SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
New roles for the cytoskeleton in cell-autonomous immunity to mycobacteria

Cell-autonomous immunity is the ability of a host cell to eliminate an invasive infectious agent. Recent work has shown that components of the cytoskeleton have a major role in cell-autonomous immunity and control of bacterial infection. The Mostowy group has shown that some intracellular bacteria, including Shigella flexneri and Mycobacterium marinum, can escape from phagosomes and invade the host cell cytosol where they interact with cytoskeleton components to form actin tails or be entrapped in septin cage-like structures. However, our knowledge of these interactions derives from a limited number of in vitro studies, and has not been fully characterized in vivo during a disease-causing infection. M. marinum, a species closely related to the human pathogen M. tuberculosis, can be applied as a paradigm to understand the cell biology of mycobacterial infection. Zebrafish is naturally susceptible to M. marinum and, as I have shown during my PhD, can be used as an important animal model to gain in-depth information about the innate immune response to bacterial infection. Using state-of-the-art genome editing tools and high resolution microscopy techniques, I will study M. marinum interactions with the cytoskeleton, and investigate the role of these interactions in cell-autonomous immunity. Using M. marinum, my specific objectives are: 1) to identify and characterize host and pathogen determinants affecting autophagy-cytoskeleton interactions, and 2) to investigate the discovered molecules and mechanisms in vivo using the zebrafish model. A more comprehensive understanding of M. marinum-cytoskeleton interactions will have important consequences for enhancing host defense and fighting antimicrobial resistance. This should provide vital clues towards new strategies aimed at combating infectious diseases, and possibly other human diseases that arise from a dysfunctional host response.
Family to the montagne between nature and culture

This project is born from the sharing of a commune strategy of development of both territories: Morgex and Le Grand-Bornand, both localities of Mountains in which the touristic sector has a primordial economic and social role, but where the main touristic flux is concentrated on the winter period, and a short summer period. This tourism is often disconnected of vital sectors of the mountain economy, as agriculture or handicraftsmen. It a double cross-border observation from one hand it’s the weakness of the current mountain offer of winter sports, in another hand, the mountain is often unknown and seen as non-adapted to familial activities. 
In front of a sectored and consumerist tourism, the aim is to purpose alternative solutions which allow to visitors to take over these new spaces and a new relation thanks to the mobilisation of the five senses. 
The project purpose to reinforce and diversify the touristic offer with the combination of nature and culture with the access to the mountain and the reading, an offer under-developed until today in mountain touristic destinations.
Developing a public information and engagement portal of urban waterways with real-time monitoring and modeling

Waterways can contribute to the beauty and livelihood of urban areas, but maintaining their hydro-ecosystem health is challenging because they are often recipients of contaminated water from stormwater runoff and other discharges. Public awareness of local waterways’ health and community impacts to these waterways is usually poor due to of lack of easily available information. To improve community awareness of water quality in urban waterways in New Zealand, a web portal was developed featuring a real-time waterways monitoring system, a public forum, historical data, interactive maps, contaminant modelling scenarios, mitigation recommendations, and a prototype contamination alert system. The monitoring system featured in the web portal is unique in the use of wireless mesh network technology, direct integration with online modelling, and a clear target of public engagement. The modelling aims to show the origin of contaminants within the local catchment and to help the community prioritize mitigation efforts to improve water quality in local waterways. The contamination alert system aims to keep managers and community members better informed and to provide a more timely response opportunity to avert any unplanned or accidental contamination of the waterways. Preliminary feedback has been positive and is being supported by local and regional authorities. The system was developed in a cost-effective manner providing a community focussed solution for quantifying and mitigating key contaminants in urban catchments and is applicable and transferable to other cities with similar stormwater challenges.
The role of simulated small-scale ocean variability in inverse computations for ocean acoustic tomography

Ocean acoustic tomography depends on a suitable reference ocean environment with which to set the basic parameters of the inverse problem. Some inverse problems may require a reference ocean that includes the small-scale variations from internal waves, small mesoscale, or spice. Tomographic inversions that employ data of stable shadow zone arrivals, such as those that have been observed in the North Pacific and Canary Basin, are an example. Estimating temperature from the unique acoustic data that have been obtained in Fram Strait is another example. The addition of small-scale variability to augment a smooth reference ocean is essential to understanding the acoustic forward problem in these cases. Rather than a hindrance, the stochastic influences of the small scale can be exploited to obtain accurate inverse estimates. Inverse solutions are readily obtained, and they give computed arrival patterns that matched the observations. The approach is not ad hoc, but universal, and it has allowed inverse estimates for ocean temperature variations in Fram Strait to be readily computed on several acoustic paths for which tomographic data were obtained.
An inquiry into the foundations of perceived inequality

