SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Role of perforin-like proteins and phospholipases in malaria parasite egress

The malaria parasite Plasmodium falciparum, which causes ~600,000 deaths annually, propagates within host erythrocytes. Roughly synchronous egress of blood stage parasites in vivo causes the periodic fevers associated with malaria and is essential for parasite replication. Blocking parasite egress can stop disease progression, so understanding its mechanism is key to identifying new drug targets. Egress of malaria parasites from host erythrocytes involves the rupture of two membranes- the parasitophorous vacuole membrane and the erythrocyte membrane. It is unclear how the parasitophorous vacuole membrane ruptures during egress, and what mechanism is responsible for poration of the erythrocyte membrane. While it has been shown that egress is protease-dependent, the effector molecules that bring about the disruption of both membranes remain unknown. Potential effector molecules include parasite perforin-like proteins (PLPs) and phospholipases.  This project aims to test the hypothesis that Plasmodium PLPs and phospholipases are involved in malarial egress. First, we will apply newly developed conditional knockout strategies to establish the role in egress of a candidate perforin-like protein. Second, we aim to devise a novel conditional genetic screen to identify egress related phospholipases in a medium-throughput manner. This work will add to the efforts being made to understand egress and will attempt to develop a much needed forward genetic screen in the malaria parasite. The interdisciplinary approach proposed here combines the experienced researcher (ER)’s skills in genomics and the host laboratory’s expertise in malarial cell biology and conditional knockout technologies. This will equip the ER with the right exposure and new skills to pursue a future independent research career in malaria research.
METHOD AND UNIT FOR RECYCLING A BITUMINOUS MEMBRANE

A method and unit for recycling a bituminous membrane provided with at least one reinforcement. Said membrane is broken into pieces which are introduced into a recycling unit provided with a first rotor, accommodated in a first stator, where they are heated and crushed. The pieces are transported to a chamber which is defined by an outer partition of the first rotor and a recess fitted in a counter element mounted on the stator, where they are pulverized. The pulverized pieces are then drained off from the chamber along the outer partition of the rotor.
NEW REINFORCING MATERIALS BASED ON S- AND Z-TWISTED YARNS FOR THE MANUFACTURE OF COMPOSITE PARTS, METHODS AND USE

The reinforcing material comprises a unidirectional reinforcing ply (2) formed of one or more carbon yarns (3) and associated on one at least of its faces, preferably on each of its faces, with a porous polymeric layer (4, 5), where the polymeric part of the reinforcing material represents from 0.5% to 10% of its total mass and preferably from 2% to 6% of its total mass, characterized in that said carbon yarns (3) are individually twisted with a twist of 3 to 15 turns/m, preferably from 6 to 12 turns/m, and comprise at least one S-twist yarn and at least one Z-twist yarn, according to a selection in accordance with claim 1.
SUBTYPE COASTLINE DETERMINATION IN URBAN COAST BASED ON MULTISCALE FEATURES: A CASE STUDY IN TIANJIN, CHINA

Abstract. In urban coast, coastline is a direct factor to reflect human activities. It is of crucial importance to the understanding of urban growth, resource development and ecological environment. Due to complexity and uncertainty in this type of coast, it is difficult to detect accurate coastline position and determine the subtypes of the coastline. In this paper, we present a multiscale feature-based subtype coastline determination (MFBSCD) method to extract coastline and determine the subtypes. In this method, uncertainty-considering coastline detection (UCCD) method is proposed to separate water and land for more accurate coastline position. The MFBSCD method can well integrate scale-invariant features of coastline in geometry and spatial structure to determine coastline in subtype scale, and can make subtypes verify with each other during processing to ensure the accuracy of final results. It was applied to Landsat Thematic Mapper (TM) and Operational Land Imager (OLI) images of Tianjin, China, and the accuracy of the extracted coastlines was assessed with the manually delineated coastline. The mean ME (misclassification error) and mean LM (Line Matching) are 0.0012 and 24.54 m respectively. The method provides an inexpensive and automated means of coastline mapping with subtype scale in coastal city sectors with intense human interference, which can be significant for coast resource management and evaluation of urban development.
COUNTER-ROTATING OPHTHALMIC SCANNER DRIVE MECHANISM

