SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Rethinking climate change vulnerability:  drivers  patterns of thermal tolerance  adaptation in the ocean.

Climate change is having pervasive impacts on biota that is collectively resulting in a fundamental alteration of the structure, function and feedbacks within ecosystems across the globe. A major challenge for climate change science is to develop an understanding of the sensitivity of organisms to the changing environment, and try and find spatial, broad taxonomic or trait based generalities that will enable more accurate identification of regions and ecosystems at severe risk of climate change impacts (sensitivity hotspots) so that mitigation and adaptive management actions can be prioritised. There are, however, several challenges associated with predicting sensitivity hotspots. At the forefront of these challenges is our understanding of the drivers of organism’s thermal tolerance thresholds, and the proximity of temperature thresholds to the local climate extremes and climate change projections, herein called thermal safety margin (TSM). This project merges concepts from physiology, ecology, evolutionary biology, biogeography and physical oceanography into an interdisciplinary conceptual framework that exposes inconsistencies among current paradigms and fundamental limitations to our understanding of the sensitivity of marine organisms to climate change. The conceptual framework presented here offers a testable, interdisciplinary model to address this knowledge gap. Specifically we ask the questions 1) How do patterns in thermal tolerance breadth and thermal safety margins vary throughout species’ geographical ranges? And 2) What are the environmental drivers, biotic traits and evolutionary factors that determine an organisms thermal tolerance? Through identifying the nature of thermal tolerance patterns and identifying some of the mechanisms influencing these patterns, this research aims to increase the accuracy and resolution of predictions of the sensitivity of marine biota to climate change.
International phd programme for medical doctors

Addressing the increased need for innovative solutions in medicine and healthcare, as we are witnessing during the current worldwide pandemic, requires more than ever the rise of the unique professional profile of physician-scientists, combining cutting-edge research and technology with medicine. There are several MDPhD programmes in European countries and institutions, but there is none Europe-wide. The EMERALD International Doctoral Programme aims to nurture excellent physician-scientists to advance research, personalised medicine and health care in Europe. Following fair, merit-based, and inclusive recruitment, the programme will hire 24 medical doctors to carry out a PhD in cutting-edge research in seven European centres of excellence in life sciences and biomedicine. The EMERALD fellows will experience mobility across laboratories, sectors and countries, and they will benefit from international, stimulating and creative environments, advanced training, career development and mentoring programmes, and access to high-end technologies and facilities. Importantly, they will benefit from the advanced training on the latest technologies, digital skills, open science and innovation, and from the mentoring provided by the EMERALD programme, with the opportunity to build valuable international networks with different actors in academia, hospitals, industry, patients´ organisations and NGOs. EMERALD counts on the impressive support and collaboration of 37 partner organisations from 10 European countries. The trained physician-scientists will be equipped with skills and knowledge to tackle relevant clinical and research questions, bridging the gap between laboratory research and caring of patients, and ultimately pursuing new approaches to diagnose and treat human diseases.
SIPLID FOR A CONTAINER HAVING A TWISTING EFFECT, AND METHOD FOR MANUFACTURING SUCH SIPLID

The invention relates to a siplid 2, a container provided with such siplid and a method therefor. The siplid comprises: • - a container side 4, a consumer side 6, and a siplid plane 12 having a siplid axis 14; • - an edge 8 configured for surrounding a container opening to cover the container opening; • - a drinking opening 18 in the siplid having a length L substantially extending in the circumferential direction of the siplid, and having a width W substantially extending in the radial direction of the siplid; • - a moveable tab 20 configured for covering the opening in a closed position; • - a recess 22 configured for receiving the moveable tab in an open position; • - a hinge 32 configured for enabling rotational movement of the tab around a hinge axis; and • - a section line 16 extending in the siplid plane dividing the opening in two equal parts, and a division line 34 in between the opening and the recess extending substantially perpendicular to the section line wherein the hinge axis is provided at a lid angle to the division line.
Modulated optical energy source

