SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Petrogenesis and geodynamic implications of Ediacaran highly fractionated A-type granitoids in the north Arabian-Nubian Shield (Egypt): Constraints from whole-rock geochemistry and Sr-Nd isotopes

Abstract Mineral chemistry, whole-rock geochemical and Sr–Nd isotopic data are reported for the Abu-Diab granitoids in the northern Arabian-Nubian Shield (ANS) of Egypt, to investigate their petrogenesis and geodynamic significance. Gabal Abu-Diab constitute a multiphase pluton, consisting largely of two-mica granites (TMGs) enclosing microgranular enclaves and intruded by garnet bearing muscovite granites (GMGs) and muscovite granites (MGs). The granitoids are weakly peraluminous (A/CNK = 1.01–1.12) and show high SiO2 (>72.9 wt%) and alkali (K2O + Na2O = 8.60–9.13) contents. The geochemical features show that they are post-collisional and highly fractionated A-type granitoids. Compared to their host TMGs, the microgranular enclaves are strongly peraluminous (A/CNK = 1.18–1.24) with lower SiO2 and higher abundances of trace elements. The TMGs are depleted in Ba, Nb, P and Ti and are enriched in LREEs relative to HREEs with weakly negative Eu anomalies (Eu/Eu* = 0.45–0.64). In contrast, the GMGs and MGs are extremely depleted in Ba, Sr and Ti and have tetrad-type REE patterns (TE1–3 = 1.1–1.3) with strongly pronounced negative Eu anomalies (Eu/Eu* = 0.03–0.26), similar to rare metals bearing granites. The Ediacaran (585 ± 24 Ma) TMGs, are characterized by restricted and relatively low initial 87Sr/86Sr ratios (0.70337–0.70382) that suggests their derivation from a depleted mantle source, with little contamination from the older continental crust. In contrast, the GMGs and MGs have extremely high 87Rb/86Sr and 87Sr/86Sr ratios that reflect the disturbance of the Rb-Sr isotopic system and may give an indication for magmatic-fluid interaction. However, all the granitoids display positive eNd(t) (4.41–6.57) and depleted mantle model ages TDM2 between 777 and 956 Ma, which indicate their derivation from a Neoproterozoic juvenile magma sources and preclude the occurrence of pre-Neoproterozoic crustal rocks in the ANS. The microgranular enclaves represent globules of hot mafic magma that have injected and partly mixed with the colder and more felsic TMGs magma. Geochemical and isotopic data along with petrogenetic modelling, suggest that the TMGs were formed by low degrees of partial melting of the pre-existing I-type granodiorites, followed by extensive fractional crystallization and fluid fractionation to produce the geochemically specialized rare metals GMGs and MGs in the margin of Abu-Diab pluton. During the post-collisional stage of ANS and due to lithospheric delamination processes, the underplated fluid/volatile rich mantle magma had interplated and migrated upward to shallow crustal levels, through extensional faults/shear zones, and enhanced the partial melting and fractionation of granodiorites to eventually form Abu-Diab A-type granitoids.
Kgyat have developed the rvcr, the world’s first commercially viable rotary variable compression ratio (vcr) engine.

KGYAT have developed RVCR, the world’s first commercially viable Variable Compression Ratio (VCR) engine. KGYAT’s proprietary RVCR (Rotary Variable Compression Ratio) engine technology combines into one high-tech powertrain the specific output and performance advantages of rotary motors and the thermal efficiency gains from VCRs. This enables the RVCR engine to eliminate the complexities in conventional crank mechanism-based VCRs and offer the advantages of; multiple fuel flexibility, efficiency gains by 30%, lower emissions, and reduced cost, making it the world’s first commercially viable VCR engine. This disruptive, highly efficient fuel-flexible ""RVCR engine will enable a smooth transition from 20th century fossil fuel dependency to 21st century green fuels without disrupting the existing fossil-fuel based economic structures.
RVCR has been prototyped within a laboratory environment, however KGYAT is now looking to gain funding to: demonstrate and validate the performance of a 75kW RVCR engine on a test bed for product qualification; and industrialisation of the RVCR engine with an engine manufacturer, including a design for manufacturing and assembly and the optimisation of costs, demonstrating viability of high volume production. 
Due to RVCR’s robustness and efficiency it is a perfect solution to reduce emissions and fuel consumption of passenger cars.
Diurnal and Seasonal Lightning Variability over the Gulf Stream and the Gulf of Mexico

