SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Un committente catalano nel monastero di Santa Scolastica a Subiaco: Lluís de Prades e la cappella degli Angeli

La cappella degli Angeli in Santa Scolastica a Subiaco costituisce una testimonianza artistica assai significativa, sia per la presenza del ciclo dipinto a tema angelico, un tema iconografico raro nel contesto peninsulare di quegli anni, sia per il carattere del luogo, che ingloba una grotta alla base della fabbrica abbaziale. L’importanza dell’oratorio è legata però soprattutto alla figura del committente, il vescovo di Mallorca Lluís de Prades, che si rifugiò a Subiaco nel terzo decennio del Quattrocento, dopo aver abbandonato la fazione avignonese dello scisma, e che qui fu sepolto dopo la morte a Roma nel 1429. Studi recenti hanno già proposto significativi collegamenti tra la cappella sublacense e il mondo aragonese, ma in questa sede un rinnovato sguardo alla figura del prelato e al suo retaggio culturale rende possibile comprendere la natura di questo luogo e il significato delle pitture. Il presente studio, dunque, si concentrerà dapprima sulla vicenda biografica del vescovo tra Spagna e Italia, quindi sulla ricostruzione del tessuto delle sue relazioni politiche e culturali. Si passerà quindi ad analizzare la peculiare architettura della cappella e il ciclo dipinto dal punto di vista formale e soprattutto iconografico, e si presenteranno alcune ipotesi di lettura dei dipinti, e del luogo che li accoglie, in relazione alla figura del loro committente.
The prevalence and management of side effects of lithium and anticonvulsants as mood stabilizers in bipolar disorder from a clinical perspective

Side effects are among the most frequent reasons preventing patients from taking their medication. Although the management of side effects is an important issue in clinical practice, particularly in patients with physical comorbidities, research on clinical management of side effects is rather scattered. The aim of this article was to provide an overview on the prevalence and management of various side effects of mood-stabilizing drugs. In December 2012, we carried out a PubMed search for publications reporting side effects in patients with bipolar disorder. Naturalistic studies describing the prevalence of side effects in treatment with mood stabilizers are sparse. We describe the prevalence of neurological, gastrointestinal, metabolic, thyroid, dermatological, nephrogenic, cognitive, sexual, hematological, hepatogenic, and teratogenic side effects of lithium, valproate, carbamazepine, and lamotrigine and discuss their clinical management. There are specific strategies that aim at reducing side effects, but, to date, studies on the efficacy of these interventions are lacking. With age, the renal elimination and hepatic metabolism of drugs reduce and comedication and somatic comorbidity increase, making elderly patients particularly susceptible to side effects. Most side effects can be managed by striving for the lowest possible dose without losing efficacy by lowering the dose below the therapeutic window. Specific measurements to limit certain side effects are available and may ameliorate treatment adherence.
Psychosocial Syndemics are Additively Associated with Worse ART Adherence in HIV-Infected Individuals

Adherence to antiretroviral therapy (ART) among HIV-infected individuals is necessary to both individual and public health, and psychosocial problems have independently been associated with poor adherence. To date, studies have not systematically examined the effect of multiple, co-occurring psychosocial problems (i.e., "syndemics") on ART adherence. Participants included 333 HIV-infected individuals who completed a comprehensive baseline evaluation, as part of a clinical trial to evaluate an intervention to treat depression and optimize medication adherence. Participants completed self-report questionnaires, and trained clinicians completed semi-structured diagnostic interviews. ART non-adherence was objectively measured via an electronic pill cap (i.e., MEMS). As individuals reported a greater number of syndemic indicators, their odds of non-adherence increased. Co-occurring psychosocial problems have an additive effect on the risk for poor ART adherence. Future behavioral medicine interventions are needed that address these problems comprehensively, and/or the core mechanisms that they share.
Manganese carbonates as possible biogenic relics in Archean settings

Abstract Carbonate minerals such as dolomite, kutnahorite or rhodochrosite are frequently, but not exclusively generated by microbial processes. In recent anoxic sediments, Mn(II)carbonate minerals (e.g. rhodochrosite, kutnahorite) derive mainly from the reduction of Mn(IV) compounds by anaerobic respiration. The formation of huge manganese-rich (carbonate) deposits requires effective manganese redox cycling in an oxygenated atmosphere. However, putative anaerobic pathways such as microbial nitrate-dependent manganese oxidation, anoxygenic photosynthesis and oxidation in ultraviolet light may facilitate manganese cycling even in an early Archean environment, without the availability of oxygen. In addition, manganese carbonates precipitate by microbially induced processes without change of the oxidation state, e.g. by pH shift. Hence, there are several ways how these minerals could have been formed biogenically and deposited in Precambrian sediments. We will summarize microbially induced manganese carbonate deposition in the presence and absence of atmospheric oxygen and we will make some considerations about the biogenic deposition of manganese carbonates in early Archean settings.
Intracorporeal narratives: reading internal biology in women’s literature, 1880s-1930s

