SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Baeyer villiger monooxygenases as biocatalytic parts for monomers of new lactone-based polymeric materials

Recent advances in the development of both experimental and computational protein engineering tools have enabled a number of further successes in the development of biocatalysts ready for large-scale applications.The production of monomers from cheap, readily available components (e.g. terpenoids) for sustainable biopolymer synthesis is a growing area of interest. Biomaterials composed of lactone monomers have been used to produce polyurethanes.The present research proposal is focused on the deep understanding of catalysis by newly identified BVMO enzymes, realized through detailed structural and functional analysis of enzyme mechanisms and substrate/coenzyme recognition. This project will involve multidisciplinary training, with clear objectives in the technical areas of synthetic biology, proteomics, structural biology and biophysical chemistry. This project will allow me to work on structure/function relationship of proteins and to extend my knowledge in metabolic pathway engineering especially in understanding of monooxygenases.The objective will be to identify new Baeyer Villiger monooxygenases biocatalysts that have the appropriate biocatalytic and stability characteristics to enable lactone monomer synthesis. The methods would generate novel structural and biocatalytic data to provide a comprehensive toolkit of flavin-dependent BayerVilliger monooxygenases that are suitable for exploitation in lactone monomer synthesis. These new biocatalysts will be used to construct new strains of E. coli that are capable of producing the target lactone monomers in high yield. The immediate outcomes will be new structural information (native and variant forms of the enzymes); new biocatalytic parameters (reactivity profiles with target substrates; stereoselectivity; conversion; stability; coenzyme specificities) and new lactone producing strains generated from existing monoterpene producing E. coli strains.
Design and analysis of full-state feedback controller for a tractor active suspension: implications for crop yield.

Vehicle suspension systems are needed in modern tractors to improve ride comfort by insulating driver’s cabin from road disturbances. Active suspension (AS) systems have the potential to improve both ride quality and handling vibration performance upon use of feedback to control its hydraulic actuator. This gives a capability to the vehicle to continuously adjust itself and response to the varying road conditions. The main objective of this study was to use a full-state feedback approach to design and analysis of AS control system for Kubota M110X tractor to eliminate the transmitted vibrations to the driver’s cabin caused by field roughness. The inputs of the system were determined as the control force generated from the hydraulic actuator of the AS and the road disturbances caused by holes and uneven surface. A simulation model was developed to analyze the behavior of the system to disturbances with 0.25 m amplitude. Results are included to show the dynamic performance and robustness of the proposed controller in dissipating the corresponding disturbance vibrations for a comfort ride with an instant overshoot of about 12% of the inputs disturbance and a settling time (ST) of 4.36 sec.
Lambda Perturbations of Keplerian Orbits in the Expanding Universe

To estimate the influence of “dark energy” on Keplerian orbits, we solve the general-relativistic equations of motion of a test particle in the field of a pointlike mass embedded in the cosmological background formed by the cosmological constant with realistic cosmological Robertson–Walker asymptotics at infinity. It is found that under certain relations between three crucial parameters of the problem—the initial radius of the orbit, the Schwarzschild and de Sitter radii—a specific secular perturbation caused by $$\Lambda$$
 -term becomes significant, i.e., can reach the rate of the standard Hubble flow. This fact is interesting both by itself and may have important consequences for the long-term dynamics of planets and stellar binary systems.
Probing new physics with coherent elastic neutrino-nucleus  scattering and a tabletop experiment

Ever since the Higgs boson was discovered at the LHC in 2012, we had the confirmation that the Standard Model (SM) of particle physics has to be extended. In parallel, the long lasting Dark Matter (DM) problem, supported by a wealth of evidence ranging from precision cosmology to local astrophysical observations, has been suggesting that new particles should exist. Unfortunately, neither the LHC nor the DM dedicated experiments have significantly detected any exotic signals pointing toward a particular new physics extension of the SM so far.

With this proposal, I want to take a new path in the quest of new physics searches by providing the first high-precision measurement of the neutral current Coherent Elastic Neutrino-Nucleus Scattering (CENNS). By focusing on the sub-100 eV CENNS induced nuclear recoils, my goal is to reach unprecedented sensitivities to various exotic physics scenarios with major implications from cosmology to particle physics, beyond the reach of existing particle physics experiments. These include for instance the existence of sterile neutrinos and of new mediators, that could be related to the DM problem, and the possibility of Non Standard Interactions that would have tremendous implications on the global neutrino physics program. 

