SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Networking, partnerships and tools to enhance in situ conservation of european plant genetic resources

The overarching objective of Farmer’s Pride is to establish a network of stakeholders and conservation sites that effectively coordinates conservation actions to safeguard the wealth of Europe’s in situ plant genetic resources (PGR) and integrates the user community to maximize their sustainable use. Specifically, to address the challenge and scope of the SFS-04-2017 work programme, Farmer’s Pride will: a) build relationships between existing diverse PGR stakeholder networks, and where necessary create new partnerships to establish a unified network of stakeholders involved in PGR conservation and sustainable use; b) enhance existing knowledge of European landrace and crop wild relative genetic diversity and showcase how it can be effectively secured and managed; c) use social science and economic tools to establish the value of in situ PGR populations and individual traits, as well as a cost effective means of conserving them; d) use predictive characterization methods to identify valuable traits in in situ PGR populations, targeting those most vital for satisfying future agricultural and market needs; e) establish a mechanism to facilitate the flow of plant genetic material from in situ populations to the user community, both directly and via ex situ collections; f) develop and establish a durable governance and resourcing structure for the European network of in situ PGR conservation sites and stakeholders; g) promote public awareness of the value of PGR for agriculture and consumers; and h) design and implement a network of European sites and stakeholders that conserves the breadth of PGR diversity found in situ. Through these activities, Farmer’s Pride will result in significant strengthening of European capacities for the conservation, management and sustainable use of in situ PGR as a foundation for increased competitiveness in the farming and breeding sectors, and ultimately for long-term food and nutritional security in Europe.
REALIZZAZIONE DI UNA STRUTTURA RICETTIVA EXTRA-ALBERGHIERA INQUADRABILE COME AFFITTACAMERE CON ANNESSA CAFFETTERIA

LA SOCIET PROPONENTE INTENDE REALIZZARE UNA STRUTTURA RICETTIVA NELLA CITT DI MATERA. L ATTIVIT CHE INTENDE SVOLGERE CONSISTE, INFATTI, NELLA GESTIONE DI UNA STRUTTURA RICETTIVA EXTRA-ALBERGHIERA (7 CAMERE), INQUADRABILE COME AFFITTACAMERE , MA CARATTERIZZATA DA UNO CHARME PARTICOLARE, TALE DA CATTURARE L ATTENZIONE DEI VIAGGIATORI ED ATTRARRE UNA CLIENTELA ALLA RICERCA DI ESPERIENZE UNICHE, IN PARTICOLAR MODO PROVENIENTE DALL ESTERO. LA STRUTTURA, UBICATA IN VIA LUCANA, IN PIENO CENTRO STORICO E IN PROSSIMIT DALLE PRINCIPALI VIE DI ACCESSO AI RIONI SASSI DI MATERA. OLTRE IL SERVIZIO DI OSPITALIT (CHE COSTITUISCE IL CORE BUSINESS DELL ATTIVIT ), L IMPRESA PREVEDE ALTRES , CON IL PRESENTE INVESTIMENTO, LA REALIZZAZIONE DI UN AMBIENTE CAFFETTERIA. CON IL PRESENTE INVESTIMENTO, LA SOCIET PROPONENTE INTENDE REALIZZARE LE OPERE MURARIE NECESSARIE ALL AVVIO DELLE ATTIVIT SOPRA DESCRITTE, NONCH DOTARSI DI TUTTI GLI ARREDI, LE ATTREZZATURE E I MACCHINARI NECESSARI AD UN EFFICIENTE S
Healthcare providers’ experiences with adverse drug reactions and adherence challenges in antiretroviral therapy of HIV patients in the Eastern Cape Province, South Africa

