SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Use of sleep medications and risk of cancer: a matched case–control study

Previous research suggests a possible link between sleep-medication use and mortality, especially cancer deaths, but findings are mixed, and large population-based studies are lacking.Data from the Finnish Public Sector study were linked to the Finnish Cancer Register and the Drug Prescription Register of Finland. A total of 5053 cancer cases (mean age of 57.4 years) diagnosed in 2002-2011, and their 24,388 controls free of cancer and matched for sex, age, socioeconomic status, employer, and geographical area, were identified. The use of sleep medications was defined as purchases of prescribed sleep medications.Both quantity and duration of prior sleep-medication use during the seven years studied were associated with increased odds of having cancer. Compared with participants not using sleep medications, the odds ratio was 1.18-fold (95% confidence interval (CI): 1.01-1.39) for those who used >100 defined daily doses per year and 1.16-fold (95% CI: 1.01-1.34) for those who had such a medication for >3 years. Site-specific analyses showed a more pronounced association of quantity and duration of sleep-medication use with subsequent cancer of the respiratory system (odds ratio for >100 defined daily doses per year vs. no use: 3.47; 95% CI: 1.97-6.11). No associations were found with other cancer sites.In this register-based study, sleep-medication use was associated with an increased cancer incidence of the respiratory system. Further studies are needed to examine potential carcinogenic mechanisms associated with hypnotic medications.
Search for two body muon decay signals

Lepton family number violation is tested by searching for $\mu^+\to e^+X^0$ decays among the 5.8$\times 10^8$ positive muon decay events analyzed by the TWIST collaboration. Limits are set on the production of both massless and massive $X^0$ bosons. The large angular acceptance of this experiment allows limits to be placed on anisotropic $\mu^+\to e^+X^0$ decays, which can arise from interactions violating both lepton flavor and parity conservation. Branching ratio limits of order $10^{-5}$ are obtained for bosons with masses of 13 - 80 MeV/c$^2$ and with different decay asymmetries. For bosons with masses less than 13 MeV/c$^{2}$ the asymmetry dependence is much stronger and the 90% limit on the branching ratio varies up to $5.8 \times 10^{-5}$. This is the first study that explicitly evaluates the limits for anisotropic two body muon decays.
Apparatus for the evaluation of polynomials

Evaluation of multi-dimensional high order polynomials at high speed requires complex computing resources. This invention comprises a computing apparatus which allows the efficient and high speed calculation of such polynomials with a relatively simple computing resource. The computing resource consists entirely of adders and latches. There are no multipliers. The invention has particular application for the removal of low frequency image distortion due to kinetic heating in IR imaging missiles.
Combatting disorders of adaptive immunity with systems medicine

Background: EU countries face large health challenges to combat chronic diseases. Recently, systems medicine has emerged as a promising discipline to accelerate the translation of basic research into applications for improved diagnostics and personalized treatment. Its power arises from the integration of laboratory and computational approaches crossing research disciplines and sectors to solve clinical questions. COSMIC delivers the next generation of leading, entrepreneurial, and innovative systems medicine professionals having expertise, skills, and experience to successfully combat complex human disorders. These professional will find excellent career opportunities. COSMIC focuses on B-cell neoplasia and rheumatoid arthritis, prototypical diseases originating from abnormal functioning of immune cells, often resulting in similar antigen specificities. COSMIC enables Early Stage Researchers to play a leading role in this exciting field.

Approach: COSMIC develops and integrate experimental and computational approaches and establish a unique cross-fertilization between oncology and auto-immunity. In addition to transferable skills, the training program focuses on establishing a double expertise in laboratory and computational to address clinical questions. It involves a wide-range of stakeholders: (pre)clinical departments, companies, patient groups, students, and the general public. COSMIC will establish a link with the leading European EASyM and ISBE initiatives, and aims to harmonize systems medicine training throughout Europe by connecting to other EU (Marie Curie systems medicine) training initiatives.

