SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
A study on enhanced recovery after abdominal surgery

Background Enhanced recovery after surgery or fast-track surgery is a set of protocols aimed to reduce the physiological burden of surgery, thus improving outcomes. Fast-track surgery aims to use evidence-based practice to reduce complications, improve postoperative quality of life, and decrease hospital length of stay. Aims The aim of the study was to investigate the effect of applying enhanced recovery after surgery (ERAS) protocols on patients undergoing different abdominal operations. Settings and design The study was a prospective observational study that was conducted on 25 patients of ASA grades I-III, aged between 15 and 65 years, with different abdominal pathologies who were to undergo elective operations between August 2013 and May 2014. Materials and methods Patients were subjected to ERAS protocols. All patients were monitored in the hospital as needed until the patient fulfilled the discharge criteria (adequate oral intake; pain well controlled with oral analgesics; ability to void without difficulty; able to ambulate independently or at baseline levels; the patient believing he is ready for discharge and able to look after himself at home). Statistical analysis was performed using SPSS. Descriptive statistics were expressed as mean ± SD unless otherwise stated. Results The ERAS program has been proven to be safe, not only in reducing postoperative hospital stay and morbidity but also in improving patient convalescence. Conclusion The ERAS program had a significant role in reducing the duration of hospital stay as well as morbidity in patients undergoing major abdominal surgery.
TECNIFORMA Anpassung der Zukunft

Projekt zur Neuorganisation des Unternehmens in einer Perspektive der Anpassungsfähigkeit und Sicherheit im Rahmen des Covid-19-Deconfination-Prozesses und der allmählichen Erholung der Wirtschaftstätigkeit soll den Mitarbeitern, Kunden und anderen Partnern Sicherheit und Vertrauen bieten.
State regulation or state capitalismc: a systems approach to crisis prevention and management

The recent economic and financial crisis of 2007−2009 and the ongoing recession in Europe have shown the inadequacy of classic concept of capitalism. The rationality of economic agents and self-regulation of markets have been questioned. Views on the future of capitalism range from its fine-tuning to the complete overhaul. This paper argues that economic regulation might be a better option if a systems approach is used as its underlying methodology. To illustrate the point, we analyse the financial sector from the viewpoint of a network organisation. Without a systems administrator, the network effects, including the systemic risk, cannot be internalised by the markets themselves. Markets are living systems, similar to complex biological systems. Just as full spontaneity is absent in the world of living beings, so it is absent in the world of the economy. The sustained regulation of collective behaviour of economic agents is needed for capitalism to survive.
Metabody: body metacognition, mentalization and metamorphosis

We live in a socio-economic world that affords us with increasing options and technologies to control and present our bodily appearance to others, including by managing our eating habits, or by digital and even surgical body modification. These proliferating phenomena raise the age-old question of how we negotiate the balance between the invariance and invention of our identity. Addressing this question in relation to modern body image phenomena requires a radical new way of studying the concept of body image. METABODY proposes the novel concept of Body Imagining to capture the idea that our body image is not a fixed representation in the brain, but rather a dynamic inference based on prior expectations and new information. Studying the balance between prior beliefs and new information could thus hold the key to understanding modern body image phenomena. Moreover, existing studies have failed to investigate the metacognitive level of these inferences. METABODY will test the novel hypothesis that body image disturbances are not the result of biases merely in the 1st order ability to perceive one’s body, but also in the 2nd order ability to evaluate the reliability of these perceptions in given contexts. Specifically, three empirical work-packages will study how individuals balance their own embodied experience against: (1) external perspectives on the body during multisensory perception (Body Metacognition), (2) social perspectives during interpersonal encounters (Body Mentalizing) and (3) future and ideal body perspectives during decisions about body modification options with uncertain outcome (Body Decision Making). Ultimately, METABODY will address in innovative ways the timely question of how we negotiate the balance between the invariance and invention of our identity in a time when changing the body is offered as an easy way to change the self.
Improved hydration performance of microcellulose in cement

