SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
The neural basis of visual interaction between scenes and objects

We easily categorize places and objects in a single glance, a computationally complex task presenting a central challenge for vision neuroscience. Considerable evidence points to a division of scene and object processing into two distinct neural pathways, relying on different types of visual cues. However, scenes and objects are also known to strongly interact in visual perception, as seen in contextual effects of background on object perception. At present, the neural mechanisms by which scenes and objects interact remain unknown, leaving a critical gap in our understanding of these two major visual paths. The main goal of this multi-method proposal is to uncover the neural mechanisms of scene-object interactions. I therefore propose three competing theoretical models. A parallel model predicts only stimulus-driven representations of scenes and objects in the visual cortex. In contrast, interactive models predict that representations of scenes and objects in the visual cortex are influenced by one-another. However, whereas a visual-interactive model suggests direct interaction, a feedback model suggests that the interaction is mediated by frontal regions. To test this, I propose a novel psychophysical paradigm of seeing objects from scene context and scenes from object context. Thereby, I will examine how scene and object processing are affected by one-another and identify the potential neural sources of these modulations using fMRI (objective 1). Thereafter, I will use MEG to decode the timeline of these neural processes (objective 2). Establishing a clear neurocognitive model for scene-object interaction would not only advance our understanding of the two central paths of the ventral visual stream, but also significantly contribute to the definition of vision as an interactive system rather than a set of specialized parallel modules. Shifting from localized visual modules to interactive visual processes will broaden my expertise as a cognitive neuroscientist.
Exploring the Mechanism of Zanamivir Resistance in a Neuraminidase Mutant: A Molecular Dynamics Study

It is critical to understand the molecular basis of the drug resistance of influenza viruses to efficiently treat this infectious disease. Recently, H1N1 strains of influenza A carrying a mutation of Q136K in neuraminidase were found. The new strain showed a strong Zanamivir neutralization effect. In this study, normal molecular dynamics simulations and metadynamics simulations were employed to explore the mechanism of Zanamivir resistance. The wild-type neuraminidase contained a 3(10) helix before the 150 loop, and there was interaction between the 150 and 430 loops. However, the helix and the interaction between the two loops were disturbed in the mutant protein due to interaction between K136 and nearby residues. Hydrogen-bond network analysis showed weakened interaction between the Zanamivir drug and E276/D151 on account of the electrostatic interaction between K136 and D151. Metadynamics simulations showed that the free energy landscape was different in the mutant than in the wild-type neuraminidase. Conformation with the global minimum of free energy for the mutant protein was different from the wild-type conformation. While the drug fit completely into the active site of the wild-type neuraminidase, it did not match the active site of the mutant variant. This study indicates that the altered hydrogen-bond network and the deformation of the 150 loop are the key factors in development of Zanamivir resistance. Furthermore, the Q136K mutation has a variable effect on conformation of different N1 variants, with conformation of the 1918 N1 variant being more profoundly affected than that of the other N1 variants studied in this paper. This observation warrants further experimental investigation.
Cell-Surface immobilized vs. internalized magnetic nanoparticles for magnetic hyperthermia studies

