SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Rac1 and Cdc42 are regulators of HRasV12-transformation and angiogenic factors in human fibroblasts

Abstract Background The activities of Rac1 and Cdc42 are essential for HRas-induced transformation of rodent fibroblasts. What is more, expression of constitutively activated mutants of Rac1 and/or Cdc42 is sufficient for their malignant transformation. The role for these two Rho GTPases in HRas-mediated transformation of human fibroblasts has not been studied. Here we evaluated the contribution of Rac1 and Cdc42 to maintaining HRas-induced transformation of human fibroblasts, and determined the ability of constitutively activated mutants of Rac1 or Cdc42 to induce malignant transformation of a human fibroblast cell strain. Methods Under the control of a tetracycline regulatable promoter, dominant negative mutants of Rac1 and Cdc42 were expressed in a human HRas-transformed, tumor derived fibroblast cell line. These cells were used to determine the roles of Rac1 and/or Cdc42 proteins in maintaining HRas-induced transformed phenotypes. Similarly, constitutively active mutants were expressed in a non-transformed human fibroblast cell strain to evaluate their potential to induce malignant transformation. Affymetrix GeneChip arrays were used for transcriptome analyses, and observed expression differences were subsequently validated using protein assays. Results Expression of dominant negative Rac1 and/or Cdc42 significantly altered transformed phenotypes of HRas malignantly transformed human fibroblasts. In contrast, expression of constitutively active mutants of Rac1 or Cdc42 was not sufficient to induce malignant transformation. Microarray analysis revealed that the expression of 29 genes was dependent on Rac1 and Cdc42, many of which are known to play a role in cancer. The dependence of two such genes, uPA and VEGF was further validated in both normoxic and hypoxic conditions. Conclusion(s) The results presented here indicate that expression of both Rac1 and Cdc42 is necessary for maintaining several transformed phenotypes in oncogenic HRas transformed human cells, including their ability to form tumors in athymic mice. Our data also indicate that expression of either activated Rac1 or Cdc42 alone is not sufficient for malignant transformation of human fibroblasts, although each is required for specific transformed phenotypes. Furthermore, our study elucidates that the expression of several highly significant cancer related genes require the activities of Rac1 and/or Cdc42 which may also play a critical role in cellular transformation.
Mutational analysis of kinetic partitioning in protein folding and protein–DNA binding

Kinetic partitioning between competing routes is present in many biological processes. Here, we propose a methodology to characterize kinetic partitioning through site-directed mutagenesis and apply it to parallel routes for unfolding of the TI I27 protein and for recognition of its target DNA by the human papillomavirus E2 protein. The balance between the two competing reaction routes can be quantified by the partitioning constant K(p). K(p) is easily modulated by point mutations, opening the way for the rational design of kinetic partitioning. Conserved wild-type residues strongly favor one of the two competing reactions, suggesting that in these systems there is an evolutionary pressure to shift partitioning towards a certain route. The mutations with the largest effects on partitioning cluster together in space, defining the protein regions most relevant for the modulation of partitioning. Such regions are neither fully coincident with nor strictly segregated from the regions that are important from each competing reaction. We dissected the mutational effects on partitioning into the contributions from each competing route using a new parameter called pi-value. The results suggest how the design of kinetic partitioning may be approached in each case.
CASTELNOVO RESORT BENESSERE NEI MONTI RESIDENZA TURISTICO ALBERGHIERA FINALIZZATA AL BENESSERE, ALLE ATTIVITA OUTDOOR E ALLA PROMOZIONE DEI PRODOTTI LOCALI.

CASTELNOVO RESORT BENESSERE NEI MONTI RESIDENZA TURISTICO ALBERGHIERA FINALIZZATA AL BENESSERE, ALLE ATTIVITA OUTDOOR E ALLA PROMOZIONE DEI PRODOTTI LOCALI.
Internet of things air tester as a new standards based wearable monitoring station for personalized indoor and outdoor air quality real-time assessment

We are a Portuguese SME, which provides Indoor Air Quality (IAQ) and Sick Building Syndrome (SBS) audits, and
Environmental analysis services. We have been working in the development of a disruptive way to improve the monitoring
of indoor and outdoor air quality using the Citizen Observatories model as the strategic approach for our business. To this
end we aim to prototype, test and commercialise an IoT wearable air quality monitoring system for both professional auditors
and citizens.
IAQ audits are a key tool to prevent health risks and spur productivity, while supporting energy efficient measures. Auditing
IAQ involves various unknown variables which impact on the cost, the time and the effectiveness of the audit.
We have a clear and disruptive business opportunity, as an IoT IAQ system that would enable easy and fast monitoring of
physico-chemical IAQ indicators in whole buildings using its own occupants as mobile monitoring stations, will increase the
efficiency and effectiveness of audits at a lower cost.
habITAT addresses priorities of the EC aligned within Europe 2020 Flagship Initiatives , the Environment Action
Programme , the Eco-innovation Action Plan and the EU Expert Group on Indoor Air Quality.
Objectives of the feasibility study: 1) Examine the technical feasibility of the solution to achieve a good problem-solution fit
that will enable jump-start product adoption, and bridge innovators with early adopters; 2) Examine the commercial feasibility
to achieve a good product-market fit that will enable bridging early adopters with early majority in the product life cycle.
Knowledge and practice of recreational tanning among female college students in the Eastern province of Saudi Arabia. A cross sectional study

