SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
RESNAFRONT - L'USAGE DE RESSOURCES NATURELLES TRANSFRONTALIÈRES COMME POTENTIEL DE DÉVELOPPEMENT

RESNAFRONT was created out of the need to deal with the problems of border territories (maintaining agriculture and forestry, excessive use of natural resources, decreasing population, poor dissemination of tourism potential and insufficient development of business and roads) by means of joint actions to promote the resources of border areas while introducing parameters for environmental and territorial sustainability. The partners in the project are border regions with differing degrees of development and natural resources of acknowledged value. Our objective is to transform characteristics that in themselves seem to be a disadvantage into factors for development of areas of action and for the regions as a whole. Overall objective / Objectif général The general aim of this project is to achieve social and economic development of the areas sharing cross-border natural resources in which development can be improved by drawing up common strategies. The project aims to take advantage of the experience obtained from the Regional Development Programmes in the partner regions, all of which are Objectives 1 and 2. Expected results / Résultats attendus • Increased knowledge of shortcomings and potential of the territories involved by carrying out SWOT analysis (strengths, weaknesses, opportunities, threats) for each of the territories covered by the project. • Drafting of a Joint Development Strategy for application to territories having similar characteristics. • Sharing experiences in joint management of shared natural resources, especially in environment, land planning, rural development and agricultural industries, socio-economic development and tourism. • Improved quality of life in the areas involved. • Protection of the environment and of biodiversity. • Increased cooperation amongst European Union regions.
Uncovering and engineering the principles governing evolution and cellular control of bioenergetic organelles

Complex life on Earth is powered by bioenergetic organelles -- mitochondria and chloroplasts. Originally independent organisms, these organelles have retained their own genomes (mtDNA and cpDNA), which have been dramatically reduced through evolutionary history. Organelle genomes form dynamic populations within present-day eukaryotic cells, akin to individuals co-evolving in a ""cellular ecosystem"". The structure of these populations is central to eukaryotic life. However, the processes shaping the content of these genomes through history, and maintaining their integrity in modern organisms, are poorly understood. This challenges our understanding of eukaryotic evolution and our ability to design rational strategies to engineer bioenergetic performance.

EvoConBiO will address these questions using a unique and unprecedented interdisciplinary approach, combining experimental characterisation and manipulation of organelle genomes with mathematical modelling and cutting-edge statistics. This highly novel combination of experiment and theory will drive the field in a new direction, for the first time uncovering the universal principles underlying the evolution and cellular control of mitochondria and chloroplasts. Our groundbreaking recent work on mtDNA suggests a common tension underlying organelle evolution, between genetic robustness (transferring genes to the nucleus) and the control and maintenance of organelles (retaining genes in organelles). EvoConBiO will reveal the pathways underlying organelle evolution, why organisms adapt to different points on these pathways, and how they resolve this underlying tension. In addition to these ""blue sky"" scientific insights into a process of central evolutionary importance, we will harness our findings to ""learn from evolution"" in high-risk high-reward development of new experimental strategies to engineer chloroplast performance in plants and algae of importance in EU agriculture, biofuel production, and bioengineering.
Determining in vivo protein structures and understanding genetic interactions using deep mutagenesis

The goal of my research is to understand mutations and how they interact to alter phenotypes and disease. We recently initiated a new research direction that uses systematic (‘deep’) mutagenesis to quantify, understand, and predict how diverse mutations interact non-additively within and between molecules to affect phenotypes at multiple scales. Very excitingly, we have also shown that quantifying genetic interactions by deep mutagenesis provides sufficient information to determine the 3D structures of proteins. In this project we will leverage this experience in deep mutagenesis and computational modelling to address three specific aims:

1.	To develop simple generic experimental and computational methods to determine the in vivo structures of proteins using deep mutagenesis and to apply these methods to solve the structures of domains of unknown structure.

2.	To use deep mutagenesis and computational modelling to understand how mutations globally interact within and between molecules, when these interactions can – and cannot – be predicted from phenotypic measurements alone, and how these interactions alter in response to changes in gene expression.

3.	To use deep mutagenesis to understand the cellular toxicity of pathological prion-like domains and to reveal the in vivo structures of these ‘unstructured’ regions, as well as those of disordered proteins that function as agents of protein-based epigenetic inheritance. 