An optical radiant energy source capable of far infrared spectrum operation and on-off energy modulation without interruption of the radiation sources operating temperature characteristics. Provisions for radiant energy dissipation as part of the modulation, for achieving uniform output beam dispersion over a specified area, and for airframe mounting of the disclosed apparatus are also included.
Effect of Specimen Coupling on the Torsional Resonant Column Test

The torsional resonant column is used to measure dynamic properties of soils. For this purpose, a sinusoidal torque is applied on a cylindrical specimen. The response of the specimen is used to derive the shear modulus and damping ratio of the specimen as functions of the induced shearing strain amplitude. The test interpretation assumes perfect coupling between the specimen and the end-platens. The main purpose of the present paper is to document the effects of specimen coupling on the interpreted properties of granular soils tested using several different coupling techniques. The granular specimens were prepared by raining granular soil in six layers into a mold. The soils consisted of angular and rounded sands and spherical glass beads. The coupling techniques included smooth end-plates, porous stone end-plates with and without embedded blades, and smooth end-plates coupled to the specimen with epoxy resin. The performance of the coupling was evaluated based on the relationship of the shear modulus and internal damping ratio with the shearing strain amplitude. The program included one relative density for each soil and one confining pressure. For each set of soil type and coupling technique, five repetitions were performed to illustrate test variability and provide statistical evidence of significant differences. The significance of the observed differences was based on the 95 % confidence interval of the mean response. The results showed significant differences among the interpreted soil properties depending on the coupling technique. The results from epoxy-coupled specimens were used as the reference and in general provided somewhat higher moduli and lower internal damping ratios. Particle size had small effects, but particle shape significantly affected the results, especially at high strain amplitudes. Existing suggestions in the literature of a threshold peak friction that would require special coupling techniques in order to test these soils were found to be excessively large.
A Study of Fan-Distortion Interaction Within the NASA Rotor 67 Transonic Stage

The performance of a transonic fan operating within nonuniform inlet flow remains a key concern for the design and operability of a turbofan engine. This paper applies computational methods to improve the understanding of the interaction between a transonic fan and an inlet total pressure distortion. The test case studied is the NASA rotor 67 stage operating with a total pressure distortion covering a 120-deg sector of the inlet flow field. Full-annulus, unsteady, three-dimensional CFD has been used to simulate the test rig installation and the full fan assembly operating with inlet distortion. Novel post-processing methods have been applied to extract the fan performance and features of the interaction between the fan and the nonuniform inflow. The results of the unsteady computations agree well with the measurement data. The local operating condition of the fan at different positions around the annulus has been tracked and analyzed, and this is shown to be highly dependent on the swirl and mass flow redistribution that the rotor induces ahead of it due to the incoming distortion. The upstream flow effects lead to a variation in work input that determines the distortion pattern seen downstream of the fan stage. In addition, the unsteady computations also reveal more complex flow features downstream of the fan stage, which arise due to the three dimensionality of the flow and unsteadiness.
Down-regulation of GRIM-19 is associated with STAT3 overexpression in breast carcinomas

To evaluate the association of gene associated with retinoic-interferon-induced mortality 19 (GRIM-19) with clinicopathologic features as well as its target gene signal transducer and activator of transcription 3 (STAT3) in patients with breast cancer, GRIM-19 and STAT3 expression was measured immunohistochemically in 108 breast samples and by Western blotting in 20 breast cancer tissues and corresponding nontumorous tissues. Expression of GRIM-19 was severely depressed in the carcinomas relative to matched nontumorous tissues (P < .001), and STAT3 was overexpressed in breast cancer tissues (P < .001), conclusions supported by Western blot analysis. Nonexpression of GRIM-19 was significantly associated with lymph node metastasis (P < .001), advanced tumor-node-metastasis stage (P = .02), and triple-negative phenotype (P = .03). Furthermore, down-regulation of GRIM-19 correlated with STAT3 overexpression (r = 0.56; P < .001). Thus, GRIM-19 is suppressed in primary breast carcinomas, with a corresponding increase in STAT3 activity.
Streptomyces jiujiangensis sp. nov., isolated from soil in South China

