SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Benralizumab en asma grave eosinófilica a un año de tratamiento. SEDENA

Introducción: el asma eosinofílica es el fenotipo más común del asma grave.Benralizumab recientemente fue aprobado para su uso en México en agosto de 2019 como tratamiento complementario para asma grave no controlada con fenotipo eosinofilico en pacientes adultos.Objetivo: el objetivo de este estudio es describir la eficacia y seguridad de benralizumab a 12 meses en pacientes con asma grave eosinofilica
Predicting the restricted mean event time with the subject's baseline covariates in survival analysis

For designing, monitoring, and analyzing a longitudinal study with an event time as the outcome variable, the restricted mean event time (RMET) is an easily interpretable, clinically meaningful summary of the survival function in the presence of censoring. The RMET is the average of all potential event times measured up to a time point τ and can be estimated consistently by the area under the Kaplan-Meier curve over $[0, \tau ]$. In this paper, we study a class of regression models, which directly relates the RMET to its "baseline" covariates for predicting the future subjects' RMETs. Since the standard Cox and the accelerated failure time models can also be used for estimating such RMETs, we utilize a cross-validation procedure to select the "best" among all the working models considered in the model building and evaluation process. Lastly, we draw inferences for the predicted RMETs to assess the performance of the final selected model using an independent data set or a "hold-out" sample from the original data set. All the proposals are illustrated with the data from the an HIV clinical trial conducted by the AIDS Clinical Trials Group and the primary biliary cirrhosis study conducted by the Mayo Clinic.
Divide the dollar and conquer more: sequential bargaining and risk aversion

We analyze the problem of dividing a fixed amount of a single commodity between two players on the basis of the Nash bargaining solution (NBS). For one-shot negotiations, a cornerstone result of Roth (Axiomatic models of bargaining. Springer, Berlin, 1979) establishes that the more risk averse player will obtain less than half the total amount. In the present paper, we assume that the bargaining procedure occurs over several rounds. In each round, an increasing share of the total amount is negotiated over in accordance with the NBS, the disagreement point being determined by the outcome of the previous round. In line with Roth’s result, the final amount received by the more risk averse player is still bounded by half the total amount. As a new feature, however, this player does not lose from bargaining for more rounds if his opponent exhibits non-increasing absolute risk aversion. What is more, both players’ risk profiles become essentially irrelevant if successive bargaining takes place over sufficiently small commodity increments. Each player then gets approximately half of the commodity.
Feasibility of fiber optic displacement sensor scanning system for imaging of dental cavity

The purpose of this study is to investigate the potential of intensity modulated fiber optic displacement sensor scanning system for the imaging of dental cavity. Here, we discuss our preliminary results in the imaging of cavities on various teeth surfaces, as well as measurement of the diameter of the cavities which are represented by drilled holes on the teeth surfaces. Based on the analysis of displacement measurement, the sensitivities and linear range for the molar, canine, hybrid composite resin, and acrylic surfaces are obtained at 0.09667 mV/mm and 0.45 mm; 0.775 mV/mm and 0.4 mm; 0.5109 mV/mm and 0.5 mm; and 0.25 mV/mm and 0.5 mm, respectively, with a good linearity of more than 99%. The results also show a clear distinction between the cavity and surrounding tooth region. The stability, simplicity of design, and low cost of fabrication make it suitable for restorative dentistry.
A hybrid genetic algorithm for automatic graph drawing based on the topology-shape-metric approach.

This paper presents a new approach for automatic graph drawing based on Genetic algorithms. The classical topology-shape-metric approach for orthogonal graph drawing keeps a fixed planar embedding obtained in its first step (planarization), using it for the next two steps (orthogonalization and compaction). However, each step is itself an NP-hard problem, and the choices made and heuristics used on previous stages have a direct impact on subsequent ones.We can, alternatively, obtain a large number of planar embeddings by varying the order of insertion of the graph's edges when constructing such embeddings. Following that, the genetic algorithm is applied to select the planar embeddings that would lead to the final best drawing, after evaluating its performance on the subsequent orthogonalization and compaction steps. We formulate the problem of finding an optimal planar embedding for the graph as a permutation-based combinatorial optimization problem. The problem is then solved with the genetic algorithm, using appropriate selection, crossover and mutation operators, which were adapted from other permutation-based optimization problems, such as scheduling problems.The results show that our approach is able to find better solutions, representing improved final graph drawings than the ones found via the classical topology-shape-metric approach.
Retailer’s optimal replenishment policy in a two-echelon supply chain under two-part delay in payments and disruption in delivery

