SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Progressing Service Performance and Export Results of Advanced Manufacturers Networks

To strengthen advanced manufacturers is a key pillar of many RIS3-strategies in CE. In a globalised world espec. SMEs are facing competitive pressure and adding industrial services is a key factor for corporate value and global competitiveness. The path for manufacturers offering additional services (e.g. maintenance) is called servitization and requires big changes within enterprises – espec. if exporting the services. Difficulties occure because cultural, infrastructural and local service knowledge of target markets is crucial for success. Because of missing resources to get needed know-how, many SMEs have not yet reached levels of sufficiency within this development. By building a transnational network and using a bottom-up approach to collect experience from local level wide-ranging knowledge of exporting industrial services will be established in CE, where manufacturing is one of the most important industries. The project jointly develops innovative tools and approaches for supporting advanced manufacturers. Those tools help to identify internal leverages for improving the sale of industrial services and recognizing which service can be exported successfully. By providing advice and showing internationally operating good practice SMEs in a networking tableau advanced manufacturers will be supported. Business support organizations are trained to generate expert hubs for improving advanced manufacturers’ service export performance. Policy makers receive strategic action plans and recommendations for future opportunities i.e. what measures to set to change the decisive leverages locally. By using artificial intelligence to feed the developed tools, innovative technologies are used and a sustainable currency of provided information is guaranteed. PROSPER aims at a triple helix approach by linking various stakeholders. This contributes to innovative and efficient solutions for regional needs according RIS3 for all target groups in the field of industrial services.
Realising the transition to the circular economy: models, methods and applications

This network brings together an exceptionally strong team of world-leading experts from a wide set of beneficiaries and partners in order to achieve breakthroughs in understanding how the transition towards a Circular Economy (CE) can be realised in a successful way in the European context, both within existing organisations and industries as well as through innovative and sustainable business models. The proposed approach is inherently multi-disciplinary, drawing upon research that will advance significantly the state-of-the-art in terms of the current understanding of the applicability of the CE paradigm from Economic, Environmental and Social points of view, providing policy insights and implications for practice. The consortium of 10 beneficiaries (including 7 academic and 3 non-academic groups) will design and deliver world class multidisciplinary training to 15 Early Stage Researchers (ESRs), offering them an extended and valuable program of international exchanges and secondments through the wide network of partner organisations involved in the proposal. The network builds on the success of previous projects in which beneficiaries have successfully delivered high impact research and knowledge exchange. ReTraCE is specifically designed to train a cohort of new thought leaders capable of driving the transition towards a more sustainable mode of production and consumption in Europe in the next decades, who will directly facilitate the implementation of the recently adopted ambitious Circular Economy strategy of the European Commission, which is closely linked to Sustainable Development Goals (SDGs). Indeed, it is envisaged that ESRs will be employable not only by research institutions, but also by public sector bodies and within a wide range of manufacturing and service industries which will require new professional profiles for realising the transition towards the CE.
Enhancing the efficiency of crude oil transportation pipeline: a novel approach

In this paper, exergy and economic analyses are carried out on a 30″ crude oil transportation pipeline and related pump stations. The exergy destructions and losses of the components and the entire system were determined in the operation, resulting in the identification of the gas turbines stacks as the major elements of exergy losses. A proposal has been made for improving the energy and exergy efficiencies of the entire system. It has been shown that transfer of heat recovered from hot flue gas to the crude oil (for warming up the crude oil) can reduce the viscosity and flow resistance of the crude oil in the transportation pipelines, which could lead to a reduction in the power consumption and transportation costs. By applying this method, the energy and exergy efficiencies of the system will increase by up to 36.40 and 23.23%, respectively.
Australia suspends seasonal flu vaccination of young children

Australia has extended a suspension of vaccination of children aged 5 years and under against seasonal flu, pending further investigations into an apparent spike in febrile convulsions associated with the vaccine.

