SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Controlled cryo-em sample preparation through dna-origami pillars

Electron cryomicroscopy (cryo-EM) is rapidly emerging as a powerful technique for high-resolution structure determination of protein complexes. Despite recent advances, there is still ample room for improvement of this method, in particular regarding sample preparation. Outstanding challenges are reproducibility of freezing conditions to obtain an optimal ice thickness; to prevent unfolding or preferential orientation of proteins against the hydrophobic air-water interface; and a limited accuracy of beam-induced motion correction for relatively small particles. Here, we propose to study how DNA origami objects that are added in with the sample may affect cryo-EM grid preparation. In addition, by examining a variety of DNA origami structures in the electron microscope, we also aim to identify and improve on structural weaknesses in their design. We will test new design strategies, analyse those, and use them for application in cryo-EM. Thereby, this proposal will facilitate both cryo-EM structure determination and the design of nano-tools that are made from DNA.
Molecular diversification of inhibitory neurons during development

Cortical interneurons are a diverse class of inhibitory neurons that play a particularly important role in the stability of the neural circuits underlying cognitive and higher order brain functions. A growing body of evidence suggests that perturbation of interneuron development can result in a variety of complex neuropsychiatric disorders, including autism, bipolar disorder, and schizophrenia. Thus, elucidating how interneurons develop and integrate into canonical brain circuits is crucial for understanding the brain in both health and disease. 

During perinatal development, intrinsic and environmental processes cooperate to establish the adult form of brain connectivity and behaviour control. To elucidate the molecular mechanisms underlying these interactive processes, I propose to combine genetic fate-mapping techniques with high-throughput single-cell RNA sequencing technologies to gain a detailed understanding of neurogenesis at the cellular level and elucidate how an immense diversity of interneuron subtypes is generated (Aim 1). Furthermore, I will utilize a novel retroviral barcoding strategy to reveal how much of an interneuron’s fate is genetically predetermined by lineage within progenitor zones of the ventral forebrain (Aim 2). Finally, I will study the genetic mechanisms that enable cell intrinsic programs to be shaped by environmental activity-dependent processes during the critical window of development (Aim 3). Candidate genes resulting from these aims will be functionally characterized through gain of function and loss of function methods. 

This proposal takes full advantage of my extensive training in viral and mouse genetic techniques, single-cell transcriptomic data processing, and in vivo manipulation of neuronal activity. I am confident that I will be able to successfully complete the proposed aims while exploring fascinating and long-standing questions of developmental neurobiology.
Semiconductor-Based quantum network

Quantum networking would enable the connection of quantum processing nodes to increase computing power, long distance intrinsically secure communication, and the sharing of quantum resources over wide networks. Fully realizing these prospects requires local nodes with many coupled qubits connected by photonic links. Currently, qubits with good prospects for scaling to large numbers provide no optical interface, while optically addressable systems appear difficult to scale. This project aims to establish the fundamentals for quantum networks consisting of potentially scalable semiconductor spin qubits in gated GaAs quantum dots. These electrically controlled qubits have been proven viable for quantum computing, but so far have not been interfaced coherently with photons.
To achieve the latter, we plan to use local electric fields generated by gate electrodes on both sides of a quantum well to create bound exciton states in a semiconductor structure that also hosts quantum dot qubits. These hybrid devices will make results from semiconductor quantum optics and self-assembled quantum dots applicable to gate-defined quantum dots. Besides laying the foundations for our technological goal, such a connection of two very active subfields will open a broad range of new possibilities. 
Building on the capability to optically address our qubits, we plan to implement a protocol to transfer their quantum state to a photon. In addition, we plan to implement exchange-based two-qubit gates for two-electron spin qubits, which promise a much higher fidelity than the demonstrated Coulomb-coupled gates. Such high fidelity entangling gates are essential for quantum information processing. We then aim to integrate a photon interface into a two-qubit device in order to entangle a photonic flying qubit and a scalable semiconductor qubit. Finally, two such devices will be used to entangle separate semiconductor qubits via a photonic link, thus demonstrating a minimal network.
Forced displacement and refugee-host community solidarity