Recent observations from the World Wide Lightning Location Network (WWLLN) reveal a pronounced lightning maximum over the warm waters of the Gulf Stream that exhibits distinct diurnal and seasonal variability. Lightning is most frequent during summer (June–August). During afternoon and early evening, lightning is enhanced just onshore of the coast of the southeastern United States because of daytime heating of the land surface and the resulting sea-breeze circulations and convection. Near-surface wind observations from the Quick Scatterometer (QuikSCAT) satellite indicate divergence over the Gulf of Mexico and portions of the Gulf Stream at 1800 LT, at which time lightning activity is suppressed there. Lightning frequency exhibits a broad maximum over the Gulf Stream from evening through noon of the following day, and QuikSCAT wind observations at 0600 LT indicate low-level winds blowing away from the continent and converging over the Gulf Stream. Over the northern Gulf of Mexico, lightning is most frequent from around sunrise through late morning. During winter, lightning exhibits a weak diurnal cycle over the Gulf Stream, with most frequent lightning during the evening. Precipitation rates from a 3-hourly gridded dataset that incorporates observations from Tropical Rainfall Measuring Mission (TRMM), as well as other satellites, exhibit a diurnal cycle over the Gulf Stream that lags the lightning diurnal cycle by several hours.
Suicidal ideation in adolescence: Examining the role of recent adverse experiences

Although there is a well-known link between adverse experiences and suicidal ideation, there has been little study of the effects of recent adverse experiences on suicidal ideation in teenagers. This study examined the association between recent adverse experiences and suicidal ideation in a sample of 740 at-risk 16-year-old youth in the LONGSCAN studies, as well as potential mediators. 8.9% of the youth reported suicidal ideation. Recent adverse experiences, as a class, were associated with suicidal ideation; both recent physical abuse and recent psychological maltreatment were uniquely associated with suicidal ideation. The links between recent adverse experiences and suicidal ideation were significantly mediated by psychological distress. There were also significant main effect associations between both internalizing behavioral problems and low positive achievement expectations and suicidal ideation. Recent adverse experiences are important in understanding suicidal ideation in high risk youth.
Integrated property database and search engine

An integrated property database and search engine for matching properties with buyers has a computer that includes a master database and a search engine. The master database includes a property for sale database and a buyer's database. The property for sale database includes a property identification, a property location, and a property price. The buyers database includes a buyer's identification, a location of interest, and an offer price. A request is sent to the buyer for ascertaining information to be contained in the buyers database. An inquiry is sent to ascertain information to be contained in the property for sale database. A search engine is used to identify properties in the property for sale database that have a property location within the location of interest for a buyer, and have a property price that is equal to or lower than the offer price.
Fault-tolerant wide-area control for power oscillation damping

In this paper, the effectiveness of using both local and remote (wide-area) feedback signals for power oscillation damping (POD) controllers is shown. However, the challenge is to guarantee a minimum level of dynamic performance with only the local signal following sudden loss of remote signals. A case study on the Nordic equivalent system is presented to show that the closed-loop response could deteriorate once the remote signals are lost. A fault-tolerant control (FTC) design methodology is presented to solve this problem and ensure an acceptable performance level even in case of loss of remote signals. The FTC design methodology is based on simultaneous pole-placement for normal and loss of (remote) signals conditions along with minimisation of control effort. The problem is solved non-iteratively using Linear Matrix Inequalities (LMIs). Under the normal condition (when both local and remote signals are present) the fault-tolerant controller (FTC) requires more control effort as compared to a conventional controller (CC) in order to achieve the same performance. However, case studies on the Nordic equivalent system confirm that the proposed FTC is able to produce acceptable performance in case of loss of the remote signals while the response with a CC is unacceptable.
Astrometry with MCAO: HST-GeMS proper motions in the globular cluster NGC 6681

