SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Empowering a reduction in use of conventionally fueled vehicles using positive policy measures.

The main objective of EMPOWER is to substantially reduce the use of conventionally fueled vehicles (CFV) in cities by influencing the mobility behaviour of CFV drivers and users towards fundamental change. To achieve this objective EMPOWER will create a set of tools for industry, policy makers and employers. These will empower them beyond the lifespan of this project to understand, help choose and successfully implement ‘positive’ evidence-based and cost-effective policy interventions, based on new and innovative mobility services, and in the context of already existing infrastructure, policy and measures. EMPOWER will reduce the use of CFV by: shifting trips to other modes/other vehicle types, promoting sharing and self-organisation and reducing demand overall e.g. through remote access to services. Undesirable impacts from CFV use will be reduced by: shifting CFV use to outside peak times and diversions to avoid particular areas/routes. The research will be multidisciplinary and involve: social science research with the public, 4 living lab experiments and 7 City demonstrators which will be chosen through an open 'bidding' process. The EMPOWER concept will be used in practice by: City stakeholders being able (through a software tool) to choose positive policy options based on their expected impacts and deliver incentives and social network sharing schemes to individuals using software. The innovation outputs of EMPOWER include an EMPOWER Toolkit to support industry, policy makers and employers to understand, choose and implement positive policy interventions. The Toolkit includes: new mobility services to provide innovative positive policy measures, new evidence on behavioural responses and impacts from positive incentives, improved organisational models for successful implementation of positive policy measures and innovation in the evaluation methodology for new mobility services. We expect at least 1 million persons to be impacted by EMPOWER.
How complement molecules kill bacteria

This proposal aims to provide insight into how bacteria are killed by the complement system, an important part of the host immune response against bacterial infections. Complement is a large protein network in plasma that labels bacteria for phagocytosis and directly kills them via the formation of a pore-forming complex (Membrane Attack Complex (MAC)). Currently we do not understand how complement activation results in bacterial killing. This knowledge gap is mainly caused by the lack of tools to study the enzymes that trigger MAC formation: the C5 convertases. 

In my lab, we recently established a novel assay system for C5 convertases that allows us for the first time to study these enzymes under purified conditions. This model, combined with my expertise in microbiology, places my lab in a unique position to understand C5 convertase biology (Aim 1), determine the enzyme's role in MAC functioning (Aim 2) and elucidate how the MAC kills bacteria (Aim 3). Thus, I aim to provide insight into the molecular events necessary for bacterial killing by the complement system.

I will use biochemical, structural and microbiological approaches to elucidate the precise molecular arrangement of C5 convertases in vitro and on bacterial cells. I will generate unique tools to study how C5 convertases regulate MAC insertion into bacterial membranes. Finally, I will engineer fluorescent bacteria and labeled complement proteins to perform advanced microscopy analyses of how MAC kills bacteria. 

These insights will lead to fundamental knowledge about the functioning of complement and will create new avenues for blocking the undesired complement activation during systemic infections and acute inflammatory processes. Furthermore this knowledge will improve desired complement activation by therapeutic antibodies and vaccination strategies in infectious diseases. Finally, this work opens up new possibilities to understand how both humans and bacteria regulate complement.
Algal lipids: the key to earth now and ancient earth

Alkenones are algal lipids that have been used for decades to reconstruct quantitative past sea surface temperature. Although alkenones are being discovered in an increasing number of lake sites worldwide, only two terrestrial temperature records have been reconstructed so far. The development of this research field is limited by the lack of interdisciplinary research that combines modern biological and ecological algal research with the organic geochemical techniques needed to develop a quantitative biomarker (or molecular fossil) for past lake temperatures. More research is needed for alkenones to become a widely used tool for reconstructing past terrestrial temperature change. The early career Principal Investigator has discovered a new lake alkenone-producing species of haptophyte algae that produces alkenones in high abundances both in the environment and in laboratory cultures. This makes the new species an ideal organism for developing a culture-based temperature calibration and exploring other potential environmental controls. In this project, alkenone production will be manipulated, and monitored using state-of-the-art photobioreactors with real-time detectors for cell density, light, and temperature. The latest algal culture and isolation techniques that are used in microalgal biofuel development will be applied to developing the lake temperature proxy. The objectives will be achieved through the analysis of 90 new Canadian lakes to develop a core-top temperature calibration across a large latitudinal and temperature gradient (Δ latitude = 5°, Δ spring surface temperature = 9°C). The results will be used to assess how regional palaeo-temperature (Uk37), palaeo-moisture (δDwax) and palaeo-evaporation (δDalgal) respond during times of past global warmth (e.g., Medieval Warm Period, 900-1200 AD) to find an accurate analogue for assessing future drought risk in the interior of Canada.
Ecologic smart system for housing and innovative electronic large defence