In 2015 and 2016, the EU experienced an unparalleled influx refugees and migrants. This situation poses multiple challenges for social- and health services and labour markets in host communities as well as for the lives of the refugees. 
In response to this situation, the vision of FOCUS is to increase understanding of, and provide effective and evidence-based solutions for, the challenges of forced migration within host communities and thereby contribute to increased tolerance, peaceful coexistence, and reduced radicalization across Europe and in the Middle East. 
Based on a comprehensive mapping and trans-disciplinary, multi-site field research conducted in Jordan, Croatia, Germany and Sweden, FOCUS explores the socio-psychological dimensions of refugee- and host-community relations and analyses the socio-economic integration of refugees and the consequences of this in host societies. The research sites have been selected to ensure that insights and lessons are derived from medium- and long-term experiences with forced displacement and local integration.
This knowledge is used to transform and strengthen existing promising solutions for social- and labour market integration. The integration solutions will be pilot tested in at least five European countries by governmental and non-governmental end-users. The solutions are finally brought together in the Refugee and Host Community Toolbox, which will support policy makers, municipal actors, civil society organisations and other stakeholders in responding to the needs of both refugees and host communities and thereby act as agents of change in this field.
In addition, FOCUS undertakes an ambitious programme of engagement with policy makers, end-users, host communities, refugees and other stakeholders. This will ensure that FOCUS research and solutions are acceptable and useful for policy makers, while meeting the needs of end-user organisations and ultimately refugees and host communities.
Antidepressant activated biochemical pathways and biomarker candidates

Most of the commonly used antidepressants block monoamine reuptake transporters to enhance serotonergic or noradrenergic neurotransmission. Effects besides or downstream of increased monoaminergic neurotransmission are poorly understood and yet presumably important for the drugs’ mode of action. In my PhD thesis I employed proteomics and metabolomics technologies combined with in silico analyses and identified cellular pathways affected by antidepressant drug treatment. DBA/2 mice were treated with paroxetine as a representative Selective Serotonin Reuptake Inhibitor (SSRI). Hippocampal protein levels were compared between chronic paroxetine- and vehicle-treated animals using in vivo 15N metabolic labeling combined with mass spectrometry. I also studied chronic changes in the hippocampus using unbiased metabolite profiling and the time course of metabolic changes with the help of a targeted polar metabolomics profiling platform. I identified profound alterations related to hippocampal energy metabolism. Glycolytic metabolite levels acutely increased while Krebs cycle metabolite levels decreased upon chronic treatment. Changes in energy metabolism were influenced by altered glycogen metabolism rather than by altered glycolytic or Krebs cycle enzyme levels. Increased energy levels were reflected by an increased ATP/ADP ratio and by increased ratios of high-to-low energy purines and pyrimidines. Paralleling the shift towards aerobic glycolysis upon paroxetine treatment I identified decreased levels of Krebs cycle and oxidative phosphorylation enzyme levels upon the antidepressant-like 15N isotope effect in high-anxiety behavior mice. In the course of my analyses I also identified GABA, galactose-6-phosphate and leucine as biomarker candidates for the assessment of chronic paroxetine treatment effects in the periphery and myo-inositol as biomarker candidate for an early assessment of chronic treatment effects. The identified antidepressant drug treatment affected molecular pathways and novel SSRI modes of action warrant consideration in antidepressant drug development efforts.
A COMPACT OPTICAL FINGERPRINT CAPTURING AND RECOGNITION SYSTEM

An apparatus and method for acquiring an image of a patterned object such as a fingerprint including a light refracting device, a focusing lens, a light source, and a biometric circuit for detecting the presence of a patterned object such as a fingerprint at the light refracting device. Incident light from the light source is projected through a light receiving surface of the light refracting device and is directly reflected off an imaging surface. The resulting image is projected through the focusing lens. The focusing lens has a diameter which is larger than the projection of the patterned object through the light refracting device.
Effects of Color, Pattern, and Sound on the Movement of Houseflies

As diseases spread by flies have continuously increased in frequency since the 1970s, methods to control the flies’ motion have been studied. In this paper, a novel method is proposed by examining the impact of diverse sensory stimuli on houseflies’ motion. Among various patterns and colors, red striped pattern was the best as fly repellent, and the pattern of white circles on a blue background the best attraction. For sound, a frequency of 10 kHz and 20 kHz had repelling power. When examined for its relationship with the alluring smell of food, red stripes repelled more than 26.3% of flies from the smell. Under the same conditions, 10 kHz and 20 kHz each showed repelling power over about 19% in the presence of an olfactory luring factor. Therefore, the pattern of red stripes and the auditory stimuli of 10 kHz or 20 kHz should be incorporated into various aspects of our lives, along with the living environment of disease-stricken areas.
3D and digital shipbuilding

Project to develop the capacity to exploit the potential of digital in a company with very strong sector-specific basic technologies and skills
Ustekinumab as an Alternative Treatment Option for Chronic Pityriasis Rubra Pilaris

