SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Characterizing microbe-specific immune responses in the pathogenesis of autoimmunity

Dysregulation in the balance of CD4+ T helper cell populations can severely alter susceptibility to a number of chronic inflammatory diseases, including inflammatory bowel disease (IBD). The incidence of IBD is dramatically increasing in Europe and worldwide and its therapy represents an important unmet medical need, since a significant proportion of patients fail to respond to currently available immunotherapies. Therefore, a better characterization of the immunological events underlying each form of IBD is of foremost importance. Increasing evidence points to the pivotal role of a dysregulated mucosal immune response to the intestinal microbiota in the pathogenesis of IBD. However, little is known about the mechanisms contributing to the generation of commensal-specific adaptive immune responses, and whether their differential localization can shape severity and anatomical extent of the disease. Indeed, the intestines comprise anatomically distinct regions that are exposed to different luminal antigens and this diversity eventually determines a regionalization of intestinal immune functions and microbiota-specific T cell responses. The aim of this proposal is to deeply characterize microbiota-specific T cell responses generated under different inflammatory conditions, in terms of differentiation, plasticity, heterogeneity, function and homing potential. To this aim, the proposed work will combine the use of CBir1 TCR transgenic mice, whose T cells recognize a microbial antigen that is immunodominant in IBD patients, and cutting-edge techniques such as single-cell RNA sequencing.
By modelling the microbiota-specific immune response in vivo in the context of gut inflammation, I will characterize the function and homing properties of microbiota-specific T cells at the population and single-cell level, aiming at identifying new therapeutic targets for the treatment of localized forms of gut inflammation.
Terrace archaeology and culture in europe

Large areas of agricultural terracing have been abandoned and are being destroyed in Europe. TerrACE will develop a transferrable methodology of archaeological protocols for understanding the creation, maintenance and use of terraces over the longue durée, thereby informing strategies for the sustainable management of these environmental-fragility hotspots. Terraces and lynchets are hallmarks of complex Prehistoric to Post-Medieval societies and were critical for the sustainability of many European societies (including the Greeks & Romans). However, we typically know less about them than any other archaeological site type, although they were one of the first transformations of natural into cultural landscapes, which in many cases persisted to the 20th century. Key archaeological questions are: how old are terrace systems, how were they used, did they reduce soil erosion and are they carbon sinks? The answers to these questions have high relevance in Europe today as terraces can combine high yields with decreased erosion and fire risk, whilst increasing social resilience and food security in the face of environmental change.

TerrACE will be a step-change in our archaeological approach by integrating a raft of new and innovative scientific techniques through an exemplary study of the creation, operation and abandonment of terraced landscapes on a N-S climatic transect of well-known/excavated terraces across Europe. TerrACE has 5 objectives; 1) improving terrace-landscape mapping, 2) multiple dating typical terrace systems, 3) determining history of use and management, 4) understanding the role of terraces in carbon storage, and 5) outreach to promote terraces as part of Globally Important Agricultural Heritage Landscapes (UNESCO GIAHS). TerrACE is only now feasible due to the development of techniques including LiDAR, direct sediment dating, palaeoenvironmental proxies, soil carbon modelling and the innovatory use of ancient DNA on terrace palaeosols.
ORTHOPEDIC DEVICE

The invention relates to an orthopedic device comprising a main part (10) with a first surface (12) which is provided with at least one adhesive region (20). At least one recess (30) is provided in the main part (10), said at least one recess (30) being at least partly formed behind the adhesive region (20) and being provided with a pressure and/or suction connection (40). The first surface (12) is designed to be at least partly suctioned into the recess (30) when negative pressure is applied in the at least one recess (30) and/or pushed out when positive pressure is applied.
CROSS-BORDER EDUCATION NETWORK 4.0

