SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Intracellular trafficking of hybrid gene delivery vectors

Viral and non-viral gene delivery vectors are in development for human gene therapy, but both exhibit disadvantages such as inadequate efficiency, lack of cell-specific targeting or safety concerns. We have recently reported the design of hybrid delivery vectors combining retrovirus-like particles with synthetic polymers or lipids that are efficient, provide sustained gene expression and are more stable compared to native retroviruses. To guide further development of this promising class of gene delivery vectors, we have investigated their mechanisms of intracellular trafficking. Moloney murine leukemia virus-like particles (M-VLPs) were complexed with chitosan (Chi) or liposomes (Lip) comprising DOTAP, DOPE and cholesterol to form the hybrid vectors (Chi/M-VLPs and Lip/M-VLPs, respectively). Transfection efficiency and cellular internalization of the vectors were quantified in the presence of a panel of inhibitors of various endocytic pathways. Intracellular transport and trafficking kinetics of the hybrid vectors were dependent on the synthetic component and used a combination of clathrin- and caveolar-dependent endocytosis and macropinocytosis. Chi/M-VLPs were slower to transfect compared to Lip/M-VLPs due to the delayed detachment of the synthetic component. The synthetic component of hybrid gene delivery vectors plays a significant role in their cellular interactions and processing and is a key parameter for the design of more efficient gene delivery vehicles.
A qualidade do atendimento oferecido pelas Unidades de Pronto Atendimento (UPAS) do Brasil: uma revisão narrativa

Objetivo: Avaliar a qualidade de atendimentos prestados pelos prontos-socorros de Unidades de Pronto Atendimento (UPAS) do Brasil. Revisão Bibliográfica: As UPAs possuem regime de funcionamento contínuo, durante 24 horas por dia, e todos os dias da semana, e o objetivo primordial é a prestação de atendimento qualificado aos indivíduos que apresentam quadros agudos ou agudizados de cunho clínico, bem como o primeiro auxílio e atendimento aos pacientes com quadro clínico de natureza cirúrgica e trauma. A partir da leitura criteriosa dos textos selecionados, foi possível observar a qualidade de serviço em Unidades de Pronto Atendimento possui fragilidades logo no momento de entrada do usuário no serviço de urgência e emergência, que pode comprometer a segurança e o bem-estar do paciente que já se encontra em uma posição de condição de saúde vulnerável. Considerações finais: As deficiências encontradas dentro do serviço de urgência e emergência comprometem a efetividade e qualidade de prestação de serviço para com o paciente, na qual, pode levar à um aumento de sofrimento físico ou psicológico deste indivíduo, que já se encontra em um estado de vulnerabilidade clínica.
The Hypocholesterolemic Effect of Germinated Brown Rice Involves the Upregulation of the Apolipoprotein A1 and Low-Density Lipoprotein Receptor Genes

Germinated brown rice (GBR) is rich in bioactive compounds, which confer GBR with many functional properties. Evidence of its hypocholesterolemic effects is emerging, but the exact mechanisms of action and bioactive compounds involved have not been fully documented. Using type 2 diabetic rats, we studied the effects of white rice, GBR, and brown rice (BR) on lipid profile and on the regulation of selected genes involved in cholesterol metabolism. Our results showed that the upregulation of apolipoprotein A1 and low-density lipoprotein receptor genes was involved in the hypocholesterolemic effects of GBR. Additionally, in vitro studies using HEPG2 cells showed that acylated steryl glycoside, gamma amino butyric acid, and oryzanol and phenolic extracts of GBR contribute to the nutrigenomic regulation of these genes. Transcriptional and nontranscriptional mechanisms are likely involved in the overall hypocholesterolemic effects of GBR suggesting that it may have an impact on the prevention and/or management of hypercholesterolemia due to a wide variety of metabolic perturbations. However, there is need to conduct long-term clinical trials to determine the clinical relevance of the hypocholesterolemic effects of GBR determined through animal studies.
The State in India after Liberalization

