SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
No effect of co-administered antiepileptic drugs on in-vivo protein binding parameters of valproic acid in patients with epilepsy

Abstract Objectives The aim of this study was to establish the population protein binding parameters of valproic acid (VPA) in patients with epilepsy receiving VPA monotherapy and those receiving VPA combined with other antiepileptic drugs. Methods One hundred and thirty nine data sets from 63 Japanese patients with epilepsy were analysed. These patients were separated into two groups: VPA monotherapy and VPA combined with other binding-sensitive antiepileptic drugs, including phenytoin, clonazepam, clobazam, carbamazepine and phenobarbital (VPA polytherapy). The population protein-binding parameters of VPA were obtained by non-linear least-squares method in each group. Key findings The mean (95% confidence interval) dissociation constants were 38.9 µm (33.2–44.6 µm) and 36.9 µm (26.7–47.1 µm), and the numbers of binding sites were 1.36 (1.27–1.44) and 1.33 (1.19–1.47) in the monotherapy and polytherapy groups, respectively. No significant differences in the binding parameters of VPA to serum albumin were observed between the two groups. Conclusions The steady-state serum albumin binding of VPA in Japanese patients with epilepsy is not affected by co-administration of other antiepileptic drugs. These findings suggest that serum VPA concentration is stable at the steady state with regard to interaction by protein binding, even when other antiepileptic drugs with moderate-to-high binding properties are co-administered.
WEARING SURFACE FOR TYRES FOR WINTER CONDITIONS

A wearing surface for tyres, especially for use on icy roads, of the kind where the rubber or rubber mix is supplied with an admixture of friction improving materials. The friction improving materials constitute approximately 20-60 % by weight of the rubber mix, and consist of a mixture of crystalline chrysolite (olivine) powder and a metal powder, being for example a steel powder and/or a powder from an aluminium alloy, and if desired an additional friction supporting material having good binding force to the rubber mixture.
Transepiseed: the role of mrna methylation in control of seed germination

Seed germination is a unique phase of the plant life cycle. Its correct coordination is crucial for seedling establishment, and germination is, therefore, key for crop survival and yield. The improvement of seed germination will be highly important for modernized precision agriculture.
Seeds accumulate a substantial amount of translationally inert mRNA during maturation. These mRNAs have a strikingly long half-life allowing seeds of certain plant species survive up to thousands of years. Upon water-uptake, these mRNAs are translationally activated in support of seed germination. The function of mRNAs stored in dry seeds has been a mystery for decades. My recent work demonstrated that these stored mRNAs are associated with ribosomes and that they get translated during early seed germination. Therefore, an understanding of the regulatory mechanisms that govern the storage of these mRNAs in dry seeds, and their eventual translation upon germination will reveal tremendous insight into seed germination.
A multitude of mechanisms might affect mRNA translation. Common to them is that they must involve sequence-specific recognition of a signal within the transcript, such as an mRNA modification. N6-methyladenosine (m6A), the most widespread internal mRNA modification, has been shown to have important role on mRNA stability or translation efficiency involving recruitment of specialized m6A-binding proteins, in plants referred to as EVOLUTIONARILY CONSERVED C-TERMINUS (ECT) proteins. TransEpiSeed aims to study the relevance of m6A for translational control during seed germination by investigation of m6A dynamics and the function of ECT proteins. Combining my knowledge on the translational regulation of seed germination with expertise on m6A of the host lab provides a strong base to increase the insight into the regulation of seed germination. The results will provide opportunities for high-quality seed production and strengthen my skills required as advanced seed biologist.
Quantitative determination of chrysotile in massive serpentinites using DTA: Implications for asbestos determinations

There is increasing concern about the health hazard of asbestos from natural geologic deposits such as greenstones [natural occurring asbestos (NOA)]. Therefore, quantitative determination of the chrysotile asbestos content within massive serpentinites is a recurrent requirement of recent asbestos-inherent law regulations, due to the possible health hazard associated with the release of chrysotile fibers. Unfortunately, the obtainment of accurate and precise quantitative figures of the actual chrysotile content is strongly complicated by typical serpentinite textures, consisting of fine-to-ultrafine intergrowths of fibrous and non-fibrous serpentine minerals, often difficult to identify by conventional methods, such as X-ray diffraction or microanalytical approaches. In this paper, we propose a reliable and straightforward method for the quantitative determination of chrysotile asbestos within bulk massive serpentinites, based on thermal analysis data and, specifically, on the distinctive thermal behavior of chrysotile, lizardite, and antigorite during dehydroxylation at 500–800 °C. Deconvolution processing of DTA endothermic signals in the dehydroxylation temperature range revealed good linear correlation between peak area ratios and chrysotile content, for both lizardite + chrysotile and antigorite + chrysotile samples. The DTA correlation curves have been used to determine the chrysotile content in two test serpentinites, revealing surprisingly high-chrysotile content. This novel method is of vast importance as it represents one of the most promising tools for chrysotile quantitative determinations in massive serpentinites, providing unbiased and accurate responses to recent asbestos-related law requirements.
Aportes de los planes de eficiencia para la transición energética y metodología para sudesarrollo: el caso del sector residencial de Argentina

