SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Development of kinetoplastida flap endonuclease inhibitors in search for novel therapeutics

We are searching for Kinetoplastida flap endonuclease (FEN) inhibitors as a base for potential therapeutics for parasite infections, for which there is significant unmet clinical need. Kinetoplastida are flagellated protists responsible for 3 neglected human diseases. We will target the FEN enzymes from Trypanasoma cruzi and Leishmania species, the organisms causing Chagas disease and leishmaniaisis respectively. FEN  activity is crucial for the survival of all organisms tested so far from mouse to bacteria, including Trypanosoma. We will identify specific inhibitors of Kinetoplastida FENs as the basis for future development of urgently needed new therapeutics. This multidisciplinary structure-based inhibitor design project will involve in vitro and in silico screening, protein crystallization, rounds of inhibitor design and finally in vivo potency and toxicity experiments. 
The project will be overseen by Prof Sayers who has 30 years of experience with nucleases and who has founded two spin-out companies. His group is complemented through collaboration with a parasitologist Dr Helen Price (20 years research experience), who has been actively involved in developing antiparasitic agents. The experienced researcher, who has a strong protein biochemistry and crystallography background, is returning to academic research after almost 4 years outside science. Ultimately, the experienced researcher is aspiring to an academic career in translational medicine rooted in state-of-the-art basic research but with the skills and experience to synergise with the pharmaceutical sector.
Parametric Analysis for Ultimate Strength Prediction of Stainless Steel Bolted Joints with Single Bolt

A variety of parametric studies utilizing the finite element analysis (FEA) have been performed by Kim et al in order to predict the mechanical behavior(ultimate strength) of single shear bolted joints in cold-formed(thin-walled) stainless steel. The precedent researches have been conducted with respect to the mechanical behaviors of single shear bolted joints fabricated with four bolts and two bolts. Subsequently, this study has been focused on the comparison of ultimate behaviors between the existing test results and FEA results. In addition, parametric study has been performed in order to investigate the influence of mesh size and washer existence on ultimate behaviors. Therefore, reasonable finite element modelling method and condition were recommended in this paper.
Notch2 regulates the development of marginal zone B cells through Fos

B cells are classified into several subsets depending on their functions, marker expression pattern and localization. Marginal zone B (MZB) cells are a distinct lineage from follicular B cells, and regulate host defenses against blood-borne pathogens. Notch2/RBP-J signaling regulates the development of MZB cells by interacting with delta-like 1 ligand, although the target genes for Notch2 signaling remain unclear. We identified Fos as an upregulated gene in LPS-stimulated B cells that received Notch2 signaling. Fos is expressed in CD21(high)CD23(low) MZB cells at a higher level compared to CD21(Int)CD23(high) follicular B cells. Deleting the Notch2 gene in CD19(+) B cells decreased Fos expression in B cells. Overexpression of Fos in Notch2-deficient B cells or bone marrow cells partially restored MZB development. Fos promoter activity was upregulated by Notch2 signaling, indicating that Notch2 directly controls Fos transcription associated with MZB development. These data identify Fos as one of the target genes for Notch2 signaling that is crucial for MZB development.
Developing fan engagement for increasing participation, attendance and commercial value in women's football

European women’s football has come a long way in recent years, yet it is still considerably underdeveloped. Football being one of the most revered forms of popular culture in Europe offers a unique window into evolution of roles and representation of achievements of women, but despite significant strides in recent years the women’s game is still far behind. Fewer sponsorship deals, lower stadium attendance and commercial value were a few of the problems with which women’s football struggled, even before the Covid-19 outbreak. Now, the sustainable survival of the game is under threat. In both industry and academia there is a gap in attention to women’s football fandom, particularly from the organisations’ side, and its potentials for commercial value creation and financial sustainability of the game. Taking the high potential of fandom  to generate sustainable income, the present project aims to develop fan engagement practice to increase attendance and commercial value in women’s football. I will employ a novel interdisciplinary, comparative participatory approach involving academia and industry stakeholders, identifying the unique attributes and current state of women’s football fandom and key components of an effective fan engagement framework for teams and associations. The project will be conducted in the context of Ireland and will be hosted by Dublin City University. To learn about fan engaging planning, practices and data analysis in the industry, I will carry out two secondments in two well-known sport marketing companies in Europe. Collectively, the outcomes of this project will provide a novel understanding of gendered perceptions of women’s football in Ireland and Europe, and how fan engagement can be tailored to women’s football for better commercialisation. The findings would help the industry engage fans effectively for the survival of the game, and future research can build up on the ideas and findings in different countries and women’s sports.
The micro-bio process: a comprehensive platform to capture co2 from indoor air, transform it into valuable carbon-neutral commodity chemicals