The MSC OUTstandINg project will use bioorthogonal click chemistry as tool to covalently attach magnetic nanoparticles (MNPs) to living cell surfaces with the aim to address two fundamental questions in the field of magnetic hyperthermia therapy using MNPs: 1) how the subcellular localization (on the plasma membrane or inside the cells) of MNPs affects their heating behaviour when compared to MNPs in solution 2) how MNPs immobilization and sub-lethal magnetic hyperthermia impact different subcellular signalling pathways and the biophysics of cell membranes. 
OUTstandINg is a multidisciplinary two-years research project built upon the expertise of the Fellow (Dr. Raluca M. Fratila) in bioorganic chemistry (including click chemistry, bioconjugates and functionalization of surfaces and (nano)materials) and the experience of the supervisor (Dr. Jesús Martínez de la Fuente) and of the host group (GN2 - Nanotherapy and Nanobiosensors, University of Zaragoza, Spain) in nanotechnology and nanomedicine. This MSC action will offer the Fellow the possibility to work in one of the top European institutions in nanoscience, where she will further develop her skills and will acquire new skills and knowledge necessary for the progress of her scientific career towards an independent position. The secondment period at University College London Institute for Biomedical Engineering (supervisor Prof. Quentin Pankhurst) will reinforce and complete the multidisciplinary training-through-research. The project will generate important knowledge and collaborations in the European Research Area (ERA) and will contribute to enhance the excellence of ERA through cutting-edge research at the frontier of chemistry, physics, materials science, cell biology and nanotechnology.
Synthesis, curing behavior, and thermal properties of fluorene-based benzoxazine-endcapped copoly(ether ketone ketone)s

A series of fluorene-based benzoxazine-endcapped copoly(ether ketone ketone)s (co-PEKKs) were successfully synthesized, in which the co-PEKKs were prepared with different molar ratios of 2,7-dihydroxy-9-fluorenone to bisphenol-A. The obtained phenol-ended co-PEKKs reacted with formaldehyde and n-butylamine to yield the benzoxazine-endcapped co-PEKKs (B-PEKKs). The structure of these oligomers was studied by Fourier transform infrared spectroscopy and 1H nuclear magnetic resonance spectroscopy, and the molecular mass of these phenol-ended co-PEKKs was detected by gel permeation chromatography. The thermal behaviors of these B-PEKKs were determined by differential scanning calorimetry. In addition, the thermal and dynamic mechanical properties of the polymer films were investigated by thermogravimetric analysis and dynamic mechanical analysis. The results indicate that the incorporation of co-PEKKs within the benzoxazine backbone considerably improves the toughness of the fluorene-containing polybenzoxazines without much sacrifice of their thermal properties. Furthermore, as the content of 2,7-dihydroxy-9-fluorenone increases, the T5 values decrease, while the Tg values and char yields of the prepared polymers increase to reach their highest values at 256 °C and 64 %, respectively.
Expression of dishevelled gene in Hirschsprung's disease.

Hirschsprung's disease (HSCR) is a congenital disorder of the enteric nervous system and is characterized by an absence of enteric ganglion cells in terminal regions of the gut during development. Dishevelled (DVL) protein is a cytoplasmic protein which plays pivotal roles in the embryonic development. In this study, we explore the cause of HSCR by studying the expression of DVL-1 and DVL-3 genes and their proteins in the aganglionic segment and the ganglionic segment of colon in HSCR patients.Specimen of aganglionic segment and ganglionic segment of colon in 50 cases of HSCR patients. Expression levels of mRNA and proteins of DVL-1 and DVL-3 were confirmed by quantitative real-time PCR (qRT-PCR), western blot and immunohistochemistry staining between the aganglionic segment and the ganglionic segment of colon in HSCR patients.The mRNA expression of DVL-1 and DVL-3 were 2.06 fold and 3.12 fold in the aganglionic segment colon tissues compared to the ganglionic segment, respectively. Similarly, the proteins expression of DVL-1 and DVL-3 were higher (39.71 ± 4.53 vs and 53.90 ± 6.79 vs) in the aganglionic segment colon tissues than in the ganglionic segment (15.01 ± 2.66 and 20.13 ± 3.63) by western blot. Besides, immunohistochemical staining showed that DVL-1 and DVL-3 have a significant increase in mucous and submucous layers from aganglionic colon segments compared with ganglionic segments.The study showed an association of DVL-1 and DVL-3 with HSCR, it may play an important role in the pathogenesis of HSCR.
METHOD OF FABRICATING CONTACT ELEMENTS IN AN ELECTROCHEMICAL DEVICE SUCH AS SOFC OR EHT

