SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Emerging tyrosine kinase inhibitors for the treatment of renal cancer

Since both cytotoxic and cytokine therapy were not able to improve the prognosis of advanced renal cell carcinoma (RCC), this tumor has been a good model for the development of new biological agents in the past decade. Five VEGF receptor (VEGFR) and two mammalian target of rapamycin (mTOR) inhibitors are currently available for treatment of this disease but several issues need to be resolved such as a better definition of prognosis, the overcome of resistance and the best therapy for less frequent histologies.This review focuses on new tyrosine kinase inhibitors (TKIs) under investigation in these patients. Study design, phase of investigation, result and emerging toxicities were reported for each molecule. Combination trials involving TKIs with other strategies such as immunotherapy were also covered.Despite the development of more potent and more specific VEGFR TKIs, all tumors ultimately develop resistance to therapy and a plateau has been reached in terms of overall survival. Current research effort to develop new agents aims at overcoming both the primary and the acquired resistance to anti-VEGFR TKIs focusing on new molecular pathways. The ultimate goal is not only to improve patient outcome but to achieve durable complete remission. Several pitfalls that have been responsible for failure of other compounds remain, especially the lack of strong predictive biomarkers and the use of inappropriate tumor assessment criteria that may not accurately capture response to these new therapies.
Evaluation of the Clinical Features of Infertile Women With Subclinical Hypothyroidism in Relatively High-Iodine-Intake Area

Background: It is well known that hypothyroidism may cause menstrual abnormalities, infertility, increased risk of miscarriage, obstetric complications, and adverse outcomes in offspring. On the other hand, some studies have reported the efficacy of supplementation of levothyroxine (LT4) for subclinical hypothyroidism (SCH) in infertile women. The aim of this study was to evaluate the clinical features of infertile SCH patients in Japan. Methods: A total of 156 SCH patients were enrolled in this study. They were divided into two groups: 76 patients who showed positivity for anti-thyroglobulin antibody (TgAb) and/or thyroid peroxidase antibody (TPOAb) were categorized into group A, while 80 patients who showed negativity for both TgAb and TPOAb were categorized into group B. Between these two groups, we evaluated the following factors: age, thyroid function before treatment, presence of hyperprolactinemia, necessary dose of LT4 for correction of thyroid function, thyroid function after treatment, history of abortion, history of pregnancy after treatment, and dose of LT4 before delivery in pregnant subjects. Results: All of the above investigated factors showed no significant differences between groups A and B. However, a notable point was that the necessary dose of LT4 for correcting thyroid function did not show a significant difference, regardless of anti-thyroid autoantibody. Conclusion: In Japan, an area of high iodine intake, in infertile women with SCH, the administration of an adequate dose of LT4 is recommended, regardless of the presence of chronic thyroiditis. J Endocrinol Metab. 2015;5(3):211-214 doi: http://dx.doi.org/10.14740/jem285w
APPLICATORS FOR ARTIFICIAL EYELASHES AND KITS FOR APPLYING ARTIFICIAL EYELASHES

The present disclosure relates to an applicator for artificial eyelashes and a kit for applying artificial eyelashes. The applicator includes a first leg, a second leg rotatably coupled to the first leg at a hinge joint, a first body portion connected to the first leg, and a second body portion connected to the second leg. The first body portion includes a first flange positioned opposite the hinge joint, and the second body portion includes a second flange positioned opposite the hinge joint. The first flange matingly receives the second flange when the second leg is rotated toward the first leg.
High-Throughput 4d imaging for nanoscale cellular studies

Fluorescence microscopy is an invaluable tool for exploring the structure and function of biological processes. It provides high specificity and contrast for the observation of cellular components tagged with fluorescent molecules in a minimally invasive fashion, allowing the study of live specimens. Furthermore, the development of super resolution (SR) fluorescence microscopy has unlocked the access to spatial resolutions beyond the diffraction limit of visible light (~250nm), fuelling the discovery of new biological structures and dynamics. 
Nevertheless, achieving resolutions below ~10nm is challenged by multiple trade-offs between spatial and temporal resolutions, depth of observation and photo toxicity, making it difficult or impossible to obtain a molecular resolution. Additionally, axial resolutions are inevitably poorer than lateral ones, unless utilizing a complex multi-objective lens approach.
I recently developed MINFLUX, a localization technique that merges concepts of SR with information theory. It achieves isotropic nanometer resolution in three dimensions with a single objective lens and has unrivaled spatio temporal resolution. 
However, a platform that enables these capabilities in a high-throughput manner for entire cells and tissue has not yet been developed. I aim to fill this technological gap; with my background and experience, I am in a unique position to assure the success of this project and establish these technologies in the scientific community. The performance of fluorescence imaging and tracking will progress orders of magnitude in the years to come, signaling yet another revolution for optical nanoscopy.
Index of middle english prose: digital cotton catalogue project

