SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Colours of physical origin in dyed silk

The present work reports the observations made on a collection of twenty specimens of dyed silk of Assam procured for the study related to the spectral characteristics reflected by the dyed silk in a variety of colours to suit different tastes. It is worthwhile to note that there is a direct relationship between the brightness of different colours as observed by a spectroscope and the quality (cost) of product. The aim of the present work is to set out in a systematic manners the methods and results of the experimental investigations on various aspects of the superposition of colour of physical origin. It has emerged from the studies that the observations of the spectral characteristics shall prove to be handy in silk industry in Assam.
The Impact of Credit Default Swap Trading on Loan Syndication *

We analyze the impact of CDS trading on bank syndication activity. Theoretically,the effect of CDS trading is ambiguous: on the one hand, CDS can improve risksharing
and hence be a more flexible risk management tool than loan syndication; on the other hand, CDS trading can reduce bank monitoring incentives. We document that banks are less likely to syndicate loans and retain a larger loan fraction once CDS are actively traded on the borrower’s debt. We then discern the risk management and the moral hazard channel. We find no evidence that the reduced likelihood to syndicate loans is a result of increased moral hazard problems.
Følner functions and the generic Word Problem for finitely generated amenable groups

We introduce and investigate different definitions of effective amenability, in terms of computability of F{\o}lner sets, Reiter functions, and F{\o}lner functions. As a consequence, we prove that recursively presented amenable groups have subrecursive F{\o}lner function, answering a question of Gromov, for the same class of groups we prove that solvability of the Equality Problem on a generic set (generic EP) is equivalent to solvability of the Word Problem on the whole group (WP), thus providing the first examples of finitely presented groups with unsolvable generic EP. In particular, we prove that for finitely presented groups, solvability of generic WP doesn't imply solvability of generic EP.
Evaluating the growth of genetically improved tilapia <i>Oreochromis niloticus</i> reared at different temperatures

Abstract This study aimed to evaluate the growth and performance of genetically improved tilapia reared at different temperatures. Four hundred and eighty fingerlings of Genomar Supreme Tilapia, GST (8.39 ± 0.60 g) were equally separated into three indoor water recirculation systems maintained at 22, 26 and 30 ºC. Each of four tanks contained 500 liters with 40 fish per tank in natural photoperiod. The fish were fed ad libitum with the same feed for each growth phase, weighing the total feed supplied. After 30 min of feeding, leftover feed was collected, dried in an oven and weighed. Ten fish from each tank were weighed at days 1, 30, 60, 90, 120, 150, 180 and 210. Survival, weight gain, feed conversion and feed intake in each period were determined. Fish reared at 30 ºC and 26 ºC showed a higher specific growth rate than that of fish reared at 22ºC (P≤0.05). Feed intake increased along temperature and feed conversion and was poorest in fish reared at 26ºC (P≤0.05). Final fish weight estimates at day 210 by the Gompertz model were 597.84, 819.26 and 1079.39 g for 22, 26 and 30 ºC, respectively. At 30 ºC, fish had a higher absolute growth rate (7.76 g day −1 ) and lower weight (459.30 g) and age (95.85 days) at the inflection point. Tilapia at 22 ºC had a higher weight (539.57 g) and age (197 days) and lower absolute growth rate (4.52 g day −1 ). It was concluded that GST tilapia can potentially improve aquaculture in all Brazilian regions based on different rearing temperatures.
IMPLANT FOR ARTIFICAL TEETH

The present invention is an improved implant for artificial teeth, comprising an intra-bone or endosseous insert (10, 1 10) and a false tooth set with a tooth stump (12) comprising a lower stem (13) suited to be inserted and fixed in a cavity (11) in the intra-bone or endosseous insert (10, 1 10). The insertion of the tooth stump (12) is performed by axially sliding tabs (18) that are integral with the tooth stump (12) in longitudinal access slots (17) that interrupt a portion of cavity (16a) and by successively inserting them in an annular recess (15) present in the cavity (1 1) following the rotation of the lower stem (13). At least one of the tabs (18a) is provided with at least one lug (19) that at the end of the rotation abuts against the wall of the longitudinal access slot (17) and with an upper face (20) that is inclined in the direction of rotation.
Medications and Falls: Addressing the Risk through Pharmacist-Led Quality Initiatives

