SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Nanobodies and antibodies against 2019-ncov

Overview:
As of Feb 12th, 2020, the death toll of the 2019-nCoV (COVID-19) epidemic has surpassed 1000, rapidly eclipsing the total mortality of SARS. It has a current death rate estimate of around 2 deaths per 100 confirmed infections, is experiencing phenomenal growth in mainland China, and has the potential to spread globally over the coming months. While a vaccine may be useful for future epidemics of a similar virus, it is not clear that such a vaccine can be produced at a speed and scale sufficient to impact the current epidemic.

Objective:
Antibodies form the basis of a robust adaptive immune response to viral disease. Nearly all licensed vaccines mediate protection through the activity of antibodies and where vaccines are not available, passive infusion of monoclonal antibodies can fill the gap and control the infection. The overarching goal of the CoroNAb consortium is to rapidly identify, validate, and disseminate pre-clinical protein therapeutic candidates with neutralizing activity against 2019-nCoV, and to recommend where their use would be maximally effective.

Expected results:
Over the course of the project, we expect to design and synthesize recombinant variants of nCoV glycoproteins for immunization in mice, alpacas and macaques in order to generate and characterize multiple nCoV-neutralizing antibodies and nanobodies. We will develop efficient assays for the testing of such antibodies and exploit novel computational workflows to improve neutralizing antibody potency. Finally, we will employ mathematical modeling of the 2019-nCoV epidemic for forecasting intervention effectiveness.

Timeline:
We expect the project to deliver a number of nCoV neutralizing anti- and nanobodies of increasing potency over a 2 year period from start date.
Systems Pharmacology in Cancer

This chapter focuses on systems approach that can be successfully applied to the processes aimed at developing better anticancer therapeutic agents. Given the complexity of the human disease and the robust phenotypes of biological systems, it seems unlikely that modulating a single protein will be able to effectively reverse the disease process for every patient. This is particularly true in cancer, as the malignant process involves several aberrant compensatory signaling routes that bypass the inhibition of individual proteins. However, the major advance has been acquisition of the ability for precise measurement of the fundamental units of a complex system in a multiplex fashion, and thereby the ability to measure and to quantify the complexity. Accurate models of such systems provide the potential for predicting cellular outcomes. Systems strategies in cancer pharmacology can therefore be used to direct experimental focus, identify new targets for specific disease states, uncover mechanisms of action of a compound, identify likely combination therapies, and generate biomarkers of response. With the knowledge of the genome sequences, genetic tools to interrupt the function of specific genes and the availability of large libraries of small molecules targeting specific protein products, such systems approaches are now productive. Although the future is bright, applications of systems approaches in cancer pharmacology remain nascent and incomplete. There are special characteristics of cancer that both challenge and accelerate discovery in this field. The greatest challenge is the genetic plasticity and resulting complexity of the cancer genome; because of the unique mutations, rearrangements, and epigenetic changes, every cancer is a special genome in itself.
Absorptive capacity and benefits from FDI: Evidence from Chinese manufactured exports

China's global export rank rose from the 32nd in 1978 to the 1st in 2009, and in the same period China had been a top recipient of foreign direct investment (FDI) in the world. Does large FDI inflow automatically lead to the export boom? Or is it a must for China to have certain absorptive capacity (AC) given FDI? This work investigates how manufacturing exports (MX) are affected by the AC-FDI interaction. MX performance is assessed by three indicators: export capacity, export intensity, and export quality. AC is defined as a host-country's ability to capture potential benefits from FDI, and such ability is proxied by government FDI policy, human capital, RD (b) China's strong AC largely comes from well-designed FDI policy and high quality infrastructure, both of which complement with FDI in strengthening export capacity, intensity and quality; and (c) human capital and R&D seems to be more helpful for China to capture spillovers from FDI to export quality.
Conformational dynamics of supramolecular protein assemblies