Rising levels of inequality has become a key political, economic and social issue in recent years. Nevertheless, many studies show that individuals are much more likely to be influenced by subjective rather than objective inequality. For such reason, perceived inequality is becoming an increasingly popular topic among scholars and non-academic experts. Despite the growing number of studies, little is still known about what perceived inequality is exactly and how it can properly measured given that it is a contested, multidimensional and unobservable concept (1 research objective). Moreover, it is still not clear why people wrongly assess it and which are the consequences of such misperception (2 research objective). The first research objective aims at contributing to a general theory of perceived inequality defining perceptions within models of human behaviors through an interdisciplinary review of the literature. Moreover, improved measures of perceived inequality will be elaborated applying cluster analysis to multiple indicators.  The second objective of the research focuses on the identification of the main causal mechanisms driving inequality misperceptions (limited rationality or emotional innumeracy) and its consequences in our society. Such objective is pursed through the creation of an original questionnaire and the implementation of a survey experiment for the collection of new data. Doing so, the simultaneous test of the two causal mechanisms can be implemented for the first time in the literature of perceptions of inequality. The survey will also allow to explore the political and economic consequences of misperceiving inequality. When considering political consequences, the research focuses on political unrest and populist voting (e.g., Brexit, Trump, Lega Nord in Italy); while for economic consequences, it focuses on preferences for redistribution. Important policy implications for our knowledge-based society are expected from PERCINEQ.
Educational Innovation in the Computer Architecture Area

Abstract In the present work authors give a detailed description of the previously performed analysis carried out to formulate a concrete educational innovation project proposal in the area of the Computer Architecture, more specifically, in the Computer Structure and Architecture sub-module. That project was submitted to the competitive Educational Innovation Projects Call 2013-2015 of the Basque Country University (UPV/EHU, Spain), and fortunately, it was elected and granted by the Education Advisory Service of the same university. This project follows the the way started by another similar project but in other knowledge area of Electronics in the same University College. In this paper, the specific problems of the Computer Structure and Architecture sub-module in the University College of Vitoria-Gasteiz (that is the place where it is being carried out) are analyzed, the framework in a wide sense is described (University, University College and syllabus) and the specificities of the current project are explained. All the analysis is done taking into account the competences point of view (both specific for each subject and transversal for the degree).
Augmenter la capacité d’une usine d’éléments pro-fabriqués pour la construction, dans le cadre de processus de production innovants liés à un système de modélisation de l’information sur le bâtiment (BIM).

Le projet d’investissement vise à accroître la capacité d’une unité industrielle de fabrication d’éléments pro-fabriqués en pliage, grâce à la mise en œuvre la plus efficace de la machine et à un système de modélisation de l’information sur le bâtiment (BIM) avec les attributs de l’industrie 4.0.
The diagnostic values of preoperative laboratory markers in children with complicated appendicitis

Accurate diagnosis and optimal management of acute appendicitis, despite being the most common surgical emergency encountered in emergency departments, is often delayed in pediatric patients due to nonspecific symptoms and communication barriers, often leading to more complicated cases. The aim of this study is to investigate the diagnostic significance of common laboratory markers.A total of 421 patients aged 15 and younger underwent surgical treatment for acute appendicitis. We conducted a retrospective analysis for white blood cell (WBC), C-reactive protein (CRP) and bilirubin. All patients were classified into simple or complicated appendicitis groups based on postoperative histology.The mean age of the patients in the complicated appendicitis group was younger than that in the simple group (P = 0.005). WBC, CRP and bilirubin levels were significantly higher in the complicated appendicitis group (P < 0.001, <0.001, 0.002). The relative risk for complicated appendicitis was calculated using age, WBC, CRP and bilirubin. Elevated CRP levels were associated with the highest risk for complicated appendicitis (hazard ratio [HR], 2.53; 95% confidence interval [CI], 1.38 to 4.65) followed by WBC (HR, 2.42; 95% CI, 1.07 to 5.46) and bilirubin (HR, 2.04; 95% CI, 1.09 to 3.82). The most sensitive markers for diagnosing complicated appendicitis were WBC (95.2%) and CRP (86.3%). Bilirubin levels showed the highest specificity at 74.8%.The risk of complicated appendicitis was significantly higher in patients younger than 10 years old. Preoperative WBC, CRP and bilirubin have clinical value in diagnosing complicated appendicitis with a HR of 2.0 to 2.5. Our results suggest that the utilization of WBC, CRP, and bilirubin can assist in the diagnosis of complicated appendicitis in pediatric patients, allowing prompt diagnosis and optimal management.
Quality of Care for Patients with Type 2 Diabetes Mellitus in Dubai: A HEDIS-Like Assessment

