SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Improved pinless connector.

The present invention relates to an improved pinless connector for use in microelectronics having an elastomer resin comprising polysiloxane and filler. In particular the elastomer resin has a tensile strength greater than 170 psi and comprises (i) a crosslinked polysiloxane comprising about 70 to 90 weight % of a crosslinked random copolymer of dimethylsiloxane and diphenylsiloxane and (ii) about 10 to 30 weight % of filler comprising zinc oxide and a lanthanide oxide. <IMAGE>
Membrane fusion mediated dermal allergy immunotherapy

In this project we aim to develop a new delivery platform for allergy vaccines with a high efficacy and a high safety profile combining membrane fusion-mediated delivery and microneedle-based dermal delivery.

Background: Within the ERC Starting Grant “Direct Drug Delivery”, I developed a method for the controlled fusion of liposomes with cells. A set of complementary peptide amphiphiles (coilK and coilE), able to form heterodimeric coiled coils, were shown to induce targeted and efficient fusion between two opposing membranes. More importantly, we have shown that this method of fusion can be applied to liposomes and to live cells. Since liposomes can be used as drug or vaccine carriers, this enables the direct delivery of these compounds into live cells. 

The Problem: Allergen-specific immunotherapy for treating allergies such as asthma is currently performed via chronic subcutaneous administration of allergen extracts to patients. Unfortunately, it requires monthly injections for several years to achieve the desired long-lasting immunological tolerance. These vaccinations are typically performed by intramuscular or subcutaneous injections, causing pain and stress. Therefore there is a need for a new and more efficient administration platform to achieve shorter, safer and more patient-friendly protocols.

Our solution: Dermal delivery of vaccines offers a great potential, due to the large number of immune cells present in the skin. In order to increase the efficacy of current allergen-specific immunotherapy, it is our idea to use the membrane fusion heterodimeric coiled coil peptide pair to induce efficient cellular uptake and processing of a commercially used allergen (rBet v1) encapsulated in liposomes in order to increase its efficacy as an allergy vaccine.
Shifting the obesity epidemic in iberia-latin american cities: applying interdisciplinary, intersectional and intersectoral approaches to understand and change key obesogenic causes

More than half of the worldwide population (55%) is overweight or obese (O/O), while the increasing trends are leading to shorten life expectancy. Tackling O/O is a European priority, and innovative actions to achieve this are urgently needed: no country has so far succeeded in reducing its growth. O/O are related to several axes of social inequality, such as socioeconomic status, gender, ethnicity, age, and place of residence. O/O are more frequent in more unequal societies and increase with urbanisation. The highly urbanised Iberia-Latin American region has strong historical, political, economic and cultural bonds. However, this region has also considerable heterogeneity in the degree of social and gender inequalities (SGI), urbanisation, and in the prevalence of O/O. Thus, this transnational scenario holds great potential for the analysis of the urban SGI in O/O. 
The overall objective of this project is to develop an analytical model to assess the determinants of SGI in O/O in the Iberia-Latin American cities over a recent time period, and to inform urban policies by integrating interdisciplinary, intersectional and intersectoral approaches. A mixed methods study design will be applied, with a cross-sectional multi-city study followed by a public policy analysis and the development of recommendations for polices and interventions to address SGI in O/O. A gender perspective will be adopted throughout all the action. The novel integration of these approaches will contribute to tackling urban SGI in O/O by providing a more comprehensive understanding of its drivers and by finding new avenues for improving equity-based urban policies. The project will also provide insights to reshape O/O as a systemic problem worldwide. Moreover, the action will have a key impact on my career development, on the institutions involved, and on relevant target audiences (researchers, practitioners, policy makers) as well as on the wider community.
A Clinical Effect Comparison between Songling Xuemaikang Capsule with Lescol Capsule in Treating Hyperlipemia

Objective To observe the clinical effect and to evaluate the security of Songling Xuemaikang Capsule on treating hyperlipemia.Methods 120 cases with hyperlipemia were divided randomly into two groups and was given respectively Songling Xuemaikang Capsule plus Lescol Capsule and Lescol Capsule individually.They were treated for 6 weeks.TC、TG and HDL-C were determined before treatment and 6 weeks after treatment.Results There was a significantly difference between before and after treatmentand was also a significantly difference between after treatment of two groups in HDL-C,but not difference in TC and TG.Conclusion Songling Xuemaikang Capsule was a kind of reliable and safe antilipimic angent which could be applied for the elderly for a long-term treatment.
Tunable holographic drop filter with quasi phase-conjugate fiber coupling