Supramolecular protein assemblies including molecular motors, cytoskeletal filaments, chaperones, and ribosomes play a central role in a broad array of cellular functions ranging from cell division and motility to RNA and protein synthesis and folding. Single-particle reconstructions of such assemblies have been growing rapidly in recent years, providing increasingly high resolution structural information under native conditions. While the static structure of these assemblies provides essential insight into their mechanism of biological function, their dynamical motions provide additional important information that cannot be inferred from structure alone. Here we present an unsupervised computational framework for the analysis of high molecular weight protein assemblies and use it to analyze the conformational dynamics of structures deposited in the Electron Microscopy Data Bank. Protein assemblies are modeled using a recently introduced coarse-grained modeling framework based on the finite element method, which is used to compute equilibrium thermal fluctuations, elastic strain energy distributions associated with specific conformational transitions, and dynamical correlations in distant molecular domains. Results are presented in detail for the ribosome-bound termination factor RF2 from Escherichia coli, the nuclear pore complex from Dictyostelium discoideum, and the chaperonin GroEL from E. coli. Elastic strain energy distributions reveal hinge-regions associated with specific conformational change pathways, and correlations in collective molecular motions reveal dynamical coupling between distant molecular domains that suggest new, as well as confirm existing, allosteric mechanisms. Results are publically available for use in further investigation and interpretation of biological function including cooperative transitions, allosteric communication, and molecular mechanics, as well as in further classification and refinement of electron microscopy based structures.
ORGANOPHOSPHOROUS HYDROXAMIC ACID DERIVATIVES USED AS HERBICIDES

The invention relates to organophosphorous compounds of the general formula (I), in which A is selected from the group consisting of -CR5R6-, -CR5R6CH(OH)-, -CR5R6CO- and -COCR5R6-. The invention also relates to the use of said compounds as herbicides and to a method for the selective pre- and post-emergent control of weeds in useful plant cultures.
Small farms, small food businesses and sustainable food security

SALSA will assess the role of small farms and small food businesses in delivering a sustainable and secure supply of affordable, nutritious and culturally adequate food. SALSA will identify the mechanisms which, at different scales, can strengthen the role of small farms in food systems and thereby support sustainable food and nutrition security (FNS). By considering a gradient of 30 reference regions in Europe and in Africa, we will obtain a differentiated understanding of the role of small farms and small food businesses in very differently structured food systems and situations. 
SALSA will elaborate and implement a transdisciplinary, multi-scale approach that builds on and connects relevant theoretical and analytical frameworks within a food systems approach, and that uses qualitative, consultative and quantitative methods. We will also test a new combination of data-based methods and tools (including satellite technologies) for rigorously assessing in quantitative terms the interrelationships between small farms, other small food businesses and FNS, paying particular attention to limiting and enabling factors. SALSA will use participatory methods, at regional level, and establish a more global Community of Practice and multi-stakeholder learning platform, based on FAO’s TECA online communication and learning platform.
The SALSA consortium, and the joint learning and close cooperation, have both been designed with the EU - Africa dialogue in mind. Responding to the call we will unravel the complex interrelationships between small farms, small food businesses and FNS, and unfold the role played by small farms in (a) the balance between the different dimensions of sustainability, (b) maintaining more diverse production systems, (c) supporting the urban/rural balance in terms of labour and (d) in facilitating territorial development in countries facing a strong rural population growth.
[POSTER] Double Reality: Shifting the Gaze Between the Physical Object and Its Digital Representation

We present an eye-tracking study centered on the shift of focus from digital to physical layer in case of a handheld magic-lens system. In particular, we investigate which variables might affect the occurrence of such events. The experiment involved 35 participants who used a tablet AR application to explore structural behaviour through problem solving exercises. The tablet augmented the physical model of a structure with the information about the applied loads and the internal forces. Participants were asked to identify the nature of some forces by visual inspection. During the task they could freely navigate around the structure and touch it. Our results suggest that the amount of shifts to real-world objects is related to the user's spatial orientation rather than on the user's spatial skills or the digital augmentation flaws. Specifically, the probability of looking at the physical layer increases when rapid movements are performed. The task difficulty and the perceived controllability, although not influencing the number of shifts, affected the mental effort during such moments.
QUICK-FIT COUPLING FOR A WEARING PART OF A SOIL-WORKING TOOL

