SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
[Bevacizumab combined with chemotherapy for advanced non-small cell lung cancer: a meta-analysis].

Bevacizumab is a recombinant, humanised, monoclonal antibody against the vascular endothelial growth factor receptor (VEGFR), the aim of this meta-analysis is to evaluate the clinical efficacy and safety of bevacizumab combined with chemotherapy for non-small cell lung cancer (NSCLC).The CBM, CNKI, VIP, WanFang, The Cochrane Library, PubMed, Ovid, EMBASE and SCI etc were retrieved by computer, the randomized controlled trials (randomized control trial, RCT) of bevacizumab combined with chemotherapy in the treatment of NSCLC were collected by us. The outcomes included overall survival (OS), progression-free survival (PFS), response rate (RR), toxicities and treatment related mortality. Relative risk (RR) and hazard ratios (HR) were used for the meta-analysis and were expressed with 95% confidence intervals (95%CI), and the software Stata 12.0 was used for meta-analyses.Six trials and 2,338 advanced NSCLC patients were included. Meta analysis indicated that compared with chemotherapy alone, the bevacizumab (7.5 mg/kg or 15 mg/kg) combination with chemotherapy could increase overall survival rate (RR=1.68, P<0.01, 95%CI: 1.31-2.15; RR= 1.79, P<0.01, 95%CI: 1.53-2.08), and could decrease the progression of the disease risk (HR=0.75, P<0.01, 95%CI: 0.61-0.89; HR=0.69, P<0.01, 95%CI: 0.62-0.77) and the risk of disease death (HR=0.94, P<0.01, 95%CI: 0.77-1.10; HR=0.87, P<0.01, 95%CI: 0.78-0.97). The high dose of bevacizumab (15 mg/kg) combination with chemotherapy could increase the treatment related mortality (RR=1.88, P=0.010, 95%CI: 1.16-3.05) and the rates of other toxic reaction.Whether first-line or second-line treatment, the addition of bevacizumab to chemotherapy in patients with advanced NSCLC prolongs RR, OS and PFS.
Bioaccessibility of selenium after human ingestion in relation to its chemical species and compartmentalization in maize

Selenium is a micronutrient needed by all living organisms including humans, but often present in low concentration in food with possible deficiency. From another side, at higher concentrations in soils as observed in seleniferous regions of the world, and in function of its chemical species, Se can also induce (eco)toxicity. Root Se uptake was therefore studied in function of its initial form for maize (Zea mays L.), a plant widely cultivated for human and animal food over the world. Se phytotoxicity and compartmentalization were studied in different aerial plant tissues. For the first time, Se oral human bioaccessibility after ingestion was assessed for the main Se species (Se(IV) and Se(VI)) with the BARGE ex vivo test in maize seeds (consumed by humans), and in stems and leaves consumed by animals. Corn seedlings were cultivated in hydroponic conditions supplemented with 1 mg L(-1) of selenium (Se(IV), Se(VI), Control) for 4 months. Biomass, Se concentration, and bioaccessibility were measured on harvested plants. A reduction in plant biomass was observed under Se treatments compared to control, suggesting its phytotoxicity. This plant biomass reduction was higher for selenite species than selenate, and seed was the main affected compartment compared to control. Selenium compartmentalization study showed that for selenate species, a preferential accumulation was observed in leaves, whereas selenite translocation was very limited toward maize aerial parts, except in the seeds where selenite concentrations are generally high. Selenium oral bioaccessibility after ingestion fluctuated from 49 to 89 % according to the considered plant tissue and Se species. Whatever the tissue, selenate appeared as the most human bioaccessible form. A potential Se toxicity was highlighted for people living in seleniferous regions, this risk being enhanced by the high Se bioaccessibility.
Methionine Enkephalin (MENK) Inhibits tumor growth through regulating CD4+Foxp3+ Regulatory T cells (Tregs) in mice

