SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
I3 impact innovate invest

The I3 Impact Innovation Invest is a 33 months CSA that addresses the topic  ICT 19 -2015 Technologies for creative industries topic c) Coordination and Support Actions on Convergence and Social Media. I3 will support research results from lab to market making innovation happen. I3 will promote a closer relation between researchers and entrepreneur providing mentorship and tutorship support to researchers and providing access to business angels and investors. The objective is to identify the emerging promising solutions and their feasibility in the Convergence and social media sector within the European research ecosystem. I3 aims to connect them with investors, corporates, institutions and media and with Startup Europe Initiative, in order to help them in accessing the market through selected events and exploitation activities. Living Lab approach will be used to allow business ideas and new technologies to be validated with users and community. I3 will implement a systematic policy review and analysis, applying methods that can effectively be used to solve issues in the domain addressed by the specific ICT19 topic, applying data and evidence methods. A Policy dialogue will be run to identify areas in need of further exploration, in order to advance consensus and bring together key stakeholders from public and private sector, civil society, academia and the media to discuss key policy issues. The dialogues will provide a forum for multi-directional dialogue, strategic coordination for the development of new research agendas, issues on regulatory framework and coordination of policies in Convergence and Social media. I3 will be dedicated to increase the projects outreach and impact bridging the gap between the technologies developed and the access to the market, increasing cooperation within the convergence social media ecosystem and liaising with related Innovation and R&D programmes both at the European international and national levels.
Novel use of exon skipping technology to study structure-function relationship of dystrophin

Duchenne muscular dystrophy (DMD) stems from loss of dystrophin in skeletal and cardiac muscles, which leads to loss of ambulation and cardio-respiratory failure. The most promising treatment that could be applicable to 83% of DMD patients is exon skipping, a technology where the EU is a world leader. Antisense oligonucleotide mediated exon skipping targets DMD pre-mRNA to induce skipping of specific exons and restore the open reading frame. This allows expression of shorter dystrophin proteins that lack domains encoded by the skipped exon(s). A crucial question is how to predict which short dystrophins will be stable and functional. This knowledge is fundamental to select DMD patients that would most benefit from this treatment and identify exons worth targeting via exon skipping. 
The goal of this proposal is to develop a new use of exon skipping technology to rapidly generate mouse models to screen short dystrophins for in vivo stability and functionality in both skeletal and cardiac muscles. This is made possible by a new exon skipping chemistry developed in the UK with unparalleled skipping efficiency in vivo and capable of targeting the heart. I will use this technology to create mouse models for two short dystrophins generated in DMD patients undergoing exon 51 skipping in the current UK clinical trial. I will then biochemically assess their stability and functionality in limb, cardiac and respiratory muscles. Parallel histological studies will assess the presence of muscle pathology with a focus on heart and diaphragm that cannot be sampled in DMD patients. This project will serve as a trampoline for future studies to identify dystrophin exons that when skipped will produce functional proteins with clinical benefits. In addition, this research will generate new fundamental knowledge on dystrophin domains critical for muscle function and may help in the prognosis of DMD patients currently undergoing exon 51 skipping.
Defender el liberalismo con piedras y tanques: Mario Vargas Llosa y la Fundación Internacional para la Libertad

