SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
64Cu-DOTA-trastuzumab PET imaging and HER2 specificity of brain metastases in HER2-positive breast cancer patients

The purpose of this study was to determine whether brain metastases from HER2-positive breast cancer could be detected noninvasively using positron emission tomography (PET) with (64)Cu-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA)-trastuzumab.PET was performed on five patients with brain metastases from HER2-positive breast cancer, at 24 or 48 h after the injection of approximately 130 MBq of the probe (64)Cu-DOTA-trastuzumab. Radioactivity in metastatic brain tumors was evaluated based on PET images in five patients. Autoradiography, immunohistochemistry (IHC), and liquid chromatography-tandem mass spectrometry (LC-MS/MS) analysis were performed in one surgical case to confirm HER2 specificity of (64)Cu-DOTA-trastuzumab.Metastatic brain lesions could be visualized by (64)Cu-DOTA-trastuzumab PET in all of five cases, which might indicated that trastuzumab passes through the blood-brain barrier (BBB). The HER2 specificity of (64)Cu-DOTA-trastuzumab was demonstrated in one patient by autoradiography, immunohistochemistry, and LC-MS/MS.Cu-DOTA-trastuzumab PET could be a potential noninvasive procedure for serial identification of metastatic brain lesions in patients with HER2-positive breast cancer.UMIN000004170.
Photonic and nanometric high-sensitivity bio-sensing

We plan to develop a radically new technology for the sensing of bio-systems and in-vivo diagnostics of biomedical conditions using hitherto unexploited tools of unconventional complex-system dynamical control and information sampling/processing. They will be founded on groundbreaking concepts and challenging experiments, with the following aims: (a) Magnetic-resonance imaging (MRI) and optically-detected magnetic-resonance (ODMR) sensing will be dramatically improved by orders of magnitude through highly selective cooling/suppression of thermal noisy background in-vivo with unprecedented spectral and spatial (subnano- or submicron-) resolution. It will be based on so far unemployed (but conceptually proven) stochastic (anti-) Zeno effects and collective-spin cooling pioneered by the partners of this very interdisciplinary consortium. (b) Development of novel probing configurations and protocols: NMR intra-molecule/intra-tissue sensing and intra-cell NV-center thermometry based on dynamical control being aimed at unravelling of hitherto invisible biochemical activity features masked by inhomogeneous broadening. (c) Advanced sensing-data processing, including high-order correlation spectroscopy – innovative strategies that seek to exploit dynamically controlled/modified noise in bio-systems as a source of previously untapped information on physiological (temporal) processes and anatomical (structural) detail. This information will be obtained by treating bio-systems as complex, noisy “environments” through novel probing/estimation procedures and compressed (sparse) imagery of the spectrally and spatially structured “environment”, but reducing drastically their complexity by dynamically controlling the relevant information encoded by key noise parameters. The overarching goal will be to substantially enrich the spatial and spectral information content and robustness of diverse medical diagnostic procedures and thereby minimize the exposure time/irradiation dosage.
Application and effects of the ESDP in Member States

The European Spatial Development Perspective (ESDP) was adopted at the Council meeting in Potsdam in May 1999. Now, seven years after the presentation of the final version of the ESDP, the effects of the ESDP at EU level and in each Member State are being assessed in order to identify the potential of the ESDP and to find best examples of its application and implementation at European, transnational, national and regional/local level. It is to be expected that ESDP also has had an impact in the new Member States as well as in the neighbouring countries, which participate in the ESPON programme. The project therefore considers the entire "ESPON-space" as the research area.
Studies on the Improvement of Roasting Condition of Sesame Seeds for Producing Seed Season and Oil

