SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Heterologous Protein Expression

Heterologous protein expression has been the foundation of the industrial and pharmaceutical biotechnology industries over the past 30 years. There are a wide variety of production platforms now commercially available and an increasing number under development encompassing different host cells, expression systems, and methods for utilizing the genetic instructions, as well as bioprocessing strategies that take advantage of the particular combinations to maximize volumetric productivity and product quality. It is generally accepted that there is no single, universal heterologous expression system and bioprocess strategy that will work for all proteins and that each protein product needs to be considered individually, based on the specific protein product, unique quality specifications, and intended application. Here, we describe some of the different cell-based and cell-free protein expression platforms for bioreactor-based production of heterologous proteins, an overview of how they work and how they have been used, and the potential advantages and disadvantages when compared with alternative approaches.
Coronal Sealing Capacity of Temporary Restorative Materials in Pediatric Dentistry: A Comparative Study

ABSTRACT Aims The aim of this in vitro study is to compare the coronal microleakage of three common temporary restorative materials, namely Coltosol, Compoglass, and Zonalin, used in pediatric dentistry after endodontic treatment at different time intervals (1 week, 1, and 2 months) using dye penetration. Materials and methods Access cavities were prepared in 72 intact extracted premolar teeth. The samples were divided into three groups (n = 24) and filled with Coltosol, Compoglass, or Zonalin. After thermal cycling for 500 cycles (5–55°C), the teeth were immersed in 1% methylene blue dye at 37°C for 1 week (n = 8), 1 month (n = 8), and 2 months (n = 8). The samples were sectioned buccolingually, and the linear depth of dye penetration was measured using a stereomicroscope at 16 × magnification. The data were analyzed using Kruskal–Wallis test. Results There were no significant differences in the microleakage values of Coltosol and Zonalin or Zonalin and Compoglass groups at 1 week (p &gt; 0.05) or 1 month (p &gt; 0.05) intervals, but a significant difference was noted between Coltosol and Compoglass groups (p &lt; 0.01); Coltosol provided a more favorable coronal seal. No significant difference was found among the experimental groups at the 2-month interval (p &gt; 0.05). Conclusion At 1 week or 1 month of use, Coltosol showed better coronal seal. At 2 months, there was no significant difference apparent between the groups. A longer time lapse was associated with an increased likelihood of microleakage. How to cite this article Milani S, Seraj B, Heidari A, Mirdamadi A, Shahrabi M. Coronal Sealing Capacity of Temporary Restorative Materials in Pediatric Dentistry: A Comparative Study. Int J Clin Pediatr Dent 2017;10(2):115-118.
A distinct magnetic property of the inner penumbral boundary. II. Formation of a penumbra at the expense of a pore

Context. We recently presented evidence that stable umbra-penumbra boundaries are characterised by a distinct canonical value of the vertical component of the magnetic field, B stable ver . In order to trigger the formation of a penumbra, large inclinations in the magnetic field are necessary. In sunspots, the penumbra develops and establishes by colonising both umbral areas and granulation, that is, penumbral magneto-convection takes over in umbral regions with B ver B stable ver , as well as in granular convective areas. Eventually, a stable umbra-penumbra boundary settles at B stable ver . Aims. Here, we aim to study the development of a penumbra initiated at the boundary of a pore, where the penumbra colonises the entire pore ultimately. Methods. We have used Hinode/SOT G -band images to study the evolution of the penumbra. Hinode/SOT spectropolarimetric data were used to infer the magnetic field properties in the studied region. Results. The penumbra forms at the boundary of a pore located close to the polarity inversion line of NOAA 10960. As the penumbral bright grains protrude into the pore, the magnetic flux in the forming penumbra increases at the expense of the pore magnetic flux. Consequently, the pore disappears completely giving rise to an orphan penumbra. At all times, the vertical component of the magnetic field in the pore is smaller than B stable ver ≈ 1.8 kG. Conclusions. Our findings are in an agreement with the need of B stable ver for establishing a stable umbra-penumbra boundary: while B ver in the pore is smaller than B stable ver , the protrusion of penumbral grains into the pore area is not blocked, a stable pore-penumbra boundary does not establish, and the pore is fully overtaken by the penumbral magneto-convective mode. This scenario could also be one of the mechanisms giving rise to orphan penumbrae.
FIRE-BARRIER FILM LAMINATE

