SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Erlotinib as salvage treatment after failure to first-line gefitinib in non-small cell lung cancer

Chemotherapy is the mainstay treatment for advanced non-small cell lung cancer (NSCLC). Gefitinib, an epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI), has been recently shown to be effective as a first-line treatment in Asian patients with advanced NSCLC, especially for those with favourable clinical features such as female, non-smoker and adenocarcinoma. However, resistance to gefitinib ensues invariably and there is little evidence as for the effectiveness of subsequent salvage treatment. The purpose of this study is to evaluate the efficacy of erlotinib, another EGFR-TKI, after failed first-line use of gefitinib.Retrospective review of NSCLC patients with favourable clinical features who received gefitinib as first-line treatment and subsequent salvage treatment with erlotinib.A total of 21 patients with NSCLC were included in the study. Among them, 18 (85.7%) patients had disease control with gefitinib and 12 (57.1%) patients with salvage erlotinib. There was an association between the disease control with gefitinib and erlotinib (p = 0.031). The disease control rate of erlotinib was independent of the chemotherapy use between the two EGFR-TKIs.For NSCLC patients with favourable clinical features, erlotinib was effective in those who had prior disease control with first-line gefitinib.
Connecting expert enthusiasts with potential shoppers within a shared economy model

When buying a pair of running shoes, would you trust a peer who just ran a marathon or a sales person who might work on commission? The latest web and mobile technologies enable us to connect with people across time and space. ibbü takes qualified peer advice to the next level: we can directly connect with peer experts and get their advice. 
Our solution ibbü brings together brands (demand-side) with experts (supply-side) to convert consumers (end-users) into shoppers within a conversational commerce marketplace based on a shared economy model. Brands manage their campaigns as they wish. Savvy peers are curated by ibbü based on criteria that highlight expertise and skill. 
We already have 22 brands and 150 active experts with 300,000+ advices through ibbü. We are now focusing on the existing iAdvize clients and are evangelizing further fast-moving consumer good brands starting with the different retail channels. We calculate our market size based on the retail market we will penetrate with a TAM of $340 billion, SAM $200 billion and SOM of $20 billion. 
ibbü generates an average of €1.23 per chat based on direct revenues, i.e. 16.67% of the commission of the brand’s payments to the expert and on indirect revenues, i.e. we charge our clients (brands) €0.90 to set up each chat. 
ibbü can help respond to the challenge of unemployment and social inclusion by having citizens profit from the shift to e-commerce and less retail shelve space. Also, whilst the gap between female and male unemployment has narrowed in the past, it still remained high and ibbu can help reverse that. The shift from brick and mortar to e-commerce can also benefit citizens: they can profit from becoming the middle man and secure an income for sharing an honest opinion.
Towards artificial enzymes: bio-inspired oxidations in photoactive metal-organic frameworks

Metal-organic frameworks (MOFs) are key compounds related to energy storage and conversion, as their unprecedented surface areas make them promising materials for gas storage and catalysis purposes. We believe that their modular construction principles allow the replication of key features of natural enzymes thus demonstrating how cavity size, shape, charge and functional group availability influence the performances in catalytic reactions. This proposal addresses the question of how such novel, bio-inspired metallo-supramolecular systems can be prepared and exploited for sustainable energy applications. A scientific breakthrough that demonstrates the efficient conversion of light into chemical energy would be one of the greatest scientific achievements with unprecedented impact to future generations. We focus on the following key aspects:

a) MOFs containing novel, catalytically active complexes with labile coordination sites will be synthesised using rigid organic ligands that allow us to control the topologies, cavity sizes and surface areas. We will incorporate photosensitizers to develop robust porous MOFs in which light-absorption initiates electron-transfer events that lead to the activation of a catalytic centre. In addition, photoactive molecules will serve as addressable ligands whereby reversible, photo-induced structural transformations impose changes to porosity and chemical attributes at the active sites. 

b) Catalytic studies will focus on important oxidations of alkenes and alcohols. These reactions are relevant to H2-based energy concepts as the anodic liberation of protons and electrons can be coupled to their cathodic recombination to produce H2. The studies will provide proof-of-concept for the development of photocatalytic systems for the highly endergonic H2O oxidation reaction that will be explored using most stable MOFs.  Further, gas storage and magnetic properties that may also be influenced by light-irradiation will be analysed.
Playing Squash Against Ralph Keeney: Should Weaker Players Always Prefer Shorter Games?

