SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Engineering pores for sustainable catalytic olefins upgrading

This fellowship aims at establishing the researcher as an expert in the field of heterogeneous catalysis—becoming an independent leader researcher in the EU—through interdisciplinary scientific (e.g., chemical engineering, organic and inorganic chemistry, materials and surface science) and transferable skills training (e.g., project management). The researcher, Dr. Jorge Quesada, will join the LSAC research group at UC Berkeley (USA) under the supervision of Prof. Enrique Iglesia, and will be reintegrated (EU) into the CRC research group at the Universidad de Oviedo (Spain) under the supervision of Prof. Salvador Ordóñez.
Recent findings in LSAC have demonstrated that both the catalytic stability and selectivity in the alkene dimerization on Ni-based sites are enhanced when the transition states of the elementary steps are solvated by non-polar liquids. The liquid phase is formed at the reaction temperature by capillary condensation of the solvent molecules within the pores of the material used as the active sites support. This project proposes to augment the understanding of the solvation effects on the alkene dimerization on Co-based sites—by building knowledge on their kinetic and mechanistic consequences through a mixed-methods approach—and translational research that leverages these results to other similar C-C bond forming reactions of alkenes—metathesis and hydroarylation on Mo- and Ni-based sites, respectively. This technology strategy would allow the combination of ethene dimerization and metathesis resulting in an industrial one-pot ethene-to-propene process of significant potential impact—the project engages an industrial collaborator by an intersectoral secondment. This research is likely to provide a novel versatile technology for the production of value-added olefins and related chemicals, with promising applications in the current oil industry and, especially, in future biorefineries; therefore, having a positive impact on the EU society and competitiveness.
Effects of Repeated Concentric and Eccentric Contractions on Tendon Blood Circulation

Previous studies demonstrated that treatment involving eccentric training was effective in the conservative management of chronic tendinosis. However, the mechanisms for these phenomena are unknown. The purpose of this study was to compare changes in blood circulation of the tendons after the repeated concentric and eccentric contractions. 11 healthy males volunteered for this study. Subjects performed the repeated concentric (CON) and eccentric (ECC) contractions (5 sets of 10 maximal voluntary contractions) of the plantar flexors. During and after repeated contractions, oxyhemoglobin (Oxy), deoxyhemoglobin (Deoxy), total hemoglobin (THb), and oxygen saturation (StO2) of the Achilles tendons were measured using red laser lights. Oxy and THb increased during and after ECC, but not CON. Deoxy decreased during both CON and ECC. Increase in StO2 during and after ECC was greater than that during and after CON. These results suggested that changes in blood circulation of the Achilles tendon during and after repeated eccentric contractions were more remarkable than those during and after repeated concentric contractions.
Identifying Predictors of Activity Based Anorexia Susceptibility in Diverse Genetic Rodent Populations

Animal studies are very useful in detection of early disease indicators and in unravelling the pathophysiological processes underlying core psychiatric disorder phenotypes. Early indicators are critical for preventive and efficient treatment of progressive psychiatric disorders like anorexia nervosa. Comparable to physical hyperactivity observed in anorexia nervosa patients, in the activity-based anorexia rodent model, mice and rats express paradoxical high voluntary wheel running activity levels when food restricted. Eleven inbred mouse strains and outbred Wistar WU rats were exposed to the activity-based anorexia model in search of identifying susceptibility predictors. Body weight, food intake and wheel running activity levels of each individual mouse and rat were measured. Mouse strains and rats with high wheel running activity levels during food restriction exhibited accelerated body weight loss. Linear mixed models for repeated measures analysis showed that baseline wheel running activity levels preceding the scheduled food restriction phase strongly predicted activity-based anorexia susceptibility (mice: Beta = -0.0158 (±0.003 SE), P<0.0001; rats: Beta = -0.0242 (±0.004 SE), P<0.0001) compared to other baseline parameters. These results suggest that physical activity levels play an important role in activity-based anorexia susceptibility in different rodent species with genetically diverse background. These findings support previous retrospective studies on physical activity levels in anorexia nervosa patients and indicate that pre-morbid physical activity levels could reflect an early indicator for disease severity.
The MOVE study: a study protocol for a randomised controlled trial assessing interventions to maximise attendance at physical activity facilities

