SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Lung cancer fusion genes: a new diagnostic device

The main scope of LEONID project is the development and validation of the clinical performance of a new diagnostic Nanostring-based device against existing standards (FISH and IHC) for the detection of in vitro biomarkers with predictive power of response to tyrosin kinase inhibitors used for lung cancer treatment. 
The device will be the first CE-IVD kit that detects all ALK, ROS1 and RET rearrangements with known and unknown partners in one multiplex assay and that, at the same time, identify the main variants of EML4-ALK.
The clinical validation will be extended to the associated software for secondary analysis of data that will guarantee the results standardization, avoiding any personal interpretation. The new diagnostic device-software combination, that passed the technical feasibility analysis and is ready for experimental verification, will be the easiest, cheapest, fastest and standardized solution for ALK, ROS1 and RET fusions detection without losing sensitivity, specificity, robustness and reproducibility.
The end users will be all molecular pathology laboratories supporting hospitals where lung cancer patients are treated, that (are going to) perform the analysis of fusion genes and want to reduce hands-on-time, error rate, and costs, saving specialized technical expertise and increasing the throughput of biomarkers and samples. At least 85 European medium-high throughput labs running 450 lung samples per year can be considered as potential customers.
For Diatech Pharmacogenetics, the new device will be complementary to the existing products for pharmacogenetics analysis in oncology and will boost the company’s approach of potential European distributors. GeneticLab can offer the test to low throughput labs and can speed up the entrance into the oncology business. BiMind can extend the panel of features of its proprietary oncology EHR dedicated to the analysis of laboratory tests’ results and can provide its new software through Diatech PGx or directly.
Innovation, Culture and Creativity for a new Economy

Regional development can successfully integrate cultural and creative industries (CCI) in many areas of economy. To fully exploit their economic potential, the CCI need to increase their capacity to experiment and innovate. In this framework, the project objectives are:
• Identifying main cultural events and heritage assets at regional level to be considered the engine for the development and promotion of creative industries, for the attraction of the audience and the tourists.
• Strengthening the cultural assets and the creative industries, functional improvement of the different activities and structures, involvement of the cultural and creative enterprises with innovative ideas for processes and products of the cultural assets.
• Reinforcing the capacity of CCI to be active in supporting the development of the cultural events and heritage assets and creation of a professional network.
• Developing the capacity of both cultural assets and creative industries to be part of an advanced and smart economic system
• Improving competitiveness, making the culture an actual engine of local development and finding new sustainable ways for economic growth by merging private and public potential.
Future optical networks for innovation, research and experimentation

Future (5G) services will impose stringent requirements in the design and operation of transport networks: increased capacity, low latency, high availability and dynamicity, reduced service provisioning with lower OpEx, while considering end-to-end service objectives (QoS and QoT). 
To cope with traffic growth in a cost-effective way, an appealing strategy focuses on deploying elastic and programmable commodity optical hardware via disaggregation (white boxes) combined with transmission technologies. 
To address both end-to-end service objectives and traffic dynamicity, an interesting approach leverages the benefits provided by SDN/NFV control and the automated decisions and re-configuration opportunities enabled by cognitive algorithms. For this, SDN/NFV provides unified control on top of systems’/devices’ programmability, regardless of the data infrastructure (packet, optical, IT), while exploiting the large real-time monitored information dynamically to adopt actions leading to attain service end-to-end objectives and more optimal network operation and resource utilization.
Those hardware and software solutions constitute ONFIRE R&D goals which basically target the design, deployment and experimental evaluation of disaggregated optical transport hardware automatically articulated by novel cognitive algorithms supported by a SDN/NFV architecture. To do so, ONFIRE proposes a three-year research programme centred on two European industrial PhDs. PhD candidates will benefit from an intensive training process combining the strengths of both: i) CTTC as research institution to acquire research tools and methodology, with UPC as associated partner offering its PhD programme; ii) ALUD as a vendor delivering a highly valuable view of research activities and its impact on industrial ecosystem. Targeted PhD training programme is devised to maximize the synergy between the collaborators and promote career opportunities of ONFIRE researchers in the European ICT Research Area.
CONTROL ASSEMBLY FOR HEAT OR COLD INPUT IN A MIXED APPARATUS COMBINING A HEAT PUMP WITH A WOOD FIREPLACE

The invention relates to an assembly for controlling and adjusting the air outlet temperature T of a mixed apparatus including a closed-hearth fireplace and a heat pump PAC in which one of the batteries is located at the air outlet duct (7) of the mixed apparatus, characterised in that a control circuit is mounted on the operation main control of the heat pump PAC, for adjusting the RPM speed of the fan or turbine (10) of the battery placed in the air outlet duct (7), based on the air outlet temperature T measured by a thermal probe (11) located in the air outlet duct (7) downstream from the hot air outlet of the fireplace, in order to obtain an adjusted air temperature at the outlet. The invention is particularly intended for closed-hearth fireplace manufacturers.
Ai for new devices and technologies at the edge

