SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Gut-Brain-Axis: targets for improvement of cognition in the elderly

In Europe, the population is aging. The age-associated decline in cognitive functions represents a serious social and medical
problem. Recent studies show that changes in lifestyle such as physical activity and nutritional interventions – even late in
life –are beneficial for cognition. The microbiome in the gut is a central effector in the maintenance of brain plasticity and
therefore represents a promising target as well as sensor for interventions that aim to improve cognitive ability in the elderly.
Detailed and concise scientific investigations of gut-brain interactions, in particular in the elderly, are limited. Such studies
require a multidisciplinary approach and a combination of experts from various fields. The aim of our network is to train a
new generation of young scientists within a multidisciplinary consortium. The ESRs will engage in individual and well
defined, jointly supervised research projects, securing excellent career perspectives and employability. By enabling ESRs to
design and conduct studies in this economically and socially important field, SmartAge will elucidate the role of the
microbiome-gut-brain axis in aging and its impact on cognition. SmartAge will apply a translational approach combining
animal and human studies, nutritional and life style interventions, cognitive tests, brain imaging, cutting edge OMICS and
systems biology as well as fecal transfer as proof of principle to identify key regulators of gut-brain communication with the
aim to develop microbiome-based therapies. An expert team of scientists from both academia and industry such as clinicians, psychologists, nutritionists, biotechnologists and bioinformaticians will closely collaborate to strengthen
microbiome research in aging which will have a direct impact on cognitive health in Europe. Specialists for public
communication outreach will ensure effective and efficient transfer of outcomes to policy makers and into the everyday life of
the European population.
Nuclear transport facilitated by the interaction between nuclear pores and carbohydrates

The nuclear pores located on the nuclear envelope work as a selective barrier to nuclear import. The transport of large cargo molecules (larger than ∼40 kD) into the nucleus generally requires the aid of nuclear transport proteins, such as importins, which bind to nuclear localization signal (NLS) sequences in the cargo molecules and transport these molecules into the nucleus through the nuclear pore. In our previous paper, we showed that maltotriose(Glc3)-displaying quantum dots (QDs) can pass through the nuclear pore in digitonin-treated HeLa cells. The aim of this study is to clarify the mechanism of the nuclear import of maltooligosaccharide-displaying QDs (maltooligo-QDs). We prepared maltopentaose(Glc5) and maltoheptaose(Glc7)-QDs in addition to Glc3-QDs. The effect of the number of glucose units in the maltooligosaccharide on the rate of nuclear import of QDs has been explored by confocal laser scanning microscopy (CLSM). Further, we analyzed that the direct interactions of maltooligo-QDs to an internal protein in the nuclear pore (Nucleoporin62) using a surface plasmon resonance (SPR) system. We found that maltooligo-QDs with more than three glucose units (Glc3, Glc5 and Glc7-QDs) rapidly entered the cellular nucleus, and had a higher affinity to nucleoporin62 than those of PEG and Glc1-QDs. These data indicate that the interaction between nuclear pores and carbohydrates is the driving force behind the nuclear import of maltooligo-QDs.
DR LUIGI RUBY

FREELANCER AND UNIVERSITY PROFESSOR IN SEVERAL ITALIAN UNIVERSITY IN DIGITAL DENTISTRY, COMPUTER-ASSISTED SURGERY, ODONTOIATRICAE RADIOLOGY AND HISTORY OF MEDICINE. SPEAKER AT INTERNATIONAL CONGRESSES. INVENTOR VRUBINO, VIRTUAL REALITY APPLIED IN DENTISTRY, IN MEDICAL AND BEYOND. I AM A SPECIALIST SURGEON IN ODONTOSTOMATOLOGY. OWNER OF THE SINGLE-PROFESSIONAL DENTAL PRACTICE IN GENOA; PILOT CENTER/STUDY OF TECHNOLOGICALLY ADVANCED DENTAL/MEDICAL COMPANIES. EMPLOYEES 1/2 ASSISTANTS TO THE CHAIR; I WORK WITH 1 DENTAL HYGIENIST AND WITH SEVERAL ITALIAN DENTAL LABORATORIES
Soil carbon, nitrogen and phosphorus ecological stoichiometry of<i>Phragmites australis</i>wetlands in different reaches in Minjiang River estuary

