SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
The Budding Yeast “Saccharomyces cerevisiae” as a Drug Discovery Tool to Identify Plant-Derived Natural Products with Anti-Proliferative Properties

The budding yeast Saccharomyces cerevisiae is a valuable system to study cell-cycle regulation, which is defective in cancer cells. Due to the highly conserved nature of the cell-cycle machinery between yeast and humans, yeast studies are directly relevant to anticancer-drug discovery. The budding yeast is also an excellent model system for identifying and studying antifungal compounds because of the functional conservation of fungal genes. Moreover, yeast studies have also contributed greatly to our understanding of the biological targets and modes of action of bioactive compounds. Understanding the mechanism of action of clinically relevant compounds is essential for the design of improved second-generation molecules. Here we describe our methodology for screening a library of plant-derived natural products in yeast in order to identify and characterize new compounds with anti-proliferative properties.
A Critique of Sumner's Account of Welfare

Wayne Sumner, in the first six chapters of his excellent book Welfare, Happiness and Ethics , argues for what he calls an authentic life satisfaction theory of welfare. Somewhat generally, Sumner's theory of welfare is a sophisticated subjective account that treats one's happiness of a certain sort, and in the right conditions, as enhancing one's welfare. In this essay, I critically explore Sumner's account of welfare. I argue that Sumner's arguments for his own account of welfare, when followed to their logical conclusion, support a position which is slightly, but significantly, different from his own position. Additionally, I argue that Sumner's account of welfare has several counter-intuitive implications. I conclude that his account is seriously flawed.
Literatura y diversidad en la formación docente: el aula de Magisterio como espacio de reflexión

The presence of diversity in our schools is undoubtedly one of the great educational challenges of our time: therefore, the training received by future teachers also must be in the focus of our concern. In this paper we intend to approach the ideas and beliefs of Teaching students about children's literature as a tool for work on diversities and as an element directly linked to dialogue and empathy so that all lives can be lived, avoiding any form of violence against those who are perceived as different. Starting from a classroom experience carried out with Teacher Training students from the University of Valencia (Spain), we will reach convincing conclusions about their own perception of the deficiencies in university education and also about the potential of children's literature in this task that involves the entire educational community, which will undoubtedly help when introducing diversity transversely in teacher training.
A Masters level teaching profession: a study of the rationale for the Masters level Postgraduate Certificate in Education, a Masters level teaching profession and the Masters in Teaching and Learning and the perceptions of key stakeholders in the English West Midlands

There has been a significant shift in initial teacher training (ITT) and teachers’ professional development (PD) to include masters level (M level) study in recent years in England and this research investigates aspirations for the M level teaching profession, providing a rationale for the M level Postgraduate Certificate in Education (PGCE), a masters level profession and the Masters in Teaching and Learning (MTL) and providing the perceptions of key stakeholders. Although these initiatives represented a major shift in the training and development of teachers, only limited consideration has been given to these areas, despite the plethora of research regarding ITT and teachers’ PD. Findings suggest that HEIs superimposed their own rationale for these initiatives, in addition to the imposed rationale. Findings also indicate that universities consider M level ITT and PD to have many benefits, but there was much scepticism regarding the MTL. Furthermore, although trainees and newly qualified teachers (NQTs) were positive about M level study in principle, especially when there was an element of choice, they were sceptical regarding its benefits to practice and considered M level to be more important later in their careers, due to their more immediate concerns to meet statutory professional requirements.
Analysis of Message Passing Programs Using SMT-Solvers

AbstractWe consider message passing programs where processes communicate asynchronously over unbounded channels. The reachability problem for such systems are either undecidable or have very high complexity. In order to achieve efficiency, we consider the phase-bounded reachability problem, where each process is allowed to perform a bounded number of phases during a run of the system. In a given phase, the process is allowed to perform send or receive transitions (but not both). We present a uniform framework where the channels are assigned different types of semantics such as lossy, stuttering, or unordered. We show that the framework allows a uniform translation of bounded-phase reachability for each of the above mentioned semantics to the satisfiability of quantifierfree Presburger formulas. This means that we can use the full power of modern smt-solvers for efficient analysis of our systems. Furthermore, we show that the translation implies that bounded-phase reachability is np-complete. Finally, we prove that the problem becomes undecidable if we allow perfect channels or push-down processes communicating through (stuttering) lossy channels. We report on the result of applying the prototype on a number of non-trivial examples.
Mediterranean Innovation STRAtegy for transnational activity of clusters and networks of the Blue Growth