A wearing part arrangement (1) provided with a holder (11) providing releasable attachment of a wearing part (12) by means of a socket-and-pin type quick-fit coupling, wherein the holder (11) comprises a pair of opposing first guide portions (1132) being arranged to face corresponding supporting faces (1221) provided on the wearing part (12), and a pair of second guide portions (1134) arranged to face corresponding top faces (1223) of the wearing part (12), wherein one of the pair of the opposing first guide portions (1132) and the corresponding side supporting faces (1221) of the wearing part (12) is provided with at least one elevation (1222), and the other one of the pair of the opposing first guide portions (1132) and the corresponding side supporting faces (1221) is provided with a corresponding recess (1135) arranged for receipt of the elevation (1222) when the wearing part (12) is in engagement with the holder (11).
INSULATED FAÇADE SYSTEM

The invention concerns a building façade having an inner wall, an insulation layer, an outer cladding layer and profiles for securing the outer cladding to the inner wall. Air gab for ventilation is provided between the insulation layer and the outer cladding. The insulation layer comprises insulation panels having two major large surfaces and four minor edge surfaces and the insu¬ lation panels have layers of insulation of different densities extending paral¬ lel to the two major surfaces, where a layer with a density above an average density of the panel is facing the outer cladding.
GPCR Dimers Fall Apart

G protein-coupled receptors (GPCRs), also known as seven-transmembrane receptors (7TMRs), transduce various sensory and nonsensory signals. It is now widely accepted that these receptors associate with each other as homomeric or heteromeric dimers or as higher-order oligomers. This realization raises a number of questions regarding the quaternary structure of GPCRs and the function of GPCR oligomers: How does ligand binding in one protomer affect an associated protomer? What is the functional unit that activates downstream signaling molecules? What parts of the receptor form the interfaces between protomers? Where along the pathway from synthesis to degradation do oligomers form? Do they ever dissociate? Until recently, this last question has attracted little attention, and GPCR dimers and oligomers have generally been considered to be stable structures. However, biophysical studies have now begun to address this question, and the answer that is emerging will require a reassessment of the stable dimer model.
Multislice Computed Tomography of the First Rib: A Useful Technique for Bone Age Assessment

Macroscopic study of the first rib has been described by Kunos et al. as an efficient method of age estimation. We retrospectively reviewed a test sample of 160 first right ribs obtained from multislice computed tomography (MSCT) clinical investigations of living individuals aged 15-30 years old. Based on the descriptions of Kunos et al., we analyzed the morphological appearance of the sternal end of the first rib on two- and three-dimensional MSCT reconstructions and defined changes in appearance in stages (from 2 to 5). We also studied the calcification and ossification of the costal cartilage as an independent feature. By statistical analysis (ANOVA), we determined for each gender the correlation between the estimated stage of the costal face, the appearance of the costal cartilage, and the documented age of the subjects. We demonstrated that MSCT of the first rib appears to be an efficient noninvasive modality for bone age estimation.
Pediatric epileptogenic gangliogliomas: seizure outcome and surgical results

