SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
European experts consensus: BRCA/homologous recombination deficiency testing in first-line ovarian cancer

Homologous recombination repair (HRR) enables fault-free repair of double-stranded DNA breaks. HRR deficiency is predicted to occur in around half of high-grade serous ovarian carcinomas. Ovarian cancers harbouring HRR deficiency typically exhibit sensitivity to poly-ADP ribose polymerase inhibitors (PARPi). Current guidelines recommend a range of approaches for genetic testing to identify predictors of sensitivity to PARPi in ovarian cancer and to identify genetic predisposition.To establish a European-wide consensus for genetic testing (including the genetic care pathway), decision making and clinical management of patients with recently diagnosed advanced ovarian cancer, and the validity of biomarkers to predict the effectiveness of PARPi in the first-line setting. The collaborative European experts' consensus group consisted of a steering committee (n = 14) and contributors (n = 84). A (modified) Delphi process was used to establish consensus statements based on a systematic literature search, conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-analyses guidelines.A consensus was reached on 34 statements amongst 98 caregivers (including oncologists, pathologists, clinical geneticists, genetic researchers, and patient advocates). The statements concentrated on (i) the value of testing for BRCA1/2 mutations and HRR deficiency testing, including when and whom to test; (ii) the importance of developing new and better HRR deficiency tests; (iii) the importance of germline non-BRCA HRR and mismatch repair gene mutations for predicting familial risk, but not for predicting sensitivity to PARPi, in the first-line setting; (iv) who should be able to inform patients about genetic testing, and what training and education should these caregivers receive.These consensus recommendations, from a multidisciplinary panel of experts from across Europe, provide clear guidance on the use of BRCA and HRR deficiency testing for recently diagnosed patients with advanced ovarian cancer.
Mental health commissioning: master or subject of change?

Purpose – The purpose of this paper is to explore change within the commissioning of third sector mental health services in England. Design/methodology/approach – A case study methodology based on survey and interview data of a sample of third sector organisations and commissioners within an English conurbation. Findings – Normative commissioning models based on sequential cycles were not fully implemented with the main focus being on the procurement and contracting elements. There were examples of commissioning being an enabler of service improvement but overall it seems to have been limited in its ability to bring about whole system change. Barriers included commissioners’ capacity and competence, ineffectual systems within their organisations, and fragmentation in commissioning processes between user groups, organisations and sectors. Research limitations/implications – The case study conurbation may not represent practice in all urban areas of England and there may be particular issues of difference within rural localities. The view of private and public sector providers and those working in Commissioning Support Units were not sought. Practical implications – To lead whole system change the commissioning function needs to be adequately resourced and skilled with better integration across public sector functions and organisations. Greater emphasis needs to be placed on implementing the full commissioning cycle, including the engagement of relevant stakeholders throughout the process and the practical application of outcomes. Originality/value – This research adds to the limited body of empirical work regarding commissioning in mental health.
La pandemia diabete in Italia

Sommario In Italia vivono circa 4 milioni di persone con il diabete e ogni anno ci sono circa 350 mila nuove diagnosi. Le persone con diabete ricevono prescrizioni di farmaci, esami di laboratorio e strumentali e richiedono ricoveri ospedalieri più spesso delle persone senza il diabete. Il diabete è gravato da aumentata mortalità e accorcia la vita, soprattutto nelle persone di media età. La qualità della cura nelle persone con diabete è subottimale, soprattutto fra chi non è assistito nei centri diabetologici (che, peraltro, rappresentano dei luoghi “salvavita”). Il diabete contribuisce fortemente alla spesa sanitaria e comporta ingenti spese, non tutte specificamente sanitarie. Nonostante tutto questo e nonostante leggi nazionali e regionali, documenti di indirizzo nazionali e regionali, PDTA regionali e locali, promesse e proponimenti di varia provenienza, la pandemia diabete non riceve le attenzioni che merita.
Revisiting Ghana’s 2008 Presidential Run-Off Election

Election is the major means through which representatives are chosen by the electorate. It is, therefore, the medium by which there can be a peaceful transfer of power from one government to another. Several elections have been held in Ghana since 1946. The thrust of this paper however, is to critically review the 2008 Presidential run-off between Nana Akuffo-Addo of the then ruling National Patriotic Party (NPP) and Prof John Evans Atta mills of the National Democratic Congress (NDC) and its implications for democratic consolidation in Ghana. Relying solely on secondary sources for data the paper reveals that the discovery of oil and the denial of the NDC of power for nearly a decade heightened the tension between the two parties especially in the two run-offs.
METHODS AND SYSTEMS FOR FORMING A COMPOSITE YARN