An endoprobe for ophthalmic microsurgical procedures including a hand-piece including a motor, a cannula assembly coupled to the hand-piece, and a transmission system coupling the motor to the cannula assembly is provided. The cannula assembly having an outer tube and an inner tube concentric with the outer tube, each able to rotate about the longitudinal axis and having a proximal end and a distal end. The transmission system rotates the outer tube in a first direction and the inner tube in a second, opposing direction about the longitudinal axis. A method for scanning a light beam along a linear trajectory using a cannula assembly as above is also provided.
S.U.D.C

The working group “Droit à la sécurité pour tous et diversité
culturelle: quels défis pour les politiques urbaines –
S.U.D.C.” started its work by carrying out a baseline study
of the concept and local policies already existing in the
partner cities for cultural diversity and urban security. In
order to assist with communication and exchange, a glossary
of common terms was outlined. This document includes
23 words or terms which have been defined by consensus
of the working group and can be found as an annex to the
final report.
4 main objectives were identified for the working group:
>To facilitate access to justice and human rights
>To resolve conflict
>To prevent violence
>To adapt public services
Each of these objectives was addressed by small working
groups which were made up of an expert from Liege and
an expert from each of the city partners.
Fairness-Based Resource Allocation with Minimum Rate Guarantee in a Multiuser OFDMA System

We propose a resource allocation scheme based on Proportional Fairness (PF) for minimum bit rate guarantee in a multiuser, frequency-selective frame-based OFDMA system. Instead of considering subcarrier-and-bit allocation, we consider a more realistic scheduling which is performed at the beginning of each frame, while allowing time-slots multiplexing among active users. Our scheme aims to guarantee different minimum bit rates to different users, while throughput fairness among users is maintained. We formulate the optimization problem based on a multichannel proportional fairness objective function. Minimum bit rate guarantee is taken as the constraint. The optimization problem is solved by using the Lagrange multiplier method. Then, we use our fast cross-layer approach integrated to our optimization solution to schedule packets from finitely backlogged queues. Simulations with user mobility are conducted. The results show that the proposed scheme can serve users with satisfied minimum bit rate requirement. Furthermore, the simulation results also confirm throughput fairness among users.
IMAGE PAINTING WITH MULTI-EMITTER LIGHT SOURCE

A scanning projector display includes a light engine comprising N emitters coupled to a collimator for providing a fan of N light beams of variable optical power levels, where N>1. The N emitters are spaced apart from each other such that pixels of the image simultaneously energized by neighboring ones of the N emitters are non-adjacent. A scanner receives and angularly scans the fan of N light beams about first and second non-parallel axes to provide an image in angular domain. A controller coupled to the scanner and the light engine causes the scanner to simultaneously scan the fan of N light beams about the first and second axes, and cause the light engine to vary the optical power levels of the N emitters with time delays such that adjacent pixels of the image are energized by different ones of the A emitters.
Implementation of an integrated ERP IT system supporting the business of BasenComplex Łukasz Adamski

As a result of the implementation of the project, an ERP-class IT system will be implemented supporting and informatising the processes taking place in the company involved in the construction and service of swimming pools, fountains and SPA zones, as well as installation and service of infrastructure associated with these facilities. The system will be integrated into the Applicant’s existing IT structure (computer network). The project will be implemented in Opole. The IT system will consist of the following components of the EER system: Trade, Service, Personnel and Payroll, Accounting, Inventory Book, Transfer Import, CRM, Debtor, Projects, Document Signing (Foxy-sign), Website Integration with ERP and Mobile Module (Mobile Application) which will provide access to the system via mobile devices. The system will automate workflow and automate BPM business processes – ERP will support open XML data exchange standards. Communication between the Mobile Application and the ERP database will take place via API. The following products will be created as a result of the project: Number of enterprises supported to introduce new products for the company=1 Number of ICT users = 1 Private investment complementing public support to enterprises (grants) = 87 750.00 PLN
Infants' fussiness on the breast; a window to salvage breastfeeding before breast rejection.