The fundamental goal of the ANDANTE project is to leverage innovative hardware platforms to build strong hardware / software platforms for artificial neural networks (ANN) and spiking neural networks (SNN) as a basis for future products in the Edge IoT domain, combining extreme power efficiency with robust neuromorphic computing capabilities and demonstrate them in key application areas. 
The main objective of ANDANTE is to build and expand the European eco-system around the definition, development, production and application of neuromorphic hardware through an efficient cross-fertilization between major European foundries, chip design, system houses, application companies and research partners, as presented by the European Leader Group (ELG).
The project brings together world class expertise to bring the world class expertise and infrastructures of Imec, CEA and FhG together with semiconductor companies, fabless, system houses, SMEs and application experts to explore and demonstrate the capabilities provided by the developed technologies. In the project, several applications will be assessed in key domains where Europe is strong (automotive, digital farming, digital industry, mobility and digital life). The aim is to reinforce and maintain strong leadership in these areas by bringing industry in contact with future memory technologies at a low TRL level (MRAM, OXRAM, FeFET). These cross-disciplinary efforts will lead to development of innovative hardware / software deep learning solutions, based on high TRL level RRAM/PCM and FeFET, to enable future products which combine extreme power efficiency with robust cognitive computing capabilities. This new kind of computing technology, combining ANN and SNN capabilities, will open new perspectives, for instance, environmental monitoring, and wearable electronics.
Low cost robotic platform based on Player/Stage architecture and La Fonera hardware

This paper presents a low-cost proposal for the development of a remote laboratory, offering the possibility of providing learning in the field of robotics for users with no need to be physically in the laboratory, or simply not having to take the robotic platform to reprogram it, also giving the option of working with the same platform to a group of users to test their algorithms by turns. The system is based on a Wi-Fi router updated with a Linux firmware, connected to a control board that manages the hardware of a mobile robot. The microprocessor has been also loaded with the Player Server environment, widely used in commercial robotic platforms for research.
MILLING TOOL

The invention relates to a milling tool having a rotation axis D, consisting of a tool shank -1- and a cutting region -2-. The cutting region -2- has at least one wiper cutting edge -3- which runs approximately perpendicularly to the rotation axis D and which merges at the circumference into a main cutting edge -4- and at the centre into a secondary cutting edge -5-. The secondary cutting edge -5- is offset rearwards from the wiper cutting edge -3- in the direction of the rotation axis D. According to the invention, a notch -6- designed as a cutting edge section is formed in the transition zone between wiper cutting edge -3- and secondary cutting edge -5-. The point -7- of this notch -6-, said point -7- being the rearmost point as seen in front view in the direction of the rotation axis D, lies behind the foremost point -8- of the secondary cutting edge -5-, wherein the angle a between the wiper cutting edge -3- and the adjoining section of the notch -6- is within the range of 90° to 175° and the angle ß between the wiper cutting edge -3- and that section of the notch -6- which adjoins the secondary cutting edge -5- is within the range of 3° to 90°. The angle Y between that section of the notch -6- which adjoins the secondary cutting edge -5- and the secondary cutting edge -5- is within the range of 90° - 177°.
Platform for 3d planning of future energy and linear network connected with augmeted reality for improved public participation

Interactive collaborative 3D cloud-based platform using a large database of digital maps and satellite images supporting
power grid operators in planning the future energy infrastructures faster, cheaper, more visual, more interactive and more
socially accepted by improving the communication and social acceptance with public authorities and local communities in the
permitting process. Instead of using current manual and paper-based methods, experts and planners at power grid operators
will be able to map and visualize in 2D - 3D technical, environmental, regulatory, economic and social factors determining
the map of suitability to the construction of new power lines and to interactively calculate in few minutes multiple solutions
and their corresponding technical and economic parameters. Instead of using steady images on posters when presenting a
project, the usage of virtual and augmented reality (VR/AR) on mobile devices will improve the communication between
power grid operators and local communities and administrations in order to increase the chances to find a common
agreement. This will reduce the local opposition usually leading to a delay or to the death of projects. The collection of
feedback from different locations in the landscape by using AR/VR allows to generate the map of the social acceptance of
new power lines and to identify critical regions which need alternative solutions such as underground cables. The map of
social acceptance is a novelty that could be applied to plan infrastructures such as wind farms, roads and future
transportation systems. The software has been created, tested and validated in collaboration with power grid operators
which provided also case studies. Our solution has been awarded with the 1st prize of the Innovation Challenge promoted by
Elia Grid in 2017. Two power grid operators are currently paying for our solution.
Nutrients in anoxic oceans – trace metals in modern and ancient environments

