SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
A clustering approach for the wind turbine micro siting problem through genetic algorithm

Offshore wind farms with high installed capacities and located further from the shore are starting to be built by northern European countries. Furthermore, it is expected that by 2020, several dozens of large offshore wind farms (LOWFs) will be built in the Baltic, Irish and North seas. These LOWFs will be constituted of a considerable amount of wind turbines (WTs) packed together. Due to shadowing effects between turbines, the power production is reduced, resulting in a decreased wind farm efficiency. Hence, when LOWFs are considered, wake losses reduction is an important optimization goal that needs to be considered. This work presents a clustering approach to optimize the energy production of LOWFs through a genetic algorithm (GA). The method consists of a turbine clustering strategy where the optimal wind farm layout is obtained in different steps. The number of turbines used in each step is increased until all turbine locations have been optimized. The results demonstrate the method effectiveness. A computational time decrease and a reduction of the problem search space are observed when compared to the standard optimization strategy, without jeopardizing the quality of the optimal layouts achieved.
Effects of tissue factor pathway inhibitor-2 on the growth and angiogenesis of subcutaneous tumor xenografts in nude mice established from human liver cancer cells

Objective: To investigate the effects of TFPI-2 (tissue factor pathway inhibitor 2) on the growth and angiogenesis of subcutaneous tumor xenografts in nude mice established from human liver cancer cells. Methods: The Hep3B cells stably expressing TFPI-2 (Hep3B-TFPI-2 group) and the Hep3B cells transfected with empty vector PCDNA3.1 (Hep3B-V group) or without transfection (Hep3B-P group) were subcutaneously transplanted into nude mice respectively to generate subcutaneous tumor xenografts. The volume of tumor xenograft was measured every three days, and the growth curve of tumor xenograft was drawn when the subcutaneous tumor xenograft was visible. The nude mice were killed three weeks after transplant, the volume of tumor xenograft was measured, and the total RNAs and proteins in tumor xenografts were extracted. The mRNA and protein expressions of TFPI-2 and VEGF (vascular endothelial growth factor) in tumor xenografts were analyzed by RFQ-PCR (real-time fluorescence quantitative PCR) and Western blotting, respectively. The expression of TFPI-2 protein and the MVD (microvessel density) in tumor xenografts were observed by immunohistochemistry. Results: The eventual tumor volume of tumor xenografts in Hep3B-TFPI-2 group was apparently smaller than those in Hep3B-V group and Hep3B-P group (both P < 0.05). The expression of mRNA and abundance of protein of TFPI-2 in Hep3B-TFPI-2 group were significantly higher than those in the other two groups (P < 0.05); while the expression of mRNA and abundance of protein of VEGF in Hep3B-TFPI-2 group were apparently lower than those in the other two groups. Compared with Hep3B-V group and Hep3B-P group, the inhibitory rates of VEGF protein expression in Hep3B-TFPI-2 group were 19.8% and 23.5%, respectively (P < 0.05). The MVD in Hep3B-TFPI-2 group was apparently lower than those in the other two groups (P < 0.05). Conclusion: TFPI-2 can significantly inhibit the growth and angiogenesis of subcutaneous tumor xenografts in nude mice established from hepatocarcinoma Hep3B cells. DOI:10.3781/j.issn.1000-7431.2013.02.009
USE-DEPENDENT INDICATOR SYSTEM FOR ABSORBENT ARTICLES

A use-dependent indicator system for detecting the exhaustion of an active chemical within an absorbent article is provided. The indicator system includes at least one dye component and a polymer mixture. The dye component(s) can be non-reactive and/or reactive dyes. The polymer mixture can contain a polymer, such as a latex adhesive, to facilitate control over the dissolution rate of the dye component(s). By controlling the dissolution rate of the dye component(s), an indicator system of the present invention can impart a change in color to signal the exhaustion of an active chemical incorporated within the absorbent article, such as an anti-microbial agent.
I FATTORI BIOMEDICI PER LA CERTIFICAZIONE ERGONOMICA DI PRODOTTO

