SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
P127 Improving smoking cessation advice through the implementation of a quality improvement intervention

Background Smoking remains the main cause of preventable morbidity and premature death in England (DH data) and is estimated to cost the NHS £1.5 billion a year. Smoking counselling beginning during hospitalisation and including support after discharge increases smoking cessation rates (Rigotti et al 2008).1 Health professionals in the hospital are expected to offer cessation advice. An audit was carried out in the acute medical unit of 118 consecutive medical patients which demonstrated that only 1/25 current smokers received any cessation advice. In July 2010, driven by a quality improvement project carried out locally in patients admitted with community-acquired pneumonia, key indicators of high quality care were established, one of which was to clearly document and offer smoking cessation advice to current or recently-quit smokers. Despite being a requirement, documentation regarding smoking cessation advice was poor. In the respiratory wards, only seven patients were referred to existing smoking cessation services over 6 months. Several interventions were planned to increase awareness. No additional resource was required and members of the multidisciplinary team were employed in a variety of roles. An educational programme was established, including presentations to key specialities (acute and respiratory medicine) and key ward nursing staff. An in-reach programme was developed by the smoking cessation lead nurse, targeting wards where high rates of smoking were identified. Several foundation trainees were employed as “smoking champions,” raising awareness among their peers. Results Since initiation of the interventions, documented cessation advice has steadily risen from 0% to 68% of patients with a smoking history (see Abstract P127 figure 1). On the respiratory wards, 77 patients over 6 months (cf seven prior to intervention) were referred to the service. Four-week cessation rates in the patients referred to the cessation service was 82% and of these patients 70% had still ceased to smoke at 6 months. Conclusions Low cost, easily-deliverable interventions can act as important drivers to improve awareness and delivery of smoking cessation advice. We have demonstrated that simple strategies can be highly cost effective, of particular importance in this financial climate.
Heat transfer enhancement and pressure drop performance for R417A flow boiling in internally grooved tubes

The experimental study on heat transfer and pressure drop for R417A flow boiling in horizontal smooth and internally grooved tubes was conducted. Based on the experimental results, heat transfer and pressure drop performance for R417A in different tubes were compared, and the influences of vapor quality and mass flux on heat transfer enhancement and pressure drop performance were analyzed and discussed. The result indicates: enhancement factors of R417A in Tube II and Tube III focus on a range of 1.26–2.0 and 1.5–2.8 respectively, and enhancement factors vary with vapor qualities and mass fluxes. The total pressure drops for R417A in Tube II and Tube III are 1.8–2.6 times and 1.67–2.3 times of R417A in smooth tube respectively. Both enhancement factor and penalty factor increase with increasing mass flux, while enhancement parameters show different situations in different internally grooved tubes. Compared with Tube II, Tube III possesses a better heat transfer enhancement efficiency.
Innovation policy-mix learning for advanced manufacturing in European regions

Evaluation of innovation policy-mixes goes beyond traditional monitoring and innovation systems as it involves evaluating instruments interactions and overlaps from an integrated view. This is a challenge for regions and especially with regards the implementation of their Research and innovation strategies for smart specialisation (RIS3), as an innovation policy-mix has to be designed and implemented oriented towards a thematic priority.

4 Regions with Advanced Manufacturing (AM) identified within their RIS3 strategy; The Basque Country, Lithuania, Piedmont and Wales have joint the MANUMIX consortium to learn best practices through the exchange of experience in the evaluation and monitoring of their current innovation policy-mixes, a common challenge in the implementation process of RIS3 priorities.
The Interregional learning approach of the first phase of the project will have as the main result an ad-hoc action plan for each region to implement. During the second phase of the project, each partner will monitor the implementation process in the region. The Consortium will have the expert support of ORKESTRA (Advisory Partner), an institution expert on the study of competitiveness and regional development, that will support all the partners through the learning process, providing advice on the definition of their action plan and further implementation.

Thus, the general objective of MANUMIX is to strengthen and improve the effectiveness and efficiency of innovation policy-mixes for AM at regional level through evaluation. This involves evaluating interactions of regional AM instruments, trying therefore to assess both the complementarities and the overlaps among them.