The invention relates to a method of fabricating a contact element in an electrochemical device (9) such as an SOFC or an EHT which comprises the following steps: a) use is made of: at least one cell (8) consisting of an assemblage made up of an electrode to be hydrogenated (5) - electrolyte (4) - electrode to be oxygenated (3); at least one first interconnector (1); and at least one second interconnector (7); b) at least one layer of a conducting material is deposited on the first interconnector (1) and/or the second interconnector (7); c) an electrochemical device (9) is assembled; said method being characterized in that: d) a thermomechanical treatment is carried out on the electrochemical device obtained on completion of step c). The invention also relates to an electrochemical device (9) equipped with at least one contact element (2) obtained according to this fabrication method.
METHOD FOR COLOURING TEXTILES, COMPRISING THE USE OF AN ORGANOSILICON COMPOUND, A REACTIVE COLOURING AGENT AND/OR A PIGMENT

The present invention relates to a method for colouring textile materials, comprising the following steps: use of an agent (a) on a textile material, wherein the agent (a) contains at least one organosilicon compound, and use of an agent (b) on the textile material, wherein the agent (b) contains at least one reactive colouring agent and/or at least one pigment. The invention also relates to a two-component composition comprising two components with the agents (a) and (b).
Improvements in and relating to circular weaving looms

659,417. Circular looms. SAINT FRERES SOC. ANON. Jan. 25, 1949; No. 1999. Convention date, Jan. 28, 1948. [Class 142(ii)] Each shuttle is followed by a rubber-clad roller 1 driven at a peripheral speed which is slightly higher than its orbital speed, so that it lifts the warp threads 12 and deposits them behind their previous position to counteract the tendency of the shuttles to drag the threads round the loom. When the shuttles are driven by rollers 3, the roller 1 is on the same shaft as the roller 3 and is of slightly greater diameter. The weft laying arms on the shuttles carry barbs which pluck the warp threads to equalize their spacing before they are lifted by the roller 1.
Process and device for preparing tooth fillings.

Zur Herstellung von Füllungen in Zähnen mittels Stopfgold wird Goldpulver in die Kavität eingebracht und dieses anschließend mechanisch verfestigt. Die Feuchtigkeitsempfindlichkeit dieses Verfahrens kann man vermeiden, wenn man eine Paste aus plättchenförmigen Goldpulver mit einem bei 20 bis 45°C sich verflüssigenden, plastischen organischen Bindemittel verwendet und die mechanische Verfestigung unter Einwirkung von Ultraschall erfolgt.
A dual-band dual-polarized steerable pattern reconfigurable antenna

A novel low-profile dual-band steerable pattern-reconfigurable antenna (PRA) is presented in this paper. The antenna consists of two parallel fed radiating elements with a pair of varactors acting as a loaded-line phase shifter. A DC bias voltage applied to the varactors controls the phase delay between the currents feeding each element and the imbalance in current flow modulates the pattern. The design and full wave simulation of the antenna are presented. The proposed antenna provides dual polarized 25° beam steering in the elevation plane in both the 3.51-GHz and 3.67-GHz band. Unlike existing PRAs that employ multiple PIN diodes to switch through discrete radiation profiles, this antenna changes its pattern continuously using a single control signal while maintaining a good input response without the need for a sophisticated matching network.
Expert Opinion on Laparoscopic Surgery for Colorectal Cancer Parallels Evidence from a Cumulative Meta-Analysis of Randomized Controlled Trials

