SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Evolution and function of the germline-restricted chromosome in songbirds

Metazoans typically keep the same genetic information in all body cells over their life cycle. However, some organisms show exceptions to this rule through programmed DNA elimination from the somatic cell line, as it is the case of the puzzling germline-restricted chromosome (GRC) in songbirds. Recently, it has been demonstrated that the GRC is likely present in over half of all bird species and that the zebra finch GRC is enriched in developmental genes. The latter constitutes a novel mechanism for germline-specific gene expression in multicellular organisms, which is of significant relevance to fields as genomics, developmental biology, ecology or even cancer research. However, it remains mysterious how the GRC affects differential gene expression between tissues, the genomic divergence between species, and the determination of cell fate between germline and soma. To elucidate this, we will first perform multiplatform sequencing and high-quality assembly of the GRC in the zebra finch. Then, by comparing somatic and germline genomes from many bird species to infer the evolutionary trajectories of the GRC, we will determine its most ancient and, therefore, important genes. Finally, we will perform a functional analysis to elucidate the role of these genes in primordial germ cells and the early transmission in embryos. Recent technological advances in sequencing, bioinformatics and developmental biology provide us now with a unique moment to perform the proposed multi-omics analyses. Successful and high-quality implementation will be ensured by the extensive experience of the fellow in cytogenetics and genomics of supernumerary chromosomes as well as in developmental biology in zebrafish. In addition, the host lab is expert in cutting-edge multiplatform genomics techniques and has a multidisciplinary network of collaborators, and the secondment partner is expert in experimental biology with zebra finch embryos and primordial germ cell cultures.
Role of aβ specific regulatory t cells in harnessing cerebral aβ clearance in alzheimer’s disease

With populations ageing, Alzheimer’s disease (AD), for which there is still no cure, has become a major public health problem in Europe. This is partly due to the neglect of the role of the immune responses to the build-up of cerebral Aβ-the pathogenic agent triggering AD. Clinical trials for vaccines aimed at reducing cerebral Aβ were accompanied by severe side effects due to improper neuroinflammation.  While the input of microglia, the brain resident innate immune sentinels, is becoming clearer, the impact of the adaptive immune system, specifically T cells is still unknown. A promising therapeutic strategy, would be to strengthen Aβ-induced regulatory T cells (Treg), to alter the effector T cell mediated inflammatory response, while promoting clearance of Aβ by microglia. My interdisciplinary project hosted by Trinity College Dublin and supervised by Prof Lynch will draw together both Neuroscience and Immunology. I propose to assess the effect of Aβ-specific Treg on the pathoethiology of AD. To this aim, I will amplify a population of Aβ-specific Treg in the APP/PS1 mouse model of AD and will 1) assess if Aβ-specific Treg can regulate instruction of microglia to clear cerebral Aβ, while keeping inflammation under control, 2) determine if this regulatory effect occurs via paracrine mechanisms from the periphery or if Treg physically enter the CNS and 3) identify other Aβ-specific T cell populations involved in response to cerebral Aβ build-up and in alteration of microglial phagocytic activity. Completion of this project will make a critical contribution to the understanding of the immune response in AD and will pave the way towards safer therapeutic tools. 
The proposed action will allow the dissemination of my work to both neuroscientists, immunologists, and the general public. I will reinforce my multidisciplinary and inter-sectoral skills, improve my management and teaching experience to establish myself among the leaders of research at ERC level.
A computational framework to interpret the chemical language of the microbiome

