SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
A multidisciplinary approach for the stratification of patients with carotid artery disease

Carotid artery disease, the primary trigger of ischaemic cerebrovascular events including stroke, causes major morbidity, mortality and healthcare costs worldwide. Still, treatment is based on criteria established in the 90s that do not take into account the molecular evolution we have witnessed since, nor the introduction of new medication, leading to remarkably high unnecessary surgical treatment while missing most patients at risk. 
TAXINOMISIS will provide novel disease mechanism-based stratification for carotid artery disease patients to address the needs for stratified and personalised therapeutic interventions in the current era. This will be achieved through (1) the dissection of mechanisms mediating carotid artery disease, and identification of susceptibility and protection factors of plaque erosion and/or rupture using longitudinal cohorts and multi-omics, (2) the definition of distinct disease phenotypes and endotypes, and generation of molecular fingerprints of high versus low-risk states through systems medicine, (3) the development of a multilevel risk prediction model of the symptomatic plaque incorporating new biomarkers and advanced imaging, implemented in a software, to assist patient stratification and clinical decision making, (4) the development of novel pharmacogenomics solutions based on lab-on-a-chip technology to support personalized treatment, (5) the evaluation of the new risk prediction model and lab-on-a-chip device in a prospective observational clinical study, and (6) the assessment of regulatory, cost-effectiveness and ethical issues towards the implementation and commercialization of the programme’s outcomes.
TAXINOMISIS has therefore the potential to rationally change the current state-of-the-art in the stratification of patients with carotid artery disease by reducing unnecessary operations, refining medical treatment and opening up new avenues for therapeutic intervention, while strengthening the European biotechnology sector.
A method for generating document summary using field association knowledge and subjectively information

In the recent years, with the expansion of the Internet there has been tremendous growth in the volume of electronic text documents available information on the Web, which making difficulty for users to locate efficiently needed information. To facilitate efficient searching for information, research to summarize the general outline of a text document is essential. Moreover, as the information from bulletin boards, blogs, and other sources is being used as consumer generated media data, text summarization become necessary. In this paper a new method for document summary using three attribute information called: the field, associated terms, and attribute grammars is presented, this method establish a formal and efficient generation technology. From the experiments results it turns out that the summary accuracy rate, readability, and meaning integrity are 87.5%, 85%, and 86%, respectively using information from 400 blogs.
Microbial production of custom-made, pure and sustainable anthocyanins

The colour industry is undergoing a radical change as it moves from harmful, synthetic colorants to natural, plant-based colour compounds. This change creates several problems as natural colours are poor in quality, they are impure and they compete directly with agricultural land use and food. To overcome these limitations, at N-CHROMA we have developed a new revolutionary technology to produce colour compounds suitable for the Food & Beverage and Colour Cosmetics industries. We do this by using microorganisms to produce custom-made, high quality and pure anthocyanin compounds in a sustainable and cost effective manner. To achieve this we are using baker’s yeast as a microbial cell factory to produce stable anthocyanins. This class of colour compounds shows advanced characteristics in terms of stability to pH changes, making them more attractive to the target markets. 

With the SME instrument phase 1 grant, we aim to assess the functionality of our ingredients to existing products. Also, the cost-in-use of our highly pure compounds will be assessed during the technical feasibility study. In addition, we will perform commercial feasibility studies for the use of anthocyanins in the cosmetic, personal care and nutraceutical markets. Such markets have not been investigated so far but they hold great potential for anthocyanins due to their high antioxidant activity and biological function.
CHEMICAL METHOD FOR LIGNIN DEPOLYMERIZATION

The present invention claims a new method to depolymerize and/or modify lignin or lignin related compounds by using copper, a copper coordination compound and peroxide in an aqueous solution. The copper coordination compound is applied in concentrations below 20 % preferably at 0.001-5 % in aqueous solutions. The coordination compounds include compounds containing nitrogen, such as pyridine, histidylglycine, phthalocyanine, acetonitril; containing a hydroxyl group, such as catechol; containing ether, such as 18-crown-6; containing sulfur, such as mercaptosuccinic acid; or containing olefinic double bonds, such as 1,3-cyclohexadiene. Peroxide can be added externally as hydrogen peroxide or as organic perioxide or as peracid or can be produced in the lignin containing solution by peroxide producing chemical reactions.
Sustainability

