SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Comparison of refractive error measurements in adults with Z-View aberrometer, Humphrey autorefractor, and subjective refraction

The aim of this study was to evaluate whether measurements obtained with the Ophthonix Z-View aberrometer (Vista, California) and a Humphrey autorefractor (Zeiss Humphrey, Dublin, California) correlate with standard subjective refraction measurements, based on visual acuity results.A retrospective data analysis was completed for 97 patients, age range 18 to 66 years, without evidence of systemic or ocular disease. All data were collected without dilation or cycloplegia. Refractive correction measurements (sphere, cylinder, axis) were converted to power vectors for analysis.Differences-versus-means plots show generally excellent agreement between the results of each instrument and subjective refraction, all r(2) > 0.77, with the Z-View consistently exhibiting less variability than the autorefractor (AR). Nonetheless, the Z-View tends to undercorrect myopia, whereas the AR tends to overcorrect myopia, with statistically significant mean differences (±SD) in spherical equivalents with respect to subjective refraction of 0.118 (±0.311) and -0.193 (±0.474) diopters (D), respectively. Both instruments tend to overcorrect astigmatism of less than -1.25 and -0.75 D, respectively, in some cases by as much as -0.87 D. Both instruments also tend to err in cylinder axis measurement for low astigmatism, often by more than 10°.The Ophthonix Z-View aberrometer is a useful objective clinical instrument that provides better accuracy than an AR, and its results can be used as a good starting point for a subjective refraction for most patients. It also measures higher-order aberrations not identified by other techniques. However, as with AR results, a spectacle prescription based solely on its measurements may not be appropriate for all patients.
Robust bidding strategy for wind power plants and energy storage in electricity markets

This paper explores a robust optimization-based bidding strategy for operating a wind farm in combination with energy storage devices in electricity markets. Through coordination with moderate capacity of energy storage, variable wind resources can be utilized in multi-time-scale electricity market operations, as opposed to being utilized only as real-time non-dispatchable energy producers. Given the inherent uncertainties in electricity market prices and available wind generator output, a robust optimization-based approach is formulated to determine the bidding strategy. Case studies on day-ahead and hour-ahead markets show that robust-optimization based bidding strategy provides computationally practical and economically efficient approach to operating wind farms and co-located storage when uncertainties are severe.
The medical schools outcomes database project: Australian medical student characteristics

Global medical workforce requirements highlight the need for effective workforce planning, with the overall aims being to alleviate doctor shortages and prevent maldistribution. The Medical Schools Outcomes Database and Longitudinal Tracking (MSOD) Project provides a foundation for evaluating outcomes of medical education programs against specified workforce objectives (including rural and areas of workforce needs), assisting in medical workforce planning, and provision of a national research resource. This paper describes the methodology and baseline results for the MSOD project.The MSOD Project is a prospective longitudinal multiple-cohort study. The project invites all commencing and completing Australian medical students to complete short questionnaires. Participants are then asked to participate in four follow-up surveys at 1, 3, 5 and 8 years after graduation.Since 2005, 30,635 responses for medical students (22,126 commencing students and 8,509 completing students) in Australia have been collected. To date, overall eligible cohort response rates are 91% for commencing students, and 83% for completing students. Eighty three percent of completing medical student respondents had also completed a commencing questionnaire.Approximately 80% of medical students at Australian medical schools are Australian citizens. Australian medical schools have only small proportions of Indigenous students. One third of medical students speak a language other than English at home.The top three vocational choices for commencing medical students were surgery, paediatrics and child health and general practice. The top three vocational choices for completing students were surgery, adult medicine/ physician, and general practice. Overall, 75.7% of medical students changed their first career preference from commencement to exit from medical school.Most commencing and completing medical students wish to have their future medical practice in capital cities or in major urban centers. Only 8.1% of commencing students and 4.6% of completing students stated an intention to have their future medical practice in smaller towns and small communities.The MSOD longitudinal project is now an established national resource that is beginning to generate significant research outputs, along with providing key information for workforce planning and policy makers. The project has now expanded to enrol New Zealand medical students.
Communication and assessment with adaptive realtime environments

