SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Pathological features and prognosis of different molecular subtypes of breast cancer

To examine the pathological features and prognosis of different molecular subtypes of breast cancer, the clinical data of 892 breast cancer patients were retrospectively analyzed and divided into four subtypes according to hormone receptor expression in breast cancer tissue: Her-2 overexpression, luminal A, luminal B and basal-like subtypes. The pathological data and prognosis of these subtypes were compared. Of the 892 breast cancer patients, there were 46 cases (5.2%) with Her-2 overexpression-type, 698 cases (78.3%) with luminal A-type, 38 cases (4.3%) with luminal B-type and 110 patients (12.2%) with basal-like-type. Immunohistochemistry was used to identify the progesterone and estrogen receptors in the tumor tissues. The χ2 test was used to verify the measurement data. The Cox proportional hazard regression model was used for the univariate and multivariate analyses. Results showed there was no statistical difference for lymphatic metastasis among the various molecular subtypes of breast cancer (P>0.05). The distant metastatic rate of patients with Her-2-type breast cancer was significantly higher compared to patients with the other three subtypes (P<0.05). The difference in local recurrence among molecular subtypes was not significantly significant (P>0.05). Lymph node metastasis, age and different molecular subtypes were found to have an impact on patient overall survival (OS) and disease-free survival (DFS). Her-2 overexpression-type breast cancer patients had the lowest 9-year DFS and 7-year OS compared to the other subtypes (P<0.05). Thus, Her-2-type was associated with the worst prognosis. In conlusion, the molecular typing of breast cancer has important clinical value in prognosis estimation and is expected to affect breast cancer treatment approaches.
Oxygen Isotopic Exchange Probes of ATP Hydrolysis by RNA Helicases

It is often possible to obtain a detailed understanding of the forward steps in ATP hydrolysis because they are thermodynamically favored and usually occur rapidly. However, it is difficult to obtain the reverse rates for ATP resynthesis because they are thermodynamically disfavored and little of their product, ATP, accumulates. Isotopic exchange reactions provide access to these reverse reactions because isotopic changes accumulate over time due to multiple reversals of hydrolysis, even in the absence of net resynthesis of significant amounts of ATP. Knowledge of both the forward and reverse rates allows calculation of the free energy changes at each step and how it changes when coupled to an energy-requiring conformational step such as unwinding of an RNA helix. This chapter describes the principal types of oxygen isotopic exchange reactions that are applicable to ATPases, in general, and helicases, in particular, their application and their interpretation.
NONWOVEN FABRICS

This invention relates to nonwoven fabrics with advantageous characteristics and the method to produce these fabrics. Advantageously, the fabrics of the subject invention have increased thickness (loft) compared to conventional nonwoven fabrics and have high air permeability and open space while maintaining softness and strength at the same basis weight.
LE TOMBE FEMMINILI NELLA NECROPOLI DI VIALE SANTA PANAGIA A SIRACUSA (VI-IV SEC. A.C.)

La presente contribución analiza una serie de tumbas femeninas recientemente excavadas en Siracusa, asociadas a contextos funerarios típicos del paso de la I a la II Edad del Hierro en la isla de Sicilia en ámbito griego, y que representan una revisión del concepto de identidad y de género en el ámbito de la arqueología de la muerte en la Protohistoria.
NEC Standards of Safety

Publisher Summary Many people think of NEC requirements as a performance standard, when they actually provide the bare minimum for safe installations. The guidelines are not meant to provide the most convenient or efficient installations and don't even guarantee good service or allow for future expansion. They are designed to provide a standard for safety that protects against electrical shock and thermal effects, as well as dangerous overcurrents, fault currents, and overvoltage. The insulation on a conductor imprisons the dangerous electrical current running through it and guards against shock, fire, and arc incidents. For this reason, one must size conductors properly so that excessive loads do no overheat the conductors and damage the protective insulation. Article 310 of the NEC deals with the minimum size requirements for conductors based on their voltage rating. NEC Article 310.15 addresses ampacity, which needs to be cross-referenced to NEC Table 310.5, because Article 310.15 doesn't take voltage drop into consideration.
BRAKING SYSTEM FOR CLOSING A BUCKET COVER

The invention relates to a braking system for closing a cover of a shovel bucket, comprising at least one hydraulic braking sub-system, mounted on a shovel bucket where the cover pivots, wherein each sub-system comprises a braking connecting bar in the upper part, a chassis in the lower part which is supported and joined to the wall of the bucket, an assembly formed by an external tank having oil inside and a double-acting hydraulic cylinder joined at one end to the chassis, with the other end being joined to an arm comprising a cam system which regulates the movement of the respective sub-system in order to control the closing of the cover, wherein the chassis also comprises at least one flow regulator valve and at least one anti-return valve.
COSMETIC DISPENSER WITH CAM LOCKING FEATURE