To gain insight into the experiences and handling of adverse drug reactions (ADRs) by the staffs of public primary healthcare (PHC) clinics in Eastern Cape Province, South Africa, as well as their perceptions of related adherence challenges in the treatment and follow-up of human immunodeficiency virus (HIV)-positive patients.Healthcare providers working at the PHC level in the public sector in the study area were approached and asked to participate in focus group discussions (FGDs). Seven FGDs were conducted with 32 healthcare providers (9 nurses, 23 auxiliary staff). Questions introduced by the moderator of each FGD were freely discussed by the participants. Discussions were audio-recorded and subjected to thematic content analysis.Several challenges in the treatment and follow-up of patients on ART were identified. These include: (1) lack of training of healthcare providers in PHC clinics to confidently identify, manage and treat the ADRs HIV-positive patients receiving ART; (2) patients' difficulty in communicating information on ADRS; (3) insufficient pharmacovigilance; (4) role of poverty.Both nurses and auxiliary staff expressed lack of knowledge and confidence regarding ADRs in HIV patients and management of this. More emphasis is warranted on training the healthcare providers to identify ADRs and provide adequate advice for continued treatment of patients experiencing potential drug related problems.
The transcription-related dna damage response

The cellular response to bulky DNA lesions, such as those induced by UV-irradiation, remains enigmatic despite decades of study. The effect of such damage on transcription is complex. At the local level, lesions cause stalling of RNAPII, resulting in a block to transcript elongation. Stalled RNAPII triggers transcription-coupled nucleotide excision repair, a process whereby lesions in genes are preferentially removed. Importantly, however, UV-irradiation also affects transcription genome-wide, so that even genes that are not damaged temporarily cease to be expressed. Alternative mRNA splicing also changes dramatically. The mechanisms and factors that underlie the global, damage-induced changes in gene expression, and its eventual normalization, are poorly understood. 
In order to facilitate identification of new factors and mechanisms involved in this response, we performed several distinct proteomic screens and an siRNA screen in parallel. This was complemented by characterization of transcription and mRNA splicing after DNA damage by genome-wide techniques. Any screening for new factors is high-risk, and the decision on which ‘hits’ to pursue is always difficult. Indeed, in any individual proteomic or genomic screen it is often impossible to distinguish ‘real’ hits from hundreds, if not thousands, of false-positives, and false-negative results are very frequent as well. Our multi-omic approach explores the same process from various angles and places less emphasis on hits from an individual screen and instead focuses on factors that score in several screens. This integration of screen results has resulted in the identification of several new factors and unexplored mechanisms. With a basis in exciting preliminary findings, this grant proposal thus describes a multi-disciplinary approach, including biochemical and cell biological approaches as well as proteomics and genomics, to characterize the transcription-related DNA damage response with an unprecedented scope.
Can “stranded” Fossil Fuel Reserves Drive CCS Deployment?

Abstract Recent studies have evaluated the climate change implications of burning all of the world's proven reserves of carbon. To stay below the ambitious target of two degrees Celsius of warming above average pre-industrial temperatures, the International Energy Agency (IEA) estimates that we would need to emit no more than 884 GtCO 2 globally between 2012 and 2050, equivalent to burning approximately one third of current global carbon reserves. This would require leaving large amounts of coal, oil and natural gas in the ground. These unutilized fossil reserves have been referred to as “stranded”. In this paper, we analyze CCS not as a cost, but as a potential enabler of utilizing otherwise stranded fossil fuels. We examine case studies at Boundary Dam and Gorgon, introduce a “CO 2 Normalized Price” as a useful metric for bottom-up assessments, and evaluate top-down model results to help value CCS as a way to rescue stranded fossil fuel assets.
Technological inequality – understanding the relation between recent technological innovations and social inequalities

Recent technological innovations may fundamentally change the size and nature of social inequalities. Success in labour markets and society will likely be driven by other skills than in the past, and traditional predictors of social mobility (e.g. class, credentials) are likely to be affected by these technological innovations. The empirical plausibility of potential implications is still ill-understood, and as a result it is unclear how governments can best respond to technological innovations. Most of the literature addresses the question of whether automation will create or destruct jobs. This project answers this question better, but also pushes beyond the research frontiers by focussing on the broader societal impact of technological developments. Our research will provide more precise forecasting of labour market consequences of technological innovations (WP1), explore new ways of measuring automation rates in European countries (WP1), explain how technological innovations are most likely to shape societal inequalities (WP2), study the role of various forms of education (WP3) and innovative forms of social welfare (WP4) in maximizing growth and reducing inequality, and assess the consequences of automation for public finances (WP5). We also assess whether and how the Fourth Industrial Revolution is different from earlier technological revolutions (WP6). TECHNEQUALITY will serve as a foundation for a better understanding of technologically driven social inequalities and a catalyst for new research. Innovative forecasting models on the impact of automation will enhance labour market macro-efficiency and equitable labour market outcomes. We will also set the agenda for policy debates on societal consequences of technological developments (WP7).  Our findings will spawn concrete and actionable policy impacts for national governments, the EU, and the OECD.
Integrated and Holistic Management of the Open Data Life Cycle

