SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Ocean sentinel

Fisheries are operating worldwide over nation’s Economic Exclusive Zones (EEZ) as well as over international waters. Information on the location of fishing is rarely known, especially in international waters, yet it is critical since in many oceanic sectors non declared and illegal fisheries are affecting negatively ecosystems through over exploitation and by catch of non-target species Knowledge about the distribution of fishing boats is fundamental for the regulation of fishing activities as well for the conservation of the oceans. I propose a New Concept of ocean surveillance based on new bio-logging technologies fitted on large foraging marine predators. The OCEAN SENTINEL  Proof of this Concepts will (1) develop a logger called CENTURION that couple a XGPS platform detecting and locating radar emissions, with a satellite transmission system (Argos) that would send instantaneously the location of vessels to a receiving site, (2) deploy the logger on wide ranging animals used as platforms  and (3) make available immediately the information obtained from the CENTURION logger through a website. The OCEAN SENTINEL programme will generate important social benefits by providing information to a wide range of beneficiaries, from governments or regional authorities managing EEZ and natural resources, regional or national fishing authorities, researchers and non-governmental organisation in conservation. The concept will be tested in the Southern Indian Ocean from Crozet and Kerguelen Islands  where valuable and extensive fisheries operate in EEZs and over oceanic waters. This concept has the potential to be used in other areas where information on fisheries location is needed. The project will also lead to further discoveries on the relationship between seabirds and fisheries as well on the extent of fisheries in zones where surveillance by conventional methods is not possible.
BLOOD DRAWING DEVICE

A device for drawing fluid from a lumen, and particularly blood from a blood vessel, is disclosed. The device may provide indication of the entry of an intravenous cannula into the lumen. The device may include a central body having an outer wall and an inner fluid passage. The device may include a luer-type adapter to permit the attachment of an I.V. infusion set of various lengths ("butterfly needle") and or any luer-type fitting attached to an existing device. The outer wall of the central body may be transparent or translucent to permit the detection of fluid within the inner fluid passage. A front cannula may extend from one end of the central body and a rear cannula may extend from the other end of the central body. Both the front and rear cannulae may communicate with the inner fluid passage. A flexible sleeve may surround at least a tip portion of the rear cannula. A venting member may be provided near a base portion of the rear cannula between the flexible sleeve and the ambient. The venting member may permit the passage of air through it, but be substantially impermeable to liquids, such as blood.
Argonaut: from the synthesis of ganglioside tumour antigens to a platform for cancer active immunotherapy

Immunotherapy is currently revolutionizing cancer therapy by harnessing the power of the innate and adaptive immune system against cancer cells, thus providing a more tumour-selective approach in assistance to traditional treatments. The identification of tumour-associated carbohydrate antigens (TACAs), aberrant types of glycans decorating the surface of tumour cells, has paved the way for the development of new types of cancer vaccines. However, while significant progress has been made in this area of research, TACA-based cancer vaccines have not yet reached the clinic. In this context, ARGONAUT will address some limitations that characterize classical approaches in carbohydrate cancer vaccine development, with the overall aim of establishing a strategy to access novel, more effective, and fully synthetic vaccine candidates. ARGONAUT’s journey aims at the preparation of vaccine candidates based on ganglioside-type TACAs (expressed in melanoma, neuroblastoma, and small cell lung cancer) that are easy to formulate, able to elicit a immune response independent from individual polymorphisms, and with better chances to reach the clinical environment. Employing a synthetic carbohydrate chemistry approach, ARGONAUT explores its application as a tool to contribute to H2020 European efforts in cancer research, while providing excellent training in a multidisciplinary and intersectoral environment through a well-implemented work-plan. From another perspective, ARGONAUT’s impact will also benefit from the transfer of knowledge to the host institution with the establishment of a new research line in active cancer immunotherapy.
Histone deacetylases and epigenetic therapies of hematological malignancies

Histone deacetylase inhibitors (HDACi) represent a novel class of targeted drugs which alter the acetylation status of several cellular proteins. These agents, modulating both chromatin structure through histone acetylation, and the activity of several non-histone substrates, are at the same time able to determine changes in gene transcription and to induce a plethora of biological effects ranging from cell death induction, to differentiation, angiogenesis inhibition or modulation of immune responses. The impressive anticancer activity observed in both in vitro and in vivo cancer models, together with their preferential effect on cancer cells, have led to a huge effort into the identification and development of HDACi with different characteristics. To date, several clinical trials of HDACi conducted in solid tumors and hematological malignancies have shown a preferential clinical efficacy of these drugs in hematological malignancies, and in particular in cutaneous T-cell lymphoma (CTCL), peripheral T-cell lymphoma (PTCL), Hodgkin lymphoma (HL) and myeloid malignancies. Several agents are also beginning to be tested in combination therapies, either as chemo sensitizing agents in association with standard chemotherapy drugs or in combination with DNA methyltransferase inhibitors (DNMTi) in the context of the so-called "epigenetic therapies", aimed to revert epigenetic alterations found in cancer cells. Herein, we will review HDACi data in hematological malignancies questioning the molecular basis of observed clinical responses, and highlighting some of the concerns raised on the use of these drugs for cancer therapy.
Molecular dissection of titin-based mechanisms in charge of cardiomyocyte dysfunction in terminal feart failure

