SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Statistical multi-omics understanding of patient samples

Bioinformatic analysis is the biggest bottleneck in many genomic medicine projects. Our objective is to enable researchers to dramatically increase statistically informed use of personal multi-omic data in medicine. Soon, multiple types of omic technologies will be applied to 100,000s of patient-derived samples, with the three-stage goal of better understanding disease biology, discovery of new interventions, and personalizing the choice of treatment options. Our interdisciplinary team of biostatisticians, bioinformaticians, software developers and physician-scientists will address the analysis bottleneck with statistically and computationally sound methods. The SOUND consortium will (i) develop widely used and excellent bioinformatic and statistical methods and open source software for common but challenging tasks, including data pre-processing, data integration, statistical inference, visual presentation, and publication-quality reporting; (ii) introduce novel approaches to ground breaking multi-omics applications in oncology and medical genetics; (iii) develop interoperable data structures and software interfaces that enable seamless combination of tools; (iv) support a collaborative international academic and industry developer community; (v) enable rapid development and execution of high-quality software; (vi) lower the barrier to entry into this transdisciplinary field by providing simple, robust, easy-to-use solutions; and (vii) develop a training programme with regular courses and comprehensive online tutorials. Our aim is to create the de facto standard toolkit used in every clinical research lab for statistically informed analysis of personal multi-omic data. SOUND will increase research and innovation opportunities by reducing barriers of entry to genomic medicine across academic, healthcare and commercial sectors by translating in a rapid and efficient manner complex and innovative analytical approaches into modular, interoperable, reusable applications.
A Mathematical Model Based on an Adaptive Neuro-Fuzzy Inference System for Matrixes Including Indomethacin

This study is concerned about prediction of dissolution rate of Insoluble drugs from solid dispersion (SD) polymer matrixes by an Adaptive Neuro-Fuzzy Inference System (ANFIS). Polyethylene Glycols (PEGs) as the SD with different molecular weights were provided and dissolution rate of indomethacin (IND) was obtained experimentally. A USP dissolution method was used to monitor the dissolution profiles of matrixes. The numbers of rules were trained in a systematic procedure using the experimental data. Comparison of IND dissolution rate from different matrixes, Area under the Curve (AUC) of absorbance vs. time diagrams in the first 25 min for 72 different samples was determined. Results show a high correlation between observed and predicted data (r2=0.85). The calculated root mean square error for the results of the ANFIS model is equal to 1.02. The index of area AUC in the first 25 min is more repeatable. It seems that the model has practical value and different ratios of polymer for the desired dissolution rate can be predicted or having different polymer ratios in the matrix can predict the dissolution rate of IND. this method can be suggested for other pharmaceuticals formulations to save time and money to achieve the best formula.
Internationalisation of StoresAce

StoresAce’s internationalisation project integrates a plan of marketing innovation and organizational innovation actions, valuing e-commerce and digital transformation, aiming to strengthen the company’s capacity for internationalisation and enhancing its exporting capacity.
Spatiotemporal analysis of the atmospheric and surface urban heat islands of the Metropolitan Area of Toluca, Mexico

The dynamic of consolidation of urban areas in Latin America has allowed that almost 80% of the population concentrates in cities; this has produced changes in land covers and modified regional climate, propitiating the appearance of urban heat islands. The Metropolitan Area of Toluca, State of Mexico, Mexico, holds the fifth national place in population size and experiences this process, because of this, the objective is to analyze and compare the spatiotemporal characteristics of the atmospheric urban heat island obtained from data gathered from 12 urban and rural weather stations with the surface urban heat island obtained from the digital processing of four Landsat 8 images. Results show the year-round presence of night-time atmospheric urban heat islands, which reach a peak in autumn (up to 6 °C). Daytime atmospheric urban heat islands occur in summer and autumn with a maximum intensity of 4 °C. For their part, surface urban heat islands occur in spring, summer and autumn and reach maximums of 19 °C in intensity. A strong correlation was found between wetness and surface temperature (coefficient of determination, 0.8) in spring and winter. Soil wetness directly impacts the formation of weak urban heat islands in dry season, and intense ones in wet season, while the green areas and the winds affect the spatial distribution of the same.
The diagnosis of healthcare policy problems in Korea

