SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Mechanisms of myelination – elucidating the diversity of oligodendroglial precursors and their local axon-glia interactions

Nervous system function requires precise communication between myriads of neurons and glia to generate and maintain a functional organ. Most axons are eventually surrounded with myelin, an insulating structure produced by specialized oligodendroglia. This cellular interaction enables fast signal transmission, ensures long-term axon survival, and is involved in regulating learning and memory formation.
The formation of new myelin during lifelong development and after myelin damage requires differentiation of oligodendroglial precursors. Although these cells are an abundant population, myelin repair is often inefficient and eventually fails. It is known that oligodendroglial precursors have diverse properties, but whether this diversity is at any level a regulatory factor for normal myelination, or causal to failure of myelin repair is unclear.
Here, I will elucidate the diversity of oligodendroglial precursors by carrying out the first global analysis of their population dynamics in the whole animal from specification to myelination. I will investigate how differentiation properties change over time, reveal whether this is due to intrinsic or extrinsic factors, and identify the underlying molecular mechanisms.
To achieve these goals I will use zebrafish, an ideally suited model organism for in vivo live cell imaging and genetic manipulation. I will carry out a clonal analysis of oligodendroglial precursor population dynamics during myelinated tract formation and after myelin damage. I will analyse the molecular signature of cells with different properties to identify crucial mediators. Lastly, I will investigate whether individual cells can show diversity at the subcellular mechanistic level of local axon-glial interactions.
My work will provide fundamentally new insights into the principles of the heterogeneity of oligodendroglial precursors and may help to device new strategies of how to employ these cells to form new myelin in development and disease.
Sending peacekeepers abroad, sharing power at home: Burundi in Somalia

This article attempts to answer how Burundi has become one of the main troop-contributing countries to international peacekeeping missions. To do this, it examines how the post-conflict political settlement between Burundian parties and external partners has impacted on the decision to deploy Burundian troops in multilateral peace operations in Africa. The authors claim that Burundi's decision to deploy troops, which took place in the midst of an overarching security sector reform, had a temporary stabilizing effect on the internal political balance due to several factors, including professionalization, prestige, and financial opportunities. From an international perspective, Burundi's role in peacekeeping has helped to reverse the image of Burundi as a post-conflict country in need of assistance to that of a peacebuilding state, offering assistance to others who are worse off. These factors taken together have also enhanced the possibilities for the Burundian Government to continue its trend of demanding...
La mémoire du passé. Les couvents dominicains des provinces d’Espagne et d’Aragon à travers les écrits de l’époque moderne1

La documentation dont l’historien de l’art du Moyen Âge dispose pour travailler sur les établissements de frères et de moniales de la famille dominicaine dans la péninsule Ibérique comprend de nombreuses sources datant de l’époque moderne. Une utilisation fine de cette documentation demande de se poser au préalable deux questions : 1) En quoi l’état décrit à l’époque moderne reflète-t-il les siècles précédents ? 2) Comment a été produite cette documentation, dans quel contexte et avec quelles finalités ? L’article dresse une typologie des sources modernes, manuscrites ou imprimées, produites à l’intérieur de l’ordre et utiles pour l’historien de l’art médiéval. Il s’attache à cerner les caractéristiques du regard des érudits dominicains sur leur patrimoine ancien. Si, en définitive, ces sources ne permettent que rarement d’approcher les bâtiments et œuvres mobiles dans leur dimension formelle, elles documentent en revanche très souvent les tombes ainsi que la topographie des pratiques liturgiques et dévotionnelles, comme l’illustrent plusieurs exemples ici développés.
IMPROVED MOLD BLOCK RETURN

A two stage mold block transfer station is used the exit of a moving mold tunnel to quickly move mold blocks to a clear position relative to the molded product. Once in the clear position the mold block is rotated and provided to a return drive moving the mold block back to the inlet of the moving mold tunnel. By moving the last mold block of the moving mold tunnel primarily away from the longitudinal axis of the mold tunnel less mold blocks are required. Various arrangements for moving of the mold blocks can be used achieve this advantage.
Drug repurposing for inhibiting pathogenic biofilms and potentiating the activity of antibiotics

