SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Waste management normative update and practices in the cross-border Italian-Slovenian coastal area

The project consists in a course on waste regulations and management in the Italian- Slovenian coastal area from Duino-Aurisina to Piran-Pirano. Both in Italy and in Slovenia the need exists to develop the professional skills of public administration staff regarding mutual awareness of existing legal provisions, forms and paperwork required by the neighbouring Country, and the structure of the institutional entities charged with the management of environmental waste-related issues. The project aims therefore to bring together in the same classroom several employees of the municipalities located along the coastal line between Duino-Aurisina to Piran-Pirano. The technical contents of the course are related to the future creation of a cross-border network in the field of waste and environmental management, that could be implemented once the interested administrations have identified which operations can be carried out according to local, regional, national and European legislation. The subjects discussed include an analysis - both for the Italian and the Slovenian side - of the legal framework on waste management as well as the planning of waste management; the roles and competences of relevant bodies and organisations; the technical requirements for waste disposal/recovery/management (urban and special waste alike) on the territory. The course ends with the creation of a working group that will continue to work on the issues of waste disposal and environmental management.
Role of non-phagocytic, lymphocyte-like haemocytes in the antiviral and antibacterial defence of shrimp

Shrimp (Penaeus vannamei) aquaculture industry is the fastest-growing sector of the global aquaculture is threatened worldwide by viral diseases, of which White Spot Syndrome is the most harmful and bacterial diseases, of which Vibriosis is the most damaging. Therefore, appropriate biosecurity and management measures in shrimp aquaculture are important in preventing diseases. Stimulating the immunity in shrimp is another factor that can help shrimp in surviving infectious attacks. Although the immune system of invertebrates has been well studied in insects, much less information is currently available for crustaceans. The general concept in a crustacean is that there are three types of haemocytes in the circulating haemolymph, but recent research in the laboratory of Prof. Dr Hans Nauwynck indicated that the haemocytes of P. vannamei can be separated in five distinguished subpopulations, of which two subpopulations were previously not described. The cells of these two subpopulations resemble mammal lymphocytes and are therefore designated lymphocyte-like haemocytes (LLHs). Against this background, it is paramount to investigate the immunological function of these LLHs in depth. ShrimpLLH project objectives are (i) to isolate, (ii) to characterize and (iii) to analyze the immunological functions of haemocyte subpopulations. This project will further fill the knowledge gap in shrimp immunity, more specifically, it will provide information on the immunological role of LLHs. Since this project is multidisciplinary, it will increase the competence of the candidate in advanced immunological techniques and experience in crustacean innate immunity research. The new knowledge gained in this project will facilitate to develop a technique to screen products that can aid the shrimp haemocytes in their fight against different infectious diseases. ShrimpLLH project is in line with the EU strategy for the development of sustainable aquaculture.
Childhood presentation of COL4A1 mutations

To describe the clinical and radiological features of four new families with a childhood presentation of COL4A1 mutation.We retrospectively reviewed the clinical presentation. Investigations included radiological findings and COL4A1 mutation analysis of the four cases. Affected family members were identified. COL4A1 mutation analysis was performed in all index cases and, where possible, in affected family members.The three male and one female index cases presented with recurrent childhood-onset stroke, infantile hemiplegia/spastic quadriplegia, and infantile spasms. Additional features such as congenital cataracts and anterior segment dysgenesis were present. Microcephaly and developmental delay/learning difficulties were present in three cases. Three cases had one or more family member affected in multiple generations, with a total of 11 such individuals identified. The clinical features showed a wide intrafamilial variation. Magnetic resonance imaging (MRI) showed bilateral white matter change in all cases, except in one mutation-positive family member. Unilateral or bilateral porencephaly was present in cases with infantile hemiplegia, and a diagnosis of clinical stroke was supported by the presence of intracerebral haemorrhage. The age at diagnosis was between 1 year and 6 years for the children with presentation in infancy and 12 months after stroke in a 14-year-old male. Three new pathogenic mutations were identified in the COL4A1 gene.COL4A1 mutations can present in children with infantile hemiplegia/quadriplegia, stroke or epilepsy, and a motor disorder. The presence of eye features and white matter change on MRI in childhood can help point towards the diagnosis. Once the diagnosis is made, a careful search can identify affected family members.
Dutch elm disease and elm bark beetles: a century of association