The definition of a policy problem is important in all stages of the policy processes, and especially in presidential election seasons, which usually open the political window. We propose priorities among the policy problems of Korean healthcare by the positioning approach, which compares Korea with Organization for Economic Cooperation and Development (OECD) countries using OECD health data. The range of positioning is 1 to -1 where 1 is the best or highest level among OECD countries, 0 is the average level, and -1 is the worst or lowest level. The positioning results show that the overall health status of Korea is good (positioning=0.34), but the suicide rate (-1.00) is a major problem. Healthcare human resources are scarce (-0.46), but rapidly increasing. Hospital beds and medical equipments are over-supplied (respectively 0.37, 0.33), but medical equipments that are utilized mainly in tertiary hospitals are below average. The utilization of healthcare is at the top level in doctors’ consultations (0.97) and average length of stay (0.65). The quality of in-patient care is good (0.35), but quality of out-patient care is poor (-0.36). Healthcare costs are low (-0.73), but their growth rate is high. Among healthcare costs, the policy problems are large pharmaceutical expenditures and many households with catastrophic expenditures. This study determined the priorities of healthcare policy problems in Korea. The next step is to search for the factors that influence these policy problems and develop their solutions.
Rock specific hydraulic fracturing and matrix acidizing to enhance a geothermal system — Concepts and field results

Abstract Enhanced geothermal systems (EGS) are engineered reservoirs developed to extract economic amounts of heat from low permeability and/or porosity geothermal resources. To enhance the productivity of reservoirs, a site specific concept is necessary to actively make reservoir conditions profitable using specially adjusted stimulation treatments, such as multi fracture concepts and site specific well path design. The results of previously performed stimulation treatments in the geothermal research well GtGrSk4/05 at Gros Schonebeck, Germany are presented. The reservoir is located at a 4100–4300 m depth within the Lower Permian of the NE German Basin with a bottom-hole temperature of 150 °C. The reservoir rock is classified by two lithological units from bottom to top: volcanic rocks (andesitic rocks) and siliciclastics ranging from conglomerates to fine-grained sandstones (fluvial sediments). The stimulation treatments included multiple hydraulic stimulations and an acid treatment. In order to initiate a cross-flow from the sandstone layer, the hydraulic stimulations were performed in different depth sections (two in the sandstone section and one in the underlying volcanic section). In low permeability volcanic rocks, a cyclic hydraulic fracturing treatment was performed over 6 days in conjunction with adding quartz in low concentrations to maintain a sustainable fracture performance. Flow rates of up to 150 l/s were realized, and a total of 13,170 m3 of water was injected. A hydraulic connection to the sandstone layer was successfully achieved in this way. However, monitoring of the water level in the offsetting well EGrSk3/90, which is 475 m apart at the final depth, showed a very rapid water level increase due to the stimulation treatment. This can be explained by a connected fault zone within the volcanic rocks. Two gel-proppant treatments were performed in the slightly higher permeability sandstones to obtain long-term access to the reservoir rocks. During each treatment, a total of 100 ton of high strength proppants was injected with 500 m3 of cross-linked gel. The subsequent production test in conjunction with flowmeter logging showed an improvement of productivity by a factor of more than 4. Due to assumed residual drilling mud (constituents: calcite, dolomite, and aragonite) in the near-wellbore vicinity, an acid matrix stimulation was performed thereafter using a coil tubing unit. The following nitrogen lift test demonstrated another increase of productivity by 30–50% to an overall increase by a factor of 5.5–6.2.
The relationship between impulsivity and suicide among rural youths aged 15–35 years: a case–control psychological autopsy study

In China, the gender ratio of suicide rates did not match the Western patterns, which was higher for females than males. However, the rural men were at relatively high risk of suicide in Liaoning province. Impulsivity was an important factor of suicide behaviors, but there was a lack of studies in China. This research aimed to study the relationship between impulsive personality traits and suicidal behavior among Chinese rural youths. Suicides were consecutively sampled from six randomly selected counties in Liaoning Province in China. Between 2005 and 2007, a total of 162 suicide victims were enrolled in the study along with 162 community controls matched for age, gender, and location. The psychological autopsy method was used to collect data from informants knowledgeable about the selected suicide victims and controls. The results showed the suicide victims in the study were more likely to demonstrate dysfunctional impulsivity and less likely to demonstrate functional impulsivity compared with the controls. Mental disorders, acute negative life events, and dysfunctional impulsivity contributed to the risk of suicide; educational and functional impulsivity were protective factors. Suicide prevention efforts in rural China may address impulsivity.
Simulación de una start up en el ambito de IOT

