SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Human Corneal MicroRNA Expression Profile in Fungal Keratitis

MicroRNAs (miRNAs) are small, stable, noncoding RNA molecules with regulatory function and marked tissue specificity that posttranscriptionally regulate gene expression. However, their role in fungal keratitis remains unknown. The purpose of this study was to identify the miRNA profile and its regulatory role in fungal keratitis.Normal donor (n = 3) and fungal keratitis (n = 5) corneas were pooled separately, and small RNA deep sequencing was performed using a sequencing platform. A bioinformatics approach was applied to identify differentially-expressed miRNAs and their targets, and select miRNAs were validated by real-time quantitative PCR (qPCR). The regulatory functions of miRNAs were predicted by combining miRNA target genes and pathway analysis. The mRNA expression levels of select target genes were further analyzed by qPCR.By deep sequencing, 75 miRNAs were identified as differentially expressed with fold change greater than 2 and probability score greater than 0.9 in fungal keratitis corneas. The highly dysregulated miRNAs (miR-511-5p, miR-142-3p, miR-155-5p, and miR-451a) may regulate wound healing as they were predicted to specifically target wound inflammatory genes. Moreover, the increased expression of miR-451a in keratitis correlated with reduced expression of its target, macrophage migration inhibitory factor, suggesting possible regulatory functions.This is, to our knowledge, the first report on comprehensive human corneal miRNA expression profile in fungal keratitis. Several miRNAs with high expression in fungal keratitis point toward their potential role in regulation of pathogenesis. Further insights in understanding their role in corneal wound inflammation may help design new therapeutic strategies.
Proactive safety systems and tools for a constantly upgrading road environment

Future transport and mobility will be disrupted by innovations in Connected Automated Vehicles (CAVs), in which safety will be of the highest priority. SAFE-UP aims to proactively address the upcoming safety challenges by developing innovative technologies, testing and assessment methods. SAFE-UP is based on 3 key pillars: i) future safety-critical scenarios, ii) new safety technologies, and iii) novel safety assessment methodologies. Future safety-critical scenarios will be designed and analysed in a highly automated and mixed traffic environment in a traffic simulation platform. Based on these scenarios, new safety technologies for active and passive systems will be developed, resulting in 4 Demos. The passive safety system of Demo 1 will include restraint and occupant monitoring technologies for new seating positions. Three active safety system prototypes (all on-vehicle, one of them also including on-user and infrastructure) will be developed. Demo 2 will enhance the interaction between vehicles and VRUs under bad weather conditions while Demo 3 will integrate advanced intervention functions to avoid critical events. Demo 4 will consist of a safety solution based on C-ITS to enable timely warning provisions. To prove the overall benefits, new safety assessment methodologies will be thoroughly designed. The SAFE-UP consortium is another major asset, consisting of key players in mobility across the entire value chain: advanced OEMs, leading suppliers & industry, and academia. The new technologies will reduce fatalities by covering pedestrians, cyclists and Powered Two Wheelers in urban areas through active safety systems and cars in non-urban through passive safety technologies, which will impact 64% of all road fatalities. SAFE-UP will also develop targeted education and training schemes for fostering the implementation of automated driving functions, while also focusing on raising awareness of future road safety challenges.
Neuromuscular Activity of Micrurus laticollaris (Squamata: Elapidae) Venom in Vitro

