SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Integrated and adaptive responses to toxic emergencies for rapid triage:                   engineering the roadmap from casualty to patient to survivor.

The seven specific objectives of TOXI-triage address the operational; technological; ethical and societal dimensions of CBRN response and recovery, and importantly the economic base from which sustainable CBRN and multi-use systems are derived.
19 partners in 4 Task forces will deliver 9 Work Packages (WPs) that address: end user specifications; Design and delivery; Test and Validation; and, Impact. The approach defines a concept of operations that envisages accelerated delivery of situational awareness through an ensemble of embedded sensors, drones, standoff detectors (including cameras), artificial intelligence for processing sensor signals and web-traffic from social media, and centralised command and control.  Wireless traceability of casualties provides dynamic mapping including medical care. 2 field exercises are intended to test and verify the operational attributes of the systems, and 3 WPs focus on impact to deliver: Exploitation; Security and Ethics; and Effective Innovation Management. 
Distinctive technological attributes of TOXI-triage include: rapid non-invasive assessment of exposure/ injury through monitoring metabolic markers of injury; managing and exploiting the semantic web; traceability by design; aptamer-based  bio-sensing; casualty-to-discharge system integration; and integrated environmental and stand-off hazard designation. The approach is rigorous with clinical trials to test systems in poisoning clinics and live agent tests in laboratories designated by the UN’s OPCW.
Distinctive societal attributes of TOXI-triage include: addressing the needs of all vulnerable groups; optimising inter-cultural/ethnic messages and needs in CBRN response; fostering economic impact by multiple-uses for all the project’s systems. TOXI-triage intends that its outcomes will be used routinely in medical/environmental/urban and search and rescue emergencies. The benefits are intended to extend significantly further then enhanced CBRN resilience
Comparison of Keratometric Values Measured by the Handheld Autokeratometer, On-table Autokeratometer and Manual Keratometer

Purpose: To compare the keratometry measurements by the handheld Nikon Retinomax K-plus2, the on-table Canon RK-5 autokeratometer, and the manual Topcon OM-4 keratometer and to evaluate the degree of agreement among the three instruments. Methods: Adults (n=30) and children (n=40) presenting toa tertiary eye hospital clinic were examined by an optometrist. Topcon OM-4 keratometer, Nikon Retinomax and the on-table Canon RK-5 autokeratometer analyses were performed in order. The horizontal and vertical keratometry data were measured. The vector components of astigmatism, mean bias and agreement among the three types of measurements were evaluated. Results: There were no significant differences among the three keratometers in horizontal or vertical keratometry or in central corneal astigmatism in both the adult and child groups (p-value>0.05). The keratometers which were estimated with Retinomax K-plus2 were highly correlated with those by on-table RK-5 autokeratometer (min. 0.89, max. 0.97) and Topcon OM-4 keratometer (min. 0.67, max. 0.94) in the adult group, while in the child group, the three instruments showed slightly decreased correlation (min. 0.45, max. 0.97 on RK-5, min. 0.36, max. 0.92 on OM-4), especially in the left eyes. Conclusions: The handheld Retinomax K-plus2 provided comparable data to that of the conventional on-table Topcon and manual keratometers. This instrument will beuseful in the clinic to measure keratometry in children or immobilized patients who have difficulty sitting during the examination.
Virus-X: viral metagenomics for innovation value

Biological sequence diversity in nowhere as apparent as in the vast sequence space of viral genomes. The Virus-X project will specifically explore the outer realms of this diversity by targeting the virosphere of selected microbial ecosystems and investigate the encoded functional variety of viral gene products. The project is driven by the expected large innovation value and unique properties of viral proteins, previously demonstrated by the many virally-derived DNA and RNA processing enzymes used in biotechnology. Concomitantly, the project will advance our understanding of important aspects of ecology in terms of viral diversity, ecosystem dynamics and virus-host interplay. Last but not least, due to the inherent challenges in gene annotation, functional assignments and other virus-specific technical obstacles of viral metagenomics, the Virus-X project specifically addresses these challenges using innovative measures in all parts of the discovery and analysis pipeline, from sampling difficult extreme biotopes, through sequencing and innovative bioinformatics to efficient production of enzymes for molecular biotechnology. Virus-X will advance the metagenomic tool-box significantly and our capabilities for future exploitation of viral biological diversity, the largest unexplored genetic reservoir on Earth.
Space-Time from information flow