Ecological stoichiometry is the study of the balance of energy and multiple chemical elements.Generally,this perspective examines the causes and consequences of elemental imbalances between resources,producers,and consumers in the environment.C,N and P are key elements controlling organism growth.However,the relative needs of the elements are poorly quantified,and dependencies between elements are not well investigated.These three elements are strongly coupled in their biochemical functioning.Furthermore,the ecological stoichiometry of C,N and P is the indication for organic carbon decomposition and nutrition limit. The element ratios in wetlands,especially for the estuarine wetlands,appear to be more variable than other ecosystems worldwide.Moreover,the studies on soil C,N and P stoichiometry have not been thoroughly studied.In fact,soil as the carrier of organisms and elements plays very important roles.Therefore,studies on C,N and P ecological stoichiometry of wetland soils will be favorable to clarify the available of nutrition and the cycle and balance of C,N and P. An amount of approximately 18,000 km of coastline in China is covered by an estimated 12,000 km2 of tidal estuary wetlands.These tidal wetlands are generally rich in animal and plant biodiversity and appear to have important biogeochemical roles within the entire estuary ecosystem.One of these important tidal wetland ecosystems is found within the Minjiang River estuary in southeast China,which is located at the transition of mid-and southern subtropical climate zones in China. Phragmites australis is the dominant species in Minjiang River estuarine wetland and distributes everywhere from upper reach to lower river.Here we chose the Youxizhou wetland,Bianfuzhou wetland and Shanyutan wetland as the study areas and examined the ecological stoichiometric characteristics of wetland soils in different river reaches and their indication.In upper reach,the values of soil C/N,C/P,N/P(0—60 cm) of P.australis wetland were 36.5—51.3,43.0—93.6 and 0.8—2.3,with averages of 44.1,66.9 and 1.6,respectively.In middle reach,the values of soil C/N,C/P,N/P(0—60 cm) were 15.8—21.7,28.0—72.2 and 1.6—4.2,with averages of 17.6,45.7 and 2.6,respectively.In lower reach,the values of soil C/N,C/P,N/P(0—60 cm) were 13.5—19.8,63.6—125.4 and 4.2—6.3,with averages of 16.4,90.5 and 5.5,respectively.C/N,C/P and N/P ratios appeared various tendencies among wetlands in different reaches.Soil C/N ratios were in the order of upper reachmiddle reachlower reach,C/P ratios were in the order of lower river upper rivermiddle river,while N/P ratios were in the order of lower reachmiddle reachupper reach.The variation of C/N,C/P,N/P ratios in soil profile of single reach was smaller than that among different reaches.Soil water and silt contents were the key factors controlling the change of C/N,C/P,N/P ratios of wetland soils in different reaches.Soil C/N and N/P ratios were preferable indication for anaerobic carbon decomposition.
LOI SUR LE CRÉDIT D’IMPÔT NO 208/2015 S.M.I. 3R S.R.L.

LE PROJET D’INVESTISSEMENT PRÉVOIT L’AGRANDISSEMENT DE LA STRUCTURE EXISTANTE PAR LA MODERNISATION DES INSTALLATIONS, DES MACHINES ET DES ÉQUIPEMENTS EXISTANTS. EN PARTICULIER ÃŠPREVISTO L’INSTALLATION D’UN SYSTÈME DE CONDITIONNEMENT DU SIÈGE À TRAVERS L’INSTALLATION DICHILLER AVEC POMPE À CHALEUR POUR LE CHAUFFAGE/REFROIDISSEMENT HYDRONIC, SYSTÈME ET DIVERSES VANNES, NONCHÃŠ L’INSTALLATION DE MACHINEVENTILANTI À ONDULEUR À VITESSE VARIABLE. ACQUISITION D’UN NOUVEAU PORTE-PALETTES MONOFRONT ET DOUBLE FACE, BALAYEUSES N°2 HOMMES À BORD MARCAIPC MODÈLE LION1250, N. 2 CHARIOTS ÉLÉVATEURS MARQUE OM ENCORE MOD.XD30PLUS, NO 1 MARQUE DE CHARIOT ÉLÉVATEUR BAOLI MOD.KBE30J, DISPOSITIF DE STOCKAGE ÉLECTRIQUE ATIMONE MARQUE BAOLI TIPOES15-N02
Accelerating market introduction of active noise cancelling headrest solutions

Worldwide, 1 bn people are at great risk of being hearing impaired. The increasing noise pollution in everyday life results in an unwanted
restriction of the quality of life. Noise is a stressor that affects our circulation largely unconsciously via the autonomic nervous system. In the
frequency range below 1 kHz, the demand for insulation materials is increasing strongly. Therefore, the lack of space for and increasing cost
of passive noise insulation is not an adequate solution in off-highway machines, commercial vehicles, trucks/cars, airplanes/public
transportation. Wearing headphones is not an option for comfort, safety and health reasons.