Improving and strengthening the current evaluation systems, partners and later other EU regions will enhance the implementation of regional development policies and programmes that support the delivery of innovation in the AM smart specialisation area.
Concise Reviews: A Stem Cell Apostasy: A Tale of Four H Words

Abstract The field of hematopoietic stem cell (HSC) biology has become increasingly dominated by the pursuit and study of highly purified populations of HSCs. Such HSCs are typically isolated based on their cell surface marker expression patterns and ultimately defined by their multipotency and capacity for self-generation. However, even with progressively more stringent stem cell separation techniques, the resultant HSC population remains heterogeneous with respect to both self-renewal and differentiation capacity. Critical studies on unseparated whole bone marrow have definitively shown that long-term engraftable HSCs are in active cell cycle and thus continually changing phenotype. Therefore, they cannot be purified by current approaches dependent on stable surface epitope expression because the surface markers are continually changing as well. These critical cycling cells are discarded with current stem cell purifications. Despite this, research defining such characteristics as self-renewal capacity, lineage-commitment, bone marrow niches, and proliferative state of HSCs continues to focus predominantly on this small subpopulation of purified marrow cells. This review discusses the research leading to the hierarchical model of hematopoiesis and questions the dogmas pertaining to HSC quiescence and purification. Stem Cells 2015;33:15–20
Flexible mechanism

Disclosed is a flexible mechanism including: a backbone extending in a lengthwise direction thereof; a first steering wire group including one or more steering wires disposed in a spiral direction of a first direction along the lengthwise direction of the backbone and configured to transfer a handling force applied to ends thereof to an end effector; and a second steering wire group including one or more steering wires disposed in a spiral direction of a second direction, which is different from the first direction, along the lengthwise direction of the backbone and configured to transfer a handling force applied to ends thereof to the end effector.
Depressed Brainstem Auditory Function in Children With Cerebral Palsy

Brainstem auditory evoked responses were studied to examine brainstem auditory function in 80 children with cerebral palsy. The response waveform, particularly later waves, tended to be depressed. Thirty-three (41.3%) showed abnormal results. The main abnormality was reduced wave V amplitude. Other abnormalities were decreased V/I amplitude ratio, missing waves, prolonged I-V interval, and increased interaural difference in I-V interval. The abnormalities were persistent during the follow-up. In contrast to common findings in the responses in progressive neurologies, abnormalities in interpeak intervals were rare in children with cerebral palsy. There were some characteristic changes in the responses in certain etiologies. These results suggest that brainstem auditory function in children with cerebral palsy is depressed, which may be owing to decreased or altered neural firing or synchrony in the auditory brainstem. A detailed analysis of central components of the responses is valuable in detecting central auditory dysfunction in children with cerebral palsy.
A Lean Approach to Enable Sustainability in the Built Environment through BIM

Rating systems are assumed as instruments to endorse architectural quality, reliability, energy efficiency, economic convenience and finally expose a sustainability label. Moreover, these tools can be tied to a BIM model. The aim of this research is to set up a lean methodology to fulfil CESBA requirements through Construction to Operations Building information exchange – COBie in project on existing buildings adopting the BIM Bronze approach by UK Ministry of Justice - MoJ. This will allow to develop a semantic model and to extract sustainability reports in a post-construction phase, thereby minimising the cost of gathering information on existing buildings. An illustrated example regarding energy criteria of CESBA protocol will be presented to further the proposed approach.
The Long-Run Drivers of Stock Returns: Total Payouts and the Real Economy

We provide theoretical and empirical evidence over 1871–2014 that total payouts (dividends plus buybacks) are the key drivers of long-run stock market returns. We show that total payouts per share (adjusted for the share decrease from buybacks) grew in line with economic productivity, whereas aggregate total payouts grew in line with GDP. We also show that a dividend discount model (DDM) based on current yields and historical growth rates underestimates expected returns relative to the total payout model. Finally, we demonstrate that the cyclically adjusted total yield (CATY) predicts changes in expected returns at least as well as the cyclically adjusted price-to-earnings ratio (CAPE).
Identifying the capabilities and limitations of crispr in targeting g-quadruplex forming sequences: from target recognition to gene expression regulation

Clustered regularly interspaced short palindromic repeats (CRISPR) and CRISPR associated proteins (Cas) have recently been at the forefront of genomic research due to their enormous potential at editing the genome with great precision and specificity. A world-wide effort is currently underway to test Cas proteins and their variants for applications geared towards genome editing for human cells. How CRISPR-Cas systems perform in editing sequences that form non-canonical DNA or RNA secondary structures or are in the vicinity of such structures is the problem we wish to pursue during the course of proposed studies. One such structure is the G-quadruplex (GQ), which has been demonstrated to form throughout the human genome, with particular concentration in telomeric sites, promoters, and 3’ and 5’ untranslated regions of RNA. The higher frequency of potentially GQ forming sequences (PQS) at such regulatory sites has suggested a potential role for these structures in transcription or translation level gene expression regulation. GQ formation has been demonstrated to inhibit gene expression for a number of different genes, including certain critical oncogenes. Inability to remove these structures is directly associated with several syndromes, including Bloom and Werner syndromes, and neurological disorders such as amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Therefore, editing such sequences to prevent GQ formation also has therapeutic potential. We will design different single guide RNA constructs and target the GQ forming G-rich or the complementary C-rich strand to elucidate the capabilities and limitations of the CRISPR-Cas9 system in editing such structures using single molecule techniques and bulk assays. We will then investigate whether CRISPR-Cas9 can be used to regulate gene expression by targeting GQ structures in the promoter region of tyrosine hydroxylase and c-Myc genes in the presence and absence of GQ stabilizing small molecules.
Device for a sliding switch

