SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
University-industry linkage evolution: an empirical investigation of relational success factors

University–industry linkages (UILs) offer an array of benefits for the parties involved and the economy at large; however, research provides limited theoretical development and practical advice on successfully managing UILs from initial negotiations to project completion and beyond. This paper, thus, empirically investigates the impact of relational success factors (communication, trust, understanding, individuals) on UIL performance across three phases of evolution, accounting for the changing manifestations of these factors over time. Communication emerged as a consistent predictor of success, with positive interrelationships between individuals advancing all relational success factors across all phases. A positive effect of trust and understanding, however, only emerged for some relationship phases. Results provide managers with insight into forms relational drivers take throughout long-lasting successful UILs.
Building Online Transaction Trust through a Two-Step Flow of Information Communication

AbstractE-commerce businesses have endeavored to facilitate online transactions by establishing website reputations through use of digital security mechanisms to alleviate the uncertainty about online transactions. This study incorporates the two-step flow of communication theory to elaborate on the antecedents that underlie consumers' intention to purchase online. Using data collected from 457 online shoppers in Taiwan, the findings suggest that third party issued e-certification and consumers' previous experience significantly influence party trust. In addition, party-trust significantly impacts online purchase intention. These results provide a clearer understanding of how to successfully build transaction trust and consequential behaviors. This paper concludes with several research implications.
Rna polymerase iii rpc4/rpc5 subcomplex and selenocysteine trna transcription

In higher eukaryotes, the RNA polymerase III (Pol III) participates in the transcription of small RNAs such as the tRNAs. RNA polymerase recruitment to their specific promoter relies on the activity of several transcription factors. Brf2 is a transcription factor that exclusively recruits RNA Pol III at the selenocysteine tRNA (tRNASec). Unpublished work from our group has unravelled an unanticipated central role of Brf2 in the oxidative stress response pathway, by acting as a cellular blockade during prolonged oxidative stress.
We are interested in understanding the molecular determinants that govern RNA Pol III recruitment at tRNASec promoter and its interaction with Brf2-bound promoters. In general, RNA Pol III subunit’s size is conserved amongst the eukaryotic kingdom. However, an exception is the human Rpc5 subunit, whose C terminus has 450 residues that are not present in its yeast counterpart C37. Similarly to Brf2, the Rpc5 C-terminal extension is only present in higher metazoans, which suggests a phylogenetic link between these two proteins. The recruiting mechanism of RNA Pol III to Brf2-dependent promoters has not been described to date. Preliminary results in our lab provide evidences that indeed Rpc5 C terminus is responsible for the accurate recruitment of RNA Pol III at TBP/Brf2/DNA complex. Interestingly, structural homology predictions indicated that the human Rpc5 C-terminal extension is a eukaryotic homologue of the prokaryotic protein SelB, a factor that interacts with the tRNASec and with a specific region of mRNAs, the SECIS-element, during translation of SeCys containing proteins. This similarity suggests a regulatory role for Rpc5 C terminus in the interaction with the SECIS-element and/or the tRNASec.
Our main objectives are to determine the structure of the Rpc5 C terminus in isolation and in complex with Brf2/TBP/DNA by X-ray crystallography and to characterise the role of Rpc5 C terminus in the context of tRNASec transcription.
Desarrollo de un sistema para la medición automatizada de parámetros de lente seleccionados

