SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Pushing the frontiers of biological imaging with genetically encoded fluorescence switches

Biological imaging is essential for revealing the inner workings of living systems. Among the numerous imaging modalities, light microscopy has revolutionized biological research. In addition to advances in optics and detectors, imaging has benefited from the development of molecular tools to observe biomolecules in action. Although the last decade’s breakthroughs in imaging have led to new discoveries in biology, there are still extraordinary opportunities for basic and clinical research in further advancing imaging capabilities. This project proposes to develop new classes of probes to advance biological imaging and allow the study of biological processes in all their complexity. First, I propose to push the boundaries of multiplexing and super-resolution imaging in living cells developing a new class of fluorogenic probes that act as genetically encoded fluorescence on/off switches. Highly multiplexed images will be built up over sequential activation of orthogonal fluorescence on/off switches, while continuous switching will allow implementing innovative dynamic super-resolution techniques in living cells. Then, I will develop dynamic fluorescence on/off switches enabling to reveal the dynamics of intracellular processes, focusing in particular on the visualization of interaction dynamics in real-time, and the dynamic detection of endogenous molecules (e.g. proteins, nucleic acids) in living cells. The final part will be dedicated to the development of probes acting as molecular integrator switches to identify active cell circuits in whole tissues or organisms through permanent labeling of transiently activated cells. Overall, this project will enable to push back the frontiers of biological imaging providing innovative tools to interrogate quantitatively and comprehensively living systems at the molecular, cellular and network levels.
Integrated and Interoperable Maritime Transit Management System

ICT technologies (including interoperable web-platforms and emerging technologies such as RFIDs) have proven of great assistance to tackle MED/EU port challenges regarding logistics and communication systems. Their customized use in different ports has limited their effect. Hence, it is essential to develop a communication framework between ports, administrations, logistic activities areas, relevant operators and commercial stakeholders. Towards this direction, INTE-TRANSIT aims in a better organization of MED ports and their logistic activities areas and establish a cooperation framework between relevant stakeholders in MED countries for best practice exchange, cooperation and personnel training. More specifically, INTE-TRANSIT will be focusing on the following: - Strengthen communication links between i) ports and relevant authorities across the MED Basin, ii) all relevant actors in the maritime transfers and iii) ports and their logistic activities areas, through the use of modern ICT technologies that will be used to enhance information management systems - Define an integrated management model involving public and private organizations (in ports and their logistic activities areas) and devise a common and harmonized MED processes map and indicators. This will lead to more efficient ports interoperability and a relevant improvement of the flow of goods, cargo traceability, visibility and transparency - Provide a training framework for ports and logistic areas personnel (administrative/managerial and labour workers). Training sessions will be provided towards the Ports, Port Authorities, Logistic Activities Areas Managers and Logistics partners, focusing on logistic/security frameworks, transportation tracking mechanisms, ports' telematics infrastructures as well as modern ICT technologies towards improved communications/cooperations - Execute 5 pilot projects to demonstrate improvement of logistic systems and port operations using the proposed new INTE-TRANSIT technologies. Two different sets of pilots will be executed to the involved ports: 1. Application of ICT technologies on container/cargo tracking/monitoring 2. Electronic tool/platform to implement the management model designed including the scoreboard associated - Develop/execute a best practice exchange framework for exchange of experience within the project as a sustainable means of communication beyond the project. Exchange visits will be focusing on knowledge gaining and awareness development on port modules (logistic organization, enhanced goods traceability, improved quality assurance) - Develop information awareness activities regarding dissemination towards results spreading to local and regional authorities and related target groups including project website, leaflets and poster, logo and the organization of 2 workshops.
Set plan/enve conference 2019

The 12th SET Plan Conference will be held during 12 - 14 June 2019, at the Politehnica University of Bucharest – Romania, under the auspices of the Romanian Presidency of the Council of the EU and will be conjoined with the external ENVE (Environment, Climate change and Energy) Commission and Conference within the European Committee of the Regions. ENVE is the Committee of the Regions’ Commission where more than 120 EU local and regional leaders are working for environment, climate change, energy and space policies.

