SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
On time emergency response system

For Emergency Medical Services (EMS), late arrivals and long response times constitute losses in lives and higher hospitalization costs. 5 mins is the best response time to save more lives and 12 mins is the maximum threshold EMS estimate for an ambulance to be helpful. These times, however, are hard to meet (>50% emergencies do not even meet the latter). In EMS dispatch centers, operators must assess emergencies in real time, based on their best effort to decide which vehicle arrangement is the most adequate for each scenario. Speed is critical, so pre-positioning vehicles is the key to meet the required response time. The high complexity of the system produces uncertain demand and supply (incidents and vehicle availability), which gets worse due to traffic, incident severity, multiple/simultaneous incidents, and different types/sizes of ambulances and associated equipment. 
SECONDS is an innovative, real-time vehicle management system for emergency dispatchers, maximizing coverage and reducing response time. It provides +35% ambulance arrivals below 12-min threshold time; it is able to manage simultaneous incidents in the same area; it forecasts locations with a higher emergency probability and provides predictive incident location, which means 25% less vehicle driving mileage, higher vehicle availability; faster patient delivery to hospital; less pollution. For EMS dispatch center operators, it will provide 2.5 faster response time, asset (vehicle + medical staff) usability management, reduced cost and crew overtime, as well as better decisions – less pressure on operators – and better monitoring. For citizens/persons in need, it will bring a higher survival rate (up to 14% mortality reduction) and richer experience – better care. SECONDS will bring our company international expansion, valuable IP assets, €24.6M profits over 5 years via subscriptions/consulting, a ROI of 844% and the creation of 59 additional qualified jobs.
Advanced Service of Crisis and Emergencies Laboratory in the harbours of the cooperation space of the upper Tyrrhenian, based on Simulation

This joint project focuses on emergency management of the Italian and French coastal marine areas earmarked for critical infrastructure. Considering the territorial contiguity and type of operation required, initiatives supporting more standardised actions should provide maximum benefit. This project’s objective is to set up a permanent laboratory to identify, test and validate integrated emergency management procedures in the event of accidents, crises or significant accidents occurring during the loading and unloading of goods and dangerous substances in port areas. These actions will help identify standard organisation and behaviour protocols to better assist operator skills in emergencies. Indeed, one of the weakest and most critical phases of the logistic chain for this type of goods is determined by physical discontinuity in passing from sea to land (and vice versa). It will investigate the behaviour of emergency operators and test new behavioural protocols, operating standards, emergency monitoring and control procedures and support technologies for infrastructure and on-board systems. It will introduce the concept of Extended Maritime Framework and MS2G (Modelling, Interoperable Simulation and Serious Games) simulation techniques to combine different models and guarantee a high level of fidelity and simplicity of use. The ALACRES 2 simulation will reproduce two specific types of accident (i.e. tank explosion, accident during loading/unloading operations) in the different regional areas involved in improving maritime safety.
Former Bush adviser is appointed to lead Global Fund

The Global Fund to Fight Aids, Tuberculosis, and Malaria has appointed Mark Dybul as its executive director.

Dybul, a medical doctor and former head of the US President’s Emergency Plan for AIDS Relief (PEPFAR), had already emerged as a frontrunner in a shortlist of four candidates and was formally appointed on 15 November.

In recent years the Global Fund has had its reputation damaged, notably by fraud, but it is hoped that the appointment will be a key step in its rehabilitation.1

Dybul rose to prominence for his role in helping to create and then lead PEPFAR. When it was set up in 2003 by the former president George W …
Social innovation modelling approaches to realizing transition to energy efficiency and sustainability