Physical activity is associated with a host of health benefits, yet many individuals do not perform sufficient physical activity to realise these benefits. One approach to rectifying this situation is through modifying the built environment to make it more conducive to physical activity, such as by building walking tracks or recreational physical activity facilities. Often, however, modifications to the built environment are not connected to efforts aimed at encouraging their use. The purpose of the Monitoring and Observing the Value of Exercise (MOVE) study is to evaluate the effectiveness of two interventions designed to encourage the ongoing use of a new, multi-purpose, community-based physical activity facility.A two-year, randomised controlled trial with yearly survey points (baseline, 12 months follow-up, 24 months follow-up) will be conducted among 1,300 physically inactive adult participants aged 18-70 years. Participants will be randomly assigned to one of three groups: control, intervention 1 (attendance incentives), or intervention 2 (attendance incentives and tailored support following a model based on customer relationship management). Primary outcome measures will include facility usage, physical activity participation, mental and physical wellbeing, community connectedness, social capital, friendship, and social support. Secondary outcome measures will include stages of change for facility usage and social cognitive decision-making variables.This study will assess whether customer relationship management systems, a tool commonly used in commercial marketing settings, can encourage the ongoing use of a physical activity facility. Findings may also indicate the population segments among which the use of such systems are most effective, as well as their cost-effectiveness.Australian New Zealand Clinical Trials Registry: ACTRN12615000012572 (registered 9 January 2015).
FIGURE EIGHT MOVEMENT OF SPRAY GUN

A figure eight mechanism (12) moves a thermal spray gun (22) over a substrate (26) such that the deposit (27) pattern has a figure eight configuration. The mechanism (12) and thereby the thermal spray gun (22) and the pattern are traversed along the substrate (26). The mechanism (12) is such that, when driven by an input drive of constant speed, the deposit travels along the configuration at a non-uniform velocity. A drive system (16) provides an input drive with varying speed so as to reduce the non-uniformity of the velocity. In one aspect a motor (52) has varying speed, and in another aspect a linkage (54) between a constant speed motor (52) and the mechanism (12) provides the varying speed.
Application of Selected Quantitative Analysis Methods in the Design of an Ergonomic System

Abstract The article discusses the application of selected methods for analyzing value in the macroergonomic design of manufacturing systems for developing optimal working conditions for humans and optimal ways to utilize technical machinery and equipment. The selected value analysis method was used to assess the value of factors contributing to the occurrence of hazards at the workstations used by screw injection mold operators employed in a plastics processing company. The authors chose to focus on such positions as they pose the biggest threat to human life and health. An analysis relying on the Pareto method (ABC) helped define the optimization tasks as well as the degree of validity and mitigation of the assessed hazards. The conclusions present a model for adopting changes and improvements in the process of redesigning the macroergonomic system to create optimal working conditions in the company in question.
Impact of Artificial Intelligence on Miss Rate of Colorectal Neoplasia

