of alcoholic liver disease with rapid onset or worsening of jaundice, which in severe cases, may transition to acute-on-chronic liver failure with extremely high short-term mortality, increasing with the number and severity of hepatic and extra-hepatic organ dysfunction. Diagnosis and treatment are insufficient and challenging, especially due to the complex, multi-factorial and as yet not fully understood pathogenesis. While current management is limited to steroids and best supportive care, debate is ongoing concerning liver transplantation for selected patients, and several novel approaches are under way with mixed results. These drawbacks in disease management together with increasing prevalence in Germany, and generally in Western countries, constitute an unmet need for the healthcare systems. This review tries to summarize the current status of these aspects and provides an overview for pathogenesis, management and potential future treatments.Alkoholhepatitis ist die akute Verschlechterung der alkoholischen Lebererkrankungen mit einem raschen Auftreten oder einer Verschlechterung des Ikterus und in schweren Fällen mit der Transition zum akut-auf-chronischem Leberversagen mit einer horrenden Kurzzeitmortalität, die mit der Anzahl und Schwere der hepatischen und extrahepatischen Organdysfunktion ansteigt. Die Diagnose und Behandlung sind unbefriedigend und herausfordernd, vor allem wegen der komplexen und multifaktoriellen, unzureichend verstandenen Pathogenese. Während das aktuelle Management auf Steroide und “best supportive care” beschränkt ist, wird heftig über die Lebertransplantation für ausgewählte Patienten diskutiert, und mehrere neuere Strategien werden derzeit getestet mit gemischten Ergebnissen. Durch diese Nachteile des Managements zusammen mit der wachsenden Prävalenz in Deutschland und allgemein in westlichen Ländern, bezeichnet man die Alkoholhepatitis als ein „unmet need“ für das Gesundheitssystem. Diese Übersichtsarbeit versucht den aktuellen Stand dieser Aspekte zusammenzufassen und einen Überblick über die Pathogenese, Management und potenzielle zukünftige Therapien widerzugeben.
Ionochem: a new and highly efficient cross membrane drug delivery strategy

Many drugs are designed to target molecules inside cells. Due to the hydrophobic nature of the cell membranes however not all types of drugs can enter the cells in sufficient quantities. Thus large amounts of drug need to be administered which can lead to highly toxic systemic effects for the patient. Furthermore, new classes of therapeutics such as RNA- and DNA-based drugs require advanced delivery techniques to reach their intracellular targets. Ionovation’s proprietary IonoChem technology will provide a novel and highly effective solution to this problem by adding lipohilic “tails” directly to drug molecules at a one-on-one ratio. These “tails” allow drugs to easily pass through the cell membrane. As part of a service offer Ionovation will work with clients to identify the most effective tail for a particular molecule, and will also perform the lipophilization. The IonoChem platform will enable Ionovation GmbH (a manufacturer of experimental set-ups for the analysis of biological membranes) to enter the market for drug delivery technologies, thus creating a new line of business for the company. IonoChem will target the market for drug delivery systems, which was valued at US$151 billion in 2013. Market segments for initial introduction of the technology include RNAi drug delivery (a market worth US $11,7 billion in 2013) and drugs withdrawn from the market (eg Vioxx with 2.5 billion US $ annual global sales). Objectives of the phase I project include analysis of customer needs (pricing, expected turn-around times etc.), refinement of business model (licensing/fee for use model for contract manufacturers vs. service offer with production facilities at Ionovation’s head quarters); search for a suitable contract manufacturer for the phase II activities and the elaboration of a business plan. Phase II objectives include upscaling of the production under GMP conditions, establishment of contact to customers and the qualification of IonoChem in a preclinical setting.
Single-Shot dispersion-scan device for the characterization of ultrashort laser pulses

The idea to be taken to proof of concept is a novel real-time characterization device for short laser pulses, based upon SIngle-Shot dispersion SCAN (SISCAN). The use of femtosecond laser pulses with duration from the single-cycle to the multi-cycle regime, in various applications in research, industry or medicine demands a precise characterization and control of each laser pulse. We propose a device for measuring the intensity and the phase of laser pulses, based upon dispersion scans, i.e. scans of the second harmonic spectrum as a function of dispersion of the fundamental field. The device is able to characterize individual laser pulses and therefore will provide useful realtime feedback to adjustments of any laser system. 

Recently, in the effort to improve the control of light pulses required for our ERC-supported research, two variants of a single-shot d-scan, i.e. one for few-cycle pulses (3-10 fs) and one for longer pulses (15-100 fs) were developed. At the same time, we introduced a new algorithm, drastically reducing the retrieval time. The combination of these developments will allow for measuring individual pulse properties in real-time for very diverse types of lasers.  At the time this application is being sent, two patent applications have been submitted.

Through technical verification (Lund University, Sweden) and business activities (a small company located in Portugal, Sphere Ultrafast Photonics, already commercializing the original, multiple shot version of the device), we will demonstrate the functionality of the concept, the risks will be assessed and minimized and we will prepare to exploit the increased commercial potential, addressing laser manufacturers as well as laser users in both the scientific and commercial spheres.
Combining Master and Apprentice Roles: Potential for Learning in Distributed Manufacturing Networks

The purpose of this paper is to explore possible effects for learning when a manufacturing plant takes a double role, as being both master plant and apprentice plant, in a globally distributed industrialization process. Industrialization is here understood as the process of preparing new products for volume manufacturing. Two research questions are addressed. The first is what characterizes the dual roles. The second concerns how the dual roles affect knowledge integration and learning processes, and whether this arrangement facilitates learning between master and apprentice. Based on a study of a global telecom equipment company, the paper provides insights into some of the challenges and effects of dynamic switching of roles. By separating the network function from the strategic role of the plant, the study identifies four options for learning. The case adds to the literature on learning in manufacturing networks and to previous research on how distributed processes affect innovation capability.