Falls in older adults are common in the long-term care setting and are associated with functional decline, isolation, and depression. Increased attention is being given by Centers for Medicare and Medicaid services to have nursing homes implement quality assurance programs with the aim to reduce at least monthly medication reviews and monitors for therapeutic effectiveness as well as adverse consequences pharmacist-led team interventions to reduce fall risk in residents at a continuing care retirement community. One intervention is a fall risk evaluation form that notifies the assisted living care team of modifiable risk factors for residents who fall frequently. Examples include discontinuing psychotropic medications that effect gait or alter mental status. In conjunction with the nursing home care team, the pharmacist also created two other programs tha aim to (a) improve bone health by identifying residents who have low vitamin D levels, and evaluating their need for calcium and vitamin D supplementation, and (b) educate the nursing staff of specific medication side effects that increase fall risk.
Provably-Correct efficient algorithms for clustering

Clustering data according to similarity is ubiquitous in computer and data sciences. Similarity between data is often modeled by a distance function: two data points are close if they are similar. This induces a metric space in which each data point is associated to a point of the space. Thus, a clustering according to similarity is a partition of the points such that the distance between two points in the same part is small. Therefore, clustering problems play a crucial role in extracting information from massive datasets in various research areas. However, this problem is hard to formalise: the soundness of a particular clustering often depends on the structure of the data. This induces a gap between theory and practice: on the one hand no guarantee on the practical algorithms can be proven, on the other hand the best theoretical algorithms turn out to be noncompetitive in practice.

By focusing on both the algorithms and inputs that are relevant in practice, the PEAC project aims at rigorously analysing the cutting-edge heuristics and designing more efficient algorithms that are provably-correct for both clustering and hierarchical clustering (HC), bridging a gap between theory and practice.

Very recently, it was shown that a widely-used local search (LS) algorithm achieves the best approximation guarantees for some specific inputs. We plan to design a faster LS-based algorithm for those types of inputs to achieve both better running time and approximation guarantees than the best heuristics. We will design a non-oblivious LS algorithm to obtain a better than the current 2.675 approximation for k-median.

Dasgupta recently introduced a cost function for HC. Using this cost function, we plan to analyse the performances of widely-used heuristics for HC (e.g.: average-linkage, bisection k-means). We will characterize the real-world inputs and use the cost function to design more efficient provably-correct algorithms for HC.
Individual specialization and temporal consistency in resource use by olive ridley sea turtles (Lepidochelys olivacea)

Abstract During ontogenetic development, several types of marine vertebrates commonly switch their habitats and resources used. Stable isotopes of carbon and nitrogen in bone collagen in lines of arrested growth in humeri of adult olive ridley sea turtles ( Lepidochelys olivacea ) were analysed to detect habitat use and dietary shifts over time. Adult turtles from northeastern Brazil undergo a marked ontogenetic shift at approximately 17 years old, which is within the range of estimates of age at sexual maturity, when individuals recruit from oceanic waters to coastal waters to breed. After this period, however, some individuals seem to inhabit continental shelf waters instead of returning to offshore areas. Young adults (12 to 18 years old) and older adults (19 to 23 years old) showed similar degrees of individual specialization based on both δ 13 C and δ 15 N values. Nonetheless, older adults displayed less variable carbon and nitrogen values over time than did young adults, suggesting consistent use of the same feeding grounds as the turtles age. Overall, adults form a generalist population with specialist individuals. Isotopic niches and potential prey contributions are consistent with this classification, reinforcing the high plasticity of habitat use by olive ridleys. The individual variability and variable habitats used make olive ridleys susceptible to fisheries bycatch in neritic and pelagic habitats, where shrimp trawl and pelagic longline fisheries occur, respectively. Therefore, the year-round cycle of this species indicates the need for actions to be taken in both coastal and offshore areas to reduce adult mortality and achieve effective conservation.
A PACE IN TO REACTIVE AND PROACTIVE MODE OF CYBER SECURITY IN DATA MINING CONTEXT