Object Ganglioglioma is the most common neoplasm causing focal epilepsy, accounting for approximately 40% of all epileptogenic tumors and for 1–4% of all pediatric CNS tumors. The optimal surgical treatment for pediatric epileptogenic ganglioglioma has not been fully established. The authors present their experience in the surgical management of these lesions. Methods The authors retrospectively analyzed seizure outcome and surgical results of pediatric patients with ganglioglioma treated with resection. The patients' charts were reviewed for demographic data, clinical presentation, surgical therapy, and follow-up. Results The 30 patients (17 boys, 13 girls) had a history of medically intractable epilepsy. Total resection of tumor was achieved with or without adjacent epileptogenic tissue resection in all patients except 1, who underwent cyst fenestration and biopsy. Intraoperative electrocorticography (ECoG) was used in 21 patients. If an active spike focus or profound attenuation was observed in adjacent tissues, resection of those tissues was performed in addition to complete tumor resection (lesionectomy). The interval between onset of seizures and surgery ranged from 1 month to 9 years (mean 1.6 years). Patient age at the time of surgery ranged from 9 months to 16.3 years (mean 8.6 years). Twenty-five patients (83.3%) had complex partial seizures and 5 (16.7%) had simple partial seizures. Eighteen tumors (60%) were temporal (14 temporomesial, 4 temporolateral), and 12 (40%) were extratemporal. The mean follow-up period was 3.4 years (range 1 month–8.16 years). In 2 cases (6.7%), tumor recurrence was observed. Outcome was Engel Class I in 27 cases (90.0%; 14 temporomesial, 4 temporolateral, 9 extratemporal) and Engel Class II in 3 (10.0%; all extratemporal). Tumor resection allowed good seizure control, especially in the 18 cases of temporal ganglioglioma (all Engel Class I postoperatively). Eleven patients underwent removal of extratumoral epileptogenic tissue (anterior temporal neocortex resection in 10, anterior temporal neocortex resection with anterior hippocampectomy in 1) in addition to lesionectomy using intraoperative ECoG. Conclusions Lesionectomy with adjacent temporal neocortex resection using intraoperative ECoG provided good seizure control of pediatric temporal ganglioglioma. For extratemporal ganglioglioma, lesionectomy alone can provide fairly good seizure control. Considering the memory function of the hippocampus, lesionectomy with adjacent temporal neocortical resection can be a safe, feasible, and effective treatment option for epileptogenic gangliogliomas in pediatric patients.
Living Wall Systems: A Technical Standard Proposal

Abstract Greenery is recognized as strategic element for the design and the regeneration of sustainable cities and buildings. Building integrated vegetation (BIV) offers many ecological benefits and an increasing number of local authorities, urban planners and architects are aware of these. Living Wall Systems (LWSs) can be classified as a BIV. LWSs can be assumed as self-sufficient vertical gardens that are attached to the exterior or interior of a building. Their environmental properties are remarkable, for these cities encouraging architects to use them. Nevertheless technical standards dealing with design, construction and maintenance of LWSs are rarely available. The objective of the research is to stimulate the LWSs development providing a technical standard proposal with information, and specifications. It tackles some aspects that should be considered significant in a standard such as: design guidelines; maintenance procedures; requirements and indicators for assessing the expected performances. The outcome of the paper can be used a first framework to make available harmonized information to stakeholders engaged in design, off-site and on-site production, as well as in operation and repair. The standard proposal encourages innovative and responsible LWS development, with a focus on ecological requirements. The proposal standard was implemented in consistency to an Italian standard (UNI 11235:2015). The UNI 11235 contains the instructions for designing, building up, monitoring and maintaining the green roofs. Although UNI 11235 is not an international standard it is based on a robust framework that can be applied at global scale and most importantly to LWS.
Measuring device

The measuring device has a housing 12 and a central measuring opening 14 that passes through the housing in a straight line and receives a work piece to be measured. The device has a measuring coil 16 disposed inside the housing which encloses the measuring opening and a coil carrier 18 positioned radially outside of the measuring coil which carries or holds the coil. The coil may detect induced eddy currents. The coil carrier is preferably fixed or clamped in place with the coil lying radially inside it. The coil carrier may comprise supports 20 that face radially inward to grip the coil. The device may comprise a heat shield 26 positioned radially within the measuring coil and which closes off the inside of the housing. The device may further comprise a cooling system 22 comprising a fluid such as water or air which is guided via a channel around the coil and/or heat shield. The device is able to function in rough and extreme environments, for example under great heat or in environments in which water or steam is found, such as in a rolling mill.
The design of a bus controller based on SOC in industrial control system

