SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Resolution of Sample Heterogeneity in Solid-State NMR Dipolar Recoupling and Magic Angle Spinning Sideband Analyses

We have engineered algorithms to characterize heterogeneous distributions of chemical shift tensor parameters from magic angle spinning sideband intensities, as well as distances from rotational-echo double-resonance (REDOR) data. In the case of REDOR data, the method can reveal multiple distances with relatively few data points, which is of particular benefit in application to biological systems. This reverses the common practice of comparing REDOR data to dephasing curves simulated for several preconceived structural models, by providing the information necessary to construct models based on unbiased data analysis. In the case of chemical shift tensor analysis, it allows arbitrarily complex phospholipid mixtures to be analyzed for subtle perturbations, for example by association with antimicrobial peptides.The method uses an adaptation of Boltzmann statistics maximum entropy, and provides for a model-free approach to data analysis, as one need not assume the presence of any specific number of different chemical shift tensors or distances that contribute to observed signal. The strategy differs from the more common practice of including a single weighted term in a fitting procedure, as each datum constitutes additional “information” and independently adds to or subtracts from the entropy of the distribution. A constrained optimisation problem with 100s of unknowns (the number of points used to approximate a continuous probability distribution of the desired parameter(s)) is thereby turned into an unconstrained optimisation problem with one coefficient for each data point.The Boltzmann Statistics method also offers intriguing philosophical implications -- it gives the broadest, and perhaps most “honest” probability distribution consistent with the data, but also helps to determine which data points hold the greatest information content, such that experimental time can be focussed on gaining the best signal-to-noise where it is likely to benefit most.
A comparison of basal reflectivity and ice velocity in East Antarctica

Abstract. Ground-based radio echo sounding data acquired along the 1700 km US-ITASE traverse have been used to determine ice attenuation and relative basal reflectivity across the major catchments funneling ice from East Antarctica to the Ross Ice Shelf. We find that basal reflectivity varies locally by up to 40 dB which we interpret as due to changes in the phase state at the bed. Some, though not all, areas of high local reflectivity are observed to have flat-lying bed reflections indicative of sub-glacial lakes. We compare basal reflectivity to ice balance velocity and find a general association of higher flow speeds with high radar reflection strength. This set of observations from two independent remotely sensed geophysical data sets extends the range of field observations to the interior of East Antarctica and confirms the importance of basal lubrication on modulating the ice dynamics of the largest ice sheet on the planet.
A Smart City Scenic Spot Construction Scheme

To provide tourists with a good experience and enhance the value of natural resources, the construction of intelligent scenic spots has become the urgent task of the rapid development of tourism in China. In this paper, we first analyze the basic concept and demand analysis for a smart city scenic spot. Then, the construction framework and key implementation technologies of the smart scenic spot are given. Finally, the key technologies of the intelligent scenic spot are discussed, including ZigBee technology, video splicing, and integration, the internet protocol (IP) network public address. This construction scheme provides a new choice for the construction of intelligent scenic spots in China.
Soft-Bodied miniature mobile robots

Untethered mobile milli/microrobots would have a radical impact in medicine. Such untethered tiny machines could access smaller regions inside the body, remain inside the body for long durations as semi-implantable medical devices, and enable diagnostic and therapeutic medical operations in hard or currently not possible to reach regions inside the body with minimal or no invasion. While many groups have been working intensely on creating such new machines for potential medical applications, there are still many significant challenges that must be addressed: 3D design, fabrication and materials of safe and multi-functional medical mobile robots down to tens of micrometer size scale, robust locomotion of these robots inside the complex human body, precise navigation control under medical imaging modalities, integrating diagnostic and therapeutic medical functions to them, and demonstrating their clinically relevant medical applications in in vivo animal models.   To address these challenges, we propose to create new soft-bodied mobile milli/microrobots with medical functions and sizes down to tens of micron scale to address the above challenges of untethered miniature robots. Such shape-programmable tiny soft machines will be created from biocompatible magnetic soft composite materials, will be actuated by external magnetic fields or gradients, will have multimodal robust locomotion capability, integrated medical functions and safe interactions inside the human body, will be tracked by real-time medical imaging systems, and will be demonstrated in clinically relevant active local cargo (e.g., drug) delivery, remote heating-based coagulation and hyperthermia, and deliberate vessel and tube clogging applications. Research tasks of the robot design, fabrication and materials, robot actuation, locomotion and control, robot medical functions, and robot characterization and in vitro, ex vivo and in vivo testing will be performed to achieve our research objectives.
6-heterocyclic-4-amino-1,2,2A,3,4,5-hexahydrobenz[CD]indoles

