SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
A journey from Topolo to Abitanti

This project is going to reproduce in Abitanti the successful experiences of Topolo, that is to say planning the village renovation and enliven the cultural life of the village. For the last ten years, in summer, Topolo has hosted the event “Stazione Topolo”, which has seen the participation of international artists. This event has set up a thick network of contacts with centres and towns all over the world, in order to enhance the rural village. Over the last decade, thanks to the active contribution provided by the EU funds, some houses have been renovated, and Topolo has become an attractive tourist destination. Topolo and Abitanti have several elements in common: they are close to the border between two countries: the former is close to the border between Italy and Slovenia, the latter between Slovenia and Croatia. Both of them have been affected by a harsh crisis: Topolo after the Second World War, and Abitanti over the last twenty years. Both of them have responded by enlivening their villages through cultural activities (“Stazione Topolo” and the spring painters’ colony in Abitanti). The project is carried out through several stages: Abitanti hosts a workshop on the renovation and enlivening of the Slovenian village; Topolo, in turn, plays host to the post-production of the material gathered during the workshop and to the planning of the web site; meeting with a group of Slovenian architects and presentation of the material gathered in Abitanti; publishing of a “travel journal”, which collects the experiences of the Slovenian and Italian participants (a CD is enclosed); “Stazione Topolo” hosts the representatives of Abitanti cultural associations and the joint exhibition “Immages from Abitanti and Topolo”.
European guideline (<scp>EuroGuiDerm</scp>) on atopic eczema – part <scp>II</scp>: non‐systemic treatments and treatment recommendations for special <scp>AE</scp> patient populations

The evidence- and consensus-based guideline on atopic eczema was developed in accordance with the EuroGuiDerm Guideline and Consensus Statement Development Manual. Four consensus conferences were held between December 2020 and July 2021. Twenty-nine experts (including clinicians and patient representatives) from 12 European countries participated. This second part of the guideline includes recommendations and detailed information on basic therapy with emollients and moisturizers, topical anti-inflammatory treatment, antimicrobial and antipruritic treatment and UV phototherapy. Furthermore, this part of the guideline covers techniques for avoiding provocation factors, as well as dietary interventions, immunotherapy, complementary medicine and educational interventions for patients with atopic eczema and deals with occupational and psychodermatological aspects of the disease. It also contains guidance on treatment for paediatric and adolescent patients and pregnant or breastfeeding women, as well as considerations for patients who want to have a child. A chapter on the patient perspective is also provided. The first part of the guideline, published separately, contains recommendations and guidance on systemic treatment with conventional immunosuppressive drugs, biologics and janus kinase (JAK) inhibitors, as well as information on the scope and purpose of the guideline, and a section on guideline methodology.
Deciphering central role of vmh circuits in regulating energy balance

Incidence of obesity has been steadily increasing for the last few decades. A corresponding rise in the obesity associated co-morbidities such as cardiovascular diseases and type-2 diabetes makes it an acute priority to understand the mechanisms underlying body weight regulation. It is well established that distributed brain circuits tightly monitor and regulate energy stores. Of particular interest, electrical and pharmacological manipulations to ventromedial portion of the hypothalamus (VMH), results in dramatic alterations in food intake, adiposity and glucose homeostasis in animal models. Furthermore, human genetic screens have shown that, at least for a subset of morbidly obese patients, genes that are heavily expressed in VMH are altered. Collectively these observations point to a central role for VMH in driving negative energy balance, yet relatively little is known how VMH neurons achieve this. To identify novel mechanisms for controlling energy balance, we propose to determine the following: 1) identify signals that regulate VMH neuronal activity, this includes synaptic input as well as circulating signals, 2) dissect out immediate downstream and upstream synaptic targets of VMH neurons mediating food intake and glucose homeostasis. To achieve this, we will use state of the art neuronal circuit mapping techniques involving virus based retrograde tracers and optogenetics. By combining functional electrophysiology and morphological approaches we will determine brain regions that has connections to and from VMH and evaluate behavioral and physiological significance each of these connections in-vivo. Understanding the basics of the functional VMH-wiring diagram will help determine how these neuronal circuits change under the conditions of metabolic and feeding disorders and will provide basis of targeted approaches for treatment.
A new predictive control technique for force control of pneumatic actuator plant