The present invention is a method and apparatus for a rotating, tunable, holographic drop filter connected to a fiber optic source. The filter uses a quasi phase-conjugate optical system for a drop-channel fiber coupling and WDM channels which are introduced to the system. The light from these channels is collimated and passed through a volume phase holographic material so that only one WDM channel is diffracted and the rest pass through the holographic material unaffected. A quasi phase-conjugate diffracted beam is generated by the optical system to reflect the diffracted channel back towards the holographic material. The reflected light is Bragg matched to the holographic material so that it is re-diffracted along a path identical to the original incident light beam. A free-space circulator may be used to direct the diffracted beam to a fiber optic collimator, which is different from the fiber optic collimator of the incident light beam.
Wrist and arm sensing technologies for cardiac arrhythmias detection

Abnormal heart rhythms are a major cause of cardiovascular disease and death in Europe.  Sudden cardiac death accounts for 50% of cardiac mortality in developed countries; ventricular tachycardia or ventricular fibrillation is the commonest underlying arrhythmia. In the ambulatory population, atrial fibrillation is the commonest one, and is associated with increased risk of stroke and heart failure, particularly in the aged population. If arrhythmias are detected at an early stage of heart disease, appropriate treatment can be effective, reducing disability and death. However, in the early stages of disease these may be transient, lasting only a few seconds, and thus difficult to detect. Current approaches to cardiac rhythm monitoring include: a) non-invasive external recording devices; which are suitable for short term (<24h) recording, and b) implantable loop recorders, which are inserted subcutaneously beneath the chest wall; capable of monitoring heart rhythm for extended periods, but there is considerable expense associated with the device, hospitalisation costs and risk of infection.

  The proposed joint research project through staff exchange activities, will investigate enabling technologies for non-invasive recording heart rhythm during long periods of time (>36h), using a wrist or arm wearable device with novel ECG sensing techniques and embedded real-time cardiac arrhythmia detection processes. The problem of extracting the far-field heart electrogram signal from noise components will be addressed using smart denoising algorithms.

  The project will impact by establishing a successful international and intersectoral partnership for the development of new technologies addressing a significant cardiovascular healthcare problem. These technologies will be suitable for integration into current e-Health and cardiac information systems, and will impact on healthcare costs reduction by improved efficiency in the diagnosis and early treatment of cardiac disease
Cell-Based Strategies for the Treatment of Injury to the Developing Lung

Extremely preterm infants often develop a chronic lung disease known as bronchopulmonary dysplasia (BPD). Although advances in perinatal care enable survival following extremely preterm birth, BPD remains a common complication that lacks specific treatment. Since the landmark discovery of stem cells, their therapeutic potential in regenerative medicine is being harnessed for various diseases including BPD. This chapter reviews recent advances in our understanding of lung stem cells and the exciting pre-clinical data showing the potential for stem cells to prevent/repair lung damage in experimental models of BPD. It is expected that these findings will lead in the near future to clinical trials investigating stem cell therapy in preterm infants. Almost half a century since the first description of BPD, there may be a therapy on the horizon.
KEY BLADE AND METHOD OF PRODUCING THE SAME.

Un panneton de clé ayant un axe d'insertion longitudinal (A) comprend un combinaison de découpes allongées généralement en forme d'encoches biseautées s'étendant longitudinalement (38), destinées à agir de concert avec une rangée (23) de goupilles de verrouillage (23a-23e) à mouvement d'élévation et de rotation faisant partie d'une serrure (18) à cylindre rotatif. Chaque goupille de verrouillage est munie d'un palpeur s'étendant transversalement et s'engageant dans la combinaison des découpes (38) au moment de l'insertion du panneton de clé dans la serrure. La combinaison des découpes comprend un certain nombre de découpes concaves (40-44) se déplaçant longitudinalement et transversalement de façon à correspondre à des mouvements de rotation et d'élévation spécifiques des goupilles de verrouillage, ce qui va permettre l'ouverture de la serrure.
<i>SPITZER</i>SECONDARY ECLIPSES OF THE DENSE, MODESTLY-IRRADIATED, GIANT EXOPLANET HAT-P-$20{\rm b}$ USING PIXEL-LEVEL DECORRELATION

