SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
A synergistic approach toward understanding receptor signaling in the cell at very high resolution

Members of the Epidermal Growth Factors Receptor family (EGFRs) influence cell growth and proliferation, and are pivotal in all phases of tumor progression. We will use this receptor family as an example with which to develop a ground-breaking new technology to study cellular signaling towards atomic resolution, in situ. Therefore, we propose to employ an interdisciplinary approach for studying EGFR family of receptors, where we follow their conformational and oligomeric states as well as bound ligands and signal transduction molecules during different activation states at atomic resolution in situ. We will progress from engineered to native receptor forms, and from defined membrane vesicles to whole cells, and employ 3D structure analysis by cryo-electron tomography, greatly enhanced by novel image processing approaches, mass spectroscopy definitions of receptor modifications and interaction partners, as well as advanced protein engineering to identify, orient and freeze receptors for this method development. This collaborative project addresses the properties of the EGFR family across a wide range of complexity and dimensions, in the cellular environment, through their high-resolution structures and changes during receptor recycling. This collaborative network, addressing EGFR from complementary angles, is most likely to generate substantial new information on these assemblies and to yield a deep understanding of the mechanisms underlying their structure and function. The EGFR family has been the focus of many tumor therapies, with the aim of intercepting their signaling, and this project will contribute to a more detailed understanding of their mode of action and thus the more rational development of such therapies in the future. However, the technology that will be developed will be generally applicable and may thus help to contribute to a paradigm change for structural biology, enabling atomic resolution description of receptors in their cellular environment.
A new hynobiid-like salamander (Amphibia, Urodela) from Inner Mongolia, China, provides a rare case study of developmental features in an Early Cretaceous fossil urodele

A new fossil salamander, Nuominerpeton aquilonaris (gen. et sp. nov.), is named and described based on specimens from the Lower Cretaceous Guanghua Formation of Inner Mongolia, China. The new discovery documents a far northern occurrence of Early Cretaceous salamanders in China, extending the geographic distribution for the Mesozoic fossil record of the group from the Jehol area (40th–45th parallel north) to near the 49th parallel north. The new salamander is characterized by having the orbitosphenoid semicircular in shape; coracoid plate of the scapulocoracoid greatly expanded with a convex ventral and posterior border; ossification of two centralia in carpus and tarsus; and first digit being about half the length of the second digit in both manus and pes. The new salamander appears to be closely related to hynobiids, although this inferred relationship awaits confirmation by research in progress by us on a morphological and molecular combined analysis of cryptobranchoid relationships. Comparison of adult with larval and postmetamorphic juvenile specimens provides insights into developmental patterns of cranial and postcranial skeletons in this fossil species, especially resorption of the palatine and anterior portions of the palatopterygoid in the palate and the coronoid in the mandible during metamorphosis, and postmetamorphic ossification of the mesopodium in both manus and pes. Thus, this study provides a rare case study of developmental features in a Mesozoic salamander.
Magnetism and the effects of electric field

MagnEFi is a training network of European experts assembled to provide enhanced training and education to early stage researchers on the topic of electric field effects on nanoscale magnetic structures. The goal is to train the next generation to work in this fast rising and key field of GreenIT. Electric fields may be applied to nanoscale magnetic structures in a variety of ways: either directly as a voltage gate, coupled via a ferroelectric or piezoelectric material that strains the nanomagnet, or using light. Addressing the effect of electric fields on the properties of nanoscale magnetic structures has become increasingly important in the search for efficient methods of manipulating nanomagnetism. Research in this area is expected ultimately to lead to ultralow power devices for computation and communication with new functionalities.
The consortium that has come together to deliver this training is uniquely qualified to do so, consisting of world-leading experts in condensed matter physics and leading private companies, along with a range of associated partners spanning basic research, machine tool development, industrial and consumer products. The consortium provides a rich training environment that is both international and intersectoral, where the fellows will both study at the cutting edge of science and technology, and also come to appreciate the breadth of the field in terms of its intellectual challenges, commercial concerns and relationship to society’s need for ever more powerful information technologies with a reduced environmental footprint. This will enable them, in their future careers, to contribute to the strengthening of both the European Research Area and the European Information and Communication industry, particularly GreenIT, an especially important and growing sector for EU economic development.
Tout le monde compte — Personnes vulnérables

