SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Abstract 11284: Modulation of Transforming Growth Factor-{beta} Signaling and Extracellular Matrix in Myxomatous Mitral Valve Degeneration by Angiotensin II Receptor Blocker Losartan

Background: No specific treatment exists for myxomatous degeneration of the mitral valve, the pathological hallmark of mitral valve prolapse, associated with symptomatic mitral regurgitation, heart failure and death. Transforming growth factor (TGF)-β is known to cause mitral valve degeneration and regurgitation in a mouse model of Marfan syndrome. We investigated the role of TGF-β in sporadic myxomatous mitral valve disease in humans. Methods and results: Mitral valve tissue was obtained from patients undergoing mitral valve operation or from organ recipients and donors. We used standard techniques of immunohistochemistry, immunofluorescence, immunoblotting, FACS and quantitative real-time PCR. Tissue culture techniques and isolated valve interstitial cells (VIC) were used for in-vitro analysis. Excess extracellular matrix components in diseased tissue correlated with TGF-β up-regulation and SMAD2/3 phosphorylation in-vivo and in-vitro. Both TGF-β ligand and signaling mediators co-localized primarily to VIC suggesting autocrine/paracrine activation. In cultured valve tissue, exogenous TGF-β induced collagen and elastin production, whereas serologic neutralization of TGF-β inhibited the disease-driven, pro-fibrotic process. In cultured VIC, pharmacological inhibitors of TGF-β receptor 1 kinase and SMAD3 decreased TGF-β-mediated production of extracellular matrix molecules. Similar effects were seen for angiotensin receptor blockers with described TGF-β inhibitory activity, including losartan. Remarkably, patients with severe mitral regurgitation who had received losartan for several weeks pre-operatively had less TGF-β activity in resected mitral valves than those who had not. Conclusions: TGF-β signaling pathway is up-regulated and plays an essential role in myxomatous mitral valve degeneration where VIC remains the central source of TGF-β ligand. Attenuation of TGF-β signaling by losartan positively affects the pathological processes involved. Successful modulation of clinical complications of mitral valve propapse with a clinically established agent would be of great significance and could provide new mechanistic specific means affecting clinical outcomes of myxomatous mitral valve disease.
Portfolio entrepreneurial processes in the context of individual ventures: exploratory findings from high technology industry

Ever since MacMillan's (1986) call to study habitual entrepreneurs, much has been learned about the differences between novice and habitual entrepreneurs as well as the differences between serial and portfolio entrepreneurs. This study attempts to go beyond the traditional analysis of portfolio entrepreneurs based on either firm or entrepreneur level. We try to open the black box of individual ventures launched by portfolio entrepreneurs so as to provide a street-level view of what is really happening at individual ventures. Since what, how, and why entrepreneurs do may vary significantly by individual type of ventures they launch, findings from our study, at the micro level of individual venture, should contribute toward better understanding of portfolio entrepreneurial processes. In view of a very limited amount of past research done at the micro level of individual ventures, however, we rely on in-depth interviews with four successful entrepreneurs from high technology industry in Korea to generate findings and insights.
ULTRASONICALLY ASSISTED WIRE ADDITIVE MANUFACTURING PROCESS AND APPARATUS

Methods, apparatus and systems for additive manufacturing are provided. Such may include an additive manufacturing material supply, and an energy source that heats the additive manufacturing material supply, forming a melt pool; and an ultrasonic-vibrating member positioned at a distance behind the energy source, such that the ultrasonic-vibrating member is configured to contact the melt pool on a trailing side of the energy source and provide ultrasonic acoustic cavitation and streaming effects to the additive manufacturing process.
NEAR INFRARED REFLECTING COMPOSITION AND COVERINGS FOR ARCHITECTURAL OPENINGS INCORPORATING SAME

