SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Émergence et expansion de la résistance à la pipéraquine sur le plateau des Guyanes

La Dihydroartémisinine-Pipéraquine (DHA-PI) est une association à base de dérivés de l'artémisinine utilisée pour traiter le paludisme à Plasmodium falciparum (Pf). Son utilisation, en Asie du Sud-Est, a entraîné l'émergence de souches résistantes à la fois à l'artémisinine et à la pipéraquine (PI). La résistance à PI y était caractérisée par la présence d'amplification du nombre de copie des gènes plasmepsines 2 et 3 (Pfpm2/3) et par l'émergence de mutations dans le transporteur PfCRT (Chloroquine Resistance Transporter). Sur le plateau des Guyanes, l'automédication des orpailleurs par des associations comprenant la PI, interroge sur la possible sélection de parasites résistants à cette molécule dans la région Des isolats de Pf, collectés entre 1997 et 2018 dans les pays du plateau des Guyanes (Guyane, Brésil, Suriname, Guyana, Venezuela et Colombie), ont été génotypés en position 350 de PfCRT par séquençage et le nombre de copie de Pfpm2/3 a été évalué par PCR quantitative. Des cas d'échec thérapeutique (4/7), rapportés entre 2016 et 2018 en Guyane, ont été caractérisés. Les tests phénotypiques réalisés sur des isolats collectés entre 2008 et 2018 ont, identifiés 45,3 % (95 % CI : 34,8 % - 55,9 % ; 39/86) d'isolats résistants à la PI. Ceux-ci étant majoritairement associés (p<0,001) aux 2 marqueurs de résistance précédemment cités. Ces marqueurs sont également très présents au Suriname (82,1 %, soit 23/28 entre 2012 et 2013) et au Guyana (68,2 %, soit 73/107 entre 2014 et 2017), alors que leur prévalence est négligeable voire inexistante au sein de la population parasitaire testée au Brésil (3,1 %, soit 1/32 entre 2009 et 2014) et au Venezuela (0,0 %, soit 0/23 entre 2017 et 2018). L'étude génotypique longitudinale réalisée en Guyane entre 1997 et 2018, a mis en évidence l'émergence séquentielle de la mutation PfCRTC350R d'une part, puis des amplifications de Pfpm2/3, à partir de 2002. Parallèlement, l'étude des cas d'échec thérapeutique sous traitement à DHA-PI, a mis en lumière l'implication des deux marqueurs de résistance à la PI. Ces données suggèrent que les parasites mono-résistants à la PI induisent des échecs thérapeutiques. Cette étude a permis la caractérisation de deux des marqueurs de résistance à la PI en Amérique du Sud, à savoir la mutation PfCRTC350R et l'amplification du nombre de copie des gènes Pfpm2/3. Ces marqueurs sont associés à des cas d'échec thérapeutique sous traitement DHA-PI en Guyane. La forte prévalence de ces marqueurs nous incite à recommander l'arrêt de l'utilisation de la pipéraquine dans la région Aucun lien d'intérêt
(6439.12122014.079000111) VIGOR – UNTERSTÜTZUNG DES ORGANISATORISCHEN WANDELS UND DER INNOVATION DES ANGEBOTS FÜR DIE NIVI-GRUPPE

