SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Defining the immunosuppressive milieu of prostate cancer with single cell omics technologies

The immune contexture of prostate cancer is poorly studied, despite among researchers there is a strong interest in developing immunotherapy approaches to cure the disease. It is known that the immune system can have a dual role in the tumor progression, in other words, it can either promote or suppress tumor growth and invasion. However, the immunomodulation of prostate cancer and the immunosuppressive mechanisms involved are still not entirely known. In this proposal, I suggest using and integrating Omics data from various sources to give a holistic and comprehensive overview of the immune milieu of prostate cancer at a single cell level. Human prostate cancer samples will be used to generate transcriptomics with scRNA-Seq, epigenomics with scATAC-Seq and multiplexed images with the Hyperion system. Transcriptomics and epigenomics data at the single cell level will allow the classification of the cell types at the molecular level, the delineation of related biomarkers and biological mechanisms as well as the establishment of a prostate cancer specific deconvolution approach. Spatial information will be obtained for candidate biomarkers found through scRNA-Seq and scATA-Seq, and all data will be then integrated in order to create a link between transcriptional regulation, signaling pathways and cell-cell interaction. High throughput data integration in prostate cancer will allow elucidation of the biological mechanisms involved in an unprecedented level. This study will be a powerful resource for future basic studies on prostate cancer, but also for guiding the development of novel immunotherapy approaches.
Non-Archimedean mirror symmetry

Mirror symmetry is one of the most mysterious dualities in mathematics. Roughly, it predicts that given any Calabi-Yau variety, there exists a mirror Calabi-Yau variety such that a rich list of geometric relations hold between the two, involving Hodge numbers, Gromov-Witten invariants, variation of Hodge structures, Floer homology (Fukaya category), coherent sheaves, stability conditions and so on. Despite continual progress in the subject, a fundamental question remains unclear: to what extent do mirrors exist, and how to construct the mirror variety?

Here we propose a new approach to answer this question, based on latest developments from non-archimedean geometry, in particular the theory of Berkovich spaces, as well as derived non-archimedean geometry. Our goal is to conceive and pursue a full-fledged theory of non-archimedean mirror symmetry, which will lead to new results unattainable from existing methods.

We propose to work out a general mirror construction, starting directly from a non-archimedean Strominger-Yau-Zaslow torus fibration, conjectured by Kontsevich-Soibelman, by counting non-archimedean analytic disks with boundaries on SYZ torus fibers. First we need to establish the existence of such counts in full generality, based on non-archimedean Gromov-Witten theory and tail conditions. Then we have to prove various properties of the mirror algebra, including associativity, radius of convergence and singularity estimates. Finally we propose to use wall-crossing formulas to glue local mirror algebras together to obtain the global mirror variety. A long-term goal is to show that the mirror construction is an involution, the best exhibition of mirror duality.

We also aim for applications outside mirror symmetry, in particular towards the moduli of KSBA stable pairs in birational geometry. Our project is intimately related to the ongoing Gross-Siebert program based on logarithmic geometry. We also expect fruitful future interactions with their program.
Innovation and CHange: Network of One-stop Shops for Business - PLUS

The project ICHNOS PLUS aims to build on the achievements of the Interreg III C project entitled "ICHNOS: Innovation and CHange – Network of One-Stop Shops”, concluded in April 2007, that produced a model of Regional Centre of Competence (RCC) for One-Stop Shops for business (OSS).
As a capitalisation project, ICHNOS PLUS focuses on the transfer and deployment of the RCC model and its mainstreaming into the regional policies through the ERDF Operational Programmes. The RCC model has been conceived as a structure to co-ordinate OSS acting as single points of contact for enterprises. Altough the establishment of OSS is foreseen by the EU legislation and was expected in all Member States by 2007, most regions have not accomplished yet with this task.
The partnership is made of 6 partners: Ancitel Sardegna (Italy); CESGA - Galicia (Spain), Vysocina Region (Czech Republic), North Aegean Region (Greece), S&T Park of Tartu (Estonia) and Ruda Slaska Business Incubator (Poland).
The main activities envisaged to achieve these goals are: 
• Studies and surveys. Extension to the new partner regions of an analysis carried out under ICHNOS, aimed to highlight and compare the main features that influence starting or running a business in the regions involved; a toolkit of the upgraded RCC and a feasibility study for a tailor-made transfer of the RCC model.
• Regional meetings aimed at involving Managing Authorities and local stakeholders in the project activities by concertating the actions to be undertaken and collecting the feedbacks of the steps taken.
• On-site visits and staff exchanges designed to build capacity, raise awareness and improve know-how in the participating regions. 
• Interregional seminars to make available all the information and material on the concerned practices; to raise awareness on the ICT solutions for easing start-ups, and a joint training session to deepen specific issues of partners’ interest.
• Dissemination activities.
The main outputs will be:
1 Report of the context analysis carried out in the six partner Regions; 1 Toolkit of the upgraded model of Regional Centre of Competence; 3 Interregional thematic and training seminars on the main issues of relevance for the project; 4 On site visits; 4 Staff exchanges; 6 Feasibility studies (1 per region) for a tailor-made transfer and implementation of the practices; 6 Action Plans (1 per region) describing how the RCC model and the other good practices will be implemented under the Regional OP; 1 Website; 7 brochures; 8 Newsletters; 24 Articles; 3 International dissemination Conferences.