Disclosed are compositions that can be used in forming products with increased near infrared (IR) reflective capability. A composition can include IR reflective and/or IR transmissive non-white pigments and can be formed with suitable viscosity so as to successfully coat substrates, e.g., yarns, suitable for use in forming coverings for architectural openings, e.g., window coverings. Also disclosed are textile substrates coated with the compositions, including textile substrates coated with compositions that include abrasive, inorganic IR reflective dark pigments.
IMMOBILISED IONIC LIQUIDS

Ionic liquids are immobilised on a functionalised support which carries or contains one component of the ionic liquid, or a precursor to such a component. The ionic liquid may be immobilised via the anion by treating a support with an anion source, e.g. an inorganic halide, before the ionic liquid is applied or formed. Alternatively the ionic liquid may be immobilised by having the cation covalently bound to the support, e.g. through silyl groups, or incorporated in the support by synthesising the support in the presence of a suitable base. The immobilised ionic liquids are of use as catalysts for example for the Friedel-Crafts reaction.
Landscape Preference and Map Readability in Design Evaluation of Topographic Maps with an Orthoimage Background

AbstractOrthoimagery and shaded relief are ways of introducing realism to maps, but each method presents design challenges in achieving consistently readable combinations with overlaid vector symbols and labels. Two studies were conducted to compare the readability of the current United States Geological Survey (USGS) ‘US Topo’ map series with two original designs incorporating orthoimagery and shaded relief. The studies examined reader design ratings after completing tasks that required analytical use of maps with varied map designs, using maps of diverse locations in the USA. The studies indicated that readability varied with map location to a greater degree than with map design, though design influence on ratings was detected in interaction with location. This variation with landscape is discussed from the perspective of recent theory in landscape aesthetics and preferences. Also, it was statistically demonstrated that either of the two new designs had improved readability over the existing US Topo. Th...
Boron-Boron multiple bonding

Multiple bonding between atoms is immensely important to chemistry, biology, physics and their associated industries; multiple bonds are both ubiquitous in everyday products and extremely useful functionalities for effecting chemical transformations. While very common with the elements carbon, nitrogen and oxygen, multiple bonding is in comparison extremely rare with other elements. Multiple bonding between heavier elements of the main group of the periodic table becomes less favourable the heavier the element becomes. However, this does not explain the relative paucity of multiple bonding with boron, which is immediately to carbon's left on the periodic table. In particular, isolable, stable compounds containing multiple bonds between two boron atoms are extremely rare, and until 2007 only a handful of charged examples existed.

A revolution in this field has recently been witnessed with the syntheses of the first neutral compounds with boron-boron double bonds, diborenes, and the first compounds with boron-boron triple bonds, diborynes. The first neutral diborenes were prepared in 2007, however, we have recently developed a number of rational, selective and more general routes to these compounds. The first diboryne compounds were prepared by our group in 2012. The significance of these two families of molecules is not only their unusual multiple bonding but also the extremely high electron density on the boron atoms, an unusual situation for an element that is known for its electron-poor character. This high electron density leads to strong boron-based nucleophilicity and extremely high reduction potentials – both highly novel phenomena.

This proposal aims to: (A) comprehensively explore the syntheses of these unique compounds and the limits thereof, and to (B) exploit the unusual reactivity of these electron-rich boron molecules in synthesis, small-molecule activation and materials science.
INNMORES, A MANSION IN THE WOODS. GUEST HOUSE WITH ALPINE VEGETABLE GARDEN OF EDIBLE HERBS