This study was carried out to find optimum roasting condition of sesame seeds for making seed season and oil treated with different temperatures and time intervals. Sesame seeds with 17~18% of moisture content were treated under fixed and changed roasting temperature conditions. The fixed temperatures are ranged from 160 to 240℃ with 20℃ intervals. The changed temperatures were treated at low(160 and 180℃) and medium(200 and 220℃) for 10 minutes, and at high(220 and 240℃) for 3 minutes. Meanwhile, roasting times were 20-30 minutes longer under low temperature condition and 3-5 minutes shorter under high temperature condition. The optimum roasting temperature and time were determined as 220℃ and 3 minutes for producing seed season, and as 220℃ and 5 minutes for sesame oil, respectively, in roasting with small quantity of sesame seeds. On the other hand, in the large scale roasting condition, those showed 240℃ and 15 minutes in for producing seed season, and 280℃ and 10 minutes and 260℃ and 15 minute for producing seed season in white-colored sesame variety and black-colored sesame variety, respectively.
METHODS AND APPARATUS FOR IN SITU SUBSTRATE TEMPERATURE MONITORING BY ELECTROMAGNETIC RADIATION EMISSION

A method in a plasma processing system of determining the temperature of a substrate. The method includes providing a substrate comprising a set of materials, wherein the substrate being configured to absorb electromagnetic radiation comprising a first set of electromagnetic frequencies, to convert the first set of electromagnetic frequencies to a set of thermal vibrations, and to transmit a second set of electromagnetic frequencies. The method also includes positioning the substrate on a substrate support structure, wherein the substrate support structure includes a chuck; flowing an etchant gas mixture into a plasma reactor of the plasma processing system; and striking the etchant gas mixture to create a plasma, wherein the plasma comprises the first set of electromagnetic frequencies. The method further includes processing the substrate with the plasma thereby generating the second set of electromagnetic frequencies; calculating a magnitude of the second set of electromagnetic frequencies; and converting the magnitude to a temperature value.
DEEP DIMMING OF AN LED-BASED ILLUMINATION DEVICE

An LED based illumination device is dimmed by controlling an average current supplied to the LED based illumination device. The currently supplied to the LED may be supplied by an LED driver that is in communication with a dimming control engine. The dimming control engine may receive an indication of a desired average current level. The dimming control engine controls the LED driver to periodically switch a current supplied to an LED of the LED based illumination device from a high state to a low state over a switching period, wherein both a duration of the switching period is adjusted and a ratio of a time in the high state to a time in the low state is adjusted as the average current supplied to the LED based illumination device transitions from a first average current level to the desired average current level.
American Muslim Investment in Civil Society

Using data from a national survey of 465 American Muslims conducted just after the 2008 election season, the authors assess whether American Muslims are invested in the practices (political discussion, especially across lines of difference) and norms (tolerance) that many theorists suggest are crucial to the maintenance of liberal democracy. The authors find that American Muslims tend to be intolerant of acts against religion. The authors’ explanation draws on intergroup relations theory, finding that post–September 11, 2001, discrimination served an educational function boosting tolerance, and disagreement in Muslim social networks tends to depress tolerance unless it is with an in-group discussion partner.
Arabia and Areal Hybridity

The present contribution proposes the existence of two ‘micro linguistic areas’ in Arabia in which features from Arabic and other Semitic languages diffused multilaterally. Some of the output varieties pose a significant challenge to phylogeny as they exhibit conflicting isoglosses connecting them equally with different lineages of Semitic. We introduce to the term ‘areal hybridity’ to explain the genetic position of languages emerging from contact situations such as these. We argue that several older varieties, such as the dialect of Ṭayyiʾ and the medieval Ḥimyaritic language described by the Arab grammarians, as well some modern varieties of southwest Arabia, such as Rāziḥī and Riǧāl Almaʿ, fall into this category.
Advancing the Open Modeling Interface (OpenMI) for integrated water resources modeling

Abstract The use of existing component-based modeling frameworks for integrated water resources modeling is currently hampered for some important use cases because they lack support for commonly used, topology-aware, spatiotemporal data structures. Additionally, existing frameworks are often accompanied by large software stacks with steep learning curves. Others lack specifications for deploying them on high performance, heterogeneous computing (HPC) infrastructure. This puts their use beyond the reach of many water resources modelers. In this paper, we describe new advances in component-based modeling using a framework called HydroCouple. This framework largely adopts the Open Modeling Interface (OpenMI) 2.0 interface definitions but demonstrates important advances for water resources modeling. HydroCouple explicitly defines standard and widely used geospatial data formats and provides interface definitions to support simulations on HPC infrastructure. In this paper, we illustrate how these advances can be used to develop efficient model components through a coupled urban stormwater modeling exercise.
Limited Influence of Sediment Grain Size on Elemental XRF Core Scanner Measurements

