SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Generation of safe and efficient, off-the-shelf, chimeric antigen receptor (car)-engineered t cells for broad application

The feasibility and effectiveness of adoptive T cell therapies for cancer has now been proven in several clinical settings. Yet, the current approaches are still “individual-tailored” and thus, their progress and broader use is limited. Having rapid access to “off-the-shelf”, safe cellular products, which can be applied across histocompatibility limitations, would greatly benefit the broader applicability of adoptive T cell therapy. To this end, the applicant recently reported, in a proof-of-concept study, that genetic engineering of T-cell derived induced pluripotent stem cells (TiPSC) with Chimeric Antigen Receptors (CARs) can be an efficient strategy to concomitantly harness the unlimited availability of induced pluripotent stem cells and direct the specificity and functional potential of TiPSC-derived T cells in an HLA-independent manner. Based on this technology, this proposal aims to further investigate novel stem cell genetic engineering strategies in order to obtain in vitro, unlimited, safe and broadly applicable T cells targeting Multiple Myeloma (MM). We propose to target MM with a novel CD38-targeting CAR (CD38CAR). Since CD38 is not a MM-specific target, we aim to simultaneously tackle the on-target/off-tumor toxicity by introducing a drug-regulated expression of CD38CAR. In addition, we aim to use the CRISPR/Cas9 system to achieve targeted knockout of the endogenous T cell receptor (TCR) and the HLA antigens on the CAR-engineered TiPSCs (CARTiPSC) in order to extend the applicability of CARTiPSC-derived T cells across HLA-barriers. The success of this proposal will lay the foundation for further translational application of CARTiPSC-derived T cells cells and investigation of new strategies to enhance their effector function and persistence.
Promoting Sustainable Irrigation Management and non-conventional water use in the Mediterranean

In Mediterranean countries, water use for irrigation accounts for more than 70% of water consumption and an important hydric stress is registered due to increasing population and climate change. Water losses due to non-efficient irrigation systems, limited reliance on non-conventional water (NCW), scarce capacities of institutions to enforce effective water management plans and lack of awareness of modern solutions at farm level, are the most common issues to deal with. PROSIM will face these challenges focusing on both water demand and supply for irrigation. The project will bring innovative solutions combining water use efficiency and NCW and build local capacities to adopt/upscale them. Cross-border capacity building and roadmaps and plans for improved water management based on project results will be carried out while enhancing public-private cooperation will be fostered together with investments for the adoption/upscale of the proposed solutions.
Controlling Gold Nanoclusters by Diphospine Ligands

We report the synthesis and structure determination of a new Au22 nanocluster coordinated by six bidentate diphosphine ligands: 1,8-bis(diphenylphosphino) octane (L8 for short). Single crystal X-ray crystallography and electrospray ionization mass spectrometry show that the cluster assembly is neutral and can be formulated as Au22(L8)6. The Au22 core consists of two Au11 units clipped together by four L8 ligands, while the additional two ligands coordinate to each Au11 unit in a bidentate fashion. Eight gold atoms at the interface of the two Au11 units are not coordinated by any ligands. Four short gold–gold distances (2.64–2.65 Å) are observed at the interface of the two Au11 clusters as a result of the clamping force of the four clipping ligands and strong electronic interactions. The eight uncoordinated surface gold atoms in the Au22(L8)6 nanocluster are unprecedented in atom-precise gold nanoparticles and can be considered as potential in situ active sites for catalysis.
Electrostatic flocking method

An AC electrostatic flocking method having a variable frequency alternating electrostatic field that optimizes flocked product characteristics and/or processing efficiency. The optimized frequency can be determined on-line or from a chart or computerized database containing pre-determined optimized frequencies. The optimized frequency varies depending upon the precursors used and the processing conditions and parameters. Multiple in-line flocking modules having alternating variable frequency electrostatic fields operating at different frequencies may be utilized.
An open integration platform for professional displays