Pour prévenir l’exclusion sociale et briser le cycle des désavantages, atteindre les personnes vulnérables qui risquent de tomber à travers les fissures des systèmes. Leur permettre de devenir des membres à part entière de leurs communautés économiques et sociales. Apporter un changement de système pour s’assurer que personne n’est laissé pour compte, en changeant les mentalités des responsables de la prestation des services. Fournir des éléments probants à l’appui du déploiement plus large de cette approche réussie et rentable.
(19474.04112021.194000099) THE MINE 2021

WITH THIS PROJECT, THE COMPANY WANTS TO OVERSEE MORE THE TWO TARGET TARGET MARKETS (UNITED STATES AND UK), THROUGH TRADE FAIR EXPENSES, IMPLEMENTATION OF COMMUNICATION ACTIONS FOR ACTIVITIES? BRANDING AND MARKET RESEARCH IN THE UK TO START AN ENTRY ACTION ON THIS MARKET.
Workers, farmers and Catholicism: A history of political class coalitions and the south-European welfare state regime

The explanatory model behind Esping-Andersen’s ‘three-regime’ typology points to the variance in ‘political coalition building in the transition from a rural economy to a middle-class society’, particularly to whether or not farmers and workers were able to form coalitions during this transition. The article reconsiders the relation between party systems and welfare state regimes. It highlights the systematic variation among European party systems with respect to the electoral success of communist parties. The electoral strength of communist parties is argued to be related to the intensity of past conflicts between the nation-state and the Catholic church in the mono-denominational countries of Europe’s south. These conflicts rendered a coalition between pious farmers and the anticlerical worker’s movement unthinkable and furthered the radicalization of the left. The article argues that the split on the left explains much of what is distinctive about southern Europe’s postwar political economies.
Faire sa jeunesse dans les rues de Ouagadougou

À Ouagadougou, les jeunes hommes qui vivent et dorment dans les rues s’appellent les bakoroman. Mais le plus souvent, et bien qu’ils n’aiment pas ça, on les appelle les « enfants de la rue ». Par le vol, la mendicité et les petits boulots, les bakoroman s’insèrent dans différentes niches de l’économie urbaine qui leur garantissent la survie au quotidien mais aussi l’accès à la modernité et aux loisirs, voire l’envoi occasionnel d’argent à leurs parents. La mobilité juvénile masculine const...
Study of the trophic state and anomalies in the Upper Adriatic system

Two are the objectives of this project, namely the description of seasonal variability of the benthic and pelagic systems in a semiconfined environment such as the Gulf of Trieste, that is subject to seasonally-variable river contributions; and the understanding of the processes leading to the production of dissolved organic matter (DOM), whose aggregation produces gelatinous macro aggregates. The activities carried out include the monitoring of abiotic and biotic characteristics of benthic and pelagic systems, the experimental estimate of carbon flows, experiments in mesocosms on the bacterial and viral components, and the creation of a database and of the Geographic Information System (GIS) on paper and multimedia supports. The main scientific objectives of the project are the definition of the trophic state of the system and its fluctuations at short time intervals (continuously for 5 years, so as to outline the interannual fluctuations in order to detect the main physical forcing agents), the detection of the factors that trigger off the main anomalies of the system (the ones that lead to the onset of detrimental phenomena or that prevent the proper fruition of environmental resources) and, lastly, the project aims at quantifying the carbon flows within the benthic and pelagic systems. The analyses also regard the definition of the biological bearing capacity of the system, the assessment of the trophic and functional relations between the benthic and pelagic systems, the isolation and the detection of the main producers of dissolved jelly-like matter, the experimental detection of physical, chemical and/or biological factors that engender the production of jelly-like matter, the definition of the viral component role in the onset of anomalies observed in the system and the modelling of the main biogeochemical processes that are typical of the system.
Chemical building blocks from versatile msw biorefinery