Abstract: Bark beetles of the genus Scolytus Geoffroy are the main vectors of the fungus Ophiostoma ulmi s.l., which causes the Dutch elm disease. The large and small elm bark beetles - S. scolytus (F.) and S. multistriatus (Marsham), respectively - are the most common and important species spreading the pathogen worldwide. The success of the pathogen-insect interactions is mainly due to the characteristic reproductive behavior of the elm bark beetles, which, however, largely depends on the occurrence of infected trees. During feeding activity on elm twigs, callow adults carrying pathogen conidia on their bodies contaminate healthy trees and facilitate pathogen development and movement within the wood vessels. Infected trees become then suitable for insect breeding in the stem bark. This well-known mutualistic association has devastating consequences for elm survival. Although much is known about insect-pathogen interactions and transmission mechanisms, many topics still deserve additional attention, as, for example, beetle systematic based on new molecular tools and morphological characters; selection of European elm clones based on disease avoidance; consequences of global warming on life-history of the three organisms (fungus-insect-tree) involved in the pathosystem; new problems resulting from the rapid increase of international trade among continents, leading to the accidental introduction of new vector species or new pathogen species or races, or to the introduction of new highly susceptible elm species in gardens and public parks. A holistic approach to tackle the problem is highly recommended, taking into account how these organisms interact with each other and the environment, and how their interactions could be modified in order to face one of the most destructive diseases ever known in plant pathology.
The involvement of nurses in clinical echocardiography

Abstract Echocardiography is a basic examination in cardiology used to assess the anatomy and function of the heart. An echocardiography nurse is a health care specialist who is able to use echocardiographic equipment to obtain images of the heart. Standards for echocardiography personnel vary widely between countries. In the Czech Republic, there is no training program for nurses to carry out echocardiograms and the work is done almost exclusively by physicians. In many other countries, including the United Kingdom and the USA, specialist nurses carry out and report echocardiograms independently. In this article, we compare requirements for echocardiography nurses in different countries.
Tuning electronic properties in twisted 2d transition metal dichalcogenides heterostructures.

The emergence of graphene in 2004 gave rise to the isolation of a new  myriad of 2D materials with many different properties. In addition, the stacking of different 2D layers, forming Van der Waals heterostructures,  has shown the possibility to modify and expand the features of the final hybrid materials. An important ingredient for the final attributes of these heterostructures is the alignment of its constituents. As a consequence of the difference in lattice constant and the relative angle between the 2D layers, a moiré pattern arises. This moiré pattern can give rise to new physics not present in the original materials. This has already being proven in twisted graphene heterostructures, and its study is exploding in popularity these days.
On the other hand, twisted heterostructures of semiconducting TMDs have received less attention. This project aims to realise and understand new correlated electronic phases of matter in twisted heterostructures of atomically thin semiconductors. Specifically, the project aims to: (1) thoroughly characterize the electronic structure of twisted semiconductor heterostructures; (2) understand how correlated electronic phases arise from interactions in twisted semiconductor heterostructures; and (3) search for new electronic phases such as spin liquids and topological phases. These new electronic phases will radically alter the conductivity of the heterostructure, and are expected to be highly sensitive to the electron density in the moiré superlattice and hence can be tuned via electronic gates, creating novel low-energy switches. The heterostructures will be characterised using electronic measurements, and low temperature scanning probe microscopy and spectroscopy measurements. While this fellowship would allow the experienced researcher to learn new techniques and expand his knowledge and networks, the topic of this proposal is also in line with the goals of Horizon 2020, Graphene Flagship and Quantum Flagship EU programmes.
Simultaneous release of peptides and phenolics with antioxidant, ACE-inhibitory and anti-inflammatory activities from pinto bean (Phaseolus vulgaris L. var. pinto) proteins by subtilisins

Abstract Production of novel functional ingredients from legume proteins is a valuable strategy to boost their food use and intake. Aimed at a better exploitation of the functional properties of pinto bean hydrolysates, the effectiveness of two subtilisins (Alcalase and Savinase) for the simultaneous release of bioactive peptides and phenolics with antioxidant, angiotensin I converting enzyme (ACE) inhibitory and anti-inflammatory activities was investigated. A higher proteolytic efficiency was observed for Alcalase that increased the concentration of small peptides in hydrolysates after 120 min. Savinase improved hydroxycinnamic acids and flavonoid contents in hydrolysates after 90 min due to its higher esterase activity. The most active hydrolysates combined potent free radical scavenging (326–348 mmol TE/g), ACE inhibitory (IC 50  = 0.22–0.26 mg/mL) and anti-inflammatory (28–16% inhibition) activities. Peptide characterization of active hydrolysates confirmed the presence of bioactive fragments derived from phaseolin. These results evidence the promising potential of pinto bean hydrolysates as functional ingredients in the design of healthy foods.
NMR Crystallography as the state-of-art tool for insight into structural properties of active pharmaceutical ingredients and their formulations – Innovative methodology to improve the quality of medical products.

