SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Preconceptual Folic Acid Use and Recurrence Risk Counseling for Congenital Heart Disease

Objective

Recurrence risk of congenital heart disease (CHD) in families with an affected first-degree relative is increased as compared with the general population. Advances in genetic testing and evidence that preconceptual folic acid supplementation may decrease risk of CHD warrant preventative counseling for at-risk families. Our goal was to document patterns of preconceptual folic acid supplementation and recurrence risk counseling in at-risk families in order to identify opportunities for improved preventative care.



Design

Mothers referred for a fetal echocardiogram were prospectively enrolled. Cases were defined as mothers deemed to be at higher risk of having an affected fetus with CHD given an affected parent or affected previous pregnancy with CHD. Controls were defined as mothers with no prenatal risk factors. Mothers completed a validated questionnaire assessing use of folic acid supplementation and receipt of recurrence risk counseling. Chi-square analyses were performed to analyze questionnaire responses and demographic data.



Results

A total of 314 subjects participated (controls = 216, cases = 98). Cases took preconceptual folic acid supplementation more often than controls (P < .001), but only 55% started preconceptually. Maternal advanced education and counseling (P < .001) were associated with preconceptual supplementation, whereas complexity of CHD in the relative was not. While 70% of cases received some recurrence risk counseling, those with advanced education and complex CHD in the affected relative were more likely to receive counseling. Few at-risk cases interacted with genetic services (19%).



Conclusions

At-risk mothers with lower education are less likely to take preconceptual folic acid supplementation or receive recurrence risk counseling. Health care providers should proactively provide this information to all at-risk patients and develop collaborations with genetic services.
Magnetic drive bypass system for paintball loader

A drive system for a regulating the rotation of a drive system or agitator in a paintball loader is disclosed. It is designed to regulate the rotation of a feeder, especially during a jam or when projectiles in a hopper become misaligned. This allows a user to quickly and effectively clear a jam and resume or continue rapid fire without damaging projectiles, the loader or the paintball marker.
Weakly coupled non-Abelian anyons in three dimensions

We introduce a Hamiltonian coupling Majorana fermion degrees of freedom to a quantum dimer model. We argue that, in three dimensions, this model has deconfined quasiparticles supporting Majorana zero modes obeying nontrivial statistics. We introduce two effective field theory descriptions of this deconfined phase, in which the excitations have Coulomb interactions. A key feature of this system is the existence of topologically non-trivial fermionic excitations, called "Hopfions" because, in a suitable continuum limit of the dimer model, such excitations correspond to the Hopf map and are related to excitations identified in arXiv:1003.1964. We identify corresponding topological invariants of the quantum dimer model (with or without fermions) which are present even on lattices with trivial topology. The Hopfion energy gap depends upon the phase of the model. We briefly comment on the possibility of a phase with a gapped, deconfined $\mathbb{Z}_2$ gauge field, as may arise on the stacked triangular lattice.
Protecting the Enclosed Parts of the Sea in Adriatic from pollution

Adriatic area will get an innovative response system for most endangered parts of sea with strong and original planning and applicative solutions. Detailed contingency plans will examine EPSs in order to define risks, needed approaches and equipment. For application of plans in case of incident, new technological solution will be developed that is adjusted to EPS’ features affecting the pollution delimiting and cleaning. Project will produce following outputs: adequate and timely approach for responding to sea pollution risk and incidents in EPSs based on detailed contingency plans; developed and tested technological solution and equipment for response in phases; training programmes for response teams and awareness campaigns for considerate use of sea.
Distribution analysis of population structures forRhizoctonia solaniAG-1 IA in Japanese paddy field, using rep-PCR assay

In the present study, characterisation of genotypic variations of Rhizoctonia solani AG-1 IA associated with rice sheath blight by Rep-PCR assay and their structure of the genotypic variations by monitoring vertical and horizontal movements of their populations at a short distance level were investigated in Japanese paddy fields. Differences of the Rep-PCR fingerprintings were observed and distinguished into four genotypic variations referred to as GI, GII, GIII and GIV, respectively. Although similarity index of each genotype showed high levels of homology (85–90%) within the same genotypes, low levels of similarity index (65–70%) were also varied among the comparison of different genotypes. Moreover, diversity of genotypic populations was observed which is consistent with the correlations between the geographical undulations of the paddy fields and the occupation of their genotypic populations, indicating the presence of genotype GI on low lands such as AK1 and also the presence ofgenotype GIV on high l...
F-theory and all things rational: surveying U(1) symmetries with rational sections