Understanding citizen acceptance of the Energy Union, responsiveness to socioeconomic incentives for increased ownership, and prosumerism requires a multidisciplinary understanding of social systems and inclusiveness and robustness of policymaking depends on having empirically and theoretically grounded methodological tools to assess and adapt policy strategies. SMARTEES addresses this need by an iterative process: (1) integration of theories and methodologies of social innovation and agent-based socio-economic simulation in a comprehensive, flexible framework; (2) unprecedented data collection and integration in five trans-European case clusters in the domains of consumer-driven regenerative energy production, energy efficiency in buildings, low-carbon regional transport and consumer empowerment; (3) dynamic, multilevel agent-based models of successful innovation transfer; which ultimately lead to (4) a policy sandbox which allows a realistic prospective analysis of existing and future policy and market incentive scenarios. Each case cluster addresses a particular social innovation and consists of two reference cases and 4-5 followers. This enables SMARTEES to study the upscaling and replicability in different contexts. The policy sandbox is developed in a co-constructive process with users on the case level and in policymakers workshops on the European level. By doing this, SMARTEES contributes to robust and adaptive future policymaking, understanding of barriers and sources of resistance, the effects of the Energy Union on vulnerable consumer groups, genders and cultures. Furthermore, SMARTEES substantially drives advancement of social innovation and social simulation research by dynamic modelling of supply chains, companies, social groups, cities and neighbourhoods. In addition to making all modelling code and findings publically available, SMARTEES also ensures long term impact of the project by developing a commercialized version of the policy sandbox tool.
Molecular markers in bladder cancer: Novel research frontiers

Bladder cancer (BC) is a heterogeneous disease encompassing distinct biologic features that lead to extremely different clinical behaviors. In the last 20 years, great efforts have been made to predict disease outcome and response to treatment by developing risk assessment calculators based on multiple standard clinical-pathological factors, as well as by testing several molecular markers. Unfortunately, risk assessment calculators alone fail to accurately assess a single patient's prognosis and response to different treatment options. Several molecular markers easily assessable by routine immunohistochemical techniques hold promise for becoming widely available and cost-effective tools for a more reliable risk assessment, but none have yet entered routine clinical practice. Current research is therefore moving towards (i) identifying novel molecular markers; (ii) testing old and new markers in homogeneous patients' populations receiving homogeneous treatments; (iii) generating a multimarker panel that could be easily, and thus routinely, used in clinical practice; (iv) developing novel risk assessment tools, possibly combining standard clinical-pathological factors with molecular markers. This review analyses the emerging body of literature concerning novel biomarkers, ranging from genetic changes to altered expression of a huge variety of molecules, potentially involved in BC outcome and response to treatment. Findings suggest that some of these indicators, such as serum circulating tumor cells and tissue mitochondrial DNA, seem to be easily assessable and provide reliable information. Other markers, such as the phosphoinositide-3-kinase (PI3K)/AKT (serine-threonine kinase)/mTOR (mammalian target of rapamycin) pathway and epigenetic changes in DNA methylation seem to not only have prognostic/predictive value but also, most importantly, represent valuable therapeutic targets. Finally, there is increasing evidence that the development of novel risk assessment tools combining standard clinical-pathological factors with molecular markers represents a major quest in managing this poorly predictable disease.
Road traffic crashes and prescribed methadone and buprenorphine: A french registry-based case–control study

Opioids have been shown to impair psychomotor and cognitive functioning in healthy volunteers with no history of opioid abuse. Few or no significant effects have been found in opioid-dependant patients in experimental or driving simulation studies. The risk of road traffic crash among patients under buprenorphine or methadone has not been subject to epidemiological investigation so far. The objective was to investigate the association between the risk of being responsible for a road traffic crash and the use of buprenorphine and methadone.Data from three French national databases were extracted and matched: the national health care insurance database, police reports, and the national police database of injurious crashes. Case-control analysis comparing responsible versus non responsible drivers was conducted.72,685 drivers involved in an injurious crash in France over the July 2005-May 2008 period, were identified by their national health care number. The 196 drivers exposed to buprenorphine or methadone on the day of crash were young, essentially males, with an important co-consumption of other substances (alcohol and benzodiazepines). Injured drivers exposed to buprenorphine or methadone on the day of crash, had an increased risk of being responsible for the crash (odds ratio (OR)=2.02, 95% confidence interval (CI): 1.40 and 2.91).Users of methadone and buprenorphine were at increased risk of being responsible for injurious road traffic crashes. The increased risk could be explained by the combined effect of risky behaviors and treatments.
Rapid tree-planting through the use of remote sensing and unmanned vehicle planting technologies for large scale reforestation