Now-a-days, the risks associated with transportation have received special attention among the global traders due to the unusual circumstances such as terrorist attack, earth quake, mishandling in transport, shipping damage, misplacing products etc. A mathematical model for an inventory system under such transport risk conditions is highly useful to run the supply chain (SC) smoothly and it paves the way to minimize the total cost incurred. In business, many suppliers offer two-part delay in payments, say \( (\alpha /M_{1} ,{\text{ net }}M_{2} ) \), in order to attract their retailers. This paper investigates retailer’s inventory system in a SC under the random effect of risk in delivery from a supplier to the retailer. Here, the supplier offers two-part trade credit to his retailer and the retailer in turn offers a full credit period to the customers. The total cost incurred at the retailer’s inventory system is minimized and the optimal replenishment policies are determined. Mathematical theorems are developed and numerical examples are presented to illustrate the sensitivity analysis of inventory key parameters.
Managing the Industrial Territories in the Knowledge Era

Business Areas and Industrial Parks (BAIPs) are important policy and planning instrument for local and regional development. Well planned and equipped BAIPs stimulate the relocation of industries and help to relieve congestion and pollution in metropolitan areas. The successful development of a region depends fundamentally on the region's capacity to support and sustain the competitiveness of its local firms by creating a rich milieu of synergies between agencies, firms and the science- technology base. Innovative firms succeed at the micro level by ensuring that they have the capacity to organise resources to match the evolving challenges of their markets. Successfully run and developed BAIPs will continue to play the major role in regional and local economies, but managers must find new  ways to support and revitalise BAIPs as spaces that can support innovation, dynamic growth and higher added value in SMEs. MITKE focuses on providing a platform and mechanisms for collection,
exchange and transfer of experiences and views among the partner regions in order to find and test better solutions and tools for intervention and thus contribute to an improved management of Business Areas and Industrial Parks (BAIPs) accross Europe.  MITKE therefore is in line with the INTERREG IVC programme, which focuses on interregional cooperation, and pursues to improve the effectiveness of regional development policies. Furthermore, the key areas identified by the INTERREG IVC programme, innovation, knowledge economy, the environment and risk prevention, are in line withe the key challenges faced by the BAIPs and the SMEs, and will be addressed by the project.  A set of instruments are planned to enable exchange of experiences among regions such as interregional workshops and study visits, practitioners forum on the website, sharing of good practices. Furthermore, the transfer of good practices and the definition of Improvement Plans for specific BAIPs are expected to
contribute to the improvement of regional policies and instruments in order to support BAIPs better face the challenges posed by the global economy. MITKE pays special attention to matching less experienced regions with the ones with more experience as it reflected in the consortium. Europe wide impact is expected through the events, web site and practitioners forum and support from international multiplying organisations such as EURADA is expected in this sense. The agreement of a Joined Action Plan with commitment to its deployment together with the practitioners forum and policy recommendations, are oriented to support the sustainability of the project and capitalisation of its results. The MITKE partnership is composed by 11 partners with several years of experience in managing BAIPs, being 6 of them regional development agencies, 4 Business networks and land developers and 1 research centre. The partnership is representing 10 regions spread over 7 different EU countries.
Mechanisms of neurotransmitter uptake and storage by synaptic vesicles

Summary
In presynaptic nerve endings, neurotransmitters are stored in synaptic vesicles (SVs) before they are released by exocytosis. SVs contain specific transporters that sequester and concentrate transmitters from cytoplasmic pools. All known vesicular transporters belong to the solute carrier (SLC) superfamily of proteins. They draw the energy for transport from an electrochemical proton gradient created by a V-ATPase across the vesicle membrane. However, despite recent progress it is still largely unclear how synaptic vesicles are filled with hundreds of mM transmitter within less than a minute. Open questions include (1) how exactly transport is linked to the proton gradient and which ions are coupled to solute transport, (2) how two different transmitters can be accommodated by the same SV, and (3) how much transmitter can be loaded into an SV and how the stored transmitter is kept inside and prevented from leaking out. 
Here we will focus on the vesicular transporters for glutamate (VGLUTs) and GABA/glycine (VGAT or VIAAT), the main excitatory and inhibitory transmitters in the CNS, and on the vesicular transporter for ATP (VNUT). Primarily we will use biochemical approaches employing purified SVs and artificial vesicles, recombinant proteins (either purified and reconstituted in liposomes or using vesicles isolated from transfected cells), in combination with quantitative in vitro assays, for characterizing the features of transport and storage. To achieve this, we plan to develop advanced methods involving adaptation of new fluorescent probes and microscopic analysis of loading and unloading using microfluidic devices. For these experiments, vesicles will be captured by affinity ligands such as antibodies printed on glass surfaces. This allows for analyzing small numbers of vesicles such as SVs derived from primary cultured neurons or transport vesicles from transfected cells that are tagged and labeled with fluorescent reporters before isolation.
METHOD AND DEVICE FOR PRODUCING AN MFC FILM

