SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Establishing Clinical End Points of Respiratory Function in Large Animals for Clinical Translation

Respiratory dysfunction due progressive weakness of the respiratory muscles, particularly the diaphragm, is a major cause of death in the neuromuscular disease (NMD) X-linked myotubular myopathy (XLMTM). Methods of respiratory assessment in patients are often difficult, especially in those who are mechanically ventilated. The naturally occuring XLMTM dog model exhibits a phenotype similar to that in patients and can be used to determine quantitative descriptions of dysfunction as clinical endpoints for treatment and the development of new therapies. In experiments using respiratory impedance plethysmography (RIP), XLMTM dogs challenged with the respiratory stimulant doxapram displayed significant changes indicative of diaphragmatic weakness.
Development of a sensor with wide spectrum sensitivity for monitoring of damage and defects in composite structures

Shocks on a composite structure of an aircraft can propagate and generate delamination at a distant place. There is currently no other method than regular inspection of the structure to detect these delamination, which requires to immobilize the aircraft. The SWISSMODICS project ambitions to answer the lack of efficient diagnostic tools by providing a miniature, ultra-thin camera to be incorporated in the composite structure of an aircraft where delamination risk to occur. This will considerably facilitate diagnostic and reduce immobilization time, even allowing in-operation diagnostic.

The SWISSMODICS project will develop a camera sensitive to X-ray, visible and infrared light. This will be achieved by creating a monolithic detector made of a CMOS pixel array with configurable pixels to the specificity of each wavelength range, covalently bonded to an absorber with areas sensitive to these 3 different wavelength ranges. The detector will be tested on a panel of section of fuselage in composite, with delamination defects representative of real defects.

The work will be executed by a consortium of 3 companies with complementary competences. CSEM, in Switzerland will develop the CMOS integrated circuit. G-ray, also in Switzerland, will develop the absorber with areas sensitive to different wavelength ranges and will perform wafer to wafer covalent bonding between the CMOS wafer and the absorber wafer. Finally, Almay, a French engineering company with experience in composites for the aeronautical applications, will provide guidance and will integrate and validate the detector on composite structures with defects.

This new sensor will be a breakthrough in non-destructive testing and will open the door to ""intelligent"" composite structures. In aeronautics, it will not only reduce immobilization time but also enable to reduce the security margin on composite parts thanks to continuous monitoring, resulting in economy of weight and fuel.
Examination of iodine status in the German population: an example for methodological pitfalls of the current approach of iodine status assessment

Preliminary iodine concentration (UIC) measurements in spot urines of the representative German adult study DEGS indicated a severe worsening of iodine status compared to previous results in German children (KiGGS study). Therefore, we aimed to evaluate adult iodine status in detail and to investigate the impact of hydration status on UIC.UIC and creatinine concentrations were measured in 6978 spot urines from the German nationwide DEGS study (2008-2011). Twenty-four-hour iodine excretions (24-h UIE) were estimated by relating iodine/creatinine ratios to age- and sex-specific 24-h creatinine reference values. Urine osmolality was measured in two subsamples of spot urines (n = 100 each) to determine the impact of hydration status on UIC.In DEGS, median UIC was 69 µg/L in men and 54 µg/L in women, lying clearly below the WHO cutoff for iodine sufficiency (100 µg/L). Estimated median 24-h UIE was 113 µg/day, accompanied by 32 % of DEGS adults, lying below the estimated average requirement (EAR) for iodine. Comparative analysis with the KiGGS data (>14,000 spot urines of children; median UIC 117 µg/L) revealed a comparable percentage <EAR (33 %). In two DEGS subsamples with significantly different UIC but similar median 24-h UIE, osmolality was twofold higher in the high- versus the low-UIC group.Over 30 % of participants in the two German surveys had an estimated iodine intake less than the respective age-group-specific EAR. Our data strongly suggest that even in large surveys, hydration status can considerably interfere with the epidemiological iodine assessment parameter UIC. The present data can serve as an example how to evaluate population-based spot urine data on a 24-h basis, independent of hydration status.
Ruthenium-Based photoactivated chemotherapy against eye cancer