An actinomycete capable of lysing cyanobacteria, strain JXJ 0074(T), was isolated from a soil sample collected from Jiangxi province, south China, and characterized by using polyphasic taxonomy. The new isolate showed morphological and chemotaxonomic properties typical of members of the genus Streptomyces. Phylogenetic analysis of the near-complete 16S rRNA gene sequence indicated that strain JXJ 0074(T) should be affiliated to the genus Streptomyces and exhibited highest similarities to Streptomyces shenzhenensis DSM 42034(T) (98.99 %) and Streptomyces lucensis NBRC 13056(T) (98.60 %), while the similarities to other members of the genus are lower than 98.22 % similarity. However, the DNA-DNA hybridization values between strain JXJ 0074(T) and S. shenzhenensis DSM 42034(T) or S. lucensis NBRC 13056(T) were 46.2 ± 2.6 and 32.6 ± 3.1 %, respectively. Thus, on the basis of the polyphasic data, strain JXJ 0074(T) represents a novel species of the genus Streptomyces, for which the name Streptomyces jiujiangensis sp. nov. is proposed. The type strain is JXJ 0074(T) (= BCRC 16953(T) = KCTC 29262(T)).
LATERAL GLAZING OF A MEANS OF TRANSPORT TO BE FIXED FROM THE OUTSIDE

The invention relates to a lateral glazing (1) of a means of transport, particularly to a tramway glazing, said glazing comprising a mounting plate (20) having a through-hole (24) opening at the exterior face (21) and at the interior face (22) of the mounting plate (20) and a glazed element (10) having at least one through-hole (14) opening at the exterior face (11) and at the interior face (12) of the glazed element (10), said hole (14) of the glazed element (10) being coaxial with said hole (24) of said mounting plate (20).
Mannan-Related enzymes of wheat endosperm

European society and economy relies on the productivity of staple food, such as wheat. Plant cell walls are a centrepiece of plant development and tuning their biosynthesis could improve the productivity and the quality of wheat grain. Although the structure of cell wall polysaccharides is relatively well-documented, little is known about their biosynthesis. The project proposes for the first time 1) to explore the structure, organisation and function of mannan, a cell wall polysaccharide that impacts on wheat grain development, and 2) to investigate the function of four putative genes involved in the mannan biosynthesis, using a combination of well established and new methodologies (enzymatic fingerprinting, FT-IR microspectroscopy and MALDI-MS imaging). This research is of potential interest to various industrial sectors (e.g., plant breeding, milling and biofuel industries) active in Europe and represents a good opportunity to improve competitiveness of European agriculture. Within the host institute (INRA, France), which is a World leader for agricultural sciences, the supervisor is internationally renowned for its contribution in the general understanding of plant cell walls. The host will offer the opportunity to the fellow to develop a sound knowledge in biochemistry and molecular biology and will contribute to improve his managerial skills. In return, the fellow who has a strong expertise in microscopy and enzymatic activity assays will implement these techniques in the host institution. The fellow will have the opportunity to disseminate his knowledge during various events towards audiences of scientists, students and the general public. The fellow will access to all the facilities, logistics, and equipment necessary for the good implementation of his project. In summary, this innovative project will contribute to European excellence and will offer the training the fellow needs to pursue his career as an independent principal investigator in plant science.
PRESS PAD FOR A PRESS PUNCH OF A LAUNDRY PRESS WITH SWELLABLE SEALING ELEMENT

The present invention relates to a press pad (1) for a press punch of a laundry press comprising at least one sealing element (16a, 16b) for the liquid sealing of the press pad (1) relative to at least one other component of the laundry press, wherein the sealing element (16a, 16b) is designed to enlarge the volume thereof upon contact with liquids.
Peristaltic multistage micro-mechanical pump for next generation diabetes management