Recientes reflexiones en torno a cómo es posible que el ideario liberal-conservador vuelva a ocupar un lugar central en la dirección de las agendas políticas de la región tras los estallidos populares que impugnaron el llamado consenso de Washington y el surgimiento de diversas experiencias de gobiernos progresistas, abrieron nuevas preguntas al interior del campo de estudios de las derechas alrededor de la novedad (o no) del fenómeno actual. Entendiendo que el término derecha(s) engloba amplios y diversos actores, este trabajo busca abordar la cuestión colocando la atención en los defensores del liberalismo, en particular Mario Vargas Llosa y la Fundación Internacional para la Libertad, la red de think tanks que preside desde 2002. Este trabajo parte del entendimiento de que si bien las derechas actuales son parte de un proceso histórico que tiene un hito clave durante la década de 1980, asociado al thatcherismo, al reaganismo y a las diversas formas en que el programa y filosofía neoliberal fue traducido al escenario latinoamericano, es a partir de los años 2000 que se produce un proceso de condensación de fuerzas e intercambio de recursos materiales y simbólicos que permitieron reactualizar los repertorios en la defensa del programa impugnado. A partir del análisis de las premiaciones y reconocimientos entregados al escritor peruano y del dialogo con los estudios de think tanks, buscamos demostrar que al iniciarse el nuevo milenio la trayectoria de Vargas Llosa inicia un proceso de ampliación de los campos de socialización y reconocimiento que se traduce en la consolidación como referente latinoamericano en la defensa del liberalismo. Entendemos que esta virada se produce luego de su acoplamiento como presidente de la Fundación Internacional para la Libertad al campo de los institutos, fundaciones y centros de pensamiento defensores del liberalismo, en tanto forma colectiva y organizada de disputar en la batalla cultural y de ideas. Este estudio nos induce a pensar que si por un lado no hay novedad orgánica del fenómeno que contornean la ofensiva neoliberal al iniciarse el nuevo milenio; por otro, el cruce entre la conflictividad e impugnación del programa de ‘modernización conservadora’ y el acoplamiento de fuerzas, recursos materiales y simbólicos y de repertorios permiten hablar de una condensación coyuntural que deja de manifiesto la plasticidad estratégica y resiliencia del neoliberalismo.
Intra-governmental coordination for sustainable disaster recovery: A case-study of the Eden District Municipality, South Africa

Abstract Post-disaster coordination is an essential aspect to achieve sustainable disaster recovery. However, to date, little attention has been paid to the subject of coordination in disaster recovery in comparison to response coordination. This study is an investigation into the factors affecting coordination for sustainable disaster recovery. It uses the case-study of Eden district Municipality in South Africa which has been continuously impacted by floods. The paper provides a background on disaster risk management, response and recovery in South Africa to understand the legal instruments available for coordination within the government. The study is structured around the theoretical themes of coordination within the public sector and sustainable disaster recovery. This paper also aims to make suggestions for coordinating sustainable disaster recovery. According to the respondents, the study highlights that (1) much attention paid to response oriented disaster risk management; (2) government departments working in independent silos; and (3) funding and political will are factors that affect coordination for sustainable disaster recovery. Though, the study is limited to a single case study, the results presented may be important considerations in other recovery settings.
La difficile transparence des statistiques épidémiologiques de la COVID-19 ou comment les minorités peinent à exister dans la bataille des chiffres en Amazonie

En Amazonie, l’une des régions du Brésil les plus touchées par l’épidémie de COVID-19, les statistiques épidémiologiques publiées par les autorités brossent un tableau de la crise sanitaire qui interroge, car il ne considère pas ou trop partiellement le sort des populations issues des minorités ethniques et culturelles qui habitent la région. Au cours de la première vague épidémique (de février à juillet 2020), une équipe de 11 chercheurs a recensé et analysé la mobilisation des populations autochtones et quilombolas, et leur appropriation de l’outil statistique, pour apparaître dans les chiffres officiels. En réaction à ces mobilisations, les bulletins épidémiologiques publiés par les États et les communes amazoniennes ont fortement évolué d’un mois sur l’autre, faisant apparaître différentes lectures de la crise sanitaire, ancrées dans les imaginaires et les enjeux de pouvoir des régions amazoniennes. L’analyse met en évidence ce combat, discret mais essentiel, des minorités ethniques du pays, pour que soient actées, par les chiffres et dans les discours, les conséquences de l’épidémie sur leurs populations.
Advanced load sensing technology for aerospace application

