SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Cruise and passenger ship Air quality Impact Mitigation ActioNs

CAIMANs studies the impact of passenger maritime traffic on air quality in five important port cities in the northen Mediterranean: Barcelona, Marseilles, Genoa, Venice and Thessaloniki. It expands its analysis on the whole Mediterranean area, trough a participatory consulation towards other port cities, including southern Mediterranean coasts.
CAIMANs aim to pave the way for a joint policy response on the air pollution impact due to the tourist sector of cruise and passenger ship in the Mediterranean basin in order to reach an integrated approch concerning the mitigation of environmental risks (Integrated Maritime Policy for the Mediterranean)
Oscillibacter ruminantium sp. nov., isolated from the rumen of Korean native cattle

A strictly anaerobic, Gram-negative, non-spore-forming bacterium, designated GH1 T , was isolated from the rumen of Korean native cattle (HanWoo). Cells were straight to slightly curved rods (2.0–4.5 µm long) and were motile by peritrichous flagella. The isolate grew at 30–45 °C (optimum 40 °C), at pH 5.5–6.5 (optimum pH 6.0) and with up to 3.5 % (w/v) NaCl. Strain GH1 T produced acid from d -glucose, d -ribose and d -xylose, with butyric acid being the major end product. The genomic DNA G+C content was 54.6 mol%. Based on comparative 16S rRNA gene sequence analysis, strain GH1 T was most closely related to Oscillibacter valericigenes Sjm18-20 T (97.3 % 16S rRNA gene sequence similarity). DNA–DNA hybridization between strain GH1 T and O. valericigenes DSM 18026 T showed 24 % reassociation. The major fatty acids were iso-C 13 : 0 (13.0 %), iso-C 15 : 0 (17.6 %), anteiso-C 15 : 0 (8.4 %) and C 14 : 0 (4.1 %), and the cellular fatty acid methyl esters as dimethylacetals (DMAs) were C 16 : 0 DMA (17.8 %), iso-C 15 : 0 DMA (15.2 %) and C 14 : 0 DMA (4.52 %). The cell-wall peptidoglycan of strain GH1 T contained meso -diaminopimelic acid and the major cell-wall sugar was galactose. Based on 16S rRNA gene sequence similarity, phylogenetic analysis, DNA G+C content, DNA–DNA relatedness and distinct phenotypic characteristics, strain GH1 T is classified in the genus Oscillibacter as a member of a novel species, for which the name Oscillibacter ruminantium sp. nov. is proposed. The type strain is GH1 T ( = KCTC 15176 T = NBRC 108824 T = JCM 18333 T ).
Microbiome applications for sustainable food systems through technologies and enterprise

Although microorganisms dominate almost every ecological niche in our planet, it has only been during the past 10-15 years that we have begun to gain insights into the composition and function of microbial communities (microbiomes) as a consequence of major advances in High Throughput DNA sequencing (HTS) technologies. These approaches have allowed a comprehensive analysis of microbiomes for the first time. Following initial curiosity-driven investigations of microbiomes using HTS technologies, the field has evolved to harness the insights provided, leading to the development of a new multi-billion euro industry focused on characterisation and modulation of microbiomes. The vast majority of this investment has been in the clinical space. In contrast, far less is known about microbiomes across complex food chains, making it difficult to harness food-chain microbiome data for the development of more sustainable food systems and to yield innovative products and applications. This is despite the evident importance of microbes throughout the food chain. MASTER will take a global approach to the development of concrete microbiome products, foods/feeds, services  or processes with high commercial potential, which will benefit society through improving the quantity, quality and safety of food, across multiple food chains, to include marine, plant, soil, rumen, meat, brewing, vegetable waste, and fermented foods. This will be achieved through mining microbiome data relating to the food chain, developing big data management tools to identify inter-relations between microbiomes across food chains, and generating applications which promote sustainability, circularity and contribute to waste management and climate change mitigation. We will harness microbiome knowledge to significantly enhance the health and resilience of fish, plants, soil, animals and humans, improve professional skills and competencies, and support the creation of new jobs in the food sector and bioeconomy.
Exploiting Potentials of Social Enterprises through Standardized European Evaluation and Development System