Methionine enkephalin (MENK), an endogenous neuropeptide, plays an crucial role in both neuroendocrine and immune systems. CD4+Foxp3+ regulatory T cells (Tregs) are identified as a major subpopulation of T lymphocytes in suppressing immune system to keep balanced immunity. The aim of this research work was to elucidate the mechanisms via which MENK interacts with Tregs in cancer situation. The influence of MENK on transforming growth factor-β (TGF-β) mediated conversion from naïve CD4+CD25- T cells to CD4+CD25+ Tregs was determined and the data from flow cytometry (FCM) analysis indicated that MENK effectively inhibited the expression of Foxp3 during the process of TGF-βinduction. Furthermore, this inhibiting process was accompanied by diminishing phosphorylation and nuclear translocation of Smad2/3, confirmed by western blot (WB) analysis and immunofluorescence (IF) at molecular level. We established sarcoma mice model with S180 to investigate whether MENK could modulate Tregs in tumor circumstance. Our findings showed that MENK delayed the development of tumor in S180 tumor bearing mice and down-regulated level of Tregs. Together, these novel findings reached a conclusion that MENK could inhibit Tregs activity directly and retard tumor development through down-regulating Tregs in mice. This work advances the deepening understanding of the influence of MENK on Tregs in cancer situation, and relation of MENK with immune system, supporting the implication of MENK as a new strategy for cancer immunotherapy.
Drivers and projections of global fire activity and intensity under future climate and societal changes.

Vegetation fire patterns depend on environmental drivers that are expected to change in the future, including climate and the expansion of agriculture and associated fire practices into natural ecosystems. In return, fires have a major influence on vegetation distribution, the carbon cycle and climate. It is important to anticipate the result of these interactions on future ecosystem dynamics and carbon emissions, and to integrate these outlook when designing societal strategies for climate mitigation. Such an integrative approach is especially relevant to terrestrial policies (e.g. REDD), which could drastically modify global landuse patterns and thus the anthropogenic footprint on fire regimes. In a first stage of the proposed research, we will improve our understanding of fire drivers through innovative observation data assimilation methods. We will focus on depicting the influence of climate and fuel on fire intensity, and of human activities on fire incidence, which are well-recognized research priorities. In a second stage, we will deploy this knowledge in multi-disciplinary settings to provide the first assessment of future fire regimes under economic, agricultural and climate scenarios. We will use existing and new scenarios from integrated assessment models with particular attention to design experiments of maximum relevance to the environmental policy commitments of the European Union.
The effect of transportation suit induced heat stress on helicopter underwater escape preparation and task performance

Although essential in an emergency such as a helicopter ditching, mandatory survival suits worn by civilian personnel may lead to heat strain during a normal flight. To explore the possibility that wearing a helicopter transportation suit impairs emergency performance, 11 individuals completed underwater escape procedures immediately following a pre-recorded emergency announcement (randomly played between 50 and 90 min) in two ambient temperature conditions (Thermoneutral = 21 °C and Hot = 34 °C). Mean skin and rectal temperatures were recorded throughout the trials, while situation awareness and thermal sensation/comfort were recorded on completion of trials. Results indicate that although mean skin and rectal temperatures were significantly higher at the end of both trials, escape procedures were not impaired. It can therefore be concluded that although conditions inside an offshore transport helicopter are perceived as being hot and uncomfortable, no deficits in escape performance should be expected in the first 90 min of flight.
DEM registration using watershed algorithm and chain coding

DEM (Digital Elevation Model) is the model that gives elevation of each point of the earth surface in discrete form in a 3-D space. Image registration, implies registration of multi-temporal, multi-modal, multi-resolution, images of the same area. Registration of DEMs is now a days gaining a lot of popularity among the research community. DEM registration, in this case, is the registration of multi-temporal DEMs. Popular techniques for feature extraction and matching include wavelet approach, robust SIFT, or are based super-points. This paper presents the DEM registration scheme based on watershed transformation, followed by two post-processing steps of clustering and morphological operations which is applied on both the DEMs -- candidate, as well as, reference DEM. Chain coding based matching is concluding step of the complete process. The system is semi-automatic i. e. expert input is considered before the final registration. Experimental results give good outcomes as shown from the error matrix analysis of RMSE, and PSNR. The system may be extended by using fuzzy classification and context-sensitive learning.
Analysis of Shielding Effectiveness of Metallic Rectangular Enclosures Using Efficient Integral Equations

