SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Analysis and optimization of the system-level simulator

Simulator is a software system running on the host and the behaviour of the simulated target architecture machine. It can explain and execute the executable program on the target architecture machine, while providing run-time instruction and event-related records, as well as the performance of statistical parameters of the target architecture machine. Systemlevel architecture simulator can be used as a virtual target machine running the software system can achieve the functional simulation of the single (multi) processor, system memory, cache, and an external device subsystem. The simulator is an important means for the processor architecture. Accurate simulation of the processor architecture can access and analyze the architecture parameters on the performance of the processor, to provide effective support for the architecture design space exploration. Simulator development purposes and a different focus, vary widely in speed, uses simulation target, degree of simulation. This article is based on the characteristics of different workloads to study the performance of several state-of-art system-level architecture simulators and focuses on the method that can improve the system performance significantly. We take SPLASH-2 as the benchmark to test the performance of these representative system-level architecture simulators. Finally we give a summary on the optimization methods of different kinds of simulators.
Marketing and politics: Models, behavior, and policy implications

The American presidential election is one of the largest, most expensive, and most comprehensive marketing efforts. Despite this fact, marketing scholars have largely ignored this campaign, as well as thousands of others for congresspersons, senators, and governors. This article describes the growth of interest in research issues related to political marketing. This emerging research area lies at the crossroads of marketing and political science, but these fields have developed largely independent of one another with little cross-fertilization of ideas. We discuss recent theoretical, empirical, and behavioral work on political campaigns, integrating perspectives from marketing and political science. Our focus is on (1) the extent to which paradigms used in goods and services marketing carry over to the institutional setting of political campaigns, (2) what changes are necessary in models and methodology to understand issues in political marketing and voter behavior, and (3) how the special setting of politics may help us gain a better understanding of certain topics central to marketing such as advertising, branding, and social networks.
Torsion and Bending Properties of Shape Memory and Superelastic Nickel-Titanium Rotary Instruments

Recently introduced into the market are shape memory nickel-titanium (NiTi) rotary files. The objective of this study was to investigate the torsion and bending properties of shape memory files (CM Wire, HyFlex CM, and Phoenix Flex) and compare them with conventional (ProFile ISO and K3) and M-Wire (GT Series X and ProFile Vortex) NiTi files.Sizes 20, 30, and 40 (n = 12/size/taper) of 0.02 taper CM Wire, Phoenix Flex, K3, and ProFile ISO and 0.04 taper HyFlex CM, ProFile ISO, GT Series X, and Vortex were tested in torsion and bending per ISO 3630-1 guidelines by using a torsiometer. All data were statistically analyzed by analysis of variance and the Tukey-Kramer test (P = .05) to determine any significant differences between the files.Significant interactions were present among factors of size and file. Variability in maximum torque values was noted among the shape memory files brands, sometimes exhibiting the greatest or least torque depending on brand, size, and taper. In general, the shape memory files showed a high angle of rotation before fracture but were not statistically different from some of the other files. However, the shape memory files were more flexible, as evidenced by significantly lower bending moments (P < .008).Shape memory files show greater flexibility compared with several other NiTi rotary file brands.
Characterization of the Interactions of the Bacterial Cell Division Regulator MinE

III Acknowledgements IV List of Abbreviations VII List of Figures VIII List of Tables X Chapter 1: Introduction 1 1.1: Bacterial Cell Division 1 1.2: Min Protein Interactions 2 1.3: MinD Structure and Interactions with MinE 5 1.4: MinE Residues Required for MinD Binding 9 1.5: Topological Specificity Function in MinE 11 1.6: A Surprising Structure For Full-length MinE 13 1.7: MinE Interaction with Lipids 16 1.8: Thesis Objectives 17 1.9: Neisseria gonorrhoeae versus Escherichia coli Min Proteins 19 1.10: Kinetics of MinE-Stimulated MinD Activity 21 1.11: CD Spectroscopy to Characterize Structural Changes in MinE 22 1.12: Basic Principles of NMR Spectroscopy 24 1.13: Screening of Lipid-Mimetic Environments by the 15 N HSQC Spectrum 28 Chapter 2: Materials and Methods 32 2.1: Plasmids and Peptides 32 2.2: Amplification and Isolation of Plasmids 32 2.3: Transformation 33 2.4: Bacterial Growth and Overexpression 33 2.5: Purification 34 2.6: SDS-PAGE 35 2.7: Protein Concentration Determination 36 2.8: ATPase Assay 37
Eastern european twinning on structural integrity and reliability  of advanced materials obtained through additive manufacturing

