SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Innovative cultural and creative clusters in the MED area

Cultural and creative industries (CCIs) represent highly innovative SMEs.For participating regions CCIs is a strategic sector of development as underlined in their RIS3s,but this potential is hampered by a gap of information on CCI local environment,innovation and market barriers and a lack of tailored support to stimulate innovation,internationalization and cross fertilization.ChIMERA main objective is to improve innovation capacities of CCI public and private actors through strengthened cooperation among companies, research bodies,public authorities and civil society.Thanks to ChIMERA,CCIs key actors will improve their innovation capacities, regions will strengthen innovative CCIs clusters,cooperating in a transnational network, clusters members will benefit of tailored services to meet innovation needs and regions will concretely pursue innovation strategies on CCIs.
Main outputs: 10 Strategic action plans,1 transnational operational to develop innovative CCIs clusters; 10 clusters business plans; 12 internationalization services to fill CCIs innovation gaps;20 financial tools; 10 innovation projects.Regional and local authorities, research&education centres, SMEs, CCIs clusters, investors, civil society are outputs end users. 
ChIMERA follows an integrated approach to support RIS3s and development of CCIs Clusters. Transnational approach is necessary to find synergies among regional CCIs specializations and to promote internationalization of CCIs innovative clusters.
Tourist promotion of reclamation and rural building itineraries in the cross-border area

The project includes initiatives aimed at the tourist enhancement of reclaimed territories in Eastern Veneto and in the Slovenian area of Ajdovščina, with the aim of increasing tourist flows also in the low tourist season. The project intends to foster a thematic tourism linked to the history of reclamation in its different historical, architectural and environmental aspects, in an environment-friendly perspective. It is the response to the need to promote and enhance the valuable construction work that was done to reclaim the rural area in parts of the Venetian and Slovenian territories, bearing witness to the evolution of this area, thus encouraging thematic tourism and cycling itineraries and river activities. Research and cataloguing activities will be followed by the organization of workshops on land reclamation; an Atlas of the reclaimed area in the cross-border territory will be drawn up with the identification of a common thematic itinerary, which includes a guided tour in the reclamation district of the Consortium. The development of tourist attractions leads to an enhancement of the reclamation construction works and of the rural landscape, as well as of the cycling routes developed along the river of which the Consortium is in charge. The project aims at diversifying and increasing, also in the low tourist season, the tourism offer of the Venetian hinterland, located between the Livenza and the Tagliamento rivers, as well as of the Slovenian area of Ajdovščina, whose significance, while potentially very high, remains today at the margins of the important tourist flows that characterize instead the coast of the province of Venice.
THERMAL TRANSPIRATION GENERATOR SYSTEM

A thermal transpiration generator system includes a parabolic dish, a secondary reflector receiving solar energy from the parabolic dish, and a carrier tube directing solar energy from the secondary reflector to a thermal transpiration generator. The thermal transpiration generator includes a sealed vacuum container, a horizontally disposed rotatable shaft within the sealed vacuum container, bearings supporting the rotatable shaft, a first set of vanes secured to the rotatable shaft for rotation therewith, a second set of vanes secured to the rotatable shaft for rotation therewith, a high rpm flywheel secured to the shaft between the first and second sets of vanes, an electric generator operatively coupled to the rotatable shaft to be driven by rotation of the rotatable shaft, and a solar energy distribution system for receiving solar energy from the carrier tube and directing light to each of the first and second sets of vanes.
Smartheart, a 3d in vitro assay for improved assessment of cardiac drug efficacy and toxicity

