SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Protein Interactions and Localization of the Escherichia coli Accessory Protein HypA during Nickel Insertion to [NiFe] Hydrogenase

Nickel delivery during maturation of Escherichia coli [NiFe] hydrogenase 3 includes the accessory proteins HypA, HypB, and SlyD. Although the isolated proteins have been characterized, little is known about how they interact with each other and the hydrogenase 3 large subunit, HycE. In this study the complexes of HypA and HycE were investigated after modification with the Strep-tag II. Multiprotein complexes containing HypA, HypB, SlyD, and HycE were observed, consistent with the assembly of a single nickel insertion cluster. An interaction between HypA and HycE did not require the other nickel insertion proteins, but HypB was not found with the large subunit in the absence of HypA. The HypA-HycE complex was not detected in the absence of the HypC or HypD proteins, involved in the preceding iron insertion step, and this interaction is enhanced by nickel brought into the cell by the NikABCDE membrane transporter. Furthermore, without the hydrogenase 1, 2, and 3 large subunits, complexes between HypA, HypB, and SlyD were observed. These results support the hypothesis that HypA acts as a scaffold for assembly of the nickel insertion proteins with the hydrogenase precursor protein after delivery of the iron center. At different stages of the hydrogenase maturation process, HypA was observed at or near the cell membrane by using fluorescence confocal microscopy, as was HycE, suggesting membrane localization of the nickel insertion event.
USES AND COMPOSITIONS FOR TREATMENT OF CROHN'S DISEASE

The invention provides methods, uses and compositions for the treatment of Crohn's disease. The invention describes methods and uses for treating Crohn's disease, wherein a TNFcc inhibitor, such as a human TNF oc antibody, or antigen-binding portion thereof, is used to induce and maintain remission of Crohn's disease in a subject. Also described are methods for determining the efficacy of a TNFa inhibitor for treatment of Crohn's disease in a subject.
Characterization of Soymilk Prepared by Milling and Pressing at High Temperature

The effect of milling and pressing soybeans at high temperatures (50–90C) was examined for laboratory-scale soymilk preparation. Soymilk that was milled and pressed at high temperatures showed more precipitate and a slightly lower protein content. The surface sulfhydryl content and surface hydrophobicity of the soymilk protein increased with milling temperature, which indicates some acceleration of the thermal denaturation of proteins. Ultracentrifugation and laser diffraction particle size analysis of the soymilk showed that milling at 90C resulted in highly dispersed protein aggregates and emulsions.

Practical Applications
Processing method for soymilk was improved to decrease beany flavor derived from lipoxygenase. Now soybean is milled at high temperatures to inactivate lipoxygenase activity, but there are no useful data on the quality of the resulting soymilk. In this study, milling at 90C showed more disperse soymilk than at 80C by considering droplet size distribution and protein denaturation behavior. These data are useful for estimation of the quality of soymilk beverage and for improvement of soymilk processing for more palatable beverages.
The Single-Molecule Mechanics of the Latent TGF-β1 Complex

<h2>Summary</h2><h3>Background</h3> TGF-β1 controls many pathophysiological processes including tissue homeostasis, fibrosis, and cancer progression. Together with its latency-associated peptide (LAP), TGF-β1 binds to the latent TGF-β1-binding protein-1 (LTBP-1), which is part of the extracellular matrix (ECM). Transmission of cell force via integrins is one major mechanism to activate latent TGF-β1 from ECM stores. Latent TGF-β1 mechanical activation is more efficient with higher cell forces and ECM stiffening. However, little is known about the molecular events involved in this mechanical activation mechanism. <h3>Results</h3> By using single-molecule force spectroscopy and magnetic microbeads, we analyzed how forces exerted on the LAP lead to conformational changes in the latent complex that can ultimately result in TGF-β1 release. We demonstrate the unfolding of two LAP key domains for mechanical TGF-β1 activation: the α1 helix and the latency lasso, which together have been referred to as the "straitjacket" that keeps TGF-β1 associated with LAP. The simultaneous unfolding of both domains, leading to full opening of the straitjacket at a force of ∼40 pN, was achieved only when TGF-β1 was bound to the LTBP-1 in the ECM. <h3>Conclusions</h3> Our results directly demonstrate opening of the TGF-β1 straitjacket by application of mechanical force in the order of magnitude of what can be transmitted by single integrins. For this mechanism to be in place, binding of latent TGF-β1 to LTBP-1 is mandatory. Interfering with mechanical activation of latent TGF-β1 by reducing integrin affinity, cell contractility, and binding of latent TGF-β1 to the ECM provides new possibilities to therapeutically modulate TGF-β1 actions.
METHOD AND DEVICE FOR MONITORING OPERATION OF A MINING MACHINE UNIT