The Index of Middle English Prose (IMEP) is the most important reference tool for Middle English non-verse texts. It seeks, for the first time, to locate and identify all surviving English prose texts composed between c. 1200 and 1500. In this project I will aim at developing and testing an innovative digital search tool that will greatly facilitate accessing all entries across the different IMEP catalogues and make it possible to search for texts regardless of the wide range of spelling variation. The prototype of the digital search tool will be based on a draft of an IMEP volume for one of the most famous medieval manuscript collections in Britain: the Cotton collection in the British Library. I will, additionally, edit an IMEP volume for print publication.   The proposed research action formulates three main objectives. These seek to improve the functionality of the IMEP website, to expand the site with the addition of the Cotton volume and to lay the foundation for expansion of the IMEP by writing guidelines for the digitisation of further volumes.    Since I am trained in manuscript studies and Middle English as well as in Digital Humanities and compilation of corpora of historical texts, I possess the necessary expertise to undertake the research action. The action includes research trips to the British Library in London as well as a secondment at the Cambridge Digital Humanities (CDH). The host is the University of Oslo where local expertise is available that is highly pertinent to the research action, including the editor-in-chief of the IMEP and an IMEP advisory board member with complementary expertise in both manuscript studies, Middle English, and natural language processing. The research action will both consolidate and expand my profile to qualify me for an assistant/associate professorship.
Tools for Equitable Urban Intensification

Drawing on the neoliberal and equity planning literature as well as Tiesell and Allmendinger's (2005) four categories of planning tools, this paper seeks to recast the instrumentality of planning tools by examining what opportunities exist to foster more transparent and inclusive management of the urban change process, both from theoretical and practical perspectives. Focusing specifically on urban intensification of existing larger cities, the paper introduces the tensions embodied in delivering planning outcomes equitably in a neo-liberal planning context, and the unique role that planning 'tools' can serve in ameliorating these challenges. The paper will serve to position the author contributions in this special issue, which follow on from a Symposium held in Sydney in April 2013, which showcased urban intensification planning tools and strategies. In this introductory article, the authors argue for a need to critically reflect on how planning 'tools' catalyse urban intensification and the challenges associated with striving for socially equitable planning outcomes, in a neo-liberal reality, when relying on these tools.
A SYSTEM COMPRISING DIFFERENTIAL HYDRAULIC CYLINDERS AND A HYDRAULIC MACHINE COMPRISING THE SYSTEM

A system (1) for moving a tool such as a boom, dipper, bucket or hook of a hydraulic machine such as an excavator, crane or forklift and a hydraulic machine such as an excavator, crane or forklift comprising the system, said system comprising a first bidirectional hydraulic variable displacement pump (11), coupled for liquid flow, via a first flow line (25) to a first differential hydraulic cylinder; a first generator (15); a second generator (17) arranged, when said second generator is in a first operational mode, to be driven by said first generator for generating electrical energy, and when said second generator is in a second operational mode, arranged for driving, together with said first generator, said first bidirectional hydraulic variable displacement pump; a third bidirectional hydraulic pump (19), a first bidirectional hydraulic motor and a first tank (23), wherein said third bidirectional hydraulic pump is arranged to be driven by said first bidirectional hydraulic motor for supplying liquid from said tank to said first flow line and/or adding liquid to said tank from said first flow line; a third flow line, wherein said third hydraulic pump is controlled such that a difference of a flow rate of said liquid in said third flow line and a flow rate of said liquid in said first flow line is within a predetermined range, preferably wherein said flow rates are equal.
INTEGRAZIONE E “MESSA IN RETE” DELLE COMPONENTI DEL MONTE SAN GIORGIO

