SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Cadmium and Lead Accumulation in Three Endogeic Earthworm Species

The objective of this study was to assess the capability of earthworms from the same ecological group as heavy metal bioindicators. Three earthworm species from the endogeic group were studied: Aporrectodea caliginosa (Savigny, 1826), Perelia kaznakovi (Michaelsen, 1910) and Octolasion lacteum (Örley, 1885). Their accumulation of the heavy metals lead (Pb) and cadmium (Cd) were studied from three stations in Tehran province, Iran. O. lacteum was used to compare metal accumulations in two sites located next to a highway. A. caliginosa and P. kaznakovi were used at a third site located near the edge of a sewage system to compare metal accumulations between the two endogeic species in this area. At both locations, the concentrations of Cd and Pb in earthworms were higher than in the surrounding soil. The results of the study revealed that P. kaznakovi and A. caliginosa were better bioindicators for Pb, but O. lacteum was a better bioindicator for Cd. These earthworms can therefore be used as Cd and Pb bioindicators in environmental assessment.
l-DOPA-induced behavioral sensitization of motor activity in the MPTP-treated common marmoset as a Parkinson's disease model

l -DOPA is the gold standard for treatment of Parkinson's disease (PD). However, the drug produces some serious side effects, including dyskinesia, which is characterized by repetitive involuntary movements—including chorea. In the present preclinical study using a nonhuman primate model, dyskinesia caused by repeated l -DOPA administration was investigated in the context of behavioral sensitization by objectively quantifying motor activity in the common marmoset of PD model (the Parkinsonian marmoset). Twelve male Parkinsonian marmosets previously treated with MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) and six intact male marmosets were used. The motor activity of each marmoset was measured using infrared sensors attached to each individual living cage. Parkinsonian marmosets (n = 6) exhibited behavioral sensitization (enhanced motor activity) in 10 weeks upon oral administration of l -DOPA (10 mg/kg per day on 3 days/week). These animals also exhibited dyskinesia characterized by repetitive rapid movements including chorea in 6–10 weeks. Neither behavioral sensitization nor dyskinesia was observed in Parkinsonian marmosets given vehicle and in intact marmosets given l -DOPA at the same dose (both n = 6 each). Behavioral sensitization was detected sensitively and objectively on motor activity only in Parkinsonian marmosets given repeated l -DOPA at a similar dose used in PD patients. The behavioral feature of the marmosets was dyskinesia similar to that of PD patients but appeared earlier than would be manifested in humans. In spite of statistically significant behavioral sensitization, some marmosets did not exhibit dyskinesia in the present limited l -DOPA administration period. Although both commonalities and differences may exist between behavioral sensitization and dyskinesia, behavioral sensitization is considered to be an objective, quantitative, sensitive and predictive measure of behavioral mechanism underlying dyskinesia in preclinical studies in evaluating compounds. • MPTP-treated common marmosets were used as a Parkinson's disease model. • Motor activity counts increased gradually by repeated administration of l -DOPA. • Behavioral sensitization of above measure accompanied with dyskinesia • Behavioral sensitization can be an objective and predictive measure of dyskinesia.
Blood Ethical good for Social capital and SafetY