The aim of this proposal is to develop a novel multidisciplinary approach to space-time physics which combines core features of quantum theory and general relativity by using modern tools of information theory. Recent results manifest a deep relation between space-time structure and the possibility of certain abstract quantum communication tasks. We shall build upon these results to identify precise operational conditions on abstract quantum communication which permit observers to describe their environment as a classical space-time. This procedure will be expanded to spatiotemporal structures in a semiclassical regime with an emphasis on how the feasibility of communication tasks is influenced. Exploiting these insights, we shall devise a novel framework for (quantum) gravitational physics to generating spatiotemporal structure from the internal information flow of an operationally defined network. This research programme may foster new perspectives on space-time physics by providing it with information theoretic foundations and is intended to complement, rather than compete with, already existing approaches to (quantum) gravity.

The fellowship will reintegrate the researcher from Canada into the EU and, at the same time, support the cross-community move of a (quantum) gravity expert into a quantum foundations group. The proposed programme requires expertise from various disciplines in theoretical physics and will thereby diversify the competences of both the researcher and the host group, as well as expand their respective networks of collaborators. This action supports European excellence in science and prepares the fellow for a more permanent position by endowing him with crucial opportunities to train his mentoring, communication and networking skills and, ultimately, by allowing him to develop his own research programme.
A new multi-objective stochastic model for a forward/reverse logistic network design with responsiveness and quality level

Logistic network design has an important and strategic platform in an efficient and effective supply chain management, and usually involves multiple and conflicting goals, such as cost/profit, resource balance, customer responsiveness, quality, and the like. Besides, due to the implementation of government legislation, environmental concern, social responsibility and customer awareness, companies have been forced by customers not only to supply environmentally amicable products but also to be responsible for the returned products. Hence, this paper presents a stochastic multi-objective model for forward/reverse logistic network design under a uncertain environment including three echelons in forward direction (i.e., suppliers, plants, and distribution centers) and two echelons in backward direction (i.e., collection centers and disposal centers). We demonstrate a method to evaluate the systematic supply chain configuration maximizing the profit, customer responsiveness, and quality as objectives of the logistic network. The set of Pareto optimal solutions is obtained and also financial risk relevant to them is computed in order to show the tradeoff between objectives. The results give important insight for fostering the decision making process.
Roads to memory: studying the regulation of lymphocyte stemness by fate mapping of single t and nk cells

Almost two decades ago it was first proposed that immunological memory may depend on stem cell-like mechanisms, enabling individual antigen-specific T and B cells to generate progeny that contains short-lived effectors as well as long-lived memory cells. To test this capacity, I have in the past developed a stringent set of single cell-based approaches, which allowed me to show that single CD8+ and CD4+ T central memory cells harbour the capacity to self-renew and generate a diverse offspring of effector cells, but also, show immense variation in executing these essential functions upon activation.
Thus, even physiological immune responses to infection appear not to harness the full protective potential available in every antigen-specific lymphocyte. To better understand the regulatory principles underlying this single-cell derived variation, in the context of classical T-cell memory, T-cell exhaustion and memory-like NK cell responses, I developed novel fate mapping technologies such as ‘single-cell colour barcoding’ and ‘single-cell RNA barcoding’. I will now integrate these approaches with single-cell RNA sequencing, genetic reporter systems and continuous live-cell imaging, to answer three fundamental questions in immunobiology:
1) Do exhausted T-cell responses to chronic infection and adaptive-like immune responses of NK cells also rely on the stem cell-like potential of individual cells? 2) Do single-cell-derived T and NK cell families enter the memory or memory-like exhausted compartment on a direct road or through de-differentiation, after passing through an early effector state? And 3) how is the development of these T and NK cell families influenced by their founding members’ fundamental cellular properties, such as asymmetric cell-division, quorum sensing and cell-cycle speed? Answering these questions will help to identify new molecular targets and therapeutic strategies to enhance or reinvigorate protective immunity against infection or malignancy.
SMALL RNAs AND BACTERIAL STRAINS INVOLVED IN QUORUM SENSING