My project examines British and American women’s fiction of the late nineteenth and early twentieth centuries for its depictions of internal anatomy: organs and systems, circulatory, nervous, reproductive, and digestive. This study will make a distinctive contribution to the field of medical humanities: the development of an analytical process of body-centred reading, and new analysis of how women’s writing communicates bodily experiences and depicts the ‘intracorporeal’, narrative journeys through concealed and invisible organs. The project questions: how do visualisations of the body's insides and internal workings change through time? Does literature reflect medical developments and discoveries, for example echoing the shift from the nervous to the hormonal body? How are metaphors employed to aid us in visualising these systems and parts: the nervous system as a network of vibrating strings, hormones as postal packages or chemical messages, the sperm and egg as static and kinetic, the biological clock? My work surveys the persistent desire to find a physiological rationale, to map pain internally, even when that pain has an emotional or psychological source. I also explore how changing conceptualisations of the body interact with gendered notions of pathology and disorder. Comparing fictional texts to medical writing and advertising of the same era, I will track the development of and interaction between the medical understanding of the internal body, communication in the public realm, and exploration in literature.
Selective lysine‐specific demethylase 1 inhibitor, NCL1, could cause testicular toxicity via the regulation of apoptosis

Background Recent studies have shown that epigenetic alterations, such as those involving lysine-specific demethylase 1 (LSD1), lead to oncogenic activation and highlight such alterations as therapeutic targets. However, studies evaluating the effect of LSD1 inhibitors on male fertility are lacking. Objectives We analyzed the potential toxicity of a new selective LSD1 inhibitor, N-[(1S)-3-[3-(trans-2-aminocyclopropyl)phenoxy]-1-(benzylcarbamoyl)propyl] benzamide (NCL1), in testes. Materials and methods Human testicular samples were immunohistochemically analyzed. Six-week-old male C57BL/6J mice were injected intraperitoneally with dimethyl sulfoxide vehicle (n = 15), or 1.0 (n = 15) or 3.0 (n = 15) mg/kg NCL1 biweekly. After five weeks, toxicity and gene expression were analyzed in testicular samples by ingenuity pathway analysis (IPA) using RNA sequence data and quantitative reverse transcriptase (qRT)-PCR; hormonal damage was analyzed in blood samples. NCL1 treated GC-1, TM3, and TM4 cell lines were analyzed by cell viability, chromatin immunoprecipitation, flow cytometry, and Western blot assays. Results LSD1 was mainly expressed in human Sertoli and germ cells, with LSD1 levels significantly decreased in a progressive meiosis-dependent manner; germ cells showed similar expression patterns in normal spermatogenesis and early/late maturation arrest. Histological examination revealed significantly increased levels of abnormal seminiferous tubules in 3.0 mg/kg NCL1-treated mice compared to control, with increased cellular detachment, sloughing, vacuolization, eosinophilic changes, and TUNEL-positive cells. IPA and qRT-PCR revealed NCL1 treatment down-regulated LSD1 activity. NCL1 also reduced total serum testosterone levels. Western blots of mouse testicular samples revealed NCL1 induced a marked elevation in cleaved caspases 3, 7, and 8, and connexin 43 proteins. NCL1 treatment significantly reduced GC-1, but not TM3 and TM4, cell viability in a dose-dependent manner. In flow cytometry analysis, NCL1 induced apoptosis in GC-1 cells. Conclusions High-dose NCL1 treatment targeting LSD1 caused dysfunctional spermatogenesis and induced caspase-dependent apoptosis. This suggests the LSD1 inhibitor may cause testicular toxicity via the regulation of apoptosis.
Incident radiation and the allocation of nitrogen within Arctic plant canopies: implications for predicting gross primary productivity