This description relates to a switch for controlling electrical equipment in an automotive vehicle, comprising a pivoted key (4) which is connected to the lid (2) of the switch and a circuit board (7) which is contained in the base (3), said pivoted key (4) being suitable for moving a mobile contact (9) on the said circuit board (7) in order to close electrical contacts (13) contained therein. The mobile contact (9) is contained in a sliding element (10) which is connected to the pivoted key (4) by a mechanism for transforming the pivoted motion.
Real-Time Binaural Sound Source Localization Using Sparse Coding and SOM

AbstractThis paper presents a binaural sound source localization method using both a sparse coding and a self-organizing map (SOM) in real-time system. We use the sparse coding for feature extraction to estimate the azimuth of sound source. It is used for decomposing input sound signals into three components such as time, frequency and magnitude. Therefore, although the frequency characteristic of ITD (Interaural Time Difference) is changed by shape of head, we utilized it to estimate the azimuth of the sound source considering the time-frequency features simultaneously. Then we adapted the SOM to estimate the azimuth of sound source which is a type of artificial neural networks. This system is constructed by open-source software, Flowdesigner, which gives us a data-flow oriented developmental environment for efficient real-time system.Keywordsreal-time binaural sound source localizationsparse codingSOMflowdesigner
COMPOSITE NONWOVEN WITH IMPROVED DIMENSIONAL RECOVERY

This invention relates to a micro-creped composite nonwoven having improved dimensional and thermal recovery (low distortion) allowing it to continuously adjust 5 under dynamic end use conditions. This product incorporates the following properties: ease of extension, absorbency, breathability, launderability, stitch holding, strength and web uniformity. The end uses envisioned for this type of product include waistband and other interliners for the apparel market, sports and medical tapes, wraps and bandages, and functional packaging materials.
CONSIDERAÇÕES SOBRE A OCUPAÇÃO DE VAGAS COTISTAS EM UMA INSTITUIÇÃO PÚBLICA NO NORTE DO ESTADO DO PARANÁ

RESUMO: A história do Brasil é marcada por políticas públicas que conduziram à uma desigualdade socioeconômica relacionada com a cor da população. Reflexo deste processo é a participação desigual dos indígenas e negros na escolarização. Para diminuir esta situação, em 2012 o governo lançou a lei 12711, a qual destinou 50% das vagas de instituições públicas para alunos advindos da rede pública. As cotas são de extrema importância para o país mitigar a desigualdade étnico-social, democratizando oportunidades para grupos sociais excluídos. Esta pesquisa apresenta dados de ocupação de vagas dessas populações em uma instituição de ensino do Paraná no período 2013-2020. Os dados revelam que parte destas vagas não são preenchidas, talvez, por ausência de políticas institucionais de divulgação.&#x0D; Palavras-chaves: Lei de cotas. Universidade pública. Ocupação de vagas.
Translation under constraint: censorship in the islamic republic of iran

The indispensable status of translation and translators in Iran, the availability of multiple translations of the same works, and the strict censorship imposed by the government on translators make the Iranian situation a promising object of translational research, well beyond its areal provenance. The proposed research will try to describe the main characteristics of the particular field of literary translation in Iran by analyzing the dynamics between different role players competing with each other in this field. It will then try to explore the true nature of limitations and constraints that Iranian translators are exposed to and discover different strategies that they use in practice to deal with these limitations and constraints. To this end, an English novel and its multiple Persian translations will be carefully examined in the light of information obtained from interviews that will be conducted with the Iranian translators of the novel.
ROUTING PROTOCOL SELECTION FOR AN AD HOC NETWORK