The present invention pertains to a method for monitoring operation of a mining machine unit (30), particularly of a longwall mining system (10), having a shield unit (32) connected to a material removing unit (12) by means of an actuator (36) for adjusting a distance between the shield unit (32) and the material removing unit (12), the method comprises the steps of determining a position change of the shield unit (32) during an actuating operation of the actuator (36); and a step of detecting a malfunction of the mining machine unit (30) based on the determined position change.
Physical Activity and Acculturation Among U.S. Latinas of Childbearing Age

The majority of Latinas of childbearing age is not sufficiently active; a significant health disparity, and is at risk for deleterious health consequences. The study’s objectives were to explore acculturation and associated factors’ effect on engagement in physical activity (PA) among Latinas. Based on data (2008-2011 National Health Interview Survey; N = 7,278), multinomial logistic models predicted odds of adherence to 2008 PA Guidelines for Americans. Among 3,386,680 Latinas, 18 to 47 years, 58.9% (standard error [ SE] = 0.0073) met neither aerobic nor muscle-strengthening recommendations, after controlling for poverty, income, marital status, and competing obligations. Less acculturated Latinas (Spanish-preferring) were less likely to engage in PA than English-preferring counterparts (odds ratio [OR] = 0.57, p &lt; .01). Spanish-preferring foreign-born Latinas have substantially smaller odds of meeting PA guidelines than U.S.-born English-preferring Latinas (OR = 0.3, p &lt; .001). Puerto Ricans and Dominican immigrants are least likely to meet guidelines. Latinas are not homogeneous. Country of origin and acculturation should be considered in future PA interventions.
Towards Regional spEcialisation for Smart growth spirit

Europe faces a moment of global transformation and must now take charge of its future. In the meantime, the world is moving fast and long-term challenges – globalisation, pressure on resources, ageing – intensify. Europe can succeed if it acts collectively, as a Union. Regions need a strategy to come out stronger from the crisis, overcome structural weaknesses and contribute to turn the EU into a smart, sustainable and inclusive economy in accordance with the EU guidelines (e.g. Europe 2020 Strategy) to build a knowledge-based, low carbon economy with high employment levels. This calls for a deep analysis of regional capacities leading to the joint identification of the set of priorities on which stakeholders, regional innovation policies and investments should be focused on in order to better position themselves in the knowledge economy.
TRES is born with the aim to mobilise the innovation capacity and potential of regions towards smart growth. Being a policy intelligence knot for
knowledge exchange and wide cooperation. TRES also intends to boost smart policy processes in order to prepare regions to better face opportunities and challenges and become globally competitive by suggesting new promising recipes. TRES is built on a strong multidisciplinary partnership representing different realities and innovation ecosystems. TRES brings ten project partners and nine regions, a well geographically balanced partnership forming a knot for knowledge generation, strong regional and inter-regional cooperation and transfer.
TRES proposes an innovative Methodology assimilated to a “cooking process” to achieve these objectives and results. In cooking processes tradition is mixed with specialisation, innovation and creativity, being above all spaces for learning, creation and transformation as regions are. TRES suggests three inter-related Components to structure the work: C1 enables sound management and coordination from a strategic, financial and
administrative point of view. C2 enhances and ensures successful involvement of key stakeholders, supports the durability and diffusion of results by means of a web 2.0.-based dissemination and networking strategy, making TRES opinion leader. C3 defines a common framework for Good Practices identification, analysis and exchange that leads to individual Implementation Plans. C3 combines a traditional regional analysis, with a more innovative approach that pursues consortium-based and user-led decision making; it also cooks & tastes new promising recipes and actions for smart innovation and growth by looking at new approaches to increase the impact of innovation across clusters, namely stimulating cluster innovation, opportunity-driven innovation and finding out new methods to pilot these approaches. Recommendations for future action on common policy concerns will be provided making complementary competencies met in new types of collaboration.
Why was the English Malady 'English'?