Impact: COSMIC (i) significantly improves ESR career perspectives (ii) leads to new public-private collaborations increasing competitiveness for companies; (iii) contributes to future oncology and immunology medical care; (iv) contributes to the EU systems medicine best practices.
The evolutionary ecology of bacterial immune mechanisms

Bacteria have a range of immune mechanisms, but it is unclear why this diverse armamentarium evolved. The most important immune mechanisms are (1) Surface Modification (SM) (2) Abortive infection (Abi) (3) Restriction Modification (R-M) (4) CRISPR-Cas and (5) prokaryotic Argonaute (pAgo), all of which can occur as stand-alone mechanisms or in combination. The individual mechanisms differ in key aspects, such as their fitness costs (constitutive versus inducible), specificity (indiscriminate versus specific), the recipient of the benefits (individual versus group), the speed of de novo resistance evolution (rapid versus slow), and heritability of immunity. Here I will take a combined in vitro and in vivo approach to tease apart the variables that drive the evolution of these diverse stand-alone and integrated bacterial immune strategies in nature, and examine their associated co-evolutionary dynamics. I focus on three ecological variables that are consistently important in host-symbiont co-evolution: (1) force of infection (2) spatial structure (3) presence of mutualists (plasmids). First, I will perform in vitro manipulations using Pseudomonas aeruginosa PA14 variants that carry either single or multiple immune mechanisms. Next, I will sequence metagenomes, transcriptomes and viromes of microbial communities from environments that differ in ecological variables that are important in vitro, to examine their importance in vivo. Key ecological mechanisms identified in the first two parts of the project will be used to guide mesocosm experiments to experimentally confirm that these mechanisms are the drivers of the observed patterns of resistance and co-evolution in nature. Finally, I will share my data with mathematical biologists to generate theoretical models to predict and manipulate the evolution of bacterial immune mechanisms, which will facilitate tailored species protection in agriculture and industry.
A mediator-free glucose biosensor based on glucose oxidase/chitosan/α-zirconium phosphate ternary biocomposite

A novel glucose oxidase/chitosan/α-zirconium phosphate (GOD/chitosan/α-ZrP) ternary biocomposite was prepared by co-intercalating glucose oxidase (GOD) and chitosan into the interlayers of α-zirconium phosphate (α-ZrP) via a delamination-reassembly procedure. The results of X-ray diffraction, infrared spectroscopy, circular dichroism, and ultraviolet spectrum characterizations indicated not only the layered and hybrid structure of the GOD/chitosan/α-ZrP ternary biocomposite but also the recovered activity of the intercalated GOD improved by the co-intercalated chitosan. By depositing the GOD/chitosan/α-ZrP biocomposite film onto a glassy carbon electrode, the direct electrochemistry of the intercalated GOD was achieved with a fast electron transfer rate constant, k(s), of 7.48±3.52 s(-1). Moreover, this GOD/chitosan/α-ZrP biocomposite modified electrode exhibited a sensitive response to glucose in the linear range of 0.25-8.0 mM (R=0.9994, n=14), with a determination limit of 0.076 mM.
Innovative technology for milk safety

The proposal is focused on the development of novel complex assay for evaluation of milk safety, which is important for dairy industry to assure required safety and quality of milk and dairy products. The complex biosensing assay will be focused on development of the methods for rapid and sensitive detection of bacterial pathogens and antibiotics that could occur in milk and represent potential hazard for health. Eight experienced academic/research institutions, two SMEs and one governmental business company from 3 EU member states (Slovakia, Hungary, Greece) and from 3 third countries (USA, Canada and Russia) will be involved in the research, development and verification of assays for detection of bacterial pathogens and antibiotics in milk. The focus will be on application of surface acoustic, electrochemical and optical methods using nanofabricated surfaces with immobilized DNA aptamers for detection of pathogenic bacteria and antibiotics. The output of the project will be the development of novel analytical assays, staff exchange between academic institutions and SME, training of the students in novel analytical methods, and sensor development in world leading laboratories. The important result of the project is optimized complex assay for efficient assessment of milk safety, which could be commercialised by the project industrial participants. The organization of training schools, workshops and transfer of novel technology will be among priorities of this proposal.
AN APPARATUS FOR CLEANING WORKSHOP PRODUCTS

