SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Tibetan Plateau westerly forcing on the cloud amount over Sichuan Basin and the early Asian summer monsoon

[1] Data show that a sizeable mechanical effect of the Tibetan Plateau (TP) on the westerly, referred to as TP westerly forcing, is related to a sizeable midlevel cloud amount over Sichuan Basin (SB; centered near 30°N and 105°E) to the east of the TP. An investigation of the interannual variability of clouds over SB demonstrated that the TP westerly forcing closely correlates to the early Asian summer monsoon (ASM). When the monsoon commences in mid-May, the East Asian upper tropospheric jet stream moves northward with a southwest-northeast tilt; the tilt of the jet considerably influences the TP westerly forcing. Because of the stationary wave pattern superimposed on the westerly jet, the early ASM is substantially distinct by year. In the years the midlevel cloud amount in SB is sizeable (which corresponds to a strong TP westerly forcing), the tilt of the upper level jet increases, and the ascending southerly east of SB in 110°E–125°E strengthens. The warming of the troposphere in 110°E–125°E centered near 35°N corresponds to the westerly and southerly changes. Farther downstream in the 125°E–140°E region, the ascending southerly weakens. Correspondingly, an anomalous anticyclonic circulation occurs between SB and Japan, leading to a westward extension of the North Pacific high pressure in the lower troposphere and a reduction in precipitation of the early Mei-Yu season. Coincidentally, the midtropospheric monsoon trough south of the TP weakens, implying a weak monsoon in both East Asia and South Asia. Furthermore, the weak monsoon continues through the early summer.
Exploring social innovation approaches for the social and economic integration of non-EU nationals

The overall objective of the project is to enhance the capacities of decision-makers in nine rural areas previously subject to declining and ageing populations to successfully integrate young non-EU nationals into social life and employment to stabilise their demography. To that aim, approaches based on social innovation shall be introduced, refitted to respond to the specific characteristics of rural areas, tested and assessed whether they are capable to lead to the desired results. A tool-box of possible approaches shall be provided to local decision-makers, accompanied by trainings. Furthermore, the project also aims to change the foremost negative perspective on migration of non-EU nationals to one where its potentials are seen and actively explored.

Partners in ARRIVAL REGIONS will first exchange their experiences and explore approaches of social innovation that appear to be successful elsewhere. Together with the scientific partners involved in the project, the identified good practices will be reshaped to prepare their implementation in rural areas with a shrinking “native” population. For a period of 12 to 18 months, nine novel approaches will be piloted in Central European areas. Their effectiveness will be evaluated both through quantitative indicators and stakeholder workshops (qualitative criteria) to determine their success. Seminars and other capacity building measures are implemented in parallel together with stakeholders. Those which have delivered the desired results become subject of a tool-box which helps a larger number of public authorities to apprehend and unleash the potentials of inward migration of non-EU nationals.

The project’s outputs are a tool-box for public authorities composed by successfully tested approaches to spur the integration of non-EU nationals in rural areas, a pilot project carried out in each addressed territory and a series of trainings focussing on the established social innovation-based approaches.
Rehabilitation and Development in Mining Regions

Large-scale environmental problems and difficulties in urban development are a barrier to structural change throughout the mining regions of CADSES. In many cases a monostructured economy, the prevalence of paternalistic structures, a negative image and the persistence of environmental damage with remaining risk elements require an integrated approach to rehabilitate and develop mining regions. The structural change in mining regions is a difficult task and many small or mid-sized cities, particularly in peripheral regions, are not able to cope with it alone. READY aims at strengthening the competitive ability of mining cities and mining regions in Central and Eastern Europe by improving their ecological, social and economic situation. The project addresses major planning and development issues with special consideration of the situation in Austria, Bulgaria, the Czech Republic, Germany, Italy, Romania and Slovakia. In the 18 mining cities and regions participating in the project, the mining industry is in decline or mining and manufacturing of mining products have already been ceased. The main objectives of the project are to provide incentives for structural changes in former mining cities and regions by accomplishing new development perspectives and the initiation of a new quality of transnational co-operation by establishing a high-performance network. Co-ordinated actions should increase political awareness of disadvantaged mining cities and regions. READY includes four types of activities: local activities in the participating cities, intensive international networking, the founding of a European network of mining cities and support for local implementation of strategies and measures.
Cholesterol and sugar uptake mechanisms