The aim of this project is to develop methodology of analysis active pharmaceutical ingredients (APIs) and their formulation to precisely describe structural behaviours existing in their solid-state forms. The extensive study will consider NMR Crystallography as the perfect tool for solving problems of polymorphism, solvatomorphism and/or effect of co-crystallisation. For selected investigating objects, attempt will be made also to answer the question of influence of excipients and manufacturing procedure on API. Since the neurodegeneration and collaborative diseases became one of the main problems for the elderly people, this work will focus on the medicines designed in the last decade for treatment of that diseases, such as Parkinson, Sclerosis Multiplex, Schizophrenia or Dementia. Finally, our study not only allows to get important structural information for particular objects but also promises to extend capability of innovative methodology to improve the quality of medical products.
Comparison of Different Finite Element Models for the Transient Dynamic Analysis of Laminated Glass for Structural Applications

Commercial laminated glass is usually composed of two glass layers and an interlayer of PVB. The viscoelastic behaviour of the PVB layer has to be taken into account when dealing with dynamic loads. This paper shows different Finite Element (FE) models developed to characterize laminated glass. Results are contrasted with data from different reference test cases. First, a quasi-static test is reproduced with a 2d model through a transient analysis. In addition, flexural modes of vibration in a free-free test configuration have been analysed using 2d as well as 3d FE models. Apart from using transient analysis in order to simulate the dynamic behaviour of laminated glass, an iterative procedure has been employed which permits to identify the correct value of the shear modulus of the PVB layer for each mode in an eigenvalue analysis.
Heparanase Stimulates Chondrogenesis and Is Up-Regulated in Human Ectopic Cartilage

Hereditary multiple exostoses is a pediatric skeletal disorder characterized by benign cartilaginous tumors called exostoses that form next to growing skeletal elements. Hereditary multiple exostoses patients carry heterozygous mutations in the heparan sulfate (HS)-synthesizing enzymes EXT1 or EXT2, but studies suggest that EXT haploinsufficiency and ensuing partial HS deficiency are insufficient for exostosis formation. Searching for additional pathways, we analyzed presence and distribution of heparanase in human exostoses. Heparanase was readily detectable in most chondrocytes, particularly in cell clusters. In control growth plates from unaffected persons, however, heparanase was detectable only in hypertrophic zone. Treatment of mouse embryo limb mesenchymal micromass cultures with exogenous heparanase greatly stimulated chondrogenesis and bone morphogenetic protein signaling as revealed by Smad1/5/8 phosphorylation. It also stimulated cell migration and proliferation. Interfering with HS function both with the chemical antagonist Surfen or treatment with bacterial heparitinase up-regulated endogenous heparanase gene expression, suggesting a counterintuitive feedback mechanism that would result in further HS reduction and increased signaling. Thus, we tested a potent heparanase inhibitor (SST0001), which strongly inhibited chondrogenesis. Our data clearly indicate that heparanase is able to stimulate chondrogenesis, bone morphogenetic protein signaling, cell migration, and cell proliferation in chondrogenic cells. These properties may allow heparanase to play a role in exostosis genesis and pathogenesis, thus making it a conceivable therapeutic target in hereditary multiple exostoses.
Measuring value‐leverage in aerospace supply chains

Purpose – The traditional value chain has changed under the influence of globalisation, lean thinking and the value leverage towards suppliers in the supply chain. The leverage of value by the focal original equipment manufacturer (OEM)‐company to the supply chain has caused the focal OEM‐company to transform into a large‐scale system integrator (LSSI). The LSSI was defined according to the Petrick's definition. Indicators that measure the value‐leverage by these LSSI companies have not been found in literature. The purpose of this paper is to describe indicators that measure value‐leverage and illustrates that LSSI companies in the aerospace industry have a value‐leverage capability, using these indicators.Design/methodology/approach – The authors' main research question is: “How to measure value‐leverage by LSSIs in the aerospace industry?”. As value‐leverage indicators have not been studied before, a literature study was carried out to develop a set of indicators which were tested in a quantitative ana...
Surface remuneration of concrete structures - Increased durability by means of novel protective measures

The difficulties concerning construction projects don’t stop with national borders but affect the entire territory of North and South Tyrol likewise. Strategic structures built from concrete are equally affected by external regional influences, such as climate and resources available within this Alpine area. The lack of consideration of these regional characteristics leads to stronger damages in structures, which depends on construction and load, and consequently influences the durability of buildings significantly. However these features are not considered sufficiently within the_x000D_
National and European laws and norms. This missing inter-regional guidance causes stakeholders to use different approaches, empirical methods and solutions to solve these same and reoccurring regional problems. _x000D_
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The scope of this here presented project is to combine interregional knowhow to one common pool of knowledge and to analyze regional influences and resources. The latter will be adapted to new and nature based innovative surface protections, to extend the maintenance intervals and the whole life span of concrete structures according to the European Standards of an optimized building management system. These laboratory analysis are accompanied by long term monitoring of buildings to guaranty the practical use and the plausibility of results.
Actions for Marine Protected Areas