The paper proposes an efficient modeling technique for electromagnetic analysis of a rectangular metallic enclosure with multiple apertures, using the surface equivalent principle and frequency-domain integral equations. The surface equivalence principle is used to replace the apertures by a prefect electrically conducting surfaces while introducing appropriate magnetic current densities on both sides of it with opposite sign. As a result, the problem is reduced to two independent regions. The first region is outside the enclosure (exterior problem) where the free space Green’s function with the aid of image theory can be used to obtain the total fields in it. The second region is the interior of the enclosure (interior problem) that a closed-form expression for its dyadic Green’s function is available. Finally the governing frequency-domain magnetic field integral equation for the structure is derived by enforcing the continuity of the tangential magnetic field at the apertures. To solve the resulting integral equations, method of moments is used. The validity of the proposed method is confirmed by comparing the simulation results of several case studies with those obtained using the commercial MWS-CST finite integration code.
Myeloid  cells: investigating their role for immunotherapy in cancer

With more than 3.7 million new cases and 1.9 million deaths each year, cancer represents the second most important cause of death and morbidity in Europe with the estimated direct health cost increasing from €79 to €86 billion during 2005-2014. The emerging field of immune-checkpoint therapy (ICT) has demonstrated unprecedented responses in patients with several types of metastatic tumors that were previously resistant to available treatment options. However only ~13% of patients respond to the immunotherapy. I believe the primary reason for this is that most therapies are T cell directed and to achieve durable responses one must also engage the innate arm of the immune system. Myeloid cells constitute a major proportion of tumor infiltrating cells in human cancers and are essential for the induction of antigen specific T cell responses-cells which mediate anti-tumor immunity.  Tim-3 is a check-point molecule that is not only expressed on T cells but also constitutively expressed on Dendritic cells, namely DC1, which are particularly adept at initiating protective anti-tumour immunity. A number of studies have highlighted the crucial role of DCs including analyses of The Cancer Genome Atlas showing that patient survival for many cancers correlates positively with the gene expression signature for DCs. Given the current activity in developing Tim-3 blocking agents for clinical translation, it is imperative that we have a full understanding of how modulation of Tim-3 affects the innate arm of the immune system.   The aim of this proposal is to determine the cell-intrinsic and non cell-intrinsic effects of Tim-3 modulation in cancer.  Furthermore we will analyze the cellular and transcriptional changes associated with tumour infiltrating DC after ICT with anti-Tim3. This proposal is highly interdisciplinary implementing single-cell 'omics' strategies and systems immunology approaches to further unravel the players and rules governing immune responses during malignancy.
Digiteal: european payment and e-invoicing platform

Digiteal is a payment and e-invoices management platform that works in synergy with the Digital Single Market policy. We will support standardization and enable payment in and between all countries of the SEPA zone. Our payment platform gives value to companies within the European Union and to customers by cutting those interoperability transaction costs within the EU and giving EU citizens a complete control of their SEPA mandates. 
Digiteal aims to reduce the huge dependencies on US online payment services. On the other hand, Digiteal is unique offering a SEPA domiciliation management platform for end-users. Users will be able to manage the bills of all the companies using a unique domiciliation platform.
Our innovation is to apply the same principle to e-Invoicing.
Our clients are B2C European companies that issue high volume of invoices in paper. We offer an intuitive platform to manage their invoices and reducing the operating costs. Our end users will be able to manage and pay their mandates and invoices for free.
During the feasibility assessment in phase I we will study how to develop our SDD payment functionality, study the integrations with European document service providers and detail an International commercialization and Business plan. Also, a Freedom to operate analysis will be performed.
Digiteal is a new way of managing invoices and making the SDD payment using disruptive technologies breaking the cross-border limitations within the European countries and our solution will reduce the actual European huge USA dependencies on online payment services. Digiteal will improve the competitiveness of the European companies. We will seize the opportunity brought by the need of modernization of the European unified marketplace, identified by the top priority need of creating a Digital Single Market Strategy within the European Agenda.
Delivering Efficient Sustainable Tourism with low-carbon transport Innovations: Sustainable Mobility, Accessibility and Responsible Travel

