SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Understanding the complexity and architecture in protein ubiquitination

The posttranslational modification of proteins with polyubiquitin regulates virtually all aspects of cell biology. This versatility arises from eight distinct linkage types between individual ubiquitin moieties in polyubiquitin, which co-exist in cells, are independently regulated, and eventually determine the fate of the modified protein. However, ubiquitin chain architecture can be highly complex, and the extent of ‘chain branching’ is unknown. Moreover, ubiquitin also undergoes phosphorylation and acetylation, which can dramatically alter its function. 

A true appreciation of the complexity in the ubiquitin code can only be achieved when all above aspects are considered, and only then will it be possible to assign cellular readouts to distinct ubiquitination events and differentiate between ubiquitin signals in cells. 

While the complexity of ubiquitination is daunting, work from many laboratories including my own has exemplified how basic biochemistry, a detailed understanding of mechanism and quantitative mass-spectrometry allows us to study, and eventually understand, the ubiquitin code. 

In this proposal, new methods and approaches are outlined that will allow a detailed monitoring of polyubiquitin chain architectures from cellular samples (AIM 1), and also lead to an in depth understanding of additional posttranslational modifications, such as ubiquitin phosphorylation and acetylation in cells (AIM 2). Moreover, new research tools for unstudied K6- and K33-linked polyubiquitin will give insights into cellular roles for these linkage types (AIM 3). Our studies will focus on ubiquitination events on mitochondria leading to mitophagy, where unstudied K6-linked chains as well as phospho-ubiquitin are part of complex chain architectures, and mechanisms of signalling are still unclear. Our work will reveal fundamental principles in ubiquitination, and are of high medical relevance due to the links to Parkinson’s disease, infectious disease, and cancer.
ELECTRONIC EQUIPMENT FOR A WIRELESS COMMUNICATION SYSTEM

The disclosure relates to an electronic device and a wireless communication method in a wireless communication system. According to the disclosure, the electronic device comprises one or more processing circuits. The processing circuit is configured to execute the following operation: configure timing mapping information between a downlink subframe carrying uplink scheduling grant signaling and an uplink subframe carrying uplink transmission, comprising physical uplink shared channel PUSCH transmission, scheduled by the uplink scheduling grant signaling, and performed on an unlicensed channel by user equipment in the wireless communication system. By means of the electronic device and the wireless communication method in the disclosure, a timing mapping relationship between a downlink subframe carrying uplink scheduling grant signaling and an uplink subframe carrying uplink transmission comprising PUSCH transmission can be determined, thereby realizing effective utilization of an unlicensed channel.
Depresión, ansiedad y estado nutricional en adolescentes de la ciudad de Temuco

La adolescencia es una etapa de cambios biológicos, psicológicos y sociales. Estos cambios constituyen un posible espacio de vulnerabilidad para presentar trastornos de salud mental. Esta investigación tuvo como objetivo analizar la relación entre depresión, ansiedad y estado nutricional en adolescentes. Participaron 61 sujetos pertenecientes a la ciudad de Temuco, Chile. Se utilizó el instrumento BDI-II para medir niveles de depresión y BAI para medir niveles de ansiedad, finalizando con el cálculo de IMC. Presentar un IMC &gt;24,9 es indicador de sobrepeso y un IMC mayor a 29,9, de obesidad. Los resultados obtenidos mostraron que el 83,6% de los participantes presentó síntomas depresivos, en el cual, el 58,8% obtuvo un IMC&gt; 24,9. El 88,5% presentó sintomatología ansiosa, donde el 59,3% alcanzó un IMC&gt; 24,9. Se encontró una alta correlación entre depresión y ansiedad en contraste con las variables de salud mental e IMC donde no se encontraron correlaciones significativas.
Experimental Study on Hysteretic Behavior for Plate-Reinforced Connections

