SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
OrthoMaM v8: A Database of Orthologous Exons and Coding Sequences for Comparative Genomics in Mammals

Comparative genomic studies extensively rely on alignments of orthologous sequences. Yet, selecting, gathering, and aligning orthologous exons and protein-coding sequences (CDS) that are relevant for a given evolutionary analysis can be a difficult and time-consuming task. In this context, we developed OrthoMaM, a database of ORTHOlogous MAmmalian Markers describing the evolutionary dynamics of orthologous genes in mammalian genomes using a phylogenetic framework. Since its first release in 2007, OrthoMaM has regularly evolved, not only to include newly available genomes but also to incorporate up-to-date software in its analytic pipeline. This eighth release integrates the 40 complete mammalian genomes available in Ensembl v73 and provides alignments, phylogenies, evolutionary descriptor information, and functional annotations for 13,404 single-copy orthologous CDS and 6,953 long exons. The graphical interface allows to easily explore OrthoMaM to identify markers with specific characteristics (e.g., taxa availability, alignment size, %G+C, evolutionary rate, chromosome location). It hence provides an efficient solution to sample preprocessed markers adapted to user-specific needs. OrthoMaM has proven to be a valuable resource for researchers interested in mammalian phylogenomics, evolutionary genomics, and has served as a source of benchmark empirical data sets in several methodological studies. OrthoMaM is available for browsing, query and complete or filtered downloads at http://www.orthomam.univ-montp2.fr/.
ISLAMIC ENTREPRENEURSHIP: A CASE STUDY OF SAUDI ARABIA

As this paper examines the relationship between Islamic values and entrepreneurial activity, it seeks to establish whether these values can be more effectively tapped into to raise the profile of Islamic form of entrepreneurship. A written, self-administered questionnaire among a random sample of Saudi entrepreneurs in the city of Riyadh was employed to generate descriptive data to assess the views and attitudes of Saudi entrepreneurs toward both conventional and Islamic forms of entrepreneurship. We find that Saudi entrepreneurs perceive themselves to be committed Muslims who consider entrepreneurship a religious and economic duty intended to generate halal (lawful) income to meet their financial obligations and to contribute to the falah (well-being) of the Muslim ummah (nation) in this life and hereafter. The findings also negate the prevalent conventional assumption that Islam is intrinsically anti-modernization and anti-development, and that the religiously-based Saudi culture would hinder the emergence and the development of a vibrant entrepreneurship culture in Saudi Arabia.
Bon ADVANCED STAGE~*individuel* S.R.L.~AFFIANCAMENT

LA CONTRIBUTION DE VERRÃEUR UTILISÉE POUR L’ACCOMPAGNEMENT DES CONSULTANTS DANS L’IDENTIFICATION DE NOUVEAUX PARTENAIRES INDUSTRIALICOMMERCIALI ET DANS L’ACQUISITION DE NOUVEAUX CLIENTS. EN PARTICULIER, NOUS OPERÃEUR POUR L’IDENTIFICATION D’UN NOUVEL OBJECTIF SUR LES MARCHÉS ÉTRANGERS, AINSI QUE POUR LA DÉFINITION DE NOUVEAUX ACCORDS DE COLLABORATION AVEC DES PARTENAIRES INTERNATIONAUX
Scaffold hybridization approach targeting ppis

Protein-protein interactions (PPIs) control all cellular processes relevant to health and disease, hence an outstanding challenge in chemical biology is to develop generic approaches for PPI inhibition. Such inhibitors (or chemical probes) represent unique tools to understand biological processes and starting points for drug discovery, for treatment of multiple illnesses for which effective treatments don’t currently exist e.g. cancer. 

