SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Solupore® - enabling the manufacture of affordable new treatments to cure cancer

There is encouraging news for cancer patients, a new treatment, cell immunotherapy, has been delivering spectacular
clinical results and is a game changer because it is an entirely new way of treating cancer. Cancer immunotherapy, in which
a patient’s own immune cells are ‘armed’ by cell engineering to target and kill cancer cells, gives levels of complete response
in patients. The first cell immunotherapy drug was approved in August 2017 at a price of $475,000 per treatment. To bring
these life-changing treatments to patients and relieve the European and global healthcare burden they must become
available at affordable costs. The one thing worse than failure is unaffordable success and the challenge with these
treatments is the complex and high-cost of manufacturing. Current cell engineering methods are very expensive to
manufacture. Avectas has developed Solupore, a cell engineering technology, which delivers cargo to cells and plays a
critical role in the manufacturing process. The technology works by temporarily making the cell membrane permeable and
allowing cargo into the cell. Crucially, cell health and functionality are preserved while there is a significant improvement on
the process time and costs. Avectas has demonstrated that the pilot system can successfully deliver clinically relevant cargo
to T cells. During this project, Avectas will scale and align Solupore to regulatory compliance enabling us to commercialise
it. The emerging and fast-growing cell immunotherapy market is set to be worth $20bn in 2020, with cell manufacturing
representing $5bn. Commercialisation of Solupore will take 1% of the €5bn market share by 2024 and will generate global
revenues for Avectas, building value for the company and creating highly skilled jobs which will result in a high-value,
knowledge-based EU company. There will be substantial European and global socio-economic impact on cancer patients
living longer, better quality lives.
SULFONAMIDE-CONTAINING INDOLE COMPOUNDS

Novel neovascularization inhibitors are constructed to provide antitumor agents which are superior in safety to conventional antitumor agents, are surely efficacious and can be administered over a prolonged period of time. Namely, indole compounds represented by general formula (I) or pharmacologically acceptable salts thereof or hydrates of the same wherein R<1> represents hydrogen, etc.; R<2> and R<3> are the same or different and each represents hydrogen, etc.; R<4> represents hydrogen or lower (C1-4) alkyl; and the ring A represents cyanophenyl, etc., provided that the following cases are excluded; the one where R<1>, R<2> and R<3> are all hydrogen atoms; the one where R<2> and R<3> are both hydrogen atoms; and the one where the ring A is an aminosulfonylphenyl group and R<1> and R<2> are both halogen atoms; and provided that when the ring A is a cyanophenyl, 2-amino-5-pyridyl or 2-halogeno-5-pyridyl group and R<1> is a cyano group or a halogen atom, then at least one of R<2> and R<3> is not hydrogen. <CHEM>
O.M.P.M. lifercraft tail innovative tool assembly

The aim of this proposal is to develop, design, manufacture and deliver to the Core Partner of the Call For Core Partner AIR-02-02, the prototype assembly and transportation tooling for all components of the LifeRCraft Rotorless Tail that belong to the WP_B4.1 “Rotorless Tail for LifeRCraft” i.e.: Tail Boom, Horizontal Stabilizer, Vertical stabilizer, Control Surfaces, Upper Tail Boom Fairing. Components will be assembled using composite and metal parts. According to objective of call in terms of cost, schedule and energy saving, the proposal outlines different assembly approach including traditional one based on hard assembly jig,  determined assembly using predrilled holes on separate parts and measurement based assembly system. Based on the proponent know how,  for each one,  advantages and disadvantages are described. Assembly approach will be selected in close agreement with core partner responsible of tail assembly. In the proposal WP1, after an Harmonization phase, the assembly jigs complete with auxiliary tools as drilling template, sling etc. and transportation tools will be designed and fabricated. After dimensional and functional check the assembly jig and transportation tools will be delivered to the Core Partner responsible for tail assembly and transportation. The following WP2 will be devoted to assessment of delivered tools to report configuration trades and support tool try out. Finally in the WP3 the proponent will support the Core Partner in tool try out and use of jig for component assembly and transportation. If major tooling modifications will derive from ground and flight test the additional work required to comply with necessary design and tool modification will be negotiated with core partner. WP 4 will handle all the management, communication and dissemination activities.
Eosinophilic Granulomatosis with Polyangiitis of the Major Salivary Glands: A Case of Sialadenitis in a Young Patient

