SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
ADENOPATÍA CERVICAL EN PACIENTE CON VIH: REPORTE DE UN CASO HOSPITAL DOCENTE PROVINCIAL AMBATO

Las adenopatías son crecimientos de cadenas ganglionares que se presentan en diferentes patologías presentes en procesos infecciosos e infiltraciones neoplásicas o en estado de inmunosupresión en pacientes con serología positiva para el Virus de Inmunodeficiencia Humana. Se presenta el caso de paciente masculino de 47 años, que presenta desde hace tres meses, deposiciones diarreicas, líquidas abundantes de mal olor, tos seca, significativo deterioro del estado general, caquexia, cuadros febriles nocturnos y diaforesis. Se añadió epigastralgia urente, los últimos quince días, crecimiento ganglionar en cadenas cervicales bilaterales y disfagia. Paciente acude a hospital básico, donde realizaron un diagnóstico serológico con inmuno ensayo enzimático (ELISA) para del Virus de Inmunodeficiencia Humana, motivo por el cual fue transferido al Hospital Ambato para confirmación y tratamiento. Paciente al examen físico: caquéctico, deshidratado, taquicárdico, secreción retronasal blanquecina, placas blanquecinas a nivel de pilares amigdalinos anteriores, adenopatías cervicales bilaterales dolorosas, abdomen doloroso a nivel de epigastrio. Se complementaron los estudios confirmándose el diagnóstico de síndrome de inmunodeficiencia adquirida, leishmaniasis ganglionar y tuberculosis ganglionar. El presente caso tiene relevancia en el campo de la docencia – médica debido a que el paciente presentóadenopatías en cadenas ganglionares cervicales el médico debe realizar el diagnóstico diferencial entre patologías frecuentes y atípicas, ademásde cuadros infecciosos: virales, bacterianos incluyendo tuberculosis, micóticos y parasitarios, así como coinfecciones de etiología poco común que agravan el estado de inmunodepresión. Es importante tener la sospecha clínica para establecer el de adenopatías en pacientes inmunodeprimidos, a fin de que el diagnóstico sea oportuno y el tratamiento instaurado el más adecuado.
LINING TUBE FOR THE RESTORATION OF FLUID-CONDUCTING LINE SYSTEMS

The invention relates to a prefabricated lining tube for the restoration of fluid-conducting line systems, containing at least one fiber strip soaked with a single-component epoxy resin that cures by means of chain-growth polymerization.
Refugees’ Economic Integration through Social Entrepreneurship

REInSER brings together 8 project partners from academia, business support organisations and local authorities gathering different expertise, knowledges and skills in six countries of the ADRION area, namely, Slovenia, Italy, Greece, BiH, Serbia and Croatia. The project aims at tapping the potential of networking and knowledge transfer of transnational as well as cross-sectional cooperation of key stakeholders; the project strategic partnership is striving to find a sustainable solution for the pressing issue of refugees and asylum seekers. The main objective of REInSER is to improve their economic, and consequently wider, integration in host societies of ADRION programme area by using approaches of social economy and in particular social entrepreneurship. The long-term objective is to enhance possibilities for refugees to become active economic actors and agents of their own integration in given host society on one hand and to contribute to the local and regional sustainable economic development by generating employment and supporting the creation of new social responsible businesses on the other hand. REInSER main outputs involve:

1.the creation of an innovative transnational cooperation network which will bring together national, regional and local governments, governmental bodies, NGOs, social entrepreneurs, academics and refugees in a common programme as the first of its kind in ADRION region. Additionally, transn.exchange of knowledge from study trips, gathered best practices and experimental social ecosystem will be established through pilot actions and the insights from their evaluation, as well as the introduction of social innovation approaches supported by a broad range of local stakeholders. This will generate possibilities for acquisition of long-term competencies of direct and indirect beneficiaries; and enable 

2.to prepare holistic transnational strategy and action plan for successful integration of refugees in host societies’ economies.
DECK OR SLAB ANCHOR HOUSING POWER SUPPLY FOR POOL AND OTHER HIGH-MOISTURE OPERATING ENVIRONMENT POWERED DEVICES

Embodiments of the present disclosure include an anchor assembly configured for installation in a high-moisture environment, comprising an engaging compartment configured to receive a powered accessory and damper vibrations associated with the powered accessory, and a coupling portion housing a power supply, wherein the power supply is configured to provide wireless power to the powered accessory located in the engaging compartment.
Desarrollo en armonía ambiental: El caso de la Vereda Peñas Blancas del municipio de Arcabuco, Boyacá.

