SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Development, implementation and evaluation of a dedicated metal artefact reduction method for interventional flat-detector CT

The purpose of this study was to develop, implement and evaluate a dedicated metal artefact reduction (MAR) method for flat-detector CT (FDCT). The algorithm uses the multidimensional raw data space to calculate surrogate attenuation values for the original metal traces in the raw data domain. The metal traces are detected automatically by a three-dimensional, threshold-based segmentation algorithm in an initial reconstructed image volume, based on twofold histogram information for calculating appropriate metal thresholds. These thresholds are combined with constrained morphological operations in the projection domain. A subsequent reconstruction of the modified raw data yields an artefact-reduced image volume that is further processed by a combining procedure that reinserts the missing metal information. For image quality assessment, measurements on semi-anthropomorphic phantoms containing metallic inserts were evaluated in terms of CT value accuracy, image noise and spatial resolution before and after correction. Measurements of the same phantoms without prostheses were used as ground truth for comparison. Cadaver measurements were performed on complex and realistic cases and to determine the influences of our correction method on the tissue surrounding the prostheses. The results showed a significant reduction of metal-induced streak artefacts (CT value differences were reduced to below 22 HU and image noise reduction of up to 200%). The cadaver measurements showed excellent results for imaging areas close to the implant and exceptional artefact suppression in these areas. Furthermore, measurements in the knee and spine regions confirmed the superiority of our method to standard one-dimensional, linear interpolation.
QUANTITATION OF 17 β-ESTRADIOL IN RABBIT PLASMA BY HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY WITH FLUORESCENCE DETECTION

A new method was developed for the determination of 17 β-estradiol in rabbit plasma by reversed-phase high performance liquid chromatography (RP-HPLC) with fluorescence (FL) detection. The method employed one-step extraction of 17 β-estradiol from plasma matrix with a mixture of water and ethylacetate (1.9:5, v/v) using estriol as an internal standard. The mobile phase consisted of a mixture of metanol and water (70:30, v/v) flowing at a flow rate of 1.0 mL min−1. Calibration curve was linear between concentration range of 125–6000 ng mL−1. Average recovery of 17 β-estradiol and the internal standard from the biological matrix was more than 94.9 and 92.5%, respectively. The intra-day and inter-day precision and accuracy were between 3.74–8.12 and 3.72–8.80%, respectively. Also, the method was successfully applied to determine of 17 β-estradiol in New Zealand white rabbits.
METHOD FOR PRE-CALENDERING A BOARD WEB

The invention relates to a method for pre-calendering a board web. The method comprises passing a board web (W) in a pre-calendering process through at least one hard nip (2), which is formed by a metal roll (4) and its counter roll (5), and through at least one long nip (1), which is formed by a thermo roll (6) and a long-nip roll (7) or a long-nip belt assembly. The method comprises moistening the surface of the board web (W) with water prior to passing the same through said at least one hard nip (2).
A prospective european validation cohort for stereotactic therapy of re-entrant tachycardia

Ventricular tachycardia (VT) is an unpredictable and potentially deadly condition and should be promptly treated with catheter ablation and medication, before irreversible and potentially fatal organ damage follows. Unfortunately, this combination of treatments does not prevent VT reoccurrence in 30-50% of VT patients and while they can undergo multiple invasive ablations, technical difficulties or refusal of the patient can lead to a lack of effective treatment options. 

A promising novel, non-invasive treatment option for VT is stereotactic arrhythmia radioablation (STAR). Besides being non-invasive, STAR can also be used to reach locations that are inaccessible for catheter ablation, which may potentially improve effectiveness of overall VT treatment.

Small scale first in men/early phase trials have been performed for STAR, providing proof-of-concept for clinical safety and efficacy. However, patients with recurrent VT are not a homogenous group and each center deals with different inclusion criteria, imaging and/or target definition. Many questions remain and the available studies lack the power to clinically validate the approach and prepare for late stage phase III trials.

The STOPSTORM consortium sets out to consolidate all current and future European efforts to clinically validate STAR treatment by merging all data in a validation cohort study, standardising pre-treatment and follow-up, in order to collect the data sets and statistical power needed to unanimously establish clinical safety, efficacy and benefit for STAR. 

The STOPSTORM consortium also sets out to refine protocols and guidelines, determine volumes of interest, define and model the optimal target region and target dose, also in relation to surrounding healthy tissues (i.e. organs at risk) and determine which patient population and underlying cardiopathies respond best to STAR. By doing so the STOPSTORM consortium paves the way to consensus and future late stage clinical trials for STAR.
[A case of facial nerve palsy induced by nab-paclitaxel].