Infants' fussiness on the breast is a common lactation problem that can proceed to complete breastfeeding refusal if not professionally handled.To study the factors associated with infants' fussiness while breastfeeding and the effect of proper lactation counselling on the breastfeeding outcome.This is an interventional study conducted in the breastfeeding clinic of the Cairo university children's hospital. Forty-six fussy infants were recruited. Personal interview together with assessment of the act of breastfeeding were done for each mother-infant dyad. The mothers' milk letdown was assessed by manual expression. Intervention was done by proper lactation counselling, guided by the WHO/UNICEF breastfeeding counselling training course.28 (61%) of the mothers had forceful milk letdown versus 9 (19.5%) having average letdown and 9 (19.5%) having inhibited letdown (p<0.01). 13 infants were using pacifiers, which was stopped in 10 of them (p=0.01), 8 infants received formula and 5 mothers were smokers and all couldn't stop smoking. Upon counselling, 37 infants continued breastfeeding without fussiness and 9 stopped it (p<0.01). The greatest success was accomplished in mothers having forceful letdown (p=0.0001) and average letdown (p=0.01), rather than those having inhibited letdown (p=0.57). 19 of the 37 mothers having acceptable let down were presenting with perceived low milk supply and only 3 remained unconvinced (p<0.01). 46.2% of pacifier users, 100% of formula users and 80% of infants of smoker mothers quitted breastfeeding. Conclusion & Recommendations: Forceful milk letdown is commonly associated with fussiness on the breast with good outcome if properly managed. Inhibited letdown, smoking, bottle-feeding and pacifier use are associated with breastfeeding rejection. Low milk supply is a commonly "perceived" problem that should be properly assessed and handled by lactation consultants. Medical professionals should be oriented about the common breastfeeding problems, their prophylaxis and management and their role should go beyond just "motivating" mothers to breastfeed without practical guidance.
Limit theory of quadratic forms of long-memory linear processes with heavy-tailed GARCH innovations

Let X t = ∑ j = 0 ∞ c j ε t − j be a moving average process with GARCH (1, 1) innovations { ε t } . In this paper, the asymptotic behavior of the quadratic form Q n = ∑ j = 1 n ∑ s = 1 n b ( t − s ) X t X s is derived when the innovation { ε t } is a long-memory and heavy-tailed process with tail index α , where { b ( i ) } is a sequence of constants. In particular, it is shown that when 1 < α < 4 and under certain regularity conditions, the limit distribution of Q n converges to a stable random variable with index α / 2 . However, when α ≥ 4 , Q n has an asymptotic normal distribution. These results not only shed light on the singular behavior of the quadratic forms when both long-memory and heavy-tailed properties are present, but also have applications in the inference for general linear processes driven by heavy-tailed GARCH innovations.
A systematic review of studies comparing body image concerns among female college athletes and non-athletes, 1997–2012

Research prior to 2001 indicated that athletes experienced better body image than non-athletes, with no differences among sport types. Since then, female athletes have become increasingly sexually objectified in the media, and the sociocultural beauty ideal has shifted to emphasize appearing both athletic and thin. Part I of this paper explores the literature describing these changes. Part II presents a systematic and comprehensive literature review of 10 recent studies comparing body image concerns (BIC) among collegiate female athletes and non-athletes to identify the current status of BIC in female athletes. Findings indicate that involvement in collegiate athletics provides some protection from BIC; however, this protection appears attenuated for athletes in more feminine sports (e.g., gymnastics), and higher level athletes (Division I). Researchers should examine how sociocultural pressures unrelated to competition predict female athletes' BIC using measures that focus on objectification, positive body image, body functionality, and thin- and athletic-ideal internalization.
Development of management Tools and diRectives for immediate protection of bIodiversity in coasTal areas affected by sea erOsion and establishment of appropriate eNvironmental control systems

Triton project focuses on the necessity to reduce the consequences of coastal erosion and to establish appropriate environmental control systems.

The Apulian and Western Greece coastlines are facing significant erosion impacts due to natural causes (extended fetches, stormy winds, high waves and strong currents) and man-induced causes (such as urban expansion, touristic development and single-purpose coastal and/or watershed infrastructures).

Thanks to Triton project, a model of Integrated Coastal Management Zone (ICZM) between Puglia and Western Greece will be developed in order to establish decision support tools for protection of coastal areas and reduce the consequences of coastal erosion due to natural causes, such as stormy winds, high waves and strong currents, and human induced causes such as urban expansion, touristic development and infrastructures.