We study elliptic fibrations for F-theory compactifications realizing 4d and 6d supersymmetric gauge theories with abelian gauge factors. In the fibration these U(1) symmetries are realized in terms of additional rational sections. We obtain a universal characterization of all the possible U(1) charges of matter fields by determining the corresponding codimension two fibers with rational sections. In view of modelling supersymmetric Grand Unified Theories, one of the main examples that we analyze are U(1) symmetries for SU(5) gauge theories with \bar{5} and 10 matter. We use a combination of constraints on the normal bundle of rational curves in Calabi-Yau three- and four-folds, as well as the splitting of rational curves in the fibers in codimension two, to determine the possible configurations of smooth rational sections. This analysis straightforwardly generalizes to multiple U(1)s. We study the flops of such fibers, as well as some of the Yukawa couplings in codimension three. Furthermore, we carry out a universal study of the U(1)-charged GUT singlets, including their KK-charges, and determine all realizations of singlet fibers. By giving vacuum expectation values to these singlets, we propose a systematic way to analyze the Higgsing of U(1)s to discrete gauge symmetries in F-theory.
A Prospective Study of Ideal Cardiovascular Health and Depressive Symptoms

Ideal cardiovascular health is a new construct defined by the American Heart Association as part of its 2020 Impact Goal.The purpose of this study was to examine whether the simultaneous presence of ideal cardiovascular health behaviors and factors could reduce the odds of developing depressive symptoms.Participants from the Aerobics Center Longitudinal Study, who did not have any mental disorder/condition at baseline, were examined between 1987 and 1998, and they were followed up for a mean period of 6.1 years. Ideal cardiovascular health behaviors (never smoking, body mass index <25kg/m(2), physical activity at goal, and appropriate diet consistent with guideline recommendations) and factors (total cholesterol <200mg/dL, blood pressure <120/80mm Hg, and fasting blood glucose <100mg/dL) were measured at baseline. Depressive symptoms were assessed using the 10-item Center for Epidemiologic Studies Depression Scale in 1990, 1995, or 1999.Of the 5110 participants, 641 reported depressive symptoms. Participants meeting 3-4 or 5-7 ideal cardiovascular health components had 28% (odds ratio = 0.72; 95% confidence interval 0.59-0.87) and 36% (odds ratio = 0.64; confidence interval 0.50-0.82) decreased odds of depressive symptoms, respectively, when compared with those meeting 0-2 ideal components. Ideal behaviors were associated with lower odds of depressive symptoms in participants meeting 2 or 3-4 ideal behaviors, compared with those meeting 0-1 (odds ratio = 0.81; confidence interval 0.67-0.98 and odds ratio = 0.72; confidence interval 0.57-0.91). Ideal factors were not associated with depressive symptoms.Ideal cardiovascular health components, especially health behaviors, present an inverse relationship with depressive symptoms.
SPINDLELESS SPINNING MACHINE

A spindleless spinning machine has a carcass (1) with a rotation drive, spinning assemblies, a yarn removing unit (2) and a yarn winding mechanism (3), all being mounted on the carcass. Each spinning assembly comprises fibre feeding unit (4) and a spinning chamber (5) with a casing (14) mounted on the carcass (1) with the possibility of its removal from the fibre feeding unit (4). The yarn removing unit (2) contains a driving shaft (22) mounted on the carcass (1) and pressure rollers (23) resiliently pressed to the driving shaft (22) in their working position and mounted with the possibility of their removal from the said driving shaft (22). Each yarn winding mechanism (3) is located against the corresponding spinning assembly and contains a bobbin holder (27) and a yarn layer (28). Each pressure roller (23) is mounted on the casing (14) of the corresponding spinning chamber (5), whereas each yarn winding mechanism (3) is provided with a kinematic link (31) with the casing (14) of the corresponding spinning chamber (5) for the purposes of switching on and off the rotation drive, that kinematic link being a double-arm Y-shaped lever (32) one of the arms of which is pressed to the bobbin holder (27) and another - to the casing (14) of the spinning chamber (5). Each pressure roller can be put into a rubbing contact with both a conoid drum and the driving shaft (22) at the same time.
“I'm Happy to Be Able to Help:” Why Women Donate Milk to a Peer via Internet-Based Milk Sharing Networks

The process by which women came to donate milk via online milk sharing networks was explored via a questionnaire administered to 97 peer milk donors. Seventy-one respondents stated that they were motivated to donate milk because they wanted to help someone. Many described milk donation as an empathic response to women with insufficient milk. Seventy-four respondents donated milk that they had previously expressed but did not need. Their desire to ensure that their milk was not wasted contributed to their decision to donate. Fifty-one respondents expressed milk specifically for donation, including 20 donors who initially donated previously expressed surplus milk but then expressed milk specifically for recipient peers. The motivations of peer-to-peer donors are the same as those reported for women donating to a milk bank. Respondents who donated previously expressed milk had originally expressed so they had milk when separated from their baby, to manage an overabundant milk supply, because their baby was unwilling or unable to breastfeed, in case of emergency, and to maintain milk supply. This study is the first to clearly identify that some women express milk because they believe this is required for milk supply maintenance. Peer milk donors appeared satisfied with their experience of donating milk. The importance of altruistic motivation should be considered in discussions of the desirability of financial compensation for milk donation. Further research is needed on why women express their milk and whether such expression is beneficial to them.
Climate-change-driven growth decline of European beech forests