Currently, animal models are still widely used in the pre-clinical stage of drug development to mimic human diseases or predict the human body’s response to candidate drugs. However, their use should be minimized as much as possible due to ethical issues and since only 9.6% of drugs entering phase I of clinical trials end up being commercialized.  Therefore, the goal of this action is to develop a novel proprietary 3D in vitro cardiac assay.  The SmartHeart will retrieve several of the most important read-outs commonly assessed to study the impact of drugs at the cardiac level in the pre-clinical phase. The all in one assay will be based on a microstructured gel where cardiac cells, as cardiomyocytes derived from induced pluripotent stem cells will be cultured. The SmartHeart will answer to the shortcomings of academic and commercial available in vitro assays, by enabling the qualitative and quantitative measurement of several parameters, as contractility and Calcium transients. Simultaneously, the assay will enable sub-cellular structure observation via high-resolution imaging techniques. Furthermore, the 3D nature of the assay will contribute to the efficient maturation of the induced CMs, which is still a limiting factor when not using cardiac human cells, but rather induced CMs, in in vitro assays. The ultimate aim of the project is to make this device available to screening platforms, e.g. Pharma or CROs. The technology will be implemented in multiwell plates compatible with the standards of HTS/HCS and will be available to early-users, from whom feedback will be acquired, enabling to fine tune the specifications of the final device. This project will meet the best of the ER competences in physics, with the expertise of 4Dcell in 3Dcell culture systems. With this project, the ER will reach a level of maturity on several technological, managerial and industrial aspects providing her a new career angle and put her a step closer to act as a leader in research.
Comparative studies on radioluminescent and thermoluminescent spectra of LiF:Mg,Cu,P and LiF:Mg,Cu,Si

The influence of various annealing treatments on radioluminescent (RL) and thermoluminescent (TL) spectra of LiF:Mg,Cu,Si and LiF:Mg,Cu,P was investigated. The TL and RL emission bands for LiF:Mg,Cu,P are not the same; however, the emission band peaking at ∼383 nm is predominant in the TL and RL emission for LiF:Mg,Cu,Si. With the increase in annealing temperatures in the range of 240-300°C, for LiF:Mg,Cu,P, the intensity of TL decreases much more rapidly than that of RL. For LiF:Mg,Cu,Si, the area ratios of the two bands of RL and TL remain constant within experimental errors. It suggests that there is a significant decrease in the concentration of recombination centres in LiF:Mg,Cu,P after the annealing, in addition to the decrease in trapping centres, the recombination centres for main TL emission and RL emission in LiF:Mg,Cu,Si are the same, and the recombination centres for TL emission and RL emission in LiF:Mg,Cu,P are not the same. P is a more effective dopant than Si.
Sostegno alla bioinnovazione per gli imprenditori in tutte le regioni NWE

BioBase4SME si concentra sull'economia biobased emergente. Questa economia è molto multisettoriale, in quanto colpisce almeno 19 settori tradizionali. Questa multidisciplinarità lo rende un punto di forza per l'innovazione, ma allo stesso tempo difficile portare le innovazioni sul mercato, come il processo produttivo, le catene del valore e talvolta anche i prodotti sono attualmente inesistenti. BioBase4SME consentirà flussi di conoscenza tra servizi di supporto professionale e imprenditori. Formazione e mentoring 1-to-1 saranno forniti per quanto riguarda le questioni che sono essenziali per portare un'innovazione con successo sul mercato, ma mostrano di essere persistenti colli di bottiglia che sradicare le innovazioni promettenti. Il sostegno si concentrerà su (i) fornire una prova di concetto industriale e (ii) sviluppare un piano aziendale realistico che includa l'analisi di mercato e il completamento della nuova catena del valore. Entrambe le questioni sono primordiali per convincere qualsiasi tipo di investitore. BioBase4SME si basa sulle competenze e gli apprendimenti raccolti in progetti precedenti, in particolare il successo del progetto Interreg IVB Bio Base NWE. Ci aspettiamo di avvicinare almeno 20 promettenti innovazioni al mercato, con conseguente nuovi investimenti e creazione di posti di lavoro, e fornire formazione a circa 200 imprenditori attivi nell'economia biobased, rafforzando così la loro capacità di innovazione. Altri risultati principali sono una rete forte e interregionale per guidare gli imprenditori verso un'innovazione di successo, un migliore sostegno regionale alla bioeconomia in termini di innovazione e clima di investimento, quadro giuridico e approvazione pubblica. La disparità tra la capacità di innovazione biologica in Irlanda rispetto al resto della NWE sarà diminuita. La partnership BioBase4SME seguirà la strategia, il suo successo e le lezioni apprese. Queste informazioni saranno raccolte in un report completo e materiale promozionale che sarà disponibile su richiesta attraverso i partner e sui social media, anche dopo la fine del progetto.
Interacting decentralized transactional and ledger architecture for mutual credit

