SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Understanding the role of the rainbow trout metagenome on growth and health in aquaculturally farmed fish

Aquaculture is the fastest growing food-producing sector world-wide: >50% of consumed fish are farmed and the increasing human demand for high quality protein will continue. The most important challenge for securing continued development of green aquaculture is sustainable solutions to improve feed efficiency as feed makes up >50% of the total cost for producing a fish. Further, animal protein is increasingly substituting plant based ingredients for fish feed; this has yet unknown effects on related metabolic processes affecting growth and health. Promising solutions for optimizing feed efficiency and fish health stem from recent studies that sequence metagenomes (combined microbial DNA in the host gut) to detail out how the complete gut microbiome (the microbial community in the gut) interacts with metabolic and immunological pathways in human and mice; results that have revolutionized the way we understand how microbes affects human health. Identification of beneficial bacteria holds a huge potential for optimizing feed efficiency and boost immunity in farmed fishes. The aim of this project is to pursue this potential. I will apply a multidisciplinary approach using metagenomics to describe, for the first time, the complete metagenome of the rainbow trout gut. This combined genomic resource will be coupled with carefully planned feeding experiments to identify associations with the host trout gut-microbiota and i) animal vs. plant based diets, ii) genes of the host fish, and iii) individual growth and metabolic traits such as growth rate and fat content of the host trout. Results will yield new knowledge on microbe-host interactions in rainbow trout and may lead to new products (e.g. probiotics and fish feed) enhancing fish health by actively modulating the microbiota. The project will additionally establish trout as a general model for the study of how modulation of the microbiota can give rise to increased health and meat quality in any farmed animal.
A New Additive Homomorphic Encryption based on the co-ACD Problem

We propose an efficient additive homomorphic encryption scheme. In our scheme, an encryption of a message is simply its noisy modular reduction by several different moduli. The security of our scheme relies on the hardness of a new problem, the co-Approximate Common Divisor problem. We analyze its hardness by applying all known attacks and devising dedicated attacks. These analyses are not complete, but give sufficiently plausible evidence for the hardness of this new problem. Our scheme has an advantage in the performance since both of encryption and decryption consist of only several modular multiplications where a modulus is a hard-to-factor integer N or its prime factor, whereas the previous require more expensive modular exponentiations. In fact, our rudimentary implementation demonstrates that our public-key encryption scheme requires about 0.72ms, 4.00μs and 0.40μs for encryption, decryption and an addition of ciphertexts, respectively. It also takes about 40μs to compute an encryption of the mean of 1000 integers of 128-bit from their ciphertexts. To the best of our knowledge, our encryption scheme is the most efficient of those that support an additive homomorphic property. As an application of additive homomorphic encryption, we present how to efficiently evaluate a symmetric polynomial by additionally providing ciphertexts of some powers of messages. We also present a threshold version of our encryption scheme for smooth adoption of our scheme to advanced applications such as private set operations.
Fair pensions and population ageing

Demographic changes in survival rates and age structures require adaptions in public policies. This grant will produce a social benefit by providing policy makers with two kinds of tools that they will need to make these adaptions, fair normal pension ages and consistently up-to-date measures of population ageing that take the changing characteristics of populations into account. An important area of adaption is national pension policy. Recently changes in pension policies have been driven by financial considerations and have aroused a great deal of dissent. One reason for the unhappiness with proposed pension reforms is that they place the burden of reform inequitably. People generally dislike inequitable policies. In this grant, we will produce a detailed case study of equitable pension ages. In the ReAgeing project we dealt with fairness in a very general framework. In this grant, we present an innovative methodology that produces scenarios of equitable normal pension ages using the details of a specific pension system. This grant shows how fairness can enter public policy discussions of ageing.
In the future, new problems with respect to population ageing could arise and new data will certainly become available. In the ReAgeing grant, we produced many new measures of population ageing that took the changing characteristics of populations, such as remaining life expectancy and health into account. Our presentations were based on data that were available at the time of writing. In order for the results of the ReAgeing grant to remain relevant requires a second innovation, a way to keep the new measures of population ageing up-to-date. We do this with two pieces of software that can immediately be updated every time the UN produces a new round of data. We cannot predict exactly how demographic conditions will change. With these pieces of software, we can be sure that we will have the tools to deal with them.
Detection of Pb<sup>2+</sup> based on label-free fluorescence probe

