SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Use of immunoglobulins in adults in a university hospital: a retrospective study.

New applications are always being developed for immunoglobulins; new recommendations are regularly published. We wished to know the indications used in a large hospital. A hundred and thirty-six adult patients were prescribed immunoglobulins from January to December 2008. Three preparations in intravenous immunoglobulins were available (one liquid, 2 freeze-dried). Fourteen charts were rejected for clerical errors. A hundred and twenty two charts were available for statistical study. Thirty-six patients were on immunoglobulins for antibody deficiency, 19 were followed in haematology for chronic lymphoid leukaemia or multiple myeloma, 19 were treated after lung transplantation, 17 had received a kidney transplant, 1 after heart transplantation: these indications were substitution. Twenty for Guillain Barré and chronic demyelinating polyneuropathy, 10 in immune thrombocytopenic purpura: this was for immunomodulation. Recommendations were followed by the prescribers; charts were reviewed in March and November 2009. Side-effects were rare. (0.6%) (1).
Evidence that non-linear elasticity contributes to the seismic coda

SUMMARY

Different factors might affect the propagation of seismic waves producing scattering, including heterogeneities and non-linear elasticity. A key difference between these two factors is the dependence of the strength of the scattered waves on the strength of the incident wave, being linear for the former and non-linear for the latter. A detailed study of the TIPTEQ data, where about a hundred explosions were recorded on 180 three-component stations in the distance range of approximately 0–100 km, shows that this dependence is non-linear. Data were analysed in the following way: (i) the envelope of bandpass filtered data between 10 and 40 Hz was obtained for a large number of stations from different distance ranges and charge sizes of shots, (ii) for these distances we modelled the envelope considering the non-linear elasticity. The shapes of the theoretical and observed envelopes were in general very similar. A scale factor for each case was obtained considering the best fit of its complete envelope and (iii) since this scale factor depends mainly on the size of the explosion, we computed the ratio (R) of the scale factor (sf) for different sizes of explosions at the same distance. Finally, varying the distance between 0 and 50 km and (iv) we computed the power (p) of the dependence of the ratio (R) on the ratio of the charge sizes []. For the complete data set we obtain a value of p= 2.5 ± 0.9, which is clearly greater than 1. This shows that non-linear elasticity is an important factor in the contribution to seismic wave scattering in the frequency range of 10–40 Hz.
Carrier for cure: tailored combination drug delivery solutions for oncology

Chemotherapy, often given in conjunction with other therapies is infamous for its off target associated side effects. Recent studies have shown that drugs combinations can act synergistically at certain ratios and are more effective and less toxic than single drug therapies. Despite promising in vitro results, combination drug therapy for Oncology has not been successfully translated to the clinic due to lack of efficient delivery systems that can maintain the desired synergistic drug concentrations in the body as each drug has a different pharmacokinetics and toxicity profile. The objective of this project is to develop a universal platform for simultaneous delivery of multiple drugs to specific cells in vivo using a protein cage that was developed in our laboratory for encapsulation of diverse cargoes.
PLURAL LAYER WOVEN ELECTRONIC TEXTILE, ARTICLE AND METHOD

A woven article having plural weave layers comprises a plurality of electrically insulating and/or electrically conductive yarn in the warp and a plurality of electrically insulating and/or electrically conductive yarn in the weft interwoven with the yarn in the warp. An electrical function is provided by one or more circuit carriers disposed in cavities in the plural layer woven article and/or one or more functional yarn in the warp and/or the weft, wherein the circuit carrier and/or functional yarn include an electrical contact for connecting to the electrically conductive yarn in the warp and/or weft.
Desarrollo de un innovador dispositivo Softlanding para aterrizaje suave sobre cargas de paracaídas (hasta 50 kg), lo que aumenta la seguridad de la descarga al entrar en contacto con el suelo