To counteract the stress and danger factors of noise, recalm is developing a health-promoting acoustic device that is integrated into seats.
By emitting an anti-sound signal, noise is canceled out by means of destructive interference. Unique features of the product can be stated as
follows: the device allows an active noise compensation (ANC) in the “far field” - without headphones. As a result, recalm is the first company to
offer active noise reduction in the far field in Off Highway Machines. Extensive research and initial discussions with potential customers and
cooperation partners from this industry underline the urgent need in the market.

In the long term, cars and commercial vehicles as well as public transport and airplanes are to be equipped. Here the worldwide market potential
amounts to EUR 312.4 billion per year. For the market entry, however, the focus is on the construction and agricultural machinery market in
Germany. Extensive research and initial discussions with potential customers and cooperation partners from this industry underline the urgent
need in the market. The annual market potential amounts to 1.7 billion EUR worldwide.

In order to accelerate the market entry, but also to identify additional features for the product, a beta test with drivers of construction machinery
should be carried out.
Single-Incision Sleeve Gastrectomy Using a Novel Technique for Liver Retraction

INTRODUCTION Laparoscopic sleeve gastrectomy has rapidly gained popularity in the field of bariatric surgery, mainly due to its low morbidity and mortality. Traditionally, 4 to 6 trocars are used. Single-access surgery has emerged as an attempt to decrease incisional morbidity and enhance cosmetic benefits. We present our initial 7 patients undergoing single-incision laparoscopic sleeve gastrectomy using a novel technique for liver retraction. METHODS Patients who underwent single-incision laparoscopic sleeve gastrectomy between March 2009 and May 2009 were analyzed. A 4-cm left paramedian incision was used. Laparoscopic sleeve gastrectomy was performed in a standard fashion using a 40 French bougie. RESULTS Seven patients underwent single-incision sleeve gastrectomy at the University of Illinois at Chicago. They were all female with a mean age of 34 years. Preoperative BMI was 49 kg/m² (range, 39 to 64). There were no intraoperative complications. Mean operative time was 103 minutes. Estimated blood loss was minimal. All 7 patients were discharged on postoperative day 2 and were doing well without any complications at 3.1 ± 0.7 months after surgery. CONCLUSION Single-incision laparoscopic sleeve gastrectomy is safe and feasible and can be performed without changing the existing principles of the procedure. Our technique for internal liver retraction provides adequate exposure and is reproducible. Development of improved standard instrumentation is required for this technique to become popular.
Evaluation of Total Brain Acetylcholine in rats treated with inhaled Tetrahydrocannabinol. (A Bioassay Study)

A Bioassay study using rabbit ileum was used to evaluate changes in Total Brain Acetylcholine of wistar rats treated for 4, 8 and 12 weeks with inhaled tetrahydrocanabinol smoke; a widely abused substance worldwide. Puffing of cannabis smoke was performed with the use of a Hamilton syringe delivering 100-ml puffs at 20-sec intervals into the nose -only manifold for a total of 5 minutes. Smoke was first pumped into a 500ml dilution chamber with the aid of a vacuum pump. The smoke was then displaced from the dilution chamber through the nose-only manifold at 300 ml/min; that is the rats received Inhaled THC at 5ml/sec for 5 minutes. After treatment the rat Brains were accessed for Total Brain Acetylcholine (TBA) levels. To achieve this; an increasing amounts of homogenized Brain extracts from the rats in each group and Laboratory acetylcholine were used and their ability to contract the rabbit ileum when introduced into an organ bath was recorded as height of contraction which was then used to calculate actual TBA concentration. This was first done for all groups to first determine an effective dose to be used. For the actual Bioassay study the chosen effective dose of 0.5ml of Brain preparation from Control group, 4, 8, 12 weeks treated groups and standard Laboratory Acetylcholine were used to determine the concentrations of Total Brain Acetylcholine present in the Brain extracts. Atropine was also introduced to ascertain the presence of Ach in the Brain extracts. The experiments showed significant increase in TBA in the treated rats showing an accumulation of Ach in the Brain due to THC inhalation. This is part of a series of studies to establish the influence of THC on the neurotransmitter acetylcholine and cells of the Brain stem for its possible importance in neurotransmitter deficiency and related neurodegenerative diseases. Keywords: Total Brain Acetylcholine (TBA), Tetrahydrocannabinol (THC), Inhalation treatment, Bioassay,  Rabbit ileum,  Height of Contraction, Nose-Only smoke model.
Maternal and perinatal risk factors for SIDS: a novel analysis utilizing pregnancy outcome data