Our overall objective is to provide both new brain-computer interface (BCI) technologies and an innovative business model focused on user-centered assessment and communication for persons with disorders of consciousness (DOCs). We have recently shown that present clinical tools to assess DOC are inadequate. Across different studies, up to 43% of patients who had been designated as nonresponsive (including in a vegetative state (VS) or minimally conscious state (MCS) were in fact able to communicate through new BCI systems developed for such patients. For example, patients could produce reliable changes in motor activity in the EEG when asked via headphones to imagine left hand movement or walking through the house if their father was named (the correct name). In related work, patients could produce differential responses to YES/NO/SKIP questions (based on the P300 component) by counting vibrations of one out of three different tactors placed on the body. This creates a pressing social and economic challenge to provide more accurate information about these patients’ cognitive abilities to families, clinicians and the patients themselves about their long-term options. By providing BCI-based assistive technology (AT) for communication and control, we will allow patients to not only make their own decisions but also interact with their environments, the internet and other people, fostering inclusion and accessibility. 
The main outcome will be a life-changing experience for many patients: being recognized as someone who can communicate. They will once again be able to convey their needs and desires to carers, and may influence decisions about therapy, end-of-life, living environments, long term care and use of ComAware products and services. Carers and medical staff will be able to better identify patients’ needs and provide care and help accordingly. Family and friends will again be able to communicate with someone they had been (mistakenly) told could not communicate.
Hypermutated tumors: insight into genome maintenance and cancer vulnerabilities provided by an extreme burden of somatic mutations

Mutations are the fuel of any evolutionary process, and this also applies to carcinogenesis. The advent of affordable DNA sequencing has enabled mutagenic processes in the human soma to be quantified genome-wide, revealing a striking occurrence of hypermutated tumors. They exhibit an extreme load of somatic changes, often harbouring hundreds of single-nucleotide variants and/or indels per megabase. The HYPER-INSIGHT project is organized into three objectives, which aim to take advantage of the unique opportunity provided by genome sequences of hypermutated and ultramutated tumors. In particular, this work planned in this project aims to further our knowledge on (i) the regional organization of the DNA replication and repair program in human cells, and the determinants thereof, (ii) the extent of selection which acts on somatic variants in various pathways or complexes and (iii) opportunities for selectively targeting DNA repair deficiencies that manifest as hypermutation. Methodologically, our work will employ a three-pronged approach. First, we will perform a multitude of rigorous statistical analyses that draw on the rich and still-expanding resources provided by cancer genomics consortia. Second, we will perform exome and genome sequencing, focusing on ultramutated tumors caused by specific defects in the DNA maintenance machinery. Third, the project involves conditional essentiality screens on cancer cell lines with hypermutant backgrounds. Their goal is to discover synthetic lethality relationships, useful for targeting hypermutating cells, while sparing healthy ones. In summary, one of the promises of cancer genome sequencing projects was to elucidate the mechanisms underlying mutational processes in the human soma, advancing our understanding of this important facet of cancer biology. We will work towards realizing this promise, thereby strengthening the EU’s position in the global scientific endeavour.
Computational regulatory genomics: motifs, networks, and dynamics

Gene regulation, the process responsible for taking a static genome and producing the diversity and complexity of life, is largely mediated through the sequence specific binding of regulators. The short, degenerate nature of the recognized elements and the unknown rules through which they interact makes deciphering gene regulation a significant challenge. 
In this thesis, we utilize comparative genomics and other approaches to exploit large-scale experimental datasets and better understand the sequence elements and regulators responsible for regulatory programs. In particular, we develop new computational approaches to (1) predict the binding sites of regulators using the genomes of many, closely related species; (2) understand the sequence motifs associated with transcription factors; (3) discover and characterize microRNAs, an important class of regulators; (4) use static predictions for binding sites in conjunction with chromatin modifications to better understand the dynamics of regulation; and (5) systematically validate the predicted motif instances using a massively parallel reporter assay. 
We find that the predictions made by our algorithms are of high quality and are comparable to those made by leading experimental approaches. Moreover, we find that experimental and computational approaches are often complementary. Regions experimentally identified to be bound by a factor can be species and cell line specific, but they lack the resolution and unbiased nature of our predictions. Experimentally identified miRNAs have unmistakable signs of being processed, but cannot provide the same insights our machine learning framework does. Further emphasizing the importance of integration, combining chromatin mark annotations and gene expression from multiple cell types with our static motif instances allows for increasing our power and making additional biologically relevant insights. 
We successfully apply the algorithms in this thesis to 29 mammals and 12 flies and expect them to be applicable to other clades of eukaryotic species. Moreover, we find that our performance has not yet plateaued and believe these methods will continue to be relevant as sequencing becomes increasingly commonplace and thousands of genomes become available. (Copies available exclusively from MIT Libraries, Rm. 14-0551, Cambridge, MA 02139-4307. Ph. 617-253-5668; Fax 617-253-1690.)
Modeling of specific structure crystallization coupling with dissolution

In this paper, the research framework for specific structure crystallization modeling has been proposed in which four steps are required in order to investigate the rigorous crystallization modeling by thermodynamics. The first is the activity coefficient model of the solution, the second is Solid-Liquid equilibrium, the third and fourth are the dissolution and crystallization kinetics modeling, respectively. Our investigations show that the mechanisms of complex structure formation and microphase transition can be analyzed by combining the dissolution and crystallization kinetics modeling. Moreover, the formation mechanism of the porous KCl has been analyzed, which may provide a reference for the porous structure formation in the advanced material synthesis.
[Anxiolytic and antidepressant effects of 3-oxypiridine and succinic acid derivatives in alloxan diabetes].