The patient was a 60-year-old woman who underwent total mastectomy and axillary lymph node dissection for right breast cancer. She was treated with adjuvant chemotherapy( epirubicin plus cyclophosphamide[EC]and paclitaxel), hormone therapy, and radiation therapy. Multiple lung, lymph node, and bone metastases were detected after 4 years. The patient subsequently received nab-paclitaxel (nabPTX, 260 mg/m2, triweekly) and zoledronate therapy. Ptosis of her right eyebrow and the right angle of her mouth were observed after 8 courses of nabPTX, and peripheral right facial nerve palsy was diagnosed. She underwent rehabilitation, and facial nerve palsy improved after 9 months. Peripheral facial nerve palsy is a very rare adverse event of nabPTX. This is the first case report of peripheral facial nerve paralysis associated with nab- PTX.
METHOD AND DEVICE FOR PRODUCING A COMPONENT

The invention relates to a method for producing a component (11), in particular a component (11) of a turbine or a compressor, wherein at least the steps of applying, in layers, at least one powder component material (14) to a component platform (16) in the area of a buildup and joining zone (20), locally fusing and/or sintering, by layer, the component material (14) by applying energy by means of at least one electron beam (22) in the area of the buildup and joining zone (20), lowering, by layer, the component platform (16) by a predefined layer thickness, and repeating the steps a) through c) until the component (11) is complete, are performed. During production, electrons (e) emitted by the interaction of the electron beams (22) and the component material (14) are captured, after which material information characterizing a topography of the fused and/or sintered component material is derived using the emitted electrons (e). Alternatively or additionally, the component material is fused and/or sintered by at least two, preferably by at least four electron beams. The invention further relates to devices (10) for producing a component (11).
Coastal Governance and Adaptation Policies in the Mediterranean

COASTGAP springs after more than 10 years of shared experiences among many Mediterranean coastal Administrations and Institutions in the field of coastal adaptation to CC effects and other natural/anthropogenic threats. In 2011 these actors established the cluster FACECOAST (www.facecoast.eu) and propose COASTGAP in order to capitalize 12 Best Practices from 9 projects of the cluster (from MED and other programmes). The BPs concern several aspects of ICZM, Flood Directive, Maritime Spatial Planning and other relevant legal provisions. Some of them deal with the general matter of governance: they foster the political initiative (Bologna Charter 2012) or the rational use of the coastal resources (SICELL), widen the suitable application of provisions, regulations and laws like ICZM Protocol (art.8) or Flood Directive (COFLERMAP), specify environmental procedures for the coastal safeguard (EIA & SEA) and other topics having a great impact on coastal zones management. WP3 will concern specifically the capitalization process of these BPs throughout their diffusion among other actors (inside and outside the partnership), their adaptation to different situations and their mainstreaming in local, regional and national framework. COASTGAP aims as well to design, characterize and prepare to launch the Macro-Project -BEACHMED-3-�, already sketched in previous projects (MEDGOV, COASTANCE, MAREMED). WP 4 is dedicated to the Macro-project and it will concern a coordinated set of concrete proposals (projects, researches, network, etc.) in order to face focal questions like quantitative coastal hazard assessment (EUROSION-MED), the characterization of coastal territory and its sustainable development, coastal sediments and their individuation and sustainable use for adaptation policies, the shared monitoring of coastal areas exposed to CC effects through a network of observatories (EURIOMCODE), etc.
Lithography information control system

A lithography system comprises an information gathering apparatus for gathering specific information set in each of plural exposure apparatus and variable according to operating conditions of each of the plural exposure apparatus in response to masks to be used in each of the plural exposure apparatus and substrates supplied thereto, or information obtained by measuring or evaluating the process state of a substrate processed by each of the plural exposure apparatus, independently from the control by a process control apparatus for controlling supply of the masks, supply of plural substrates to be exposed in each of the plural exposure apparatus, and operating conditions of each of the plural exposure apparatus in response to the masks and substrates supplied thereto. The lithography system further comprises a system observer apparatus capable of modifying or correcting a part of working paremeters set in each of the exposure apparatus, based on the gathered information, in such a manner that the operating conditions set by the process control apparatus can be stably maintained, independently from the control of the process control apparatus.
HEARING AID ADAPTING DEVICE

Hearing perceptions are inputted (5) into an adaptation calculator (3) that calculates the changes to be made in the parameters ( alpha x) of the hearing aid transmission function and transmits them to the hearing aid (7). The calculator (3) determines which audio test signal (T) is to be pressed on to the person using the hearing aid. To this end, the hearing aid adapting device comprises the above-mentioned calculator (3) and an audio storage medium-playback unit (9). The calculator (3) controls (E9) which audio test signal is to be played back.
Research empowerment on solute carriers (resolute)