Cardiovascular disease, diabetes and cancer have a dramatic impact on modern society, and in great part are related to uptake of cholesterol and sugar. We still know surprisingly little about the molecular details of the processes that goes on in this essential part of human basic metabolism. This application addresses cholesterol and sugar transport and aim to elucidate the molecular mechanism of cholesterol and sugar uptake in humans. It moves the frontiers of the field by shifting the focus to in vitro work allowing hitherto untried structural and biochemical experiments to be performed.
Cholesterol uptake from the intestine is mediated by the membrane protein NPC1L1. Despite extensive research, the molecular mechanism of NPC1L1-dependent cholesterol uptake still remains largely unknown. 
Facilitated sugar transport in humans is made possible by sugar transporters called GLUTs and SWEETs, and every cell possesses these sugar transport systems. For all these uptake systems structural information is sorely lacking to address important mechanistic questions to help elucidate their molecular mechanism.
I will address this using a complementary set of methods founded in macromolecular crystallography and electron microscopy to determine the 3-dimensional structures of key players in these uptake systems. My unpublished preliminary results have established the feasibility of this approach. This will be followed up by biochemical characterization of the molecular mechanism in vitro and in silico.
This high risk/high reward membrane protein proposal could lead to a breakthrough in how we approach human biochemical pathways that are linked to trans-membrane transport. An improved understanding of cholesterol and sugar homeostasis has tremendous potential for improving general public health, and furthermore this proposal will help to uncover general principles of endocytotic uptake and facilitated diffusion systems at the molecular level.
Dsense – self adapting, cost efficient method for detecting context of a mobile device  and a mobile device with a context detection module

The project is going to launch in existing mobile devices a software system and/or module for a context detection to ensure environmentally and costly efficient required service’s results for users. The R&D Department of Binartech has developed basic substantial assumptions of these method,it is protected by international patent in Poland, Europe (Germany, France,UK),Japan, U.S.A. India (patent pending).
The disruptive solution focuses on more effective,faster and apt fit of mobile services to user's needs, which is possible thanks to a device being aware of a broader context in which it is used atm (eg. when driving a car or walking). Our solutions provides much better compromise between accuracy and energy usage. dSense is distinctive from available solutions because of its self-adapting skills, which are crucial due to large variety of devices and environments people use their mobile phones. This means that even for ca. 5% user of mobile devices having every-day problems with accuracy of context awareness of mobile applications, it will be easy to get self-learning correct results in a short period of time using low energy-consuming sensors.
We have identified three areas of benefits according to understanding of the user, i.e.: final users of mobile devices,application developers/investors, and mobile devices producers which mount the module in their devices.Added values are:operating time of the battery (better up to 60%), automatic adaptation of the context detection system to all applications being installed to the mobile devices, accuracy of applications’ results and speed of delivered applications’ results. 
Feasibility study will enable us to verify the technological feasibility and economic viability of launching dSense on EU’s market, which will contribute to solving the aforementioned problems.PHASE I is the beginning and we believe it will lead to PHASE II.This will enable us to identify resources needed for commercial implementation of our technology.
Investigation on the variation of shale permeability with spontaneous imbibition time: Sandstones and volcanic rocks as comparative study

Abstract The development of gas shale needs a large scale of hydraulic fracturing during the process of well completion. However, the rate of flow-back is always less than the half of the injected fluid. Thus, a large number of fracturing fluid becomes retention in the shale reservoir and aqueous phase trapping (APT) appears. APT appears after well drilling, completion, work over and stimulation operation, caused by fluid filtrating into formation and resulting in permeability reduction. However, after the well was shut in for a period of time in shale gas development, the APT can be auto-removed. In order to investigate the auto-removal mechanism of shale reservoirs, related experiments were performed. In this paper, we used pulse-decay permeability method to monitor the permeability change of shale rocks during the process of shale rocks spontaneous imbibition. At the same time, the sandstones and volcanic rocks did as control samples. From the experiments, the permeability of sandstones and volcanic rocks decreases with increasing imbibition time, and there are no cracks produced in the process of imbibition of these two kinds of samples. However, during the process of shale rocks imbibition, cracks appear on the surface of samples, which may be caused by clay swelling. Simultaneously, the permeability of shale rocks fluctuates apparently. Some shale samples even have the specific interval that the permeability increases with soaking liquid time. This specific phenomenon may be caused by the new produced cracks, which increases the pore volume. Because the matrix of shale has the characteristic of hydrophobicity, much of the new pores couldn't be occupied by the liquid under the effect of spontaneous imbibition. Thus, the gas flowing channels tremendously increase. However, the stress sensitivity can lead to shale permeability decrease, which impacts the variation of permeability under certain confining pressure. These findings contribute to better understanding the shale APT auto-removal after hydraulic fracturing.
Next-Generation antibody-drug conjugates for safer and more effective cancer therapies