In this work, we have examined the neuromuscular activity of Micrurus laticollaris (Mexican coral snake) venom (MLV) in vertebrate isolated nerve-muscle preparations. In chick biventer cervicis preparations, the MLV induced an irreversible concentration- and time-dependent (1-30 µg/mL) neuromuscular blockade, with 50% blockade occurring between 8 and 30 min. Muscle contractures evoked by exogenous acetylcholine were completely abolished by MLV, whereas those of KCl were also significantly altered (86% ± 11%, 53% ± 11%, 89% ± 5% and 89% ± 7% for one, three, 10 and 30 µg of venom/mL, respectively; n = 4; p < 0.05). In mouse phrenic nerve-diaphragm preparations, MLV (1-10 µg/mL) promoted a slight increase in the amplitude of twitch-tension (3 µg/mL), followed by neuromuscular blockade (n = 4); the highest concentration caused complete inhibition of the twitches (time for 50% blockade = 26 ± 3 min), without exhibiting a previous neuromuscular facilitation. The venom (3 µg/mL) induced a biphasic modulation in the frequency of miniature end-plate potentials (MEPPs)/min, causing a significant increase after 15 min, followed by a decrease after 60 min (from 17 ± 1.4 (basal) to 28 ± 2.5 (t15) and 12 ± 2 (t60)). The membrane resting potential of mouse diaphragm preparations pre-exposed or not to d-tubocurarine (5 µg/mL) was also significantly less negative with MLV (10 µg/mL). Together, these results indicate that M. laticollaris venom induces neuromuscular blockade by a combination of pre- and post-synaptic activities.
Innovactis 2019

The objective of this project is to provide innovation support services in 2019 to SMEs in the regions covered by the consortium members. These innovation support services will be differentiated for two groups of SMEs:
a) SMEs that have been selected as beneficiaries of the SME Instrument (Phase 1 or Phase 2), FTI or FET-Open funding schemes. For these companies, the consortium members will offer Key Account Management (KAM) services, which are accompanying services for the SMEs to identify weaknesses in their innovation capacities and suitable external coaches throughout their participation in the SME instrument.
b) SMEs that have high potential for growth and internationalisation but that need to improve their innovation management capacities. These companies will receive direct assessment services from the consortium members in order to detect barriers and develop and implement an action plan in order to enhance such capacities and overcome the detected barriers.
Etanercept Administration to Neonatal SH3BP2 Knock-In Cherubism Mice Prevents TNF-α-Induced Inflammation and Bone Loss

Cherubism is a genetic disorder of the craniofacial skeleton caused by gain-of-function mutations in the signaling adaptor protein, SH3-domain binding protein 2 (SH3BP2). In a knock-in mouse model for cherubism, we previously demonstrated that homozygous mutant mice develop T/B cell-independent systemic macrophage inflammation leading to bone erosion and joint destruction. Homozygous mice develop multiostotic bone lesions whereas cherubism lesions in humans are limited to jawbones. We identified a critical role of tumor necrosis factor α (TNF-α) in the development of autoinflammation by creating homozygous TNF-α-deficient cherubism mutants, in which systemic inflammation and bone destruction were rescued. In this study, we examined whether postnatal administration of an anti-TNF-α antagonist can prevent or ameliorate the disease progression in cherubism mice. Neonatal homozygous mutants, in which active inflammation has not yet developed, were treated with a high dose of etanercept (25 mg/kg, twice/week) for 7 weeks. Etanercept-treated neonatal mice showed strong rescue of facial swelling and bone loss in jaws and calvariae. Destruction of joints was fully rescued in the high-dose group. Moreover, the high-dose treatment group showed a significant decrease in lung and liver inflammatory lesions. However, inflammation and bone loss, which were successfully treated by etanercept administration, recurred after etanercept discontinuation. No significant effect was observed in low-dose-treated (0.5 mg/kg, twice/week) and vehicle-treated groups. In contrast, when 10-week-old cherubism mice with fully active inflammation were treated with etanercept for 7 weeks, even the high-dose administration did not decrease bone loss or lung or liver inflammation. Taken together, the results suggest that anti-TNF-α therapy may be effective in young cherubism patients, if treated before the inflammatory phase or bone resorption occurs. Therefore, early genetic diagnosis and early treatment with anti-TNF-α antagonists may be able to prevent or ameliorate cherubism, especially in patients with a mutation in SH3BP2.
ReputationBox: A system to analyse importance of emails and reputation of email senders

