SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
An amplified signal imaging software for prognosis of cancer enabling the evaluation of clinicalefficiency of personalised cancer treatments to an unprecedented level.

Chemotherapy remains the main treatment in locally advanced or metastatic lung cancer. The wide use of chemotherapies
is often lengthy (4 months) and is not supported by any patient stratification tools, leading to life-threatening risk. current
techniques used to identify biomarkers for target or immunotherapy (i.e. Immunohistochemistry and Protein Ligase Assays)
lack of sensitivity (up to 30% of false negatives) resulting in qualitative, subjective measurements with poor prognostic value.
iaFRET is an imaging system based on a proprietary time resolved Amplified Forester Resonance Energy Transfer (FRET)
technique. It determines both molecular and cell-cell interactions, enabling the evaluation of clinical efficiency of
personalised cancer treatments. iaFRET enables oncologists to define the most effective treatment for cancer case and
verify its efficacy anytime during the therapy. FASTBASE will need to finalise the engineering of the machine, optimize the
image analysis algorithms and user interface, conduct a clinical trial to demonstrate and validate the safety, efficacy and cost
savings of technology. Globally there are almost 300 research institutes and hospitals currently working on cancer research
worldwide, 147 in EU. Emerging frontiers like immunotherapy highly require technology like iaFRET. iaFRET can contribute
to European health system by improving the prognosis and treatment selection for cancer patients, hence increasing the life
expectancy of patients affected by this pathology.
Matchmaking restoration, ecology and aquaculture

Aquaculture  expansion is a necessary step to respond to increase protein demands while limiting the reliance on wild fisheries and imports.Bivalve aquaculture is considered to be one of the most sustainable, although some potentially negative environmental impacts arising from high deposition rates of faces and pseudofaces on the seabed have been identified.   Habitat restoration management can be integrated within aquaculture practices to limit their negative impacts and it can  bring  positive  environmental  changes while obtaining both economical and cultural returns.This  project aims to integrate  restoration with aquaculture, namely the  reintroduction  of  native  flat  Oyster reefs under mussels culture sites and harvest oyster spat recruiting as seeds in the original farm area to obtain economical returns and start a local oyster farming chain, while leaving the reef intact to provide ecosystem services.  The  main  aim  is  to  identify the best  practices for this integration,  in  terms  of  size,  stock  densities  and  environmental  conditions  necessary  to  obtain  maximum  benefits in terms of both harvestable product and ecosystem services.  This will be done combining modelling and experimental approaches, with a pilot site in the northern Adriatic sea. This approach will be included in the global environmental change scenario, and environmental optimals will be found where is possible to employ these strategies for maximum return in order to extend the theories beyond our study system.   The  results  of  this  project  will  benefit  mutiple  stakeholders,  from  fishermen  to  policy  to  scientists  working  in  similar  areas.  The outcomes  will  move  forward  the  concept  of  integrating  practices  to  obtain  greatest  sustainability  without  impeding  economical  advances.    I  aim  to  publish  results  in  the  form  of  scientific  peer  review  articles and as a tool box guideline for best practices.
On the Parameterized Complexity of the Maximum Edge 2-Coloring Problem

We investigate the parameterized complexity of the following edge coloring problem motivated by the problem of channel assignment in wireless networks. For an integer q ≥ 2 and a graph G, the goal is to find a coloring of the edges of G with the maximum number of colors such that every vertex of the graph sees at most q colors. This problem is NP-hard for q ≥ 2, and has been well-studied from the point of view of approximation. Our main focus is the case when q = 2, which is already theoretically intricate and practically relevant. We show fixed-parameter tractable algorithms for both the standard and the dual parameter, and for the latter problem, the result is based on a linear vertex kernel.
Subvención de capital de trabajo para Smart Service Adrian Szałapski

El proyecto tiene como objetivo apoyar a la empresa en la provisión de liquidez y apoyar sus operaciones diarias debido a las dificultades financieras que se produjeron en la empresa como resultado del brote de COVID-19. Ayuda financiera concedida sobre la base del régimen n.º SA.57015
$$\beta $$ β -skeletons for a Set of Line Segments in $$R^2 $$ R 2