Quorum-sensing bacteria communicate with extracellular signal molecules called autoinducers to allow community-wide synchronization of gene expression. The present invention relates to the identification of Vibrio harveyi and Vibrio Cholerae protein Hfq as mediating interactions between small, regulatory RNAs (sRNAs) and specific messenger RNA (mRNA) targets. Accordingly, the present invention provides nucleic acids encoding the Vibrio sRNAs, strains having various deletions and mutations of one or more qrr genes encoding these sRNA as well as methods of identifying quorum-sensing regulators. Additionally, the invention relates to an isolated V. harveyi Hfq protein and conservative amino acid substitutions thereof as well as nucleic acids encoding those proteins, recombinant methods of producing those proteins and antibodies against those proteins.
Brain Iron Metabolism and Brain Injury Following Subarachnoid Hemorrhage: iCeFISH-Pilot (CSF Iron in SAH)

Iron-mediated oxidative damage has been implicated in the genesis of cerebral vasospasm in animal models of SAH. We sought to explore the relationship between levels of non-protein bound iron in cerebrospinal fluid and the development of brain injury in patients with aneurysmal SAH.Patients admitted with aneurysmal subarachnoid hemorrhage to a Neurointensive care unit of an academic, tertiary medical center, with Hunt and Hess grades 2-4 requiring ventriculostomy insertion as part of their clinical management were included in this pilot study. Samples of cerebrospinal fluid (CSF) were obtained on days 1, 3, and 5. A fluorometric assay that relies on an oxidation sensitive probe was used to measure unbound iron, and levels of iron-handling proteins were measured by means of enzyme-linked immunosorbent assays. We prospectively collected and recorded demographic, clinical, and radiological data.A total of 12 patients were included in this analysis. Median Hunt and Hess score on admission was 3.5 (IQR: 1) and median modified Fisher scale score was 4 (IQR: 1). Seven of 12 patients (58 %) developed delayed cerebral ischemia (DCI). Day 5 non-transferrin bound iron (NTBI) (7.88 ± 1 vs. 3.58 ± 0.8, p = 0.02) and mean NTBI (7.39 ± 0.4 vs. 3.34 + 0.4 p = 0.03) were significantly higher in patients who developed DCI. Mean redox-active iron, as well as day 3 levels of redox-active iron correlated with development of angiographic vasospasm in logistic regression analysis (p = 0.02); while mean redox-active iron and lower levels of ceruloplasmin on days 3, 5, and peak concentration were correlated with development of deep cerebral infarcts.Our preliminary data indicate a causal relationship between unbound iron and brain injury following SAH and suggest a possible protective role for ceruloplasmin in this setting, particularly in the prevention of cerebral ischemia. Further studies are needed to validate these findings and to probe their clinical significance.
Digital enterprise innovations for bioimaging, biosensing and biobanking industries