Chronic heart failure is a leading cause of mortality in the industrialized countries. Pathomechanistically, a variety of diverse stress signals on the cardiomyocyte trigger loss of myofibrils and cardiomyocyte death, thereby activating a vicious cycle of cardiac stress and deterioration during terminal heart failure. Despite the enormous clinical relevance, the exact pathomechanisms in charge remains unclear.

Here, I propose to investigate the molecular mechanisms that couple mechanical cardiomyocyte strain and cardiomyocyte loss during the heart failure involving the mechanosensing titin filament. For this, I will perform research in three globally leading teams and access their complementary expertise in a secondment scheme. In the the proposed 2-year outgoing phase, I will study how cardioprotection is mediated by key factors recently identified in the Ju Chen lab (UCSD, San Diego). During this time, I will be trained in cutting-edge molecular mouse genetic models and phenotyping tools. This research is expected to shed light on CARP-titinsignaling axis in cardiomyocyte death and to provide tools for manipulating this pathway. In a one-year re-integration phase I will perform follow-up mechanistic structural studies in the Olga Mayans lab (University of Liverpool) to determine the structural basis how the CARP (cardiac ankyrin repeat protein)-titin signaling axis mediates cardiomyocyte protection, and in the Labeit lab (University of Heidelberg, Medical Faculty Mannheim) how to perturb activity of this complex by small molecules.

Taken together, this work encompasses structural studies at the atomic level up to vivo animal models to study CARP-titin functions. After the propose three years, I expect to be ready to pursue an independent career in the field of molecular cardiology research. Therefore, my goal during the re-integration phase will be to set-up an interdisciplinary collaboration involving the three lead teams of this proposal.
THE ANALYSIS OF VALUE ADDED AS AN INDICATOR OF INTELLECTUAL CAPITAL AND ITS ASSOCIATION TOWARDS COMPANY PERFORMANCE

The principal purpose of this research is to investigate the association between the efficiency of value added (VA) by the major components of a firm’s resources base (physical capital, human capital and structural capital), and also the Value Added Intellectual Coefficient (VAICTM) toward the firm’s economic, financial and stock market performance. Data are drawn from a sample of 324 companies listed in Indonesia Stock Exchange for the year of 2009 which is divided into primary, secondary, and tertiary industry sectors.
The result is obtained by using multiple regression analysis. From the result, it is discovered that physical capital, structural capital and VAICTM have significant associations toward company’s economic, financial and stock market performance, while human capital only has significant association towards firm’s economic performance. The research result also shows that the contribution of intellectual capital differs across industry sectors.
Fabrication of silicon carbide reinforced aluminum matrix nanocomposites and characterization of its mechanical properties using non-destructive technique

Abstract The SiC nanoparticulate reinforced Al matrix composites (with 2.5–12.5 vol%) were successfully fabricated by employing high energy ball milling with cold-pressing and sintering technology at 550 °C for 1 h. Microstructures and nanoparticulate distribution were analyzed with scanning electron microscope (SEM), X-ray diffraction (XRD) and transmission electron microscope (TEM). Mechanical property and hardness were studied using pulse echo overlap (PEO) method as a non-destructive technique. Microstructure analysis showed that the nanocomposites contained only α-Al and SiC phases with clean interface of thickness ∼1.5 nm, and preserved nano-grained network structure. The SiC nanoparticulates were distributed uniformly in a metal matrix, and neither voids nor cracks were detected at the interface of Al/SiC. Besides, there was no reaction product has been found at the interface. Accordingly, the mechanical properties of composites reinforced by SiC nanoparticulates were significantly improved, while the Poisson's ratio of nanocomposites was retained. This was mainly due to the stronger interfacial bonding derived from direct mechanical interlocking between the adjacent component surfaces.
Monument nomination and pilot implementation as an alternative form of architecture and religion tourism

