SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
In vitro antifungal activity of baicalin against Candida albicans biofilms via apoptotic induction

The aim of this study was to investigate the antifungal activity of baicalin and its potential mechanism of action against Candida albicans biofilms. The standard techniques including microdilution method and checkerboard assay were employed to evaluate the susceptibilities of baicalin alone and in combination with fluconazole against planktonic and biofilm cells of C. albicans. Transmission electron microscope (TEM), scanning electron microscope (SEM), fluorescent microscope and flow cytometry were used to assess the apoptotic incidences induced by baicalin in biofilm cells. The expressions of four genes (RAS1, CAP1, PDE2 and TPK1) related to Ras-cAMP-PKA pathway were also analyzed by quantitative reverse transcription polymerase chain reaction (qRT-PCR). The results showed that minimum inhibitory concentration (MIC) and sessile minimum inhibitory concentration (SMIC50) of baicalin were 500 and 2000 μg/mL with fractional inhibitory concentration indexs (FICIs) ranging from 0.28 to 0.75. A series of events related to apoptosis were observed in baicalin-treated C. albicans biofilms, including extensive chromatin condensation along the nuclear envelope, ROS accumulation, MMP reduction, PS externalization, nuclear fragmentation, chromatin condensation, metacaspase activation and Cyt C release. Additionally, the expressions of RAS1 and TPK1 were up-regulated by 3.2 and 2.9 folds respectively, while those of CAP1 and PDE2 were down-regulated by 3.3 and 6.6 folds respectively after exposure to baicalin in biofilm cells. In conclusion, baicalin can suppress the development of C. albicans biofilms most likely due to inducing cell death via apoptosis.
Reversible creation of non-inherent reactivity patterns in catalytic organic synthesis

Current methods in organic synthesis only enable reactions at the most reactive bonds or at bonds predisposed by specific directing groups. Consequently, many less reactive bonds, including numerous C-H and C-C bonds, cannot be functionalized, enormously limiting the scope of possible transformations. To overcome these limitations, I propose Reverse&Cat, a revolutionary strategy using a novel method to change the reactivity pattern of molecules. This strategy combines the dynamic equilibrium mediated by the first catalyst and a functionalization reaction catalyzed by the second catalyst. The originality of the transformation stems from exploiting three simultaneous processes: (i) the dynamic exchange of one functional group (FG) for another FG that modulates the reactivity of the substrate; (ii) the functionalization of the temporarily activated bond; and (iii) the restoration of the initial FG. In essence, the processes (i) and (iii) – the components of the dynamic equilibrium – realize the novel concept of the temporary creation of non-inherent reactivity of a substrate.
The program is divided in three phases, which will establish the full potential of the strategy. In phase A, I will develop a set of new reactions enabled by the bi-catalytic systems. I will exploit two types of reversible reactions: (1) reversible oxidation of alcohols, which delivers temporarily activated aldehydes/ketones, with the distinct reactivity of their C-H bonds; and (2) reversible retro-hydrofunctionalization of nitriles or their analogues, which delivers temporarily activated alkenes, containing allylic C-H and C=C bonds. In phase B, I will conduct detailed mechanistic studies to gain the mechanistic understanding and enable further rational development. In phase C, I will establish the utility of this new strategy in practical organic synthesis. Overall, the strategy will open a new dimension of reactivity, with prospective applications in production of fine-chemicals and materials.
Solvated ions in solid electrodes: alternative routes toward rechargeable batteries based on abundant elements

Storing large amounts of electrical energy is a major challenge for the forthcoming decades. Today, lithium-ion batteries (LIBs) are considered the best option for electric vehicles and grid storage but these rising markets put severe pressure on resource and supply chains. The principle of LIBs is based on solid electrodes separated by a liquid electrolyte between which Li ions are reversibly exchanged during charge and discharge. The efficient Li+ transport in the different phases and across the interfaces is essential for achieving a good performance. A fundamental difference between ion transport in solid phases and ion transport in solutions is that the ions are “naked” in the solid phase but solvated in the liquid phase. Recently major efforts have been initiated to adopt the successful LIB concept to other working ions such as Na+, K+, Mg2+, Ca2+ or Al3+. This is motivated by the promise of lower cost thanks to their abundance as well as in some cases higher energy density. The progress, however, is limited mainly due to an unfavourable mismatch between the solid electrode host structures and the ion radii or too large charge/radius ratios. Especially multivalent ions lead to severe lattice polarization frustrating ion mobility in solid electrodes.
This project aims at a radically different concept, i.e. instead of “naked” ions, solvated ions will be intercalated into the electrodes. Solvent co-intercalation is traditionally considered as highly detrimental. Latest results, however, question the generality of this argument. The SEED project will explore the concept of using solvated ions in solid electrodes for the reversible storage of a variety of ions. As the solvation shell acts as electrostatic shield and can be tuned in its composition, lattice polarization can be minimized. Using this effect, the SEED project finally aims at enabling reversible charge storage of multivalent ions in host structures with properties far beyond current state-of-the art.
Nuclear Power Generation

