SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Reusable laundry detergent

ReLaDe, an Estonian SME, is developing a reusable laundry washing system, based on novel utilization of enzymes. The ReLaDe innovation has the potential to completely replace the current hazardous detergents and bring disruptive innovation into a market that has been in technological standstill for decades. The innovation will reduce the environmental impact of doing laundry by cutting CO2 emission, decreases the amount of chemical pollutants in wastewater, improve people’s health and offer a novel concept for uptake of nanotechnology by reusing enzymes. 
Although enzymes are biodegradable and environmentally harmless they are currently just one of many ingredient in detergent formulas, which are still dominated by toxic and harmful chemicals. The core innovations relies in conjugation of enzymes to magnetic nanoparticles. The method, so far used in science and pharmaceutics, results in complex enzyme properties – a biological activity and magnetic functionality. ReLaDe´s innovative immobilization of the bioactive compound to a solid particle significantly increases enzymes stability and activity. Moreover, the magnetic functionality enables the recovery and reuse of the enzyme to make full use of its potential as only a fraction is exploited in solutions currently on the market. ReLaDe conducted tests suggests that one load of biological enzyme laundry agent could be used in one household approximately for 12 months until additional agents are required to be added. 
ReLaDe´s innovation has already gained global attention by winning third price in world´s largest cleanteach business idea competition. ReLaDe innovation development has reached TRL 6. The specific objectives of the project are business plan development, partner search and testing of the enzyme recollection device.
A computational methodology for the creation of photorealistic mosaic using breccia tiles

A comparison based tile classification technique has been developed and applied computationally in order to compile a mosaic, which constituting tiles emplaced as to form a particular figure. The mosaics are generated using the surficial shapes of the tiles. Unlike the conventional mosaic tiling process, geometric properties of the tiles do not have any role for the proposed methodology. Therefore, square breccia rock tiles, having variable surface appearances, have been used by processing with the developed algorithm and lined up as to form targeted sample images. The technique showed satisfactory results even with a limited number of tiles in the database. The compilation of the mosaic with the proposed methodology is a very fast and cheap process, which makes it ideal to follow the different requirements of the individual customers and eliminates skilled workforce in the production. Since the mosaic contains different ratios of breccia tiles, having variable surface appearances, the gap between the market prices of the tile groups has been eliminated and an extra value to the final product has been added by attributing an artistic value. The technique offers practically no size limitation for a mosaic, which makes it suitable for large coverings such as ones in museums, lobbies and even for open spaces. The methodology presented in this study allows creating photorealistic mosaics having higher engineering properties
Conference Report: AAPS and US FDA Crystal City V meeting on Quantitative Bioanalytical Method Validation and Implementation: feedback from the EBF

Crystal City V meeting on Quantitative Bioanalytical Method Validation and Implementation: 2013 Revised US FDA Guidance 3–5 December 2013, Hilton Baltimore, MD, USA The meeting provided an opportunity for Industry and regulators from the US FDA to discuss the recently published revised draft FDA Guidance for Industry on Bioanalytical Methods Validation during the 90 day review period. Key perspective and philosophical positions were shared leading to a healthy exchange of views and ideas on topics in the revised document. Discussions covered all aspects of bioanalytical method validation and method utilization. However, the main dialogue was focused on chromatographic methods, ligand-binding assay methods and biomarker analysis. The resulting open debate led to greater understanding of the document, but also provided clear feedback, including the request on harmonization with approved Bioanalytical Methods Validation guidance‘s release from other health authorities, as well as the consensus view between industry and the FDA. Members of the European Bioanalysis Forum summarized prospective discussions during the meeting in Baltimore; however, this Report is not intended to constitute the official proceedings from the meeting, which are expected to be published later this year.
Solitary Pulmonary Nodules