In 2011, the European Commission launched the Social Business Initiative (SBI)2 in a recognition of the growing social economy & entrepreneurship that accounts for more than 11 millions of workers, 4.5 % of the active EU population. Since then, a lot has been achieved (e.g. the European Social Entrepreneurship Fund, Social Stock Exchanges), however, policies addressed to social enterprises are still under-developed and fragmented in most Member States. Motivated by the above challenge, SOCIAL SEEDS partnership aims to equip policy-makers with evidence-based policy diagnostic tool that increases the effectiveness of local and regional policies for stimulation of growth & employment (preferably of vulnerable social groups) in social enterprises (SE) including their eco-systems in European cities and regions. To this end, regional and local government-run measurement and labelling scheme addressed to social enterprises (SE) will be established. It will help policy-makers’ concrete actions towards creating the right conditions to allow the sector to thrive. This new scheme will be fully exploitable - regardless of sectors, size of enterprises, maturity - and aligned throughout three different policy-making spheres enabling consensus between bottom-up and top-down implications. Although, similar issues related to strengthening the position of SEs within the private & public sphere has already been part of EU development agendas for many years, but the focus on ranking and benchmarking regional and local SEs according to policy metrics is new. Therefore, SOCIAL SEEDS partners believe that the achievements will efficiently contribute to shaping European policymaking as well as engage multi-stakeholders in the way policies are generated, implemented and monitored.
Revolutionary secure payment management system to integrate the different elements of the payment industry with the use of sepa

Until now, the payment market has been strongly segmented with many incompatible payment solutions. Market investments are introducing many new payment methods but the underlying architecture remains the same and is only getting more complicated.
Since 2010, PayPlaza has been developing a revolutionary secure payment management system to integrate the different elements of the payment industry. Payplaza is seeking to develop this platform to handle any payment transaction from any platform (e-commerce / terminal / POS) in any country and with any currency.
By providing an interface which separates the different layers of data, PayPlaza enables the integration of different payment elements in a matter of days. Thanks to the integration layer, users have freedom of choosing Point-of-Sale software, payment terminals and acquirers across the globe, whilst applying the highest security principles. 
This is the much needed solution for international organisations with operations in several countries, dealing with different payment service providers, payment terminals, ECR (software) integrations, various acquirers and bank contracts. Their cost savings include a reduction in maintenance and administration costs thanks to dealing with only the PayPlaza platform. As well as lower transaction costs thanks to being able to operate with any of the payment solution providers. Additionally, Payplaza is building dashboard functionality which will allow the users to make sense of all their data, hereby supporting their future growth. 
Further more users gain more functionalities such as processing biometrics, alternative payments, loyalty or any other transaction.
PayPlaza has built the minimal viable product to solve these problems and now seeks to seize the market opportunity, which will be done by performing a feasibility study in phase 1, followed by a phase 2 project where PayPlaza will build out their prototype to a fully certified, scalable and redundant platform.
Air: Greenhouse Gases from Agriculture

Agriculture makes a major contribution to the emission of greenhouse gases. The gases are nitrous oxide, methane, and carbon dioxide. Nitrous oxide emissions are released primarily as a result of the application of nitrogen-based fertilizers and manures. Agricultural methane emissions are derived mostly from ruminant livestock and rice production, and carbon dioxide emissions are associated mainly with emerging changes in land use. In the coming decades, there will be pressure on global agricultural systems to increase the production of food to feed the world’s growing population; however, technologies are available to help achieve this in ways that also contribute to greenhouse gas mitigation from agricultural systems.
Secur Med Plus

