SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Pathologic Aggregates Of Small Nuclear Ribonucleoproteins (snRNP) Are Present In Familial Alzheimer's Disease (P1.244)

Objective: To understand small nuclear ribonucleoprotein (snRNP) biochemical and pathologic features in familial AD.
Background: We recently identified U1 small nuclear ribonucleoprotein (snRNP) aggregates in sporadic Alzheimer’s disease (AD). We also found evidence for RNA processing dysfunction in AD. Little is known about snRNP changes in familial AD.
Design/Methods: We performed quantitative proteomics and immunohistochemistry in postmortem brain from familial AD cases including presenilin-1 and amyloid precursor protein mutation carriers as well as Down9s syndrome cases. We also utilized electron microscopy to characterize ultrastructural characteristics of pathologic aggregates. Finally, we performed similar studies in a transgenic mouse with amyloid precursor protein and presenilin-1 (APP/PS-1) mutations to understand species specificity.
Results: We saw biochemical enrichment of U1-70k and other snRNPs in the human familial AD insoluble fraction. We also visualized snRNP cytoplasmic tangle-like aggregates and snRNP immunogold labeling of paired helical filaments. Interestingly, APP/PS-1 transgenic mouse brain demonstrated normal snRNP localization and no shift in snRNP solubility. We also saw variability in the enrichment of other proteins when comparing human familial AD and the APP/PS-1 transgenic mouse proteomes as well as many similarly affected pathways.
Conclusions: These studies identify U1-snRNP pathologic changes in familial AD as seen previously in sporadic AD and suggest that the novel pathologic findings are influenced by aberrant amyloid processing. Other cellular changes, like tau aggregation, may also be necessary since the APP/PS1 mouse did not have snRNP pathology. The comparison of human familial AD and rodent transgenic APP/PS1 proteomes highlights challenges with using this model to recapitulate human disease and study snRNP changes in particular. Disclosure: Dr. Hales has nothing to disclose. Dr. Dammer has nothing to disclose. Dr. Duong has nothing to disclose. Dr. Yi has nothing to disclose. Dr. Gearing has nothing to disclose. Dr. Levey has received personal compensation for activities with GenoMind. Dr. Levey has received research support from Janssen Pharmaceutica, Merck & Co. Inc., Ceregene, and Medivation. Dr. Lah has received research support from Elan Corp., Medivation, Merck & Co. Inc., and Ceregene. Dr. Seyfried has nothing to disclose.
Evaluation of ablation of thyroid remnants with 1850 MBq iodine-131 in 67 patients with thyroid cancer

Radioiodine remnant ablation (RRA) is used to destroy residual normal thyroid tissue after total thyroidectomy in differentiated thyroid carcinoma (DTC) patients. As 1850-MBq RRA is routinely performed at our facility, we evaluated the outcomes.Sixty-seven DTC patients without macroscopic residual lesions after total thyroidectomy were evaluated. Thyroglobulin (Tg) was measured 2-3 months before RRA with thyroxin administration (pretreatment); just before ablation after a 3-week iodine intake restriction with thyroxin withdrawal (THW) (N.=16) or recombinant human thyroid-stimulating hormone (rhTSH) stimulation (N.=51); and 3 months after RRA, after a 2-week iodine intake restriction and 3-week THW (N.=57) or rhTSH stimulation (N.=10). All patients received 131I (1850 MBq) treatment followed by 131I scintigraphy about 8 days later (8.18±0.91) and 131I scintigraphy (185 MBq) after the dosage 24 hours later 3months after RRA. Initial RRA goal was defined as negatively visible uptake in 131I thyroid bed (VUT) and a Tg level of <2 ng/mL 3 months after RRA.Rest 60 patients whose TSH levels were below 0.5 µIU/mL of all 67 patients were evaluated. Negatively VUT on 3 months after RRA was shown in 56 out of 60 patients (93.3%). Initial RRA goal was achieved in 21 (42.0%) of 50 patients, excluding 3 patients whose Tg levels 3 months after RRA were not measured and 7 patients with anti-Tg antibodies. Pretreatment Tg levels (P=0.0003) was significant predictive factor for Initial RRA goal on multivariate logistic regression analysis.RRA with 1850 MBq is effective by visual diagnosis, about 40% of all intermediate or high-risk DTC patients achieved initial RRA goals by both visual and Tg levels diagnosis.
Paleomagnetism and chronology of B-1 marginal sills of the Bushveld Complex from the eastern Kaapvaal Craton, South Africa