The project aims to strengthen the capacities of coordination and collaboration of the Italian and Swiss public administrations of the Insubric Region and to improve the processes of stakeholder participation by insisting on a critical area: the lack, the misalignment and under-utilization of common information and the burden data sharing. Once the information needs of the PA user and stakeholder system wil have been identified, the project will take care of selecting and analyzing the related data, making the structures homogeneous to promote integration, interoperability and exposure. The creation of a portal dedicated to the Insubric Region compliant to the Swiss portal for open government data is planned.
In vivo engineering of monocytes loaded with nano-chemotherapeutic formulations: a novel live-cell mediated drug delivery system for the treatment of cancer

The success of current antitumoural therapies largely depends on the availability of appropriate drug delivery strategies, which have to allow the penetration of these drugs through the tumoural microenvironment. The knowledge related to the cellular heterogeneity of the tumours has advanced enormously in the last years. Tumour associated macrophages (TAM) can represent up to 50% of the tumour mass. TAM are derived from circulating monocytes, which are recruited from the peripheral blood towards the tumour in response to a broad range of molecular signals (i.e. cytokines). Recently several studies are focused on the development of therapeutic strategies targeting TAM, however, the possibility to use monocytes, with excellent ability to infiltrate the abnormal tumoural tissue, to deliver chemotherapeutic drugs into the tumour has been hardly explored.

Here, we aim to use the host monocyte/macrophage cells, with high ability to infiltrate the tumoural tissues, to deliver nano-chemotherapeutic formulations into the bulk of the tumour. We will develop Nano-Formulations consisting in Hyaluronic Acid (HA) nanostructures decorated with beta-glucans, allowing the targeting of specific receptors on the host circulating monocytes (Dectin-1), and at the same time, the loading of chemotherapeutic drugs into these cells. Cytotoxic drugs inducing immunogenic cell death (i.e. bortezomib), and thus the recruitment of new monocytes, will be used to enhance the efficacy of the therapy. Overall, we will use Monocytes loaded with Nano-ChemoTherapeutic Formulations (MNCTFs) as a new strategy to deliver cytotoxic drugs towards the tumoural cells, taking advantage of the infiltration ability of the monocytes/macrophages into tumour microenvironment. The MNCTFs will be tested using appropriate in vitro 2D and 3D tumour models and in vivo murine tumour models. We expect that this new live-cell mediated drug delivery system will provide greater progress in the treatment of cancer.
A comparison of working memory characteristics in monkeys, apes, and humans.

Working memory is a central component of complex human cognitive abilities such as learning, language comprehension, planning, reasoning, and cognitive control (Engle, 1999; Unsworth & Robison, 2014). It allows for a limited amount of information to be kept available for processing in the absence of sustained sensory input, and the proficiency with which individuals do so is positively correlated with individual differences in scores of fluid intelligence (Baddeley & Hitch, 1974; McElree, 2006; Smith, Jonides, & Koeppe, 1996; Unsworth & Engle, 2007). Although working memory has been identified as central to human intelligent behavior (Cole & Braver, 2012; Engle, 1999), little is known about its evolutionary origins and our understanding of how it operates in nonhuman primates is only beginning to emerge (Carruthers, 2013). Thus, comparative studies of working memory are needed to determine what similarities and differences exist in working memory between humans and non-human primates. Indentifying such similarities and differences will elucidate what evolutionary factors such as the development of language, or increased frontal lobe capacity, may have been critical for the development of working memory in humans, and help us understand the origins human-like intelligence more broadly.
STORAGE DEVICE