SECUR MED PLUS is the new project focused on maritime safety and environmental protection that the Liguria Region wants to launch in the new European programme MED . The project promotes common strategic actions aimed at strengthening safety of the maritime cluster in the Mediterranean. The new project proposal is based on the implementation, development and prosecutions of positive experiences of other cooperation projects (SECURMED, just ended; and AEM MED. SECUR MED PLUS has the ambitious goal of strengthening the alliance between regional governments, ministries, Port Authorities and Research Centres initiated during previous projects in order to capitalize already obtained results. This goal will be obtained through: the development of the priority themes determined by the Centres Network created during the previous period (ReCRIS), the development of innovative systems able to increase the operational capacity of the Network (database, ICT for the integration of control navigation systems, common indicators for verifying environmental and social compatibility of harbour activities); the development of common policies and strategies, which according international, national and local legislation, are able to increase the decision making and operational capacity in the field of maritime and harbour safety
METHODS FOR SCREENING MONOCLONAL ANTIBODIES ON HETEROGENEOUS ANTIGEN SUBSTRATES

Methods, compounds, and polyclonal antibody libraries (PALs) that relate to screeing and selection of antibodies and the cells that produce them are disclosed. In particular, an antigen or a subset of antigens which has some desired feature can be distinguished from a multitude of other undesired antigens present in a heterogeneous antigen mixture which lack such feature by use of PALs raised against the undesired antigens. When such PALs are brought into contact with a heterogeneous antigen substrate, the antibodies in the PAL can bind to those antigens, masking them from subsequenty binding by a test antibody having a similar specificity. By decreasing binding of test antibodies to those undesired antigens, if binding of test antibodies to the substrate occurs, such binding will more likely be by way of binding of the antibody to a desired antigen in the mixed antigen substrate. Thus, this invention can improve the efficiency of screening antibodies directed towards desired antigens. By appropriate selection of a PAL, effects such as false positives can be decreased, even for unknown undesirable antigens.
JERSEY HANGER ASSEMBLY AND JERSEY DISPLAY

A jersey hanger assembly is described. The jersey hanger assembly allows homes, businesses, schools, or other buildings to display an athletic jersey as a symbol of team pride or of support for an athletic team or an individual player on the team. The jersey hanger assembly includes a bracket member. The bracket member includes a receiving member. The jersey hanger assembly includes a pole with first and second opposing ends. The second pole end is insertable into the receiving member. The pole has a curved shape between the first and second opposing ends. A jersey flag for hanging on the jersey hanger is described. The jersey flag is material of a fabric cut or shaped to resemble an athletic jersey. The material includes a team logo or insignia. A sleeve or an open seam in positioned in the upper portion of the jersey flag to receive the pole.
Étudier les dynamiques de peuplement entre l'Èbre moyen et les Pyrénées occidentales durant l’Antiquité tardive (III – VIIe siècle) avec les SIG. Première approche.

Cet article propose une analyse du peuplement rural tardoantique (IIIe -VIIe siècles) dans l’espace situé entre l’Èbre et la chaîne des Pyrénées, une aire d’étude qui n’a pas bénéficié jusqu’à présent de synthèse archéologique sur le peuplement à cette période. En traitant les données avec un SIG, l’article vise à cerner les dynamiques spatiales et temporelles du peuplement rural durant l’Antiquité tardive. Le corpus d’étude est composé de données obtenues grâce aux rapports de fouille, d’archéologie préventive et programmée, et aux prospections, afin d’établir une première approche du peuplement en prenant en considération tous les renseignements disponibles. Nous allons corréler différentes variables spatiales et temporelles : l’intensité du travail archéologique, le potentiel agricole, l’espacement entre les sites, l’altitude, la distance par rapport aux voies de communication (fluviales et viaires), l’évolution de la représentation de sites dans le système de peuplement. La dynamique des sites est aussi étudiée en prenant en compte leur fonction (villae, fermes, nécropoles, etc.). Les résultats de ces études statistiques fournissent une première approche des dynamiques de la zone étudiée. Ainsi, on constate un tournant qui s’opère au Ve siècle : nous observons un changement significatif dans la dynamique du peuplement ainsi qu’une réduction drastique des sites ruraux actifs. Cela permet de bien distinguer deux modèles de peuplement : Le premier, un modèle compris entre le IIIe siècle et la première moitié du Ve siècle et, le second, pour la période comprise entre la fin du Ve siècle et le VIIe siècle. Mots-clés Peuplement, Pyrénées, dynamiques spatio-temporelles, analyses spatiales, Antiquité tardive.
The Provision of Interventional Radiology Services in Europe: CIRSE Recommendations

