SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Gait Parameter Adjustments for Walking on a Treadmill at Preferred, Slower, and Faster Speeds in Older Adults with Down Syndrome

The combined effects of ligamentous laxity, hypotonia, and decrements associated with aging lead to stability-enhancing foot placement adaptations during routine overground walking at a younger age in adults with Down syndrome (DS) compared to their peers with typical development (TD). Our purpose here was to examine real-time adaptations in older adults with DS by testing their responses to walking on a treadmill at their preferred speed and at speeds slower and faster than preferred. We found that older adults with DS were able to adapt their gait to slower and faster than preferred treadmill speeds; however, they maintained their stability-enhancing foot placements at all speeds compared to their peers with TD. All adults adapted their gait patterns similarly in response to faster and slower than preferred treadmill-walking speeds. They increased stride frequency and stride length, maintained step width, and decreased percent stance as treadmill speed increased. Older adults with DS, however, adjusted their stride frequencies significantly less than their peers with TD. Our results show that older adults with DS have the capacity to adapt their gait parameters in response to different walking speeds while also supporting the need for intervention to increase gait stability.
Implementation of innovative wood furniture production technology in PPUH “LARIX” Dargiewicz, Mackiewicz Sp.J.

The planned project is the result of many years of experience of PPUH LARIX in the industry of birch and alder furniture manufacturers, and especially the problems identified with the increasing number of customer complaints related to rheological deformation of furniture. For their reduction, the company intends to implement innovative technology for the production of wooden countertops, and as a result, offer significantly improved deformation-resistant furniture. This will be innovation: process and product on a regional and national scale developed as a result of the R & D work carried out in close cooperation with the State Higher Vocational School in Suwałki, which were submitted for the patent. The project is a pro-development, pro-innovative, green and pro-social project which directly affects the company’s potential and competitiveness and is in line with the main objective of the Priority Axis I RPOWP for 2014-2020. The use of state-of-the-art machines and processing equipment in the design will result in a competitive advantage over similar entities in the industry. Our advantage will be that we will produce innovative wooden furniture with significantly improved mechanical properties, i.e. significantly improved resistance to rheological deformation and consequently extended durability. All this will respect the principles of environmental protection and its resources through the application of the process innovation envisaged by the project. In this way we will obtain the furniture quality that is not available to us (and competition) so far, which will allow us to compete effectively. The recipients of the offer will be our existing customers. The correctness of the implementation of the task will be measured by a series of indicators described in point. The VI of the application.
Functional diversity of t cells

T cells have a central role in most adaptive immune responses, including immunity to infection, cancer, and autoimmunity. Increasing evidence shows that even resting steady-state T cells form many different subsets with unique functions. Variable level of self-reactivity and previous antigenic exposure are most likely two major determinants of the T-cell diversity. However, the number, identity, and biological function of steady-state T-cell subsets are still very incompletely understood. Receptors to ligands from TNF and B7 families exhibit variable expression among T-cell subsets and are important regulators of T-cell fate decisions. We hypothesize that pathways triggered by these receptors substantially contribute to the functional diversity of T cells.The FunDiT project uses a set of novel tools to systematically identify steady-state CD8+ T cell subsets and characterize their biological roles. The project has three complementary objectives.
(1) Identification of CD8+ T cell subsets. We will identify subsets based on single cell gene expression profiling. We will determine the role of self and foreign antigens in the formation of these subsets and match corresponding subsets between mice and humans.
(2) Role of particular subsets in the immune response. We will compare antigenic responses of particular subsets using our novel model allowing inducible expression of a defined TCR. The activity of T-cell subsets in three disease models (infection, cancer, autoimmunity) will be characterized.
(3) Characterization of key costimulatory/inhibitory pathways. We will use our novel mass spectrometry-based approach to identify receptors and signaling molecules involved in the signaling by ligands from TNF and B7 families in T cells.
The results will provide understanding of the adaptive immunity in particular disease context and resolve long-standing questions concerning the roles of T-cell diversity in protective immunity and tolerance to healthy tissues and tumors.
The lmu research fellowship program: promoting excellent early-stage postdoctoral researchers at lmu munich

