SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Regeneration and zonation by zeb2 of liver endothelium

The liver is a crucial organ in metabolism and removal of waste products from the body. Hereto, the liver parenchyma receives a mix of nutrient-rich blood from the portal vein and oxygen-rich blood from the hepatic artery. Blood flows through the sinusoids and leaves the liver via the central and hepatic veins. Hepatic sinusoids are highly specialised channels in which hepatocytes are organised in zones according to their position relative to the portal and central veins. They are lined with a specified, fenestrated, discontinuous endothelium. Many drugs (e.g., chemotherapeutics) and toxins cause damage to the sinusoids that may lead to liver fibrosis and cirrhosis. Formation of new sinusoids is an indispensible step for liver regeneration. Furthermore, liver sinusoidal endothelial cells (LSECs) produce agents that stimulate hepatocyte proliferation. Time-dependent expression of different proteins in the developing liver is important for sinusoid formation. The host lab found that the transcription factor Zeb2 (also known as Sip1) is highly expressed in LSECs in the developing and adult liver. Furthermore, its expression in adult LSECs is mainly in those from the pericentral zone. We hypothesize that Zeb2 is a transcriptional determinant of LSEC specification, zonation, maintenance and regeneration. Here, we aim to: (i) evaluate whether/how Zeb2 contributes to LSEC specification and zonation; (ii) establish a role for Zeb2 in LSECs in adult mice; (iii) assess its role in sinusoidal regeneration during liver disease; and (iv) estimate the therapeutic potential of Zeb2-treated endothelial progenitors in recovery from liver injury. To address these aims, we will use a multidisciplinary approach based on lentiviral overexpression in cultured ECs, transgenic mice lacking or overexpressing Zeb2 in ECs and transplantation of ECs pre-specified towards LSECs. These studies will allow us to evaluate the potential of Zeb2 as a novel target to stimulate liver regeneration.
The dynamics of resource conflict: Lessons from Nigeria and Malaysia

Since the emergence of environmental resource conflict on the international political discourse in the early 1980s, there has been growing concern that, resource conflicts in developing countries is likely to exacerbate conflicts originating in strenuous struggles over scarce resources due to population increase. The apparent manifestation of conflicts in the oil rich Niger Delta region in Southern Nigeria and Farmer-herder conflicts in Northern Nigeria to the lingering forest logging controversy in Malaysia is an upsurge of the coming resource “crisis” in these countries. The focus of this paper is to discuss issues on management of resource conflicts in developing countries like Nigeria and Malaysia. The paper suggests that, there is the need for commitment from the states and all stakeholders through institutionalization of proactive conflict resolution and peace building strategies, instead of resolution through the grave yards. Discussions are based on secondary data with examples from recent experiences from farmer-herder conflict, and Niger Delta crisis in Nigeria, and forest logging in Malaysia.
Nitec: a negative ion time expansion chamber for directional dark matter search

The goal of this project is the construction of a Negative Ion Time Projection Chamber (NITPC) with triple Gas Electron Multiplier amplification and pixel readout (GEMPix) for directional Dark Matter (DM) searches. DM is 5 times as prevalent as normal matter in the Universe, but its identity remains unknown. Its mere existence implies that our inventory of the basic building blocks of nature is incomplete: deciphering its nature is one of the most compelling tasks for fundamental physics and astronomy. Weakly Interacting Massive Particles (WIMP) are well motivated DM candidates, independently predicted by Standard Model extensions and Big Bang cosmology. Direct detection experiments aim at observing very low energy (10-100 keV) nuclear recoil of WIMP scattering in the matter. While today leading experiments have managed to reach excellent rejection for electromagnetic components, other background sources (such as neutrinos and environmental radioactivity) will forbid to even think larger mass next-generation detectors without a drastic change in technology. We believe that the combination of the large volumes and improved position and energy resolution provided by the negative ion technique, together with the excellent performances of the GEMPix can offer a significant contribution to this research field. In a NITPC, negative ions drift rather than free electrons, drastically reducing diffusion thanks to their higher mass. This is why we want to combine for the first time this idea with one of the most advanced readout, the GEMPix: a triple GEM detector coupled to a Medipix ASIC board, able to provide excellent spatial, energy and time resolutions. Its sensitivity to single ionization cluster will allow this NITPC, together with the slow motion of the anions, to function effectively as a Time Expansion Chamber, hence NITEC. It's worth noticing how NITEC could work also as neutrinoless double beta decay detector, X-ray polarimeter and microdosimeter for hadrotherapy.
GREEN-skiLls for a sustAiNable Development