8 plate-reinforced connections are manufactured at 1/2 scale and then tested under low-cyclic loadings to study their hysteretic behavior, and numerical simultation with ANSYS are applied based on the experimental results. Failure patterns, energy dissipation, hysteretic behavior and skeleton curves are comparatively studied by changing the dimensions of the reinforced plates. Results show:(1)the plastic hinge be formed 1/3-1/4 beam depth from the end of reinforced plate and is obvious, there are serious local buckling in the flange and web, and there is no fracture in the beam-to-column welding;(2)The geometric parameters of reinforced plate have important effect to the bearing capacity and ductility of connections. With the increase of length and thickness of reinforced plate, the bearing capacity increases and hysteretic behavior and ductility factor decreases;(3)When the length of reinforced plate is bigger than the design requirements, there is brittle failure in the panel zone, which lead to decrease of capacity of energy dissipation and equivalent viscous damp coefficient;(4)Recommended parameter scope: the recommended length of reinforced plate(flange-plate and cover-plate) is defined as 0.5-0.8 times beam depth, the recommended thickness of flange-plate is 1.2-1.4 times flange and the recommended thickness of cover-plate is 0.7-1.2 times flange.
Paleogenetic extraction and analysis from challenging environments

The field of ancient human DNA (aDNA) has rapidly undergone changes over the last decade. These changes have been spurred on through the use of high-throughput sequencing (HTS) technologies. These methodological advancements have increased our understanding of the human lineage to depths thought impossible only a short time ago. For example, aDNA research has shown how modern humans are related to our archaic ancestors, indicating significant admixture events throughout our evolutionary history with the Neanderthals and other now-extinct archaic species. However, to achieve these results, the ancient material has been exceptionally well preserved, owing to favorable, i.e. cold, environmental conditions. For many parts of the world, however, the environmental conditions remain a barrier to the extraction and analysis of aDNA. 
The nature of aDNA research is inherently interdisciplinary, whereby several branches of inquiry, such as archaeology or genetics, attempt to answer similar evolutionary questions from different perspectives. This proposal attempts to use advanced extraction and sampling methods for aDNA from challenging environments in order to broaden the scope of paleogenetics research. Although continental Europe has gained significantly from these advances, for other parts of the world, such as Southeast Asia and the Near East, this has been more difficult due to formidable preservation conditions. The goal of this proposal is to build on promising preliminary results that target a specific bone in the human skull in order to gain a better understanding surrounding the dynamics of aDNA preservation, while at the same time, gain insight into the evolutionary histories of peoples from warm and humid, or warm and arid, locations. Our proposal incorporates state-of-the-art HTS techniques, includes a comprehensive training program with international collaborators, and benefits from a two-way transfer of knowledge between host and researcher.
(0333000169) BIOENPRO4TO-SMART SOLUTIONS FOR SMART COMMUNITIES: BIOENERGIE E PRODOTTI SOSTENIBILI DI CHIMICA VERDE (OUTPUT) DALLA VALORIZZAZIONE INTEGRATA DI RIFIUTI URBANI, INDUSTRIALI, BIOMASSE E ACQUE REFLUE (INPUT), ATTRAVERSO MODULI FUNZIONALI INTELLIGENTI

(0333000169) BIOENPRO4TO-SMART SOLUTIONS FOR SMART COMMUNITIES: BIOENERGIE E PRODOTTI SOSTENIBILI DI CHIMICA VERDE (OUTPUT) DALLA VALORIZZAZIONE INTEGRATA DI RIFIUTI URBANI, INDUSTRIALI, BIOMASSE E ACQUE REFLUE (INPUT), ATTRAVERSO MODULI FUNZIONALI INTELLIGENTI
The scale and significance of early animal husbandry in sw europe: development of aninterdisciplinary high-resolution approach to the investigation of livestock diets and herding practices.