Red Cross organisations, blood transfusion centres, promotion and recruitment organisations), in order to arrange an adequate policiy context and,at the same time, to support sanitary structures and NGOs to reach high performance levels with regard to the blood donation. IThe project will involve in all the partner countries collection of information regarding the blood donation issues, communication and training activities, analysis of methods and approaches in the promotion activities and management of Voluntary Non Remunerated Blood Donors (VNRBDs), as well as "health promotion” in general. The project will also produce printed and digital materials targeting the professionals that operate this field. In the transfusion system of some European countries different local policies assign different functions to the public health system and to the NGOs. These ones in Italy dedicate themselves mainly to the promotion of the culture of blood donation, finding donors and make them faithful, being on the lookout for the correct use of blood whereas the health service look after the transfusion services. In other countries every activity is carried out by the public system, in a lot of Soviet influenced countries all the services are delegated to Red Cross. The involvement of four countries in the BESSY project having different schemes in the management of the blood donation issues will permit to analyse various approaches and investigate on their efficiency and eventual improvement in order to obtain optimal model/s (social and economic) that allow to increase the values of blood social capital and contribute to the blood safety of the donors moving throughout Europe in particular in cross-border territories. Innovative aspects of the project are rappresented by: the experimentation of a Donor Card, the implementation of common promotional campaign, the costitution of the Know How and Expertise Center and Network and the creation of the Competence Network that will provide the recommendations and support to the national and regional governments in the field of blood donation issues. A very important aspect of the BESSY project is that it aims at investigating on the production of “social capital” - standing for a resource that characterizes the social relations network and defines the local communities life. Particular attention will be paid to the identification of best procedures in order to assure the maximum involvement in the initiative of different stakeholders and in the continuation of the foreseen activities even after the conclusion of the project assuring in this way the project sustainability. .
Vasorin: a newly identified regulator of ovarian folliculogenesis

Members of the TGF-β superfamily take part in the control of folliculogenesis. Vasorin (Vasn) is a newly identified negative regulator of TGF-β signaling whose possible involvement in ovarian physiology has never been studied. Here, we demonstrate that Vasn is expressed in the ovary by somatic cells of follicles, and that its expression is up-regulated by LH. We established a conditional knockout (cKO) mouse model in which Vasn is deleted specifically in granulosa cells of growing follicles from the secondary stage onwards. Using this model, we show that, upon hormonal stimulation, follicle ovulation size is almost 2-fold higher. This enhanced ovulatory response is associated with overactivation of the TGF-β signaling pathway and a lower number of atretic antral follicles. Of importance, we demonstrate that the number of primordial follicles is reduced in prepubertal cKO mouse ovaries, which suggests that the production of VASN by growing follicles protects the ovarian reserve. Finally, analysis of systemic KO mice revealed that the ovarian reserve is almost 2.5-fold higher, which implies that Vasn may also play a role in primordial follicle formation. Overall, our findings reveal that Vasn is a new regulator that exerts an effect on several key ovarian functions, including folliculogenesis, maintenance of the ovarian reserve, and ovulation.-Rimon-Dahari, N., Heinemann-Yerushalmi, L., Hadas, R., Kalich-Philosoph, L., Ketter, D., Nevo, N., Galiani, D., Dekel, N. Vasorin: a newly identified regulator of ovarian folliculogenesis.
WOVEN MULTI-LAYER FABRICS FOR USE WITH NON-BALLISTIC THREATS

A multi-layer woven fabric, including an upper woven layer having upper warp yarns and upper weft yarns that are interwoven together to form the upper woven layer. The cover factor of at least one of the layers is selected so as to inhibit penetration by non-ballistic threats
Inp membrane on silicon technology for a broad range of applications

Photonic technologies are key enablers for high-speed, on-demand communications, precision sensors, imaging and metrology. Industry roadmapping initiatives are now showing a clear and pressing need for miniaturising photonics solutions across market segments with sustained improvements in energy-efficiency, precision and performance. Photonic integration can meet these challenges, and has been convincingly demonstrated in fiber optic systems, but there is an absence of chip scale solutions for connectorless communications and sensor circuits requiring optical wireless connectivity. The necessary combination of high-performance optoelectronics, photonics integration, and chip-scale beam forming is not available to the industry.

