SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Combined usage of testosterone and nandrolone may cause heart damag

The aim of this study is to determine the effects of combined application of testosterone and nandrolone on male rabbits during adolescence period for biochemical values which are indicators of damage to heart, liver and kidney. Seven male New Zealand white rabbits, 60-days old, were used in this study. Testosterone (10 mg/kg) + nandrolone deconoate (10 mg/kg) were injected simultaneously to the rabbits in an intramuscular manner once in 1 week for a period of 12 weeks. Blood samples were taken in 0, 4, 8 and 12 weeks. Serum creatine kinase-MB, lactate dehydrogenase, alkaline phosphatase, alanine aminotransferase, aspartate aminotransferase, gamma-glutamyl-transferase, creatinine and blood urea nitrogen were measured with an auto-analyzer. Combined use of testosterone and nandrolone caused (p 0.05) were determined in other parameters. As a result, it can be concluded that the use of testosterone plus nandrolone simultaneously during early ages may cause heart damage. Key words: Testosterone, nandrolone, creatine kinase-MB.
Human genetic basis of severe staphylococcal infections in childhood

Staphylococcus aureus is one of the most important bacterial pathogens impacting human health. Beta-barrel pore-forming toxins (BB-PFTs) are major virulence factors of S. aureus that destroy phagocytes, key effectors of immunity during staphylococcal infection, in a receptor-specific manner. Acquired immunity to a specific compound of S. aureus, LTA, can rescue an inborn error of the TLR2 pathway (TIRAP deficiency). I hypothesize that severe staphylococcal infections during childhood, at least in some patients, can result from single gene inborn errors of immunity. Some of these disorders may affect immunity to BB-PFTs and the TLR2 pathway. In this project, a cohort of ±70 patients with severe S. aureus infections during childhood will be investigated for mutations responsible for a poor outcome of infection. I will perform whole exome sequencing in these patients and their parents. I will search for mutations in genes encoding BB-PFT-receptors and the TLR2 pathway. I will also search for mutations in a genome-wide approach, testing various genetic models and taking advantage, when appropriate, of genome-wide linkage. I will then functionally characterize the candidate mutations. Depending on the gene identified, a set of experiments will be performed to investigate the functional consequences of the morbid gene on immunity against S. aureus, and I will further characterize the specific host-pathogen interaction. This project will not only shed light on the pathogenesis of S. aureus, but will also provide the basis for new avenues of vaccine and treatment strategies. By investigating human host counterparts in a genome-wide setting, this study is the first unbiased and systematic assessment linking S. aureus virulence factors with host genetic predisposition.
INSULATION MATERIAL AND METHODS OF PREPARING AND INSTALLING SAME

The present invention relates to insulation material and methods for preparing and installing same. In preferred embodiments of the present invention, the insulation material contains a combination of wool, a structural fibre, a bonding agent and a packing fibre. The structural fibre provides a network having interstices in which the wool and packing fibres are situated. The bonding agent bonds the structure together. This combination provides good insulation qualities and a stable structure.
Some modal aspects of XPath

This paper provides several examples of how known results in modal logic can be applied to the XML document navigation language XPath. The applications concern complete axiomatizations and expressive power. XML is a standard for storage and exchange of data on the Internet. It is tailored towards hierarchically structured data, and its basic data structure is that of a (finite) sibling-ordered tree: a tree in which the children of each node are linearly ordered. XPath is a language used for retrieving elements from XML documents. As has been observed by several people, XPath is closely related to modal logic. In this paper, we illustrate the connection by showing how a number of (old and new) results on XPath fragments can be derived from known results in modal logic. These results concern axiomatizations and expressivity of XPath fragments, both of which are important topics in database theory. For instance, complete axiomatizations for XPath fragments can be understood as complete sets of rewrite rules. Identifying e! ective rules for rewriting expressions to simpler but equivalent ones is important for query optimization.
Structural role of protein splicing factors in promoting an active configuration of the spliceosome's rna catalytic core