Airtame is a Start-up that carried out the highest funded European crowdfunding campaign of its time and received the “Best of CES 2014” award for the “Best Start-up” in 2014. Airtame launched a unique device for streaming digital content wirelessly which consists of a HDMI dongle that plugs into the HDMI port of any TV, projector or monitor and streams content from any device (PC, laptop, table or smartphone) to the screen.
Currently, the digital transformation of organizations (enterprises, schools, hospitals and public services) is changing the way people collaborate and communicate. This transformation has been triggering new practices such as Bring Your Own Device and Internal Digital Signage. However, the digitisation of organizations has raised new challenges, namely the creation of IT environments compliant with multi-devices and multi operating systems (OS: Android, iOS, Windows, MacOS, Chrome OS).
Building on our successful HDMI dongle, we are now developing an all-in-one platform (hardware and software) to deliver advanced tools and services inside of organizations, supporting smarter collaborative work and smarter corporate communication by using “big screens”. We offer the right technology, at the right time, in the emergence of audio-visual and ICT technologies that are changing organizations. However, to become a global leading provider of screen sharing solutions, we need to overcome barriers related with the maturation and demonstration of our cloud-based platform, aiming to create customers’ awareness and confidence in adopting our technology to accelerate market uptake. 
AirPlatform will be the only solution that is device/OS agnostic and can be used for both wireless presentations and smart digital signage at a very affordable price. With the successful achievement of this innovation project, we will boost our company’s growth, placing Airtame in a strong position, with expected revenues over five years exceeding €300 million.
Protection and RECOVERY of immaterial CULTUural heritage of Central Europe through Ecomuseums, as driver of local growth

CEU is rich in a variety of cultural tangible & intangible phenomena, many of which are inscribed in national or UNESCO heritage lists but lack of sustainable preservation & management. CULTRECOVERY deals with immaterial cultural heritage as result of interrelation between populations & territories, precious source of traditions, artefacts, typical products. Despite its recognized importance such heritage is often underestimated risking to be lost.
Eco-museums represent a great potential, focusing on the identity of a place, largely based on local participation, stimulating the dialogue on issues related to management of conflicting usage interests, preservation & enhancement for economic, social, cultural activities.
Project aims at improving Ecomuseums’ managers’ & operators’ capacities, promoting proper strategies & action plans for the preservation & valorization of immaterial cultural heritage and  new solutions for a wider qualitative & quantitative offer of the territories.
Exp. changes:
- Improvement of management models of ecomuseums and of operators’ capacities, from “traditional/standard” models into innovative performing ones, with a tighter public-private cooperation
- Increase of qualitative & quantitative offer allowing a wide and quality enjoyment of the immaterial cultural heritage through innovative solutions to “tell about identities” & “get through” the targets.
 A holistic & bottom-up approach to culture, tackling issues in an integrated & interdisciplinary way, focusing on the involvement of communities. This approach needs a mix of complex competences & human resources, difficult to put together for a single territory. Transn. coop. is therefore needed.
Innovation lies in community based care for heritage, promoting tourism by reactivating forgotten potentials.
Communities will receive new tools & skills to create their job opportunities & reinterpret heritage with a long term develop. vision
Adapting Enzyme-Free DNA Circuits to the Detection of Loop-Mediated Isothermal Amplification Reactions

Loop-mediated isothermal amplification of DNA (LAMP) is a powerful isothermal nucleic acid amplification technique that can accumulate ~10(9) copies from less than 10 copies of input template within an hour or two. Unfortunately, while the amplification reactions are extremely powerful, the quantitative detection of LAMP products is still analytically difficult. In this article, to both improve the specificity of LAMP detection and to make direct readout of LAMP amplification simpler and much more reliable, we have developed a nonenzymatic nucleic acid circuit (catalyzed hairpin assembly, CHA) that can both amplify and integrate the specific sequence signals present in LAMP amplicons. Through a hairpin acceptor, one of the four loop products amplified from the LAMP is transduced to an active catalyst ssDNA which can in turn trigger a CHA reaction. After CHA detection, even less than 10 molecules/μL model templates (M13mp18) can produce significant signal, and both nonspecific template and parasitic amplicons cannot bring interference at all. More importantly, to further enhance the specificity, we have designed a dual-CHA circuit that only gave positive responses in presence of two LAMP loops. The AND-GATE detector will act as a simultaneous, specific readout of the LAMP product, rather than of competing and parasitic amplicons.
TWO DIMENSIONAL POLYAMIDES PREPARED FROM UNSATURATED CARBOXYLIC ACIDS AND AMINES