The Industrial revolution n4is on progress: Schools, Universities and SMEs are fully involved to provide necessary skills and innovation processes. The Alpine Area is involved and several local and EU actions are addressing this challenging topic. The transboarder area interested by E-EDU4.0 is on this topic with assistance and services provided by local intermediaries to SMEs, but needs additional efforts to provide necessary skills both for the educational programmes for Schools and Universities and the training actions addressed to SMEs. E-EDU4.0aims to support the Industry 4.0 process strengthening the impact of training and educational programmes with a much more effective transboarder cooperation and a better synergy concerning training and educational programmes from one side, laboratories and didactic infrastructures from the other. The project builds necessary networks of actors dealing with skills and learning programmes, organize their activities and provide necessary tools and necessary equipment to complete the instruments and the infrastructures available for the learning process both at local and transnational level. The concrete testing of the qualification programmes with local and transboarder actions addressed to SMEs and students will improve the project impact and open to new synergies and transferring actions. An overall platform with materials and mapping will support the networking, the cooperation and the durability of the project actions undertaken.
Co-Creating sustainable and competitive fruits and vegetables’ value chains in europe

Starting from current best practices and key success factors observed and analysed in innovative value chains and the state of the art in technological and non-technological approaches, CO-FRESH proposes to develop techniques, tools and insights for the re-design of agri-food value chains. Through collaborative and systemic approaches, the tools and formats will be applied in 7 pilot cases representing diverse fruit and vegetables agri-food value chains (including protein crops for food and feed) across Europe. CO-FRESH will use the Intervention Research approach to study models of collective innovation action within and across organisations.

The CO-FRESH consortium brings together key actors from pilot agri-food value chains; actors’ associations (farmers, food producers, cooperatives, consumers); experts in technological (including digital) solutions and non-technological (including social, organizational, and institutional) solutions; as well as experts in environmental, social, economic sustainability, and in consumer’s acceptance.

The main objective of CO-FRESH is to (re)design and pilot innovative systemic approaches to agri-food value chains to scale up this innovation at European level. These innovative approaches will improve economic, social and environmental performance/efficiency of these value chains, through smart integration of technological, social, organisational, managerial and institutional innovations; all of which serve to make them more sustainable.
Spagna nel cuore di Leonardo Sciascia

L'amore e l'attrazione di Leonardo Sciascia per la Spagna risalgono alla sua giovinezza e sono ampiamente testimoniati nei suoi scritti. Non c'è aspetto della Spagna che lo scrittore non abbia analizzato con la sua acutezza e lucidità, mettendo spesso in relazione le caratteristiche del Paese iberico e dei suoi abitanti con quelle della Sicilia. Attraverso le sue riflessioni, Sciascia ha sottolineato quei legami storici, culturali e antropologici che testimoniano la speciale affinità tra le due terre a lui particolarmente care.
New near-optimal codebooks associated with binary Sidelnikov sequences

In this paper, an (N, K) codebook is constructed from a K × N partial matrix with K <; N, where each code vector is equivalent to a column of the matrix. To obtain the K × N matrix, K rows are selected from a J × N matrix Φ, associated with a binary sequence of length J and Hamming weight K, where a set of the selected row indices is the index set of nonzero entries of the binary sequence. It is then discovered that the maximum magnitude of inner products between a pair of distinct code vectors is determined by the maximum magnitude of Φ-transform of the binary sequence. Thus, constructing a codebook with small magnitude of inner products is equivalent to finding a binary sequence where the maximum magnitude of its Φ-transform is as small as possible. From the discovery, new classes of near-optimal codebooks with nontrivial bounds on the maximum inner products are constructed from Fourier and Hadamard matrices associated with binary Sidelnikov sequences.
AQUEOUS ALKYLKETENE DIMER DISPERSIONS

Aqueous alkylketene dimer dispersions which contain at least 15% by weight of an alkylketene dimer and at least one water-soluble cationic starch, aluminum sulfate and at least one condensation product formed from napthalenesulfonic acid and formaldehyde or lignosulfonic acid or in each case salts thereof, wherein the dispersions, each based on alkylketene dimer, contain from 2 to 50% by weight of aluminum sulfate, and in which the dispersions, with an aluminum sulfate content of from 2 to 15% by weight, additionally contain from 0.1 to 5% by weight of a saturated carboxylic acid having from 1 to 10 carbon atoms, of benzenesulfonic acid, of p-toluenesulfonic acid and/or of a mineral acid, and the use of the dispersions as bulk and surface sizes for paper and paper products.
Prevalence and pathogen load of Cryptosporidium and Giardia in sheep faeces collected from saleyards and in abattoir effluent in Western Australia