INNMORES? A PROJECT OF TOURIST RECEPTION AT THE SERVICE OF THE DEVELOPMENT OF THE BALTEO PATH. RECOVERING A RUSTIC MOUNTAIN AND ITS ANCIENT TERRACES, OTHERWISE ABANDONED TO DISFIGURE THE LANDSCAPE, INNMORES WANTS TO OFFER REST AND REFRESHMENT SERVICES FOR THE WALKERS OF OROPA AND THE LOWER STREET? THE CONTEXT OF IT? CURRENTLY LIMITEDLY EQUIPPED. INNMORES? SMALL GUESTHOUSE WITH ALPINE VEGETABLE GARDEN OF EDIBLE HERBS. INNMORES WANTS TO SHORTEN THE DISTANCES BETWEEN VISITORS AND THE TERRITORY WITH THE PROPOSAL OF AUTHENTIC AND DISTINCTIVE EXPERIENCES ABLE TO TELL PLACES, PRODUCTIONS AND LOCAL TRADITIONS. FOR THIS REASON, IN ADDITION TO THE BASIC SERVICES OF GUEST HOUSES AND CATERING, INNMORES OFFERS SPECIAL EVENTS AND COOKING EXPERIENCE WITH THE PRODUCTS THAT TELL THE TERRITORY, TAKING ADVANTAGE OF THE SPACES OF THE ALPINE GARDEN OF EDIBLE HERBS, CREATED TO HELP WALKERS LEARN TO RECOGNISE THE ALIMURGICAL HERBS OF THE WALK AND ITS WOODS.
Decentralised qualifications' verification and management for learner empowerment, education reengineering and public sector transformation

QualiChain targets the creation, piloting and evaluation of a decentralised platform for storing, sharing and verifying education and employment qualifications and focuses on the assessment of the potential of blockchain technology, algorithmic techniques and computational intelligence for disrupting the domain of public education, as well as its interfaces with private education, the labour market, public sector administrative procedures and the wider socio-economic developments. The project focuses more specifically on the assessment of the implications (technical, political, socio-economic, legal and cultural) as well as the impact - in terms of benefits and risks - of the prescribed solution’s utilisation, whose disruptive potential lies both in the exploitation of the innovative features of the aforementioned individual technologies, as well as in their unique combination in a new territory for the provision of a set of baseline services (Awards’/ Qualifications’ Archiving; Awards’/ Qualifications’ Verification; Qualifications’ Portfolio Management) and a number of value-adding services (Career Counselling and Intelligent Profiling and Competency Management including Recruitment; Competencies’ Evaluation and Development; Consulting and Decision Support). The proposed solution will be piloted through four representative scenarios, including: (i) cross-university degree equivalence verification; (ii) smart curriculum design; (iii) staffing the public sector; (iv) providing HR consultancy and competency management services.
Semi-Autonomous border surveillance platform combining next generation unmanned aerial vehicles with ultra-high-resolution multi-sensor surveillance payload

The project will combine for the first time a multi-role lighter-than-air (LTA) unmanned aerial vehicle (UAV) with an ultra-high resolution multi-sensor surveillance payload supporting border surveillance as well as search & rescue applications, and specifically rough terrain detection. The sensor payload will include synthetic aperture radar (SAR), laser detection and ranging (LADAR), shortwave/longwave infrared (SWIR/LWIR) and acoustic cameras for direct target detection, as well as optical and hyperspectral cameras for indirect detection (via vegetation disturbance).
The project will use the ground-based infrastructure of border police units (command & control centres), innovative data models (to identify illegal crossing patterns and preferred routes) and advanced audio/video analytics and storage (to provide additional detection capabilities).
The technology concepts will be validated in the field by 6 border police units (Greece, Bulgaria, Romania, Moldova, Ukraine, Belarus) covering 3 major illegal migration routes into Europe (Eastern Mediterranean, Western Balkan and Eastern Borders Routes), which represent 58% of all illegal border crossings detected and are also the most used for smuggling of drugs, weapons and stolen vehicles.
The combined solution will provide high coverage, resolution and revisit time with a lower cost (4 EUR/kg/hr) than satellites and higher endurance (100 kg payload for 12 hours) than drones. Based on the field trial results, the consortium expects to develop a solution that can be deployed further by European border polices after project completion. The project will also involve the contribution of NGOs working with illegal migration and human right protection issues, as well as regulatory experts dealing with the ethics and privacy requirements of border surveillance solutions
Study on Characteristic of Ethanol Production Using Saccharomyces cerevisiae and Pichia stipitis from Woody Floater Wastes in the Dam