Taken together, this will provide rich insights into how mutations combine to alter phenotypes, a question of central importance to evolution, engineering, and human disease.  It will also develop methods that use deep mutagenesis to determine protein structures, including of intrinsically disordered proteins relevant to disease and epigenetic inheritance.  Our goal is to develop techniques that will allow labs across the world to use deep mutagenesis to solve protein structures, including potentially in large-scale systematic projects.
USE OF THE 7F4 PROTEIN IN THE IN VITRO DIAGNOSIS OF MYCOPLASMA PNEUMONIAE INFECTIONS

The invention relates to the use of the 7F4 protein, having polypeptide sequence SEQ ID No 2, or of fragments or variants of said protein, or the use of the sequences encoding said proteins, in the field of the in vitro diagnosis of a Mycoplasma pneumoniae infection.
Cost effective neural technique for alleviation of urban flood risk

The project will develop a radically new market ready approach to RTC of sewer networks with the aim of reducing local flood risk in urban areas. Existing RTC pilot projects (e.g. Vienna, Dresden, Aarhus) are characterised by complex sensor networks, linked to centralised control systems governed by calibrated hydrodynamic modelling tools and fed by radar rainfall technology. Such systems are expensive and complex to install and operate, requiring a high investment in new infrastructure, communication equipment and control systems. In contrast, this proposal will develop a novel low cost de-centralised, autonomous RTC system. It will be installed, tested and demonstrated in a number of pilot study catchments. This RTC system will utilise data driven distributed intelligence combined with local, low cost monitoring systems installed at key points within existing sewer infrastructure. The system will utilise mechanically simple, robust devices to control flow in order to reduce flood risk at vulnerable sites. This system will be informed and governed directly by sensors distributed within the local network, without the need for an expensive hydrodynamic model or real time rainfall measurements. This system will deliver many of the benefits of RTC systems, whilst avoiding the high costs and complex nature of extensive sensor networks, centralised control systems, communications systems and infrastructure modifications. It is anticipated that such a system will be of significant benefit to operators of small to medium sized sewer networks.
CMP PROCESS FLOW FOR MEMS

The present invention generally relates to the formation of a micro-electromechanical system (MEMS) cantilever switch in a complementary metal oxide semiconductor (CMOS) back end of the line (BEOL) process. The cantilever switch is formed in electrical communication with a lower electrode in the structure. The lower electrode may be either blanket deposited and patterned or simply deposited in vias or trenches of the underlying structure. The excess material used for the lower electrode is then planarized by chemical mechanical polishing or planarization (CMP). The cantilever switch is then formed over the planarized lower electrode.
Apresentação - Dossiê "Estudantes da Universidade, narrativas e relação com o saber"

Este dossiê temático denominado “Estudantes da universidade, narrativas e relação com o saber” é uma das atividades da rede de colaboração, no Brasil coordenada por Rosemeire Reis Universidade Federal de Alagoas - Brasil, na Argentina, por Soledad Vercellino, das Universidades Nacionais de Comahue e Rio Negro (Argentina); na França por Valérie Melin, na Universidade de Lille. Esta parceria baseia-se num interesse comum em torno da investigação teórico-metodológica sobre a relação com o saber das juventudes e pessoas adultas estudantes da universidade, a partir das narrativas para pesquisar os sentidos atribuídos às diferentes dimensões da vida universitária. O dossiê amplia e potencializ os diálogos sobre essa temática de pesquisa, mediante a socialização de produções teóricas e estudos empíricos que contribuem para reflexões sobre possibilidades e limites dos estudos com as narrativas para investigar a relação com o mundo, com os outros e com si mesmos de estudantes universitários/as em contextos políticos, econômicos, históricos e culturais de diferentes países. É composto por duas importantes entrevistas: a primeira com um dos principais expoentes da teoria da relação com o saber, Prof. Bernard Charlot (Universidade Federal de Sergipe). A outra entrevista, com a fundadora da pesquisa biográfica em educação na França, a Profa. Dra. Christine Delory-Momberger e, também, por treze artigos de renomados pesquisadores/as do Brasil, Argentina, México e da França. Os artigos que integram o dossiê são organizados em dois grandes grupos: por um lado, uma série de estudos que incidem sobre os sentidos atribuídos às diferentes dimensões do percurso universitário, com seus desafios subjetivos e objetivos, que incidem em processos identitários de jovens e pessoas adultas, na construção de si como estudantes. E, por outro lado, investigações que exploraram o valor heurístico das noções de relação com o saber e investigação narrativa, em suas diferentes vertentes, para o estudo da formação de professores e em relação a certos conhecimentos didáticos e disciplinares.
Environmental conditions in homes with healthy and unhealthy schoolchildren in Beijing, China