Standard solutions for electronic components housing need power-consuming cooling devices to keep the internal operative
temperature. An air-conditioner requires space, additional costs for transportation and high power consumption. Motulab Srl
will provide the market with a Modular Smart Frame (MSF), that is a shelter based on passive insulation and built with an
innovative combination of elements opportunely designed to maintain the internal temperature with reduced (or even
without) conditioning systems; part of them is a panel made of recycled plastic, heritage of Motulab former participation to
the CIP EU funding scheme.
The MSF can address Microwave stations, Satellite communication - Earth stations, Base repeater stations (BTS), Power
stations, Switching stations, Gas & Oil pipelines SCADA station, Railways, Computer rooms. In Italy alone, BTS annual
consumption approaches 2.1 TWh/year, namely 0.6 % of total national electrical consumption (source TERNA): a huge
number corresponding to 1.2 Mtons of equivalent CO2: the minimum power consumption saving will be 25/30%.
From the financial point of view a preliminary analysis has been done, revealing a real possibility to boost the company’s
turnover by 600%. The main targets for the business are the EU’s telecommunications and ICT infrastructures sectors. A
specialized company for commercialization has been engaged in 2015, to share a portafolio of huge users like Telecom Spa
(major Italian telecommunication company) and Trenitalia (major Italian railway company).
MEASURING SYSTEM FOR ACTUAL ENERGY CONSUMPTION OF CENTRAL HEATING RADIATORS

A system for measuring the actual energy consumption of each individual radiator in central heating installations, wherein the energy consumption of a single radiator is measured in real and actual units of heat Kw/h by a digital control unit (4) for data processing, connected by means of an electric cable (3) to a metal part, where a flowmeter and temperature sensor (1 ) are installed at the radiator outlet and connected by means of an electric cable (5) to a metal ring with a temperature sensor (7) installed at the radiator outlet, and the digital control unit consists of a module in the form of an electric appliance (4) and data which is the data of real used Kcals or Kw/h by a central heating radiator in certain operating time and identification number of the device will be stored in the memory of the device until read by radio connection (9); transmitted to a collective device according to the settings, a device for collective reading and data transmission (8). Preferably a mechanical flowmeter (1 ) is equipped with rotating vanes (1 d) from which impulses are recorded by an electronic recording device (1f) and a temperature probe (1 g) measuring the temperature of the liquid outflow from a radiator. The electronic device (4) contains an electronic digital systems module (4a) with a program for processing data into the actual heat consumption data of a radiator, powered by a battery (4b). The internal flowmeter rim (1 e) has a diameter adapted to the internal diameter of the valve (2b) and a rubber or plastic gasket (1 c) applied on the rim (1 e), which, together with the radiator union, guarantees a tight connection. The system can be installed horizontally or vertically without loss or alteration of data, it can be mounted absolutely on every central heating radiator without limits of what material the radiator is made of, of what the power is or where it is located in a given room and also without the need to enter additional technical data of the radiator into the software in the data receiver.
The London Mechanics' Institution: Social and Cultural Foundations 1823-1830

This study of the founding in 1823 of the London Mechanics’ Institution examines its constituency, catchment, and mandate to teach working men science and technology. To explain the Institution’s distinctive character, it is necessary to move beyond the flourishing patent/invention journalism, which provides one explanatory context, to the cheap literature disputes, debating society connotations, and Francis Place’s network. These radical associations show why George Birkbeck was quickly designated the ‘founder’, even though he was unknown to J. C. Robertson and Thomas Hodgskin when they proposed such an institute in the Mechanics’ Magazine. Birkbeck’s social standing would allay Establishment fears. An older historiography stressing middle-class social control is tested by analysing contemporary journals, newspapers and manuscripts. The first two volumes of manuscript Members’ Registers (1824-29), recording 8,343 names with occupations and addresses, have been transcribed and appended. These allow a comparison of members’ occupations with London trades generally and highlight diverse occupations within families. They also reveal family relationships between clerks and mechanics – important because clerks have been cited as a sign of middle-class invasion. Indeed the lack of any gross change in class composition suggests that there was no working-class exodus in these pre-Reform years. By statute two-thirds of the committee had to be working class. The encouragement of invention and student autonomy through mutual instruction classes, introduced by the Pestalozzian Charles Lane, points to a more humanitarian ethos, as do the lectures which (contra the learned societies) often presented science as negotiable rather than given. Iconic radical members are highlighted: Henry Hetherington (on the committee regularly from 1825-1830), William Lovett, James Watson, G. G. Ward, and P. O. Skene. Finally, the thesis analyses the committee’s relationships with controversial outsiders who rented the theatre, including Robert Owen, Eliza Macauley, William Cobbett, the Radical Reform Association, and the London Co-operative Society.
Operational characterization of quantum correlations

