SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Parp1 activation in mouse embryonic fibroblasts promotes Pol β-dependent cellular hypersensitivity to alkylation damage

Alkylating agents induce cell death in wild-type (WT) mouse embryonic fibroblasts (MEFs) by multiple mechanisms, including apoptosis, autophagy and necrosis. DNA polymerase beta (Pol beta) knockout (KO) MEFs are hypersensitive to the cytotoxic effect of alkylating agents, as compared to WT MEFs. To test the hypothesis that Parp1 is preferentially activated by methyl methanesulfonate (MMS) exposure of Pol beta KO MEFs, we have examined the relationship between Pol beta expression, Parp1 activation and cell survival following MMS exposure in a series of WT and Pol beta deficient MEF cell lines. Consistent with our hypothesis, we observed elevated Parp1 activation in Pol beta KO MEFs as compared to matched WT MEFs. Both the MMS-induced activation of Parp1 and the MMS-induced cytotoxicity of Pol beta KO MEFs are attenuated by pre-treatment with the Parp1/Parp2 inhibitor PJ34. Further, elevated Parp1 activation is observed following knockdown (KD) of endogenous Pol beta, as compared to WT cells. Pol beta KD MEFs are hypersensitive to MMS and both the MMS-induced hypersensitivity and Parp1 activation is prevented by pre-treatment with PJ34. In addition, the MMS-induced cellular sensitivity of Pol beta KO MEFs is reversed when Parp1 is also deleted (Pol beta/Parp1 double KO MEFs) and we observe no MMS sensitivity differential between Pol beta/Parp1 double KO MEFs and those that express recombinant mouse Pol beta. These studies suggest that Parp1 may function as a sensor of BER to initiate cell death when BER is aborted or fails. Parp1 may therefore function in BER as a tumor suppressor by initiating cell death and preventing the accumulation of cells with chromosomal damage due to a BER defect.
Unterstützung von KMU, die Omnibusdienste betreiben, um die wirtschaftlichen Auswirkungen der COVID-19-Pandemie zu überwinden

Unterstützung von KMU, die Omnibusdienste betreiben, um die wirtschaftlichen Auswirkungen der COVID-19-Pandemie zu überwinden
Identifying climate-related hydrologic regime change in mountainous, cold-region watersheds

The watershed response to climate warming in cold regions is a critical area of water resources research because slight changes in temperature can trigger abrupt changes in hydrologic regimes. A regime shift occurs when the cumulative effect of small perturbations causes an abrupt change in system behavior. As mountainous cold regions warm, potential regime shifts include the loss of snow and glaciers, permafrost thaw, and transitioning from snow-dominated to rainfall-dominated streamflow patterns. Cold regions occupy over half of the land area in the northern hemisphere, and encompass a broad range of physiographic features and climates; this research into regime change focuses on a subset of cold regions situated in mountainous terrain at mid- and high-latitudes where streamflow is dominated by seasonal snow and glacier meltwater. The science questions guiding this dissertation research explore the hydrologic regime changes that may occur as cold region landscapes continue to warm. To facilitate this research, and to address the absence of a parsimonious water balance model with integrated glacier dynamics and permafrost features, an established USGS water balance model was substantially enhanced with representations of multiple cold region processes. Modeling of hydroclimatic interactions spanning the time period 1950 to 2100 was performed in two different cold-region landscapes: the snow-dominated Rio Grande Headwaters (RGH) in the Colorado Rocky Mountains and the heavily glacierized Copper River watershed in Southcentral Alaska. The mid-latitude RGH reveals little streamflow sensitivity to historical changes in climate, but it does exhibit vulnerability to projected future climate change; by the end of this century, the RGH may no longer possess the characteristics of a snow-dominated watershed that define it today. In the Copper River, discharge is projected to surge by almost 50% by the end of this century as precipitation increases and water is released from perennial storage in snow and ice; however, as glacier mass is exhausted, the inevitable decline of glacier contributions to streamflow will be evident in some tributaries as early as the 2050s.
SOLID-STATE POST-CONDENSATION PROCESS FOR INCREASING THE MOLECULAR WEIGHT OF A POLYAMIDE

The invention relates to a process for increasing the molecular weight of a polyamide via solid-state post-condensation by exposing the polyamide in the solid-state at elevated temperature to an inert gas atmosphere, that comprises a step a wherein the gas atmosphere to which the polyamide is exposed has a dew temperature Tdew-1, followed by a step b wherein the gas atmosphere to which the polyamide is exposed has a dew temperature Tdew-2, whereby Tdew-1 is higher than Tdew-2. The effect is that a high molecular weight polyamide can be obtained in a shorter production time.
RAIL CLAMP