LÂ¿ACQUISIZIONE DEI SERVIZI INNOVATIVI PER SVILUPPARE UNO STRUMENTO (SOFTWARE) CONSENTIRÃ  DI OTTIMIZZARE IN MODO DECISIVO LÂ¿OPERATIVITÃ  IN CAMPO VALUTATIVO PER OFFRIRE AI CLIENTI TUTTE LE INFORMAZIONI NECESSARIE PER MIGLIORARE IL PROCESSO DI PROGETTAZIONE DEI LORO PRODOTTI INTEGRANDO LE LORO CONOSCENZE TECNICHE CON LE BASILARI INFORMAZIONI ERGONOMICHE RELATIVE AL RAPPORTO DI INTERFACCIA TRA UTILIZZATORE E PRODOTTO UTILIZZATO
Turbulence in the Outer Heliosheath

We present in situ observations of magnetic turbulence in the draped interstellar magnetic field measured by Voyager 1 during an undisturbed interval from 2015.3987 to 2016.6759 confirming the existence of the turbulence observed previously from 2013.3593 to 2014.6373. The power spectral density of the turbulence was the same in both cases. The turbulence had a Kolmogorov k ?5/3 spectrum in the range from k?=?1.3?×?10?13 cm?1 to 4?×?10?12 cm?1. The ratio of the turbulent fluctuations to the average magnetic field strength was only 0.02, indicating that the turbulence was very weak. Extrapolating the power-law slope to lower frequencies yields an upper limit on the turbulence outer scale of 0.01 pc?=?2000 au, which may be regarded as the distance at which Voyager 1 will enter the undisturbed local interstellar medium, beyond the outer heliosheath or bow wave in the upstream direction. The maximum variance of the fluctuations was in the two directions transverse to the average magnetic field in the recent interval, whereas it was parallel to the average magnetic field in the earlier interval, suggesting a transformation from turbulence with a dominant compressive component to turbulence dominated by transverse fluctuations. As the magnitude of the fluctuations was approaching that of the uncertainties of the measurements, the latter result requires confirmation by further observations.
Self-Organization of the cilium: the role of the tubulin code

This project aims at understanding of the role of the tubulin code for self-organization of complex microtubule based structures. Cilia turn out to be the ideal structures for the proposed research.
A cilium is a sophisticated cellular machine that self-organizes from many protein complexes. It plays motility, sensory, and signaling roles in most eukaryotic cells, and its malfunction causes pathologies. The assembly of the cilium requires intraflagellar transport (IFT), a specialized bidirectional motility process that is mediated by adaptor proteins and direction specific molecular motors. Work from my lab shows that anterograde and retrograde IFT make exclusive use of the B-tubules and A-tubules, respectively. This insight answered a long standing question and shows that functional differentiation of tubules exists and is important for IFT.
Tubulin post-translational modifications (PTMs) contribute to a tubulin code, making microtubules suitable for specific functions. Mutation of tubulin-PTM enzymes can have dramatic effects on cilia function and assembly. However, we do not understand of the role of tubulin-PTMs in cilia. Therefore, I propose to address the hypotheses that the tubulin code contributes to regulating bidirectional IFT motility, and more generally, that the tubulin code is a key player in structuring complex cellular assembly processes in space and time.
This proposal aims at (i) understanding if tubulin-PTMs are necessary and/or sufficient to regulate the bidirectionality of IFT (ii) examining how the tubulin code regulates the assembly of cilia and (iii) generating a high-resolution atlas of tubulin-PTMs and their respective enzymes.
We will combine advanced techniques encompassing state-of-the-art cryo-electron tomography, biochemical imaging, fluorescent microscopy, and in vitro assays to achieve molecular and structural understanding of the role of the tubulin code in the self-organization of cilia and of microtubule based cellular structures.
Aquisição de tecnologia para empresas em fase de arranque

A recorrente é a Kovero-EU, que se dedica à produção e à soldadura de metais. A fim de melhorar a qualidade dos serviços prestados, adquire tecnologias que faltam no processo de produção e permitem ao requerente aumentar o número de novos clientes e encomendas. e.
SEMICONDUCTOR WAFER STRUCTURE