Humans, animals and plants are covered in microbes. Such microbiomes have a major impact on the health of their hosts and have been linked to traits like growth promotion, stress resilience, and diseases. However, the mechanisms underlying microbiome-host interactions remain poorly understood. Recent studies have shown that microbiome-associated phenotypes are often mediated by specific molecules, a ‘chemical language’ that enables microbes to interact with each other and with the host. The biosynthesis of these molecules is encoded in metabolic gene clusters (MGCs) that are subject to frequent horizontal transfer and are therefore highly strain-specific.
Current computational methods for analysing microbiomes largely focus on comparative taxonomic analyses and generic metabolism, and overlook this complex ""chemical dialog"". Indeed, no adequate methods are available to systematically study the roles of MGCs in microbiomes. At the same time, metabolomics data from microbiomes are full of ‘dark matter’: unknown molecules that cannot be traced to their producers. Here, I propose to develop the first comprehensive computational framework to study the chemical language of the microbiome.
In the past years, I have developed technologies that lay the foundation for this ERC project, including automated identification of MGCs, grouping them into families and annotating them using reference data. With DECIPHER, I will move my research to the next level, by developing new algorithms to link MGCs to their metabolic products and to predict their molecular and ecological functions in microbiomes. I will then apply this new framework in a systematic study of microbiome- associated phenotypes in plants and humans. Together, the innovations proposed here will fill a key gap in the analysis of microbiome function and pave the way toward precision-engineering of microbiomes with specific metabolic capabilities for designer soils and microbiome-based therapies.
Codes and methods improvements for vver comprehensive safety assessment

VVER reactors constitute a significant and dynamic part of the European energy market. The safe LTO of VVER (maintenance, refuelling, safety-upgrade, revamping) is based on the industrial use of neutronics and thermal-hydraulics codes and methods that allow studying the behaviour of the plant in normal and accidental conditions. The objective of CAMIVVER project is to develop and improve codes and methods for VVER comprehensive safety assessment.  Such development is strongly required for the following reasons:  

1) Current codes and methods used for VVER safety assessment are subjected to international export controls from outside EU. Export controls from major countries have increase in the last years, threatening the EU sovereignty and security in terms of energy supply. 

2) A new generation of innovative codes and methods are being developed within Europe. These new codes and methods are improving 3D-multiphysics modelling capabilities, and uncertainty quantification capabilities. These codes and methods are worth being transferred from lab to industry as they will substantially improve the physics comprehension of PWR and VVER behaviour. 

3) European codes and methods development for VVER safety assessment will open the VVER market to the European nuclear industry and will support a free and fair competition on this market. To achieve this objective, CAMIVVER will perform developments required for the new generation codes to be fully applied on VVER scope (and to PWR scope too), CAMIVVER will generalise 3D-multiphysics coupling, CAMIVVER will perform experimental validation and benchmark against current industrial codes used for VVER safety assessment, and CAMIVVER will demonstrate CFD utility and compatibility with uncertainty propagation in the frame of a safety assessment. 

Finally, CAMIVVER will provide guidance to European Safety Authorities, to VVER operators, and to the international research community, concerning the use of these innovative approaches of codes and methods development.
Joint and marginal probabilities for time of arrival and angle of arrival using ellipsoidal model

In this paper, time of arrival and angle of arrival statistics for wireless propagation environments are evaluated in closed form using three dimensional ellipsoidal model. Scatterers are assumed to be uniformly distributed inside the ellipsoid whose foci collocate with the transmitter and the receiver. This model finds numerous applications in micro- and pico-cell outdoor as well as for indoor environments where scatterers significantly impact the transmitter and receiver characteristics. Joint and marginal probability density functions of time of arrival and angles (both azimuth and elevation) of arrival at the receiver side are evaluated in closed form. Numerical simulations are used to validate the analytical derivations.
Mobilizing Victim Services: The Role of Reporting to the Police

Victim assistance programs have grown dramatically in response to the victim's rights movement and concern over difficulty navigating victim services. Evidence, however, indicates that very few victims seek assistance. The present study examined factors associated with victim service use including reporting to the police, the victim's demographic characteristics, the victim's injury, offender's use of a weapon, the victim's relationship to the offender, and the victim's mental and physical distress. Data came from a subset of the National Crime Victimization Survey 2008-2011 (N = 4,746), a stratified multistage cluster sample survey of persons age 12 years and older in the United States. Logistic regression models indicated that fewer than 10% of victims of violent crime sought help from victim services. Reporting to the police increased the odds of seeking services by 3 times. In addition, the odds of victims attacked by an intimate partner seeking services were 4.5 times greater than victims attacked by strangers. Findings suggest that additional exploratory work is needed in uncovering the mechanism of police involvement in linking victims to services. Specifically, do police understand what services are available to victims and why are police more likely to inform some types of victims about services more than others?
New approach to wearable devices wireless performance testing