IMOS – Indium Phosphide membrane on Silicon enables the combination of nanophotonics, photonic integration, lasers, amplifiers and the highest efficiency electro-optic processes. Integrated nanophotonics offers a route to exquisite optical beam control within the chip, and removes the need for fiber optic connectivity, micro-mechanical-assemblies and off-chip optics. The ERC project NoLimits has pioneered a nanophotonic platform which additionally integrates lasers, semiconductor optical amplifiers, high performance detectors and low-loss, fabrication-tolerant surface grating technologies. The IMOS4ALL program will implement the most comprehensive set of active and nanophotonic building blocks as created in the ERC project NoLimits and make them available within one wafer scale process and valid the platform with industry-inspired circuits. The free placement of standard high-performance building blocks enables the project to deliver an open-access platform where designers configure circuits to enable new and unanticipated circuits. The platform approach also enables the integration of a pipeline of future high-performance building blocks for future technology nodes.
The missing link: how do membrane lipids interplay with atg proteins to instruct plant autophagy

Autophagy is an intracellular catabolic process critical to eukaryotic life and indispensable for plant survival to drought, nutrient scarcity or pathogen attacks. Autophagy relies on the formation of specialized vesicles called autophagosomes (AP) which engulf and deliver cell components to the lytic vacuole. AP biogenesis is carried out by a group of dedicated proteins (named ATG) and hinges on intense remodelling events and on the remarkable capacity of an initial membrane, the phagophore, to assemble de novo, shape like a cup, expand while maintaining structure and function and re-shape to a complete vesicle. To date the molecular mechanisms underlying these events remain elusive. Research has focused on the role of autophagy proteins but, despite AP biogenesis being a membrane-based process, the fundamental contributions of lipids to AP membrane formation, identity and activities have been largely unexplored; in other words, when it comes to AP formation we are only looking at half of the picture.

I propose to address the fundamental question of how APs form and shape from a novel angle: by exploring how lipids’ nature, dynamics and lateral heterogeneity instruct the phagophore structure, its protein composition and its functions. The project builds on our recent results and expands on strategies that we have developed, integrating proteomic/bioinformatic approaches, lipidomics and high-resolution 3D imaging. We will tackle 3 complementary objectives: 1) Reveal the dynamic lipid signature of the phagophore, 2) Elucidate the implication of lipids nature and repartition in the phagophore ultrastructure, 3) Decrypt the molecular mechanisms by which lipids interplay with ATG proteins to control autophagy activity and plant physiology. Overall the project will articulate an integrated vision of the molecular processes controlling autophagy and provide fundamental knowledge in our understanding of plant adaptive programs.
Implementation of galvanic treatment of steel containers for increased corrosion resistance and hardness of coatings, taking into account environmental and energy aspects

As part of this project, the applicant intends to implement a new technology in the company that will enable the preparation of containers for logistics and internal transport with improved corrosion resistance and coating strength. The implementation of this project will enable the product to be included in the offer of a product characterised by greater resistance to rust and increased durability, which will ensure that the product will have an extended life span and thus will have a positive impact on the environment. This project contributes to meeting the objectives of Action 3.2, which consist of the development of innovation among Polish enterprises in the SME sector, as well as the implementation and commercialisation of new, technologically advanced products. Moreover, investment is in line with the implementation of horizontal policies of the European Union, and in particular the principle of sustainable development.
The role of intravesicular atp in excitatory and inhibitory synapses of the central nervous system

COST-ATP pretends to establish the role of intravesicular ATP in excitatory and inhibitory synapses of the central nervous system (CNS). Although, several laboratories have characterized the crucial interaction between ATP and catecholamines to permit its large accumulation in secretory vesicles of chromaffin cells, this crucial mechanism has not been studied in synaptic vesicles where high concentrations of neurotransmitters are needed for neuronal communication in the CNS. COST-ATP will combine the experience of the host laboratory in ATP as an accumulator of neurotransmitters in chromaffin cells and the TIRFM technology, and the ample experience of the researcher in cutting edge electrophysiological techniques in hippocampal neurons. The project will use electrophysiology, TIRFM, molecular biology and pharmacological tools to first discern the packagingbrole of vesicular ATP from its actions as neurotransmitter in central synapses using autaptic cultures of mouse hippocampal neurons. COST-ATP wants to explain why ATP is present inside of synaptic vesicles of almost all neurons. The main
advantage of our approach is that we can modify the vesicular ATP by acting on the specific vesicular nucleotide carrier (VNUT) without affecting its cellular functions as the molecular energy. The consideration of the ATP, by its colligative properties, as a regulator of the neurotransmission, opens a new door in the neuronal communication. Given that its accumulation is mediated by VNUT a regulation of its activity could constitute a new pharmacological target for the treatment of neurological, psychiatric and cardiovascular diseases without involving membrane receptors.
Timo Strauch, Der Codex des Antonio da Faenza: Die Traktatsammlung eines Künstlers im frühen 16. Jahrhundert, 2 vols (Petersberg: Michael Imhof Verlag, 2019), 664 pp. plus facsimile of 256 pp., ISBN 9783731904403, €159