AbstractThe Rustenburg Layered Suite (RLS) of the Bushveld Complex in South Africa is the largest mafic–ultramafic-layered complex on Earth. The RLS is associated with marginal sills that penetrate into the ~2.2 billion-year-old sedimentary strata of the Pretoria Group. These sills are in contact and share some geochemical similarities with different zones of RLS and are classified in terms of chemical composition, which suggests their derivation from distinct parental magma compositions (so-called B-1, B-2 and B-3 parental magmas). Existing paleomagnetic constraints for the Bushveld Complex originate from the upper Critical to Upper zones of the RLS, which are associated with B-2 and B-3 marginal sills. Geochemically, verified B-1 marginal intrusions are here used as a proxy for constraining the paleomagnetism and chronology of the Lower and lower Critical zones of the RLS. We identified a dual-polarity magnetic component with a paleopole (Latitude = 13.1°N, Longitude = 44.0°E, A95 = 14.3, N = 7) that is...
Sustainable and Innovative European Biogas Environment


Europe's current dependencies on imports of natural gas (and the willingness to delivery from its supplier states) have proven to be at valuable risk during recent years. When considering the projections of our growing energy demand during the next decades in relation to Europe's natural oil and gas resources it becomes clear that these dependencies will have tremendous pricing effects on our economies in the near future.

Decentralized energy production from renewable resources - both, through the usage of biogas as fuel originator and as basic resource for feeding into the available gas grids - hold great and currently underdeveloped potential to reduce these dependencies and further foster Europe's leadership position within this key areas of innovation. The availability of established regional gas grids in connection with new biogas -, biogas cleaning technologies and -methodologies are key elements of combining current infrastructure with new application fields to  further improve profitability of current biogas plants.

Therefore, the SEBE project aims at a coordinated further development of biogas utilization, technology and transnational competence knowledge center within the CENTRAL EUROPE programme area. Different operating environments (legal, economical and logistical, technical), shortages on qualified and specialized human resources (planning, operation, support and maintenance) as well as several regional factors (e.g. available resources, logistics, or failed biogas plants from past projects) throughout the member states in the CE area form a challenging environment to work in.
The Small Investors in Rental Property: A Socioeconomic and Financial Analysis

The small investors in rental real estate in Spain have grown more than 50% over a decade. In this paper, we investigate who are those small investors in rental real estate, to know their demographic and financial characteristics. We do that through bivariate statistics and a logistic model. We find that there are several characteristics related to the decision to invest in real estate such as the age of householders, education, marital and health status, and homeownership. This paper gives new insights regarding the behavior of small investors and why they invest.
BELTRAMI LINEN SRL RESUME 2021

PURPOSE ÃÂ Â: DIGITAL TRANSITION OBJECTIVES: — INTEGRATING DIGITAL TECHNOLOGIES INTO PRODUCTION PROCESSES: FUNCTIONAL INTERVENTIONS FOR THE INTEGRATION OF DIGITAL TECHNOLOGIES IN THE PRODUCTION CYCLE OF THE COMPANY’S GOAL ÃÂ Â: GREEN TRANSITION OBJECTIVES: — INCREASE THE ENERGY EFFICIENCY OF THE PRODUCTION SYSTEM: FUNCTIONAL INTERVENTIONS TO REDUCE ENERGY CONSUMPTION OR IN ANY CASE TO LOW ENERGY CONSUMPTION, TO RATIONALISE ENERGY FLOWS AND MINIMISE ANY ENERGY WASTE, TO RECOVER OR ENHANCE DISPERSED ENERGY
Urothelial carcinoma biomarker based diagnostic test