“Sustainable development is development that meets the needs of the present without compromising the ability of future generations to meet their own needs”. This much-quoted definition from the Brundtland Report of the World Council on Economic Development (WCED, 1987) captures what most people would agree is the principle of sustainability. This chapter examines the meaning of sustainability in a materials context. The view you take of it depends on scale – local or global – and on the time frame – weeks, years, centuries. The chapter starts by examining approaches, starting from the short-term Pollution Control and Prevention, through Design for the Environment, ideas of Industrial Ecology, finally broadening to Sustainable Development. It then examines the parallel, coupled flows of energy, biomass and materials from source to sink, focusing ultimately on material sustainability. This involves an survey of sustainable and quasi-sustainable materials, bio-derived polymers and bio-composites.
Lietsu servicest Oy — Un hotel de apartamentos experiencial y concepto de servicio de viajes en el norte de Karelia

El objetivo del proyecto es lanzar el negocio de un hotel de apartamentos orientado a un mercado internacional y traer nuevos flujos turísticos al norte de Karelia y al crecimiento internacional de la empresa como proveedor de servicios turísticos experienciales e integrales.
Instructional Leadership in Compulsory Schools in Iceland and the Role of School Principals

The purpose of this paper is to present findings from a study of instructional leadership in 20 Icelandic compulsory schools. More specifically, the perceptions of staff concerning supervision of instruction, and the views of principals regarding their role as supervisors of instructional development. Data was collected with questionnaires from staff and interviews with principals. The approach was based on a mixed-methods design. The findings indicate that supervision of instruction differs between the schools. Principals provide for little direct supervision of teachers, however, they provide considerable indirect supervision. The supervision of instruction suggests that collegial supervisory emphasis is considerable in most of the schools. The collegial model, however, emphasizes systematic collection of data on what happens in classrooms, an important element that is largely neglected in the Icelandic schools.
How limiting factors drive agricultural adaptation to climate change

Abstract Consensus is growing that agriculture is vulnerable to climate change and adaptation responses are necessary to minimize impacts. Nonetheless, the diversity of potential impacts, agro-ecological contexts and regional capacity for change make understanding adaptation behaviors challenging and ensure that climate change adaptation will not be the same across all contexts. Considering this heterogeneity, this paper aims to develop a theoretical approach to connect agro-ecosystem diversity with farmer decision-making in the context of agricultural adaptation to climate change. We combine the ecological principle of Liebig’s Law of the Minimum with the Psychological Distance Theory to suggest how adaptation behaviors vary across regional contexts. We argue with our limiting factors hypothesis that limiting factors within a farm system (water or temperature impacts) influence the adoption of adaptation practices differently across regions and farm systems. Limiting factors varied across farm systems and regions, based on historical climate changes, agro-ecological contexts, infrastructure and adaptation capacity. Using farmer survey data from New Zealand we show that limiting factors mediate the effect of past climate experiences on the adoption of adaptation strategies differently in two regions with water acting as a limiting factor in Hawke’s Bay and water and temperature as a limiting factor in Marlborough. This suggests that farmers perceive and respond to climate change in part due to their personal experiences with climate change and the limiting factors within their system. Such results are relevant for the development of regional adaptation strategies, effective policies and targeted climate change communication.
Mont-Blanc 3, european scalable and power efficient hpc platform based on low-power embedded technology

The main target of the Mont-Blanc 3 project ""European Scalable and power efficient HPC platform based on low-power embedded technology"" is the creation of a new high-end HPC platform (SoC and node) that is able to deliver a new level of performance / energy ratio whilst executing real applications.
 
The technical objectives are:
 
1. To design a well-balanced architecture and to deliver the design for an ARM based SoC or SoP (System on Package) capable of providing pre-exascale performance when implemented in the time frame of 2019-2020. The predicted performance target must be measured using real HPC applications.
2. To maximise the benefit for HPC applications with new high-performance ARM processors and throughput-oriented compute accelerators designed to work together within the well-balanced architecture .
3. To develop the necessary software ecosystem for the future SoC. This additional objective is important to maximize the impact of the project and make sure that this ARM architecture path will be successful in the market.
 
The project shall build upon the previous Mont-Blanc  & Mont-Blanc 2 FP7 projects, with ARM, BSC & Bull being involved in Mont-Blanc 1, 2 and 3 projects. It will adopt a co-design approach to make sure that the hardware and system innovations are readily translated into benefits for HPC applications. This approach shall integrate architecture work (WP3 & 4 - on balanced architecture and computing efficiency) together with a simulation work (to feed and validate the architecture studies )  and work on the needed software ecosystem.
Energy saving potential of pipe-embedded building envelope utilizing low-temperature hot water in the heating season