Oncolinx has developed a novel molecular platform allowing for non-invasive and highly effective cancer cures. The platform carries a killing drug (Azonafide), linked to an antibody, specifically targeting and destroying only malignant tumour cells. These molecular complexes are called Antibody Drug Conjugates (ADCs) and represent a strong, valid alternative to current chemotherapies. Oncolinx’s innovative linker/payload technology enables the Azonafide platform to perform a sensitive discrimination between healthy and cancer cells, thereby avoiding adverse side-effects of chemotherapy. ADCs enhance the effectiveness of a systemic treatment and have the advantage of targeting only tumour sites within the same therapy. Oncolinx’s drugs are effective against drug resistant cancers, as well as cancer stem cells (CSCs)—cells directly responsible for drug-resistance, metastasis, and relapse. In addition, Oncolinx’s technology activates the immune system against the tumour, which is an integral hallmark of durable responses. Although Oncolinx’s platform is designed to be adopted for drug-resistant breast cancers as first application, the Azonafide payload potency has been validated across all NCI-60 cell lines screening for different tumour types. The NCI-60 Human Tumour Cell Lines Screen also showed that the Azonafide payload, when conjugated with Oncolinx linker technology to specific antibodies, can kill up to 98.2% of cancer cells while remaining non-toxic to cells that do not express the antigen. NCI-60 screening has shown subnanomolar-picomolar potency across cancers  (1x10-9M). While a variety of ADCs compound are currently developed and tested, only two ADCs have been approved so far. However, because Azonafide platform has a unique mechanism of action, Oncolinx can exclusively target slow growing cancers, drug resistant cancers, and other cancers that cannot be treated by the technologies of the two competitors (Seattle Genetics and ImmunoGen).
The Talk of the Town: Kit Manufacturers Negotiate the Building Industry, 1905-1929

Urban historical scholars have neglected smaller urban centers, including their residential environments and the forces that shaped them. For a time, one of these forces was the mail-order kit home. Kit manufacturers sold houses to families throughout the United States and Canada but enjoyed their greatest success in small towns where detached single-family homes were the norm. They worked to insert themselves into local building industries: They challenged lumber dealers and ignored architects but strove to mollify the contractors on whom they and their customers depended. They attracted considerable attention and met with initial success: Emerging rapidly after 1905, they had hit their stride by 1914 and enjoyed a heyday in the 1920s. They were stricken by, and failed to recover from, the Depression in large part because lumber dealers had learned how to compete with them.
Octopus: oncological concurrent tomographic optoacoustics, pet and ultrasonography.

Cancer is the second leading cause of death globally. Noninvasive imaging of tumor hallmarks helps to combat cancer more efficiently. However, cancer is a complex disease and modern imaging of cancer should evolve to help exploring the interaction between different cancer hallmarks and to predict the evolution of some of them in relation to others. Besides, these new techniques should provide answers to the present unmet need for determining, precisely, how, which and when targeted therapeutic agents can be used for optimized efficacy. In this project we will build a new hybrid cancer imaging device: OCTOPUS (Oncological Concurrent Tomographic Optoacoustics, PET and UltraSonography), that will pioneer the intersection of molecular, vascular and tissue oxygenation information, three major hallmarks of cancer. OCTOPUS is a timely action to study tumor dynamics with a hybrid hallmark perspective in a longitudinal, simultaneous, quantitative, fully co-registered and in vivo manner. To reach this goal, I will develop cutting-edges technologies regarding multispectral tomographic optoacoustic using an arrangement of 3D ultrasound arrays, combined with actual 3D sequences of Ultrafast Ultrasound and a custom-made PET system for data acquisition and reconstruction. A deep learning framework will be created for advanced multiparametric analysis of OCTOPUS derived data to facilitate the interpretation of intra-tumoral processes in order to improve high-precision image-guided treatment and ultimately to guide in the design of targeted therapies.
An exploration of two therapeutic approaches to dramatherapy and the use of myth enactment to mediate a change in behaviour