Suspended wood waste was being inflow into the dam and the problem of waste disposal has been occurred. In this study, ethanol production using woody floater wastes was performed to estimate value in use for raw material of renewable energy. To achieve the goal, experiments of acid hydrolysis and ethanol fermentation using dam woody floater as raw materials for bioethanol was carried out. In the results of field survey in the chungju dam, kind of woody floater was mainly Japanese larch (Larix leptolepis) and hybrid poplar (Populus tomentiglandulosa). The results of sugar extraction showed that sugar content was higher in Larix leptolepis than Populus tomentiglandulosa. Extracted sugar from wood waste was effective consumed by yeast(P. Stipitis and S cerevisiae). In the experiment consumption of sugar including glucose, galactose and xylose, the consumption rate of S. cerevisiae is faster than that of P. stipitis. and efficiency for ethanol production is higer in S. cerevisiae than P. stipitis. Also it can be confirmed that resource as ethanol production using wood waste was available.
VNF INSTANTIATION METHOD AND APPARATUS

Embodiments of the present invention relate to a VNF instantiation method and an apparatus. The VNF instantiation method includes: A VNFM receives a VNF instantiation request message sent by an NFVO, and determines a QoS attribute of an external connection of a container object to be used by a VNF; the VNFM sends a container object creation request message to CISM, where the request message carries the QoS attribute of the external connection of the container object; and the CISM receives the container object creation request message, reads a descriptor and/or a configuration file of the container object, creates the corresponding container object, determines a type of a connection channel between the container object and a host node based on the QoS attribute of the external connection of the container object, and establishes a connection channel of the corresponding type. According to the method in embodiments of the present invention, when the VNFM manages a VNF instance, a differentiated performance requirement of a VNF network is transferred to the CISM, to implement dynamic generation or update of a container network and quickly respond to a performance requirement change of the VNF network.
Metropolisation and Polycentric Development in Central Europe: Evidence Based Strategic Options

The European Commission considers the Danube Region as one of the most important areas in Europe and has set up a macro-regional strategy encouraging long term co-operation to tackle a wide range of policy challenges. The capital cities of Vienna, Prague, Budapest, Bratislava and Ljubljana wish to play an active role in this co-operation. These big cities are important drivers of development. The five cities therefore wish to strengthen their position as network of metropolises within the European and global territory. They do not only want to be the driver of development for their direct hinterland but also as a network they want to be a driver of development for the entire Danube Region as global integration zone. In order to detect opportunities for sustainable urban development at macro-regional and city-level the project shall carry out a territorial analysis at both levels.
Separator paper for alkaline battery

A separator paper is provided which simultaneously satisfies the requirements to have a high denseness that can prevent internal shortage due to such as the deposition of the zinc oxide dendrite accompanied by not adding mercury, and a high liquid impregnate properties that can improve heavy discharging properties. Said separator paper comprises a dense layer having a certain degree of denseness, and a liquid impregnate layer having a certain degree of liquid impregnate properties, said dense layer and said liquid impregnate layer being integrally laminated, and said dense layer being made by mixing alkali proof cellulose fibers which is applicable for beating with synthetic fibers such that said alkali proof cellulose fibers be included in the range of 20 to 80 weight % with the beating degree of 500 ml to 0 ml at CSF value, and said liquid impregnate layer being made by mixing alkali proof cellulose fibers with synthetic fibers such that said alkali proof cellulose fibers be included in the range of 20 to 80 weight % with the beating degree of more than 700 ml at CSF value.
Boosting Innovation in Factory Of the future value Chain in the Alps