6-Heterocyclic-4-amino-1,2,2a,3,4,5-hexahydrobenz[cd]indoles are provided which are useful in modifying the function of serotonin in mammals.
Forward and backward to mid-rapidity correlations measured in d+Au collisions at with the PHENIX detector

Abstract Deuteron-gold collisions provide the opportunity to probe the partonic structure of the Au nucleus, measuring a valuable baseline for Au+Au collisions. There are strong theoretical and experimental interests in the possibility of gluon saturation effects, which could influence parton distributions at very low x in the nucleon. These effects would be even stronger in a nucleus and can be investigated via d+Au collisions, particularly with the PHENIX forward detectors, which can access x ≈ 0.005 . Comparison of the mid-rapidity yield correlated with jets triggered on the d going side to the yield correlated with those triggered on the Au going side allows exploration of gluon saturation and other x dependent effects. The status of this analysis will be presented.
The brexit effect in media coverage: how the intra-party democracy counters the rise of european populism

The main objective of the research is to conduct a pilot study in UK aimed at investigating the phenomenon of populism after the Brexit referendum, explaining how the intra-party democracy and deliberation can defuse its growth.
In that respect, the research will consist of two distinct steps: 1) to analyse the media coverage after the Brexit referendum in order to identify populist issues; 2) to observe how party members elaborate these populist issues.
As to the first step, analysis of media coverage, I will examine the interpretative frames that politicians, journalists and observers relied upon within the public debate. In particular, I will focus on the news about Brexit in a populist perspective and on its relevance after referendum in the public debate. As regards the second step, particular attention will be paid to the
party members in order to examine how they elaborate 'populist' issues in a deliberative process.
The importance of the study lies in the originality of the object under analysis. UK is an ideal case study for understanding the adaptation of populism in the European context and analyzing whether and how the intra-party democracy are able to counter the rise of phenomenon.
The study has the potential to be expanded nationwide or into a comparative cross-country research. In fact, the research results will be used to analyse the next elections to European Parliament, understanding which policy “mechanisms” are able to contain populism impact on the European institutions.
Find your passion for science on researchers night

Institute of Animal Reproduction and Food Research of the Polish Academy of Sciences (IAR&FR), in partnership with Olsztyn School of Higher Education (OSHE) invites kids, tweens, teens and adults to join FUSION Researchers’ Night – a unique occasion when science, entertainment and education meet in one place! Fusion Night is an incredible blend of research, innovation, fun and education that introduces young people to meet scientists who live in their city but whose work reaches across the whole world. 
The FUSION Night (FN) programmes revolves around the activities that will increase the awareness of the community at large about the importance of research careers and the central role of scientists in improving the daily life and well-being of European citizens. Visitors of the FN will have a chance to join edutaining activities, become a researcher for one night and give lecture to their peers (Polish Academy of Kids), test the content of vitamins in juice or milk (“Vitamins fusion or health illusion?), discover the secrets of cryopreservation in a mobile laboratory (“Ice land”), develop their own creams using fruit powders (“Tasty skin”), design a book from scratch (“Night in the Library”), learn the secrets of animal biodiversity (“Take a walk on the wide side”) or make a fruit puree in liquid nitrogen (“Molecular Show of Fusion Kitchen”). Sport enthusiasts can expect swimming competitions, basketball game, salsa course and martial arts training all conducted by our young researchers. We haven’t forgotten about the music and art lovers too, preparing for them a live concert of an international group of English teachers and an exhibition of science curiosities captured on the stained glass. Collaboration with partners from industrial circles will help to provide visitors with a first-hand view of the products and innovations “born” thanks to the solutions provided by science and researchers.
Nation – power – subjectivity: the making of national subjects in late medieval bohemia and brabant (1300-1450)

This research project will challenge classical assumptions of the formation of the nation, traditionally seen as inseparable from industrialisation and the rise of capitalism in the 18th century. This project will show that the nation had already become a source of legitimacy in the late medieval power struggles between sovereign and political society on the one hand, and between different factions in that society on the other. Thus, the medieval nation was a ‘fundamental political factor’ and cannot be reduced to a simple cultural or ethnic notion. But, in order to exist, a nation needs individuals to identify with it. The national project depended on popular involvement based on the ideology on the ‘common good’ and of a sense of community. This project intends therefore to consider both individual and collective factors in the making of the nation. It will use a transnational approach, comparing the Kingdom of Bohemia and the Duchy of Brabant between 1300 and 1450. Both entities shared, for a while, the same ruling family and belonged to the Holy Roman Empire. Both were characterised by a strong social group competing with the sovereign and by complex linguistic arrangements with social and political implications. They both developed a significant sense of the nation, albeit differently due to distinct socio-political balances and experiences. While the Czech nation, as a product of the Czech nobility, was associated with feudal and conservative values, that of Brabant was linked to the urban ideals of political representation and liberty. Instead of starting from a fixed definition of the nation, the project will stress its contingent nature through an ‘archaeology’ that retraces the different contexts that gave rise to it and its different uses. The enquiry will be based on a large corpus (chronicles, didactic and courtly literature, songs, hagiography, etc.) that reflects the different positionings within society leading to the making of national subjects.
Decadal variations of the North Equatorial Current in the Pacific at 137°E