In games such as squash, it is generally assumed that weaker players maximize their chances of winning when they play as few points as possible against superior opponents. The failure of squash players to recognize this and to prefer shorter games against stronger opponents has been cited multiple times in the literature as evidence of the foibles of lay decision makers. This error has been categorized as an error of application, attributed to the representativeness bias, and ascribed to sudden death aversion. Decision analyses presented here demonstrate, however, that under certain conditions the maxim for weaker players to minimize the number of points played against better players does not lead to optimal decisions. This holds true for choices about how many points to play in tiebreakers and the choice between playing games to 9 or to 15 points. The analyses illustrate the danger in overgeneralizing about lay tendencies to make irrational or suboptimal choices without careful examination of the task environment. The analyses also illustrate that optimization will not necessarily involve a corner solution that minimizes or maximizes total number of points played even for such a straightforward game as squash or in analogous circumstances off the court.
Asynchronous trustworthy transactions

Although Nakamoto’s original blockchain protocol has spurred significant innovation and financial interest in the last decade, its energy consumption  becomes problematic. Besides, transaction latencies are prohibitively high and the system sustains a very low throughput. We have witnessed hundreds of alternative solutions in the last decade. Each seeks to reduce energy consumption, to obtain lower latency, or to improve throughput. All proposed alternatives, however, sacrifice either trustworthiness or efficiency. In retrospect, this is not surprising. All these solutions seek to solve a notoriously difficult problem: consensus. In short, the set of nodes in the network have to agree on the same position of a block in the chain, despite the possibility of malicious behaviour of some of the nodes, or network delays. The consensus problem has been the most studied problem in distributed computing, and many impossibility and lower bound results were established. These results translate into inherent trade-offs between trust and efficiency.  In the context of our ERC AOC (Adversary-Oriented Computing) project (advanced grant), we worked on classifying distributed computing problems according to their hardness. While doing so, we revisited the issue of implementing a trustworthy payment system, i.e., the problem solved in Nakamoto’s paper.  This led us to a very interesting discovery: Current blockchain protocols are tackling a problem, i.e., consensus, which is unnecessarily strong for their purpose of building a payment system. More specifically, we have shown that it is enough to solve a problem called secure causal broadcast to implement trust in any tokenized application. This is significantly simpler than consensus. We devised a generic asynchronous protocol to solve the secure causal broadcast problem, which we called AT2, Asynchronous Trustworthy Transactions, which we patented. The goal of this project is to pave the path to its commercialization.
METHOD FOR PILOTING A POWERTRAIN FOR POLLUTION CONTROL OF THE EXHAUST LINE THEREOF

L'invention concerne un procédé de pilotage d'un groupe motopropulseur (GMP) de véhicule, le pilotage comprenant un premier mode (NOx f) et un deuxième mode (CO2 f) de fonctionnement, le premier mode (NOx f) étant moins émissif d'un polluant que le deuxième mode (CO2 f), caractérisé en ce que, lors d'un premier mode (NOx f), on détermine pour la fenêtre courante si la différence de la quantité de polluant (X) en sortie de la ligne avec une quantité de polluant cible est inférieure à un premier seuil (a), on détermine si la somme de ces différences (SNOx X) sur les fenêtres successives est inférieure à un deuxième seuil (c) et si l'efficacité de l'élément de dépollution (RCS) est jugée suffisante pour traiter le polluant avec le deuxième mode (CO2 f), celui-ci est appliqué au début de la fenêtre courante suivante.
TIRE SUPPORT

Tire support rings mounted within a tubeless tire to prevent the tire from collapsing upon the occurrence of a leak in the tire and to support a vehicle until the leak can be repaired.
SILICONE CLIP

Disclosed is a clip (100) for a bracelet and/or a necklace. The clip in a closed state having a through hole (102) allowing said clip to wreathe an elongated member (301) of a bracelet and/or necklace. The clip comprises: a first part (120) and a second part (130), the first and second parts being connected by a hinge (101); and a resilient element (150) arranged in the second part. The resilient element comprising a first gripping surface for frictionally gripping a surface (151) of the elongated member. The resilient element being spaced apart from the first part. The first part comprises a rigid second gripping surface (121, 122) for gripping a surface of the elongated member, and the resilient element and the rigid second gripping surface allows the clip to be releasably secured at selected positions along the elongated member and allows said clip in a closed state to be movable along the elongated member, on which it is positioned by exerting a force in the axial direction.
Facilitating partner notification through an online messaging service: Let Them Know

Let Them Know (www.letthemknow.org.au) is an Australian internet based service designed to support individuals diagnosed with an STI to notify sexual partners using anonymous or personal text messages. A review of user activity and acceptability of the website was performed. Between 17 March 2010 and 31 March 2011, of 13 024 website visits, 4863 (37%) visits resulted in a text message being sent. From 3 December 2010, of 1383 consecutive users, 963 (70%) indicated they were more likely to contact a partner because of the website. A short period of misuse was identified and controlled, and additional measures to monitor for and prevent misuse were subsequently implemented. Web-based notification systems such as the Let Them Know website can help to facilitate partner notification for individuals who may be reluctant to do this in person.
DroidPortrait: Android Malware Portrait Construction Based on Multidimensional Behavior Analysis