PERCAL will exploit Municipal Solid Waste (MSW) as feedstock to develop intermediate chemical products at high yield and low impurity level with huge industrial interest. These will be complementary to the bioethanol (current PERSEO technology), to achieve a cascade valorisation of the MSW components, i.e.:
• Lactic acid (LA) to produce: 1) Eco-friendly ethyl lactate solvents by reactive distillation from lactic acid & bio-ethanol to be used in cleaning products and inks and 2) hot-melt adhesives for cardboard and other non-food applications in combination with maleic anhydride by reactive extrusion.
• Succinic acid (SA) as an intermediate building blocks to production of polyols for the polyurethane industry.
• Biosurfactants by chemical and/or microbiological modification of protein and lipid fraction from remaining fraction of MSW fermentation.
IIn order to minimize the MSW heterogeneous composition (due to seasonal and origin variability driven by local economic, social and climate conditions) limitations as a fermentation feedstock, four main innovations will be proposed: i) New enzymatic cocktails to maximize hydrolysis of fermentable organic matter with low inhibitors production, ii) the use of high yield, specific and robust strains for each selected acid, iii) the extraction of fermentation by-products acting as inhibitors to succinic acid production via novel membrane electrolysis employing an integrated continuous fermentation coupled with simultaneous organic acid removal in comparison with SA sequential fermentation followed by its separation using an electrodialysis-based and iv) optimize simultaneous saccharification and fermentation for lactic acid production followed by a downstream separation process based on membrane electrodialysis. To maximize the yield and purity of target organic acids, continuous and single step fermentation process will be prioritized in order to allow their integration in the PERSEO plant.
The Core Degree Based Tag Reduction on Chip Multiprocessor to Balance Energy Saving and Performance Overhead

AbstractTag reduction is an approach to save energy of the cache system in a processor. Our previous work described that it can save more energy on a Chip Multiprocessor (CMP) than on a single-core processor. In this paper, we further investigate the problem on balancing energy saving and performance overhead when tag reduction is used for the low power Chip Multiprocessor (CMP). We first introduce the core degree concept which is defined as the number of cores that tag reduction can use for each thread. We then propose a core degree based tag approach that is to optimize the core degree such that the best balance of energy and performance can be achieved. In particular, as the basis for such optimization, the theoretical upper bounds of the energy savings and performance overhead are decided as function of the core degree. In our experiments, we use a 16-core CMP for example. In order to obtain the energy consumption and performance overhead with various core degrees, we construct an experimental environment, which is based on the Linux operating system. With the experimental environment, benchmarks of SPEC CPU2006 are used to evaluate our core degree based tag reduction. Finally, the experimental results show that the most desired balance of energy saving and performance overhead is achieved when core degree is set to 6.KeywordsEnergy ConsumptionEnergy SavingTime SlicePhysical MemoryPerformance OverheadThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
ANTIBACTERIAL EFFECT OF GLASS IONOMER AND ZINC OXIDE CHKM CEMENT AS ROOT CANAL FILLER TOWARD STREPTOCOCCUS VIRIDANS