A method and system for forming composite yarns having selected performance characteristics including cut resistance and/or fire/heat resistance. The composite yarn will include a core of one or more filaments and a fiber bundle wrapped about the core and integrated with one or more additional filaments that help bind the fibers about the core. An additional filament or other composite yarn can be plied together therewith to form the finished composite yarn. The core filament(s) will be selected from cut and/or fire/heat resistant materials, while the fibers of the fiber bundle and the additional filament(s) wrapped about the core can be selected from natural or synthetic fibers or filaments having additional desired properties.
Whole Wheat Storage Warehouses in the Quenched and Tempered Ventilation Integrated Application Technology Research

The use of aerodynamic principles,the principle of ultra-high pressure,will be subject to force access to clean water jet technology with a single fluid atomization devices,water pumps in high-pressure atomization and accelerate the expansion cavity and vents,three front-end to complete fog after,the enter air relative humidity 85%~95%,with up to take 7.5 kW.h type centrifugal fan,ventilation methods uplink cycle,30 days to 50 # large warehouse(60 m × 27 m × 6 m) grain thickness 5.7 m,an average of 11.0% water,the number of rotation to be the 7 343 t Hard White Wheat database,the average increased to 11.91% moisture,moisture evenly,and changing food situation changes in the normal,the input and output ratio 1∶3,to create better results.
Peering Beyond the Imperial Gaze: Using Digital Tools to Construct a Spatial History of Conquest

Ethnohistorians and other scholars have long noted how European colonial texts often concealed the presence and participation of indigenous peoples in New World conquests. This scholarship has examined how European sources (both texts and maps) have denied indigenous history, omitted indigenous presence, elided indigenous agency, and ignored indigenous spaces all while exaggerating their own power and importance. These works provide examples of colonial authors performing these erasures, often as a means to dispossess. What they lack, however, is a systematic means of identifying, locating, and measuring these silences in space and time. This article proposes a spatial history methodology which can make visible, as well as measurable and quantifiable the ways in which indigenous people and spaces have been erased by colonial narratives. It presents two methods for doing this. First, narrative analysis and geovisualization are used to deconstruct the imperial histories found in colonial European sources. Second it combines text with maps to tell a new (spatial) narrative of conquest. This new narrative reconstructs indigenous activity through a variety of digital maps, including ‘mood maps’, indigenous activity maps, and maps of indigenous aid. The resulting spatial narrative shows the Spanish conquest of Peru was never inevitable and was dependent on the constant aid of immense numbers of indigenous people.
DISPENSING DEVICE FOR BOTH FROTH AND NON-FROTH COATINGS

A dispensing device (10) capable of dispensing both frothed and non- frothed liquids, the dispensing device having in order a fluid transport medium (20) defining a flow channel (25), a trigger controlled liquid flow regulator (30) defining a flow channel (35) through which fluid may flow when the trigger (37) is in one position but not when the trigger is in another position, a flow block (50) defining a flow channel (55) in fluid communication with a gas channel (65) and removably attached to the flow regulator, a flow restriction orifice (40) between the flow block and the flow regulator (30), a mixing block (70) defining a flow channel (75) containing mixing elements and optionally stabilization (80) and extension blocks each containing a flow channel (85) wherein each flow channel is in fluid communication with one another.
Global higher integrability of minimizers of variational problems with mixed boundary conditions

We consider integral functionals with densities of p -growth, with respect to gradients, on a Lipschitz domain with mixed boundary conditions. The aim of this paper is to prove that, under uniform estimates within certain classes of p -growth and coercivity assumptions on the density, the minimizers are of higher integrability order, meaning that they belong to the space of first order Sobolev functions with an integrability of order p + ϵ for a uniform ϵ > 0 . The results are applied to a model describing damage evolution in a nonlinear elastic body and to a model for shape memory alloys.
Characterization of nutrient removal and microalgal biomass production on an industrial waste-stream by application of the deceleration-stat technique

Industrial wastewaters can serve as a nutrient and water source for microalgal production. In this study the effluent of an internal circulation (IC) reactor anaerobically treating the wastes of a biotechnology production facility were chosen as the cultivation medium for Chlorella sorokiniana in batch and continuous cultures. The aim was to evaluate the rates of nutrient removal and biomass production possible at various dilution rates. The results demonstrate that the industrial wastewater served as a highly effective microalgae culture medium and that dilution rate strongly influenced algae productivity in a short light-path photobioreactor. Batch culture on undiluted wastewater showed biomass productivity of 1.33 g L(-1)day(-1), while removing over 99% of the ammonia and phosphate from the wastewater. Deceleration-stat (D-stat) experiments performed at high and low intensities of 2100 and 200 (μmol photon m(2)s(-1)) established the optimal dilution rates to reach volumetric productivity of 5.87 and 1.67 g L(-1)day(-1) respectively. The corresponding removal rates of nitrogen were 238 and 93 mg L(-1)day(-1) and 40 and 19 mg L(-1)day(-1) for phosphorous. The yield on photons at low light intensity was as high as had been observed in any previous report indicating that the waste stream allowed the algae to grow at its full potential.
Research and Implementation of DNS-White-List Tool Based on C#.NET