To this end, I propose to build a kg-scale cryogenic tabletop neutrino experiment with outstanding sensitivity to low-energy nuclear recoils, called CryoCube, that will be deployed at an optimal nuclear reactor site. The key feature of this proposed detector technology is to combine two target materials: Ge-semiconductor and Zn-superconducting metal. I want to push these two detector techniques beyond the state-of-the-art performance to reach sub-100 eV energy thresholds with unparalleled background rejection capabilities. 

As my proposed CryoCube detector will reach a 5-sigma level CENNS detection significance in a single day, it will be uniquely positioned to probe new physics extensions beyond the SM.
Elucidating therapeutic effects and mode of action of future trophic factorsin als and parkinson’s disease

The prevalence of neurodegenerative diseases such as Parkinson’s disease (PD) and amyotrophic lateral sclerosis (ALS) is growing rapidly due to an aging population and increased life expectancy. Current treatments for ALS and PD only relieve symptoms and cannot stop the progression of the disease, thus there is an urgent need for new therapies. Neurotrophic factors (NTFs) are secretary proteins that regulate the survival of neurons, neurite growth and branching. They have been explored as novel drugs for the treatment of ALS and PD but their efficacy in clinical trials is poor. CDNF is a protein with NTF properties that protects and restores the function of dopamine neurons in rodent and rhesus monkey toxin models of PD more effectively than other NTFs. CDNF is currently in phase 1/2 clinical trials on PD patients. Despite promising results with CDNF in animal models of PD, NTF and CDNF-based treatments have drawbacks. CDNF requires direct delivery to the brain through invasive surgery since, it cannot pass through the blood brain barrier (BBB).  My recent discovery, however, may overcome this difficulty: I showed that a novel CDNF variant protects DA neurons in vitro and in vivo and that it efficiently enters DA neurons in culture. Furthermore, my data show the CDNF fragment can pass through the BBB as measured by 3 different methods and has a neurorestorative effect in a 6-OHDA toxin model of PD when administered subcutaneously. The ultimate goal of my research is to understand the mode of action and therapeutic effect of novel BBB penetrating CDNF-derived polypeptides in cultures of human induced pluripotent stem (iPS) cell-derived nerve cells from patients and in animal models of ALS and PD. The innovative aspect of this proposal is the new groundbreaking concept for treating neurodegenerative diseases – peripheral delivery of BBB penetrating peptides with trophic factor properties and the potential to treat non-motor and motor symptoms in ALS and PD patients.
An innovative solution to tackle food waste through the collaborative power of ict networks

Food waste has received global attention as a major sustainability challenge, with significant implications for the economy, society and the environment. At the same time, it represents a global paradox: whilst a large amount of the food produced each year is wasted, there are huge numbers of people suffering from hunger. 
SavingFood offers a novel approach to tackle food waste by turning this environmental issue into an innovative solution to fight hunger. The project builds on the collaborative power of ICT networks and creates an online community of citizens, food waste stakeholders and policy makers that through knowledge creation and sharing they are empowered to take direct action and become part of the suggested food waste solution.
Through the use of advanced open source tools connected to a social networking environment SavingFood facilitates the redistribution of surplus food to those in need, ensures that no food is wasted through lack of communication, supports the participation of people in organised as well as ad hoc events around food saving and encourages wide debate.
Leveraging on the collaborative power of social networks and by activating the collective intelligence of citizens SavingFood seeks to create a social movement for tackling food waste and influence lifestyles towards a more sustainable future.
ELECTROSPUN PTFE COATED STENT AND METHOD OF USE

A stent or other prosthesis may be formed by coating a single continuous wire scaffold with a polymer coating. The polymer coating may consist of layers of electrospun polytetrafluoroethylene (PTFE). Electrospun PTFE of certain porosities may permit endothelial cell growth within the prosthesis. The stent may be applicable to stents designed for the central venous system, peripheral vascular stents, abdominal aortic aneurism stents, bronchial stents, esophageal stents, biliary stents, or any other stent.
Personalised risk assessment in febrile illness to optimise real-life management across the european union