\(\beta \)-skeletons are well-known neighborhood graphs for a set of points. We extend this notion to sets of line segments in the Euclidean plane and present algorithms computing such skeletons for the entire range of \(\beta \) values. The main reason of such extension is the possibility to study \(\beta \)-skeletons for points moving along given line segments. We show that relations between \(\beta \)-skeletons for \(\beta > 1\), 1-skeleton (Gabriel Graph), and the Delaunay triangulation for sets of points hold also for sets of segments. We present algorithms for computing circle-based and lune-based \(\beta \)-skeletons. We describe an algorithm that for \(\beta \ge 1\) computes the \(\beta \)-skeleton for a set S of n segments in the Euclidean plane in \(O(n^2 \alpha (n) \log n)\) time in the circle-based case and in \(O(n^2 \lambda _4(n))\) in the lune-based one, where the construction relies on the Delaunay triangulation for S, \(\alpha \) is a functional inverse of Ackermann function and \(\lambda _4(n)\) denotes the maximum possible length of a (n, 4) Davenport-Schinzel sequence. When \(0 < \beta < 1\), the \(\beta \)-skeleton can be constructed in a \(O(n^3 \lambda _4(n))\) time. In the special case of \(\beta = 1\), which is a generalization of Gabriel Graph, the construction can be carried out in a \(O(n \log n)\) time.
DRILLING TOOL

The invention relates to a drilling tool (10), in particular a rock drill, which extends along a longitudinal axis and comprises a drill head (24), an insertion end (16), a main body (32), a cover element (34), and a transport region (22) which is located between the drill head and the insertion end, and at least one transport channel (36) which extends along the transport region, said transport channel being located radially between the cover element and the main body. According to the invention, the cover element (34) comprises at least one interior region, which is located inside the main body, and at least one exterior region which is located outside the main body.
Searching for the 1912 Maymyo earthquake: New evidence from paleoseismic investigations along the Kyaukkyan Fault, Myanmar

Abstract The Great Burma earthquake (MsGR 8.0; Ms 7.6–7.7) occurred on May 23rd, 1912, and was one of the most remarkable early 1900's seismic events in Asia as described by Gutenberg and Richter (1954). The earthquake, focused near Maymyo, struck the Northern Shan State in eastern Myanmar. Contemporary evaluation of damage distribution and oral accounts led to a correlation between the earthquake and the topographically prominent Kyaukkyan Fault near the western margin of the Shan Plateau, although direct evidence has never been reported. This study aims to find evidence of paleoseismic activity, and to better understand the relationship between the 1912 earthquake and the Kyaukkyan Fault. Paleoseismic trenching along the Kyaukkyan Fault revealed evidence of several surface rupturing events. The northernmost trench exposes at least two visible rupture events since 4660 ± 30 BP: an older rupture stratigraphically constrained by AMS 14C dating to between 4660 ± 30 BP and 1270 ± 30 BP, and a younger rupture formed after 1270 ± 30 BP. The presence of pottery, bricks and cooking-related charcoal in the younger faulted stratigraphy demonstrates Kyaukkyan Fault activity within human times, and a possible correlation between the younger rupture and the 1912 Maymyo earthquake is not excluded. The southern paleoseismic trench, within a broad transtensional basin far from bounding faults, exposes two (undated) surface ruptures. Further study is required to correlate those ruptures to the events dated in the north. These preliminary paleoseismological results constitute the first quantitative evidence of paleoseismic activity along the northern ~160 km of the Kyaukkyan Fault, and support existing evidence that the Kyaukkyan Fault is an active but slow-slipping structure with a long interseismic period.
Transmission management for congested power system: A review of concepts, technical challenges and development of a new methodology