A 23-year-old man was referred to our Emergency Department due to an acute-onset hemoptysis and the associated bilateral swelling of all of his major salivary glands. The elevated levels of systemic inflammatory markers with hypereosinophilia and the concurrent presence of multiple lung infiltrates made it difficult to perform a differential diagnosis, as these symptoms can also be indicative of infectious, autoimmune or hematologic disorders. A histological examination of the patient's left submandibular gland revealed strong clues as to the final diagnosis of eosinophilic granulomatosis with polyangiitis with an atypical clinical presentation, thus allowing for the administration of early and successful conservative therapy. The outcome of our case suggests that systemic vasculitis represents a rare but possible cause of acute bilateral sialadenitis in young patients.
Method and device to optimize route plans on line networks

Die Erfindung beschreibt ein Verfahren und eine Anordnung zur Fahrplanoptimierung in Liniennetzen sowie ein entsprechendes Computerprogramm-Erzeugnis und ein entsprechendes computerlesbares Speichermedium, welche insbesondere eingesetzt werden können zur Erstellung von Fahrplänen, die optimal bezüglich Energieverbrauch (unter Berücksichtigung des Rückspeiseeffktes) und/oder zeitlicher Verteilung des Energiebedarfs (Desynchronisation) ausgelegt sind. Erforderlichenfalls können weitere Optmierungsparameter berücksichtigt werden wie: Summe der Umsteigezeiten, Anzahl der benötigten Fahrzeuge und Verspätungssumme der betrachteten Fahrpläne. Zur Lösung des Optimierungsproblems wird der (kontinuierliche) Lösungsraum diskretisiert. Die Fahrplanoptimierung kann als enumeratives Verfahren oder - ausgehend von einer Startlösung - ein lokales Suchverfahren ausgeführt werden. Die Effizienz wird durch den Einsatz eines Sweep-Line-Algorithmus erreicht.
Biotrem - processing wheat bran into packaging products

Project’s aim is to successfully commercialize BIOTREM technology – globally-unique, innovative and patented, sustainable method of processing by-products of the milling industry.

Using modified servo-presses, the technology, allows moulding wheat-bran into designated forms. After processing the mouldings gain market value as biodegradable packaging. Their main application concerns disposable tableware or food-service take-away-containers.

Biotrem packaging products are simultaneously bio-based, biodegradable within 30 days, use annually renewable agricultural side-products and are free of chemical additives. The above characteristics position Biotrem product line as a premium offer with environmental standards beyond its market counterparts.

Degradable packaging, as market research show, is the fastest growing niche of the packaging industry – a business opportunity the project plans to exploit, as it provides products that meet a demand generated by both legislation (imposing decrease of packaging waste) and consumer trends (environmentally conscious attitude). 

Having concluded necessary R&D works and completing investments assembling the production line, the company currently strives to optimize the technology in operational conditions and to specify its short-medium and medium-long term business strategy.
Social design of public services

The nine partner cities of the ‘CHANGE! – social design of public services’ network have a common vision to transform their public services (with a special emphasis on social services) towards a more collaborative service delivery by boosting local social networks and harnessing the power of relationships among citizens (people-powered social services). If they are successful, a local shift towards a more collaborative public service model will result in better and more efficient public service delivery, enhancing also the social capital and social inclusion within the local society.
Detection of diabetic cardiomyopathy in Egyptian children and adolescents with longstanding Type 1 diabetes and evaluating the effect of α-tocopherol supplementation on cardiac functions after 1 year; a single center prospective study.