El objeto del proyecto es llevar a cabo trabajos de I+D que permitan el desarrollo de un sistema innovador para medir los parámetros de las lentes. El objetivo principal es aumentar el nivel de innovación y actividad de I+D inphotech. Esto se logrará logrando el objetivo específico, que se ha definido como el desarrollo y comercialización de un nuevo producto en forma de un sistema de medición de lentes. La funcionalidad principal del sistema será la medición del grosor de las lentes. El resultado del trabajo de I+D será una solución de mercado que caracteriza el nivel de innovación en el mercado global. La solución propuesta es innovadora a escala global y dará la posibilidad de medición sin contacto de parámetros de lente en muy poco tiempo y con la precisión requerida por la industria. Los resultados del proyecto son una respuesta a las tendencias del mercado destinadas a automatizar el proceso de medición, que no es proporcionado por ninguno de los dispositivos disponibles en el mercado. Esta es una propiedad extremadamente importante para las lentes producidas en masa (por ejemplo, lentes de contacto, gafas). Los resultados del proyecto se implementarán en las propias actividades de la Compañía. El proyecto está en línea con las direcciones de investigación prioritarias definidas para las 3 áreas de especialización inteligente del Voivodato Mazowieckie, las direcciones de investigación definidas en el mismo y al menos un objetivo de investigación dentro de una dirección determinada. El proyecto trata sobre la innovación de productos. Se ejecutará con apoyo financiero de la UE (con una contribución propia superior al mínimo requerido) mediante el apoyo a cuatro tareas del proyecto: el trabajo de investigación y desarrollo industrial realizado por el solicitante con la plena orientación de los usuarios finales.También está previsto crear pasantías y prácticas y cooperar con la unidad científica (UMCS) en virtud del acuerdo firmado.Aunque el proyecto está previsto para involucrar a la unidad científica-UMCS, todas las tareas serán llevadas a cabo por el solicitante utilizando el proyecto de infraestructura existente y previsto.
Calcium dysregulation in amyotrophic lateral sclerosis

In the fatal neurodegenerative disease amyotrophic lateral sclerosis (ALS), motor neurons degenerate with signs of organelle fragmentation, free radical damage, mitochondrial Ca2+ overload, impaired axonal transport and accumulation of proteins in intracellular inclusion bodies. Subgroups of motor neurons of the brainstem and the spinal cord expressing low amounts of Ca2+ buffering proteins are particularly vulnerable. In ALS, chronic excitotoxicity mediated by Ca2+-permeable AMPA type glutamate receptors seems to initiate a self-perpetuating process of intracellular Ca2+ dysregulation with consecutive endoplasmic reticulum Ca2+ depletion and mitochondrial Ca2+ overload. The only known effective treatment, riluzole, seems to reduce glutamatergic input. This review introduces the hypothesis of a "toxic shift of Ca2+" within the endoplasmic reticulum-mitochondria Ca2+ cycle (ERMCC) as a key mechanism in motor neuron degeneration, and discusses molecular targets which may be of interest for future ERMCC modulating neuroprotective therapies.
ANN based intelligent controller for inverted pendulum system

Artificial neural network as an artificial intelligence technique is used in this paper to control the angle with position of a non- linear inverted pendulum system. The ANN controller here is a specified three layered feed forward network having, Input, Hidden and Output layers. `Trainlm' network function that is used to update weights and bias states according to Levenberg- Marquardt (LM) back-propagation, is used here for training. The dynamic modelling of Inverted pendulum system is done using Euler-Langerange equation and the main task is to control the angle with position of non-linear system by the neural network controller and to compare the response with response of conventional controller using MATLAB simulations and to show the improved response.
Abstract 18727: RAGE-HMGB-1 Expression in the Ascending Aorta of Bicuspid Aortic Valve (BAV) Patients Correlates With Circulating SRAGE and May Predict Vascular Dysfunction Associated With BAV Disease