Artificial intelligence (AI) may detect colorectal polyps that have been missed due to perceptual pitfalls. By reducing such miss rate, AI may increase the detection of colorectal neoplasia leading to a higher degree of colorectal cancer (CRC) prevention.Patients undergoing CRC screening or surveillance were enrolled in 8 centers (Italy, UK, US), and randomized (1:1) to undergo 2 same-day, back-to-back colonoscopies with or without AI (deep learning computer aided diagnosis endoscopy) in 2 different arms, namely AI followed by colonoscopy without AI or vice-versa. Adenoma miss rate (AMR) was calculated as the number of histologically verified lesions detected at second colonoscopy divided by the total number of lesions detected at first and second colonoscopy. Mean number of lesions detected in the second colonoscopy and proportion of false negative subjects (no lesion at first colonoscopy and at least 1 at second) were calculated. Odds ratios (ORs) and 95% confidence intervals (CIs) were adjusted by endoscopist, age, sex, and indication for colonoscopy. Adverse events were also measured.A total of 230 subjects (116 AI first, 114 standard colonoscopy first) were included in the study analysis. AMR was 15.5% (38 of 246) and 32.4% (80 of 247) in the arm with AI and non-AI colonoscopy first, respectively (adjusted OR, 0.38; 95% CI, 0.23-0.62). In detail, AMR was lower for AI first for the ≤5 mm (15.9% vs 35.8%; OR, 0.34; 95% CI, 0.21-0.55) and nonpolypoid lesions (16.8% vs 45.8%; OR, 0.24; 95% CI, 0.13-0.43), and it was lower both in the proximal (18.3% vs 32.5%; OR, 0.46; 95% CI, 0.26-0.78) and distal colon (10.8% vs 32.1%; OR, 0.25; 95% CI, 0.11-0.57). Mean number of adenomas at second colonoscopy was lower in the AI-first group as compared with non-AI colonoscopy first (0.33 ± 0.63 vs 0.70 ± 0.97, P < .001). False negative rates were 6.8% (3 of 44 patients) and 29.6% (13 of 44) in the AI and non-AI first arms, respectively (OR, 0.17; 95% CI, 0.05-0.67). No difference in the rate of adverse events was found between the 2 groups.AI resulted in an approximately 2-fold reduction in miss rate of colorectal neoplasia, supporting AI-benefit in reducing perceptual errors for small and subtle lesions at standard colonoscopy.gov, Number: NCT03954548.
MED Sha.p.e.s. Sharing prior excellence and support for the MED creative asset

Shapes is focused on the excellences of the Knowledge/Creative Economy in the MEDarea. In this area are concentrated in fact the most appreciated talents/brands/know-hows worldwide. The creative asset directly or indirectly produces cultural products and includes not only commercial/production/service enterprises but also artists, public and non-profit organizations. For this reason Shapes is also dealing with the governance theme. In fact the so-called creative cluster cuts across multiple economic and institutional sectors and competences and does not constitute a cohesive sector in the traditional sense of a productive cluster. For Shapes, we have defined a double target: 1. public relevance: institutions, and social parts 2. private relevance: economic actors, categorized in 3 broad groups: - Arts and Culture - Design - Media In all these sectors and in decision-making processes, the partnership implements actions of: knowledge /technology sharing and capacity and awareness rise. Sha.p.e.s. capitalizes tools, experiences, models and results of 10 projects (ended or still on going) dealing with innovation and creativity and their governance. Shapes intends further to: - create a common toolbox of all available online tools running in a Sha.p.e.s. Resource Centre. - share and transfer consolidated methodologies and services as innovation drivers - create a common operating model for assessing territorial innovation potential and for boosting the promotion of innovation policies and creative businesses. The 13 partners of this project come from: Italy, Spain, Greece, Portugal, Slovenia, France. It is a multilevel partnership. In fact the participating organizations are representing the business service providers, the public authorities and their associations, the research and academic centres. This variety of subjects assures the project's sustainability because the creative and innovative process is fed by the mutual interest in collaborating of active regional actors.
Nivolumab versus sorafenib in advanced hepatocellular carcinoma (CheckMate 459): a randomised, multicentre, open-label, phase 3 trial