A number of maternal and perinatal factors to increase an infant's risk of sudden infant death syndrome (SIDS) have been found in past investigations. We analysed data for potential SIDS risk factors including the presence of complications or conditions considered as detrimental to the infant's or mother's health. The data for 118 SIDS cases and 227 matched controls were obtained from a state pregnancy outcome unit. SIDS was found to be significantly more common in cases where the infant's mother was not in a relationship (i.e. divorced, separated or never married) (p = 0.005), if the infant was not the first born (p = 0.0001) and when the mother resided in a socioeconomically disadvantaged area (p = 0.03).Overall, this SIDS cohort appears to display classical SIDS associations, and our findings are consistent with those from other regions. This novel epidemiological tool opens the way for a national Australia-wide study using pregnancy outcome data collected by the individual states and could be helpful in assessing maternal and fetal risk factors for other paediatric medical conditions.
(16807.19102018.132000767) STUDIO E SVILUPPO DI MODELLI DI GIOIELLI

RAIKA SRL, AZIENDA OPERANTE NEL SETTORE ORAFO VUOLE AUMENTARE LA PROPRIA CAPACIT? DI PENETRAZIONE NEL MERCATO E DI RISPONDERE IN MODO PI? EFFICACE ED EFFICIENTE ALLE ESIGENZE DELLA CLIENTELA.IN PARTICOLARE RAIKA, SRL, VUOLE ACCRESCERE LA PROPRIA OFFERTA ALL?INTERNO DELLA LIBIA, MERCATO CHE NELL?ULTIMO DECENNIO HA RAPPRESENTATO UNO SOCCO IMPORTANTE PER IL DISTRETTO ORAFO ARETINO. PER QUESTO GRAZIE AI CONSULENTI PROGETTER? E REALIZZER? UNA SERIE DI NUOVI MODELLI E PROTOTIPI DI GIOIELLI, PENSATI PER ESSERE OTTENUTI TRAMITE PROCESSO DI ELETTROFORMATURA. SARANNO IDENTIFICATI E PROGETTATI GLI STRUMENTI RIVOLTI ALLA COMUNICAZIONE DELL?AZIENDA, AL FINE TRASFERIRE AL MERCATO L?IDEA E LO STILE CHE L?AZIENDA VUOLE PROPORREIL PROGETTO INTERVERR? ANCHE NEL PROCESSO DI DIGITALIZZAZIONE AZIENDALE GRAZIE ALLA MESSA A PUNTO DI STRUMENTI DI BI, CHE PERMETTANO DI FORNIRE SUPPORTO ALLA DECISIONI DEI RESPONSABILI DI PRODUZIONE, AL FINE DI MIGLIORARE LA PRODUZIONE SULLA BASE DELLE ESIGENZE DELLA CLIENTEL
Soil microbial community structure is unaltered by plant invasion, vegetation clipping, and nitrogen fertilization in experimental semi-arid grasslands

Global and regional environmental changes often co-occur, creating complex gradients of disturbance on the landscape. Soil microbial communities are an important component of ecosystem response to environmental change, yet little is known about how microbial structure and function respond to multiple disturbances, or whether multiple environmental changes lead to unanticipated interactive effects. Our study used experimental semi-arid grassland plots in a Mediterranean-climate to determine how soil microbial communities in a seasonally variable ecosystem respond to one, two, or three simultaneous environmental changes: exotic plant invasion, plant invasion + vegetation clipping (to simulate common management practices like mowing or livestock grazing), plant invasion + nitrogen (N) fertilization, and plant invasion + clipping + N fertilization. We examined microbial community structure 5-6 years after plot establishment via sequencing of >1 million 16S rRNA genes. Abiotic soil properties (soil moisture, temperature, pH, and inorganic N) and microbial functioning (nitrification and denitrification potentials) were also measured and showed treatment-induced shifts, including altered NO(-) 3 availability, temperature, and nitrification potential. Despite these changes, bacterial and archaeal communities showed little variation in composition and diversity across treatments. Even communities in plots exposed to three interacting environmental changes were similar to those in restored native grassland plots. Historical exposure to large seasonal and inter-annual variations in key soil properties, in addition to prior site cultivation, may select for a functionally plastic or largely dormant microbial community, resulting in a microbial community that is structurally robust to single and multiple environmental changes.
SYSTEM AND METHOD FOR DETECTION OF ZERO CURRENT CONDITION