In spite of the growing importance of Additive Manufacturing (AM) technology for producing both plastics and metals parts used in different fields such as aeronautics, biomechanics and automotive, the criteria and methods for the safety evaluation of AM components are still not well established. Therefore, the lack of knowledge on the influence of the material quality on the load bearing capacity of the final product hinders the industrial exploitation of AM, preventing this powerful technology from being confidently used in every-day manufacturing processes, in particular in low developed European countries.
The overall objective of the SIRAMM project is to significantly strengthen research in the AM field at the Polytechnical University of Timisoara (UPT, Romania). To achieve this aim, SIRAMM will build upon the existing science and innovation base of UPT, creating a network with two internationally-leading counterparts at EU level: Norwegian University of Science and Technology (Norway) and the University of Parma (Italy).
In the long term, the project aims at laying the foundations for creating a pole of excellence on AM in Eastern Europe. For this reason, other two partners from low R&I performing countries, the University of Belgrade (Serbia) and the Institute of Physics of Materials, Academy of Sciences (Czech Republic) will also take part in this Twinning project.
To reach its goals, this 3-year project will be focussed on the implementation of knowledge transfer activities such as workshops and staff exchange,  training events (i.e. summer schools, seminars) for early stage researchers, and dissemination and communication actions (i.e. web site, videos, open access publications, public engagement activities) for different audiences. To keep maintaning the knowledge transfer well beyond the duration of this project, a regular master course on AM technology will be also implemented in the coordinating institution.
Optical imaging of retinal function for gene and cell therapies

For patients suffering from inherited retinal diseases (IRDs), gene and cell therapies offer hope of preserving or restoring vision. Retinal imaging is crucial, to first phenotype patients to determine which cells are degenerated and devise an appropriate therapeutic path; then in the lab for cell therapy development, and finally back in the clinic to monitor therapeutic success in patients who have been treated with gene or cell therapy. To date, the imaging tools used in the clinic do not provide sufficient resolution for visualizing individual cells non-invasively, constituting a major roadblock for the development of gene and cell therapies. 
My group develops novel optical imaging tools for noninvasive cellular imaging such as full field optical coherence tomography (FFOCT), an interferometric technique, and adaptive optics ophthalmoscopy (AOO), which corrects ocular aberrations, to achieve diffraction limited resolution of in vivo retina. Recently we also devised a dynamic FFOCT method to detect metabolic contrast using intracellular organelle motion to indicate cell activity. These new noninvasive, all optical tools have the potential to provide, for the first time, simultaneous subjective and objective retinal function measurements. Here, I propose to adapt these existing optical setups based on dynamic FFOCT and AOO to allow retinal stimulation with visible light to enable functional testing of i) patients with IRDs in order to evaluate surviving cells and orient their therapy path; ii) in vitro retinal organoids derived from induced pluripotent stem cells; ii) patients being treated in our clinical centre with novel gene and cell therapies to check that vision is being successfully preserved or restored.
The new imaging methods developed here will achieve quantitative functional assessment of cellular activity in vivo and in vitro, lifting the major imaging obstacles for successful application of gene and cell therapies in the clinic.
WASHING APPLIANCE

A washing appliance (2) is provided which is comprised of a dedicated reservoir (6) for the washing appliance (2), the reservoir (16) having an inlet (12) to allow inflow of water and an outlet (17) to enable outflow of water, and at least one heat exchange means (10) characterised in that at least one heat exchange means (10) is adapted and configured to transfer ambient energy outside the reservoir (6) into the reservoir (6).
Seasonal Precipitation and Continentality Drive Bimodal Growth of Gymnosperm Trees and Shrubs in the Mediterranean

Tree phenology is sensitive to climate warming and to changes in seasonal precipitation. Long xylogenesis records are scarce, thus limiting our ability to analyse how radial growth responds to climate variability. Alternatively, process-based growth models can be used to simulate intra-annual growth dynamics and to better understand why growth bimodality varies along temperature and precipitation gradients. We used the Vaganov-Shashkin (VS) growth model to analyse the main climatic drivers of bimodality of eight conifers (four pines and four junipers) inhabiting 11 sites across Spain. We selected sites with different continentality degree and spring/autumn precipitation ratios since we expected to find pronounced bimodal growth in less continental sites with spring and autumn precipitation peaks. The VS model predicted annual growth rates (ring-width indices) at all sites as a function of daily temperature and soil moisture data. Bimodal growth patterns clustered into less continental sites showing low spring/autumn precipitation ratios. This finding agrees with observed climate-growth associations showing that growth was enhanced by wet-cool prior winter to current spring conditions, but also by wet autumn conditions in the most bimodal sites. We observed stronger tendency of pine species for growth bimodality compared to junipers. We discuss the spatial variability of climate drivers in bimodality growth pattern and how increasing continentality and shifts in seasonal precipitation could affect growth. Bimodality could be an advantageous response to overcome summer drought in Mediterranean forests, and the ability of individual species to reactivate growth during autumn after summer quiescence might determine their adaptability to increasing summer drying of the Mediterranean region.
Climate Change and Cultural Survival in the Arctic: People of the Whales and Muktuk Politics