Single-agent nivolumab showed durable responses, manageable safety, and promising survival in patients with advanced hepatocellular carcinoma in the phase 1-2 CheckMate 040 study. We aimed to investigate nivolumab monotherapy compared with sorafenib monotherapy in the first-line setting for patients with advanced hepatocellular carcinoma.In this randomised, open-label, phase 3 trial done at medical centres across 22 countries and territories in Asia, Australasia, Europe, and North America, patients at least 18 years old with histologically confirmed advanced hepatocellular carcinoma not eligible for, or whose disease had progressed after, surgery or locoregional treatment; with no previous systemic therapy for hepatocellular carcinoma, with Child-Pugh class A and Eastern Cooperative Oncology Group performance status score of 0 or 1, and regardless of viral hepatitis status were randomly assigned (1:1) via an interactive voice response system to receive nivolumab (240 mg intravenously every 2 weeks) or sorafenib (400 mg orally twice daily) until disease progression or unacceptable toxicity. The primary endpoint was overall survival assessed in the intention-to-treat population. Safety was assessed in all patients who received at least one dose of study drug. This completed trial is registered with ClinicalTrials.gov, NCT02576509.Between Jan 11, 2016, and May 24, 2017, 743 patients were randomly assigned to treatment (nivolumab, n=371; sorafenib, n=372). At the primary analysis, the median follow-up for overall survival was 15·2 months (IQR 5·7-28·0) for the nivolumab group and 13·4 months (5·7-25·9) in the sorafenib group. Median overall survival was 16·4 months (95% CI 13·9-18·4) with nivolumab and 14·7 months (11·9-17·2) with sorafenib (hazard ratio 0·85 [95% CI 0·72-1·02]; p=0·075; minimum follow-up 22·8 months); the protocol-defined significance level of p=0·0419 was not reached. The most common grade 3 or worse treatment-related adverse events were palmar-plantar erythrodysaesthesia (1 [<1%] of 367 patients in the nivolumab group vs 52 [14%] of patients in the sorafenib group), aspartate aminotransferase increase (22 [6%] vs 13 [4%]), and hypertension (0 vs 26 [7%]). Serious treatment-related adverse events were reported in 43 (12%) patients receiving nivolumab and 39 (11%) patients receiving sorafenib. Four deaths in the nivolumab group and one death in the sorafenib group were assessed as treatment related.First-line nivolumab treatment did not significantly improve overall survival compared with sorafenib, but clinical activity and a favourable safety profile were observed in patients with advanced hepatocellular carcinoma. Thus, nivolumab might be considered a therapeutic option for patients in whom tyrosine kinase inhibitors and antiangiogenic drugs are contraindicated or have substantial risks.Bristol Myers Squibb in collaboration with Ono Pharmaceutical.
GROUP NAME S.R.L.

THE PICK-UP PROJECT WILL IMPLEMENT AND VALIDATE INNOVATIVE, OPEN AND SCALABLE METHODS AND TOOLS FOR ENERGY AND ENVIRONMENTAL MANAGEMENT AND REDUCTION OF CONSUMPTION IN HETEROGENEOUS URBAN DISTRICTS, INTEGRATING: IOT SENSOR NETWORKS AND FOG COMPUTING; NEW METHODOLOGIES FOR MODELLING AND ANALYSIS OF ENERGY DATA AND PREDICTIVE CONTROL; INNOVATIVE MODELS FOR AGGREGATION AND INTEGRATION OF DISTRIBUTED POWER GENERATION AND DEMAND SOURCES (DEMAND RESPONSE, SMART MICROGRID).
An EGF-based methodology for predicting compatible seismograms in the spectral domain using GA technique

SUMMARY

The main objective of this paper is to present a methodology for predicting spectrum compatible seismograms at sites where main shock is not recorded by other sites from which the main event has been observed using recorded aftershocks. The genetic algorithm and multitaper method are employed to minimize differences between the calculated synthetic seismogram and observed data. The multitaper spectrum approach being used permits the reduction of spectral leakage providing the possibility of matching the Fourier spectral amplitudes corresponding to synthetic and observed waveforms. The proposed technique is applied to the 2006 Silakhor earthquake (Mw= 6.1, Iran) as a case study. The six component waveforms (L, T and V) at two stations were simulated by minimizing errors between the synthetic response spectra, the Fourier spectral amplitudes and those of the observed. The results are shown to be in a good agreement with those of the observed data.



The three components of waveforms at the other three stations were predicted incorporating the calculated parameters. The validity of the technique is proven through demonstrating good agreement of the response spectra and Fourier spectral amplitudes corresponding to the predicted and observed seismograms at other three stations. It is concluded that, the methodology is applicable for predicting realistic acceleration time histories to be used in seismic performance evaluation of existing structures in the region under study.
Biomedical Techniques in Context: On the Appropriation of Biomedical Procedures and Artifacts