A polyamide and a process for preparing the polyamide are disclosed. The process comprises reacting in a reaction mixture a monomer selected from unsaturated carboxylic acids, esters of unsaturated carboxylic acids, anhydrides of unsaturated carboxylic acids, and mixtures thereof, and a first amine to form an intermediate reaction product in the reaction mixture, wherein the first amine is selected from RR1NH, RNH2, RR1NH2<+>, RNH3<+> and mixtures thereof, wherein R and R1 can be the same or different and each contain between about 1 and 50 carbon atoms and are optionally substituted with heteroatoms oxygen, nitrogen, sulfur, and phosphorus and combinations thereof, and reacting the intermediate reaction product an a second amine to form a polyamide, wherein the second amine is selected from R2R3NH, R2NH2, R2R3NH2<+>, R2NH3<+> and mixtures thereof, wherein R2 and R3 can be the same or different and each contain between about 1 and 50 carbon atoms and are optionally substituted with heteroatoms oxygen, nitrogen, sulfur, and phosphorus and combinations thereof, wherein multiple of the R, R1, R2, and R3 are in vertically aligned spaced relationship along a backbone formed by the polyamide. In one version of the invention, the first amine is an alkylamine, such as tetradecylamine, and the second amine is a polyalkylene polyamine, such as pentaethylenehexamine. In yet another version of the invention, the first amine and the second amine are olefinic or acetylenic amines, such as the reaction products of an alkyldiamine and an acetylenic carboxylic acid. The first amine and the second amine may be the same or different depending on the desired polyamide polymer structure.
Tradition et modernité du pastoralisme : reconnaissance de ses multiples rôles dans le développement durable des territoires méditerranéens

Stock-rearing farms carry out many functions in territorial development. They play a direct economic role by maintaining jobs and services in difficult areas and supplying consumers with quality agricultural products. Cattle play a role in the management of natural areas stretching from coasts to highmountain transhumance areas, and the surface areas involved account for hundreds of thousands of hectares in each of the regions involved. After the impact of the Structural Funds on territories in southern Europe, it is now important to monitor trends, to share experiences and to ensure that they are recognised by all those involved in both farming and non-farming activities in order to improve the efficiency of community, national and/or regional policies. Overall objective / Objectif général Pastomed 1 aims to promote knowledge and recognition of the role of stock rearing in the sustainable development of Mediterranean territories. The operation covers disadvantaged or mountainous areas that are underpopulated and suffer from major economic handicaps. They are all, therefore, Objective 1 and Objective 2 regions for Structural Funds. The new working methods planned bring together different types of territorial partners so that they can establish technical and economic strategies and propose improvements for policies and public action. Expected results / Résultats attendus Pastomed 1 aims to promote knowledge and recognition of the role of stock rearing in the sustainable development of Mediterranean territories. The operation covers disadvantaged or mountainous areas that are underpopulated and suffer from major economic handicaps. They are all, therefore, Objective 1 and Objective 2 regions for Structural Funds. The new working methods planned bring together different types of territorial partners so that they can establish technical and economic strategies and propose improvements for policies and public action.
A web-based intervention for abused women: the New Zealand isafe randomised controlled trial protocol