SHAPPI will allow Zsofia Hegedus (the fellow) to join the laboratory of Andrew Wilson (host supervisor) at the University of Leeds (Host) and develop research expertise in the area of inhibiting protein-protein interactions. In doing so, she will (a) enhance her prospects to become an independent academic group leader and (b) address the need to train researchers in this key area of chemical biology and (c) develop cutting edge methods that advance peptidomimetic approaches for inhibition of protein-protein interactions. Scaffold hybridization will allow the combination of molecular scaffolds capable of hot spot mimicry with molecules that influence selectivity or potency. In combination with reversible chemistry this will allow generation of dynamic combinatorial libraries of rapid identification of selective and potent inhibitors. The fellowship will explore proteomimetic-peptide conjugates and peptide-small molecule dynamic combinatorial libraries to accelerate development of selective PPI inhibitors using two model interactions; HIF-1α/p300 and BID/BAX, both of which represent important targets for anticancer therapy.
STABILISED ZIRCONIA AND A PROCESS FOR THE PREPARATION THEREOF

1342406 Zirconia refractory MAGNESIUM ELEKTRON Ltd 28 June 1972 [29 June 1971] 30399/71 Heading C1J A stabilized zirconia body is made by mixing zirconia and a yttria concentrate containing 35 to 70% yttria and the remainder rare earth metal oxides, and having been prepared from a naturally occurring mineral containing yttrium and rare earth metals without isolation of pure yttria, the concentrate being present in an amount to provide at least 3 mol. per cent of yttria plus heavy rare earth (Atomic Nos. 62-71) oxides. The mixture is then calcined from 1 to 10 hours at 900 to 1500 C. The yttria concentrate is preferably dissolved in HCl and added to an aqueous slurry of basic zirconia sulphate, alkali added and the resulting hydroxides washed, dired and calcined. In the examples the following rare earths were present in addition to yttria: La, Ce, Pr, Nd, Sm, Eu, Gd, Tb, Dy, Ho, Er, Yb, Th.
Babyminder: automatic diagnosis of neurocognitive impairment in infants

Each year, millions of infants are born with neurodevelopment disorders resulting in cognitive deficits. Although infants are tested for their low-level (visual and auditory) abilities in the health care system, no standard tools exist for evaluating the development of cognitive functions, due to the absence of verbal report and explicit behaviour. Converging evidence now suggests that neural markers obtained from electroencephalographic (EEG) offer a valid approach for tracking the development of cognitive functions in the infant brain. The BabyMinder provides a proof-of-concept for a novel EEG portable system combined with a sensory stimulation application to track normal and impaired neurocognitive processing in infants. Its main purpose will be to help the diagnosis of neurodevelopmental disorders. The BabyMinder will be fully embedded in a wearable system and will feature active electrodes, which provide reliable EEG signals, yet do not require any electrolyte gel or humidification. Although several low-cost and fully portable systems have recently been developed for adults, none of these portable systems has been adapted to infant populations. It will also consist of a functional localizer for the automatic tracking of neurocognitive components. This functional localizer will consist of a stimulation protocol with various types of stimuli presented every few seconds, tapping specific levels of representation while the EEG device will monitor the deployment of dedicated neurocognitive components in real-time. The whole procedure will be embedded in children-friendly animations to keep infants interested. In time, a large database of participants will be collected and combined with state-of-the-art machine learning algorithms using a big data approach, improving the classification of normal vs. impaired neurocognitive processes. We aim to make the BabyMinder a standard tool for the diagnosis of neurodevelopmental disorders in the future.
Long-s in Late Modern English manuscripts

It is a generally accepted fact that the use of long- s , or &lt;ſ&gt;, was discontinued in English printing at the close of the eighteenth century and that by the end of the first quarter of the nineteenth century this allograph had all but disappeared. This demise of &lt;ſ&gt; in printing has been fairly well documented, but there is virtually no literature on what happened to it in handwritten documents. The disappearance of &lt;ſ&gt; and &lt;ſs&gt; (as in ʃeems and buʃineʃs ) in favour of &lt;s&gt; and &lt;ss&gt; is generally ascribed to the printers’ wishes to simplify their type-settings. But at what point and to what extent did this simplifying process influence private writing of the period? In this article we have documented the rules, as observed by printers, for the use of long- s in the Late Modern English period, and we illustrate how printing practice during this period compared to the usage of this particular grapheme in letters written by two well-known codifiers of the English language, the grammarians Joseph Priestley and Lindley Murray.
Small Mediterranean Insular Light Industries Enhancement and Support