Introduction: The State in India After Liberalization Akhil Gupta and K. Sivaramakrishnan Part 1: The Indian State as Moral and Political Economy 1. On the Enchantment of the State Sudipto Kaviraj 2. An Institutional Perspective on the Post-liberalization State in India Aseema Sinha Part 2: Citizens, Sociality, and Association 3. States of Empowerment Aradhana Sharma 4. 'New Politics' and the Governmentality of the Post-liberalization State in India: An Ethnographic Perspective John Harriss Part 3: Liberalization, the State, and the Experience of Poverty 5. Poverty Knowledge and Poverty Action in India Anirudh Krishna 6. 'Money Itself Discriminates': Obstetric Crises in the Time of Liberalization Patricia Jeffery and Roger Jeffery Part 4: Law, Identity, and Rights 7. Normative Vision, Cultural Accommodation and Muslim Law Reform in India Narendra Subramanian 8. The Rule of Law and the Rule of Property: Law-Struggles and the Neo-Liberal State in India Nandini Sundar Part 5: Enterprising Citizens 9. The Terms of Trade: Competition and Cooperation in Neoliberal North India Kriti Kapilla 10. Becoming Entrepreneurial Subjects: Neoliberalism and Media Purnima Mankekar
Perfil epidemiológico das notificações por malária no Nordeste do Brasil, entre 2015-2021

A malária é uma doença infecciosa febril, que possui como vetor a fêmea do mosquito Anopheles (mosquito prego) infectada por um protozoário, o Plasmodium. No Brasil, cerca de 99% dos casos estão concentrados na região amazônica, considerada área endêmica do país. Os casos identificados na região extra-amazônica são considerados como doença de notificação compulsória imediata. O trabalho tem como objetivo analisar o perfil epidemiológico da malária na região Nordeste. A metodologia utilizada foi um abordagem epidemiológica ecológica, com dados obtidos a partir do Sistema de Informação de Agravos de Notificação (SINAN), disponíveis no Departamento de Informática do Ministério da Saúde (DATASUS). Da região Nordeste, o estado com mais casos notificados de malária foi a Bahia (28,4%), seguido do Piauí (20,2%), durante o período compreendido entre os anos de 2015-2021. O ano de 2018 representou o período com o maior número de casos, com um total de 152 notificações. Em contrapartida, o ano de 2021 expôs o menor número de registros confirmados, com apenas 9. Por fim, é notória a ausência de controle na cadeia de transmissão da doença, sendo necessária uma melhor vigilância epidemiológica, associada a uma aplicação mais eficaz das políticas públicas preconizadas pelo Plano Nacional de Controle da Malária (PNCM), e um estímulo a mais estudos similares.
Secondary victims and the trauma of wrongful conviction: Families and children’s perspectives on imprisonment, release and adjustment

This paper examines the experiences of secondary victims of wrongful conviction, including the children of appellants and those families suffering bereavement following homicide. Most wives, mothers and children affected by miscarriages of justice continued to suffer from symptoms associated with post-traumatic stress disorder despite the appellant’s quashed conviction and release from the Court of Appeal (Criminal Division). In cases where the victim of crime (where alive) and defendant come from the same family the trauma experienced by the appellant and family can be catastrophic, leading to broken relationships and prolonged trauma. This paper will examine the consequences of families’ victimisation and consider those factors that contribute further to their pain. The article will conclude that most secondary victims continue to suffer from their traumatic experiences and that the children of appellants suffer particularly from the injustice of learning to cope with the wrongful conviction and imprisonment of a parent.
Wireless optical/radio terabit communications

5G promises increased connectivity, high data rates, and ultimately new services. The first 5G release standard in 3GPP will be available by June 2018 with pre-commercial deployment in Korea soon after. Whilst 5G will meet current demand, the exponential rise in demand for wireless connectivity will ultimately require Tbps connectivity in indoor spaces. The future network will use an all optical fibre core, and an ultra-high data rate wireless ‘bridge’ to the User.