HAT-P-20b is a giant exoplanet that orbits a metal-rich star. The planet itself has a high total density, suggesting that it may also have a high metallicity in its atmosphere. We analyze two eclipses of the planet in each of the 3.6- and 4.5 micron bands of Warm Spitzer. These data exhibit intra-pixel detector sensitivity fluctuations that were resistant to traditional decorrelation methods. We have developed a simple, powerful, and radically different method to correct the intra-pixel effect for Warm Spitzer data, which we call pixel-level decorrelation (PLD). PLD corrects the intra-pixel effect very effectively, but without explicitly using - or even measuring - the fluctuations in the apparent position of the stellar image. We illustrate and validate PLD using synthetic and real data, and comparing the results to previous analyses. PLD can significantly reduce or eliminate red noise in Spitzer secondary eclipse photometry, even for eclipses that have proven to be intractable using other methods. Our successful PLD analysis of four HAT-P-20b eclipses shows a best-fit blackbody temperature of 1134 +/-29K, indicating inefficient longitudinal transfer of heat, but lacking evidence for strong molecular absorption. We find sufficient evidence for variability in the 4.5 micron band that the eclipses should be monitored at that wavelength by Spitzer, and this planet should be a high priority for JWST spectroscopy. All four eclipses occur about 35 minutes after orbital phase 0.5, indicating a slightly eccentric orbit. A joint fit of the eclipse and transit times with extant RV data yields e(cos{omega}) = 0.01352 (+0.00054, -0.00057), and establishes the small eccentricity of the orbit to high statistical confidence. Given the existence of a bound stellar companion, HAT-P-20b is another excellent candidate for orbital evolution via Kozai migration or other three-body mechanism.
Unity

The Unity vision is to strengthen the connection between the police and the diverse communities they serve to maximise the safety and security of all citizens. The end-user focus of Unity shall identify best practices in Community Policing (CP) through primary and secondary research to enhance cooperation between Law Enforcement Agencies (LEAs) and citizens through the development and live pilot demonstrations of technological tools in six EU member states that facilitate, strengthen and accelerate community and LEAs communications. These tools shall be amplified and supported by the design and delivery of CP training and awareness raising activities to LEAs, citizens and community partners, including online virtual communities. Unity will provide LEAs with a new CP model and shared framework of governance and enabling tools and technology to support closer cooperation for greater, more effective and efficient and more inclusive CP. The citizen-centred approach of Unity support the combined protection, safety, security and well-being of communities, but it will also support a more collective, shared ownership of large scale, collective risk.  Coordinated by pioneers and practitioners in CP, Unity seeks new ways of working in which the police will serve as a catalyst for change within communities, helping the latter to become an integral part of the solution, and thereby sharing the ownership and delivery of a sustainable CP model which simultaneously embraces the benefits of technology while meeting diverse community needs. This new and sustainable citizen-centred CP model will have community trust and confidence at its heart, with the ability for two-way flows of information and communication to allow for greater understanding of the problems and issues faced by communities. By working with citizens and community stakeholders to arrive at a full understanding of their concerns, targeted interventions and solutions can be agreed to keep local communities safe
10,000-PSI MULTILATERAL FRACKING SYSTEM WITH LARGE INTERNAL DIAMETERS FOR UNCONVENTIONAL MARKET

Provided is a frac window system, a well system, and a wellbore stimulation method. The frac window system, in one aspect, includes an elongated tubular having a first end and a second end with an opening defined in a wall of the elongated tubular between the first end and the second end, the wall having an inner surface and an outer surface, wherein the opening in the wall is configured to align with a window of a wellbore casing. The frac window system, according to this aspect, may further include a polished bore receptacle coupled to the first end of the elongated tubular, the polished bore receptacle having an inside diameter (ID1) sufficient to engage with a high-pressure frac string.
Food Art Movement Energy - the ROAD to Country Experience

F.A.M.E road project is build on the experience gained from Greenroad (greenroad.it), a Best Practice (result of a Project funded by the Apulia Region and implemented in the area of Taranto) for development of naturalistic and rural areas aiming at a sustainable growth based on the conservation and the valorization of the identity of target territories. The approach is holistic and participatory: cultural, naturalistic, economic and social aspects are all comprised in the planning and development of the activities of the model and in each phase of the project; moreover, local stakeholders are invited to participate and join to the processes, including individual citizens and tourists. The greenroad model is based on four pillars, the so called F.A.M.E. pillars, on which the actions of project are based on: Food, Art, Movement and Energy.

