SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Rational design of cancer immunotherapy: one size does not fit all

Checkpoint blockade immunotherapies have revolutionized cancer treatment. However, this immunotherapy only benefits a minority of patients (< 15%), mainly those diagnosed with cancers having many mutations. Furthermore, checkpoint blockade therapy does not selectively activate cancer-reactive T cells.
RARITY responds to these shortcomings, aiming to provide innovative solutions for the development of effective immunotherapies for patients who do not benefit from current treatments. The ground-breaking preliminary data included in this application demonstrates that cancer-reactive T cells can be naturally present in so-called non-immunogenic cancers and that they acquire distinctive phenotypes. RARITY will apply state-of-the-art technologies to fingerprint these phenotypes. This will allow the isolation of cancer-reactive T cells from tumour tissues and their employment as highly-effective therapies. Therapeutic vaccination with cancer antigens can also be used to induce T cell responses in patients where natural activation of cancer-specific T cells is not detectable. However, the applicability of vaccination is compromised by the lack of specific targets, particularly in malignancies with few mutations. RARITY will address this problem by deploying a novel class of cancer antigens. An unprecedented screening of non-exomic genomic regions will be done to detect unannotated proteins that arise from de novo transcription and translation events. These proteins can then be targeted by personalized immunotherapies. Finally, thought-provoking findings included in RARITY suggest that immune cell subsets other than T cells play a major role in anti-tumour immune responses. These subsets need to be fully inventoried and categorised so that complementary strategies to T cell immunotherapies can be developed. RARITY will do so by conducting multidimensional analysis of cancer microenvironments using imaging mass cytometry and ex vivo modulation of immune responses.
ASYMMETRIC RADIAL SPLINE SEAL FOR A GAS TURBINE ENGINE

A shroud apparatus for a gas turbine engine includes: an annular shroud segment (26) having an arcuate bottom wall (52) defining an arcuate inner flowpath surface(62), spaced-apart forward and aft walls (54, 56) extending radially outward from the bottom wall (52), and spaced-apart side walls (58) extending radially outward from the bottom wall (52) and between the forward and aft walls (54, 56), each side wall (58) defining an end face (74) which includes: an axial slot (76) extending in a generally axial direction along the end face (74); a first radial slot (78) extending in a generally radial direction along the end face (74), and intersecting the axial slot (76); an axial spline seal (82) received in the axial slot (76); and a first radial spline seal (84) having an L-shape with radial and axial legs (88, 90), the radial leg (88)being substantially longer than the axial leg (90), wherein the radial leg (88) is received in the first radial slot (78), and the axial leg is received in the axial slot (76).
Simulation, model‐reduction, and state estimation of a two‐component coagulation process

The issue of state estimation of an aggregation process through (1) using model reduction to obtain a tractable approximation of the governing dynamics and (2) designing a fast moving-horizon estimator for the reduced-order model is addressed. The method of moments is first used to reduce the governing integro-differential equation down to a nonlinear ordinary differential equation. This reduced-order model is then simulated for both batch and continuous processes and the results are shown to agree with constant Number Monte Carlo simulation results of the original model. Next, the states of the reduced order model are estimated in a moving horizon estimation approach. For this purpose, Carleman linearization is first employed and the nonlinear system is represented in a bilinear form. This representation lessens the computation burden of the estimation problem by allowing for analytical solution of the state variables as well as sensitivities with respect to decision variables. © 2016 American Institute of Chemical Engineers AIChE J, 62: 1557–1567, 2016
Macau: Large-scale skill sense disambiguation in the online recruitment domain

Named entity sense disambiguation is a problem with important natural language processing applications. In the online recruitment industry, normalization and recognition of occupational skills play a key role in linking the right candidate with the right job. The disambiguation of multisense skills will help improve this normalization and recognition process. In this paper we discuss an automatic large-scale system to identify and disambiguate multi-sense skills, including: (1) Feature Selection: employing word embedding to quantify the skills and their contexts into vectors; (2) Clustering: applying Markov Chain Monte Carlo (MCMC) methods to aggregate vectors into clusters that represent respective senses; (3) Large-scale: implementing parallelization to process text blobs on a large-scale; (4) Pruning: cluster cleaning by analyzing intra-cluster cosine similarities. Based on experiments on sample datasets, the MCMC-based clustering algorithm outperforms other clustering algorithms for the disambiguation problem. Also based on data-driven in-house evaluations, our disambiguation system achieves 84% precision.
Triggering haematological adoptive t-cell immunotherapy strategies by hunting novel t-cellreceptors