As a leading European research university, Ludwig-Maximilians-Universitaet (LMU) Muenchen is committed to providing optimal conditions and reliable career paths for early-career researchers. To this end, the University aims to expand its successful LMU Research Fellowship Program, which provides excellent research options and professional training conditions for outstanding international postdoctoral researchers from any field of research. The program gives Research Fellows the opportunity to carry out their own independent research project with the support of an LMU professor. As part of COFUND, the program will be differentiated into an incoming and a new outgoing fellowship scheme and provide additional international and cross-sectoral training opportunities to foster the mobility of Research Fellows. Incoming fellows will be able to undertake secondments of three to six months to international academic partner institutions. Alternatively, they may collaborate with a non-academic partner institution in the Greater Munich area or elsewhere. Outgoing fellowships will be offered to excellent postdocs with a doctorate from LMU in order to promote the scientific exchange with non-EU countries. Fellows will be seconded to an academic partner institution in a Third Country during an outgoing phase of 12 months and will be reintegrated into a department at LMU during their 12-month return phase. As a rule, incoming and outgoing fellowships will be awarded for two years. In exceptional cases, funding for an additional year may be granted for projects whose scope and originality require additional research time as part of 2+1 fellowships. In summary, the expansion of the LMU Research Fellowships will enhance the career development of international postdocs, extend LMU’s regional and international network of collaborations and contribute to the circulation of outstanding researchers and scientific innovations as part of the realisation of the European Research Area.
Elemental and Isotopic Imaging of Biological Samples Using NanoSIMS

AbstractWith its low detection limits and the ability to analyze most of the elements in the periodic table, secondary ion mass spectrometry (SIMS) represents one of the most versatile in situ analytical techniques available, and recent developments have resulted in significant advantages for the use of imaging mass spectrometry in biological and biomedical research. Increases in spatial resolution and sensitivity allow detailed interrogation of samples at relevant scales and chemical concentrations. Advances in dynamic SIMS, specifically with the advent of NanoSIMS, now allow the tracking of stable isotopes within biological systems at subcellular length scales, while static SIMS combines subcellular imaging with molecular identification. In this chapter, we present an introduction to the SIMS technique, with particular reference to NanoSIMS, and discuss its application in biological and biomedical research.Key wordsNanoSIMSStable isotopesBiologicalDynamic SIMS
INSERÇÃO DE IMIGRANTES NO MERCADO DE TRABALHO DOS MUNICÍPIOS DE PEQUENO PORTE DO SUDESTE BRASILEIRO

A região Sudeste, a mais dinâmica do Brasil em todo o século XX, responde por uma parcela expressiva da economia brasileira. Em 2010, essa região possuía 1.668 municípios, dentre eles grandes metrópoles, como São Paulo e Rio de Janeiro, que envolvem uma extraordinária infraestrutura produtiva. Este estudo teve como objetivo principal avaliar a força de trabalho migrante nos municípios de pequeno porte do Sudeste, nas três últimas décadas, com intuito de apontar novas tendências econômicas, bem como refletir sobre o papel desses municípios como centralidades emergentes. Utilizou-se os microdados do censo demográfico de 1991, 2000 e 2010 dado sua cobertura geográfica e amplo leque de variáveis que concentram, possibilitam o delineamento de uma rede de fluxos migratórios de trabalhadores. Os resultados permitiram indicar aspectos amplos do comportamento econômico regional no Sudeste brasileiro e demonstraram a existência de arranjos espaciais compostos por pequenos municípios protagonistas de práticas não unicamente centradas na agricultura, como em outrora. RESUMO: A região Sudeste, a mais dinâmica do Brasil em todo o século XX, responde por uma parcela expressiva da economia brasileira. Em 2010, essa região possuía 1.668 municípios, dentre eles grandes metrópoles, como São Paulo e Rio de Janeiro, que envolvem uma extraordinária infraestrutura produtiva. Este estudo teve como objetivo principal avaliar a força de trabalho migrante nos municípios de pequeno porte do Sudeste, nas três últimas décadas, com intuito de apontar novas tendências econômicas, bem como refletir sobre o papel desses municípios como centralidades emergentes. Utilizou-se os microdados do censo demográfico de 1991, 2000 e 2010 dado sua cobertura geográfica e amplo leque de variáveis que concentram, possibilitam o delineamento de uma rede de fluxos migratórios de trabalhadores. Os resultados permitiram indicar aspectos amplos do comportamento econômico regional no Sudeste brasileiro e demonstraram a existência de arranjos espaciais compostos por pequenos municípios protagonistas de práticas não unicamente centradas na agricultura, como em outrora.
Thickness reconstruction of nuclear power plant pipes with flow-accelerated corrosion damage using laser ultrasonic wavenumber imaging

The pipeline is an essential part of nuclear and other power plants. Designed to operate for decades, the pipeline is susceptible to multiple types of damage due to working in a high pressure, high temperature, and highly corrosive environment. Therefore, it requires regular inspection. The issue of many current nondestructive testing systems for pipelines is the use of a one-dimensional scan mechanism along the longitudinal direction of the pipe, which is incompatible with the two-dimensional curvature of elbow pipes, yet it is at these places in which the flow changes directions inside the elbow pipes that a common type of damage occurs: flow-accelerated corrosion damage. In this article, flow-accelerated corrosion damage is visualized using the Ultrasonic Wavenumber Imaging algorithm, which maps the dominant local spectroscopic wavenumber of the wavefield at a particular mode and a particular frequency. In previous studies, the mode and frequency were chosen empirically. In this article, a novel theoretical study is presented to optimize the two input parameters of Ultrasonic Wavenumber Imaging based on a sensitivity analysis of the spectroscopic wavenumber with respect to the change in thickness of the structural base. Additionally, an inverse method is proposed to estimate the thickness of the structure based on the Ultrasonic Wavenumber Imaging map.
Shift2Rail ip4 enabling mobility as a service and seamless passenger experience