A variety of systems, methods and compositions are disclosed, including, in one method, a method of cementing may comprise providing a cement composition comprising a hydraulic cement, water, and a microcellulose additive, wherein the microcellose additive may comprise microcellulose with a metal deposited on a surface of the microcellose, wherein the metal may be selected from the group consisting of an alkali metal, an alkaline earth metal, and combinations thereof; placing the cement composition in a selected location; and allowing the cement composition to set.
VIA NOVA – Healthy Mobility and Intelligent Intermodality In Alpine Areas

VIANOVA with partners from all the 7 Alpine countries is a project that aims to reduce car traffic (shift solo car trips) and at the same time to motivate the inhabitants for non-motorised and sustainable modes of transport based on physical activities (cycling & walking). A cross-sectoral approach (land use planning - mobility – health) will combine measures that fit perfectly to the sensible Alpine Space. The model like demonstrations will be implemented on 3 levels. 1) Improvement of objective situation of public space for physical activities (air quality, infrastructure, barriers, organisation, intermodality), 2) Improvement of perception of public space for cycling / walking and 3) User motivation for sustainable model choice. Results will be: well documented case studies, training sessions & materials for planners and policy recommendations.
Chemometers for in situ risk assessment of mixtures of pollutants

CHEMO-RISK aims for a novel scientifically sound chemical risk assessment paradigm that integrates exposure and effect assessment of a broad range of chemicals into a single procedure and provides information relevant to ecosystem and human health. The key innovation is polymer “chemometers” that will be equilibrated with their surroundings and deliver information on the pollutant’s chemical activity in the environment, biota, and humans. A chemometer functions analogously to a thermometer, but instead of the temperature, it yields a measure of chemical activity. Chemical activity in turn indicates the thermodynamic potential for, e.g., partitioning, biouptake and toxicity. CHEMO-RISK aims at breaking the current paradigm in environmental risk assessment of single chemicals that disregards bioavailability, ignores mixture effects, lacks site-specificity and is difficult to extrapolate to human health.
The chemometer extracts will be investigated using top-notch (a) GC and LC/Orbitrap chemical analysis to characterise the pollutant mixtures and (b) cell-based reporter gene bioassays to determine mixture effects covering baseline toxicity, specific (e.g., endocrine disruption) and reactive (e.g., genotoxicity) modes of toxic action and adaptive stress responses. Within CHEMO-RISK, the following important research questions will be tackled: (A) Which processes drive the enrichment of pollutants in aquatic biota on a thermodynamic basis? (B) How do pollutants distribute within an organism, and which effects do they elicit at the key target sites? (C) Can we apply everyday-life items such as eyeglass-nose pads to replace invasive sampling in human health risk assessment? (D) To which degree can non-target analysis of chemometer extracts explain the observed toxicity profiles across media? By combining all these research efforts, CHEMO-RISK will provide a unified risk assessment paradigm with risk-based trigger values distinguishing acceptable from unacceptable effects.
Method: a single nucleotide polymorphism genotyping method for Wheat streak mosaic virus