Abstract Luting type glass ionomer cement (GIC) can be used as root canal filler. Because GIC has biocompatiblity and contained fluor, clinicians used zinc oxide ChKM (ZnOChKM) as root canal filler that contained parachorophenol, camper, and menthol. ChKM has a ability as wide spectrum antibacterial and low irritation. The Aim of study was to know antibacterial of luting type glass ionomer and zinc oxide ChKM as root canal filler toward Streptococcus viridans . This study was a laboratory experimental, contained of 7 samples of luting type GIC and 7 samples ZnOChKM cement. The characteristics were 2 mm of the thickness and 5 mm of diameter, non porous, homogen, and smooth. Each sample was taken in TSA medium that had been inoculated Streptococcus viridans . TSA medium was perforated by straw like the samples size. After samples were incubated for 1, 7, and 14 days, we measured inhibition zone around samples by caliper. All data was analyzed by T – test (α=0.05). The result showed that mean of ZnOChKM cement inhibition zone cement on the first day was 2.12 cm; seventh days was 2.46 cm; and 14 th days was 2.86 cm. Mean of GIC inhibition zone on the first day was 0.46 cm; seventh days was 1.18 cm; and 14 th days was 1.26 cm. ZnOChKM cement zone inhibition was large than GIC inhibition zone. T – test analysis showed there was significant different between ZnOChKM cement and luting type GIC in all observation time. In conclusion, ZnOChKM cement as a root canal filler was more effective than GIC to inhibit growth of Streptococcus viridans . Key words: luting type GIC, ZnOChKM, Streptococcus viridans
What is the appropriate size of the worldwide cord blood inventory?

In spite HLA polymorphism distribution has some variations between major ethnic groups, in a US study by Beatty et al. (Human Immunology, 2000), 10 000 donors provided a 4/6 HLA-match for patient in every group using the conventional CB match criteria (low resolution for HLA-A,-B and high resolution for HLA-DRB1). This was also shown in our UK study where 10 000 randomly selected donors allowed finding a match for almost all patients (Querol, Haematologica, 2009). For better match level (5/6) a bigger inventory was required but enlarging size showed a progressive decrease on its efficiency. Thus, only 5000 units were required to find a donor for 50% of patients; but to achieve 65%, we then need to triplicate size (15 000), and growth up to 50 000, to match 80%. Further increase has only marginal benefit. We can then speculate that an optimal world size inventory be the addition of fractions of 5–15 000 donors for each major ethnic group considered, depending on their anticipated diversity, to at least provide options of finding a 5/6 donor for more than half of the patients but assuring a 4/6 match donor for almost any of them. In addition, inter-ethnic cross matching and other HLA favorable interactions like use of HLA homozygous for mixed ethnicities, and consideration of Non-Inherited Maternal Antigen (NIMA) match effect, if confirmed, would further increase donor availability. If we consider 23 major ethnic groups as proposed by the allele frequency net database (Gonzalez-Galarza, Nucleic Acid Research 2011), a worldwide CB inventory would be in the region of 300 000 units. This would suffice to provide an optimal compatible donor for any patient in need. To be effective, all units within the inventory should be larger than 1·5E9 total nucleated cells (20% of those collected) to serve patients up to 100 kg using the double CBT strategy (threshold 1·5E7 TNC/kg). A central world cord blood bank may achieve this equalitarian goal with €300 million budget and a proper world distribution and size of regional collection programmes.
Decolonial enviromental justice: from the middle east and north africa to north america

DEJMENA—Decolonial Environmental Justice: from Middle East and North Africa to North America aims to provide a reading of environmental justice at the crosscut of indigeneity and feminist decoloniality. Drawing on local activists’ and indigenous communities’ struggles with environmental (in)justice, particularly land and water protection, across the Levant (Palestinian farmers in the South of the West Bank), North Africa (Amazigh communities in South-Western Morocco), and North America (Native Americans of the Lacota people in the Midwestern region of the US), this project aims to provide a novel and a much urgent grounding of the locally global impact and value of decolonial feminist environmentalism. DEJ-MENA is—to my knowledge—the first study that combines a decolonial feminist approach to the question of Environmental Justice (EJ) across these multiple locales of indigeneity. By creating a timely comparative understanding of decolonial EJ, DEJMENA will contribute to clarify the way in which evolving global EJ schemes—of which the EU is a major player—are connected to the restoration of indigenous rights in multiple locales. More specifically, it aims to contribute to major areas of EU policy and action (EU Climate action and the European Green New Deal; EU International Action on Climate Change). The ongoing Covid-19 pandemic has proved further the urgent need for more expansive theorising, research and action on EJ with indigenous communities by showing their huge vulnerability,  yet revealing the value of their ecologies. To accomplish this goal, DEJMENA will be undertaken in collaboration with three major academic institutions, Ca’ Foscari University of Venice (UNIVE), Colombia University (CU), and the London School of Economics and Political Science (LSE) and under the guidance and supervision of the most apt and internationally established scholars, Profs Matteo Legrenzi and Lila Abu-Lughod, and Dr Michael Mason.
Physical and Dynamical Meteorology