In the history of early farming, the absolute scale and relative importance of livestock and crop husbandry, their degree of
integration, and their landscape impact are largely obscure. To address this issue, GeoFodder will develop for the first time
an interdisciplinary methodology that integrates geoarchaeological and archaeobotanical techniques for archaeological
recognition of leafy browse and leafy fodder (currently not directly detectable) and for assessing the preservation of different
plant resource types, with the ultimate aim of reconstructing early livestock diet and herding practices. To achieve these
objectives, an innovative ethnoarchaeological and experimental programme will study present-day livestock penning
deposits (for which herding practices, animal diets and depositional processes are known) to determine how dietary and
other plant components are altered and partly preserved through ingestion, organic decay and (to sterilize pens) burning.
This will generate a suite of geoarchaeological and archaeobotanical proxies, for different plant types (taxa, anatomical
parts, seasons) with different preservation histories (ingested, decayed, burnt), that will then be applied to analysis of
prehistoric penning deposits in Iberian caves and rock-shelters. The resulting semi-quantitative data on livestock diet in
particular contexts will underpin modelling of the qualitative and temporal dimensions of early livestock grazing/
browsing and foddering at intra- and inter-site levels to enable assessment of the potential scale of herding and thus of the
likely mobility of livestock and relative importance of crops and livestock in early farming. Geofodder will thus advance our
understanding of early livestock husbandry in the SW Mediterranean, contribute to assessment of the long-term landscape
impact and sustainability of herding, and establish methodological standards for investigating such questions in other regions
and periods.
Improvements in power transmission by dynamo-electric machines

550,590. Transmitting mechanical power. ENGLISH ELECTRIC CO., Ltd., and CARNEGIE, H. S. June 11, 1941, No. 7397. [Class 38 (iv)] An electromagnetic coupling, of the kind in which torque is transmitted by the electromagnetic interaction between a field system and a secondary system in which the field induces current during continuous slip, is combined with a dynamo-electric generator and a motor element whereby the rotation of the output shaft may be reversed with or without changes in speed ratio. Fig. 1 shows a shaft 1 carrying two field elements 5, 7 the first forming with a secondary element 6 on a shaft 2 an electromagnetic coupling and the second co-operating with a stator 8 to form an alternator supplying current to a motor stator 10 co-operating with a rotor 11 on the shaft 2. Various structural arrangements of the elements 7, 8, 10, 11 are possible and the motor or generator may constitute separate machines in driving association with the shafts. The electrical control comprises primarily a switch 13 for selective energization of the field elements and may comprise a switch 15 whereby in successive positions (1) a forward drive, (2) braking by application of D.C. to the .motor stator, and (3) reverse drive are obtained. A pole changing switch 17 may give a change of speed. Other methods of braking may be used. The generator may be a synchronous alternator and the motor an induction motor or synchronous-induction motor.
Fieldtech: technology for next-generation characterization of optical fields

The proposed project is dedicated to bringing technology for next generation characterization of optical fields to a market level. The technology, based on recent innovations at LMU, will facilitate simple optoelectronic devices, for e.g. carrier-envelope-phase (CEP) measurements, enabling the characterization of few-cycle pulses at a single laser shot level. Contemporary CEP-meter techniques, i.e. the f-2f interferometer and Sterero-ATI technique, have limitations, including they do not easily offer extension of single-shot measurements towards increasing repetition rates (beyond 100 kHz), have limited operation wavelengths, or involve a sophisticated apparatus, which is bulky and expensive. Based on our recent innovation, the realization of a simple phase meter that consists of only a few components and can even work in ambient air, we propose to explore bringing this and also its related field-metrology technology to the market to overcome such limitations. 
We aim to improve the long-term stability of the device, to enhance the signal sensitivity, and to decrease the temporal response time for high-repetition single-shot CEP detection and retrieval. These include a new design of the device structure, a proper encapsulation of the core device including electromagnetic shielding, the incorporation of fast electronics components, and the development of a user-friendly software. The newly developed device will undergo a series of tests with different ultrafast laser sources both in the near and mid-infrared wavelength range and at repetition rate up to at least 100 kHz. In parallel to the S&T development, we will carry out the ‘go-to-market’ activities, which include securing the IP, standardization and modulation of the product, the analysis of worldwide potential market, discovery of supply and distribution channels, and formulation of sales strategies.
Absorbing the potential of wood waste in eu regions and industrial bio-based ecosystems

BioReg project proposes to create a platform of stakeholders who are able to influence and develop their regions towards bio-based industries and products. 