Main results of the project will be a toolkit of policy instruments for policy makers, a web-based participatory GIS/SIT tool empowering inhabitants and visitors to communicate effectively with the local and regional authorities, a set of shared indicators and decision support tools for the operational mapping and monitoring of coastal erosion risk.

Puglia Region is the lead beneficiary of this project in cooperation with the Italian Euro-Mediterranean Center for Climate Change and three Greek partners, the Region of Western Greece, the Network of European Cities for Sustainable Development, and the University of Patras.
Chemical composition and palaeobotanical origin of Miocene resins from Kerala-Konkan Coast, western India

The terpenoid composition of resins from the Miocene lignite horizons from the Kerala-Konkan Coast, western India was analyzed by Curie-point pyrolysis-gas chromatography-mass spectrometry (Cupy-GC-MS). The major pyrolysates were cadalene-based bicyclic sesquiterpenoids including some C30-C31 bicadinenes and bicadinanes typical of dammar resin from angiosperm plants of Dipterocarpaceae family. These plants are typically supported by tropical climates which the western Indian region was known to have experienced during early Tertiary period. The present study suggests that these palaeoclimatic conditions persisted until at least the Miocene epoch. These sesquiterpenoids which are commonly detected in many SE Asian crude oils may be utilised as useful biomarkers for petroleum exploration in the western Indian region.
TETRAHEDRAL TOP CARTON

The present invention is tetrahedral top carton (20) and a blank (100) therefor. The carton (20) has at least a nine percent material savings over a traditional gable top carton containing an equal volume of product. The carton (20) has a tetrahedral top structure (22) formed from four top panels (34, 36, 38, 40) intersecting and sealed adjacently. The carton (20) may have a fitment (24) thereon for accessing the contents. The fitment (24) may be placed on the pinnacle of the tetrahedral top structure (22) or on a single top panel (34, 36, 38 or 40). The carton (20) may have outward folded fins (62, 64, 66 and 68) projecting from the intersection of the top panels (34, 36 38, 40), or the fins may be folded inward to create diagnonal creases/edges (52, 54, 56, 58) in the intersection between adjacent top panels (34, 36, 38, 40). The carton blank (100) may also have a plurality of bottom fins (292, 294, 296, 298, 300, 302, 304) to create an overfolded bottom for reverse filling on a form, fill and seal packaging machine.
DEVICE FOR MEASURING ABERRATIONS IN AN EYE-TYPE SYSTEM

The invention relates to a device for measuring aberrations in an eye-type system comprising, in particular, an illumination path (VE) with an illumination diaphragm (APT) and a test path (VA), imaging means (L1) and means of positioning the eye (VI) in relation to said imaging means. The inventive device also comprises a stray reflection filtration element (FLT), which is centred on the measurement axis (z) of the imaging means, and means for the optical conjugation (L2, L3) of the pupil of the eye with the plane of the illumination diaphragm and the test plane. According to the invention, the illumination beam path converges at the centre of the filtration element (FLT). The filtration element, the illumination path, the test path and the conjugation means are all interdependent and positioned on a platform (PTF1) that can move in relation to the imaging means (L1) along axis z. The illumination diaphragm is off-centre in relation to the measurement axis (z) such that the stray light flux reflected in particular by the imaging means (L1) is deflected from the test path by the filtration element (FLT).
[Professor Wei Pin-kang's experience in treating chemotherapy induced nausea and vomiting: an analysis of herbal medication].