Introduction Diabetic cardiomyopathy (DCM) is a serious complication that frequently occurs in patients with type 1 diabetes (T1D) necessitating early diagnosis. The aim of the current study was to detect subclinical DCM in Egyptian children and adolescents with T1D and evaluate the effect of antioxidants on myocardial dysfunction. Material and methods The current prospective observational cohort study included 81 T1D patients (9-20 years old) with diabetes duration &gt; 4 years compared to 50 age and sex matched non-diabetic controls. Serum N-terminal prohormone of brain natriuretic peptide (NT-proBNP) was assessed in addition to conventional echocardiography, tissue Doppler imaging (TDI) and speckle tracking echocardiography (STE). Patients with myocardial dysfunction were supplemented with vitamin E (α-tocopherol) as an antioxidant for 1 year, then follow up echocardiography was done. Results NT-proBNP was elevated in 73 (90.1%) patients, 50.6% had left ventricular (LV) diastolic dysfunction, 14.8% had right ventricular (RV) diastolic dysfunction, 84% had LV systolic dysfunction and 91.4% had RV systolic dysfunction with statistically significant difference compared to controls. There was a significant negative correlation between LV global longitudinal strain (GLS) and NT-proBNP (p&lt;0.001, r=-0.796). ROC curve analysis showed that NT-proBNP at a cut-off point ≥ 195 ng/ml detected LV systolic dysfunction function with 89.7% sensitivity and 84.6% specificity. Follow up after one year of α-tocopherol supplementation revealed significant improvement in LV systolic and diastolic functions as well as RV systolic dysfunction. Conclusions NT-proBNP and non-conventional echocardiography were useful in early detection of subclinical cardiomyopathy in patients with T1D. Antioxidant treatment improved subclinical myocardial dysfunction in T1D patients.
Ungulate tooth wear analysis as a proxy for neanderthal habitats changes during mis 4 and 3

Several methods are used in Pleistocene paleoenvironmental reconstitution, such as, biochemical, eco-morphologicals, dental wear or pollen analyses. The rigorous comparison and inclusion of several paleoenvironmental proxies in a single study is still in its early stages. Yet, these methods are complementary and their inclusion could bring greater precisions to the knowledge of local and regional paleoenvironmental. Toothclues is a multi-disciplinary and innovative project which aims, for the first time, to compare and combine herbivore paleodiet, eco-morphometry and paleobotanical data, obtaining a clear picture of the environment where Neanderthal groups lived and precise interactions between them and their biotope in three temporal scales. This study will focus on the North-western part of the Mediterranean basin (France and Spain) during the MIS 4 and 3 in order to evaluate Neanderthal adaptations to the climatic instability. We selected three archaeological sites in which both faunal and botanical elements were available in situ and well preserved. This study requests several areas of expertise and tools to be conducted. First, the diet of the ungulates will be determined using dental wear analysis. Then, post-cranial bones of ungulates will be studied through morphological and metric analyses using Geometric Morphometrics. Next, pollen data from the same localities will be compiled with the help of specialists and combined with the faunal proxies through statistical analysis. The development of a new method to combine three proxies which refer to various geographical (local/regional) and time (decades/years/season) scales will bring new information about paleoenvironmental features for the North-western part of the Mediterranean basin during MIS 4 and 3 with a great precision. Ultimately, ToothClues aim to understand the interaction between environment, preys and humans in order to evaluate the adaptability and resilience of Neanderthal societies.
EMERGENCY HEAT REMOVAL IN A LIGHT WATER REACTOR USING A PASSIVE ENDOTHERMIC REACTION COOLING SYSTEM (PERCS)

System of endothermic emergency cooling for nuclear reactors using passive convection cooling and an endothermic reactant system.
P-185 - Comparison of positive and negative perfectionism among a group of iranian bipolar, depressed and control subjects