The spliceosome is a ribonucleoprotein machine that excises introns from pre-messenger RNAs. During my phD, I identified RNA ligands for the magnesium ions that catalyze these splicing reactions and showed that the spliceosomal U6 and U2 small nuclear RNAs form a structure resembling group II self-splicing intron RNAs. Although the spliceosome's catalytic core is RNA-based, numerous spliceosomal proteins promote the proper catalytic fold of this RNA core, juxtapose the reactive pre-mRNA elements with the U6 metal sites, and regulate spliceosome dynamics during the splicing cycle. Indeed, the Prp8 protein cross-links with the critical nucleotides of the catalytic RNA core and its crystal structure, reported recently by the host laboratory, revealed a cavity that accommodates the catalytic RNA core. Moreover, several helicases, such as Brr2 and Prp16, promote an active configuration of the U2/U6 RNA core and associated proteins and regulate their dynamics. The arrangement of such proteins in the assembled spliceosome and their interactions with the RNA core is presently unknown due to the lack of high-resolution structures of any spliceosomal complexes. I will study biochemically in vitro the interactions between the U2/U6 core and key proteins necessary for an active fold of the RNA core, with the goal of reconstituting and solving the high-resolution structure of a minimal active U2/U6 RNA core in complex with the reactive pre-mRNA sites and surrounding proteins including Prp8. In parallel, I will employ recent advances in cryo-electron microscopy sample preparation, imaging, and data processing, which were pioneered at the host institute, to obtain high-resolution (at least 7 Angstroms) three-dimensional reconstructions of endogenous fully assembled spliceosomes stalled at specific splicing stages. These studies promise to provide unprecedented structural insihgt into the configuration and dynamics of key RNA and protein elements of the spliceosome.
A shrink fit chuck means for holding a drill bit

A unitary drill bit using components comprising a drill bit 46, and a chuck 30, such that the chuck 30 is heat shrunk onto the drill bit 46, the chuck 30 also includes a threaded portion 38 for attachment to a drilling device 54. Other embodiments include where said drilling device is a hand drill driven by an air motor.
Cool ways of using low grade heat sources from cooling and surplus heat for heating of energy efficient buildings with new low temperature district heating (ltdh) solutions.

The COOL DH project will innovate, demonstrate, evaluate and disseminate technological solutions needed to exploit and utilise sources of very low-grade ""waste"" heat for heating of energy efficient buildings via Low Temperature District Heating (LTDH) and show how the District Heating (DH) systems can be more resource efficient and
more energy efficient. The demonstration covers both new developments and stepwise transition of existing areas with district heating and energy retrofitting of buildings. The COOL DH consortium consists of the utilities and municipalities of the two cities Lund (SE) and Høje-Taastrup (DK) and leading DH energy specialists as well as leading industrial manufacturers.
COOL DH will:
- Innovate, design and build cooling and heat recovery process systems, enabling heat recovery to a local low- temperature district heating grid. They will mainly be driven by renewables. Design work will start in 2017 and heat recovery will start in 2019.
- Design and build a low-temperature district heating grid with non-conventional pipe materials and testing of new innovative pipe components that will become new products introduced as a result of COOL DH.
- Innovate and design suitable innovative heating systems and controls inside buildings that combine LTDH with distributed integration of local produced renewable energy on the buildings. Erection of new buildings in Lund will start in 2018 and will continue throughout the time of this project, while LTDH in Høje-Taastrup mainly will be for existing buildings being refurbished including modification of the heating system.
- Develop viable business models and new pricing systems, that ensures a good (low) return temperature and provide the building companies with maximum flexibility regarding the choice of heating systems.
- Demonstrate a full system with all needed components suitable for ultra-low DH temperatures (40 oC) incl. demonstration of systems for heating of DHW without risk of legionella.
ENHANCEMENT OF CULTURAL HERITAGE THROUGH ENVIRONMENTAL PLANNING AND MANAGEMENT