VOR DEM HINTERGRUND DER OBIGEN ABSCHNITTE IN BEZUG AUF DEN GESCHÄFTS- UND MARKTKONTEXT HAT SICH DIE NIVI-GRUPPE ENTSCHIEDEN, DIE BERATUNGSUNTERSTÜTZUNG IN ANSPRUCH ZU NEHMEN, DIE ES IHR ERMÖGLICHT, SICH MIT EINER ORGANISATIONSSTRUKTUR UND STEUERUNGSINSTRUMENTEN FÜR DAS UNTERNEHMEN MEHR AUSZUSTATTEN? EFFIZIENT UND ERMÖGLICHEN ES IHNEN, DEN ANDEREN MITBEWERBERN DIE CHANCEN VOLL UND GANZ VORAUS ZU SEIN? IM ZUSAMMENHANG MIT DER ZUNAHME DES EINSATZES VON PARKMANAGEMENTSYSTEMEN EVOLUTI.THE HAUPTZIEL DES VIGOR-PROJEKTS? DASS DAS BEGÜNSTIGTE UNTERNEHMEN MIT FORTSCHRITTLICHEN UND WIRKSAMEN MANAGEMENTINSTRUMENTEN FÜR DIE VERWALTUNG SEINES GESCHÄFTS MIT POSITIVEN AUSWIRKUNGEN AUF DAS POTENZIAL AUSGESTATTET WIRD? DEN WERT ZUM NUTZEN ALLER ZIELE VON STAKEHOLDERS.TALE ZU ERHÖHEN, INSBESONDERE IN BEZUG AUF QUALITÄT? UND DIE AUSWIRKUNGEN DER EINGEFÜHRTEN INNOVATIONEN, ODER? ENTWEDER MIT HILFE EINES EXTERNEN LIEFERANTEN, DES UNTERNEHMENS, VERFOLGT? PRAGMA S.R.L., MIT FACHKOMPETENZ UND PAR.
Stimuli-Responsive two-dimensional materials for renewable energy

I will engineer van der Waals (vdW) heterostructures of two-dimensional (2D) materials with tuneable electrochemical response for exploitation in renewable energy applications. These heterostructures, which are constructed by stacking 2D crystals on top of each other, have been attracting increasing attention in solid-state physics, optoelectronics, and photonics but their full potential in electrochemical applications such as energy storage, conversion, and sensing remains completely unexploited. I will control their electrochemical response by external stimuli including electric field, strain, and illumination. In order to succeed, I will first develop a solid understanding of the unexplored key electrochemical properties of 2D materials and their dependence on these stimuli. I will fully exploit my recent experience in 2D materials’ research and the access to the world-class nanofabrication and characterisation facilities and scientific expertise at Cornell University, the University of Manchester, and National Physical Laboratory.

This research is motivated by the ever-increasing need for reliable sources of renewable energy, which will provide clean and inexpensive electric energy and address the irreversible depletion of fossil fuels. However, the intermittent nature of renewables (day-night, tidal, and weather cycles) does not permit on-demand supply of electricity. Energy conversion and storage technologies, whose majority relies on electrochemical interfaces, balance this ‘demand vs. supply’ mismatch and prevent energy wastage. The topic of my fellowship is in an excellent alignment with the long-term research strategies within the Horizon 2020 and Graphene Flagship EU programmes. The proposed research will have a significant impact on target areas of EU energy policy, i.e. the 2030 Energy Strategy and Horizon 2020 research programme: namely the 27% of energy consumption from renewable sources and 27% of energy savings while meeting the current demands.
¿Cuáles son las experiencias de discriminación de las personas migrantes en Tenerife?

El Observatorio de la Inmigración de Tenerife ha llevado a cabo un estudio que evidencia que la discriminación es una experiencia común para muchas personas migrantes residentes en Tenerife. Las experiencias de discriminación varían según el continente de origen, siendo la población de origen africano la que expresa mayores niveles de discriminación. Otras variables importantes, que correlacionan con el origen, son la raza, la religión y la clase social: la población que se identifica como árabe o negra/afro, la población musulmana y las personas de clase baja, son las que manifiestan sufrir discriminación con mayor frecuencia
Prediksion: an evolutionary guided and experimentally validated computational pipeline to unravel new polyketide synthase functionality

Many of the most valuable, yet complex chemicals in society are obtained from bacteria, who use giant, multimodular acyltransferase polyketide synthase (AT PKS) enzyme complexes to make these products. The modular nature of these enzymes holds the promise to engineer biosynthetic assembly lines to produce new, societally relevant products in a benign and sustainable manner. However, the chemical functionalities installed by the textbook cis-AT PKSs is mostly limited to several basic moieties.

In contrast, in a second class of PKSs, trans-AT PKSs, over 150 different module types have been identified, yet with many more still uncharacterized. Initial results show that bioinformatically-guided approaches can be effective ways to assign the functionality of these uncharacterized modules, but only individual examples have been studied. To catalyze the discovery of new functionality in trans-AT PKSs, I propose PrediKSion: a comprehensive, evolution-guided and experimentally validated computational pipeline to unravel the hidden chemical functionality of unassigned trans-AT PKS modules.