A new predictive control technique has been proposed in this article. The proposed strategy is based on the control matrix formulation combined with a tuning technique using model regression. Poor dynamics and high nonlinearities are parts of the difficulties in the control of pneumatic actuator functions, which make the proposed matrix an attractive solution. The proposed regression technique expression of the move suppression λ Ργ is applied with the proposed matrix to achieve the best result. The performance of the designed controller achieved impressive results for its quick response and accurate behavior of the tracking compared to the conventional method. The developed controller is applied to a pneumatic actuator to optimize the force and to reduce the impact of measurement noise of the system to achieve better and smoother tracking.
Percepción del riesgo al desempleo en México. Un estudio cuantitativo

El riesgo conforma un elemento tácito en la biografía de los agentes en sociedades contemporáneas, pero en el campo del trabajo esta situación es significativamente más perceptible.Para el caso mexicano esta situación es imperantes porque más de la mitad de la actividad económica se ubica en la informalidad, el restante en empleos estables pero contenidos de precariedad y flexibilidad, más el desempleo abierto.Tal panorama influye en los estados subjetivos a través de preocupación por perder su fuente de ingreso en el futuro inmediato.El objetivo es examinar el riesgo laboral del periodo 1995 -2018, además de determinar qué situación personal y laboral generan tal percepción.Lo anterior se analiza con la encuesta Latinobarómetro 2018 a partir de una variable que indaga el temor a ser despedido; esto con un procedimiento cuantitativo transversal y otro multifactorial ordinal.Los resultados indican predominancia de riesgo laboral en la mayoría de periodos analizados que repuntan en etapas de crisis o recesiones económicas y quienes perciben mayor riesgo laboral son sectores en desventajas como jóvenes en edades productivas de clases bajas con menor formación escolar, con responsabilidades familiares y cuyas condiciones laborales son asalariadas o en informalidad.
Novel and functional variants within the TBX18 gene promoter in ventricular septal defects

Congenital heart disease (CHD) is the most common birth defect in humans. Genetic causes for CHD remain largely unknown. T-box transcription factor 18 (TBX18) gene is expressed in the developing heart, including myocardium of the left ventricle and interventricular septum. Epicardial cells expressing TBX18 gene contribute to the cardiac fibroblast and smooth muscle cells. We speculated that the DNA sequence variants (DSVs) within TBX18 gene promoter may mediate CHD development by affecting TBX18 levels and the cardiac gene regulatory network. In this study, we genetically and functionally analyzed the TBX18 gene promoter in patients with ventricular septal defects (VSD) (n = 326) and ethnic-matched healthy controls (n = 327). Three novel heterozygous DSVs (g.85474435del, g.85474418C>T, and g.85473965C>G) and one single nucleotide polymorphism (g.85474871C>T, rs77693245) were identified in VSD patients, but none in the controls. Functional analysis revealed that the DSVs (g.85474871C>T, g.85474435del, and g.85473965C>G) significantly decreased the transcriptional activities of the TBX18 gene promoter. The effect of DSV (g.85474418C>T) on the TBX18 gene promoter was marginal, but not significant. Therefore, the DSVs within the TBX18 gene promoter identified in VSD patients may be involved in the VSD etiology.
X-RAY RADIATION SOURCE, COLLIMATOR, RADIOLOGICAL WORKSTATION AND METHOD FOR OPERATING SAME