The Mediterranean area suffers from extremely high rates of youth and female unemployment. To face this challenge, GREENLAND promotes social inclusion and fight against poverty by providing unskilled and underprivileged young people with marketable skills in the Green and Circular Economy, with the potential to generate thousands of jobs. To reach its objective, the project will create new curricula based on market needs, skills transfer to NEETs and women, media-based training tools, and cultural exchanges among young people. The creation of new employment opportunities will be reinforced by the sector-skills alliances between TVETs and SMEs.
Développement d’un nouveau service compétitif par la mise en œuvre de travaux de recherche et d’éco-innovation dans la société PPHU Jawoplast IMPORT- EXPORT DOROTA JAWORSKA

L’objectif du projet est d’accroître la compétitivité de PPHU Jawoplast IMPORT-EXPORT DOROTA JAWORSKA sur le marché automobile en mettant en œuvre l’innovation de processus et de produits résultant de sa propre recherche et développement. En raison d’un nouvel investissement conduisant à la diversification de la production de l’entreprise par la mise en œuvre d’une technologie innovante de peinture automobile, l’offre de la requérante apparaîtra complètement nouvelle. Pour que l’innovation soit couronnée de succès, elle doit être commercialement attractive et peut être mise en œuvre dans les conditions technologiques d’une usine de production donnée. Cet objectif est identique à l’objectif principal de la mesure 3.3 du ROP WM: Utilisation accrue de l’innovation dans les entreprises du secteur des PME — et l’objectif principal du ROP WM: Un développement intelligent et durable renforçant la cohésion sociale et territoriale, en exploitant le potentiel du marché du travail mazovien. Le projet conduit à l’élargissement de la portée de l’activité de la requérante, y compris à l’augmentation de l’emploi, au niveau technologique et organisationnel et au développement de la coopération dans les domaines économique et scientifique. L’achat d’équipements modernes affectera directement le développement de l’entreprise et la compétitivité de Mazovia dans le système européen — l’équipement est la dernière technologie — en Pologne — l’avis sur l’innovation. Il en va de même pour la recherche en cours. Grâce à la mise en œuvre de la recherche, nous renforcerons les capacités de recherche de la région et contribuerons ainsi à la réalisation des indicateurs décrits dans la stratégie Europe 2020. (il y aura un transfert de technologies innovantes vers la région de Mazovie.) La mise en œuvre de technologies innovantes et l’introduction sur le marché de nouveaux services en corrélation avec les nouveaux emplois et la formation des travailleurs répondent aux objectifs de la nouvelle stratégie Europe 2020 en matière de lutte contre le chômage, de mise en œuvre des connaissances les plus récentes et de technologies innovantes.
A progressive transmission strategy for GIS vector data under the precondition of pixel losslessness

It is well known that the final results of geographic information system (GIS) mapping are composed of rasterized pixels in most display devices. Based on this, pixel equivalence is proposed as two vector data that can produce the same raster image on a device under the same mapping processes and parameters. Moreover, if between the two data, one is considered the original data and the other is its reduced-quantity version, then the latter can be regarded as pixel losslessness relative to the former. In this case, the reduced-quantity version can be used instead of the original data to produce the same result from the perspective of visualization. The aim of this article is to explore how to produce the transmitted data, including an initial code and a series of increments that are used for progressive transmission, to retain pixel losslessness. By illustrating that the vector data can be represented by a vertex or ordered sequence of vertices, this article introduces the detailed concepts of pixel equivalence and pixel losslessness of vector data. Then, the requirements for pixel equivalence between two vertices are deduced by analyzing the coordinate transform processes under specific assumptions. The method to generate an initial code and a series of increments related to a single vertex is proposed to produce vertices that are pixel equivalence to the original vertex under different coordinate transform processes. By discussing the traversing mode of the ordered sequence of vertices based on quadtree cells, a coding algorithm is proposed to develop the progressive transmission related to the multi-vertex and to generate reduced-quantity versions to retain pixel losslessness. Finally, experiments are designed to demonstrate that, under the precondition of pixel losslessness, the proposed progressive transmission method can significantly reduce the amount of transmitted data in the network environment.
Personalized, bio-engineered skin grafts for the permanent treatment of skin defects.