Transmission networks have some constraints that should be addressed in order to ensure sufficient control to maintain the security level of a power system while maximising market efficiency. The most obvious drawback of transmission constraints is a congestion problem that becomes an obstacle to perfect competition among the market participants since it can influence spot market pricing. As the power flow violates transmission constraints, redispatching generating units is required and this will cause the price at every node to vary. This manuscript presents concepts, technical challenges and methodology for investigating an alternative solution to the redispatch mechanism and then formulates LMP scheme using an optimisation technique that may well control congestion as the main issue. The LMP scheme are varied and improved to take into account the energy price, congestion revenue, cost of losses, as well as the transmission usage tariff by utilising shift factor-based optimal power flow (SF-OPF), which is derived from the well-known DC optimal power flow (DC-OPF) model.
Allergic multimorbidity from birth to young adulthood: determinants, epigenetic regulation  and inflammatory processes

The prevalence of allergic diseases, such as atopic eczema, asthma and rhinitis, has increased over the past decades and is currently estimated to be up to 40%. Prevention strategies play a pivotal role, as there are no curative treatments available. Therefore, the aim of ALLERGENE is to understand the complex interplay of genetic, environmental and lifestyle factors and to identify involved mechanisms that distinguish between young adults free of allergic diseases and those suffering from allergic multimorbidity.  Therefore, the aims of the present project are to:  1. Define allergic disease trajectories from birth to young adulthood, describe their determinants and identify risk and protective early-life environmental and lifestyle factors contributing to progression towards allergic multimorbidity or remission of allergic diseases. 2. Investigate molecular mechanisms of epigenetic regulation of allergic disease trajectories and test effect modification by inclusion of selected environmental and lifestyle factors. 3. Characterise the underlying inflammation profile of allergic disease trajectories and determine interactions with environmental and lifestyle factors  The project makes use of two long-standing, prospective German birth cohort studies, GINIplus and LISA, with available data from birth to young adulthood, and an extensive examination planned at age 25. Within this project, a comprehensive characterisation of allergic disease trajectories, their determinants, comorbidities, risk and protective factors across the life-course will be obtained. ALLERGENE will enhance the understanding of how modifiable factors contribute to allergic disease aetiology. This will be an essential prerequisite to develop effective early intervention strategies for susceptible populations and to identify disease-specific biomarkers for the development and progression of allergic diseases in the future.
Families matter: Social relationships and adolescent HIV testing behaviors in Ndola, Zambia

A cross-sectional survey among 550 randomly selected 16–19-year-olds in Ndola, Zambia, assessed the influence of individual (e.g., HIV knowledge), relational (e.g., discussed HIV testing with family), and environmental factors (e.g., distance) on adolescents’ use of HIV counseling and testing. A multivariable logistic regression analysis comparing respondents who have taken an HIV test to respondents who have not found that at the relational level believing that one’s family would not be upset if the youth has taken an HIV test (adjusted odds ratio [AOR] = 5.08; 95% confidence interval [CI] = 1.16–22.35); and having discussed with a family member whether or not to take an HIV test (AOR = 3.51; 95% CI = 1.08–11.47) were significantly related to adolescent testing. At the individual-level, having ever had sex (AOR = 6.43; 95% CI = 2.14–19.30) and being out-of-school (AOR = 2.95; 95% CI = 1.32–6.59) were also strongly associated with HIV testing. Environmental measures were not found to be significantly rela...
Disruptive fluorescent technologies for inflammatory bowel diseases

Inflammatory bowel diseases (IBD) are chronic immune-mediated disorders causing inflammation of the gastrointestinal tract, which affect around 3 million patients in the EU. Current monitoring of IBD is mainly performed in the form of colonoscopies, biopsies or tests which are invasive or cannot specifically report on IBD activity. There is a need for new technologies that can rapidly measure activity biomarkers of IBD and enable the monitoring of disease progression and response to therapy accurately. This unmet patient need is what drives the development of this ERC PoC project.

