SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Osmotic wearable bolus injector (owbi) for viscous drug delivery

With more drugs coming onto the market as combination products, i.e. drug products paired with delivery devices pharmaceutical companies are paying closer attention to integrated delivery systems. Due to: 1) the trend in the change in drug formulations, in order to migrate from intravenous to a more cost-effective and convenient subcutaneous (SC) drug administration; and 2) the trend in moving from synthetic derived drugs to biologically drugs that are more complex and have higher viscosity and therefore require delivery of larger doses; resulted in the need for a new class of injection devices - wearable bolus-injectors (WBIs). WBIs are prefilled, disposable devices that are worn on the body of a patient during the SC self-administration of a large dose of medication. The WBI market is estimated to grow in CAGR of 170% between 2015 – 2020 and achieve €6.9Bn by 2025, and pharmaceutical companies are actively seeking for reliable and cost-effective WBIs, providing optimal injection performance at an attractive unit cost and low cost of customization.

Subcuject ApS (SCJ) is a medical device company set to commercialize a new class of WBIs - Subcuject - that makes use of the simple, predictable and strong force of nature: osmotic pressure. Unlike the current WBIs, Subcuject is fully mechanical, bearing no electronic components, resulting in a more flexible, reliable and eco-friendly device at a remarkably lower cost than competitor’s (75 - 86% cost reduction). 

SCJ business strategy is based on establishing multiple licensing deals (depending on the drug type, disease, region) with pharmaceutical companies. The Subcuject device is expected to significantly enhance SCJ’s profitability, with an expected accumulated profit of €97M, 5 years after project completion. Moreover, the successful achievement of the project objectives will assist SCJ to be a leading company in the WBI device segment in a market today dominated by U.S. companies.
High speed, cost effective optical communications module enabling the next generation of ethernet 400 gbe

Project “RocketChip” will develop a 400 Gb/s optical communications module for optical fibre transmission. The core technology for this high speed, communications module is Photonic Integrated Circuits (PIC). This technology allows the transmit- and receive-functionality of the system to be integrated onto single chips. The size of the integrated chips will allow the module size to meet the requirement of an industry standard common form factor. This will make it physically compatible with current system vendors’ products. PIC chips are key to the next generation of telecommunications networks that will demand even higher performance, smaller size and lower cost. EFFECT Photonics are leaders in the field of Photonic Integrated Circuits (PICs) and will combine their PIC technology (based on technology spun out from TuE) with their unique and low cost PIC chip packaging technology (15x cheaper than traditional gold box packaging). This will give EFFECT Photonics a significant cost advantage over competing technologies and products, making it economically viable to manufacture the product in Europe. On completion, this 2 years and 9 months project will deliver a market ready and cost effective 400 Gb/s optical communication module. The project is a key enabler of 400Gb Ethernet (400 GbE), providing a timely solution to the urgent, unrelenting issue of rapidly increasing bandwidth demand, converting world leading European research and innovation into €148M of revenue and securing Europe’s position at the forefront of an emerging Photonic Integrated Circuit industry. This project will enable EFFECT Photonics to develop a leadership position in the next generation of PICs and hence develop a strong, profitable and growing business in Europe.
INCA Central Europe - Integrated nowcasting system for the Central European area

Weather and especially severe weather is responsible for many natural disasters causing damage and loss of life. Weather forecasts are an essential part of early warning systems and consecutive actions within civil protection schemes, road management and flood protection. In the last years nowcasting, which is the forecast for the next hours, has improved significantly. Disasters at small time and space scales like hail or flash floods etc. as well as sub-events within large scale catastrophes like flooding and storms can be detected and managed. Nowcasting plays an increasing role in risk prevention, but its realisation is a highly complex and integrated task INCA CE will implement a transnational information system as well as applications for different socio-economic sectors to reduce risks of major economic damage and loss of life. Not only civil protection but also stakeholders from economic sectors are in a growing need of accurate and reliable short-term forecasts.

The INCA-CE project specifically has the goal of setting up a web-based trans-national weather information system that uses state-of-the-art nowcasting methods developed by several countries. It will enable users in the public and private sector to take into account weather-related risks and hazards in a more timely fashion, more precisely, and in greater geographical detail. More precise information about heavy rainfall and associated rise of water levels (flooding) will help set up improved procedures in the management of mitigating measures for the protection of buildings, roads, and other infrastructure. Civil protection will benefit from a more comprehensive assessment of meteorological threats, and a more detailed and timely forecast, leading to more efficient warning protocols and dissemination strategies. Road safety will be enhanced by a more detailed road weather forecast made available both to the road management authorities as well as to the general public.
Dynamic range extension of hybridization sensors