The current MED area innovation performance in the blue growth (BG) sector is behind the EU average and there is a lack of transnational and transversal cooperation between the different quadruple helix actors in the BG. The aim of MISTRAL is to strenghten a transnational partnership made up of 8 countries (2 Ministries, 8 Regions, 5 Clusters, 3 RTOs and other organizations) in order to: i) make marine knowledge and sustainable innovation the key drivers for BG, ii) support MED clusters to become an excellent intermediary of knowledge for increasing blue economy, iii) design and implement sustainable development trajectories harmonised with the MED regions Smart Specialization Strategies. The strong partnership, thanks to the open innovation approach, will act as catalyzer for cooperative sustainable innovation actions, placing MISTRAL in a unique position to help the boost of the BG sector in the MED area responding to the programme challenges. A clustering innovation service pack for BG clusters and operators will improve the innovation performance of at least 300 SMEs with at least 100 experts benefitting from the transnational activities and exchange programmes on capacity building. MISTRAL has the ambition to develop a wider governance vision towards 2020 in the BG sector as well as assuring the effective policy mainstreaming. In conclusion, MISTRAL will be the Blue Innovation wind in the MED area unlocking the innovation potential of the coastal and marine ecosystem.
Sostegno alle piccole imprese con un fatturato superiore a 500 000 BGN per far fronte alle conseguenze economiche della pandemia di COVID-19

Sostegno alle piccole imprese con un fatturato superiore a 500 000 BGN per far fronte alle conseguenze economiche della pandemia di COVID-19
Control of current-induced heat exchange in molecular junctions by molecular scale design of the electronic properties

The project will investigate the current-induced vibrational heating and cooling of molecular junctions with relatively sharp molecular resonances. These systems are interesting because, depending on the atomistic details of the metal/molecule interface and the chemical structure of the molecule, an extremely rich variety of heating/cooling dynamics under an external bias is possible.
A detailed study of the connection between the electronic structure (both at equilibrium and in presence of a bias) and the inelastic processes associated to the emission and absorption of molecular vibrations represents a necessary step toward the comprehension and control of the junction heating and cooling dynamics and thus of its stability.
We will study a broad range of systems where the sharp DOS features are originated by two different physical mechanisms: i) structural and chemical details of the metal/molecule interface, and ii) destructive interference in the molecule.
In the first case, we will focus on the effect of electrode shape on the heating and cooling of the molecule and consider a wide range of molecule-electrode couplings. The molecules we will consider are examples of these classes of systems, namely carbenes (strong coupling to the electrodes), bypiridine (intermediate coupling), PTCDA (weak coupling).
In the case of destructive interference, we will focus on conjugated linear molecules where quantum interference features originate from the coupling of side-groups to the molecular backbone.
Finally the project will extend the state-of-the-art approach for the calculation of the heating and cooling dynamics by introducing self-consistency between vibrations populations and the electronic structure. For this we will make use of a series of approximations in the derivation of the equations for vibration emission and absorption rates. We expect this new approach will reveal complex dynamics in systems with sharp resonances and close to vibrational instabilities.
Method and device for securing cylindrical loads

A heavy, open ended roll of paper (1) which is wound on a hollow core is transported on a flatbed (8) truck (6) to which it is secured by straps (7) secured to the vehicle. The roll is secured by a two-part (12a, 12b) fixture passing (12) through the co-axial core. The fixture has edge-protectors (10a, 10b) each side of the vehicle, to which the straps are secured. The two-part (12a, 12b) fixture is joined at the mid-point by e.g. a dovetail joint (28) where it is supported by a short hollow column (11).
Dementia prevention: imaging risk in primary care and catalysing behaviour change

Based on scientific findings from University of Oxford, and combined with the latest neuroimaging technologies, Mind over Matter is developing a ground-breaking technological solution to ignite and support a global dementia prevention movement.

The low-cost technology comprises three parts:

1.        A headband with a small number of novel neuroimaging sensors, to allow the level of brain inflammation – a biomarker of future dementia risk – to be inferred completely non-invasively and in the ubiquitous primary care / general practice setting.

2.        Clinical software which combines this assessment of brain inflammation levels with an assessment of the individual’s clinical risk factors (diabetes, hypertension, smoking habits, exercise levels, eating habits, etc.) to generate a personalised score of their risk for developing dementia in later life.

3.        An intelligent behavioural change app prescribed to the individuals assessed as being at greatest risk of developing dementia in the future, supporting the individual to optimise their lifestyle so that they reduce this risk by up to 50%.

The major objective of this Phase 1 SME Instrument feasibility project is to answer the following questions, progressing from technology readiness level (TRL) 3 to 5:

Technical Question: “Does the unique information about an individual’s risk for developing dementia available from measuring brain inflammation using the headband (as compared to the information available from knowing clinical risk factors only) increase predictive power sufficiently for clinicians to prescribe a dementia prevention strategy?”

Commercial Question: “Could the total solution be manufactured for a price that potential customers would be willing to pay?”

