SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Validation of actionable genomic aberrations in a paediatric oncology network for doctorate students

Pre-clinical drug development for paediatric cancers is very complex, resource intensive and requiring multi-disciplinary expertise and innovative approaches. The VAGABOND ITN, consisting of 12 academic and 6 non-academic partners from 8 European countries, aims to create a multidisciplinary and multi-sectoral program to validate new therapeutic interventions in paediatric cancer. This network will be sustainable embedded in the ITCC (Innovative Treatments for Children with Cancer) Consortium. The VAGABOND ITN will focus on 15 cutting-edge research projects studying molecular, epigenetic and immunological targets. All projects will (partly) include target identification, in vitro and in vivo validation, compound testing and preparation for clinical implementation. This consortium will highly stimulate international education and multi-disciplinary exchange of expertise in the different steps of pre-clinical drug development. This setting provides an opportunity for a unique European training network in which early stage researchers are equipped with a broad knowledge in pre-clinical drug development. Through this network students will gain access to other leading academic research groups, specialized multi-sectoral companies and the most innovative techniques and insights in the complexity of translational medicine to prepare them for future challenges in their career pathway. In this collaboration we will increase the commune expertise on tumour types and technical expertise for target validation. This will improve the implementation of interventions across paediatric cancer and strongly reduce the timeline from bench to the bedside.
How I treat warfarin-associated coagulopathy in patients with intracerebral hemorrhage

Abstract Intracerebral hemorrhage in patients with warfarin-associated coagulopathy is an increasingly common life-threatening condition that requires emergent management. The evolution of therapeutic options in this setting, as well as recently published guidelines, has resulted in some heterogeneity in recommendations by professional societies. This heterogeneity can be attributed to lack of evidence-based support for plasma therapy; the variability in availability of prothrombin complex concentrates; the variability in the coagulation factor levels and contents of prothrombin complex concentrates; ambiguity about the optimal dose and route of administration of vitamin K; and the lack of standardized clinical care pathways, particularly in community hospitals, for the management of these critical care patients. In this review, we summarize the relevant literature about these controversies and present recommendations for management of patients with warfarin-associated coagulopathy and intracerebral hemorrhage.
Treatment pathways of extrapulmonary patients diagnosed at a tertiary care hospital in Delhi, India

In order to put extrapulmonary tuberculosis patients early on treatment, it is important to study pathways, which these patients adopt in for seeking treatment.In order to study the treatment pathways of extrapulmonary patients and assess appropriate points for intervention, a cross-sectional study was conducted in chest clinic of a tertiary care hospital in Delhi.Factors associated with longer paths included reason for going to first health facility (nearness and known provider), availing more than one health facilities, presenting symptoms of fever, joint pain, nodular skin swelling and skin lesion. Self-referral to the chest clinic was associated with shorter paths. Lower level of education, occupation, non-serious perception of the disease and visiting five health facilities were significantly associated with patient delay of more than 3.5 weeks. Symptoms of fever, joint pain and skin lesion, visiting private health facility first, availing more than two health facilities and travelling distance of more than 100 km to reach chest clinic were significantly associated with the health facility delay of more than 4.5 weeks.Increasing public awareness, training of private practitioners and capacity building of government facilities will help in reducing delay.
Sustainable route for circularity of renewable polyesters

During the years it has been shown that the problem of the environmental impact due to the dispersion in the environment of organic materials recalcitrant to biodegradation (e.g. plastics, lubricants) can only be partially solved by collection and recycling strategies. In this respect, studies are needed that provide effective solutions, embracing the entire life cycle of the material, starting from its design, up to its ""end of life"". Thus, The RenEcoPol project aim is to develop alternative routes for recyclable polyester synthesis based on biobased building blocks using green processes such as biocatalysis. RenEcoPol first develops a strategy for the selection of monomers from renewable sources completed by a selection of the green catalysts for synthesis of polyesters possible candidates for different applications ranging from packaging to high performance materials. The new biobased polyesters will be characterized in detail by several analytical techniques for structure confirmation and assessment of the physico-chemical properties. In the third step the biodegradability in different natural and synthetic conditions of the synthesized materials will be evaluated and in the last step the development of a strategy for the recoverment of the components will be performed. Following all the steps the compliance to bioeconomy and circular economy criteria will be demonstarted. The RenEcoPol project will familiarize the researcher with bioinformatics, marine biotechnology and will promote her development as independent researcher and facilitate the acquisition of a stable research position in Europe.
PROCESS AND DEVICE FOR REGULATING THE TORQUE DERIVED FROM A DRIVE UNIT

A process and device are disclosed for regulating the torque (MIND) derived from a drive unit, whereby in a gear shifting unit a target torque value (MIG) is determined in accordance with a target torque value (MIFA) set by the driver. In addition, a limiting torque value is pre-set to protect the transmission and limit the torque derived from the drive unit.
The functional interaction of egfr and beta-catenin signalling in colorectal cancer: genetics, mechanisms, and therapeutic potential.

