SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Stability Study of Mg and Al Doped and Co Doped ZnO Hydrides by Ab Initio Calculations

Electronic structure of ZnO:H
 i
 , (Zn,Mg)O:H
 i
 , (Zn,Al)O:H
 i
 , and (Zn,(Al,Mg))O:H
 i
 materials with hydrogen in interstitial sites are calculated versus Mg and Al doping content by using the Korringa–Kohn–Rostoker (KKR) method combined with Coherent Potential Approximation (CPA). Formation energy and decomposition temperature are evaluated as well and discussed in terms of the stability and hydrogen storage capacity of (Zn,Mg)O. In addition, detailed information about total and partial density of states (DOS) are highlighted and hybridization between atoms in ZnO:H
 i
 , (Zn,Mg)O:H
 i
 , and (Zn,(Al,Mg))O:H
 i
 is investigated. Here, the reduction of ZnO:H
 i
 and (Zn,Al)O:H
 i
 stability by the alloying of Mg element is asserted by the electronic structure analysis.
The effect of anti-VEGF drugs (bevacizumab and aflibercept) on the survival of patients with metastatic colorectal cancer (mCRC)

Significant progression has been achieved in the treatment of metastatic colorectal cancer (mCRC) in recent years. This has been partly attributed to successfully incorporating new drugs into combination chemotherapy. In addition to the traditional cytotoxic chemotherapeutic agents, molecularly targeted agents began to play an important role in the treatment of advanced solid tumors. To date, two classes of molecularly targeted agents have been approved for treatment of patients with mCRC: (1) antivascular endothelial growth factor (anti-VEGF) agents (such as bevacizumab and aflibercept) and (2) antiendothelial cell growth factor receptor (anti-EGFR) agents (such as cetuximab and panitumumab). Aflibercept is a new member of anti-VEGF agents which has demonstrated efficacy for treatment of mCRC. With the commencement of clinical trials and basic research into aflibercept, more data from the bedside and the bench have been obtained. This review will outline the application of anti-VEGF agents by reviewing clinic experiences of bevacizumab and aflibercept, and try to add perspectives on the use of anti-VEGF agents in mCRC.
A coincidence of HLA-B27 negative spondyloarthritis and paravertebral non-Hodgkin's lymphoma--a lesson to be learnt from the past experience.

We reported a case of a 71-year-old woman with progressive low back pain and neurologic symptoms of lower extremities, who in the background had the coexistence of spondyloarthritis (SpA) and non Hodgkin's lymphoma of the paravertebral location. This example describes a situation where SpA with minimal sacroiliac joints affection has nevertheless led to the overt axial SpA. This situation included undifferentiated or reactive SpA, as well as unusual disease context, presented with late-life disease onset, older age, female gender and no obvious hereditary predisposition. This combination of comorbid factors could allow environmental and disease-specific factors to accumulate over time and to, by modifying the primary, low-penetrant genetic background, lead to the development of lymphoma. By achieving better understanding of disease pathophysiology dynamic, we will be able to improve our capabilities to navigate biologic therapy in the future, in order to prevent the development of both, overt SpA and lymphoproliferative disease.
Threod theia vertical take-off and landing uas: solving unmanned aircraft challenges at sea and elsewhere

Unmanned Aerial Systems can bring minimal risk and cost advantages to many civil and military applications when compared to manned vehicles. In most applications the aircraft has to take-off and land on limited space. That makes Vertical Take-off and Landing systems very useful, particularly for tasks on unstable ground or harsh environments.
Current unmanned solutions either require large mechanisms for take-off and recover, or, if they have vertical take-off and landing capability, they lack endurance and payload carrying capacity.
Threod is currently developing the hybrid multi-task Unmanned Aircraft System THEIA that is capable of combining Vertical Take-off and Landing with the most efficient fixed-wing flying mode. The aircraft has military-grade built, is highly efficient with 10 h flying capacity, can carry and release the heaviest payload on the market (20 kg), and transmit real-time imaging at 150 km distance, making it a unique solution in the market.
The market for Unmanned Aerial Systems is booming, particularly for civil applications. THEIA solution fills a market gap in that segment, mainly in maritime environment tasks. Not only Threod solution was designed to handle the maritime operations, there is the need for a solution to measure ship greenhouse gas emissions, so EMSA can enforce EU environmental legislation. The aircraft can also be used by national authorities/institutions in highly needed open sea and coastline surveillance, search and rescue, and delivery of humanitarian aid in harsh terrain.
Threod has a track record of €8 million in product sales over the last 3 years, and has gathered substantial interest by global unmanned aircraft service providers, in the areas of environmental monitoring and security. By 2022 Threod is aiming at €10 million in revenues, 50% coming from the new unmanned aircraft system.
The solution of target assignment problem in command and control decision-making behaviour simulation