A cosmetic preparation dispenser is provided that has a helical cam track with a horizontal step at its lower end and a longitudinal innerbody track that terminates adjacent the horizontal step. A cam follower lug of an elevator cup will track into and be trapped by and between the horizontal step and the lower end of the longitudinal track. This locks the innerbody to the cam sleeve to prevent longitudinal sliding of the innerbody relative to the cam sleeve when, e.g., a lipstick cover is removed in an assembled cosmetic container, which cover removal might leave an undesirable gap between the decorative shells surrounding the innerbody and cam sleeve.
fMRI correlates of object-based attentional facilitation vs. suppression of irrelevant stimuli, dependent on global grouping and endogenous cueing

Theories of object-based attention often make two assumptions: that attentional resources are facilitatory, and that they spread automatically within grouped objects. Consistent with this, ignored visual stimuli can be easier to process, or more distracting, when perceptually grouped with an attended target stimulus. But in past studies, the ignored stimuli often shared potentially relevant features or locations with the target. In this fMRI study, we measured the effects of attention and grouping on Blood Oxygenation Level Dependent (BOLD) responses in the human brain to entirely task-irrelevant events.Two checkerboards were displayed each in opposite hemifields, while participants responded to check-size changes in one pre-cued hemifield, which varied between blocks. Grouping (or segmentation) between hemifields was manipulated between blocks, using common (versus distinct) motion cues. Task-irrelevant transient events were introduced by randomly changing the colour of either checkerboard, attended or ignored, at unpredictable intervals. The above assumptions predict heightened BOLD signals for irrelevant events in attended versus ignored hemifields for ungrouped contexts, but less such attentional modulation under grouping, due to automatic spreading of facilitation across hemifields. We found the opposite pattern, in primary visual cortex. For ungrouped stimuli, BOLD signals associated with task-irrelevant changes were lower, not higher, in the attended versus ignored hemifield; furthermore, attentional modulation was not reduced but actually inverted under grouping, with higher signals for events in the attended versus ignored hemifield.
Epidemiological study on Schistosoma mansoni infection in Sanja area, Amhara region, Ethiopia

The epidemiology of schistosomiasis is well documented and its geographic distribution has been mapped and there is an ongoing mapping in Ethiopia. Nevertheless, new transmission foci have been discovered in different parts of the country. The objective of this study was to assess the establishment of transmission and determine the prevalence of Schistosoma mansoni infection in school children from Sanja Town, northwest Ethiopia.A cross-sectional parasitological survey involving 384 school children in two primary schools of Sanja Town was conducted between February and April 2013. Stool specimens were collected and microscopically examined using Kato-Katz and Sodium acetate-acetic acid-formalin (SAF) concentration methods. Malacological survey was also carried out to identify snail intermediate hosts and larval infection rate in the snail. The snails collected were checked for trematode infection by shedding. Observation was also made on water contact habits of the study population.The prevalence of Schistosoma mansoni infection using Kato-Katz method was high among male (79.5%) children in Sanja Primary school while it was high among female (75%) children in Ewket Amba Primary school. The prevalence of Schistosoma mansoni infection among Sanja Primary school children in the age groups 5-9 and 10-14 years were 84.6% and 75.2%, respectively while in Ewket Amba Primary school, the prevalence was 66% and 77.9% in the age groups 5-9 and 10-14 years respectively. The prevalence of schistosome infection in Biomphalaria pfeifferi was 16.9% and 0.027% during February and April, respectively. S. mansoni infection was successfully established in laboratory mice and adult worms were harvested after six weeks of laboratory maintenance. Observations made on water contact activities showed swimming, bathing and washing in the river and the stream as the high risk activities for Schistosoma mansoni infection.The study has shown establishment of transmission of schistosomiasis mansoni in Sanja Town. Therefore, appropriate integrated control measures need to be introduced to reduce morbidity in the population and also to control the transmission of schistosomiasis in the study area.
Perfil de compras federais de insulinas no Brasil: o impacto da entrada de biossimilares

Este estudo pretendeu descrever a aquisição, pelo governo federal, de insulinas presentes no Protocolos Clínicos e Diretrizes Terapêuticas (PCDTs) de Diabetes Mellitus (DM) DM1 e DM2, entre os anos de 2015 e 2020, analisando os valores pagos. As bases de dados do Sistema Integrado de Administração de Serviços Gerais (SIASG) foram consultadas. As variáveis analisadas foram: fornecedor, órgão comprador, volume comprado, preços unitários, gastos totais, modalidade de compras e marca. Estimou-se as Doses Diárias Definidas (DDD) adquiridas, gastos médios por DDD, Preços Unitários Médios Ponderados (PMPs) e gastos totais com esses medicamentos na série temporal. Foram analisadas 2.397 compras de insulinas no Brasil, realizadas entre 2015 e 2020, totalizando a aquisição pública de cerca de 121 milhões de unidades (frascos/ampola, refis e canetas), com um gasto de aproximadamente 1,4 bilhões de reais. Entre 2015 e 2020 observou-se uma redução do gasto médio por DDD de 63% nas insulinas NPH e 14% nas insulinas regulares. A maior parte das DDDs adquiridas (69%) eram medicamentos de referência e 31% das DDDs de biossimilares. É possível que as aquisições de insulinas biossimilares tenham contribuído para redução desses gastos, seja pelo aumento da concorrência, seja pelos PMPs inferiores.
New aerospace advanced cost effective materials and rapid manufacturing technologies