The expected results are:
5 good practices transferred; 6 regional policies influenced in terms of simplification of administrative procedures for start-ups; 60 regional key actors mentored in the way the RCC model works; 30 staff practitioners increased competences about the services delivered by the OSS and RCC; 200 stakeholders’ raised awareness.
Leveraging Cluster Policies for successful implementation of RIS3

Through cooperation, SMEs address the challenge of dimension which enables them to achieve global competitiveness, sustainable growth and development. Cooperation among SMEs, large companies and the Regional Innovation system within a given cluster or cross-cluster, it is a major driver to enhance innovation and internationalisation capabilities. Being the cluster organisations the major facilitators for cooperation among SMEs, and due to their multiplier effect, the target of the project is to improve cluster policies and the performance of cluster organisations; having in mind their important role in the insertion of SMEs in global value chains and in leveraging the successful implementation of RIS3. CLUST&RIS3 aims to share baseline information on cluster policy learning in 4 years journey based on a strong multidisciplinary partnership representing different realities and innovation systems (9 partners, 7 EU regions). During the 1st phase we will focus on the exchange of experiences to identify and transfer good practices, being policy learning events and peer review the most relevant. During the 2nd phase, on the monitoring of the Action Plan implementation in all partner regions. We expect to achieve: 30 practices assessed; 15 good practices identified; 3Joint Policy Documents produced; 9 Policy learning events, resulting in 100 people with increased professional capacities. On the regional level we expect to strengthen the innovation and competitiveness ‘enablers’; a better alignment of clusters, policies and projects with RIS3; overcome the disadvantage of SMEs dimension and make regional procedures and programmes more cluster-friendly. All in all, to share joint policy tools such as monitoring & evaluation to follow up the achievements and progress of clusters and policy effectiveness. This will allow them to benchmark, identify best performers and learn by comparison over the years and thus, leverage Cluster Policies for successful implementation of RIS3.
Manipulation Capabilities with Simple Hands

A simple hand is a robotic gripper that trades off generality in function for practicality in design and control. The long-term goal of our work is to explore that tradeoff and demonstrate broad manipulation capabilities with simple hands. This paper describes two prototype simple hands. Both hands have thin cylindrical fingers arranged symmetrically around a low friction circular palm. The fingers are compliantly coupled to a single actuator. Our experiments with both hands in a bin-picking scenario demonstrate that we can achieve robust grasp classification and in-hand localization using simple statistical techniques. We further show how the classification accuracy increases as the grasp proceeds by exploiting information obtained online. We finally evaluate the relative importance of observing the full state of the hand rather than just observing the state of the actuators.KeywordsRobotic HandRobot Operating SystemGrasp StabilityGrasp MotionSimple HandThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
Deciphering the molecular dynamics of centriole and centrosome biogenesis

Centrosomes are organelles composed of a pair of centrioles surrounded by a pericentriolar matrix (PCM) that perform a variety of key functions in the animal cell. Centrosomes duplicate precisely once during S-phase of the cell cycle; in G2-phase the two centrosomes move to opposite locations around the nucleus and expand their PCM to nucleate vast quantities of microtubules for mitotic spindle formation. Dysfunctions in the centrosome cycle have been associated with a wide range of pathologies and, in particular, centrosome amplification, an aberrant increase in centrosome numbers, is a hallmark of most human cancers. Centrosomes are complex machines composed of hundreds of proteins, however significant efforts over the past decades have identified the key elements which are essential for centriole and centrosome biogenesis. We can now address the molecular mechanisms that mediate interactions between key players and how these contribute to regulate the number and size of these organelles during the cell cycle. Elucidating these mechanisms is of great interest to cell biology and cancer research. This research proposal aims to investigate aspects of centriole and centrosome biogenesis using Drosophila melanogaster as an animal model. The main objectives are: 1), to reconstitute initial steps of centriole assembly using a hybrid in vivo/in vitro approach, where I will study the molecular dynamics of the interaction between key centriolar proteins Asl and Plk4, using functionalised microspheres as a scaffold and 2), to analyse the dynamic behaviour of single molecules of key centrosomal proteins Cnn and Spd-2 as they move throughout the PCM during expansion, using super-resolution microscopy techniques. We are confident that these studies will provide novel insights into the design principles and inner workings of these important organelles.
European endeavour for chimeric antigen receptor therapies