The global oceanic oxygen content has decreased by more than 2% since 1960 and is projected to drop further in the near future. This decline could drastically impact ocean nutrient cycles and marine life, but the exact progression of ocean anoxia and its impacts are hard to predict. Earth's history is punctuated by intervals of widespread ocean anoxia that manifest themselves in the sedimentary record as specific intervals of enhanced organic-carbon burial. These intervals last for 10,000-100,000s years, are marked by perturbations to global climate and biogeochemical cycles, represent major environmental disturbances, and are often associated with mass extinctions. The study of such past climate disturbances can improve projections of future ocean anoxia and environmental change by providing better constraints on the model boundary conditions. However, this requires the detailed reconstruction of past environmental parameters based on the sedimentary record. This project aims to develop and apply new ways of using geochemical tracers for past ocean environments. The focus is on the role of trace metals in anoxic waters and their impact on marine life and biogeochemical cycles.
Trace metals are essential to life and are taken up in phytoplankton cells but are also reactive towards dissolved sulphide. Though such processes leave diagnostic geochemical imprints on the isotope composition of the marine sedimentary record, their interpretation is often complicated as a result of this dual sensitivity. This research project will establish new methods to distinguish between these two controls. These methods will then be applied to samples from a variety of modern environments to establish a thorough understanding of trace metal cycling in anoxic waters. Combined with biogeochemical modelling, these new methods will then be used to reconstruct the interplay between global warming and biogeochemical cycles during an interval of widespread anoxia in the Cretaceous.
Artificial-Intelligence driven discovery and synthesis of polyoxometalate clusters

We outline a 5 year programme that introduces a new platform for the preparation, understanding, and exploitation of precisely defined nano-molecules / materials based upon the assembly of molecular metal oxide precursors (polyoxometalates) under non-equilibrium conditions with well-defined physical properties using automated intelligent feedback. We will elucidate the mechanism of assembly of these gigantic molecules and  devise a set of rules similar to the magic numbers found in gold nanoclusters, using these to break the 10 nm size barrier for a single molecule. Targeted properties include photochemical and electrochemical sensors, bistable molecules, doped traditional oxides with polyoxometalates, and new catalysts including water oxidation via a Universal Building Block (UBB) approach that links properties of the building blocks with emergent properties of the resulting clusters and materials for the first time. The new approach includes the conversion of batch to flow synthesis not only for automation, but to understand fundamental mechanistic aspects, and to use artificial intelligence algorithms to help move through the myriad of possible combinations (without needing to synthesise every possible molecule).  The SMART-POM approach is therefore not merely automation of one-pot chemistry, but an entirely new paradigm building on our recent developments and will allow us to move through a vast combinatorial space effectively only locating areas of novelty via feedback control. This feedback will be used to discover, design, and develop complex, adaptive and functional metal oxide-based materials based upon sensory feedback from the physical properties measurements. Thus SMART-POM will open up a whole new synthetic space, give mechanistic understanding, and allow the discovery of molecules with potential real-world applications. Finally, we will aim to extend the SMART-POM paradigm to other areas of chemistry which will benefit from the search for novelty.
Cultural theory as Mood Work

In staging an encounter between Sedgwick’s discussion of reparation, Spivak’s analysis of translation, and critical scholarship on mood, this essay considers how we might understand contemporary cultural theory as a form of ‘mood work’ that is at once discursive and material, textual and affective, political and aesthetic. In particular, I am interested in how thinking reparation, translation and mood together might open up different ways of conceptualising and negotiating the affective ‘double binds’ central to both critical thought and socio-political relations at the current conjuncture. As Sedgwick and Spivak each show us, I will argue, tarrying with contradiction and ambivalence is the mood work that cultural theory must continue to pursue, both in order to understand the material implications of our own emotional investments in intellectual production and to appreciate the complex ways in which power operates within the structures of feeling of late liberalism.
Method and apparatus for the recovery of hydrocarbons

A steam generator for burning a normally-solid fuel which produces non-combustible solid residues, including, an elongated combustion chamber, a fuel introduction means to introduce fuel adjacent the axis of the combustion chamber as a centrally-disposed stream moving in a downstream direction, a combustion-supporting gas introduction means for introducing the gas as an annular, rotating stream about the fuel stream and which, together with the fuel introduction means forms a rotating, toroidal vortex of the fuel and the combustion-supporting gas moving in a downstream direction. The combustion chamber has a volume sufficient to burn all of the fuel and, together with the fuel introduction means and the combustion-supporting gas introduction means, cause the vortex to collapse and form plug flow thereafter. Water introduction means introduces water into the flue gas at the downstream end of the combustion chamber as a plurality of peripherally-arranged jets. Preferably the water is introduced from the vena contracta of a nozzle-type orifice. A vaporization chamber, coupled to the combustion chamber, has a volume sufficient to vaporize a major portion of the water to steam and a separator separates solid residues from the flue gas-steam mixture.
Improving the Held and Karp Approach with Constraint Programming