C2 command and control has been understood to be a critical military component to meet an increasing demand for rapid information gathering and real-time decision-making in a dynamically changing battlefield environment. In this article, to improve a C2 behaviour model’s reusability and interoperability, a behaviour modelling framework was proposed to specify a C2 model’s internal modules and a set of interoperability interfaces based on the C-BML coalition battle management language. WTA weapon target assignment is a typical C2 autonomous decision-making behaviour modelling problem. Different from most WTA problem descriptions, here sensors were considered to be available resources of detection and the relationship constraints between weapons and sensors were also taken into account, which brought it much closer to actual application. A modified differential evolution MDE algorithm was developed to solve this high-dimension optimisation problem and obtained an optimal assignment plan with high efficiency. In case study, we built a simulation system to validate the proposed C2 modelling framework and interoperability interface specification. Also, a new optimisation solution was used to solve the WTA problem efficiently and successfully.
Is Outpatient Emergency Department Care Profitable? Hourly Contribution Margins by Insurance for Patients Discharged From an Emergency Department

We determine the contribution margin per hour (ie, profit) by facility evaluation and management (E&M) billing level and insurance type for patients treated and discharged from an urban, academic emergency department (ED).Billing and demographic data for patients treated and discharged from an ED with greater than 100,000 annual visits between 2003 and 2009 were collected from hospital databases. The primary outcome was contribution margin per patient per hour. Contribution margin by insurance type (excluding self-pay) was determined at the patient level by subtracting direct clinical costs from contractual revenue. Hospital overhead and physician expenses and revenue were not included.In 523,882 outpatient ED encounters, contribution margin per hour increased with increasingly higher facility billing level for patients with commercial insurance ($70 for E&M level 1 to $177 at E&M level 5) but decreased for patients with Medicare ($44 for E&M level 1 to $29 at E&M level 5) and Medicaid ($73 for E&M level 1 to -$16 at E&M level 5). During the study years, cost, charge, revenue, and length of stay increased for each billing level.In our hospital, contribution margin per hour in ED outpatient encounters varied significantly by insurance type and billing level; commercially insured patients were most profitable and Medicaid patients were least profitable. Contribution margin per hour for patients commercially insured increased with higher billing levels. In contrast, for Medicare and Medicaid patients, contribution margin per hour decreased with higher billing levels, indicating that publicly insured ED outpatients with higher acuity (billing level) are less profitable than similar, commercially insured patients.
INDUSTRIAL TOURIST ORGANISATIONS — SANREMO CAMPING O.I.T. S.R.L.

THE COMPANY O.I.T. SRL, MANAGES THE CURRENT CAMPING VILLAGE OF FLOWERS, REALITY OPERATING ON THE TOURIST MARKET IN SANREMO ALREADY 'SINCE 1957. FOR THE FIRST TIME IN ITS HISTORY, FOLLOWING THE COVID-19 EMERGENCY, THE TOURIST-RECEPTIVE STRUCTURE (ALWAYS OPEN THROUGHOUT THE YEAR) FOUND ITSELF IN A POSITION TO CLOSE. NEEDLESS TO STRESS THE HARD BLOW THAT HAS BROUGHT THE TOURISM SECTOR TO ITS KNEES AND OUR COMPANY, WHICH TODAY IS TRYING WITH ALL ITS STRENGTH TO RISE UP IN THE BEST WAY. THE CLASSIFICATION CARRIED OUT BY THE PROVINCE OF IMPERIA (ARTICLE 48(1) OF L.R. N.2 2008), CATALOGUES THAT TOURIST ACCOMMODATION IN THE OPEN AIR AS A REALITY OF EXCELLENCE AS A 4-STAR CAMPSITE. FOR THE OVERNIGHT STAY OF THE CUSTOMERS IT USES ABOUT 100 PITCHES ‘TYPE CAMPEGGIO’ AND ABOUT 100 PITCHES ‘TOURIST VILLAGE TYPE’, FOR A TOTAL OF MORE THAN 900 BEDS. THE TOTAL ANNUAL PRESENCE SEES A
Exact relaxation for the semidefinite matrix rank minimization problem with extended Lyapunov equation constraint