This paper provides a viable solution to tackle Kanminsky's DNS cache poisoning attack. By analyzing DNS's resolution methods and the principle of the cache poisoning attack, the concept of cache file and hosts file is introduced in this paper. The purpose of using hosts file is to reduce the impact of DNS cache poisoning attack. By using a DNS-white-list tool based on C#.NET, the mapping of domain names and IP addresses can be added or modified in hosts file. Comparing with the existing solutions, randomize port ID and DDSSEC, this paper starts from the cache file. The DNS-white-list tool can reduce harm of DNS cache poisoning attack effectively and protect the client.
Understanding information for legal protection of people against information-induced harms

Information can harm people. Think of being denied mortgage or insurance based on your grocery shopping or online surfing profile. But what exactly is it in information that is harmful, and how can people be protected? The current legal answer is that protection (data protection principles, rights and obligations) is granted when a) there is information b) about or potentially affecting a person c) who is identified or identifiable. This is Personally Identifiable Information (PII). But now that virtually all information is PII, how can law meaningfully protect against information-induced harms?
Given modern data collection and processing techniques and unprecedented amounts of data available for analysis, everything can be translated into data and anyone can be identifiable in data sets. Therefore, PII-based legal protection will fail, since a law regulating everything is meaningless. 
Yet, alternatives for structuring legal protection other than through the concept of PII are lacking. INFO-LEG innovates by looking for substitutes for the notion of PII to fundamentally re-organise legal protection. Promising new organising notions will be found through better understanding of information, how it links to people and harms. The approach is unique in integrating how law, economics, and information studies conceptualise information. INFO-LEG will theoretically and empirically explore external and internal conceptual boundaries of information and produce a multidisciplinary taxonomy of information. The notions from this taxonomy will be assessed on their suitability to substitute PII as new organising notions for legal protection against information-induced harms.
The multidisciplinary conceptualisation of information will impact scholarships studying how other areas of law regulate information in digital age: intellectual property (drawing borders of rights in information objects); constitutional law (if data is protected speech); telecommunication and cybercrime.
Service design for innovation

Service Design for Innovation (SDIN)-ETN aims to integrate service design and service innovation approaches that are now dispersed into an innovative research training framework; doing so leverages the creative power of service design to foster innovation. Specific objectives are: creating a mass of researchers who can drive widespread application of service design to leapfrog innovation in European organisations; and developing interdisciplinary competences in the key SDIN area and in key service sectors -ICT, public services and utilities. 
SDIN training programme comprises: individual research projects with interdisciplinary supervision (design and management) and non-academic involvement; substantial non-academic training (through hosts and secondments); development of competences in at least one key service sector, with exposure to other sectors; and network wide training with innovative courses, workshops, transferable skills training, and network wide training events. 
A strong consortium with unique combination of expertise will implement SDIN. Academic beneficiaries provide a rich training experience and research competences in service design and service innovation. The three non-academic beneficiaries are innovation leaders in ICT, public services and utilities, providing a rich ground for application of SDIN results to multiple sectors. 
SDIN will have significant impacts on ESRs, partners, and the pursuit of the Innovation Union: SDIN will develop interdisciplinary and multi sectorial competences in ESRs, which are highly valued and have a strong innovation impact on organisations. Beneficiaries will integrate their expertise to build enduring interdisciplinary and multi-sector competences in SDIN. SDIN’s extensive dissemination will ensure that the results achieved are shared with wider communities, thus producing spill over effects to other sectors. SDIN can make a significant and timely contribution to the Innovation Union strategy.
A standard bacterial isolate set for research on contemporary dairy spoilage