Recently, security incidents such as sensitive data leakage and video/audio hardware control caused by Android malware have raised severe security issues that threaten Android users, so thus behavior analysis and detection research researches of malicious Android applications have become a hot topic. However, the behavioral portrait of Android malware that can depict the behavior of Android malware is not approached in previous literature. To fill this gap, we propose DroidPortrait, an Android malware multi-dimensional behavioral portrait construction approach. We take the behavior of Android malware as an entry point and extract an informative behavior dataset that includes static and dynamic behavior from Android malware. Next, aiming at Android malware that contains different kinds of behaviors, a behavioral tag is defined then combined with a machine learning (ML) algorithm to implement the correlation of these behavioral tags. Android malware behavioral portrait architecture based on behavior analysis and its design is investigated, as also an optimized random forest algorithm is conceived then combined with Android malware behavioral portrait to detect Android malware. The evaluation findings indicate the DroidPortrait can depict behavioral characteristics of Android malware comprehensive and detect them with high performance.
MicroRNAs as tools to predict glucocorticoid response in inflammatory bowel diseases

In spite of the introduction in therapy of highly effective biological agents, glucocorticoids (GCs) are still employed to induce remission in moderate to severe inflammatory bowel diseases (IBD), but considerable inter-individual differences in their efficacy and side effects have been reported. The effectiveness of these drugs is indeed very variable and side effects, particularly severe in pediatric patients, are common and often unpredictable: the understanding of the complex gene regulation mediated by GCs could shed light on the causes of this variability. In this context, microRNAs (miRNAs) represent a new and promising field of research. miRNAs are small non-coding RNA molecules that suppress gene expression at post-transcriptional level, and are fine-tuning regulators of diverse biological processes, including the development and function of the immune system, apoptosis, metabolism and inflammation. Emerging data have implicated the deregulated expression of certain miRNA networks in the pathogenesis of autoimmune and inflammatory diseases, such as IBD. There is a great interest in the identification of the role of miRNAs in the modulation of pharmacological response; however, the association between miRNA and GC response in patients with IBD has not yet been evaluated in a prospective clinical study. The identification of miRNAs differently expressed as a consequence of GC treatment in comparison to diagnosis, represents an important innovative approach that could be translated into clinical practice. In this review we highlight the altered regulation of proteins involved in GC molecular mechanism by miRNAs, and their potential role as molecular markers useful for predicting in advance GC response.
Privatization of power distribution utility in India through restructuring and reformation

After enactment of Electricity Act '2003 in India, a comprehensive change is happening in Indian electricity market, and power industries are going through a reformation process to cope with the market change. In the post Electricity Act'2003 scenario restructuring & reformation is happening very fast by unbundling the power Utility by formation different business units like GENCO (Generation Company), TRANSCO (Transmission Company), & DISCOM (distribution company) to improve the overall efficiency of the Utility. Further to minimize the Aggregated Technical & Commercial (AT & C) losses, privatization of power distribution utility (DISCOM) is going on. Privatization is portrayed as means of improving efficiency and bringing in funds for investment. However, governments often have to go to considerable lengths to attract investors. Such measures include assuming the debt of the enterprise, avoiding unbundling of the sector and increasing prices. Despite privatization, governments still have responsibility for the provision of stable and affordable electricity. Hence after privatization there is a need for further support from the government to subsidize electricity prices and in some. Alternatively, governments may also restrict the create problem as firms may be unhappy to see their profits are squeezed. However, whatever measures are used, private firms should start disconnecting non-payers quickly, with presumably social implications. While privatization may deliver in the short term by reducing leakages and providing more effective billing, the longer-term implications are less clear. Possibly inefficient public sector enterprises may be replaced with powerful private sector concerns, accountable to shareholders with no democratic responsibility in the country where they are delivering this essential resource. This is particularly significant in India where the institutional infrastructure is such that regulation is weak. Rather than blindly privatizing, policy makers need to relegate privatization to its proper place of just one of a number of policy reform options - and one that comes at a substantial cost.
Effect of Oral Methylprednisolone on Decline in Kidney Function or Kidney Failure in Patients With IgA Nephropathy