The present invention is directed to a circuit that is configured to detect a zero current condition at a certain point. The circuit includes a current mirror coupled to two transistors, where the first transistor is coupled to ground and the second transistor is coupled to the point being sensed. The outputs of both the first transistor and the second transistor are each coupled to an input of a comparator. The comparator is configured to determine when an equal voltage condition is present at the two inputs, which signifies a zero-current condition. Such a zero current detector can be used in a buck regulator to prevent a current flow from load to ground and attendant inefficiencies that result. An alternative embodiment involves the use of a controller to sense three different voltages to determine the state of the switches.
Capturing Attention for Warnings about Insecure Password Fields – Systematic Development of a Passive Security Intervention

AbstractEavesdropping on passwords sent over insecure connections still poses a significant threat to Web users. Current measures to warn about insecure connections in browsers are often overlooked or ignored. In this paper, we systematically design more effective security interventions to indicate insecure connections in combination with password requests. We focus on catching the attention of the user with the proposed security interventions. We comparatively evaluate the three developed interventions using eye-tracking and report how effective these options are in the context of three different website designs. We find that one of the options – red background of the password field – captures significantly more attention than the others, but is less linked to the underlying problem than the yellow warning triangle option. Thus, we recommend a combination of the two options.Keywordssecurity warningssecurity interventionsmorphological approachattention
Trash-2-Cash: designed high-value products from zero-value waste textiles and fibres via design driven technologies

Within Trash-2-Cash, growing problems with paper fibre waste from the paper industry and textile fibre waste, originating from a continuously increasing textile consumption, will be solved through design-driven innovation. This will be performed by using the wastes to regenerate fibres that will be included into fashion, interior and other products. The cotton production suffers from non-sustainable environmental and socio-economical issues and the polyester fibre manufacture produces waste that to date has no viable deposition. Designers will lead the recycling initiative, defining the material properties, and will feed the material scientists to evaluate newly developed eco-efficient cotton fibre regeneration and polyester recycling  techniques. The future exploitation will be ascertained through a two-sided exchange between the designers and the end-product manufacturers, also taking into account the consumer-related product needs, and prototypes will be produced in a realistic test production environment.
The objectives are to:
• Integrate design, business and technology to a coherent discipline to establish new creative industries
• Develop new material and product opportunities via creative design from waste or process by-product
• Reduce the utilization of virgin materials; improve material efficiency; decrease landfill volumes and energy consumption
• Use design for recycling with the vision of closing the material loop
• Create new business opportunities by adding the return loop of the discarded goods to be reused into attractive products
• Promote development of the creative sector by providing technological solutions for exploitation of waste streams
Europe's creative industry will be strengthened through Trash-2-Cash taking the lead worldwide in the design for recycled materials area. Moreover, Trash-2-Cash will support a better waste utilization and contribute to reduction of landfill area needs.
Palliative Caregivers’ Spirituality, Views About Spiritual Care, and Associations With Spiritual Well-Being: A Mixed Methods Study

Spiritual care is integral to palliative care. It engenders a sense of purpose, meaning, and connectedness to the sacred or important and may support caregiver well-being.To examine caregivers' spirituality, religiosity, spiritual well-being, and views on spiritual/religious support.A mixed-methods study across 4 Australian sites, recruiting caregivers of patients with a life expectancy of under 12 months. The anonymous semistructured questionnaire used included research team developed and adapted questions examining religion/spirituality's role and support and views on hospitals supporting spiritual/religious requirements. It additionally included the Functional Assessment of Chronic Illness Therapy-Spiritual Well-Being Scale (FACIT-Sp-12).One hundred nine caregivers participated (47.4% responded). Median spiritual well-being was 30.5 on FACIT-Sp-12. Religious affiliation was associated with higher Faith subscores (P < .001). Spirituality was very important to 24.5%, religiosity to 28.2%, and unimportant to 31.4% and 35.9%, respectively. Caregivers prayed (P = .005) and meditated (P = .006) more following patients' diagnoses, gaining comfort, guidance, and strength. Caregivers whose spiritual/religious needs were met to moderate/full extent by external religious/faith communities (23.8%) reported greater spiritual well-being (P < .001). Hospitals supported moderate/full caregiver spiritual needs in 19.3%. Pastoral care visits comforted 84.4% of those who received them (n = 32) but elicited discomfort in 15.6%. Caregivers also emphasized the importance of humane staff and organizational tone in supporting spiritual care.Hospital-based spiritual care providers should seek to identify those who seek pastoral or religiously orientated care. Genuine hospitality of showing concern for the other ensures the varied yet inevitably humanist requirements of the caregiver community are met.