DR. FLORES, MD THE CHANGING PRACTICE OF NODULE MANAGEMENT DR. MARSHALL: How has lung cancer screening changed your practice? DR. SWANSON: I think what has changed is we’re seeing smaller, more peripheral nodules, and we’re also seeing multiple nodules. Twenty years ago, you might see a 3-cm lesion solitary and now you’ll see a 1.2-cm lesion in the right lower lobe and then a 3or 4-mm lesion in the left upper lobe or something in the right upper lobe in addition. How do you triage different multiple lesion scenarios in addition to just ground glass vs solid. DR. BAUER: I think the number has definitely increased for 2 reasons. One, there’s lung cancer screening that’s being done in the high-risk patients, but then it seems as though the vast majority of people who come into the emergency room end up with a CT of something. DR. MARSHALL: I have found that just the thickness of the slices in CT, as they have become so fine, these scans are picking up 3-mm nodules, 4mm nodules, which at times are just intraparenchymal lymph nodes. These are usually in patients who are being followed with a previous malignancy. I don’t recall seeing these a decade ago. DR. SWANSON: Agree. The high-resolution CTs have shown us a lot of pathology. But I think if they’re small and new, it’s easy to say “let’s see what happens to this in 3 months or 4 months.” If you see a spiculated mass or a concerning mass and then maybe 1 or 2 others, do you just focus on the one you’re worried about and does it affect what kind of operation you’re going to do, how you’re going to work it up? I’m more aggressive with mediastinal evaluation if there are multiple nodules. DR. FLORES: I think the most important thing is to figure out what is real and what is not real. Are you sitting on something that’s going to develop into
NewHaapKome2020 — growth and global competitiveness with investment in development

The main objectives of the NewHaapKome2020 project are to raise the production capacity, production equipment and digital working environment of the Haapajärvi plant to a level that promotes growth and internationalisation. The aim is also to improve our global competitiveness by developing the operating and management model of the digital order-supply chain. An important part of the NewHaapKome2020 project is to support the comprehensive implementation of Haapajärven KoME Oy’s corporate-level NewKome2020 development programme.
Enhancing aesthetic reception of contemporary music through active tempo control with physiological monitoring

Complex contemporary music (CM) is the crucible for musical invention that exemplifies human creativity. It forms the lifeblood of musical cultural evolution, but can be alienating to the uninitiated. In EAR Stretch, we propose to help non-specialized listeners gain a deeper appreciation for CM through embodied interaction with temporal expression of the music. When communicating music, skilled performers often help listeners make sense of the music through expressive prosodic inflections of timing and tempo. In familiar music, listeners can often recognize the pulse and tap a foot along to the expressed beat. But in CM, listeners’ internalization of the beat and subsequent embodied reactions may be limited. The embodied cognition that comes from physically engaging with time—including organization of intrinsic brain activity and changes in perception—may be lacking in CM listening, contributing to poor reception. We hypothesize that empowering listeners to physically control the temporal expression of CM will lead to improved reception of the music as measured by neural and physiological changes and aesthetic evaluation of the music. Our main objective is to determine the impact of motor-based temporal engagement with CM on the listener-performer’s reception of the music. Acoustic- and complexity-matched CM compositions will be created specially for a psychophysiological study comparing normal listening to interactive listening with tapping-based temporal control. Objective measures, neural and physiological responses, will probe the underlying causes of subjective aesthetic evaluations and elucidate the roles of arousal, attention, and entrainment in these sources. Positive impact of interactive, embodied engagement with CM will transform the CM landscape, inspire the redesign of concert experiences, promote social inclusion, and propel CM into the musical vernacular, inciting cultural and intellectual development.
Earth resilience in the anthropocene (era)integrating non-linear biophysical and social determinantsof earth-system stability for global sustainabilitythrough a novel community modelling platform