Recent encouraging clinical results obtained with engineered T lymphocytes and increasing advances in the genome editing field, have opened new opportunities for T-cell receptor (TCR) gene therapy as an immunotherapeutic approach for cancer.
Unfortunately, the broad applicability of this treatment is still hampered by the possible mispairing of exogenous/endogenous TCR chains and by the limited number of high avidity tumor-specific TCRs. While the first issue has been successfully addressed by the hosting lab with the development a TCR gene editing protocol, the identification of novel tumor-specific TCRs is urgently required and this is the aim of my research proposal. We have the unique opportunity to combine the highly complementary expertise of the hosting lab in T-cell biology/genetic transfer and of the applicant on immune repertoire sequencing. We will target acute myeloid leukemia (AML) and hypothesize that by exploiting intrinsic features of AML (i.e. ability of AML blasts to differentiate into potent antigen presenting cells expressing tumor antigens), the functional fingerprint induced by AML on tumor-reactive T-cells, and cutting-edge technologies (i.e. next generation sequencing; ligandome landscape analysis), we will provide a comprehensive immunoprofiling of tumor-specific T-cells and isolate tumor TCR specificities. Results obtained in this study will streamline TCR hunting studies in solid tumors, leading to the generation of a TCR library for different antigens and HLA restrictions, thus rendering TCR gene editing an innovative off-the-shelf treatment available for a high number of cancer patients. Awarding this fellowship will greatly enhance researcher’s career not only by providing the opportunity to widen scientific knowhow and acquire new skills, but also by enabling the researcher to address a major bottleneck currently limiting the full exploitation of the rapidly growing field of cancer immunotherapy.
Democratic participation in territorial states

Who should have a right to participate in the making of political decisions? Political theorists have thus far approached this important moral question in two ways. Theorists of territorial rights argue that the right to make laws on particular territories belongs to groups, such that a person’s enfranchisement derives from her group membership. In contrast, democratic theorists argue that states should enfranchise anyone affected or subjected by their laws, regardless of group membership; if not, their lawmaking is undemocratic. This creates an intriguing dilemma. As they stand, the prominent theories preclude a straightforward dual commitment to democratic decision-making and collective territorial rights: we must either give non-members a say over a group’s lawmaking on ‘its’ territory, or withhold various individuals’ right to a democratic say.

DEPART solves this impasse. It will conduct the first systematic exploration of how theories of territorial rights and democratic participation may be plausibly combined, and thus develop a unified theory of rights of democratic participation (through voting) in territorial states. The project will use what is known as the method of reflective equilibrium – a common methodology within the Anglo-American (or ‘analytical’) tradition of normative political theory/political philosophy.

DEPART will achieve several valuable goals. First, by showing how insights from apparently disparate approaches may pull in the same direction, its unified theory gives a promising framework for fruitful future research on territorial rights and democratic participation. Second, it gives policy-guidance on several issues on the EU agenda, including whether EU citizens living in another member state should have a say in that state’s national elections – an issue recently raised by the Commission. Third, when communicating its action and results, it reinforces public awareness of the value of democratic participation (especially among youths).
Volunteer activity in end–of-life care: a national survey of current practice

Introduction Specialised end-of-life care supports patients and families during the last months of life and, in the UK, is commonly provided either in a hospice or in a patient9s home. Demand for such care in the UK will increase with mortality rates predicted to rise from 2012 to 2030 by 17%. The precise number and contribution of volunteers is unknown. However, it is estimated that there are over 100,000 volunteers working in UK hospices and that their contribution reduces costs by around 25%. The current economic situation is likely to limit funding. This means it is essential that we understand where volunteers are currently deployed to enable planning to be based on real practice. Aims and Methods Focusing on volunteers in direct contact with patients and families this survey seeks to establish the extent of volunteer activity in UK end-of-life specialised care. A web-based nationwide survey of end-of-life care organisations, targeted at over 200 managers of volunteer services, including managers of hospices and home care teams. Results The results, which will be available, will be analysed using descriptive statistics. They will give an overview of volunteer involvement in supporting patients and families in end-of-life care, detailing aspects volunteers are involved in and establishing which services are often volunteer-led. Conclusion This will be the first UK-wide survey of its kind. It will highlight where further evaluation and development should be focused.
Method for realizing route forwarding in network

A method for realizing route forwarding in a network, including: establishing LSPs in a bearer network; setting an entrance label in the starting node of each LSP pointing to forwarding information of the LSP; a bearer control entity assigning a transfer path for the service flow and sending the information of all corresponding entrance labels of the transfer path to the ingress edge node of the transfer path; when the service flow needs to be forwarded, the ingress edge node puts the label stack into the data packet of the service flow to generate an MPLS exchange packet; and forwarding the MPLS exchange packet in the bearer network according to the label stack until the packet reaches the egress edge node of the transfer path. The present invention grants high compatibility to the network, minimizes the network investment, and reduces the difficulties in network implementation.
Somatotopic dominance in tactile temporal processing