In 1734, George Cheyne (1671–1743) published ‘The English Malady or, a Treatise of Nervous Diseases of all Kinds; as Spleen, Vapours, Lowness of Spirits, Hypochondriacal, and Hysterical Distempers, Etc.’ (Cheyne, 1734). In the preface, Cheyne wrote: The Title I have chosen for this Treatise, is a Reproach universally thrown on this Island by Foreigners, and all our Neighbours on the Continent, by whom Nervous Distempers, Spleen, Vapours, and Lowness of Spirits, are, in Derision, call’d the ENGLISH MALADY. And I wish there were not so good grounds for this Reflection. The Moisture of our Air, the Variableness of our Weather, (from our Situation amidst the Ocean) the Rankness and Fertility of our Soil, the Richness and Heaviness of our Food, the Wealth and Abundance of the Inhabitants (from their universal Trade), the Inactivity and sedentary Occupations of the better Sort (among whom this Evil mostly rages) and the Humour of living in great, populous, and consequently unhealthy Towns, have brought forth a Class and Set of Distempers, with atrocious and frightful Symptoms, scarce known to our Ancestors, and never rising to such fatal Heights, nor afflicting such Numbers in any other known Nation. These nervous Disorders being computed to make almost one third of the Complaints of the People of Condition in England. One hundred and fifty years later, William Gowers (1845–1915) wrote in his Diseases of the nervous system (Gowers, 1886–88): Hysteria … seems to be a product of the cerebral development that accompanies the process of civilization … Among races that have attained, apparently, an equal degree of civilization, hysteria reaches a higher degree in some than in others, in the French, for example, than in the English.The medical perspective had changed considerably from 1734 to 1888. Cheyne’s broad definition of ‘the English malady’ is not identical with Gowers’ much …
Thyroid hormone–dependent adult pigment cell lineage and pattern in zebrafish

Origin of fish pigment cell for pattern Zebrafish stripes arise from the interactions of pigment cells: black melanophores, iridescent iridophores, and yellow-orange xanthophores. Melanophores and iridophores develop from nerve-associated stem cells, but the origin of xanthophores is unclear. Two studies now reveal that adult xanthophores originate from xanthophores in embryonic and larval fish, when they proliferate to cover the skin before the arrival of black and silver cells in a striped arrangement. Mahalwar et al. show that xanthophores change their final shape and color depending on their location. In black cells, xanthophores appear faint and stellate, but in silver cells, they are bright and compact. Precise superposition creates the blue and golden colors. McMenamin et al. observe the loss of pigment in embryonic xanthophores and the later reappearance in the adult. They show that redifferentiation depends on the thyroid hormone that also limits melanophore population expansion. Science , this issue p. 1362 and p. 1358
Modular Radiance Transfer

Many rendering algorithms willingly sacrifice accuracy, favoring plausible shading with high-performance. Modular Radiance Transfer (MRT) models coarse-scale, distant indirect lighting effects in scene geometry that scales from high-end GPUs to low-end mobile platforms. MRT eliminates scene-dependent precomputation by storing compact transport on simple shapes, akin to bounce cards used in film production. These shapes' modular transport can be instanced, warped and connected on-the-fly to yield approximate light transport in large scenes. We introduce a prior on incident lighting distributions and perform all computations in low-dimensional subspaces. An implicit lighting environment induced from the low-rank approximations is in turn used to model secondary effects, such as volumetric transport variation, higher-order irradiance, and transport through lightfields. MRT is a new approach to precomputed lighting that uses a novel low-dimensional subspace simulation of light transport to uniquely balance the need for high-performance and portable solutions, low memory usage, and fast authoring iteration.
POLICY ENFORCEMENT IN COMPUTING ENVIRONMENT