The objective of INTERLACE is to use the Abstract State Interaction Machines framework (CoreASIM) open source output of the FP7 FET project BIOMICS to develop a decentralized transactional and ledger architecture demonstrator for B2B mutual credit. INTERLACE will add to the work already started by its coordinator, Sardex s.r.l., to develop this architecture. SARDEX will use the Open Transaction protocol (OTX) as an intermediate solution between fully centralized and distributed architectures. OTX involves a pool of Auditor nodes to validate the transactions executed by each Notary node. In INTERLACE there will be only one central Notary, as a first step from the current centralized server towards a more distributed architecture. The persistence layer will be implemented as a private blockchain stored on the central server to create a sparse 160-bit address space implemented as a binary hash tree. This approach achieves continuity with the existing solution while also enabling scalability to multiple circuits (multiple Notaries) under the same mathematical and computational framework. SARDEX has been operating successfully an electronic, B2B, zero-interest mutual credit system on the island of Sardinia since 2009. The Sardex system (also known as Circuito di Credito Commerciale) enables local economic actors (SMEs in particular) to trade with each other in a trustful and circular fashion with a unique digital trade credit unit. It does this by monetizing the spare capacity of the local economy in the form of mutual, and taxable, credit between participating companies, at zero interest, on a strong basis of trust, solidarity, and local cultural identity. Therefore, INTERLACE will address very effectively the Workprogramme objective to generate socio-economic impact from EU-funded research. INTERLACE is uniquely positioned to integrate the very advanced results of BIOMICS directly in a deeply innovative, transformative, and successful fintech platform for B2B trade.
Innovation denmark 2019

The objectives of the Innovation Denmark 2019 project are to: 
•	Provide Key Account Management (KAM) services to Danish businesses, which have been awarded grants under the SME Instrument, Future Emerging Technologies or Fast Track to Innovation programmes
•	Provide Enhancing Innovation Management Capacity (EIMC) services to SMEs in 2019. Companies will be assessed via the Innovation Health Check tools or other approved tools and depending on results, referred on to relevant organisations in the Danish and European innovation eco-system.
In total, under both categories 100 service packages will be carried out. The figure is based on an average of 46 KAM packages coming through EIC programmes, and 44 EIMC cases carried out. If a larger number of grants from EIC are given to Danish participants, the packages will be adjusted accordingly.
The figures are based on the experience of the Danish consortium since 2014, which has seen a high and increasing number of cases coming through via the SME Instrument, due to the success Danish companies have in the programme.
Pre-school predictors of early arithmetic skills: a two year longitudinal study

The purpose of this thesis was to examine longitudinal predictors of children’s early arithmetic abilities with a particular focus on the relation to the approximate number system (ANS), language and numeracy skills as well as background measures of cognitive abilities. This longitudinal study assessed children five times over a 25-month period beginning in nursery classes and continuing to the end of Year One (the first complete year of formal schooling). The thesis investigated the concurrent and longitudinal predictive importance of ANS, numeracy, language and cognitive abilities in children’s arithmetic development using structural equation modelling. Path models found different concurrent predictors of arithmetic at each time point and only transcoding, the ability to translate between the verbal number code and the Arabic numeral, was a consistently recurring predictor. Furthermore, children’s nonverbal intelligence and their understanding of language specific to mathematics related significantly to early arithmetic (pre-school) whereas children’s magnitude comparison skills were significantly associated with arithmetic scores in Year One. The longitudinal analysis showed that transcoding was the only unique predictor of arithmetic and neither ANS nor language and cognitive skills were significant independent contributors to the prediction of children’s arithmetic abilities 25 months later.
Advancing rechargeable-batteries through in situ techniques