The prevalence of Cryptosporidium and Giardia in faeces collected from sheep at sale yards in Western Australia and for abattoir effluent was determined using a quantitative multiplex PCR (qPCR). A total of 474 faecal samples were collected from sheep at two saleyards on four occasions (April-July 2014) and 96 effluent samples were collected from an abattoir over a four month period (April-July). The overall prevalence of Cryptosporidium in sheep faeces was 6.5% (31/474), with the zoonotic species Cryptosporidium parvum and Cryptosporidium ubiquitum accounting for 54.2% of the typed positive samples. Subtyping of the C. parvum and C. ubiquitum positives at the gp60 locus identified four C. parvum positives as IIdA18G1 and nine C. ubiquitum isolates as the XIId subtype. The overall prevalence of Giardia in sheep faeces was 6.3% (30/474), with the non-zoonotic assemblage E responsible for the majority (81.5%) of positive isolates typed. Median Cryptosporidium and Giardia oo/cyst concentrations in positive faecal samples were 1.7×103 oocysts g-1 (range 32-3.7×106 oocysts g-1) and 2.5×103 cysts g-1 (range 143-7.5×105 cysts g-1) respectively. Cryptosporidium and Giardia were identified in 10.4% (10/96) and 5.2% (5/96) of abattoir effluent samples (respectively). Median Cryptosporidium and Giardia oo/cyst concentrations in positive effluent samples was 1.3×103 cysts g-1 (range 393-1.5×104) and 1.5×104 oocysts g-1 (range 759-4.8×103) respectively. These findings have important implications for the sheep meat industry because Cryptosporidium and Giardia have both been associated with reduced carcase productivity in sheep, and the contamination of lamb carcases and watersheds with zoonotic species have important public health consequences.
‘Revolution forever’

This article explores the cultures of urban spaces and consumerism at the economic and cultural margins of the city. Building upon contemporary research on the efflorescence of consumerism in the wake of economic ‘liberalisation’, it focuses on the involvement of residents of the erstwhile Nangla Matchi ‘slum’ in Delhi in the activities of the ‘multilevel marketing’ company Revolution Forever (RF). The discussion proceeds through presenting a series of ethnographic vignettes relating to those who ‘work’ for the company as well as ‘seminar’ sessions organised by it. The article suggests that poor people’s work as agents of RF allows us to explore their relationships with imagined and real spaces, commitment to the notion of ‘free enterprise’ and the ways in which the company’s operational methods reproduce and reinforce the unstable worlds of the urban poor.
Synthesis and characterization of gum acacia inspired silica hybrid xerogels for mercury(II) adsorption

In a sol-gel process, gum acacia inspired silica xerogels have been synthesized from tetraethylorthosilicate. Besides showing photoluminescence under ultraviolet excitation, the hybrid xerogels were very efficient in capturing mercury(II) from synthetic solution. To synthesize the optimum sample (in terms of Hg(II) uptake), different ratios of H(2)O:TEOS:EtOH were taken at fixed GA and catalyst concentrations where 4:1:1 ratio was found to be most favorable. Calcination in air further enhanced the mercury binding capacity of this sample. Optimum sample (H4) was obtained on calcination of the gel at 600°C. The hybrids have been structurally characterized using Infrared spectroscopy, X-ray diffraction, scanning electron microscopy, thermo gravimetric analysis, photoluminescence spectroscopy and Brunauer-Emmett-Teller analysis. In a preliminary batch adsorption experiment, H4 was evaluated to be highly efficient in the removal Hg(II) from synthetic aqueous solution.
Entailing perpetuity: family, power, identity. the social agency of a corporate body (southern europe, 14th-17th centuries)

