SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Increased Frequency of Antigen-Specific Polyfunctional T Cells in Tuberculosis Patients

This study assessed the polyfunctional T cells in healthy household contacts (HHCs) and TB patients. This study also assessed the memory subsets responsible for the secretion of IFN- γ during the short-term culture with Mycobacterium tuberculosis antigens. Frequencies of CD4 + IFN- γ + TNF- α + T cells and CD8 + IFN- γ + TNF- α + T cells specific to M. tuberculosis antigens were significantly higher in TB patients compared to HHC. IFN- γ -secreting T cells, during overnight stimulation with M. tuberculosis antigens, belonged to effector memory subset with a CD45RA − CD27 − phenotype. However, the number of IFN- γ -secreting effector memory cells did not differ between HHC and TB patients.
Regulation of (adp-ribosyl)ation signalling in the dna damage response: elucidating the function of a novel parp1/artd1 interactor

(ADP-ribosyl)ation is a dynamic post-translational modification synthesised by PARPs/ARTDs and regulates a diverse array of cellular processes, including the DNA damage response (DDR). The last decade has significantly improved our understanding of the key enzymes involved in (ADP-ribosyl)ation and the cellular pathways they function within. However, our understanding of how these enzymes are regulated is lacking and demands further investigation. In this proposal I seek to redress this.
I have provided promising preliminary data identifying a novel uncharacterised interactor of PARP1 involved in the DDR. I expect that this novel protein will have a fundamental role in PARP1 biology in cells given that the two have co-evolved and form a protein complex in cells. 
I will implement newly available cutting-edge technologies, such as CRISPR-Cas9 and quantitative cell biology approaches, into an interdisciplinary strategy involving genetics, cell biology, structural biology and biochemistry. This strategy will allow me to address the following research objectives: (1) elucidate the function of this protein complex in genome maintenance (2) determine the atomic structure of the complex (3) define the physiological function of the protein complex using genetic mouse models.
This timely and holistic approach will allow me to answer crucial outstanding questions related to the regulation of (ADP-ribosyl)ation signalling for the first time. Consequently, this will be the first mechanistic study of its function and therefore my research objectives are likely to yield original insights into novel aspects of (ADP-ribosyl)ation signalling.
The objectives described in this proposal will enhance my potential to become an independent investigator by promoting the diversification of my technical competences through training at a world-leading institute and host laboratory. Therefore, the proposal is well aligned with the over-arching aims of the Work Programme.
Intertidal Bathymetry Estimation Using Video Images on a Dissipative Beach

ABSTRACT Sobral, F.N.C., Pereira, P.S., Cavalcanti, P.G., Guedes, R.M.C., Calliari, L.J., 2013. Intertidal Bathymetry Estimation Using Video Images on a Dissipative Beach. Located at southern of Brazil, Cassino beach is a multiple sandbar beach. A video technique to map intertidal bathymetry changes was applied using CMYK color model to find the waterline position, hydrodynamic data and runup 2% (R2) parameterizations. Linear regression between waterline video detected and elevation estimated with in situ measured maximum swash, showed a correlation coefficient of r2=0.82 and r2=0.91, respectively. Rmse values for those comparison was 10.14 m (horizontal detection) and 0.12 m (elevation). The empirical swash coefficient (Kosc) was 1.08 with a total error δz of rms=0.25 m and represents a waterline underestimated to compensate the overestimated horizontal determination. The principal error was found to be at horizontal position, which means that the R2 parameterization was efficient. The estimated bathymet...
An economic analysis of direct marketing of potato and onion in Ludhiana city

The study was undertaken in Ludhiana city of Punjab state to examine marketing cost, price spreads, marketing problems, and to suggest suitable remedial measures to improve the marketing of fruits and vegetables in Apni Mandi. Primary data were collected from 60 farmers, 40 consumers and 20 retailers based on simple random sample without replacement and Secondary data were collected from the office of Market Committee, Ludhiana. Index of Arrivals was calculated and Price spreads were worked out using mode method. Index of arrivals of Ludhiana Apni Mandi was highest in the month of March and lowest in the month of September. Moreover, the study showed that index of income of Market Committee was highest in the month of January and lowest in the month of July. The results showed that the producer's share in consumer's rupee was highest in Apni Mandi for potato (90.00 percent) and onion (94.20 per cent), respectively while it was lowest in the wholesale vegetable market. The study calls for adequate infrastructural facilities to be provided by government for the proper and efficient operation of Apni Mandi. In order to add value for the farmers produce, there should be provision of grading/standardization, branding, labeling, and packing facilities by the concerned body.
Obtaining a Generalized Index of Bank Competitiveness Using a Fuzzy Approach