The Ru4EYE PoC proposal will develop the first pre-clinical evaluation of Ru-based PACT compounds in uveal melanoma (UM) model. UM is a rare malignancy of the eye. Although treatment against UM do exist, they do no always preserve vision or the eye, and often lead to patient death via metastasis to the liver. A better treatment that would save vision, the eye, and the patient, is looked after. UM appears as an appealing disease for photoactivated chemotherapy (PACT), a new form of phototherapy developed within my ERC Starting Grant RuProLight. PACT agents are photosensitive compounds that can kill cancer cells selectively under the action of light. In PACT dioxygen does not need to be present at the site of light irradiation because the mechanism of photochemical activation is an oxygen-independent bond breakage reaction between a bioactive, cytotoxic agent, and a light-removable protecting group. Innovative therapeutic solutions such as PACT are typically difficult to bring to the market because of the risky nature of drug development and the funding required for clinical trials. The vision in this grant proposal is that positive results on a rare form of cancer such as uveal melanoma could not only offer a relatively short-term solution to uveal melanoma patients, but also accelerate translation of Ru-based PACT to the clinics by driving developments for other diseases as well. The biological testing of Ru-based PACT compounds will be performed in a complete series of translational cancer models: from in vitro (2D monolayers of normoxic and hypoxic cancer cells, 3D tumor spheroids) to in vivo (xenografts in zebrafish embryo for studying metastasis formation and treatment, and mouse model for in vivo toxicity and efficacy). The aim is to develop a pre-clinical proof-of-concept that PACT can be used to treat uveal melanoma, so that presentation to venture capital and clinical testing can start quickly after completion of the project.
Durs Grünbein. Un’idea di Dante 3D

Il saggio esamina alcuni contributi pubblicati dal poeta Durs Grünbein in occasione del settimo centenario della morte di Dante. Particolare attenzione viene dedicata alla terzina di Paradiso XXXIII, vv. 94-96 che impegna il poeta tedesco almeno dal 2009. In base alla terminologia impiegata da Grünbein per descrivere le sue trasposizioni dantesche in termini di rendering, il saggio indaga l’influenza del Sommo Fiorentino nella poetica dell’autore di Dresda alla luce dell’era globale-digitale per risalire alle fonti dell’ispirazione poetica, dove Grünbein rilegge Dante con Cartesio e Mandel’štàm.
CULTURE METHOD FOR DIFFERENTIATING PRIMORDIAL GERM CELLS INTO FUNCTIONALLY MATURE OOCYTES

The present invention addresses the problem of providing a method for differentiating primordial germ cells into functionally mature GV stage oocytes by in vitro culture. The present invention pertains to a method for differentiating primordial germ cells into functional GV stage oocytes in vitro including (a) a step for forming secondary follicles by culturing primordial germ cells and feeder cells adjacent to the primordial germ cells under conditions that eliminate the effects of estrogen or factors having a similar function to estrogen, (b) a step for partially cleaving the bonds between the granulosa cell layer and the thecal cell layer among the oocyte, granulosa cell layer, and thecal cell layer that constitute the formed secondary follicles, and (c) a step for differentiating the oocytes into functional GV stage oocytes by culturing the oocytes and granulosa cell layer that constitute the secondary follicles and the thecal cell layer in medium including a polymer compound.
DEVICE FOR JOINING A MODULAR BLADE

The invention relates to a device for joining a modular blade, the joint being formed by a plurality of bolts (8) that are secured between inserts (3 and 4) housed in the composite material of two modules (1 and 2) to be joined. The device allows the bolt (8) to be preloaded with less application force and greater precision than known systems, also ensuring that the device is maintenance free. For this purpose, each device is formed by lateral caps (9), an upper wedge (10) and a lower wedge (11), and transverse screws (12), all of this surrounding the corresponding bolt (8) disposed inside of a hole between two blade modules (1 and 2). When a force F1 is applied to the wedges (10 and 11), the caps (9) respond with a force that separates the modules (1 and 2) and pre-stress the bolt (8).
ELECTRICAL GENERATION SYSTEM BASED ON TIDAL FLOW

An electrical generation system based on tidal flow includes a reservoir and a fluid inlet tube extending between a tidal source and the reservoir. The inlet tube has at least one inlet turbine generator disposed therein. The fluid inlet tube extends along a first level. A fluid outlet tube extends between the reservoir and the tidal source. The fluid outlet tube has at least one outlet turbine generator disposed therein. The fluid outlet tube extends along a second level vertically lower than the first level. During high tide at the tidal source, tidal fluid flows from the tidal source, into the fluid inlet tube, past the at least one inlet turbine generator, and into the reservoir and during a low tide at the tidal source, the tidal fluid flows from the reservoir, into the fluid outlet tube, past the at least one outlet turbine generator, and to the tidal source.
Heritage for Innovative and Sustainable TOurist Regions in Italy and Croatia

The aim of this project is a landscape design for creating an “Historical walk through”.  The partners have selected 4 pilot areas to be valorised with innovative tools following a common approach.  Including Augmented Reality, virtual and web applications of touristic product and social route tracking, the project will contribute to the development of a responsible, sustainable and innovative tourism. This type of Cultural Heritage valorization will enrich the tourist offer creating a recognizable tourist attraction that would attract guests out of main season.