The present invention relates to an X-ray radiation source, a collimator (50), a radiological workstation and a method for operating same. According to the invention, a beam shaping diaphragm (57) is provided comprising at least one diaphragm pair, the diaphragm elements (67a, 67b, 67c, 67d) of which are adjustable asymmetrically with respect to a central ray of the X-ray tube. As a result, the X-ray radiation source can be used more flexibly and/or with reduced radiation loading.
Modernidade e Tradição: Os traços arquitectónicos na Avenida Ressano Garcia no período entre 1904 a 1909

O objectivo deste artigo é o de salientar as principais características de um conjunto de edifícios construídos de 1904 a 1909 na Avenida Ressano Garcia em Lisboa, a partir do projecto do arquitecto Raul Lino para Joaquim de Jesus Ferreira. Neste projecto o arquitecto enveredou por uma linguagem arquitectónica sóbria, com referências quinhentistas e abordagens novas, inspiradas na arquitectura tradicional portuguesa e na contemporânea anglo-saxónica. Este projeto foi caso único e não teve repercussão no trabalho de outros projetistas e até 1909 foram erigidos edifícios de diferentes tipologias, onde se exploraram conceitos novos. O presente artigo partiu do cotejamento de várias fontes arquivísticas e bibliografia, para salientar a intemporalidade da obra aqui selecionada e que caracteriza, em parte, a arquitectura do início do século XX em Portugal.
Land Capability Classification of Ollukara Block Panchayat Using GIS

Abstract Ollukara Block Panchayat in Thrissur district, which has depletion of ground water level, is selected for the study. Land is classified into land capability classes as per IS 6748(Part-1) for the purpose of watershed management. The result shows that the area comprises of five capability classes, II, III, IV, VI and VII. In these classes, class VI and VII are not suitable for agriculture. Class II, III, and IV are suitable for agriculture. Class III comprises 28.35% of the area. The area is presently under semi critical zone based on ground water level. Proper care should be given to the study area in terms of watershed management, since the area is only marginally away from over exploited category.
Characterisation of a green microenvironment and to study its impact upon health and well-being in the elderly as a way forward for health tourism.

Our society in Europe is still under prepared for the demographic changing situation of an ageing population which began several decades ago. This is visible in the age structure of the population and is reflected by the fact that the population aged 65 years and over is increasing in every European country. The growth in the elderly population may be explained by increased longevity, but at the same time, we also see an increase in debilitating conditions. However, it is also clear that the elderly are afflicted by challenging health conditions as a direct consequence of being elderly which impact their quality of life (QOL), e.g. living alone, depression, recovery from illness, immobility. This is what we would like to address. Living longer should be a privilege but there has been a collective failure to address social implications and QOL issues, where social care and the way it is funded are already in crisis. Our aim in this project is to couple the need for new societal approaches in addressing this changing demographic with improving the economy of green microenvironment sites, where health tourism and creating new jobs in this sector would in turn fund and provide benefits with respect to the well-being of the elderly. The ultimate outcome, through this pan-European academic and industrial project, will be: a) to derive cross-disciplinary and inter-sectorial knowledge of how to improve physical and mental well-being in the elderly, b) to characterise the environmental geology of Nemi and to correlate the identified features with improvements in health, well-being and recovery, c) to train a new generation of specialists in the sector of recreation and health for the tourism industry, d) the training of specialists in social and therapeutic horticulture (STH) as a way to improve physical and mental health, e) to create a model for health tourism, and f) to produce a business plan with an economic impact analysis.
MMI-based all-optical multi-input XOR and XNOR logic gates using nonlinear directional coupler