Currently used methods for reforestation and tree-planting such as hand planting and direct seeding  are time-consuming and expensive. As a result tree-planting has been unable to keep up with number of trees lost each year. Right now we are facing a net global loss of 6.6 billion trees each year. 
The EU is currently seeking out solutions to facilitate the sustainable supply of materials for the future and BioCarbon Engineering have developed a planting system to enable industrial scale reforestation protecting and regenerating forest resources. The planting system developed by BioCarbon Engineering consists of a mapping unmanned aerial vehicle (UAV), a planting UAV and machine learning software. It is a massive improvement on current reforesting techniques being a fully automated process and it will simultaneously enable cheaper and faster tree planting (10 seeds planted per UAV per minute). Given that the planting is being carried out by an aerial vehicle, it is possible to plant in terrain that is inaccessible by land-based approaches. It therefore offers a higher return on investment since it can carry out the same activity at a lower cost while also having a greater reach for tree planting.
The Phase 1 project will be focused on establishing a complete supply chain, a sound business model and commercialization strategy, a planning of all activities for deploying a large scale pilot with the automated planting solution being demonstrated out in different ecosystems throughout Europe, as well as the elaboration of an industrialization and marketing plan.
Three-dimensional Kinematic Mechanism Research on Women's Shot Put Technique of Medalist in the Jinan National Games

The method of close-range machine three-dimensional camera and three-dimensional kinematics is adopted to analyze the technique of top 3 shot putters in Jinan National Games.The result shows that in the slide stage,the highest speed of LI ling swinging leg appear in the right pedal from the earth moments,left leg swinging way is not reasonable.The moment of LI Ling and LI Mei-ju right foot hit the ground body center of gravity velocity and shot put velocity are more differ and affect outstrip apparatus operative effect.The three athletes' right coxa velocity are greater than left coxa velocity in transition period which is advantageous to coxa axis of abscissae's making longer to be available of the outstripping of shoulder axis of abscissae and the body muscles.The three athletes' right coxa,right shoulder,right elbow and velocity of 4 links are gradually increased,and this is the performance of high horizontal technique character of athlete.Three athletes' left supporting pedal techniques is not very ideal,the moment of shot exists different degree of hip flexion bending phenomenon,which impact the force effect.
Towards an improved understanding of the mechanical properties and rheology of the lithosphere: an introductory article to ‘Rock Deformation from Field, Experiments and Theory: A Volume in Honour of Ernie Rutter’

Ernie Rutter’s influential contribution to our understanding of rock deformation spans the whole continental crust, from deformation ‘just under the grass’ (e.g. Rutter & Green 2011) to melt migration in the lower crust (e.g. Rutter & Neumann 1995). Ernie has also worked on many aspects of the deformation of oceanic crust (Rutter & Brodie 1988); however, here we reflect on the wide range of deformation conditions Ernie has studied by presenting key aspects of the strength and rheology of the continental lithosphere as we understand it today, with the aim of providing the context for the contributions included within this volume. The continental crust forms just over a third of the Earth’s surface and it is different from the crust of any other planet in our solar system. It is rich in those elements that partition in a silicate melt and its formation and evolution determined the composition of the mantle and that of the atmosphere (Hawkesworth 2006). Thanks to its physical and chemical fingerprint, the Earth’s crust has sustained life uninterrupted for 3.8 Ga and it is the source of major natural resources such as hydrocarbons and mineral deposits and others such as geothermal energy. The continental crust is less dense than its oceanic counterpart, and is therefore more buoyant. It forms a substantial part of the cold thermal layer of the Earth and its rheology (from Greek r1v rheō, ‘flow’ and -logia, -logia, ‘study’; ‘the study of the flow of matter’) is a key factor controlling plate tectonic processes at the Earth’s surface and in its interior (Davies 2011). Beneath the continental crust lies the lithospheric mantle and together they form the continental lithosphere. Considerable variations in structure, thickness and composition of the continental lithosphere mean that, despite its importance, we currently have limited understanding of the rheology of this complex system (Thatcher & Pollitz 2008). Significant advances in our knowledge of continental rheology have been possible through:
Effects of imperatorin on nicotine-induced anxiety- and memory-related responses and oxidative stress in mice