Based on the analysis of PC104 bus protocol, a design of synchronous PC104 bus controller is proposed in a SOC(System-on-Chip). With the demands of quick interrupt response time, low power and high reliability for the application of aviation and the characteristic of SOC, lots of efforts are made on the these targets. These techniques mainly include internal module data path optimization, internal module bus cycle speed-up. Some key signals are processed by noise-reduced scheme. Over-delay logic is added for recovery from possible halt state. Experiments show that the operating system booting time has been reduced by 7.3%, and the energy consumed is reduced by 17.1% corresponding. A SOC integrating this controller has been manufactured and the real system is quite reliable and the interrupt response time is reduced by 14%.
BRAGG GRATING PRESSURE SENSOR

The invention relates to a Bragg grating pressure sensor which is intended primarily for use in the chemical industry. The inventive sensor comprises, for example, an optical fibre (10) and a Bragg grating (14) which is formed in a segment (14) of the aforementioned fibre, said segment being subjected to pressure P. The invention also comprises lateral means (20) for supporting the aforementioned segment. Moreover, said segment of the fibre is prestressed in compression, the value of which is low compared to the measuring range of the sensor.
Miglioramento della capacità produttiva di Galvani Ltd.

Galvani Ltd. svolge la sua attività principale nel settore della lavorazione meccanica e chimica dei metalli. Negli ultimi anni, l'azienda è specializzata nel trattamento superficiale dei metalli, rispettivamente galvanica e rivestimenti polimerici. L'azienda possiede un impianto di zincatura e un impianto di trattamento delle acque reflue ad essa, un'officina di verniciatura a polveri, un'unità di trattamento meccanico dei metalli — taglio e piegatura di lamiere e aste, tornitura, fresatura, saldatura LAG/MAG. Nonostante le attrezzature disponibili, l'elevata competitività del mercato e la crescente domanda di tali servizi crea la necessità di espandere la capacità produttiva dell'azienda. Per ottimizzare i processi produttivi con il miglioramento della tecnologia, sono previste nuove macchine innovative, che porteranno ad un aumento della produttività, alla riduzione dei costi di produzione e al miglioramento della qualità dei servizi offerti dall'azienda. Questo sarà un prerequisito per entrare nel mercato internazionale e offrire prodotti di qualità ai clienti stranieri. L'accresciuta competitività contribuirà a una migliore realizzazione dei servizi offerti, sia sul mercato interno che sul mercato esterno. Con la realizzazione del progetto migliorerà la capacità produttiva di Galvani Ltd., aumenterà la competitività, che manterrà gli attuali clienti, ne attrarrà nuovi e creerà potenziali sui mercati sia locali che esteri.
Diastereoselective one-pot Wittig olefination–Michael addition and olefin cross metathesis strategy for total synthesis of cytotoxic natural product (+)-varitriol and its higher analogues

A stereoselective route for the total synthesis of anticancer marine natural product (+)-varitriol (1) is detailed herein. The impressive biological activity and interesting structural features of natural (+)-varitriol fuelled us to undertake the synthesis of some higher analogues (1a-j) of this molecule. The key features of the synthetic strategy include one-pot Wittig olefination followed by a highly diastereoselective oxa-Michael addition to assemble stereochemically pure tetrasubstituted THF moiety of the natural varitriol and olefin cross metathesis to couple the aromatic part with tetrasubstituted THF moiety. The total synthesis of title natural product is efficient with 21.8% overall yield for 9 linear steps from D-ribose and thus facilitates the more scaled-up practical route for the synthesis of 1 and its analogues as well. The synthetic (+)-varitriol (1) and its analogues were screened for their cytotoxicity. The present synthetic approach paves the way for preparation of numerous analogues of the title natural product for drug development.