SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Encapsulated eukaryotic ribosome assembly

The production of fully functional ribosomes is vital for every cell, with failure causing human diseases called ribosomopathies. Eukaryotic ribosome assembly is catalyzed by ~200 assembly factors that guarantee efficient and accurate production of ribosomal subunits along a temporally and spatially ordered pathway. About one third of these factors are utilized in the formation of the earliest biogenesis intermediate, termed 90S pre-ribosome or small subunit processome. Recent insight into the 90S structure from a eukaryotic thermophile, Chaetomium thermophilum, has provided a first spatial impression on this most sophisticated process, which includes co-transcriptional RNA folding and processing, and incorporation of ribosomal proteins. Our key discovery was that the nascent ribosomal RNA, which if linear would form a long thread, is co-transcriptionally mounted into a mold formed by a highly interconnected RNA-protein scaffold on the 90S pre-ribosome. This finding raises a novel concept in RNA biology that nascent RNA folds and matures in a protected environment, which is reminiscent of protein folding that can also occur in folding chambers. I plan to challenge the idea that the 90S particle indeed encapsulates the RNA transiently, in order to protect it from unproductive interactions, allowing stepwise folding and maturation in a cascade of interdependent reactions and the involvement of energy-consuming enzymes. The groundbreaking aim of this proposal is to decipher how these processes occur in an encapsulated environment, using C. thermophilum as a model organism. This high-risk project will depend on the successful establishment of novel assays that recapitulate eukaryotic ribosome assembly in vitro, exploiting the thermostable nature of the 90S pre-ribosome. Mechanistic insight into ribosome biogenesis will lead to a better understanding of how this multifaceted process is linked to other key cellular pathways and development of diseases including cancer.
Harmonic analysis and differential equations: new challenges

This project sets forth cutting-edge challenges in the field of Mathematical Physics that will be solved within a common framework by making novel use of classical tools of Harmonic Analysis such as Oscillatory Integrals and Trigonometric Sums, the Cauchy operator, and the so-called Carleman estimates. Three aspects will be covered:
1.Vortex Filament Equation (VFE)
2.Relativistic and Non-relativistic Critical Electromagnetic Hamiltonians 
3.Uncertainty Principles (UPs) and Applications
The interaction of vortex filaments is considered a key issue in order to understand turbulence which is seen by many as the most relevant unsolved problem of classical physics. VFE first appeared as an approximation of the dynamics of isolated vortex filaments. I want to understand what happens when at time zero the filament is a regular polygon. Preliminary theoretical arguments together with some numerical experiments suggest that the different corners behave like different vortex filaments that interact with each other in such a way that the dynamics seem chaotic. I will prove the so-called Frisch-Parisi conjecture, showing that behind this chaotic behavior there is an underlying algebraic structure that controls the dynamics.
The Dirac equation, despite being one of the basic equations of Mathematical Physics, is very poorly understood from an analytical point of view. I will use the classical Cauchy operator in a modern way to explain some key Hamiltonian systems such as the MIT bag model for quark confinement.
UPs are at the heart of different fields like Quantum Mechanics, Harmonic Analysis, and Information Theory. We want to use a new approach to analyze modern versions of UPs that are not well understood. In order to do this, I will look at the problem from the point of view of partial differential equations making novel use of the Carleman estimates. This analysis will also be extended to the discrete setting where even classical UPs such the one by Hardy are not solved yet
ANTIBODIES DIRECTED AGAINST INTERLEUKIN-33 (IL-33)

The invention relates to an isolated immunoglobulin heavy chain polypeptide and an isolated immunoglobulin light chain polypeptide that bind to interleukin-33 (IL-33). The invention provides an IL-33-binding agent that comprises the aforementioned immunoglobulin heavy chain polypeptide and immunoglobulin light chain polypeptide. The invention also provides related vectors, compositions, and methods of using the IL-33-binding agent to treat a disorder in a mammal that is responsive to IL-33 inhibition.
« C’est l’État qui nous a tués ! »