A storing device with a storage space for storing objects that are especially liable to be stolen has a closing means (4), which is movable between an open position and a closed position closing the storage space, a locking means (5) which is settable between a locked position and an unlocked position for locking and releasing, respectively, the closing means (4) in a closed position, and a staining system (6) which is arranged in the storage space and adapted, in case of an attempted theft, to stain the objects stored in the storage space. The staining system (6) has a propellant source (7) which is arranged, when actuated, to expel a puff of propellant to a dye sprayer (8) which is connected to the propellant source (7) and contains a batch of dye to spray the batch of dye into the storage space when receiving this puff of propellant. The dye sprayer (8) is connected to the propellant source (7) via a valve body (12) which has an inlet (14) to which the propellant source (7) is connected, a first outlet (15) to which the dye sprayer (8) is connected, and a second outlet (16) which opens into the storage space. A valve element is movably arranged in the valve body (12) and connected to the locking means in such a manner that the propellant source via the valve body and the valve element is connected only to the first outlet (15) when the locking means (5) is in its locked position, and only to the second outlet (16) when the locking means (5) is in its unlocked position.
Promising results using sentinel node biopsy as a substitute for radical lymphadenectomy in endometrial cancer staging.

The objective of this study was to evaluate the efficacy of the sentinel node (SN) procedure in endometrial cancer patients.This was a prospective follow-up study including patients referred to Herlev Hospital, Denmark, to be treated for endometrial cancer in the period from October 2005 to December 2008. Hysteroscopy was performed with a 4.5 mm hysteroscope. Injections of 100-150 MBq (99m)Tc-traced colloid were administered subendometrially, and a dynamic scintigram was made. SN(s) identified with a gammaprobe were resected at the operation, and frozen sections were performed, followed by radical pelvic and para-aortic lymphadenectomy.A total of 32 patients were included. Among patients without clinical macro-metastases (n = 27), the SNs were detected by gamma probe in 23 (85.2%), and in most patients (n = 17, 74.0%) one (n = 12) or two (n = 5) SNs were found. The consistency between the scintigram and peroperative findings increased from 50.0% to 78.9% when the dose of (99m)Tc was increased to 150 MBq, mostly because the detection failure rate was lower at the higher dose: 4.8% versus 18.2%. By frozen section all macro-metastases were confirmed, but only one micro-metastasis was diagnosed. All subsequent lymph node metastases found in the final histology were found in SNs, i.e. no false negative SNs were found.The SN procedure can be used for endometrial cancer and it has a high detection rate and no false negative SNs were detected. The sensitivity of the SN procedure may be increased by the use of single-photon emission computed tomography (SPECT)/computed tomography (CT) and peroperative cytokeratin (CK) staining of the SN(s).External funding was received from the following University Foundation, Copenhagen County Research, Manufacturer Einar Willumsen's Memorial Foundation, Toyota Foundation Denmark, Lilly Benthine Lund Foundation.The study was registered with the Danish Data Protection Agency.
A Study of Surface Ozone Measurement atVadasery, Kanyakumari District

Ozone in the troposphere is a pollutant, a constituent of smog. Ground level ozone is regarded as a pollutant by the World Health Organisation. A high concentration of tropospheric ozone can contribute to a potentially important climate forcing, which needs to be properly assessed. In this study Surface ozone measurement was estimated at vadasery, which is one of the heavy traffic prone area in Kanyakumari district has been analysed for a period of 12 months .Ozone measurements was carried out by using a hand held ozone monitor from Aeroqual. In Diurnal variation cycle shows maximum value of ozone around 14.30 hrs and minimum around 5.30 hrs. The highest ozone concentrations was recorded in April ( 0.0583ppm) and minimum in June (0.010ppm) .Seasonal Variation of surface ozone showed maximum values during winter (0.05065ppm) and minimum values at Southwest monsoon(0.01411ppm).
Powerplatform: establishment of platform infrastructure for highly selective electrochemical conversions