A fire-blocking paper (22, 52) is adapted for incorporation into a fire-barrier film laminate (16, 46) for use in thermal and acoustical insulation systems (10, 40), such as, but not limited to, those used in commercial aircraft. The fire-blocking inorganic fiber paper (22, 52) can be laminated to a flame resistant film (24a, 24b, 54a, 54b). The fire-blocking paper (22, 52) may include inorganic bio-soluble fiber, chopped glass non-respirable fibers, organic reinforcing fibers, organic binder, and inorganic binder or filler; and, optionally or refractory ceramic fibers.
Decoding the epigenetic signature of memory function in health and disease

The emerging field of neuroepigenetics investigates processes such as histone-acetylation in the context of
neuronal plasticity, memory function and brain diseases. My group has significantly contributed to this novel
research field. It is however fair to say that the role of “epigenetics” in memory function is still met with
some skepticism in the neurosciences, which is in part due to the fact that many of the current studies have
been describing phenomena and mechanistic data to explain how epigenetic processes control memory
function in health and disease are comparatively sparse. The major objective of this research proposal is to
address this issue and help to consolidate the field of neuroepigenetics by providing insight to the
mechanisms by which epigenetic processes contribute to memory formation under physiological and
pathological conditions. More specifically I will ask how the epigenetic code is translated into cellular
changes that mediate memory formation in health and disease and how can epigenetic mechanisms
contribute to the transmission of cognitive phenotypes even across generations. Our results will not only
provide import insight to the mechanisms that underlie memory formation but will also lay the basis for the
development of novel and improved therapies for age-related cognitive disorders.
Effects of multiple spreaders in community networks

Human contact networks exhibit the community structure. Understanding how such community structure affects the epidemic spreading could provide insights for preventing the spreading of epidemics between communities. In this paper, we explore the spreading of multiple spreaders in community networks. A network based on the clustering preferential mechanism is evolved, whose communities are detected by the Girvan–Newman (GN) algorithm. We investigate the spreading effectiveness by selecting the nodes as spreaders in the following ways: nodes with the largest degree in each community (community hubs), the same number of nodes with the largest degree from the global network (global large-degree) and randomly selected one node within each community (community random). The experimental results on the SIR model show that the spreading effectiveness based on the global large-degree and community hubs methods is the same in the early stage of the infection and the method of community random is the worst. However, when the infection rate exceeds the critical value, the global large-degree method embodies the worst spreading effectiveness. Furthermore, the discrepancy of effectiveness for the three methods will decrease as the infection rate increases. Therefore, we should immunize the hubs in each community rather than those hubs in the global network to prevent the outbreak of epidemics.
CHIRAL FERROCENYLS

The invention relates to chiral ferrocenyls of formula (I), wherein Ra is -P(R10R11) or -SR12; Rb is -P(R'10R'11), -SR'12, -CH=NR12, -CH2-NH-R12 or -CH2-O-P(R10R11); and the other substituents are as defined in claim 1, which may be used as ligands for transition metal catalysts in enantioselective reactions.
Do the<i>DSM-5</i>diagnostic revisions affect the psychometric properties of the Brief Biosocial Gambling Screen?