A eficiência energética tem relevância significativa como política de mitigação e transição energética, proporcionando também benefícios econômicos e sociais. No entanto, muitas das opções de eficiência energética enfrentam diferentes barreiras e, por isso, não são implementadas, exigindo a implementação de planos e programas de políticas para incentivá-las. Este estudo aborda a importância e a necessidade de desenvolver planos de eficiência energética na busca da transição energética a partir da apresentação da proposta de um plano de eficiência energética (PlanEEAr) para o setor residencial na Argentina. O objetivo do trabalho é, a partir de um estudo de caso particular, ilustrar uma proposta metodológica construída para a elaboração de planos de eficiência energética, que combina ferramentas de análise quantitativa e qualitativa, e que permitem avaliar os potenciais de eficiência, seus impactos sistêmicos para o setor energético e ambiental e construir, a partir da identificação de barreiras, propostas de instrumentos que promovam sua implementação. Entre as principais lições do processo, destaca-se a importância de contar com ferramentas que contenham avaliações de potenciais de eficiência, impactos futuros, a relevância de um bom diagnóstico e identificação de barreiras e a construção participativa de propostas de políticas, bem como a necessidade de avançar nos processos de gestão do conhecimento para a implementação das propostas construídas.
Logical partitioning in redundant systems

Provided are a method, system, and article of manufacture, wherein a plurality of processing nodes in a storage system are partitioned into a plurality of logical processing units, and wherein the plurality of logical processing units can respond to I/O requests from a host coupled to the storage system. At least two logical processing units are grouped, wherein data in a first storage coupled to a first logical processing unit of the least two logical processing units is mirrored by data in a second storage coupled to the second logical processing unit of the at least two logical processing units. In response to a failure of the first logical processing unit, an I/O request from the host is responded to via the second logical processing unit.
Automated tube straightening apparatus and method forstraightening a tube

A shaft straightening or tube straightening apparatus (10) and method performing accurate measurements of the linear profile of a metal tube (16), and then correcting small and large deviations of the tube profile from the ideal centerline along the length of the tube (16). The tube straightening apparatus (10) is operable to accurately measure a linear profile of the tube (16) positioned in the apparatus (10). The tube (16) is rotated in the apparatus (10) to locate a pair of low points in the tube profile and a high point of the tube (16) between the two low points. The tube (16) is supported in the apparatus (10) at the pair of low points and the high point of the tube (16) is then deflected beyond the yield point of the metal of the tube (16) to permanently distort the tube (16) and correct the tube's profile.
On the Computational Capabilities of Physical Systems, Part 1: The Impossibility of Infallible Computation

In this first of two papers, strong limits on the accuracy of physical computation are established. First it is proven that there cannot be a physical computer C to which one can pose any and all computational tasks concerning the physical universe. Next it is proven that no physical computer C can correctly carry out any computational task in the subset of such tasks that can be posed to C. As a particular example, this means that there cannot be a physical computer that can, for any physical system external to that computer, take the specification of that external system's state as input and then correctly predict its future state before that future state actually occurs. The results also mean that there cannot exist an infallible, general-purpose observation apparatus, and that there cannot be an infallible, general-purpose control apparatus. These results do not rely on systems that are infinite, and/or non-classical, and/or obey chaotic dynamics. They also hold even if one uses an infinitely fast, infinitely dense computer, with computational powers greater than that of a Turing Machine.
CONVERSION BETWEEN CALIBRATED AIRSPEED AND TRUE AIRSPEED IN TRAJECTORY MODELING

Systems, methods, aircraft, non-transitory media, and memories are provided. An avionics system for an aircraft includes a storage device and one or more data processors. The storage device stores instructions for converting between airspeed types and the one or more data processors is configured to execute the instructions to: generate a calibrated airspeed of the aircraft; convert the calibrated airspeed to an actual true airspeed of the aircraft; determine an initial approximate relationship between the calibrated airspeed and a computed true airspeed as a function of a pressure altitude of the aircraft; generate an adjusted approximate relationship based on the actual true airspeed and the initial approximate relationship at a chosen pressure altitude; and estimate a future airspeed of the aircraft based on the adjusted approximate relationship and a future altitude.
Original Mind and Cosmic Consciousness in the Co-Creative Process