Intimate partner violence (IPV) and its associated negative mental health consequences are significant for women in New Zealand and internationally. One of the most widely recommended interventions is safety planning. However, few women experiencing violence access specialist services for safety planning. A safety decision aid, weighing the dangers of leaving or staying in an abusive relationship, gives women the opportunity to prioritise, plan and take action to increase safety for themselves and their children. This randomised controlled trial is testing the effectiveness of an innovative, interactive web-based safety decision aid. The trial is an international collaborative concurrent replication of a USA trial (IRIS study NCT01312103), regionalised for the Aotearoa New Zealand culture and offers fully automated online trial recruitment, eligibility screening and consent.In a fully automated web-based trial (isafe) 340 abused women will be randomly assigned in equal numbers to a safety decision aid intervention or usual safety planning control website. Intervention components include: (a) safety priority setting, (b) danger assessment and (c) an individually tailored safety action plan. Self-reported outcome measures are collected at baseline and 3, 6, and 12-months post-baseline. Primary outcomes are depression (measured by Center for Epidemiologic Studies Depression Scale, Revised) and IPV exposure (measured by Severity Violence Against Women Scale) at 12 months post-baseline. Secondary outcomes include PTSD, psychological abuse, decisional conflict, safety behaviors and danger in the relationship.This trial will provide much-needed information on the potential relationships among safety planning, improved mental health, reduced violence as well as decreased decisional conflict related to safety in the abusive relationship. The novel web-based safety decision aid intervention may provide a cost-effective, easily accessed safety-planning resource that can be translated into clinical and community practice by multiple health disciplines and advocates. The trial will also provide information about how women in abusive relationships safely access safety information and resources through the Internet. Finally, the trial will inform other research teams on the feasibility and acceptability of fully automated recruitment, eligibility screening, consent and retention procedures.Trial registered on 03 July 2012 on the Australian New Zealand Clinical Trials Registry ACTRN12612000708853 .
Despliegue de la función calidad para determinar los requisitos de diseño en biopilas experimentales a escala de banco, evaluadas como alternativa resiliente para la degradación de residuos petrolizados

Debido al aumento en la cantidad de petrÃ³leo utilizado, grandes cantidades de hidrocarburos se liberan anualmente al medio ambiente, constituyendo una de las principales causas de contaminaciÃ³n del suelo a nivel mundial. El Centro de Estudios Ambientales de Cienfuegos, Cuba, ejecutÃ³ un proyecto experimental para desarrollar una tÃ©cnica innovadora que aumentase la resiliencia territorial, ante dicho problema ambiental. El objetivo fue implementar el Despliegue de la FunciÃ³n Calidad (QFD), para determinar los requisitos de diseÃ±o de las unidades experimentales a evaluar a escala de banco, durante la degradaciÃ³n de residuos petrolizados mediante diferentes tratamientos de la ecotecnologÃ­a de biopilas. Se implementÃ³ un enfoque de 4 etapas que permitiÃ³ organizar el equipo, seleccionar la tecnologÃ­a, adoptar un procedimiento para la implementaciÃ³n del QFD para traducir las necesidades en requisitos de ingenierÃ­a y diseminar los resultados. Las concentraciones de microorganismos, nutrientes y de hidrocarburos en la biopila, fueron las caracterÃ­sticas que acumularon mÃ¡s del 50% de los pesos relativos de la matriz de primer nivel. ConcentraciÃ³n inicial de hidrocarburos y los porcentajes de humedad y de texturizantes en la mezcla, obtuvieron los mayores pesos relativos en el segundo nivel. El porcentaje de texturizantes en la mezcla de la biopila se identificÃ³ como una oportunidad de reducir los costos y de mejorÃ­a en la eficacia de la biorremediaciÃ³n. Los resultados y lecciones aprendidas propiciaron delinear los protocolos experimentales para el diseÃ±o ingeniero y permitieron construir un prototipo a escala de banco de las biopilas experimentales para la evaluaciÃ³n de diversos tratamientos.
Enhanced sea-air CO2exchange influenced by a tropical depression in the South China Sea

Ship measurements made 2 days after the passage of a tropical depression (TD) in the South China Sea (SCS, April 2011) showed two contrasted responses of the partial pressure of CO2 at sea surface (pCO2,sw). In low sea-surface salinity (SSS) water, pCO2,sw was low (349 ± 7 μatm), and the area was a carbon sink (−4.7 ± 1.8 mmol CO2 m−2 d−1), whereas in water with high SSS and chlorophyll a and low dissolved oxygen and sea surface temperature, pCO2,sw was higher than for normal SCS water (376 ± 8 versus 362 ± 4 μatm) and the area was a carbon source (1.2 ± 3.1 mmol CO2 m−2 d−1). Satellite data showed two large areas of low SSS before the TD, which were likely influenced by rainfall, and these areas were considered to have low pCO2,sw because of their low SSS. The high pCO2,sw after the TD is explained by the uplifting to the surface of deeper and CO2-rich water, due to winds accompanied by the TD. The difference in sea-air CO2 flux between the TD-affected area and the lower-SSS water was 1.99 + 4.70 = 6.7 mmol CO2 m−2 d−1, indicating a 100% change caused by the TD compared to the average seasonal value in spring in southern SCS (3.3 ± 0.3 mmol CO2 m−2 d−1). Undersaturation of CO2 prior to the TD due to dilution by freshwater and the preexisting cold eddy, and slow translation speed of the TD, are considered to account for the CO2 flux change.
Factory automation edge computing operating system reference implementation