In a fast moving environment, access to information about options for travel that is instant, easy to use, attractive to customers, and authoritative is vital. Therefore a one-stop-mobility shop, acting as a personal mobility assistant, is the key to offer citizens an alternative that challenges car ownership. New technologies can play a crucial role for a large scale and stable business operation of Mobility as a Service (MaaS) at a global level. Interoperability Framework, Travel Shopping, Booking and Ticketing, Validation, Payment and Trip Tracking are technologies developed within Shift2Rail IP4 to meet the engineering challenges associated with leveraging current actions on establishing open-data policies and data exchange standardization. Given this, the main goal of Shift2MaaS is to support the uptake of the IP4 technology and overcome the technical and non-technical barriers for the adoption of new integrated mobility platforms. Shift2MaaS aims to support the introduction of Shift2Rail IP4 technology within the MaaS context by analysing the needs in terms of technology enablers of the different stakeholders involved, and demonstrating the benefits of IP4 through pilot demonstrators of collective and shared mobility services and the seamless passenger experience. To this end, Shift2MaaS will co-design and validate advanced use-cases for the deployment and implementation of COHESIVE solutions. The Shift2MaaS impact is validated and assessed in three European sites, all strongly engaged in the intermodality and MaaS domain, and setting specific actions on existing or new MaaS schemes. Shift2MaaS thus builds on and adds to previous projects by makes the connection to real environments. Shift2MaaS will also analyse regulatory and behavioural aspects of the IP4 multimodal transport services market place on business logics, on the creation of new business models and on the behavioural / demand response of passengers; contributing to an overall economic assessment.
Determinants of Land Conservation Technologies Adoption among Arable Crop Farmers in Nigeria: A Multinomial Logit Approach

As parts of the efforts to reduce land degradation and hence improve farm productivity, farmers in the area were introduced to various land conservation technologies. The study was thus conducted to investigate the determinants of land conservation technologies in the area. Data collected through a multi-stage sampling procedure were analysed with the aid of descriptive statistics and multinomial logit model. Findings revealed significant difference between socio-economic characteristics of the respondents such as age (p?0.01), household size (p?0.01), farm size (p?0.01), value of livestock (p?0.01) and off-farm income (p?0.01). Findings further revealed that level of education, extension contact and land ownership significantly influenced farmers adoption of mulching, cover cropping and tree planting respectively. On the other hand, while age of respondents reduced farmers’ adoption of mulching and tree planting, membership of association increased the adoption of cover cropping. Government through her agencies and other development organizations should therefore put in place policy framework that would educate the farmers through regular extension contact and also carry out a review of land ownership rights in the study area. This would enhance farmers’ adoption of conservation options and hence, sustainable production.
Sub beati petri et nostra protectione suscipimus: re-framing the relations between rome and the kingdoms of portugal and aragon (eleventh-thirteenth centuries)

My research project will examine and compare the relations of the Papacy with Portugal and Aragon from the pontificate of Alexander II (1061-1073) to that of Innocent III (1198-1216). Portugal and Aragon have been chosen because were the only political realities in the Iberian Peninsula to enjoy the protection of St Peter in these centuries. These relationships have been interpreted as a feudal bond, but recent studies have started to challenge this image. This analysis will fit into and expand recent discussions of the relations between centre (Rome) and periphery, focusing on an ecclesiological perspective. To whom was the Apostolic See writing? And who was writing to Rome? Why? Did the letters concern practical or theoretical matters? What language and images were adopted by Rome to assert its primacy over Portugal and Aragon and what ecclesiological ideas? Was there ever a feudal bond between these political institutions and Rome? Or was the papacy only reacting to events, claiming a role that it could not play? Was there a particular style in use when writing to the pope? Did ecclesiastics and lay powers adopt similar or distinct formulas when writing to the Apostolic See? These are some of the questions the project aims to answer. Letters issued by the papal chancery are the main source for this kind of analysis because they always entailed the official view of the Roman church on a specific matter, showing the communication strategies and the ecclesiological ideas adopted by the Apostolic See to assert Roman primacy. Missives sent to the popes also played a decisive role in the creation of papal images. This project will shed light not only on the papacy and on the strategies adopted to support its claims of primacy, but also on views of the Roman church from a frontier of Christianity, which may (or may not) have been shared by the papacy itself.
Using Smartphones and Sensor Technologies to Automate Collection of Travel Data