Several significant changes in the diagnostic criteria for gambling disorder occurred with the newest revision of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5). The changes aim to simplify and streamline the diagnosis without compromising its validity. Yet many of the tools used to screen and diagnose the disorder are based upon the prior fourth edition of the DSM, and it is unclear how they perform with the revised diagnostic criteria. The aim of this study is to examine the psychometric properties of a common pathological gambling screen, the Brief Biosocial Gambling Screen (BBGS; Gebauer, LaBrie, & Shaffer, 2010), in the context of DSM-5 criteria within a help-seeking sample. Gamblers calling a helpline (N = 2750) completed a semi-structured interview assessing DSM-IV past-year pathological gambling criteria with a trained clinician. Sensitivity, specificity, positive predictive value, negative predictive value and differences by sex were examined. The BBGS had high sensitivity as w...
Elevvo: a ground-breaking wearable brain-computer interface that enables self-management of cognitive welfare through personalised training exercises

Cognitive decline (progressive loss of mental cognitive abilities) is a natural event that affects us all after the age of 40. Although age is a main factor, low-demanding brain activity can speed up the process & end up in cognitive impairment, which is a major cause of disability worldwide. Importantly, the onset & progress of cognitive decline can be hindered with preventive training that stimulates cognitive abilities. This realization is driving the market of cognitive training, foreseeing a $7.5 billion turnover and 83% population adoption by 2020. This growth will be mostly driven by the revolution of wearables & biometric technologies, which are increasing rapidly as people become more prone to manage their own health. However, current market offerings for brain training either need the presence of a clinical specialist or lack any scientific relevance. In response, we at BitBrain Technologies have developed ELEVVO, a ground-breaking neuro-wearable technology that enables self-management of cognitive welfare and yields real measurable enhancement. ELEVVO uses a gaming approach to train cognitive-related patterns, relying on intelligent big-data mining to automatically tailor the challenges to the users’ brain rhythms and to measure the progress achieved. Importantly, ELEVVO will be the only scientifically-validated product for cognitive training in the mass market. Indeed, we have proved the ELEVVO’s efficiency in healthy adults (students, workers, elderly) and in neuropathology cases. Altogether, with this project we aim to finalise the development of ELEVVO and to scale-up our deployment capability. The Feasibility Study planned in Phase 1 will help us warrant the project from all technical, commercial & financial standpoints. Upon completion, ELEVVO will bring a major social & economic impact to society, enhancing life-quality & well-being. In turn, it will boost the growth of our company, projecting a R..
UiTM Share Ride: Requirements Validation, Design and Development of a Campus Ride-Sharing Mobile Application

The excessive number of cars entering university campus and limitation of parking areas have resulted in difficulty of finding parking spaces for many university staff and students. It is a typical issue occurring in most of university campuses all around the world. Carpooling or ride-sharing is viewed as the practical approach to solve this problem. The suggestion to share rides will lessen the amount of vehicles entering university campuses thus reducing parking space problem and decrease fuel emission for a cleaner and healthier environment. Thus, development of a campus ride-sharing mobile application will be a good medium for university staff and students to share their rides and solve this pressing issue in many campuses. This research has attempted to validate the system requirements for UiTM Share Ride mobile application, followed by designing and developing the mobile application using Android platform for UiTM’s staff and students. Four phases have been undertaken in order to complete the research, which are preliminary study, requirements validation, user design, and followed by application construction. The outcome is a UiTM Share Ride mobile application, which can manage ride sharing requests among passengers and drivers in UiTM communities that will eventually solve the issue of congestion in the university campus.
ARBEITEN SIE RUND UM DIE UHR. PERSONALISIERTE WEBBASIERTE PLATTFORM FÜR ONLINE-BERATUNG UND FERNUNTERRICHT

KONZEPTION UND UMSETZUNG EINER PERSONALISIERTEN WEBBASIERTEN PLATTFORM FÜR ONLINE-BERATUNG UND FERNUNTERRICHT FÜR BENACHTEILIGTE MENSCHEN.
Die intermediale Darstellung der Migration über das Mittelmeer in der Graphic Novel Liebe deinen Nächsten von G. von Borstel und P. Eickmeyer