À la suite du décès par Ebola d’un parent, une famille accuse l’État guinéen d’être responsable de sa mort. Qu’est-ce qui a conduit à porter une telle accusation? À partir d’une enquête ethnographique en République de Guinée, cet article montre de quelle manière l’histoire politique guinéenne a influencé le déroulement de l’épidémie d’Ebola de 2014 à 2016 dans les pays du fleuve Mano. Pour comprendre comment les crises politiques du passé façonnent le rapport des Guinéens à la crise sanitaire provoquée par Ebola, je procéderai en trois temps. D’abord, je reviendrai sur les violences d’État qui ont jalonné l’histoire politique de la Guinée depuis son indépendance en 1958. Une des conséquences de ces violences se manifeste par un manque de confiance systémique vis-à-vis des élites et des actions gouvernementales. Puis, je montrerai comment les camps d’internement militaires de Sékou Touré réactivent un rapport à l’enfermement induisant des rumeurs et des comportements de peur face aux Centres de traitement d’Ebola (CTE). Enfin, pour me déprendre des approches fondées sur les « réticences » de la population guinéenne aux dispositifs sanitaires de lutte contre l’épidémie, j’analyserai des formes de résistance s’inscrivant plus largement dans l’histoire des contestations politiques en Guinée.
Comparison of near-infrared, mid-infrared, Raman spectroscopy and near-infrared hyperspectral imaging to determine chemical, structural and rheological properties of apple purees

from teaching and research institutions in France or abroad, or from public or private research centers.L'archive ouverte pluridisciplinaire HAL, est destinée au dépôt et à la diffusion de documents scientifiques de niveau recherche, publiés ou non, émanant des établissements d'enseignement et de recherche français ou étrangers, des laboratoires publics ou privés.
Social networks of the past: mapping hispanic and lusophone literary modernity, 1898-1959

Data mining and big data approaches are changing the ways in which we create knowledge, access information and preserve our cultural heritage. This research applies cutting-edge technology to analyse a neglected aspect of European and non-European social and cultural life of the 20th century: the impact of Hispanic and Lusophone literary networks and cultural mediators in international modernity between 1898 and 1959. The project pursues three central goals: 1) to retrieve the lost history of Iberoamerican mediators in modernist intercultural and multilingual networks and reappraise their role; 2) to narrow the knowledge divide in terms of access and production in the Iberoamerican field by generating and making freely available new and reliable data that addresses the lack of documented cultural heritage, and 3) to offer an innovative and reproducible model that can be applied across periods, languages, and disciplines to analyse cross-border phenomena, under-examined mediators and networks and overshadowed geographical scales in their relations to the wider world. These goals will be achieved by a twofold methodology: i) an open and collaborative research tool providing a data source for quantitative and qualitative analysis on Iberoamerican mediators, and ii) four subprojects on key cultural transformation processes distinctive of modern societies (the institutionalization of Iberoamerican cultures, the rise of translated literature in key Iberoamerican modernist journals, the position of Iberoamerican women in the cultural field, and the role of Iberoamerican mediators in new forms of mass media). By combining computational methods, cultural, literary history, translation, sociology, gender and media studies, I will lead an interdisciplinary team of 6 researchers that will fill the gap in modernist studies and will offer an original, reproducible and empirically tested method for studying social human interaction within a global, cultural and decentred approach
Learn to learn human learning process from teleoperated demonstrations