This paper presents a data collection framework and its prototype application for personal activity–travel surveys through the use of smartphone sensors. The core components of the framework run on smartphones backed by cloud-based (online) services for data storage, information dissemination, and decision support. The framework employs machine-learning techniques to infer automatically activity types and travel modes with minimum interruption for the respondents. The three main components of the framework are (a) 24-h location data collection, (b) a dynamic land use database, and (c) a transportation mode identification component. The location logger is based on the smartphone network and can run for 24 h with minimal impact on smartphone battery life. The location logger is applicable equally in places where Global Positioning System signals are and are not available. The land use information is continuously updated from Internet location services such as Foursquare. The transportation mode identification module is able to distinguish six modes with 98.85% accuracy. The prototype application is conducted in the city of Toronto, Ontario, Canada, and the results clearly indicate the viability of this framework.
Microbial advanced biofuels production: overcoming emulsification challenges for large-scale operation

Isoprenoids and alkanes produced and secreted by microorganisms are emerging as an alternative biofuel for diesel and jet fuel replacements. In a similar way as for other bioprocesses comprising an organic liquid phase, the presence of microorganisms, medium composition, and process conditions may result in emulsion formation during fermentation, hindering product recovery. At the same time, a low-cost production process overcoming this challenge is required to make these advanced biofuels a feasible alternative. We review the main mechanisms and causes of emulsion formation during fermentation, because a better understanding on the microscale can give insights into how to improve large-scale processes and the process technology options that can address these challenges.
METHOD FOR CONTROLLING AN ENDODONTIC INSTRUMENT FOR ROOT CANAL TREATMENTS

The invention relates to a method for automatically controlling a root-canal cutting tool (4) of a root canal instrument (2), the root-canal cutting tool (4) being rotatable by a motor (6) and associated with a unit (8) for controlling the cutting torque (CP) or the torque distributed by the motor, the method including: rotating the root-canal cutting tool (4) in a first predetermined cutting direction (SI) until the torque (CP) reaches a predetermined maximum torque value, said maximum value being a function of the root-canal cutting tool (4) or of the motor (6); and, when the maximum torque value is reached, rotating the root-canal cutting tool (4) in a second direction (S2) opposite to the first cutting direction (SI) at a first predetermined angle of rotation; and then resuming the rotation of the root-canal cutting tool (4) in the first cutting direction (SI).
Bacterial evolution of hypersensitivity and resistance against antimicrobial peptides

Evolution of resistance towards a single drug simultaneously increases (cross-resistance) or decreases (collateral sensitivity) fitness to multiple other antimicrobial agents. The molecular mechanisms driving cross-resistance are relatively well described, but it remains largely unclear how frequently does genetic adaptation to a single drug increase the sensitivity to others and what the underlying molecular mechanisms of collateral sensitivity are. This proposal focuses on studying the bacterial evolution of resistance and collateral sensitivity against antimicrobial peptides (AMPs). Beyond their modulatory roles in the immune system, these naturally occurring peptides provide protection against pathogenic microbes, and are considered as promising novel alternatives to traditional antibiotics. However, there are concerns that evolution against therapeutic AMPs can readily develop and as a by-product this might compromise natural immunity. Our knowledge of these issues is limited due to the shortage of systematic evolutionary studies. Therefore, the three central questions we address are: Do bacteria resistant to multiple antibiotics become hypersensitive to certain antimicrobial peptides? What are the evolutionary mechanisms leading to AMP resistance and to what extent does this process induce cross-resistance/collateral sensitivity against other drugs? Last, are these evolutionary trade-offs predictable based on chemical and functional peptide properties? To investigate these issues rigorously, we integrate tools of laboratory evolution, high-throughput phenotypic assays, functional genomics, and computational systems biology. Our project will provide an insight into the evolutionary mechanisms that drive cross-resistance and collateral sensitivities with the aim to explore the vulnerable points of resistant bacteria. Another goal is to provide guidelines for the future design of antimicrobial peptides with desirable properties against bacterial pathogens.
GAS ENERGY MEASUREMENT METHOD AND RELATED APPARATUS

A method for determining an energy content of a hydrogen-rich gas mixture using a gas density meter (101) is provided. The method includes the steps of providing a vibratory gas density meter (101) and meter electronics (112) with the gas density meter (101). The meter electronics (112) communicate with at least one external input (116). The meter electronics (112) are configured to measure a density of the hydrogen- rich gas mixture, measure a specific gravity of the hydrogen-rich gas mixture, and derive a calorific value of the hydrogen-rich gas mixture using the derived specific gravity and a plurality of constant values.