In this chapter nuclear power generation systems are introduced. In the first part of the chapter the basic theory of nuclear reaction is reviewed as a prerequisite for understanding nuclear fuels and controlled generation of nuclear heat. Conventional and advanced concepts for nuclear fuel are then studied. All types of conventional reactors for nuclear power stations and advanced generation reactors are introduced. As cogeneration represents a major development trend for nuclear power generators, a section of this chapter is dedicated to cogeneration schemes of power and district heating, power and high-temperature process heat, power and desalination, and power and hydrogen generation. The chapter includes several illustrative examples and case studies.
Consolidation and commercial bank net interest margins: Evidence from the old and new European Union members and candidate countries

Abstract This paper examines the effects of financial reforms on the determinants of commercial bank net interest margin in the banking systems of the new EU member countries and candidate countries by dividing the sample period (1995–2006) into two sub-periods: consolidation period (1995–2000) and post-consolidation period (2001–2006). The paper also compares the new and old EU members to check whether differences with respect to the determinants of net interest margins between these two groups of countries exist within the same time period. The results indicate that size and managerial efficiency are negatively and significantly related to net interest margins in the two sub-periods. Regulators should promote merger and acquisition and market entry in order to increase the scale and efficiency of banks operating in the sector. Exploitation of the scale economies seems to be important in decreasing the interest rate spread in the sampled banking sectors. The results further indicate that all macroeconomic variables are statistically insignificant in the second sub-period, suggesting that differences in macroeconomic fundamentals have decreased among the sampled countries due to the increased convergence process in recent years. As for the comparison of the new and old EU members, the results suggest that the financial and economic convergence between the new and old members has not been completed. Macroeconomic differences within the group and between the groups still exist.
Recognition of a new nothrotheriid genus (Mammalia, Folivora) from the early late Miocene of Achiri (Bolivia) and the taxonomic status of the genus <i>Xyophorus</i>

des établissements d'enseignement et de recherche français ou étrangers, des laboratoires publics ou privés.
Method and system for selectively retrieving text strings

A method (50) and system(10) for selectively retrieving text strings from a plurality of stored text strings contained on a data storage medium accessible by a processor (12) can include a data input device (18) providing a query to the processor. The processor can be programmed to receive (52) the query, determine a number of significant words in the query (54), determine a number of significant words in a candidate text string (56), determine a number of matches between the significant words in the query and the candidate text string (58), and compute a match score (60) for each candidate text string using the number of significant words in the query, the number of significant words in the candidate text string, and the number of matches. The system can further include a speaker (21) or a display device (22) rendering (68 or 69) at least one candidate text string having the largest match score.
Development and testing under real-world conditions of the Attitude Determination and Control System (ADCS) for observation microsatellites.

The project concerns the development and verification under real-world conditions of an Attitude Determination and Control System (ADCS) dedicated to observation microsatellites, in particular microsatellites equipped with SAR radar. The most important project results address key areas related to the effective use of microsatellites, i.e. (a) The ability to determine in real time the precise position of the satellite in orbit (below 1 m) and its orientation in space. It is important to ensure a good geolocation of the purpose of SAR imaging, as well as to address the problem of the imprecision of relative positioning (motion error). b) Possibility of time synchronisation of the transmitter and receiver of cooperative satellites for consistent signal processing and range measurement — a key property in the context of the operation of microsatellites in formation. Article: 25 of Commission Regulation (EU) No 651/2014 of 17 June 2014 declaring certain categories of aid compatible with the internal market in the application of Articles 107 and 108 of the Treaty Urz.
Demystifying the quark-gluon plasma

The primary objective of this project is to explore the properties of a new state of matter, the Quark-Gluon Plasma (QGP), at the highest energies to date. The QGP consists of asymptotically free quarks and gluons and the evidence for its discovery was announced in experiments analyzing collisions of heavy ions. Previous experiments at lower energies have caused a dramatic change of paradigm in our understanding - measurements at Relativistic Heavy Ion Collider showed that the QGP behaves like a strongly coupled liquid, instead of the weakly interacting gas expected by theorists. The focus of this project is the measurement of the anisotropic flow, which has proven to be the most informative probe for studying the properties of nuclear matter produced in heavy-ion collisions. The analysis methods to be utilized are multiparticle correlation techniques developed by the PI. Currently mainly the first moments (averages) of multiparticle correlations are used. Within the scope of the theoretical subproject we aim to derive analytic expressions for higher order moments of multiparticle correlations by continuing a pioneering work recently initiated by the PI. The here proposed project aims also the measurement of new flow observables, so-called Symmetric Cumulants, recently introduced in the field by PI. The recent restart of Large Hadron Collider at top energy, a record breaking 5.02 TeV center of mass energy, offers a truly unique and a timely opportunity for this project. The main dataset will comprise the heavy-ion collisions collected with ALICE detector at the Large Hadron Collider. Collisions of smaller systems will be scrutinized as well in order to determine the onset of QGP formation. This project offers a unique opportunity to pin down quantitatively the properties of the QGP, beyond the rather qualitative analyses that are currently carried out in the field. It also will impact the fields of high energy physics, nuclear physics, cosmology and hydrodynamics.
Targis - variable rate smart fertilizing system in precision agriculture