Abstract This article explores the interface of climate change and society in a circumpolar context, particularly experienced among the Iñupiaq people (Iñupiat) of Arctic Alaska. The Iñupiat call themselves the “People of the Whales,” and their physical and spiritual survival is based on their cultural relationship with bowhead whales. Historically the broader indigenous identity, spawned through their activism, has served to connect disparate communities and helped revitalize cultural traditions. Indigenous Arctic organizations such as the Inuit Circumpolar Conference (ICC) and the Alaska Eskimo Whaling Commission (AEWC) are currently building upon a strong success record of their past to confront the environmental problems of their future. Employing what the author calls muktuk politics—a culturally salient reference to the bowhead whale skin and the underlying blubber—the Iñupiaq have revitalized their cultural identity by participating in international debates on climate change, whaling, and human rights. Currently, the ICC and the AEWC identify Arctic climate change and its impact on human rights as their most important topics. The Iñupiat relationship with the land, ocean, and animals are affected by a number of elements including severe weather, climate and environmental changes, and globalization. To the Iñupiat, their current problems are different than those of the past, but they also understand that as long as there are bowhead whales they can subsist and thrive, and this is their goal. This new form of muktuk politics seeks to bring their current challenges to a wider audience by relying on more recent political experiences.
Sintered bodies based on aluminium titanate, process for their production and use thereof.

The present invention relates to sintered bodies based on doped aluminium titanate and mullite as the main phases, having a composition of 50 - 61.5 % by weight of Al2O3, 36 - 47.5 % by weight of titanium oxide, calculated as TiO2, and 2.5 - 5 % by weight of SiO2, the total of the three components adding up to 100 % and including up to 1 % by weight of impurities, and to processes for their production and to the use thereof.
Flow and heat transfer characteristics of falling water film on horizontal circular and non-circular cylinders

Abstract This paper presents a two-dimensional CFD study of the falling film evaporation of horizontal tubes with different shapes applied in the seawater desalination. The flow and heat transfer characteristics of the falling water film on one circular tube and two non-circular shaped tubes, a drop-shaped tube and an oval-shaped tube, are analyzed, respectively. The Volume Of Fluid (VOF) method is employed to investigate the influence of the mass flow rate and the feeder height on the distribution of the film thickness and the heat transfer performance. The numerical results show that the minimum value of the film thickness appears approximately at the angular positions of 125°, 160° and 170° for the smooth circular, oval- and drop-shaped tubes, respectively. The film thickness grows with the increase of the mass flow rate and the decrease of the feeder height, while the variation pattern varies for different tubes. Moreover, compared with the circular tube, the drop- and oval-shaped tubes have a lower dimensionless temperature and a thinner thermal boundary layer, which means a better heat transfer performance. Finally, the numerical results correlate well with the experimental and predicted data in literature.
Memory of fearful events: the role of fibroblast growth factor-2 in fear acquisition and extinction

Research during the past decade has led to a tremendous growth in our understanding of how fear memories are acquired and subsequently inhibited on a neural and molecular level. Such research has contributed to significant developments in the treatment of anxiety disorders, and has considerably advanced our understanding of the neurobiology of learning and memory in general. A number of recent studies have examined the role of growth factors in the formation of long-term memory for fearful events, due to their ability to cause morphological neural changes in response to environmental stimulation. In this review we first describe physiological evidence that fibroblast growth factor-2 (FGF2) receptors are highly expressed in the neural circuitry regulating fear acquisition and extinction, and that FGF2 modulates the molecular signals known to be involved in the formation of fear memories. Then we present emerging behavioral research that demonstrates that exogenous FGF2 can enhance the formation of fear conditioning and extinction memories. Finally, we briefly discuss how research into the role of FGF2 in learning and memory may be of clinical benefit, particularly in the treatment of anxiety disorders. ▶FGF2 modulates the molecular cascade of memory. ▶FGF2 affects fear acquisition, and could be a potential memory enhancer. ▶FGF2 affects fear extinction, and could be a pharmacological adjunct for exposure therapy.
“Dna-Based nanodevices for the point-of-care electrochemical detection of antibodies”