X-ray fluorescence (XRF) scanning of sediment cores allows the rapid acquisition of bulk geochemical data at high resolution. The XRF core scanner data, which are expressed as elemental counts or peak areas, are mainly related to elemental concentrations, but they are also influenced by a series of sediment physical properties that vary with depth, such as bulk density, water content, organic matter content, and grain size. Here, we investigate the influence of grain size on elemental XRF peak areas by comparing ITRAX XRF core scanner measurements to ICP-AES elemental concentration for two sediment cores with variable grain size. Results provide evidence for a limited influence of sediment grain size on XRF peak areas. This influence is negligible for sediment cores with grain-size variations of 10 μm or less. Our data also demonstrate that for cores with large grain-size variations, correcting the peak areas for water content improves the precision of the XRF measurements by a factor of three. This study therefore demonstrates that, for most sediment cores, the precision of data obtained by XRF core scanning is not significantly altered by grain-size variations.
VISUAL DISPLAY UNIT FOR A SCUBA DIVING MASK.

Visual display unit (100) for a scuba diving mask (122) with which a diver is equipped and which is provided separately from said mask, said unit comprising a first electronic display unit (102), a second display unit (104) arranged downstream of said first display unit and arranged for receiving a luminous flux (120) emitted by said first display unit (102) and reflecting at least one portion of said luminous flux (120) in the direction of said diver's eyes (106), wherein said second display unit is at least partially transparent; and is arranged at a constant distance from said first display unit (102). The document also relates to a diving mask equipped with such a device.
Estimating Head Rice Yield of Long-Grain Rice using a Bending Force Instrument

Abstract. Head rice yield is an important index of rice quality. The official procedure for determining head rice yield requires a 1000-g sample of rough rice or a lesser sample of rough rice for a modified procedure. In certain situations, such amounts of rough rice may not be available for conducting an actual milling analysis; thus, there is a need to provide alternative methods of estimating head rice yield using a smaller sample. In this study, a PaddyCheck instrument was used to individually measure the three-point bending strength of approximately 250 rough rice kernels per sample. The instrument then classified the kernels as either “hard,” “soft,” or “broken by a force &amp;lt;17 N” (BBF). Additionally, each kernel was individually illuminated using polarized light as a means of estimating chalkiness. The kernel parameters measured using the PaddyCheck were then used to develop an equation for estimating head rice yield, based upon head rice yields determined using a modified milling procedure. The equation developed could be used in conjunction with the PaddyCheck instrument to provide estimates of head rice yield and thus, might allow the instrument to be more useful to practitioners in breeding programs and others involved in harvesting and drying operations to compare head rice yields of various samples/treatments, where the available rough rice sample or time is not sufficient to conduct an actual milling analysis. Keywords: Breaking force, Head rice yield, PaddyCheck, Rice milling, Rice quality, Rough rice.
Italian operatic fantasies in Latin America

Abstract This article locates the beginnings of operatic globalization in the years around 1830, following the scattered appearances of opera outside Europe in the eighteenth century, and before the vast international expansion of performances after 1850. Between the two, a potent fantasy of opera spreading throughout the world coincided with a widespread attention to touring groups in the Americas and elsewhere, communicated through the transcontinental circulation of newspapers. For the newly independent republics of South America, meanwhile, Italian opera also offered an opportunity to turn away from Spanish influence. As a result, however, this opera was not typically defined through its values of italianita, as would be the case later in the century. Instead, the music of Gioachino Rossini, and later Vincenzo Bellini, became bound up in intricate ways with local and international allegiances, as can be illustrated through comparison of the situation in Buenos Aires and Montevideo.
Mechanisms of Activation of Receptor Tyrosine Kinases: Monomers or Dimers