On the assumption that technical practices and artifacts are fundamental constituents of individual and collective attempts to order lives and bodies in health and sickness, in this introduction, we set out three central propositions. First, medical techniques have to take center stage in research on biomedicine. Second, as medical artifacts travel worldwide, they become part of the processes of sociocultural appropriation. Third, anthropologists have to consider how to study the transformations associated with such appropriation and how much they need to know about the technical aspects of their objects of study. The mutual transformative potential of both biomedical artifacts and practices and the new contexts of application have so far been undertheorized in medical anthropology--a gap that we aim to close with our reflections and the collection of empirical studies of various biomedical techniques in this issue.
MAINTENANCE ALERT SYSTEM FOR HEAVY-DUTY TRUCKS

A real-time maintenance alert system for use in a heavy duty truck having an engine including an engine controller having a communications data link is provided. The system includes an engine item sensor and a non-engine item sensor. Control logic at the engine controller produces an output signal at the data link in response to the presence of an engine item real-time fault condition. A display device transmits and receives information over the data link, and processes the control logic output signal. The display device generates an output signal indicative of the engine item status. Further, the display device directly receives and processes the non-engine item sensor output signal, and generates an output signal indicative of the non-engine item status.
An Energy-Efficient Concurrency Control Algorithm for Mobile Ad-Hoc Network Databases

MANET does not require any fixed infrastructure, thus it fits well in disaster rescue and military operations. However, when a node has no or insufficient energy to function, communication may fail, disconnections may happen, and transactions may be aborted if they are time-critical and miss their deadlines. Energy-efficient transaction management becomes an important issue in MANET database applications. In this paper, we propose an energyefficient concurrency control (CC) algorithm for MANET databases in a clustered network architecture where nodes are divided into clusters, each of which has a node, called cluster head, responsible for the processing of all nodes in the cluster. In our algorithm, in order to conserve energy and balance the energy consumption among servers, we elect cluster heads to work as coordinating servers, and propose an optimistic CC algorithm to offer high concurrency and avoid wasting limited system resources. The simulation results confirm that our technique performs better than existing techniques.
ON THE WAY... OF THE ABBEY

THE PROJECT FORESEES THE RENOVATION OF A BUILDING FOR LIMPLEMENTATION OF TOURIST ACCOMMODATION IN AN AREA OF ENVIRONMENTAL AND NATURALISTIC VALUE; THE BUILDING IS PART OF A VAST PROPERTY THAT INCLUDES A HOTEL WITH RESTAURANT-BAR (HOTEL RESTAURANT CONCA AZZURRA). THE BUILDING IS LOCATED 50 METERS FROM THE ALBERGO AND WILL THEREFORE BE MANAGED UNDER A SINGLE DIRECTION (HOTEL DIFFUSE).LIMMOBILE Š LOCATED IN THE HAMLET OF OLGIASCA, PANORAMIC PENINSULA KNOWN FOR THE PRESENCE OF PIONA, FAMOUS CISTERCIAN ABBEY, FROM WHICH LÂALBERGO IS 1 KM AWAY. THIS ABBEY IS ONE OF THE TOURIST PECULIARITIES OF COLICO, VISITED ANNUALLY BY NATIONAL AND INTERNATIONAL TOURISTS WHO REACH THE STRUCTURE BY LAND BY CAR OR TRAIL OR BY LAKE (BOAT OR TAXIBUS). ÂTHE ARCHITECTURAL COMPLEX CONSTITUTING THE PRIORY OF PIONA, GENERALLY KNOWN AS THE ABBEY OF PIONA, IS LOCATED ON THE BANKS OF LAKE COMO IN THE TERRITORY OF CO
Not all that's new and shiny is good for healthcare

Concern has been growing about the use of metal on metal hip implants. In its 2011 report, the National Joint Registry for England and Wales identified problems including higher revision rates compared with more traditional ceramic or polyethylene implants ( BMJ 2011;343:d5977). A BMJ investigation by Deborah Cohen asked why it took so long for one metal on metal implant, the ASR, to be withdrawn, highlighting denials and delays by the manufacturer and failings in the regulation of medical devices ( BMJ 2011;342:d2905).

This week we publish a systematic review of research into the safety and effectiveness of hip implants. Art Sedrakyan and colleagues conclude that the evidence is inadequate, but what …