Abstract An active pipe-embedded building envelope has been verified to be effective for reducing heat transfer through building envelopes in summer. To decrease the energy consumption of heating, air source heat pumps are proposed for generating low-temperature hot water for the pipe-embedded building envelope in this study. A comprehensive numerical model is adopted to simulate the dynamic heat transfer in the pipe-embedded structure, and the model has been validated by experiment. The energy consumption and operation cost of the novel system are analyzed for different water temperatures. The seasonal performance in different cities and orientations is evaluated in winter conditions. The results show that 84% of the heat transfer on the internal surface can be reduced, whereas the heat dissipation on the external surface is increased by only 18% in Beijing. The proposed system is more suitable for cold regions because more heat transfer can be reduced there. The reduction ratios of the pipe-embedded system are close for all of the orientations, but the reduction amount on the north is 40% more than that on the south. The water temperature has a significant impact on the performance of the system, and room temperature water is suggested. Overall, the proposed system is effective as an auxiliary heating system.
ADH1B Arg47His Polymorphism Is Associated with Esophageal Cancer Risk in High-Incidence Asian Population: Evidence from a Meta-Analysis

Incidence of Esophageal squamous cell carcinoma (ESCC) is prevalent in Asian populations, especially in the ones from the "Asian esophageal cancer belt" along the Silk Road and the ones from East Asia (including Japan). Silk Road and Eastern Asia population genetics are relevant to the ancient population migration from central China. The Arg47His (rs1229984) polymorphism of ADH1B is the highest in East Asians, and ancient migrations along the Silk Road were thought to be contributive to a frequent ADH1B*47His allele in Central Asians. This polymorphism was identified as responsible for susceptibility in the first large-scale genome-wide association study of ESCC and that's explained by its modulation of alcohol oxidization capability. To investigate the association of ADH1B Arg47His with ESCC in Asian populations under a common ancestry scenario of the susceptibility loci, we combined all available studies into a meta-analysis.A dataset composed of 4,220 cases and 8,946 controls from twelve studies of Asian populations was analyzed for ADH1B Arg47His association with ESCC and its interactions with alcohol drinking and ALDH2 Glu504Lys. Heterogeneity among studies and their publication bias were also tested.The ADH1B*47Arg allele was found to be associated to increased risk of ESCC, with the odds ratios (OR) being 1.62 (95% CI: 1.49-1.76) and 3.86 (2.96-5.03) for the His/Arg and the Arg/Arg genotypes, respectively. When compared with the His/His genotype of non-drinkers, the Arg/Arg genotype can interact with alcohol drinking and greatly increase the risk of ESCC (OR = 20.69, 95%CI: 5.09-84.13). Statistical tests also showed gene-gene interaction of ADH1B Arg+ with ALDH2 Lys+ can bring more risk to ESCC (OR = 13.46, 95% CI: 2.32-78.07).Revealed by this meta-analysis, ADH1B*47Arg as a common ancestral allele can significantly increase the risk of ESCC in Asians, especially when coupled with alcohol drinking or the ALDH2*504Lys allele.
Media warfare and the discourse of islamic revival: the case of the islamic state (is)

This proposal seeks to better our understanding of how Islamist movements use Social Media to reinforce their discourses, ideologies and thoughts during times of conflict, i.e. ideological levels of struggle. In brief, this study takes as its mission the task of unravelling patterns of rhetorical propaganda employed by the Islamic State (IS) and how this movement attracts individuals from all over the world and influences security in Europe and the world. There are two overlapping discourses which dialectically feed into each other: those of religious revival and political emancipation. By means of these discourses, IS reworks foundational myths and traditional religious symbols to appropriate an imagined past in a highly charged political and conflict-ridden context as a part of the solution to its beleaguered spirituality.

This proposal suggests employing interdisciplinary methods: critical discourse analysis (CDA), Corpus Linguistics, visual content analysis and multi-modal analysis. This aims to examine discourse, content and visual frames. The sample is supposed to include all YouTube video clips published by IS and the commentaries associated with these clips in English and Arabic. 

The importance of this project lies in understanding the socio-political and cultural-religious dimensions of the conflict and the ensemble of discourses that frame Islamic fundamentalism in general, and IS in particular, as well as how IS persuades recruits from the EU and worldwide. This project is significant in opening a new academic career path for me and in giving me an opportunity to apply for professorship/senior lecturer and chair positions in media and communication, sociolinguistics and discourse of Islamist movements in future.
WIPER BLADE

A washer apparatus 50 is provided to a coupling portion CN between a blade rubber 20 and a holder member 30, and has a length in a longitudinal direction of the blade rubber 20, which is set to be shorter than that of the blade rubber 20 in the longitudinal direction, and inner-peripheral-side-oriented injection nozzles 53a and 55a and an outer-peripheral-side-oriented injection nozzle 54a have openings oriented to respective ends of the blade rubber 20 in the longitudinal direction.
Methods and kits using a molecular interaction between a Smurf-1 WW domain and LIM mineralization protein isoforms