Abstract The article is devoted to developing a definition of the indicator of the bank’s competitiveness which based on the theory of fuzzy sets and neural networks techniques. Uncertainties that have a place when considering and analyzing the components of evaluating the success and effectiveness of the bank have been considered and analyzed. The sequence of construction and structure for generalizing parameter of bank competitiveness are presented and grounded. Stages of obtaining an integrated assessment of bank competitiveness by sequential application of fuzzy logic and neural networks approaches are determined and described. Corresponding fuzzy terms, membership functions and fuzzy inference rules are described. Overall sequence and steps to resolve the problem are processed. The practical implementation of the summary fuzzy inference of the bank’s competitiveness is given. In particular, numerical calculations on the proposed model for Ukrainian commercial bank “Khreshchatyk” was carried out. Comparison of obtained evaluation results for the competitiveness of specified bank with available data and other scientific information sources showed their compliance with factual situation. In this way, the expediency of application fuzzy modeling has been confirmed to determine the generalized indicators of bank competitiveness. Adequacy and accuracy of the proposed model and the results of calculations were proved. The proposed approach is quite general. This or similar model can be successfully used in other tasks of building and generalized evaluation of integrated indicators for the presence of several local, individual parameters for different economic processes and tasks.
Sense - a roadmap for the ideal low light level sensor development

Over the last decade substantial improvements were made in the technologies for low light-level detection. It is expected that the coming years may bring a technology revolution in this emerging FET-relevant topic. Various European research groups have played and will play an important role in further advancing this technology since low light-level detection is very important for a lot of research projects and upcoming research infrastructures. Indeed, R&D in this technology is growing and new groups all over Europe and world-wide are getting involved. However, a coordination of these groups – especially in Europe – is currently missing; while competition is often speeding up developments especially in the prototyping together with industry, duplication in testing and evaluating available devices for research projects is unfortunately standard.

The project’s objectives are to
(1) conduct the development of a European R&D roadmap towards the ultimate low light-level (LLL) sensors, and to monitor and evaluate the progress of the developments with respect to the roadmap,
(2) coordinate the R&D efforts of research groups and industry in advancing LLL sensors and liaise with strategically important European initiatives and research groups and companies world-wide, (3) transfer knowledge by initiating information and training events and material, and
(4) disseminate information by suitable outreach activities.
Bridging the Chemical and Biological Catalysis Gap: Challenges and Outlooks for Producing Sustainable Chemicals

Recent advances in metabolic engineering have allowed for the production of a wide array of molecules via biocatalytic routes. The high selectivity of biocatalysis to remove functionality from biomass can be used to produce platform molecules that are suitable for subsequent upgrading over heterogeneous catalysts. Accordingly, the more robust continuous processing allowed by chemical catalysis could be leveraged to upgrade biologically derived platform molecules to produce direct or functional replacements for petroleum products. Herein, we highlight recent results that utilize a combination of chemical and biological catalysis, and using the perspective of heterogeneous chemical catalysis, we identify challenges that need to be addressed to bridge the gap between the two catalytic approaches. Specifically, studies are required to address the effects on catalyst performance of impurities that originate during bioprocessing. In addition, new generations of heterogeneous catalysts are required for stable op...
Hindu nationalism and fascism in western india, 1920-1939

HINDUTVA-FASCISM proposes a new study of the transnational links between emerging Hindu nationalism (Hindutva) and contemporary European fascism in the 1920s-30s. Comprehending Hindutva as a form of populist extremism, through examining these thinks the project aims at a better understanding of the transnational nature of the radical populist right in the interwar period; and through this it seeks a better understanding of the radical right in comparative and historical perspective, and of global fascism as a concept. This project speaks to areas of vital current concern for the European Union. It reflects the Horizon 2020 Work Programme’s response to the challenge of fostering ‘inclusive, innovative and reflective societies’, itself a response to the remarkable growth in populist movements in Europe and globally in recent years.
It refers in particular to the European Union policy on 'Racism and Xenophobia’ under its strategic priority of Justice and Fundamental Rights. The relationship between Hindutva and fascism, which emerged at the same time, has been subject to recent work, not least because of its timeliness to India’s own politics, and rise to power of the Hindu Nationalist Bharatiya Janata Party (BJP) since 2014. But this work lacks a focus on the geographical and cultural area which gave birth to Hindutva: Maharashtra, its western Indian heartland, which gave rise to its major institutions and founding ideologues.
HINDUTVA-FASCISM fills this major gap in knowledge exhibited in the current state-of-the-art, proposing a vernacular study to offer in-depth insights on this relationship in Hindutva’s birthplace for the first time, and which the Experienced Researcher is expertly placed to undertake. The project is also innovative in blending regional and linguistic expertise with an interdisciplinary study of other aspects of vernacular culture to form a totalizing, holistic understanding of its regional political culture in the 1920s-1930s.
Fossil musk turtles (Kinosternidae,Sternotherus) from the late Miocene–early Pliocene (Hemphillian) of Tennessee and Florida