Demonstrator case studies have been selected among European regions – Gothenburg, (SE); Karlsruhe, Baden-Wurttember (Ge), Lombardy, Emilia-Romagna (IT), North West England (UK) and Vorarlberg and Syria, Austria. Those have set up renewable wood waste-based systems at different stages of the waste wood value chain including different wood waste source, pre-sorting, sorting, collection, recycling and wood waste treatment (to materials, biochemicals or biofuels) as well as the different gradings and regional wood waste composition in each country. 

3 recipient regions were selected for this project in regards to their unused waste wood potential:  Normandy (France), Lublin (Poland), Andalucia (Spain). 

The BioReg platform will function on two levels. On the EU level: best practices in terms of strategies and technologies as well as implementing mechanisms will be shared with the beneficiary recipient regions on the project and disseminated to many other potential regions in the EU (EUBIA). The platform will will encourage the collaboration of members and stakeholders on the European level. On the regional level: the best practices will be replicated in the three beneficiary regions. The proposal offers collaboration with regional existing clusters, constructive dialogue with regional authorities and policy makers, industrial and RTD establishments in the recipient regions. It will mobilize the recipient regions to develop the existing potential for industrial innovative projects and build bio-based ecosystems. Industries, regions and investors will be brought together to establish an efficient dialogue so that demand and supply can be aligned and large impact projects can be realized.

The project proposes mechanisms to engage the stakeholders in collaboration also after the EU funding on BioReg is over.
APPARATUS AND METHODS FOR INSTALLING A SUBSTRUCTURE

There is described apparatus for use in installing a substructure, and related methods. In embodiments of the invention, the apparatus comprises a positioning device attached to a leg of the substructure. The substructure comprises at least one leg to be mounted to at least one base, and the positioning device comprising at least one jack for supporting the leg upon the base, such that at least part of the weight of the substructure is supported on the base via the jack. In this way, relative movement between the leg and the base can be reduced, to allow permanent mounting of the leg to the base for example by using a curable material.
Foreword. The Knowledge Economy: The Present Future

All the statistics and evaluations show that the Knowledge Economy is our future. However, a close look at the developed economies demonstrates that the Knowledge Economy is already here, shaping our present time. Although there are many definitions of this new economic framework, their core content stresses the importance of data, information, and knowledge in the production of goods and delivering services in creating value for society. For instance, Powell and Snellman (2004, p.1999) define the knowledge economy as “production and services based on knowledge-intensive activities that contribute to an accelerated pace of technical and scientific advance, as well as a rapid obsolescence. The key component of the knowledge economy is a greater reliance on intellectual capabilities than on physical inputs or natural resources”. In the knowledge economy, knowledge becomes a strategic resource (Davenport & Prusak, 2000; Nonaka & Takeuchi, 1995) and knowledge strategies contribute directly to the competitive advantage (Bratianu & Bolisani, 2015). In this new economy, data, information, and knowledge are the driving forces of development and the knowledge economy is the engine of the global economy growth...
The predictive value of HGPIN and ASAP for the subsequent diagnosis of prostate cancer in the Reduction by Dutasteride of Cancer Events (REDUCE) study.

4561 Background: REDUCE was a 4-year, randomized placebo (pbo) controlled study of prostate cancer (PCa) risk reduction with once daily dutasteride 0.5 mg (dut). This analysis examines the effect of dut on initial detection of high-grade prostatic intraepithelial neoplasia (HGPIN) and/or atypical small acinar proliferation (ASAP) and the incidence of PCa on subsequent biopsy. Methods: Eligible men were aged 50–75 years, had a serum PSA 2.5–10.0 ng/ml, and a single, negative (no PCa, HGPIN or ASAP) biopsy of 6–12 cores in the 6 months prior to enrollment (4126 subjects randomized to pbo, 4105 dut). Ten-core prostate biopsies were taken at 2 and 4 years and examined for evidence of PCa. For subjects with 2-year biopsies and no PCa (2866 pbo, 2867 dut), the initial incidence of ASAP, HGPIN (without ASAP), and ASAP or HGPIN was compared between treatment groups using Fisher's exact test. PCa incidence in a subsequent biopsy was also compared between treatment groups with Fisher's exact test. Results: PCa inci...
Vegetable ozone therapy crops sanitized naturally from seed to feed