The objective of the TecALSens project is the provision of an advanced and validated load sensor for integration in the Smart Integrated Wind Demonstrator and validation in an industrially relevant environment. The project covers the whole process chain taking into consideration specific requirements: from designing of all sensor components through manufacturing of load cell, electronics and sensor body up to validation and verification of its properties and operational behavior. Electronics will be designed and manufactured considering DO-254 specifications; The complete systems will be tested according to DO-160 requirements. In TecALSens a two-step approach will be pursued. After manufacturing, the load sensor will be tested for TRL 4 and TRL 5 compliance. The design phase will support the experimental validation by taking into consideration the environmental conditions. On the basis of these results a critical review and improvement of all steps will be performed. The improved sensor will be tested again following the same procedures. The project will provide a robust and reliable solution based on innovative sensor principle for further application in primary, secondary flight controls and landing gear systems. With this solution  their functional safety can be enhanced. An industrialization path will be defined and verified at each step for further production.
How do horizontal, frictional discontinuities affect reverse fault-propagation folding?

Abstract The development of new reverse faults and related folds is strongly controlled by the mechanical characteristics of the host rocks. In this study we analyze the impact of a specific kind of anisotropy, i.e. thin mechanical and frictional discontinuities, in affecting the development of reverse faults and of the associated folds using physical scaled models. We perform analog modeling introducing one or two initially horizontal, thin discontinuities above an initially blind fault dipping at 30° in one case, and 45° in another, and then compare the results with those obtained from a fully isotropic model. The experimental results show that the occurrence of thin discontinuities affects both the development and the propagation of new faults and the shape of the associated folds. New faults 1) accelerate or decelerate their propagation depending on the location of the tips with respect to the discontinuities, 2) cross the discontinuities at a characteristic angle (∼90°), and 3) produce folds with different shapes, resulting not only from the dip of the new faults but also from their non-linear propagation history. Our results may have direct impact on future kinematic models, especially those aimed to reconstruct the tectonic history of faults that developed in layered rocks or in regions affected by pre-existing faults.
Estudio comparativo técnico y de factibilidad de los estándares de radiodifusión digital terrestre IBOC (canal dentro de banda) y DRM (Radio digital mundial) para la implementación en la ciudad de Loja.

This project is a comparative technical and feasibility research of earthbound digital broadcasting standards IBOC (In-band on the channel), and DRM (Digital radio Mondiale), the development of this research is targeting to establish an appropriate digital broadcasting standard for future deployment in the radio stations in Loja city. Implementation of a digital system would allow radio stations to offer better quality sound, provide to users additional services which are currently offered, and take advantage in a better way the radio spectrum assigned to each one of the radio stations.
Comparative and analytical methods were used in the development of the thesis project, allowing a prior study of the digital broadcasting standards IBOC and DRM, where was analyzed the different architectures, services offered by these digital systems, characteristics and topology of digital systems IBOC and DRM. Subsequently, through a comparative analysis of technical parameters, we proceeded to carry out the assessment of each of the parameters and we determined that the digital standard Digital Radio Mondiale (DRM) is the best to adapt as a digital system in the radio stations in Loja with the 80% compared with 60% of the IBOC system. To complement this thesis work a general scheme of a digitalized radio station was developed for the frequency bands AM and FM with their respective DRM digital equipment.
Cap-covered keyboard apparatus

A cap-covered keyboard apparatus includes plural independent keycaps, wherein each the keycap has a main body and a top surface, and plural cover layers, wherein each the cover layer at least covers the respective top surface of the corresponding main body, wherein each the cover layer has a first surface attached to the top surface and a second surface printed with a character, and the plural cover layers are independent to one another.
e-mobility SMART grid for passengers and last mile freight transports in the Alpine Space