Number_reference_aid_programa: SA.41471(2015/X) Objetivo de la ayuda pública: Artículo 25 del Reglamento (CE) n.º 651/2014, de 17 de junio de 2014, por el que se declaran determinadas categorías de ayudas compatibles con el mercado interior en la aplicación de los artículos 107 y 108 del Tratado Eso es todo. EU L 187/1 de 26.6.2014). El objeto del proyecto es el desarrollo de un dispositivo innovador para el aterrizaje suave de cargas de paracaídas (hasta un peso de 50 kg), que se caracterizará por un mayor nivel de seguridad de la carga en contacto con el suelo (PRODUCTO EN EL ESTADIO MUNDIAL según el Manual de Oslo, edición III, 2005). El nuevo producto en forma de dispositivo Softlanding se distinguirá por las siguientes características en comparación con las soluciones de la competencia con un propósito similar: 1. Reducir la sobrecarga durante el aterrizaje a 0,5G al menos 18 veces para el sistema de cartón, es decir, la solución más utilizada en el patrón de carga; 2. Reducción de al menos el doble del tamaño del dosel de paracaídas, es decir, a 30 m² desde 83 m² en el caso de un sistema de cartón; 3. Reducción por diez veces del tiempo de preparación de la carga para la descarga, es decir, a 3 minutos a partir de 30 minutos para los sistemas de cartón y cohetes; 4. Reducción a una tasa mínima de caída sin precedentes en contacto con el suelo a menos de 1 m/s (sistema de tablero: 6-8 m/s, sistema de cohetes: 3,5 m/s). El dispositivo Softlanding permitirá el aterrizaje de cargas que no se han descargado hasta ahora o que se han caído ocasionalmente debido al mayor riesgo de daños o daños en el momento del contacto con el suelo. Al instalar un nuevo producto de paracaídas, será posible aterrizar dispositivos sensibles como kits antiaéreos/antitanque móviles, así como equipos médicos, optoelectrónicos, informáticos, logísticos, etc. El proyecto se ejecutará en cooperación con entidades comerciales (subcontratación). La aplicación se llevará a cabo en
Accessible resources for cultural heritage ecosystems

The popularisation of digitisation techniques has boosted the generation of digital cultural heritage assets in recent years. However, such techniques should not be regarded as an end in and of themselves, but as a means for enabling European citizens to engage with cultural heritage more closely and in different ways. 
ARCHES aims to create more inclusive cultural environments particularly for those with differences and difficulties associated with perception, memory, cognition and communication. It will achieve this through in-depth research analysis and the development of innovative applications, functionalities and experiences based on the reuse and redevelopment of the aforementioned digital resources.
Our participatory research methodology situates real user needs at the heart of an iterative design and implementation process, through their active involvement in 3 pilot exercises. This will also facilitate the validation of potential solutions in scenarios at 6 museums, as well as engagement with broader audiences (e.g. children, the elderly, and other potentially marginalised groups) and extension to other sectors, mainly education and tourism.
The online accessible software platform, applications for handheld devices and multisensory activities will form the basis of a technical approach that will exploit state of the art technologies – e.g. augmented reality, avatars, relief printers and models, context-sensitive tactile audio guides, metadata and advanced image processing techniques – to underpin the generation of a dynamic ecosystem. In this framework, museums will play an important role by adapting content and reinterpreting cultural heritage in manners most suitable for target groups. 
Our interdisciplinary consortium – involving academia, SMEs, research centres and museums – will focus on ensuring widespread communication and exploitation, stimulating cross-border collaboration to address a challenge common across Europe.
Let It Flow: A Static Method for Exploring Dynamic Graphs

Research into social network analysis has shown that graph metrics, such as degree and closeness, are often used to summarize structural changes in a dynamic graph. However there have been few visual analytics approaches that have been proposed to help analysts study graph evolutions in the context of graph metrics. In this paper, we present a novel approach, called GraphFlow, to visualize dynamic graphs. In contrast to previous approaches that provide users with an animated visualization, GraphFlow offers a static flow visualization that summarizes the graph metrics of the entire graph and its evolution over time. Our solution supports the discovery of high-level patterns that are difficult to identify in an animation or in individual static representations. In addition, GraphFlow provides users with a set of interactions to create filtered views. These views allow users to investigate why a particular pattern has occurred. We showcase the versatility of GraphFlow using two different datasets and describe how it can help users gain insights into complex dynamic graphs.
Single-Cell multi-omics approach to study intra-tumour heterogeneity of soft tissue sarcomas

Recently, multi-omics approaches have led to a plethora of publications describing in detail the ‘omics landscapes of common cancer types. However, at the bulk tissue level, integrating different ‘omics layers remains an uncompleted challenge. Soft tissue sarcomas are rare and often aggressive cancers of mesenchymal origin representing ~1% of all cancers but encompassing at least 50 subtypes. Hence, collecting enough of these rare samples for significant findings in a timely fashion is the biggest hurdle. This issue can be addressed by repeating observations within individual patients to generate new hypotheses. Our long-term collaboration aims to obtain the genome, transcriptome and methylome of each of 1,000 single-cells from 10 individual subtypes of soft tissue sarcomas. This design is possible thanks to DNA & RNA single-cell sequencing (SCS) of the same cell in Dr. Voet’s lab, and bespoke computational analyses in Dr. Van Loo’s lab, and access to this rare material of Prof. Flanagan, lead for the sarcoma component of the Genomics England 100,000 Genomes Project. This proposal is the pilot project, where we focus on one malignant peripheral nerve sheath tumour, a rare aggressive cancer originating from the connective tissues surrounding nerves. We will also sequence multiple regions of the primary tumour, the blood, and cell-free tumour DNA (ctDNA) before surgery and subsequently every three months. Prof. Flanagan’s group will process the samples, and Dr. Voet will oversee the sequencing. In Dr. Van Loo’s lab, I will develop the computational tools to uncover the 3 ‘omics signals at the single-cell level that are averaged out in bulk tissues. SCS will shed light on the fundamental links between cancer genomic subclones and the transcriptional and epigenetic diversity of cancer cell types; and we will answer whether ctDNA reflects the diversity of cancer cells and how it evolves in the course of treatment.
Desarrollo de la innovación de procesos en el campo de la tecnología de envasado de productos patentados, con el fin de mejorar significativamente la calidad de los servicios en PEDMO S.A.