Li-ion batteries (LIBs) have enabled the portable device revolution of the last two decades, and have undoubtedly had a dramatic societal impact, with rechargeable electronic devices now ubiquitous. The light Li-containing electrodes, and high working cell voltages (typically >3.5 V) make LIBs the most practical solution for many portable applications. However, when significantly larger storage capacity is demanded, such as in transportation or grid-based energy storage, the limited availability, and consequently elevated cost, of Li becomes prohibitive. This research project will investigate alternative battery technologies that use more earth-abundant ions for charge transport, namely Mg, to enable the next generation of energy storage devices. The atomic-scale mechanisms of Mg-ion insertion/extraction at electrode-electrolyte interfaces and how these interfaces evolve during charging/discharging will be investigated. Complementary in situ techniques will be used to investigate the evolution of electrode structure and chemical state using carefully designed model electrodes. The study of scaled-up electrodes integrated into complete batteries will extend this understanding to more realistic battery cycling conditions. This will provide important insights to help overcome the limitations of the materials currently used in Mg-ion batteries (MIBs). The ground-breaking nature of this proposal lies in the level of fundamental understanding we aspire to achieve based on in situ metrology. We thereby envision the rational design and optimisation of the next generation of rechargeable batteries, guided by more than just the existing empirical approach.
Conducting industrial research and development work at SZPEC Piotr Szwajkowski, enabling the development of a unique recipe related to the quality of light artificial aggregates obtained using fine granite waste and the disposal of municipal sewage sludge.

Reference number of the aid programme: SA.41471(2015/X) Purpose of public aid: Article 25 of EC Regulation No 651/2014 of 17 June 2014 declaring certain types of aid compatible with the internal market in the application of Articles 107 and 108 of the Treaty (OJ L. I'm sorry. EU L 187/1 of 26.06.2014). Under this project, research is planned to develop a unique recipe related to the quality of lightweight aggregates obtained using fine granite waste and the disposal of municipal sewage sludge, in order to offer it to its customers in the form of a licence. The aim of the project is to solve the problem of the development of a huge amount of fine granite waste that has arisen during production processes of granite stone processing in the masonry &ndash; it’s called granite abrasive. The formula will allow the use of this waste in the production process. Important is the planned large development (up to 60 %) of the recycled municipal sewage sludge in the composition of light artificial aggregate recipes. The final product resulting from research will be innovative internationally. In terms of product innovation, it is planned primarily to achieve higher mechanical strength compared to other lightweight aggregates (which, with the above aggregates used for the production of concrete construction prefabricated prefabricated materials, allows to obtain a higher strength class of these products) and to achieve a higher thermal insulation coefficient. The objectives of the project will be achieved by carrying out industrial research (stage I and II) and development work (stage III).
PACMAn - Promoting attractiveness, competitiveness and internationalisation of Agro-food Clusters of the Med Area

PACMAn aims at stimulating the innovative&dynamic capacities of the agrofood sector in MED regions able to promote its attractiveness & competitiveness at transnational level.Through collaboration between transnational economic development actors&public authorities engaged in growth & innovation issues, PACMAn will focus on key factors of agro-food clusters in MED areas, in light of the latest economic changes & trends, and will implement pilot actions which, coupled with a shared joint analysis & networking, will provide new horizontal solutions to the cluster criticalities & inputs for elaboration of integrated policies, territorial marketing & a sustainable innovative model to support agrofood sector expansion at international level
Identification of Specific Determinants of Human APOBEC3F, APOBEC3C, and APOBEC3DE and African Green Monkey APOBEC3F That Interact with HIV-1 Vif

ABSTRACT Human APOBEC3F (hA3F) and human APOBEC3G (hA3G) are potent anti-human immunodeficiency virus (anti-HIV) host factors that suppress viral replication by hypermutating the viral genome, inhibiting reverse transcription, and hindering integration. To overcome hA3F and hA3G, HIV-1 encodes Vif, which binds and targets these host proteins for proteasomal degradation. Previously, we reported that the hA3F-Vif interactions that lead to hA3F degradation are located in the region comprising amino acids 283 to 300. We have now performed mutational analysis of this region and found that the 289 EFLARH 294 amino acids contribute to hA3F-Vif binding and are critical for A3F's sensitivity to Vif. Mutants in which E289 is mutated significantly increase hA3F's ability to inhibit viral infectivity in the presence of Vif, and coimmunoprecipitation assays show that binding of Vif to the E289K mutant is decreased. We examined the role of the EFLARH sequence in other A3 proteins, including human A3C (hA3C), human A3DE (hA3DE), African green monkey A3F (agmA3F), and rhesus macaque A3F (rhA3F). hA3C, hA3DE, and agmA3F were all susceptible to degradation induced by HIV-1 Vif, while rhA3F was not. Mutagenesis of the glutamate in the EFLARH sites of hA3C, hA3DE, and agmA3F decreases the susceptibilities of these proteins to Vif-induced degradation. Together, these results indicate that the EFLARH region in hA3F, hA3C, hA3DE, and agmA3F interacts with HIV-1 Vif and that this interaction plays a role in the Vif-mediated proteasomal degradation of these A3 proteins. These studies identify a conserved region in 3 of 7 human A3 proteins that is critical for degradation mediated by HIV-1 Vif and provide structural insights into the hA3F-Vif interactions that could facilitate the development of a novel class of anti-HIV agents.
Female gender is associated with long COVID syndrome: a prospective cohort study