Bladder cancer is among the five most common malignancies worldwide: more than 380.000 new cases are diagnosed yearly. If detected early, 5-year survival is high (94%),but >70% of diagnosed patients will relapse within this period. 
The current gold standard diagnostic tool is combined cytology and cystoscopy which is costly and highly invasive requiring transurethral access and presenting the risk of important complications. Due to high relapse rates, surveillance requires frequent cystoscopies, averaging 13 controls per patient after initial diagnosis. Hence, bladder cancer is one of the costliest cancers to treat and monitor. Only in the USA, Europe and Japan, more than 4.5 million cystoscopies are conducted yearly, 40% for 1st diagnosis and 60% for surveillance, at a cost near to $2 billion to healthcare providers.
Urologists believe that an opportunity exists to reduce the number of SURVEILLANCE cystoscopies with a reliable, cost-effective, robust, easy-to-perfom and non-invasive assay. 
URO-BEST addresses this unmet need. Based on signatures of 2, 5,10 and 12 differentially-expressed genes, this test has been clinically validated in a multicenter international study on 525 urine samples demonstrating 81% sensitivity and 91% specificity in discriminating cases vs. healhty patients for first diagnosis, figures comparable to that of the gold standard and superior to other existing molecular diagnostic products (Urovysion, NMP22, BTA Stat). We estimate the current market for bladder cancer biomarker based tests at greater than > $200million. 
Fina Biotech has filed European and PCT patent applications protecting the invention in 2013.
Fina Biotech aims to clinically validate the diagnostic performance of the genetic signatures in patients under SURVEILLANCE for its launch to the market: advance ongoing discussions with potential partners for global licensing,increase urologists awareness and secure freedom to operate.
Urbanization in china's south-western borderlands. the case of jinghong, xiguangbanna

This interdisciplinary research project aims to study urbanization in China’s non-metropolitan and non-industrial ethnic-diverse border regions under post-socialism. Literature on urbanization in China focuses mainly on traditional large metropolitan or industrial cities in the center with Han majority population, and examines either the structural or the subjective features of urban development. The complex dynamics of urbanization and power relations in the new cities in the periphery remain understudied. The project fills this knowledge gap, by exploring how urbanization intersects with tourism growth and in-migration and affects ethnic relations in Jinghong, a fast-growing city in China’s south-western borderlands. In Jinghong, the Han, China’s ethnic majority, have become the city’s drivers of urban and economic development, competing over land, resources and political power with long-term Dai/Tai minority ethnic residents. Unconventionally drawing on methods of Anthropology, Urban Planning, Architecture, Urban Geography, and Sociology, this pioneering project aims at producing a theoretically and empirically innovative analysis that combines structural, socio-economic, and political examination with an investigation of subjective and experiential aspects of urbanization, highlighting conflicts, mindsets, and prejudices in the day-to-day urban interactions between Han majority and ethnic minority citizens and the state. 

I expect that the development of this project will profoundly impact my career. Thanks to training provided by the Department of Architecture, Design and Urban Planning, at the University of Sassari, Italy’s utmost interdisciplinary institution of Architecture and Urban Planning, I will acquire new skills and build fruitful relations with European institutions and scholars. The training, network and publications of the project’s outcome will allow me to increase my possibilities of obtaining an ERC Grant.
Structural and Optical Modifications in Polyvinyl Alcohol Due to Cr2 O3 Nanoparticles Additives Concentration, and Gamma Irradiation

Nanosized chromium oxide Cr2O3 was prepared and mixed with polyvinyl alcohol (PVA) to produce nanocomposite films. X-ray diffraction (XRD) and transmission electron microscopy were performed to study the crystallinity and size of nano-Cr2O3. Based on the results, the average particle size of the Cr2O3 was found to be 29 nm. The effects of nanosized chromium oxide Cr2O3 concentration and gamma dose on the structural and optical properties of PVA have been studied. The resultant effect of Cr2O3 concentration on the properties of PVA has been investigated using XRD and UV spectroscopy. The results reveal that the addition of Cr2O3 to PVA up to 0.80% leads to a more compact structure of PVA, resulted in an improvement in the isotropic nature of the polymer samples due to the increase in the refractive index. In addition, the effect of gamma irradiation on the 0.50% Cr2O3/PVA nanocomposite has been investigated. Samples from the 0.50% Cr2O3 nanocomposite were irradiated with gamma doses in the range 200–1 kGy. It is found that the irradiation in the dose range 200–800 Gy causes cross-linking that increases the amorphous regions and gives polymer resilience.
Rigid foam and associated article