Cultural Heritage sites located in both rural and urban areas are often facing the dilemma between loss of cultural values and hence loss of identity, due to non-sustainable growth, and economic decline and emigration, due to inappropriate infrastructure and high cost of living (especially, buildings maintenance). CHERPLAN aims to provide a strong basis for ensuring compatibility and synergy between Cultural Heritage conservation and socio-economic growth by fostering the adoption of a modern Environmental Planning approach throughout SEE. The aim of EP is to integrate traditional urban/spatial planning with the concerns of environmentalism to ensure sustainable development; when innovatively applied to CH sites, EP's comprehensive perspective can be regarded as composed of three spheres: the built and historical environment, the socioeconomic and cultural environment, and the biophysical environment. "Natural" (often human-induced) disasters are one of the factors to consider: CH sites are particularly vulnerable to such events, as they are scarce, valuable and non-renewable. A multilevel and multi-sectoral Partnership will ensure effective achievement of these goals. To promote efficient participatory management of CH sites, Cultural Site Management Partnerships will be established in the framework of Pilot Projects concerning 7 selected CH sites in the involved countries: subsequent to organization of workshops and training, Action, Business, and Environmental Management Plans will be prepared. The process is expected to lead to conflict reduction (CH is often perceived as a hindrance to development), durable jobs creation (to be linked to durable assets such as CH sites) and integration of minorities and their cultural backgrounds into the participatory scheme. Finally, an EP Model will be developed as a strategic tool for lasting transferability of project results, supported by a Memorandum of Understanding to be signed by the 4 involved Ministries of Culture.
Uncertainty analysis for extreme flood events in a semi-arid region

Extreme flood events are complex and inherently uncertain phenomenons. Consequently forecasts of floods are inherently uncertain in nature due to various sources of uncertainty including model uncertainty, input uncertainty, and parameter uncertainty. This paper investigates two types of natural and model uncertainties in extreme rainfall–runoff events in a semi-arid region. Natural uncertainty is incorporated in the distribution function of the series of annual maximum daily rainfall, and model uncertainty is an epistemic uncertainty source. The kinematic runoff and erosion model was used for rainfall–runoff simulation. The model calibration scheme is carried out under the generalized likelihood uncertainty estimation framework to quantify uncertainty in the rainfall–runoff modeling process. Uncertainties of the rainfall depths—associated with depth duration frequency curves—were estimated with the bootstrap sampling method and described by a normal probability density function. These uncertainties are presented in the rainfall–runoff modeling for investigation of uncertainty effects on extreme hydrological events discharge and can be embedded into guidelines for risk-based design and management of urban water infrastructure.
Carga e Descarga no Setor de Mercadinho no Município de Imperatriz-MA: Uma Análise da Problemática Logística / Loading and Unloading in the Mercadinho Sector in the Municipality de Imperatriz-MA: An Analysis of the Logistics Problem

Resumo: A carga e descarga em grandes centros é complexo, contraproducente e impróprio devido ao atraso logístico gerado com o trânsito para que, por sua vez, amplie a superlotação em outras vias. O município de Imperatriz-MA possui grandes feiras abertas, mas o Mercadinho se destaca pelo seu porte, diversidade de produtos e problemáticas, como o caso de carga e descarga que atrapalham o trânsito. Deste modo, o presente estudo tem como objetivo analisar a problemática da carga e descarga no perímetro do Mercadinho no município de Imperatriz-MA. A metodologia do artigo é um estudo de caso de ordem qualitativa de cunho exploratório com suporte em artigos, teses e dissertações para fundamentar o referencial teórico em conjunto com a observação da amostra de estudo. Os resultados obtidos apontam que não existe nenhuma política pública para delimitar ou regular a carga e descarga no setor que, por sua vez, gera um gargalo logístico e de trânsito. Em alguns locais no Brasil, existem locais direcionados às feiras e normativas que determinam um período para carga e descarga. Portanto, conclui-se que, o problema no setor do Mercadinho é de ordem pública, pois não há iniciativas ou planejamento para regular essas questões de trânsito.Palavras-chave: Carga. Descarga. Feira. Engenharia de trânsito. Abstract: Loading and unloading in large centers is complex, counterproductive and inappropriate due to the logistical delay generated by traffic, which, in turn, increases overcrowding on other roads. The city of Imperatriz-MA has large open fairs, but grocery store stands out for its size, diversity of products and problems, such as loading and unloading that hinder traffic. Thus, the present study aims to analyze the problem of loading and unloading in the perimeter of grocery store in the municipality of Imperatriz-MA. The methodology of the article is a qualitative case study of an exploratory nature supported by articles, theses and dissertations to support the theoretical framework together with the observation of the study sample. The results obtained indicate that there is no public policy to delimit or regulate loading and unloading in the sector, which, in turn, generates a logistical and transit bottleneck. In some places in Brazil, there are places dedicated to fairs and regulations that determine a period for loading and unloading. Therefore, it is concluded that the problem in the grocery store sector is of public order, as there are no initiatives or planning to regulate these traffic issues.Keywords: Load. discharge. Market. traffic engineering
METHODS AND KITS FOR DETECTING FUNGAL INFECTION