The proposed research aims at the operational characterization of features of correlations specific to quantum systems. This will lead to a deeper understanding of Quantum Mechanics (QM) and of the behaviour of correlated systems, and contribute to the development of revolutionary Quantum Information Processing (QIP) technologies. QIP applications include the efficient simulation of quantum systems, more precise sensors, secure communications, and, ultimately, incomparably faster computers. QIP was born from the recognition that information can be processed according to the laws of QM. At the core of the advantage of QIP over classical information processing lie quantum correlations, in which Dr Piani is an expert. Dr Piani will characterize several forms of quantum correlations in a systematic and unified way. The results will directly link to operational scenarios and applications, for example in metrology and communication. Where relevant, the characterization will take into account physical and practical constraints and limitations deriving from, e.g., the finite energy involved in physical processes and the necessarily incomplete information accessible to experimentalists. The host organization, the University of Strathclyde, will provide Dr Piani with the opportunity to establish a new research line in QIP at the Department of Physics, a stepping-stone towards a senior academic position. Thanks to his conceptual, mathematical and information-theoretic approach, Dr Piani will develop a research programme that will integrate and complement the research activities of the Computational Nonlinear and Quantum Optics (CNQO) group. As a member of the CNQO group, and especially through the collaboration with the supervisor Prof A. J. Daley, which is directed to the study and verification of quantum correlations in Atomic, Molecular, and Optical (AMO) physical systems, Dr Piani will develop and apply his expertise to AMO physics at the highest international level.
Structural Basis of HIV-1 Tethering to Membranes by the BST-2/Tetherin Ectodomain

The restriction factor BST-2/tetherin contains two membrane anchors employed to retain some enveloped viruses, including HIV-1 tethered to the plasma membrane in the absence of virus-encoded antagonists. The 2.77 A crystal structure of the BST-2/tetherin extracellular core presented here reveals a parallel 90 A long disulfide-linked coiled-coil domain, while the complete extracellular domain forms an extended 170 A long rod-like structure based on small-angle X-ray scattering data. Mutagenesis analyses indicate that both the coiled coil and the N-terminal region are required for retention of HIV-1, suggesting that the elongated structure can function as a molecular ruler to bridge long distances. The structure reveals substantial irregularities and instabilities throughout the coiled coil, which contribute to its low stability in the absence of disulfide bonds. We propose that the irregular coiled coil provides conformational flexibility, ensuring that BST-2/tetherin anchoring both in the plasma membrane and in the newly formed virus membrane is maintained during virus budding.
Analytical study of power generation efficiency of WtE systems operating in Tokyo special ward district

This paper attempts to present a fundamental system analysis for the performances of currently operating waste-to-energy incinerators in Tokyo special ward district. Firstly, it is stated that the gross thermal efficiency η
 G of any steam turbine generation system could be expressed as a product of four parameters: the boiler efficiency η
 b, turbine steam utilization fraction R
 t, heat cycle constant R
 h, and turbine generator chamber efficiency η
 tg. Secondly, reliable heat inputs to waste-to-energy systems were established by the ideal boiler efficiencies η
 b,ids which are based on the versatility of the standardized combustion gas properties, to avoid totally depending on the conventional low calorific value measurements of the fed-waste which occasionally include dubious results. Thirdly, the achievement of technological progress of power generation in waste-to-energy systems over the past 3 decades was reviewed. The advantage of 4 MPa class incinerators (installed after 2001) over 3 MPa class incinerators (installed before 1999) in η
 G by 33.1% on average was clarified. Fourthly, the difference in operational modes which affects the η
 G was studied to seek for the optimum operation in terms of energy recovery. In conclusion, this paper evaluated that the overall η
 G of the 20 incinerators in FY2015 proved to be 15.0%.
The impact of entrepreneurial capital and rapidly growing firms: the Canadian example

World-class competitiveness is no longer an option for firms seeking growth and survival in the increasingly competitive, dynamic and interconnected world. This paper expands on the concept of entrepreneurial capital (EC) and formalises it as a catalyst that augments other productive factors. It provides empirical evidence from small, young, high-growth enterprises that EC contributes significantly to their growth through such augmentation. As emerging industries and regions face similar challenges as those of high and rapidly-growing smaller enterprises in increasingly more hostile environments that also suffer from poor resources, this research offers significant lessons with implications for emerging firms, industries and associated regions that aspire to grow faster.
Why biodiversity declines as protected areas increase: the effect of the power of governance regimes on sustainable landscapes