This dissertation aims to explore the uses of dramatherapy, and specifically examine if using mythological stories within the dramatherapeutic environment elicits a positive change regarding the behaviour of clients. The initial research will look into dramatherapy and myth separately, exploring their origins and inspecting the social conditions which continue to incorporate myth into contemporary culture, and allow dramatic techniques to exist as a form of therapy. In this dissertation, the investigation will concern two different approaches to dramatherapy, the Sesame Approach and the Gestalt psychotherapy approach. These two approaches originate from different theoretic backgrounds, which influence their individual methodologies; the Sesame Approach basing their approach on the theory of Active Imagination by Carl Jung, and the Gestalt approach utilising key aspects of phenomenology, developed by Fritz Perls; Jenny Pearson and Paul Rebillot are the two practitioners whose case studies will be explored for evidence of behavioural change in clients, with both dramatherapists using scripts of mythology. This dissertation will also comment upon aspects of Freud, specifically, his theories on the use of analysing myth as a method for psychoanalysis. This study aims to inform the reader on this exciting, evolving therapy which utilises dramatic techniques, and to explore if healing powers of theatre naturally exist.
Prospective of Medical Cost for Genitourinary Cancer for Sex and Age Group in Range 2012-2050: Case of Mexico

Medical costs are calculated for genitourinary cancer for all age groups of Mexican people and sex into range of 2012-2050. Probabilities of entrance or disease detection, permanence or in treatment and departure or death are calculated for each age group and sex. The maximum probabilities for each case are 0.038% (65+), 0.376%-0.388% (25-29, 85+) and 0.6438% (85+), for male. Analogously, for female are 0.0201% (60-64), 0.514% (35-39), and 0.1074% (85+), respectively. The treatment medical costs are not similarly between men and women. The maximum number of people in treatment is in (20-29) for male and (35-39) for female. The number of patients decreasing in the range. The unit costs are bigger for patients of 50 years old and more than all age group for male (+7.02%) whereas it is not for female.
5G for cooperative & connected automated mobiility on x-border corridors

5G-MOBIX aims at executing CCAM trials along x-border and urban corridors using 5G core technological innovations to qualify the 5G infrastructure and evaluate its benefits in the CCAM context as well as defining deployment scenarios and identifying and responding to standardisation and spectrum gaps.
5G-MOBIX will first define the critical scenarios needing advanced connectivity provided by 5G, and the required features to enable those advanced CCAM use cases. The matching between the advanced CCAM use cases and the expected benefit of 5G will be tested during trials on 5G corridors in different EU countries as well as China and Korea.
Those trials will allow running evaluation and impact assessments and defining also business impacts and cost/benefit analysis. As a result of these evaluations and also internation consultations with the public and industry stakeholders, 5G-MOBIX will propose views for new business opportunity for the 5G enabled CCAM and recommendations and options for the deployment.
Also the 5G-MOBIX finding in term of technical requirements and operational conditions will allow to actively contribute to the standardisation and spectrum allocation activities.
5G-MOBIX will evaluate several CCAM use cases, advanced thanks to 5G next generation of Mobile Networks. Among the possible scenarios to be evaluated with the 5G technologies, 5G-MOBIX has raised the potential benefit of 5G with low reliable latency communication, enhanced mobile broadband, massive machine type communication and network slicing.
Several automated mobility use cases are potential candidates to benefit and even more be enabled by the advanced features and performance of the 5G technologies, as for instance, but not limited to: cooperative overtake, highway lane merging, truck platooning, valet parking, urban environment driving, road user detection, vehicle remote control, see through, HD map update, media & entertainment.
A compact DD neutron generator–based NAA system to quantify manganese (Mn) in bonein vivo

A deuterium-deuterium (DD) neutron generator-based neutron activation analysis (NAA) system has been developed to quantify metals, including manganese (Mn), in bone in vivo. A DD neutron generator with a flux of up to 3*10(9) neutrons s(-1) was set up in our lab for this purpose. Optimized settings, including moderator, reflector, and shielding material and thickness, were selected based on Monte Carlo (MC) simulations conducted in our previous work. Hand phantoms doped with different Mn concentrations were irradiated using the optimized DD neutron generator irradiation system. The Mn characteristic γ-rays were collected by an HPGe detector system with 100% relative efficiency. The calibration line of the Mn/calcium (Ca) count ratio versus bone Mn concentration was obtained (R(2) = 0.99) using the hand phantoms. The detection limit (DL) was calculated to be about 1.05 μg g(-1) dry bone (ppm) with an equivalent dose of 85.4 mSv to the hand. The DL can be reduced to 0.74 ppm by using two 100% HPGe detectors. The whole body effective dose delivered to the irradiated subject was calculated to be about 17 μSv. Given the average normal bone Mn concentration of 1 ppm in the general population, this system is promising for in vivo bone Mn quantification in humans.
LEIRIARTEM HOTEL — Hotel 4* y Centro de Conferencias

HOTEL LEIRIARTEM: creación de un nuevo establecimiento, un hotel 4* en Leiria dedicado al segmento corporativo, que combina alojamiento y centro de conferencias con cultura, ocio, deporte y bienestar.