ABSTRACTThe oldest fossil musk turtles, genus Sternotherus, are reported from the Hemphillian of eastern Tennessee and central Florida. Sternotherus palaeodorus, n. sp., is known from five partial shells discovered at the late Miocene–early Pliocene (7–4.5 Ma; late Hemphillian) Gray Fossil Site in Washington County, Tennessee. Sternotherus palaeodorus possesses an enlarged intergular scute, wide first vertebral scute that overlaps peripheral set 1, posteriorly extensive hypoplastron to peripheral 7 contact, and a posteriorly situated inguinal musk duct pore (characteristics more typically seen in Kinosternon). A cladistic analysis recovered S. palaeodorus within crown group Sternotherus in the strict consensus and on the stem of Sternotherus in the majority rule consensus. Sternotherus bonevalleyensis, n. sp., from the Palmetto Fauna (5.5–5 Ma; late Hemphillian) of central Florida was perhaps contemporaneous with S. palaeodorus and is known only from isolated shell fragments. It is morphologically most si...
Contrato Jan De Nul Bélgica — entrega de 156 módulos de casa de banho a um cliente chinês.

O projeto diz respeito ao apoio do empresário no fornecimento de liquidez financeira e ao apoio às atividades atuais devido às dificuldades financeiras sentidas pelo empresário em resultado do surto de COVID-19. Assistência financeira prestada ao abrigo do programa n.º SA.57015 (2020/N)
Reasons selectors give for accepting and rejecting medical applicants before interview

The introduction of aptitude testing in the selection of applicants for medical and dental school, in the UK, has led to growing scrutiny of current selection practices. There is increasing difficulty in discriminating between the high numbers of very able candidates who apply to study medicine based on traditional academic criteria. Concerns have been raised that the current selection methods of screening Universities and Colleges Admission Service (UCAS) forms in the UK and holding interviews are essentially subjective and their abilities to predict success at medical school are largely unknown. In particular, questions on the validity and reliability of screening students' personal statements are highlighted.This study aims to further examine this subjectivity and elucidate the reasons given by selectors in one medical school for accepting or rejecting candidates, prior to interview, based on the screening of UCAS forms.Three focus groups, totalling 17 participant selectors, explored current selector practices at one London-based medical school. Additionally, reasons given on selector marking forms for rejecting candidates prior to interview were analysed by content analysis. Data were then triangulated with themes derived from the focus groups exploring why selectors accepted or rejected candidates for interview.Selectors identified clear criteria for selecting or rejecting candidates for interview. They described the 'ideal' candidate as one who possessed positive attributes, including academic ability, enthusiasm and motivation. These views correlated with the reasons for rejecting candidates given by selectors on selector marking forms.This study describes selector practice in one medical school and clarifies selector reasons for accepting or rejecting candidates for interview. Although it provides criteria for the 'ideal' candidate, this study highlights the subjective nature of the selection process and the difficulties in quantifying applicant aptitude, and raises the need for a more open, transparent and reliable way of selecting future medical students.
The complete chloroplast genome of Armand pine <i>Pinus armandii</i>, an endemic conifer tree species to China

The complete chloroplast genome (cpDNA) sequence of an endemic conifer species, Armand pine Pinus armandii Franch., is determined in this study. The cpDNA was 117,265 bp in length, containing a pair of 475 bp inverted repeat (IR) regions those distinguished in large and small single copy (LSC and SSC) regions of 64,548 and 51,767 bp in length, respectively. The cpDNA contained 114 genes, including 74 protein-coding genes (74 PCG species), 4 ribosomal RNA genes (four rRNA species) and 36 transfer RNA genes (33 tRNA species). Out of these genes, 12 harbor a single intron and most of the genes occurred in a single copy. The overall AT content of the Armand pine cpDNA was 61.2%, while the corresponding values of the LSC, SSC and IR regions were 62.0%, 60.2% and 62.7%, respectively. A phylogenetic analysis revealed that P. armandii chloroplast genome is closely related to that of the P. koraiensis within the genus Pinus.
Yan Fu and the language of liberty: beyond translation

This paper examines the late 19th and early 20th century work of the translator and writer Yan Fu (1854-1921), who was among the very first writers to introduce ideas of freedom and democracy in China. I survey his understandings of these terms, drawing particular attention to the methodologies he offers for importing these ideas. Specifically, Yan does not seek to “translate” these ideas, or use them to gain more sensitively calibrated self-understanding. Rather, he thinks quite carefully about how to mobilize them from one site to another in an adequate, efficacious, meaningful way. For Yan, democracy and freedom were the key to enabling China to produce the specific forms of knowledge that could offer strength in an increasingly threatening world. Unfortunately, their dependence on other Western cultural practices and characteristics frustrates their transportability. Yan thus argues for, and exemplifies, a new kind of cross-cultural engagement that does not translate or describe the ideas of a foreign community in his own terms, so much as it enables the formation of new utterances responsive to and coherent within differently-centered communities of argument. What results, I argue, is form of engagement that is ironically more democratically oriented than many current methods put forward in political theory to acknowledge otherness.
Enhancing fiware collaboration between europe and mexico