Monoclonal antibodies against the EGF receptor (EGFR) provide substantive benefit to colorectal cancer (CRC) patients. However, no genetic lesions that robustly predict ‘addiction’ to the EGFR pathway have been yet identified. Further, even in tumours that regress after EGFR blockade, subsets of drug-tolerant cells often linger and foster ‘minimal residual disease’ (MRD), which portends tumour relapse. 
Our preliminary evidence suggests that reliance on EGFR activity, as opposed to MRD persistence, could be assisted by genetically-based variations in transcription factor partnerships and activities, gene expression outputs, and biological fates controlled by the WNT/beta-catenin pathway. On such premises, BEAT (Beta-catenin and EGFR Abrogation Therapy) will elucidate the mechanisms of EGFR dependency, and escape from it, with the goal to identify biomarkers for more efficient clinical management of CRC and develop new therapies for MRD eradication. 
A multidisciplinary approach will be pursued spanning from integrative gene regulation analyses to functional genomics in vitro, pharmacological experiments in vivo, and clinical investigation, to address whether: (i) specific genetic alterations of the WNT pathway affect anti-EGFR sensitivity; (ii) combined neutralisation of EGFR and WNT signals fuels MRD deterioration; (iii) data from analysis of this synergy can lead to the discovery of clinically meaningful biomarkers with predictive and prognostic significance.
This proposal capitalises on a unique proprietary platform for high-content studies based on a large biobank of viable CRC samples, which ensures strong analytical power and unprecedented biological flexibility. By providing fresh insight into the mechanisms whereby WNT/beta-catenin signalling differentially sustains EGFR dependency or drug tolerance, the project is expected to put forward an innovative reinterpretation of CRC molecular bases and advance the rational application of more effective therapies.
Newbouldia laevis leaves extract: Nutritive value, Phytochemical constituent and effect on growth performance and faecal egg count reduction in West African Dwarf rams raised semi intensively

This study was conducted to assess the effect of Newbouldia laevis leaf extract on growth performance and faecal egg count of West African Dwarf sheep. A total of twenty four growing West African Dwarf rams between 12-15 months old and of balanced weight were used for the experiment. The rams were allotted to three treatment groups containing 8 animals per group, each group were drenched with Newbouldia laevis leaves extract at the rate of 0, 30, and 60 mgkg -1 of their body weight (BW) for three consecutive days in a week for 14 weeks. Data were collected on weekly performance and faecal egg count of experimental rams. The Newbouldia laevis leaves extract contained 55% moisture, 5.68% crude protein, 5.61% crude fat, 10.54% crude fibre, 2.15% total ash, 21.02% NFE and 20.22% NDF. It also had 0.00015 %, 0.00229 %, 39.2 %, 2.5 %, 0.00296 %, 2.92 %, 0.00286%, 0.00163%, 0.624%, 0.00044% and 0.00001 % of flavonoid, terpenoid, tannin, alkaloid, phytic acid, trypsin inhibitor, phenol, antioxidants, carotenoid, oxalate and cyanide, respectively. Animals drenched at 60 mg kg -1 body weight (BW) had the highest growth performance curve followed by those drenched at 30 mg kg -1 BW with animals on 0 mg kg -1 BW being the lowest. Irrespective of the level of drenching of the extract, the faecal egg count did not follow a particular trend. Hence, Newboudia laevis leaf extract had no effect on the faecal egg count of the WAD sheep raised semi intensively but have the capability of improving the growth rate of sheep. Keywords: Newbouldia laevis , Performance characteristics and faecal egg count.
Accuracy of Magnetic Resonance Imaging–Directed Frame-Based Stereotaxis

Abstract BACKGROUND: Accurate placement of a probe to the deep regions of the brain is an important part of neurosurgery. In the modern era, magnetic resonance image (MRI)-based target planning with frame-based stereotaxis is the most common technique. OBJECTIVE: To quantify the inaccuracy in MRI-guided frame-based stereotaxis and to assess the relative contributions of frame movements and MRI distortion. METHODS: The MRI-directed implantable guide-tube technique was used to place carbothane stylettes before implantation of the deep brain stimulation electrodes. The coordinates of target, dural entry point, and other brain landmarks were compared between preoperative and intraoperative MRIs to determine the inaccuracy. RESULTS: The mean 3-dimensional inaccuracy of the stylette at the target was 1.8 mm (95% confidence interval [CI], 1.5-2.1. In deep brain stimulation surgery, the accuracy in the x and y (axial) planes is important; the mean axial inaccuracy was 1.4 mm (95% CI, 1.1-1.8). The maximal mean deviation of the head frame compared with brain over 24.1 ± 1.8 hours was 0.9 mm (95% CI, 0.5-1.1). The mean 3-dimensional inaccuracy of the dural entry point of the stylette was 1.8 mm (95% CI, 1.5-2.1), which is identical to that of the target. CONCLUSION: Stylette positions did deviate from the plan, albeit by 1.4 mm in the axial plane and 1.8 mm in 3-dimensional space. There was no difference between the accuracies at the dura and the target approximately 70 mm deep in the brain, suggesting potential feasibility for accurate planning along the whole trajectory.
LAUNDRY DRIER