The overall objective of the project is to test and adjust a valorization model, starting from a previous best practice, applied in Apulia. The model aims at providing local stakeholders with competence, networking capability, sustainable strategies and tools to conserve and protect natural and cultural territorial assets and at the same time, promoting and developing economic and touristic activities based on the same assets. Municipality of Gravina is the lead partner in cooperation with Municipality of Grottaglie and Univesus Consortium on the Italian side and Municipality of Aigialeia and European Regional Framework for Cooperation on the Greek side.
European industrial doctorate for efficient multidisciplinary design optimization of multifunctional aerospace composite structures

Modern aeronautical structures are increasingly made of composite materials due to their well-known benefits. Optimizing
the design of aerospace composites vis-à-vis the entire range of operational constraints (i.e. reliability, stability, strength,
weight, noise, manufacturability and cost) to which the aircraft structures are subject, results in a particularly challenging task
for the structural designer. Despite the volume of recent work dedicated to new Multidisciplinary Design Optimization (MDO)
models and techniques, the ‘No free lunch theorem in optimisation’ is constantly confirmed.
A genuine need is therefore identified for a programme that will: i)Develop, deliver and implement novel and efficient
structural MDO technological tools for the European aerospace industry, ii)Nurture and train the next European generation of
MDO research professionals. OptiMACS has an intersectoral character, drawing know-how from both academic and
industrial research and innovation teams. It also has an intensely multi-disciplinary character, coupling expertise from
mechanical, aerospace, manufacturing and software engineering, as well as from the area of applied mathematics.
On the research side, OptiMACS will focus on improving the accuracy and efficiency of the MDO platform currently
employed by AIRBUS. This will be achieved by enhancing the design models and criteria related to composites failure and
manufacturing, developing and implementing multiscale models for composites as well as investigating advanced MDO
algorithms and architectures for enhancing efficiency.
On the training side, OptiMACS will provide a fully supportive environment for 5 ESRs. A training programme aiming at
developing both the research as well as the transferable skills of the Fellows has been designed. All Fellows will have the
opportunity to work in a multi-disciplinary environment, spending at least 50% of their time at the premises of the industrial
beneficiaries.
Mould for fastening a metallic piece on one side of an ophtalmic lens.

Dans ce moule, la paroi latérale cylindrique de la cavité de moulage (8) a un diamètre intérieur (D) plus grand que le plus grand diamètre existant de lentille ophtalmique, et une membrane (25) en gros cylindrique, en une matière élastomère, est disposée concentriquement à l'intérieur de la cavité de moulage et définit avec la paroi latérale cylindrique de ladite cavité une chambre annulaire (31) à volume variable, ladite membrane étant expansible et rétractable radialement par l'action d'un fluide alternativement extrait de ladite chambre annulaire et introduit dans celle-ci.
Targeting glioblastoma using combinatorial therapeutic nanovaccine

The proposal aims at the synthesis, characterisation and application of a novel therapeutic nanovaccine (TNVax) that holds multiple modules for targeting glioblastoma multiforme (GBM). The proposed TNVax formulation includes a gold nanocage core encapsulating Temozolamide (TMZ), coated with an extremophilic bacterial polysaccharide, mauran functionalised with anti-PD-L1 antibody and anti-CD133 antibody. The us of NVax nanoparticles (NPs) offers a combinatorial approach in killing GBM cells both by immuno- and chemo- therapeutically. Site-specific delivery of the payload will stimulate the host immune system and channel the immune cells to the target site. Functionalisation of the anti-PD-L1 antibody on drug-encapsulated
NPs would significantly alter the immune suppression caused by GBM cells on TNVax delivery. In addition to anti-PD-L1 antibody, the TNVax particles contain tumour specific monoclonal antibody that specifically recognizes CD133 antigen and facilitates strong binding. This approach would enhance the amount of antitumour activity offered by multiple means and thereby leaving a strong immune response against GBM based on antigen-antibody interactions. TNVax NPs will be synthesised and characterised using microscopic and spectroscopic techniques and then subjected to in vitro and in vivo evaluations. In vitro studies will be performed for drug release kinetics and cytotoxicity using immunofluorescence and FACS analysis. Induction of immune response by TNVax NPs will be evaluated using macrophage activation, induction of T-cell activity and cytokine production under in vitro conditions. The pharmacokinetic and pharmacodynamic studies
will be carried out and histopathological examinations performed using appropriate murine models induced with GBM cell lines. The potential outcomes of the proposed studies will help patients who suffer from early and advanced GBM by eradicating the disease permanently and leaving good immunological memory.
METHODS, APPARATUSES, AND SYSTEMS FOR MOVABLE PARTITIONS

Movable partition systems include an elongated drive member with fixed, offset ends extending along a track, a partition that is automatically and manually movable along the track, the partition hanging from a trolley disposed at least partially within the track, a motor carried by the movable partition configured to drive a rotatable drive member engaged with the elongated drive member, and a clutch coupled with the motor configured to engage or disengage the rotatable drive member from the motor. Methods of moving a partition along a track include actuating a motor carried by a movable partition to drive rotation of a drive member while a clutch mechanism is engaged, and manually moving the partition along the track while the clutch mechanism is disengaged. Methods of installing a movable partition system include coupling a trolley to a rotatable drive member and placing the trolley within a channel of a track.