This study sought to synthesize survival outcomes from trials of laparoscopic and open colorectal cancer surgery, and to determine whether expert acceptance of this technology in the literature has parallel cumulative survival evidence.A systematic review of randomized trials was conducted. The primary outcome was survival, and meta-analysis of time-to-event data was conducted. Expert opinion in the literature (published reviews, guidelines, and textbook chapters) on the acceptability of laparoscopic colorectal cancer was graded using a 7-point scale. Pooled survival data were correlated in time with accumulating expert opinion scores.A total of 5,800 citations were screened. Of these, 39 publications pertaining to 23 individual trials were retained. As well, 414 reviews were included (28 guidelines, 30 textbook chapters, 20 systematic reviews, 336 narrative reviews). In total, 5,782 patients were randomized to laparoscopic (n = 3,031) and open (n = 2,751) colorectal surgery. Survival data were presented in 16 publications. Laparoscopic surgery was not inferior to open surgery in terms of overall survival (HR = 0.94, 95% CI 0.80, 1.09). Expert opinion in the literature pertaining to the oncologic acceptability of laparoscopic surgery for colon cancer correlated most closely with the publication of large RCTs in 2002-2004. Although increasingly accepted since 2006, laparoscopic surgery for rectal cancer remained controversial.Laparoscopic surgery for colon cancer is non-inferior to open surgery in terms of overall survival, and has been so since 2004. The majority expert opinion in the literature has considered these two techniques to be equivalent since 2002-2004. Laparoscopic surgery for rectal cancer has been increasingly accepted since 2006, but remains controversial. Knowledge translation efforts in this field appear to have paralleled the accumulation of clinical trial evidence.
ROME POUR LES ENFANTS 2.0

LE PROJET VISE À METTRE EN ŒUVRE LE SITE AFIN DE LE RENDRE PLUS ACCESSIBLE AUX UTILISATEURS ET AUX CLIENTS QUI ACHÈTENT LA PUBLICITÉ. LES INTERVENTIONS PORTERONT DONC SUR LE MARKETING NUMÉRIQUE, LA RÉSERVATION ET LE PAIEMENT ET LA SÉCURITÉ NUMÉRIQUE.
Industrial thermal energy reuse enabled by sorption heatpumps

This work will further strengthen R&D skills of the applicant, especially considering the development of efficient sorption heat pump systems, extend his technical and nontechnical network, increase his knowledge regarding market demands and strategies and provide new career perspectives. 
The project aims at accelerating development and application of hybrid resorption heat pump for more energy efficient use of heat. 
A recast of European Performance of Buildings Directive indicated that higher energy efficiency is required for heating and cooling in building and industrial sector. Heat pumps can provide such efficient use, among which sorption heat pump could be a promising candidate. Due to various sorption working pairs, the heat with a wide temperature range could be recovered which almost saves 50% energy through desorption and sorption process compared to direct heating systems. So far, this technology has not been commercially realized in large-scale application or served as an auxiliary application. 
The project objectives are elaborated as follows:
1. Screen potential thermo-chemical sorbents with higher energy density through comprehensive review, develop and test the promising composite materials.
2. Develop a transient model for hybrid resorption heat pumps.
3. Design, construct and test a pair of resorption reactors that can operate over 1000+ cycles without noticeable loss of reactivity, and to be integrated with compressor for completing resorption system.
4. Conduct techno-economic analysis of hybrid heat pump for real industrial application.
This proposal combines the applicant’s expertise concerning heat/mass transfer and reaction kinetics of sorbents with thermal engineering skills & experience of Dr. Carlos Infante Ferreira at TUDelft to achieve the high energy efficient sorption heat pump. These synergies will deliver a successful project as measured by well-defined deliverables, both in terms of hardware development and disseminated knowledge.
Self-enforcing environmental agreements and trade in fossil energy deposits

Abstract The literature on self-enforcing environmental agreements (SIEAs) focuses on de- mand-side emission-reduction policies. To our knowledge, Harstad (2012) is the only study on SIEAs, in which countries purchase fossil-energy deposits to prevent their exploitation. He finds that for any coalition size there exists a (small) subset of parameters, different for each size, such that the coalition of that size is stable. However, the comparison of Harstad's results with the prevailing demand-side SIEA analyses is hampered by major differences in the structure of the respective game models. This paper develops a game model with a deposit market and deposit purchases for preservation that is in line with some demand-side SIEA literature. It turns out that either no coalition is stable or the grand coalition is the only stable coalition. We compare the outcome of our model not only with Harstad's model but also with Eichner and Pethig's (2015) model of the formation of SIEAs in which climate policy takes the form of (demand-side) emissions taxes.
Forgotten fathers: paternal influences on mammalian sex allocation