The management of febrile patients is one of the most common and important problems facing healthcare providers. Distinction between bacterial infections and trivial viral infection on clinical grounds is unreliable, and as a result innumerable patients worldwide undergo hospitalization, invasive investigation and are treated with antibiotics for presumed bacterial infection when, in fact, they are suffering from self-resolving viral infection. 
We aim to improve diagnosis and management of febrile patients, by application of sophisticated phenotypic, transcriptomic (genomic, proteomic) and bioinformatic approaches to well characterised large-scale, multi-national patient cohorts already recruited with EU funding. We will identify, and validate promising new discriminators of bacterial and viral infection including  transcriptomic and clinical phenotypic markers. The most accurate markers distinguishing bacterial and viral infection will be evaluated in prospective cohorts of patients reflecting the different health care settings across European countries. By linking sophisticated new genomic and proteomic approaches to careful clinical phenotyping, and building on pilot data from our previous studies we will develop a comprehensive management plan for febrile patients which can be rolled out in healthcare systems across Europe.
MIXING UNIT FOR USE IN A MIXING APPARATUS AND A MIXING APPARATUS COMPRISING SUCH A MIXING UNIT

A mixing unit (201) for use in a mixing apparatus for mixing treatment media in liquid or gaseous state with a fiber suspension. The mixing unit is adapted to be arranged in a mixing chamber of the mixing apparatus and comprises at least one rotor (207) and at least one stator (209). Each rotor is adapted to be connected to the drive shaft to rotate with the drive shaft in a direction of rotation (R), and each rotor comprises at least one radially extending rotor arm (208a-f). Each stator is arranged axially adjacent at least one rotor, and each stator comprises at least one radially extending stator arm (210a-g). The at least one stator arm and the at least one rotor arm are mutually configured such that at least a portion of a leading surface of said rotor arm passes a front surface of the stator arm at an angle during rotation of said rotor.
Periodontal regeneration through femtosecond laser action

The PRE-Facto fellowship aims to develop a new regenerative approach which potentially will promote the revival of the periodontium, while a successful outcome may lead also to the prevention of the disease when intervened early. Within my research I am going to develop a new biomaterial (calcium phosphates doped with ions of say, cerium and erbium oxides, fluoride and aluminum (3+) ions) with antibacterial properties which will be densified and bonded on the tooth surface after the irradiation with an ultrafast pulsed laser (femtosecond laser). In order to promote the attachment of the fibroblasts, the biomaterial will be mixed with collagen gel (or chitosan) while the effect of the surface topology will be also tested. For my research training as a bioengineer within which I aim to solve periodontitis as a global problem I will deal with the following Research Training Activities (RTAs); i) Synthesis, characterization and delivery of the biomaterial; ii) Sintering of the materials with femtosecond laser - characterization of the sintered area; iii) Cell culture and histological studies for exploring the regenerative potential of the material; iv) Toxicology tests and potential risks investigation. 
This training is not only beneficial for the fellow’s scientific career development, but also for the host institute (the University of Leeds) and the general public health. The above listed training activities will be supplemented by a number of non-Technical skills for my career development. As a result of this cross-disciplinary project the fellow will be a well-rounded bioengineer researcher who in future will be become qualified for pursuing an academic career at the University of Leeds in the area of advanced drug delivery and photo-dynamic therapy using novel femtosecond lasers. Necessary research training and  supervision at the UoL will be provided by the Engineering supervisor Prof. Animesh Jha (AJ) and the clinical supervisor Prof . Monty Duggal.
FOURTH GRADE ELEMENTARY SCHOOL STUDENTS' UNDERSTANDING LEVELS OF AREA SUBJECT: CASE STUDY

With the help of geometry education, students learn geometric figures, their properties, and how to use the relations between them effectively. Students begin learning area concept in elementary level. They find the areas of the given shapes by using the geometric shapes properties which they learnt before. For this aim, teachers use complementary materials in teaching areas such as isometric papers. The purpose of this study is to determine in what degree and how students understand to find the areas of given shapes, as well as, to determine how students' abstract thinking processes are in area subject. This study is a qualitative case study. In this study, one fourth grade level class (31 students) in a public school in center of Kars city is chosen as a case. One question paper which includes open-ended questions and one semi-structured interview form are administered to students in this classroom. Processes in which students try to find the answer in the question paper are analyzed. In addition, students are subjected to an interview according to solve the questions, so how students perceive and understand the questions are examined. In the data analysis, descriptive statistics is used by means of percentage and frequency tables.
Activated Tea Waste as a Potential Low-Cost Adsorbent for the Removal of p-Nitrophenol from Wastewater