The effects of 3-oxypyridine and succinic acid derivatives (emoxipine, reamberin and mexidol) on affective disorders in rats with alloxan diabetes were studied. The efficiency of emoxipine, reamberin and mexidol was compared to alpha-lipoic acid, which is considered a "golden standard" in treatment of diabetic neuropathies. Emoxipine, reamberin and mexidol after seven administrations in single doses, that are equivalent to therapeutic range in humans, corrected the anxiety-depressive disorders in rats with alloxan diabetes. Unlike reamberin and alpha-lipoic acid, emoxipine and mexidol corrected the affective status concurrently with the decrease in hyperglycemia. At the same time, emoxipine outperformed mexidol in tranquilizing action (in maximal doses) but yielded mexidol in the antidepressant effect (in minimal doses).
Plant cell wall communication and remodelling: the wall watchers.

Plants, just like animals are highly developed multicellular organisms. In contrast to animal cells however, plant cells are surrounded by a rigid, carbohydrate-rich extracellular layer, the cell wall. This cell wall provides plants with mechanic support and a dynamic chemical signalling and metabolic environment. To allow for cell expansion, cell division, coordinated tissue growth and interactions with the environment, the cell wall status constantly needs to be sensed and modified. How plant cells perceive and signal their cell wall status is poorly understood. Here, I propose an integrated approach to uncover ligands for cell wall sensing receptors as well as their downstream signalling components. Specifically, my project aims to identify the ligands for two genetically validated cell wall receptor families, using a chemical biology approach. Next, we will analyse and validate the mode of ligand-receptor interaction by combining protein X-ray crystallography, quantitative biochemistry and reverse genetics in Arabidopsis. A detailed ligand-binding and receptor activation mechanism will allow us to specifically interfere with cell wall receptor function in vivo, and to assess their biological relevance for cell wall structure and its chemical properties. Using atomic force microscopy, we will then test if the receptors are distributed uniformly at the membrane or whether they are arranged in complex 'sensosomes'. Finally, we will characterize if plant cell wall receptors can directly act as mechanosensors. With defined receptor-ligand pairs and clear phenotypes at hand, we will try to uncover downstream signalling components for plant cell wall receptors and to validate our atomic models in planta. My ultimate goal would be to design and test cell wall receptor agonists and antagonists, which will represent powerful tools to alter cell wall homoeostasis in Arabidopsis, and potentially in crops.
Diagnosis and Impact of Hilar Lymph Node Micrometastases on the Outcome of Resected Colorectal Liver Metastasis

Liver resection is the only curative therapy for metastatic colorectal cancer. However, recurrence occurs in the majority of the cases. Hilar lymph node metastases occur with a high frequency but the methodology for its detection and the impact on the outcome of patients undergoing hepatectomy is still unknown.Twenty-six patients submitted to partial liver resection and systematic lymphadenectomy were studied prospectively. Lymph nodes considered negative by hematoxylin and eosin (H&E) staining were analyzed by serial sectioning and immunohistochemistry (IHC) with anti-human pancytokeratin antibody AE1/AE3. Recurrence-free and overall survivals were compared among LN groups.The mean number of dissected lymph nodes were 6.3 per patient. H&E showed microscopic involvement of LN in 2 patients and 3 patients had metastases identified only by IHC. The median follow-up was 39.3 months. Sixteen patients (61.5%) recurred after liver resection and although no statistical difference in survival was demonstrated there was a trend towards shorter recurrence-free survival among microscopic positive LN.Microscopic LN metastases may have impact in the outcome of patients submitted to curative hepatectomy. A better definition of micrometastases to LN is warranted, as though the potential benefit of hilar lymphadenectomy and chemotherapy selection by hilar lymph node status.
Yeast surface display-based microfluidic immunoassay

In this paper, we present a new microfluidic immunoassay platform, which is based on the synergistic combination of the yeast surface display (YSD) technique and the microfluidic technology. Utilizing the YSD technique, antigens specific to the target antibody are displayed on the surface of engineered yeast cells with intracellular fluorescent proteins. The displayed antigens are then used for the detection of the target antibody, with the yeast cells as fluorescent labels. Multiplex immunoassay can be readily realized by using yeast cells expressing different intracellular fluorescent proteins to display different antigens. The implementation of this YSD-based immunoassay on the microfluidic platform eliminates the need for the bulky, complex and expensive flow cytometer. To improve the detection sensitivity and to eliminate the need for pumping, a functionalized micro pillar array (MPA) is incorporated in the microfluidic chip, resulting in a detection limit of 5 ng/mL (or 1 ng in terms of amount) and enhanced compatibility with practical applications such as clinical biopsy. This new platform has a high potential to be integrated into microfluidic detection systems to enable portable diagnostics in the future.
Outdoor lean elderly assistant