Interventional Radiology (IR) is an essential part of modern medicine, delivering minimally invasive patient-focused care, which has been proven to be safe and effective in both elective and emergency settings. The aim of this document is to outline the core requirements and standards for the provision of Interventional Radiological services, including training, certification, manpower, and accreditation. The ultimate challenge will be the adoption of these recommendations by different countries and health economies around the world, in turn ensuring equal access to IR treatments for all patients, the appropriate distribution of resources for IR service provision as well as the continued development of safe and high-quality IR services in Europe and beyond.
Randomized Trial of Closed-Loop Control in Very Young Children with Type 1 Diabetes

The possible advantage of hybrid closed-loop therapy (i.e., artificial pancreas) over sensor-augmented pump therapy in very young children with type 1 diabetes is unclear.In this multicenter, randomized, crossover trial, we recruited children 1 to 7 years of age with type 1 diabetes who were receiving insulin-pump therapy at seven centers across Austria, Germany, Luxembourg, and the United Kingdom. Participants received treatment in two 16-week periods, in random order, in which the closed-loop system was compared with sensor-augmented pump therapy (control). The primary end point was the between-treatment difference in the percentage of time that the sensor glucose measurement was in the target range (70 to 180 mg per deciliter) during each 16-week period. The analysis was conducted according to the intention-to-treat principle. Key secondary end points included the percentage of time spent in a hyperglycemic state (glucose level, >180 mg per deciliter), the glycated hemoglobin level, the mean sensor glucose level, and the percentage of time spent in a hypoglycemic state (glucose level, <70 mg per deciliter). Safety was assessed.A total of 74 participants underwent randomization. The mean (±SD) age of the participants was 5.6±1.6 years, and the baseline glycated hemoglobin level was 7.3±0.7%. The percentage of time with the glucose level in the target range was 8.7 percentage points (95% confidence interval [CI], 7.4 to 9.9) higher during the closed-loop period than during the control period (P<0.001). The mean adjusted difference (closed-loop minus control) in the percentage of time spent in a hyperglycemic state was -8.5 percentage points (95% CI, -9.9 to -7.1), the difference in the glycated hemoglobin level was -0.4 percentage points (95% CI, -0.5 to -0.3), and the difference in the mean sensor glucose level was -12.3 mg per deciliter (95% CI, -14.8 to -9.8) (P<0.001 for all comparisons). The time spent in a hypoglycemic state was similar with the two treatments (P = 0.74). The median time spent in the closed-loop mode was 95% (interquartile range, 92 to 97) over the 16-week closed-loop period. One serious adverse event of severe hypoglycemia occurred during the closed-loop period. One serious adverse event that was deemed to be unrelated to treatment occurred.A hybrid closed-loop system significantly improved glycemic control in very young children with type 1 diabetes, without increasing the time spent in hypoglycemia. (Funded by the European Commission and others; ClinicalTrials.gov number, NCT03784027.).
Cognitive tomography of mental representations