Methods and kits which utilize a conjugate, preferably an adduct, of ergosterol for determining the presence or level of a broad spectrum of ergosterol-containing organisms (e.g., fungi) in various substrates are disclosed. These methods and kits can be used to accurately and efficiently diagnose a subject having a fungal infection, particularly invasive fungal infection, and to accurately and efficiently detect the presence of fungi and other ergosterol-containing organisms in other substrates. Antibodies and other compounds (e.g., molecularly imprinted polymers) that are capable of selectively binding to ergosterol or to an ergosterol-containing conjugate and methods of producing same are also disclosed.
FORMULATIONS HAVING BENZOATE DYE CARRIERS FOR META-ARAMID ARTICLES

Glycol ether benzoates, glycol benzoates and methyl benzoate facilitate the dyeing of the meta-aramid article, e.g., fibers, at or near neutral pH. The addition of an anionic surfactant, such as sodium lauryl sulfate, enhances the performance of the benzoates.
Politicians’ traits and public policies: learning how personal features influence fiscal outcomes

Nowadays there is little doubt that maximizing social welfare is not the sole goal of policymakers. Policy choices such as the level of taxation and spending are at the core of public economics. A positive approach to this field takes into account the fact that budgets and policies are set by political agents who are office-seekers. Early studies on political economy have focused on institutional factors, voters’ preferences, interests groups, and party ideology as major drivers of public policies. But a growing number of theoretical and empirical studies have started to examine the particular features of political leaders (e.g. gender or ethnicity) as relevant determinants of economic outcomes and policies.

This project seeks to contribute to the understanding of how the individual traits of politicians affect public policies. This approach shifts the focus of attention from political parties to individual legislators. In examining the impact of parties on policies, studies often treat parties as homogeneous units. In contrast, this project takes into consideration the heterogeneity of its members in several dimensions. 

In particular, this project revolves around two topics. First, the politician‘s loyalty to her political party and its impact on public spending. A legislator may be reluctant to follow the party line if this generates a conflict with her constituents’ interests. To foster loyalty, parties may use discretionary spending targeted at specific districts. The second topic is the level of education of politicians. This project examines the possibility that education is not only a reflection of the level of skills but it acts as a dimension of political representation.
The horizontal positioning and interference analysis of submarine buried cable

Submarine cables are routed on the seabed, electricity and data are transmitted through long distance communication undersea submarine cable. In the process of the power and data transmission on the submarine cables, the current generates magnetic field and electric field, so it presents a certain electromagnetic in the seawater. By detecting submarine cables, the electromagnetic characteristics of the submarine cables can be extracted the from the marine environment, the location of the submarine cables can be infered. This paper carry out the research on electromagnetic positioning method and position interference, the location and the disruption of the submarine cable were simulated by numerical method, the specific conclusions are given.
Model-based diagnosis of spreadsheet programs: a constraint-based debugging approach