A temporary suspension was first announced on 23 April, after concerns emerged in Western Australia about an increase in the number of young children presenting to hospitals with febrile convulsion after receiving the trivalent seasonal flu vaccine.

The federal government’s chief medical officer, Jim Bishop, announced on 30 April that more time was needed to complete epidemiological and scientific investigations.

“Given the ongoing and incomplete scientific and clinical case review, the moratorium on the use of seasonal influenza vaccine in children 5 years and less will continue,” he said.

Figures released by the national Department of Health and Ageing show that 77 cases of febrile convulsion in children aged 5 or under and associated with the vaccination have recently been reported to the Therapeutic Goods …
Differential regulation of bladder cancer growth by various glucocorticoids: corticosterone and prednisone inhibit cell invasion without promoting cell proliferation or reducing cisplatin cytotoxicity

A synthetic glucocorticoid, dexamethasone, was recently shown to inhibit bladder cancer cell invasion and metastasis through the glucocorticoid receptor (GR) pathway but increased cell proliferation via inhibiting apoptosis particularly induced by cisplatin. Therefore, comedication with dexamethasone in bladder cancer patients may lead to unfavorable outcomes such as chemoresistance. We here look for any glucocorticoids with inhibitory effects on tumor cell invasion yet inhibitory or at least no stimulatory effects on cell viability.The effects of 10 glucocorticoids on cell viability were first assessed in three bladder cancer lines. Selected compounds were further assessed for their ability in cell viability and apoptosis, with or without cisplatin, as well as in cell invasion.Most of the compounds (hydrocortisone, betamethasone, flumethasone, triamcinolone, budesonide, fluticasone propionate, and fludrocortisone acetate) increased GR-positive cell growth, which was similar to or even stronger than the effect of dexamethasone. Nonetheless, two glucocorticoids (corticosterone, prednisone) showed only marginal effects on cell growth of all the lines tested. They did not significantly reduce the effects of cisplatin on cell proliferation or cisplatin-induced apoptosis. Conversely, corticosterone, prednisone, and dexamethasone similarly inhibited cell invasion and expression of related genes, including MMP-9, VEGF, and IL-6, in GR-positive lines.Corticosterone and prednisone are suggested to have the potential of being harmless, in contrast to dexamethasone, without promoting cell proliferation or inhibiting cytotoxic activity of cisplatin, yet beneficial to bladder cancer patients via suppressing tumor invasion. Our results are thus useful in improving chemotherapy regimens, including optimal glucocorticoids, for urothelial carcinoma.
Chitosan Application for Treatment of Beni-Amrane's Water Dam

Abstract Chitosan is a biopolymer, biodegradable, non-toxic and widely abundant in nature. Our study presents an investigation on the application of this biopolymer in treatment of Beni- Amrane dam water by coagulation flocculation process. In this study, the raw water from Beni-Amrane dam characterized by high turbidity was treated using chitosan as primary flocculant and as coagulant aid with aluminum sulfate (alum). The performance of this process was evaluated by measuring the supernatant residual turbidity for various values of chitosan concentrations. The obtained results are in favor of chitosan. With low concentrations, chitosane used alone is able to reducing 85% of initial turbidity. In the case of using chitosane in combination with alum, highest turbidity removal (97%) was carried out with 0. 15 mg/l of chitosan and 20 mg/l after 45 minutes of settling time. At this value, a very low residual aluminum (0, 02 mg/l) was registered. The organic carbon contribution on the turbidity coagulation flocculation performance is negligible because chitosan is used in small doses. Hence, chitosan could be used as natural coagulant aid for drinking water treatment with lowest risks of organic release. These properties, combined with its non-toxicity, make the chitosan as the best substitute to conventional synthetic polyelectrolytes used so far.
Crystal structure, dielectric properties of (K0.5Na0.5)NbO3single crystal grown by flux method using B2O3flux