The ERC CoG DYNAFLUORS (Dynamic Activatable Fluorophores) project was funded to develop the first chemical toolbox for imaging the activity of immune cells in real time. In IBD, the activity of immune cells are important indicators of the disease state and can be used to assess how patients respond to therapy. DYNAFLUORS measure real-time immune cell activity; hence they are optimal tools to monitor disease progression in IBD patients facilitating a more accurate and personalised therapeutic approach. Based on our promising results in the ERC CoG, we aim to develop DYNAFLUORS into a new fluorescent technology for imaging IBD activity which will lead to: 1) new tools for IBD research and drug discovery in collaboration with companies covering the global fluorescent reagent market as well as Pharma, and 2) point-of-care technologies for clinical diagnostics in IBD patients.

Funding from the ERC PoC will allow us to commercialise fluorescent reagents for research, in vitro diagnostics and drug discovery as well as to establish the foundations for new translational technologies to measure IBD activity in patients. This project will be guided by input from existing and new industrial and clinical partners and will create numerous opportunities for accelerating the research, diagnosis and treatment of IBD.
Polyol blends useful for producing viscoelastic foam

A polyol composition is made by polymerizing a mixture of ethylene oxide and propylene oxide onto a mixture of at least one diol initiator and at least one triol initiator, followed by polymerizing 100% propylene oxide or a mixture of at least 90 weight percent propylene oxide and at most 10 weight percent ethylene oxide. The resulting polyol composition has a hydroxyl equivalent weight of 200 to 400 and an average nominal functionality of 2.05 to 2.95 hydroxyl groups/molecule. 5 to 30 percent of the hydroxyl groups of the coinitiated polyether polyol are primary hydroxyl groups and polymerized ethylene oxide constitutes 40 to 63 percent of the total weight of the coinitiated polyether polyol.
Heavy metal accumulation and tolerance of energy grass (Elymus elongatus subsp. ponticus cv. Szarvasi-1) grown in hydroponic culture

Phytoremediation is a plant based, cost effective technology to detoxify or stabilise contaminated soils. Fast growing, high biomass, perennial plants may be used not only in phytoremediation but also in energy production. Szarvasi-1 energy grass (Elymus elongatus subsp. ponticus cv. Szarvasi-1), a good candidate for this combined application, was grown in nutrient solution in order to assess its Cd, Cu, Ni, Pb and Zn accumulation and tolerance. Its shoot metal accumulation showed the order Pb < Ni < Cu ∼ Cd < Zn. In parallel with this, Pb and Ni had no or very little influence on the growth, dry matter content, chlorophyll concentration and transpiration of the plants. Cu and Cd treatment resulted in significant decreases in all these parameters that can be attributed to Fe plaque formation in the roots suggested by markedly increased Fe and Cu accumulation. This came together with decreased shoot and root Mn concentrations in both treatments while shoot Cu and Zn concentrations decreased under Cd and Cu exposure, respectively. Zn treatment had no effect or even slightly stimulated the plants. This may be due to a slight stimulation of Fe translocation and a very efficient detoxification mechanism. Based on the average 300 mg kg⁻¹ (dry mass) Zn concentration which is 0.03% of the shoot dry mass the variety is suggested to be classified as Zn accumulator.
Plugplay gasification plant for onsite conversion of otherwise unusable waste into renewable energy

Typical gasification processes’ design, control and capital investment make it profitable only for medium-large scale with important throughput (plant > 1 GWh per year of electricity, with investment costs > 1M€). This falls well beyond the needs of the medium standard industrial consumption band, with annual electricity consumption between 500 and 2,000 MWh, i.e 3-4 orders of magnitude lower.
 
Hysytech is positioned at this market gap. Synergy technology represents a novel  turn-key product for the conversion of by-products from industry into fuel gas (syngas) through gasification. Synergy can be easily adapted as part of the production process of industrial manufacturing plants, with a treatment capacity of 100 kg per hour, generating 800 MWh per year of electricity and 600 MWh of useful heat.
 
One of the biggest advantages of Synergy is making gasification affordable and profitable for small volume plants to be installed at manufacturing sites without the need of modifying the usual process or hiring new specialised operators. The selling price of Synergy gasification plant is estimated at €400 k including the installation of a fully ready-to-operate plant. This makes gasification an affordable and profitable investment for a medium industrial site, with a payback period of 2 to 5 years.
 