Precision agriculture is a practice that adopts high information technologies like GPS, control units and software for the purpose of optimizing yield according to local varying soil conditions while conducting agricultural inputs applications (planting, fertilizing, spraying and harvesting, land surveying, line handling systems, yield mapping and grain loss monitoring systems). Current precision agriculture technology platforms provide compact system solutions. Traditionally manufactured agriculture machines, commonly used in European countries cannot adapt precision agriculture technologies. Precision agriculture platforms in Europe are mainly based on ISO-bus structures that are compatible only with ISO-bus tractors, which
are advanced and highly expensive solutions. However, the current structure of TARGIS-VRA can be adapted to traditional agricultural machines and attains 25% to 30% fertilizer conservation (due to 5 years of field studies). As a result, precision farming is made possible for traditionally manufactured machines and pays itself of in maximum one year for a single farmer with 20 hectares of average field size.
Innovative low-mass tanks for a low-cost, low-carbon european micro-launch vehicle

Small satellites (smallsats) are playing an increasingly significant role in space. Smallsats currently fly to space via ridesharing – taking spare capacity on a large launcher. Rideshare has numerous issues, including lack of availability, severe launch delays, and unsuitable orbits. Orbex is developing an EU-based orbital micro-launch vehicle with a uniquely innovative advantage that eliminates the issues of rideshare and mitigates the cost of a dedicated launch for smallsat operators. The vehicle exploits the properties of dual-cryogenic propellants to create an innovative, lightweight, low-cost tanking
arrangement that reduces the inert mass of the launch vehicle by as much at 30% over traditional designs, and enable the world’s first environmentally-friendly rocket fuel strategy, with a 90% reduction in environmental impact. The small satellite launch market is well established and growing rapidly. The market for smallsat launch services is projected to grow US$2.52B p.a, by 2022, a CAGR 23.2%. The benefits of developing this tanking system for a European micro-launch vehicle include:- 
• Lowering cost of space access, including logistics/integration
• Reduced delay in time-to-market
• Enabling faster revenue generation for smallsat business models
Orbex staff have designed & realized a prototype tank, and subsequently drafted patents for the technology. The tank was instrumented, hydrostatically pressure-tested and then used to prove the concept in cryogenic conditions. The objective of this SME Instrument Phase 2 project is to build on a prior SME Instrument Phase 1 feasibility study of the materials, suppliers and production processes required to implement this novel fuel tank concept using European materials and techniques at full scale. This Phase 2 project allow a European company to compete for this large, global market with significant, sustainable cost and operational advantages over global competitors.
"Shadow of Abandonment": Graham Greene's <i>The Confidential Agent</i>

�� ��� When compared with what usually are considered Graham Greene’s “major” novels, The Confidential Agent (1939) may seem oddly marginal. 1 Unlike such better-known narratives as The Power and the Glory (1940), The Heart of the Matter (1948), The Quiet American (1954), A Burnt-Out Case (1961), and The Honorary Consul (1973), Greene’s ninth production does not explore in depth any of his characteristic themes—the theological mystery of grace, the ambiguity of love versus pity, the entanglements of postcolonial intervention, the recuperation of existential purpose, and the moral dilemma of responsibility for others. To this can be added the fact that its author categorized The Confidential Agent as an “entertainment,” a designation that pigeonholed it along with Stamboul Train (1932), A Gun for Sale (1936), The Ministry of Fear (1943), and Our Man in Havana (1958) as a type of fiction that gave priority to the development of plot rather than character. Further qualifying the text’s standing within Greene’s corpus are the circumstances of its composition. As recounted by biographer Norman Sherry, in 1938 Greene methodically cranked out 2,000 words per day in the mornings for six weeks, all the while fueling his creative effort with Benzedrine, before laboring more deliberately on The Power and the Glory—at his customary stint of five hundred words—during the afternoons (2: 14). Given these factors it perhaps is unsurprising that Greene’s story about “D.,” a former lecturer in medieval French literature who endeavors unsuccessfully to negotiate a coal contract in Great Britain on behalf of his unnamed socialist country (Republican Spain), is not as widely read as his “mature” work. If we recontextualize The Confidential Agent, however, its stature grows. As John Coates has demonstrated, Greene’s novel rigorously challenges the “pre-1939 thriller” popularized by Erskine Childers, John Buchan, Dornford Yates, William Le Queux, E. Phillips Oppenheim, and “Sapper” or H. C. McNeile (48). Central to these earlier “Clubland” adventure sagas during the years prior to World War I was a xenophobic “them”/“us” binary that vilified the former while valorizing the latter
Technological consortium to develop sustainability of underwater cultural heritage