More than 30 million people are living with diabetes in the EU, with a prevalence expected to grow to over 10% of the adult population by the year 2030. Despite modern treatments, the life expectancy of patients with type 1 diabetes remains reduced as compared to healthy people due to lack of efficient therapies. An “artificial pancreas” is the ultimate solution for such therapy: a device performing a continuous glucose measurement and pumping precise doses of insulin and other hormones needed for the treatment. The closed-loop artificial pancreases promises an agile solution where the diabetes patients may effectively feel relieved from their disease as the blood glucose level is automatically controlled using a mixture of multiple hormones simultaneously. Such an innovative technology alleviates the burden of carbohydrate counting and automatically ensuring the optimal glucose level at all times. However, a small, lightweight device which is able to administrate multiple hormones is still lacking. This proposal seeks to develop a novel micro-peristaltic pump on silicon, to be integrated with a transdermal smart patch loaded with the three hormones delivered by silicon microneedles. The PRISMA innovation is possible thanks to the achievements of the FET-OPEN project “BioWings”, where the concept of thin-film micropump using actuating materials has been prototyped.
Navigator and global interface applications for visually impaired people using galileo satellite technologies

The objective of VOICEGALILEO is to create a new set of solutions (a stand-alone, portable and user-friendly device and 2 apps) for Visually Impaired People (VIPs) that will enable them to find their ways in urban areas with a precision of 1 meter, when Galileo will be fully operational. 
In order to achieve its final objective, VOICEGALILEO will: 
- exploit satellite navigation technologies and integrate them with accelerometer, odometer, digital compass as well as with mobile phone technologies and Bluetooth in areas where the satellite is not available (it combats the “canyon effect” – tall buildings blocking satellite outdoor, as well as the lack of satellite signals indoor or underground);
- interact with information generated by a number of data providers so that VIPs will be able to find their way in urban areas (including support while they move from one point to the other), but also browse valuable information related to public transportation, cultural sites, special events, restaurants, shops, etc. 
Intermediate steps will consist in: 
- the update of an ad hoc software called VoiceGPS that had been developed and successfully tested by our Company in 2003; the software will also serve as basis for the development of the apps (running on both Android and Apple environments);
- its integration with a personal monitor for VIPs (with a braille keyboard and vocal synthesizer to maximize interaction with VIPs) and the testing of the device so to create a standalone solution. 
Final output will be the marketization of the stand-alone, portable and user-friendly device for VIPs as well as two apps available for mobile devices (in Android and Apple environments) that exploit EGNOS technology and Galileo.
Objectives of the feasibility study include the elaboration of a specific business plan, the individuation of suitable partners among European SMEs, the definition of Intellectual Property management issues as well as the development of the innovation strategy.
LOW-GEAR SYSTEM FOR MANUALLY PROPELLED WHEELCHAIRS AND METHODS OF USE

A low-gear drive system functionally coupled to a wheelchair is provided herein.
Alterations of GABAA and glutamate receptor subunits and heat shock protein in rat hippocampus following traumatic brain injury and in posttraumatic epilepsy

Traumatic brain injury (TBI) can result in the development of posttraumatic epilepsy (PTE). Recently, we reported differential alterations in tonic and phasic GABA(A) receptor (GABA(A)R) currents in hippocampal dentate granule cells 90 days after controlled cortical impact (CCI) (Mtchedlishvili et al., 2010). In the present study, we investigated long-term changes in the protein expression of GABA(A)R α1, α4, γ2, and δ subunits, NMDA (NR2B) and AMPA (GluR1) receptor subunits, and heat shock proteins (HSP70 and HSP90) in the hippocampus of Sprague-Dawley rats evaluated by Western blotting in controls, CCI-injured animals without PTE (CCI group), and CCI-injured animals with PTE (PTE group). No differences were found among all three groups for α1 and α4 subunits. Significant reduction of γ2 protein was observed in the PTE group compared to control. CCI caused a 194% and 127% increase of δ protein in the CCI group compared to control (p<0.0001), and PTE (p<0.0001) groups, respectively. NR2B protein was increased in CCI and PTE groups compared to control (p=0.0001, and p=0.011, respectively). GluR1 protein was significantly decreased in CCI and PTE groups compared to control (p=0.003, and p=0.001, respectively), and in the PTE group compared to the CCI group (p=0.036). HSP70 was increased in CCI and PTE groups compared to control (p=0.014, and p=0.005, respectively); no changes were found in HSP90 expression. These results provide for the first time evidence of long-term alterations of GABA(A) and glutamate receptor subunits and a HSP following CCI.
A phase I study of the human monoclonal anti-NRP1 antibody MNRP1685A in patients with advanced solid tumors