Objective. As little data are available on the quality of type 2 diabetes mellitus (T2DM) care in the Arabian Gulf States, we estimated the proportion of patients receiving recommended monitoring at the Dubai Hospital for T2DM over one year. Methods. Charts from 150 adults with T2DM were systematically sampled and quality of care was assessed during one calendar year, using a Healthcare Effectiveness Data and Information Set- (HEDIS-) like assessment. Screening for glycosylated haemoglobin (HbA1c), low-density lipoprotein (LDL), blood pressure, retinopathy, and nephropathy was considered. Patients were classified based on their most recent test in the period, and predictors of receiving quality care were examined. Results. Mean age was 58 years (standard deviation (SD): 12.4 years) and 33% were males. Over the year, 98% underwent HbA1c screening (50% had control and 28% displayed poor control); 91% underwent LDL screening (65% had control); 55% had blood pressure control; 30% had retinopathy screening; and 22% received attention for nephropathy. No individual characteristics examined predicted receiving quality care. Conclusion. Some guideline monitoring was conducted for most patients; and rates of monitoring for selected measures were comparable to benchmarks from the United States. Greater understanding of factors leading to high adherence would be useful for other areas of preventive care and other jurisdictions.
Project selection with limited resources in data envelopment analysis

In this paper allocating a fixed resource for producing finite projects in order to obtaining a desired level of efficiency will be discussed. Note that it is assumed that a vector of limited sources is at hand. This vector of resources can be contained human resource, budget, equipment, and facilities. In any firm there exist different suggestions from subunits for running a new projects in line with the organization’s objectives. Implementation of all the suggested projects need high level of resources. In accordance to this fact that resources are limited thus it is not possible to run all of the projects. Thus, selecting high quality projects or those with high efficiency is more desirable for implementation. In this paper a method for selecting projects will be proposed which has high performance.
Utilization of minimum quantity lubrication (MQL) with water in CBN grinding of steel

The use of cutting fluids is fundamental to machining processes, mainly when it comes to high heat generation, which is the case of grinding. Thus, lubrication and cooling provided by cutting fluids improve the final quality of the workpiece. However, cutting fluid usage provide some drawbacks concerning environmental, costs and health issues. Therefore, new methods for application and optimization of cutting fluids are being researched aiming to reduce the amount of fluid used, as well as the minimization of cutting fluid hazards. The present study analyzes the behavior of a recently proposed optimization method, up to now only tested in turning, which consists of adding water to minimum quantity lubrication (MQL). Three different proportions were tested in this study: 1/1, 1/3 and 1/5 parts of oil per parts of water. The following output variables were evaluated: surface roughness, roundness errors, grinding power and diametric wheel wear. Also, optical microscopy and microhardness measurements were conducted, in order to detect burns and surface alterations. The obtained results were also compared to conventional (flood coolant) cooling-lubrication and traditional MQL (without water). MQL with water (1/5) presented better results of surface roughness and roundness errors, when compared to traditional MQL, and the results are very close to when using flood coolant. For grinding power and wheel wear, the results for MQL with water (1/5) were the best among the tested conditions.
Risky or Needy? Dynamic Risk Factors and Delinquent Behavior of Adolescents in Secure Residential Youth Care

Although it is known that adolescents in secure residential care often show multiple behavior problems, it is largely unknown which dynamic risk factors are associated with their problems. The aim of the present study is to examine dynamic risk factors for 164 Dutch adolescents in secure residential care. Results show that a majority reports multiple risk factors in both an individual and contextual domain but that about a fifth shows relatively few risk factors. Substance abuse and delinquent friends were among the five most prevalent risk factors and predicted the seriousness of the adolescents’ delinquent behavior prior to admission. The four groups that were found by cluster analysis could be distinguished by problem type and seriousness. The findings indicate that treatment for some adolescents should be mainly focused on their individual needs, while other adolescents need intensive, multimodal treatment focusing on both risks in the individual, family, and peer domains.
Selectivity of 90Sr urine bioassay technique over 241Am, 238/239PU, 210PO, 137CS and 60CO