A clamp (1) for a rail (2), said rail (2) comprising a web (7) extending between a rail head (8) and a rail base (6). The clamp (1) comprises: a frame (3) which has a first longitudinal axis (11) and on which elements are mounted successively along the first axis (11); and a control unit (33) suitable for controlling the at least one actuator (5) such as to apply a straightening torque to the rail (2), in a plane parallel to the first and third axes (11, 13), between the actuator (5) acting on the rail and the engaged hooking device (18).
APPARATUS AND METHODS FOR PLACING AN ADDITIVE FLUID INTO A REFRIGERANT CIRCUIT

A supply canister (28) is partially filled with a refrigerant circuit additive liquid (10) and is partially evacuated. Additive liquid from the canister (28) may be placed into the refrigerant circuit (23) of an air conditioning system by (1) connecting the canister (28) to the circuit after it has been emptied and a vacuum pressure created therein, (2) connecting the canister (28) to the refrigerant circuit suction line (12a) during system operation, or (3) connecting the canister (28) to the suction line (12a) with the system off, to thereby force refrigerant from the circuit (12) into the canister (28), and then starting the system to cause the vacuum pressure in the suction line (12a) to draw the contents of the canister into the refrigerant circuit.
Study on PIDNN-Based Flow Control in Layered Water Injection Technology in Oilfield

This paper takes the layered water injection technology in oil production engineering as research object. This technology is characterized by strong nonlinearity, strong interlayer interference, time variation and complex model. Focusing on these characteristics, this paper proposes a novel control strategy based on PID-NN algorithm to satisfy the requirements of layered water injection technology. Many performance indexes of the controller are optimized, including model establishment of nonlinear controlled object, multi-parameter decoupling, controller acceleration and precision improvement. The simulation and experiment show that compared with traditional controller based on PID and controller based on BP neural network, the optimized controller has stronger robustness, faster response and better flow control, so it has an advantage over traditional controllers of dealing with discrete events and multi-variable decoupling problems.
Travel control system of construction machine

To reduce load on the operator and to establish traveling stability in the steering operation of a construction machine that has a pair of right and left traveling devices, and an engine as a driving power to the right and left traveling devices, a controller is provided which is responsive to a switch for traveling to drive or stop both a right and a left traveling devices. A switch for steering causes the controller to change the direction of travel of the construction machine, and the controller also acts to reduce the engine speed in accordance with the operation amount of the switch for steering.
Does delaying judgments of learning really improve the efficacy of study decisions? Not so much.

A widely held assumption in metamemory is that better, more accurate metamemory monitoring leads to better, more efficacious restudy decisions, reflected in better memory performance--we refer to this causal chain as the restudy selectivity hypothesis. In 3 sets of experiments, we tested this hypothesis by factorially manipulating metamemory monitoring accuracy and self-regulation of study. To manipulate monitoring accuracy, we compared judgments of learning (JOLs) made contemporaneously with a delayed retrieval attempt to JOLs either made at a delay without attempting retrieval or made immediately after study; in previous studies, delayed retrieval-based JOLs have robustly predicted recall with greater relative accuracy than have the other JOL types. To manipulate self-regulation of study, in Experiments 1A-1C and 2A-2C, we compared conditions in which participants' restudy selections were honored with conditions in which they were completely or randomly dishonored; in Experiments 3A-3C, we randomly honored or dishonored half of the restudy selections and half of the nonselections. Results revealed that the benefit of delayed, retrieval-based JOLs for final memory performance was due largely to the selection of more items for restudy rather than to better discriminations between items that would benefit more versus less from restudy. In most cases, gains in recall due to greater self-regulation of study did not increase with better monitoring accuracy; when they did, the effect was extremely small. The surprising conclusion was that restudy decisions were not very much more efficacious under conditions that yield greater monitoring accuracy than under those that do not.
MARINE ROSARY JOHN

REQUEST FOR FACILITATION REFERRED TO IN THE PUBLIC NOTICE OF SMALL ENTITEUR GRANTS TO SMES SUSPENDED OR WITH A SERIOUS FALL IN TURNOVER
Promoting Zero Waste