WHY: Antibody detection plays a pivotal role in the diagnosis of many human disorders including infectious, autoimmune, and oncological diseases. Unfortunately, current methods routinely used for the detection of these biomarkers still require sophisticated equipment, washing intensive, reagent-intensive multi-step processes. In attempt to overcome the cited limitations, it’s mandatory find new approaches for the sensitive detection of antibodies. 
WHAT: DNA-NANO-AB proposes the development of DNA-based novel, rapid, user friendly, robust, sensitive and low cost electrochemical NANOdevices for orthogonal multiplex detection of antibodies that may be advantageous over existing methods for the detection of clinically-relevant antibodies and could be well-positioned for point-of-care applications. 
I will achieve this goal by rationally designing and fabricating disposable DNA-based sensing platforms in which the detection of specific antibodies will be signaled, and amplified, through an electrochemical read-out approach. The developed platforms will be characterized, optimized and then tested for the dosage of immunoglobulins levels directly in real representative samples. 
HOW: During the fellowship I will undertake a training program to develop skills and acquire expertise in molecular biology, electrochemical biosensor and DNA Nanotechnology. To achieve these objectives, I will combine the different scientific backgrounds and expertise of two leading scientists: Prof. Plaxco (University of California Santa Barbara), a world-wide expert in electrochemical biosensors, and Prof. Ricci (University of Rome, Tor Vergata), a young researcher active at the forefront of DNA nanotechnology for diagnostic and drug-delivery applications. Thanks to this MSC Fellowship, I will diversify my scientific knowledge and acquire cutting-edge competences as well as complementary skills, which will become the foundation of my scientific independence.
Temporal Changes in Coupled Vegetation Phenology and Productivity are Biome-Specific in the Northern Hemisphere

Global warming has greatly stimulated vegetation growth through both extending the growing season and promoting photosynthesis in the Northern Hemisphere (NH). Analyzing the combined dynamics of such trends can potentially improve our current understanding on changes in vegetation functioning and the complex relationship between anthropogenic and climatic drivers. This study aims to analyze the relationships (long-term trends and correlations) of length of vegetation growing season (LOS) and vegetation productivity assessed by the growing season NDVI integral (GSI) in the NH (&gt;30°N) to study any dependency of major biomes that are characterized by different imprint from anthropogenic influence. Spatial patterns of converging/diverging trends in LOS and GSI and temporal changes in the coupling between LOS and GSI are analyzed for major biomes at hemispheric and continental scales from the third generation Global Inventory Monitoring and Modeling Studies (GIMMS) Normalized Difference Vegetation Index (NDVI) dataset for a 32-year period (1982–2013). A quarter area of the NH is covered by converging trends (consistent significant trends in LOS and GSI), whereas diverging trends (opposing significant trends in LOS and GSI) cover about 6% of the region. Diverging trends are observed mainly in high latitudes and arid/semi-arid areas of non-forest biomes (shrublands, savannas, and grasslands), whereas forest biomes and croplands are primarily characterized by converging trends. The study shows spatially-distinct and biome-specific patterns between the continental land masses of Eurasia (EA) and North America (NA). Finally, areas of high positive correlation between LOS and GSI showed to increase during the period of analysis, with areas of significant positive trends in correlation being more widespread in NA as compared to EA. The temporal changes in the coupled vegetation phenology and productivity suggest complex relationships and interactions that are induced by both ongoing climate change and increasingly intensive human disturbances.
The role of the serotonin 5-ht4 receptor in motor and non-motor symptoms of parkinson’s disease

Parkinson’s Disease (PD) is caused by dopaminergic neuron loss resulting in motor symptoms that are treated with L-DOPA.
However, ≤90% of patients develop involuntary movements, termed L-DOPA induced dyskinesia (LID). Another less well studied, but
highly occurring PD symptom is depression.
There is evidence that the serotonin system is implicated in both, LID and PD-linked depression. Serotonergic (5-HT) neurons
uncontrollably release L-DOPA-derived dopamine, and HTR1a/b agonists counteract such release and LIDs. Serotonin re-uptake
inhibitors (SSRIs) also attenuate LID, through a still unknown mechanism. The striatally enriched Gαs-coupled receptor, HTR4, has the
potential to enhance excitability of spiny projection neurons, to affect the balance of striatal pathways that is disrupted in PD and is a
candidate to modulate LID and PD-depression.
D2 agonists reduce depressive behavior in PD models, pointing towards a role for the striatum. Specifically, the dorsolateral striatum
shows diminished metabolism, in contrast to non-PD-depression where the ventral striatum is a substrate. HTR4 in cortex and
hippocampus was linked to antidepressant action. Agonists and overexpression yield anti-depressant-like responses, however,
striatal HTR4 in PD-depression has not been examined.
1. We will determine HTR4 protein expression on a cellular level (dSPNs, iSPNs) in transgenic mice. We will virally overexpress,
knockdown and pharmacologically manipulate HTR4 and assess striatally-driven behaviors.
2. We will probe HTR4 in motor symptoms by altering expression/activity in unilaterally 6-OHDA lesioned mice. We will evaluate LID
onset/severity, dyskinesia markers and LTP, depotentiation and LTD.
3. We will test bilaterally-lesioned mice with altered HTR4 expression/activity in depression/anxiety paradigms. We will determine
the effect on the action of D2, HTR1a agonists and SSRIs.
Our comprehensive investigation of HTR4 will lead to a new understanding and treatment of PD.