Das Schicksal der Flüchtlinge auf ihrem Weg über das Mittelmeer wird in Liebe deinen Nächsten (2017) lebhaft gezeigt, in dem Gaby von Borstel und Peter Eickmeyer ihre dreiwöchige Erfahrung auf einem Rettungsschiff wiedergeben. Die Spannung zwischen Sprache, Schrift und Bild, der wechselnde Gehalt des Pronomens ‚wir‘ und des Substantivs ‚Meer‘, die entscheidende Rolle des Erzählens, das Zusammenspiel zwischen dem Buch und dem Blog der Autoren, der praktische Nutzen des Bandes für eine Spendenaktion sind einige bedeutende Aspekte dieser Graphic Novel, die zeigen, wie vielseitig und kraftvoll die Darstellung der „fragmentierten Flucht nach Europa“ (B. Etzold) ist, die Liebe deinen Nächsten dem Leser anbietet.
Pericyte-Derived tumor stroma – a target for cancer therapy

Cancer is a devastating diagnosis since treatments to prevent a lethal outcome are limited. Tumor constitutes a complex tissue consisting of malignant cells and stromal cells. Emerging studies have shown the importance of stroma in tumor growth, invasion, and metastasis highlighting its potential as an attractive target for cancer therapy. However, the source of tumor stroma generating cells remains elusive. Generation of connective tissue is a general feature of scarring and fibrosis. While scarring is part of the wound healing response, fibrosis represents a failure to terminate tissue repair. In this context, tumors can be considered as “wounds that do not heal”. While studying spinal cord injury-induced scarring, a subpopulation of perivascular cells, type A pericytes, has been shown to be a major source of the stromal scar. Type A pericytes are embedded in the vascular wall but proliferate and leave blood vessels upon injury, differentiating into fibroblast-like cells that deposit extracellular matrix and form the stromal scar. Here, I propose to determine whether type A pericytes are a source of tumor stroma and whether blocking type A pericyte-derived stroma formation can impede cancer progression. Single cell studies to determine pericyte heterogeneity within malignant and non-malignant tissue will be performed. This characterization of heterogeneity is important to distinguish stroma-forming pericytes from the non-forming ones and from tumor cell-derived pericytes as described in Glioblastoma multiforme (GBM). Furthermore, by using combinations of pericyte reporter mice with genetic tools to manipulate pathways regulating cell proliferation and recruitment within specific pericyte subpopulations, I aim to investigate underlying mechanisms mediating pericyte-derived stroma generation. Studying stroma formation using the GBM mouse model, the proposed research intends to uncover common mechanisms of tumor stroma formation and identify new targets for therapy.
Method and apparatus for a joint start-up and stopping of the spinning positions of an open-end spinning machine

The start-stop program for the open-end spinning machine causes the external suction means to be rendered ineffective during the stopping process before the rotor falls below a speed necessary to maintain tension in the fiber ring in the fiber collecting groove of the rotor. Also, the program causes the external suction means to be effective on the rotor during a start-up only after the rotor has reached a speed sufficient to maintain the fiber ring tensioned in the collecting groove.
FEUILLE DE PLASTIQUE RENFORCEE PAR FIBRES ET PROCEDE D'APPLICATION DE FINI DE SURFACE POUR BETON.

<P>Feuille de plastique (11) renforcée par fibres à encastrer dans une couche de mortier (8) formée sur une surface d'un élément en béton (7), se présentant sous la forme d'un non-tissé réalisé en entrelaçant de courtes fibres de renforcement (2) de manière tridimensionnelle et en les fixant les unes aux autres à leurs points de contact avec une résine de cuisson, et la feuille comportant une pluralité de trous (6). La feuille de plastique renforcée par fibres est utilisée conjointement à des matériaux de construction et devient fermement intégrée au mortier (8) afin de réduire considérablement les tensions dues à des mouvements différentiels qui sont provoqués par un changement de température et un tremblement de terre, et d'empêcher le matériau (70) et l'élément de finissage de surface de se détacher et de tomber de la surface extérieure de l'élément en béton (7) du bâtiment.</P>
Pragmatics of intercultural communication