AbstractHeld and Karp have proposed, in the early 1970s, a relaxation for the Traveling Salesman Problem (TSP) as well as a branch-and-bound procedure that can solve small to modest-size instances to optimality [4, 5]. It has been shown that the Held-Karp relaxation produces very tight bounds in practice, and this relaxation is therefore applied in TSP solvers such as Concorde [1]. In this short paper we show that the Held-Karp approach can benefit from well-known techniques in Constraint Programming (CP) such as domain filtering and constraint propagation. Namely, we show that filtering algorithms developed for the weighted spanning tree constraint [3, 8] can be adapted to the context of the Held and Karp procedure. In addition to the adaptation of existing algorithms, we introduce a special-purpose filtering algorithm based on the underlying mechanisms used in Prim’s algorithm [7]. Finally, we explored two different branching schemes to close the integrality gap. Our initial experimental results indicate that the addition of the CP techniques to the Held-Karp method can be very effective.The paper is organized as follows: section 2 describes the Held-Karp approach while section 3 gives some insights on the Constraint Programming techniques and branching scheme used. In section 4 we demonstrate, through preliminary experiments, the impact of using CP in combination with Held and Karp based branch-and-bound on small to modest-size instances from the TSPlib.KeywordsSpan TreeMinimum Span TreeTravel Salesman ProblemTravel Salesman ProblemConstraint ProgrammingThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
ANTRAG AUF ERLEICHTERUNG ZUR UNTERSTÜTZUNG DER FIRMA GARTENSTRUKTUREN HOLZ SRL

ANTRAG AUF ERLEICHTERUNG ZUR UNTERSTÜTZUNG DES UNTERNEHMENS IM ZUSAMMENHANG MIT DER DURCH DIE COVID-19-PANDEMIE VERURSACHTEN NOTLAGE UND IN BEZUG AUF DIE WIRTSCHAFTS- UND SOZIALKRISE IM HINBLICK AUF DIE PRODUKTIVE ERHOLUNG
New, advanced and value-added innovative ships

To maintain world leadership in complex, value-added and highly specialised vessels European shipbuilders must develop tailor-made innovative concepts that are efficient to design and build. Project NAVAIS proposed solution is a platform-based modular product family approach supported by the 3DEXPERIENCE integrated business platform. By sharing components and production across a platform of vessels, higher efficiency in vessel design and  flexibility in production networks is achieved. NAVAIS uses system engineering approaches to develop the principles, procedures and a re-use component library for modular design and production and will apply these to develop two platform-based product families: passenger/road ferries and multi-use workboats. For each product family a demonstrator will be developed to TRL9 “digital twin”-level, validated and assessed on low impact environmental performance e.g. discharges to air and water, underwater radiated noise and cost-benefit aspects. The demonstrators are a 400 passengers/120 cars E-ferry and a multi-use workboat equipped for aquaculture activities. A major aspect of the platform-based modular approach is the change in value chain management. The current class approval procedure of engineered-to-order designs will be replaced by a procedure where pre-engineered product modules are approved by class, stored in a re-use library and applied in new vessel modular designs. This transfer from an engineered-to-order business model to an assemble-to-order business model will allow shorter process lead-times, constant quality, reduced design and production costs and better integration of the SME supply chain. Exploitation of results is expected at the end of the project duration. NAVAIS partnership contains 16 partners from 5 EU and 1 associated countries and includes technology providers, technology integrators and technology users. The project duration is 4 years and the required funding is € 6,6 MIO.
Analysis of horizontal flows in the solar granulation

Solar limb observations sometimes reveal the presence of a satellite lobe in the blue wing of the Stokes I profile from pixels belonging to granules. The presence of this satellite lobe has been associated in the past to strong line of sight gradients and, as the line of sight component is almost parallel to the solar surface, to horizontal granular flows. We aim to increase the knowledge about these horizontal flows studying a spectropolarimetric observation of the north solar pole. We will make use of two state of the art techniques, the spatial deconvolution procedure that increases the quality of the data removing the stray light contamination, and spectropolarimetric inversions that will provide the vertical stratification of the atmospheric physical parameters where the observed spectral lines form. We inverted the Stokes profiles using a two component configuration, obtaining that one component is strongly blueshifted and displays a temperature enhancement at upper photospheric layers while the second component has low redshifted velocities and it is cool at upper layers. In addition, we examined a large number of cases located at different heliocentric angles, finding smaller velocities as we move from the centre to the edge of the granule. Moreover, the height location of the enhancement on the temperature stratification of the blueshifted component also evolves with the spatial location on the granule being positioned on lower heights as we move to the periphery of the granular structure.