Indoor air quality (IAQ) is an important public health concern since most people spend 80-90 % of their time indoors. The coronavirus pandemic has increased the public awareness of the effects of poor IAQ. In enclosed indoor spaces fresh air supply can be very low or null and CO2 levels can reach health-threatening levels. Therefore, there is an increasing need to develop technologies to mitigate atmospheric CO2 and improve IAQ, but also technologies capable of transforming it into value-added products such as carbon-neutral commodity chemicals. The MICRO-BIO process is proposed as a comprehensive platform to capture CO2 from indoor air, transform it into valuable carbon-neutral commodity chemicals by developing a multi-unit, modular, and scalable platform process. The MICRO-BIO process is composed by three different modules: 1st a CO2 micro-concentrator module (CO2-MCM) to efficiently adsorb CO2 from indoor air. 2nd, the Microbial Electrochemical Synthesis Module where the H2 bioelectrochemically produced is mixed with CO2 from the CO2-MCM to produce short chain commodity chemicals. And 3rd, the Microbioreactor Module where the carbon-chain elongation process is performed in a capillary microbioreactor to produce hexanol, a sustainable liquid biofuel with high market demand. Objectives of the proposal: 1) Design and operation of a CO2-MCM prototype to efficiently adsorb CO2 from indoor air. 2) Development of a real-control system for steering gas bio-electro-fermentation towards selective production of hexanol. 3) Set-up a MICRO-BIO process prototype to demonstrate the optimized operation for hexanol production. This fellowship will contribute to addressing the actions included in the Green deal roadmap of the EU, by investing in environmentally friendly technologies and decarbonizing the energy section. Also shares the target of UN Sustainable Development goal titled ""Affordable and clean energy”: to facilitate access to clean energy research and technology.
Models, experiments and high performance computing for turbine mechanical integrity and structural dynamics in europe

Energy and Mobility are two primary driving forces in the 21st century. Development of incremental and disruptive technologies will have key impacts on the world’s societies, and on safety, security and competitiveness of Europe. Amongst those technologies, gas turbines will play a major role. Recovery of shale gas depends decisively on compressors. Modern gas supplied power plants are bridging towards the age of renewable energies. Aeroengines are to undergo the most massive changes in their history with the advent of composite materials, gear boxes, and turbine-electric concepts separating generation of power and thrust. A technological commonalities of the upcoming challenges is the need for full model based development and computer system simulation.

There is agreement on this in the computational fluid dynamics (CFD) community. The structural dynamics and vibration questions are at present far from being addressed adequately. While US agencies and Asian powers have already started to prepare themselves, European research organisations and companies still seem to be too fragmented to reach critical research ressources and start corresponding initiatives. There are two main reasons for this. First, the physics of mechanical joining technologies that dominate the damping behavior of the large-scale structures under debate, are still poorly understood. Second, there is a lack of high performance computing (HPC) capabilities in structural dynamics, which goes back to the lack of knowledge of effective HPC technologies for structural dynamics. 

Since the US, China and India have started efforts in the field, we propose a European contribution through a Marie Curie ETN to allow a first generation of early stage researchers to catch up on the topics, ideally open up new fields of insight and approaches, and finally form a seed group for the upcoming challenges of the European turbine industry with respect to nonlinear structural dynamics and HPC.
The value of testicular ‘mapping’ in men with non-obstructive azoospermia

As the field of assisted reproduction has advanced, many previously untreatable men are now biological fathers. Although finding sperm in men with obstructive azoospermia is not difficult, locating and retrieving spermatozoa in men with non-obstructive azoospermia remains a clinical challenge, largely because sperm production in these men can be patchy or focal in nature. In response to this challenge, strategies such as fine-needle aspiration (FNA) mapping have been developed to find spermatozoa. This review discusses the history, evolution and current clinical utility and findings with FNA mapping for male infertility). Review of the current literature in the English language on FNA (diagnostic or therapeutic) with a keyword focuses on sperm detection, retrieval, safety and complications. FNA was described in human medicine over 100 years ago. Testis FNA was described 45 years ago and FNA 'mapping' of spermatozoa was described in 1997. This comparative review of the literature on sperm detection and complication rates with FNA and open testis biopsy or microdissection procedures suggests that FNA is highly informative, minimally invasive and is associated with fewer complications than other commonly used approaches to sperm detection in non-obstructive azoospermic patients. FNA mapping has gained considerable traction as an informative, 'testis sparing' technique for sperm detection in non-obstructive azoospermia. With knowledge of sperm presence and location prior to sperm retrieval, FNA maps can help clinicians tailor sperm retrieval to optimize time, effort and extent of procedures needed to procure spermatozoa in these difficult cases.
Climate Change Adaptation by Spatial Planning in the Alpine Space