Integration of regional/local policies for Sustainable Mobility, Accessibility & low-carbon Responsible Travel, with policies for efficient sustainable tourism towards a low-carbon economy, requires particular attention in the EU. This is a common challenge that public regional/local and transport authorities increasingly face, particularly at busy destinations with high tourism travel flows (inc. in South Europe, coastal, maritime & insular, mass tourism destinations). Immediate action is needed through interregional cooperation to capitalise best practices, improve policy instruments & prepare action plans with implementation monitoring & evaluation.

The DESTI-SMART project, addresses the above towards 'Smart Destinations', for sustainable & responsible tourism development in Europe, with low-carbon, multimodal sustainable mobility & accessibility.

The overall objective is to improve the transport and tourism policies of EU destinations, by integrating strategies for sustainable mobility, accessibility and responsible travel with efficient & sustainable tourism development, for transition to a low-carbon economy, through efficiency, resilience, multimodality, novel low-carbon transport systems, cycling & walking, with implementation innovations, policy learning and capacity building.

The following pressing issues are addressed:
- Investments in low-carbon transport systems for mode shift to sustainable tourism mobility, incl. Electro-Mobility.
- Intermodality facilities for visitors, including ICT, Mobile Aps & MaaS.
- Accessible tourism for all.
- Cycling & Walking facilities & promotion for visitors.

Main outputs:
- policy learning & capacity building for public authorities & their stakeholders.
- improved policy instruments & action plans in 9 destinations, with close involvement of stakeholders.
- advances in EU2020 objectives.
- communication & dissemination learning materials.
- network of public authorities towards low-carbon S.M.A.R.T. destinations in Europe.
Desarrollo de un diseño innovador y prototipo de la física de la bicicleta de acrobacia junto con un conjunto de elementos principales y laterales de la funcionalidad del juego replicando fielmente el modelo real

Number_reference_aid_programa: SA.41471(2015/X) Objetivo de la ayuda pública: Artículo 25 del Reglamento (CE) n.º 651/2014, de 17 de junio de 2014, por el que se declaran determinadas categorías de ayudas compatibles con el mercado interior en la aplicación de los artículos 107 y 108 del Tratado Eso es todo. EU L 187/1 de 26.6.2014). &bdquo; Desarrollar un diseño innovador y prototipo de la física de la moto stunt &hellip; (en lo sucesivo: Design), es desarrollar un modelo informático interactivo de la motocicleta en un entorno de videojuegos, de tal manera que el jugador sea capaz de controlarlo con la ayuda de un controlador y utilizar las características de movimiento del tipo «stunt ride &rdquo;» para superar obstáculos y etapas posteriores del juego. Esto se logrará tanto a través de la investigación industrial como del desarrollo. La singularidad del proyecto consiste en la representación realista de un tipo específico de motocicleta y el deporte extremo asociado. La palabra truco es clave aquí, porque la naturaleza del comportamiento de un vehículo de este tipo requiere el desarrollo de una tecnología específica. La técnica de conducción de acrobacias es muy difícil de describir digitalmente y de diseñar en un modelo físico debido a las numerosas características que distinguen este tipo de uso de la mecánica de motocicletas. La conducción acrobacia se caracteriza por el control total del vehículo y la coordinación del comportamiento entre la motocicleta y el conductor, que se requiere para realizar acrobacias tales como: conducción en la rueda trasera o delantera, deriva, etc. La simulación precisa mapeando el modelo real presentará convincentemente en el juego el comportamiento de la motocicleta y el conductor. El jugador tendrá una sensación de control de una motocicleta real y también será capaz de interactuar de manera convincente con obstáculos dinámicos y estáticos en el mundo del juego. En relación con los modelos en el mercado, surgirán nuevas posibilidades gracias a los supuestos clave planificados, a saber, la tridimensionalidad del modelo físico (mayor libertad de movimiento), la tracción (distancia), el impacto del mod
Variable Vector Countermeasure Suit (V2Suit) for Space Exploration