In hybridization based nucleic acid sensors the stringency of hybridization poses a challenge to design and experiment. For a given set of experimental parameters the affinity window of probe-target interaction is always limited and vice versa for a given probe set design, changes in experimental conditions can easily bring some measurements out of detection range. In this paper we introduce and apply a strategy to extend this dynamic range for affinity sensors, sensors which measure the amount of hybridized molecules after equilibrium is reached. The method relies on concepts of additivity of nucleic acids hybridization free energies and on equilibrium isotherms. It consists in combining the measurements from probes with different lengths, by appropriately rescaling the measured signals. We test the validity of the approach on experiments and show that by combining probes with hybridizing regions of length 21, 23 and 25 nucleotides we manage to extend the dynamic range of the intensity signals by a factor of 25. The presented concept is easy to extend, platform free and applies to any hybridization based affinity sensor.
COLUMN SHOE

The invention relates to a column shoe (1) for securing building elements of concrete such as concrete columns (2) to a base (3). The column shoe (1) comprises a bolt housing (4), wherein the bolt housing (4) comprises a baseplate (5) provided with a through bolt hole (6) for an anchor bolt (7), and wherein the bolt housing (4) comprises an upper structure (8) connected to the baseplate (5), and at least one attachment unit (12) attached to the bolt housing (4) for securing the column shoe (1) and a building element together. The bolt housing (4) being provided with at least one socket member (9) for attaching an additional anchoring means (10) such as a dowel or a bar to the column shoe (1) in addition to at least one attachment unit (12) and in addition to an anchor bolt (7).
LIGHTING DEVICE AND METHOD FOR PRODUCING A LIGHTING DEVICE

The invention relates to a lighting device (1) having at least one body (4), particularly a heat sink, having an outer contact surface (24) and a light source carrier (6), particularly an LED carrier pressed onto the contact surface by means of at least one pressing element (43), wherein the pressing element can be attached to the lighting device (1) by means of at least one rotary motion. Said method permits the production of a lighting device with at least one body having a contact surface for a light source carrier, wherein the light source carrier is pressed against the contact surface of the lighting device by means of rotating a pressing element.
Preliminary investigation on vectors of mosquito-borne diseases in Yiwu,Zhejiang

Objective To identify the major vectors of mosquito-borne diseases and their geographic distribution after the outbreak of dengue fever(DF) in Yiwu,providing basis for further prevention and control.Methods Light traps and dippers were used to collect mosquito adults and larvae,respectively,based on random sampling.Results At least 8 species in 4 genera belonging to 2 subfamilies were found in the region.Culex pipiens pollens coquillett was the dominant species found in 234 villages and 13 towns.Although there were few Aedes albopictus(Skuse) and other species collected from the traps,it was the only vector of DF in Yiwu that distributed in 10 towns and 18 villages,a result of the breeding place survey on mosquito larvae. Ae.albopictus larvae accounted for the highest proportion(51.7%) of the mosquito population,followed by Cx.tritaeniorhynchus, while other species including Cx.mimulus were limited.Conclusion In view of the widely distributed vectors of mosquito-borne diseases in Yiwu and regional concentration of high density,breeding sites should be eliminated to cut off the primary transmission route of vector-borne diseases in order to lay a sound foundation for further prevention and control.
An innovative, thin and quick-to-install prefabricated prefabricated ‘click-in’ underfloor heating system capable to be installed directly on the existing floor and connectable to the radiator system.

Across the EU, there is a need to increase the energy efficiency of heating and cooling systems as 50% of all energy consumption across the EU is spent on heating and cooling. Underfloor heating systems can significantly contribute to this. However, currently, underfloor heating system have the following challenges:
•	Require invasive demolition works that can take up to several months
•	Lack leakage detection system 
•	Results in increased floor thickness 
•	Requires architectural changes 
•	Higher energy bills due to high thermal inertia
Heatile S.r.l has developed HEATILE, an innovative easy-to-install prefabricated underfloor heating system resolving the problem of invasive demolition works, high retrofitting costs, floor thickness and liveable heights and leakage detection. Our solution is simple to install in comparison to competitors’ products and does not require extensive labour. Our target users are the system installer (Architect, Designers and Contractors) and the end-Users, (Building Owners and Occupants). Our solution, provides the following:
•	Boost in productivity for installers: The easy to install modular solution cuts installation time by more than 90% thereby allowing more jobs to be done.
•	Reduction in installation costs for building owners: Installation costs are reduced by 15-25% as there is no need for demolition works during retrofitting. 
•	Reduction in energy bills: HEATILE is a low thermal inertia system, heating a home in only an hour instead of the 12hrs.
•	Reduction in Carbon emissions: Our solution decreases household energy usage hence reducing CO2 emission.
By the 5th year of commercialisation, we expect to sell about 160,000sqm generating a cumulative revenue of €26.60-m and cumulative EBIT of €2.545-m creating 22 jobs.
Constitutive parameter analysis of left‐handed dual‐star split‐ring resonator metamaterial for homogeneous infinite slab