Climate change impacts, esp. growing risks from natural hazards, increasingly threaten settlements, infrastructure, lives and future development in the Alpine Space. CLISP aims at preventing increasing climate change-related spatial conflicts, vulnerability, damages and costs by providing "climate proof" spatial planning solutions as a substantial basis for future sustainable territorial development in the Alps. As climate change adaptation&mitigation is a novel field for spatial planning policy and administration, CLISP is a strategic pilot project. Its main pillars are assessment of the vulnerability of Alpine regions/municipalities to climate-change related risks, evaluation of the "climate change fitness" of current spatial planning systems and intense risk communication & governance in model regions. finally building the basis for the elaboration of "climate proof" spatial planning strategies for the Alpine Space & the Alpine countries and providing practical support for sustainable development decisions on reg./local level.
Unravelling the physics of particle acceleration and feedback in galaxy clusters and the cosmic web

We will unravel the origin of cosmic magnetic fields, the physics of particle acceleration in dilute plasmas, and the nature of AGN feedback with state-of-the-art radio telescopes. With the enormous gains in sensitivity, survey speed, and resolution of these telescopes – combined with recent breakthroughs that correct for phased-arrays and the Earth’s distorting ionosphere – we can now take the next big step in this field.

Cosmic web filaments and galaxy clusters are the Universe’s largest structures. Clusters grow by a sequence of mergers, generating shock waves and turbulence which heat the cluster plasma. In merging clusters, cosmic rays are accelerated to extreme energies, producing Mpc-size diffuse synchrotron emitting sources. However, these acceleration processes are still poorly understood. Clusters are also heated by AGN feedback from radio galaxies, but the total energy input by feedback and its evolution over cosmic time are unknown. We will construct the largest low-frequency sample of galaxy clusters to (1) establish how particles are accelerated in cluster plasmas, (2) quantify how the cosmic ray content scales with cluster mass, (3) determine the importance of AGN fossil plasma in the acceleration processes, (4) characterize current and past episodes of AGN feedback, and (5) determine the evolution of feedback up to the epoch of cluster formation (z=1-2). These results will be essential to understand cluster formation and its associated energy budget.

As in clusters, cosmic web accretion shocks should also accelerate particles producing radio emission. Based on the deepest low-frequency images ever produced, we will (5) carry out the first studies of these giant accelerators, opening up a new window on the elusive warm-hot intergalactic medium, where many of the cosmic baryons reside. Even more important, (6) we aim to obtain measurements of the intergalactic magnetic field, providing key constraints on the origin of our Universe’s magnetic fields.
The context and potential sustainability of traditional terrestrial periodic tambu areas: insights from Manus Island, Papua New Guinea

Within the Pacific over the last two decades there has been greater recognition of the pre-existing tools within indigenous communities for natural resource management. Periodic tambu (Tok Pisin: a prohibition) is an indigenous resource management tool often used across Papua New Guinea. On Manus Island terrestrial periodic tambu areas are characterised by a cycle of resource closure followed by instantaneous harvest. We examine the differing application of periodic tambu areas by three different clans who are using the technique to restock areas with the Admiralty cuscus (Phalangeridae: Spilocuscus kraemeri), an arboreal possum-like marsupial. We examined the plausibility of cuscus population recovery over differing closure periods at three different harvest rates using a composite female-only population projection matrix approach based on the vital rates of closely related phalangerid surrogates. The resultant trajectories suggest that commonly used closure durations may allow recovery at low to medium harvest rates (10–30%) but not at high harvest rates (50%). From this we infer that periodic tambu areas may be a sustainable strategy for customary resource use of Admiralty cuscus at low to medium harvest rates. We found periodic tambu management on Manus Island to be culturally dynamic with clans differing with respect to their purpose, adherence to tradition, and hybridisation with modern land governance practices. Given the past difficulties of imposing exogenous conservation systems in Papua New Guinea, we advocate greater exploration of the merits of endogenous systems such as periodic tambu areas.
Visual interference disrupts visual knowledge

Abstract We show that visual interference impairs people’s ability to make use of visual knowledge. These results provide strong evidence that making use of stored visual knowledge—long-term memory of what things look like—depends on perceptual mechanisms. In the first set of studies, we show that presenting visual noise patterns during or after hearing a verbal cue greatly reduces the effectiveness of the cue on a simple visual discrimination task. In the second experiment, participants were tasked with answering questions about visual features of familiar objects, e.g., verifying that tables have flat surfaces. Accuracy in answering visual, but not encyclopedic questions was reduced when viewing colorful noise patterns. This result is most parsimoniously explained by positing that judgments required activation of visual representations that were being interfered with when viewing irrelevant patterns. Although much of our conceptual knowledge may abstract away from perceptual details, knowledge of what things look like appears to be represented in a visual format.
Structural interdependence within top management teams: A key moderator of upper echelons predictions