The aim of this article is to describe the different modes of cyber threat and to identify major issues that appear at the different stages. Many traditional crimes are now being aided with computers and networks. Computer crimes are requiring law enforcement departments in general and criminal investigators in particular to cast an increasing amount of their efforts toward successfully identifying, apprehending, and assisting in the successful prosecution of executioner. Recently the need for new forensic techniques and tools able to investigate anti-forensics methods, and have promoted automation of live investigation. Here we try to examine the gaps that arise between reactive social control systems and proactive technology systems. Data mining can be used to model crime detection problems. Crimes are a social nuisance and cost our society exceedingly in several ways. It can also be applied for counter terrorism for homeland security.
CROSS-BORDER NETWORK OF CYCLE STATIONS WITH ASSISTED CYCLING AND APPS FOR THE INFLUX OF CYCLISTS TO LESS WELL-KNOWN ALPINE DESTINATIONS

Over the last 15 years, in the valleys of the neighboring regions of Italy and Austria, has been developed a cycle network. This netting is transited by millions of people transit every year. Because of the territorial assets, the different levels of accessibility and even the notoriety, not all the destinations with natural and cultural attractions benefit in the same way from these flows. The PARKADE project aims to "divert" these flows, allowing even less-qualified cyclists, children and senior tourists to reach the characteristic mountain village, the historic mountain, the places of the great war or environments that would, due to their difficult access, remain unknown to most. To tackle this problem, PARKADE will develop two integrated actions: 1) Implementation of a pilot action for the creation of a network of pedelecs bicycle stations, to make accessible to all the most difficult places to reach; and, thus, to achieve a valorisation of the uses, customs, local traditions, environment and territory of the smaller mountain tourist destinations. 2) The implementation of an Open Access application / APP to enable cyclists to have a tool that, in addition to being directly implemented and upgraded by tour operators themselves, will provide a "PEDELEC " - pedestrian assisted bicycle management service. PARKADE involves 6 partners and will last 24 months.
Conservation agriculture for enhancing crop productivity and resource-use efficiency

At global scale much emphasis has been given on conservation agriculture. During the last four decades intensive agriculture has been practiced by using excessive chemical fertilizers without taking care of organic manures. This leads to decline in production and profitability of farmers’ income. Rampant decline in resources forced many countries at global scale to shift towards conservation agriculture. Globally, conservation agriculture has been adopted over 106 million ha area. USA, Australia, Canada, Brazil and Argentina are leading countries. The main aim of this technology is minimal disturbance of soil, no tillage and retention of crop residue on soil surface with reduced traffic. Use of cover crops and green manuring should be included in cropping cycle. Adoption of conservation agriculture practices will lead to enhanced and sustained crop production, soil quality and sound environment which is required for sustainable agriculture.
Internacionalização do PM PROJEKT s.c. — continuação do desenvolvimento das exportações.