The Zerowaste Pro aims to capitalize the results and outputs along with the know-how and expertise acquired in the Med and other EU projects implemented by the partnership with the aim of promoting sustainable low-cost waste management strategies in the MED region and IPA countries with an emphasis on waste prevention, reuse, recycling and composting and to establish synergies between the participating countries and their relative stakeholders so as to integrate the highest level of cooperation and integration. The focus on low cost-sustainable waste management options is of particular importance in this time of economic recession. This will be done through the following actions: 1) International conferences in each of the eight participating countries which will disseminate the existing tools and results and further develop them to include and integrate them within existing practices and experiences of the new participating stakeholders. 2) Training activities through workshops and training of trainers will be developed and carried out aimed at transmitting the developed tools to the local decision makers, including both public and private stakeholders. 3) The project will have a very strong communication strategy which will include guides, information packages, info days, web based information platforms, printed material, presentation in schools including an environmental education pack, press releases and technical articles. 4) A pilot application of a green island will be implemented in Bedekovčina. 5) An information package aimed at SMEs and industrial areas will be developed to address how low cost sustainable zero waste management initiatives can be realized by this sector. The project will result in increased awareness and training of key actors in the waste management sector in the participating regions. The extended access to a range of tools disseminated through the project and an increase in low-cost zero waste strategies.
Ovarian cancer today and tomorrow: A global assessment by world region and Human Development Index using <scp>GLOBOCAN</scp> 2020

Abstract Ovarian cancer remains to have relatively poor prognosis particularly in low‐resourced settings. It is therefore important to continually examine the burden of ovarian cancer to identify areas of disparities. Our study aims to provide an overview of the global burden of ovarian cancer using the GLOBOCAN 2020 estimates by country, world region, and Human Development Index (HDI) levels, as well as the predicted future burden by the year 2040 by HDI. Age‐standardized incidence and mortality rates for ovarian cancer in 185 countries were calculated by country, world region, and for the four‐tier HDI. The number of new cases and deaths were projected for the year 2040 based on demographic projections by HDI category. Approximately 314 000 new ovarian cancer cases and 207 000 deaths occurred in 2020. There were marked geographic variations in incidence rates, with the highest rates observed in European countries with very high HDI and low rates were found in African countries within the lowest HDI group. Comparable mortality rates were observed across the four‐tier HDI. Relative to 2020 estimates, our projection for 2040 indicates approximately 96% and 100% increase in new ovarian cancer cases and deaths, respectively, among low HDI countries compared to 19% and 28% in very high HDI countries. Our study highlights the disproportionate current and future burden of ovarian cancer in countries with lower HDI levels, calling for global action to reduce the burden and inequality of ovarian cancer in access to quality cancer care and treatment.
Music expression with a robot manipulator used as a bidirectional tangible interface

The availability of haptic interfaces in music content processing offers interesting possibilities of performer-instrument interaction for musical expression. These new musical instruments can precisely modulate the haptic feedback, and map it to a sonic output, thus offering new artistic content creation possibilities. With this article, we investigate the use of a robotic arm as a bidirectional tangible interface for musical expression, actively modifying the compliant control strategy to create a bind between gestural input and music output. The user can define recursive modulations of music parameters by grasping and gradually refining periodic movements on a gravity-compensated robot manipulator. The robot learns on-line the new desired trajectory, increasing its stiffness as the modulation refinement proceeds. This article reports early results of an artistic performance that has been carried out with the collaboration of a musician, who played with the robot as part of his live stage setup.
Implementación de un plan de coaching para disminuir la rotación laboral de los colaboradores de la empresa constructora LCM Ingenieros S.A.C. en la ciudad de Lima – año 2015

The research main objective was coaching plan that allows reducing labor turnover and
commitment employees of the construction company Ingenieros SAC LCM in the city
of Lima - 2015.
The research problem: Implementing a coaching plan will reduce labor turnover of
employees of the company LCM Ingenieros SAC in the city of Lima - 2015? The
hypothesis is: The Coaching Plan will significantly reduce labor turnover in employees
of the company LCM Ingenieros SAC in Lima - 2015. Its general objectives: Develop a
coaching plan that allows reducing labor turnover in employees of the construction
company LCM Ingenieros SAC in Lima - 2015.
The research is applied. The research was descriptive design contracts. The sampling
frame comprises the payroll of the construction workers' school sanitation Markham
LCM SAC company engineers. Sample: worked with the entire population.
The conclusion is: According to the research we have done we conclude that every
organization must provide coaching program. Since it is a tool that allows employees to
change their outlook and increased commitment and responsibility which translates into
better results for the organization.
Damping device to solve the pantograph-line capture problems, especially for the eu high-speed railways lines