The aim of this work was to determine the potential of activated tea waste (ATW) as a useful adsorbent for the removal of p-nitrophenol (p-NP) from aqueous systems. The study was realized using batch experiments with synthetic wastewater having a p-NP concentration of 1000 mg·L−1. The effects of pH, contact time, and presence of anions were investigated. An increase in the pH to above neutrality resulted in a decrease in the p-NP adsorption capacity. The adsorption process reached equilibrium within 5 h of contact time. The Freundlich, Langmuir, Temkin, Dubunin−Radushkevich, and Redlich−Peterson adsorption models were used for mathematical description of the adsorption equilibrium, and it was found that the experimental data fitted very well to the Langmuir isotherm. Batch adsorption studies, based on the assumption of a pseudo-first-order, pseudo-second-order, or intraparticle diffusion mechanism, showed that the kinetic data followed closely a pseudo-second-order rather than a pseudo-first-order mechani...
Protocols for locking sharable files and methods for carrying out the protocols

Methods for locking a file managed by a file system are provided. One example, a file consistency protocol is associated with an operating system (O/S). The file consistency protocol is configured to maintain file consistency between instances of the file associated with the file system using a set of file consistency protocol bits. The method includes determining whether any instance of the file is open, and if no instance of the file is open, the method further includes setting an exclusive bit of the file, the exclusive bit being one of the set of file consistency protocol bits. The setting of the exclusive bit is configured to lock the file from being accessed as another instance.</PTEXT>
Goals of livestock innovation related activities of scientists and extensionists in Veterinary and Animal Science Universities

The present study was carried out to identify different goals of livestock innovation related activities of four veterinary and animal science universities in North India. Further, the study also made an attempt to know the perceived satisfaction level of the respondents with regards to the activities performed in the universities. The data was collected from scientists and extensionists of four Universities and Institutes in North India through questionnaire and discussion. The study indicated that, majority of the scientists perceived that their university aimed to generate own income and reduce the labour costs and also responded that they were more satisfied with the goal of increasing commodity quality and generate own income compared to other activities. Further, majority of the extension experts perceived that their organization aimed to provide knowledge and information and generate own income, while they also reported that goal of providing knowledge and information and introducing new products or processes was considered more satisfactory than other activities. Although, all the goals of activities were equally important, only few of the activities were highly performed in the universities. Hence, there is a need to analyse the importance of each activities and perform them for suitable impact to the farming community. There is also an urgent need to improve upon the quality of these activities performed in the universities by scientists and extensionists so that farming community can be satisfied accordingly.
User-space emulation framework for heterogeneous SOC design

A user-space emulation framework for heterogeneous system-on-chip (SoC) design is provided. Embodiments described herein propose a portable, Linux-based emulation framework to provide an ecosystem for hardware-software co-design of heterogeneous SoCs (e.g., domain-specific SoCs (DSSoCs)) and enable their rapid evaluation during the pre-silicon design phase. This framework holistically targets three key challenges of heterogeneous SoC design: accelerator integration, resource management, and application development. These challenges are addressed via a flexible and lightweight user-space runtime environment that enables easy integration of new accelerators, scheduling heuristics, and user applications, and the utility of each is illustrated through various case studies. A prototype compilation toolchain is introduced that enables automatic mapping of unlabeled C code to heterogeneous SoC platforms. Taken together, this environment offers a unique ecosystem to rapidly perform functional verification and obtain performance and utilization estimates that help accelerate convergence towards a final heterogeneous SoC design.
Helping my company recover from the COVID-19 pandemic

The project concerns support for working capital of a company in the event of a decline in turnover (sales revenue) caused by the negative effects of the COVID-19 outbreak.
ESPERIENZE DI RETE CULTURALE TRANSFRONTALIERA PER LA VALORIZZAZIONE DEL PATRIMONIO NAPOLEONICO

Corsica, Liguria, Sardinia and Tuscany's coastal provinces hold an important asset not yet fully exploited the Napoleonic and often inaccessible.
 The project intends Bonesprit from this potential cultural wealth to create a common system of routes designed to enhance and improve the knowledge and use of such testimony and to define common management tools.
 Recipients of assistance are local institutions, museums, universities and documentation centers, associations and tour operators of the four cross-border regions of space.
 To achieve the overall objective of the project have been identified the following activities:
 • analysis of the quality and characteristics of asset management;
 • creation and implementation of a common signage, web and multimedia publishing products bilingual;
 • creation of cross-border routes and also routes through the Napoleonic interactive technologies and scenic;
 • awareness of tourism;
 • Napoleonic organization of the week open to the public and tour operators for the dissemination and promotion of cross-border route made​​.