Receptor tyrosine kinases (RTKs) play essential roles in cellular processes, including metabolism, cell-cycle control, survival, proliferation, motility and differentiation. RTKs are all synthesized as single-pass transmembrane proteins and bind polypeptide ligands, mainly growth factors. It has long been thought that all RTKs, except for the insulin receptor (IR) family, are activated by ligand-induced dimerization of the receptors. An increasing number of diverse studies, however, indicate that RTKs, previously thought to exist as monomers, are present as pre-formed, yet inactive, dimers prior to ligand binding. The non-covalently associated dimeric structures are reminiscent of those of the IR family, which has a disulfide-linked dimeric structure. Furthermore, recent progress in structural studies has provided insight into the underpinnings of conformational changes during the activation of RTKs. In this review, I discuss two mutually exclusive models for the mechanisms of activation of the epidermal growth factor receptor, the neurotrophin receptor and IR families, based on these new insights.
Aumentare la competitività di WIEPOL introducendo nuovi prodotti sul mercato a seguito di lavori di R & S commissionati

A seguito dell'investimento previsto, verranno fabbricati nuovi prodotti: cioccolato al latte e cioccolato da dessert con proprietà salutari migliorate. Il progetto sarà realizzato in una sola fase e riguarda l'acquisto dell'installazione e della messa in servizio di un'innovativa linea di produzione automatica di cioccolato, che comprende: — premiscelatore — dispositivo di premescolazione degli ingredienti di cioccolato — mulino per la produzione di cioccolato, — consza, per la lavorazione del cioccolato insieme a dispositivi cooperanti con la linea composta da: — infrastruttura di trasporto di materie prime per premiscelatore, mulino e equiseto e cioccolato per serbatoi tampone e stoccaggio, — automazione del dosaggio di materie prime e prodotti finiti — serbatoio da 30 tonnellate, prodotto finito, — stazione di scarico Big-Bag. La linea di produzione automatica del cioccolato sarà dotata di automazione integrata di controllo del processo di preparazione delle materie prime e del processo produttivo insieme a un modulo di memoria per il risparmio di ricette. Inoltre, verranno acquistati software per il salvataggio e l'analisi dei risultati ricevuti, contenenti moduli quali: Definizione della tecnologia, configurazione del prodotto, pianificazione della produzione, implementazione della produzione, supervisione e rendicontazione, regolamento di produzione, completamento. Il software sarà integrato nel sistema IT esistente "ProExpert SQL Version II". Oltre al gruppo di consumatori individuali, in particolare bambini e donne incinte, gli atleti, i nuovi prodotti saranno destinati ai produttori di cioccolato e dolciumi. Poiché i prodotti offerti avranno una lunga durata di conservazione, i loro destinatari saranno anche servizi uniformi.
Optimal investment to enable evolutionary rescue

'Evolutionary rescue' is the potential for evolution to enable population persistence in a changing environment. Even with eventual rescue, evolutionary time lags can cause the population size to temporarily fall below a threshold susceptible to extinction. To reduce extinction risk given human-driven global change, conservation management can enhance populations through actions such as captive breeding. To quantify the optimal timing of, and indicators for engaging in, investment in temporary enhancement to enable evolutionary rescue, we construct a model of coupled demographic-genetic dynamics given a moving optimum. We assume 'decelerating change', as might be relevant to climate change, where the rate of environmental change initially exceeds a rate where evolutionary rescue is possible, but eventually slows. We analyze the optimal control path of an intervention to avoid the population size falling below a threshold susceptible to extinction, minimizing costs. We find that the optimal path of intervention initially increases as the population declines, then declines and ceases when the population growth rate becomes positive, which lags the stabilization in environmental change. In other words, the optimal strategy involves increasing investment even in the face of a declining population, and positive population growth could serve as a signal to end the intervention. In addition, a greater carrying capacity relative to the initial population size decreases the optimal intervention. Therefore, a one-time action to increase carrying capacity, such as habitat restoration, can reduce the amount and duration of longer-term investment in population enhancement, even if the population is initially lower than and declining away from the new carrying capacity.
LAVAGREEN