Information added on 2020-12-07, regarding the mitigation of the effects of COVID-19 (the coronavirus pandemic that started in 2019) (English language only): Our efforts are aimed at contributing to sustainable tourism, even more important during the pandemic which has strongly affected the tourist sector. It created more interest in the project goals as the newly coming scenario demands new strategies and approaches to sustainable development led by the exploitation of cultural resources.
Energy Development and Addressing Climate Change in China

China's current economic and social development not only has been constrained by the bottleneck of resources and environment,but also has been challenged by global climate change and mitigation of carbon emissions.After promoting energy conservation and reducing CO2 emissions vigorously,China has archived the great reduction rate of CO2 intensity of GDP,which has caught the world's attention.However,because of rapid growth of GDP during the industrialization stage,CO2 emissions in China will be high and grow fast.China coordinates sustainable development and addressing global climate change to achieve the green,low carbon development.China will take following measures: to strengthen the strategic adjustment of industrial structure and industrial upgrade and to promote structural energy conservation;to promote energy-conservation technology,to eliminate backward production capacity and to improve energy efficiency;to develop new and renewable energy,to optimize energy structure and to reduce carbon ratio of energy structure.China's main objective in the near future is to significantly reduce the energy intensity of GDP and CO2 intensity,to take efforts to reach CO2 emissions peak in 2030 and to significantly decrease them in 2050,in order to adapt to the long-term emission reduction goal of keeping the global temperature rise of less.During Twelveth Five Year Plan period,China will take more efforts to control the total energy consumption,to establish the statistics,accounting and evaluating systems of CO2 emissions and to promote the carbon trading market mechanisms.All these means will also accelerate the transfer of economic development pattern.
Bag for Boat Livewell

A bag for boat livewell for providing efficient removal and transport of fish from a boat's live well. The bag for boat livewell generally includes a bag having a floor, an upper opening opposite of the floor, a first sidewall extending from the floor, a second sidewall extending from the floor, a first end wall extending between the first sidewall and the second sidewall, and a second end wall extending between the first sidewall and second sidewall. The bag is constructed of a water permeable material. A first handle and a second handle extend from the first sidewall and the second sidewall respectively. A first interior closure and a second interior closure are attached to the sidewalls for selective closing of the upper opening. A first buoyant member and a second buoyant member are attached to the first sidewall and the second sidewall respectively.
Technology and political change: nuclear power in the post-soviet union

Focusing on the case of nuclear power in post-Soviet Russia and Ukraine (1990-present), this research and training project analyzes the relationship between political elites, scientific experts and the public in the context of political change and incomplete democratization. The project will move beyond existing studies and analyze the co-evolution of risky technologies and political systems in transition. To date, research on political transition in Russia and Ukraine has not sufficiently taken into account science and technology (S and T). Similarly, the analysis of S and T has been disconnected from changes in political institutions and practices. This project will consider how Ukrainian and Russian policy makers and specialists have navigated new political circumstances and forms of public engagement to advance nuclear power programs. It will study how nuclear technologies are governed, how they are received in society, and evaluate public controversies over costly and potentially risky large scale technological systems. This research has relevance for Horizon 2020 concerning reliable and clean energy, as well as the impact of technopolitical change on the European periphery on Europe's energy, security and integration. 
The project will be based at Universitat Pompeu Fabra (UPF) under supervision of Albert Presas Puig, a specialist in the history of nuclear energy in Europe and in science under Francoism. It's integration into the UPF system will create synergies with scholars who study authoritarianism and science, nuclear power, European integration, and the public and science, and situate the Russian and Ukrainian experience into the larger European experience. The project includes undergraduate and graduate teaching in the domain of science, technology and politics; develops strategies with regard to academic writing and publishing and enables outreach of researcher's expertise both with academics and concerned citizens in European Union and its periphery.
Nonlinear observability and identifiability of single cells in battery packs

Lithium-ion batteries currently offer the best tradeoff between objectives like performance, energy density and lifetime. To serve the demands of many applications, often a large number of single battery cells are combined into modules or packs of batteries. However, the determination of state of charge and parameters of the single cells is important for the reliable and safe operation of batteries. In the present paper, we investigate the observability and identifiability of cells in battery packs, realized in parallel and serial connections. The analysis is based on linear and nonlinear observability tests exploiting an equivalent circuit model. This leads to conclusive findings concerning the feasibility of estimating the states of single cells from lumped measurements. As shown for cells in parallel connection, one voltage and one current sensor are sufficient to determine state of charge and model parameters of the individual cells. The results are illustrated by simulations.
Promotion of Multifunctionality of the Agro-tourism sector