Abstract Recreational tanning has become popular among young Saudi women. This study investigates whether Saudi female college students are practicing recreational tanning and analyzes the level of their awareness regarding the consequences of tanning as a cause for skin cancer and photoaging. A cross-sectional study of randomly selected female college students from two non-medical universities from the Eastern province of Saudi Arabia. The total number of participants was n  = 249. About 21.5% of participants with skin type I–II preferred outdoor tanning and no one preferred indoor tanning. Of those with skin type III–V, 23% preferred outdoor tanning, and 2.5% preferred indoor tanning. Among subjects who practiced both indoor and outdoor tanning 63% stayed more than 20 min while 36% stayed less than 20 min. The use of sunscreen was practiced in 70% of those who tanned. Sixty percent of subjects did not know that tanning caused early skin aging and 44% did not know the relationship of skin cancer and tanning. A significant number of Saudi female college students practice recreational tanning, regardless of their skin type. There is a clear lack of knowledge on tanning effect on risk of skin cancer and photoaging.
Energy Smart Mediterranean Schools Network

The energy trends in the Mediterranean region are characterized by the growing demand for energy, fossil fuels dependence, high CO2 emissions, etc., with negative consequences on the environment. Buildings are responsible for a significant part of the total energy consumption, causing 36% of CO2 emissions. In this context, increasing the energy performance of the building stock has a key role to play in the transition to a smarter, renewable-intensive and decarbonised energy system and, in the longer term, to a climate-neutral economy. ESMES project will specifically focus on the optimization of energy consumption in public schools through innovative, monitoring-based renewable energy and energy efficiency (REEE) pilot actions. At the same time, the project will improve the capacity of 5 public institutions in order to implement innovative energy rehabilitations.
Doak's momentum potential theory of energy flux used to study a solenoidal wavepacket

Abstract Doak's momentum potential theory of energy flux is explored using a model problem constructed to facilitate the introduction of solenoidal perturbations, in a controlled manner, to an otherwise well-understood sound generation problem: that of an irrotational, subsonically convecting wavepacket. The solenoidal wavepacket has, in addition to a downstream radiation lobe similar to its irrotational counterpart, lower level radiation in the sideline direction. Helmholtz decomposition of the linear momentum and subsequent exploration of the various source and flux terms that participate, according to Doak's fluctuation-energy balance, in the generation and transport of total fluctuating enthalpy (TFE) reveal a rich inner structure involving work performed on, and extracted from, the fluid system by means of the irrotational and solenoidal components of the wavepacket. The response of the fluid involves the internal transport and attentuation of trapped TFE, as well as the radiation of a small amount of radiating TFE. The analysis shows how the downstream radiation is associated with a mechanism similar to that of the irrotational wavepacket, while the sideline radiation arises due to the scattering of irrotational wavepacket fluctuations by solenoidal momentum fluctuations. It is postulated that such a mechanism might play a role in the sideline radiation of subsonic jets.
PRIVATIZACIJA INA-e; UZROCI, MODEL, POSLJEDICE

In Croatia, the 90’s of last century were implemented processes of transformation and privatization. Croatian privatization model was designed in such a way that it consisted of two stages; transformation and privatization. The process of transformation of social ownership began on April 23, 1991. Transformation stage is marked by two parallel flow; formal legal flows and financial flows transformation. The second stage of the privatization process of was privatization stage, which is divided into the privatization portfolio held by the Croatian Privatization Fund (HFP), within which we have the coupon privatization and the privatization that takes place outside of the HFP (privatization of public enterprises and privatization of the banking industry). The privatization process started in May 1, 1993. In the process of privatization of public enterprises moved on to the privatization of INA.
Since 1990, INA is a company owned by the state and since 1993 a joint stock company. The first stage of privatization, in which the purchase of 25 percent plus one share of INA's strategic partner MOL station, completed in 2003. In 2006 INA went into the next stage of privatization when the Government has launched the sale of 1,700,000 of its common shares. In January 2009 MOL and the Croatian government signed the Amendment to the Shareholders Agreement. Pursuant to these agreements, INA, d.d exits from the regulated part of the gas business. The fact that the established inquiry commission for the privatization of INA that former Prime Minister Ivo Sanader was arrested and tried for accepting bribes from MOL that the Republic of Croatia filed an arbitration claim against MOL, and information studies of US consulting firm AT & Karney and Oil & gas Consulting which showed that MOL following the takeover of INA Croatian side of non-compliance with the agreement damaged for $ 6.2 billion refer to the lack of strategy on Croatia's energy future, but on the contrary show that the privatization of INA is entered without a strategy and with only one goal and that is to meet their own and political interests. The desire of the author is that of errors that occurred in the privatization of INA, learn something privatization yet to come, that such mistakes would not happen again. INA is one of the companies which are the carriers of the Croatian economy, unfortunately we didn´t treated her on that way. The question is what is the Republic of Croatia could get to the INA remained in its majority property. They are now just speculation. Financial results of INA´s last year are positive. Indicators for 2015 and the first quarter of 2016 indicate that operates at a loss, and the time will show what happens next.
Environmental and Economic BEnefits from BIochar clusterS in the Central area