Wearable devices, such as smart glasses, smart watches, hearables, fitness and health trackers or even smart fashion, are noticeably starting to take an important role among our everyday technology. Thousands of new devices are launched every year and the trend is expected to accelerate in the coming years.

As the market grows, more companies are engaging in the business and developing their own devices. To keep their products competitive, time-to-market, product quality and performance are becoming critical factors for the developers, and repetitive performance testing during the R&D cycle is necessary to achieve an advantage. However, there are very few professional testing services on the market for wearable devices, and developers are forced to conduct time-consuming and expensive wired field tests on their own.

Verkotan Oy is a Finnish testing house that has created a novel, accurate and versatile method and measurement environment for wearable devices’ wireless performance measurements, benchmarking and competitor analysis using Over the Air (OTA) testing. The new method remarkably shortens testing cycles, cuts the product development time and saves on average €100,000-200,000 per project for the developers.

The WearMark project helps Verkotan to assess the business potential and economic feasibility of the proposed innovation, and focuses on:
• Creating a Business plan to define the best strategy for the commercialization of the method; 
• Conducting a freedom-to-operate study to ensure no other patents are infringed by the proposed project; 
• Technical feasibility assessment of the OTA test environment on Healthcare & Medical, Sports, and Industrial Smart Clothing wearables categories.

The global retail revenue from wearables is expected to reach €49.4 billion by 2019 compared to €4.2 billion in 2014, and the market of wearables testing is expected to emerge in a similar way. The expected annual turnover of Verkotan reaches €32 million by 2021.
STEUERGUTSCHRIFT – FRUCHTFÜHRER VON F.LLI LANZAFAME S.R.L.

SIND SIE AKTIV? EINZELHANDEL UND GROSSHANDEL MIT OBST UND GEMÜSE. REALISIERUNG EINER FRIGORIFERADESTINATA-STRUKTUR SOWOHL BEIM VERKAUF VON
LOW PILL POLYESTER

New polyester composition for new polyester staple fiber that provides fabrics having a combination of excellent pilling performance, aesthetics and tactility ("hand"). Preferred fibers have non-round cross sections that are retained, especially such non-round cross sections having multi-grooved scalloped-oval cross sections that provide fabrics having outstanding comfort qualities of moisture-management, dryness and comfort, along with minimal pilling.
Full Scope of Options

The purpose of Clinical Problem Solving articles is to present management challenges to give practicing neurosurgeons insight into how field leaders address these dilemmas. This illustration is accompanied by a brief review of the literature on the topic.The case of a 16-year-old boy presenting with headaches is presented. The patient is found to have a typical colloid cyst at the foramen of Monro. Bilateral ventriculoperitoneal shunt placement had been performed as an initial treatment of the patient before presentation.Surgeons experienced in open and endoscopic surgery discuss their individual approaches to colloid cysts, in the context of previous shunting, providing a varied perspective on the clinical challenges posed by these lesions.Both open and endoscopic options remain viable for excision of a colloid cyst. Each has associated potential complications, as illustrated by the current case.
Financial Determinants of International Remittance Flows to the Sub-Saharan African Region

There is a general belief that Sub-Saharan Africa has the poorest record of international remittances because, due to deficiencies in the region's financial systems, a greater proportion of remittances passes through informal channels. This article examines the interactive impact of financial development on remittances to the region. Using a panel data covering 32 countries in the region from 1995 to 2009, it finds evidence of weak financial infrastructure constraining the flow of remittances. It also shows that the higher the level of a country's infrastructural development, the greater the impact on remittances. The article establishes that the impact of financial development and institutional quality is greater in emerging markets than in developing economies, implying that improving the financial system and institutional structures in Africa should be at the centre of the current policy efforts to optimize the benefits of remittances.
A Demonstration of ALAS-KA: A Learning Analytics Tool for the Khan Academy Platform