Hydrographic observations, ocean state estimates, and ocean objective analyses are combined to investigate the decadal variations of the North Equatorial Current (NEC) in the Pacific at 137 degrees E during the last three decades (1975-2005). Observations show that the decadal NEC transport has three maxima around 1980/1981, 1994/1995, and 2004/2005, and two minima around 1989/1990 and 1999/2000, respectively. Associated with these maxima/minima, the sea surface height (SSH) falls/rises and the subsurface isopycnals shoal/deepen in the southern part of NEC, resulting in westward/eastward zonal velocity anomalies. Results from the ocean state estimates and ocean objective analyses show good agreement with observations. Further analysis indicates that the observed zonal velocity anomalies at 137 degrees E are part of the cyclonic/anticyclonic gyre anomalies formed in the tropical northwestern Pacific east of the Philippines, coinciding with the tropical gyre. Results from a 11/2 layer reduced gravity model suggest that these oceanic variations are mainly controlled by the decadal wind forcing in the tropical western Pacific and can be attributed to both local Ekman dynamics and baroclinic Rossby wave propagation.
Karos – integration of a dynamic and predictive short distance carpooling offer into route planner services

In Europe, 70% of commuters drive a car to go to work. In 90% of cases, regardless of the geographical area, the occupation ratio of a car for such commuting trips is 1:1. In the Paris region alone, this means that there are 40M seats that remain unused every day. Whilst, governments are focusing on spelling out policies to develop more sustainable urban mobility grids, the stunning success and strong growth of carpooling service websites, such as BlablaCar, Europe’s leader on long distance carpooling (growing from 3 to 10 millions of users Europe-wide), signals that the sharing-economy heralds a shift in consumer attitudes and could provide a solution to sustainable intra-city mobility. Yet, current solutions to facilitate are pooling are not-adapted to intra-city commutes. They are Geared to the Long-distance, Non-Intelligent/Automated, Inflexible and lacking critical mass: and Non-transparent.

KAROS is a smart mobility platform, leveraging big data technologies, Artificial Intelligence and algorithms. The strength of KAROS lies in its commercial approach. Unlike usual B2C carpooling services, KAROS operates in an indirect model to reach its end-users, by striking partnerships with companies (>500 employees), which partly subsidise the service, in order to offer more convenient and comfortable means of transportation to their employees, at lower costs. This in turn, enables KAROS to reach large numbers of users through each partnership, as they act a multipliers and strong communication channels to promote the service. Because of these unique advantages, since January 2016, with no marketing, KAROS now counts over 25K users, 3600 of whom are active on a weekly basis.The objective of the feasibility study is to prove technical and commercial viability, and to assess KAROS expansion in other EU Markets.
Electrolyte Pumping Optimization in Already Manufactured Vanadium Redox Battery Based on Experimentally Determined Electrical and Hydrodynamic Losses

AbstractHerein is presented an optimization of electrolyte pumping systems in industrial vanadium redox flow batteries (VRBs). The main advantages of the VRB relate to its prolonged service life, outstanding dynamic response, and flexible controllability during charge/discharge processes. In spite of their exceptional electrical parameters, VRBs suffer from significant energy requirements in the hydraulic pumping system needed for circulation of electrolyte from external tanks to battery cells. The industrial VRB equipped for this purpose with centrifugal driven by controllable electric motors hydraulic pumps were made from plastic components and able to work in the aggressive acid electrolyte. Electrolyte flow is carried out through the entire hydraulic system and battery cells containing carbon electrodes and providing electrochemical reduction-oxidation reactions of vanadium ions. Currently, electrodes in the VRB are made from carbon felt material because its porous structure possesses high specific su...
Energy mix optimization from an energy security perspective