Bacterial biofilms are closely associated with chronic infections, leading to much higher tolerance to antibiotics and treatment failures. New strategies for biofilm disruption are thus urgently required. Cyclic-di-GMP, a secondary messenger promoting biofilm formation, is a promising drug target. Only few compounds that reduce c-di-GMP levels and inhibit biofilms were identified so far, and most studies were conducted in vitro using standard medium and reference strains. In this project drugs will be repurposed for targeting c-di-GMP and biofilms to increase the antibiotic susceptibility of clinical Pseudomonas aeruginosa strains. Interdisciplinary approaches will be applied, combining next generation sequencing, gene expression pattern in synthetic sputum, protein structural modelling and computational drug docking, lung epithelial cell infection and murine model. This project will increase the accuracy of drug discovery based on c-di-GMP and significantly expand the skillset of an early career researcher with a strong background in the molecular mechanism of c-di-GMP pathway. The new knowledge in human cell culture and murine model obtained in this fellowship will be crucial for the researcher with a long-term interest in infection treatment. The host laboratory at Ghent University (UGent), a leading group in Europe investigating combination therapy against biofilms, offers an excellent atmosphere fostering both technical and transferable skills. The researcher will also benefit from the supervisor’s extensive research network and the numerous training programs provided by UGent to enhance the future career prospects. The research outputs will provide fresh insights into how genetic and environmental conditions influence c-di-GMP pathway (basic science) and how to select more appropriate compounds for biofilm treatment (applied science), and may also be subjected to clinical trials and attract industrial partners for wider applications.
The Use of Chemostats in Microbial Systems Biology

Cells regulate their rate of growth in response to signals from the external world. As the cell grows, diverse cellular processes must be coordinated including macromolecular synthesis, metabolism and ultimately, commitment to the cell division cycle. The chemostat, a method of experimentally controlling cell growth rate, provides a powerful means of systematically studying how growth rate impacts cellular processes - including gene expression and metabolism - and the regulatory networks that control the rate of cell growth. When maintained for hundreds of generations chemostats can be used to study adaptive evolution of microbes in environmental conditions that limit cell growth. We describe the principle of chemostat cultures, demonstrate their operation and provide examples of their various applications. Following a period of disuse after their introduction in the middle of the twentieth century, the convergence of genome-scale methodologies with a renewed interest in the regulation of cell growth and the molecular basis of adaptive evolution is stimulating a renaissance in the use of chemostats in biological research.
Early stage researchers educational program on factor viii immunogenicity

The development of anti-drug antibodies is the major complication of treatment with biotherapeutics. This is particularly true
of patients with haemophilia A (HA) who develop neutralizing antibodies to therapeutic factor VIII (FVIII) following
replacement therapy with exogenous pro-coagulant FVIII. The onset of neutralizing antibodies to FVIII, referred to as FVIII
inhibitors, represents a major societal concern owing to the enormous cost associated to the clinical management of
inhibitor-positive patients, that exceeds 200,000€/patient/year. The EDUC8 program is a multidisciplinary training program
with exposure of the enrolled ESRs to a core common educational package and development of individual PhD research
projects dedicated to decreasing the societal burden associated with the development of anti-FVIII antibodies in Europe. The
core educational program includes exposure to basic science in the fields of immunology and hemostasis, to the most
advanced “omic” technologies in order to anticipate tomorrow’s scientific discoveries, and to the importance of ethical
considerations and public awareness in today’s research. A key component of the training program is provided by immersion
of the ESRs in a clinical center for HA, which will provide them with a unique experience and foster the conception of novel
and realistic therapeutic approaches. The ESRs will exploit the accumulated theoretic and practical experience in an
entrepreneurship training on key strategic, technical, financial and human resource issues required for the creation of startups.
In a tribute to the concept of the fully developed mind coined by the French philosopher Michel de Montaigne on
education, our ambition is to form a novel generation of scientists with deep scientific knowledge, multicultural exposure,
imagination, pragmatism and understanding of both the academic and private sectors. This will foster translational research in European on the immunogenicity of therapeutic proteins.
Hidden continuous symmetry and Nambu-Goldstone mode in a two-mode Dicke model

In this paper we investigate the ground- and excited-state properties of a two-mode Dicke model, which is realized in an ensemble of many four-level atoms interacting simultaneously with two quantized cavity fields and two pairs of Raman lasers. We reveal rich phase diagrams, including a first-order quantum phase transition from an electric superradiant phase to a magnetic superradiant phase. In particular, when the two collective atom-photon coupling strengths are equal, we find a hidden continuous $\text{U}(1)$ symmetry for the two-mode Dicke model. If these identical coupling strengths are sufficiently strong, a quantum phase called the electromagnetic superradiant phase is predicted. In such a phase, the predicted continuous $\text{U}(1)$ symmetry breaks down and the gapless excitation spectrum (the Nambu-Goldstone mode), which could be measured experimentally by combining Bragg spectroscopy and cavity-enhanced Bragg scattering, is thus achieved. Our results pave the way to explore the physics for a model with continuous symmetry in quantum optics without using the rotating-wave approximation.
Industrialization and Sustainable Food Security: New Challenges for Malaysia