AbstractInstructors and students have problems monitoring the learning process from low level interactions in on-line courses because it is hard to make sense of raw data. In this paper we present a demonstration of the Add-on of the Learning Analytics Support in the Khan Academy platform (ALAS-KA). Our tool processes the raw data in order to transform it into useful information that can be used by the students and instructors through visualizations. ALAS-KA is an interactive tool that allows teachers and students to select the provided information divided by courses and type of information. The demonstration is illustrated with different examples based on real experiments data.Keywordslearning analyticsKhan Academytechnology-enhanced learningvisualizations
DIE MARINA S.R.L.

DAS UNTERNEHMEN WURDE 1981 DURCH GESETZ VOM 31/03/1981 GEGRÜNDET UND NAHM SEINE TÄTIGKEIT 1997 AUF. SEIT 2003 ÜBT ER IN FORM EINER GESELLSCHAFT MIT BESCHRÄNKTER HAFTUNG DIE TÄTIGKEIT DER HOTELLEITUNG AUS. DAS GRUNDKAPITAL BETRÄGT EUR 80.000,00 BEWUSST UND GEZEICHNET; DIE AKTIONÄRE SIND BOLLANA CARLA FÜR 11 % UND DAS UNTERNEHMEN SUN SAIL S.S. MIT SITZ IN LUXEMBURG FÜR DIE RESTLICHEN 89 %. DAS UNTERNEHMEN FÜHRT SEINE TÄTIGKEIT IN DER GEMEINDE SESTRI LEVANTE IN DER PROVINZ GENUA DURCH UND VERWALTET EIN VIER-STERNE-HOTEL. DAS UNTERNEHMEN IST BESSER STRUKTURIERT UND MIT QUALIFIZIERTEN MITARBEITERN ORGANISIERT.
Unlocking intelligent workflow automation for the sme market through autto, an ai powered micro-automation saas platform

ABS Technology Limited (ABS) are an award-winning technology start-up based in London and set to revolutionise the way in which the professional service industry works according to Legal Geek who hailed them in the top 10 legal tech companies in 2016. Founder and CEO, Ian Gosling, has 20+ years of experience directing projects in Product Development, Business Model Development and Business Planning and is supported by a highly-qualified management team of legal, technical and business growth experts.
Professional services firms are still finding it easier, more cost effective and less risky to continue using expensive and overqualified people to complete routine work instead of automating their processes. This creates a barrier preventing these SME professional services companies from maximising productivity, ensuring quality and consistency and delivering the best value for money for their clients (B2B or B2C). 
ABS propose a solution that improves workflow efficiency through a Micro-Automation Platform (“AUTTO”). AUTTO is a disruptive software toolkit that addresses the true needs of SME legal and professional services by facilitating the automation of many short, low volume, repetitive processes that form 23% of legal work (40% across other professional services). Automation is a phenomenon that is driving business disruption globally, however is currently only accessible in the legal sector to large enterprises. AUTTO dramatically reduces the barriers for adoption of automation for SME law firms: It is significantly cheaper to licence, removes the cost of tech development and therefore makes automation possible at a viable cost in both time and money, with an expected payback period of less than one year for SMEs. Further, it will unlock increased productivity of skilled legal professionals who can turn their attention to higher-value activities instead, creating economic growth in the sector and ultimately making legal services more efficient and affordable.
Tourist brand and green biotechnology for the development of companies on a common resource: Citrus fruits