Lead free piezoelectric single crystals of sodium potassium niobate (K0.5Na0.5)NbO3 (KNN) were grown by high-temperature solution method using two different fluxes; one with a mixture of NaF and KF and other with addition of B2O3 along with the mixture. In the present study, the growth of KNN crystals without B2O3 flux and the same with B2O3 flux were compared. It was found that additions of small amounts of B2O3 lowered the melting temperature of the solid solution and enabled better dielectric properties. Phase analysis showed that all samples were crystallized in pure orthorhombic perovskite phase. AFM morphological studies showed that the addition of B2O3 flux increased the roughness of the grown crystal. Further, addition of B2O3 flux slightly decreased the orthorhombic to tetragonal phase transition temperature T(O—T) and the Curie temperature TC. The ferroelectric behaviour of KNN single crystal has been investigated at room temperature. The crystal grown using B2O3 flux exhibited a remanent polarization (Pr) ∼ 32 μC/cm2 and coercive field (Ec) of ∼11.8 kV/cm whereas the crystal grown without the use of B2O3 flux had a remanent polarization (Pr) ∼ 36 μC/cm2 and coercive field (Ec) of ∼14.6 kV/cm.
The Rise of A Habitable Planet: Four Required Conditions for the Origin of Life in the Universe

The advanced version of the author’s inversion concept of the origin of terrestrial life and its application for life in the Universe has been substantiated. A key step in the transition to life consists in the thermodynamic inversion of non-living prebiotic microsystems when the contributions of free energy (F) and information (I) become prevalent over the contribution of entropy (S). It is based the thermodynamic corridor that is mandatory for all chemical scenarios for the origin of life: F + I &lt; S (prebiotic microsystem) → F + I ≈ S (intermediate stage, inversion moment) → F + I &gt; S (primary living unit). A prebiotic organic microsystem can reach the intermediate state between non-life and life only under high-frequency and multilevel oscillations of physic-chemical parameters in hydrothermal environments. The oscillations are considered the fourth required condition for the origin of life, in addition to the three well-known ones: the availability of organic matter, an aqueous medium, and a source of energy. The emergence of initial life sparks in nonequilibrium prebiotic microsystems (being at the intermediate state) proceeds through the continuous response (counteraction) of prebiotic microsystems to incessant physic-chemical oscillations (stress). The next step of laboratory simulations on the origin of life directed to the exploration of the microsystems’ response to high-frequency oscillations (&gt;10−10 s–&lt;30 min) is proposed. Finally, some fragments of the general scenario of the origin of life in the Universe based on the whole four required conditions have been outlined.
Endogenizing the provision of money: Costs of commodity and fiat monies in relation to the value of trade

a b s t r a c t We consider the problem of including the costs and value of the institutions that define money and support trade, within the framework of economic optimization. We compare monetary systems mediated by durable commodity monies, versus pure fiat monies, in order to understand the separation and eventual independence of the institutionally-created value of money from the values of underlying traded goods. We treat the emergence of monetary function as a problem in mechanism design, modeled by minimal strategic market games that overcome a generalized Jevons failure when agents must commit ahead of time to specialist resource production. We consider in particular the problem of defining closures with respect to both money flows and labor-allocation and trading decisions, and show that minimal models require many of the fundamental institutions of banking and contract enforcement found in real economies, in order to define a self-policing system. We define costs, value, and the efficiencies of the institutions that support trade in terms of a natural money-metric welfare function, and compare the characteristics of commodity and fiat monies by these measures. Through careful treatment of the stock/flow distinction in repeated-game settings, we find that commodity money, even when its value derives heavily from its institutional role, remains defined by its flow characteristics, in contrast to fiat money, for which the control function is defined inherently in terms of stock variables. Our notation is somewhat nonconventional for economics but to do justice to econo-physics concepts such as scaling and dimensional analysis and to stress the distinction between stocks and flows, we believe this notation is justified. We provide a full listing of notation in Appendix A.
Interdependencies of aortic arch secondary flow patterns, geometry, and age analysed by 4-dimensional phase contrast magnetic resonance imaging at 3 Tesla