In order to generate knowledge as close to reality (holistic) of a clearly defined territory and become a strategic ecosystem in the Andean group, was chosen to deepen their biophysical, environmental and man look in a constructed through knowledge dialogue and a joint methodological assessment, so a scenario offuture prospect. The project aims to ensure sustainability and development inorder to remain consistent with the diverse life in man there is content to beacting comptroller positive nature and chained to life as a single (Odum, 1972). This article helps to identify the problems and potentials of all, in the natureculture (Gomez, 2009), in order to promote the realization of shares in projectsthat improve living conditions of the inhabitants, with a rational use environment. Is the partial result of the fieldwork pilot project entitled Diagnosis of historical and social practices and cultural, technological, agricultural and participation of women in the village of Penas Blancas Arcabuco Township. Boyaca.
Translating extracellular microRNA into clinical biomarkers for drug-induced toxicity: from high-throughput profiling to validation

Over the past 5 years, extracellular microRNAs (miRNAs) are being vigorously explored as injury biomarkers, including drug-induced cardiotoxicity, hepatotoxicity and nephrotoxicity. Currently, the development of miRNAs as clinical biomarkers has been hindered by the lack of standardization. Therefore, extracellular miRNA-based biomarkers have not been embraced as diagnostic tools. Each platform has its strengths and weaknesses when working with low-input-amount RNA samples from body fluids; the selection of a miRNA quantification approach should be based on the study design. The following review provides a summary of the extracellular miRNA release and stability in body fluids, performances of different miRNA quantification platforms, existing clinical gold standards for drug-induced tissue damage and translation of the miRNA biomarkers from the nonclinical to clinical setting.
Ground-Breaking two-phase cooling solution for electrical and hybrid vehicles

ALLATHERM is a Spanish company dedicated to the development of services and products for thermal management systems for a wide range of applications in the energy, scientific, telecommunication, automotive, aerospace, and defence industries. Over the last two years, ALLATHERM has developed ALTOM, a hermetically sealed closed 2-phase heat transfer loop for electronic components cooling. ALLATHERM has taken the 2-phase spacecraft thermal control concept and brought it to terrestrial vehicles with a modular ground-breaking approach. ALTOM is an efficient (fully passive), standardised, flexible (multiple configurations), cost-effective (>400€saved per vehicle), robust (no moving parts) and non-toxic system that manages thermal control in power electronics for terrestrial applications (electric and hybrid vehicles-EV/HEVs-).
According to the IEA, EV/HEVs stock is projected to reach 200 Million units by 2030. To achieve these numbers, EV/HEVs powertrain manufactures are required to increase the efficiency, lower cost and standardise their thermal management systems for the electronic components (engine, batteries, and invertor).  ALTOM heat loops, which have already proven its capacity to solve all these needs, will reach the market by 2020 selling 65,000 units and generating a profit of 11.7M€ during the first 5 years. ALTOM will directly target EV/HEV and powertrain manufacturers’ needs all across Europe since their market is not focused on a specific geographical area. With ALTOM market launch we will contribute to the achievement of 60% emission reduction in transport within the European Union by 2050, targeted in the 2011 Transport White Paper. Moreover, ALTOM boosts Europe´s transition towards a circular economy as it is framed in the “end-of-life vehicles”, “batteries and accumulators” and “waste on electrical and electronic equipment”, encouraging global competitiveness and sustainable economic growth.
Traditional Chinese Medicine for the treatment of influenza: a systematic review and Meta-analysis of randomized controlled trials