A polyurethane or polyisocyanurate foam is prepared from a reaction mixture that includes comprising a polyol, an aromatic isocyanate compound, and a blowing agent. The polyol includes a poly(phenylene ether) having a number average molecular weight of 600 to 2000 atomic mass units and an average of 1.5 to 3 hydroxyl groups per molecule. The polyurethane or polyisocyanurate foam exhibits improved resistance to burning and/or reduced elapsed times to formation of tack-free foams relative to foams prepared without the poly(phenylene ether).
C9Orf72-Mediated neurodegeneration: mechanisms and therapeutics

An expanded GGGGCC repeat in a non-coding region of the C9orf72 gene is the most common known cause of frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS). The repeat RNA is transcribed and accumulates in neuronal RNA aggregates, implicating RNA toxicity as a key pathogenic mechanism. However, the pathways that lead to neurodegeneration are unknown. My lab has made pioneering contributions to the understanding of C9orf72 FTD/ALS, and reported the first structure of the repeat RNA, and the first description of both sense and antisense RNA aggregates in patient brain. We have now developed new disease models that allow, for the first time, the dissection of RNA toxicity both in vivo and in sophisticated neuronal culture models. We have also used our knowledge of the repeat structure to identify novel small molecules that show very strong binding to the repeats. We will utilise our innovative disease models in a multidisciplinary approach to fully dissect the cellular pathways underlying C9orf72 repeat RNA toxicity in vivo, on a genome-wide scale. Altered RNA metabolism has been implicated in a wide range of neurodegenerative diseases, indicating that our findings will provide profound new insight into fundamental mechanisms of neuronal maintenance and survival. This research programme will also deliver a step change in our understanding of C9orf72 FTD/ALS pathogenesis and provide essential insight for the identification of small molecules with genuine therapeutic potential. RNA-mediated mechanisms are now known to be a common theme in neurodegeneration, suggesting these findings will have broad significance.
Novel cyclocarbon-porphyrin systems: synthesis and properties

The proposed project combines recent advancements in supramolecular porphyrin systems and polyyne chemistry to create and study novel hybrid compounds: carbo-porphyrin nanorings. This will include extensive synthetic work to find the most efficient working schemes for macrocyclic compounds with varying sizes and different peripheral substituents, while minimizing linear polymerization. Specific choice of the building blocks will be guided by computer-aided design to ensure appropriate connectivity and steric demands for subsequent cyclooligomerizations. The size selectivity will be further refined by using template-assisted covalent self-assembly utilizing differently coordinating templates. The electronic and magnetic nature of the target compounds will be studied in solution using a range of techniques, including Nuclear Magnetic Resonance spectroscopy, UV-vis-NIR absorption and fluorescence spectroscopy and electrochemical methods, additionally characterized with X-ray crystallography in the solid state. These efforts will be focused on exploring global aromatic and antiaromatic currents in the neutral and oxidized forms of the macrocycles, gaining insight into the nature of aromaticity in nanometer-size pi-conjugated systems and contributing to the design of future functional materials.
SOFTWARE DE ANÁLISIS DE LABORATORIO DE INNOVACIÓN TECNOLÓGICA PARA PERMITIR LA TRAZABILIDAD DE LAS OBRAS

SOFTWARE DE ANÁLISIS DE LABORATORIO DE INNOVACIÓN TECNOLÓGICA PARA PERMITIR LA TRAZABILIDAD DE LAS OPERACIONES REALIZADAS
Accuracy of ICD Codes for Persons with Considerable Emergency Department Use for Mental Health Complaints

The International Classification of Diseases (ICD) is the standard diagnostic tool for clinical, health management, and research purposes, put forth by the World Health Organization. Currently in its 10th version, ICD-11 is expected to release in 2017. Researchers use ICD codes to identify participants for clinical studies and to track healthcare utilization rates, among a variety of other purposes (e.g. to study access, quality, costs, and effectiveness of care, patient comorbidities, incidence of complications, morbidity, and mortality) (O’Malley et al., 2005). Clearly, code accuracy is paramount and existing priorities include assessing diagnostic congruence of ICD codes and medical records (De Coster et al., 2006). From the emerging evidence, we see that at least two ICD codes are needed to accurately identify individuals with confirmed chronic conditions (Goldberg et al., 2013). Yet, researchers continue to use single ICD codes to identify study participants (Krueger et al., 2011).
Principles of neural stem cell lineage progression in cerebral cortex development