Crop pests and disease have serious consequences for agriculture, in terms of economic losses and wastefulness of resources. In addition, according to the FAO, transboundary plant pests and diseases – growing in the last years because of globalization, trade and climate change, as well as reduced resilience in production systems due to decades of agricultural intensification - affect food crops, threatening food security. Agriculture is to be safe, healthy and sustainable, so it is essential to have healthy crops; they play a role in producing sufficient quantities of healthy foods and contribute to the quality of life.OXIR is an innovative technology for spraying aqueous ozone (O3) for disease control and sanitation of greenhouse crops, taking advantage of the powerful oxidation-based (hence non-selective) anti-pathogen action of ozone. OXIR offers two configurations adaptable to users’ needs a fixed and a mobile prototype, that will allow European farmers saving €6.000,00/ha/year due to reductions in chemicals and labour. Currently, existing solutions to fight crop pests and diseases include synthetic chemical pesticides – posing serious environmental concerns - and bio-pesticides – that are not strongly effective, as their pest spectrum is narrow. Compared to these solutions, OXIR is highly efficient against fungi and bacteria (85-99% removal) and viruses (90-99%); costs-effective: OXIR treatment saves working time (1 min. treatment; 20 min. safety interval) compared to biopesticides and chemicals; environmentally sustainable: OXIR is IPM compatible, sustainable, and does not leave polluting residues. The goal of the Phase 2 project is to upgrade OXIR from its current preproduction state to market readiness and develop the first commercial product.
Interstitium-On-A-Chip to explore its role in cancer metastasis

The annual number of metastatic cancer deaths and the cost of cancer treatment makes cancer research a priority for the European Union. One of the key factors in metastatic cancer is the ability of the cancer cells to migrate from a primary tumor to the blood vessels and lymphatics. A better understanding of how cancer cells interact with the microenvironment and migrate from blood vessels to the lymphatics to create distant metastases, is key for discovering efficient chemotherapy drugs that will cover the growing needs of the worldwide population. The possibility of developing biomimetic engineered devices to understand metastasis proliferation and testing of drugs is a crucial goal for the research community, both in science and medicine, translating to major benefits for future patients. Therefore, the goal of the ICE-METs project is to deliver, a novel engineered microfluidic biomimetic platform to monitor the migration and proliferation of cancer cells in metastasis.
The insect cochlea: a non-invasive path towards enhanced sound detectors

There is a critical need for high-resolution acoustic sensors for numerous applications in engineering/medicine.  The human cochlea has been a source of inspiration for acoustic sensors due its improved sensitivity, higher frequency range, and sharp frequency discrimination. Current methods for measuring cochlear mechanics are inherently invasive, and deep understanding of its process remains elusive, proving challenging its simulation in electromechanical devices. Yet cochlear organ for frequency selectivity is not unique to mammalian audition. A simpler analogous mechanism for frequency analysis was recently found in the ears of bush-crickets (insects). These insects are endowed with outer middle and inner ear, but unlike mammals their cochlea is small (~0.6 mm), uncoiled, and exceptionally accessible through transparent cuticle. These attributes facilitate the clean measurements of complex auditory processes impossible to attain in the mammalian cochlea, and open an exceptional opportunity for miniaturization and simplification of artificial acoustic sensors.

Using bush-crickets and relatives as model systems this project is designed to fulfil the following two main objectives: (1) to dissect the three ear components to i) identify the elements involved in acute hearing sensitivity, ii) characterise the role of multiple sound inputs in directional hearing, iii) associate the activation patterns of auditory afferents with mechanical waves in the insect cochlea. (2) Use experimental data to produce computer models and theoretical analogues of the insect cochlea to propose innovative alternatives in the design of acoustic sensors. By using a multi-disciplinary approach between biology, engineering, physics and mathematics, this project is designed to develop new technological improvements that constitute the grounds of the next-generation of miniature, super-sensitive acoustic sensors.