A simple and sensitive detection method for lead ions was developed, based on the G-quadruplex and label-free fluorescence probe. A appropriate G-rich oligonucleotide folded into stable quadruplex structure when mixed with lead in an aqueous solution. Subsequently, single-stranded nucleic acid specific nuclease was added. An oligonucleotide in quadruplex structure is markedly resistant to nuclease digestion . However, G-rich oligonucleotide mixed with other common mono- or divalent ions was completely digested in 5 min under optimized experimental conditions because no quadruplex or less stable quadruplex was formed. Finally, a positively charged pyrene probe was mixed with oligonucleotide in lead. Electrostatic interactions between oligonucleotide (a polyanion) and the probe induced aggregation of the probe, which in turn induced strong pyrene excimer emission. The intensity of the induced excimer emission was directly proportional to the amount of lead added. The detection limit of our method was 500 nM.
INFLUENCE OF N, N-DIMETHYLACETAMID ON THE THERMAL AND MECHANICAL PROPERTIES OF POLYMER-FILLED WOOD

Mercerized wood species were impregnated with N, N-dimethylacetamid. The FT-IR showed enhanced absorption at 1419 cm-1(-C-/CH3), and the 1267 cm-1 (-N-/ CH3) stretching band confirmed the polymerization reaction. Differential scanning calorimetric analysis indicated that the decomposition temperature of polymer-filled wood gives a higher thermal stability compared to the raw material. Polymer-filled wood yielded higher MOE and MOR compared to the untreated wood. The Young’s modulus of Xylopia Spp Artocarpus Rigidus and Eugenia Spp were significantly different between raw wood and WPC. The increase in the stiffness and the thermal stability of the composites increased due to the crystallinity of polymer-filled wood as indicated by XRD analysis.
Concha HERRERO CARRETERO, Álvaro MOLINA y Jesusa VEGA, «La decoración ideada por F. Grognard para los apartamentos de la duquesa de Alba en el Palacio de Buenavista», Madrid, Casa de Velázquez / Ministerio de Defensa, 2020, 470 págs. + 55 ilustraciones

Sin resumen.
Not another history of platonism. the role of aristotle's criticisms of plato in the development of ancient platonism

The conventional historiography of ancient Platonism follows patterns that ultimately go back to Antiquity itself. While these traditional doxographical accounts are not per se inaccurate, they do overlook continuities across different phases of this thousand-year history as well as some unexpected discontinuities. The reason for these shortcomings lies in the fact that certain philosophical debates are being ignored. Some omissions could be detected by searching for the philosophical reasons explaining doctrinal developments. 
This project chooses an unorthodox approach in that it does not try to reflect the issues emphasised in the sources, but instead selects one particular angle of approach: Aristotle’s critical discussion of Platonic views. By analysing Platonic responses to Aristotle’s criticisms and using these as a heuristic tool, the project pursues a twofold aim: to uncover debates that have hitherto not been picked up in scholarship; and to examine the philosophical reasons for doctrinal varieties and developments. The research hypothesis guiding this project is that Aristotle’s criticism of Platonic philosophy was a driving force for many developments in Platonism. 
The aims of the project can only be achieved through a large-scale investigation spanning the entire history of Platonism, searching for Platonic responses in all relevant philosophical domains. Since scholarship has been selective in its choice of topics, it cannot be predicted whether we can find sufficient traces of pertinent discussions in all subdomains. Despite the methodological difficulties and the uncertainty of the results the project is more than worth pursuing, as the pay-off is highly significant: it will radically change the way in which we understand the history of Platonism and add a whole new dimension to our historiographical accounts. If successful, it will uncover new debates and allow us to understand philosophical justifications for many philosophical developments.
Platform of bioeconomy era-net actions

PLATFORM brings together ERA-NETs in the area of the bioeconomy. The current proposal will continue and expand the work of FP7 PLATFORM (2012-2014) with the following objectives: to further increase collaboration among actors, to foster inclusiveness, to increase capacities for efficient and effective ERA-NETs, and to inform research policy making. 

