SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Dyskeratosis Congenita- Management and Review of Complications: A Case Report

Among the inherited bone marrow failure disorders, dyskeratosis congenita is an X-linked inherited disorder arising as a consequence of short telomere and mutations in telomere biology. Production of the altered protein dyskerin, leads to vulnerable skin, nails, and teeth which lead to higher permeability for noxious agents which can induce carcinogenesis accounting for the classical triad of skin pigmentation, nail dystrophy and oral leukoplakia. This condition is fatal and patients succumb to aplastic anemia, malignancy or immunocompromised state. We present a young male with the classic clinical triad and avascular necrosis of both femoral heads, with no evidence of hematologic anomaly or any malignancy. He was managed for osteonecrosis with uncemented total hip arthroplasty for the symptomatic left hip. Our case represents a benign form of such a fatal and rare condition, which if detected and managed early can result in improved quality of life for the patient suffering from this disorder. This patient is under our meticulous follow-up for the last 2 years in order to determine any late development of complications before being labelled as a variant of this syndrome.
Macrophages skew towards M1 profile through reduced CD163 expression in symptomatic apical periodontitis

To explore the macrophage profiles in symptomatic and asymptomatic forms of AP through phenotypic and functional analyses. Cross-sectional study. Apical tissue/lesion samples were collected from patients with clinical diagnosis of AAP (n = 51) or SAP (n = 45) and healthy periodontal ligament (HPL) from healthy patients as controls (n = 14), all with indication of tooth extraction. Samples were digested, cells were stained for CD14, M1 (CD64, CD80), and M2 (CD163, CD206) phenotypic surface markers and analyzed by flow cytometry. Functional cytokine profiles L-6, IL-12, TNF-α, IL-23 (M1), IL-10, and TGF-β (M2) were determined by qPCR. Higher macrophage M1/M2 ratio (CD64+CD80+/CD163+CD206+) along with lower CD163 mean fluorescence intensity (MFI) were found in SAP compared to AAP and controls (p < 0.05). IL-6, IL-12, TNF-α, IL-23 (M1), and IL-10 mRNA (M2) were upregulated, whereas TGF-β mRNA (M2) was downregulated in apical lesions compared to controls. Specifically, IL-6 and IL-23 (M1) were upregulated in SAP compared with AAP and controls (p < 0.05). The data were analyzed with Kruskal-Wallis test. Macrophages exhibited a polarization switch towards M1 in AL. SAP exhibited a reduced M2 differentiation profile based on a reduction of CD163 expression levels in SAP over AAP. Specifically, IL-6 and IL-23 were augmented SAP over AAP, suggesting a role in the severity of apical lesions. Deciphering the macrophage polarization and functions in apical periodontitis can contribute to explain AP dynamics, its clinical presentation and systemic impact.
Realising value from electricity markets with local smart electric thermal storage technology

RealValue aims to demonstrate how local small-scale energy storage, optimised with advanced ICT, could bring benefits to market participants throughout the EU. Smart Electric Thermal Storage (SETS) will be deployed in physical demonstration trials in 1250 homes in Germany, Latvia and Ireland but the analysis will also consider other storage technologies and energy vectors, including integration with district heating and micro-generation.  SETS is a direct replacement for existing electric thermal storage heaters and water tanks with a combined load of 55GW across the EU. It can also replace direct electric resistance heaters with further connected load of 93GW. To validate the physical demonstrations at large scale RealValue will use modelling & virtual simulation to demonstrate the technical and commercial potential in millions of homes across representative EU regions. Thorough research studies are an integral part of RealValue and will include techno-economic and behavioural analysis that will be used to inform EU regulation and policy decision makers. RealValue will develop business models which quantify the potential of small-scale storage as an aggregated controllable load. It will provide system services or release value through price arbitrage within existing energy market structures, and highlight any barriers associated with integration into the electricity grid. The RealValue consortium is a truly cohesive partnership which has full participation and commitment from the whole energy supply chain. The consortium includes: technology developers (Glen Dimplex, Intel); energy system modelling specialists (UCD, DIW, RTU); energy market specialists (VTT); socio-economic experts (Oxford University); electricity network operators (ESBN, EirGrid) and energy utilities (MVV, SSE). RealValue is designed to accelerate innovation and develop business models necessary for small-scale storage, allowing it to form an integral part of the future EU energy landscape.
STRATEGIA D’IMPRESA IN SETTORI DI NICCHIA PER L’ECONOMIA AGROINDUSTRIALE DEL MEDITERRANEO