The instant application provides kits and methods for identifying agents which induce or inhibit the osteogenic effect of LMP or BMP proteins. The kits are directed to methods which measure either an amount of a complex between a Smurf protein or a fragment thereof and an LMP protein or a fragment thereof. Alternatively, the kits are directed to methods of measuring an amount of the ubiquitinated Smad protein or a fragment thereof.
Influence of separated vortex on aerodynamic noise of an airfoil blade

In order to clarify the mechanism by which aerodynamic noise is generated from separated flow around an airfoil blade, the relation between the attack angle and the aerodynamic noise of the blade was analyzed using a wind tunnel experiment and a CFD code. In the case of rear surface separation, the separated vortex which has a large-scale structure in the direction of the blade chord is transformed into a structure that concentrates at the trailing edge with an increase in the attack angle. The aerodynamic noise level then becomes small according to the vortex scale in the blade chord. When the flow is separated at the leading edge, a separated vortex of low pressure is formed at the vicinity of the trailing edge. The pressure fluctuations on the blade surface at the vicinity of the trailing edge become large due to the vortex in the wake. It is considered that the aerodynamic noise level increases when the flow is separated at the leading edge because the separated vortex is causing the fluctuations due to wake vortex shedding.
Use of Tumor Necrosis Factor–alpha-coated Gold Nanoparticles to Enhance Radiofrequency Ablation in a Translational Model of Renal Tumors

Radiofrequency ablation (RFA) has been most effective when the tumors are small, exophytic, and away from vital structures. We enlarged the size of the ablation kill zone by infusing a 30-nm tumor necrosis factor-alpha and polyethylene glycol-coated gold nanoparticle (CYT-6091, CytImmune Sciences, Inc.) before ablation in a rabbit kidney tumor model.A total of 37 New Zealand White rabbits had VX-2 tumors implanted into their bilateral kidneys; they were then split into 3 treatment groups of 10 rabbits each and a sham group of 7 rabbits as follows: (1) CYT-6091 only, (2) RFA only, (3) CYT-6091 followed 4 hours later by RFA. Gross and microscopic measurements of the ablation size as well as histologic analysis using hematoxylin and eosin staining were performed to determine the effect of CYT-6091 on the ablation.The RFA + CYT-6091 group had a larger zone of complete cell death than the RFA-only group when measured on microscopic examination (0.30 +/- 0.07 vs 0.23 +/- 0.03 mL, P = .03). The zone of partially ablated tissue was smaller in the RFA + CYT-6091 group than in the RFA-only group (0.08 +/- 0.02 vs 0.13 +/- 0.05 mL, P = .01).We have demonstrated the efficacy of CYT-6091 in enhancing RFA in a translational kidney tumor model. The potential usage of CYT-6091 to improve RFA of renal cell carcinoma merits further study.
5-AMINOINDENO(1,2-C)PYRAZOL-4-ONES AS ANTI-CANCER AND ANTI-PROLIFERATIVE AGENTS

The present invention relates to the synthesis of a new class of indeno [1,2-c]pyrazol-4-ones of formula (I), that are potent inhibitors of the class of enzymes known as cyclin dependent kinases, which relate to the catalytic subunits cdk1-7 and their regulatory subunits known as cyclines A-G. This invention also provides a novel method of treating cancer or other proliferative diseases by administering a therapeutically effective amount of one of these compounds or a pharmaceutically acceptable salt form thereof. Alternatively, one can treat cancer or other proliferative diseases by administering a therapeutically effective combination of one of the compounds of the present invention and one or more other known anti-cancer or anti-proliferative agents.
Morphological Properties and Breakage Behavior of Three Ground Biofeedstocks by Hammermilling

Size reduction is one of the most important first steps during processing of biofeedstocks for food, feed, fuel, or fiber production. Size reduction improves conversion processes because of the creation of larger reactive surface areas, and it is also used to improve material handling in the process. This study investigated the particle size, particle size distribution, and morphological changes of three biofeedstocks (switchgrass, corn kernels, and soybean seeds) ground by hammermilling through three screen sizes (6.4 mm, 3.2 mm, and 1.6 mm). Feedstock particle size was analyzed based on both screen size and feedstock type. Significant differences were found among screen sizes; however, particle size differences among feedstock types were only significant for material passing through 6.4 mm and 3.2 mm screens. Of the three feedstocks, ground corn exhibited the smallest particle size as expressed by its geometric mean diameter (dwg), while soybean seeds exhibited the largest dwg. The morphological features of all the feedstocks, expressed as circularity, roundness, and aspect ratio, did not change significantly, as was initially hypothesized. While ground switchgrass had very high aspect ratios (10 to 12) and low circularity (0.20) and roundness (0.10), the opposite was seen for ground corn and soybean, which exhibited more spherical particles. It was concluded that the breakage behavior of biofeedstocks is an inherent material property that changes very little with size reduction by hammermilling.