The main organizer of the Conference is the Romanian Municipalities Association (AMR), being the first time in the SET-Plan history, when an association of local authorities will organize this conference. The organisation of the conference will be performed in close cooperation with the European Commission DG Energy, DG Research and Innovation and DG Communications Networks, Content and Technology, European Committee of the Regions, Ministry of Energy of Romania and the Ministry of Foreign and European Affairs of the Romania; the Global Covenant of Mayors; the Permanent Representation of Romania to the EU and Cityhall of the District 3 of Bucharest.

The main objective of the 12th year anniversary SET Plan conference is to perform an exchange of numerous innovative ideas and good practices with a clear involvement of local and regional leaders from the European Union in areas as: Integrated energy systems; Energy poverty and management of the energy transition in vulnerable regions; Improving performance and reducing cost of renewable energy; Energy Efficiency in Buildings; Energy Efficiency in Industry; Smart Cities; e-Mobility; Carbon Capture Utilisation and Storage; Digitalization and ICT in energy; Blue energy. Since this exchange should be inclusive, pragmatic and forward looking, we intend to involve a large number of EU, national, local and regional public and private stakeholders, academia, as well as a consistent number of political leaders.
A compact multichannel data acquisition and processing system for IoT applications

With the advent of Internet of Things (IoT), there is wide application and necessity for different kinds of data monitoring, be it in medical field, industrial field or research field. Hence there is a lot of data to be handled which is heterogeneous in nature. Combining data acquisition and data processing into a single system is a more efficient way of handling data. Spectrum estimation is one key method of processing. The novel aspect of the design described here is to implement a multichannel data acquisition system with embedded spectrum estimation at a reduced size, cost and power consumption. The method of implementing the proposed design is via Smart Fusion system on-chip device which combines circuits in analog and digital domains and allows the integration of a microcontroller and field programmable gate array (FPGA) fabric in a single chip.
STEEL FOR PRODUCING HIGH TENSILE STRUCTURAL COMPONENTS WITH EXCELLENT TOUGHNESS AT LOW TEMPERATURES AND USES OF SUCH A STEEL

The invention relates to a high tensile steel that has excellent ductile fracture values J integral even at low temperatures so that the danger of a fracture of the structural component produced from said steel is reduced to a minimum even under unfavorable and very hard working conditions. The inventive steel comprises (in % by weight) 0.08 - 0.25 % C, 0.10 - 0.30 % Si, 0.80 - 1.60 % Mn, = 0.020 % P, = 0.015 % S, the sum of P and S content being = 0.030 %, 0.40 - 0.80 % Cr, 0.30 - 0.50 % Mo, 0.70 - 1.20 % Ni, 0.020 - 0.060 % Al, 0.007 - 0.018 % N, = 0.15 % V, = 0.07 % Nb, the sum of V and Nb content being = 0.020 %, and the remainder iron and unavoidable impurities. The inventive steel is especially suitable for producing high tensile chains.
Resource bounded graph query answering

When we search for a product, can we find, using a single query, top choices ranked by Google and at the same time, recommended by our friends connected on Facebook? Is such a query tractable on the social graph of Facebook, which has over 1.31 billion nodes and 170 billion links? Is it feasible to evaluate such a query if we have bounded resources such as time and computing facilities? These questions are challenging: they demand a departure from the traditional query evaluation paradigm and from the classical computational complexity theory, and call for new resource-constrained methodologies to query big graphs.