WORTECS focuses on the goal of ultra-high data rate wireless. High-frequency mm-wave (in the band above 90 GHz) radio communications will be combined with optical wireless communications in the infrared and visible regions of the optical spectrum, using novel heterogeneous networking concepts. A compelling virtual reality application will be used to showcase the capability of the WORTECS network. The project will deliver two Proof-of-Concept demonstrations. An ultra-high density LiFi/Radio network providing multi-Gbps to virtual reality terminals will be developed, and an ultra-high data rate Proof-of-Concept capable of Tbps networking will also be targeted.

WORTECS brings together innovative, world leading LiFi SMEs Oledcomm (France) and PureLiFi (UK), Global telecommunications operator Orange (France) and research institutes BCOM (France) and IHP (Germany). These are joined by university research leaders in optical wireless communications from the University of Oxford (UK) and the University of Las Palmas (Spain). The consortium has the dual ambition of proposing new scientific solutions beyond 5G while transferring these technologies from research labs to industrial world. A successful project will both showcase technologies required to alleviate the radio spectrum crunch, and provide substantial benefits to EU citizens through the exploitation of results by WORTECS commercial partners.
A Novel Evaluation Method for Building Construction Project Based on Integrated Information Entropy with Reliability Theory

Selecting construction schemes of the building engineering project is a complex multiobjective optimization decision process, in which many indexes need to be selected to find the optimum scheme. Aiming at this problem, this paper selects cost, progress, quality, and safety as the four first-order evaluation indexes, uses the quantitative method for the cost index, uses integrated qualitative and quantitative methodologies for progress, quality, and safety indexes, and integrates engineering economics, reliability theories, and information entropy theory to present a new evaluation method for building construction project. Combined with a practical case, this paper also presents detailed computing processes and steps, including selecting all order indexes, establishing the index matrix, computing score values of all order indexes, computing the synthesis score, sorting all selected schemes, and making analysis and decision. Presented method can offer valuable references for risk computing of building construction projects.
CLEANING APPARATUS FOR A COMPONENT OF A HOUSEHOLD TUMBLE DRYER

The invention relates to a cleaning apparatus for a component (16) which is arranged within a process-air circuit of a household tumble dryer, in particular for a heat exchanger, having a cleaning brush (28) which is to be moved along the component (16) by means of a drive rod (32) of a drive mechanism, wherein the cleaning brush (28) is to be supplied with a cleaning fluid via a feed line (54).
Diagnosis of pulmonary and extrapulmonary tuberculosis based on detection of mycobacterial antigen 85B by immuno-PCR

We developed a novel indirect sandwich immuno-polymerase chain reaction (I-PCR) assay for the detection of mycobacterial antigen 85B (Ag85B, 30kDa, Rv1886c) in pulmonary tuberculosis (PTB) and extrapulmonary tuberculosis (EPTB) patients. The amino-modified reporter DNA was covalently attached with the antidetection antibody through a heterobifunctional cross-linking agent succinimidyl 4-[N-maleimidomethyl]-cyclohexane-1-carboxylate. The detection limit of Ag85B by I-PCR was found to be 1 femtogram (fg)/mL, which was 10(6)-fold lower than an analogous enzyme-linked immunosorbent assay (ELISA). The sensitivities of 85% and 77% with I-PCR and 77.6% and 62.5% with ELISA were observed in smear-positive and smear-negative PTB patients, respectively, with high specificity. On the other hand, sensitivities of 84% and 63.7% with I-PCR and 68% and 47.5% with ELISA were observed in confirmed and clinically suspected EPTB cases, respectively, with high specificity.
Introduction to the special issue on Japanese geminate obstruents