Aims: for the first time the astrometric capabilities of the Multi-Conjugate Adaptive Optics (MCAO) facility GeMS with the GSAOI camera on Gemini-South are tested to quantify the accuracy in determining stellar proper motions in the Galactic globular cluster NGC 6681. Methods: proper motions from HST/ACS for a sample of its stars are already available, and this allows us to construct a distortion-free reference at the epoch of GeMS observations that is used to measure and correct the temporally changing distortions for each GeMS exposure. In this way, we are able to compare the corrected GeMS images with a first-epoch of HST/ACS images to recover the relative proper motion of the Sagittarius dwarf spheroidal galaxy with respect to NGC 6681. Results: we find this to be (\mu_{\alpha}cos\delta, \mu_{\delta}) = (4.09,-3.41) mas/yr, which matches previous HST/ACS measurements with a very good accuracy of 0.03 mas/yr and with a comparable precision (r.m.s of 0.43 mas/yr). Conclusions: this study successfully demonstrates that high-quality proper motions can be measured for quite large fields of view (85 arcsec X 85 arcsec) with MCAO-assisted, ground-based cameras and provides a first, successful test of the performances of GeMS on multi-epoch data.
Transalpine Transport Architects

In TRANSITECTS public institutions design common transnational intermodal solutions for freight transport in the Alpine Space. In the partnership different interests (economy, environment and transport) are integrated which is of crucial importance for a sustainable solution. Main aim of the project is to make the rail network more attractive and hence to foster its accessibility and functionality for the logistic market. The focus lies on developing innovative transnational rail services, on optimizing the use of existing rail infrastructure and on improving the accessibility of inland terminals. One innovative approach of the project is that it doesn't stop on the borders of Alpine Space as the traffic does neither. By cooperating closely with other European initiatives it creates synergies and leverage effects that have positive impacts on the Alpine Space and beyond. With these joint activities the project contributes to both, mitigation of negative effects of freight transport and promotion of the accessibility by rail.
Urban ecologies: governing nonhuman life in global cities

A fundamental dimension of planetary urbanization is its radical transformation of nature.  Domestic animals now make up more than twice the biomass of humans on the planet.  They are vital to livelihoods of the urban poor in the global south, providing economic opportunities, yet posing zoonotic risks.  In contrast, cities of the north are marked by the paucity of animals and concomitant health concerns.  Yet, urban ecologies – relations between people and animals, and their interactions with the built environment – have received scant systematic attention in the social sciences.

The objective of this project is to lay bare how regulating nonhuman life is fundamental to governing global cities.  How are human-animal dynamics differentially composed in cities of the global south and north?  What social, economic and spatial forces structure these dynamics?  Most global cities regulate animal presence, albeit with varying degrees of success.  How then might an expanded notion of urban governance incorporating ecology reorient urban studies?  And finally, how might such an analysis help promote resilient and sustainable cities?

The project tackles these questions through a comparative analysis focused on New Delhi, Guwahati and London.  Using a combination of conventional ethnographic research methods and innovative ecological perspectives, it will generate novel explanatory concepts for understanding urban ecologies and their implications for governing global cities.

This research is ground-breaking in four ways: 1) by addressing an uncharted but critical field of human action, it sheds new light on urban governance; 2) by integrating adjacent disciplines that seldom interact, it pushes the frontiers of urban studies; 3) by combining social and ecological perspectives, it adds to methodological innovation in the social sciences; 4) by accounting for how ecology shapes marginalized lives, it contributes to new agendas of making cities resilient for the urban poor.
Enforced atp wasting as a general design principle to rationally engineer microbial cell factories