DIGI-B-CUBE project aims to unlock the cross-sectoral collaborative potential of SMEs by combining Artificial Intelligence (AI), Cognitive Computing Digital Technologies (CCDT) with the Bioimaging-Biosensing-Biobanking (B-CUBE) and realted industries to deliver market sensitive disruptive technologies and generating innovative solutions that enhance patient-centred diagnostic work-flows, delivered through the improved algorithms for Medical Diagnostics’ efficiency and accuracy. DIGI-B-CUBE will study the characteristics in market dynamics & specificities for innovations created by merging AI, CCDT & B-CUBE and realted industries. By providing a framework for a more structured cross-sectoral and cross-border collaboration, that manages all the complex work-flows within the process, DIGI-B-CUBE instantiates the mechanisms to ensure the long-term sustainability of the action through collaborations of the participating clusters with hospitals, academia, industry, investors, business angels, managing authorities of the national innovation agencies and the European Commission support measures (such as EIT, ESIF). The main objective of this project is to provide key digital solutions for the reconfiguration of the Medical Diagnostics and related value chains towards a Health Economy 4.0 with a special focus on Biobanking, Bioimaging and Biosensing and realted industries. Activities financed by the ESIF in the participating regions as part of the Smart Specialisation Strategies will be bundled in cooperation with the responsible managing authorities in addition to the innovation voucher scheme for SMEs. By integrating innovations in IT into Bioimaging, Biosensing and Biobanking and realted industries, this project will accelerate the goal of personalised medicine that can eventually offer patients with fast and efficient diagnosis-treatment-healthcare system.
A LOCKING DEVICE

A linear to rotary convertor automatically assumes a locked position when controlling drive forces are terminated, the convertor employs a double acting hydraulic cylinder assembly with hydraulic fluid applied at (16 and 17) on opposite sides of a main piston in the form of a scroll cylinder shaft (18). Once the tapered locking elements are in position, hydraulic fluid to (16 and 17) is irrelevant to the continued operation of the assembly which is essentially and effectively a rigid coupling between the standard quick hitch ears (20) and pin ears (21). A locking spring disk (42) normally overcomes the unlocking spring disks (43 and 44) so that the cones (36, 37, 38 and 39) are in locking register. On application of the first drive means hydraulic fluid is delivered into the annular space illustrated at (19) to assist the springs (43 and 44) to overcome the bias of the locking spring (42) by moving unlocking piston (45) to the right thereby enabling the unlocking springs (43 and 44) to apply separating bias to release the engagement of the cone surfaces (36, 37, 38 and 39) so that application of hydraulic fluid under pressure at (16 or 17) will cause the scroll cylinder shaft (18) to rotate and thereby rotate the ears (20) to a desired position. Upon release of hydraulic pressure to the first drive means, the device will automatically revert to the locked position. A second embodiment uses a first hydraulic pressure to unlock the cones and then a second higher pressures applied to both maintain the unlocking pressure but also as a differential across the main piston to rotate the output. This provides a single joystick control where an operator selects the required angle and the unlocking and rotation actions are initiated under the single manual control.
METHOD FOR OPERATING A PROGRAM-CONTROLLED HOUSEHOLD APPLIANCE

The invention relates to a household appliance whereby the selected operating language is simple to use. The programs which can be activated take into account the special characteristics of specific languages. The household appliance comprises a display unit (4) which displays all information in a simple language. The selected language, the selected programming of the household appliance, the selected additional functions in addition to error messages are shown on the display unit so that operational mistakes are basically prevented.
A RESPIRATORY CONNECTOR ASSEMBLY AND RESPIRATORY SUPPORT SYSTEM

A respiratory support system having a flow source and a respiratory circuit. The respiratory circuit has a pressure relief valve and a tube assembly in fluid communication with the flow source and pressure relief valve. The respiratory circuit downstream of the pressure relief valve has a resistance to gas flow of 30 - 50 cmH2O at a selected gas flow rate.
3 dimensional light sensing for advanced portable devices

This proposal aims to develop 3 Dimensional Mini-cameras (producing 3D-Images) for mobile phones, tablets and laptop computers; more specifically embedded camera modules providing 2D and 3D-Images, integrating sensing electronics and optics in a single lens Wafer Level Camera (WLC).