The project PYRGI aims at developing niche sectors of the rural economy and agro-industrial North of the Mediterranean through:
1. the exploitation of wild plants and cultivated multifunctional typical of the 'Mediterranean environment, or naturalized in it;
2. the strengthening of the economic chain that goes from the producer and the consumer ends with passing through the transformation, promotion and marketing of products identified and obtained.
Project activities include:
• domestication of new species;
• identification and exploitation of species and ecotypes of species already present in the area (eg herbs and Mediterranean);
• the study and implementation of strategies for bidding;
• characterization and promotion of species already cultivated (eg citrus courses, Genoese basil, Sardinian myrtle and some aromatic species to ornamental use such as rosemary, thyme and sage) as a symbol and representation of the territory;
• reduction of energy inputs (water, fertilizers, pesticides) through the use of low-species and selections needs;
• the study of the effect of cultivation techniques, the environment and its changes on the synthesis of secondary compounds and aromatic;
• the promotion of products derived from these species through the activation of dies for the exploitation of agro-industrial and commercial value of their characteristics (including the production of aromatic compounds in value, medicinal and nutraceutical) and the final marketing;
• the involvement of institutions that deal with promotion and enhancement of products, agricultural and processing enterprises, institutions or companies working in areas related to agriculture, the protection and enhancement of natural resources;
• the communication to the consumer and to promote their products. It will involve the system of rural houses, farms and pharmacy education.
CASE MEDITERRANEE

The project aims at promoting the Mediterranean Homes energy saving and sustainable buildings while the recovery of Mediterranean historic towns by encouraging experimentation and the use of materials and energy-efficient construction techniques - both traditional and modern - that are compatible with and respect the traditions of heritage and any constraints to its protection.
An initial identification phase of construction techniques, regulatory issues and present - coordinated by a technical committee Scientific transnational - will produce a series of guidelines that will flow into the building regulations of the municipalities concerned.
A second phase will be the implementation of 5 pilot sites with educational and demonstrative character. These sites, conducted by technical / expert teachers, it will have a double meaning: to apply and test one or more of the energy-saving technologies previously identified and at the same time designers and craftsmen are able to form, then, to propose such solutions in other contexts.
Study visits will be organized in parallel between the different sites and information days / training for designers and craftsmen of the area of ​​maritime cooperation Italy-France sometimes the transfer and exchange of know-how, technical / scientific. The sites also allow you to collect multimedia content (DVD, slides, etc..) Which will be converted into teaching modules to be used, not only for the training of other operators in the construction industry, but also for the dissemination of energy-saving solutions to the general public.
The ultimate goal of the project is the creation of a permanent network of Commons partners from other municipalities to expand the transnational maritime territory, for the updating and further development of issues related to the theme of energy saving and more specifically in the context of the Mediterranean bioclimatic houses
The influence of processed meat consumption on chronic obstructive pulmonary disease

Although cigarette smoking is the predominant risk factor for chronic obstructive pulmonary disease (COPD), many smokers do not develop COPD. Relatively little attention has been paid to other modifiable factors, such as diet, and how they might affect COPD risk. Recent studies have suggested that processed meat intake may adversely affect lung function and increase risk of developing COPD. However, the role of processed meat in the pathogenesis of COPD is largely unknown and mechanistic studies are lacking. We discuss several areas of future research that would advance our understanding regarding the role of processed meat and, more generally of diet, in the onset and in the clinical evolution of COPD.
Measures of Entropy and Change Point Analysis as Predictors of Post-Surgical Adverse Outcomes

A variety of adverse outcomes, such as kidney injury, death, cardiac injury, and respiratory failure affect a significant number of patients after surgery. Previous research has investigated possible predictors for these outcomes including features extracted from physiologic time series. This study builds upon this previous work by exploring entropy, long-term memory, and change point analysis as different and possibly predictive measures of volatility. To do this, we use both random forest models and the robust method of L1 regularized logistic regression as modeling frameworks for the prediction. Predictive results from these models are evaluated using receiver operating characteristic (ROC) curves and their area under the curve (AUC) values. While the developed models did not show improvements in predictive accuracy, they did show that change point analysis and measures of entropy and long-term memory can be useful tools in predicting postsurgical adverse outcomes.
University of Malaya Dental Students’ Perception on Competency Based Test