This project will focus on the development of technologies and methodologies which have the potential
to save costs and time across the whole life cycle of the aircraft (design, production, maintenance, overhaul, repair and retrofit), including for certification aspects. Moreover it will also target the integration of additional functions or materials in structural components of the aircraft, the increased use of automation.
The first proposed step is the introduction of the γ-TiAl alloy, a well known promising advanced material for aerospace
applications and a revolutionary manufacturing technology. Its specific stiffness and strength, as compared to its low weight,
potentially leads to large weight savings (50%), and therefore lower mechanical loads on thermomechanical stressed parts,
compared to the common Ni based superalloys. The integration of new material and new manufacturing technology will
positively impact several aspects of the manufacturing and maintenance chain, starting from the design, the production, the
repair).
The aim of this project is twofold:
- On one side the work will be focused on the development and integration at industrial of a IPR protected gas
atomization process for producing TiAl powders, whose properties must be highly stable from batch to batch.
Thanks to the stability of the chemical and granulometric properties of the powders, the application of the Rapid
Manufacturing technique to the production of TiAl components will be economically affordable. While this technique is
by now well-known, its main drawback resides in the scarce quality of the starting powders.
- The other main drawback for the wide industrial application of TiAl components is the integrated optimisation of all
the machining steps, that means the setting up of machine tool characteristics and parameters, cutting tool
geometry, substrate and coating materials, advanced lubrication technologies.
IMPROVED STABILITY FOR COAPPLICATION

A composition comprising a stable mixture of at least one stain resist agent, at least one soil resist agent, and at least one coapplication enhancer, said enhancer comprising at least one of an alkali metal salt; alkali metal aryl salt; ammonium salt; ammonium aryl salt; aryl sulfonic acid; urea; amide; alkylamide; dialkylamide; amide of C<SUB>1</SUB> to C<SUB>6</SUB> alkanoic acids or of C<SUB>2</SUB> to C<SUB>6</SUB> alkandioic acids; diamides of C<SUB>2</SUB> to C<SUB>6</SUB> alkandioic acids; cyclic imide of C<SUB>2</SUB> to C<SUB>6</SUB> alkandioic acids; C<SUB>3</SUB> to C<SUB>6</SUB> lactams, or combinations thereof, is disclosed.
Alfabetização científica: representações sociais sobre iniciação científica de professores PDE-PR em Química

O objetivo do presente estudo é realizar uma pesquisa do tipo “Estado da Arte” dos artigos científicos da área Química, produzidos por professores que promoviam Alfabetização Científica no Paraná. Os artigos foram realizados como parte do processo de formação continuada do Programa de Desenvolvimento Educacional do Paraná (PDE-PR). Essa produção está disponibilizada em Cadernos PDE-PR, turmas 2007 a 2016. A opção por identificar e sistematizar os resumos contidos em oito Cadernos PDE-PR, com leitura na íntegra dos artigos, visou selecionar e categoriza aqueles que contemplavam práticas que promoviam a Alfabetização Científica. Depois de sistematizados por modelos REDUC e configurado o Corpus, processaram-se os dados no software (IRAMUTEQ), o que possibilitou as análises de similitude e nuvem de palavras. A análise, com o aporte teórico da Teoria das Representações Sociais, indica que as produções apresentam alguns indícios sobre a Iniciação Científica na Educação Básica, os quais apontam para a Alfabetização Científica, além de evidenciar a baixa formação dos professores para práticas de Iniciação Científica, a precariedade dos laboratórios e a falta de uma Política Pública do estado do Paraná.
Direct and Indirect Organogenesis of Alpinia galanga and the Phytochemical Analysis