Abstract In this article, an integrated methodology is presented to assess an optimal mix and perspective development of energy generation technologies not only by technical, economic or other criteria, but also from an energy security perspective. The energy security is evaluated in terms of energy system resistance to disturbances. The methodology comprises several models, such as a stochastic model of energy systems disturbance parameters, economic-optimization model of energy systems functioning, metric and analysis techniques of energy security. The perspective development and functioning of the energy systems with stochastic disturbances is modelled using economic-optimization model with the development of different energy generation technologies. An open source energy modelling system is used as a tool for this model. The concept of energy security coefficient, which is calculated to assess energy security in terms of energy price increase and the amounts of unsupplied energy due to the disturbance consequences, is presented in the article as well. The developed methodology is applied to the case study of the reference energy system. Its various development scenarios with different energy generation technologies are analysed according to the share of technologies in the energy production. Scenarios are simulated in the stochastic environment of various disturbances and results are obtained in terms of variation of energy security coefficient over time by comparing scenarios from the energy security point of view. Finally, the results of the development scenarios are discussed, threshold shares in the energy production and optimal mix of energy generation technologies in terms of energy security are proposed, limitations of the case study are identified and some general conclusions are given.
Getriebe und Gasturbinentriebwerk

Es wird ein Getriebe (30) mit einem drehbar gelagerten Bauteil (34) beschrieben, das mit wenigstens zwei annähernd rotationssymmetrischen Rinnen (41, 141) ausgebildet ist, in die jeweils ausgehend von ihrem radial inneren Bereich (42, 142) Öl aus jeweils einer gehäusefesten Ölzuführung (44, 144) einleitbar ist. Die Rinnen (41, 141) weisen jeweils in wenigstens einem radial äußeren Bereich (45, 145) jeweils wenigstens eine Auslassöffnung (46, 146) für das Öl auf. Des Weiteren ist das Öl von den Auslassöffnungen (46, 146) jeweils zu wenigstens einem hydraulischen Verbraucher über jeweils wenigstens einen Leitungsbereich (47, 147) führbar. Darüber hinaus wird ein Gasturbinentriebwerk mit dem Getriebe (30) vorgeschlagen.
Small molecule compounds targeting miRNAs for cancer therapy

One of the most fascinating discoveries in molecular oncology has been that cancer represents a disease in which genetic alterations in protein-coding, but also in non-coding genes complement each other. MicroRNAs (miRNAs) are a type of non-coding RNA (ncRNA) transcripts that can regulate gene expression primarily by disrupting messenger RNA (mRNA) translation and/or stability, or alternatively by modulating the transcription of target mRNAs. For the last decade, miRNAs have shown to be pivotal characters of every single one of the cancer hallmarks. Profiling studies have proven the significance of identifying over-expressed miRNAs (oncomiRs) causative of the activation of oncogenic pathways that lead to malignancy. Due to their crucial role in cancer, it has become a challenge to develop efficient miRNA-inhibiting strategies such as antagomiRs, locked nucleic acids or antisense oligonucleotides. However, to this date, the accessible delivery agents and their pharmacokinetic/pharmacodynamic properties are not ideal. Thus there is an urgent, unmet need to develop miRNA-based inhibitory therapeutics. Herein we present a novel therapeutic strategy that is only at the tip of the iceberg: the use of small molecule inhibitors to target specific miRNAs (SMIRs). Furthermore we describe several high-throughput techniques to screen for SMIRs both in vitro and in silico. Finally we take you through the journey that has led to discovering the handful of SMIRs that have been validated to this date.
The prussian fathers of greek military history

How do our views on war affect the way we write history? The study of Ancient Greek warfare – and the strong moral judgments that have always been part of it – remains heavily influenced by the pioneering works of Prussian and Imperial German scholars, whose outlook was profoundly nationalist and militarist. The views of these scholars on Greek strategies, tactics and rules of engagement are still perpetuated in modern scholarship. New ideas have only started to gain ground in the last decade. Recent historiographical studies suggest that experts in the field are unaware of its founders’ legacy; the early scholars of Greek warfare have never been studied in their own right.

The proposed research is a detailed look at the major German handbooks that appeared between 1852 and 1931 to form the foundation of the academic study of Greek warfare. It will place these works in their intellectual context by examining the life and intellectual environment of their authors. It will analyse the way these scholars’ backgrounds affected their view of history. Finally, it will trace the afterlife of their views as they were transformed from a didactic tool in the instruction of Prussian officers to an ideological weapon in the hands of American neoconservatives.

This project will use the development of scholarly interpretations of ancient military methods as a reflection on changing modern attitudes to war. How do our perspectives and those of our predecessors affect our research? The professional militarism of the German scholars shaped their perception of Greek warfare as restricted and primitive; later generations, who found war more abhorrent, adapted these conclusions into an idealised image of the past, giving ideological and political power to the Germans’ harsh and unjustified conclusions.