BackgroundThe September 11, 2001 attacks on the World Trade Center and the Pentagon increased the concern about the potential for terrorist attacks on many vulnerable sectors of the US, including agriculture. The concentrated nature of crops, easily obtainable biological agents, and highly detrimental impacts make agroterrorism a potential threat. Although procedures for an effective criminal investigation and attribution following such an attack are available, important enhancements are still needed, one of which is the capability for fine discrimination among pathogen strains. The purpose of this study was to develop a molecular typing assay for use in a forensic investigation, using Wheat streak mosaic virus (WSMV) as a model plant virus.MethodThis genotyping technique utilizes single base primer extension to generate a genetic fingerprint. Fifteen single nucleotide polymorphisms (SNPs) within the coat protein and helper component-protease genes were selected as the genetic markers for this assay. Assay optimization and sensitivity testing was conducted using synthetic targets. WSMV strains and field isolates were collected from regions around the world and used to evaluate the assay for discrimination. The assay specificity was tested against a panel of near-neighbors consisting of genetic and environmental near-neighbors.ResultEach WSMV strain or field isolate tested produced a unique SNP fingerprint, with the exception of three isolates collected within the same geographic location that produced indistinguishable fingerprints. The results were consistent among replicates, demonstrating the reproducibility of the assay. No SNP fingerprints were generated from organisms included in the near-neighbor panel, suggesting the assay is specific for WSMV. Using synthetic targets, a complete profile could be generated from as low as 7.15 fmoles of cDNA.ConclusionThe molecular typing method presented is one tool that could be incorporated into the forensic science tool box after a thorough validation study. This method incorporates molecular biology techniques that are already well established in research and diagnostic laboratories, allowing for an easy introduction of this method into existing laboratories. Keywords: single nucleotide polymorphisms, genotyping, plant pathology, viruses, microbial forensics, Single base primer extension, SNaPshot Multiplex Kit
Ferroelectric domain structure of the BiFeO3 film grown on different substrates

Abstract Domain structure of BiFeO 3 (BFO) films grown on different substrates, with a conductive La 0.7 Sr 0.3 MnO 3 underlayer, has been experimentally studied. Two oppositely orientated polarizations, along the long body diagonal to the perovskite unit cell of BFO, are detected in the BFO films on the (0 0 1)-oriented NdGaO 3 . Electric pulses applied in the [0 0 1] direction produce a polarization switching, resulting in the domain structure characterized by the 109° domain walls. Contrary to the BFO films on NdGaO 3 , the BFO films on SrTiO 3 (0 0 1) exhibit a much complex domain structure. Both 71° and 109° domain walls are possible with a uniform polarization component pointing to the bottom electrode.
Smart manufacturing for Alpine Space SMEs

The EU manufacturing sector, apart from financial services, is the second largest sector in terms of employees & turnover and the first contributor to non-financial business economy. Exports consist mainly of manufactured products. This sector plays an essential role in the innovation chain because is RD&I-intensive activity. Nowadays, lack of automation, synergies and obsolete management systems cause loss of competitiveness with respect to emerging markets. In order to meet the challenge of producing future products and meeting emerging social needs and megatrends also in the alpine space (AS), the contribution of digital technologies is crucial. Owing to their impact (often with disruptive consequences) on many sectors of the economy and the services, digital technologies(DT) are changing the world of industrial production with the so-called Fourth Industrial Revolution. This affects the whole manufacturing value chain, i.e. production, logistics, assistance, quality and safety, especially for the AS industry, where these approaches need to be strongly adapted to the specificity of the Alpine area. In return, smart manufacturing technologies can help industries to be much more connected and able to connect their own assets (physical, human resources, information and internal and external data) gaining in competitiveness, productivity and safety._x000D_
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SMART-SPACE project intends to strengthen the cooperation within the system of innovation to promote smart digital solutions to traditional industrial sectors according to PPs; S3. SMART-SPACE will identify an Alpine Smart Manufacturing strategy, able to combine Alpine social&economic challenges, geographical and industrial peculiarities, environmental sustainability and entrepreneurship. An Alpine Strategic partnership will be set up to implement a common action plan to be supported by a Digital Innovation Hub, a competence centre to assist all innovation actors to trigger Alpine growth and wellness.
Posterolaterale Rekonstruktion des Kniegelenks nach Larson