Timo Strauch, Der Codex des Antonio da Faenza: Die Traktatsammlung eines Künstlers im frühen 16. Jahrhundert, 2 vols (Petersberg: Michael Imhof Verlag, 2019), 664 pp. plus facsimile of 256 pp., ISBN 9783731904403, €159 - Volume 65
WE-EF-207-03: Design and Optimization of a CBCT Head Scanner for Detection of Acute Intracranial Hemorrhage

Purpose: To design a dedicated x-ray cone-beam CT (CBCT) system suitable to deployment at the point-of-care and offering reliable detection of acute intracranial hemorrhage (ICH), traumatic brain injury (TBI), stroke, and other head and neck injuries. Methods: A comprehensive task-based image quality model was developed to guide system design and optimization of a prototype head scanner suitable to imaging of acute TBI and ICH. Previously reported models were expanded to include the effects of x-ray scatter correction necessary for detection of low contrast ICH and the contribution of bit depth (digitization noise) to imaging performance. Task-based detectablity index provided the objective function for optimization of system geometry, x-ray source, detector type, anti-scatter grid, and technique at 10–25 mGy dose. Optimal characteristics were experimentally validated using a custom head phantom with 50 HU contrast ICH inserts imaged on a CBCT imaging bench allowing variation of system geometry, focal spot size, detector, grid selection, and x-ray technique. Results: The model guided selection of system geometry with a nominal source-detector distance 1100 mm and optimal magnification of 1.50. Focal spot size ∼0.6 mm was sufficient for spatial resolution requirements in ICH detection. Imaging at 90 kVp yielded the best tradeoff between noise and contrast. The model provided quantitation of tradeoffs between flat-panel and CMOS detectors with respect to electronic noise, field of view, and readout speed required for imaging of ICH. An anti-scatter grid was shown to provide modest benefit in conjunction with post-acquisition scatter correction. Images of the head phantom demonstrate visualization of millimeter-scale simulated ICH. Conclusions: Performance consistent with acute TBI and ICH detection is feasible with model-based system design and robust artifact correction in a dedicated head CBCT system. Further improvements can be achieved with incorporation of model-based iterative reconstruction techniques also within the scope of the task-based optimization framework. David Foos and Xiaohui Wang are employees of Carestream Health
REPETTO COVERS BY REPETTO DANILO

THE COMPANY CARRIES OUT CONSTRUCTION ACTIVITIES AND IS SPECIALISED IN ROOF COVERING IN PARTICULAR USING SLATE. THE INDIVIDUAL COMPANY REPETTO COVERS REPETTO DANILO HAS BEEN OPERATING SINCE 20 JANUARY 1994 AND HAS THEREFORE ACQUIRED A GREAT DEAL OF EXPERIENCE AND EXPERTISE IN ITS FIELD WORKING. MR. REPETTO DEALS WITH THE CONTACTS WITH CUSTOMERS AND SUPPLIERS AND ALL THE ORGANIZATIONAL ASPECTS OF THE ACTIVITY. SOME EMPLOYEES ARE EMPLOYED BY MR REPETTO AND THE STAFF IS SIZED ACCORDING TO THE ACTIVITY TO BE CARRIED OUT; THE COMPANY OFTEN COLLABORATES WITH OTHER COMPANIES IN THE SECTOR FOR THE REALISATION OF PARTICULAR WORKS. FOR SOME YEARS THE COMPANY HAS ACTIVATED ITS OWN LOCAL UNIT WITH WAREHOUSE AND OFFICE IN THE MUNICIPALITY OF TRIBOGNA AND HAS ORGANISED ITSELF TO BE ABLE TO EFFICIENTLY CARRY OUT ITS ACTIVITIES.ESSA IS EQUIPPED WITH SUITABLE AND INNOVATIVE MACHINERY AND EQUIPMENT THAT ALLOW IT TO OPERATE AT ITS BEST.
Ngi program for open internet renovation