Even though e-mobility diffusion is increasing in Alpine Space (AS) countries, with 66.583 publicly accessible Electric Charging Stations (E-CS) and 594.042 e-vehicles registered in 2018, in order to ease a wider diffusion of e-mobility and its innovative modalities, Public Administrations (PA) should address e-mobility applied to Local Public Transport (LPT) and to City/Last-Mile Freight Logistic (LML) in synergy with private e-mobility and energy integration. Key barriers are represented by the lack of coordination among public and private actors, lack of a participatory approach based on smart territory, an extended smart city logic, and lack of energy and mobility networks integration in the deployment of e-mobility in LPT&LML. Moreover, PA’s competences on energy and smart grid functionalities and digitalization topics should be increased. e-SMART, built on e-MOTICON results, will activate cooperation among PAs and e-mobility and energy operators through LIVING LAB. It will lead, through a ROAD MAP for AS decision makers, to a common approach in development of e-mobility services in LPT & in LML and in planning of adequate E-CS network for entire AS. It will design and test a set of transnational operational instruments for public and private technicians to plan e-mobility infrastructure and services in passengers and freight transports in the framework of smart grid and smart territories: a TOOLKIT. PAs and private sector will benefit from cooperation with research centres & e-mobility users through transnational Living Lab, based on quadruple helix approach. They will collaborate on a common definition of the Road map and on testing appropriate innovative measures of e-mobility applied to LPT&LML, overcoming local approaches. Cooperation model of Living lab will be replicable in all AS countries, Road Map and Toolkit will guide a common transnational approach and method for national, regional and local PA Energy and Mobility Strategic Plans improvement.
A Novel Process Audit for Standardized Perioperative Handoff Protocols

A perioperative handoff protocol provides a standardized delivery of communication during a handoff that occurs from the operating room to the postanestheisa care unit or ICU. The protocol's success is dependent, in part, on its continued proper use over time. A novel process audit was developed to help ensure that a perioperative handoff protocol is used accurately and appropriately over time. The Audit Observation Form is used for the Audit Phase of the process audit, while the Audit Averages Form is used for the Data Analysis Phase. Employing minimal resources and using quantitative methods, the process audit provides the necessary means to evaluate the proper execution of any perioperative handoff protocol.
Catheterless Long-Term Ambulatory Urodynamic Measurement Using a Novel Three-Device System

Long-term urodynamics are required because bladder-emptying disorders are often not clearly revealed by conventional urodynamics. Patients with severe clinical overactive bladder symptoms, for instance, often show normal results. This may be due to the short evaluation time and psychological factors that complicate conventional urodynamics. This study aimed to develop an ambulatory three-component urodynamic measurement system that is easy to operate, registers urodynamic parameters for several days, and has no negative impact on the patient.We developed an intravesical capsule combined with a hand-held device to register voiding desire and micturition, and an alarm pad device that detects urine loss. Recently, the intravesical capsule and its proven function were detailed in the literature. Here, we present detailed in vitro results using a female bladder model. The flexible capsule was C-shaped to minimize the risk of expulsion from the bladder during micturition. Results of biocompatibility evaluation of the intravesical capsule, which is called Wille Capsule (WiCa) are described.The WiCa with an oval nose and a maximum outer diameter of 5.5 mm was easily inserted through a 25-French cystoscope. Removing the WiCa by grasping the nose using the female model with bladder was easily conducted. Expulsion of the WiCa during voiding was avoided through a novel C-shaped device design. Based on in vitro cytotoxicity studies, the capsule is a promising and safe device.Our novel system is an innovative minimally-invasive tool for accurate long-term urodynamic measurement, and does not require inserting a transurethral catheter.
La périurbanisation de la pauvreté : politique de soutien à la propriété et inégalités socio-spatiales en France