Few legal phenomena have been so relevant to premodern southern Europe societies as entails, a specific strategy that evolved to protect family inheritances, thus enabling the reproduction of elite social status. The VINCULUM project aims to explain how entailment became possible, how it functioned, and why it lasted for so many centuries. The project rests on the innovative theoretical claim that entails, as corporate bodies, functioned as a key social agent, created and acting within societies for which non-personal legal subjects were normal. Building on the Portuguese-Iberian case, and on the extensive research already carried out by me and my team, I propose to study 'entailment' as a diverse but pivotal practice, one embedded in law, aristocratic discourse, and kinship-based organization, and to carry out comprehensive analysis that explores this global nature.  The research approach systematically breaks with traditional research frontiers: cases will extend from the 14th to 17th century in both continental and Atlantic spaces, and include both comparative perspectives and the study of later social reconfigurations.

VINCULUM will be anchored in extended research in public archives and on unprecedented access to extensive private family archives, which have been opened to research by the ARQFAM program I have led since 2008. Data collection will allow for the construction of a large database, gathering all documents relating to each entail, under a theoretical model that seeks to reconstruct past information systems, thus testing a novel methodology developed in my previous research. The database that will gather c.7000 entails, enabling systematic inquiries organized around the new conceptual definitions proposed by the project. The research will be strongly interdisciplinary, engaging with historical anthropology and archival science in order to construct a proper theoretical model for understanding this crucial legal and social phenomenon.
Three-dimensional spiral computed tomographic cysto-urethrography for post-traumatic complex posterior urethral strictures associated with urethral-rectal fistula

To evaluate the value of three-dimensional spiral computed tomography/cysto-urethrography (CTCUG) in diagnosing posterior urethral strictures associated with urethrorectal fistulas (URF). Between June 2008 and March 2012, 38 patients with posterior urethral strictures associated with URFs were examined by CTCUG, retrograde urethrography (RUG) and cysto-urethrography (CUG). Urethral reconstruction was undertaken and URFs were surgically repaired in all patients. The length of the urethral defect, location and size of URFs were recorded. Data from radiological examinations were compared with surgical findings. No statistically significant difference was found in the length of stricture measured using CTCUG (4.31 ± 2.28 cm) or conventional urethrography (4.02 ± 3.12 cm; p > 0.05), However, the accuracy in determining the location of the stricture was higher with CTCUG (93.12%) than with conventional urethrography (70.59%; p < 0.05). CTCUG identified URFs in all 38 patients (100%), whereas URFs were only observed in 27 patients (71%) using conventional urethrography. In conclusion, CTCUG was more accurate, safer and provided more details of URFs and urethral defects than conventional urethrography in patients with posterior urethral strictures associated with URFs.
Nitrogen Release from Coated Urea Fertilizers in Different Soils

The nitrogen (N) release from coated urea fertilizers (Arborite and ESN), traditional N fertilizers [urea, (NH2)2CO], and urea ammonium nitrate (UAN) [(NH2)2CO, NH4NO3] in three North Carolina (USA) soils was measured throughout a 12-week laboratory incubation. Treatments were N source and moisture level (60% and 80% of field capacity). In both the Candor and Cecil soils, 40% of the Arborite N had released by day 2 after addition to the soil. Maximum Arborite N release was achieved by week 6 for both soils. The ESN N release began between weeks 1 and 2, and maximum release was attained by week 6 for the Candor and by week 8 for the Cecil soil. The ESN reached 70% release on Portsmouth by week 8 and Arborite had an immediate release. Field studies of these coated ureas would be needed to determine if they are economically viable over more traditional N fertilizers in North Carolina.
Estimating the aggregate value of forest recreation in a regional context