The major output is a business plan that draws on the answers to these technical and commercial questions to design and prepare for the Phase 2 project. The Phase 2 project would last 24 months and develop the technology from TRL 5 to 7.
SMART & START - LUDWIG SRLS

IN UN MOTORE DI RICERCA LINGUISTICO CHE AIUTA A SCRIVERE CORRETTAMENTE IN INGLESE E STIMOLA L'APPRENDIMENTO DELLA LINGUA
Falling research in the NHS

A clear national strategy is needed to overcome local barriers to research

The recently published Department of Health leaflet entitled A Junior Doctor’s Guide to the NHS includes a statement that the director general of research and development is responsible for establishing the NHS as an international centre for research excellence.1 Although medical research in the United Kingdom is clearly excellent and world leading, the NHS has underperformed as a leader in clinical research. In 2003 a government sponsored report described how the NHS would be transformed to produce high quality global clinical trials, giving the UK a competitive edge in clinical research.2 Unfortunately, the UK’s participation in global clinical trials dropped from 6% in 2002 to 2% by 2009.3 Other initiatives to support clinical research have also failed to stimulate research by NHS clinicians, including the establishment of the UK Clinical Research Collaboration in 2004, and the inauguration of the NHS research and development strategy under the auspices of the National Institute for Health Research in 2006.4

Despite concern that the introduction of the European Clinical Trials Directive might negatively influence …
KEY SAFE ASSEMBLY AND KEY SAFE MANAGEMENT SYSTEM

The present invention concerns a key safe assembly and key safe management system, the assembly (1) comprising: a main body (4); a key drawer (16) housed in said main body; locking means for releasably locking the drawer in said main body; input access means (14) for enabling input of one or more access codes to release the locking means to allow access to the contents of the key drawer; and a data connection interface (15) for uploading and downloading data relating to said access codes. In the system a plurality of electronic lockable key safes are provided for holding keys allowing access to properties at different locations, each key safe having a data connection interface for inputting and retrieval of data relating to access codes and historic use thereof.
Economic assessment of use values of near-natural forestry compared with rotational forestry in Denmark

The present study is a cost-benefit analysis of converting the current rotational forestry (RF) of Norway spruce stand into near-natural forestry (NNF) of beech, based on two representative soil conditions and visitors popular case areas in Denmark, considering welfare economic values of timber, recreation provision, and groundwater recharge. The study answers the major research question of how large the welfare economic values of recreation and groundwater benefits of the conversion are as compared with timber benefits. The net present values (NPV) of the benefits were calculated for an infinite time horizon at a 3 % discount rate. The results reveal that converting into NNF would result in a NPV of at least 6,832 € ha−1 from use values of recreation and water benefit on a site with good soil and a high visitor frequency, as is typical in the eastern part of Denmark. On a site in the west of the country, with poor growth conditions and a lower visitor frequency, the gain is still substantial, namely 5,581 € ha−1. These benefits though come at a cost of 3,375 and 6,206 € ha−1 from timber production, respectively. This means that the economic value of use values of recreation and water benefits outweighs the loss of timber on good soil conditions but not on poor soil conditions.
Microbial therapy against gut inflammation

Gut microbiota support intestinal tract development, immune system maturation, and protection against pathogens. Imbalanced microbiota (dysbiosis) has a role in inflammatory bowel disease (IBD). To control inflammation, patients take antibiotics, exacerbating dysbiosis, leading to loss of colonization resistance against pathogens and proliferation of pathobionts, disease development and progression. Microbiota composition has, therefore, a very important role in host health, and strategies to manipulate this composition are lacking. Microbiota-produced molecules, like quorum sensing (QS) signal autoinducer-2, can influence gut composition. Bacteria use QS to regulate populational gene expression. We intend to take advantage of microbial interactions mediated by QS to tackle IBD dysbiosis. We will design biotherapies to attenuate the detrimental dysbiotic effects on host health, focusing on gut QS in IBD. The microbiota imbalance observed in IBD leads to high inflammation, expansion of pathobionts, and loss of protection against infections. In previous work, we have shown that by committing the gut microbiota to inter-species QS we could increase members of the microbiota affected by antibiotics, highlighting the potential of QS manipulation to counteract dysbiosis. We propose to manipulate QS of native gut microbes to counteract IBD-associated dysbiosis, and thus inflammation and loss of protection associated with it, rescuing normal microbiota functions. We will tackle dysbiosis by manipulating QS signalling and by fostering specific beneficial interactions amongst microbes. The potential of this therapy, as an alternative or complement to antibiotics, is centred on bypassing the worsening of dysbiosis, like loss of protection against the expansion of inflammation-driving pathobionts and infections, as well as the attenuation of inflammation.
A FLEXIBLE ROUTER FOR LIQUID TUBES AND ELECTRICAL RIBBON CABLES