Pityriasis rubra pilaris (PRP) is an exceptionally rare, chronic inflammatory dermatosis of unknown etiology. Patients classically present with small, follicular keratosis and salmon-colored plaques that begin at the head and neck and slowly progress to widespread erythroderma including the palms and soles. It is difficult to distinguish PRP from other inflammatory dermatoses; however, features that help aid in the diagnosis include 'islands' of spared skin, orangish hue and typical findings on biopsy. There are no specific guidelines on therapy and treatment options include corticosteroids, vitamin D analogs, retinoids, methotrexate, cyclosporine, azathioprine and tumor necrosis factor alpha antagonists. Unfortunately options are limited for patients when these drugs do not work. We report a case of chronic PRP, refractory to conventional treatment, successfully treated with ustekinumab monotherapy. The patient was treated with 90 mg subcutaneous ustekinumab injections and began to show improvement within only 8 weeks. Long-term control of the disease has been attained without any significant side effects. We report this case to show that ustekinumab can be used as an alternative treatment method for patients with chronic, unremitting PRP. Treatment response is remarkably rapid and the infrequent dosing leads to patient compliance and a significantly improved quality of life.
SYSTEM AND METHOD FOR MODELING AND VERIFYING FINANCIAL TRADING PLATFORMS

A computer-implemented method assesses operation of a financial computing system (FCS). An assessment computer system generates code for a model of the FCS that comprises a model specification for the FCS and a model environment for the FCS. The code for the model uses a type-system based logical programming language that supports typed recursive functions. The assessment computer system generates mathematical axioms that describe the operation of the FCS by compiling the code for the model and assesses the operation of the financial computer system by analyzing the mathematical axioms.
Adaptive Bayesian Approach to Clinical Trial Renal Impairment Biomarker Signal from Urea and Creatinine

A major concern with the identification of renal toxicity using the traditional biomarkers, urea and creatinine, is that toxicity signal definitions are not sensitive to medically important changes in these biomarkers. Traditional renal signal definitions for urea and creatinine have not adequately identified drugs that have generated important medical issues later in development. Here, two clinical trial databases with a posteriori known drug induced renal impairment were analyzed for the presence of a renal impairment biomarker signal from urea (590 patients; age 26-92, median 65) and creatinine (532 patients; age 26-97, median 65). Data was analyzed retrospectively using multiple definitions for the biomarker signal to include values outside stratified reference intervals, values exceeding twofold increases from baseline, values classified by the 2009 NIAID renal toxicity table, change from baseline represented as a Z-score based on intra-individual biological variations, and an adaptive Bayesian methodology that generalizes population- with individual-based methods for evaluating a biomarker signal. The data demonstrated that the adaptive Bayesian methodology generated a prominent drug induced signal for renal impairment at the first visit after drug administration. The signal was directly related to dose and time of drug administration. All other data analysis methods produced none or significantly weaker signals than the adaptive Bayesian approach. Interestingly, serum creatinine and urea are able to detect early kidney dysfunction when the biomarker signal is personalized.
Globalisation, europe and multilateralism - sophistication of the transnational order, networks and european strategies

This is a European Joint Doctorat (EJD) gathering 16 partner organizations from 3 different continents. It includes 5 EU HEIs, 3 non-EU HEIs, 3 Think Tanks, 2 MNEs, 1 SME, 1 NPO & 1 EU Intitution.
It's shared research agenda on ""Globalisation, Europe and Multilateralism"" seeks to unpack the growing ""Sophistication of the Transnational Order, Networks and European Strategies"" in light of the EU's attempts at regime complex management. To this effect, the EU's response to international institutional proliferation is alternatively analyzed through the lens of its ability to provide purposeful complex regime management in light of its institutional capacities, network capacities, relative capacities and framing capacities. 
Collectively GEM-STONES will increase the breath of regime complex management theory as its postulates are confronted with the specific experience of the EU. The project will also  expand the state-of-the art in EU studies, notably on the EU's external action. The research will ultimately sketch a nuanced, innovative, and interdisciplinary answer to the question: how does the EU contributes towards the management of institutional proliferation?
To meet this research objective, while also strengthening the EU's innovation capacities, GEM-STONES will select and train 15 highly competitive ESRs. Its chosen interdisciplinary research and training methods bridg a variety of SSH disciplines. Each ESR will accomplish a specific research project as part of the overall agenda. Ultimately, if successful, ESRs will be awarded a Double Degree from two of the project's HEIs.
Training is to be an integrated curriculum designed to foster structured PhD training at the EU level, and allow for novel public-private collaborations. The 180 ECTS worth of training will be provided through research, education & practice and will incl. a significant internship.
Joseph Priestly (1733–1804)