The human monoclonal antibody MNRP1685A targets the VEGF binding domain of neuropilin-1 (NRP1), a multi-domain receptor necessary for neural development and blood vessel maturation. In nonclinical studies, MNRP1685A prevents vascular maturation by keeping blood vessels in an immature, highly VEGF-dependent state. We explored the safety and tolerability of MNRP1685A in patients with advanced solid tumors. Patients were treated with MNRP1685A given intravenously every 3 weeks using a 3 + 3 dose-escalation design with 7 dose-escalation cohorts. Twenty-four of 35 patients (69 %) experienced drug-related adverse events (AEs) of infusion-related reaction on the day of MNRP1685A administration. With premedication including dexamethasone, infusions were well-tolerated with main symptoms of pruritus and rash. Outside the day of infusion, most common (≥ 2 patients) related AEs were fatigue (17 %), pruritus (9 %), myalgia and thrombocytopenia (both 6 %) (all were Grade 1-2). MNRP1685A-related Grade ≥ 3 AEs consisted of one dose-limiting toxicity of Grade 3 upper gastrointestinal bleeding and one related Grade 3 thrombocytopenia, coinciding with unrelated Grade 3 fungemia and duodenal obstruction. MNRP1685A showed nonlinear PK with more-than-dose proportional increases in exposure, consistent with broad target expression. Transient platelet count reductions (≥ 30 % from predose) were observed in 56 % of evaluable patients. Nine patients were on study for ≥ 4 cycles, one colorectal cancer patient for one year. MNRP1685A was generally well-tolerated. The primary MNRP1685A-related AE was infusion-related reaction, which were attenuated by premedication including dexamethasone. Transient platelet count reductions were frequent but did not impact MNRP1685A dosing.
Development of Electronic and Electrical Materials from Indian Ilmenite

Some new complex electronic materials have been prepared by mixing bismuth oxide (Bi2O3) and ilmenite in different proportions by weight, using a mixed-oxide technique. Room-temperature x-ray diffraction analysis confirms the formation of a new compound with trigonal (rhombohedral) crystal structure with some secondary phases. Studies of dielectric parameters (er and tan δ) of these compounds as a function of temperature at different frequencies show that they are almost temperature independent in the low-temperature range. They possess high dielectric constant and relatively small tangent loss even in the high-temperature range. Detailed studies of impedance and related parameters show that the electrical properties of these materials are strongly dependent on temperature, showing good correlation with their microstructures. The bulk resistance, evaluated from complex impedance spectra, is found to decrease with increasing temperature. Thus, these materials show negative temperature coefficient of resistance (NTCR)-type behavior similar to that of semiconductors. The same has also been observed from their I–V characteristics. Complex electric modulus analysis indicates the possibility of a hopping conduction mechanism in these systems with nonexponential-type conductivity relaxation. The nature of the variation of the direct-current (dc) conductivity with temperature confirms the Arrhenius behavior of these materials. The alternating-current (ac) conductivity spectra show a typical signature of an ionic conducting system, and are found to obey Jonscher’s universal power law.
AMPLIFIER WITH ADAPTABLE FEEDBACK

An amplifier (3) for amplifying an electrical input signal (Vin) is provided. This amplifier (3) comprises at least one amplifier stage (31, 32, 33) and at least one feedback loop (34, 35, 36), which comprises a variable feedback loop element (37, 38, 39). Each feedback loop (34, 35, 36) is adapted to feed back a feedback signal from an output of the at least one amplifier stage (31, 32, 33) to an earlier stage of amplification within the amplifier (3). Each feedback loop (34, 35, 36) therein has a time constant. Said time constant has a first value during a first operation mode. Moreover, the amplifier (3) comprises a time constant modifier (40), which is adapted to modify a value of the variable feedback loop element (37, 38, 39), thereby modifying the time constant of the at least one feedback loop (34, 35, 36) to a second value, during a second operation mode.