Learning from demonstration (LfD) is a paradigm for enabling robots to autonomously learn from demos to perform new tasks. But, environmental changes, expensive demonstration cost, and potential uncertainties caused by data-based learning make it hard to be applied in actual. The project aims to propose a robot skill learning framework from human learning process via a teleoperation interface to achieve human-like skill learning characteristics such as few-shot learning, learning from failed attempts and tentative actions, and strong skill transfer and generalization ability. Five work packages will be taken to realize the objectives. First, a teleoperated interface will be equipped with multi-sensors and special exoskeleton to minimize information difference between humans and robots. After building a scalable primitive skill (PS) library based on task segmentation with multimodal information, new theories of PS learning and PS-based task graph learning are explored. PS will be learned and generalized based on improved meta-learning that is associated and explained by physical laws and neural motor disciplines. The PS-based task graph will be learned from the human learning process, achieving failure reasoning and adaptation to zero/few-shot tasks. Some practical problems e.g. incomplete data set and difference of sim-to-real applications will also be addressed. Finally, the previous theories will be certified by medical robot tasks. The applicant will acquire a solid state-of-the-art interdisciplinary scientific training in the multidisciplinary research fields, such as artificial intelligence, robotics technologies and mechanical design, and that will enable him to generate new scientific knowledge and quickly develop his research career and leadership. The final aim is to consolidate Europe as the world leader in robot and AI areas and to benefit European robotics applications in industry, surgery, and nuclear waste disposition.
Flexor Tendon Sheath Engineering Using Decellularized Porcine Pericardium

The flexor tendon sheath is an ideal target for tissue engineering because it is difficult to reconstruct by conventional surgical methods. The authors hypothesized that decellularized porcine pericardium can be used as a scaffold for engineering a biologically active tendon sheath.
The authors’ protocol removed cellular material from the pericardium and preserved the structural architecture in addition to the collagen and glycosaminoglycan content. The scaffold was successfully reseeded with human sheath synoviocytes and human adipose-derived stem cells. Cells were evaluated for 8 weeks after reseeding.
The reseeded construct demonstrated continuous production of hyaluronic acid, the main component of synovial fluid. After being seeded on the membrane, adipose-derived stem cells demonstrated down-regulation of collagen I and III and up-regulation of hyaluronan synthase 2.
The results indicate that decellularized porcine pericardium may be a potential scaffold for engineering a biologically active human tendon sheath.
A WASHING MACHINE

The present invention relates to a washing machine (1) comprising a glass (9) that decreases the possibility of laundry getting caught in the bellows (12) by means of its noncircular shape, that provides to increase the volume of the drum (4) and enhance the washing performance by decreasing the depth thereof.
Synthesis of ordered mesoporous MFI zeolite using CMK carbon templates

Abstract Suitability of the ‘dry-gel synthesis method’ has been investigated for the synthesis of ordered mesoporous MFI zeolite using CMK-type mesoporous carbons as a template. Ordered mesoporous carbons with various pore diameters and topologies were infiltrated with a zeolite precursor sol, which was composed of tetrapropylammonium hydroxide, tetraethoxysilane, aluminum isopropoxide and H2O. The porous carbon with the zeolite precursor was heated inside an autoclave under a controlled humidity condition at 443 K. The resultant product indicated that the zeolite precursor migrated onto the external surface of the carbon template to form a bulk zeolite when the relative humidity was excessively high (⩾95%). A highly ordered mesoporous zeolite was synthesized in a carbon template with 10-nm pores when the humidity was lowered to 80–85%. A crystalline zeolite framework was not generated in the case of 2.5-nm pores with rigid walls. When a CMK-3 carbon with 4-nm pores was used as the template, the template walls were destroyed so that the zeolite crystalline domain was several times larger than the diameter of a single pore. Thus, humidity, template pore diameters and framework rigidity should be taken into account for application of the dry-gel synthesis method.
Linking T-cell receptor sequence to functional phenotype at the single-cell level

Although each T lymphocyte expresses a T-cell receptor (TCR) that recognizes cognate antigen and controls T-cell activation, different T cells bearing the same TCR can be functionally distinct. Each TCR is a heterodimer, and both α- and β-chains contribute to determining TCR antigen specificity. Here we present a methodology enabling integration of information about TCR specificity with information about T cell function. This method involves sequencing of TCRα and TCRβ genes, and amplifying functional genes characteristic of different T cell subsets, in single T cells. Because this approach retains information about individual TCRα-TCRβ pairs, TCRs of interest can be expressed and used in functional studies, for antigen discovery, or in therapeutic applications. We apply this approach to study the clonal ancestry and differentiation of T lymphocytes infiltrating a human colorectal carcinoma.
Comparison of four techniques of arthrocentesis of the lateral compartment of the femorotibial joint of the horse