The Research empowerment on solute carriers (ReSOLUTE) proposal aims at inducing a decisive acceleration in the
intensity of SLC research worldwide while establishing solute carriers (SLCs) as a tractable target class. It is composed of a
core consortium of seven academic/SME members (CeMM, Univ. of Oxford, Univ. of Manchester, AXXAM Spa, Univ. Leiden, Max-Planck Institut für medizinische Forschung, Univ. Wien) and six industrial partners (Pfizer Limited UK, Novartis Pharma AG, Boehringer-Ingelheim, Vifor Pharma Group, Sanofi Aventis Recherche et Développement, Bayer AG) with established and complementary expertise combining industry grade standards and systems level principle-driven analysis.

ReSOLUTE merges systematic and focused approaches: 1) the generation of reliable and validated ‘hardware’ such as cell lines, proteins, antibodies/high affinity binders and large ‘omics’ datasets, 2) a central deorphanisation process coupling genomic engineering to metabolomics and supported by genetic and proteomics studies, 3) a non-redundant process to test systematically the suitability of a certain SLC to a variety of assay formats, 4) a collection of interlinked networks that cover different expertise, datasets and functional connections among SLCs, integrated into large-scale data repositories and a dedicated knowledgebase. The ReSOLUTE strategy will be applied in parallel at the super-family level and, in a more in-depth manner, to a prioritized gene list elected to be potential drug targets. To implement this and achieve the expected goals, the consortium is supported by a large network of academic and industrial partners with specific knowledge of certain SLCs and tools, willing to be accessed at any time and provide specific expertise. Together with a strong dissemination and exploitation plan, we therefore expect that ReSOLUTE will transform the landscape of SLC research for years to come.
Parametric resonance of truncated conical shells rotating at periodically varying angular speed

Abstract Parametric resonance of a truncated conical shell rotating at periodically varying angular speed is studied in this paper. Based upon the Love׳s thin shell theory and generalized differential quadrature (GDQ) method, the equations of motion of a rotating conical shell are derived. The time-dependent rotating speed is assumed to be a small and sinusoidal perturbation superimposed upon a constant speed. Considering the periodically rotating speed, the conical shell system is a parametric excited system of the Mathieu–Hill type. The improved Hill׳s method is utilized for parametric instability analysis. Both the primary and combination instability regions for various natural modes and boundary conditions are obtained numerically. The effects of relative amplitude and constant part of periodically rotating speed and cone angle on the instability regions are discussed in detail. It is shown that for the natural mode with lower circumferential wavenumber, only the primary instability regions exist. With the increasing circumferential wavenumber, the instability widths are reduced significantly and the combination instability region might appear. The results for different boundary conditions are substantially similar. Increasing the constant rotating speed (or cone angle) all lead to the movements of instability regions and the appearance of combination instability region. The former will cause the instability width increasing, while the latter will reduce the instability width. The variation of length-to-radius ratio only causes the movements of instability regions.
Forest expansion dominates China’s land carbon sink since 1980

Abstract Carbon budget accounting relies heavily on Food and Agriculture Organization land-use data reported by governments. Here we develop a new land-use and cover-change database for China, finding that differing historical survey methods biased China’s reported data causing large errors in Food and Agriculture Organization databases. Land ecosystem model simulations driven with the new data reveal a strong carbon sink of 8.9 ± 0.8 Pg carbon from 1980 to 2019 in China, which was not captured in Food and Agriculture Organization data-based estimations due to biased land-use and cover-change signals. The land-use and cover-change in China, characterized by a rapid forest expansion from 1980 to 2019, contributed to nearly 44% of the national terrestrial carbon sink. In contrast, climate changes (22.3%), increasing nitrogen deposition (12.9%), and rising carbon dioxide (8.1%) are less important contributors. This indicates that previous studies have greatly underestimated the impact of land-use and cover-change on the terrestrial carbon balance of China. This study underlines the importance of reliable land-use and cover-change databases in global carbon budget accounting.
Testing Propositions Derived from Twitter Studies: Generalization and Replication in Computational Social Science