Cancer is rapidly becoming the most frequent cause of death in EU. Though enormously expensive (several billions EUR/year), currently available anti-cancer therapies are major causes of chronic diseases. Adoptive immunotherapy with T cells genetically modified with a tumour-reactive chimeric antigen receptor (CAR) is an innovative therapeutic concept, promising to eradicate cancer without causing secondary chronic diseases. This approach is already at an advanced stage of development in the US, but struggles in the EU, due to a number of constrains that will be specifically tackled by this Project. The ultimate goal of EURE-CART is to bring EU at the forefront CAR T-cell immunotherapy. In this Project, we will extend the applicability of CAR T-cell immunotherapy to incurable tumours that have never been tackled with this approach. The EURE-CART Consortium is composed of 6 academic centres, 2 SMEs and 1 large enterprise from 6 EU countries, clearly representing excellences in their respective fields. EURE-CART will bring together clinical experts in oncology, and pioneers and leaders in the field of cell and gene therapy for conducting a first-in-man Phase I/II clinical trial. To be successful, EURE-CART proposes the early involvement of National regulatory authorities for accelerating the approval of CAR T-cell immunotherapy, as well as the centralisation of its production by the Molmed Spa. Molmed Spa is uniquely endowed in the EU with the know-how and experience necessary to meet this ambitious objective, as demonstrated by its unparalleled track record. The main expected impact of EURE-CART is the establishment of CAR T-cell therapy as the ultimate personalised therapy, capable of defeating chronic diseases, and to create secure new jobs in the EU through the instalment of an unprecedented alliance between academia, industry and regulatory bodies.
Simple and selective analysis of different antibiotics in milk using molecularly imprinted polymers: a review

The frequent, sometimes illegal, use of antibiotics for therapeutic and prophylactic purposes in dairy cattle management may cause residues in milk. Because of problems concerning bacterial resistance or allergies in consumers, monitoring of residues is required. In spite of the huge development of analytical instrumentation during recent years, sample preparation is still a bottleneck of the analytical process. In this regard, efforts have been directed towards improving selectivity during extraction and clean-up of samples. Compared to traditional sorbents, molecularly imprinted polymers (MIPs) are excellent materials to provide selectivity for sample pretreatment. This review presents the application of MIPs as effective sorbents for separation, clean-up, pre-concentration and analysis of different antibiotics in milk.
Scheme for improved integration and lifetime for piezoelectric energy harvesters

The power output of piezo harvesters can be significantly increased by using charge modification techniques such as piezoelectric pre-biasing or synchronous switched harvesting, but in order to achieve a significant power gain high Q electrical resonant circuits must be used. For integrated systems with a significant size constraint, or in systems using on-chip inductors, achieving high Q can be difficult. Here we present an improved interface circuit which performs better than all previously presented techniques, especially in cases where the Q-factor of the resonant circuit is low. This has the added advantage of extending the useful life of the harvester because repeated cycling reduces the quality of the piezoelectric film, increasing the series resistance and lowering the electrical Q and the performance. Maximum power extraction by this new circuit is also less sensitive to the supply rail voltage than previously presented implementations, which reduces control power overhead.
Sinopse de Malpighiaceae no município de Cunha corrobora a ocorrência de fragmentos de Cerrado no Vale do Paraíba, Estado de São Paulo, Brasil.

RESUMO Estudos de campo e a análise de coleções de herbários permitiram a identificação de dez gêneros e 19 espécies de Malpighiaceae no município de Cunha, Estado de São Paulo, Brasil. Este trabalho apresenta uma chave de identificação para espécies, listas de materiais examinados, notas taxonômicas e imagens fotográficas das espécies estudadas. Este estudo apresenta ainda a primeira ocorrência de Stigmaphyllon acuminatum para o Estado de São Paulo. Adicionalmente, apresentamos uma discussão sobre as evidências provenientes de Malpighiaceae que corroboram a ocorrência pretérita e presente de fragmentos de cerrado no vale do rio Paraíba.
Where does heterogeneity exist in ventricular tachyarrhythmias?