We propose an all-optical 2-input XOR logic gate based on multimode interference and employ it as a basic structure in order to develop 3- and 4-input XOR logic gates. A 3 dB MMI coupler has been designed to be used as 2-input XOR logic gate. The integration of optical 2-input XOR gates encounters with the phase matching issues. Therefore, a nonlinear directional coupler is associated to produce a relative phase shift of π between the coupled and uncoupled branches. Such phase shift is cancelled with launching a simultaneous high intensity control field. Also, by assigning logic 1 to one of inputs in n-input XOR structure, the (n − 1)-input XNOR logic gate has been achieved. Two dimensional beam propagation method has been used to simulate and verify the performance of proposed all-optical 2-, 3- and 4-input XOR logic gates. Simulation results show that the proposed structure is almost insensitive to fabrication process tolerances.
Identification of income-leisure preferences and evaluation of income tax policy

The merits of alternative income tax policies depend on the population distribution of preferences for income and leisure. Standard theory, which supposes that persons want more income and more leisure, does not predict how they resolve the tension between these desires. Empirical studies of labor supply have imposed strong preference assumptions that lack foundation. This paper examines anew the problem of inference on incomeleisure preferences and considers the implications for evaluation of tax policy. I first perform a basic revealed-preference analysis assuming only that persons prefer more income and leisure. This shows that observation of a person's time allocation under a status quo tax policy may bound his allocation under a proposed policy or may have no implications, depending on the tax schedules and the person's status quo time allocation. I next explore the identifying power of two classes of assumptions that restrict the distribution of incomeleisure preferences. One assumes that groups of persons who face different choice sets have the same preference distribution. The second restricts the shape of this distribution. The generic finding is partial identification of preferences. This implies partial prediction of tax revenue under proposed policies and partial knowledge of the welfare function for utilitarian policy evaluation. Keywords. Revealed preference analysis, partial identification, labor supply. JEL classification. C14, C25, H21, H24, J22.
Nanoparticle formation after nanosecond-laser irradiation of thin gold films

Evolution in nanoparticle formation was observed after nanosecond-laser irradiation of thin gold films on a silicon substrate and physical phenomena leading to the formation of nanoparticles were studied. Gold films of different thickness (3, 5, 10, 15, 20, and 25 nm) were evaporated on the silicon (110) substrate and irradiated with the pulsed nanosecond laser using different pulse energies and the number of pulses in a burst. Experimentally morphological changes appeared in the films only when the pulse energy was high enough to initiate the phase transition. The threshold energy density for phase transitions in the films was estimated from the thermal model of the laser beam and sample interaction. With the pulse energy just above the threshold, it was possible to observe evolution of nanoparticle formation from a plane metal film by changing the number of pulses applied, as duration of the pulse burst represented the time how long the liquid phase existed. The final size of nanoparticles was a functio...
Incidence and Influence of Hospitalization for Recurrent Syncope and Its Effect on Short- and Long-Term All-Cause and Cardiovascular Mortality

Recurrence of syncope is a common event, but the influence of recurrent syncope on the risk of death has not previously been investigated on a large scale. We examined the prognostic impact of recurrent syncope in a nationwide cohort of patients with syncope. All patients (n = 70,819) hospitalized from 2001 to 2009 in Denmark with a first-time diagnosis of syncope aged from 15 to 90 years were identified from national registries. Recurrence of syncope was incorporated as a time-dependent variable in multivariable-adjusted Cox models on the outcomes of 30-day, 1-year, and long-term all-cause mortality and cardiovascular death. During a mean follow-up of 3.9 ± 2.6 years, a total of 11,621 patients (16.4%) had at least 1 hospitalization for recurrent syncope, with a median time to recurrence of 251 days (33 to 364). A total of 14,270 patients died, and 3,204 deaths were preceded by a hospitalization for recurrent syncope. The long-term risk of all-cause death was significantly associated with recurrent syncope (hazard ratio 2.64, 95% confidence interval 2.54 to 2.75) compared with those with no recurrence. On 1-year mortality, recurrent syncope was associated with a 3.2-fold increase in risk and on 30-day mortality associated with a threefold increase. The increased mortality risk was consistent over age groups 15 to 39, 40 to 59, and 60 to 89 years, and a similar pattern of increase in both long-term and short-term risk of cardiovascular death was evident. In conclusion, recurrent syncope is independently associated with all-cause and cardiovascular mortality across all age groups exhibiting a high prognostic influence. Increased awareness on high short- and long-term risk of adverse events in subjects with recurrent syncope is warranted for future risk stratification.
An efficient pair natural orbital based configuration interaction scheme for the calculation of open-shell ionization potentials