Public goods and services supplied by nature require active government intervention to ensure their provision. Nevertheless, prior to the implementation of any policy, planners should compare the costs and benefits caused by their decisions, a difficult task when policies and regulations are developed at a regional or national level (i.e. fire and pest control policies included in forests national plans), and their impacts spread out across a large number of people and ecosystems. In this context, although environmental economics has provided the necessary information for decision-making guidance related to site-specific interventions, little attention has been given to the information requirements of policies affecting large geographical areas, that is, to the estimation of an aggregate value for a specific region. The purpose of this paper is to improve current applications, inferring the recreational value of forests through the implementation of a discrete-count linked model including all the forest areas in the region of Mallorca (Spain).
Aptidões biofísicas e intensificação agroecológica da pecuária leiteira em assentamentos da Amazônia brasileira

Melhorar as atividades agrícolas e a proteção dos recursos naturais, especialmente na Amazônia e nos perímetros de reforma agrária, concebendo sistemas sustentáveis a partir de paisagens ecoeficientes é uma alternativa promissora e está sendo implantada em Paragominas, no Pará, a partir do Plano Municipal de Inteligência Territorial. Este artigo analisa em que medida o microzoneamento proposto no Plano é coerente com as possibilidades de intensificação agroecológica da produção forrageira em propriedades leiteira familiares, e se os ajustes de uso da terra correspondem às aptidões biofísicas das propriedades. Este estudo de caso foi realizado na Comunidade de Nova Jerusalém, do Assentamento Luiz Inácio e se apoiou nos dados georreferenciados do Plano Municipal, além de entrevistas com as famílias e acompanhamentos de experimentos de produção forrageira agroecológica em campo. utilizamos o software Arcgis © para compilar e cruzar informações espaciais em formato shape. Os resultados apontam que na comunidade estudada 56% das famílias têm condições favoráveis para seguir o Plano, dada as aptidões nas suas propriedades, mas há famílias em que a propriedade se encontra em condições biofísicas restritas para produção forrageira e uma atenção especial deve ser dada a este grupo.
Reflections on Love’s Spirals

This article seeks to explore how the experience of love and its expression might inform and guide reflection and inquiry into love. Despite the importance of love in our personal and professional lives, it remains a topic that has further scope for inquiry within nursing circles. The article takes as its catalyst an encounter that emerged out of a piece of research that was exploring individuals’ experiences of becoming healers and the journey they undertook. One participant spoke deeply and profoundly of his experience of love, which generated for me a personal, experiential, and intellectual process of inquiry. The article seeks to try and create a synthesis between rational inquiry and subjective experience. It explores W. B. Yeats’s notion of a gyre, a spiral, as an image and metaphor for integrating different conceptions and understandings of love. It seeks to illustrate how a more integrated understanding of love may open up spaces of inquiry that are more flexible, creative, and spontaneous.
KONSOLIDIERUNG DER BEREITS ERWORBENEN AUSLANDSMÄRKTE UND START NEUER KOMMERZIELLER KOOPERATIONEN ZUR EINFÜHRUNG NEUER PRODUKTE FÜR NEUE LÄNDER UND MÄRKTE.

KONSOLIDIERUNG DER BEREITS ERWORBENEN AUSLANDSMÄRKTE UND START NEUER KOMMERZIELLER KOOPERATIONEN ZUR EINFÜHRUNG NEUER PRODUKTE FÜR NEUE LÄNDER UND MÄRKTE.
Stochastic optimisation-based valuation of smart grid options under firm DG contracts

Under the current EU legislation, Distribution Network Operators (DNOs) are expected to provide firm connections to new DG, whose penetration is set to increase worldwide creating the need for significant investments to enhance network capacity. However, the uncertainty around the magnitude, location and timing of future DG capacity renders planners unable to accurately determine in advance where network violations may occur. Hence, conventional network reinforcements run the risk of asset stranding, leading to increased integration costs. A novel stochastic planning model is proposed that includes generalized formulations for investment in conventional and smart grid assets such as Demand-Side Response (DSR), Coordinated Voltage Control (CVC) and Soft Open Point (SOP) allowing the quantification of their option value. We also show that deterministic planning approaches may underestimate or completely ignore smart technologies.