The “Variable Vector Countermeasure Suit (V2Suit) for Space Exploration” is an integrated countermeasure platform to mitigate the spaceflight-induced physiologic adaptation and de-conditioning that manifests during long-duration spaceflight and gravitational transitions. The V2Suit integrates flywheel gyroscopes and inertial measurement units within a wearable module that can be placed on the body segments, and when commanded in a coordinated manner provides a “viscous resistance” during movements. The system architecture, human-system integration, and three six degree-of-freedom simulations are presented which describe the magnitude and direction of the gyroscopic torque and resulting force within the module during representative arm movements. The results demonstrate of the ability of the V2Suit module design to generate a reaction force along a specified direction and reject perturbations due to body kinematics - collectively illustrating the feasibility of the concept.
Tle easy identification of optimal translators in a global digital marketplace

The Language Service Providers (LSP) in the translation industry currently relies heavily on freelance translators, but despite a high global demand for text translation services, it appears increasingly difficult to find adequately qualified translators for the job. Additionally, LSPs are subject to an increasing pressure to deliver higher quality translations while cutting down on costs and time. Despite improvements on automated translations via software, human translators are necessary to provide quality work. In an attempt to bridge that gap, EasyTranslate has developed VAL, a self-learning platform which will analyse and classify the text by keywords and match the task to the most qualified translator for that particular job. The platform will then analyse the translated text to improve its understanding of the translation made and provide a better match in the future. VAL links the customer seamlessly to the translator and makes an instantaneous best value offer thanks to a dynamic pricing algorithm. The customer therefore enjoys a faster process of higher quality with a better transparency on the VAL platform. EasyTranslate already evolves in the large global translation market, including most of its activity in the European Union, with many large customers including the Danish state and private corporations. The EU has shown a steady interest in efficient translation services and will continue on supporting the demand in the years to come with constant growth. As a cloud-based SAAS product, VAL will be accessible online to any individual, organisation or corporation that requires translation services. It will initially focus on translations between English and French, German or Chinese, and will be extended to its large customer database overtime. 

The phase 1 project validates the feasibility of VAL as a project for the market. The concept will be confirmed commercially, financially and technically, to ensure due diligence of the business plan viability.
Toward the laboratory identification of [O,N,S,S] isomers: Implications for biological NO chemistry

Benchmark ab initio calculations are performed to investigate the stable isomers of [O,N,S,S]. These computations are carried out using coupled cluster (RCCSD(T)) and explicitly correlated coupled cluster methods (RCCSD(T)-F12). In addition to the already known cis isomer of SSNO, nine other stable forms are predicted. The most stable isomer is cis-OSNS. Nine structures are chain bent-bent with relatively large dipole moments which make them detectable, as cis-SSNO, by infrared, far-infrared, and microwave spectroscopies. We found also a C2v isomer (NS2O). Since these species are strongly suggested to play an important role as intermediates during the bioactive reaction products of the NO/H2S interaction, the rotational and vibrational spectroscopic parameters are presented to help aid the in vivo identification and assignment of these spectra. Results from this work show that [O,N,S,S] may play key roles during nitric oxide transport and deliver in biological media, as well as, provide an explanation for the weak characteristic of disulfide bridges within proteins.