To justify the clinical use of Traditional Chinese Medicine (TCM) in the treatment of influenza.MEDLINE, EMBASE, Chinese Biomedical Literature Database, China National Knowledgeln-frastructure Database, China Science and Technology Journal Database, Wanfang Database and the Cochrane Database of Systematic Reviews were searched from the date of inception until January 1, 2013, for the literature on treatment of influenza with TCM.A total of 7 randomized controlled trials were identified and reviewed. Of these trials, 2 compared a (modified) prescription of TCM with oseltacmivir and 5 compared a patent traditional Chinese drug with oseltamivir. Based on the Meta-analysis, compared to oseltamivir, the (modified) prescription had similar effect in defervescence [WMD = 5.66, 95% CI (- 32.02, 43.35), P = 0.77] and viral sheddingWMD = - 6.21, 95% CI (- 84.19, 71.76), P = 0.88], and the patent traditional Chinese drug also had similar effect in viral shedding [WMD = - 0.24, 95% CI (- 4.79, 4.31), P = 0.92] but more effective in defervescence [WMD = - 4.65, 95%CI (- 8.91, - 0.38),P = 0.03].TCM has potential positive effects in the treatment of influenza.
European training network for in situ imaging of dynamic processes in heterogeneous subsurface environments

The ENIGMA network will train a new generation of young researchers in the development of innovative sensors, field survey techniques and inverse modelling approaches. This will enhance our ability to understand and monitor dynamic subsurface processes that are key to the protection and sustainable use of water resources. ENIGMA focuses mainly on critical zone observation, but the anticipated technological developments and scientific findings will also contribute to monitor and model the environmental footprint of an increasing range of subsurface activities, including large-scale water abstraction and storage, enhanced geothermal systems and subsurface waste and carbon storage. While many subsurface structure imaging methods are now mature and broadly used in research and practice, our ability to resolve and monitor subsurface fluxes and processes, including solute transport, heat transfer and biochemical reactions, is much more limited. The shift from classical structure characterization to dynamic process imaging, driven by ENIGMA, will require the development of multi-scale hydrogeophysical methods with adequate sensitivity, spatial and temporal resolution, and novel inverse modelling concepts. For this, ENIGMA will gather (i) world-leading academic teams and emerging companies that develop innovative sensors and hydrogeophysical inversion methods, (ii) experts in subsurface process upscaling and modelling, and (iii) highly instrumented field infrastructures for in-situ experimentation and validation. ENIGMA will thus create a creative and entrepreneurial environment for trainees to develop integrated approaches to water management with interdisciplinary field-sensing methods and novel modelling techniques. ENIGMA will foster EU and international cooperation in the water area by creating new links between hydrogeological observatories, academic research groups, innovative industries and water managers for high-level scientific and professional training.
Abstract 5628: Novel cell permeable peptide inhibitors of PELP1 oncogenic functions