Geminate obstruents (GOs) and so-called unaccented words are the two properties most characteristic of Japanese phonology and the two features that are most difficult to learn for foreign learners of Japanese, regardless of their native language. This special issue deals with the first of these features, discussing what makes GOs so difficult to master, what is so special about them, and what makes the research thereon so interesting. GOs are one of the two types of geminate consonant in Japanese which roughly corresponds to what is called ‘sokuon’ (促音). ‘Sokon’ is defined as a ‘one-moralong silence’ (Sanseido Daijirin Dictionary), often symbolized as /Q/ in Japanese linguistics, and is transcribed with a small letter corresponding to /tu/ (っ or ッ) in Japanese orthography. Its presence or absence is distinctive in Japanese phonology as exemplified by many pairs of words, including the following (dots /. / indicate syllable boundaries).
Tür-oder Fensterprofil

Tür- oder Fensterprofil (1), mit einer oder mehr aneinanderliegenden Holzschichten (3, 5, 7), wobei zwischen den zwei Holzschichten (3, 5; 5, 7) und/oder außen an wenigstens einer Holzschicht ein Stützband (4, 6, 8, 9) mit Kontaktflächen zu der oder den jeweils anliegenden Holzschichten angeordnet ist, dadurch gekennzeichnet, dass das Stützband aus Carbon ausgebildet ist.
Geothermal energy to address energy performance strategies in residential and industrial buildings

Geothermal Energy (the energy extracted from heat stored in the earth) is one of the most environmental-friendly and cost-effective energy resources in use and has the potential to help mitigate global warming if widely deployed in place of fossil fuel. Recent technological progress, the variability of the cost, the difficult of oil and gas supply, the need to reduce the use of fossil fuels to cut pollution have made the exploitation of geothermal energy, especially low-enthalpy power generation utilizing GCHP (Ground Coupled Heat Pumps) an attractive and viable alternative. Give these premises, the general objective of GEO.POWER project, 2 years long, is exchange best practices related to low enthalpy energy supply and - after a technical and cost/benefit assessment to evaluate the potential of reproducibility - to prepare the ground to the transfer some of the selected best practices within the Mainstreaming Programmes of the regions participating into the project
during the current programming period 07-13 as well as in the future regional framework instruments.
The main results of the project are the development of one action plan per each involved region, that provides an organized set of legal/regulatory, economical and technical / technical and best-technological proposals that–through the inclusion into the regional operation programmes, address long-term investments strategy for GCHP application at wide scale. The partnership, coordinated by the Province of Ferrara (Italy) is composed by Ministries, Regions, Local Authorities, Universities and R&D agencies of 8 Countries (Bulgaria, Hungary, Greece, Italy, Sweden, Estonia, UK and Belgium) that are dealing–at different level-with the attainment of  European policy objectives in relation to 20/20/20 Kyoto targets and the EU Building Performance Directive. The partnership benefits of a strong technical background, as it capitalize experiences coming from the major EU projects
in the field of low enthalpy geothermal & technological applications, like  Ground-Reach, GROUNDHIT, Ground-Med and LOW-BIN.On the basis of a pool of best practices on GCHP application developed in urban, rural and industrial sector, all partners and local delegation of experts & stakeholders go through an evaluation of the best practices reproducibility potential in each recipients region, according to technical, economical and environmental parameters, in order to design the optimum performance conditions for GCHP systems and the capacity to fit with the territorial context. The consequent preparation of the action plans and its inclusion into the Regional Operational Programmes cold represent a milestone for the future introduction of massive GCHP investments in the concerned regions. A strong communication strategy aims at increasing awareness, improving knowledge & better understanding of the GCHP merit and benefits and push investments towards such green-economy
Betriebsmittelzuschuss für Media Sp. z o.o.