Every year in the world, more than 50M patients suffer from skin defects (e.g. burns, excision, etc.) and need surgical intervention to restore skin function. Standard of care, skin autografting, very often leaves these patients with scars. Scars are permanent and disfiguring, and can also be painful and highly debilitating. Indeed, they may also impair movement and growth, and require several follow-up surgeries, intense homecare and psychosocial rehabilitation. Hence, scars significantly affect patient’s quality of life, along with the economic burden for the health-care system. Furthermore, in the case of large wounds, donor site shortage represents a real clinical issue. denovoSkin™ is a patented, personalized, bio-engineered human skin graft classified as Advanced Therapy Medical Product (ATMP). It is engineered in large quantities starting-off from a stamp-sized skin biopsy of the patient, thus solving the donor site shortage issue. Moreover, because of its dermo-epidermal structure, denovoSkin is expected to minimally scar after transplantation. Its outstanding performance could considerably reduce or even avoids further corrective interventions, allowing for considerable savings in terms of costs. denovoSkin™ is granted with Orphan Drug Designation for the treatment of burns by Swissmedic, EMA and FDA. So far, more than €14M have been invested over the last 16 years of research into the development and the clinical testing of denovoSkin™. To have denovoSkin™ fully projected at a European and global level we need a further investment of €3.57M to set up a solid EU value chain able to meet the large demand expected during the commercialisation via developing the automation of manufacture. The proposed work in Phase 1 of the SME instrument fits into our overall plan to reach the market by contributing the financial resources needed to plan a fast sound wider deployment of denovoSkin™ and its market uptake.
METHOD OF IDENTIFYING A DATA STRUCTURE REPRESENTATIVE OF A CONSUMPTION OF FLUID, CORRESPONDING DEVICE AND COMPUTER PROGRAMME

The invention relates to a method of identifying an item of equipment carrying out a consumption of a fluid, the consumption being characterized by a unitary consumption segment called a lineament comprising a list of contextual and morphological parameters. According to the invention the method comprises: - a plurality of steps of obtaining (10) data representative of a morphological score (SM) of said lineament (LIN) as a function of at least one value of at least one morphological descriptor (D) of the lineament (LIN) and of at least one category of equipment (CE), delivering a list comprising at least one morphological score (LSM); - a plurality of steps of obtaining (20) data representative of a contextual score (SC) of said lineament (LIN) as a function of at least one value of a contextual descriptor (C) of the lineament (LIN) and of a mean quantity of fluid consumed (QFMC) over at least one time period, delivering a list comprising at least one contextual score (LSC); - a step of identifying (30) an equipment category (C) and/or an item of equipment giving rise to said lineament (LIN) as a function of the scores of said list of morphological scores (LSM) and of said list of contextual scores (LSC).
Vouchers inovadores no projeto BENEKOVterm s.r.o. — Projeto A

A BENEKOVterm s.r.o. é uma das principais empresas europeias que lida com a questão da queima de combustíveis sólidos e biomassa. Seus produtos são usados para aquecimento de mais de 30, edifícios em mais de 30 países em todo o mundo. O projeto de vales inovadores proposto baseia-se em atividades de investigação conjuntas, com uma instituição de investigação, com especial incidência nos serviços de ensaio e na subsequente certificação da série de caldeiras de água quente para lenhite e péletes de madeira.
Medical Mockup Modelling