Despite the proclaimed benefits (i.e. scalability, reliability, cost-effectiveness) of Future Internet (FI) technologies (i.e. edge & cloud computing, IoT/CPS) for factory automation, their adoption from manufacturers remains low for various reasons, including technology issues (e.g., poor situation awareness, limited deployments, no standards-based reference implementations) and the lack of a smooth migration path from legacy systems.
FAR-EDGE is a joint effort of leading experts in manufacturing, industrial automation and FI technologies towards the smooth and wider adoption of virtualized factory automation solutions based on FI technologies. It will research a novel factory automation platform based on edge computing architectures and IoT/CPS technologies.  FAR-EDGE will provide a reference implementation of emerging standards-based solutions for industrial automation (RAMI 4.0, Industrial Internet Consortium reference architecture), along with simulation services for validating automation architectures and production scheduling scenarios. FAR-EDGE will lower the barriers for manufacturers to move towards Industrie 4.0, as a means of facilitating mass-customization and reshoring. Emphasis will be paid in the study of migration options from legacy centralized architectures, to emerging FAR-EDGE based ones.
FAR-EDGE will be validated in real-life plants (VOLVO, WHIRLPOOL) in the scope of user-driven scenarios (business-cases) for mass-customization and reshoring, where tangible improvements relating to reliability, productivity increase, quality cost, reduction in adaptation effort/costs will be measured and evaluated. Also, a wide range of migration scenarios will be evaluated in the scope of a CPS manufacturing testbed.
FAR-EDGE will also establish a unique ecosystem for FI factory automation solutions, which will bring together the FoF and FI communities (e.g., EFFRA, Industrie 4.0, AIOTI, ARTEMIS JU) and will ensure sustainability of FAR-EDGE results.
Effect of lipopolysaccharide on the production of prostaglandin E2 and inhibition of uterine contractions by nitric oxide in pregnant inducible nitric oxide synthase knockout mice

The aim of the present study was to evaluate the effect of lipopolysaccharide (LPS) on the production of prostaglandin E2 (PGE2) and inhibition by nitric oxide (NO) of spontaneous contractions of uterine rings from pregnant inducible isoform of nitric oxide synthase knockout (iNOS KO) mice.iNOS KO and wild-type mice were sacrificed 6 h after intraperitoneal (i.p.) administration of LPS on day 14 of gestation. Uterine rings were equilibrated in Krebs-Henseleit solution for isometric tension recording. In part of the uterine rings, placental tissues were left attached. The bathing solution was analyzed for PGE2 by radioimmunoassay. Changes in spontaneous contractions in response to cumulative concentrations of L-arginine, diethylamine/nitric oxide (DEA/NO), and 8-bromo-cyclic guanosine monophosphate (8-br-cGMP) were determined.Treatment with LPS increased PGE2 production by uterine rings from wild-type and iNOS-KO mice. DEA/NO and 8-br-cGMP inhibited spontaneous contractions in uterine rings in the absence or presence of placenta, in both LPS-treated and LPS-untreated animals. LPS treatment attenuated maximal inhibition induced by the agents, both in the absence and presence of placental tissues in iNOS KO and wild-type mice.LPS induces PG production in mice myometrium that is not dependent on the integrity of iNOS, while LPS could induce pathophysiological iNOS obstruct uterine quiescence by physiological iNOS. Infection affects uterine contractile activity through PG production, as well as through placental and genetic factors. NO may be a double-edged sword in pregnant mice myometrium.