A new shaped backward wave periodic dual-star split-ring resonator (DSSRR) is proposed based on the equivalent transmission line theory. The proposed artificial DSSRR design structure produces a wide band from 7.5 to 9.5 GHz, and very high rejection (47 dB) with sharp cut-offs in the forbidden band. To ensure the retrieval of electromagnetic parameters, primarily a single unit cell is considered. Then, the periodic four unit cells are decomposed to investigate the excitation metamaterial properties. The constitutive properties of the dispersion diagram exhibited very unusual characteristics and separated into different directions in balanced and unbalanced conditions in order to excite propagation in different modes. The dispersion of left-handedness group velocity exhibits the parallel direction of the poynting vector and high gain in higher frequency regions, whereas the phase velocity demonstrates the anti-parallel direction of the poynting vector obtained from the resonance frequency regions. The overall electromagnetic parameters of negative dielectric constant, resonance permeability, anti-parallel phase and group velocity, and refractive index confirm that the proposed periodic DSSRR artificial structure to be the most suitable for metamaterial behaviour and characteristics.
Regulatory mechanisms controlling a new mechanical epithelial to mesenchymal transition in zebrafish

While cancer biologists have long assumed that developmental Epithelial to Mesenchymal Transitions (EMT) transcriptional programs also control cancer metastasis, our lab has recently found that cancer EMT instead uses a mechanical-based two-step process. Typically, epithelial cells fated to die get extruded apically into the lumen. However, oncogenic mutations that drive metastatic cancers hijack this process, causing cells to either form masses or to extrude basally back into the tissue at separate sites. Basal extrusion causes transformed cells to not only invade but also to lose their entire apical membranes, including their E-cadherins, which are critical to epithelial identity. Later, invading cells migrate using a stable-bleb type motility typical of cells in confined spaces and then transdifferentiate into a variety of different cell types. While our lab has established that basal extrusion causes invasion and loss of epithelial identity, it is unclear what later causes cells to become mesenchymal. Using the transparent zebrafish embryo, I will investigate the mechanisms that promote the second step of EMT by answering the following questions: 1) Does mechanical stress following basal extrusion cause trans-differentiation of invading cells? 2) What programs promote EMT of transformed cells? 3) What environments allow invading cells to colonise specific tissues? Our new EMT model represents a paradigm shift in our understanding of how tumour cells initiate metastasis, survive in different environments, and become distinct cell types. Thus, addressing these aims could impact our ability to finally treat metastatic disease.
Sweet pepper harvesting robot

In modern greenhouses there is a high demand to automate labour. The availability of a skilled workforce that accepts repetitive tasks in harsh greenhouse climate conditions is decreasing rapidly. The resulting increase in labour costs and reduced capacity puts major pressure on the competitiveness of the European greenhouse sector. Present robotization of  this labour has entered an high level of technological readiness. However, a gap remains which halts the transition from science to economic and societal impact; the so called ‘Technological Innovation Gap’. In the EU-FP7-project CROPS extensive research has been performed on agricultural robotics. One of the applications was a sweet pepper harvesting robot. It was shown that such a robot is economically and technically viable. The proven hardware and software modules (TRL:6) developed in CROPS will be used as the groundwork. The successful CROPS software modules based on the Robotic-Operating-System (ROS) will be maintained and expanded in SWEEPER. Also the gripper end-effector will be retained. This patent pending module is able to grasp the sweet pepper without the need of an accurate measurement of the position and orientation of the fruit. From the CROPS project, also gained knowledge will directly be put to benefit. In several experiments, it turned out that different growers use different cropping systems ranging in crop density. In SWEEPER, the cropping system itself will be optimized to facilitate robotic harvesting. In CROPS it was concluded that instead of a 9DOF, a 4DOF robot arm is sufficient , greatly reducing costs. To improve the level of robotic cognitive abilities, plant models will be applied to approximate  location of sweet peppers. This “model-based vision” will increase and speed up fruit detection. Based on the insights of CROPS, sensors will be placed onto the gripper only. Also a LightField sensor will be introduced which is able to record both colour and 3D information simultaneously.
Technologie innovante pour la pasteurisation des jus de fruits NFC frais pour le déversement aseptique