This project aims to tackle precisely these challenges, from fundamental problems to practical techniques, using radically new approaches.  We will develop a graph pattern query language that allows us to, e.g., unify Web search (via keywords) and social search (via graph patterns), and express graph pattern association rules for social media marketing. We will revise the conventional complexity theory to characterize the tractability of queries on big data, and formalize parallel scalability with the increase of processors. We will also develop algorithmic foundations and resource-constrained techniques for querying big graphs, by ``making big data small''. When exact answers are beyond reach in big graphs, we will  develop data-driven and query-driven approximation schemes to strike a balance between the accuracy and cost. As a proof of the theory, we will develop GRACE, a system to answer graph pattern queries on big GRAphs within bounded resourCEs, based on the techniques developed. We envisage that the project will deliver methodological foundations and practical techniques for querying big graphs in general, and for improving search engines and social media marketing in particular. A breakthrough in this subject will advance several fields, including databases, theory of computation, parallel computation and social data analysis.
SOSTEGNO ALLA LIQUIDITA' PER MICROIMPRESE COLPITE DALL'EMERGENZA COVID

SOSTEGNO ALLA LIQUIDITA' DELLE MICRO E PICCOLE IMPRESE DEI SETTORI COMMERCIO AL DETTAGLIO, SOMMINISTRAZIONE E SERVIZI ALLA PERSONA, LA CUI ATTIVITA' SIA STATA SOSPESA PER EFFETTO DEL DPCM 11 MARZO 2020
Autophagy is involved in the early step of Japanese encephalitis virus infection

Japanese encephalitis virus (JEV), an enveloped Flavivirus with a positive-sense RNA genome, causes acute encephalitis with high mortality in humans. We used a virulent (RP-9) and an attenuated (RP-2ms) JEV strain to assess the role of autophagy in JEV infection. By monitoring the levels of lipidated LC3, we found that autophagy was induced in human NT-2 cells infected with RP-2ms, especially at the late stage, and to a lesser extent with RP-9. The induction of autophagy by rapamycin increased viral production, whereas the inhibition of autophagy by 3-methyladenine reduced viral yields for both RP-9 and RP-2ms. The viral replication of RP-9 and RP-2ms was also reduced in cells with downregulated ATG5 or Beclin 1 expression, suggesting a proviral role of autophagy in JEV replication. To determine the step of JEV life cycle affected by autophagy, we used an mCherry-LC3 fusion protein as the autophagosome marker. Little of no colocalization of LC3 puncta with dsRNA was noted, whereas the input JEV particles were targeted to autophagosomes stained positive for early endosome marker. Overall, we show for the first time that the cellular autophagy process is involved in JEV infection and the inoculated viral particles traffic to autophagosomes for subsequent steps of viral infection.
Ejection accretion structures in ysos (easy)

For a number of reasons, in particular their proximity and the abundant range of diagnostics to determine their characteristics, outflows from young stellar objects (YSOs) offer us the best opportunity of discovering how astrophysical jets are generated and the nature of the link between outflows and their accretion disks. Models predict that the jet is initially launched from within 0.1 to a few au of the star and focused on scales at most ten times larger. Thus, even for the nearest star formation region, we need high spatial resolution to image the “central engine” and test current models.  
With these ideas in mind, and the availability of a whole new set of observational and computational resources, it is proposed to investigate the origin of YSO jets, and the jet/accretion zone link, using a number of highly novel approaches to test magneto-hydrodynamic (MHD) models including: 
(a) Near-infrared interferometry to determine the spatial distribution and kinematics of the outflow as it is launched as a way of discriminating between competing models,  
(b) A multi-epoch study of the strength and configuration of the magnetic field of the parent star to see whether model values and geometries agree with observations and the nature of its variability, 
(c) Examining, through high spatial resolution radio observations, how the ionized component of these jets are collimated very close to the source and how shocks in the flow can give rise to low energy cosmic rays,
(d)  Use the James Webb Space Telescope (JWST) and, in particular, the Mid-Infrared Instrument (MIRI) and Near-Infrared Spectrograph (NIRSpec) to investigate with high spatial resolution atomic jets from protostars that are still acquiring most of their mass. In addition, we will study how accretion is affected by metallicity by studying young solar-like stars in the low metallicity Magellanic Clouds. 
In all cases the required observational campaigns have been approved.
SYSTEM FOR VIEWING AND INTERACTING WITH A VIRTUAL 3-D SCENE