This study was undertaken to explore the perception of Year IV and Year V University of Malaya dental students on different domains related to the competency based test (CBT). Methodology: A questionnaire was constructed and a survey conducted to explore the students’ perception on four domains related to the competency test: 1) benefits, 2) readiness to take, 3) timing and 4) lecturers’ supervision. Results: In general, majority of the students agreed that they benefited from the competency test and felt adequately prepared for each test. Students’ agreeing on feeling confident to sit for each test ranged from 70.0%- 81.4% for Year IV and 45.1%-70.4% for Year V. Majority of Year IV and Year V students perceived that the timing of each competency test was ‘just right’. There was a high response of ‘Strongly agree/agree’ to availability of patients for practice and assessment, self-confidence and amount and distribution of clinical session as factors affecting when they take the CBT. Majority of Year IV students agreed that the assessment of lecturers was consistent for each tests while Year V had a high percentage of ‘Neutral’ response. Students’ agreeing that there was feedback after the test was 52.9%-71.4% for Year IV and 31.0%-56.5% for Year V. ‘Strongly agree/agree’ response of 68.6%-75.0% for Year IV and 36.6%-52.1% for Year V was recorded for the level of supervision being the same after passing the test. Conclusion: Overall, majority of students gave positive perception towards CBT in relation to four main domains explored in this research.
The Influence of Electromagnetic Interference on the Hydro-turbine Governor and Countermeasures

With the development of hydropower plant automation,intelligent demand continues to improve,more and more electrical control equipments enter hydropower plant,hydro-turbine governor as the core of turbine control equipment is facing a severe test in the increasingly complex electromagnetic environment Aiming at the electromagnetic interference problem of hydro-turbine governor of a hydropower plant meet,find by hard and thorough search analyzes the electromagnetic interference source and transmission,and puts forward some practical and effective measures to solve.To improve the electromagnetic immunity of hydro-turbine governor,combined with the electric property and structure characteristics of hydro-turbine governing system,this paper specifically proposed EMC solution from 3 points of grounding,shielding and filtering.The hydro-turbine governors with the electromagnetic compatibility measures successfully passed the electromagnetic compatibility test(GB),and withstand several power plant practices running test,and provide reliable guarantee for safe operation of hydropower plant.
Incidence of Honeybee Virus and Nosema on Flowering Period of Acacia in 2013 of Korea

There are about 20 thousand beekeepers caring for approximately 1.8 million colonies in Korea. Honey production totaled almost 27 thousand M/T in 2012. Virus and nosema cause significant losses in honey production and decrease population size. We initiated a survey of honey bee colonies on blooming period of Acacia to determine the prevalence of virus and nosema in 2013. Forty eight hives owned by 16 beekeepers were sampled in this year. The six most important honeybee viruses were investigated by RT-PCR. Among them, four different viruses were detected in samples. BQCV and SBV were present in samples from all. Prevalence of IAPV was 31%. KBV were present in only 6% of the samples. However, CBPV and DWV were not detected in any of samples. Nosema spore counts ranged from zero to 1.94 million spores per bee. The average number of nosema spores per bee was 425,000. Approximately 94% of colonies were infected with nosema based on the presence of spores in flowering period of Acacia. It illustrated that nosema, and BQCV and SBV in virus were the predominant species affecting honeybee colonies.
Topological effects in bosonic lattices

Controlling and manipulating quantum matter is a fast-growing research topic that could revolutionise technology and influence many aspects of our daily life. A promising step in this direction is to use topological concepts to tune physical properties of matter and to exploit novel phenomena useful to build new physical devices. In the last decade, topology have been extensively studied in the context of quantum many-body systems, a revolution that has led to the discovery of the topological insulators. Similarly, the Fubini-Study metric has just begun to show its physical meaning and role played in some quantum phenomena, but a lot more remains to be investigated. In this Action, I will study how topological and geometrical effects emerge in the physics of bosons in lattices. I will first address the geometrical contribution in the dynamics of two-body bound states, and then I shall identify conditions for enhancing inter-particle interactions on a full many-body system. I will apply these findings on photonic lattice systems and investigate how non-trivial quantum geometry and topology can lead to novel lasing phenomena. The nature of the work, being based on a combination of expertise, will have a strong interdisciplinary character. The research will be done at Aalto University in the Quantum Dynamics group led by Academy Professor Päivi Törmä, with the unique and exciting opportunity for me to work on the theory in a side by side collaboration with the experimentalists of the group. The expected impact of this research will advance our understanding of the topological properties of bosons in lattices, towards the exploration of geometrically-induced ultrafast lasers and strongly correlated topological fluids of light.
Stretchable mesh-electrodes interfacing human ipsc brain organoids