Posterolateral soft-tissue reconstruction to restore knee kinematics in isolated or combined posterolateral instabilities.Isolated or multiligament knee injuries with posterolateral insufficiency (popliteus tendon, lateral collateral ligament [LCL], popliteofibular ligament).Arthrofibrosis. Severe varus deformity. Fixed posterior drawer. Doubts about compliance.Graft harvest of semitendinosus tendon. In cases with multiligament reconstruction or associated posterior cruciate ligament (PCL) reconstruction contralateral graft harvest. Suture at 24 cm with baseball stitches using biodegradable material. Two-incision technique: one over the fibular head, one over the lateral epicondyle. Dissection along the biceps femoris to identify and free the peroneal nerve. Kirschner wire-guided creation of a 4.5-mm tunnel through the fibular head. Longitudinal incision of tensor fasciae latae and Kirschner wire drilling at the insertion of the LCL and the politeus tendon. Isometric testing. Overdrilling with an appropriately sized drill (6-7 mm, depth 40 mm). Graft passage through the fibular head and underneath biceps muscle and tensor fasciae latae into the femoral tunnel. Fixation with a biodegradable interference screw at 70° knee flexion in slight internal rotation.Defensive rehabilitation due to associated PCL reconstruction using a Posterior Tibial Support (PTS) brace for 6 weeks (day and night). PCL brace with limited range of motion for the next 6 weeks and PTS brace at night. Rehabilitation in a prone position.42 patients (10/2003-10/2006) with posterolateral reconstruction according to Larson. All patients received combined PCL and posterolateral reconstruction. No intraoperative complications, one patient with hematoma in the popliteal fossa (conservative treatment), two patients with hematoma following contralateral graft harvest. At followup after 2.6 years, 40 patients were enrolled showing high improvement according to IKDC (International Knee Documentation Committee) and Lysholm Scores.
Should walking aids be used in the assessment of walking in persons with stroke?

Results: The results of the multiple regression analysis revealed that the number of single heel-raise repetitions and the passive range of motion for the ankle joint (dorsi-flexion with the knee flexed) were significantly correlated with the one-step value. Conclusion(s): Our data indicated that both an increased number of single heel-raise repetitions and passive range of motion for the ankle joint (dorsi-flexion with the knee flexed) were associatedwith a greater one-step value. In other words, the acquisition of plantar-flexion strength and greater dorsi-flexion angle more rapidly led to the patient’s ability to resume a normal gait after Achilles tendon repair. The onestep test is affected by the strength and mobility of the ankle and is useful as an ankle joint function evaluation tool. Implications: The one-step test is an evaluation tool for ankle joint function that is easily measurable anywhere. This new test for patients after Achilles tendon repair is clinically significant.
Choroidal thickness after intravitreal ranibizumab injections for choroidal neovascularization

To study changes in choroidal thickness with ranibizumab treatment for choroidal neovascularization (CNV).Prospective case series.This prospective study consisted of 60 CNV-affected eyes of 60 patients treated with intravitreal injections of ranibizumab using an on-demand protocol after an initial loading phase. The eyes studied included 20 with age-related macular degeneration (AMD), 20 with polypoidal choroidal vasculopathy (PCV), and 20 with myopic CNV. In the eyes with AMD and PCV, choroidal thickness at the fovea was measured with optical coherence tomography using enhanced depth imaging. In eyes with myopic CNV, the choroidal thickness was measured using standard optical coherence tomography without the enhanced depth imaging technique.With ranibizumab treatment, central retinal thickness decreased significantly (P < 0.001) and visual acuity improved significantly (P < 0.001). However, central choroidal thickness (167.2 ± 108.3 μm) showed no significant change at 1 month after the loading phase (165.2 ± 107.8 μm, P = 0.120) or at final examination (164.8 ± 107.7 μm, P = 0.115). At baseline, central retinal thickness in eyes with AMD was significantly greater that those with PCV (P = 0.005) or high myopia (P = 0.029). However, central choroidal thickness in eyes with myopic CNV was significantly thinner than in eyes with AMD (P < 0.001) or PCV (P < 0.001). In each type of disease, there was no significant change in central choroidal thickness with ranibizumab treatment.The effect of ranibizumab on the choroidal thickness is minimal, if any.
Evaluation of CTNNB1 and TP53 variability in patients with hepatocellular carcinoma and occult hepatitis B virus infection