Emissions from fossil fuels are the largest contributor to the anthropogenic greenhouse effect, so a reduction in fossil-energy use is a clear priority for the environment. Yet, because some emissions will be unavoidable, a responsible strategy also means actively withdrawing carbon dioxide from the atmosphere. Such carbon sequestration faces multi-faceted challenges: the net withdrawal of carbon dioxide must be long-term and substantial; the process must be accountable; and it must have a low risk of rapid or large-scale leakage. One near-term technology that can meet these requirements is biochar sequestration. When combined with bioenergy production, it is a clean energy technology that reduces emissions as well as sequesters carbon.

The E2BEBIS project aims at developing regional energy clusters adopting the biochar technology, and at advancing the related policies through its full legal adoption by competent authorities at the national and the EU level. The transnational Central dimension helps considering the adoption of such technology in context featuring different environmental conditions, different types of biomass, different local administrations.
Mitigating Vulnerability of Water Resources under Climate Change 

Water resources are under increasing pressure originating from land use and climate change. Accompanied with economic changes in the SEE region the land use pattern is expected to change, too. Both processes will have severe impacts on water resources in general and drinking water resources in particular. CC-WARE aims at developing an integrated transnational strategy for water protection and mitigating water resources vulnerability which builds the basis for an implementation of national / regional action plans. The strategy for national action plans transfers the achieved and developed knowledge and resulting measures into the regions and on local level to strengthen the institutional capacity and human resources at national, regional and local level. A framework will be setup on national level in regard to legislation and national / regional institutional structures to be able to implement the strategy developed on transnational level smoothly after project duration to assure a long term impact of CC-WARE project. The promotion of implementing national activities for mitigating vulnerability of drinking water supply based on a jointly developed transnational strategy will be extended to the entire SEE area with special regard to preaccession countries. Through consultations, workshops and publications; gained knowledge will be transferred to relevant policy makers and stakeholders particularly of pre-accession countries the reach the upmost dissemination. Moreover, the present and future vulnerability will be assessed based on a jointly elaborated methodology. Necessary vulnerability indicators representing the SEE area will be defined to evaluate water vulnerability concerning as well quantity as quality and to assess and classify drinking water availability under changing climate and socio-economic conditions. This enables to generate a transnational SEE vulnerability map considering present and future regarding water quantity and water quality. Different water management options for water supply systems with special regard to ecosystem services (ES) of various ecosystems will be evaluated and land use regulations analysed to define their impact on drinking water resources and propose improvements of land use regulations to assure a safe drinking water supply. The main ES which will be assessed in the course of the project is the supply of pure drinking water in appropriate quantity in different climate regions and homogeneous areas (forestry, agriculture, wetland and urban areas) to get a framework which has relevance for drinking water source protection management. Furthermore a common catalogue of recommendations for economic incentives for water management will be jointly elaborated based on experiences from water suppliers and best practice examples. Lastly, communication and dissemination activities and measures are applied on various different levels such as on different policy levels including different target groups and stakeholders and covering different spatial areas and scales within the SEE area.
The integrated landscape of driver genomic alterations in glioblastoma

Glioblastoma is one of the most challenging forms of cancer to treat. Here we describe a computational platform that integrates the analysis of copy number variations and somatic mutations and unravels the landscape of in-frame gene fusions in glioblastoma. We found mutations with loss of heterozygosity in LZTR1, encoding an adaptor of CUL3-containing E3 ligase complexes. Mutations and deletions disrupt LZTR1 function, which restrains the self renewal and growth of glioma spheres that retain stem cell features. Loss-of-function mutations in CTNND2 target a neural-specific gene and are associated with the transformation of glioma cells along the very aggressive mesenchymal phenotype. We also report recurrent translocations that fuse the coding sequence of EGFR to several partners, with EGFR-SEPT14 being the most frequent functional gene fusion in human glioblastoma. EGFR-SEPT14 fusions activate STAT3 signaling and confer mitogen independence and sensitivity to EGFR inhibition. These results provide insights into the pathogenesis of glioblastoma and highlight new targets for therapeutic intervention.
The Karst district-Distretto del Carso