Achieving sustainable landscapes that integrate food production with biodiversity conservation remains challenging, particularly in the tropics where most forest clearance results from conversion to industrial agriculture. Land-sparing (delineating protected areas and intensifying agricultural production from developed land) has often been identified as more effective than land-sharing (mixing protection and production in an agro-ecological matrix) for biodiversity in the tropics. Nevertheless, biodiversity decline continues despite protected area expansion meeting global targets under international conventions. We developed a low-order stock-and-flow model to consider this apparent paradox, and used it to structure deliberations on the impacts of the power of governance regimes. The model articulates our shared hypothesis about the basic dynamics of the social–ecological system. We present scenarios that depict plausible biodiversity change over time under three different governance regimes and land-use trajectories. The scenarios raise the possibility that, while land-sparing gives better short-term results for biodiversity, land-sharing may outperform it over time. Two key insights derive from our deliberations. First, the forces that drive forest clearance for development do not necessarily oppose those that drive forest protection; this decoupling helps explain why biodiversity loss continues as protected areas increase. Second, the power of the governance regimes that protect existing forest can be weakened by protected area expansion, through lowering public discourse about risks from biodiversity loss, while the power of governance regimes for development concurrently remain strong; this helps explains why some REDD+ schemes are associated with increasing deforestation. These insights suggest novel leverage points for sustainable tropical landscapes, such as prioritising protected area placement by proximity to active agricultural frontiers, rather than by representative biodiversity or cost-effectiveness; or using area-based conservation targets that include both the extent of protected areas and of other remaining forest habitat. We recommend further investigation of these ideas, and of collaborative conceptual modelling approaches, to explore solutions for sustainable tropical landscapes.
Japanese familial case of myoclonus-dystonia syndrome with a splicing mutation inSGCE

Myoclonus-dystonia syndrome (MDS) is a rare autosomal-dominant movement disorder characterized by brief, frequently alcohol-responsive myoclonic jerks that begin in childhood or early adolescence, caused by mutations in the ε-sarcoglycan gene (SGCE). The patient was a 6-year-old boy. At 2 years 8 months, he had abnormal movement when he ran due to dystonia of his left leg. At 3 years 5 months, he exhibited dystonia and myoclonic movement of his arms when eating. Myoclonus was likely to develop when he felt anxiety or exhaustion. Genomic DNA showed a heterozygous mutation in SGCE (c.109 + 1 G > T). His father and uncle with the same mutation also experienced milder dystonia or myoclonic movements. SGCE mutation can cause a broad range of clinical symptoms between and within families. We should consider MDS as a differential diagnosis for patients with paroxysmal walking abnormalities and/or myoclonic movements.
Load Measurement Method of the MW Class Wind Turbine

In recent years, wind turbine tower buckling and blade broken often happened. Large wind turbine load and insufficient fatigue strength should be the main reasons. To prevent this case, load measurement of the wind turbine is necessary. The wind turbine load measurement is one of the type tests of wind turbine. The load of the wind turbine structure components will strongly affect the safety and life span of the wind turbine. The wind turbine load measurement can help the wind turbine manufacturer and wind farm operator to know the structural response of the wind turbine components with different load cases. According to the IEC 61400-13 standard, a method of the wind turbine load measurement is introduced in this article. Meanwhile, the measurement results are given in this article. The results indicate that the accuracy of this measurement method can fulfill the requirements of the related standards.
Turismo de bicicleta na planície Pannonian

A operação tem por objeto o cofinanciamento dos custos elegíveis para a execução da operação de ciclismo de turismo na planície panónica.
Nervous system reprogramming by flexible neuropeptidergic networks

Animal brains are wired according to a series of remarkable genetic programs that have evolved over millions of years. Much of our behavior, however, is the product of experiences that happen to us on much shorter time scales. The ability of the nervous system to properly respond to aversive stimuli is crucial for animal well-being and survival. In many vertebrate sensory systems, persistent stimuli are coded by tonically active neural circuits. As opposed to phasic sensors that adapt rapidly, tonic neurons reliably convey stimulus intensity over long time periods and are essential for cues that need to hold attention, e.g. harmful stimuli. How persistent aversive stimuli are molecularly encoded and reprogram behavior remains elusive. Our working hypothesis is that aversive challenge recruits a network of neuropeptide signaling pathways that is sculpted by experience and mediates diverse acute and long-lasting behavioral responses. 

We will test this hypothesis on the small and well-described oxygen-sensing circuit of C. elegans. Because neuropeptidergic networks are notoriously complex, such a highly controlled context for pioneering research on their involvement in tonic aversive signaling is preferable. First, my team will develop tools for the in vivo reporting of neuropeptide GPCR activation, establishing SPARK in a living animal, which will allow conceptual advancements with unprecedented detail. Pertinent questions we will then address include: ‘How do cellular networks respond to changes in neuropeptidergic network activities in an aversive signaling context?’; ‘What are behavioral implications of neuropeptidergic network activity upon aversive challenge?'; and ‘Do neuropeptidergic networks contribute to cross-modality?'

We expect that on the long term, this project will impact our understanding of how tonic peptidergic circuits influence and organize habituation, learning, forgetting and modus operandi of nervous systems in general.