Previous studies showed that perfectionism has an important role in the aetiology and maintenance of a variety of mental disorders. It seems the role of perfectionism in relation to bipolar and major depressive disorders is not clear. In the present study we investigated the differences among major depression, bipolar disorder, and control subjects regarding negative and positive perfectionism. 40 normal subjects as well as 80 depressed and bipolar subjects from Quds hospital in Sanadaj were chosen. Each group consisted of 40 subjects. The control group was matched with the other two groups in regard to sex, age, marital status, employment, economic class and education level. The bipolar and depressed subjects were interviewed based on criteria of the DSM IV in order to confirm the diagnosis. The members of control group had to first fill in the General Health questionnaire (GHQ) and after confirming their health they should have filled in the Positive and Negative Perfectionism Scale (PANPS). In the groups of bipolar and depressed subjects GHQ and then PANPS were carried out. Results show that there are significant differences among bipolar, depressed, and normal subjects regarding negative and positive perfectionism scores. Also the average score of negative perfectionism is higher among the depressed subjects in comparison to the bipolar disordered subjects. According to the present study although both bipolar and depressed subjects showed more negative and less positive perfectionism than the control group, the depressed group showed more negative perfectionism than the other two groups.
The application of Hopfield neural network in enhancing x ray image of steel pipe welding

This paper analyses the characters of x-ray image of thick and thin steel pipe. In order to enhance the x-ray image automatically and avoid deciding the image's degraded type, a gray mapping matrix is constructed to replace traditional gray transformation curves and the maximum dimension of the gray mapping matrix is 256×256. So the calculation time has little relation with the size of the image. The criterion function of image quality is used to evaluate the quality of the transformed image. By this way, the problem of image enhancement is transformed to an optimization problem. The paper presents Hopfield neural network to calculate the gray mapping matrix. The energy function and the calculation method are also given. Some examples show that the presented method is effective.
Salons internationaux de Ray Service, a.s., en 2017

La participation de Ray Service, a.s. à des foires commerciales étrangères en Allemagne, en Grande-Bretagne et aux Émirats arabes unis en 2017 dans le but de promouvoir les produits de l’entreprise sur les marchés étrangers. Des salons consacrés aux technologies de défense et de sécurité visiteront l’entreprise à Abu Dhabi et à Londres. Dans le domaine de l’aviation, c’est une foire commerciale à Hambourg et une grande opportunité d’établir une coopération dans le domaine de la technologie et de l’innovation est le salon de Cologne axé sur le sport automobile.
TRANSPORT SYSTEM

A device for transporting passengers and goods has at least one stationary magnetic track (2) for carrying a vehicle (1) provided with a magnetic levitation device. The vehicle (1) can also be provided with a driving mechanism for street traffic. The vehicle (1) is designed as an individual vehicle with an interchangeable energy supply block (13) for street traffic. The energy supply block (13) may be removed in the area of coupling points of the magnetic track (2) and loaded in the area of uncoupling points of the magnetic track (2). After passing the coupling points and joining the magnetic track (2), the vehicle can be accelerated by magnetic fields acting along the magnetic track (2) in high speed areas. After leaving the magnetic track (2), the vehicle (1) may be driven by another driving system.
Partial homogeneity based high-resolution nuclear magnetic resonance spectra under inhomogeneous magnetic fields

In nuclear magnetic resonance (NMR) technique, it is of great necessity and importance to obtain high-resolution spectra, especially under inhomogeneous magnetic fields. In this study, a method based on partial homogeneity is proposed for retrieving high-resolution one-dimensional NMR spectra under inhomogeneous fields. Signals from series of small voxels, which characterize high resolution due to small sizes, are recorded simultaneously. Then, an inhomogeneity correction algorithm is developed based on pattern recognition to correct the influence brought by field inhomogeneity automatically, thus yielding high-resolution information. Experiments on chemical solutions and fish spawn were carried out to demonstrate the performance of the proposed method. The proposed method serves as a single radiofrequency pulse high-resolution NMR spectroscopy under inhomogeneous fields and may provide an alternative of obtaining high-resolution spectra of in vivo living systems or chemical-reaction systems, where performances of conventional techniques are usually degenerated by field inhomogeneity.
Surface Wind Speed-SST Relationship During the Passage of Typhoons Over the South China Sea

The present study investigates the relationship of sea surface temperature (SST) and surface wind speed changes in the South China Sea (SCS) region during the passage of typhoons for May-October of 2000-2010. Analysis shows that the SST drop in a 2° × 2° box during the passage of typhoons is about 1-3°C in two days around the time of maximum surface wind speed for most of the SCS typhoon cases. The typhoon-induced SST cooling displays a tendency of increase with surface wind speed. There is no clear statistical relationship between the SST cooling and the surface wind weakening during the analysis period. The relative location of the cold SST patch and the low surface wind region varies from case to case and from time to time. The present result does not support the previously proposed SST cooling impact on the surface wind speed based on case studies.
Go with the flow