e-Mail is one of the primary mediums of electronic communication used today. The number of email accounts are expected to go over 4.3 billion accounts by the year 2016 according to the latest email statistic reports. Users receive a bulk of emails on a daily basis and consequently they tend to overlook their inboxes and miss important emails from important people. This email management issue imposes an adverse effect on the productivity of email communication. Although many email clients today are equipped with tools to filter emails based on keywords, email addresses; most of these filters are static and are not updated automatically. The productivity of email communication will drastically improve if emails can be automatically evaluated for their goodness, so that users can promptly identify important and interesting emails before reading them and proceed with suitable actions on a timely manner.
Inside speakers' corner. late medieval italian anchoresses in european context.

Voluntary reclusion was an ancient form of penitential religious life based on withdrawing into a tight space, either temporarily or forever. The particular phenomenon of urban reclusion which flourished in the 13th and 14th centuries was a mainly female activity, need not be tied to a religious order, and seems to have been linked to the expansion of cities across Europe. It is an important indicator of female levels of religious participation and of their social role since these women often acted as consultants and advisors to the wider community. This research project will thus improve our understanding of a
phenomenon that characterized all of Latin Europe, as of the condition of medieval woman, while also reshaping our image of the medieval city, to one scattered with cells. There is, currently, a great disparity in historiographical terms between Italy and the rest of the continent on this subject. Whereas some parts of Europe and of northern Italy are relatively well researched, others are devoid of studies. The aim of this project is thus to verify whether – and if so, how and why – there was an Italian model of reclusion with characteristics different to those beyond the Alps; how recluses related to the urban communities from which they withdrew and the extent to which this phenomenon was a way for medieval women to break the silence imposed by St Paul (""Women are to be silent in the churches. They are not permitted to speak"",1 Corinthians 14:34); to exercise from and thanks to the cell a sort of power on the civil and ecclesiastical society; to break out of conventional, restricted roles of mother or wife or nun imposed by the medieval society, or more often a dignified way of life for poor single women, for whom the lack of a dowry barred entry to a nunnery or marriage. The first step will thus be the construction of a prosopographical database of Italian anchoresses mapping the phenomenon, followed by a comparative study of Italy in European context
MULTI-PORT LED-BASED LIGHTING COMMUNICATIONS GATEWAY

A multi-port communications gateway for one or more LED based illumination devices includes a lighting communications interface that is configured to be coupled to the LED based illumination device(s). The lighting communications interface transmits both data signals and power signals. A lighting control network interface is configured to be coupled to a lighting control system, which generates control commands. A building management network interface is configured to be coupled to a building management system and is configured to receive and transmit information from sensors coupled to the LED based illumination device(s). Memory in the gateway stores information received from the LED based illumination device (s). A processor determines a summary status value associated with the LED based illumination device(s) based on information stored in memory. A real time clock determines a date and time that is periodically transmitted to the LED based illumination device(s).
External thermostat fan controller

A programmable controller circuit that can be connected directly to the fan switch of any thermostat with a forced air heating and/or cooling system that includes a blower fan for circulating air throughout the home. The controller can be installed with minimal modifications to the existing wiring. The present invention increases the efficiency of the cooling system by evaporating condensate and extracting residual coolness from the thermal mass of the evaporator coils. The present invention can be programmed with a single button. A method of adapting additional fan run time based on compressor run time.
Neocortical circuits underlying visually-guided behaviors in mice.

Many of our most common behaviors, such as reaching out to grasp an object or turning towards something of interest, require that we transform visual information into a representation that guides action. In humans and other mammals, key steps in this transformation take place in the cerebral cortex, by the cooperative action of multiple cortical areas. How does this cooperation occur? The classical hypothesis holds that cortical areas act in series, each performing a unique step of the transformation and passing on the result, like workers on an assembly line. In an alternative hypothesis the transformation occurs in a distributed fashion, with multiple cortical areas participating jointly in each step. In this hypothesis each area may function more like people lifting a table together by its sides. 