One embodiment provides a semiconductor wafer structure including a semiconductor wafer and a spacer layer. The semiconductor wafer includes active areas. The spacer layer is configured to provide spacing between the semiconductor dice in a stacked die package and the spacer layer is disposed on one side of the semiconductor wafer.
Disease burden and unmet needs for prevention of venous thromboembolism in medically ill patients in Europe show underutilisation of preventive therapies

Summary It was the aim of this review to assess the incidence of venous thromboembolism (VTE) and current practice patterns for VTE prophylaxis among medical patients with acute illness in Europe. A literature search was conducted on the epidemiology and prophylaxis practices of VTE prevention among adult patients treated in-hospital for major medical conditions. A total of 21 studies with European information published between 1999 and April 2010 were retrieved. Among patients hospitalised for an acute medical illness, the incidence of VTE varied between 3.65% (symptomatic only over 10.9 days) and 14.9% (asymptomatic and symptomatic over 14 days). While clinical guidelines recommend pharmacologic VTE prophylaxis for patients admitted to hospital with an acute medical illness who are bedridden, clear identification of specific risk groups who would benefit from VTE prophylaxis is lacking. In the majority of studies retrieved, prophylaxis was under-used among medical inpatients; 21% to 62% of all patients admitted to the hospital for acute medical illnesses did not receive VTE prophylaxis. Furthermore, among patients who did receive prophylaxis, a considerable proportion received medication that was not in accord with guidelines due to short duration, suboptimal dose, or inappropriate type of prophylaxis. In most cases, the duration of VTE prophylaxis did not exceed hospital stay, the mean duration of which varied between 5 and 11 days. In conclusion, despite demonstrated efficacy and established guidelines supporting VTE prophylaxis, utilisation rates and treatment duration remain suboptimal, leaving medical patients at continued risk for VTE. Improved guideline adherence and effective care delivery among the medically ill are stressed.
Hippo activation through homodimerization and membrane association for growth inhibition and organ size control

Hippo (Hpo) signaling plays a critical role in restricting tissue growth and organ size in both invertebrate and vertebrate animals. However, how the Hpo kinase is regulated during development has not been clearly understood. Using a Bimolecular Fluorescence Complementation assay, we have investigated the functional significance of Hpo homo-dimer formation and subcellular localization in living cells. We found that Hpo dimerization and membrane association are critical for its activation in growth inhibition. As dimerization facilitates Hpo to access its binding partner, Hpo kinases in the homo-dimer trans-phosphorylate each other to increase their enzymatic activity. Moreover, loss- and gain-of-function studies indicate that upstream regulators, Expanded, Merlin and Kibra, play a critical role in promoting Hpo dimerization as well as association to the cortical F-actin beneath the plasma membrane. Enforced Hpo localization to the plasma membrane increases Hpo dimerization and activity. Therefore, homo-dimerization and plasma membrane association are two important mechanisms for Hpo activation in growth control during animal development. ► Homo-dimerization of Hippo tumor suppressor is directly visualized in living cells. ► Hippo kinase trans-phosphorylates each other in the Hpo homo-dimer complex. ► Membrane localization facilitates Hippo dimerization, phosphorylation and activation. ► Merlin, Expanded and Kibra promote Hippo dimerization and membrane association.
Renewable solvents with high performance in application and improved toxicity profile

The primary aim of ReSolve is to replace the hazardous solvents toluene and N-methyl-2-pyrrolidone (NMP) with safe alternatives derived from non-food carbohydrates. Starting from promising bio-based platform molecules, an effective combination of computational modelling, high-throughput toxicity testing and evaluation of application performance will be used to design bespoke bio-based solvents. New structures will not contain the toxic aromatic or N-alkylamide functionalities that make toluene and NMP substances of very high concern. At least one primary apolar and one primary dipolar aprotic substitute for toluene and NMP respectively will be targeted. These solvents will be designed to serve a wide range of applications, will be brought to pilot-scale production at TRL 5. Their sustainability, low health impact and high application performance will also be demonstrated. The provision of safe and economically viable bio-based solvents by ReSolve will allow the full benefit of regulatory restrictions on the use of aromatic and nitrogen-containing solvents to be felt without a negative impact on the economic security of the European solvents industries. The impact of this research is also relevant to thousands of downstream businesses and consumers that are dependent on solvents. Above all, it will positively affect the health and safety of the millions of European citizens who are routinely exposed to solvents as part of their job. Additionally, ReSolve is set-up to produce a pipeline of new solvent candidates meaning that not only will a couple of candidates be taken to TRL 5, but many more candidates for specific applications will also be progressed to TRL 3-4, thus offering greater substitution options for hazardous solvents in the near future.
Vision-Dmd - phase 2 clinical trials of vbp15: an innovative steroid-like intervention on duchenne muscular dystrophy