Internal models are fundamental to our understanding of how the mind constructs percepts, makes decisions, controls movements, and interacts with others. Yet, we lack principled quantitative methods to systematically estimate internal models from observable behaviour, and current approaches for discovering their mental representations remain heuristic and piecemeal. I propose to develop a set of novel 'doubly Bayesian' data analytical methods, using state-of-the-art Bayesian statistical and machine learning techniques to infer humans' internal models formalised as prior distributions in Bayesian models of cognition. This approach, cognitive tomography, takes a series of behavioural observations, each of which in itself may have very limited information content, and accumulates a detailed reconstruction of the internal model based on these observations. I also propose a set of stringent, quantifiable criteria which will be systematically applied at each step of the proposed work to rigorously assess the success of our approach. These methodological advances will allow us to track how the structured, task-general internal models that are so fundamental to humans' superior cognitive abilities, change over time as a result of decay, interference, and learning. We will apply cognitive tomography to a variety of experimental data sets, collected by our collaborators, in paradigms ranging from perceptual learning, through visual and motor structure learning, to social and concept learning. These analyses will allow us to conclusively and quantitatively test our central hypothesis that, rather than simply changing along a single 'memory strength' dimension, internal models typically change via complex and consistent patterns of transformations along multiple dimensions simultaneously. To facilitate the widespread use of our methods, we will release and support off-the-shelf usable implementations of our algorithms together with synthetic and real test data sets.
Keynes, family allowances, and Keynesian economic policy

This paper provides a short history of family allowances and documents the fact that Keynes supported family allowances as early as the 1920s, continuing through the 1930s and early 1940s. Keynes saw this policy as a way to help households raise their children and also as a way to increase consumption without reducing business investment. The paper goes on to argue that a policy of family allowances is consistent with Keynesian economics. Finally, the paper uses the Luxembourg Income Study to estimate the impact of family allowances on child poverty in several developed nations and estimates the poverty-reducing impact of several possible family allowance programs for the US.
Targeting human kallikreins involved in ovarian cancer pathogenesis: novel activity based probes and kallikrein-based therapeutic strategies.

Ovarian cancer (OvCa) is one of the most fatal female gynaecological malignancies, resulting in 180,000 deaths annually. The majority of patients have metastatic disease at time of diagnosis, thus, early diagnosis of OvCa remains a challenge to our society. In addition, the low survival rates over the past decades have remained largely unchanged, evidencing the need of new therapies for OvCa. Kallikrein-related peptidases (KLKs) are a family of 14 serine proteases which form a cross activation network known as the KLK activome. KLKs show diverse tissue expression and physiological function, and aberrant KLK expression and activity has been related to several pathological conditions including skin diseases, neurodegenerative disorders and cancer. In OvCa, KLKs4,5,6 & 7 levels are upregulated and associated with its unfavourable prognosis, therefore, KLKs4,5,6 & 7 are considered potential drug targets and biomarkers for OvCa. However, KLK activity is decoupled from simple abundance, and the contribution of each KLK activity in OvCa progression remain poorly understood. In this project, I will develop selective (quenched)-Activity Based Probes ((q)-ABPs) for KLKs4,5,6 & 7 and quantify the active enzyme fraction of each KLK to determine their contribution to OvCa. Additionally, I will develop proteolysis targeting chimeras (PROTACs) which can be selectively activated by specific KLKs to unlock their potential as therapeutic targets for OvCa. This proposal aims to deliver a versatile platform to interrogate the application of KLKs4,5,6 & 7 as biomarkers and therapeutic targets for OvCa, with potential application to other KLK- and serine protease-related disorders. My participation in this proposal will allow to bring key knowledge to face the challenging objectives and receive high-quality training that will provide me with a solid and diversified groundwork to become and independent researcher in the drug discovery field.
Produção de equipamentos de proteção para combate da COVID-19

O presente projeto visa a produção de dois tipos de equipamentos de proteção, nomeadamente óculos e viseiras, em conformidade com a norma 2001/95/CE, de froma a contribuir para o cambate à COVID-19.