FP7 PLATFORM organised inspiring annual events, dedicated workshops, a master class for call managers, fruitful two-way interaction with the Commission, the EIP AGRI and with the BBI-JU, and produced a comprehensive book about the bioeconomy ERA-NETs and their activities. Surveys, analysis and events also engaged ERA-NETs from neighbouring themes with bioeconomy relevance, JPIs Oceans and FACCE, SCAR WGs, and self-sustained ERA-NETs. 

PLATFORM2 will build on these activities and will further strengthen mutual learning, maximise synergies and increase coordination. PLATFORM2 will expand the network to new ERA-NET actions (Cofund), to more JPIs and will also seek stronger interaction with SCAR. On the website, a searchable database on bioeconomy ERA-NET joint calls will be constructed, including statistics and impact assessments, such as on leverage. Data may flow into other data repositories, e.g. an EIP Agri database on projects in the area of agriculture. A World Café workshop is scheduled to ponder new, sustainable and alternative models for cooperation between public research programmes. PLATFORM2 will make an inventory of alignment actions taken by ERA-NETs. The series of Annual Events will be continued and enable actors to discuss emerging cooperation needs, opportunities and tools. PLATFORM2 will foster inclusiveness in all its work, in particular by a master class directed at new Member States and sessions at the Annual Events on improving both involvement and performance. Capacities will be increased by sharing experience and by way of master classes on planning and managing (Cofund) calls, as well as through evaluation and monitoring of ERA-NETs. The reflections and recommendations will be summarised in policy briefs.
Typhoid fever - Its prediction without Blood culture

To diagnose typhoid fever on clijnical ground without blood culture, a study was conducted in Medcial A unit LRH, Peshawar on 25 patients with typhoid fever. 24(96%) blood cultures yielded the growth of salmonella typhi and 1 (4%)of S Parathphi A. Fever for more than 7 days was noted in 20 (80%) aptietns. Toxic look and coated lips were present in 17 days was cough with few basal crackles were recorded on 15(60%) cases. Spleen was enlarged in 15(60%) and pain abdomen with diarrhea were complained by 14(56%) patients. The TO and AO titres of the widal test were raised to > 1/320 in 16 (64%) cases. Clinical diagnosis of typhoid fever was suggested by the following 6 events: duration of fever for more than 7 days, toxic look and coated lips, dry cough with few crackles, soft spenomegally, pain abdomen with diarrhea and a positive widal test at screening dilution of > 1 / 320.
Modeling concept dynamics for large scale music search

Continuing advances in data storage and communication technologies have led to an explosive growth in digital music collections. To cope with their increasing scale, we need effective Music Information Retrieval (MIR) capabilities like tagging, concept search and clustering. Integral to MIR is a framework for modelling music documents and generating discriminative signatures for them. In this paper, we introduce a multimodal, layered learning framework called DMCM. Distinguished from the existing approaches that encode music as an ensemble of order-less feature vectors, our framework extracts from each music document a variety of acoustic features, and translates them into low-level encodings over the temporal dimension. From them, DMCM elucidates the concept dynamics in the music document, representing them with a novel music signature scheme called Stochastic Music Concept Histogram (SMCH) that captures the probability distribution over all the concepts. Experiment results with two large music collections confirm the advantages of the proposed framework over existing methods on various MIR tasks.
A new standard for food safety and quality

ImpactVision is a machine learning company, applying advanced imaging technology to food supply chains in order to improve food quality, generate consistent products and reduce waste. Our software provides insights about the quality of foods and is aimed at food processors, manufacturers, distributors and retailers. For example, our system is able to determine the freshness of fish, the ripeness of avocados or the presence of foreign objects rapidly, non-invasively and at production grade speeds.