To test these competing hypotheses, I propose to record simultaneously from populations of neurons in six key cortical areas in mice performing a visual discrimination task. The task is designed to separate and quantify the contributions of each area to visual perception, decision-making, and action. The results will distinguish between the two competing hypotheses and reveal the distinct – or shared – roles of each cortical area. Then, I will put these conclusions to the test by silencing neurons in each of three areas and comparing the effects of inactivation on behavior. Together these experiments will reveal the fundamental mechanisms of how cortical circuits cooperate to produce visually-guided behaviors.

I will perform these experiments in the Cortical Processing Laboratory at University College London, led by Kenneth Harris and Matteo Carandini.
Common framework for a european life cycle based asset management approach for transport infrastructure networks

Achieving a well integrated, optimal performing transport infrastructure network in Europe is a key element in the White Paper on Transport’s overall ambition for a single European Transport Area in 2050. As such it complements and supports the pillars on efficient and sustainable transport means and operations. 
The required integration and enhancement of the European transport infrastructure networks needs a shift towards next levels of governance capabilities that can adequately address the key societal challenges. In the framework of this CSA on a life cycle based asset management approach for transport infrastructure networks, these challenges are related to: 
An unprecedented call for network capacity and performance
An unprecedented call for transparent, coherent and consistent decision making on cost-performance
The (mostly public) financing of the transport infrastructure system has met with concrete fiscal limits. Already in many countries in the EU, this has led to a backlog in maintenance and replacement. Unless decisive actions are taken on network construction, maintenance and operations, this trend will result in mounting congestion losses in the economic powerhouses on the short term and to prohibitive  obstructions in transport flows across the European transport network on the medium term. This calls for cross asset, cross modal and cross border decision making by the appropriate authorities, implying their close coordination and collaboration. The precondition for this is transparency to each other as well as to policy and society. This requires them to share a common vision and objectives, in a common language and from a common information base.
The governance challenge is to provide the key stakeholders in the infrastructure governance with appropriate data, methods and tools in order to enable their decision making on cost-performance to be transparent, coherent and consistent across the assets, across the modes, and across the borders.
Evaluation of Sustainability of Smallholder Dairy Production Systems in the Highlands of Mexico During the Rainy Season

A sustainability evaluation was undertaken with 22 smallholder dairy farms in the highlands of Mexico; following the IDEA method in the agroecological, socioterritorial, and economic scales (all scales are out of 100). Sustainability was highest for the agroecological scale (59/100), intermediate for the socioterritorial scale (53/100), and lowest on the economic scale (43/100). The sustainability of a farm is the lowest score of the three scales. In most farms, the lowest was the economic scale. A cluster analysis led to the identification of five distinct groups: Cluster 1 defined two farms not related to others, cluster 2 farms (4) were those with high agroecological scores, cluster 3 farms (8) were most representative of the area, cluster 4 included two farms with low socioterritorial and economic sustainability scores, and cluster 5 was made up of the remaining six farms with the highest economic sustainability score, but limited by the agroecological and socioterritorial scales. In all farms, there ...
Fast

As part of this project, Data Artisans aims to further develop the software Flink, which can be used to process very large data en (big data) in a short time. In M ittelpunkt there is a better scalability, easier configuration and programmability of Flink compared to competitors (e.g. Hadoop).
NASAL DILATOR

A nasal dilator is provided that can be used primarily for exercise and secondarily rest/sleep. It may be designed as a resilient bridge between two arms that enter the nostril then expand the nostril outward and upward. In one embodiment the dilator is flexible and the feet are brought together when inserted and when released they return outward and press against the nasal wall thus opening the nostrils. The feet may have an offset from the arm to deeper engage the nostril which helps to prevent the dilator from slipping off. Also the inside face of the feet and arm that run parallel to the septum wall may be generally flat to prevent irritation to the septum wall if pressed up against the septum wall. The easy to use and reusable nasal dilator can be used by athletes to better performance through improved utilization and flow of air.
Transformations of asymptotic gravitational-wave data