This new technology has been developed after a preliminary assessment of some business opportunities on the field. The result is an existing prototype plant (processing 10kg/h) with the improved design of the complete plant, including the fluid bed reactor and gas clean-up system.
 
Funded in 2003, Hysytech is today a pioneer in the field of process engineering and, in particular, in the design and construction of turn-key plants for fuel chemical processing, energy production and environmental treatment with its processes installed in more than 450 industrial sites. The Synergy project is a natural continuation of its experience and capability.
Fostering Interfaith Dialogue and Enhancing Cross-border Religious Tourism

Less than a year ago, with a joint statement, the religious communities in Albania – Catholic, Orthodox, Muslim, Evangelical, Bektashis – voiced their support to the Country’s EU accession. Freedom of religion and belief, together with the enhancement of cultural dialogue, is a long-standing priority of the European Union. As recently confirmed by the EU delegation in Geneva, the EU remains fully committed to advancing the Istanbul Process. On the other side of the Adriatic, Puglia always had as a radical, almost ancestral bond with inter-religious experiences, testified by its history, traditions and cultural sites.

As a whole, the Southern Adriatic area stands as a unique example of religious coexistence, interfaith dialogue, multicultural values, fascination for diversity and cross-contamination, with a great asset of inter-religious architectures, experiences, and events. However, the touristic appeal of the area is much less structured than in other places of inter-religious tourism, such as Jerusalem, Cordoba, Beirut, Sarajevo, Istanbul, Palermo, Kazan.

INTERFIDE-CRT is the first structured attempt to develop an operative framework for the enhancement of the touristic potential of inter-religious experiences in Albania, Italy, and Montenegro, supporting valuable cooperation between sector stakeholders and religious authorities. Thanks to a multi-actor approach, the project will have tangible outcomes under the economic standpoint, together with an enhancement of the European core values of tolerance, dialogue, and inclusion.

The action includes the InterFide Lab, working with innovative techniques and impact indicators; the InterFide Network, which will sustain and foster institutional relations with public, private and religious authorities; the INTERFIDE-CRT, a cross-border, statistically representative pilot itinerary together with a set of targeted infrastructural investments.
Ready Access to Illicit Drugs among Youth and Adult Users

Background: Current drug-control strategies in Canada focus funding and resources predominantly on drug law enforcement, often at the expense of preventive, treatment, and harm reduction efforts. This study aimed to examine the availability of the most commonly used substances in Vancouver, Canada after the implementation of such strategies. Methods: Using data from two large cohorts of drug-using youth and adults in Vancouver from the calendar year 2007, we assessed perceived availability of heroin, crack, cocaine, crystal methamphetamine, and marijuana. Results: Compared to youth (n= 330), a greater proportion of adults (n= 1,160) reported immediate access (ie, within 10 minutes) to heroin (81.0% vs. 55.9%, p < .001), crack (90.4% vs. 69.3%, p < .001), and cocaine (83.7% vs. 61.1%, p < .001). Conversely, larger proportions of youth reported immediate access to crystal methamphetamine (62.8% vs. 39.4%, p < .001) and marijuana (88.4% vs. 73.2%, p < .001) compared to adult users. Conclusions: Regardless of differences in illicit drug availability by age, all drugs are readily accessed in Vancouver despite drug law enforcement efforts. This includes drugs that are frequently injected and place users at risk of human immunodeficiency virus (HIV) infection and transmission of other blood-borne disease. (Am J Addict 2012;00: 1–3)
Development of the company through the implementation of an innovative technology for the production of circular and non-circular profiles by cold-forming of strips or sheets and longitudinal bonding.

The project involves the implementation of product, process and non-technological innovation. The characterised technology concerns the implementation of the production process of steel profiles with wheeled and non-circular cross-sections to make an innovative product in the form of advanced elements of the frame of vehicle seats for the automotive industry.