Estrogen receptor (ERα) is the fundamental transcription factor in breast cancer progression and a majority of breast cancers start as ERα positive. Therapies targeting ERα are effective; however, many eventually develop resistance and recur as metastases. ERα signaling is mediated by coregulator proteins that can have altered expression and/or function that promotes therapy resistance and metastasis by enhancing hormone-independent ERα signaling and by epigenetic changes. An alternative strategy for inhibiting ERα signaling in therapy resistant and metastatic tumors is to inhibit the function of ERα coregulators. PELP1 is an ERα coactivator and proto-oncogene which is overexpressed in breast cancer, promotes breast cancer progression by epigenetic changes at ERα target genes and is an independent marker of poor prognosis and breast cancer survival. The objective of this study is to develop an inhibitor of PELP1-mediated ERα coactivator functions. Since PELP1 lacks any known enzymatic activities, we targeted PELP1 protein-protein interactions to inhibit its oncogenic functions. We used a yeast two-hybrid system to screen a library of random peptides (∼10-7) fused to a transcriptional activation domain and identified 23 peptides with high affinity for PELP1. Two of these PELP1-inhibiting peptides (PIP-1 and PIP-2) significantly block PELP1 coactivator functions and we used a TAT-peptide fusion of PIPs to deliver the peptides into cells. Cellular uptake of the TAT- PIP was confirmed by fluorescent microscopy and biotin-avidin peptide pull-down assays confirmed PELP1-PIP binding. Both PIP- 1 and -2 significantly inhibited PELP1-mediated proliferation in two ERα-positive breast cancer cells (MCF7 and ZR75). A GenBank search revealed homology of PIPs with the methyltransferase G9a (Bat8/KMT1C/EHMT2) that is commonly overexpressed in aggressive breast cancer, contributes to epigenetic silencing of tumor suppressors and promotes cancer invasion and metastasis. In vivo co-immunoprecipitation analysis and an in vitro binding assay confirmed PELP1 interaction with G9a. Peptide competition assays indicated that the TAT-fused peptides could interrupt PELP1-G9a interaction. Both PIP-1 and -2 substantially inhibited PELP1-mediated cell invasion/migration in Boyden chamber assays. Interestingly, disrupting PELP1-G9a interaction with PIPs sensitized resistant cells to hormonal therapy. Mechanistic studies revealed that PELP1-G9a interactions play a critical role in epigenetic changes in therapy resistant cells. In conclusion, our studies identified a novel inhibitor of PELP1 that can be used for therapeutic targeting of ERα-coregulator driven cancer progression and therapy resistance. This work was supported by the NIH grant CA095681 and CPRIT pre-doctoral fellowship. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 5628. doi:1538-7445.AM2012-5628
Remember when it rained – Schooling responses to shocks in India

Abstract Despite long-standing international agreements like the Millennium Development Goals, 264 million children in developing countries are not enrolled in school, and children in rural areas remain twice as likely to be out of school as children in urban areas. One potential explanation for this pattern is that children’s education in rural areas is vulnerable to weather shocks, but there is no consensus about whether rainfall shocks help or harm school enrollment in the existing literature. This paper explores whether changes in the relationship between rainfall shocks and schooling outcomes over time can explain the different results in the literature by using household survey data from India across three decades. My study finds that adverse rainfall shocks have an increasingly stronger positive impact on school enrollment over time, whereas enrollment is increasingly falling after positive rainfall shocks. This effect is stronger for girls than for boys, more pronounced for older children, and is consistent with an increase in the importance of opportunity costs of a child’s time in more recent years. Children may have to drop out of school when employment opportunities are more readily available after a positive rainfall shock, but are able to go to school when jobs are scarce. These results offer a potential explanation for the different results in the literature, where studies on countries with higher economic development tend to find results consistent with an opportunity cost story, whereas this is not the case for studies on countries with a lower level of development. The results suggest that policymakers need to pay close attention to the obstacles faced by girls and older children to make access to education universal, and should develop policy tools that incentivize households to send their children to school even when employment opportunities are readily available.
Abnormal heart rate recovery and chronotropic incompetence on submaximal exercise in COPD

Background: A delayed heart rate recovery (HRR) after graded and an attenuated heart rate response (chronotropic incompetence, CI) are markers of cardiac autonomic dysfunction and predict cardiovascular mortality. The latter also characterize COPD. Therefore we hypothesized that decreased HRR and CI should coexist in COPD.

Methods: After lung function evaluation, 39 stable COPD patients and 11 healthy controls underwent submaximal cycle ergometry. Heart rate was measured at peak exercise and at 1-min recovery. Abnormal HRR was defined as a recovery of ≤12 beats in the first minute post-exercise. Chronotropic incompetence was evaluated by measuring the Chronotropic Response Index (CRI = \[(peak heart rate - resting heart rate)/\] \[(220 - age) – (resting heart rate)\].