VISION-DMD aims to advance clinical development of the orphan drug VBP15 as a new therapy to revolutionise care for all patients with Duchenne muscular dystrophy (DMD) by 2020, in line with IRDiRC goals. DMD is an incurable, rare muscle wasting disease; boys progressively weaken, lose ambulation and death occurs by early adulthood. Corticosteroids (CS) are widely recognised to increase muscle strength and delay disease progression but global acceptance as standard of care is very variable due to severe side effects. VBP15 is an innovative steroid-like drug designed to retain or better CS efficacy and improve membrane stabilization with reduced or no side effects. VBP15 will increase the therapeutic window to slow disease progression and improve quality of life and lifespan for all DMD patients. 
Building on positive preclinical and Phase 1 results funded by government grants and international patient groups and based on FDA and EMA advice, VISION-DMD proposes a Phase 2 registration directed clinical programme aimed at an affordable therapy: Phase 2a will study the safety and tolerability of ascending doses of VBP15 in ambulant DMD boys; Phase 2b will demonstrate the efficacy and safety of two doses of VBP15 in young ambulant DMD boys. Both studies will be followed by extension studies for long term safety and efficacy data collection leading to cumulative exposure of up to 2100 drug months. The project proposes the Time to Stand Test as a highly relevant and reliable primary endpoint. Innovative exploratory serum biomarkers and novel wide scale MRI techniques will be used to investigate the VBP15 pharmacodynamics and the effect on muscle cellular pathology. VBP15 will meet the unmet need for better treatment for DMD with widespread acceptance and potentially be used in combination with stratified therapies as they are developed. The Consortium links the leading networks TREAT-NMD and CINRG with ECRIN-ERIC, for trial delivery and regulatory undertakings in Europe/US
Nota de la 3.ª Edición del Simposio Internacional sobre Ambientes Extremos y Organismos Extremófilos (ISE3O). Universidad Autónoma de Santo Domingo, República Dominicana, 2022

No necesita un resumen.
Determinants of Capital Structure: An Empirical Analysis of Fuel and Energy Sector of Pakistan

This study was conducted to identify the factors that influence debt ratio in financing. In this study, we have targeted the firms of fuel and energy sector listed in Pakistan to analyze our results. The analysis is conducted for the period 2010 to 2015. After applying regression analysis, our results stated that profitability, size, tangibility have the positive association with leverage in this sector while tax rate results observed the negative relationship with advantage since the tax rate increases the debt financing declines. The overall results of this study supported trade-off theory of capital structure in fuel and energy sector of Pakistan.
Methods and apparatus for reducing frame violations in a stereoscopic display

Methods and apparatus are provided for reducing frame violations in a stereoscopic display. A stereoscopic display system for presenting a stereoscopic image to a user suitably includes one or more cameras, each providing a video image, and a video processor. A stereoscopic display includes a left module and a right module, with each module having an eyepiece and a display panel with at least one aperture located therebetween. The stereoscopic display is configured to produce the stereoscopic image on the display panels as a function of image data received from the video processor, with the apertures forming a window around at least a portion of the perimeter of the display to thereby provide a visual reference point to the user that reduces or eliminates frame violations. The stereoscopic display system may be used during aerial refueling operations, or in any other display environment.
Public Health Department Accreditation