Abstract In 2013, a comprehensive investigation of environmental conditions was carried out in schoolchildren's houses during winter and summer in Beijing, China. The houses were divided into two Groups (Group A: unhealthy children's houses; Group B: healthy children's houses). According to the field measurement, inappropriate thermal environment contributed by indoor low temperatures and RHs in winter and dampness in summer could affect childhood health. The beyond standard (1000 ppm) situations of CO2 concentration revealed poor ventilation in houses of Group A, which could increase the risk of children's asthma and respiratory infections. Indoor carbonyls and VOCs levels in almost all the homes did not exceed the guideline. However, the integrated influence of these compounds should be noted for possible adverse health effects, especially in child's bedroom where children spent more time. Dibutyl phthalate (DBP) and Di (2-ethylhexyl) phthalate (DEHP) were most frequently detected SVOCs in house dust. In summer, the average child's daily intake of phthalates from house dust in homes of Group A was significantly higher (p
Governance of built-heritage in a restrictive political system: The involvement of non-governmental stakeholders

Abstract Built-heritage conservation has increasingly become Hong Kong people's urgent concern since the years leading up to the territory's change of sovereignty from Great Britain to China, under political rules in which development takes priority over conservation. Built-heritage is a symbol of cultural identity and thus Hong Kong people's awareness of the importance of preserving them (Henderson, 2008). NGOs' sense of urgency in getting involved in built-heritage conservation also stems from operating within a political system which Scott (2010) describes as having a restrictive policy-making process, lacking in responsiveness to public demands and expectations. NGOs have three basic functions, namely, service provision, advocacy, and monitoring. Two case studies are used to illustrate these functions. The findings indicate that NGOs are most intensely involved in advocacy. NGOs involved in service provision have been selected through tightly-controlled processes. NGOs' monitoring activities were very limited. I argue that NGOs' role in built-heritage conservation is limited due to the restrictive political system. However, NGOs demonstrated insistent and resilient opposition to any top-down approach to decision-making, a sign that leads to the belief that despite of and because of the nature of the political system, NGOs' involvement in built-heritage is not only likely to intensify but also expand with government increasing the openness of the policy process to contain public pressure.
Learning and adaptation of a policy for dynamic order acceptance in make-to-order manufacturing

Order acceptance under uncertainty is a critical decision-making problem at the interface between customer relationship management and production planning of order-driven manufacturing systems. In this work, a novel approach for simulation-based development and on-line adaptation of a policy for dynamic order acceptance under uncertainty in make-to-order manufacturing using average-reward reinforcement learning is proposed. Locally weighted regression is used to generalize the gain value of accepting or rejecting similar orders regarding attributes such as product mix, price, size and due date. The order acceptance policy is learned by classifying an arriving order as belonging either to the acceptance set or to the rejection set. For exploitation, only orders in the acceptance set must be chosen for shop-floor scheduling. For exploration some orders from the rejection set are also considered as candidates for acceptance. Comparisons made with different order acceptance heuristics highlight the effectiveness of the proposed ARLOA algorithm to maximize the average revenue obtained per unit cost of installed capacity whilst quickly responding to unknown variations in order arrival rates and attributes.
Bioactive coatings in multi-well cell culture plates

Cell culture is a method used for growing living cells artificially outside their natural environment under controlled conditions. It is used for a large range of applications such as studies of cellular functions, drug discovery, biotechnologies and regenerative medicine. Cell culture in vitro is generally performed on plastic substrates, especially multi-well plates or Petri dishes that are made of polystyrene, a very stiff and synthetic material. This stiff substrate can bias the experimental results and mask cellular responses. These culture conditions contrast drastically with the conditions of the cellular microenvironment in vivo, where the cells are surrounded by a soft extra-cellular matrix (ECM) that provides mechanical and biochemical signals. 
Bioengineers have recently made developments on hydrogels and surface coatings that better mimic the natural ECM and present: 1) a controlled stiffness in a more physiological range than plastic dishes and 2) active biomolecules (peptides, growth factors) that can target specific receptors and trigger cellular responses. 
However, to date, there are still very few commercially available alternatives to the traditional plastic plates for high throughput cell culture in more relevant conditions. Hydrogel-coated plates have begun to be developed but lack stability in time and are highly sensitive to hydration.
The aim of the BioActiveCoatings project is to bring to the market surface-coated plates with a control over thickness, stiffness and presentation of bioactive molecules (peptide, growth factor). This innovative strategy based on the layer-by-layer assembly of biopolymers will be implemented on multi-well plates, which are compatible with biological assays and optical microscopy. The Lbl-coated multi-well plates will broaden the application of cell culture plates in research and industry for fundamental biological studies, production of biological molecules, diagnosis and regenerative medicine.
Building social and emotional skills to boost mental health resilience in children and young people in europe