Hepatitis B virus (HBV) infection plays a major role in hepatocellular carcinoma (HCC) development. Much evidence suggests that HBV also maintains its pro-oncogenic properties in cases of occult HBV infection (OBI). Mutations of the beta-catenin and p53 genes (CTNNB1 and TP53, respectively) may be associated with HCC occurrence in patients with overt HBV infection, whereas such genetic mutations have not been investigated in HCC patients with OBI thus far. We investigated the genetic heterogeneity of CTNNB1 exon 3 and all of the TP53 exons in tumor DNA extracts from a unique cohort of 61 HCC patients (all previously tested for HBV DNA and for its integration into the host's genome), including 34 OBI-positive, 20 HBV surface antigen (HBsAg)/OBI-negative, and 7 HBsAg-positive cases. No CTNNB1 exon 3 mutations or TP53 mutations were detected in any case. The homo- or heterozygous TP53 R72P polymorphism was found in 18 of 61 cases (29.5%), although no differences in its prevalence between OBI and non-OBI cases as well as between cases with and without viral integration were revealed. In conclusion, CTNNB1 and TP53 somatic mutations seem to be a rare event in patients with HCC in our area and in cases with either overt or occult HBV infection.
Fostering knowledge and applications of new aerogel superinsulation in architecture and construction

Old, poorly insulated buildings represent a tremendous potential  for saving energy in Europe. Aerogel building materials are characterized by very low thermal conductivities and ideal physical properties in building applications both in retrofits and new constructions. While several products have been developed and become commercially available in the last decade, knowledge with building professionals - such as architects, building designers, engineers and owners on their successful practical application in different contexts is still sparse. This hinders the implementation of available solutions as well as the development of new ones based on aerogels, which have the potential to play a significant role in the reduction of energy consumption in buildings and thus in meeting EU climate and energy goals. 
It is hence proposed, in a first work package (WP1), to document and analyse the usage of aerogel building materials in Switzerland and the EU by studying and measurement of realised retrofits and applications in new buildings. This data and its analysis will be made available within an online data base. In the second and third part will be bring unique new combinations of aerogel composite materials for architecture and construction (WP2) and new aerogel insulation for cavity walls of existing buildings (WP3). Subsequently (WP4) by studying building applications and their performance in terms of energy and costs, guidelines for the use of aerogel building materials will be developed, verified by simulation and published. For the first time building professionals will have free access to a comprehensive and unbiased body of knowledge detailing where and how aerogel building materials can be used. Crucial to the proposed work is its multidisciplinary approach which joins the architectural expertise of the researcher with the knowledge and experience of the hosting laboratory in material development, which constitutes an ideal framework for truly innovative research.
Bioengineer novel eco-friendly natural colour fibre through genetic manipulation of the phenylpropanoid and betalain pathways in cotton

Cotton fibre is one of our most important textile resources. Most commercial cotton fibres are various shades of white but can be yellowish because of poor environmental conditions during growth or storage. A bleaching step is employed to address this issue during cotton fabric processing. After cotton fibre is spun into yarn, a dyeing process is applied to colour natural fibre to satisfy costumer’s demand. Additional industrial processes are needed to remove unfavourable natural colours and then add desirable colours to the yarn. Each step costs substantial amounts of energy but more importantly causes serious water and air pollution. More than 100 litres of water are required to dye one kilogram of cotton. The industrial effluents are rich in hazardous material. To address these issues, the proposed research will aim to bioengineer high value eco-friendly naturally coloured cotton fibre.  Two overall strategies will be pursued. Firstly, by down-regulating key genes in the phenylpropanoid pathway, we aim to reduce fibre yellowish to increase fibre whiteness for the premium market. Second, by reorientating the metabolic flux from the phenylpropanoid pathway into a heterologously expressed betalain biosynthesis pathway, we aim to engineer novel natural colour cotton. The prospective products will significantly alleviate the environmental issues of the textile industry where 20% of global water pollution is produced and provide a biotechnological solution for a more environmentally friendly textile industry.