Publisher Summary Joseph Priestley (1733–1804) was a notable theologian, philosopher and chemist of the Enlightenment era. He was a prominent figure in the dissenting circles of provincial England, spending significant phases of his life in Leeds and Birmingham. He entered science with a historical project on electricity, and gained international fame with his work on pneumatic chemistry. He discovered and studied many new gases including what he called dephlogisticated air, later dubbed oxygen by Lavoisier. Priestley's work on pneumatic chemistry was strongly driven by his concern about the goodness of air, and he used the phlogiston theory to help him make sense of a great variety of phenomena that he observed. Today he is often remembered as a dogmatic defender of the phlogiston theory, but on the contrary he was committed to a pluralistic and empiricist scientific method, and attacked Lavoisier's school for their dogmatism. Priestley was driven out of England for his support of the French Revolution, and died in exile in rural Pennsylvania.
Efficient production and synchronization of linked content for two-screen systems

This paper proposes a two-screen system configured from a TV set as the first screen and a tablet computer as the second screen. Text data sent as caption text from the TV is used to automatically create computer graphic (CG) video on the tablet computer. By employing TV program Making Language (TVML) to create the CG video from textual content, a highly efficient system has been developed for producing expressive content using minimal caption channel bandwidth. A prototype two-screen system is described that generates related video content with relatively little effort, provides a simple synchronization scheme, and supports real-time interworking between the two screens.
Quality Ageing in an Urban Environment

Almost all cities and regions in Europe face radical changes in the structure of society at the moment. Due to demographic change the number of older workers (55-64), elderly people (65-79), and very elderly people (80+) increases while the number of people in working age decreases. Accelerated demographic ageing can seriously threaten the achievement of the Lisbon agenda’s main objective to increase the competitiveness of Europe by mobilizing all existing development potentials. Increased competitiveness of Central Europe hence depends on the success of creating a competitive international investment climate, where the elderly are a well-integrated layer of society.

Q-AGEING is focused on creating better conditions to enable active ageing by developing actions which really belong to the competences and legal responsibilities of local/regional authorities. Therefore the actions are concentrated on public services and urban living environment. Both aspects are interlinked.

A balanced society in which seniors play an active role, where public services for the older generation are well organised and which has an urban structure adapted to the specific needs of an ageing population is an important quality aspect which plays also a role in investment decisions for international firms. Active ageing is therefore a main concern and still primarily linked to job creation, which contributes to social well-being. To achieve this it is necessary to enhance social acceptance of seniors by both employers and the wider society and to prepare the senior workforce to become more competent and competitive through lifelong learning.

To reach the objectives of the project it is up to the public sector partners in the project, together with knowledge institutes and an expert panel to create the conditions facilitating this process by putting innovative state of the art solutions for service provision into practice, by adapting cities and the urban environment to the specific needs of elderly people and by using and/or promoting new technologies to bring innovative and effective solutions to public services.
Method and apparatus for handling web

For use in a web-handling apparatus, a cylinder module accumulates and de-accumulates web in a controlled manner. A frame supports first (23) and second (26) parallel main cylinders. The first cylinder (23) rotates continuously, while the second cylinder (26) operates in a non-uniform manner. A third main cylinder (25) remains parallel with the first and second axes while moving perpendicular to those axes. The web passes around the first cylinder (23) through the first nip, thence to and around the periphery of the third cylinder (25), thence to and partially around the periphery of the second cylinder (24) and through the second nip. The web spans from the third cylinder (25) are substantially parallel. An endless belt associated with each end of the third cylinder ensures that the third cylinder occupies an axis location and a rotational position which substantially control the web stress as the web (7) passes through the cylinders (23,25,26).
GAmifIcation for Memorable tourist experienceS

Today’s demanding and discerning tourists don’t want just to observe, they wish to experience places. This experiential tourism trend is relevant to off-season travellers who choose this time of the year not only to lower costs but also to avoid crowds and increase chances for authentic interactions with locals. That's why MED GAIMS project will develop games in physical and virtual format to create experiences for tourists, giving a necessary competitive edge to the attractiveness of less-known sites. The project seeks to increase tourism flows, covering all niches and segments like off-season travellers, creating jobs opportunities and start-ups for game entrepreneurs. Gamification is culturally sensitive – we do not all have the same sense of what is fun – so multicultural, cross-border evaluation of the initiatives will be performed by the project before opening them up to international tourists. Eventually, 40 games will be selected and implemented in 12 tourism sites from 8 destinations.
Imitation in heterogeneous populations

We study a boundedly rational model of imitation when payoff distributions of actions differ across types of individuals. Individuals observe others’ actions and payoffs, and a comparison signal. One of two inefficiencies always arises: (i) uniform adoption, i.e., all individuals choose the action that is optimal for one type but suboptimal for the other, or (ii) dual incomplete learning, i.e., only a fraction of each type chooses its optimal action. Which one occurs depends on the composition of the populations and how critical the choice is for different types of individuals. In an application, we show that a monopolist serving a populations of boundedly rational consumers cannot fully extract the surplus of high-valuation consumers, but can sell to consumers who do not value the good.