One global challenge of humanity in the 21st century is the shift from a petrochemical to a bio-based production of chemicals and fuels. An enabling technology towards this goal is metabolic engineering which uses computational and experimental methods to construct microbial cell factories with desired properties. While it has been shown that genetically engineered microorganisms can, in principle, produce a broad range of chemicals, novel approaches to improve the performance of those strains are urgently needed to develop economically viable bioprocesses.
To this end, we propose a new metabolic design principle to rationally engineer cell factories with high performance. Supported by a recent pilot study, we postulate that suitable genetic interventions combined with mechanisms that burn (waste) an extra amount of ATP (e.g., by artificial futile cycles) will increase product yield and productivity of many microbial production strains. Key objectives of StrainBooster are therefore: (1) to use computational techniques and metabolic models to identify gene knockout strategies whose coupling with ATP wasting mechanisms can boost the performance of microbial strains and to prove in silico that those strategies exist for many combinations of substrates, products, and host organisms; (2) to develop genetic modules that can robustly increase ATP dissipation in the cell; and (3) to experimentally demonstrate the power of the proposed strategy for selected production processes with Escherichia coli. To reach these ambitious goals, an interdisciplinary approach will be pursued combining theoretical and experimental studies and making use of innovative methods from systems and synthetic biology.
If successful, StrainBooster will not only establish a new and ground-breaking strategy for metabolic engineering, it will also deliver novel computational tools and genetic parts facilitating direct application of the approach to design and optimize industrial fermentation processes.
Exploring the hidden life of african trypanosomes: parasite fat tropism and implications for disease

Background: The study of protozoan pathogens has been extensively explored often motivated to find suitable targets for new intervention strategies. However these studies have been mostly limited to those life-cycle stages that can be cultivated in vitro. Using a mouse model of African trypanosomiasis, we have recently discovered that the adipose tissue (fat) is a major reservoir for the extracellular protozoan Trypanosoma brucei and that, within this environment, parasites become phenotypically different from those in the blood. Our study exposed novel biology of the T. brucei life cycle, yet it remains unknown how parasites adapt to the fat and how parasite fat tropism affects disease.

Our first aim is to determine the molecular and cellular mechanisms underlying T. brucei fat tropism. We will perform a genetic screen in mice to identify key parasite genes required for establishing and maintaining chronic infection in the fat. Together with the information of the transcriptome and proteome, we will identify the mechanistic steps underlying parasite tissue-adaptation.

Our second aim is to identify the consequences of T. brucei fat tropism for the host and the importance for disease. We will first investigate if parasites can egress from the fat. We will also determine if parasites induce lipid breakdown in the host, leading to loss of fat mass. Finally, we will measure the impact of fat tropism in general traits of disease, including host survival and transmission potential.

Impact: This project represents a completely novel research avenue built on recent work from my laboratory. By uncovering fundamental aspects of the biology of T. brucei, we will also improve the understanding of clinically relevant features of African trypanosomiasis, including relapses and weight loss. In addition, since parasite fat tropism has also been observed in malaria and Chagas’ disease, our findings will help elucidate disease mechanisms relevant to other infectious diseases.
COMBINATION OF THE ANALEPTIC MODAFINIL AND AN ANTIDEPRESSANT FOR THE TREATMENT OF DEPRESSION

Compositions and methods for the treatment of depressive disorders through the administration of modafinil with antidepressants.
Deciding to Urban-Migrate and Agricultural Development: Evidence from the Millennium Challenge Account (MCC)-Millennium Development Authority (MiDA) Intervention Zones, Ghana