The technologies to be developed in the PERFORM project are directed towards highly efficient and integrated electrochemical systems which substantially improve oxidative chemical transformations based on bio-based feedstocks. PERFORM provides solutions for the need for the electrification of the chemical industry and will establish a flexible PowerPlatform pilot plant to be used also after the end of the project, allowing for continuing innovations and impact. Moreover, multi-step chemical conversions can be shortcut and performed in a single electrochemical cell, such that this can be considered as a disruptive technology. Therefore, the implementation of electrochemical production methods for value-added compounds will be a game changer, leading to more efficient and sustainable production.
System and method for formatting data for transmission between an embedded computer and a host computer having different machine characteristics

A system and method for providing seamless communication with threads executing on an embedded computer. Using a DAT system, a programmer can test the communication interfaces of a thread via either a scripting program, any COM-compliant program, or a graphical test utility. The DAT system automatically formats a block of data that is transmitted between the embedded computer and a host computer and accounts for machine specific enumeration sizes, machine specific pointer sizes, machine specific structure alignment boundaries, machine specific integer sizes, and machine specific byte ordering.
FABRIZIO MARRELLA. Manuale di Diritto del commercio internazionale

Este artículo reseña: Fabrizio Marrella, Manuale di Diritto. Del commercio internazionale. SecondaEdizione, Cedam, Milano, 2020, 936 pp. ISBN 9788813373672
Distribuição das chuvas no município de Tangará da Serra, médio norte do Estado de Mato Grosso, Brasil

It is of great importance to know the rain distribution in the region of Tangara da Serra (latitude 14°37’55”S, longitude 57°28’05”W and altitude 488 m), as it is an agricultural region, which makes such information essential for an adequate planning, maximization of agricultural potential and optimization of hydric resources. Thus, this work was aimed at evaluating the annual, monthly and ten-day pluviometric variability, and also quantifying the number of dry and rainy days and different levels of rain probability for the region. Pluviometric data provided by ‘Agencia Nacional de Aguas’ (ANA) were used to analyze a period of 38 years (from January 1970 to December 2007). Precipitation behavior in Tangara da Serra has annual and monthly variations, constituting two well defined seasons – a dry one from May to September, and a rainy one from October to April. Annual variability during the analyzed period corresponds to the maximum value of 2,861, minimum of 1,404 and average of 1,830 mm, respectively. The incomplete gamma function adequately expresses precipitation probability in Tangara da Serra. Precipitation averages range from 40 to 50% probability for rainy months and from 30 to 40% for dry ones. According to the results, this type of research might help the elaboration and development of irrigation projects in this region.
The qur’an as a source for late antiquity

The Qur’an’s message to the populations of Mecca and Medina can only be fully understood in the context of its sustained and critical engagement with the Jewish and the Christian traditions. QaSLA complements and redevelops this approach from the ground up by utilizing the Qur’an across disciplines as witness to the history of Judaism and Christianity. Its innovation is twofold. The Qur’an, firstly, will become the primary literary source allowing us to sketch the religious landscape of the Arabian Peninsula, for which no comparable late antique witness exists. Secondly, the Qur’an’s testimony to the religious culture of its contemporaries will enable us to approach the development of Jewish and Christian traditions throughout Late Antiquity from a new perspective.

QaSLA’s main innovation consists in turning the table on the predominant hermeneutics of Western approaches to the Qur’an, which tend to focus on the question of how the Qur’an is influenced by Judaism and Christianity. By taxonomizing the religious profiles reflected in the demonstrable interface between the Qur’an and its Jewish and Christian contemporaries, the project first reorients and then revamps this approach. QaSLA initially analyses the affinity between the Qur’an and known forms of Judaism and Christianity surrounding Arabia in order to identify which biblical, exegetical, homiletic, legal, narrative, ritual, and poetic discourses and practices circulated within the peninsula. It then employs the Qur’an as a new vantage point from which to reconsider broader late antique religious trends across the Middle East. QaSLA combines expertise across disciplines to create a novel local Arabian and an enhanced longitudinal Middle Eastern understanding of Rabbinic Jewish and Syriac, Ethiopic and Arabic Christian cultures. In a final step, the project then returns to portray the Qur’an in sharper contradistinction to more clearly defined forms of Judaism and Christianity.