Studio e realizzazione di percorsi tematici transfrontalieri e “messa in rete”. Obiettivo principale del progetto e quello di mettere in rete le componenti del territorio e le diverse strutture museali, architettoniche e culturali del Monte San Giorgio, finalizzandone la conoscenza a realizzazioni di percorsi tematici, di prodotti a supporto informatico e cartaceo nell’ambito anche di iniziative congiunte di studio circa nuove strategie di marketing transfrontaliero e nel contesto degli scenari che si propongono con la candidatura UNESCO della montagna. Il progetto ha previsto: l’individuazione e lo studio di elementi rilevanti a livello territoriale-naturale, storico, architettonico e culturale, l’impegno dei partecipanti a garantire l’integrazione dei percorsi sul versante svizzero e italiano, la scelta di un percorso tematico transfrontaliero da realizzare, la realizzazione di un prospetto generale sulle peculiarita del Monte San Giorgio e la messa in “rete” di informazioni sull’offerta turistico-didattica e culturale-scientifica del Monte San Giorgio. Inoltre, il progetto prevede per la parte italiana, in conformita ai mezzi finanziari richiesti, la progettazione e la realizzazione di una infrastruttura coerente con gli obiettivi di questa proposta e consistente nella sistemazione di un percorso fra Porto Ceresio e Ca’ del Monte Casolo, finalizzato anche a un collegamento pedonale transfrontaliero con la localita di Serpiano (Svizzera). Coerentemente con le azioni gia svolte a mezzo di INTERREG I e II, si propone quindi di rivalutare un importante percorso storico, che oggi riveste funzione turistica e di rivivificare un bosco misto castagno e faggio a mezzo anche della creazione di punti di sosta panoramici.
La conformidad en España

Sumario -La conformidad del acusado se está convirtiendo a nivel mundial en la forma más común de finalización del proceso penal.Sin embargo, la literatura comparada hace tiempo que viene documentando todos los problemas que plantea esta institución; particularmente, el excesivo poder que confiere al Ministerio Fiscal, las desigualdades en su aplicación e incluso la posibilidad del castigo del inocente.En nuestro país, a pesar de que la conformidad es también la forma usual de finalización del proceso penal, no existen investigaciones empíricas que analicen su aplicación práctica y los problemas que ésta comporta.El presente trabajo tiene por finalidad suplir este vacío presentando por primera vez datos empíricos sobre su aplicación en los juzgados penales y las consecuencias que comporta a nivel de la penalidad.Nuestros resultados muestran que ciertas características de la persona acusada están asociadas con la conformidad (en particular, los extranjeros presentan una tasa significativamente menor de conformidades), y que la negativa del acusado a conformarse tiene un impacto relevante en la ejecución de la pena de prisión (en concreto, aquellos que se conforman tienen más posibilidades de ver su pena de prisión suspendida o sustituida).
Small-scale modelling of cementation by descending silica-bearing fluids: Explanation of the origin of arenitic caves in South American tepuis

Abstract Geoscientific research was performed on South American table mountains (tepuis) and in their sandstone cave systems. To explain speleogenesis in these poorly soluble rocks, two theories were introduced: a) arenization theory implying selective weathering of quartz along grain boundaries and releasing of sand grains, b) selective lithification theory implying cementation by descending silica-bearing fluid flow. The latter theory presumes that the descending fluid flow becomes unstable on the interface between two layers with different porosity and splits to separate flow channels (so-called “finger flow”). The arenites outside these channels remain uncemented. To verify the latter theory, small-scale modelling was performed, using layered sands and sodium-silicate solution. Fine to medium sand was used (0.08–0.5 mm), along with a coarse sand fraction (0.5–1.5 mm). The sands were layered and compacted in a transparent plastic boxes. Three liters of sodium-silicate solution (so-called water glass) were left to drip for several hours to the top of the sediment. The fine-grained layers were perfectly laterally impregnated, whereas the descending fluid flows split to “fingers” in the coarse-grained layers due their higher hydraulic conductivity. This small-scale laboratory simulation mimics the real diagenesis by descending silica-bearing fluids and matches the real phenomena observed on the tepuis. The resulting cemented constructions closely mimic many geomorphological features observed on tepuis and inside their caves, e.g. “finger-flow” pillars, overhangs, imperfectly formed (aborted) pillars in forms of hummocks hanging from ceilings, locally also thicker central pillars that originated by merging of smaller fluid-flow channels. The modelling showed that selective lithification theory can explain most of the geomorphological aspects related to the speleogenesis in tepuis.
The Third Industrial Revolution