PrediKSion will facilitate unbiased discovery of new module functionalities by looking at the phylogeny of ketosynthases (KSs) in the PKS sequences. The high substrate selectivity in KSs reveals crucial  information on chemistry installed by upstream modules and can thereby lead to the discovery of new and unexpected biosynthetic features in uncharacterized PKS modules and elusive trans-acting components. PrediKSion will be applied on the complete bacterial tree of life and achieve great impact by providing the community with a global mapping of predicted chemical functionality in trans-AT PKSs. The computational suggestions will finally be validated experimentally and the substrate scope of new PKS modules will be studied. In this way, PrediKSion will accelerate the mapping of uncharacterized PKSs and the discovery of new metabolites and potentially interesting pharmaceutical platforms.
Microscopy Image Browser: A Platform for Segmentation and Analysis of Multidimensional Datasets

Understanding the structure-function relationship of cells and organelles in their natural context requires multidimensional imaging. As techniques for multimodal 3-D imaging have become more accessible, effective processing, visualization, and analysis of large datasets are posing a bottleneck for the workflow. Here, we present a new software package for high-performance segmentation and image processing of multidimensional datasets that improves and facilitates the full utilization and quantitative analysis of acquired data, which is freely available from a dedicated website. The open-source environment enables modification and insertion of new plug-ins to customize the program for specific needs. We provide practical examples of program features used for processing, segmentation and analysis of light and electron microscopy datasets, and detailed tutorials to enable users to rapidly and thoroughly learn how to use the program.
An Abstraction-Refinement Framework for Trigger Querying

Abstract Trigger querying is the problem of finding, given a system M and an LTL formula ϕ, the set of scenarios that trigger ϕ in M; that is, the language L of finite computations of M such that all infinite computations that have a prefix in L continue with a suffix that satisfies ϕ. For example, the trigger query M ⊧ ? ↦Ferr asks for the set of scenarios after which err aught to eventually happen. Trigger querying thus significantly extends query checking, which seeks propositional solutions, and is an extremely useful methodology for system exploration and understanding. The weakness of trigger querying lies in the fact that the size of the solution is linear in the size of the system. For trigger querying to become feasible in practice, we must offer solutions to cope with systems of big, and possibly infinite, state spaces.In this paper we describe an abstraction-refinement framework for trigger querying. The general idea is to replace the reasoning about M by reasoning about an abstraction M A of M, and return to the user two languages, L l and L u , that under- and over-approximate L, respectively. We consider predicate abstraction, and the languages L l and L u are defined with respect to the set of predicates. The challenge in defining the approximating languages is that trigger querying does not have a clear polarity, and the definition of L l and L u has to combine the upper- and over-approximations of M. We describe an automata-theoretic approach for refining and reducing L u ∖ L l . While refinement for model checking is lengthwise, in the sense that it is based on counterexamples, here we suggest both lengthwise and widthwise refinement, where the latter is based on cuts in an automaton for L u ∖ L l and thus can symbolically handle batches of counterexamples. We show that our framework is robust and can be applied also for classical query checking as well as variants and extensions of trigger querying.KeywordsModel CheckAbstract StateRegular ExpressionAtomic PropositionKripke StructureThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
Hidrogels reticulados bioinspirados como enchimentos dérmicos. 1. Ano de Investigação Fase 1

Devem ser desenvolvidos enchimentos dérmicos biocompatíveis, que se baseiam na ligação cruzada do ácido hialurónico biopolímero natural pelo princípio natural da ligação de dissulfeto.
Selective solution pool pruning in multi-agent optimization systems for the transit route network design problem