An ad hoc network includes a set of nodes. Each nodes may include one or more routing protocol (Fig. 3) that are available for use by the node. A source node (120) in the network attempting to transmit a message to a destination node (150) in the network may need to establish a common routing protocol between nodes in the network. The source node (120) can transmit a request for routing protocol information to a limited number of nodes in the network. The limited number of nodes may include nodes in zone with a radius length determined by a predetermined number of hops from the source node (120). The source node receives the routing protocol information from the limited number of nodes and selects a common routing protocol based on the received information. The source node (120) transmits the selected common routing protocol to all nodes in the network.
Sensitivity studies and stochastic optimization of CO2 foam flooding

The use of CO 2 foam flooding for enhanced oil recovery is increasingly becoming common. In this type of enhanced oil recovery, the surfactant is dissolved into CO 2 to form foam and the CO 2 foam is injected alternately with water to improve the sweep efficiency of the flood. However, many parameters affect the effectiveness of this CO 2 flood. Some of these parameters are the concentration of surfactant dissolved in the CO 2, the ratio of the foam injection time to the water injection time (cycle ratio), etc. Large savings in cost can be realized if these parameters are carefully selected. In this work, we optimized CO 2 foam flooding by estimating the parameters that affect the flooding using stochastic optimization algorithms. First, we performed some sensitivity studies to determine the extent of influence of different parameters of the CO 2 foam flood. From the sensitivity studies, we were able to reduce the number of parameters to be optimized to three (cycle ratio, surfactant concentration, and well locations) that have significant effects on the flood. Subsequently, we adopted two optimization algorithms to estimate the three parameters.
TOWER CASSETTE

A printer cassette device (9) is arranged to be removably mounted to or inserted into a printing device of a weighing scale (2). The printer cassette device (9) comprises a rotatable locking mechanism for rotational engagement with the printing device.
Diagnosis of embankment dam distresses using Bayesian networks. Part II. Diagnosis of a specific distressed dam

Based on prior information on common characteristics of dam distresses extracted from the dam distress database described in a companion paper, this paper attempts to extend the technique of Bayesian networks to the diagnosis of a specific distressed dam. The diagnosis is conducted by combining two sources of information, i.e., global-level knowledge from the database and project-specific evidence. Based on results of the diagnosis, key distress factors for a specific dam can be identified and suitable remedial measures can be suggested. Further, the Bayesian network analysis is conducted to evaluate the effectiveness of the adopted remedial measures. A case study on the diagnosis of a distressed embankment dam, Chenbihe Dam, with seepage problems is presented to illustrate the methodology. In this case study, the observed leakage rates, seepage exit locations, and boundary conditions of the embankment are used as project-specific evidence.
Sull’identità civica di Apollonia di Cirenaica

Si vuole dimostrare che Apollonia di Cirenaica non fu né una fondazione indipendente, né una vera e propria subcolonia, piuttosto uno scalo marittimo: “il porto di Cirene”, dove trovavano sede installazioni portuali e militari; abitata fra l’età arcaica e quella ellenistica da mercanti e artigiani, guarnigioni e personale marittimo. Seguire il suo sviluppo civico è di estremo interesse: frequentata dai membri della corte alessandrina, diviene polis autonoma con proprie istituzioni col passaggio alla dominazione romana, poi capitale della Libya superior a metà del IV sec. d.C., e in quanto tale oggetto della munificenza imperiale. Nonostante momenti di dissidio non perderà mai del tutto il legame privilegiato con Cirene.
Enhancing research in ageing at the university of coimbra

The project “Enhancing Research in Ageing at the University of Coimbra” (ERA@UC) addresses the Widespread ERA Chair call to promote excellence in science research in low-performing EU Member States, thus reducing disparities across Europe. ERA@UC will attract to the University of Coimbra (UC) a high-level leading scientist, and research team, in the field of ageing research, to develop world-leading research, advanced teaching and foster institutional governance changes towards excellence and sustainability.UC is the leader of Ageing@Coimbra,
European Innovation Partnership on Active and Healthy Ageing (EIP-AHA) Reference Site. In Coimbra and Centro Region of Portugal, science and technology are major drivers of socioeconomics development and the major instrument to tackle the societal challenge related with population ageing (> 22% of +65 old people in Centro Region). UC encloses excellence resources in biomedical research, advanced teaching, health care and innovation, especially in Ageing, Neuroscience and Vision. However, to further potentiate the outcomes of this knowledge and innovation ecosystem, further investment is crucial to leverage the quality of fundamental science to world leading standards. ERA@UC will contribute to this mission by contracting a key scientific leader with proven expertise in management, leadership and excellence research in ageing, taking advantage of human stem cells. This focus area reduces the economic and ethics impact of fundamental research in ageing, delivers outstanding discoveries in ageing mechanisms and encloses key scientific leaders with the adequate profile for ERA@UC position. ERA