Number_reference_aid_programa: SA.41471(2015/X) Objetivo de la ayuda pública: arte de arte: 25 Reglamento (CE) n.º 651/2014, de 17 de junio de 2014, por el que se declaran determinadas categorías de ayudas compatibles con el mercado interior en la aplicación de los artículos 107 y 108 del Tratado (DO L 119, p. Eso es todo. EU L 187/1 de 26.06.2014). Como parte del proyecto, se han planificado trabajos de desarrollo para desarrollar la innovación de procesos en el campo de la tecnología de envasado de productos patentado, gracias a lo cual el Solicitante podrá reducir la humedad del aire bajo la cubierta del producto, aumentar la eficiencia, mejorar los parámetros de los servicios de embalaje prestados, así como proponer productos propios en mejor calidad de embalaje en un plazo de entrega más corto. Cabe destacar que el proyecto desarrollará una innovación de procesos relacionada con la tecnología de embalaje original, cuyo portador será desarrollado por el equipo de investigación del solicitante, una línea tecnológica de demostración. En vista de lo anterior, el solicitante ha previsto las siguientes acciones: 1) Etapa 1 de trabajos de desarrollo consistentes en el desarrollo de un nuevo concepto tecnológico del proceso, así como la adquisición de nuevos conocimientos en el campo del impacto del proceso en los parámetros del producto sometido a agentes químicos y físicos como parte del nuevo proceso de envasado. 2) Etapa 2 de trabajos de desarrollo destinados a probar módulos individuales de la línea tecnológica, con el fin de verificar la exactitud del concepto tecnológico asumido. 3) Etapa 3 trabajos de desarrollo destinados a integrar módulos individuales de la línea tecnológica y validar la solución prototipo final. Los resultados de los trabajos de desarrollo se implementarán en la propia actividad empresarial de la empresa, lo que permitirá al solicitante introducir en el mercado un servicio de embalaje significativamente mejorado, así como la venta de sus propios productos en envases de mejor calidad.
ADJUSTMENT APPARATUS FOR A SUNROOF

An adjustment apparatus for a sunroof includes a cover support element (19), a guide element (13a, 13b), a carriage element (3), and means of control (4 through 7) for the adjustment of the cover piece. The cover support element (19), with the cover piece (8) can be tilted around a first cam (7a) and displaced. The means of control join the cover piece with the carriage element in a manner relative to each other such that they can be displaced along the aforementioned longitudinal direction. A simple design of the control system is achieved by virtue of the fact that a first connecting link (2) is provided, in which the cam (7a) is guided; the carriage element and the cover support element are joined with each other, by means of a second connecting link (5) and a second cam (7b) that is guided in it, in such a way that the first cam (7a) also moves along the second connecting link (5) when the second cam (7b) is moved in the second connecting link (5), and the first and the second guide curves (2 and 5) always form an angle with one another relative to the first and second cams (7a and 7b).
Re: Does Perineural Invasion on Prostate Biopsy Predict Adverse Prostatectomy Outcomes?

Editorial Comment: If a man has a family history of breast cancer, is he at increased risk for prostate cancer? In this brief letter the authors report on the large Swedish family cancer database. For men with a family history of prostate cancer there was a 3.4-fold increase in risk of prostate cancer if the father was affected, and 6.7 if both the father and brothers were affected. Correspondingly the risk was only 1.2 if the mother was diagnosed with breast cancer, 1.07 for an affected sister, and 1.6 when both the mother and sister were diagnosed. It appears that a family history of breast cancer has little or no effect on the risk of a man being diagnosed with prostate cancer, at least in Sweden.
From Ancient Maritime Routes to eco-touristic destinations PLUS

APPRODI PLUS is an improvement and extension of APPRODI and its overall aim is to enhance and enlarge the impact of the closed APPRODI.
APPRODI PLUS approach is based on a multimodal integration of innovative approaches:
Virtualisation: the new planning models for post-covid forms of tourism cannot disregard the creation of scenario maps linked to the overall conditions of logistical access to places, even in terms of health care and formal requirements.
Artificial Intelligence: Tourism planning approaches linked to the widespread application of artificial intelligence models (e.g., YUI website) could be a further asset for new forms of local development linked to (slow) tourism.
Inter-Sectorization: new forms of tourism planning cannot be detached from a more accurate integration with traditional and innovative sectors: Utilities, Services, Agriculture, Food, Recreation, Accommodation.