An apparatus for cleaning printed circuit cards by means of alcohol is described. According to the invention the apparatus has a washing chamber (3) enclosed in a housing and a sluice disposed vertically above said washing chamber and being formed by a drying chamber (2) having an opening (7) closable by means of an outer hatch (8) to enable a basket (6) filled with printed circuit cards to be moved in and out of the drying chamber (2), and an opening (9) closable by means of an inner hatch (10) to enable a basket (6) to be moved down into and up out of the washing chamber containing a tank (14) with alcohol. Furthermore, the apparatus has a vertically displaceable support means (17) carrying a basket (6) in order to transport it between the drying chamber and the washing chamber for immersion of the basket into the alcohol, a pneumatic cylinder (24) being disposed externally on the housing and connected to the support means via a connection element (18) in order to effect the vertical displacement of the support means. An exhaust air channel system (33) is connected to the washing chamber and drying chamber to create a vacuum in the housing (1) for evacuation of the explosive alcohol from the chambers (2, 3). The hatches are controlled by a control means so that only one of the hatches can be opened at a time.
Revolving around the ubiquitin‒proteasome system: usp2-targeted degrader

Targeting DUB enzymes has recently emerged as a promising opportunity for drug discovery that might lead to more selective, less toxic drug profiles. Target validation of these enzymes is currently a priority in the field, as we are lacking of appropriate chemical probes for most of them. A clear example is USP2, whose chemical inhibition has been barely explored, leading to a poor-quality chemical probe that has been extensively used by biologist during the last decade. Hence, this multidisciplinary project emerges to address the identified unmet need of providing the scientific community with an appropriate chemical probe for a confident interrogation and further understanding of USP2 biology and disease. This probe will be useful for a suitable validation of this promising target and can eventually feed drug discovery projects for USP2-related cancer treatments.
Herein, we aim to develop a, USP2-Targeted Degrader (USP2-TD) that overcomes the lack of selectivity and potency of its parent counterpart. This small-molecule USP2-TD will enable investigations of selective USP2 downregulation with exquisite quantitative and temporal control of protein levels. To this end, the proposed research deal with the identification of solvent-exposed region at the parent, the discovery of the USP2-TD, and its validation as chemical probe for USP2.
Does it matter what you call it? A randomized trial of language used to describe palliative care services

Integration of palliative care into oncology practice remains suboptimal. Misperceptions about the meaning of palliative care may negatively impact utilization.We assessed whether the term and/or description of palliative care services affected patient views.2x2 between-subject randomized factorial telephone survey of 169 patients with advanced cancer. Patients were randomized into one of four groups that differed by name (supportive care vs. palliative care) and description (patient-centered vs. traditional). Main outcomes (0-10 Likert scale) were patient understanding, impressions, perceived need, and intended use of services.When compared to palliative care, the term supportive care was associated with better understanding (7.7 vs. 6.8; p = 0.021), more favorable impressions (8.4 vs. 7.3; p = 0.002), and higher future perceived need (8.6 vs. 7.7; p = 0.017). There was no difference in outcomes between traditional and patient-centered descriptions. In adjusted linear regression models, the term supportive care remained associated with more favorable impressions (p = 0.003) and higher future perceived need (p = 0.022) when compared to palliative care.Patients with advanced cancer view the name supportive care more favorably than palliative care. Future efforts to integrate principles of palliative medicine into oncology may require changing impressions of palliative care or substituting the term supportive care.
PROCESS OF COATING TACKY AND SOFT POLYMER PELLETS