The growth of past, present, and future forests was, is and will be affected by climate variability. This multifaceted relationship has been assessed in several regional studies, but spatially resolved, large-scale analyses are largely missing so far. Here we estimate recent changes in growth of 5800 beech trees (Fagus sylvatica L.) from 324 sites, representing the full geographic and climatic range of species. Future growth trends were predicted considering state-of-the-art climate scenarios. The validated models indicate growth declines across large region of the distribution in recent decades, and project severe future growth declines ranging from -20% to more than -50% by 2090, depending on the region and climate change scenario (i.e. CMIP6 SSP1-2.6 and SSP5-8.5). Forecasted forest productivity losses are most striking towards the southern distribution limit of Fagus sylvatica, in regions where persisting atmospheric high-pressure systems are expected to increase drought severity. The projected 21st century growth changes across Europe indicate serious ecological and economic consequences that require immediate forest adaptation.
Quantum Engineering of a Low-Entropy Gas of Heteronuclear Bosonic Molecules in an Optical Lattice

We demonstrate a generally applicable technique for mixing two-species quantum degenerate bosonic samples in the presence of an optical lattice, and we employ it to produce low-entropy samples of ultracold 87Rb133Cs Feshbach molecules with a lattice filling fraction exceeding 30%. Starting from two spatially separated Bose-Einstein condensates of Rb and Cs atoms, Rb-Cs atom pairs are efficiently produced by using the superfluid-to-Mott insulator quantum phase transition twice, first for the Cs sample, then for the Rb sample, after nulling the Rb-Cs interaction at a Feshbach resonance's zero crossing. We form molecules out of atom pairs and characterize the mixing process in terms of sample overlap and mixing speed. The dense and ultracold sample of more than 5000 RbCs molecules is an ideal starting point for experiments in the context of quantum many-body physics with long-range dipolar interactions.
A PROCESS FOR PREPARATION OF FOSAPREPITANT DIMEGLUMINE AND AN INTERMEDIATE THEREOF

The present invention relates to a novel process for the preparation of intermediate of fosaprepitant dimeglumine. The present invention particularly relates to a process for the preparation of fosaprepitant dibenzyl ester, an intermediate of fosaprepitant dimeglumine, which is simple, easy to handle on commercial scale and efficient.
Design and integration of graphene fibre based antennas for smart textiles

Smart textiles that provide a seamless command-oriented user interface and have capable of wireless communication, have become active research field in recent decades with interest of wearable and attractive platforms. Well-known mechanical requirements such as light weight, compactness, and flexibility, that smart components should be invisibly and unobtrusively integrated into a garment to ensure the wearer’s comfort. GFSMART aims to develop graphene fibre based antennas for smart textiles that pushes the state-of-the-art in wireless body-centric systems, by utilizing traditional textile manufacturing techniques. Wearable antenna will be developed based on the merits of graphene as a flexible, conductive fibres. GFSMART project does not only involve implementation of novel materials and wearable electronics but also embraces design strategies of smart adaptive garments for people affected by dementia and Alzheimer’s disease. The proposal hosting by Royal College of Art (RCA), will involve collaboration with other EU universities, which will increase the impact of the developed results on the textile industry and enable my career restart in European research zone. GFSMART will lead to first implementation of graphene fibres in wearable antenna design and later in designing smart garments for people affected by dementia and Alzheimer’s disease. I have extensive experience on carbon nanomaterials and novel materials for textile applications and published more than 30 critically acclaimed journal and conference papers, patents in this subject. Through this innovative multidisciplinary research and with the help of experimental infrastructure provided by the RCA, as a newly appointed senior tutor in smart textiles at RCA, I am expected to gain maturity in managing research projects and advance my career toward being an esteemed professor in the field of smart textiles in Europe.
TU-CD-207-11: Patient-Driven Automatic Exposure Control for Dedicated Breast CT