The operation “Mo.No.Pi - Monument Nomination and Pilot Implementation as an Alternative Form of Architecture and Religion Tourism” focuses on the promotion of monasteries as important sites of cultural heritage. Monasteries frequently require significant amounts of resources for restoration and maintenance but, apart from being sanctuaries for contemplation, they can act as growth poles for the development of their surrounding areas. Objectives Based on a close cooperation of representatives of monasteries with governmental organisations, the operation wants to explore opportunities for an active role of monasteries in regional development. More specifically, it promotes the contribution of monasteries to economic development based on the range of possible usage types for religious, educational and/or tourism purposes and aims at developing policy tools to ensure sustainable management. Results The operation enhances public awareness for European religious and secular traditions. It improves available policies and tools to include monasteries into regional development strategies and bridges between traditional usage and modern interests. It thus helps overcome existing barriers and promotes the role of monasteries as enterprises, training facilities and religious centers. Activities include the set up of an interregional co-operation platform for monasteries and the identification of tools suitable for promoting the roles of monasteries in regional development. Partners conduct a range of case studies, elaborate new user concepts, prepare a handbook for the management of monasteries, and conduct a range of training seminars.
Interactions between hearing loss and the spectral overlap of competing sounds in masked speech intelligibility.

This experiment explored the ideas that energetic masking (EM) limits the benefit achievable from spatial separation in a competing speech task and that differences in EM between normal‐hearing (NH) and hearing‐impaired (HI) listeners can explain differences in spatial release from masking (SRM). Target sentences and similar masker sentences (or in another condition, masker noises) were filtered into four narrow spectral bands and presented simultaneously. The spectral overlap of the target and masker bands was varied from minimal (interleaved bands) to maximal (identical bands). Both NH and HI listeners showed spectral tuning, such that masking by noise or speech was reduced as spectral overlap was reduced. In fact, this signal processing often improved intelligibility relative to that seen with unfiltered speech. Moreover, thresholds in the noise and speech maskers were closely related, suggesting that EM was the main factor limiting performance across tasks. More masking was found in HI as compared to ...
Influence Analysis of Cracks of the Sluice Bottom Board

After running for half a year, periodic inspection to a discharge sluice shows that cracks in the direction of water current appear in the bottom board of most of sluice lockage chamber. Stress computation under the design conditions and the working conditions after cracks appeared are carried out with 3D-FEM respectively. The results indicated that the stress of the bottom board is still within the allowed range, the structure is safe from the view of the stress. But considering the defective parts of bottom surface and interlayer surface are likely to be connected with vertical cracks, seepage follow channel will be formed, and it will affect the long-term safe operation of the whole structure, it is suggested that cracks in bottom board should be repaired.
Salt tectonics and dynamics

Many of the world’s oil and gas reservoirs occur in the vicinity of salt structures within sedimentary basins. Because salt is a weak and low-density rock, it flows on geological timescales and forms kilometre-high structures that strongly deform nearby sedimentary layers. This poses several challenges for the industry:
  1) Finding new oil and gas fields requires a geological reconstruction of how the sedimentary basin evolved with time, in order to understand where hydrocarbons formed, how they migrated and where they might be stored now. Existing geological reconstruction methods use simple kinematic rules, which don’t work well in regions that are affected by salt tectonics as salt flows in a 3D manner and over large distances.
  2) Drilling through or nearby salt structures can pose a risk, as they perturb the stresses within the basin, which can cause drill holes to collapse and other costly delays in the drilling process.
To guide and assist oil exploration, we propose a radically different technique that relies on combining advanced computer simulations of the sedimentary basin with available data. Our method is able to reconstruct in a physically consistent manner the geological evolution of the basin, even if it is strongly affected by salt tectonics. It also predicts the 3D stress field of the subsurface together with uncertainty bounds, which will allow companies to design future drilling campaigns to be safer and more efficient. The recent drop in the price of oil has concentrated the industry’s exploration effort on increased-value projects, both by cutting costs for existing exploration methods and by further leveraging already acquired data via new interpretation techniques. We will address both of these industry requirements in areas where salt tectonics are prevalent. Within this proof of concept grant, we will work with industry partners to apply our methods to natural case studies and demonstrate its economic viability and cost-saving potential.
Myopia and Cognitive Dysfunction: The Singapore Malay Eye Study

To investigate a possible relationship between refractive error and cognitive function.This population-based, cross-sectional study included 1032 persons aged 60 to 79 who participated in the Singapore Malay Eye Study. Refraction (sphere, cylinder, and axis) was measured using an autorefractor, and spherical equivalent was defined as sphere plus half negative cylinder. Refractive errors were defined as myopia (spherical equivalent < -0.5), emmetropia (-0.5 diopter [D] ≤ spherical equivalent ≤ 0.5 D), and hyperopia (spherical equivalent > 0.5 D). Visual acuity was measured with a logMAR chart. Cognitive dysfunction, assessed using the Abbreviated Mental Test, was defined based on education-specific cutoff values.Compared with individuals with emmetropia, persons with myopia were almost twice as likely to have cognitive dysfunction (odds ratio 1.82; 95% confidence interval 1.05-3.15), after adjusting for age, sex, body mass index, income, education, and hours of reading and writing per day. Hyperopia was not associated with cognitive dysfunction. The association remained significant after further adjustment for uncorrected refractive errors or best-corrected visual acuity.Our results provide evidence on a novel association between myopia and cognitive dysfunction.
Diversification of business through the purchase of an innovative machine