A system is described for enabling one or more user devices to view and interact with a three-dimensional (3-D) scene. The system comprises a data server (12) having a processor executing a program to create a virtual 3-D scene, and a user device (10) communicating remotely with the data server by way of a wired or wireless network. The user device (10) runs a user interface program for transmitting commands to the data server to modify the virtual 3-D scene and for displaying on a user screen an image that includes image data received from the data server as an encoded stream. The data server (12) is operative additionally to transmit commands to the user device for the purpose of altering the user interface.
A “RELIGIÃO DIFUSA” DE ROBERTO CIPRIANI

O objetivo deste texto é apresentar suscintamente a noção de “religião difusa” proposta por Roberto Cipriani no seu livro La religione diffusa. Teoria e prassi, publicado em 1988. Primeiramente, apresentaremos as discussões sobre a “religião difusa” ocorridas em 1983, durante a Conferência Internacional de Sociologia, no Bedford College, em Londres. Em seguida, analisaremos os pontos chaves desse conceito, expressos em seu ensaio-fundador, publicado em 1988, uma ampliação da relação discutida em Londres. Finalmente, avançaremos algumas considerações para a análise da realidade sócio-religiosa italiana atual.
European research and innovation centre of excellence in china

Europe actively engages internationally to strengthen its leadership in the field of Science, Technology and Innovation (STI) in the global scene and improve synergies between Member States. Europe aims to foster international cooperation and strengthen its STI presence in China due to its growing importance and STI opportunities for European actors. 
ERICENA (European Research Innovation Centre of Excellence in China), a 48 month initiative implemented by 8 European and 5 Chinese partners, proposes to set up a Centre and its networks in China to promote European STI interests in China, creating synergies with existing STI structures. ERICENA will connect and support European researchers, entrepreneurs and other STI stakeholders, while providing and facilitating provision of STI services (e.g. networking, advice and support, training, among others) to private and public clients. 
The Centre will be implemented along 4 stages (initial set-up, pilot, full operational and self-sustainable stages), in which all mechanisms will be structured and established to ensure the Centre’s long-term sustainable operation in China. The Centre will be established through the implementation of 6 strategic WPs, which are structured along 4 key pillars – strategy, operational, financial and implementation – as well as two cross-cutting supporting WPs. 
ERICENA will effectively contribute to improve cooperation between European STI organisations and researchers and their Chinese counterparts, strengthen the presence of European STI excellence in the Chinese market, maximize the impact of European STI actors in China, improve the framework conditions for EU-China cooperation, and expand the impact of results from existing European STI projects and initiatives in China. This vision will be closely supported and empowered through the wide involvement of stakeholders, including the consortium and more than 100 STI stakeholders in the EU and China involved as Associated Partners.
DOTT. ING. GIULIANO BOERO

THE PROFESSIONAL FIRM DEALS WITH THE DESIGN AND MANAGEMENT OF WORKS OF MECHANICAL SYSTEMS, ADVICE ON FIRE PREVENTION AND SAFETY IN THE WORKPLACE. IT CONSISTS OF A FREELANCER AND VARIOUS EXTERNAL COLLABORATORS. THE DIGITISATION OF THE OFFICE STRUCTURE WOULD FAVOUR SMART WORKING WITH THE POSSIBILITY OF ACCESS TO THE OFFICE SERVER ALSO FROM THE HOME. THIS INNOVATION IS ALSO AN IMPLENTATION REGARDING ACCESS TO PRACTICES REMOTELY WHEN YOU GO TO THE CUSTOMER’S OFFICES, AS WELL AS APPROACHING FROM THE POINT OF VIEW OF THE WEB CUSTOMERS OUTSIDE THE GENOESE TERRITORY THESE NEW TECHNOLOGIES COULD ALSO BE USED FOR THE USE AND DELIVERY OF ONLINE COURSES
Transatlantic cowgirl mobilities and the western show