The development of innovative manufacturing activities and processes in MED Islands can improve their innovation capacities, the diversification of their economy, the qualifications of the jobs offered and has a multiplier effect on all economic activities, while it contributes to a more sustainable use of key natural resources, notably water and energy. However insularity, scarcity of some resources and the need for compatibility with existing activities are constraints for exploiting this potential. SMILIES proposes to apply the “Trans-local Innovation System” concept which links innovation and internationalisation policies to boost regional competitiveness to develop a governance model for MED islands’ industrial innovation development. SMILIES will organise focused actions in concrete cases on the field, from which sustainable policies for islands’ industrial innovation will be defined. The SMILIES workplan follows a 30- month phased schedule, including a pilot phase. Pilot projects’ profiles will be selected after a contextual analysis of 6 opportunity scenarios of use of industrial innovation (to benefit from Tourism, Retail, Agro or Building activities, global niche markets or poorly- served local needs). End results are context and impact analysis tools for setting priorities of MED-Islands industrial innovation regional policies and a sustainable infrastructure and tools to support innovation transfer to entrepreneurs in projects that fit such policies.
Handbook of Digital Politics

To talk about the internet as a civic space requires some preliminary conceptualization; thus, first I briefly discuss two models of democracy – elitist and republican – to show that the ideals of civic participation can vary considerably. This is illuminated by a discussion of the role of the net in electoral and alternative politics. From there I approach civic space through two key concepts: civil society and the public sphere. I underscore the analytic importance of power relations in understanding the extent and character of participation (and exclusion). Thereafter I turn to research findings and debates on internet and political participation, looking at the arguments of ‘enthusiasts’ and ‘sceptics’. I claim that it is essential to grasp the various contingencies, manifested as dynamic configurations, that impact on how the internet is used. In this regard the political economy, as well as the technical architecture of the net, loom large. In socio-cultural terms, the net has become a historically new habitus for political participation. Lastly, I offer the framework of civic cultures as a way of empirically and critically analysing concrete situations of the internet as a civic space. The chapter concludes with some proposals for future research. (Less)
Lancement de la production de nouveaux équipements dans Marex Technology grâce à la mise en œuvre des résultats de R & D

L’objectif principal du projet sera d’introduire deux innovations de produits sur le marché en mettant en œuvre les résultats des propres travaux de R & D de la requérante, qui ont abouti à la notification de ces produits: Presse à vis et FLOKULATOR DYNAMIC pour la protection par brevet. Le Floculator est conçu pour effectuer le processus d’agrégation des polluants. D’autre part, la presse à vis sert à drainer les boues d’épuration. Les deux dispositifs sont utilisés dans les usines de traitement des eaux usées. En 2016, au cours des travaux de R & D, la requérante a construit les premiers prototypes des dispositifs. La mise en œuvre des résultats des travaux de R & D se fera par l’exécution de travaux de construction liés à l’adaptation du hall de production existant, à l’achat et à l’installation d’immobilisations couvrant des éléments du processus de production, et à l’achat d’ordinateurs et de logiciels pour soutenir le processus de production. Sur la base de l’installation de production cible, le processus technologique développé dans le cadre du projet de R & D sera optimisé. Les immobilisations acquises et les ressources humaines détenues par la requérante permettront à l’entreprise de commencer à produire les deux produits ci-dessus à l’échelle industrielle. Les destinataires des nouveaux produits seront des entreprises industrielles qui traiteront les eaux usées avant qu’elles ne soient rejetées dans le réseau d’égouts et les entrepreneurs de la station d’épuration, y compris les eaux urbaines résiduaires avant les émissions dans l’environnement, dans le cadre du processus d’élimination. Le projet a identifié 4 tâches correspondant aux objectifs spécifiques et aux étapes de mise en œuvre: 1. Soutien à la mise en œuvre du processus d’investissement (y compris les travaux préparatoires et les actions accompagnant la mise en œuvre), 2. Travaux de rénovation et d’adaptation liés à la préparation du hall de production, 3. Achat d’éléments de la ligne technologique nécessaire à la mise en œuvre des innovations de produits, 4. Mise en œuvre d’activités d’appui à la mise en œuvre et à l’amélioration de l’efficacité du processus de production (y compris l’utilisation des TIC et le processus d’appui fonctionnel aux contractants de travaux)
A Review of Existing Studies Reporting the Negative Effects of Alcohol Access and Positive Effects of Alcohol Control Policies on Interpersonal Violence