Spreadsheet programs are probably the most successful example of end-user software development tools and are used for a variety of purposes. Like any type of software, they are prone to error, in particular as they are usually developed by non-programmers. While various techniques exist to support the developer in finding errors in procedural programs, the tool support for spreadsheet debugging is still limited. In this paper, we show how techniques from model-based diagnosis can be applied and extended for spreadsheet debugging by translating the relevant parts of a spreadsheet to a constraint satisfaction problem. We additionally propose both problem-specific and generalizable extensions to the classical diagnosis algorithms which help to detect potential problems in a spreadsheet based on user-provided test cases more efficiently. The proposed techniques were integrated into a modular framework for spreadsheet debugging and evaluated with respect to scalability based on a number of real-world and artificially created spreadsheets. An additional error detection exercise involving 24 subjects was performed to assess the general applicability of such advanced spreadsheet debugging techniques for end users.
SYSTEM, METHOD AND APPARATUS FOR OBTAINING SENSITIVE AND SPECIFIC PREDICTIONS FROM DEEP NEURAL NETWORKS

The present disclosure relates to a novel system, method and apparatus for encoding activations generated by a generic deep neural network from an image that can be used in conjunction with memory storage devices for highly sensitive and specific prediction of labels associated images of general objects, scenes or persons. The method and apparatus may involve the use of a processor circuit, for example an application server, for automatically predicting a plurality of labels (e.g., diagnostic indices) from an input image and non-image descriptive information associated with the image, where non-image information may include general descriptors of image content (e.g., ear, chest, skin, face), acquisition modality (e.g., hyperspectral image, magnetic resonance image, x-ray, computed tomography, ultrasound, acquisition parameters) and specific descriptors (e.g., unique name or ID, sex, ethnicity, age, date, disease status). A plurality of image feature vectors are extracted from the spatial bottleneck layer from one or more trained convolutional neural networks. Features are stored in memory along with non-image descriptive data. Features extracted from a new image are matched to features stored in memory based on feature-to-feature distance and constrained by non-image information, in order to predict unknown labels. Where features extracted from images of a specific object, scene or person have been previously stored in memory, features extracted from a new image may be used to form a differential prediction based on previous data.
Method and apparatus for determining the thermal resistance of contaminated heat exchange elements of thermal devices, especially of power plant condensers.

Das Verfahren besteht darin, daß zwei von einem einzigen Kondensatorrohr stammende Vergleichsrohrabschnitte (3; 4), von denen eines (3) im korrodierten und/oder durch mineralische Ablagerungen verkrusteten Zustand belassen und das andere (4) durch Beizen oder sonstige Reinigungsprozeduren in den Neuzustand gebracht wird, in Reihe hintereinander leitend verbunden und von Kühlwasser durchflossen und von außen in je einer Kondensatorkammer (1 bzw. 2) durch Dampfströme gleicher Leistung beheizt werden. Die an den Ein- und Austrittsstellen der Vergleichsrohrabschnitte (3; 4) gemessenen Temperaturen (t1, t2 bzw. t3, t4), die gemessenen Werte des Kühlwassermassenstroms (M˙w) sowie der Dampftemperaturen (tf; tb) und der Wärmeströme (Q˙kf = Q˙kb) in den beiden Kondensatorkammern (1 bzw. 2) gestatten die Ermittlung des thermischen Widerstandes (Rf) der Verkrustungsschicht des für die Untersuchung aus dem Kondensator gezogenen Rohres. Die Einrichtung zur Durchführung des Verfahrens weist zwei Kondensatorkammern (1; 2) zur Aufnahme der Vergleichsrohrabschnitte (3; 4) und einen mit den Kondensatorkammern (1; 2) kommunizierenden Entgasungskessel 11 auf. In einer Kühlwasserleitung (15+5+16) sind vor und nach den Kondensatorkammern (1; 2) Meßkammern (17 bzw. 19, 18) vorgesehen mit Thermoelementen zur Messung der Differenzen der genannten Kühlwasser- und Dampftemperaturen. Zur Messung der Wärmeströme (Q˙kf = Q˙kb) dienen vorzugsweise Präzisionswattmeter. Die Wärmeströme können auch aus der Enthalpiedifferenz des Kühlwassermassenstroms (M˙w) vor und nach den Kondensatorkammern (1; 2) berechnet werden. Die Messung des Kühlwassermassenstroms (M˙w) erfolgt vorzugsweise durch Wägen der in der Zeiteinheit ausgeflossenen Kühlwassermenge.