The effect of glucocorticoids on major kidney outcomes and adverse events in IgA nephropathy has been uncertain.To evaluate the efficacy and adverse effects of methylprednisolone in patients with IgA nephropathy at high risk of kidney function decline.An international, multicenter, double-blind, randomized clinical trial that enrolled 503 participants with IgA nephropathy, proteinuria greater than or equal to 1 g per day, and estimated glomerular filtration rate (eGFR) of 20 to 120 mL/min/1.73 m2 after at least 3 months of optimized background care from 67 centers in Australia, Canada, China, India, and Malaysia between May 2012 and November 2019, with follow-up until June 2021.Participants were randomized in a 1:1 ratio to receive oral methylprednisolone (initially 0.6-0.8 mg/kg/d, maximum 48 mg/d, weaning by 8 mg/d/mo; n = 136) or placebo (n = 126). After 262 participants were randomized, an excess of serious infections was identified, leading to dose reduction (0.4 mg/kg/d, maximum 32 mg/d, weaning by 4 mg/d/mo) and addition of antibiotic prophylaxis for pneumocystis pneumonia for subsequent participants (121 in the oral methylprednisolone group and 120 in the placebo group).The primary end point was a composite of 40% decline in eGFR, kidney failure (dialysis, transplant), or death due to kidney disease. There were 11 secondary outcomes, including kidney failure.Among 503 randomized patients (mean age, 38 years; 198 [39%] women; mean eGFR, 61.5 mL/min/1.73 m2; mean proteinuria, 2.46 g/d), 493 (98%) completed the trial. Over a mean of 4.2 years of follow-up, the primary outcome occurred in 74 participants (28.8%) in the methylprednisolone group compared with 106 (43.1%) in the placebo group (hazard ratio [HR], 0.53 [95% CI, 0.39-0.72]; P < .001; absolute annual event rate difference, -4.8% per year [95% CI, -8.0% to -1.6%]). The effect on the primary outcome was seen across each dose compared with the relevant participants in the placebo group recruited to each regimen (P for heterogeneity = .11): full-dose HR, 0.58 (95% CI, 0.41-0.81); reduced-dose HR, 0.27 (95% CI, 0.11-0.65). Of the 11 prespecified secondary end points, 9 showed significant differences in favor of the intervention, including kidney failure (50 [19.5%] vs 67 [27.2%]; HR, 0.59 [95% CI, 0.40-0.87]; P = .008; annual event rate difference, -2.9% per year [95% CI, -5.4% to -0.3%]). Serious adverse events were more frequent with methylprednisolone vs placebo (28 [10.9%] vs 7 [2.8%] patients with serious adverse events), primarily with full-dose therapy compared with its matching placebo (22 [16.2%] vs 4 [3.2%]).Among patients with IgA nephropathy at high risk of progression, treatment with oral methylprednisolone for 6 to 9 months, compared with placebo, significantly reduced the risk of the composite outcome of kidney function decline, kidney failure, or death due to kidney disease. However, the incidence of serious adverse events was increased with oral methylprednisolone, mainly with high-dose therapy.ClinicalTrials.gov Identifier: NCT01560052.
Washing machine

A washing machine including a cabinet having with an inlet port formed at a front panel for laundry insertion thereinto and a door to open or close the inlet port; a tub within the cabinet for storing wash water; a drum in communication with the inlet port, and rotatably provided within the tub; a detergent dispenser provided below the inlet; a water passage to supply wash water from a water source to at least one of the tub and the detergent dispenser; and a connecting passage to connect the tub and the detergent dispenser for transfer of the wash water stored in the tub to the detergent dispenser and for transfer of the detergent stored in the detergent dispenser to the tub.
The interpretation of retinal activity by the visual thalamus.

Sensory systems of the brain inform cortical centers about the outside world via the thalamus. Despite its central location between the sensory periphery and the primary sensory cortex, the functional role of the thalamus in sensory processing is still largely unknown. Understanding the role of thalamic circuits and their modulation by other brain areas is important for several reasons. First, in order to dissect the functional role of higher brain regions, such as sensory cortical areas, it is critical that we understand what kind of input they receive from the thalamus. The thalamus takes information from several different sensory channels, carrying different sensory features. Whether these features are simply relayed to higher centers, or perhaps recombined into new features in the thalamus, is not known. Second, as a central station in sensory processing, the thalamus is thought to gate behaviorally relevant sensory information. In addition to the input from the sensory periphery, the thalamus receives input from several other brain regions. How these inputs modulate or gate sensory information in vivo is not well understood. Finally, in the case of the visual system, an important unmet medical need is optic nerve degeneration caused by end-stage glaucoma, which leads to blindness. Here the input to thalamus is lost, yet the thalamic and cortical circuits are not severely affected. New methods to reactivate the thalamic neurons by channeling visual information directly to these neurons may help to restore some visual capability after the loss of optic nerve fibers.