Introduction: Bicuspid Aortic Valve (BAV) is associated with premature valve and vascular complications. Thirty to 50% of BAV patients require surgery for valve diseases and/or ascending aorta (AA) dilatation. Increasing studies suggest that the measure of AA diameter, as criteria for aortic surgery, is an imperfect predictor of dissection and rupture. Therefore there is a need to identify reliable markers of dysfunctional AA to guide the decision for surgery. Recently, Advanced glycation end products (AGEs), such as HMGB-1 and S100A12, and their binding to the Receptor for AGE (RAGE) have been associated to mechanisms of valve and vascular degeneration. We previously demonstrated that BAV patients have higher plasma levels of the soluble form of RAGE (sRAGE) when compared with tricuspid aortic valve (TAV) patients. We also showed that the AA of BAV patients with higher circulating sRAGE is characterized by severe elastin degradation and matrix disorganization when compared to those with lower sRAGE. Hypothesis: We hypothesized that the level of circulating sRAGE may be related to the expression of AGEs and RAGE in the AA. Methods: HMGB-1 and S100A12 plasma values were measured by ELISA in BAV (N=20) and TAV (N=20) patients previously tested for sRAGE. Logistic regression and multivariate analysis were performed. AA tissue from BAV patients with sRAGE concentration ranging from 491 pg/mL to 5978 pg/mL were tested for the expression of RAGE, HMGB-1 and S100A12 by immunohistochemistry and Western blotting. Results: RAGE expression linearly increased in the AA of BAV patients with higher plasma sRAGE (R2=0.5). RAGE and sRAGE levels correlate with the expression of HMGB-1. S100A12 was minimally detected and restricted to inflammatory infiltrates in both BAV and TAV patients with AA dilatation. Plasma level of S100A12 and HMGB-1 were not significantly different in BAV patients when compared to TAV and did not correlate with sRAGE concentration. Conclusions: These results suggest that HMGB1-mediated RAGE activation in the AA of BAV patients may be responsible for tissue degeneration and increased sRAGE release in the bloodstream. The interaction AGE-RAGE in the AA of BAV patients may help in evaluating the risk for rapid AA degeneration independently of dilation.
Le sfumature del lusso a Bedriacum. Note su alcuni vetri preziosi di prima età imperiale dal Quartiere degli Artigiani

Questo articolo prende in considerazione alcuni reperti in vetro di notevole pregio, provenienti dal vicus romano di Bedriacum (attuale Calvatone, CR), scoperti durante le campagne di scavo svoltesi tra 2005 e 2013 nell’area del Quartiere degli Artigiani (scavi diretti dalla prof. Maria Teresa Grassi, Università degli Studi di Milano). I reperti analizzati si collocano cronologicamente tra la fine del I sec. a.C. e il pieno I sec. d.C., periodo che corrispose a una particolare fioritura del vicus stesso. Si è deciso pertanto di focalizzare l’attenzione su alcuni preziosi reperti ottenuti con la tecnica del vetro mosaico, della colatura e modellazione su forma capovolta (una coppa tipo Is.20, un unicum finora a Bedriacum, un fr. di coppa tipo Is.1/18 e due coppe costolate tipo Is.3), della soffiatura entro stampo (due frr. di coppe ispirate alla produzione di Ennione e un fr. di bicchiere troncoconico tipo Is.31) e tramite soffiatura libera (coppette costolate tipo Is.17 e frr. decorati a macchie).
La interpretación judicial en España en un momento de cambio

The publication in the European Union of Directive 2010/64/EU of the European Parliament and of the Council of 20 October 2010 on the right to interpretation and translation in criminal proceedings has been a turning point in a great number of aspects related to court and police interpretation. The main objective of the Directive is to ensure quality legal interpretation throughout the process, as part of the right to defence and to a fair trial. Spain, as a Member State of the EU, has the obligation to transpose this European Directive into its domestic law. Therefore, this is a historic moment in which two main factors converge: the need to change the legislation to bring it in line with the new Directive and the need to implement measures to ensure compliance with new mandates. This paper reviews the present state of legal interpretation in Spain from the point of view of legislation and that of service provision and analyses the measures that Spain should take to ensure that court and police interpretations are carried out with due guarantees. These measures include the training of interpreters and legal operators, the creation of accreditation systems and records, as well as the consolidation of the professional profile of interpreters.
Lymphit: an innovative easy-to-use and cost-efficient diagnostic microneedle patch for the early detection of lymphedema