Das Projekt betrifft die Unterstützung des Unternehmers bei der Bereitstellung finanzieller Liquidität und die Unterstützung laufender Tätigkeiten aufgrund finanzieller Schwierigkeiten, die der Unternehmer infolge des COVID-19-Ausbruchs erlebt hat. Finanzielle Unterstützung im Rahmen des Programms SA.57015 (2020/N)
A Study on Demand Response Potential of a Residential Area Using Census Data

Demand response (DR) allows consumers to adapt their power usage at peak hours such that it is financially beneficial for them as well as induces lesser stress for the electric grid, paving the way for a greener future with less energy wastage. However, the daily routines of the average electricity consumer might prohibit the active participation in the demand response program. In this work the power profiles of different types of electricity users (more than million users in total) are built using census data and user interview results and a sample demand response program is simulated. To build the profiles, data from different types of customers in different household types and different income states are used. The demand response potential of each of the customer type is then analyzed and identified. A direct control service provider based demand response program is used to simulate the power usage under demand response. Cooperative Particle Swarm Optimization (CPSO) algorithm running on a high performance GPU cluster is employed to calculate the optimum power usage of the million customer profiles generated.
Galileo-Based solutions for urban freight transport

Urban Freight Transport action relates to find solutions to better manage and monitor freight transport flows and ensure efficient last-mile delivery, while maximizing the economic efficiency of urban distribution, and minimizing the environmental and social impacts. GALENA develops the hardware equipment as well as the information system and the supervision platform needed for the cross supply chain orchestration of a community of shippers involved in urban freight pooling particularly for the last-mile delivery. GALENA relies on the development of a robust and GNSS-based liability binding application, enabling the different carrier operators to join a Mutualized Transportation Community to timestamp, geo-locate and formalize (as a real authentication) their trip as well as any events occurring during the shipping. An innovative, accurate and affordable hybrid system (Galileo/RTLS) will be developed for this purpose ensuring a seamless, robust and continuous handover indoor/outdoor localization and continuous, real-time, reliable, accurate and available Position, Velocity and Time (PVT) of carriers and high value parcels. An already existing logistics information systems will be adapted to exchange and store shipment authenticated data between all stakeholders, ensuring the traceability of goods, management of status changes while drawing up an objective review of the sharing of added value between the various stakeholders of a shared supply chain. A web service application will be set up for continuously supervising transactions and support to the orchestration decision making process. A truly interdisciplinary collaboration between GNSS, wireless sensors, logistics information systems, urban logistics and freight transport experts is set up to meet the objectives. The consortium gathers 8 EU partners committed within 2-year project to disseminate results towards potential customers and confirm the conditions for a successful larger scale deployment.
The emergence of a science of vegetation in early modern natural philosophy and the sciences of life: from cesalpino to malpighi

This three-year research project aims to explore the emergence of a philosophy and science of plants in the century that goes from Cesalpino’s De plantis (1583) to Malpighi’s Anatome plantarum (1679), which influenced the development of a new science of life. Although understudied, a new approach to the study of plants and vegetation surfaces in this period, bridging the gulf between natural historical efforts to classify plants and natural philosophical investigations of vegetal bodies. By means of overlooked sources, the main objective of this project is to reconstruct these philosophical examinations through 4 sub-objectives: (1) the appropriation and reinterpretation of Aristotelian biology in botany; (2) the development of alchemical and mechanical frameworks to understand vegetal life; (3) the definition of plants as a crucial subject to reinterpret the physiology of living bodies; (4) the collecting attraction to plants diversity, and monstrosity, which preludes to the philosophical perception of interconnected systems of life, forestalling biodiversity. While new scholarly attention has been recently devoted to the philosophical study of plants in the early modern period, the result of this research project will be a broad investigation into the concept of vegetation and vegetal life that paved the way to eighteenth century morphologies and systems of nature. This project will result into several articles and a scholarly book for historians of knowledge.
Dr Baldassarri has international experience in Germany, the Netherlands, Romania, and Israel, and has focused on the Cartesian understanding of plants and the mechanization of the vegetative soul. The development of this project will profoundly impact his career: training provided by Ca’ Foscari University in Venice and Bloomington Indiana University will help Baldassarri acquire new academic skills and boost his knowledge in connecting early modern science to contemporary biology and vegetal philosophy.