The purpose of the reported experiments was to examine the effects of imperatorin [9-[(3-methylbut-2-en-1-yl)oxy]-7H-furo[3,2-g]chromen-7-one] on anxiety and memory-related responses induced by nicotine in mice and their relation to the level of nicotine-induced oxidative stress in brain as well as in the hippocampus and the prefrontal cortex. Male Swiss mice were tested for anxiety in the elevated plus maze test (EPM), and for cognition using passive avoidance (PA) procedures. Imperatorin, purified by high-speed counter-current chromatography from methanol extract of fruits of Angelica officinalis, acutely administered at the doses of 10 and 20mg/kg impaired the anxiogenic effect of nicotine (0.1mg/kg, s.c.). Furthermore, acute injections of subthreshold dose of imperatorin (1mg/kg, i.p.) improved processes of memory acquisition when co-administered with nicotine used at non-active dose of 0.05 mg/kg, s.c. Additionally, repeated administration of imperatorin (1mg/kg, i.p., twice daily, for 6 days) improved different stages of memory processes (both acquisition and consolidation) when injected in combination with non-active dose of nicotine (0.05 mg/kg, s.c.) in the PA task. Oxidative stress was assessed by determination of antioxidant enzymes (glutathione peroxidases (GPx), superoxide dismutase (SOD), glutathione reductase (GR)) activities as well as of malondialdehyde (MDA) concentration in the whole brain, the hippocampus and the prefrontal cortex after repeated administration of imperatorin (1mg/kg, 6 days) and single nicotine injection (0.05 mg/kgs.c.) on the seventh day. The results of our research suggest strong behavioural interaction between imperatorin and nicotine at the level of anxiety- and cognitive-like processes. Furthermore, imperatorin inhibited nicotine-induced changes in examined indicators of oxidative stress, especially in the hippocampus and the cortex.
Responsabilidade ambiental do setor bancário: incorporação do risco ambiental no processo de crédito

A atividade das instituições financeiras é cercada de riscos. Entre eles estão o risco de mercado, de crédito, operacional, legal e de imagem. A esses junta-se o risco ambiental, que passou a ganhar notoriedade a partir de batalhas judiciais que culminaram na condenação de bancos nos EUA por danos ambientais causados por tomadores de crédito. No Brasil, com o intuito de regular as instituições financeiras acerca do tema, o Banco Central do Brasil (BCB) divulgou a Resolução nº 4.327/2014 (BCB, 2014), que passou a exigir das instituições financeiras a elaboração de Política de Responsabilidade Socioambiental – PRSA. Este artigo investiga a incorporação dos riscos ambientais no processo de crédito de instituições bancárias brasileiras. Para tanto, conduziu-se pesquisa qualitativa nos Relatórios de Sustentabilidade de 2016 e 2017 dos cinco maiores bancos de mercado no país. Buscaram-se os termos “risco ambiental”, “riscos ambientais”, “risco socioambiental” e “riscos socioambientais” aplicados ao processo de crédito. Os resultados dessas buscas foram enquadrados em onze categorias previamente estipuladas com o intuito de homogeneizar os achados e facilitar a sua observação. Tais categorias foram elaboradas com base nas exigências e recomendações das principais leis e normativos sobre o tema em vigor no Brasil. A pesquisa indicou que os riscos socioambientais são absorvidos de forma seletiva ao processo de crédito. Ela é norteada pelo cumprimento das obrigações legais, pela probabilidade de ocorrência de eventos que possam provocar prejuízos financeiros e pelos valores envolvidos. Assim, o foco é nos financiamentos de grandes projetos, especialmente aqueles abrangidos pelos Princípios do Equador. Quanto às operações de crédito de menor valor, observou-se que, de maneira geral, os bancos expõem-se aos riscos socioambientais, ainda que de maneira pulverizada. A exceção ocorre para crédito destinado a certas atividades, como a rural, por serem consideradas potencialmente impactantes e alguns tipos específicos de linhas como o financiamento de imóveis.
A NON-DESENSITIZING MUTANT OF THE TRANSIENT RECEPTOR POTENTIAL TRPMS ION CHANNEL