In 2015, the UN Sustainable Development Goals (SDGs) and the Paris Agreement on climate recognised the deteriorating resilience of the Earth system in the Anthropocene. Maintaining Earth in the interglacial state that enabled the world’s societies to evolve over the past 12,000 years will require industrialised societies to embark on global-scale social transformations. Otherwise, there is a real risk of crossing tipping points in the Earth system triggering abrupt and irreversible changes. 
A critical gap is that although nonlinear social and biophysical dynamics are recognized, we remain trapped in linear thinking. Global modelling and analyses – despite much progress – do not adequately represent nonlinear processes and abrupt changes, and social responses to sustainable development are incremental.
The goal of this project is to fill this gap, by exploring the biophysical and social determinants of the Earth’s long-term stability, building up a novel community modelling platform for analysis of nonlinearity and abrupt shifts, and informing global sustainability policy processes. The project will investigate two hypotheses: 1) Interactions, feedbacks and tipping points in the biosphere could, even in the absence of continued high emissions from fossil-fuel burning, tip Earth into a new state, committing to global warming over 2C and possibly beyond 4C; and 2) Only nonlinear societal transformations that aggregate to the global scale can assure long-term stability of the Earth and keep it in a manageable interglacial state. 
The five research tasks are Task 1: analysis of nonlinear biosphere dynamics governing Earth resilience. Task 2: integrating nonlinear dynamics in World-Earth models. Task 3: exploring tipping points in social systems for large-scale transformation. Task 4: backcasting pathways for achieving the SDGs. Task 5: integrating World-Earth dynamics into online learning and virtual-reality games, e.g. Planet3 and Minecraft.
Seismic behavior of dual function slitted shear wall

The concept of seismic structural control was used to design a new type reinforced concrete shear wall, the dual function slitted shear wall. Connectors are installed in vertical slits in the slitted shear wall to provide the dual function slitted shear wall with greater stiffness and capacity for small and moderate earthquake intensities. The wall becomes a slitted wall with the ductile flexure failure mode when the connectors fail during severe earthquakes. Seven specimens were tested to study the seismic behavior of the dual function slitted shear wall. The results showed that the connector controlled function well and provided better seismic behavior.
A Review of Wireless and Satellite-based M2M Services in Support of Smart Grids

Abstract. The Smart Grid (SG) is an evolution of the electricity network that integrates the activities of power consumers, power generators, distribution grid, and devices connected to the grid (e.g., substations, transformers.) Machine-to-Machine (M2M) technology is designed for automated data exchange between devices, and thus has applicability to SGs. With M2M technology, organizations track and manage assets; inventories; transportation fleets; oil and gas pipelines; mines; wide-spread infrastructure; natural phenomena such as weather conditions, farm production, forestry condition, and water flows; and, as noted, SGs. Wireless communication is a staple of M2M. These wireless technologies range from unlicensed local (so called ‘fog’) connectivity, to licensed 3G/4G/5G cellular, to Low Earth Orbit (LEO) satellites. All of these technologies are relevant to the SG. Utilities have started to gradually support M2M and Supervisory Control And Data Acquisition (SCADA) systems over satellite links. This article focuses on wireless and satellite-based M2M services, as applicable to the Smart Grid, including the use of Internet of Things (IoT), particularly for the transmission and distribution space (TD some comparisons to wireline solutions are also discussed.
digitalLIFE4CE Fostering innovation in integrated healthcare systems solutions

The R&I fragmented innovation & cooperation landscape of CE strongly affect the cooperation mechanisms among innovation actors and weaken the transfer of discoveries and knowledge along the digital healthcare sector value chain. The digitalLIFE4CE project creates a CE area of excellence in the field of digital integrated healthcare systems solutions where flexible, solution oriented cooperation mechanisms can be rapidly activated and transferred to all its strategic actors. Thus availability of joint knowledge assets in the CE area in the field of integrated digital solutions will change: evidence of existing excellence cases, feasibility of effective linkages supported by robust long term oriented methodologies, active connected integrated digital healthcare excellence hotspots, related long term sustainability and related effects on the whole CE area will be guaranteed. Mapping & visualization Toolbox (OT1.1), related Strategies and Action Plans (OT1.2), Learning Toolbox (OT2.1) & Innovation Network Alliances (OT2.2), Hub of Digital Healthcare Excellence Spots (OT3.1) & transnational roadmap to support their cooperation (OT3.2), Strategic CE Task force (OT4.1) & a Capitalisation Agenda (OT4.2) will provide benefits to public & private actors of the digital integrated healthcare value chain. The innovative multi actor level & quadruple helix approach is based on: 1) capitalization (Healthcare Excellence Spots), 2) strategic connections (CE Digital Care Networks), 3) demonstration of cooperation & impact potential (Pilot & Demo Cases), 4) long term innovation schemes (Transnational Strategy & Roadmap). digitalLIFE4CE brings together 7 CE areas and the most appropriate mix of policy / R&D / implementation relevant actors which will allow to jointly tackle the complex challenges within the innovation landscape of integrated health systems overcoming the limitations of regional or national approaches.
Work on demand: contracting for work in a changing economy