An improved process of coating tacky or soft polymer pellets to maintain a free-flowing property, uses a liquid binder, in conjunction with an anti-tack or partitioning powder such as talc to prevent aggregation during storage. The binder is a non-volatile material such as an oil or plasticizer including triglycerides, mono-/di-glycerides, acetylated mono-/di-glycerides, fatty acids, epoxidized triglycerides, phthalates, benzoates, sebacates, lactates, citrates, mineral oils etc. Applications of this process include chewing gum bases, hot-melt adhesives, sealants, rubber masterbatches, powdered rubber, and other soft and tacky polymer materials.
Mango (Harum Manis) quality grading system

Weight and size are the major parameters that the consumer identifies to be related to the grade of mango. According to Federal Agricultural Marketing Authority (FAMA) Malaysia, size of a mango is determined by weight. The mango named “Harum Manis” is a famous agricultural product of Perlis, Malaysia. To date, the farmers still rely manually on their visual inspection and experience to grade the mangoes into three sizes, i.e. A, B and C, where A is the largest mango, B is the medium and C is the smallest. This method is not consistent and erroneous amongst the farmers due to varying experience and human errors. Moreover, it becomes costly when more workers are needed. This paper investigates this issue and demonstrates a mechatronic system to grade the mangoes by weighing. The user could read the grade from a display. This method provides a consistent and easy-to-use solution to the farmer.
PHARMACEUTICAL COMPOSITIONS OF IRON FOR ORAL ADMINISTRATION

The present invention generally relates to orally administered pharmaceutical compositions of iron compounds with medium chain fatty acid salts. The invention further relates to methods of using the pharmaceutical compositions to treat iron deficiency and related disorders.
The evolution of adaptive response mechanisms

In an era of rapid climate change there is a pressing need to understand whether and how organisms are able to adapt to novel environments. Such understanding is hampered by a major divide in the life sciences. Disciplines like systems biology or neurobiology make rapid progress in unravelling the mechanisms underlying the responses of organisms to their environment, but this knowledge is insufficiently integrated in eco-evolutionary theory. Current eco-evolutionary models focus on the response patterns themselves, largely neglecting the structures and mechanisms producing these patterns. Here I propose a new, mechanism-oriented framework that views the architecture of adaptation, rather than the resulting responses, as the primary target of natural selection. I am convinced that this change in perspective will yield fundamentally new insights, necessitating the re-evaluation of many seemingly well-established eco-evolutionary principles.

My aim is to develop a comprehensive theory of the eco-evolutionary causes and consequences of the architecture underlying adaptive responses. In three parallel lines of investigation, I will study how architecture is shaped by selection, how evolved response strategies reflect the underlying architecture, and how these responses affect the eco-evolutionary dynamics and the capacity to adapt to novel conditions. All three lines have the potential of making ground-breaking contributions to eco-evolutionary theory, including: the specification of evolutionary tipping points; resolving the puzzle that real organisms evolve much faster than predicted by current theory; a new and general explanation for the evolutionary emergence of individual variation; and a framework for studying the evolution of learning and other general-purpose mechanisms. By making use of concepts from information theory and artificial intelligence, the project will also introduce various methodological innovations.
Advanced cyber-threat intelligence, detection, and mitigation platform for a trusted internet of things