BIFOCAlps project is tackling a common challenge to many Alpine Space (AS) regions: due to globalisation, many enterprises in manufacturing sector are not as competitive as wished in global markets, resulting in increased levels of unemployment, abandoned facilities and remaining plants that need new products and new processes. On the other hand, AS has a strong R&D sector and specialisation on Industry 4.0 and Factory of the Future (FoF) technologies. _x000D_
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BIFOCAlps main objective is to boost collaboration and synergies among main actors of the AS innovation system for a sustainable, smart and competitive development of the manufacturing value chain towards the FoF. _x000D_
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The main outputs will be _x000D_
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(1) a map of the sector at transnational level, to understand existing and potential good and best practices, technologies and competences along the value chain; _x000D_
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(2) a validated methodology for enhancing FoF long-term sustainability through innovation and knowledge transfer among business, academic and policy actors, and _x000D_
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(3) guidelines of strategic actions for influencing policy agenda based on an impact indicator system, to monitor and allow evaluation of performance in line with harmonisation of S3. _x000D_
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PPs and target groups are relevant stakeholders in the field of Industry 4.0 and FoF, which are involved in the policy-making, in the FoF research field and directly in manufacturing value chain. They will mostly participate to and benefit from project activities and outputs.  The innovative approach integrates a “bifocal” view (considering both up- and down-stream value chain) and the transversal competences of the business, research and policy actors at transnational level. It will allow to gather best case scenarios of the AS and to integrate and implement them in the validated methodology, which will build on previous results and will be transferable at cross-national and cross-sectoral level aiming to connect value chain and boost competitiveness of the whole AS in the long term.
RADIAL PRESS

A radial press is provided, the radial press having a frame structure, a pressing tool, a drive unit, and a press control. The pressing tool comprises a plurality of pressing elements which are disposed uniformly concentrically around a press axis and have pressing surfaces. During the appropriate activation of the drive unit, the pressing elements can be moved synchronously as required towards or away from the press axis. To this end, at least two measured value recorders, which are connected for signal transmission purposes to a comparator associated with the press control, are disposed on the pressing tool at positions spaced apart from one another in the direction of the press axis (A). When the comparative value, generated by the comparator, of the measured values provided by the measured value recorders exceeds a tolerance range stored in the press control, an activation of the signal output unit is triggered.
RESEARCH ON DIFFERENT ACUMULATION CHRACTER OF GAS POOL FOR THE FIRST MEMBER OF SHAXIMIAO FORMATION IN THE DATACHANG AREA OF SOUTH SICHUAN

For the obvious selective accumulation characteristics of shallow low-pressure gas reservoir of Datachang in the south of Sichuan,the use of oil and gas accumulation of secondary migration theory is used to analyze the low-pressure gas reservoir of Shaximiao Formation in this area.The differences in oil and gas accumulation in the layer section are controlled by structures,reservoir properties,migration pathways,blocking conditions,which formed a combination of factors and the matching conditions.The accumulation of oil and gas possesses following characters:① Main channel sand body in the high part of structure connects with boundary faults at depth.② Sand body of main river channel sedimentation pinch out upwards with well developed small faults and fissures under the sand bodies.③ Stacked channel sand bodies lie in the channel of oil and gas migration.It is thought that the formation and accumulation of gas and oil in the first Member of Shaximiao Formation were controlled by structures,physical property of reservoir,migration channel and shelter conditions.
“Eco-efficient technologies in transmission, distribution and consumption of electricity as the basis for market expansion ELZIT Sp. z o.o.”.

The scope of the project includes the construction of a workshop and warehouse building together with the purchase of production and service equipment and an off-road special car with HDS hydraulic crane, which will enable ELZIT Sp. z o.o.: 1. breaking existing barriers 2. widening the range of products and services offered by: a)2 new products b)1 new service c)2 significantly improved services 3.substantial expansion of the markets throughout Poland and expansion to external markets by exporting 2 new products to the German market. This will adjust the Company’s offer to the needs and expectations of customers and changing situation in the industry, which will translate into: increase the number of customers from Poland and Germany, increase the competitive potential on the domestic and international scale.