The semidefinite matrix rank minimization, which has a broad range of applications in system control, statistics, network localization, econometrics and so on, is computationally NPhard in general due to the noncontinuous and non-convex rank function. A natural way to handle this type of problems is to substitute the rank function into some tractable surrogates, most popular ones of which include the convex trace norm and the non-convex Schatten p-norm relaxations with p ∈ (0, 1). The corresponding exactness of these relaxations have absorbed great attention and interest from researchers both in mathematics and engineering fields. In this paper, a special semidefinite matrix rank minimization problem with the extended Lyapunov equation constraint arising from low-order optimal control is considered and shown to possess the desired exact relaxation properties by exploiting the special structures of the involved linear transformation and by developing some essential properties and features on rank function and the semidefinite matrix cone.
NIPA2 located in 15q11.2 is mutated in patients with childhood absence epilepsy

While pathogenic copy number variations (CNVs) in 15q11.2 were recently identified in Caucasian patients with idiopathic generalized epilepsies (IGEs), the epilepsy-associated gene(s) in this region is/are still unknown. Our study investigated whether the CNVs in 15q11.2 are associated with childhood absence epilepsy (CAE) in Chinese patients and whether the selective magnesium transporter NIPA2 gene affected by 15q11.2 microdeletions is a susceptive gene for CAE. We assessed IGE-related CNVs by Affymetrix SNP 5.0 microarrays in 198 patients with CAE and 198 controls from northern China, and verified the identified CNVs by high-density oligonucleotide-based CGH microarrays. The coding region and exon-intron boundaries of NIPA2 were sequenced in all 380 patients with CAE and 400 controls. 15q11.2 microdeletions were detected in 3 of 198 (1.5%) patients and in no controls. Furthermore, we identified point mutations or indel in a heterozygous state of the NIPA2 gene in 3 out of 380 patients, whereas they were absent in 700 controls (P = 0.043). These mutations included two novel missense mutations (c.532A>T, p.I178F; c.731A>G, p.N244S) and one small novel insertion (c.1002_1003insGAT, p.N334_335EinsD). No NIPA2 mutation was found in 400 normal controls. We first identified that NIPA2, encoding a selective magnesium transporter, is a susceptible gene of CAE, and 15q11.2 microdeletions are important pathogenic CNVs for CAE with higher frequency in Chinese populations than that previously reported in Caucasians. The haploinsufficiency of NIPA2 may be a mechanism underlying the neurological phenotypes of 15q11.2 microdeletions.
Learning with transductive SVM for semisupervised pixel classification of remote sensing imagery

Abstract Land cover classification using remotely sensed data requires robust classification methods for the accurate mapping of complex land cover area of different categories. In this regard, support vector machines (SVMs) have recently received increasing attention. However, small number of training samples remains a bottleneck to design suitable supervised classifiers. On the other hand, adequate number of unlabeled data is available in remote sensing images which can be employed as additional source of information about margins. To fully leverage all of the precious unlabeled data, integration of filtering in a transductive SVM is proposed. Using two labeled image datasets of small size and two large unlabeled image datasets, the effectiveness of the proposed method is explored. Experimental results show that the proposed technique achieves average overall accuracies of around 4.5–7.8%, 0.8–2.6% and 0.9–2.2% more than the standard inductive SVM (ISVM), progressive transductive SVM (PTSVM) and low density separation (LDS) classifiers, respectively on larger domains in case of labeled datasets. Using image datasets, visual interpretation from the classified images as well as the segmentation quality reveal that the proposed method can efficiently filter informative data from the unlabeled samples.
Layered Clay-Alginate Composites for the Adsorption of Anionic Dyes: A Biocompatible Solution for Water/Wastewater Treatment