The selectivity of a rapid (90)Sr bioassay technique over (241)Am, (238/239)Pu, (210)Po, (137)Cs and (60)Co has been investigated. Similar to (90)Sr, these radionuclides are likely to be used in radiological dispersive devices. The purpose of this study was to demonstrate the degree to which the (90)Sr bioassay technique is free from interference by these radionuclides if present in a urine matrix. The interfering radionuclides were removed (from (90)Sr) by their retention on an anion exchange column. While, recovery of the target radionuclide ((90)Sr) was found to be >or= 90 %, contributions from (241)Am, (242)Pu and (208)Po were found to be <or= 3 % indicating minimal interference from these radionuclides. The breakthrough for (60)Co, however, was found to be <or=19 % indicating that it will have some interference contribution to the (90)Sr measurement if present in the urine sample. As (137)Cs was not retained at all by the anion exchange column, the method as such was not selective over (137)Cs. However, a slight modification of the method through the ammonium molybdophosphate treatment quantitatively removed Cs from the urine sample, thereby; making it selective for (90)Sr despite any (137)Cs that is present.
Three-body system metaphor for the two-slit experiment and Escherichia coli lactose–glucose metabolism

We compare the contextual probabilistic structures of the seminal two-slit experiment (quantum interference experiment), the system of three interacting bodies and Escherichia coli lactose–glucose metabolism. We show that they have the same non-Kolmogorov probabilistic structure resulting from multi-contextuality. There are plenty of statistical data with non-Kolmogorov features; in particular, the probabilistic behaviour of neither quantum nor biological systems can be described classically. Biological systems (even cells and proteins) are macroscopic systems and one may try to present a more detailed model of interactions in such systems that lead to quantum-like probabilistic behaviour. The system of interactions between three bodies is one of the simplest metaphoric examples for such interactions. By proceeding further in this way (by playing with n -body systems) we shall be able to find metaphoric mechanical models for complex bio-interactions, e.g. signalling between cells, leading to non-Kolmogorov probabilistic data.
Celiac Disease and HLA Molecular Typing

Faustina Barbara Cannea1, Rossano Rossino2 and Alessandra Padiglia1* Author Affiliations 1Dipartimento di Scienze della Vita e dell’Ambiente (DiSVA), Biomedical section, University of Cagliari, Cittadella Universitaria di Monserrato, Italy 2Dipartimento di Scienze Mediche e Sanità Pubblica (DSMSP), University of Cagliari, AOU Presidio Microcitemico via Jenner, Italy Received: February 22, 2022 | Published: March 09, 2022 Corresponding author: Alessandra Padiglia, Dipartimento di Scienze della Vita e dell’Ambiente (DiSVA), Biomedical section, University of Cagliari, Cittadella Universitaria di Monserrato, 09042 Monserrato, Cagliari, Italy DOI: 10.26717/BJSTR.2022.42.006754
Sewing shadows : investigating performance research in the primary school curriculum

This thesis recounts the development through fieldwork in primary schools of a distinctive
performance pedagogy that bridges drama and live art. Two inter-connected strands run
through the thesis. First, a praxis in the context of the primary school curriculum involves
the creation of learning spaces through performance work which embrace qualities of
ownership and subjectivity within imaginative and participatory practices. This prompted
a shift from live art to more conventional drama praxis and has special benefits for
disadvantaged and marginalised children. Historically, the thesis sits within Buckingham
and Jones (2001) description of the “cultural turn” towards the creative industries. In the
years following New Labour’s election victory (1997) a number of influential documents
and directives were launched to promote creative learning in schools. The creative agenda
emerged at a time when teachers experienced unprecedented levels of control over, and
public scrutiny of, their everyday working lives; it was a period dominated by a
“bureaucratisation” of education. I have positioned practice in the midst of reform, which
at times appeared to be pulling in opposite directions. Secondly, a conceptual framework
examines the “crisis of representation” (Denzin, 1997) in relation to lived experience and
the written word. Writing often fails to capture the ephemeral nature of the performance
studies agenda. In performance, meaning is found in the moments between thought and
expression and in the silence between words. But, whilst words cannot replicate reality,
writing can offer a deep and long-lasting impression of the world we inhabit. In response
to the crisis of representation the thesis works towards a polyphonous account of the
research process, weaving between performance texts, narrative stories, diary entries and the writing of others. Poststructural and phenomenological perspectives have illuminated
the shifting space between competing discourses and ways of seeing. Above all, this
thesis is the product of work with children, made possible when the desire to imagine
outweighs the reality and actuality of the present.
DEVICE FOR DRILLING HOLES AND/OR SLITS

A device is proposed for drilling holes and/or slits in the vertical and horizontal direction, in particular for drilling holes and/or slits in a stone block. The device comprises a self-propelled crane bridge (2) which runs on tracks and is of full-gantry, half-gantry or bridge design, the support pillars (3, 4) being of variable length. The crane bridge is provided with at least one traveller (9) on which height- and direction-adjustable carriages (11) and drilling tools are fitted.