SA 42799(2015/X) O projeto diz respeito à participação da empresa em atividades promocionais previstas no programa de promoção da indústria de construção e acabamento de edifícios, a fim de promover a oferta da marca PM PROJEKT, que tem a oportunidade de se tornar reconhecível nos mercados estrangeiros e de promover a Marca Económica Polaca. O objeto do projeto diz respeito ao tipo de atividade da PKD 71.11.Z — Atividades no domínio da arquitetura. Os mercados em que as atividades serão realizadas no âmbito do projeto: Alemanha, Polônia, Estados Unidos Perspetiva mercados do projeto: O projeto será executado atempadamente: 12.03.2020-31.12.2021. Âmbito do projeto: realização de atividades de informação e promoção — missão externa: Bau Munique, Alemanha 2021 (situação nacional) — feiras: Varsóvia BUILD, Polónia 2021 — missão externa: Las Vegas, EUA 2021 A empresa participará em 1 evento de feira comercial como expositor e em um evento como visitante, onde será organizado um stand de informação e promoção. Realizará também uma missão no mercado de países terceiros — os Estados Unidos. A empresa também realizará atividades de informação e promoção. A empresa mantém liquidez financeira, os passivos são reembolsados a tempo. O aumento da procura de atividades de financiamento em resultado do aumento das exportações será, por conseguinte, plenamente assegurado. Até que o reembolso seja obtido, a empresa financiará os custos do projeto a partir dos seus fundos próprios acumulados na conta bancária e dos fundos das suas operações correntes.
Understanding the evolution of plasmid-mediated antibiotic resistance in real life scenarios

Antibiotics are essential tools in modern medicine and are indispensable not only for the treatment of infectious diseases but also to support other key interventions such as surgery and cancer chemotherapy. However, the extensive and inappropriate use of antibiotics has fuelled the spread of resistance mechanisms in pathogenic bacteria, leading to the dawn of a post-antibiotic era. Plasmids play a pivotal role in the evolution of antibiotic resistance (AR) because they drive the horizontal transfer of resistance genes between pathogenic bacteria by conjugation. Some of these plasmid-bacterium associations become particularly successful, creating superbugs that spread uncontrollably in clinical settings. The rise of these clones is mainly constricted because plasmids entail a fitness cost when they arrive in a new bacterial host. This cost can be subsequently alleviated through compensatory adaptation during plasmid-bacterium coevolution. Despite the importance of this cost-compensation dynamic in the evolution of plasmid-mediated AR, it remains completely unexplored in clinical contexts. In this project I plan to bridge this gap by exploring the genetic basis underlying the evolution of plasmid-mediated AR in clinically relevant scenarios. We will study, for the first time, the intra-patient transmission, fitness cost and adaptation of AR plasmids in the gut microbiome of hospitalized patients (obj. 1). We will analyse the molecular mechanisms that determine the success of AR plasmids and bacterial clone associations (obj. 2). Finally, we will develop new technology to test how antibiotic treatments affect AR plasmids dynamics in the gut microbiome at an unprecedentedly high-resolution (obj. 3). This ground-breaking project will allow a new understanding of the evolution of plasmid-mediated AR in real life, opening new research avenues and providing a major step towards meeting one of the central challenges facing our society: controlling the spread of AR.
E3-Hijacking molecular glues of rna binding protein igf2bp1 in ovarian cancer

Conventional therapeutic strategy entails developing small molecules to occupy enzymatically active or regulatory pockets of the target protein, and further inhibit its biochemical activity. However, many disease-relevant proteins, such as RAS, MYC, or b-catenin, lack manageable druggable cavities.  Bernardes and colleagues have raised a novel concept to overcome this limitation, named “molecular glues”, in which small molecules induce de-novo interactions between two proteins to modulate protein function. Molecular glues appeared as an elegant tool for targeted protein degradation, allowing simultaneous recruitment of a ubiquitin E3 ligase and the protein to be ubiquitinated. Notably, the potent anti-cancer drugs thalidomide, lenalidomide and pomalidomide (known as IMiDs for immuno-modulatory drugs), are the most prominent example of such E3-hijacking molecular glues, that exert their therapeutic effects through induced degradation of key efficacy targets.  Building on these promising observations, herein I propose a designed platform that can rationally identify synthetic chemical matter to induce selective protein dimerization and induce disease-relevant protein ubiquitination and degradation – using ubiquitin E3 ligase and RNA binding protein IGF2BP1 as a proof-of-concept in ovarian carcinoma cells. The identification of complementary interfaces for drug-induced interactions will be achieved by computational prediction, protein-protein interaction assays, and a set of novel biochemical assays, together with high-throughput screening and structure-informed chemical optimization.  This proposal will deliver a multi-layered technology to successfully design and validate novel molecular glues in a rational and generalizable way, to revolutionize current inhibitor-centric paradigms in cancer drug development and pharmacology. The strategy can be further transposed to other protein classes in different cancer types, and open an array of new therapeutic opportunities.
Communicating vesicles