Labour law as a scholarly discipline is widely believed to be in crisis. Since the time of its birth, both the nature of working relationships and the context within which they are formed and regulated have changed significantly. The difficulty for scholars is that old concepts don’t perform the function anymore of making sense of the field. Old arguments about the need to protect workers’ interests are met with counterarguments, informed by neoclassical economics, that protective measures inhibit economic growth and increase unemployment. 
The WorkOD project aspires to nothing less than a fundamental transformation of the discipline of labour law across the whole of Europe and beyond. Understanding the crisis to have at its heart a crisis of methodology, it aims to develop a new methodology for the study of the key legal concept of the contract for work. It aims to explain trends in the field of work organisation and working relationships and to assess the significance of particular labour market institutions to the achievement of policy goals in a way that is useful to scholars and policy-makers. And it aims to pave the way for future contributions by scholars to policy debates, so that they may influence in positive ways the identification of new economically and socially sustainable solutions to the problem of the division of responsibilities and risks between workers and those for whom they work. 
In a marked departure from the state of the art, the project defines contracting for work as an instance of economic, social and legal behaviour, influenced in a variety of ways by the institutional context within which it proceeds. Rejecting the reframing of labour law according to a full blown market paradigm, it argues instead for the utility of sociological methods. Its development of a new methodology begins from a combination of micro and macro perspectives, and a synthesis of approaches drawn from economic sociology, political economy and the sociology of law.
Srm: synchronous reluctance motor. introducing a new lifting technology in the elevator market

The market for lifting systems is nowadays dominated by gearless machines. Among them there is a type of machine based on the use of Neodymium permanent magnets. However, the raw material with which these magnets are made is subject to large fluctuations in the price because there is a very high dependence on the unique source of extraction, China. 
In addition, PM gearless motors are related to reliability problems due to the lack of knowledge about the lifespan of the magnets, as well as performance related to high operating temperatures (above 140ºC) and oxidation due to its iron components. 
The elevators market size is expected to grow from € 75,000 million (2015) to € 105,831 million by 2021, at a CAGR of 6.01% based on an increasing demand in Asia and Pacific area. 
Italian Top Gears SRL, is an Italian SME located in Bolzano di Albinea (Reggio Emilia) that is dedicated to design, manufacture and distribution of elevator traction machines with the state-of-the-art technologies for the worldwide market. 
Taking all of this into account, the company has patented a novel alternative system to the previous one, with similar outputs in speed, comfort and efficiency, but with a much more effective performance in the terrain of reliability and security. But above all, what makes highly interested this new system is up to 40% savings in motor costs. 
The innovation lies in the use of a synchronous reluctance electric motor (SRM) as a traction unit, following the requirement and needs of the lift industry. 
The main benefits obtained with SRM are: lower prices per unit, no electrical encoder needed in system, use of IoT applied to the lifts, reduced motor size, low maintenance, 50% lifespan increase, estimated energy savings of € 3239 and reduction of the carbon footprint of the process. 
This project is aiming to achieve profits around € 3.7 M and hire 9 new employees after 5 years in market, reaching a ROI (return of investment) of 2.3 per euro invested.
Investigation of Pharmacokinetic Data of Hypericin, Pseudohypericin, Hyperforin and the Flavonoids Quercetin and Isorhamnetin Revealed from Single and Multiple Oral Dose Studies with a Hypericum Extract Containing Tablet in Healthy Male Volunteers