Alcohol consumption often leads to elevated rates of violence yet alcohol access policies continue to relax across the globe. Our review establishes the extent alcohol policy can moderate violent crime through alcohol availability restrictions. Results were informed from comprehensive selection of peer-reviewed journals from 1950 to October 2015. Our search identified 87 relevant studies on alcohol access and violence conducted across 12 countries. Seventeen studies included quasi-control design, and 23 conducted intervention analysis. Seventy-one (82%) reported a significant relationship between alcohol access and violent offenses. Alcohol outlet studies reported the greatest percentage of significant results (93%), with trading hours (63%), and alcohol price following (58%). Results from baseline studies indicated the effectiveness of increasing the price of commonly consumed alcohol, restricting the hours of alcohol trading, and limiting the number of alcohol outlets per region to prevent violent offenses. Unclear are the effects of tax reductions, restriction of on-premises re-entry, and different outlet types on violent crime. Further, the generalization of statistics over broad areas and the low number of control/intervention studies poses some concern for confounding or correlated effects on study results, and amount of information for local-level prevention of interpersonal violence. Future studies should focus on gathering longitudinal data, validating models, limiting crime data to peak drinking days and times, and wherever possible collecting the joint distribution between violent crime, intoxication, and place. A greater uptake of local-level analysis will benefit studies comparing the influence of multiple alcohol establishment types by relating the location of a crime to establishment proximity. Despite, some uncertainties particular studies showed that even modest policy changes, such as 1% increases in alcohol price, 1 h changes to closing times, and limiting establishment densities to <25 outlets per postal code substantively reduce violent crime.
POLLUTION  MONITORING  OF  SHIP  EMISSIONS:  AN  INTEGRATED  APPROACH FOR HARBOURS OF THE ADRIATIC BASIN

Harbours are important hubs for economic growth in both tourism and commercial activities. They are also an environmental burden being a source of atmospheric pollution often localized near cities and industrial complexes. The POSEIDON project investigates the impact on air quality of four major harbours in the Adriatic/Ionian Seas, using a common state-of-the-art methodology based on emission inventories, numerical modelling and experimental results that will produce comparable information useful to plan future actions and controls of emissions in the Adriatic/Ionian macroregion.
Polymeric nanoparticles with tunable architecture formed by biocompatible star shaped block copolymer

Abstract An amphiphilic star shaped block copolymer, based on well known biocompatible components, was synthesized using branched poly(e-caprolactone) as hydrophobic core and branched poly(ethyleneglycol) as hydrophilic corona. The composition of this macromolecule, based on two well differentiated blocks, conferred amphiphilic behavior to the whole system that acted as driving force for its self-assembling in aqueous media. Depending on the polymer concentration it was possible to obtain different architectures. The TEM micrographs permitted to follow the evolution of the system from single vesicles toward necklace entanglements. In this work, we discuss the mechanism that would be involved in the evolution of the system's morphology as a function of the block copolymer concentration. In addition, the proposed star shaped block copolymer presented good solubilizing properties that were used to disperse in water, poorly soluble molecules such as chlorine-carbazoles, which were used to investigate the suitability of the self-assembled nanostructures as drug nano-carriers.
THE ACS NEARBY GALAXY SURVEY TREASURY. XI. THE REMARKABLY UNDISTURBED NGC 2403 DISK