FIWARE Mexico aims at enhancing FIWARE-driven collaboration between EU and Mexico, based on the adoption, deployment and improvement of FIWARE in Mexico as a framework that will open up new horizons for future cooperation in the ICT domain. The Mexican FIWARE Lab node operated by INFOTEC is part of the FIWARE infrastructure, which facilitates the use of the FIWARE platform for local innovative players. However, to bring new Mexican players into the FIWARE arena and create a sustainable collaborative environment between Europe and Mexico, it is necessary to set and manage the proper conditions needed to support the pillars of FIWARE in Mexico to go beyond the Lab initiative. 
FIWARE Mexico proposes a new approach to actively and strategically engage all relevant stakeholders in supporting the uptake of FIWARE technologies for sustainable collaboration between EU and Mexico. The project will establish Working Groups to engage innovators from the industry, research communities and end users, such as Smart Cities players, in the FIWARE ecosystem. In parallel, dedicated FIWARE technology’ training programmes will be implemented for developers, integrators and contributors, embracing the whole open source community, which will facilitate the adoption of FIWARE technologies and the development of applications to be commercialized in Mexico and EU. Also FIWARE Mexico will focus on key aspects that until now have only partly been addressed in the EU-Mexico policy dialogue, such as the identification of ICT priorities and FIWARE topics of strategic interest for future R&I collaboration.
The FIWARE Mexico consortium is in a unique position to leverage the required expertise, foster engagement with key players, ensure a shared vision, encourage networking, reach a wide range of policy-makers, industrial and economic leaders throughout EU and Mexico, and mobilize resources towards result-oriented actions that will significantly reinforce the EU-Mexico collaboration in FIWARE.
Efficient material hybridization by unconventional layup and forming of metals and composites for fabrication of multifunctional structures

LAY2FORM will create a new cost-effective multistage manufacturing platform based on flexible machinery concepts, cognitive automation, inline monitoring and inspection, as well as simulation and modelling, enabling the efficient integration of unconventional technologies (laser and ultrasound) in established composites-based processes, namely tape-laying and hot-forming, to enable the production of multifunctional 3D hybrid parts from thin layered metals and thermoplastic-matrix composites. Framed by an end-to-end engineering approach, LAY2FORM will shorten the design and manufacturing cycle time and improve reliability, presenting a substantial potential to, in the middle term, turn the manufacturing of complex and intricate hybrid composite-metal parts highly cost competitive. The enhanced LAY2FORM manufacturing system will be a system of systems, containing the enabling process modules and digital sub-systems to create a continuous and automated manufacturing chain. Moreover, LAY2FORM will apply an integrated and systemic approach to implement full manufacturing routes and create new value chains, from materials conditioning to materials disassembly, being a robust basis for the efficient production of hybrid lightweight structures. The multidisciplinary approach proposed in LAY2FORM comprises a complex interconnection of leading R&I topics to develop an industrially-feasible and competitive manufacturing platform, compatible with the Industry 4.0 vision.
Totemism and food taboos in the Early Neolithic: A feast of roe deer at the Coneybury "Anomaly", Wiltshire

Examining the ways in which materials are deposited in Early Neolithic pits – be they artefacts, animal or human remains – still poses interpretational difficulties even for the modern theorist. Working through the detail of the Coneybury ‘Anomaly’ in Wiltshire, this paper focuses specifically upon the character of the depositional practice evident at this site within the Earlier Neolithic (c. 3850 cal. BC), and attempts to define how we might comprehend the pit as a form of totemic practice. Acts of feasting, like the one evident at the ‘Anomaly’ would have shaped the ways people conceptualised certain animals, with symbolic significance of particular species changing through time. Especially during the Earlier Neolithic, cattle began to predominate in the structures’ contexts, with certain species such as deer being underrepresented, perhaps because they were not domesticated. Alternatively wild species such as deer may have been subject to formal taboo.

To fully contextualise my argument, I will be using analogies from the many religions of Amazonia and neighbouring regions of South America, who may be classed as totemic or perspectivist. For many of these people deer are proscribed, considered scared, used in shamanic performances and appear in an anthropomorphised form. Can we work these concepts through the Neolithic material? This paper will consider the effects of possible ideological behaviour at the Coneybury ‘Anomaly’ – especially in relation to the patterns of wild deer deposition. In this, I aim to identify some of the potential archaeological correlates of Neolithic taboos, and through this begin to offer possible ways of understanding the missing link – why were deer not domesticated?