This article will investigate the issue of accessing benxin 本心 (original mind), subsequent operation from Self and, in that process, union with the “greater universe” or benti 本体 (original substance)—a state expressed in the West as “cosmic consciousness.” It is proposed that this allows one to participate as a partner in the creative process of one’s own life and the surrounding world. The equally important question of how to gain contact with original mind will also be addressed, as well as the consequences of doing so with regard to the human condition. The concept of original thought is introduced, being important here as it is held to be that thought which is generated in the pure condition of original mind, devoid of influence from finite physical existence.
Development of a multivariable control system on an experimental platform dedicated to the study of fouling phenomena

This paper presents the development of a multivariable control system for regulation of the physical quantities associated to the fouling phenomena on an experimental platform. This platform is considered as a two-by-two system, i.e., the voltage and current as the inputs system and the flow and pressure as the outputs system. In the Matlab scripts, the plant model was identified as a set of first-order or second-order systems with dead time. Furthermore, the Relative Gain Array (RGA) and Relative Normalized Gain Array (RNGA) were calculated to find the best pairing among loops. The diagonal and off-diagonal pairings were verified by means of PI/PID decentralized controllers, which were designed using the IMC tuning method. At last, the output control performance was evaluated using the ISE performance metric.
KESIAPAN SATUAN KERJA PENGGUNA ANGGARAN PENDAPATAN DAN BELANJA NEGARA DALAM RANGKA E-BUDGETING YANG DICANANGKAN PEMERINTAH PUSAT (STUDI KASUS BPK RI PERWAKILAN PROVINSI DAERAH ISTIMEWA YOGYAKARTA)

In state finance management, use of Information and Communication
Technology (ICT) is realized by e-budgeting. In charge of e-budgeting, Ministry
of Finance (MoF) launched State Treasury and Budget System (SPAN). SPAN is
targeted fully implemented in 2013. Because e-budgeting is focused on the use of
ITC in budgeting process, it needs e-budgeting readiness and acceptance from
state budget spending unit.
The research aims to measure e-budgeting readiness level in The Audit
Board of The Republic of Indonesia (BPK RI) Yogyakarta Special Region (DIY)
Province Representative as well as analyze the effect of technology readiness on
technology acceptance in the e-budgeting context. The models used is Technology
Readiness Index (TRI) dan Unified Theory of Acceptance and Usage of
Technology (UTAUT). The data was collected by questionnaires and interviews.
Data obtained were analyzed using Structural Equation Modeling (SEM) with
help of software SmartPLS version 2.0 M3.
Result indicated that BPK RI DIY Province Representative employeesâ��
readiness level on e-budgeting is pioneer. Data analysis also showed that
dimension optimism effect on performance expectancy dan dimensions
innovativeness, discomfort, dan insecurity effect on effort expectancy. Ebudgeting
acceptance in BPK RI DIY Province Representative is not affected by
employeesâ�� e-budgeting readiness.
A productive, affordable and reliable solution for large scale manufacturing of metallic components by combining laser-based additive and subtractive processes with high efficiency

The overall objective of PARADDISE project is to rationalize, to structure and to make available to the stakeholders of manufacturing value chain the knowledge and the tools for combining two antithetical processes: Laser Metal Deposition (LMD) and Machining (milling and turning). The project will develop expert CAx technologies, smart components and monitoring and control systems tailored for the hybrid process in a cost-effective way and with structured knowledge about LMD process. The PARADDISE solution will offer a synergetic combination among: i) the high flexibility for the designs and for the materials to be used, the high material efficiency and the high savings in material resources and its associated costs of the LMD operations; and ii) the high accuracy, the high robustness and the high productivity of subtractive operations.
The solution will be integrated in the ‘ZVH45/1600 Add+Process’ hybrid machine from IBARMIA manufacturer (PARADDISE partner), which is already available in the market as well as at TECNALIA’s facilities (PARADDISE coordinator). Thus, the PARADDISE project will conceive a process-machine-tools solution. 
By means of this combined manufacturing process, large scale manufacturers of value-added metallic components will be able to achieve high quality and high productivity with a minimum use of material and energy resources when manufacturing those parts, which will lead to a reduction in manufacturing costs. In that way, the PARADDISE project intends to boost and to spread the use of Laser Metal Deposition (LMD) technology along the life cycle of value-adding metal components.
Efficient Ag/CeO2 catalysts for CO oxidation prepared with microwave-assisted biosynthesis