Officina Fratelli Bertolotti S.p.A. was founded in 1901 as a small workshop that was working as blacksmith. From 1920 it specialised in special iron carpentry and in the post-war period it becomes a modern industry thanks to the acquisition of customers in the industry ""Electricity transmission"". Today the company brand is linked to that of the most important Electrical and Transport companies in various countries. The proposed innovation was started in order to respond to the emerging needs of the railway sector for the high-speed trains infrastructure. The goodness of the electric power uptake by the thread of the airline has been a problem since the abandonment of the ""third rail"", but the increase in speed and power demands made it even more difficult to ensure continuous contact between catenary and crawling, with the consequent formation of electrical arcing which can damage fixed installation, pantograph and electrical systems of the train. The ability to maintain a continuous and fluid contact between these two elements is one of the main factors that limit the allowable speed of trains. The most direct solution, that is the stringing of conductors, involves considerable problems related to the substitution of the infrastructure: high costs and rail traffic interruption. Our innovation exploits the non-linear kineto-dynamic made by the specific construction, it is mechanically simple, does not use materials sensitive to temperatures, nor dissipation by Joule effect, works for small and large oscillations, does not use fluids that may be dispersed in the environment, and can be inspected visually. Furthermore, it is much less expensive than the replacement of the conductors and of support structures, allowing to save 90% of replacement costs. From the esploitation of SPEED-EU we expect to create 15 new jobs, enter into the rail sector and increase revenues of €56 million in a 4-years commercialization period.
The risk factors and preventive measures for poor maternal-infant outcomes of pregnancy-induced hypertensive disorders

Objective To analyze the risk factors for poor maternal-infant outcomes of hypertensive disorders in pregnancy and to explore the effective preventive measures. Methods Totally 186patients with hypertensive disorders in pregnancy admitted to Maternal and Child Health Hospital of Baoding City from May 2012to April 2013were enrolled in this study.The impact of pregnant women's baseline information,pregnancy condition and disease status on maternal and neonatal health outcomes were analyzed. Results Overall,116cases had a favorable outcome,while 70had a poor outcome.The risk factors for poor maternal-infant outcomes were as follows:age≥35years,low education level,abnormal body mass index,absence of folic acid supplement during pregnancy,absence of regular prenatal care checkup,and the types of diseases and complications. Conclusions The maternal-infant outcomes of hypertensive disorders in pregnancy are associated with many factors,and hence,clinicians should be aware of the risk factors and take effective preventive measures to improve maternal-infant outcomes of hypertensive disorders in pregnancy.
Comprehensive review on ethanobotanical uses, phytochemistry and pharmacological properties of Melia azedarach Linn

Medicinal plants, since times immemorial, have been used in virtually all cultures for therapeutic purposes . The widespread use of herbal remed ies and healthcare preparations obtained from commonly used traditional herbs and medicinal plants have been traced to the occurrence of natural products with medicinal properties. In the present review, an attempt has been made to collect the botanical, phytochemical, ethnomedicinal, pharmacological and toxicological information on Melia azedarach L. which is used traditionally as an anthelmintic, diuretic, emmenagouge, expectorant, vermifuge, used in piles, used as astringent, used in hysteria, leprosy, and in scrofula. Medicinally it has been shown to possess various p harmacological activities like anti fungal, anti - malarial, antibacterial, hepatoprotective, anti - oxidant, anti - fertility, anthelmintic, antipyretic and cytotoxic activities. The available literature on the M. azedarach L. revealed that this plant contains many phyto chemical constituents including alkaloids, terpenoids, saponins, glycosides, phenolic compounds, flavonoids and rutins. The aim of this article is to review those medicinal and pharmacological properties of M. azedarach which have been or still are being learned. The present review is therefore, an effort to give a detailed survey of the literature on its traditional, phytochemical and pharmacological properties.
Overexpression of CXCR4 on circulating B cells in patients with active systemic lupus erythematosus.

To evaluate the roles of circulating B cells in the pathogenic process of systemic lupus erythematosus (SLE) by measuring the expression of chemokines and their receptors.Peripheral-blood mononuclear cells were obtained from 17 active, 21 inactive SLE patients, and 13 healthy controls. The expression of CXCR4, CXCR5, and CCR7 on CD19+ B cells was determined by flow cytometry, serum concentration of CXCL12 was measured by enzyme-linked immunosorbent assay, and the chemotactic responsiveness of B cells toward CXCL12 was evaluated. B or plasma cells expressing CXCR4 in renal biopsy specimens were detected using immnofluorescent staining.Flow cytometric analysis revealed that expression level of CXCR4 on circulating B cells was significantly higher in patients with active disease than in those with inactive disease or controls. Serum CXCL12 concentration was not different between these groups. In addition, the migratory ability of B cells toward CXCL12 was enhanced in active SLE patients. Finally, CXCR4-expressing B cells were more frequently observed in the renal biopsy specimens of lupus nephritis.Up-regulated CXCR4 expression on circulating B cells in active SLE may enhance their chemotactic response toward CXCL12, which may promote infiltration of these cells into inflamed renal tissue and contribute to the development of SLE.