The cerebral cortex consists of an extraordinary number and great diversity of neurons. Yet, how the cortical entity, with all its functional neuronal circuits, arises from the neural stem cells (NSCs) in the developing neuroepithelium is a major unsolved question in Neuroscience. Radial glia progenitors (RGPs) are responsible for producing nearly all neocortical neurons and a certain fraction of cortical glia including astrocytes. Our recent efforts provide evidence for a high degree of non-stochasticity and thus deterministic nature of RGP behavior in the mammalian neocortex. However, the cellular and molecular mechanisms controlling RGP lineage progression through proliferation, neurogenesis and especially gliogenesis are unknown. In a pursuit to obtain definitive insights into these fundamental questions we assess RGP lineage progression at the unprecedented single cell resolution, using the unique genetic MADM (Mosaic Analysis with Double Markers) technology. MADM offers an unparalleled approach to visualize and concomitantly manipulate sparse clones and small subsets of genetically defined neurons. Within the scope of this project we will use multidisciplinary experimental approaches to establish a research program with the following major objectives: We will 1) Functionally dissect the relative contribution of cell-autonomous intrinsic signaling and cell-non-autonomous effects in RGP lineage progression; 2) Define the principles of lineage progression in human RGPs in situ using MADM technology in cerebral organoid system; 3) Decipher the logic of glia lineage progression in the neocortex. The ultimate goal of the proposed research is to establish a definitive quantitative framework and mechanistic model of lineage progression in cortical NSCs. As such, the proposed research shall precipitate into extensive conceptual progress regarding the fundamental cellular and molecular principles of cerebral cortex development.
SELF-WATERING PLANT CONTAINER AND RELATED METHODS

A plant container includes a container body having a conduit extending between an inlet connection and an outlet connection. A float valve assembly is in communication with the conduit within the container body for automatically controlling fluid entry into the container body from the conduit. A soil retention element is arranged in the container body above the float valve assembly. A method of using the self-watering plant container includes adding soil to an interior volume of the container body above the soil retention element, planting at least one seed in the soil, and connecting a water supply to an inlet connection of the conduit.
Interferometeranordnung und Verfahren zu deren Betrieb

Die vorliegende Erfindung betrifft eine Interferometeranordnung und ein Verfahren zu deren Betrieb. Die Interferometeranordnung umfasst ein Interferometer mit einer Interferometer-Lichtquelle, deren emittierte Strahlung in einen Mess- und einen Referenzarm aufteilbar ist, wobei ein Messobjekt im Messarm angeordnet ist und das Interferometer von der Position des Messobjekts abhängige Interferometersignale liefert. Ferner sind Erfassungsmittel zur Erfassung von Fluktuationen des Brechungsindexes der Luft im Mess- und/oder Referenzarm vorgesehen. Hierbei umfassen die Erfassungsmittel eine Spektrometereinheit; die Spektrometereinheit weist mindestens eine Spektrometer-Lichtquelle sowie mindestens eine Spektrometer-Detektoreinheit auf. Die von der Spektrometer-Lichtquelle emittierten Strahlenbündel werden den Strahlenbündeln der Interferometer-Lichtquelle überlagert, wobei die Spektrometer-Lichtquelle Strahlung mit einer Wellenlänge emittiert, die im Bereich einer Absorptionslinie mindestens eines bestimmten Luftbestandteils liegt. Die Spektrometer-Detektoreinheit dient zur Erzeugung von Spektrometersignalen, die die Absorption des Luftbestandteils bzgl. der Spektrometer-Lichtquellenwellenlänge im Mess- und/oder Referenzarm charakterisieren (Figur 2a).
Gendering constitutional change and policy outcomes: substantive representation and domestic violence policy in Scotland

Scotland bears many hallmarks of a case of successful feminist constitutional activism: high levels of women’s descriptive representation in the devolved parliament and a gender-inclusive institutional design mutually reinforced one another, opening up the political process. In this article domestic violence policy is examined in order to address the question as to whether political devolution has led to positive gender outcomes, in respect of substantive gains for women. The actors, institutions and outcomes of Scottish initiatives (1998–2007) are traced and it is argued that policies have been distinctive in the UK with respect to timing, framing and approach. Domestic violence, therefore, provides a striking case where devolution ‘has made a difference’ to the substantive representation of women, with positive – albeit fragile – outcomes.