Lymphedema is a chronic condition, outlined by a progressive accumulation of fluids in a limb, leading to great physical and psychological debilitation of the affected patient and often occurring secondary to oncologic treatments. There is not early diagnosis for lymphedema. Current diagnostic methods are highly inadequate and detect the disease only at an advanced stage, leading to serious complications, greatly decreasing quality-of-life of the patients while increasing healthcare costs. In response to this challenge, Dicronis has developed a diagnostic tool (LYMPHIT) based on a painless and minimally-invasive delivery of ICG, an FDA approved fluorescent agent, with an extremely high safety profile, integrated into polymeric dissolving microneedles patches which allows determining the status of the lymphatic system by optically measurement of the fluorescence decay. LYMPHIT enables patients and clinicians the earliest possible detection of lymphedema, by quantitatively tracking the function of the lymphatic system in a painless, easy-to-use and highly-scalable manner. LYMPHIT will be disrupting in the market by empowering medical practitioners to timely and selectively prescribe conservative treatments, which can contain or avoid a worsening of the swelling in the affected limb. Therefore, LYMPHIT will reduce lymphedema treatments costs up to 50% and reduce 10-fold the social costs associated to productivity loss, both of them associated with late stage lymphedema. Upon completion of the project, LYMPHIT will boost the growth of our company generating additional 64 FTEs, revenues of €398M and a ROI of 10.25 by the fifth year after Phase 2 execution. With the help of the SME instrument, Dicronis aims to complete the product optimization and clinical validation so that it can be commercialized across European markets first, and global markets later on, improving the quality of care of healthcare systems worldwide as well as the lymphedema patient´s quality of life.
Absorber Layer Addition and Thermal Storage Media Comparison for Concentrated Solar Power Plant Optimization

Abstract Electricity generation from concentrated solar power plant can be optimized on its storage system or its receiver system. This paper conducts a review of how to optimize the concentrated solar power plant by increasing the stored energy capacity or by stabilizing the absorptance and emittance in the solar absorber. The additional stages in the CSP may increase thermal efficiency. The stages consist of two oriented solar absorber to create superheated steam fed to the steam turbine and one regenerator to optimally regenerate heat for working fluid before pumped to solar absorber. A suitable treatment for superheated steam from solar absorber can optimally supply the turbine with a continually stable steam. The continuous stable steam can be controlled using steam accumulator right before the superheated steam fed into turbine. The thermal energy storage in the cycle can be optimally selected based on the stored energy capacity per kg of compared material used. The final modification was made using recently developed absorber material of hafnium molybdenum nitride to create four layer tandem absorber of HfMoN(H)/HfMoN(L)/HfON/Al2O3. The tandem absorber indicates a stable absorptance and emittance up until 600 °C (in vacuum) and 525 °C (in air). The final configuration believed to enhance the thermal stability for high temperature concentrated solar power plant application.
Benzophenanthridine alkaloid, piperonyl butoxide and (S)-methoprene action at the cannabinoid-1 receptor (CB1-receptor) pathway of mouse brain: Interference with [3H]CP55940 and [3H]SR141716A binding and modification of WIN55212-2-dependent inhibition of synaptosomal l-glutamate release

Abstract Benzophenanthridine alkaloids (chelerythrine and sanguinarine) inhibited binding of [ 3 H]SR141716A to mouse brain membranes (IC 50 s: 50 s: 21 and 63 µM respectively). Benzophenanthridines and piperonyl butoxide were more selective towards brain CB 1 receptors versus spleen CB 2 receptors. All compounds reduced B max of [ 3 H]SR141716A binding to CB 1 receptors, but only methoprene and piperonyl butoxide increased K d (3–5-fold). Benzophenanthridines increased the K d of [ 3 H]CP55940 binding (6-fold), but did not alter B max . (S)-methoprene increased the K d of [ 3 H]CP55940 binding (by almost 4-fold) and reduced B max by 60%. Piperonyl butoxide lowered the B max of [ 3 H]CP55940 binding by 50%, but did not influence K d . All compounds reduced [ 3 H]SR141716A and [ 3 H]CP55940 association with CB 1 receptors. Combined with a saturating concentration of SR141716A, only piperonyl butoxide and (S)-methoprene increased dissociation of [ 3 H]SR141716A above that of SR141716A alone. Only piperonyl butoxide increased dissociation of [ 3 H]CP55940 to a level greater than CP55940 alone. Binding results indicate predominantly allosteric components to the study compounds action. 4-Aminopyridine-(4-AP-) evoked release of l -glutamate from synaptosomes was partially inhibited by WIN55212-2, an effect completely neutralized by AM251, (S)-methoprene and piperonyl butoxide. With WIN55212-2 present, benzophenanthridines enhanced 4-AP-evoked l -glutamate release above 4-AP alone. Modulatory patterns of l -glutamate release (with WIN-55212-2 present) align with previous antagonist/inverse agonist profiling based on [ 35 S]GTPγS binding. Although these compounds exhibit lower potencies compared to many classical CB 1 receptor inhibitors, they may have potential to modify CB1-receptor-dependent behavioral/physiological outcomes in the whole animal.
The Glenn A. Fry Award Lecture 2012