1515099 Rotary drum drier BOSCHSIEMENS HAUSGERATE GmbH 17 March 1977 [23 June 1976] 11323/77 Heading F4G A laundry drier comprising a drum 4 having an unperforated circumferential wall is mounted for rotation about a horizontal axis in a container 2 to define an annular space 7 therebetween, and air inlet and outlet channels 8, 9 communicating with space 7 are interconnected by a channel 12 external of the drum which contains a heater 13 and a blower 11. Vapour from the interior of the drum is led by a duct (18) to a condenser (20), see Fig. 2 (not shown), the duct being connected to an aperture in an end wall (21) of the drum. The aperture may comprise an axially located hollow spigot (17), or one or more offaxis apertures in the walls (21, 22) of the drum 4 and container 2.
Innovative 5-part haematology analyser for near-patient diagnostics

The INNOHEM project will develop and validate the first Complete Blood cell Count (CBC) haematology analyser including 5-part differential and reticulocytes (5-part analyser) for the decentralized, low-volume testing haematology market. Today, CBC tests are performed using either 3-part or 5-part analysers. The latter are growing in importance worldwide as they are able to provide much more detailed information about the medical condition of the patient. However, 5-part analysers are currently designed entirely for the high-volume testing market with complex, centralized laboratories equipped with large sample automation devices. Recognising market niche and a strong business opportunity, Boule will create a revolutionary point-of-care analyser that will provide reliable 5-part haematology results from a finger-stick blood sample. The new system will disrupt the existing marketplace by redefining the segment for the commercial application of 5-part analysers (from high-volume centralized testing to low-volume near-patient testing). 
The key need of physicians is the access to an easy-to-deploy analyser for 5-part CBC testing. The analyser should be designed for easy operation in smaller laboratory settings. The users’ needs will be met by creating a user-friendly diagnostic device that allows for low-volume, decentralized and near-patient testing. The Phase 1 project will develop a strategic business plan for the commercialisation of the new product. The Phase 2 project will validate the new diagnostic device. The EU added value will be generated by allowing physicians to make a rapid health assessment of the patient locally and take improved decisions concerning further diagnostic measures or immediate treatment strategy. This will ultimately lead to more personalized and cost-efficient approaches to healthcare on the EU level.
Advanced theranostic nanomedicines for oncology. development of new combinatorial therapies for primary and metastatic breast cancer.

Despite significant advances in  recent years, cancer remains the 2nd cause of death globally. Immunotherapy is an exciting new therapeutic approach that triggers natural immune response against cancer cells. Theranostics is an emerging therapeutic intervention, that uses dual (or multiple) purpose nanomedine, combining diagnostic and therapeutic effects within a single multifaceted formulation. ONCOTHERANOSTICS proposes the use of a novel theranostic agent to target key tumoral genes by siRNA and monitor the impact of the downregulation non-invasively in vivo. Specific aims include understanding the interplay between choline kinase and tumor escaping natural immune surveillance, and to develop new combinatorial therapies in a model of primary and metastatic triple negative breast cancer. We anticipate that successful completion of the project will result in significant advances in personalized tumor treatments, rendering safer strategies to treat cancer with a dual effect; boosting natural immune response and knocking down one of the main mechanisms of malignancy.
Dr. Pacheco is an organic chemist with expertise in MRI who will be trained (outgoing) in nanoparticle synthesis, non-MRI imaging techniques and advanced molecular biology/genetic approaches. Training will be transferred to the host European institution (incoming) by the establishment of a new research line in the emerging field of Theranostics.
ONCOTHERANOSTICS seeks to improve our understanding of cancer and how to personalize treatments, fostering the development of nanomedicine targeting specific genes in a way that can be assessed non-invasively.
ONCOTHERANOSTICS provides a multidisciplinary environment for cancer treatment, involving multifaceted nanomedicine, multimodal molecular imaging and molecular biology/genetic approaches. The proposal directly addresses the cross cutting priority of personalizing health and care established by H2020, reinforcing European competitiveness in cancer research.
Sensorless control method with relatively low frequency signal injection for low acoustic noise