The main objective of the project is to go deeper into the Internet of Things (IoT) specifically in the management of Smart Homes and design a business plan as realistic as possible. The project consists of an introduction to this new technology and shows which are its most representative segments. It also includes a definition of the identity of the company, the services it intends to give and subsequently an analysis of the market through a marketing and financial plan. What it aims to demonstrate is that there is a real business opportunity in an expanding market in which there are still many things to develop and discover.
TEXTILE MACHINE HAVING A DRAFTING UNIT

An operating section of a textile machine (100) drafts fibre material and outputs it to a processing section (110). The textile machine (100) has a controller or is coupled to such a controller, which controls the operating section and a plurality of lighting elements (2, 3, 3a, 3b, 4-7) according to a lighting scenario such that the lighting elements (2, 3, 3a, 3b, 4-7) indicate: - filling states of fibre-material stores (201) located upstream of the drafting unit (103), - a processing direction, - soiling, - deviations in the fibre material, - number and/or size of thicker areas in the fibre material, - the operating state of a sensor system of the textile machine (100), - number of cans located in a can deposition device (110), - a worn state of at least one drafting unit upper roller, - proposed maintenance, - a proposed replacement of a wearing part, - a position of a detected fibre-material break, - a frequency of detected fibre-material breaks, and/or - the presence • of a fibre-material break between the drafting unit (103) and fibre-material store (201), • of a can change and/or of the lack of a fibre-material store at the can deposition device (110), and/or • of a fibre-material backup.
Vínculos entre Sexualidad y Afectividad en la Educación en Ciencias Naturales: Perspectivas de Docentes en Formación Inicial en la Región Sur de Colombia

Este trabajo aborda concepciones sobre sexualidad humana desde una construcción afectivo-sexual, que tienen futuros profesores de ciencias naturales en la región sur de Colombia. Así, a partir de una metodología mixta, se caracterizaron concepciones iniciales y finales de 50 docentes en formación matriculados en el curso de Didáctica de las Ciencias en el segundo semestre de 2020. Para ello, se diseñó y validó un cuestionario con 22 preguntas, agrupando 21 categorías temáticas, de las cuales, cuatro se desarrollan en este escrito. Las categorías se definieron bajo un sistema de emergencia, utilizando la técnica de análisis de contenido. Asimismo, en el marco de una Dimensión Afectivo-Sexual de la Educación para la Salud, y buscando movilizar las concepciones del profesorado, se implementó una secuencia didáctica basada en Cuestiones Sociocientíficas. Los resultados muestran que la propuesta formativa ha contribuido a la progresión de las concepciones de los participantes, pasando de posiciones en las cuales la sexualidad se limitaba a una cuestión de naturaleza biológica de tipo eugenésico, a tendencias de pensamiento reflexivas y críticas, en donde el profesorado reconoce una perspectiva biopsicosocial del fenómeno estudiado. Es decir, que la enseñanza de temas relacionados con la sexualidad desde las ciencias naturales pasó de ser un tema clínico-preventivo a una posibilidad de potenciar el aprendizaje sociocientífico cuando se piensa en una ciencia humana y sensible.
Perception–Action based design for urban accessibility: principles for inclusive design grounded in an understanding of first-person control of locomotion in the urban setting

The project will translate basic research in cognitive science to problems in urban planning and design. It will employ empirical and theoretical methods to deliver a set of design recommendations addressing the question: how can we design urban spaces that are accessible to all?

The basic research question is: how does an individual perceive that a road is crossable? The empirical programme, to be carried out at the University of Cincinnati, will proceed from an analysis of the attentional structure inherent to specific road-crossing tasks. Using virtual-reality, it will investigate, (1) how pedestrians decide whether it is safe to begin crossing under conditions of uncertainty about future movements of other road-users, and (2) how pedestrians negotiate junctions where safe locomotion requires an awareness of vehicles that may be approaching from multiple directions, including from behind. This will enable the creation of new measurement techniques, including measures of head turns and whole-body acceleration as indexes of perceptual uncertainty.