The MMM project aims to create 3D medical mockups starting from 2D images that come from hospitals. The first focus will be on the circulatory system with particular attention to the heart. The creation of CRM and CSM is envisaged for the encrypted management of data, information and images and the development of a laboratory dedicated to the study of materials and printing techniques to be able to then assemble new mockups based on specific requests. Finally, a web platform will be created for information exchange.
VARIABLE GAS SUBSTITUTION FOR DUAL FUEL ENGINE AND METHOD

A system having an internal combustion engine connected to a driven device includes primary and secondary fuel supplies. A primary fuel supply sensor is configured to provide a primary fuel supply signal indicative of a rate of supply of a primary fuel to the engine through the primary fuel supply. A secondary fuel supply sensor is configured to provide a secondary fuel supply signal indicative of a rate of supply of a secondary fuel to the engine through the secondary fuel supply. A power output sensor measures a parameter indicative of a power output of the driven device and provides a power output signal. An electronic controller receives the primary and secondary fuel supply signals and the power output signal, and determines a characteristic of the secondary fuel based on the primary and secondary fuel supply signals and the power output signal.
Lunar meteorite Yamato-983885: Noble gases, nitrogen and cosmic ray exposure history

Abstract Noble gases and nitrogen have been in lunar meteorite from antartcica: the polymict regolith breccias, Yamato-983885 (hereafter Y-983885). Y-983885 has highest concentration of trapped noble gases (Ar, Kr, and Xe) among all the lunar meteorites and returned lunar samples. Noble gases and nitrogen abundances measured in two samples of the lunar meteorite Y-983885. The concentration of trapped noble gases in Y-983885 (A) are, 20Ne=3.69×10−3, 36Ar=12.6×10−4, 84kr=8.57×10−7 and 132Xe=1.63×10−7 ccSTP/g. The cosmic-ray exposure ages for Y-983885 are thus calculated to be T21 (A)=1592±232 Ma and T21 (B)=574±85 Ma for 2π geometry (using production rates as per Hohenberg et al., 1978 and bulk composition ). The exposure ages of samples A and B differ, indicating that they have undergone different exposure scenarios on the lunar surface. The different irradiation ages (T21 (A)=1592±232 Ma and T21 (B)=574±85 Ma) indicates that the regolith material which constitutes the meteorite Y-983885 resided at different shielding depths on lunar surface before agglomeration into the final meteorite. Exposure ages calculated using end member compositon like norite, basalt, tractolite (1947 to 1365 and 711 to 455 for A and B respectively) indicates clearly that the two samples A and B has undergone different exposure on Moon. The 20Ne/22Ne ratio of 13.60±0.01 in temperature step 400 °C of Y-983885 (A) demonstrate a clear retention of solar wind signature in this meteorite. The presence of high contents of trapped solar wind gases indicates that Y-983885 consists of mature lunar regolith material. Variable amounts of solar gases as well as cosmogenic noble gases indicate that Y-983885 (A and B) is compacted from several fragments that were exposed at the surface and/or at various depths in the regolith, before becoming part of Y-983885.
Lung Cancer Assistant: a hybrid clinical decision support application for lung cancer care

Multidisciplinary team (MDT) meetings are becoming the model of care for cancer patients worldwide. While MDTs have improved the quality of cancer care, the meetings impose substantial time pressure on the members, who generally attend several such MDTs. We describe Lung Cancer Assistant (LCA), a clinical decision support (CDS) prototype designed to assist the experts in the treatment selection decisions in the lung cancer MDTs. A novel feature of LCA is its ability to provide rule-based and probabilistic decision support within a single platform. The guideline-based CDS is based on clinical guideline rules, while the probabilistic CDS is based on a Bayesian network trained on the English Lung Cancer Audit Database (LUCADA). We assess rule-based and probabilistic recommendations based on their concordances with the treatments recorded in LUCADA. Our results reveal that the guideline rule-based recommendations perform well in simulating the recorded treatments with exact and partial concordance rates of 0.57 and 0.79, respectively. On the other hand, the exact and partial concordance rates achieved with probabilistic results are relatively poorer with 0.27 and 0.76. However, probabilistic decision support fulfils a complementary role in providing accurate survival estimations. Compared to recorded treatments, both CDS approaches promote higher resection rates and multimodality treatments.
BIDET-SHOWER AND METHOD FOR CLEANING THE INTIMATE AREA OF A USER