A method of casting an MFC film on a substrate (52) comprises providing an MFC dispersion having a solids content of 2,5-25 % by weight, and a viscosity above 4 Pas at a shear rate of 20 s-1; exposing the MFC dispersion to a first shearing step (9), providing a shear rate of above 10 s-1; introducing the MFC dispersion into a film forming device (4), laterally distributing (41) the MFC dispersion; exposing the distributed MFC dispersion to a second shearing step (42), providing a shear rate of above 100 s-1; decelerating (43) the distributed MFC dispersion; exposing the MFC dispersion to a third shearing step (44), providing a shear rate of above 100 s-1; and simultaneously with, or subsequent to, the third shearing step (44), depositing the MFC dispersion on the substrate to form a wet MFC film on the substrate.
Nb-Iot robust tracking  and monitoring solution

Solutions for asset tracking and monitoring are mainly powered by ordinary mobile data connectivity such as 2G and 3G with high subscription and maintenance costs every year. This lack of affordability significantly decreases the number and types of assets that businesses can pay for monitoring; which especially affects SMEs and verticals with a low profit margin like waste management or construction and demolition. Consequently, they suffer usually equipment theft, loss and poor asset management.
StalkIT makes asset tracking & monitoring affordable for SMEs and opens the market to new asset types, including much smaller, lower-value items. However, reliability is always a key issue for new technologies. For this reason, we have tailored our innovation for harsh environments as proof of concept for the application of our technology in other verticals. 
Based on the brand-new NB-IoT & LTE-M (LPWA) technologies, StalkIT is a full-stack solution formed by two ground-breaking pillars: 
-A robust tracking device 10 times less expensive than current offerings designed to support IoT connectivity on lower-powered mobile data networks. This allows a practically maintenance free since the battery lasts up to 10 years. Besides, it is tailored to harsh environments (Rated IP67). As such, it suits applications in the waste recycling sector. 
-A cloud platform which allow users have access to a monitoring software though mobile App and web portal. This includes a multi-layer map showing live and historic devices position, list of all devices sorted at customer’s preference, user administration and control and overview of all sensors.
On exploiting social relationship and personal background for content discovery in P2P networks

Content discovery is a critical issue in unstructured Peer-to-Peer (P2P) networks as nodes maintain only local network information. However, similarly without global information about human networks, one still can find specific persons via his/her friends by using social information. Therefore, in this paper, we investigate the problem of how social information (i.e., friends and background information) could benefit content discovery in P2P networks. We collect social information of 384,494 user profiles from Facebook, and build a social P2P network model based on the empirical analysis. In this model, we enrich nodes in P2P networks with social information and link nodes via their friendships. Each node extracts two types of social features-Knowledge and Similarity-and assigns more weight to the friends that have higher similarity and more knowledge. Furthermore, we present a novel content discovery algorithm which can explore the latent relationships among a node's friends. A node computes stable scores for all its friends regarding their weight and the latent relationships. It then selects the top friends with higher scores to query content. Extensive experiments validate performance of the proposed mechanism. In particular, for personal interests searching, the proposed mechanism can achieve 100% of Search Success Rate by selecting the top 20 friends within two-hop. It also achieves 6.5 Hits on average, which improves 8x the performance of the compared methods.
Rational development of bioprocess engineering strategies for recombinant protein production in Pichia pastoris (Komagataella phaffii) using the methanol-free GAP promoter. Where do we stand?

The increasing demand for recombinant proteins for a wide range of applications, from biopharmaceutical protein complexes to industrial enzymes, is leading to important growth in this market. Among the different efficient host organism alternatives commonly used for protein production, the yeast Pichia pastoris (Komagataella phaffii) is currently considered to be one of the most effective and versatile expression platforms. The promising features of this cell factory are giving rise to interesting studies covering the different aspects that contribute to improving the bioprocess efficiency, from strain engineering to bioprocess engineering. The numerous drawbacks of using methanol in industrial processes are driving interest towards methanol-free alternatives, among which the GAP promoter-based systems stand out. The aim of this work is to present the most promising innovative developments in operational strategies based on rational approaches through bioprocess engineering tools. This rational design should be based on physiological characterization of the producing strains under bioprocess conditions and its interrelation with specific rates. This review focuses on understanding the key factors that can enhance recombinant protein production in Pichia pastoris; they are the basis for a further discussion on future industrial applications with the aim of developing scalable alternative strategies that maximize yields and productivity.
Co-channel interference mitigation technique for mobile WiMAX downlink system deployed via Stratospheric Platform