AbstractThis paper calls for a renewed analysis of industrial policies in light of recent threat to the food security agenda in Malaysia. In particular, three new challenges and their implications for food security policies are discussed. National strategies to promote economic liberalization since the 1980s undermine the development of sustainable food security agenda. These challenges include (1) realignment of national policies from agricultural based to industrial based, (2) conversion of agricultural land, and (3) increased imports of food. This paper argues that analysis on food security agenda highlights a fundamental contradiction at the heart of the industrial project. It contends that unless current agricultural policies are drastically reformed, traditional patterns of food insecurity will continue to pose a greater threat to sustainable food production in Malaysia. This paper concludes that strategic government intervention is required to promote food security in the country.KeywordsFood securityIndustrial policyFood productionSustainable development
Solution Structure of Multi-layer Neural Networks with Initial Condition

This paper studies the initial value problem of multi-layer cellular neural networks. We demonstrate that the mosaic solutions of such system is topologically conjugated to a new class in symbolic dynamical systems called the path set (Abram and Lagarias in Adv Appl Math 56:109–134, 2014). The topological entropies of the solution, output, and hidden spaces of a multi-layer cellular neural network with initial condition are formulated explicitly. Also, a sufficient condition for whether the mosaic solution space of a multi-layer cellular neural network is independent of initial conditions is addressed. Furthermore, two spaces exhibit identical topological entropy if and only if they are finitely equivalent.
VERTEBRATE STUDIES | Speciation and Evolutionary Trends in Quaternary Vertebrates

The Quaternary is an ideal interval in which to study the origin of vertebrate species and their adaptations in the fossil record. The time intervals available (10 2 –10 6 years) are of the order of magnitude at which such processes occur; there is a rich fossil record over a wide geographical area; and paleoenvironmental and dating studies allow us to put the evolving vertebrates into a chronological and ecological context. This article focuses on case histories of phenotypic evolution that can be traced through stratified sequences of fossils. Speciation can be seen in bears (origin of cave bear and polar bear), while adaptive transitions within and across species are seen in various lineages of rodents and in mammoths. A multiplicity of evolutionary modes is evident. Whether evolution accelerated in the Quaternary is still an open question. The integration of morphological and molecular studies offers particular potential for the future.
A BARRIER DELIMITING INFRASTRUCTURAL ZONES FROM A SURROUNDING ENVIRONMENT

The present invention relates to different embodiments of a delimiting barrier (1) for infrastructural zones from the surrounding environment for delimiting communication carriageways. In each embodiment, the barrier (1) comprises a plurality of plates, comprising a first plate (2) and a second plate (3), which are distributed along an extension direction (X) of the barrier (1) which are supported by corresponding support means (4), in the form of uprights (4) which are prolonged perpendicularly in height. The first plate (2) and the second plate (3) are fixed to a respective upright (40) by connecting means (5) and have respective end lateral portions (2a, 3a) reciprocally superposed in a transversal direction (Y) to the extension direction (X) of the barrier (1).
Implementation Framework for Energy Flexibility Technologies in Alkmaar and Évora

As energy generation based on renewable resources does not always match energy consumption profiles, Positive Energy Districts (PEDs) should embody energy flexibility technologies to decrease possible negative impacts on existing grids due to, e.g., reverse power flows. As part of the EU H2020 Smart Cities and Communities project POCITYF, the cities Alkmaar (NL) and Évora (PT) aim to support the deployment and market uptake of such districts and in doing so demonstrate innovative and integrated technologies to enable flexibility in the energy system. This paper addresses implementation conditions for energy flexibility technologies that help cities to engender the expected impact and ensure replication of these technologies to other sites. It aims to guide both urban planners and technology solution providers through pitfalls and opportunities that can appear during the design and implementation of PEDs. Taking this into consideration, the RUGGEDISED innovation and implementation framework for smart city technology was taken as a starting point to describe and analyze the experiences in Alkmaar and Évora.
CLIENT-ASSISTED MOTION ESTIMATION FOR CLIENT-SERVER VIDEO COMMUNICATION

A system and method for client-assisted motion estimation for the client-server video communication is disclosed. The present invention includes the steps of receiving a request to update a current set of pixels within a video display on a client computer, and generating a motion vector for moving the current set of pixels within the video display using video information obtained only from the request and the client computer. In addition to sets of pixels, the present invention operates as well on objects, blocks and frames of video information.
Sharing Solutions on Structural Funds