Gravitational-wave data is gauge dependent. While we can restrict the class of gauges in which such data may be expressed, there will still be an infinite-dimensional group of transformations allowed while remaining in this class, and almost as many different---though physically equivalent---waveforms as there are transformations. This paper presents a method for calculating the effects of the most important transformation group, the Bondi-Metzner-Sachs (BMS) group, consisting of rotations, boosts, and supertranslations (which include time and space translations as special cases). To a reasonable approximation, these transformations result in simple coupling between the modes in a spin-weighted spherical-harmonic decomposition of the waveform. It is shown that waveforms from simulated compact binaries in the publicly available SXS waveform catalog contain unmodeled effects due to displacement and drift of the center of mass, accounting for mode-mixing at typical levels of 1%. However, these effects can be mitigated by measuring the average motion of the system's center of mass for a portion of the inspiral, and applying the opposite transformation to the waveform data. More generally, controlling the BMS transformations will be necessary to eliminate the gauge ambiguity inherent in gravitational-wave data for both numerical and analytical waveforms. Open-source code implementing BMS transformations of waveforms is included along with this paper in the supplemental materials.
Developing a chlamydia trachomatis vaccine

The TRACVAC Consortium will eliminate the global problem of blinding trachoma through the development of a vaccine. Our strategy of the project will eliminate two important bottlenecks for the development of a trachoma vaccine 1) The lack of neutralizing antibody responses to vaccine preparations based on MOMP 2) The challenge of inducing vaccine promoted sustained local ocular IgA.

TRACVAC has two main objectives. The first main objective is to generate a vaccine that protect against the bacterial strains causing ocular Chlamydia trachomatis infections. To accomplish this we first select naturally protected individuals from high endemic regions and identify all neutralizing epitopes from the major outer membrane antigen (MOMP) of Chlamydia trachomatis through the unique combination of the B cell cloning and high density array technology. The epitopes will be produced as vaccines through the use of the immuno-repeat technology that is known to increase the quality and quantity of the vaccine promoted response. The second main objective is to develop an immunization protocol for optimal ocular mucosal immunity. To do this we will establish an ocular non-human primate (NHP) challenge model and use this to test different prime boost vaccination strategies for ocular responses and protection against challenge. We will subsequently test the best strategy in a clinical phase I evaluation of a trachoma vaccine based on a immuno-repeat construct targeting serovar B. This will provide early human proof of concept both for the immuno-repeat technology and the prime boost strategy for ocular IgA. In summary, TRACVAC will deliver a final vaccine candidate targeting the main ocular serovars and a vaccine protocol ready to enter a clinical phase I trial.

TRACVAC is highly relevant for the topic (Vaccine development for malaria and/or neglected infectious diseases), as the aim is to accelerate vaccine development against the neglected infectious disease Trachoma.
DYNAMIC FLOW REDISTRIBUTION FOR HEAD LINE BLOCKING AVOIDANCE

An apparatus and related methods are provided to greatly reduce the negative impact of head of line (HOL) blocking. At a device (e.g., switch, router, etc.) configured to forward packets in a network, new packets that are to be forwarded from the device to other devices in the network are stored in a memory of the device. Entries are added to a queue link list for the at least one queue as new packets are added to the at least one queue. A detection is made when the at least one queue exceeds a threshold indicative of head of line blocking. For new packets that are to be added to the at least one queue, entries are added to a sub-queue link list for the plurality of sub-queues such that packets are assigned to different ones of a plurality of sub-queues when the at least one queue exceeds the threshold. Packets are output from the memory for the plurality of sub-queues according to the sub-queue link list.