This paper aim at evaluating an interference mitigation technique proposed for Stratospheric Platform (SPF) WiMAX downlink system. Performance evaluation of mobile WiMAX system under impact of co-channels interfering from the SPF antennas operating in the same frequency band is proposed to be studied in this paper. Several frequency reuse pattern are simulated to find the best reuse pattern which means that they have a minimum interference level. Simulation results clearly demonstrate that the co-channel interference was dominant when delivering mobile WiMAX via SPF and its performance can be effectively improved using frequency reuse patterns. Results relative to co-channel interfering evaluation, showed an improvement on the system performance with increasing frequency reuse pattern (from 1 to 3, or from 3 to 4). The remaining results with respect to BER simulation indicate how K Rice factor which is governed by elevation angle, Doppler shifts due to mobility, and physical layer setting of broadband system can contribute to the overall performance. Finally, simulation results clarified that applying spatial diversity at transmitter side can improve the performance at low elevation angles.
Building new models for the economic revitalization of central urban areas

Decline or loss of attractiveness of central urban areas is a common challenge of the 'Urbe Viva' partnership. Decline is related to a variety of economic and social factors, the most visible being an inflation of suburban shopping centres. To address this issue, it is necessary to adopt integrated approaches, as tested in countries such as the UK, Sweden, Belgium or France. Such approaches aim to harmonize structural, economic, environmental and cultural interventions into one coherent policy including customized solutions for town-center management of the affected areas and establish professional public/private bodies responsible for coordinating their implementation. The Urbe Viva network aims to increase awareness of public authorities at local, regional and national level on possibilities to improve the effectiveness of economic urban development. More specifically, the operation aims at developing a method to analyze urban areas, evaluate their strengths and weaknesses, and identify appropriate measures to counteractthe decline of central urban areas and create steady public/private partnerships and forms of “negotiated” and “participated” town planning. The operation raises awareness and knowledge about effective strategies and tools for urban development, in particular as regards town-center management and methodologies for ex-ante and ex-post evaluation of urban development instruments and policies. It supports the creation of public/private partnerships and forms of “negotiated” and “participated” town planning in the participating urban areas. Activities include analyzing partners' experiences and collecting international best practices, developing joint methods for analyzing partner areas and elaborating operative tailor-made models of coordinated urban management.
Magnetic alignment for high precision 3d assembly

In microelectronics, 3D integration and assembly definitely appears as a very efficient option to achieve highly integrated chips. It offers major benefits such as combining heterogeneous technologies, combining high-performance and low-power chips,  increasing data transfer bandwidth in memory above logic circuits, etc. 3D assembly is realized by bonding two wafers or chips face to face on a wafer. In this bonding process, the number of interchips interconnects is limited by the accuracy of the alignment process. Presently, alignment methods rely on optical alignment techniques which offer ±0.2m resolution for wafer-to-wafer bonding or only ±1m resolution for die-to-wafer bonding. This is relatively poor and limit the density of interconnects and therefore the bandwidth of interchip communication. In this ERC PoC project, we intend to establish the viability of a novel magnetic alignment approach based on nanomagnetism and spin electronics which could yield unprecedented accuracy in alignment during wafer bonding. 
The goals of MAGALIGN are i) to make a proof of concept of this novel alignment method, ii) optimize it and develop the design tools to exploit it, iii) Develop industrialization strategy.
PLASMA DISPLAY

The invention concerns alternating voltage plasma displays which, with the development of high-definition television, are becoming increasingly important. With such displays, it is already possible very satisfactorily to produce screens of optimal flatness and size. However, a drawback of known plasma displays is the fact that problems of brightness and luminosity arise at the required high definition. In the plasma display according to the invention, this problem is solved by an electrode structure which ensures significantly larger gas discharge regions by comparison with known electrode structures.
COLD GAS GENERATOR

A cold gas generator for inflating a gas bag with the aid of a gas flowing from a gas pressure container (7). The gas pressure container (7) is provided with an outlet (1) which is sealed by a destructible membrane (2) which is domed in the opposite direction in relation to the stored gas. The membrane (2) is destroyed by means of a jet of hot gas which is directed onto the membrane (2) and which is exclusively produced by igniting an ignition pellet (4) which can be activated by applying an electrical pulse. In order to provide a cold gas generator whose structure includes a simple operating mechanism, offering a high degree of security for the passengers and which inflates the gas bag without destroying or damaging it, when the gas pressure container (7) is in a filled state, the surface (6a) of the membrane (2) opposite said container is fully directed in an open manner towards an area (12) which is connected to the gas bag via at least one outlet (11), through which area the jet of hot gas focussing on the membrane (2) from a nozzle chamber can be guided (5).