There exists a need in the art for high throughput screening assays that can identify compounds that specifically modulate the activity of fast-acting ion channels, such as TRPM5. Current methods, especially electrophysiological, suffer from a lack of sensitivity, rapid signal loss, low throughput, and are labor intensive. The claimed methods and compositions provide electrophysiology methods that allow prolonged sample testing and fluorescent assays with an optical readout that gives rapid readout of the results, has a high signal to noise background ratio, are easy to use, can be modified for automation and miniaturization, and provide verification that a compound specifically modulates TRPM5.
Bryophytes from Martírios-Andorinhas Mountain Ridge, a Highly Impacted Amazonia-Cerrado Transition Zone in Southeastern Pará, Brazil

Bryophytes de la crête de la montagne Martírios-Andorinhas, une zone de transition Amazonie-Cerrado fortement impactée dans le sud-est du Pará, Brésil. La crête de la montagne Martírios-Andorinhas, dans le sud-est du Pará, est située dans une zone de transition entre deux biomes importants d'Amérique tropicale: l'Amazonie et le Cerrado brésilien. Le but de cette étude était d'étudier la flore des bryophytes dans différentes formations végétales de la crête de Martírios-Andorinhas, afin de contribuer à l'évaluation de l'état de conservation environnementale de la zone. Un total de 1784 spécimens (1093 de mousses, 691 d'hépatiques) ont été collectés, avec une prévalence des mousses sur les hépatiques. En terme de richesse spécifique, cependant, les hépatiques (65 spp.) étaient aussi diverses que les mousses (65). Le nombre de spécimens était plus élevé dans la forêt secondaire (799), suivie de la forêt galerie (670), de la forêt riveraine (208) et de la savane (107). À son tour, en nombre d'espèces, la forêt galerie (88 spp./25 exclusives) a dépassé la forêt secondaire (75/17), la forêt riveraine (64/8) et la savane (32/1). La composition et la richesse des bryophytes reflètent les conditions environnementales de chaque type de végétation. Six espèces sont de nouvelles occurrences pour l'état du Pará, quatre pour la région du nord et une pour le Brésil. La grande majorité (95 %) des espèces étaient déjà répertoriées dans le domaine amazonien, tandis que 76 % étaient connues dans le domaine du Cerrado. Le pourcentage élevé d'espèces enregistrées en Amazonie peut s'expliquer par la présence de forêts humides de plaine dans la zone d'étude, favorisant l'établissement d'espèces amazoniennes dont de nombreuses Lejeuneaceae.
The max quasi-independent set problem

In this paper, we deal with the problem of finding quasi-independent sets in graphs. This problem is formally defined in three versions, which are shown to be polynomially equivalent. The one that looks most general, namely, f-max quasi-independent set, consists of, given a graph and a non-decreasing function f, finding a maximum size subset Q of the vertices of the graph, such that the number of edges in the induced subgraph is less than or equal to f(|Q|). For this problem, we show an exact solution method that runs within time $O^{*}(2^{\frac{d-27/23}{d+1}n})$ on graphs of average degree bounded by d. For the most specifically defined ?-max quasi-independent set and k-max quasi-independent set problems, several results on complexity and approximation are shown, and greedy algorithms are proposed, analyzed and tested.