Documentation and conservation of Underwater Cultural Heritage (UCH) is crucial to preserve humankind’s history and traditions, safeguarding tangible testimonies of past human life while ensuring its accessibility to present and future generations. TECTONIC project will promote an intersectoral collaboration between academic and non-academic professionals (such as technical experts, archaeologists, conservator, geologists, engineers, computer scientists) working in different topics related to the UCHs to respond and find solutions to the complex issues still existing in the field of UCH. The overall aim is the exchange of skills and expertise, the training activities for the implementation, improvement and assessment of innovative materials, techniques, tools and methodologies to develop solutions and marketable products for the conservation, restoration and management of the UCH (objects, artefacts, structures, remains etc.). To achieve its overall aim, TECTONIC project will undertake innovation and development activities driven by the following objectives:  Study, documentation and 3D reconstruction of the selected pilot sites;  Decision support tool for UCH risk assessment in a changing environment;  Conservation studies, protocols and suitable procedures for preservation/conservation activities;  Development of open and low-cost robotic solutions for the inspection, documentation and monitoring of UCH;  Raising the public awareness and knowledge about the importance to preserve the underwater historical and archaeological heritage.  All the objectives will be devoted to stimulate new ideas that would bring to the development of new marketable products by capitalizing on the research results that will be achieved in the project, creating a link between business, research and higher education.
Two-way network for distributing catv signals to premises by means of optical fibers

A telecommunications network makes use of optical fibres for carrying the amplitude modulated broadband CATV signal to the subscriber's premises and for carrying a signal of the DOCSIS type from the subscriber's premises to the head end. A dual broadband optoelectronic repeater regenerates the signal arriving from the head end and retransmits it along a plurality of fibres in parallel which transmit it to the subscriber's premises. The same repeater regenerates the optical signal arriving from the individual subscribers and retransmits it optically or electrically to the head end. A programmable microprocessor is used for the remote connection and disconnection of the individual subscribers to and from the broadband repeater.
Development of the internationalisation of Render Art Małgorzata See through the increase in export of services offered as a result of the implementation of the industry promotion program Construction and Exclusion of Construction.

Reference number of the aid programme: SA.42799(2015/X) Purpose of public aid:_Art.19 SA 42799(2015/X) Render Art Małgorzata Widaj provides services in the form of architectural visualisations. Through modeling, rendering and post-production, high-quality artistic visualisations are created, which illustrate architectural and urban designs. Visualisations concern architectural objects at the design and design stage (those that have not yet been created). They aim to combine digital design with expressions of artistic expression in order to reflect as much as possible the intentions of their designers. The markets covered by the project: a) USA (Prospective Market), UAE (Prospective Market) – entry into two new markets (b) Germany, the Netherlands, the United Kingdom – export development in three markets Promotion Programme: II. Construction and Exclusion of Buildings. Planned participation in trade fair events: — EXPO REAL, Munich, Germany, 7-9 October 2019 – BUILDING HOLLAND, Amsterdam, Netherlands, 9-11 April 2020 – Ecobuild, London, United Kingdom, 5-7 March 2020 – New York Build EXPO, New York, USA, 12-13 March 2020 – AIA Conference on Architecture, Las Vegas, USA 14-16.05.2020 – Big5, Dubai, United Arab Emirates, 25-28 November 2020 AIA Conference on Architecture, Las Vegas, USA 14-16.05.2020 – Big5, Dubai Organisation, United Arab Emirates, 25-28 November 2020 AIA Conference on Architecture, Las Vegas, USA 14-16.05.2020 – Big5, Dubai, United Arab Emirates organisation, 25-28 November 2020 The project is also planned for the acquisition of services to the market in the market. The away missions will concern the fairs: — Imm Cologne, Cologne, Germany, 13-19.01 2020 – Nahb IBS, USA, Las Vegas, 20-23.01.2020 – Provada, Amsterdam, The Netherlands, 04-06.06.2020 The main objective of the project is to increase the internationalisation of Render Art Małgorzata Widaj through the implementation of an industry promotion program for the Construction and Financing of Buildings in the field of internationalisation of the company. The project will contribute to the objectives of PO IR 2014-2020 and to the action of the GO TO BRAND programme itself. Project