ObjectiveIt was the aim to analyse the impact of age, aortic arch geometry, and size on secondary flow patterns such as helix and vortex flow derived from flow-sensitive magnetic resonance imaging (4D PC-MRI).Methods62 subjects (age range = 20–80 years) without circumscribed pathologies of the thoracic aorta (ascending aortic (AAo) diameter: 3.2 ± 0.6 cm [range 2.2–5.1]) were examined by 4D PC-MRI after IRB-approval and written informed consent. Blood flow visualisation based on streamlines and time-resolved 3D particle traces was performed. Aortic diameter, shape (gothic, crook-shaped, cubic), angle, and age were correlated with existence and extent of secondary flow patterns (helicity, vortices); statistical modelling was performed.ResultsHelical flow was the typical pattern in standard crook-shaped aortic arches. With altered shapes and increasing age, helicity was less common. AAo diameter and age had the highest correlation (r = 0.69 and 0.68, respectively) with number of detected vortices. None of the other arch geometric or demographic variables (for all, P ≥ 0.177) improved statistical modelling.ConclusionSubstantially different secondary flow patterns can be observed in the normal thoracic aorta. Age and the AAo diameter were the parameters correlating best with presence and amount of vortices. Findings underline the importance of age- and geometry-matched control groups for haemodynamic studies.Key Points• Secondary blood flow patterns (helices, vortices) are commonly observed in the aorta • Secondary flow patterns predominantly depend on patient age and aortic diameter • Geometric factors show a lesser impact on blood flow patterns than age and diameter • Future analyses of flow patterns should incorporate age- and diameter dependencies
Extending the relationship between global warming and cumulative carbon emissions to multi-millennial timescales

The transient climate response to cumulative carbon emissions (TCRE) is a highly policy-relevant quantity in climate science. The TCRE suggests that peak warming is linearly proportional to cumulative carbon emissions and nearly independent of the emissions scenario. Here, we use simulations of the Earth System Model (ESM) from the Geophysical Fluid Dynamics Laboratory (GFDL) to show that global mean surface temperature may increase by 0.5 °C after carbon emissions are stopped at 2 °C global warming, implying an increase in the coefficient relating global warming to cumulative carbon emissions on multi-centennial timescales. The simulations also suggest a 20% lower quota on cumulative carbon emissions allowed to achieve a policy-driven limit on global warming. ESM estimates from the Coupled Model Intercomparison Project Phase 5 (CMIP5–ESMs) qualitatively agree on this result, whereas Earth System Models of Intermediate Complexity (EMICs) simulations, used in the IPCC 5th assessment report to assess the robustness of TCRE on multi-centennial timescales, suggest a post-emissions decrease in temperature. The reason for this discrepancy lies in the smaller simulated realized warming fraction in CMIP5–ESMs, including GFDL ESM2M, than in EMICs when carbon emissions increase. The temperature response to cumulative carbon emissions can be characterized by three different phases and the linear TCRE framework is only valid during the first phase when carbon emissions increase. For longer timescales, when emissions tape off, two new metrics are introduced that better characterize the time-dependent temperature response to cumulative carbon emissions: the equilibrium climate response to cumulative carbon emissions and the multi-millennial climate response to cumulative carbon emissions.
Voices of belonging: minority identities, language and education in the netherlands