It is widely documented that social and emotional learning (SEL) programs are effective in promoting mental health and well-being in children and young people. However, a number of shortcomings of these programs have been identified, which may compromise their sustainability and long-term effect. The BOOST project will go beyond state of the art of current SEL programmes and develop an approach to integrate SEL in teachers' pedagogical skills and classroom interaction and a tool for organisational development to facilitate implementation and uptake of the approach in classrooms, schools and among school owners (the BOOST approach). The development will involve the young themselves, as well as school owners, teachers, policy makers and a multidisciplinary team of researchers from fields of education, public health, psychology and economics. This is to ensure the relevance, acceptability and organisational and political anchoring of the intervention, as well as to increase the potential for scale-up and sustainability of the intervention locally, regionally, nationally and internationally. The end users of the BOOST approach are schools and teachers, but the target population are children and young people. To ensure the relevance of the BOOST approach in a wide range of European contexts, the approach will be developed, implemented and tested in three diverse European settings, Poland, Spain and Norway. The BOOST approach will be evaluated for its short-term and long-term effects on children's social and emotional well-being, as well as for its economic benefits.
Detecting Essential Oil Adulteration

An upsurge in worldwide essential oil sales seems to have intensified corrupt practices by unscrupulous costcutters and adulterators with varying levels of expertise. From outright misrepresentation of botanical species to the addition of cheaper oils to create additional profit for the oil producer, adulteration is unfortunately a common place occurrence in essential oil trade. The most adulterated essential oils fall into two categories: high-value oils like sandalwood and rose and the bestselling oils such as lavender, peppermint, citrus oils, wintergreen, oregano, and thyme. While some adulterations can be detected simply by routine GC-MS testing, with technology such as GC-IRMS and SNIF-NMR, analysts are able to spot adulteration with synthetic compounds or the natural compounds and/or oil fractions taken from cheaper essential oils. Today’s cutting-edge technology for essential oil adulteration detection encompasses many analytical techniques from HPLC and fast GC to GC × GC, IRMS to MS, 1H, and 13C NMR. This paper is a review of 30 studies dating up to May 2014 that detail the analytical procedures used to uncover essential oil adulteration in order to ensure that essential oils are authentic and genuine.
Discrimination of older people in Serbia

Abuse of older people is a single or a repeated act or a failure to act happening in a relationship between two persons based on trust that causes pain or disturbance on the part of the older person. Red Cross of Serbia is the initiator and the founding member of Humanas (the network of 15 civil society organisations dealing with the issues of older people) and is spearheading a campaign of sensitisation of the public in relation to discrimination, neglect and abuse of older people. Humanas has educated volunteers in Elder Abuse and Discrimination prevention. A survey has been done in 8 cities in Serbia polling 250 older people of both sexes, age 65 or above. The survey results demonstrate that 44% of all the polled people are familiar with the existence of abuse. Alarmingly, as high as 32% of older people have been exposed to some form of abuse, with the most frequent form being verbal abuse (11.2%) The polled older people have stressed that they hate being called names, made fun of and called stupid or illiterate, within their families as well as in the general community. As for prevention, 52% of the polled older people think that ‘everybody’, meaning both public and civil sector should play a role in prevention. Conclusion The problem of abuse of older people has to be approached from a multi-sector and multi-disciplinary perspective. The emphasis should be on new, deeper surveys, education of professionals, family members and other care takers.
Multiscale simulation of xenon diffusion and grain boundary segregation in UO2

Abstract In light water reactor fuel, gaseous fission products segregate to grain boundaries, resulting in the nucleation and growth of large intergranular fission gas bubbles. The segregation rate is controlled by diffusion of fission gas atoms through the grains and interaction with the boundaries. Based on the mechanisms established from earlier density functional theory (DFT) and empirical potential calculations, diffusion models for xenon (Xe), uranium (U) vacancies and U interstitials in UO2 have been derived for both intrinsic (no irradiation) and irradiation conditions. Segregation of Xe to grain boundaries is described by combining the bulk diffusion model with a model for the interaction between Xe atoms and three different grain boundaries in UO2 ( Σ 5 tilt, Σ 5 twist and a high angle random boundary), as derived from atomistic calculations. The present model does not attempt to capture nucleation or growth of fission gas bubbles at the grain boundaries. The point defect and Xe diffusion and segregation models are implemented in the MARMOT phase field code, which is used to calculate effective Xe and U diffusivities as well as to simulate Xe redistribution for a few simple microstructures.