The project's theoretical programme, to be developed primarily at UCL's Bartlett School of Architecture, will generate a set of tools for guiding and analysing the design of roads. The project will culminate with the delivery of a document aimed at designers, presenting a set of recommendations for building accessible urban spaces. These recommendations will be based on a coherent, empirically-grounded understanding of the perceptual processes involved, and will be of particular relevance for designing infrastructure schemes where traffic modalities interact, for which existing guidelines can often be inadequate or unclear, e.g. for cycle lanes, pedestrian crossings, and shared spaces. This project, and the training envisaged, will allow me to establish myself as an expert in action-oriented psychological concepts and their real-world applications.
Future all aviation cns technology (fact)

The project FACT (Future All Aviation CNS Technology) relates to SESAR-ER4-24-2019: Innovation in CNS to enable Digitalised Operations. It addresses all application areas listed in the Call Topic 24, except the area 4 (Manned and un-manned aircraft protection from non-cooperative targets). It will bring a much needed update to CNS technology, and build the bridge between future U-space services (expecting fully digital and highly automated) and conventional ATM systems considering both technological and users’ perspectives. The main overall objective(s) of the project FACT is to increase safety, security, efficiency, and robustness of future air traffic environment through development of integrated CNS functional architecture supporting the use of common performance based approach for CNS functions addressing needs of large spectrum of airspace users across varied operational environments. It will address and bring benefits for both existing and new airspace users such as drones or urban air mobility. 

From technical perspective, the project will mainly focus on the innovative use of existing technology bricks, potentially adapted from adjacent industrial areas such as automotive or telecommunication. Interesting examples of such new CNS enablers are the envisioned use of 3G/4G/5G for communication and localization, OneWEB for low cost satellite communication, or Aeromacs as a new technology standardised by aviation for airport operations. This approach will allow the project to achieve technical performance goals at a lower development cost, and offer something that can find the aviation market in the shortest possible time. The project consortium brings together a balanced combination of industrial, operational, and academic knowhow, enabling it to address this challenging task.
BICYCLO-PYRAZOLES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM

Bicyclo-pyrazole compounds of formula (I), as herein defined, are useful for treating diseases linked to disregulated protein kinases.
Technology advancement of ocean energy devices through innovative development of electrical systems to increase performance and reliability

Life cycle cost of electricity generated by marine renewable technologies is determined by multiple factors including energy production capability, capital costs, and operating and maintenance (O&M) costs, as well as multiple other logistical, permitting, environmental, and finance cost factors. ORPC’s direct experience has been that operating and maintenance costs are dominant in the cost structure. It is clear that for marine renewable energy systems to be commercially viable they must demonstrate exceptionally high reliability and availability. ORPC is now addressing these cost, efficiency and reliability issues in order to achieve commercial status. This Project is a critical next step in commercialization of ORPC’s hydrokinetic power system technology for the European market. Ultimate Project goals are to develop a complete power transfer system from prime mover to electrical grid with normal maintenance intervals of greater than five years, and availability of greater than 98%. Intermediate goals are to deliver a system with design maintenance intervals of greater than five years, and availability greater than 96%. The projects primary objectives are listed below:
1. Develop wet gap electrical generator design capable of operating in seawater flooded condition
2. Develop advanced bearings and seal designs for hydrokinetic machines
3. Develop and implement control strategies to maximize power output and power quality for multiple prime mover designs
4.  Develop and implement advanced health monitoring system
5. Validate the system design work by integrated full scale lab testing of system
6. Integrate these components into a baseline ORPC hydrokinetic turbine and assess associated economic improvements
7. Disseminate Project results and findings
Exploring the Role of Topological Frustration in Actin Refolding with Molecular Simulations

Actin plays crucial roles in the life of the cell while being notorious for its inability to reach a functional conformation without the help of assistant proteins. In eukaryotes, for example, the cytosolic chaperonin containing TCP-1 (CCT) and prefoldin (PFD) are required for actin folding assistance and prevention of protein aggregation in the crowded cellular environment. The folding of non-native actin is known to occur in a number of steps, but the reasons underlying its folding difficulty are unknown. Because a full, atomistic-level, investigation of the kinetics and thermodynamics of folding of such a large molecule is beyond computational reach, we focused our investigation on the role of topological frustration on the folding of actin. Namely, we studied the (re)folding of actin using simulations of a variant self-organized polymer model (SOP-DH) starting from a stretched state, leading to results that correlate well with experimentally driven conclusions and allowing us to make a number of testable predictions. Primarily, our simulations reveal that the successful refolding of the C-terminus end of actin occurs through a zipping process in which the α-helices wind up turn by turn upon formation of their native tertiary contacts. In turn, an early formation of the helical structure in this region of the chain has deleterious effects for actin's refolding fitness. Moreover, the C-terminus refolding is a very rare event in our simulations, in agreement with the large activation barrier predicted on the basis of experimental studies of actin unfolding in EDTA. We also discovered that subdomain 4 has a low refolding probability, which can help explain why many of the non-native actin target binding sites for CCT and PFD are located within this subdomain.