Health department accreditation is one of the most important initiatives in the field of public health today. The Public Health Accreditation Board (PHAB) is establishing a voluntary accreditation system for more than 3000 state, tribal, territorial, and local health departments using domains, standards, and measures with which to evaluate public health department performance. In addition, public health department accreditation has a focus on continuous quality improvement to enhance capacity and performance of health departments in order to advance the health of the population. In the accreditation effort, a practice-based research agenda is essential to build the scientific base and advance public health department accreditation as well as health department effectiveness. This paper provides an overview of public health accreditation and identifies the research questions raised by this accreditation initiative, including how the research agenda will contribute to better understanding of processes underlying the delivery of services by public health departments and how voluntary accreditation may help improve performance of public health departments.
Resection of Degenerated Leiomyoma by Laparotomy during Second Trimester of Pregnancy with Favorable Outcome: A Case Report and Review of Literature Regarding Leiomyomas during Pregnancy

Aims: We present a case of degenerated leiomyoma in pregnancy causing pain that deteriorated with conservative management and was successfully treated with myomectomy. Presentation ofCase: A 37-year-old woman with a known asymptomatic subserosal leiomyoma was admitted to the obstetrics clinic of our hospital at the gestational age of 18+3 weeks due to gradually worsening constant right quadrant lower abdomi nal pain of acute onset. Clinical examination, laboratory investigation and abdominal ultrasonography led to the conclusion that the pain was due to the degeneration of the leiomyoma. The initial conservative approach was not effective so the subserous lei omyoma was resected by laparotomy. The pregnancy progressed normally until the delivery of a healthy neonate at 37+5 weeks gestational age by cesarean section due to the prior myomectomy. The
Soybean Variety XB29AA13

A novel soybean variety, designated XB29AA13 is provided. Also provided are the seeds of soybean variety XB29AA13, cells from soybean variety XB29AA13, plants of soybean XB29AA13, and plant parts of soybean variety XB29AA13. Methods provided include producing a soybean plant by crossing soybean variety XB29AA13 with another soybean plant, methods for introgressing a transgenic trait, a mutant trait, and/or a native trait into soybean variety XB29AA13, methods for producing other soybean varieties or plant parts derived from soybean variety XB29AA13, and methods of characterizing soybean variety XB29AA13. Soybean seed, cells, plants, germplasm, breeding lines, varieties, and plant parts produced by these methods and/or derived from soybean variety XB29AA13 are further provided.
Prediction of a body's structural impedance and scattering properties using correlation of random noise

This paper derives a method to estimate the structural or surface impedance matrix (or equivalently the inverse of the structural Green's function) for an elastic body by placing it in an encompassing and spatially random noise field and cross-correlating pressure and normal velocity measurements taken on its surface. A numerical experiment is presented that utilizes a cross-correlation method to determine the structural impedance matrix for an infinite cylindrical shell excited by a spatially random noise field. It is shown that the correlation method produces the exact analytic form of the structural impedance matrix. Furthermore, using standard impedance formulations of the scattered and incident pressure fields at the object surface that are based on the equivalent source method and using this estimated structural impedance, a prediction of the scattered acoustic field at any position outside of the object can be made for any given incident field. An example is presented for a point (line) source near a cylindrical shell and when compared with the analytical result, excellent agreement is found between the scattered fields at a radius close to the shell.
The Effect of an Integrative Skills Program on Developing Jordanian University Students' Achievement in English

This study aimed at investigating the effect of an integrative program, the effect of gender and the interaction between gender and the program on developing Jordanian university students’ achievement in English .The participants of the study were 122 university students. The study adopted a quasi-experimental design. The data were collected using an achievement test which was validated and its interscorer reliability was ensured. ANCOVA was used to analyze the students’ full degrees while MANCOVA was used to analyze their sub degrees of the test. The results revealed a significant difference between the adjusted mean scores of students’ achievement in the posttest and a significant difference between the adjusted means for the students’ achievement in the parts of the posttest.  The results showed no significant difference between the adjusted mean scores of students due to gender and the interaction between gender and the teaching method.  They also showed a significant difference between the means of the students’ achievement in structures due to the interaction between the teaching method and gender in favor of the male while there was no statistically significant effect in vocabulary and reading comprehension.