Clinical experiences indicate that centesis of the lateral compartment of the femorotibial joint is often unsuccessful.To determine the accuracy of 2 published and 2 unpublished techniques of centesis of the lateral compartment of the femorotibial joint.It was hypothesised that a drug can be administered into the lateral compartment of the femorotibial joint via a diverticulum of this joint that surrounds the medial aspect of the long digital extensor tendon and that this technique is more accurate than described techniques of centesis of this compartment.Twenty-four stifles of 12 horses were divided equally into 4 groups and a radiocontrast medium injected into the lateral compartment of the femorotibial joint of each group using a hypodermic needle inserted: 1) caudal to the lateral patellar ligament and proximal to the tibial plateau, 2) caudal to the long digital extensor tendon and proximal to the tibial plateau, 3) between the long digital extensor tendon and bone of the extensor groove of the tibia or 4) directly through the long digital extensor tendon until it contacted bone. Twelve veterinary students who had no experience using any of these techniques performed the injections. Accuracy of each technique was determined by examining radiographs obtained after injecting the contrast medium.The most successful technique for arthrocentesis was by inserting a needle through the long digital extensor tendon. This approach was successful in all attempted cases, whilst other techniques had lower rates of success.The lateral compartment of the femorotibial joint can be accessed accurately by inserting a needle through the long digital extensor tendon as it lies within the extensor groove. Other techniques may not be as accurate for clinicians inexperienced in arthrocentesis of the lateral compartment of the femorotibial joint.
East Antarctic rifting triggers uplift of the Gamburtsev Mountains

The Gamburtsev Subglacial Mountains are the least understood tectonic feature on Earth, because they are completely hidden beneath the East Antarctic Ice Sheet. Their high elevation and youthful Alpine topography, combined with their location on the East Antarctic craton, creates a paradox that has puzzled researchers since the mountains were discovered in 1958. The preservation of Alpine topography in the Gamburtsevs may reflect extremely low long-term erosion rates beneath the ice sheet, but the mountains' origin remains problematic. Here we present the first comprehensive view of the crustal architecture and uplift mechanisms for the Gamburtsevs, derived from radar, gravity and magnetic data. The geophysical data define a 2,500-km-long rift system in East Antarctica surrounding the Gamburtsevs, and a thick crustal root beneath the range. We propose that the root formed during the Proterozoic assembly of interior East Antarctica (possibly about 1 Gyr ago), was preserved as in some old orogens and was rejuvenated during much later Permian (roughly 250 Myr ago) and Cretaceous (roughly 100 Myr ago) rifting. Much like East Africa, the interior of East Antarctica is a mosaic of Precambrian provinces affected by rifting processes. Our models show that the combination of rift-flank uplift, root buoyancy and the isostatic response to fluvial and glacial erosion explains the high elevation and relief of the Gamburtsevs. The evolution of the Gamburtsevs demonstrates that rifting and preserved orogenic roots can produce broad regions of high topography in continental interiors without significantly modifying the underlying Precambrian lithosphere.
Large-Eddy Simulation of Atmospheric Boundary-Layer Flow Through a Wind Farm Sited on Topography