Hyperspectral imaging technology captures information our eyes cannot, in other parts of the electromagnetic spectrum. Our goal is to provide objective, real-time food quality data to the 30,000+ food processing facilities across the USA and improve efficiency of the global food supply chain. Currently, a third of all food produced is wasted. To illustrate the environmental impact at scale, managing food waste sustainably could reduce greenhouse gas emissions by over 500 million tonnes - the equivalent of taking all the cars off the road in the European Union. By digitizing food quality control, we improve yields and prevent waste, whilst increasing food companies’ revenues, which is particularly prescient considering the industry has razor thin profit margins.

ImpactVision combines a hyperspectral sensor installed above a conveyor belt with software that analyzes images and provides real time insights about quality.

By pursuing the present feasibility study, the management team aims to improve its understanding of international market conditions and the associated risks that need to be considered as the company develops a deeper business plan for rolling out, and scaling up ImpactVision as a marketable innovative solution. SME Instrument Phase-1 and Phase-2 will be extremely beneficial in helping the company to accelerate development and market penetration of the solution in target segments, boosting the company’s growth to 94 employees and $109M revenues by 2024.
Thematic Trail Trigger

ThreeT seeks to improve the performance of 8 policy instruments to protect and enhance natural and cultural heritage by setting up thematic trails or improving existing ones, making them accessible to all through green modes of transport and readily available information. The ultimate aim is to maximize the eco-tourism potential of heritage sites. Partners share the challenge that sustainable accessibility to those sites is limited by lack of material links open to sustainable transport modes  and of adequate information to ensure their visibility. This adversely affects strategies for a place-based, sustainable development  of regional economies, since the potential of those sites is not being efficiently utilised. 
To address such challenge, partners’ relevant experience will be shared and jointly analyzed. A minimum of 20 documented good practices will be earmarked, tailored to the specific needs of each partner and suitably fed into the Programme Policy Learning Platform. The experience learning will ultimately result in 8 Action Plans drawn.
Main benefits for the participating regions are:
- Public accessibility and forms of sustainable enhancement of cultural and natural heritage improved.
- New practices on green mobility, intermodality and innovative information adopted.
- Effective system for monitoring the Action Plan to assess the actual influence of its actions on regional development strategies.
-Increased competence and skills of partner staff and key-stakeholders.
The project privileges a bottom up approach for Action Plan formulation with key-stakeholders being involved in all project activities.   
Their contribution by implementing the planned actions is expected to act as a strong multiplier lever for benefit sharing and territorial cohesion of local communities. The Stakeholder Groups established in the project will constitute a permanent forum to ensure a durable impact related to the project issue and consequent actions planned/implemented.
A Simple Aesthetic Approach for Correction of Frontal Sinus Fracture

Frontal sinus fracture management remains controversial and involves preserving function whenever possible or obliterating the sinus and duct as required by the fracture pattern. The purpose of this study was to introduce the simple and effective method in the surgical treatment of the anterior wall of frontal sinus fractures.All 11 patients who presented with anterior wall fractures of the frontal sinus between 2009 and 2013 were included in this study. Two 7-mm stab incisions were made on each side of the fracture, a titanium screw with an attached wire was fixed to the fractured fragment, and an elevator was used to apply force in the opposite vector. One titanium screw was also fixed to the firm normal frontal bone, and the reduction was conducted by observing the C-arm until the fractured fragment reached the height of the normal side.No patients showed any recurrent displacement or infection during the follow-up period, nor did any patient complain of or demonstrate forehead paresthesia. The surgical scar was less than 3 cm in all 11 patients, and all of them reported satisfaction with the results.We obtained the results of an open reduction while using a less invasive method in the surgical treatment of the anterior wall of frontal sinus fractures.
A history of the international human rights regime from the arab-islamic world