Cet article examine le rôle joué par les prêts aidés dans l’accès à la propriété et la ségrégation résidentielle des ménages modestes en France. Au cours de la période 1996-2006, le Prêt à taux zéro a bénéficié à 1,4 million de ménages et constitue la principale mesure pour favoriser l’accession à la propriété. L’analyse s’appuie sur les enquêtes Logement (Insee), les registres administratifs du Prêt à taux zéro (SFGFAS) et des entretiens approfondis auprès d’accédants. Elle compare la position de différentes catégories socioprofessionnelles sur le marché du logement avant et après l’introduction du programme. Dans un contexte de hausse des prix de l’immobilier, on constate que le Prêt à taux zéro a limité l’exclusion des ménages modestes du marché du logement neuf, en particulier en dehors de la région parisienne. Pour autant, les ménages ayant bénéficié d’un Prêt à taux zéro ont eu tendance à s’installer plus souvent dans les zones périurbaines et rurales, caractérisées par une moindre proportion de cadres et de professions intellectuelles supérieures si on les compare aux centres villes. De plus, les entretiens suggèrent que les ménages modestes n’avaient pas une perception claire de l’éloignement géographique généré par l’accession à la propriété, ni de ses conséquences sur leur mode de vie et l’accès à certains services publics (systèmes collectifs de garde d’enfants, transports en commun, lycées, opportunités d’emplois).
NOVEL AMINO ACID DERIVATIVES, METHOD FOR PREPARING SAME, AND THERAPEUTIC USE THEREOF

The invention relates to novel compounds of the formula (I) R1NH-CH(R2)-CH2-S- S-CH2-C(R3)(R4)-CONH-C(R5)(R6)-COOR7, in which R1 is a (acyloxy)alkyl carbamate -C(O)-O-C(R8)(R9)-OC(O)-R10 group; R2 is a hydrocarbon chain, a methylene radical substituted by a heterocycle; R4 is a hydrogen atom and R3 is a phenyl or benzyl radical, a heteroaryl, a methylene group substituted by a heterocycle or R3 and R4 form together a saturated cycle; R5 and R6 are hydrogen, a hydrocarbon chain, a phenyl or benzyl radical or R5 and R6 form together a saturated cycle; R7 is hydrogen, a phenyl or benzyl radical, a group of the formula CR12(R13)C(O)OR14 or OCR12(R13)OC(O)R14 or OCR12(R13)OC(O)OR14. The invention also relates to the use of these compounds as a drug, and to a pharmaceutical composition containing said compounds and a pharmaceutically acceptable carrier. The invention further relates to the combined use of at least one cannabinoid derivative and/or morphine or one derivative thereof and/or Gaba derivatives for enhancing the analgesic and anti-depressive effect of the novel compounds of the formula (I).
Reactivity and assembly of multifunctional, stimuli-responsive encapsulation structures

In biochemical systems, combinations of specialized molecular entities are precisely arranged to give highly complex architectures. Sophisticated functionality, such as the selective chemical transformation of substrates in enzymes, emerges from the interplay of the individual components that are often grouped around a nanoscopic cavity. Control mechanisms based on the cooperative binding of signal substances regulate the enzyme’s action, and complicated feedback loops may apply.
Since the advent of supramolecular chemistry, scientists construct artificial systems with ever increasing complexity and functionality that promise to serve as the basis for future developments in bottom-up nanotechnology with applications in medicine (drug delivery), diagnostics, catalysis, material science and molecular photonics/electronics.
Self-assembly of functional entities with pre-programmed connectivities has produced an impressive line-up of nanoscopic architectures such as coordination cages that recognize and transform molecular substrates. Most of these systems are based on one sort of ligand, joined by one kind of metal ion. My group has reported a number of cages, each equipped with a unique, single function such as chirality, redox-activity, light-switching, allosteric regulation or endohedral binding sites.
While all these mono-functionalized cages contribute to the progress of supramolecular architecture, nature demonstrates that the key to the most sophisticated systems lies in multi-functionalized structures.
As breakthrough strategies for achieving this level of complexity with artificial systems we propose:
1) Heteroleptic coordination of ligands by a [Pd2Ligand4]-platform-specific way of steric fine-tuning
2) Biopolymer-inspired folding of a modular chain of covalently joined building blocks
Combined with our recent achievements in host-guest switching, we aim at adjustable receptors, controllable molecular reaction chambers and multifunctional photo/redox systems