Le projet comprend le développement d’innovations de procédés, dans le domaine du processus innovant de pasteurisation par micro-ondes, le dégazage par pulvérisation de jus NFC frais à partir de fruits domestiques pour le déversement aseptique et la construction et la validation d’une ligne pilote innovante dédiée, qui permettra la production de jus NFC avec une longue durée de conservation, des paramètres sensoriels et nutritionnels accrus par rapport aux jus NFC disponibles sur le marché. Le processus technologique développé et la ligne pilote qui le reproduit permettront au demandeur de réduire l’oxygène dans les jus et les enzymes natives des tissus, ce qui réduira l’oxydation et la dégradation des substances actives et maintiendra ainsi la valeur nutritionnelle des jus plus longtemps. Les paramètres du processus technologique seront sélectionnés et optimisés sur la base d’un certain nombre d’analyses physicochimiques, sensorielles et microbiologiques réalisées sur des échantillons de boissons lors de simulations et d’essais technologiques sur des sous-systèmes clés individuels de la nouvelle technologie dans des conditions proches du réel. Les connaissances acquises serviront à concevoir la version finale du procédé pour chaque type de jus testé et appliqué au prototype d’une ligne pilote unique testée et validée sur une échelle proche du réel. Le prototype de la ligne technologique comprendra une machine de dégazage par pulvérisation, un module de pasteurisation par micro-ondes en flux, un système de mélange de jus, d’embouteillage aseptique, de soufflage d’unités de conditionnement (bouteilles PET) immédiatement avant le déversement de jus, et un système avancé de logistique et d’emballage internes. Article 25 du règlement (CE) no 651/2014 du 17 juin 2014 déclarant certaines catégories d’aides compatibles avec le marché intérieur en application des articles 107 et 108 du traité. C’est tout. UE L 187/1 du 26.6.2014);
Multifunctionnal cabin rest area

Airbus has defined the need for a multi-functional cabin rest area, under JTI-CS2-2016-CFP04-AIR-01-24 Program Area AIR – WP A-5.1.1. Zodiac answers to this call with project CRiSTA (Cabin ReST Area). Zodiac has an excellent track record in cabin concepts, crew rests  and galleys (almost 90% market share of galleys in single aisle aircraft), and within the Zodiac group there is knowledge on all required building blocks such as: flexible cabin concepts, light-weight storage, high comfort cabin attendant seats, lighting and a wide variety of systems.
The concept envisaged by Zodiac, compliant to the call text, is a flexible, reconfigurable area with minimally (single aisle aircraft) one seat, one bed, a working position and medical equipment, all stowed and folded innovatively in an isolated space. The solution shall be intended for future large aircraft and be scalable to all existing platforms. The space can be used as crew rest, work station, medical area and cultural needs area (meditation, nurturing or prayer).
The project will impact resource efficiency (efficient weight/space use, less flight diversions for medical events) and societal needs with increased passenger comfort for passengers with different cultural backgrounds. 
Zodiac has an excellent track record in obtaining user requirements from interviews with users and use of its cabin experience center in Alkmaar, The Netherlands. Based on requirements, building blocks will be defined and integrated for testing in a representative cabin environment. Additionally also regulatory impact will be defined (medical emergencies, crew resting times).
The CRiSTA total grant request to the CS2 JU is € 547.324,- and the total eligible project budget is €781.892,- for the whole consortium consisting of one Zodiac Business Unit which contains two legal entities, in The Netherlands and in the Czech Republic. The project will be conducted over 47 months in close alignment with the overall Airframe ITD needs.
Individualised cognitive and motor learning for the elderly

This project aims to create a method with high efficacy aimed at providing an individualised approach to motor sequence learning in elder adults. The current problem is that the provision of motor learning programs have little/no consideration of individual cognitive and motor differences, and therefore varying levels of improvements. The innovation is to provide a management solution to the ageing demographics across Europe by creating an evidence-based approach targeting cognitive and motor learning parameters for elder adults to improve their overall motor function using an ecological dancelike sequence learning task. We propose a three-stage approach to investigate and provide a viable solution. In the first stage, we will address historical and current theoretical issues with the quantification of motor learning development in elder adults. Addressing topics such as dynamical systems and the aggregation of performance analyses in the face of a large range of baseline physical differences in the elderly will shed new light in a theoretically driven perspective. In the second stage, we will create an integrated neurocognitive model of motor learning representation for the elderly using advanced supervised machine learning with real EEG and behavioural data. Lastly, we will create and pilot an individualised intervention based on the model in the second stage, that targets cognitive control using meditation, and physical parameters with progressive chunk scaling approaches to drive greater learning outcomes in a shorter timeframe for the elderly. The results from this project have the potential to change health management policies and future applications of advanced brain computer interfaces.
PEDAL FOR PRIMARY AND AUXILIARY CONTROLS

The invention relates to a pedal (1; 21) for primary and auxiliary electric controls comprising a floor fixing element (2; 22), a pedal element (4; 24) coupled with said floor fixing element (2; 22) in such a way to be possible to push the same pedal element toward the floor from a lifted position, means opposing against said pushing action, button means (7, 8; 27, 28), that can be pushed by the foot, to carry out the wished controls, and/or lateral means (9, 10; 29, 30), movable by lateral motion of the foot, and stop (6; 26) means for the pushing of the pedal element (4; 24).