Publisher Summary The book of Woodrow W. Clark and Grant Cooke, MJ, explores that the countries, states, regions, and communities of all kinds must eliminate their dependence on fossil fuels, stop their renewed focus on nuclear power. It should reverse the pace of environmental degradation. To do so, communities must embrace the reality of smart grids, emerging storage technologies, and renewable energy generation. The book also depicts that the nations must take these actions now to create and implement the Third Industrial Revolution (3IR) for themselves. They need to reduce the energy dependency on the Middle East, a geopolitical region whose instability constantly threatens national security and keeps nations from focusing on crucial domestic issues such as health care, financial reform, and innovation, as well as the planetary environmental crisis. According to the writer—since the Great Depression of the 1930s—the world is battling the most severe economic turndown on an economic front. Nationwide, states are reeling with the loss of tax and real estate development revenue.
FPGA implementation of a real-time image tracking system

This article focuses on realizing an object tracking and image capture system on a FPGA. The system processes each picture with size of 640×480 pixels which is coming from input image data captured by an external CCD camera. Firstly, the RGB format of input image data is transformed to HSV format through color space transformation. Secondly, the value (also called intensity) of HSV format image is adjusted by the histogram equalization process to enhance the image brightness. Thirdly, skin color detection and binarization process is employed on the resulting HSV image. Fourthly, the system dilates the binary image to make up the flaws on the image. Finally, the image is checked to determine if there is any possible skin color area which its horizontal width is larger than a threshold. If so, then the area is qualified to be a suspected object and the surveillance system controls a 2-dimentional rotation machinery to track the object. Meanwhile, the captured object image is synchronously displayed on a VGA screen and saved into a SD card. Designed under hardware and software co-design methodology, the resulting system has been experimentally proved that it satisfies the goal of real-time detecting and tracking of suspected objects.
Clinical Study on Treating Lulvar White Lesion by TCM Combined Therapies

Objective To search for TCM Internal and external application to therapy for Chronic vulva dystrophy.Methods According to the therapeutic program,we divided the 150 Patients into 3 treatments.Treatment Ⅰ:50 cases applied by internal and external TCM and 2% testosterone propionate ointment.Treatment Ⅱ:50 case applied external TCM and 2% testosterone propionate ointment treatment Ⅲ:50 cases applied by 2% testosterone propionate ointment only.Results Treatment Ⅰ:29 cases were cured,13 markedly effective,8 effective and 0 ineffective,the total effective rate(100%);Treatment Ⅱ:10 cured,7 markedly effective,22 effective,11 ineffective,the total effective rate(78%);Treatment Ⅲ:1 cured,9 markedly effective,12 effective,28 ineffective,the total effective rate(44%).Conclusion 1.Internal TCM recipes as shengjing and ganxue-tonic,heat-clearing and dampness-eliminating,Qixue-tonics and bettering skin.2.External washing TCM and plaster to control clitoris and pudendumadhesion.3.By the reason of the period of inflamed cells slough,we schedule the therapy into treating and reserving intervals,so the efficacy is steady.
The role of cattle at prehistoric lake-dwelling sites in switzerland: an investigation of husbandry practices and the spread of cultural influence.