An improved energy tube-cable-router for securing flat cables and fluid carrying tubes and adapted to eliminate an undesirable pumping action of the fluid within the tubes by maintaining the longitudinal axis of tubes in a plane containing the central radius of curvature of tube-cable-router.
Ultra-morphology of root surface subsequent to periodontal instrumentation: A scanning electron microscope study

Background: The aim of this study was to compare root surface characteristic following root planing with various hand and power driven instruments. Materials and Methods: A total of 20 single rooted teeth were used in this study, of which two specimens were used as control (no instrumentation done) and remaining 18 specimens were equally divided into three groups. Specimens from each group were then subjected to root planing by one of the following instruments: (1) a Gracey curette (2) Ultrasonic tip and (3) a Rotary bur. In each case, the time required for scaling and root planing was measured. After treatment, the specimens were observed under scanning electron microscope and surface roughness was measured by using Roughness and loss of tooth substance index (RLTSI). Results: The mean RLTSI scores for Gracey curette, ultrasonic and rotary instrument group were 2.5, 2.0 and 0.667 respectively. The mean scores of time spent for scaling and root planing by Gracey curette, ultrasonic and rotary instrument group in seconds were 42.50, 35.83 and 54.50. Conclusion: All the three instruments namely Gracey curette, Ultrasonic tip and Rotary bur were effective in mechanical debridement of root surface. The results favoured the use of rotary instruments for root planing to achieve smooth clean root surface; however, the use of rotary instrument was more time consuming which might limit its use in clinical practice.
Preparation of poly(aryl ether ketone ketone)–silica composite aerogel for thermal insulation application

In this study, poly(aryl ether ketone ketone) (PEKK) with trimethoxysilane pendant groups was prepared first and then chemically cross-linked PEKK–silica composite wet gel was formed through the hydrolysis and condensation reactions of the trimethoxysilane pendant groups at room temperature. 29Si solid-state nuclear magnetic resonance indicated that 70.5 % of the methoxy groups on silicon participated in the condensation reaction. The formed PEKK–silica composite wet gel was dried by freeze-drying from tert-butanol to obtain PEKK–silica composite aerogel, which consisted of polymer fibers tangled together. By adjusting the concentration of PEKK with trimethoxysilane pendant groups in solution, PEKK–silica composite aerogels with different densities (ranging from 0.17 to 0.40 g/cm3) were obtained. The resulting aerogels had small average pore diameters (ranging from 25.0 to 59.4 nm), high surface areas (ranging from 299 to 354 m2/g), low thermal conductivities (ranging from 0.024 to 0.035 W/m K at room temperature) and good mechanical property. Although PEKK lost crystallization ability after incorporating trimethoxysilane pendant groups, the cross-linked PEKK still had a storage modulus as high as 1026 MPa at 300 °C. So, even after being heated at 250 °C for 30 min in air, the pore structure of PEKK–silica composite aerogel was still intact.
Trajectory prediction in cluttered voxel environments

Trajectory planning and optimization is a fundamental problem in articulated robotics. It is often viewed as a two phase problem of initial feasible path planning around obstacles and subsequent optimization of a trajectory satisfying dynamical constraints. There are many methods that can generate good movements when given enough time, but planning for high-dimensional robot configuration spaces in realistic environments with many objects in real time remains challenging. This work presents a novel way for faster movement planning in such environments by predicting good path initializations. We build on our previous work on trajectory prediction by adapting it to environments modeled with voxel grids and defining a frame invariant prototype trajectory space. The constructed representations can generalize to a wide range of situations, allowing to predict good movement trajectories and speed up convergence of robot motion planning. An empirical comparison of the effect on planning movements with a combination of different trajectory initializations and local planners is presented and tested on a Schunk arm manipulation platform with laser sensors in simulation and hardware.
A Comparison of the Diagnostic Yield of Rigid and Semirigid Thoracoscopes

Medical thoracoscopy has an important place in the diagnosis and management of pleural disease. However, the application of this procedure is limited in the United Kingdom. This may be partly because respiratory physicians remain unfamiliar with standard rigid thoracoscopy instruments. However, the semirigid variant, popular in Europe and Japan, is similar in design to the commonly used flexible bronchoscope. The larger biopsy size obtained with the conventional rigid thoracoscope has been quoted as a reason for its superiority. To compare the histologic yield of the 2 instruments, the current authors studied a series of 66 patients with unilateral exudative pleural effusions. Twenty-seven rigid and 39 semirigid thoracoscopy procedures were included. Thoracoscopic pleural biopsy achieved a positive diagnosis in 26 of 27 patients in the rigid thoracoscopy group (96.3%) and 36 of 39 patients in the semirigid group (92.3%). Statistically, this difference was not significant (95% confidence intervals, -0.11 to 0.17). Our study demonstrates that the semirigid thoracoscope achieves a diagnostic yield similar to that of the conventional rigid instrument despite the smaller biopsy size. Both instruments remain valuable in the evaluation and management of pleural disease.