In the Mediterranean Sea, the intensive use of maritime space calls for integrated management to avoid cumulative impacts and user conflicts. Maritime Spatial Planning (MSP) – the harmonization of human activities in marine areas - is advocated as a powerful approach to reach these goals. However, most Mediterranean countries have not yet gone through this process. The objectives of this project are 1- to develop shared methodologies and geospatial tools for multiple stressors assessment, coordinated environmental monitoring, multi criteria analyses and stakeholders' engagements; 2- to translate these guidelines into concrete pilot actions and coordinated strategies in selected Marine Protected Areas (MPAs) to solve hot spots of conflicts affecting marine biodiversity and the services it provides. Transnational cooperation and regulations, development of coordinated best practices to deal with present and future drivers of changes in biodiversity and ecosystem services, coordinated monitoring, data access to share information and concrete stakeholder and users’ involvement are the expected results. The final aim is to scale up strategies and recommendations at transnational level adopting an ecosystem-based approach to MSP considering the goals of the Marine Strategy Framework Directive (MSFD) across MPAs. MPA managers, public institutions, and key stakeholders working within the MPAs will benefit from the results of the project.
Research model for farm building design: General structure and physiognomic characterization phase

The design of contemporary farm buildings often subordinates architectural quality and aesthetic features to economic aspects, thus leading to poor landscape consistency and compatibility. The research presented in this paper is based on the theoretical principle that historic rural buildings, being expression of an accumulation of empirical knowledge broadly associated with high architectural quality, have remarkable potentials to contribute with useful elements to the design of contemporary buildings, and on the awareness that the design process is also necessarily and substantially determined by technological, economic and functional variables. The paper presents the FarmBuiLD model (Farm Building Landscape Design), a research model proposed by the authors as a tool for the analysis of the architectural characteristics of both historical and contemporary rural buildings, as well as the meta-design of new construction and transformation of contemporary rural buildings. In particular, the work focuses on the general structure of this model and a synthesis of the main results of the critical analysis of the scientific literature aimed at identifying a set of synthetic architectural parameters suitable for its implementation, through the interpretation of the main physiognomical characteristics of rural buildings. These parameters are not meant as a tool to obtain quantitative data to be translated into design constraints automatically; on the contrary, they are mainly considered as an interpretive-analytical tool, part of a broader knowledge framework aimed at supporting, stimulating and suggesting the design choices. Keywords: Rural building design, historical-typological consistency, landscape compatibility, architectural quality, analytical and meta-design criteria, Italian rural building heritage Citation: Tassinari P, D. Torreggiani, S. Benni, and E. Dall’Ara. Research model f or farm building design: General structure and physiognomic characterization phase . Agric Eng Int: CIGR Journal, 2010; 12(1): 47 - 54 .
Agrochemıcal Indıcatıons of the Deposıts of Azerbaıjan and Effect of Erosıon Process on Plant Productıvıty

Taking all these into account, it is important to increase the fertility of the soil from the erosion process in Ismayilli and to prevent the washing of fodder crops from perennial herbs. The cultivation of these plants in the mountainous regions protects the slopes from the terrible erosion process and provides the animals with a strong fodder. It is proved by the results of the research that restoration of fertility and ecological balance of erosion lands and the implementation of soil-agro-technical measures to increase productivity are of great importance. Due to the application of these measures, I, as a result of improving the water and physical properties of the affected land, prevent surface water flows. In addition, the results of the study have been proven by the fact that, for certain reason, erosion and erosion hazards are most likely to be taken over by the sowing of perennial herbs. Thus, perennial herbs, in particular, accumulate the nitrogen atmosphere of the legumes, enriches the soil with organic matter, accelerates the formation of water-resistant granular - topical structure and improves its water-physical properties, which in turn facilitates the rapid digestion of foodstuffs
METHOD OF IMPROVING CONFORMANCE APPLICATIONS

A method of treating a reservoir penetrated by at least one well is provided. In accordance with the method, a consolidated solids pack is placed into a permeable zone of rock in the reservoir. The consolidated solids pack has a reduced permeability to water and a reduced mobility in the permeable zone. For example, when placed in the permeable zone in connection with a water flooding operation, the consolidated solids pack diverts the injectant from the permeable zone to other less permeable zones of the reservoir that contain oil.