The development of farming in the Neolithic fundamentally changed human life. Livestock animals and farming innovations are thought to have spread across Europe during the Neolithic period via two distinct dispersal routes: 1. along the Danube corridor and through central Europe and 2. along the Mediterranean coast. This resulted in two distinctive cultural areas linked with particular modes of animal husbandry; a central European area with cultures based on cattle herding, and a Mediterranean area with cultures based on caprine husbandry. These husbandry patterns became embedded in these regions and remained the focus of agricultural practices into the Bronze Age and beyond. Switzerland is located between these two geographical and cultural regions and the Neolithic and Bronze Age cultures here represent a rare meeting and interaction point between them, yet very little work has explored the nature of this. Switzerland also has many large assemblages of perfectly preserved faunal remains from prehistoric lake dwelling sites where precise dating of different settlement phases can be achieved, representing a rare opportunity for the study of human-animal interactions with incredible temporal precision.
The LAKEBOS project will use cattle, the most common domestic species at Swiss prehistoric sites, and a vital part of the new Neolithic farming ‘package’, as a proxy for investigating the way in which prehistoric agricultural practices from central European and Mediterranean cultures passed through this region and interacted with each other. It will use archaeozoological methods to investigate body size and shape change and demographic fluctuations on both a spatial and temporal scale. It will also use ancient DNA to investigate the potential for the introduction of new cattle groups into the region. The spread of agricultural innovations across Europe is the focus of some of the most important debates in archaeology, and this project will provide a vital contribution.
VILLA RIVIERA S.R.L.

VILLA RIVIERA ES UNA VILLA DEL '900, COMPLETAMENTE RENOVADA DURANTE 2018 PARA DAR VIDA A UNA BOUTIQUE RELAIS QUE QUIERE COMBINAR LOS MÁS ALTOS ESTÁNDARES INTERNACIONALES CON EL AMBIENTE DE LA RIVIERA LIGURIA Y LA TÍPICA HOSPITALIDAD ITALIANA. SU POSICIÓN PRIVILEGIADA EN EL CERRO DE SANTA GIULIA LE PERMITE DISFRUTAR DE UNA VISTA ÚNICA DEL GOLFO DE TIGULLIO Y ADMIRAR SU BELLEZA DESDE PORTOFINO HASTA SESTRI LEVANTE. UN CONCEPTO «BOUTIQUE RELAIS», CON SEIS SUITES DE LUJO, Y UN PEQUEÑO RESTAURANTE GOURMET RESERVADO PARA LOS HUÉSPEDES. VILLA RIVIERA SE INAUGURÓ EN 2018 Y HASTA AHORA HA ATRAÍDO A MÁS DE 2000 INVITADOS PROCEDENTES DEL 70 % DEL EXTRANJERO Y DEL 30 % DE ITALIA. EL PROYECTO ES AMBICIOSO PORQUE EL OBJETIVO ES RECREAR EL AMBIENTE Y LOS ESTÁNDARES DE SERVICIOS QUE LOS CLIENTES PUEDEN ENCONTRAR EN LOS CIRCUITOS DE BELMOND PERO TAMBIÉN EN LOS FAMOSOS HOTELES EN LAS COLINAS DE LA COSTA DE AMALFI. LA PROPIEDAD ESTÁ ACTUALMENTE ABIERTA DE MARZO A NOVIEMBRE Y EN 2020 ‘CUANDO SEA POSIBLE’
“What any Parent Knows” But the Supreme Court Misunderstands

In Miller v. Alabama, the Supreme Court appealed to neuroscience studies concerning the diminished capacities of adolescents to justify leniency in the sentencing of juvenile offenders. Reflecting on the recent proliferation of juvenile proportionality cases, the Court noted “[o]ur decisions rested not only on common sense—on what ‘any parent knows’—but on science and social science as well.” This Article casts a skeptical eye on the legal import of these scientific insights into the adolescent brain for normative evaluations of criminal culpability. Although the studies cited offer little probative value beyond the common sense wisdom about children that “any parent knows,” the Court’s efforts to employ psychiatric data to objectify mitigating criteria have distracted the Justices from analyzing the precise legal relationship between diminished capacity and diminished culpability, while intractably confusing the Eighth Amendment doctrine of proportionality. After analyzing the history of both proportionality review and the diminished capacity defense, this Article cautions that judges should not automatically equate factual findings of neurobiological abnormalities—that merely evidence diminished capacity—with a moral-legal conclusion of lessened culpability. Given the wide applicability of this defense, such reductionist interpretations contravene the principles of moral responsibility, which seek to differentiate culpability among individual offenders. As an alternative means of reconciling the burgeoning role of neuroscience with the established tenets of the criminal doctrine, this Article proposes a novel framework for assessing the mitigating effect of brain science that judges could equally apply to all classes of offenders, including juveniles.