Food spoilage is an ongoing issue that could be dealt with more efficiently if some standardization and unification was introduced in this field of research. For example, research and development efforts to understand and reduce food spoilage can greatly be enhanced through availability and use of standardized isolate sets. To address this critical issue, we have assembled a standard isolate set of dairy spoilers and other selected nonpathogenic organisms frequently associated with dairy products. This publicly available bacterial set consists of (1) 35 gram-positive isolates including 9 Bacillus and 15 Paenibacillus isolates and (2) 16 gram-negative isolates including 4 Pseudomonas and 8 coliform isolates. The set includes isolates obtained from samples of pasteurized milk (n=43), pasteurized chocolate milk (n=1), raw milk (n=1), cheese (n=2), as well as isolates obtained from samples obtained from dairy-powder production (n=4). Analysis of growth characteristics in skim milk broth identified 16 gram-positive and 13 gram-negative isolates as psychrotolerant. Additional phenotypic characterization of isolates included testing for activity of β-galactosidase and lipolytic and proteolytic enzymes. All groups of isolates included in the isolate set exhibited diversity in growth and enzyme activity. Source data for all isolates in this isolate set are publicly available in the FoodMicrobeTracker database (http://www.foodmicrobetracker.com), which allows for continuous updating of information and advancement of knowledge on dairy-spoilage representatives included in this isolate set. This isolate set along with publicly available isolate data provide a unique resource that will help advance knowledge of dairy-spoilage organisms as well as aid industry in development and validation of new control strategies.
Unlock the full power of your point of sales

The Luntarium new web and mobile application simplify work for sales reps, stockers and merchandisers selling consumer goods into retail stores and supermarkets while giving full visibility to managers at head office. The software is an innovative and disruptive web platform and mobile technology solution targeted to mass consumer products companies in the EU. The application has high powerful tools in a simple user interface that allow companies monitor prices, out of stock, product availability, product range control, geotagged photos of store fronts, shelves or promotional materials and more for brands and its competition in real time. It has integrated collaboration features like messages, announcements and client notes are a great tool for team management while all reps activities are Geo tagged and monitor. With the tool teams can perform surveys, audits and order management activities. The prototype software was built with Wisis Rapid Ajax Application Framework developed by our key partner Infologic S.A., leading edge technology for extreme fast customized software development at the highest level of client expectations using the latest Java / J2EE and Ajax technology environment. The need of this unique software was discover while working closely with Group Danone, multinational market leader of daily and mass market products. Danone needed to boost sales at the point of sales, and responds to its competitors and leverage their customers’ with new ways of shopping by mobilizing their customer experience, it’s partner’s stores, and it’s entire value chain. The client could not find any software available on the market. The software prototype has been already implemented successfully in 2014 at Danone Argentina with excelent feedback from 50 fields’reps. We need to complete our feasibility study to introduce this unique software in the EU. Luntarium development and marketing teams will further developed the feseability report and business plan.
MOTOR CONTROL CIRCUIT FOR A BRUSHLESS WASHING MACHINE MOTOR

The invention relates to a motor control circuit (10) for a brushless washing machine motor (12), comprising an inverter stage (14) for controlling the power of the brushless motor and comprising a control stage (16) for generating control signals for the inverter stage (14). The inverter stage is controlled by the control stage via control lines (46a, 46b, 46c, 48a, 48b, 48c). A protective circuit (50) is provided for switching off the control lines. The invention further relates to a washing machine comprising such a motor control.
Shaping democratic spaces: security and tv series

In France, the UK, Germany, the US, and Israel, a growing number of films and television series are set ‘behind the scenes’ of democratic regimes faced with terrorist threats. These works reveal a moral state of the world. They may be analysed as ‘mirrors’ of society, or as ideological tools. But they can also be understood as new resources for the education, creativity, and perfectibility of their audiences; as the emergence of a form of ‘soft power’ that can serve as a resource for public policies and democratic conversation.
Because of their format (weekly/seasonal regularity, home viewing) and the participatory qualities of the Internet (tweeting, sharing, liking, chat forums), series allow for a new form of education by expressing complex issues through narrative and characters.
As a result, TV series are increasingly recognised in current research. However, their aesthetic potential for visualising ethical issues and their capacity at enabling a democratic empowerment of viewers has not yet been analysed ; nor their power for confronting cultural and social upheavals underway, and developing a collective inquiry into democratic values and human security.
DEMOSERIES brings together a team of scholars of moral philosophy, film studies, digital media and cultural data, sociology, law and political science, to explore a corpus of TV ‘security series’ from conception to reception. Doing so requires a particularist ethics based on attention to multi-faceted situations, paired with qualitative methods (interviews with security experts, showrunners, viewers; analyses of images, tropes, words; ethnography of reception) and quantitative methods (tweets and web analytics).
By elucidating how these series are conceived by their creators and audiences, DEMOSERIES thus aims to understand if and how they might play a crucial role in building the awareness necessary for the safety of individuals and societies, and in creating shared and shareable values in the EU and beyond.
METHOD FOR PRODUCING A BIOCOMPATIBLE IMPLANT, AND IMPLANT

The present invention provides a method for producing a biocompatible implant and a corresponding biocompatible implant. The biocompatible implant (10) has a main implant part (8) that consists of a polyaryletherketone plastic material, the main implant part (8) having at least one first porous portion (12) and a second porous portion (13), the first porous portion (12) and the second porous portion differing in porosity.