Networks constituted from single components able to communicate with each other in a controlled manner are at the basis of every phenomenon occurring in the world around us. Understanding and controlling information transmission processes represents one of the greatest challenges for modern scientists. I propose to develop an understanding of the working principles of complex information processing networks by using an artificial system that resembles Nature’s cell-based communication systems. Inspired by the cascade processes occurring in Nature such as the second messenger system and extracellular messenger release, “CoVes” will be based on responsive Vesicles able to Communicate in a specific and targeted manner due to different input signals. Vesicles will be equipped with a series of synthetic transducers that respond to orthogonal external chemical stimuli. Transmembrane signalling will be coupled with internal chemical messenger release leading to communication between vesicles in an information network. The working principles of the novel multi-component ensembles will be investigated leading to systems capable of transmitting information under different diffusion conditions and paving the way for novel communication mechanisms. The accurate and reliable prediction of communication processes will lead to vesicle ensembles able to store and transfer information using orthogonal stimuli which will be crucial for the development of bio-inspired nanotechnology, such as interfaces for communication with cellular systems. The accomplishments achieved through CoVes will make chemistry not only the science of matter transformation, but also the science of information storage, elaboration and transfer.
Derivados de éster de fosfonato y métodos de síntesis de los mismos

Forma mórfica de éster mono[3-(hexadeciloxi)propílico] del ácido [[(S)-2-(4-amino-2-oxo-1(2H)-pirimidinil)-1- (hidroximetil)etoxi]metil]-fosfónico (forma A) caracterizada por un patrón de difracción de rayos X que incluye picos a 5,5, 19,3, 20,8 y 21,3 grados 2θ y una pureza superior al 91%.
Zero TEMR bone imaging in the head

Purpose To investigate proton density (PD)-weighted zero TE (ZT) imaging for morphological depiction and segmentation of cranial bone structures. Methods A rotating ultra-fast imaging sequence (RUFIS) type ZT pulse sequence was developed and optimized for 1) efficient capture of short T2 bone signals and 2) flat PD response for soft-tissues. An inverse logarithmic image scaling (i.e., −log(image)) was used to highlight bone and differentiate it from surrounding soft-tissue and air. Furthermore, a histogram-based bias-correction method was developed for subsequent threshold-based air, soft-tissue, and bone segmentation. Results PD-weighted ZT imaging in combination with an inverse logarithmic scaling was found to provide excellent depiction of cranial bone structures. In combination with bias correction, also excellent segmentation results were achieved. A two-dimensional histogram analysis demonstrates a strong, approximately linear correlation between inverse log-scaled ZT and low-dose CT for Hounsfield units (HU) between −300 HU and 1,500 HU (corresponding to soft-tissue and bone). Conclusions PD-weighted ZT imaging provides robust and efficient depiction of bone structures in the head, with an excellent contrast between air, soft-tissue, and bone. Besides structural bone imaging, the presented method is expected to be of relevance for attenuation correction in positron emission tomography (PET)/MR and MR-based radiation therapy planning. Magn Reson Med 75:107–114, 2016. © 2015 Wiley Periodicals, Inc.
Literature on the Alps

The project involves the promotion of the region and its tourist and commercial opportunities  through cultural offerings based mainly on the diffusion of knowledge  mountain literature, travel and adventure. The proposal includes two internal  similar events that already took place in the Verbano, Cusio and Ossola (Letteraltura) and  town of Brig (Berg Buch Brig). The two events, while maintaining their original appearance,  will be integrated with each other by inserting a section in each of two other organized.  Furthermore, the project provides for a conference dedicated to mountain literature which can then, in  time, include a professional space, reserved for professionals to exchange  business opportunities.