In this paper, we proposed the new sensorless control approach with relatively low frequency signal injection to reduce acoustic noise and vibration. Filters that are classically used in signal processing of currents are the main obstacle to high dynamic performance and even it make unstable the control system when the signal frequency become low enough that is close to the bandwidth of current controller. To overcome these problems, we proposed to use model-based estimation method instead of filters. It is verified by experiments that dynamic performance of the sensorless control is improved by proposed method compare to the conventional filter-based method.
PRomoting Intergenerational learning in MEditerranean countries

Project in brief _x000D_
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Mediterranean silversmithing and gemmology products are sold under prestigious brands with an aura of exclusivity, cutting-edge creativity and superior quality, including the best of Mediterranean craftsmanship. Intertwined with the heritage are unique craft skills which have been handed down through generations of families and small businesses. Throughout the Mediterranean area, artisan skills and local economies are threatened as business moves manufacturing out and into Asia. A lack of innovative schemes to valorise the know-how and experience of senior silversmiths and gemmologists has been identified together with the need to foster professionalism of younger generations. This will ensure that valuable skills are not left to disappear but remain strong and vital parts of the economy and cultural heritage of the Mediterranean area. PR.I.ME project aims at supporting the intergenerational learning and business transfer while assessing and filling in skill gaps. In addition, it figures to encourage cross-fertilisation between regional identities and culture by clustering talents at Mediterranean Basin level. Through this approach, PR.I.ME hopes to foster local development and move from cultural competition amongst businesses to cultural collaboration to make Mediterranean creativity in the silver/goldsmithing creativity more visible internationally. _x000D_
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Specific objectives _x000D_
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• To foster intergenerational learning within gold/silversmiths _x000D_
• To develop transferable mentoring schemes for intergenerational learning and transfer of core skills in the gold/silversmithing and gemmology sectors
WIRELESS POWER TRANSMITTER AND WIRELESS POWER RECEIVER, AND OPERATION METHODS THEREFOR

A method for controlling a wireless power transmitter for charging a wireless power receiver may comprise the operations of: transmitting power for charging; receiving a first PRU dynamic signal indicating completion of charging, from the wireless power receiver, applying a beacon for detecting the wireless power receiver through a load change to a resonance circuit of the wireless power transmitter; receiving, from the wireless power receiver, a first advertisement signal including information indicating that charging is not requested; and ignoring the advertisement signal and maintaining application of the beacon.
The Relationship Between Bound Water and Carbohydrate Reserves in Association with Cellular Integrity in Fragaria vesca Stored Under Different Conditions

It has been recognized that high CO2 concentrations maintain the freshness of strawberries, reducing weight loss and the incidence of decay. Since strawberries have high toler- ance threshold to CO2, it is of interest to know what changes occur in cellular water distribution when the threshold is reached or exceeded. Moreover, as strawberries are prone to producing exudate during storage at low temperatures, appli- cation of technologies improving water retention is needed. Changes in bound water content were analyzed in relation to simple sugars, polyols, and fructooligosaccharides (FOS) in Fragaria vescastored at low temperature (0 °C) in the presence of 0, 20, or 40 % CO2. Fruits were analyzed at the end of a 3- day treatment and after transfer to air for one additional day. Unfavorablestorageconditionswereassociatedwithadecrease in the levels of bound water and in that of 1-kestose and myo- inositol. However, the 1-kestose and myo-inositol content was enhancedwhen40%CO2-treatedstrawberriesweretransferred toairatthesametimeasanincreaseinbound watercontentand a restoration of intracellular water took place. The ability of the fruit to modulate the accumulation of these compounds, and by extension their water binding strength, in conjunction with the pool of the bound water fraction, appears to be a mechanism associated with the maintenance of cellular structural integrity. Variation in the percentage of air space and in the weight loss rate produced by enhancing the CO2 treatment during storage at 0 °C was also analyzed.
Metrological Analysis of Sunflower Prototype

It is well known that the solar tracking systems can increase the efficiency of the photovoltaic (PV) panel by about 30 percent. However, these systems require precise control of their components, mainly of the equipment’s used for the measurement of energy. In this paper, a metrology analysis is conducted, through of the results obtained by Sunflower prototype. The Sunflower is a solar tracking system developed by H. J. Loschi. A tracking system through a microcontrolled timing logic, sending commands to a linear actuator that moves the system. The deductions, based on in research trials, confirms that the Sunflower prototype is more efficient in relation to fixed PV panels, it is possible to observe the difference in the efficiency of 31%, with a variation of ±0.8% (that depends the solar irradiation). The main purpose of this paper is to attest to the quality of the measurements carried out during the performance tests of the Sunflower prototype, evaluating the uncertainty of measurements collected through the measurements equipment, and, introducing methods to minimize uncertainties of measurement equipment in the PV systems.