NGI-POINTER contributes to the human-centric revolution of the internet architecture by discovering NGI Architects who bring new protocols, Open software and hardware that are used to manage the internet in various use case areas: Privacy-by-design; Internet of Things; Network optimization; Virtualization and isolation; Limitations in the TCP/IP protocol suite; eCommerce security; Autonomous Network operations and control; Energy Efficiency. 

NGI-POINTER will leverage in Big Data Analytics technology provided by Linknovate to profile and scout 1.000+ oustanding researchers worldwide. FundingBox - European leader in Financial Support to Third Parties - will manage the open call mechanism on its 17.500 members strong platform. Aarhus University - a Top-100 University in the world - brings expertise in business mentoring and connections with more that 5.000 Internet researchers. Digital Workx provides the technical expertise for software and hardware standardization and ties with more that 65.000 engineers and Open Software developers around the world that are part of the Internet of Things Network. 

NGI-POINTER will provide the building blocks the pillars for a technical revolution of the internet architecture towards a more efficient, scalable, secure and resilient internet.
The role of renewable energy and natural resources for sustainable agriculture in ASEAN countries: Do carbon emissions and deforestation affect agriculture productivity?

The adoption of Sustainable Development Goals (SDG) in 2015 shifted the attention towards sustainability-related concerns in both developing and developed counties. The aim of this paper is to examine how agricultural productivity – a key driver in achieving many of these SDGs – is affected by carbon emissions, deforestation, renewable energy consumption, natural resources, and regional integration for the ten Association of Southeast Asian Nations (ASEAN) countries. Using the Mean Group (MG) class estimators, able to tackle the cross-sectional dependence in the data, empirical findings reveal that environmental degradation (in the form of CO2 emissions) reduces agricultural productivity in the region. Both the forest area and natural resource variables negatively affect the productivity of the agricultural sector, while the use of renewable energy sources positively contributes to the agricultural sector. However, despite being one of the highest integrated regions in the world, regional integration among the ASEAN members does not boost their agricultural productivity. The causality tests confirm the existence of bidirectional causality between agricultural productivity and renewable energy consumption, and unidirectional causality across a few other variables. Accordingly, the study provides policy recommendations for the governments of ASEAN economies on improving the environmental performance of agriculture and achieving the SDGs by 2030.
High throughput synthesis and characterization of the PbnNb2O5+n (0.5<n<4.1) system on a single chip

Most high throughput studies focus on assessing the effect of composition within a single known fundamental structure type, such as perovskite. Here we demonstrate how high throughput synthesis and screening can be used to establish structure–property relations in the PbO–Nb2O5 system, for which eight distinct fundamental structure types are known to exist. PbNb4O11, PbNb2O6 and pyrochlore could be easily distinguished by X-ray diffraction (XRD). However, XRD was insensitive to distortions of the pyrochlore structure and instead Raman spectroscopy was utilized to determine changes in symmetry from cubic to rhombohedral as the PbO concentration increased. High throughput screening of the capacitance revealed permittivity (er) maxima in the PbNb4O11 (er = 700) and cubic pyrochlore phases (er = 450). The er of PbNb4O11 has not to date been reported but the value for cubic pyrochlore is higher than that reported for bulk ceramics (er = 270). Initial high electric field studies also revealed exceptionally high tunability (four times that reported for bismuth zinc niobate-based pyrochlores) of the capacitance in the pyrochlore phase.