Alpinia galanga is a rhizomatous herb rich in essential oils and various other significant phytoconstituents. Rapid direct regeneration was obtained from the rhizome explants (15.66 ± 0.57 shoots) on MS media supplemented with zeatin at a concentration of 2 mg/l. The callus cultures of A. galanga were initiated from the rhizome explants on MS media supplemented with 2 mg/l each of BAP, 2,4-D, and NAA. The callus was analyzed for the presence of a vital phytoconstituent--acetoxychavicol acetate (ACA) associated with various biological properties. ACA was detected in the young friable callus as well as the stationary phase callus. Moreover, the induction of morphogenetic response in callus resulted in higher accumulation of ACA. The phytohormone withdrawal from the propagation media and the subsequent transfer of callus to BAP (2 mg/l) containing MS media has resulted in multiple shoot induction. The regenerated (indirect) plants have shown 1.6-fold higher ACA content (1.253%) when compared to the control plant (0.783%). Micropropagation of such conventionally propagated plants is very essential to meet the commercial demand as well as to ensure easy storage and transportation of disease free stocks.
Climatic impact on food trade resilience and security

Global climate change adversely affects crop yields and undermines humanity’s food security and resilience; while previous research has focused on regional agricultural adaptation, the opportunities and vulnerabilities of trade networks have remained less explored. In this vein, this research examines the joint climate, agro-environmental, and economic induced changes to the trade network topologies of five staple foods, i.e., maize, rice, wheat, barley, and soybeans, up to the year 2050 in the European and Mediterranean region. This proposed research adopts an interdisciplinary methodology drawing on crop yield modeling, economic trade modeling, network science, and quantitative scenario building approaches. More specifically, this research will enhance the International Model for Policy Analysis of Agricultural Commodities and Trade (IMPACT) Model with fitness network formation and gravity trade models to reveal the regional origin and destination of staple commodities. Through the enhanced model, the network topologies of current and future scenario staple food trade will be investigated and linked to the notions of resilience and security. Scenarios describing alternative dynamics of staple food trade network topologies for each crop will be developed through a comprehensive literature review focusing on agricultural trends, investments, and regional strategies and semi-structured interviews with agro-economists, agriculture policy specialists, and agricultural trade practitioners. The main innovations of this research project are the enhancement of the IMPACT model and in addition, the application of network analysis to interpret the ‘in-direct’ trade flow relationships which are not well captured by the current model. This will enable an analysis of climate change impacts on staple food trade in the light of the network-based configurations of network efficiency, redundancy, and modularity which are linked to the notions of food resilience and security.
A staged approach for identifying children with developmental coordination disorder from the population

The purpose of this study was to describe the motor, attention and intellectual characteristics of a population-based sample of children first screened for motor impairment and to discuss the recruitment and identification methods employed. A two stage cross-sectional, school-based survey was conducted to screen for children with motor coordination difficulties and to identify children with an existing diagnosis of attention deficit hyperactivity disorder/attention deficit disorder (ADHD/ADD). The identified children, and a random sample of typically developing children, were assessed to confirm or rule out the presence of developmental coordination disorder (DCD). Six thousand four hundred and seventy five children were invited to participate; 2943 children, with parental consent, completed the initial screening process. Two hundred eighty four children with possible motor impairment were identified. The parents of 113 children consented to a full assessment. Sixty eight children of the 113 children met diagnostic criteria for DCD, and 26 also had ADHD. Twenty eight of the 55 children who screened in with a diagnosis of ADHD were subsequently found to have DCD. The total number of children with confirmed characteristics of DCD was reduced after application of DCD diagnostic criteria. This study differs from others with regard to the additional screening for children with ADHD/ADD. The second stage assessment notably increased the number of children identified with both ADHD and DCD.
Intelligent toolkit for reconnaissance and assessment in perilous incidents

Many challenges arise in the immediate aftermath of a natural or man-made disaster. First responders must deal with pressing and dramatic challenges in a chaotic, dynamic, and dangerous environment while locating and rescuing victims and neutralising threats. They must make urgent decisions, but the zone can be large, complex, hostile, with many areas unsafe to explore. The lack of reliable information and the deep uncertainty present serious obstacles to a quick and effective response.

INTREPID aims to create a unique platform, seamlessly integrating Intelligence Amplification and eXtended Reality concepts, with unprecedented Smart Cybernetic Assistants and innovative deep indoor Networking and Positioning capabilities, to improve and accelerate the exploration and assessment of disaster zones. The project will validate its effectiveness, in iterative and complementary pilots, to support the rescue operations in areas that are complex or dangerous to explore. 

Always first on scene, first responders will be able to immediately start operations without having to wait for specialized teams or for the zone to be fully secured. When these teams arrive, first responders have already used INTREPID to provide them with reliable information and effective assistance. The result is an immediate and targeted response that will allow faster, more effective and safer operations.

The consortium consists of world-class research centres and SMEs, coordinated by an industrial with a leading position in the security market. It will follow a user-centric methodology involving many first responders, and an international Advisory Board and Open User Group ensuring diversity. Social, ethical and legal constraints will be carefully considered during the project’s lifetime. 

The project will design and implement a training curriculum and an innovative evaluation framework along with an ambitious communication and dissemination plan, preparing the ground for successful exploitation.