To summarize the herbal medication by Professor WEI Pin-kang's prescriptions in treating chemotherapy induced nausea and vomiting (CINV).On the basis of outpatient and inpatients' medical records concerning CINV from case-database (keywords: chemotherapy and vomiting), data of 143 patients and 143 effective prescriptions were collected. The herbs and those category, nature, flavor and meridian distribution were summarized by frequency method using SPSS 13.0 Software. The couple herbs were analyzed by hierarchical cluster analysis.A total of 144 herbs were used (2 353 frequencies). Six groups of herbs [ frequency >5%, cumulative relative frequency (CRF) 58.89%] were used frequently as follow: the herbs for regulating qi (17.81%), resolving phlegm (13.51%), invigorating qi (8.07%), relieving food retention (7.44%), calming Gan to stop endogenous wind (7.05%), and warming the interior (5.01%). The most frequently used herbs ( >20 frequencies, CRF 77.31%) had 31 species as follow: the herbs for regulating qi (6 species), calming Gan to stop endogenous wind (4 species), resolving phlegm (3 species), external application (2 species), invigorating qi (2 species), warming the interior (2 species), activating blood and removing blood stasis (2 species), promoting diuresis and resolving dampness (1 species), purgation (1 species), invigorating blood (1 species), relieving exterior syndrome with pungent-warm property (1 species), relieving exterior syndrome with pungent-cool property (1 species), astringent (1 species), resolving dampness with aromatic property (1 species), calming the mind (1 species), eliminating heat and dampness (1 species), relieving food retention (1 species). Frequency of Rhizoma Pinelliae was 127 including Rhizoma Pinelliae (processed with ginger) 83 (65.35%). Frequency of prepared Radix et Rhizoma Rhei was 85 (95.51% of Prea- praed Rhizoma Rhei). These herbs were mostly of warm nature (43.99%). The total frequency of herb-nature was 3 677 and the pungent (34.76%), bitter (32.06%) and sweet herbs (18.22%) were most frequently used (CRF 85.04%). The total frequency of meridian distribution was 6 627 and these herbs were mostly attributed to Pi, Wei, Gan, and Fei meridians (CRF 71.34%). The most frequently used couple-herbs included Rhizoma Pinelliae and Rhizoma Atisaematis, Fructus Aurantii Immaturus and Submature Bitter Orange, Flos Caryophylli and Calyx Kaki, Rhizoma Coptidis and Os Sepiae, Rumulus Ginnamomi and Radix Paeoniae, Fructus Citri Sarcodactylis and Fructus Citri, aloeswood and toad skin, scorpion and centipede, earth worm and Gekko Swinhoana, bupleurum root and curcumae, fossilia ossis mastodi and oyster, large head atractylodes and poria, and so on.Professor WEI Pin-kang regarded the therapy of dissolving phlegm and regulating Wei as the fundamental treatment of CINV. He emphasized gastrointestinal metabolic disorders induced by phlegm and stagnation related to chemotherapeutics. He laid equal emphasis on regulating qi, dissolving phlegm, and removing stagnation.
Disrupting the rail maintenance sector thanks to the most cost-efficient solution to auscultate railways overhead lines reducing costs up to 80%

On average, the rail sector spends 39,600 EUR per kilometre of track on rail infrastructure maintenance, which accounts for 38% of total operating expenses. For the rail sector it is crucial to reduce OPEX costs to increase its competitiveness.
tCat workstation is an innovative rail trolley that will contribute to drastically reduce maintenance costs related to overhead line equipment. tCat integrates, among other sensors, two laser distance meters (Competitors only use one laser) having lower and higher accuracy and being moved, in correlation, at respectively higher and lower speed. Thanks to its on-board technology tCat is able to automatically and accurately detect any overhead line elements and measure track geometric parameters.
In addition, tCat allows on-site data processing including BIM predictive maintenance services offered through SaaS model and therefore immediate maintenance actions can be taken during walking inspections, which will reduce infrastructure downtime. 
As result, thanks to tCat the overhead line maintenance processes will be performed between 5 and 6 times faster reducing costs up to 80%. This makes tCat a disruptive and unique solution in terms of cost savings and preventive maintenance operations.
In this project, the current prototype will be evolved and adapted to main markets and infrastructure characteristics. Evolved tCat models will be tested and demonstrated by some of the largest rail infrastructure operators in the EU and USA (Network Rail and ADIF). 
Our estimation is that 5 years after the launch of the product (estimated by Q4 of 2019) we will have captured about 12-14% of the EU market and 10% of USA market, becoming one of the main solutions used to perform installation, electrification and maintenance works in railways. Most important investment evaluation data are: By 2023, the company will have created more than 25 jobs and get profitability indicators as IRR 77%, NPV 2,8M€, payback time 3 years.