The investment in question consists of the cost of new technology, which will allow the implementation of a new production process resulting in new products. Thanks to the implementation of the investment, the production process (world innovation) will be substantially changed and the offer will be extended to include a country-wide innovative product, which will be tools with a significantly higher level of innovation, produced on special order. The degree of difficulty in their execution narrows the number of suppliers to a very small number.
THE MIRAGE TOOLBOX: AN INTEGRATED ASSESSMENT TOOL FOR TEMPORARY STREAMS

The assessment of the ecological status of water bodies, as requires by the European Water Framework Directive, can raise a number of problems when applied to temporary streams. These problems are because of the particular physical, chemical and biological conditions resulting from the recurrent cessation of flow or even the complete drying of the stream beds. In such non-permanent water bodies, the reference quality standards developed for permanent streams may only be applicable under certain circumstances or may not be applicable at all. Work conducted within the collaborative EU-funded project Mediterranean Intermittent River ManAGEment (MIRAGE) has addressed most of these difficulties and has used diverse approachesto solve them. These approaches have been brought together inthe so-called MIRAGEToolbox. This toolbox consists of a series of methodologies that are designed to be used in a sequential manner to allow the establishment of the ecological and chemical status of temporary streams and to relate these findings to the hydrological status of the streams. The toolbox is intended to serve the following purposes: (i) the determination of the hydrological regime of the stream; (ii) the design of adequate schedules for biological andchemicalsamplingaccordingtotheaquaticstateofthestream;(iii)thefulfillmentofcriteriafordesigningreferenceconditionstations;(iv)the analysis of hydrological modifications of the stream regime (with the definition of the hydrological status); and (v) the development of new methods to measure the ecological status (including structural and functional methods) and chemical status when the stream’s hydrological conditions are far from those in permanent streams. Copyright © 2014 John Wiley & Sons, Ltd.
NON-AQUEOUS PIGMENT DISPERSIONS USING DISPERSION SYNERGISTS

Non-aqueous pigment dispersions exhibiting improved dispersion quality and/or stability were prepared for a specific selection of quinacridone pigments, diketopyrrolo-pyrrole pigments and azo pigments by using specific naphthol AS dispersion synergists. The non-aqueous pigment dispersions can be advantageously used in inkjet inks inkjet printing methods.
Pain Intensity and Pain Interference in Older Adults: Role of Gender, Obesity and Inflammation (P3.310)

Objectives: We examine whether the obesity and pain relationship is mediated by the inflammatory marker high-sensitivity C-reactive protein (hsCRP) and whether this relationship differs by sex. Participants included 667 community-residing adults over age 70, free of dementia enrolled in the Einstein Aging Study (EAS).
Background: Among older adults, pain intensity and pain interference are more common in women than men and associated with obesity and inflammatory markers.
Design/methods: Items from Medical-Outcomes-Study Short-Form 36 were used to measure pain intensity and pain interference in daily life. Ordinal logistic regression was used to assess the cross-sectional association among BMI, hsCRP levels, pain intensity and pain interference using gender-stratified models adjusted for demographic variables.
Results: In women, pain intensity was associated with obesity (BMI蠅30 vs. normal, OR=2.29, 95[percnt]CI 1.43-3.68) and higher hsCRP (OR=1.28, 95[percnt]CI 1.08-1.51). In a model with obesity and hsCRP, both remained significant but the association between hsCRP and pain intensity was somewhat attenuated. Obesity (OR=3.04, 95[percnt]CI 1.81-5.11) and higher hsCRP levels (OR=1.30, 95[percnt]CI 1.08-1.56) were also independently associated with greater pain interference in women. After adjustment for pain intensity and BMI, hsCRP was no longer associated with pain interference in women. Greater pain intensity and being overweight or obese continued to be significantly associated with pain interference in women. In men, obesity and hsCRP were not associated with pain intensity or pain interference.
Conclusions: In women, the relationship between obesity and higher levels of pain intensity or interference may be due, in part, to an increase in hsCRP. Disclosure: Dr. eslami has nothing to disclose. Dr. Katz has received research support from Bristol-Myers Squibb. Dr. White has nothing to disclose. Dr. Sundermann has nothing to disclose. Dr. Jiang has nothing to disclose. Dr. Ezzati has nothing to disclose. Dr. Lipton has received personal compensation for activities with Allergan, Inc., American Headache Society, Autonomic Technologies, Boston Scientific Corp., Bristol-Myers Squibb, CogniMed Inc., Colucid Pharmaceuticals, Eli Lilly & Company, eNeura Therape