Membranes
Enhanced water transport occurs in a number of narrow pore channels, such as biological aquaporins. Tunuguntla et al. thoroughly characterized molecular transport through narrow carbon nanotubes (CNTs) (see the Perspective by Siwy and Fornasiero). In contrast to previous studies, the authors focused on water and ion transport through relatively short (∼10-nm) fragments of CNTs embedded in lipid bilayer membranes. Strong confinement generated highly accelerated water flow compared with that observed in biological water transporters. A key factor in the transport rate was the tunable rearrangement of intermolecular hydrogen bonding. Furthermore, by changing the charges at the mouth of the nanotube, the authors were able to alter the ion selectivity.

Science , this issue p. [792][1]; see also p. [753][2]

 [1]: /lookup/doi/10.1126/science.aan2438
 [2]: /lookup/doi/10.1126/science.aao2440
Rochas carbonatadas

Calcários e mármores são rochas carbonatadas amplamente utilizadas no património construído Português e que se caracterizam por possuírem composição química e mineralógica similares apesar de apresentarem texturas e propriedades diversas. O presente artigo aborda este recurso mineral do ponto de vista da sua utilização como material de construção em bens de elevado valor cultural e foca dois casos com relevância histórica no panorama nacional: o mármore de Trigaches que aflora perto de Beja, no Baixo-Alentejo e a Pedra de Ançã outrora explorada em Cantanhede, Coimbra.
Natural regeneration as an indicator of ecological restoration by applied nucleation and passive restoration

Abstract Passive restoration and applied nucleation are important strategies for large-scale gains and cost reduction in ecological restoration projects. Passive restoration uses the natural regeneration potential while applied nucleation recreates microhabitats, which facilitates ecological succession. In this study, we assessed floristic composition, structure and functional groups as ecological indicators to compare passive restoration (fenced site 12 year ago), applied nucleation (7 years of dense seedling planting) and riparian forest. The study was carried out in a Seasonal Semi-deciduous Forest region in the Pampa biome, in the South of Brazil. We measured and identified all shrub and tree individuals greater than 30 cm in height. Analysis of variance (ANOVA) followed by the Tukey test (p
Effects of NBR Particle Size on Performance of Carbon Fiber–Reinforced Paper-Based Friction Material

In the present work, three different sized nitrile–butadiene rubber (NBR) particles were used to modify carbon fiber–reinforced paper-based friction material (CFRPF). The effects of NBR particle size on performance of CFRPF were studied. The microstructure and properties of the samples were investigated by scanning electron microscopy, thermal analysis, and wet friction performance testing. Experimental results indicated that there were four stages in the thermal degradation of NBR-modified CFRPF. NBR particle size had a great effect on the first degradation stage (100–300°C). The highest friction coefficient was obtained with the sample containing the finest NBR particles. The wear rate of the friction materials decreased with an increase in NBR particle size. However, NBR particle size had little influence on the wear rate of the couple plate. The sample containing coarse NBR particles showed excellent friction stability under oil-lubricated conditions.
Adriatic Ionian Small Port Network

AI SMART Project aims to develop a common port network in the Adriatic-Ionian area based on the concept of "intelligent, green and integrated ports" enabling setting new green routes that can connect regional small ports in the cross-border countries involved. The project promotes the potentiality of the short sea routes, as integral and complementary part of intermodal TEN-T corridors, for a sustainable and inclusive transport services, in accordance with the objectives of the European 2030 Strategy for intelligent growth based on valorization of the natural and landscape resources of both coasts and hinterland. The project will increase the competitiveness of the regions involved, working on four directions:
- raise the quality of port services provided to users;
- create supplementary and advance tourist services that focus on high quality;
- set up common port networks for "green, inclusive and sustainable" short-sea corridors;
- enhance awareness of the protection of the local port network in support of the maritime sector.