Results: The HRR was 13±9.1 beats and 23.9±5.9 beats in patients and controls (p<0.001) while CRI was 44.59±13.9 and 61.2±5.1 (p<0.01) in these groups, respectively. An abnormal HRR was observed in 29 (74.4%) of the patients. The HRR and CRI were significantly correlated. Both HRR and CRI showed a decreasing trend with increasing GOLD severity and BODE index. On univariate analysis, HRR was negatively associated with age, pack-years of smoking and diffusion capacity/alveolar volume (DLCO/VA). On multiple logistic regression, after adjusting for other variables, a reduced DLCO/VA was the only significant, though weak, determinant of reduced HRR.

Conclusions: Patients with COPD have a decreased HRR and CI on exercise indicating autonomic dysfunction. These well-established markers of cardiovascular morbidity and mortality should be clinically useful tools for risk stratification and prognostication in patients with COPD.
Exploring the australian reptile hypervolume: assembly and evolution of a continental fauna

All forms of Life on Earth exist in their own unique niches defined by their appearance, behaviour, and preferred environment. These niches allow species to coexist and for biodiversity to accumulate at local, regional, and continental scales. By quantifying these niches in many dimensions we can build a hypervolume that describes diversity through variation in niche axes. While high dimensional trait data of this kind exist for birds and mammals, reptiles—which account for 30% of terrestrial vertebrate species—are poorly represented in these data and empirical studies of niche evolution. In EARtH I aim to fill this knowledge gap by building a high dimensional niche database for all Australian lizard and snake species (15 morphological measurements, 10 environmental variables, >1,000 species, ~10% of global reptile richness). Both biotic (character displacement through competition) and abiotic (habitat filtering) influences are expected to have predictable effects on niche evolution. By investigating hypervolume properties through time and across Australian reptile radiations I will test for the influence of biotic interactions on niche evolution. This novel approach will provide insight into the community assembly process which has made Australia the world’s richest reptile hotspot. By comparing trends across the Australian landscape I will also test for associations between hypervolume occupancy, phylogenetic turnover,  and climate. Undertaking this fellowship will help me to develop comparative methods, museum curatorial, and reproducibility skills that complement my background in phylogenetics and macroevolution, making me a stronger and more independent researcher. In return, I look forward to sharing my skills and findings with the staff and visitors of the Natural History Museum in London and beyond.
The burden of mental disorders, substance use disorders and self-harm among young people in Europe, 1990–2019: Findings from the Global Burden of Disease Study 2019

Mental health is a public health issue for European young people, with great heterogeneity in resource allocation. Representative population-based studies are needed. The Global Burden of Disease (GBD) Study 2019 provides internationally comparable information on trends in the health status of populations and changes in the leading causes of disease burden over time.Prevalence, incidence, Years Lived with Disability (YLDs) and Years of Life Lost (YLLs) from mental disorders (MDs), substance use disorders (SUDs) and self-harm were estimated for young people aged 10-24 years in 31 European countries. Rates per 100,000 population, percentage changes in 1990-2019, 95% Uncertainty Intervals (UIs), and correlations with Sociodemographic Index (SDI), were estimated.In 2019, rates per 100,000 population were 16,983 (95% UI 12,823 - 21,630) for MDs, 3,891 (3,020 - 4,905) for SUDs, and 89·1 (63·8 - 123·1) for self-harm. In terms of disability, anxiety contributed to 647·3 (432-912·3) YLDs, while in terms of premature death, self-harm contributed to 319·6 (248·9-412·8) YLLs, per 100,000 population. Over the 30 years studied, YLDs increased in eating disorders (14·9%;9·4-20·1) and drug use disorders (16·9%;8·9-26·3), and decreased in idiopathic developmental intellectual disability (-29·1%;23·8-38·5). YLLs decreased in self-harm (-27·9%;38·3-18·7). Variations were found by sex, age-group and country. The burden of SUDs and self-harm was higher in countries with lower SDI, MDs were associated with SUDs.Mental health conditions represent an important burden among young people living in Europe. National policies should strengthen mental health, with a specific focus on young people.The Bill and Melinda Gates Foundation.