Agent optimization systems have been used to find near optimal results for many intractable problems, including the Traveling Salesman problem and the Transit Route Network Design (TRND) problem. In the agent architectures used for these problems, agents collaborate by working with a common pool of solutions, creating, modifying, or destroying solutions in this pool. It has been posited that “adept destruction can compensate for inept construction” in these optimization systems [1]. This paper proposes a Selective Solution Pool Pruning agent that manages the diversification and intensification of the agent search process. This agent is instantiated for a system that is designed to optimize the TRND problem for a de facto benchmark transit network. The optimization system results show the Selective Solution Pool Pruning agent provides an effective means for managing the search process.
Energetics of Polar and Nonpolar Facets of PbSe Nanocrystals from Theory and Experiment

Surface energies of the distinct facets of nanocrystals are an important factor in the free energy and hence determine the nanocrystal morphology, chemical and physical properties, and even interparticle dipole interactions. Here we investigate the stability and atomic structure of polar and nonpolar PbSe surfaces by combining first-principles calculations with high-resolution transmission electron microscopy (TEM). For uncapped surfaces, the calculations predict that the nonpolar {100} surface is the most stable with a surface energy of 0.184 J m(-2), while the nonpolar {110} and reconstructed {111}-Pb surfaces have surface energies of 0.318 J m(-2) and 0.328 J m(-2), respectively. Fully polar {111} surfaces are structurally unstable upon relaxation. These findings are in good agreement with TEM observations showing that capped nanocrystals have a nearly spherical, multifaceted morphology, while cubical shapes with predominantly {100} facets are obtained when the capping molecules are removed through heating in vacuum. During this process, however, also multipolar surfaces can temporarily exist just after the removal of the surfactants. These metastable {111} surfaces consist of ribbon-like nanodomains, whereby the ribbons are alternating in polarity. The calculations confirm that these multipolar surfaces are energetically more favorable than fully polar surfaces. The consequences for capped nanocrystals (a dominant Pb-oleate termination) and nanocrystal fusion (a shorter interaction range of dipole interactions) are discussed.
APPARATUS AND METHOD FOR AUTHENTICATING A USER VIA MULTIPLE USER DEVICES

﻿A method includes forming, during access to a site, an association between a user and a first device. Contact information for a second device associated with the user is obtained. During a subsequent access to the site the first device is recognized. The user is prompted to authenticate without inputting identifying information. The user is authenticated at the site relying upon the association and a positively acknowledged message from the second device.
Structural and Cohersion Funds: Theoretical and Statistical Aspects in Romania and EU

The paper approaches structural and cohesion funds for the financial perspective 2007-2013. The article describes briefly the evolution of regional development policy, the financial allocations, the impact of EU funds within cohesion policy, legal and institutional framework in Romania, and the institutions which are responsible for the management of EU funds. In Romania, the absorption of structural and cohesion funds is still a problem due to high rejection rate and the existing problems in procuring their own funds by the beneficiaries, such as beneficiary’s contribution, starting the project and covering the non-eligible expenditures. Romanian authorities should increase the absorption rate on transport sector and other sectors where absorption is a problem. Access to Social and Cohesion Funds represents for Romania an opportunity to develop balanced regions, to modernize transportation and environmental infrastructure to support rural development, employment opportunities for labor market, and to promote social policies to increase living standards. Romania has to consider “Life Long Learning” as a priority in the development of the human resources. Less bureaucracy is necessary for a normal development of procedures for refund claims. Also, it is necessary to shorten the time for reimbursement and to simplify related procedures. By increasing the amounts reimbursed, the authorities would increase the possibility to use EU funds more quickly. Preventive control can eliminate situations of default of non-eligible expenditure.
Uptake and cellular distribution of nucleolar targeting peptides (NrTPs) in different cell types