This article explains why intercultural communication always should be studied in context and how even though misunderstanding is normally at stake in intercultural communication, one can argue that the promotion of mutual understanding actually is of mutual interest for all of humanity. Studying in context means paying attention to circumstances around the uses of signs as well as to the roles and moods of the users of signs. Promoting mutual understanding means avoiding a state of mind that implies the depreciation of the other. To be intercultural, a communication must not be infected by prejudices. Any real attempt at intercultural communication is a paradoxical procedure. It supposes that human beings who engage in it at one and the same time recognize the stranger as similar and as different. Also, it can lead to acceptance of the other and a better understanding of what communication is about as well as to rejection and obscurantism. In this paper, I argue that even though people always relate in various ways to common and different cultural backgrounds, they still have to relate to common issues that govern their ways, and that focusing on those common issues and studying the various communicative contexts and contents help promoting mutual understanding, as these activities highlight the implicit role of the value of respect in all interpersonal communication. Human beings cannot avoid evaluating situations, contexts, relations, peoples and cultures. How can we establish that mutual respect and open-mindedness are better than disdain and dogmatism? Well, precisely by affirming that human relations commonly build on the inevitability of communicating and contrasting values and norms. Meaning in interaction permanently transforms cultural elements and patterns into something new. Intercultural communication becomes more respectable when it acknowledges the variety of ways humans interact meaningfully and the plurality of their logic of (inter-)action. It is good and reasonable to value understanding because this variety and this pluralism always have kept the social alive and more than ever in our modern globalized world contribute to the creativity and interactivity of modern life. The interest of pragmatics in user attitudes, its focus on practical rather than on alethic modalities, can contribute to a more nuanced approach to intercultural communication, where the different elements of meaning in interaction can be studied in various bundles rather than in a single strand.
TYRE AND METAL/RUBBER COMPOSITE THEREFOR

The invention relates to a tyre provided with a crown covered with a belt thread, a top reinforcement, two sidewalls and two beads, a carcass reinforcement passing in two sidewalls and anchored in each bead by anchoring means which comprises at least one bead, a circumferential alignment of at least one circumferentially oriented anchoring reinforcement interacting with a rubber called anchoring gum composition. Said tyre is characterised in that the anchoring reinforcement is embodied in the form of a two-layer M+N structured wire rope comprising an internal layer C1 consisting of M wires with a diameter d1 which are jointly helically wound with a pitch p1, wherein said layer C1 is also surrounded with an external layer C2 consisting of N wires with a diameter d2 which are jointly helically wound with a pitch p2 and said anchoring wire rope exhibits the following characteristics (d1, d2, p1 and p2 in mm): 2=M= 4, M+3=N=M+7, 0,25<D1< 0,40; 0,25<D2<0,40; 3,5<P1<7<P2<14. Said invention also relates to a metal/rubber composition comprising said two-layer wire rope associated with a high-rigid rubber matrix which has, in the vulcanised state thereof, a secant extension modulus for elongation of 10 % is greater that 20 MPa.
Parallel Computation for Stereovision Obstacle Detection of Autonomous Vehicles Using GPU

Due to the parallelism on general-purpose computation, the graphics processing unit (GPU) is applied in autonomous vehicles and a stereovision obstacle detection system is developed. We first perform census transform on the rectified stereo image pair; then employ the epipolar constraint to facilitate the visual correspondence matching. Based on the dense disparity map, the 3D coordinate of each pixel is calculated, according to which obstacles are identified. Furthermore, several techniques are listed for exploring the specific functionalities of GPU to boost the overall performance. A prototype system is finally implemented and integrated in the onboard PC of autonomous vehicles. Experimental results validate the real-time accuracy under various illuminations and road conditions. Since the low level image-processings are run by GPU in parallel, the proposed design not only merits high speed and efficiency, but also frees up CPU so as to focus on the decision and control.