Arctic vegetation is characterized by high spatial variability in plant functional type (PFT) composition and gross primary productivity (P). Despite this variability, the two main drivers of P in sub-Arctic tundra are leaf area index (LT ) and total foliar nitrogen (NT ). LT and NT have been shown to be tightly coupled across PFTs in sub-Arctic tundra vegetation, which simplifies up-scaling by allowing quantification of the main drivers of P from remotely sensed LT . Our objective was to test the LT -NT relationship across multiple Arctic latitudes and to assess LT as a predictor of P for the pan-Arctic. Including PFT-specific parameters in models of LT -NT coupling provided only incremental improvements in model fit, but significant improvements were gained from including site-specific parameters. The degree of curvature in the LT -NT relationship, controlled by a fitted canopy nitrogen extinction co-efficient, was negatively related to average levels of diffuse radiation at a site. This is consistent with theoretical predictions of more uniform vertical canopy N distributions under diffuse light conditions. Higher latitude sites had higher average leaf N content by mass (NM ), and we show for the first time that LT -NT coupling is achieved across latitudes via canopy-scale trade-offs between NM and leaf mass per unit leaf area (LM ). Site-specific parameters provided small but significant improvements in models of P based on LT and moss cover. Our results suggest that differences in LT -NT coupling between sites could be used to improve pan-Arctic models of P and we provide unique evidence that prevailing radiation conditions can significantly affect N allocation over regional scales.
Experiencing ‘an opening’

As a part of our ongoing exploration of training processes, this article asks a fundamental question that is close to the authors' heart: 'What is Yoga?'. Although this is undoubtedly a question that has no fixed and determined response, it becomes the framing through which we consider how a knowledge and daily practice of yoga might influence both the execution and readings of various body-based performance practices. The specific area of focus for this article is a consideration of yoga as a potential preparatory strategy for the development and preparation for performance art practices. Using our own relationship to Ashtanga yoga (both as practitioners and as teachers) as its base and its filter as an ad hoc training for witnessing performance art, the article focuses upon three interrelated pieces by Marina Abramovic (Marina Abramovic Presents ... as part of the Manchester International Festival, Whitworth Art Gallery, Manchester, UK, The Pigs of Today are the Hams of Tomorrow, Plymouth, UK and The Artist is Present at MoMA, New York, USA). The focus of the thesis is the idea of the ‘expert-witness’ and how expertness might develop through a body-based process, and what the implications are for the genitive vs. intuitive responses to practice as articulated in Malcolm Gladwell's concept of 'thin slicing'. Alongside this is a consideration of contemporary scholarship exploring posture practice in modern yoga pedagogy.
Design and Electrical Properties of Piezoelectric Energy Harvester for Roadway

Piezoelectric energy harvester (PEH) as a box type was fabricated in order to harvest mechanical energy imparted to roadways from passing vehicles and convert it into electricity. The PEH was composed of 72 piezoelectric cantilevers with 9 springs with elasticity stick to a bottom of the PEH. For the single piezoelectric cantilever, when a single push with approximately 5 mm displacement was incident to it, power of 0.355 mW was produced at . It is found that the power from the single piezoelectric cantilever increases when spring constant is high. We investigated power of PEH when the moving vehicle passes in it. Power was increased with increasing vehicle speed. When vehicle speed is 30 km/h, power is 20.6 mW.
Women’S labour activism in eastern europe and transnationally, from the age of empires to the late 20th century

ZARAH explores the history of women’s labour activism and organizing to improve labour conditions and life circumstances of lower and working class women and their communities—moving these women from the margins of labour, gender, and European history to the centre of historical study.
	ZARAH’s research rationale is rooted in the interest in the interaction of gender, class, and other dimensions of difference (e.g. ethnicity and religion) as forces that shaped women’s activism. It addresses the gender bias in labour history, the class bias in gender history, and the regional bias in European history. ZARAH conceives of women’s labour activism as emerging from the confluence of local, nation-wide, border-crossing and international initiatives, interactions and networking. It studies this activism in the Austro-Hungarian and Ottoman Empires, the post-imperial nation states, and during the Cold War and the years thereafter. Employing a long-term and trans-regional perspective, ZARAH highlights how a history of numerous social upheavals, and changing borders and political systems shaped the agency of the women studied, and examines their contribution to the struggle for socio-economic inclusion and the making of gender-, labour-, and social policies.
	ZARAH comprises, in addition to the PI, an international group of nine post-doctoral and doctoral researchers at CEU, distinguished by their excellent command of the history and languages of the region. Research rationale, research questions, and methodological framework were developed through an intensive exploratory research phase (2016–2017). ZARAH is a pioneering project that consists of a web of component and collaborative studies, which include all relevant groups of activists and activisms, span the whole region, and cover the period between the 1880s and the 1990s. It will generate key research resources that are available to all students and scholars, and will set the stage for research for a long time to come.
Compromised cortical bone compartment in type 2 diabetes mellitus patients with microvascular disease