This market creating innovative device is aiming towards disruptive market-share and global leadership in 3D-imaging camera modules, to accelerate our growth, profitability and Europe´s competitive position in smart cameras for 3D-imaging. We introduce a paradigm changer by applying new sets of rules in one of the highest growth areas addressable in consumer technologies and, we will set entry barriers that are difficult to overcome for current and new market players; we will hit the market while established competitors will still be trying to figure out our algorithms, our IPR and our hardware/software solution.

Our most disruptive competitive advantage is based on our algorithms.  These exploit a novel hardware structure described in detail in the proposal.  In short, we build micro-lenses on top of a semiconductor substrate containing image sensors or pixels with several color filters.
         
3D has captured the public imagination through Hollywood mega productions (like James Cameron´s Avatar). It has reached modest market penetration in different segments including movie productions, household 3D-TVs and cameras with two lenses.  The hurdle to mass market adoption of the technology is the lack of consistent quality 3D content. The paradigm shift that our market creating innovative 3D camera module enables is that it meets the need for much higher quality content production at a lower cost, and will enable the creation of high-quality consumer-owned 3D-content on mobile platforms. Today, 3D content creation is the privilege of a small number of professional movie makers.
Microstructure-based discrete simulations of the compaction of refractory powder composites

come from teaching and research institutions in France or abroad, or from public or private research centers.L'archive ouverte pluridisciplinaire HAL, est destinée au dépôt et à la diffusion de documents scientifiques de niveau recherche, publiés ou non, émanant des établissements d'enseignement et de recherche français ou étrangers, des laboratoires publics ou privés.
IN-PAGE INSTALLER

A method of notifying a user about the existence of relevant software and facilitating the installation of such software using a browser. A user's interactions with the browser are monitored to determine a context for a given browsing session, and it is determined whether software relevant to the context is available. If such software is available, it is recommended to the user, and if the user wishes to install the software, the installation can be performed via the browser. The software can be recommended to the user through a variety of means, including incorporating the recommendation in a static web page, incorporating the recommendation in a dynamic web page, and delivering the recommendation as part of advertising content. The recommendation may include a link to installation scripts or the like which facilitate the installation of the software by the browser.
Frequency-domain EEG source analysis for acute tonic cold pain perception

► Tonic cold pain induces significantly decreased source activity in low-frequency (<12 Hz) bands but mainly increased activity in high-frequency (>12 Hz) bands in multiple brain regions. ► Neuronal electrical activities that significantly correlated with subjective pain ratings are localized in the prefrontal and cingulate cortices. ► The findings have important implications for developing objective pain assessment methods and cortical neuromodulation based pain interventions. To investigate electrocortical responses to tonic cold pain by frequency-domain electroencephalogram (EEG) source analysis, and to identify potential electrocortical indices of acute tonic pain. Scalp EEG data were recorded from 26 healthy subjects under tonic cold pain (CP) and no-pain control (NP) conditions. EEG power spectra and the standardized low-resolution brain electromagnetic tomography (sLORETA) localized EEG cortical sources were compared between the two conditions in five frequency bands: 1–4 Hz, 4–8 Hz, 8–12 Hz, 12–18 Hz and 18–30 Hz. In line with the EEG power spectral results, the source power significantly differed between the CP and NP conditions in 8–12 Hz (CP < NP) and 18–30 Hz (CP > NP) in extensive brain regions. Besides, there were also significantly different 4–8 Hz and 12–18 Hz source activities between the two conditions. Among the significant source activities, the left medial frontal and left superior frontal 4–8 Hz activities, the anterior cingulate 8–12 Hz activity and the posterior cingulate 12–18 Hz activity showed significant negative correlations with subjective pain ratings. The brain’s perception of tonic cold pain was characterized by cortical source power changes across different frequency bands in multiple brain regions. Oscillatory activities that significantly correlated with subjective pain ratings were found in the prefrontal and cingulate regions. These findings may offer useful measures for objective pain assessment and provide a basis for pain treatment by modulation of neural oscillations at specific frequencies in specific brain regions.