Three aspects, already developed within APPRODI project, will be further developed and valorised within the current project:
The network of the harbours signatories of the Memorandum of Understanding of the harbours which willing adopt and implement its provision. The MoU and its network had already been developed during APPRODI project. In APPRODI PLUS the contents of the MoU will be further enriched with the inputs deriving by a survey on the pandemic on the tourism activities of the harbours and solutions adopted to face and mitigate the negative effects. It is expected to enlarge the APPRODI network and 15 harbours will sign the MoU, thus enlarging the number of the harbours included in the project network.
The Interactive Map of Adriatic Historical Harbours. The map will provide focal points and hypertexts that makes the instrument attractive for the user and easy to use. Meetings and workshops will be implemented with the historical harbours to stress the tourism potentialities that can be improved; the impact of the Covid19 on the tourism and the solutions identified; historical, geographic and cultural aspects. The Interactive Map will be free accessible at a server of the LP.

The third aspect is the improvement of the perception on the historical harbours as a cultural economic asset of the territory. In each country, public events will be implemented, addressing the tourism chain audience, such as SMEs, Local Authorities, universities and research centres, interested experts and people. In parallel, on-line training will be implemented, addressing those operators of the historical harbours administrations engaged with the economic and tourism development. The contents of the training will include the role of the European Territorial Cooperation, cultural/historical, economic and financial elements
During the implementation of the project partners will establish a collaboration with its National Contact Point.
The value of information and choice to improve control.

Predictions and control about impending action and rewards or punishments require accumulating information about our environment and ultimately choosing the action that will maximize reward. Therefore, contexts containing a large amount of information about the environment and with several available options to gather reward or avoid punishment are generally preferred by agents. Because information intake and choice seeking are so important for survival and well-being, they can be considered as cognitive rewards, i.e. a higher order form of reward not directly related to immediate satisfaction like food or water. This proposal seeks to understand the neural mechanisms involved in the encoding of these cognitive rewards. 
How cognitive rewards like information and choice availability are encoded and manipulated in the brain remains a major unanswered question. Evidence suggests that cognitive rewards may be encoded by the dopaminergic system in a way similar to basic rewards like food or water.  In contexts where the amount of basic reward will be equal, I will train monkeys to perform a task where they will get either more choice or more available information related to the type of upcoming basic reward. I hypothesize that monkeys will prefer conditions where more choice or more information are available compared to condition where these variables are lacking. Using simultaneous high-density electrophysiological recordings, we predict that midbrain dopaminergic neurons will reflect these preferences. By using fiber photometry targeting specifically dopaminergic neurons, we will also investigate how the neural signal related to cognitive reward are transmitted from midbrain dopaminergic neurons to the dorsolateral prefrontal cortex and the striatum, two structures receiving massive dopaminergic inputs and previously linked with different aspects of motivational and learning processes.
Scaling all nitride photonic integrated circuits for future markets

The Sensing and Communication markets are predicted to increase tremendously over the next few years, especially pushed from medical instrumentation, diagnostics, autonomous driving, quantum computing and communication. Photonic Integration, the ability to shrink complex optical systems on a small chip, is one of the key technologies with an enabling and highly disruptive potential in those verticals.

LIGENTEC has developed a unique thick Silicon Nitride (SiN) technology which enables the manufacturing of Photonic Integrated Circuits (PICs) at better performance and lower cost than common approaches. The technology has reached TRL 7 and gained a lot of customer traction in prototyping. 

LIGENTEC has estimated its serviceable available market in the Sensing and Communication segments of €400m by 2023 and €1.5bn by 2027 respectively. First customers are ready to enter volume manufacturing in 2022/2023. 

This EIC project focus is to industrialise the manufacturing processes and prepare for scale-up including a quality control line for production and certify the technology to industry standards. It is strategic to the company as it enables LIGENTEC to enter the volume market.

At the end of this project LIGENTEC will:
•	Have World leading PIC technology for quantum, LiDAR and Space vertical at industrial scale
•	Setup and validated a quality control and metrology line
•	Have certified reference designs to industry standards allowing easier design for customers enabling new applications in new markets
•	Be ready to enter volume market and acquire customers with a need of PICs up to 1’000’000 units / year
•	Have demonstrated increased production repeatability, yield and proven product reliability

LIGENTEC is managed by an experienced team which has successfully scaled a high-tech business in photonics in the past.