The project regards the Italian and Slovenian Karst area as a homogeneous territorial entity and aims at establishing joint targeted planning initiatives to enhance the natural Karst environment. In this sense, Karst is regarded as a contact area for the implementation of sustainable development programmes and policies aimed at improving the quality of the local population’s life, the environment and the cross-border territory, while taking into account the available human resources and the socio-economic and environmental features of the local territory. Specifically, the projects intends to set up a Joint Working Table bringing together the institutional actors involved, so as to strengthen existing networks of relations among those in charge of territorial planning and the use/optimization of public funding; economic operators are also called to participate, in order to outline a common vision that is organic, uniform and shared of the various problems and the potential for development of Karst. The project also entails the identification of strategies and administrative instruments contributing to a joint environmental planning in the field of water services, road networks, infrastructures, routes and trails, and telematic networks to benefit the local inhabitants and authorities, in order to improve their efficiency and effectiveness. Lastly, a feasibility study is carried out to evaluate the possibility to set up a joint body charged with the coordinated management and administration of the territory. The project will conclude with the drawing up of an “Agreement to establish the crossborder partnership for the development of Karst”, signed by fourteen Italian and Slovenian subjects (the Provinces of Trieste and Gorizia, 11 Municipalities and Agencies for the Local Development of Karst and Brkini), which represents the formal commitment to the implementation of cross-border cooperation projects in the framework of Programming Period 2007-2013.
A reputation risk perspective on the Greek crisis

The economic crisis of Europe has realigned the notion of a nation’s reputation (or its branding) in a prominent way. Using the case of Greece as an example, we interpret the Greek crisis from the fresh perspective of reputation risk management. From this perspective, we show that the Greek crisis, on one hand is deeper and more holistic than the pre-crisis dim macroeconomic outlook would suggest. From the other hand, we suggest that the crisis could have been avoided had reputation risk management been encapsulated as a mechanism for guiding Greece’s decision-makers. We infer that, the lack of the equivalent of national-level reputation risk management techniques at the governance echelons is one of the root causes of the crisis and the key catalyst for the rapid escalation of what at first instance appeared to be bad nationwide public financial practices and policy making into a European and nearly global financial event.
Parametric enhancement of flavor oscillation in a three-neutrino framework

When neutrinos travel through matter with a periodic density profile, the neutrino oscillation probability can be enhanced if certain conditions are satisfied. In a two-neutrino framework, the condition for parametric resonance is known. Herein, we consider the analogous parametric resonance condition within the context of a full three-neutrino framework with two oscillation scales. For energies in the range of hundreds of MeV to a few GeV, we find that neutrino oscillation can be parametrically enhanced if two approximate relations are satisfied. The first is similar to the two-neutrino parametric resonance condition while the second involves the other oscillation scale. Treating the Earth's density as piecewise constant, we show that oscillations in this energy range can be enhanced between two- and threefold.
New parties on the news: how new(s) media and new parties shape attention and electoral support for political ideas

For democracy, a necessary condition is openness to new political ideas. New ideas are often advanced by new political parties. New parties must rely on media to communicate with the electorate. In the process of that communication, it is inevitable that these media largely shape new parties’ public image.

However, studies of new parties pay little attention to media. Vice versa, studies of media pay little attention to new parties.

As a result, we lack a full explanation of new party emergence. This hinders our understanding of the openness of democratic systems, and of their current renewal. While Vox, M5S, and AfD experience unprecedented success, we hardly know
1. how (much) news media cover new parties;
2. what factors shape that coverage;
3. how (much) that coverage facilitates new party emergence;
4. how (much) social media use facilitates new party emergence.

NEWNEWS addresses these questions by developing and testing an Integrative Framework of  Political Party Gatekeeping. It adds to the literature in terms of theory (‘bringing in’ media and voter perceptions) and methodology (experimental methods and data science).

The project seizes new opportunities:
-Thanks to cutting edge analytical models, it adequately tests causes and electoral effects of that coverage, taking into account agency of new parties and heterogeneity of news outlets and voters;
-Thanks to recent data collection, it encompasses all national-level new parties in 19 countries since 1950 (instead of only successful ones);
-Thanks to innovations in automated content analysis, it maps national-level coverage of these parties in various offline and online sources (instead of only newspapers).

NEWNEWS will reveal media portrayals of new parties, how these portrayals vary, and how they matter for election outcomes. This way, it will offer a novel theoretical framework, conceptualisations, operationalisations, data, and algorithms – and open up new lines of research on media and new voices.