Nucleolar targeting peptides (NrTPs) are a family of cell penetrating peptides (CPPs) derived from crotamine, a rattlesnake venom toxin. They were named NrTPs for their remarkable nucleolus-homing properties and have been studied for their potential as drug delivery vehicles. Live cell microscopy experiments were conducted to monitor NrTP uptake and distribution in different cell types, including primary cells (PBMCs and erythrocytes) and different immortalized cell lines (HeLa, BHK21, BV-173, and MOLT-4). Uptake dependence on cell type (primary vs. immortalized, suspension vs. adherent, cancer vs. healthy cells), peptide concentration and cell viability were evaluated. To gain further insight on the internalization mechanism, uptake kinetics was also monitored. Results showed the uptake and distribution pattern as strongly dependent on peptide sequence, peptide concentration and membrane constituents. Under similar conditions, NrTP6 is more internalized than NrTP1, NrTP2 and NrTP5. Additionally, while internalization of NrTP7 and NrTP8 may cause cytotoxicity, NrTP6 is noncytotoxic. Higher peptide concentrations can be correlated to nucleolar targeting, although even at low concentrations a residual number of cells reveal positive nucleolar labeling. NrTPs were successfully internalized into all cell types tested except erythrocytes.
AGRICULTURALLY BENEFICIAL MICROBES, MICROBIAL COMPOSITIONS, AND CONSORTIA

The disclosure relates to isolated microorganisms—including novel strains of the microorganisms, microbial consortia, and agricultural compositions comprising the same. Furthermore, the disclosure teaches methods of utilizing the described microorganisms, microbial consortia, and agricultural compositions comprising the same, in methods for imparting beneficial properties to target plant species. In particular aspects, the disclosure provides methods of increasing desirable plant traits in agronomically important crop species.
DERE: A Task and Domain-Independent Slot Filling Framework for Declarative Relation Extraction

Most machine learning systems for natural language processing are tailored to specific tasks. As a result, comparability of models across tasks is missing and their applicability to new tasks is limited. This affects end users without machine learning experience as well as model developers. To address these limitations, we present DERE, a novel framework for declarative specification and compilation of template-based information extraction. It uses a generic specification language for the task and for data annotations in terms of spans and frames. This formalism enables the representation of a large variety of natural language processing challenges. The backend can be instantiated by different models, following different paradigms. The clear separation of frame specification and model backend will ease the implementation of new models and the evaluation of different models across different tasks. Furthermore, it simplifies transfer learning, joint learning across tasks and/or domains as well as the assessment of model generalizability. DERE is available as open-source software.
Unmixing Acoustic Sources in Real Reverberant Environments for Close-Microphone Applications*

The problem of acoustic source separation is addressed in an audio application context, especially when considering close-microphone applications and the effects of room acoustics. The framework of blind source separation (BSS) is used here to formally describe the problem, and solutions derived from this framework are examined for the case of separating two interfering acoustic sources in various realistic rooms and conditions. Specifically the performance of a benchmark convolutive BSS algorithm and a Wiener filter, considered in this context as a special case of BSS algorithm, is compared via objective measures as well as a subjective evaluation test to assess their performance. The Wiener filter was found to achieve superior performance and proved to be a simple, efficient method to separate two audio sources in such applications.
“Commercialisation of R & D results and implementation of round coniferous wood processing technology using cross abrasion and thermal modification process.”

The project in question constitutes an investment in tangible and intangible assets related to the retrofitting of the technological facilities of the Applicant’s plant enabling the diversification of the product offer by introducing a new eco-innovative product (product group) to the target, domestic and foreign market, at least on a national scale, manufactured on the basis of the technology developed in the R & D works, i.e.: Non-core or open cross abrasion, also thermally modified, with higher quality and strength parameters, extended durability in conditions of internal and external use and increased resistance to destructive factors, e.g. biotic, fire or atmospheric factors, having important features for end users giving a competitive advantage. The project includes the purchase of the latest generation of machines and production equipment as well as a specialised electronic control system for the sorting and control of logs, for the implementation of the R & D technology of round conifer treatment and the production of commercial lumber devoid of core using optical detection, cross abrasion and thermal modification process, as well as implementation of the Environmental Management System ISO 14001 and eco-innovative marketing principles. The implementation of the project will contribute to improving the competitiveness and innovation of the region based on the Smart Specialisations of the Podlaskie Voivodeship indicated as the core of specialisation, i.e. 1.4 Eco-innovation, environmental sciences and value chain sectors, including: sustainable logging and processing of timber and other raw materials, as well as for the development of the company, modernising both its functioning and equipment. The investment measures taken will make it easier for the Applicant to compete effectively on the domestic market and on foreign markets.