Cowboys are known all over the world. They embody fantasies of mobility and adventure in the North American West to people around the globe. And naturally, we imagine cowboys as white and male figures who roam the prairies. The innovative action TACOMO takes a new look at cowboydom: It shows how cowGIRLS produce and revise cowboy gender norms in transnational cultural mobilities. Travelling with Buffalo Bill’s Wild West Show to Germany and Austria at the turn of the 20th century, female performers presented show acts such as trick riding, roping, and sharpshooting. Their acts addressed narratives of the frontier, American womanhood, and the gender norms of their European audiences, both through their performance (dialogue, costume, behavior) and its reception (newspaper commentary, advertising). 
TACOMO’s objective is to show that the gendered myth of the Wild West was created transatlantically in North America and in Europe. It explores three research questions: first, how did women performers experiment on the cowboy figure at Wild West Shows? Second, how did US cowgirldom interact with continental imperial gender roles? And third, how does their legacy resonate with present-day popular Western cultures in the US, Canada, Austria, and Germany? 
The action completes the researcher’s previous findings about female cowboys. It theorizes their performance through cutting edge fields of inquiry from Popular and Visual Culture, Mobility Studies and Transnational North American Studies, and it closes a gap in scholarly research on the myth of the American West. TACOMO’s special relevance to the H2020 program includes, first, a strong gender aspect in the diachronic research topic and in the researcher’s and the host’s gender-critical perspectives on academia; second, an appeal to general interest through its popular culture focus; and third, an understanding of culture as essentially mobile and produced in the travelling of ideas, persons, and objects between cultures.
Distinctions and distinctiveness in the work of prison officers: Legitimacy and authority revisited

The purpose of this paper is to provide a framework for thinking about the work of prison officers. It is a well-known maxim that relationships are ‘at the heart’ of prison life (Home Office, 1984). In this paper, I develop and illustrate this proposition, arguing that the moral quality of prison life is enacted and embodied by the attitudes and conduct of prison officers. There are important distinctions to be made in their work: between ‘good’ and ‘right’ relationships; ‘tragic’ and ‘cynical’ perspectives; ‘reassurance’ and ‘relational’ safety; and ‘good’ and ‘bad’ confidence. These distinctions are largely unseen but are decisive in shaping the prison’s moral and social climate. The best prison officer work can be described using these kinds of distinctions.
NEW PYRIDINE DERIVATIVES AS LEUKCOTRIENE B4 ANTAGONISTS

The invention pertains to new pyridine derivatives of formula (I) where . . . denotes a single bond or a double bond, m, n, p and r in each case stands for a number from 0 to 5, q is 1 or 2, U denotes a single bond or the grouping -CH2-CH2-, -CHOH-, -CO- -CH=CH-, -C=C-, -CO-CO- or -CHOH-CHOH-, V stands for a single bond, phenyl residue or pyridyle residue, W is a hydrogen atom, a halogen atom, an alkyl group with up to four carbon atoms, a trifluoromethyl group, an alkylsulfonylamino group, a trifluoromethylsulfonylamino group, an arylsulfonylaminocarbonyl group, a free, esterified or amidated carboxyl group, or a hydroxy group, X denotes a free, esterified or amidated carboxyl group, Y is an oxygen atom or a methylene group, and Z is a single bond if q is 2 or otherwise an alkyl group or alkylene group with at most 8 carbon atoms or a phenyl, phenoxy or styryl residue substituted by alkyl groups with at most 4 carbon atoms, alkoxy groups with at most 4 carbon atoms, 1-oxoalkyl groups with at most 4 carbon atoms, halogen atoms and/or trifluoromethyl groups. The invention also concerns salts of these derivatives with bases which are generally recognized as physiologically safe.