Hypericins, hyperforin and flavonoids are discussed as the main components contributing to the antidepressant action of St. John's wort (Hypericum perforatum). Therefore, the objective of the two open phase I clinical trials was to obtain pharmacokinetic data of these constituents from a hypericum extract containing tablet: hypericin, pseudohypericin, hyperforin, the flavonoid aglycone quercetin, and its methylated form isorhamnetin. Each trial included 18 healthy male volunteers who received the test preparation, containing 900 mg dry extract of St John's wort (STW 3-VI, Laif 900), either as a single oral dose or as a multiple once daily dose over a period of 14 days. Concentration/time curves were determined for the five constituents, for 48 h after single dosing and for 24 h on day 14 at the end of 2 weeks of continuous daily dosing. After single dose intake, the key pharmacokinetic parameters were determined as follows: Hypericin: Area under the curve (AUC(0-infinity)) = 78.33 h x ng/ml, maximum plasma concentration (Cmax) = 3.8 ng/ml, time to reach Cmax (tmax) = 7.9 h, and elimination half-life (t1/2) = 18.71 h; pseudohypericin: AUC(0-infinity) = 97.28 h x ng/ml, Cmax = 10.2 ng/ml, tmax = 2.7 h, t1/2 = 17.19 h; hyperforin: AUC(0-infinity) = 1550.4 h x ng/ml, Cmax = 122.0 ng/ml, tmax = 4.5 h, t1/2 = 17.47 h. Quercetin and isorhamnetin showed two peaks of maximum plasma concentration separated by about 3-3.5 h. Quercetin: AUC(0-infinity) = 417.38 h x ng/ml, Cmax (1) = 89.5 ng/ml, tmax (1) = 1.0 h, Cma (2) = 79.1 ng/ml, tmax (2) = 4.4 h, t1/2 = 2.6 h; isorhamnetin: AUC(0-infinity) = 155.72 h x ng/ml, Cmax (1) = 12.5 ng/ml, tmax (1) = 1.4 h, Cmax (2) = 14.6 ng/ml, tmax (2) = 4.5 h, t1/2 = 5.61 h. Under steady state conditions reached during multiple dose administration similar results were obtained. Further pharmacokinetic characteristics calculated from the obtained data were the mean residence time (MRT), the lag-time, the peak-trough fluctuation (PTF), the lowest observed plasma concentration (Cmin), and the average plasma concentration (Cav). The data obtained for the five consitituents generally corresponded well with values previously published. The trial preparation was well tolerated.
Tecnología de Realidad Aumentada en el Inter - Aprendizaje

La presente investigación realizó el análisis de las repercusiones que sobre el Inter– aprendizaje tiene la implementación de la Realidad Aumentada en el aula de clase de los estudiantes de Segundo de Bachillerato de Colegio Fiscal 17 de septiembre del Cantón Milagro. Abordó los fundamentos teóricos referentes a las dos variables. Presentó las ventajas y la aplicabilidad de la realidad aumentada con otras áreas. Se aplicó una investigación descriptiva para determinar los factores que inciden en el mejoramiento del aprendizaje participativo en el aula de clase. Su aplicación obtuvo grandes beneficios al aplicar una guía práctica y didáctica como apoyo educativo que fue seguida por los estudiantes. La investigación logró demostrar cómo la aplicación de realidad aumentada generó un interés especial por aprender, motivó la participación de todo el grupo de trabajo y facilitó la aprehensión del conocimiento
Changes of IL-6 level in bronchoalveolar fluid in patients with acute exacerbation of COPD before and after the treatment with tiotropium bromide, and its significance

Objective: To investigate the changes and significance of IL-6 level in bronchoalveolar fluid in patients with acute exacerbation of COPD before and after the treatment with tiotropium bromide. Methods: The IL-6 level in bronchoalveolar fluid of 45 COPD patients with acute exacerbation and 15 healthy people (control) were determined by using double-antibody sandwich enzyme-linked immunosorbent assay. Results: The IL-6 level in bronchoalveolar fluid of COPD group before the treatment were significantly higher than those after the treatment with tiotropium bromide, and both were higher than those of control group. Conclusions: IL-6 contributes to the development of COPD and its continuous high level may be one of the important factors resulting in chronic airway inflammation.