Large-eddy simulation (LES) has recently been well validated and applied in the context of wind turbines over flat terrain; however, to date its accuracy has not been tested systematically in the case of turbine-wake flows over topography. Here, we investigate the wake flow in a wind farm situated on hilly terrain using LES for a case where wind-tunnel experimental data are available. To this end, first boundary-layer flow is simulated over a two-dimensional hill in order to characterize the spatial distribution of the mean velocity and the turbulence statistics. A flow simulation is then performed through a wind farm consisting of five horizontal-axis wind turbines sited over the same hill in an aligned layout. The resulting flow characteristics are compared with the former case, i.e., without wind turbines. To assess the validity of the simulations, the results are compared with the wind-tunnel measurements. It is found that LES can reproduce the flow field effectively, and, specifically, the speed-up over the hilltop and the velocity deficit and turbulence intensity enhancement induced by the turbines are well captured by the simulations. Besides, the vertical profiles of the mean velocity and turbulence intensity at different streamwise positions match well those for the experiment. In addition, another numerical experiment is carried out to show how higher (and more realistic) thrust coefficients of the turbines lead to stronger wakes and, at the same time, higher turbulence intensities.
Reconciling qualitative storylines and quantitative descriptions: An iterative approach

Energy system transition research has been experimenting with the integration of qualitative and quantitative analysis due to the increased articulation it provides. Current approaches tend to be heavily biased by qualitative or quantitative methodologies, and more often are aimed toward a single academic discipline. This paper proposes an interdisciplinary methodology for the elaboration of energy system socio-technical scenarios, applied here to the low carbon transition of the UK. An iterative approach was used to produce quantitative descriptions of the UK's energy transition out to 2050, building on qualitative storylines or narratives that had been developed through the formal application of a transition pathways approach. The combination of the qualitative and quantitative analysis in this way subsequently formed the cornerstone of wider interdisciplinary research, helping to harmonise assumptions, and facilitating ‘whole systems’ thinking. The methodology pulls on niche expertise of contributors to map and investigate the governance and technological landscape of a system change. Initial inconsistencies were found between energy supply and demand and addressed, the treatment of gas generation, capacity factors, total installed generating capacity and installation rates of renewables employed. Knowledge gaps relating to the operation of combined heat and power, sources of waste heat and future fuel sources were also investigated. Adopting the methodological approach to integrate qualitative and quantitative analysis resulted in a far more comprehensive elaboration than previously, providing a stronger basis for wider research, and for deducing more robust insights for decision-making. It is asserted that this formal process helps build robust future scenarios not only for socio political storylines but also for the quantification of any qualitative storyline.
Oncogenic receptor network of excellence and training

Cancer is a leading health concern. There is a need to fully understand the fundamental processes underlying development of cancer. There is increasing evidence that G protein-coupled receptors (GPCRs) and their associated signalling cascades are involved in both cancer progression and metastasis. As oncogenic GPCRs are likely to be amenable to manipulation via drugs they are ideal therapeutic targets. In ONCORNET (Oncogenic Receptor Network of Excellence and Training) we propose to target two oncogenic GPCRs; the chemokine receptors CXCR4 and CXCR7. These are highly expressed in a range of tumours and yet their role in cancer progression is not well understood. We will focus on unravelling how CXCR4 and CXCR7 are or can be modulated (small molecules, pepducins, nanodies) and investigate the effects on oncogenic responses. This represents crucial knowledge that we currently do not have and yet may well provide potential leads for drug development and commercialisation. ONCORNET will bring together the leading research scientists and labs in Europe with an interest in GPCRs and 15 early stage researchers. We will employ all the latest multidisciplinary research technologies to understand the role of these GPCRs in cancer and develop CXCR4 and CXCR7 tools for diagnostic and therapeutic purposes. Importantly, developed approaches can be extrapolated to other oncogenic GPCRs. The ONCORNET consortium will offer an extensive multidisciplinary training programme to the ESRs to ensure that they can operate in today’s drug discovery programmes. This will include both research (e.g. drug discovery, proteomics, imaging, modelling) and transferable (e.g. entrepreneurship, writing, media training) skill sets –that is rarely offered at PhD level. We will train ESRs to develop the next generation of multidisciplinary scientists with skills that are highly demanded by many of today’s employers in drug development industries.