The CYBER-TRUST project aims to develop an innovative cyber-threat intelligence gathering, detection, and mitigation platform to tackle the grand challenges towards securing the ecosystem of IoT devices. The security problems arising from the flawed design of legacy hardware and embedded devices allows cyber-criminals to easily compromise them and launch large-scale attacks toward critical cyber-infrastructures. The proposed interdisciplinary approach will capture different phases of such emerging attacks, before and after known (even years old) or unknown (zero-day) vulnerabilities have been widely exploited by cyber-criminals to launch the attack. Emphasis is given on building a proactive cyber-threat intelligence gathering and sharing system to prevent the exploitation of zero-day vulnerabilities. This intelligence information will be used to maintain accurate vulnerability profiles of IoT devices, in accordance with data protection, privacy, or other regulations, and optimally alter their attack surface to minimise the damage from cyber-attacks. Novel technologies will be developed, based on distributed ledgers and blockchains, to monitor devices’ integrity state and network behaviour that will considerably increase the detection and response capabilities against targeted and interdisciplinary cyber-attacks. In the case of alleged malicious activity, tools for collecting and storing forensic evidence on a tamper-proof blockchain structure will be delivered, taking into account the specific needs of law enforcement agencies. Privacy-preserving network monitoring and advanced virtual reality-based visualisation techniques will be employed for quickly detecting botnets, DDoS attacks and other incidents. Relying on interdisciplinary research, an intelligent autonomous cyber-defence framework will be built for providing
intelligent ways of isolating the devices under an attacker’s control (or infected) and effectively responding to and mitigating large-scale attacks.
Re-discovering the ancient pilgrimages between Carinthia and Friuli Venezia Giulia - The art of hiking

The FVG and Carinthia are crossed by ancient pilgrimage routes which lead to Santiago, Rome and Jerusalem. The importance of these itineraries has not yet been valorised, a connection between these locations is missing, along with a sustainable package tours and an adequate cross-border signage system. The project stems from the idea of enhancing the value of these routes and their varied natural and cultural heritage, preserving its attractiveness and uniqueness by creating tourist itineraries as an alternative to mass tourism solutions. _x000D_
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Objective of this project is to safeguard and enhance the value of the natural and cultural heritage by creating a network to connect these routes in order to provide a new type of sustainable cross-border tourism offer accessible to everyone, even to disabled tourists; this involves the creation of integrated actions, services and information, cross-border package tours, the setting up of reception rooms and to improve accessibility to tourist destinations and places of cultural interest situated along the routes. _x000D_
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Dissemination activities: PR activities, brochures, leaflets, two events: in St. Veit and Colloredo. Impact: include the reduction of the territorial asymmetry of tourist attraction, by means of the enhancement of slow tourism and theme-based tourism packages with a higher added value, economic growth with the number of tourists who visit it as well as the number of sites of natural and cultural interest which have been visited.
aparelho extensível, cabeça de broca, e método

a presente invenção se refere a um aparelho extensível, em particular a um aparelho extensível para uma cabeça de broca. a presente invenção adicionalmente se refere a uma cabeça de broca compreendendo um aparelho extensível, e a um método de operação de uma cabeça de broca. em concordância com apresente invenção, o aparelho extensível (50) compreende uma seção de base (550) e uma seção de tração (560); uma seção de extensão (650) e uma seção funcional (660); a seção de base (550) e a seção de tração (560) sendo movíveis com respeito para a seção de extensão (650) e para a seção funcional (660) ao longo de um eixo geométrico longitudinal (la); a seção de tração (560) e a seção funcional (600) sendo rotativamente rígidas acopladas uma para a outra; a seção de base (550) e a seção de extensão (650) sendo rotativamente rígidas acopladas uma para a outra; a seção de tração (560) e a seção funcional (660) sendo rotativamente movíveis acopladas para a seção de extensão (650).
Improving the Access of SMEs from Rural Regions to the Knowledge and Information Society

The project "EMBRACE" aims to design, develop and implement specific spatial development policies, initiatives and actions for the benefit of SMEs located in rural and undeveloped urban areas. Their access to Knowledge and the Information Society should be increased. "EMBRACE" intends to establish a pilot virtual network, available both online and offline, where SMEs can have access to a wide range of business services and tools, such as consulting and training in key topics, matchmaking for accessing investor funds, e-commerce, etc. The goal is to overcome existing barriers that these SMEs face, by providing assistance and value-added advisory, e-commerce and information services, which can boost their efficiency and competitiveness, and lead to the development of transnational cooperation and globalisation of activities.