The invention relates to a bidet-shower for feeding water to the intimate area of a user, comprising a water supply and a hose connected to the water supply for conducting a flow of water from the water supply to the user, in particular to a shower head of the bidet-shower, the shower head being connected to the hose, characterized in that the bidet-shower has a device for introducing additives into the flow of water, which is arranged between the water supply and the hose.
Effects of Memantine on Visual Functions after Scleral Buckling for Retinal Detachment

Purpose: Evaluating the effects of memantine on visual function after scleral buckling for rhegmatogenous retinal detachment (RRD) Methods: In a Double blind prospective randomized clinical trial, 61 patients with clinical diagnosis of less than 4 weeks macula-off RRD who had successful scleral buckle surgery had been selected and divided into two randomized groups. Thirty of them received 5 mg/day memantine orally for first week and 10 mg/day for two weeks, while the others (31 patients) received placebo. Best corrected visual acuity (BCVA), macular thickness measured by optical coherence tomography (OCT) and contrast sensitivity test, were measured for all patients at one and three months. Multifocal electroretinography (ERG) was performed for all patients who returned to us at third month postoperatively. Results: Mean BCVA was 0.74±0.27 logMAR in memantine group versus 0.77±0.21 logMAR in placebo group at one month, and improved respectively to 0.64±0.25 logMAR versus 0.69±0.26 logMAR in memantine and placebo groups. There wasn't significant difference in first month and third month BCVA between two groups. Mean central macular thickness in memantine group was significantly lower than placebo group 215±41 µm versus 262±101 µm at first month, respectively and this difference was also significant after three months 204±39 µm versus 249±57 µm. Nineteen of 61 patients (31.4%) had persistent subretinal fluid (SRF) at first month (12 of them were in placebo group). P1 wave amplitude of multifocal ERG in 10-15o and >15o of central fovea in memantine group were significantly higher than placebo group.
A METHOD FOR ENCAPSULATING ADDITIVES INTO SEEDS, BEANS, CEREALS AND NUT KERNELS

The present invention discloses the use of supercritical carbon dioxide for injecting additives to seeds and kernels.
Web User Opinion Analysis for Product Features Extraction and Opinion Summarization

Selling the product through Web has become more popular because of online shopping. This enables merchants to sell their products through Web and expectsthe customer to express their opinion through online about the product which they have purchased. Due to this we find number of customer reviews on a particular product, it varies from hundreds to thousands, for some product it is more than that. In order to help the customer and the manufacture/merchant we propose a semantic based approach to mine different product features and to find the opinion summarization about each of these extracted product features by means of web user opinion expressed through th e customer reviews using typed dependency relations .
METHOD OF HEAT DRILLING OF HOLES IN ICE AND APPARATUS FOR CARRYING OUT THE METHOD

The major field of application of drilling in ice is polar research with through-bores in floating ice for examining the lower surface of the ice, the water below it and the bottom of the sea. Melt drill heads or wash drill heads operating wi th hot water are used for heat drilling which, however, can only wash out bore hole diameters in the range of he diameter of the drill and. Therefore, render th e lowering and hoisting of drills and measuring apparatus very difficult. For forming uniform and large bore diameters the method in accordance with the invention, therefore, provides a combination of the melt drill and the wash drill, wash drilling taking place in the radial plane of the bore hole, and for thi s purpose uses a melt-wash drill head (1) which at its top is provided with a water inlet (2), a hemispherical melt section (3) below and a narrow azimuthally circumferential annular gap (5) connected by large surfaces with the water inlet (2), through which gap (5) the hot water (4) is guided against the wall (7) of the bore hole and deflected upwardly so that a smooth surface (14) of the bore hole and a constant bore hole diameter (15) result. The melt-wash drill head (1) closes a pilot bore hole (9) with a film (12) of melt water to prevent cold sea water from being sucked in atthe end of the main bore hole (19).