ObjectiveWe explored the association between female gender and long COVID syndrome, defined as persistence of physical and/or psychological symptoms for more than 4 weeks after recovery from acute COVID-19 disease. The secondary aim was to identify predictors of long COVID syndrome by multivariable logistic regression analysis.MethodsThis was a single-centre prospective cohort study conducted at San Paolo Hospital in Milan, Italy. We enrolled adult patients who were evaluated at the post-COVID outpatient service of our Infectious Diseases Unit between 15 April 2020 and 15 December 2020. Participants were individuals who had clinically recovered from COVID-19 and in whom virological clearance had occurred. Previous infection by SARS-CoV-2 was microbiologically documented by positivity using a reverse-transcriptase polymerase chain reaction (RT-PCR) assay of nasopharyngeal swab. All enrolled patients underwent blood tests and a comprehensive medical examination at follow-up. Individuals were interviewed about resolved and persisting symptoms and were asked to fill in two questionnaires to allow assessment of the Hospital Anxiety and Depression symptoms (HADS) score and of the Impact of Event Scale–Revised (IES-R) score.ResultsA total of 377 patients were enrolled in the study. The median time from symtpom onset to virological clerance was 44 (37–53) days. A diagnosis of long COVID syndrome was made in 260/377 (69%) patients. The most common reported symptoms were fatigue (149/377, 39.5%), exertional dyspnoea (109/377, 28.9%), musculoskeletal pain (80/377, 21.2%) and "brain fog" (76/377, 20.2%). Anxiety symptoms were ascertained in 71/377 (18.8%) individuals, whereas 40/377 (10.6%) patients presented symptoms of depression. Post-traumatic stress disorder (defined by a pathological IES-R score) was diagnosed in one-third of patients (85/275, 31%). Female gender was independently associated with long COVID syndrome at multivariable analysis (AOR 3.3 vs. males, 95% CI 1.8–6.2, p < 0.0001). Advanced age (adjusted (A)OR 1.03 for 10 years older, 95% CI 1.01–1.05, p 0.01) and active smoking (AOR 0.19 for former smokers vs. active smokers, 95% CI 0.06–0.62, p 0.002) were also associated with a higher risk of long COVID, while no association was found between severity of disease and long COVID (AOR 0.67 for continuous positive airway pressure (CPAP)/non-invasive mechanical ventilation (NIMV)/orotracheal intubation (OTI) vs. no 02 therapy, 95% CI 0.29–1.55, p 0.85).DiscussionFactors that were found to be associated with a higher risk of developing "long COVID" syndrome were female gender, older age and active smoking, but not severity of the acute disease. Individuals affected by SARS-CoV-2 infection with the aforementioned features should be early identified and involved in follow-up programmes.
CAFÉ MAURO S.P.A. — INTERNATIONAL COFFEE

MAURO DEMEIO S.P.A. — THE TWO TARGET MARKETS WE WATCH ARE CHILE AND MOROCCO. THE CAFFÃO MAURO HAS UNIQUE PRESENCE ON THE FOREIGN MARKET, OPERATING IN OVER 40 COUNTRIES IN ALL DISTRIBUTION CHANNELS AND EXTERNAL TURNOVER REACHES ABOUT 40 % OF THE TOTAL GL.