The world population is ageing fast. By 2050, the global population of elderly is projected to more than double the size of 2015, reaching nearly 2.1 billion. This growth results in a growing care demand and less people to pay for it. An effective strategy to tackle the challenges of both the expected shortage of caregivers and the ever increasing healthcare expenses is needed. Disruptive innovations, ICT solutions as well as solutions from e.g. the creative sector and robotics can provide a solution to enable the elderly to live independently for longer and promote their health and physical condition. 
Studies have shown that promoting physical activity leads to healthier people and cost reductions. Unfortunately, elderly and people with mobility problems need additional care to stay active both indoors and outdoors. Robot Care Systems has found the solution for these people in the OLEA, the Outdoor Lean Elderly Assistant, a robot, disguised as a rollator and mobile scooter in one. The already existing LEA (time to market < a year) has a large number of sensors and sophisticated software solutions, offering balance support, posture correction and assistance in standing up and sitting down and many functionalities accessible through LEA’s touch screen (easy social contact, assistance in care tasks). The new outdoor variant, will additionally stimulate and support physical activities both in- and outdoors, and in general enables elderly to be more independent of care givers and being able to live longer at home.
Although preliminary research shows the potential market for the OLEA is large (14% of the general population), the OLEA can result in reducing care with 10 hours/week/patient, resulting in immense economic and social advantages, more detailed market analysis, economic viability research, technical feasibility research and user opinions are required to increase the investor readiness of this product and come up with a detailed business plan.
Preparation of nano magnetic modified bentonite materials for reclamation of coking wastewater

In view of the difficult separation problem of powder bentonite from solution in water treatment, the development of new type magnetic bentonite composite materials was studied. The adsorption performance of natural bentonite was improved by organic modification. The bentonite was magnetic modified by nano Fe 3 O 4 which was prepared by coprecipitation method. This magnetite composite materials which combined by bentonite and Fe 3 O 4 not only has a better adsorptive capacity for COD and a better separate effect, but also has a simple preparation technology and reaction conditions. This composite materials have been characterized by powder X-ray diffraction (XRD), Scanning electron microscopy (SEM) and Fourier transform infrared spectroscopy (FTIR). The results revealed that interlamellar spacing of bentonite was increased through organic modification and Fe 3 O 4 particles occured on the surface of bentonite particles and formed magnetic aggregation. These nano-magnetic modified materials with super performances would be used to treat coke wastewater.
Diseño de un barco de cabina accesible para uso en silla de ruedas

SA.60012(2020/X) El tema del proyecto será el desarrollo de un barco de cabina para su uso en sillas de ruedas y discapacidades motoras. El producto se preparará para las necesidades específicas de las personas con discapacidad, ergonomía y seguridad de uso. En primer lugar, se desarrollará una estrategia de diseño para identificar los parámetros necesarios resultantes de la normativa y las necesidades. Se llevarán a cabo consultas entre los destinatarios destinatarios, que se trasladarán en sillas de ruedas. Los métodos de fabricación existentes, expertos y diseñadores serán seleccionados para garantizar la correcta implementación del proyecto. Como parte del trabajo de diseño, diseño y ejecución se desarrollarán directrices sobre materiales y métodos de fabricación. El proyecto se analizará para cumplir con los objetivos establecidos en la estrategia. Se realizará un prototipo de la embarcación de cabina, que será probado por probadores — personas con movilidad reducida en términos de ergonomía de uso y seguridad. Como parte de la consultoría de implementación, se seleccionarán los medios de producción adecuados y los métodos de comercialización del proyecto. Como parte de la inversión inicial, se comprarán dos máquinas de soldadura, una prensa y una máquina de doblado hidráulica. Se ubicarán en una sala de nueva construcción ubicada en las inmediaciones del río Vístula.
STRATEGIC PLANS FOR RESTORATION, PROTECTION & ECO TOURISM PROMOTION IN NATURA 2000 SITES WHICH DEVASTATED BY NATURAL DISASTERS 

The main objective of the project is the post-fire conservation of the protected partner areas through a combination of integrated areas management and promotion of ecotouristic development. The expected outputs include: • forest and wetlands habitats maps • studies on post-fire effects in biodiversity • management plans on the restoration and improvement of biodiversity • a Geo-database and a specialized GIS • a common Decision Support System based on this Geo-database v ecotourist paths and informative boards planned, realized and mapped through GIS • 4 Sustainable tourism management plans • 1 Multilingual eco-tourist guide • a joint exhibition for “Nature & Culture