Abstract In this paper, we report a microwave-assisted biosynthesis method with Cinnamomum camphora (CC) leaf extract for the green and rapid synthesis of Ag nanoparticles (NPs). The as-produced Ag nanoparticles were immobilized onto CeO 2 as supported Ag/CeO 2 catalyst, which proved to be efficient for carbon monoxide (CO) oxidation. Active components in the plant extract were identified by FTIR analysis and later on validated through simulated experiments. The results revealed that polyphenols and proteins were the reducing and protecting agents, respectively. The optimum preparation conditions for the catalyst were irradiation time of 140 s, Ag loadings of 5 wt.%, CC extract concentration of 25 g L −1 and sintering temperature of 300 °C. Since biomolecules adsorbed over the surface of catalyst was detrimental to its catalytic activity, calcination to remove the biomolecules was critical to the enhanced activity. Considering the trade-off between particle size and biomass removal extent, the optimum calcination temperature was determined to be 300 °C.
The Basics of Communication Studies

Most chapters begin with and conclude with Summary, For More Information, Review Questions, and Works Cited. 1. Why Study Communication? Definition of Communication Models of Communication Essential Parts of Communication Communication in Context Principles of Communication 2. Perception and Listening Introductory Exercises Why Don't We All See Things the Same Way? Perception and Awareness Perceptual Differences Self-Concept Eyes, Ears, Heart Importance of Listening Kinds of Listening Barriers to Listening Improving Listening Skills 3. Verbal Communication What Is Language? Principles of Verbal Communication Language as an Obstacle to Communication Barriers to Communication Improving Verbal Communication 4. Nonverbal Communication What is Nonverbal Communication? Principles of Nonverbal Communication Types of Nonverbal Communication Improving Your Understanding 5. Intercultural Communication Definition of Intercultural Communication Characteristics of Intercultural Communication Barriers to Intercultural Communication Improving Intercultural Communication 6. Intrapersonal and Interpersonal Communication. What Is Intrapersonal Communication? Maslow's Hierarchy Schutz's Interpersonal Needs Johari Window Social Penetration Theory Coming Together Growing Apart Improving Interpersonal Communication 7. Group Communication. Types of Groups How Groups Meet Our Basic Needs How Many Members Does it Take to Make a Group? Groups Play By Their Own Rules Problem-Solving in Groups How Do Groups Develop? Lifecycles of Groups Why Do People Stay in a Group? Group Members Have Roles to Play When Groups Come Together via Computers Group Members as Leaders 8. Communication at Work What Do You Know Already? What Do You Need to Know? Making Contact You've Got the Invitation to Interview! Effective Communication in Teams and Groups Effective Communication in Meetings Effective Communication in Virtual Meetings 9. Mass Communication What Is Mass Communication? Types of Mass Communication Functions of Mass Communication Effects of Mass Communication Critical Analysis of Mass Communication 10. Speech Preparation How to Choose a Topic Getting to Know Your Audience Conducting Research The Five Parts of any Speech Constructing the Introduction, Conclusion, and Effective Transitions 17 Organizational Patterns for your Speech The Speech to Inform Sample Outline: The Informative Speech The Speech to Persuade Sample Outline: The Persuasive Speech Persuasive Arguments Fallacies in Reasoning Ethics in Communication 11. Speech Presentation What Makes for a Good Delivery? Speaking Effectively Speech Anxiety Nonverbal Communication and Delivery Umms, Ahhs, and Other Speech Disfluencies Effective Notecards and Other Useful Tools Effective Eye Contact Visual Aids: Purpose, Emphasis, Support, and Clarity Types of Visual Aids Methods and Materials Preparing Visual Aids Using Visual Aids Effective PowerPoint Presentations Index
The effects of different CCS technological scenarios on EU low-carbon generation mix

Carbon capture and storage technology (CCS), a technology to reduce the emissions in coal and gas power generation plants, will play an important role in the achievement of the European Union emissions reduction objective. In the European Union, energy policies are articulated around three different elements: measures to promote renewable energy technologies, the emissions certificates system and both energy-saving and energy-efficiency policies. The succession of directives and communications from the EU Commission on renewable technology generation share targets and the implementation of the European Emissions Market exemplify the serious EU commitment to a more environmentally friendly future. CCS technologies—together with RES technologies—are thus key to achieve the European emissions reduction target. Although the CCS commercial availability is not guaranteed—due to a slow technological development—some institutions, such as the Institute for Prospective Technological Studies, assume, for 2030 horizon, a quick development of this technology, growing until a maximum participation of an 18 % over the fossil fuels total generation. An eventual non-availability of these technologies in 2030 could increase the cost of this objective in a 70 %. Therefore, the achievement of pollutant emissions reduction targets depends on a correct design of the European generation technologies mix, which should include CCS technologies. Nevertheless, the uncertainty about the final costs and economic risk of these technologies makes a question about their future role to arise. This paper analyses the effects of different variations in the cost and risk of the CCS technologies (scenarios) over the European power technologies mix. The results confirm the need of the availability of these technologies in 2030, beyond the potential costs and risks of both options. The reason lies in the methodological approach of portfolio theory, which allows an analysis from an efficient portfolio point of view.