Replication is an essential requirement for scientific discovery. The current study aims to generalize and replicate 10 propositions made in previous Twitter studies using a representative dataset. Our findings suggest 6 out of 10 propositions could not be replicated due to the variations of data collection, analytic strategies employed, and inconsistent measurements. The study's contributions are twofold: First, it systematically summarized and assessed some important claims in the field, which can inform future studies. Second, it proposed a feasible approach to generating a random sample of Twitter users and its associated ego networks, which might serve as a solution for answering social-scientific questions at the individual level without accessing the complete data archive.
Positive Feedback Regulation between Phospholipase D and Wnt Signaling Promotes Wnt-Driven Anchorage-Independent Growth of Colorectal Cancer Cells

Aberrant activation of the canonical Wnt/beta-catenin pathway occurs in almost all colorectal cancers and contributes to their growth, invasion and survival. Phopholipase D (PLD) has been implicated in progression of colorectal carcinoma However, an understanding of the targets and regulation of this important pathway remains incomplete and besides, relationship between Wnt signaling and PLD is not known.Here, we demonstrate that PLD isozymes, PLD1 and PLD2 are direct targets and positive feedback regulators of the Wnt/beta-catenin signaling. Wnt3a and Wnt mimetics significantly enhanced the expression of PLDs at a transcriptional level in HCT116 colorectal cancer cells, whereas silencing of beta-catenin gene expression or utilization of a dominant negative form of T cell factor-4 (TCF-4) inhibited expression of PLDs. Moreover, both PLD1 and PLD2 were highly induced in colon, liver and stomach tissues of mice after injection of LiCl, a Wnt mimetic. Wnt3a stimulated formation of the beta-catenin/TCF complexes to two functional TCF-4-binding elements within the PLD2 promoter as assessed by chromatin immunoprecipitation assay. Suppressing PLD using gene silencing or selective inhibitor blocked the ability of beta-catenin to transcriptionally activate PLD and other Wnt target genes by preventing formation of the beta-catenin/TCF-4 complex, whereas tactics to elevate intracellular levels of phosphatidic acid, the product of PLD activity, enhanced these effects. Here we show that PLD is necessary for Wnt3a-driven invasion and anchorage-independent growth of colon cancer cells.PLD isozyme acts as a novel transcriptional target and positive feedback regulator of Wnt signaling, and then promotes Wnt-driven anchorage-independent growth of colorectal cancer cells. We propose that therapeutic interventions targeting PLD may confer a clinical benefit in Wnt/beta-catenin-driven malignancies.
Radio device and fault position specifying method

A radio device includes a radio unit to perform modulation processing on a signal, an antenna to transmit and receive signals to and from an external unit, a cable to connect the radio unit to the antenna, a reflection time calculation unit to calculate a reflection time taken from after the transmission signal is input into a prescribed part of the radio unit until a transmission signal which is output from the radio unit is reflected on a path from the cable to the antenna is fed back to the prescribed part of the radio device, and a fault position specifying unit to specify a position candidate at which a fault occurs on the cable based on the calculated reflection time when the calculated reflection time is less than a reflection time threshold value.
ManuFactUring educaTion and training governance model for IndUstry 4.0 in the Adriatic-Ionian aREa PLUS

The Naval Industry, Shipbuilding and the related supply chain in Adriatic-Ionian region are facing great challenges, looking toward the significant transformation of manufacturing industry, the Fourth Industrial Revolution, that involves the entire value chain process with effects on production, intercompany relations and human capital development and requires a new technology brush-ups.

The FUTURE 

4.0 project developed an experimental methodology of knowledge transfer addressed to the companies operating in the sector, with the aim to support their transition toward Industry 

4.0 and break barriers to innovation between university, center of research and enterprises.

Tools and models were designed and tested to strengthen competences, raise the awareness on technology needs and trends, and rethink the set of skills and abilities enabling the industrial transformation. Now it is time to effectively share them and contribute in this way to the competitiveness of the shipbuilding and logistics sectors and to their resilience in dealing with the consequences of the COVID-19 pandemic.

In order to maximize the visibility of the project achievements, the new FUTURE 

4.0 PLUS will implement actions for the valorization of the knowledge capital produced, making it widely available, particularly for companies and training institutions that are approaching the transition to a more green and digital dimension.

Looking towards the Factory of the Future concept, targeted workshops and events will be organized to address the issue of Industry 

4.0 transformation from different perspectives, sharing research results, introducing further applications of learning tools, and reinforcing the Network established between academic and enterprises active in the Adriatic – Ionian region.

New communication content such as tutorial videos will be designed to illustrate the main aspects of the FUTURE 

4.0 project and the practical and effective application of its knowledge transfer methodology. In addition, the relevant contents relating to the Technological Map developed will be highlighted. The most inspiring contributions and experiences emerged from the implementation of the Pilot Actions will be shared in a dedicated web area, where also the project analysis and researches, duly reviewed, will be at disposal for consultation.