We present detailed analysis of color-magnitude diagrams of NGC2403, obtained from a deep (m<28) Hubble Space Telescope (HST) Wide Field Planetary Camera 2 observation of the outer disk of NGC2403, supplemented by several shallow (m<26) HST Advanced Camera for Surveys fields. We derive the spatially resolved star formation history of NGC2403 out to 11 disk scale lengths. In the inner portions of the galaxy, we compare the recent star formation rates (SFRs) we derive from the resolved stars with those measured using GALEX FUV + Spitzer 24-micron fluxes, finding excellent agreement between the methods. Our measurements also show that the radial gradient in recent SFR mirror s the disk exponential profile to 11 scale lengths with no break, extending to SFR densities a factor of 100 lower than those that can be measured with GALEX and Spitzer (2x10^{-6} M_{\sun} yr^{-1} kpc^{-2}). Furthermore, we find that the cumulative stellar mass of the disk was formed at similar times at all radii. We compare these characteristics of NGC2403 to those of its "morphological twins," NGC300 and M33, showing that the structure and age distributions of the NGC2403 disk are more similar to those of the relatively isolated system NGC300 than to those of the Local Group analog M33. We also discuss the environments and HI morphologies of these three nearby galaxies, comparing them to integrated light studies of larger samples of more distant galaxy disks. Taken together, the physical properties and evolutionary history of NGC2403 suggest that the galaxy has had no close encounters with other M81 group members and may be falling into the group for the first time.
Predictive analysis of late rice potential productivity in Dongting Lake Area (DLA) based on stepwise diminishing method

The Dongting Lake Area(DLA),a famous and important commodity grain production base in China,is one of nine industrial belts of the top agricultural products,and belongs to the top grain industrial belt of double-cropping paddy in the Yangtze River Basin.Therefore,the investigations based on the rice productivity of the DLA is vital for the optimization of the land resource allocation,assessment of the paddy field ecosystem,design of agricultural development plan and protection of agricultural eco-environment.According to the meteorological analysis data from 2003 to 2007 and the soil analysis data of the Second National Field Survey,utilizing the stepwise diminishing method of light,temperature,water and soil,a comparative research was carried out to build an appropriate rice potential productivity model for the DLA.Two rice potential productivity models(photosynthesis-temperature potential productivity calculation by step-by-step model and FAO-AEZ model) were investigated,followed by the analysis of the spatial distribution of late rice potential productivity with the assistance of Geographic Information System(GIS).The results showed that the mean simulation value of five years(2003-2007) predicted by a step-by-step model achieved 7808.072 kg/hm2,higher than the observation value(5904 kg/hm2);while the simulation value obtained by FAO-AEZ model was only 5687.45 kg/hm2,even lower than the mean observation value,which is unreasonable for the actuality of DLA.This disclosed that the model based on step-by-step calculation of photosynthesis-temperature potential productivity was appropriate to predict the late rice potential productivity in the study area.At the same time,the research also revealed that the late rice potential productivity in the DLA decreased gradually from northwest to southeast.The regions of Lixian,Anxiang,Hanshou and Linli counties in Changde city contributed high or medium yields,while the low yield areas were mainly distributed in Changsha,Yiyang and Yueyang cities.The late rice potential productivity of the DLA was inadequate,and the low yield area occupied 45% of the total DLA,which exhibited great potential for the improvement of the late rice yield by means of sound tillage control measures,including rational fertilization system and water management.
Mediterranean Trading and Innovation Centre 

Context:
The context of the project is characterized by the presence of two factors, generally considered as major obstacles for development: insularity and marginality.  It is about ties that are always stronger in the economic factors, characterized by the continuous improvements of technology and of the knowledge with which it is necessary to take into account to be able to stay competitive in the internal European market and in the global market.  Innovation is an increasingly strong, for the territorial systems and businesses, and can take very different forms: dall'invenzione resulting from the research, the adjustment process and product, the introduction of new approaches organizational and marketing models to entry into new markets, etc.. 
Aims: 
The main objectives pursued by the project are: 
Stimulating the system borders on the importance of innovation and application of methods and techniques developed ad hoc; 
Create a service centre and a slight technological structure to disseminate technical IMT and provide support for their implementation; 
Creating a support network for cross-border cooperation by promoting joint pilot projects in the field of the IMT.
PROCESS FOR MAKING ANTIMICROBIAL POLYMER ARTICLES

This invention relates to a process for making articles antimicrobial and odor inhibiting, which comprises using vacuum deposition and electron beam techniques to graft amino-reactive functional groups onto polymeric material which the article comprises, followed by contacting the polymeric material with a chitosan solution.