A partnership of different actors initiated this project: Regione Toscana as the leader, policy strategy holders Laore and Avitem Agencies, know-how holders QUINN and University of Sassari and CCIAS, representing businesses. PROMETEA will take on three challenges. Firstly, it will support innovation in micro, small and medium-sized companies and young people's self-entrepreneurship, especially young women. Secondly, it will promote business networks that will offer integrated eco-tourism services and experiential tourism routes to meet the growing demand for quality and environmental awareness coming from rural users. Thirdly, it will identify a common cross-border approach for the definition of a quality brand. To meet these challenges, PROMETEA will identify, design and promote multifunctional entrepreneurial models geared towards social innovation and sustainability. It will be strengthening the knowledge system of the target group through the formulation of innovation training paths and self-entrepreneurship courses in universities, stipulating joint protocols for the introduction of network contracts and the role of "network manager" to facilitate SME networking. Networking will promote non-seasonal eco-tourism routes and connect coastal, rural and urban areas. Modelling and networking will not be the only elements of the innovation; another will be the method adopted to approach the acquisition of a shared quality brand. It will be a collaborative approach, including a cross-border participatory planning process (study sessions, guided tours), and involve all project stakeholders
The neurobiological and computational origins of behavioral variability

Human behavior is inherently variable. Even when faced with the same exact choice options, we often take different actions. The causes for this inconsistency are unknown, but economic and cognitive theories assume this is due to noise that is injected when making a decision. However, I have recently demonstrated that noise might not just arise during the decision process, but that the learning process itself (i.e update of internal representations based on feedback) is subject to substantial and meaningful noise. Concretely, I have shown that noise during learning accounts for the majority of what is traditionally reported as ‘decision noise’. However, the neural mechanisms underlying this learning noise remains unknown. In this fellowship, I will examine the contributions of the locus coeruleus-noradrenaline (LC-NA) system to this learning noise. NA has previously been associated with decision noise and here I will test whether activity in the LC is the driving factor behind learning noise. I will use a cutting-edge real-time fMRI framework that allows to causally test whether ongoing LC activity directly influences learning noise. Moreover, I will examine whether this learning noise is relevant to impulsivity, which has previously been implicated in decision noise. This fellowship has the potential to overthrown the traditional view on behavioral variability in decision making and will provide a novel neurobiological, computational and psychiatric grounding for understanding why humans are consistently inconsistent.
Thermodynamic nature of the0–πquantum transition in superconductor/ferromagnet/superconductor trilayers

In structures made up of alternating superconducting and ferromagnet layers (S/F/S heterostructures), it is known that the macroscopic quantum wavefunction of the ground state changes its phase difference across the F--layer from 0 to PI under certain temperature and geometrical conditions, whence the name "0-PI" for this crossover. We present here a joint experimental and theoretical demonstration that the "0-PI" is a true thermodynamic phase transition: microwave measurements of the temperature dependence of the London penetration depth in Nb/Pd_0.84Ni_0.16/Nb trilayers reveal a sudden, unusual decrease of the density of the superconducting condensate (square modulus of the macroscopic quantum wavefunction) with decreasing temperature, which is predicted by the theory here developed as a transition from the 0- to the PI-state. Our result for the jump of the amplitude of the order parameter is the first thermodynamic manifestation of such temperature-driven quantum transition.
Resenha: ROCHA, Darllan Neves da. Mestres do barro: patrimônio, turismo cultural e kitsch no Alto do Moura. Salvador, BA: Editora Segundo Selo, 2020.

Esta resenha versa sobre o livro “Mestres do barro: patrimônio, turismo cultural e kitsch no Alto do Moura”, que foi escrito por Darllan Neves da Rocha. No qual, o autor descreve analiticamente as relações engendradas no fazer com o barro e como elas se desdobram em arte, artesanato, patrimônio e turismo cultural (etnoturismo e kitschturismo) no bairro rural do Alto do Moura, município de Caruaru, Pernambuco. Ele apresenta ainda os mestres da arte com o barro, os seus discípulos e os demais legados, que permanecem dinamicamente vivos na localidade, bem como aborda a organização social do grupo, sobretudo, a existente em torno do turismo. A presente resenha aborda as escolhas teóricas metodológicas do autor, resume de forma analítica os três capítulos que, respectivamente, tratam sobre o grupo e sua história, os patrimônios e o turismo cultura. Conclui-se que a obra Mestres do barro estabelece debates teóricos com a produção existe sobre turismo e patrimônio, nestes campos, contribui com categorias analíticas inovadoras. Além disto, enquanto uma etnografia, proporciona conhecer o Alto Moura e sua intrincada tessitura sociocultural.