Youth radicalization is potential triggered by a sense of disconnect from society, and experiences of belonging carry important implications for youth identity formation. Language ideologies, policies, and practices in educational contexts send messages for youth regarding their belonging and/or value in society: the voices heard by youth. In addition, youth communicate their sense of belonging and the belonging of others through their words and actions, including their language choices and social affiliations: the voices of youth. The languages used and preferred by youth may or may not correlate with their educational achievement and identity positions. To illuminate the role of language and education in the development of a sense of belonging by youth in culturally and linguistically diverse contexts, this study is based at a large multicultural school in The Hague and addresses, first, how youth experience, enact, and define a sense of belonging and/or exclusion in their linguistic and educational contexts, second, how the language skills, language use choices, and linguistic affiliations of youth intersect with their educational achievements and sense of belonging, and third, the role of gender and ethnicity in the intersecting influences of language, education, and identity for youth in ethnically and linguistically diverse contexts. These questions are addressed through three stages of research: initial observation as vital for contextual depth and adaptation of appropriate questions, a questionnaire to quantitatively evaluate correlations among language, education, and identity, and a final in-depth stage providing student perspectives and supporting the interpretation of the findings. A broader objective of this research is to inform policies and educational programs that serve ethnically and linguistically diverse youth, providing foundations for the development of more culturally responsive pedagogy in the Netherlands and throughout Europe.
Road and rail tunnel fire protection

Fire in tunnels is a worldwide problem that leads to disasters with infrastructural challenges and huge economic and human losses as a result. In spite of all efforts to control and prevent human errors, and to detect technical problems, accidents will occur, and without efficient fire extinguishing capability, some of these accidents will develop into catastrophes. The amount of smoke and the extreme temperatures developed in tunnel fires prohibits fire fighters and rescue workers to reach the burning objects to save the trapped people. Damage to the structure with subsequent closure of the tunnel often leads to challenges for infrastructure and societal costs.

Fireproofing of tunnels has been discussed for years, but a method that effectively extinguishes any fire, reduces smoke to secure safe evacuation and reduce the damage on the structure, has to this date not been applied.

Fire Eater is a specialist in a fire extinguishing solution that can extinguish fire anywhere inside an enclosure. It has proven safe and efficient in applications as airports, Off-Shore, power generation and distribution, datacentres, warehouses with mixed goods and chemicals, cable tunnels and much more. Fire Eater has developed the basic engineering solution to apply our method to tunnels. Only recently it has been possible to locate a full size tunnel available to do the required testing and demonstration.

The highly innovative element in the application is the transfer of a proven technology to an entirely new area of use: rail and road tunnels.  When proven successful in full scale it will not only represent an interesting business opportunity, but also enable the creation of new standards for tunnel fire safety. 

The purpose of the project is a detailed feasibility study, to plan and engineer the test programme, to define acceptance criteria with the customer, and to search for consortium partners needed to supply the complete system package needed in this market.
Antitumor Activity of Cell-Permeable p18INK4c With Enhanced Membrane and Tissue Penetration

Practical methods to deliver proteins systemically in animals have been hampered by poor tissue penetration and inefficient cytoplasmic localization of internalized proteins. We therefore pursued the development of improved macromolecule transduction domains (MTDs) and tested their ability to deliver therapeutically active p18(INK4c). MTD103 was identified from a screen of 1,500 signal peptides; tested for the ability to promote protein uptake by cells and tissues; and analyzed with regard to the mechanism of protein uptake and the delivery of biologically active p18(INK4c) into cancer cells. The therapeutic potential of cell-permeable MTD103p18(INK4c) (CP-p18(INK4c)) was tested in the HCT116 tumor xenograft model. MTD103p18(INK4c) appeared to traverse plasma membranes directly, was transferred from cell-to-cell and was therapeutically effective against cancer xenografts, inhibiting tumor growth by 86-98% after 5 weeks (P < 0.05). The therapeutic responses to CP-p18(INK4c) were accompanied by high levels of apoptosis in tumor cells. In addition to enhancing systemic delivery of CP-p18(INK4c) to normal tissues and cancer xenografts, the MTD103 sequence delayed protein clearance from the blood, liver and spleen. These results demonstrate that macromolecule intracellular transduction technology (MITT), enabled by MTDs, may provide novel protein therapies against cancer and other diseases.