Reentry is the most common mechanism for tachyarrhythmias including lethal ventricular tachycardia observed in patients with structural heart diseases, such as an old myocardial or dilated cardiomyopathy. In contrast, torsades de pointes (TdP) is a polymorphic ventricular tachycardia often associated with QT prolongation in patients with long QT syndrome. There is general agreement that the initiating premature ventricular beat (PVB) leading to TdP is due to early afterdepolarization–induced triggered activity; however, the subsequent polymorphic ventricular beats are due to a reentrant mechanism. It is well known that electrical heterogeneity of the action potential duration (APD) or refractoriness is required to establish reentrant arrhythmias. One of the important heterogeneous factors of ventricular repolarization for ventricular tachyarrhythmias is that located across the ventricular wall (ie, transmural heterogeneity). Numerous studies over these past 20 years have mainly highlighted the transmural heterogeneity involved in the response of diverse cell types to pharmacological agents and pathophysiological states. The 3 cell types making up the ventricular wall are epicardial, mid-myocardial (M), and endocardial cells, and they differ principally with respect to their repolarization characteristics. M cells are distinguished by the ability of their action potential to prolong more than those of epicardial and endocardial cells in response to a slowing of the rate and/or in response to drugs with APD/QT prolonging actions, such as fast activating delayed rectifier potassium current blockers or late sodium current (INa-L) enhancers. The ionic basis for these features includes the presence of a smaller slowly activating delayed rectifier potassium current, larger INa-L, 10 and larger electrogenic sodium-calcium exchange current (INa-Ca) 11 in the M region compared with those in the epicardial or endocardial cells. The significant contribution of an enhanced transmural heterogeneity has been reported in experimental models of congenital long QT syndrome employing an arterially perfused canine ventricular wedge preparation. We
ASSEMBLING DEVICE

The invention concerns an assembling device (10) in particular for mutually connecting together two bars (12, 14), which have at an assembly point two substantially complementary profiled sections, one positive and one negative. Said profiled sections are set in assembling position along a parting line (22), taking into account a given degree of freedom, a separate safety lock (24) extending on either side of the parting line (22) between the positive profiled section and the negative profiled section. The bars (12, 14) associated with the safety lock (24) form an assembly consisting of three elements, between which a mobility locking is formed by the safety lock (24) in the direction opposite to the direction of the degree of freedom, immediately prior to assembly positioning. When the assembly is carried out, the lines of the positive and negative profiled sections form a recess corresponding to a transverse profiled section of the safety lock (24), said recess being covered on both sides by the parting line (22).
Introducción a la oferta de un servicio mejorado y un nuevo producto innovador — con el fin de aumentar la competitividad de la empresa en una situación pandémica

Como parte de este proyecto, se planea la compra de activos fijos con el fin de introducir un nuevo producto en la empresa y un servicio mejorado en el campo del mecanizado mecánico de elementos metálicos. Como parte del proyecto, se planea lanzar un producto completamente nuevo, propietario — máquina expendedora (máquina expendedora totalmente automatizada en cápsulas). La implementación del proyecto aumentará la competitividad, contribuirá a la creación de nuevos puestos de trabajo por parte de la empresa y permitirá adaptarse a las realidades del mercado relacionadas, entre otras, con la crisis de salud pública causada por la propagación del coronovirus humano SARS-COVID-19. La implementación de este proyecto es una medida necesaria para combatir las consecuencias de la situación pandémica en relación con la empresa y la economía del Voivodato Silesiano.
Cultural HEritagE. Risks and Securing activities

The Alps host an outstanding variety of material and immaterial cultural heritage which are the grounds of Alpine peoples identity and strongly contribute to the local economies. Natural disasters, affecting the Alpine territory and prone to be exacerbated by the climate change, represent a major threat to cultural heritage, in terms of asset safety and fruition. Risk assessment and disaster reduction & management have drawn a growing attention by policy makers at EU and Alpine level mainly focusing on the protection of human lives and infrastructures. Yet, the safeguard of cultural heritage from natural hazards has not been properly tackled. Alpine local communities often lack appropriate regulatory settings, know-how and operational capacities to manage securing activities of their cultural resources. The project focus on this gap and aims at supporting relevant transnational and local organizations in the valorization of cultural heritage by (A) promoting new national and transnational governance and intervention schemes involving the main actors engaged in the management and protection of cultural heritage and (B) providing innovative approaches and tools to secure and salvage cultural assets affected by natural risks. These goals will be achieved through: 1) building the knowledge base for identifying and valorising the cultural heritage stock at risk; 2) defining reference conservation/securing approaches, techniques and training for Civil Protection Operators; 3) developing new models of emergency planning to protect cultural heritage, built on shared pilot experience and transferable at transnational level; 4) capitalizing innovation technologies for effective and more comprehensive DDR and climate change adaptation policies. The project is consistent and cooperative with the ongoing EU policies, the EUSALP Action Plan and the Alpine Convention strategies in the field of valorization of cultural resources and their protection from natural risks.