Studies of the effects of top management team (TMT) composition on organizational outcomes have yielded mixed and confusing results. A possible breakthrough resides in the reality that TMTs vary in how they are fundamentally structured. Some are structured such that members operate independently of each other, while others are set up such that roles are highly interdependent. We examine the potential for three facets of structural interdependence—horizontal, vertical, and reward interdependence—to resolve ambiguities regarding effects of TMT heterogeneity. Based on a sample of TMTs in technology firms, we find that the three facets of structural interdependence are potent moderators of two classic predictions: the positive association between TMT heterogeneity and member departures, and between TMT heterogeneity and firm performance. Copyright © 2014 John Wiley & Sons, Ltd.
Including aviation in the European emissions trading scheme: Impacts on the industry, CO2 emissions and macroeconomic activity in the EU

In July 2008, motivated by the expected high growth of aviation and the related impacts on climate change, the European Parliament adopted a directive to include airlines in the European Emissions Trading Scheme. This paper discusses possible impacts of this inclusion on the aviation industry in terms of CO2 emissions and the macroeconomic activity in the EU. The analysis uses the Energy–Environment–Economy Model for Europe, a dynamic simulation model to investigate impacts of the European Emissions Trading Scheme on air transport. The impacts on air transport output and the macroeconomic effects are estimated to be small. This was robust to varying the carbon price. However, air transport CO2 emissions were expected to decrease by up to 7.4%, which is more than that estimated previously and stems mainly from the supply-side reaction of the industry.
“The Poet of Science”: How Scientists Read Their Tennyson

Alfred Tennyson’s attitude to science has been a perennial crit ical theme. s cholars have debated its overall tenor as well as his responses to particular theories, but two fundamental proposi tions have held sway. The first is that Tennyson eagerly followed scien tific developments, reading widely and carefully in several different sciences, including geology, astronomy, and biology, and building up a detailed knowledge of contemporary science in the process. The second is that his response to science as a whole was ambivalent. A. C. Bradley set the terms of the debate in a 1914 lecture, “The r eaction against Tennyson.” For Bradley, Tennyson was “the only one of our great poets whose attitude towards the sciences of Nature was what a modern poet’s ought to be . . . the only one to whose habitual way of seeing, imagining, or thinking, it makes any real difference that Laplace, or for that matter Copernicus, ever lived” (31). At the same time, the nature revealed by science, with its “conflict, pain, and waste” (10), posed a “problem” (11) for Tennyson that William Wordsworth, with his unscientific view of nature’s benevolence, did not have to face. Tennyson’s critics have been tasked with determining the nature and extent of this problem and Tennyson’s response to it. At best, in Henry sidgwick’s words, he was acutely conscious of science’s “inade quacy to satisfy our deepest needs” (qtd. in H. Tennyson 1: 303); at worst,
Field line helicity and solar eruptivity

The research project ‘fiEld Line helIcity and Solar eruptivITY’ (ELISITY) will examine the reasons behind the eruptive behaviour of the Sun, and the possibility of forecasting it. The importance of the project stems from the relation of solar eruptivity to Space Weather, and the international effort put in predicting the latter. ELISITY will study the behaviour of the minimally-explored physical quantity field line helicity (FLH) during the production and early stages of solar eruptions. FLH is a proxy for the density of helicity that offers new and important capabilities in the study of solar eruptivity, since it contains the same information with magnetic helicity, the conserved in ideal magneto-hydrodynamics quantity that describes the complexity of a magnetic field, and in addition, it provides information for the locations where helicity is more important. ELISITY will also determine parameters related to the spatial distribution of FLH that indicate eruptivity, and conditions on these parameters for solar eruptions to occur. For these, ELISITY will select observational cases which exhibit different levels of activity and morphology, using existing data from solar missions. The project will accurately compute FLH based on the researcher’s recent developments on the topic. The host institute will provide all required infrastructure and services to assist the researcher, and the supervision by very experienced staff. The project will have a positive impact to all parts involved: the researcher will gain new research skills in using solar observations, and also teaching experience, while the research team of the host will gain on state-of-the-art helicity and FLH computation methods. The potentially ground breaking project results will be disseminated with the publication of scientific articles to peer-reviewed journals, and their presentation to scientific conferences; they will also be communicated to the general public with outreach activities.