Adsorption properties of layered anionic clay-composites for the removal of anionic dyes from water were studied. The dye adsorption capacities of the composites were higher than the pristine clay. The clay-alginate composite with 5.9% alginate showed highest adsorption for both the dyes. The maximum adsorption capacity of the composite was enhanced by 51% for Acid Green 25 and 160% for Acid Green 27, compared to the pristine layered clay sample. The adsorption isotherm data were fitted to the Langmuir, Freundlich and Temkin isotherm models. The isotherm data could be explained well using the Freundlich isotherm model. Adsorption kinetics was analyzed using normal first order and Lagergren first order kinetic models.
Egnos-Gps/Galileo-Based high-resolution terrestrial-aerial sensing system.

The first objective is to build a mature prototype of a novel tandem terrestrial-aerial mapping system based on a terrestrial vehicle (TV) and on an unmanned aircraft (UA), both equipped with remote sensing payloads. The UA will follow the TV at a constant flying height above ground while geodata are acquired simultaneously from the TV and the UA. The final product is high resolution, oriented, calibrated and integrated images of a corridor and its environment.
The second objective is to demonstrate services; i.e., the technical/commercial feasibility of the concept.
The third objective is to develop the market: at the end of the project, contracts or negotiations shall be in place so the prototype can be used in operational conditions.
MapKITE targets corridor mapping. It is a terrestrial-aerial surveying system that combines the advantages of the terrestrial and airborne (manned or unmanned) ones.  It responds to corridor mapping market needs only fulfilled by much more expensive separate terrestrial and aerial missions.
An enabling component is the navigation payload based on EGNOS and the E5 AltBOC Galileo signal, superior to existing/planned GPS signals and of particular interest for robustness/integrity.
An octocopter of UAVision will be modified and equipped with the avoidance collision system of CATUAV.
Due to the low weight of the UA (less than 5 kg), to its low flying altitude (range between 30 m and maximum allowed height) and to its inbuilt line of sight [TV to UA] keeping feature, mapKITE does not suffer from the regulations affecting UAS civilian use. Its design is dominated by safety and abidance to current and foreseeable rules for small UA. Unrestricted testing will be conducted in a segregated airspace area that has been recently awarded by the Spanish aviation authorities.
MapKITE is highly innovative: new surveying paradigms, new mathematical models, new ways of fusing sensors and a new “map” product. It is protected by the Spanish patent 2012312
Precision medicine with induced pluripotent stem cells for cardiac arrhythmias risk evaluation

Long QT Syndrome (LQTS) is a severe arrhythmogenic condition characterised by the prolongation of the QT interval on the electrocardiogram. It is caused by genetic factors (congenital) or drugs (acquired) and sudden cardiac death can be the first manifestations of the disease. 
Advancements in genetic screenings have revealed profound links between genotype and phenotype for LQTS, improving diagnosis, risk stratification and therapy; 
However, it is still poorly understood why patients with identical pathogenic mutations have different clinical phenotypes, which factors are involved in this unpredictable disease severity and how we can protect these subjects from drug treatments that are safe in the general population.
We do need improved and more physiological in vitro models to simulate arrhythmias in vitro, effective for drug testing, to identify, evaluate and study factors that shape the arrhythmogenic risk in vulnerable subjects.
Here I propose a precision medicine approach that uses human pluripotent stem cells-derived cardiomyocytes (hPSC-CMs) from LQTS families (rare resources that include male, female, symptomatic and asymptomatic patients) to: 
i) demonstrate that the hiPSC technology can reproduce in vitro the clinical disease severity observed in symptomatic vs asymptomatic LQTS mutation carriers; 
ii) create an in vitro interdisciplinary pharmacological approach with proarrhythmic drugs which combines matched electrophysiological, contractile, molecular and genetic assays; 
iii) identify and evaluate the factors affecting the arrhythmogenic risk in predisposed subjects.
This pipeline to assess arrhythmia susceptibility from patient-specific hiPSC-CMs can be applicable to other arrhythmogenic syndromes. The results of this project will contribute to reduce the use of animal models in preclinical research, to create safer, more effective drugs for humans and to promote the shift of new therapeutic approaches towards precision or personalised medicine.
Travel Demand Management (TDM) case study for social behavioral change towards sustainable urban transportation in Istanbul