Objective and design Patients with type 2 diabetes mellitus (T2D) have an increased fracture risk despite a normal or elevated bone mineral density (BMD). The aim of this cross-sectional in vivo study was to assess parameters of peripheral bone microarchitecture, estimated bone strength and bone remodeling in T2D patients with and without diabetic microvascular disease (MVD+ and MVD− respectively) and to compare them with healthy controls. Methods Fifty-one T2D patients (MVD+ group: n =25) were recruited from Funen Diabetic Database and matched for age, sex and height with 51 healthy subjects. High-resolution peripheral quantitative tomography (HR-pQCT) was used to assess bone structure at the non-dominant distal radius and tibia. Estimated bone strength was calculated using finite element analysis. Biochemical markers of bone turnover were measured in all participants. Results After adjusting for BMI, MVD+ patients displayed lower cortical volumetric BMD ( P =0.02) and cortical thickness ( P =0.02) and higher cortical porosity at the radius ( P =0.02) and a trend towards higher cortical porosity at the tibia ( P =0.07) compared to controls. HR-pQCT parameters did not differ between MVD− and control subjects. Biochemical markers of bone turnover were significantly lower in MVD+ and MVD− patients compared to controls (all P &lt;0.01). These were no significant correlations between disease duration, glycemic control (average glycated hemoglobin over the previous 3 years) and HR-pQCT parameters. Conclusion Cortical bone deficits are not a characteristic of all T2D patients but of a subgroup characterized by the presence of microvascular complications. Whether this influences fracture rates in these patients needs further investigation.
CENTURIO – Exchanging experiences, fostering interregional co-operation and strenghtening Regions’ self-development.

The CENTURIO programme, created by the Assembly of European Regions (AER) in 1994, has been successfully promoting dialogue and exchange of experience between European regions for several years. However, the enlargement of the EU in May 2004 served to illustrate that the European and global context for the regions is changing. Their growth and competitiveness depend on their capacity to develop in a sustainable way. Europe’s regions are facing major challenges and it is in response to this that CENTURIO is enlarging its networks of cooperation and intensifying its activities. CENTURIO is helping Europe’s regions to achieve sustainable development in a rapidly changing European and global context. Its key objectives are to promote the improvement of regions’ policies and instruments for regional development and cohesion; to contribute to assessing the effectiveness and impact of the EU’s regional policy; to support the implementation of the EU’s regional policy in an enlarged EU; and to support regions from new and future member states as they adapt to the demands of EU membership.
Development of the VR Visualisations offer through the design and implementation of a new product, i.e. a specialised tablet case enabling integration into various types of wheelchairs.

SA.60012(2020/X) The subject of the project is the design and launch of a new product in the form of an innovative specialised tablet case enabling integration into various types of wheelchairs, for alternative communication for people with speech dysfunction and motor disabilities (e.g. people after strokes, accidents, brain tumors, cerebral palsy, other diseases that affect the organ of speech and movement). The design and implementation of a new product is aimed at improving the quality of life of people with disabilities. Improving accessibility for the target group defined as persons with incomplete fitness, including people with severe spine injuries, lower limbs who move in wheelchairs and people with speech dysfunction, will be implemented through the introduction of a tool that will equip a rehabilitation stroller, the Applicant will implement the investment, including the design process based on the purchase of consulting services: a) the creation of the operational strategies necessary for the development of a new design project, including the development of crews for the project brief and the period of design direction; B) the development of projects and the Prototypow and testing of the new product; the inclusion of end-users in the testing process (d) advisory services for the development of a new product.
Acquisition of new foreign markets as part of EXPO 2020 for the original products of MKD Design Studio

SA.60012(2020/X) The applicant under this project will pursue the objectives indicated in the promotion programme of a general nature in connection with Poland’s participation in the World Exhibition EXPO 2020 in Dubai. The project will be implemented in the period from 01.09.2021 to 30.09.2022r. The direct consequence of its implementation will be increasing the competitive position of the company and the development of export activity to the new foreign market. The choice of the market is fully in line with the company’s expansion strategy. The subject of the project is activities that will allow the promotion of the Polish product brand through the Polish Economy Brand on the selected prospective market, i.e. the Gulf countries (United Arab Emirates). The applicant has a product that is competitive with products from the same industry on the international market. The planned scope of the project and participation in the promotion programme indicated by PARP is directly related to the intention to participate in the World Exhibition Expo 2020 in Dubai. 1.Participation in the fair as an exhibitor 2.Buying an advisory service in the field of preparation for entry into the prospective market, in connection with participation in fairs in the Gulf countries/ZEA/3.Organisation of external missions/including in the Polish-Emirate Economic Forum/4.The conduct of information and promotion activities has allowed us to identify features that may generate difficulties in entering new foreign markets, including: insufficient brand promotion, lack of experience in conducting information and promotion activities on the target market, limited knowledge of the prospective market. In order to overcome the above barriers, a number of actions are planned, the nature of which confirms the validity of the actions undertaken in the project How to finance the implementation of the project: The applicant will have private funds accumulated in the bank account, which will allow for the proper implementation of the project until the reimbursement of the incurred