The sense of touch is initiated by stimulation of peripheral mechanoreceptors, and then the spatio-temporal pattern of the receptors' activation is interpreted by central cortical processing. To explore the tactile central processing, we psychophysically studied human judgments of the temporal relationships between two tactile events occurring at different skin locations. We examined four types of two-point temporal judgments-simultaneity, temporal order, apparent motion, and inter-stimulus interval-which differ from one another in time scale and task requirement. To perform any of the four temporal judgment tasks, the brain has to integrate spatially separated inputs. The main focus of the present study is to examine how the spatial separation affects the temporal judgment tasks. Two spatial coordinates can be defined in touch: the somatotopic coordinate, defined by cortical topography, and the spatiotopic coordinate, defined in the environment. In our experiments, the somatotopic distance was manipulated by stimulating the middle and index fingers of the same hand or different hands (ipsilateral vs. bilateral conditions), while the spatiotopic distance was manipulated by increasing the stimulators' separation under bilateral conditions (bilateral-near vs. bilateral-far conditions). Our results clearly demonstrated that all four of the temporal judgments were significantly affected by the somatotopic distance, but only slightly by the spatiotopic distance. The present results, together with the previous findings, suggest that tactile temporal judgments in a wide range of time scale, from several to several 100 ms, primarily reflect processing at the level of somatotopic representation unless the performance is further constrained by spatial processing.
Reliability principles, methodology and methods for lifetime design

The aim of integrated lifetime design is to predict and optimise the lifetime quality of the designed facility (building, bridge, tunnel, harbour, road, railway, airport, etc.). Lifetime quality means the capability of a facility or its structures to fulfil the requirements of its users, owners and society over its entire planning and design life (usually 50–100 years). The dictating phase for optimising the lifetime quality of a facility or structure is the planning and design phase, when the degree of freedom is high, and the cost of the phase is low. Generic limit state design aims to fulfil the generic requirements of lifetime quality. At the integrated planning and design stage, performance-based and generic structural limit states design includes the following three classes: (1) Static and dynamic modelling and design against mechanical loads; (2) Durability and service life modelling and design against degrading physical, chemical and biological loads; (3) Usability and service life modelling and design against obsolescence loads. As static and dynamic design are comprehensively dealt with in the literature and in practice, this report focuses on the lifetime safety factor method for durability design and obsolescence design. Main focus of this article is in durability design. On the obsolescence design are presented only a short summary and a number of references, because this design is not much connected to materials research.
Building the ADRION Brand Name in Tourism: Indulging all Five Senses PLUS

The ADRION 5 SENSES PLUS Project aims to raise awareness of the ADRION 5 SENSES Project results, to update and fully exploit its outcomes. The ADRION 5 SENSES Project was focused on the ADRION area, studied in-depth the area’s high potential for further development of sustainable tourism, and successfully addressed the common territorial challenge which is the lack of a sustainable tourism model based on innovative, high-quality tourism products and services. In the last couple of years, our reality has changed completely, the Covid-19 pandemic has challenged the tourism model of the ADRION area, raised questions around the health and safety in tourism and has made the whole world rethink travelling and the sustainability of the tourism sector. The ADRION 5 SENSES PLUS comes in a time of need and aims to offer the opportunity to the ADRION 5 SENSES Partnership to revise and update their ADRION 5 SENSES Joint Strategy and Action plan in order to address the new challenges that arise from Covid-19 and to draw a long-term direction regarding sustainable tourism and destination management for the ADRION area which will be adopted by the ADRION 5 SENSES Transnational Network. The ADRION 5 SENSES Transnational Network is committed to continuing the collaboration and work towards creating a sustainable tourism model for the ADRION area and the ADRION 5 SENSES PLUS will further support their work towards the long-term sustainability of the Project results and the creation of a more sustainable and resilient tourism sector. Last but not least, the ADRION 5 SENSES PLUS offers the chance to the Partners and Stakeholders involved to further promote the ADRION 5 SENSES Outputs (i.e., Map of Sensations, Multilingual Web Platform and Exhibition Centres) and to raise awareness of the integrated approach- sensory marketing – which is new and innovative for the ADRION area. The aim of the ADRION 5 SENSES PLUS is to build and promote the ADRION brand name in tourism by indulging all five senses of tourists and by inspiring more stakeholders to join the ADRION 5 SENSES Transnational Network. The vision of the ADRION 5 SENSES PLUS Partnership is to use the available ‘tools’ created by the ADRION 5 SENSES Project, re-start tourism in the ADRION area and enable people to travel, meet, ‘feel’ -get an authentic experience of the area -  the ADRION destinations with safety.
SISTEMA DE REGULACION DE LA CARGA O PAR MOTOR PARA MOTOR DUAL, DE COMBUSTION HOMOGENEA DE ENCENDIDO POR COMBUSTION HETEROGENEA