Regional and local authorities are increasingly involved in the elaboration and implementation of EU policies For instance, in EU regional policy they are involved in programming, managing, monitoring and evaluating Structural Funds programmes. To enhance institutional capacities and the success of authorities in dealing with Structural Funds, regions need to develop new ways to involve local stakeholders while at the same time keeping decision-making processes transparent and efficient. Regions also need to learn how to better communicate the objectives and goals of Structural Funds and create a sense of ownership of projects in the regions. Objectives The operation "S3 – Sharing solutions on Structural Funds" aims at transferring and further developing know-how and tools for the development and management of Structural Funds programmes. With a particular focus on bottom-up approaches through the involvement of local stakeholders, project partners want to create a strong and reliable network for the creation and dissemination of relevant know-how and tools to regional institutions, including those in the new member states. Results The operation enhances the capacities of partner institutions to implement and manage Structural Funds programmes. It increases the awareness of good practice in Structural Funds management among partners and stakeholders. Activities include analyzing and benchmarking of regional Structural Funds management skills as well as disseminating innovative and tested tools for programming and management. To disseminate lesions learned, partners conduct interregional study tours, workshops and conferences and exchange staff.
Hemozoin detection using nitrogen-vacancy centers in diamond

Advances in chemistry, biology and medicine have been historically promoted by physical tools, with notable examples x-ray crystallography, nuclear magnetic resonance spectroscopy and microscopy. A new physical tool has recently emerged as a unique electromagnetic-field sensor and it is based on the exploitation of the remarkable magneto-optic properties of one particular color center in diamond, known as the Nitrogen-Vanancy (NV) center. In recent years, nano-scale sensors using NV centers have enabled the detection of nanoscale ensembles of nuclear and/or electron spins, and high-resolution imaging of living cells, to name few of the most outstanding sensing demonstrations using NV centers. We propose the development and implementation of a high-throughput sensor utilizing NV centers in diamonds, for the sensitive, quantitative and rapid detection of ensembles of paramagnetic spins in liquids and crystals. Sensitive paramagnetic-spin sensors will enable the possibility for nanoscale sensing and imaging of the structure and electron configuration of biomolecules, and most importantly, of real-time observations of chemical and biological processes. The principal motivation for the proposed project is the implementation of the developed sensor for the detection of paramagnetic crystals, and in particular of synthetic hemozoin crystals. Synthetic hemozoin crystals have identical magneto-optic properties with naturally-grown hemozoin crystals, a byproduct of malaria infection. A label-free, high-throughput sensor of hemozoin crystals, with sensitivity limits better than the currently used malaria diagnostic techniques will pave the way for a new diagnostic tool that could be used for the early diagnosis of malaria, and therefore, contribute to the eradication of one of the deadliest diseases in the world.
METHOD FOR OPERATING A NOISE-EMITTING INSTALLATION AND INSTALLATION FOR PERFORMING THE METHOD

The invention relates to a method for operating a noise-emitting installation (11), which emits noise subject to noise protection provisions into the environment at specifiable times in the form of operationally determined noise events that each extend over a certain time period, the emission of noise being distributed over the day. Reliable noise protection is achieved in that the sound pressure level is continually recorded by means of at least one sound pressure sensor (M1-M10) in the noise-emitting installation (11), in that the recorded values of the sound pressure level are used to detect when and over what time period each noise event occurs, in that the sound pressure level occurring in the particular noise event is summed or integrated over the duration of the noise event, in that the summed or integrated sound pressure levels of consecutive noise events are summed to form a noise dose, and in that the resulting noise dose is continually compared with specified dose limit values and the operation of the installation (11) is controlled in accordance with the results of the comparison.
Trasformazione digitale di ELTRAS.

L'azienda ha una visione di una trasformazione integrata attraverso digi.transf. con l'obiettivo di aumentare la produttività, la competitività e la crescita dell'azienda.Strategie aziendali cilji:poveianje ricavi, aumento della capacità produttiva, aumento dei progetti di sviluppo,vefia innovazione, miglioramento dell'esperienza del cliente, introduzione di una produzione snella ed elementi di business agile, introduzione di industrue 4.0, ecc. sono disponibili solo con una società dig.transf. completa in tutte le sue aree di organizzazionezacue azienda (personale, cultura, technologua, modelli di business).
Metabolism of Ginseng and its Interactions with Drugs

Ginseng is an herbal medicine used worldwide. It is reported to have a wide range of pharmacological activities because of a diversified group of steroidal saponins called ginsenosides. Compared to extensive pharmacological studies of ginseng, the pharmacokinetics, especially the metabolism of this herb, has received less attention. In this article we review the known pharmacokinetic data on ginseng. Understanding ginseng's pharmacokinetics may reduce the potential for interactions in patients who use both ginseng and prescription medications. In addition, bioavailability after taking ginseng orally is low, and the metabolites of ginsenosides produced by gut microbiota may be biologically active. One ginseng metabolite, Compound K, and its potential for cancer chemoprevention is also discussed. An active ginseng metabolite may differ in distribution and clearance from its parent compound, and the parent compound and its metabolite may be bioactive by similar or different mechanisms. Thus, further investigation of ginseng metabolites is needed for predicting the therapeutic outcome with ginseng.