Recent advances in cellular engineering allow to recruit skin cells from donors and reprogram them into neural stem cells. These induced pluripotent stem cells (iPSC) bear the genetic code of the human patient. Efforts to culture these cells in-vitro have been successful in creating a wide variety of 3D arrangements called neurospheres. Because the human central nervous system is by and large inaccessible at all developmental stages, these functional tissue preparations are invaluable. Furthermore, clinical studies performed in animal models are known to translate poorly to humans and therefore these systems provide unprecedented advantages: human neurons in a controlled environment that have the genetic signature of psychiatric or mental disorders borne by the donor patient, such as Alzheimer’s or Parkinson’s disease. Finally, compared to animal studies where overwhelmingly only male animals are studied, stem cell research can operate on both sexes.
The combination of new biomaterials, genome engineering and massively parallel single-cell transcriptomics opens opportunities to precisely study human brain disease
A new exciting development is the possibility to form so-called assembloids, whereby organoids of different brain regions, as for example cortical and thalamic neural ensembles, are brought in proximity and self-assemble into anatomically correct brain regions. These approaches are necessary to study disorders like epilepsy. However these cultures lack physiological sensory input which are key in the development of mental plasticity. Here we plan to overcome this limitation by integrating new mesh-based electrodes that integrate seamlessly into brain tissue and expand symbiotically with the neurosphere as it grows, and thereby have a spatially refined mean to measure but also elicit neural activity. This will shed light on how electric maturation of these neurospheres comes about and help shape them to an anatomically more faithful brain model.
Adaptación a las nuevas condiciones de distanciamiento físico e higiene en el contexto de la pandemia de COVID-19

Aislamiento físico de los espacios de trabajo y consumo, permitiendo la separación efectiva entre empleados y clientes, e instalación de dispensadores automáticos de alcohol en gel en la entrada del sitio (consumible para desinfección durante 6 meses), así como desinfección obligatoria, a través de cinturones específicos, de calzado a la entrada y salida. Compra de guantes, máscaras y viseras por un período
Researchers for humanity 2018-2019

“Researchers for Humanity 2018-2019” will continue the series of events already organized in Romania from 2007, building a strong link between public and research through this important message of relevance: what science and researchers do are useful for daily life, and their life is as everyone’s elses.   For one day (or 2 days in some places), the public will have the chance to meet important players from science and education through play, interesting talks and interactive hands-on learning. Overall, the message conveyed will be how science can be used in the benefit of humanity.   Based on the outstanding awareness of the European dimension of the event that we created throughout the years, Researchers Night 2018-2019 will confirm as being one of the most important communication event for research and education institutions.   The network increased year after year, so that, now, the event itself will be organized in 21 big, medium and small cities from all over Romania.  Also, through the platform, we will invite associated events to get enrolled and be supported by us through promotion at the national level.    We aim to reach 52000 visitors, over 350 researchers, students and teachers and over 600000 prs to be exposed to the awareness campaign.   The logo will assemble with the old one in order to create a link with previous years and awareness of the European and national dimension of the event.  Partnerships will be continued at national and local level (also with one of the most important TV stations in Romania). The main novelty of the project will be the component of private research through private companies and NGOs that are implementing various research projects.
Note on the Budget of the European Union and an Internet Communication Tax

The European Union (EU) wants to finance part of the EU budget with a European tax which citizens would pay directly to the Union. One option is a communication tax. After a brief view of the finances of the EU and the history of the idea of taxing communication, the note states the criteria used in selecting a EU tax. After an assessment according to the criteria, the article concludes that at this moment a European Internet communication tax is not a viable option. For the citizen, it is a visible and equitable tax that does not distort economic decision-making. However, it makes hardly any sense from the point of view of the other budgetary, efficiency, and political criteria. To reform this situation, an EU policy on information and communication technologies is planned, including the dedication of resources to an EU-wide infrastructure and digital networks, which could make taxation of communications at the EU level a more feasible option. However, the technical aspects of taxing the Internet and other media — which are, at present, hardly discussed — may still prove to be significant barriers to such a policy.
MEDiteranean CYcle route for sustainable coastal TOURism

Sparkling emerald seas, kilometres of golden sand, wonderful food and ancient cities…it’s not hard to find reasons to go cycling along the Mediterranean! Unfortunately, in the 8 countries covered by this project, the potential of cycling tourism has not yet been realised even though it prolongs the tourism season, reduces the environmental impact of travelling and can bring tourists to less visited areas.
EuroVelo 8 – Mediterranean Route is a long-distance cycle route that connects the whole Mediterranean from Cyprus to Cádiz. The overall objective of the project is to use this route as a tool to influence regional and national policies in favour of sustainable and responsible tourism, providing transnational solutions in coastal areas across the Mediterranean.  
The main outputs will be action plans and policy recommendations (to generate investments in the route conditions); pilot actions (to test the proposed developments); and updated information and promotion related to EuroVelo 8 (to attract visitors). In this way, the project will benefit national, regional and local authorities, service providers and, ultimately, cycle tourists. 
Taking a transnational approach will enable common challenges (e.g. lack of route infrastructure, missing cycling friendly services, weak branding and promotion) to be tackled together and best practices to be shared, thereby avoiding duplication and increasing the effectiveness and positive social, economic and environmental impacts.