Sistema de regulacion de la carga o par motor para motor DUAL, de combustion homogénea de encendido por combustion heterogénea. El sistema de la presente comprende una válvula de estrangulamiento de la admision, una inyeccion de gasoil para cada régimen de giro y condicion de funcionamiento, y una aportacion de combustible principal para conseguir una realizacion aire/combustible global objetivo predeterminada en el que se regula la carga o par motor a partir de la variacion del flujo de admision que provoca la citada válvula de estrangulamiento de la admision.
Abstraction for model checking modular interpreted systems over ATL

We propose an abstraction technique for model checking multi-agent systems given as modular interpreted systems (MIS) which allow for succinct representations of compositional systems. Specifications are given as arbitrary ATL formulae, i. e., we can reason about strategic abilities of groups of agents. Our technique is based on collapsing each agent's local state space with hand-crafted equivalence relations, one per strategic modality. We develop a model checking algorithm and prove its soundness. This makes it possible to perform model checking on abstractions (which are much smaller in size) rather than on the concrete system which is usually too complex, thereby saving space and time.
A fully robotic and 3d printing solution for large scale building delivery

3D Printing for construction sector is booming in the last few years, emerging as an automated manufacturing process that produce complex shape geometries automatically from a 3D computer design model. Although construction 3D Printing has become a revolutionary technology for building, the industry will have to face many challenges related to scalability, work at heights, delivery system, suitability to adverse environment and initial investments. Aware of the limitations of current 3D printing systems for construction, we have developed Evo Constructor, which is a unique mobile system based on a robotic machinery technique that allows to automate all the constructive processes necessary for the execution of buildings and other civil works. The great innovations that differentiates Evo Constructor from any current alternative in the market are its unique cloned axis system, the economic and environmentally friendly characteristics and its self-climbing system, which translates into important cost and time savings.  Now, we already have the support of potential customers within the building sector. Nevertheless, we still need to carry out full operational test to validate our solution for its subsequent commercialization. Our market, the 3D Printing Construction Market, was valued at € 0.06bn in 2017, and it is estimated to grow with a CAGR of 78% reaching € 40bn by 2027. Based on our commercialization plan we will offer our solution mainly to construction companies of the building sector, but also architecture studies. It will include the sale and rent of Evo Constructor, but also maintenance and consultancy services. Following our business strategy, we establish an average price of € 0.82M per unit for sale, and € 287k for 6 months rental. Based on the profitability of the project we expect a cumulative revenue of € 22.4M by the third year, meaning a cumulative cash flow of € 13.1M. Considering a total investment of € 1.5M, we expect to get a ROI of 463% by 2022.
Graph convolutional neural networks for neutrino telescopes

While it is currently undergoing rapid developments, the neutrino sector still has many open questions: the neutrino mass
hierarchy is not known, several parameters of the PMNS matrix are poorly constrained, and the inability to explain the nonzero neutrino masses is a clear indication of physics beyond the Standard Model. Neutrino oscillation experiments at the
IceCube Neutrino Observatory may be able to address these fundamental questions, but the reconstruction of neutrino
interactions in the detector is a challenge which urgently needs to be addressed: the current reconstruction algorithm is
prohibitively time-consuming, cannot account for all known optical anisotropies in the ice, and cannot make full use of all of
the information from new modules in the IceCube Upgrade due to excessive computing time and memory requirements. This
project proposes graph convolutional neural networks (GCN) as a machine learning paradigm excellently suited for neutrino
telescope experiments, with potential to revolutionise reconstruction in IceCube. GCNs impose no structural requirements on
data, requiring only a concept of adjacency, naturally afforded by the spatial, temporal, and causal separation of hits in the
detector. With expected improvements in particle identification of a factor of 10 compared to analytical methods and a factor
10,000 speed-up in reconstruction, GCN-based reconstruction will be developed and implemented in the IceCube-DeepCore
oscillation analysis, to better measure PMNS parameters by improving the atmospheric muon background rejection and
performing per-flavour event categorisation. Powerful and fast GCN-based reconstruction will benefit several physics
analyses in IceCube --- and possibly ANTARES, KM3NeT, and Baikal-GVD --- and help answer the open questions in the
neutrino sector. Finally, the possibility for private and public sector partners to benefit from these high-performance GCN
tools will be explored through intersectional partnerships.
TARGETED DRUG DELIVERY AND THERAPEUTIC METHODS USING APO-E MODIFIED LIPID NANOPARTICLES

Methods for targeted delivery of therapeutic agents to a target cell or tissue with lipid nanoparticles comprising ApoE3. In embodiments, the invention specifically relates to targeted delivery of anticancer drugs, antibiotics, antifungal drugs, and diagnostic contrast agents, and associated treatment and diagnostic methods. In embodiments, diseases/conditions treated include those associated with over-expression of LDL receptors.