The decision to migrate involves both “push” and “pull” factors. Push factors force migrants out of rural areas while pull factors attract rural folks to the urban areas. The information set which displays the realities on the ground, if positive will motivate a potential migrant to move to an urban area and vice versa. Movement of labour for agriculture in the rural areas decreases resources needed to help promote the needed growth in the sector. With a sample size of 46,110 household members from two batches (about 3000 farmers/households for each batch) of selected farmers who enjoyed agricultural interventions (technology), a probit model is estimated to find the factors that influence the decision to urban-migrate. In particular we discuss the question of whether the MiDA intervention through the training of farmers on various techniques/technologies to be more productive, has had an impact on farmers’ as well as their household members’ decision to urban-migrate. Generally, household, Farmer Based Organization and individual characteristics were considered in the model. We find that, farmers and their household members in the Southern Horticultural belt were less likely to migrate while those in the Northern Agricultural Zone were more likely to migrate to the urban area. Education, households with returned migrants, and remittances were positive in influencing the decision to urban-migrate. On the other hand, being self-employed and being married reduces the probability that an individual will migrate. Generally, the differential economic opportunities through the relative increased knowledge in the urban areas remain a pull factor of labour resources of the undeveloped rural agricultural sector. Bridging the gap between the expected income differential of rural and urban areas resulting from differences in knowledge and opportunities will be the key to reducing this phenomenon as suggested by [4] and many other studies.
STRUCTURE FOR DRYING A COMPONENT OF A BUILDING

The invention relates to a structure (1), for example a flexible structure (1), for heating a component (5) of a building, wherein the component is in particular a wall (5) and/or a floor and/or a ceiling, the structure having a heating system (3) and permeable insulation (2), the heating system (3) being designed in such a way that the component (5) can be heated by heat provided by the heating system, and the permeable insulation (2) being arranged or being able to be arranged in such a way that transport of the heat provided by the heating system (3) into the heating-system-side environment (6) of the component (5) can be reduced. The structure (1) is characterised in that a partition (7) is provided at a distance from the permeable insulation (2) and delimits a layer (8), which is drained and/or through which a fluid can pass, between the permeable insulation (2) and the partition (7).
A systems medicine approach to chronic inflammatory disease

The SYSCID consortium aims to develop a systems medicine approach for disease prediction in CID. We will focus on three major CID indications with distinct characteristics, yet a large overlap of their molecular risk map: inflammatory bowel disease, systemic lupus erythematodes and rheumatoid arthritis. We have joined 15 partners from major cohorts and initiatives in Europe (e.g.IHEC, ICGC, TwinsUK and Meta-HIT) to investigate human data sets on three major levels of resolution: whole blood signatures, signatures from purified immune cell types (with a focus on CD14 and CD4/CD8) and selected single cell level analyses.  Principle data layers will comprise SNP variome, methylome, transcriptome and gut microbiome. SYSCID employs a dedicated data management infrastructure, strong algorithmic development groups (including an SME for exploitation of innovative software tools for data deconvolution) and will validate results in independent retrospective and prospective clinical cohorts. 
Using this setup we will focus on three fundamental aims : (i) the identification of shared and unique ""core disease signatures” which are associated with the disease state and independent of temporal variation, (ii) the generation of ""predictive models of disease outcome""- builds on previous work that pathways/biomarkers for disease outcome are distinct from initial disease risk and may be shared across diseases to guide therapy decisions on an individual patient basis, (iii) ""reprogramming disease""- will identify and target temporally stable epigenetic alterations in macrophages and lymphocytes in epigenome editing approaches as biological validation and potential novel therapeutic tool  .
Thus, SYSCID will foster the development of solid biomarkers and models as stratification in future long-term systems medicine clinical trials but also investigate new causative therapies by editing the epigenome code in specific immune cells, e.g.  to alleviate macrophage polarization defects.
Fully digital, static, true single-phase clock (TSPC) flip-flop

Disclosed is a flip-flop (FF) (e.g., a D-type flip-flop (DFF) or a scan flip-flop (SFF)). The FF is configured to reduce dynamic power consumption of an integrated circuit (IC) by employing only a single-phase of a clock signal. Specifically, the FF includes a primary latch and a secondary latch. Each of these latches includes a multi-stage input driver, which internally generates a control signal based on both the single-phase clock signal and an input signal and which also generates a stored bit signal based on the control signal. Each of these latches can also include a feedback path with an inverter that inverts the stored bit signal and a tri-state logic device that generates a feedback signal that is dependent on the inverted stored bit signal, the control signal and the clock signal. As a result, the FF is a fully digital, static, true single-phase clock (TSPC) flip-flop.