Abstract In order to realize sustainable cities, it is vital to achieve and maintain social behavioral change for shifting our modes of mobility from inefficient, wasteful and motorized means to cleaner, greener, healthier and more economic means such as walking, cycling and public transportation in addition to smart use of land, intelligent transportation systems, and clean and green vehicles. This study is based on a critical review of literature in order to establish a framework of social behavioral change policies, particularly developed and tested for urban mobility and traffic congestion. First, various mega cities were compared on different sustainability indicators to better understand the case of Istanbul. Then, selected policy potentials, namely Travel Demand Management (TDM), were evaluated for Istanbul following a set of personal interview surveys aiming to reveal travel patterns of residents, their perceptions and attitudes on current transport system performance, and their opinions for possible TDM interventions in the future. We proposed a multiplicative model to process data from these surveys as inputs, which would then be used to determine travel demand. A simulation model was constructed using PTV-VISSIM tool and validated with current traffic congestion metrics obtained from field measurements in a selected district of Istanbul. Based on this validated simulation model, projections of traffic conditions in the future under different TDM scenarios were predicted with the help of determined TDM potentials obtained from the survey results. As a result of this study, it was revealed that the traffic congestion levels in Istanbul tend to become worse year by year under existing conditions, but it was also found that the TDM policies offer significant potential for reducing congestion, hence its consequent hazards, via increased use of sustainable mobility modes without the need for new infrastructure investments.
The ISOLDE Facility

The ISOLDE facility [1–3] is one of the world-leading laboratories for the production and investigation of radioactive nuclei. ISOLDE belongs to CERN's accelerator complex situated on the border between Switzerland and France (Figure 1). The facility has been in operation since its start in 1967 and is presently receiving protons from the Proton Synchrotron Booster (PSB) of CERN. The success of ISOLDE is due to the continuous development of new radioactive ion beams and improvement of the experimental conditions. With the upcoming high energy and intensity upgrade HIE-ISOLDE the possibilities for experiments with exotic nuclei will be further boosted. This laboratory portrait gives an overview of the present facility that will focus on the status of radioactive ion beam production, the operation of ISOLDE, and the main experimental equipment rather than aiming at a comprehensive summary of physics results.
Product line development of innovative cutting tools with interchangeable carbide plates for grooving and cutting with unique geometry along with their manufacturing technology

R & D project to develop innovative worldwide cutting tools with carbide plates for grooving/cutting metals and their alloys with unique geometry along with their manufacturing technology. New tools thanks to the use of proprietary material and process recipes for 4 species of carbide spiek.and 4 grade PVD coatings will guarantee the highest (world) innovation/competitiveness in the tool industry for the dynamically developing mechanical processing industry (including the machinery, motor and aerospace industries). As part of the project, new knowledge will be created with the development of a unique: —the material combination of tools -geometrical concept of tools -concepts of PVD coatings for tool cutting plates -the method of combining tiles with a frame ensuring over-standard stability of the tool during processing using the highest cutting parameters.The new products will be based on the long-term experience of POLCOMM for the development of innovative machining tools (also in cooperation with one.s. research, i.e. Institute of Advanced Manufacturing Technologies, Polit.Rzeszowska, Polit.Warsaw) gained in several dozen ways of B+R. Urz. EU L 187/1 of 26.06.2014.
Architecture et design national autour du monde

Le projet présenté vise à l’internationalisation de la société APCM, Arquitetos ET ASSOCIADOS, LDA, en promouvant sa fourniture de services de haute qualité dans le domaine de l’architecture et de la conception, ces services, qui donneront à l’entreprise la notoriété et la diffusion, qu’elle entend réaliser.