FINALIDADE: OBJETIVOS DA TRANSIÇÃO DIGITAL: — INTEGRAÇÃO DAS TECNOLOGIAS DIGITAIS NOS PROCESSOS DE PRODUÇÃO: INTERVENÇÕES FUNCIONAIS PARA A INTEGRAÇÃO DE TECNOLOGIAS DIGITAIS NO CICLO PRODUTIVO DA EMPRESA — DIGITALIZAÇÃO DAS RELAÇÕES DE FORNECIMENTO COM TERCEIROS NA CADEIA DE ABASTECIMENTO/CADEIA DE VALOR: INTERVENÇÕES FUNCIONAIS PARA MELHORAR A INTEGRAÇÃO DA EMPRESA COM SUA PRÓPRIA CADEIA DE SUPRIMENTOS — IMPLEMENTAR SISTEMAS DE PAGAMENTO DIGITAL: INTERVENÇÕES FUNCIONAIS PARA A UTILIZAÇÃO DE SISTEMAS DE PAGAMENTO DIGITAIS À: OBJETIVOS DA TRANSIÇÃO ECOLÓGICA: — AUMENTAR A EFICIÊNCIA ENERGÉTICA DO SISTEMA DE PRODUÇÃO: INTERVENÇÕES FUNCIONAIS PARA REDUZIR O CONSUMO DE ENERGIA OU, EM QUALQUER CASO, PARA BAIXO CONSUMO DE ENERGIA, PARA RACIONALIZAR OS FLUXOS DE ENERGIA E MINIMIZAR QUALQUER DESPERDÍCIO DE ENERGIA, PARA RECUPERAR OU MELHORAR A ENERGIA DISPERSAFINALITÃ Ã Â: OBJETIVOS DE SEGURANÇA: — AUMENTAR A SEGURANÇA DOS TRABALHADORES, CLIENTES/UTILIZADORES E FORNECEDORES: INTERVENÇÕES FUNCIONAIS NA MELHOR DAS HIPÓTESES
CLOTHING TREATMENT APPARATUS

A clothing treatment apparatus according to one aspect of the present disclosure comprises: a cabinet provided with an inlet port through which clothing is introduced; a tub provided inside the cabinet and having a tub inlet part through which the clothing can be introduced; a drum rotatably provided inside the tub and accommodating the clothing; a driver for rotating the drum; an induction module for heating the drum; a gasket provided to be stretchable and connecting the inlet port and the tub inlet part; and a communication part for communicating the inside of the tub and the outside of the cabinet. During a drying cycle of the clothing, the revolutions per minutes (RPM) of the drum can be increased to a target RPM at which there is at least one section in which the tub can resonate in accordance with the rotation of the drum.
Beyond weird witnesses: eyewitness memory in cross-cultural contexts

Our increasingly international society demands that eyewitnesses of serious crimes regularly provide testimony in cross-cultural settings, such as international criminal tribunals. This poses significant challenges for investigators and legal decision-makers. Errors in fact-finding may result in wrongful convictions and unjust acquittals. Yet, eyewitness memory research has predominantly focused on Western, Educated, Industrialized, Rich, and Democratic (WEIRD) witnesses. 

The project addresses two key objectives: (1) develop culturally modulated theory of eyewitness memory and (2) design and test evidence-based interview guidelines. 

In Subproject 1, I will examine what happens when police investigators interview eyewitnesses from a different cultural background. It will involve the systematic coding of culture-dependent variables in video-recorded police interviews with witnesses of serious crimes in South Africa, a society with many different subcultures. 

In Subproject 2, I will analyse the frequency, nature and legal consequences of culture-dependent variables in international criminal cases. It will involve an empirical document analysis of eyewitness evidence provided at the International Criminal Tribunal for Rwanda, and interviews with international legal scholars and practitioners. 

In Subproject 3, I will assess how different cultural groups encode, store and retrieve memories, and how memory reports are evaluated in immigration contexts. It will involve a series of experiments in which the objective and perceived characteristics of statements provided by asylum seekers originating from Sub-Saharan Africa are compared to a matched Western control group.

The project integrates analyses of video, document and experimental data to provide insight into culture-dependent variables in eyewitness memory. The new theory will enable researchers and practitioners to steer away from the present WEIRD bias in legal psychology.
PRODUCTION OF A DENSE MIST OF MICROMETRIC DROPLETS IN PARTICULAR FOR EXTREME UV LITHOGRAPHY

The invention concerns a method and a device for producing a dense mist of micrometric and submicrometric droplets, used for light generation in the extreme ultraviolet in particular for lithography. The invention is characterised in that it consists in injecting pressurised liquid (4) into a nozzle (10) with a small diameter emerging into vacuum. Light (42) is generated by focusing a laser radiation (36) onto the dense mist (23).