Following the onset of central vision loss, most patients develop an eccentric retinal location outside the affected macular region, the preferred retinal locus (PRL), as their new reference for visual tasks. The first goal of this article is to present behavioral evidence showing the presence of experience-dependent plasticity in people with central vision loss. The evidence includes the presence of oculomotor re-referencing of fixational saccades to the PRL; the characteristics of the shape of the crowding zone (spatial region within which the presence of other objects affects the recognition of a target) at the PRL are more "foveal-like" instead of resembling those of the normal periphery; and the change in the shape of the crowding zone at a para-PRL location that includes a component referenced to the PRL. These findings suggest that there is a shift in the referencing locus of the oculomotor and the sensory visual system from the fovea to the PRL for people with central vision loss, implying that the visual system for these individuals is still plastic and can be modified through experiences. The second goal of the article is to demonstrate the feasibility of applying perceptual learning, which capitalizes on the presence of plasticity, as a tool to improve functional vision for people with central vision loss. Our finding that visual function could improve with perceptual learning presents an exciting possibility for the development of an alternative rehabilitative strategy for people with central vision loss.
Vetdinha Pet Kits:: Introduction to the global pet market through penetration into the Digital Economy

VETDINHA: Training for Internationalisation through Diagnosis and Definition of a Strategy for penetration and performance in the Digital Economy, in dematerialised communication channels, leading to the implementation of optimised e-commerce and digital marketing processes
Separating Morphologically Similar Pollen Types Using Basic Shape Features from Digital Images: A Preliminary Study

One of the many advantages offered by automated palynology systems is the ability to vastly increase the number of observations made on a particular sample or samples. This is of particular benefit when attempting to fully quantify the degree of variation within or between closely related pollen types. •An automated palynology system (Classifynder) has been used to further investigate the variation in pollen morphology between two New Zealand species of Myrtaceae (Leptospermum scoparium and Kunzea ericoides) that are of significance in the New Zealand honey industry. Seven geometric features extracted from automatically gathered digital images were used to characterize the range of shape and size of the two taxa, and to examine the extent of previously reported overlap in these variables. •Our results indicate a degree of overlap in all cases. The narrowest overlap was in measurements of maximum Feret diameter (MFD) in grains oriented in polar view. Multivariate statistical analysis using all seven factors provided the most robust discrimination between the two types. •Further work is required before this approach could be routinely applied to separating the two pollen types used in this study, most notably the development of comprehensive reference distributions for the types in question.
Investition in eine neue, komplett vernetzte, Fertigungsstraße

Investition in ein vollständig vernetztes Produktionssystem für die Möbelteilfertigung von der Platte bis zur fertig verpackten Palette.
Tidal variability of CO2 and CH4 emissions from the water column within a Rhizophora mangrove forest (New Caledonia)

We performed a preliminary study to quantify CO2 and CH4 emissions from the water column within a Rhizophora spp. mangrove forest. Mean CO2 and CH4 emissions during the studied period were 3.35±3.62mmolCm-2h-1 and 18.30±27.72μmolCm-2h-1, respectively. CO2 and CH4 emissions were highly variable and mainly driven by tides (flow/ebb, water column thickness, neap/spring). Indeed, an inverse relationship between the magnitude of the emissions and the thickness of the water column above the mangrove soil was observed. δ13CO2 values ranged from -26.88‰ to -8.6‰, suggesting a mixing between CO2-enriched pore waters and lagoon incoming waters. In addition, CO2 and CH4 emissions were significantly higher during ebb tides, mainly due to the progressive enrichment of the water column by diffusive fluxes as its residence time over the forest floor increased. Eventually, we observed higher CO2 and CH4 emissions during spring tides than during neap tides, combined to depleted δ13CO2 values, suggesting a higher contribution of soil-produced gases to the emissions. These higher emissions may result from higher renewable of the electron acceptor and enhanced exchange surface between the soil and the water column. This study shows that CO2 and CH4 emissions from the water column were not negligible and must be considered in future carbon budgets in mangroves.