This project aims to increase the competitiveness of micro, small and medium companies in the cross-border area in connection with the agricultural, agri-food and “green” tourism sectors. Its common thread is the promotion of citrus, a quality and multifunctional product common to all regions. The rich biodiversity of the upper Mediterranean citrus fruits has resulted in a lively economic fabric that over time has built an "agricultural landscape" of great charm and strong tourist appeal. However, the size of the entrepreneurial fabric, consisting of micro, small and medium-sized companies, has limited market and tourism ambitions, currently only seasonal. The MARE DI AGRUMI project faces the challenge to co-create an original offer of innovative and universal citrus themed products and services that will stand out against other competing local strategies. There will be two ways to accomplish these objectives: 1) the green biotechnology supply chain will innovate citrus fruit waste production, transformation and management, while common aggregation and marketing strategies will promote the economic sustainability of agriculture, so important for commercial appeal; 2) new green tourism will expand the cross-border tourist offer and integrate it with the local socio-economic reality.  The innovative approach of this project focuses on the local economy and environmental issues such as transforming product waste into resources and activates the dialogue between public bodies, scientists, businesses and ordinary people for the creation of a new tourism brand through the Citizen Science approach and the creation of cross-border living labs.
OBSERVATORY OF DANGEROUS GOODS

The maritime transport sector is relevant for socio-economic development in both France and Italy. The transport of dangerous goods makes up a substantial part of this sector. The transport of dangerous goods makes up a substantial part of this sector. The marine area under investigation is particularly sensitive and rich in biodiversity, including the Cetacean Sanctuary, which extends over approximately 87 thousand square kilometres between the coasts of France, Liguria, Tuscany and Sardinia. Therefore, it is necessary to address the issue of maritime safety and the transport of Dangerous Goods (DGs) with a shared Italian-French approach and promote the adoption of joint control and monitoring systems improving on the current navigation surveillance systems used by the individual countries at their ports and with the competent authorities. The main objectives of the project are the following: 1) Designing and implementing a joint Italo-French information system/monitoring centre of maritime flows of dangerous goods and increased navigation safety; 2) Defining MoUs between cross-border institutional bodies and private/public parties to harmonise the functional and organisational procedures for monitoring the maritime traffic of dangerous goods; 3) Defining joint risk assessment standards; 4) Library of emergency management models for accidents at sea linked to DG transport and accident risk maps. Regions, public authorities and private parties who handle DGs will share and coordinate through the Monitoring Centre.
A Highly Sensitive Luminescent Dye@MOF Composite for Probing Different Volatile Organic Compounds

The probing of volatile organic compounds (VOCs) is critical and challenging in biotechnology and environmental monitoring. Incorporation of luminescent moieties into metal-organic frameworks (MOFs) has produced many unique luminescent sensors for probing different VOCs. The emissions of most MOF sensors are based mainly on the single transitions of luminescent moieties, so the luminescence readouts are only predominant for some special VOCs. We use a natural amino acid derivative as the luminescent moiety to result in a lamellar coordination polymer, and further embed luminescent dye molecules in the crystal matrix to result in a luminescent dye@MOF sensor. The composite sensor exhibits excellent sensitivity for decoding different VOCs with clearly differentiable fluorescence emission by tuning the energy transfer efficiency from the organic ligand to the dye moieties. The composite luminescent sensor is self-calibrated, and much more stable and instantaneous than other more widely explored luminescent sensors.
Biological, Chemical, and Omics Research ofTaxusMedicinal Resources

Taxus is a botanical source for the anticancer drug taxol (paclitaxel), first reported in 1971 as a result of bioassay guided fractionation of active extracts from stem bark samples of T. brevifolia. This led to additional discoveries of pharmacologically active taxoids in other Taxus species and to investigations on their biosynthetic precursors, analogues, and derivatives. In continuation with our studies on Taxus biochemistry, we review the genomics, transcriptomics, proteomics, metabolomics, and bioinformatics of Taxus and their endophytic fungi. The bibliometric method is used to quantify and characterize the global scientific effort in the omics technologies being applied. We conclude that systems biology and omics technologies will play an increasingly important role in future medical research involving bioactive compounds of Taxus and other natural products. Drug Dev Res 73 : 477-486, 2012. (C) 2012 Wiley Periodicals, Inc.