Purpose: To implement automatic exposure control (AEC) in dedicated breast CT (bCT) on a patient-specific basis using only the pre-scan scout views. Methods: Using a large cohort (N=153) of bCT data sets, the breast effective diameter (D) and width in orthogonal planes (Wa,Wb) were calculated from the reconstructed bCT image and pre-scan scout views, respectively. D, Wa, and Wb were measured at the breast center-of-mass (COM), making use of the known geometry of our bCT system. These data were then fit to a second-order polynomial “D=F(Wa,Wb)” in a least squares sense in order to provide a functional form for determining the breast diameter. The coefficient of determination (R2) and mean percent error between the measured breast diameter and fit breast diameter were used to evaluate the overall robustness of the polynomial fit. Lastly, previously-reported bCT technique factors derived from Monte Carlo simulations were used to determine the tube current required for each breast diameter in order to match two-view mammographic dose levels. Results: F(Wa,Wb) provided fitted breast diameters in agreement with the measured breast diameters resulting in R2 values ranging from 0.908 to 0.929 and mean percent errors ranging from 3.2% to 3.7%. For all 153 bCT data sets used in this study, the fitted breast diameters ranged from 7.9 cm to 15.7 cm corresponding to tube current values ranging from 0.6 mA to 4.9 mA in order to deliver the same dose as two-view mammography in a 50% glandular breast with a 80 kV x-ray beam and 16.6 second scan time. Conclusion: The present work provides a robust framework for AEC in dedicated bCT using only the width measurements derived from the two orthogonal pre-scan scout views. Future work will investigate how these automatically chosen exposure levels affect the quality of the reconstructed image.
Association control algorithms for handoff frequency minimization in mobile wireless networks

As mobile nodes roam in a wireless network, they continuously associate with different access points and perform handoff operations. Frequent handoffs performed by a mobile device may have undesirable consequences, as they can cause interruptions for interactive applications and increase the energy usage of mobile devices. While existing approaches to this issue focus entirely on improving the latency incurred by individual handoffs, in this paper, we initiate a novel approach to association control of mobile devices with the goal of reducing the frequency of handoffs for mobile devices. We study the handoff minimization problem across multiple dimensions: offline versus online where the complete knowledge of mobility patterns of users is known in advance or unknown respectively; capacity constrained versus unconstrained access points, which imposes limits on the number of mobile devices which could be associated with a given access point at any given point in time; group mobility versus arbitrary mobility of users, which are contrasting ways to model the mobility patterns of the mobile users. We consider various combinations of the above dimensions and present the following: (1) optimal algorithms, (2) provably-good online and offline approximation algorithms, (3) complexity (NP-Completeness) results, and (4) a practical heuristic which is demonstrated to work well on real network traces.
Components of gating charge movement and S4 voltage-sensor exposure during activation of hERG channels

The human ether-á-go-go–related gene (hERG) K+ channel encodes the pore-forming α subunit of the rapid delayed rectifier current, IKr, and has unique activation gating kinetics, in that the α subunit of the channel activates and deactivates very slowly, which focuses the role of IKr current to a critical period during action potential repolarization in the heart. Despite its physiological importance, fundamental mechanistic properties of hERG channel activation gating remain unclear, including how voltage-sensor movement rate limits pore opening. Here, we study this directly by recording voltage-sensor domain currents in mammalian cells for the first time and measuring the rates of voltage-sensor modification by [2-(trimethylammonium)ethyl] methanethiosulfonate chloride (MTSET). Gating currents recorded from hERG channels expressed in mammalian tsA201 cells using low resistance pipettes show two charge systems, defined as Q1 and Q2, with V1/2’s of −55.7 (equivalent charge, z = 1.60) and −54.2 mV (z = 1.30), respectively, with the Q2 charge system carrying approximately two thirds of the overall gating charge. The time constants for charge movement at 0 mV were 2.5 and 36.2 ms for Q1 and Q2, decreasing to 4.3 ms for Q2 at +60 mV, an order of magnitude faster than the time constants of ionic current appearance at these potentials. The voltage and time dependence of Q2 movement closely correlated with the rate of MTSET modification of I521C in the outermost region of the S4 segment, which had a V1/2 of −64 mV and time constants of 36 ± 8.5 ms and 11.6 ± 6.3 ms at 0 and +60 mV, respectively. Modeling of Q1 and Q2 charge systems showed that a minimal scheme of three transitions is sufficient to account for the experimental findings. These data point to activation steps further downstream of voltage-sensor movement that provide the major delays to pore opening in hERG channels.
ANTIMICROBIAL AND ANTIVIRAL NANOCOMPOSITES SHEETS

Antimicrobial textiles and methods of making antimicrobial textiles including a sheet substrate comprising a textile and metal oxide nanoparticles in which the nanoparticles are present as a nanocomposite on the surface of and within the sheet substrate. The textiles may be used in wearable items such as personal protective equipment such as face masks. Methods of making the textiles include applying a metal salt solution to a textile to diffuse the metal salt into the textile and drying the textile, such as drying the textile with heat, to bind the metal salt to the surface of and the interior fibers of the textile by forming a nanocomposite of metal nanoparticles or nanostructures in situ.