Sex allocation research in mammals has focussed almost exclusively on mothers under the assumption that the male contribution is genetically determined during meiosis and therefore not under adaptive control. Although early studies on sperm traits suggested that sex ratios were at parity, technological advances have made analysis more reliable and cheaper. Subsequently, more studies have shown variation in the production of X-/Y-chromosome-bearing spermatozoa. We review the evidence that the X/Y ratio varies between and within individuals in mammals, and test whether there are consistent predictors of these sex ratio biases and finally discuss their implications for future studies on sex allocation.
Soft artificial muscles

The development of bioinspired materials that mimic animal muscles is a key step in the advancement of several scientific fields, including robotics and medicine. Muscles exhibit a unique combination of softness, mechanical resistance, adaptability and the ability to undergo large anisotropic deformations, which is so far unmatched in artificial materials. This action will develop a novel class of nanocomposite materials that mimic natural muscles by combining stimuli-responsive hydrogels (SRH) and colloidal liquid crystals (CLC). 
SRHs consist of a network of stimuli-responsive polymer chains and a high fraction of water. By changing the solubility of the polymer with stimuli such as temperature and light it is possible to control the amount of water in the network, thereby producing large volumetric variations. SRHs are soft and shape-compliant actuating materials like muscles, but they generally exhibit poor mechanical resistance and the volumetric expansion has no preferential direction. These limitations will be overcome by attaching the stimuli-responsive polymer chains to anisotropic colloidal particles and assembling these building blocks in a uniaxially oriented manner like CLCs. The resulting nanocomposites will be soft, yet strong, capable of actuation-like conventional SRHs, and their expansion/contraction will be directional, thanks to the preferred orientation of the colloidal particles. 
The proposed platform will rely on rod-like cellulose nanocrystals (CNCs) that will be decorated with cross-linkable poly-N-isopropylacrylamide chains bearing photoresponsive spiropyran units (poly-spiropyrans, PSPs). CNCs are inexpensive, biocompatible and can be easily extracted from renewable resources, while PSPs are known to form photoresponsive hydrogels. The combination of these elements and integration into uniaxially oriented structures will afford a novel class of soft actuators that will bring significant advancement to fields like robotics and medicine.
For a better tomorrow: social enterprises on the move

The project “For a Better Tomorrow: Social Enterprises on the Move (FAB-MOVE)” brings together researchers and practitioners in order to explore the question of how social enterprises can grow and flourish. These objectives will be achieved through a carefully crafted network of academic and non-academic partner organisations co-operating worldwide.
Managers and practitioners of social enterprises often lack an easy access to the frontiers of science. FAB-MOVE will significantly improve the transfer of knowledge between academics and non-academics and thus increase the practical applicability of research findings. For an enduring sustainable impact, FAB-MOVE develops a teaching tool to educate (future) managers of social enterprises on how to set up their enterprise in a specific environment, how to combine business with a social goal, and how to develop strategies for growth and scaling-up. 
Currently there is a lack of knowledge about the influence of different social and economic environments on social enterprises. Local eco-systems and traditions have a decisive impact on the wellbeing, growth and potentials for scaling-up of social enterprises. FAB-MOVE focuses on the embeddedness of social enterprises and its impact on their evolution. It identifies crucial success factors for a sustainable development of these new and innovative organisations in an internationally comparative perspective.
Thoroughly analysed case studies will serve as best practices by highlighting how social enterprises overcome crucial problems and manage to grow in different social areas and various regions around the world. In particular, the cases will shed light on how managers of social enterprises cooperate with stakeholders and how their environment composed of promoting actors and existing (political) structures meet their needs in order to improve social cohesion all over Europe.