A spin adapted configuration interaction scheme is proposed for the evaluation of ionization potentials in α high spin open shell reference functions. There are three different ways to remove an electron from such a reference, including the removal of an alpha or a beta electron from doubly occupied or an alpha electron from singly occupied molecular orbitals. Ionization operators are constructed for each of these cases, and the resulting second quantized expressions are implemented using an automated code generator environment. To achieve greater computational efficiency, the virtual space is reduced using an averaged pair natural orbital machinery developed earlier and applied with great success in the calculation of X-ray absorption spectra [D. Manganas et al., J. Chem. Phys. A 122, 1215 (2018)]. Various approximate integral evaluation schemes including the resolution of identity and seminumerical techniques are also invoked to further enhance the computational efficiency. Although the resulting method is not particularly accurate in terms of predicting absolute energy values, with a simple shift in the ionization potentials, it is still possible to use it for the qualitative characterization of the basic features of X-ray photoionization spectra. While satellite intensities cannot be computed with the current method, the inclusion of vibrational effects using a path integral technique allows for the computation of vibrational transitions corresponding to main peaks.
Commercialisation of dental medical device for measuring salivary ph

Oral hygiene is very important for health and well-being of humans. The global market of home dental hygiene products is more than 30 billion USD world-wide, with an estimated increase of 8% annually (CAGR). Several recent studies have proved that salivary pH is a diagnostic biomarker of oral and even some gastroenterological diseases. The deviation of salivary pH from the normal value of 7.2 indicates pathological status. However, the self-measurement of salivary pH is very difficult, even impossible, since no device is commercialised for this purpose. Salivary pH is now usually measured from spittle using pH indicator paper (lacmus). This measurement is not accurate enough, and difficult to carry out by patients at home. We have developed and designed an easy-to use medical device for measuring the salivary pH in the mouth. The new device is revolutionary ergonomic, have data storage and transfer capabilities, connection to smart devices, accurate (0.1 pH), ball-pan-sized and accessible for visually impaired (Braille writing). We have protected the design and participated in several start-up events, where we won different local awards. Medika device is ground-breaking, creating new market, as it will be the first self-measurement device for measuring salivary pH at home. It will help dentists to measure and record the pH of saliva for large number of patients routinely and remotely before and after dental surgery. Its use by the wide public will prevent or avoid worsening of several oral and gastroenterological diseases. The aim of this phase 1 project is to make a feasibility study for both the technical and business development actions planned for the commercialisation of Medika device: to specify the software and the prototype, to prepare for clinical validation, to refine our business plan and to prepare the project plan for an SME Instrument Phase 2 application.
A Tailorable Infrastructure to Enhance Mobile Seamless Learning

The widespread use of mobile devices is leading towards their adoption in the learning process, even if some pedagogical challenges are still not fully addressed when integrating mobile-assisted activities into regular curricula activities. In this paper, we first define some guidelines to design a general, tailorable, and platform-independent mobile learning system. Second, we present the aCME system, a mobile infrastructure, developed by adhering to the defined guidelines, to provide a general-purpose system, easy to start up with and friendly to user, and finally, tailorable, i.e., that can be easily adapted to the needs of different learning environments. The aCME system has been implemented as a Web-based architecture, to provide content and functionalities for different contexts, accessible from any location and by using any communication device. Finally, we describe a tool, deployed into aCME, that allows responding to quiz-based questionnaires during learning activities. A preliminary evaluation was performed to analyze usability and user satisfaction when interacting with the system we developed. The paper is concluded with some comments and future research directions.