How universal is the Universal Declaration of Human Rights? The question attracts more debate than one might expect. This research project—UNIVERSALITY—will break new ground in such debates by contributing an innovative Global History of the origins and development of the international Human Rights regime after the Second World War, from the perspective of the (Arabic-speaking) Islamic  world. The Applicant is a junior academic—a graduate of the London School of Economics, Yale University and Harvard University—with unique professional experience as a diplomat beyond Europe, research fluency in the Arabic language, and experience in journalism communicating to non-specialist audiences, all of which this project leverages. The fellowship will be carried out at the Freie Universität Berlin (FUB) under the supervision of Professor Sebastian Conrad, one of the foremost practitioners in the project field of Global History. The project deliverables address one of the most pressing historical and social needs for our contemporary multicultural Europe—namely, how we can contribute political histories of the twentieth century that place the agency, experiences and political thought of the non-Western world at the centre of historical action. Through innovative method and using a range of neglected sources, UNIVERSALITY will support this objective through reconstructing a hitherto hidden story of the birth and contestation over the UDHR that can also serve as an alternate origins story for our modern international world. And by foregrounding Arab and Islamic perspectives in debates over the international Human Rights regime, it will offer both academic and public new ways of thinking about how we can include non-Western epistemologies in understanding modern-day processes of globalization and integration.
Optimisation Remont

Cofinancer les coûts des services de conseil fournis aux entreprises par des contractants externes dans le cadre de l’introduction d’améliorations des processus commerciaux dans les entreprises.
European Society of Clinical Microbiology and Infectious Diseases (ESCMID) guidelines for the treatment of infections caused by multidrug-resistant Gram-negative bacilli (endorsed by European society of intensive care medicine)

<h2>Abstract</h2><h3>Scope</h3> These ESCMID guidelines address the targeted antibiotic treatment of third-generation cephalosporin-resistant <i>Enterobacterales</i> (3GCephRE) and carbapenem-resistant Gram-negative bacteria, focusing on the effectiveness of individual antibiotics and on combination versus monotherapy. <h3>Methods</h3> An expert panel was convened by ESCMID. A systematic review was performed including randomized controlled trials and observational studies, examining different antibiotic treatment regimens for the targeted treatment of infections caused by the 3GCephRE, carbapenem-resistant Enterobacterales, carbapenem-resistant <i>Pseudomonas aeruginosa</i> and carbapenem-resistant <i>Acinetobacter baumannii</i>. Treatments were classified as head-to-head comparisons between individual antibiotics and between monotherapy and combination therapy regimens, including defined monotherapy and combination regimens only. The primary outcome was all-cause mortality, preferably at 30 days and secondary outcomes included clinical failure, microbiological failure, development of resistance, relapse/recurrence, adverse events and length of hospital stay. The last search of all databases was conducted in December 2019, followed by a focused search for relevant studies up until ECCMID 2021. Data were summarized narratively. The certainty of the evidence for each comparison between antibiotics and between monotherapy and combination therapy regimens was classified by the GRADE recommendations. The strength of the recommendations for or against treatments was classified as strong or conditional (weak). <h3>Recommendations</h3> The guideline panel reviewed the evidence per pathogen, preferably per site of infection, critically appraising the existing studies. Many of the comparisons were addressed in small observational studies at high risk of bias only. Notably, there was very little evidence on the effects of the new, recently approved, β-lactam/β-lactamase inhibitors on infections caused by carbapenem-resistant Gram-negative bacteria. Most recommendations are based on very-low- and low-certainty evidence. A high value was placed on antibiotic stewardship considerations in all recommendations, searching for carbapenem-sparing options for 3GCephRE and limiting the recommendations of the new antibiotics for severe infections, as defined by the sepsis-3 criteria. Research needs are addressed.