List of illustrations Some useful constants and units Introduction 1. The facts which call for explanation. A sketch of the surface distribution of the meteorological elements over the globe 2. Some statistical and thermal relationships 3. Water-vapour in the atmosphere. The ascent of damp air 4. Thermodynamics of the atmosphere 5. Radiation 6. Radiation in the troposphere 7. Radiative equilibrium and the stratosphere 8. The general equations of motion 9. Motion under balanced forces: the gradient wind 10. Surfaces of discontinuity 11. The general aspects of turbulence 12. Turbulence in the atmosphere: the eddies as diffusing agencies 13. The classification of winds 14. The transformations of energy in the atmosphere 15. The growth of cyclic circulations and of pressure inequalities in the atmosphere 16. The idea of air masses 17. The Polar front and its relation to the development of cyclones 18. Anticyclones 19. The general circulation of the atmosphere Appendix Index of names Index of subjects.
Development of Microplatforms to Mimic the In Vivo Architecture of CNS and PNS Physiology and Their Diseases

Understanding the mechanisms that govern nervous tissues function remains a challenge. In vitro two-dimensional (2D) cell culture systems provide a simplistic platform to evaluate systematic investigations but often result in unreliable responses that cannot be translated to pathophysiological settings. Recently, microplatforms have emerged to provide a better approximation of the in vivo scenario with better control over the microenvironment, stimuli and structure. Advances in biomaterials enable the construction of three-dimensional (3D) scaffolds, which combined with microfabrication, allow enhanced biomimicry through precise control of the architecture, cell positioning, fluid flows and electrochemical stimuli. This manuscript reviews, compares and contrasts advances in nervous tissues-on-a-chip models and their applications in neural physiology and disease. Microplatforms used for neuro-glia interactions, neuromuscular junctions (NMJs), blood-brain barrier (BBB) and studies on brain cancer, metastasis and neurodegenerative diseases are addressed. Finally, we highlight challenges that can be addressed with interdisciplinary efforts to achieve a higher degree of biomimicry. Nervous tissue microplatforms provide a powerful tool that is destined to provide a better understanding of neural health and disease.
Integrated approach for environmentally benign c-c coupling reactions

Pharmaceutical industry needs environmentally cleaner processes. One of the most important family of chemical reaction is the formation of carbon-carbon bond by Pd mediated C-C coupling. It is estimated, that more than 50% of new drug synthesis will include at least one C-C coupling reactions. However, there are several issues regarding this reaction related to high environmental impact, complicated processes due to air-sensitive catalyst, post-processing, solvent issues, and catalyst recovery. We have developed a new integrated approach for carrying out C-C coupling reactions in an environmental benign and cost-effective way. Our CC-Coupler method targets to overcome all the issues regarding the reaction. Our aim is to commercialise the CC-Coupler as an integrated technology, providing an air-stable, highly performant catalyst with an adequate flow-chemistry device and parameter set optimised for the clients’ needs. In this Phase 1 project, as a first step, we shall carry out a feasibility assessment. The success of this project will promote the growth of our company and make a step towards cleaner pharmaceutical industry.