An embodiment may include policy engine circuitry that may enforce, at least in part, one or more platform resource management policies in a cloud computing environment. The one or more policies may be based, at least in part, upon service arrangements of the cloud computing environment. The one or more policies may establish respective isolated computing environments in the cloud computing environment that may be used by respective users. The enforcement of the one or more policies may result in the respective isolated computing environments being virtually isolated from each other and prevented from interfering with each other in derogation of the one or more policies. The one or more policies may be established, at least in part, via interaction of at least one management process with one or more application program interfaces of the circuitry. Many modifications are possible.
SHAFT FOR A TOOL

A composite shaft 10 for a tool includes an elongate metal section 16 surrounded by a polymeric section with the elongate metal section having engaging means 20 at its opposite ends.
HELICOPTER LANDING GEAR DAMPER

A damper for a landing gear of a helicopter having a barrel, a piston defining a first hydraulic cavity between the piston and a bottom end of the barrel and a second hydraulic cavity between the piston and a top of the barrel, a stack of disc springs disposed within the first hydraulic cavity in a compressed state between the bottom end of the barrel and the piston. Each of the disc springs having a substantially concave side and an opposing substantially convex side, the disc springs stacked in an alternating pattern such that any two adjacent washers have their like sides positioned adjacent to each other. A spring disposed within the second hydraulic cavity such that the spring is compressed between the compression member and the top of the barrel when the piston is in an extended position. A hydraulic fluid is disposed inside at least a portion of the first hydraulic cavity and at least a portion of the second hydraulic cavity. At least one valve is disposed in the piston so as to establish fluid communication between the first hydraulic cavity and the second hydraulic cavity so as to allow bilateral fluid communication between the first hydraulic cavity and the second hydraulic cavity.
Differential Impact of the Neutrophil-Lymphocyte Ratio on the Survival of Patients with Stage IV Gastric Cancer

The neutrophil to lymphocyte ratio (NLR) may be related to progression in several cancers. The aim of this study was to investigate the impact of pretreatment NLR in advanced gastric cancer on the prognosis of the patients stratified by metastatic pattern.We retrospectively investigated clinical data from 191 patients with stage IV gastric cancer who had undergone surgery for primary gastric cancer between 1997 and 2010 at the Department of Surgical Oncology of Osaka City University.All patients had unresectable metastatic factors including peritoneal metastasis (P) and liver metastasis (H). Sixty-one (32%) patients had more than two unresectable factors. We determined a cutoff value of 2.5 for the NLR to be optimal to discriminate the patient's characteristics and divided patients into low (<2.5) and high (>2.5) NLR group for subsequent analysis. In the low NLR group, long survival was found in patients with H, P, or multiple site metastases.Our results suggest that NLR well reflects the progression of critical metastasis and surgical resection might improve prognosis for patients with low NLR. In conclusion, NLR might be used as a predictive marker to decide on surgical therapy for patients with Stage IV gastric cancer.
Thin film epitaxy and magnetic properties of STO/TiN buffered ZnO on Si(001) substrates

Abstract We report integration of epitaxial ZnO films with Si(0 0 1) substrates using STO/TiN buffer layers. It has been demonstrated that the preferential orientation of the a-plane ( 1 1 2 ¯ 0 ) and c-plane (0 0 0 2) of ZnO can be controlled via deposition temperature and oxygen partial pressure. At lower substrate temperatures ZnO grows solely in the (0 0 0 2) orientation, while the ( 1 1 2 ¯ 0 ) orientation was dominant at high substrate temperatures and low oxygen pressures. At higher pressures, the (0 0 0 2) orientation is preferred, while ( 1 1 2 ¯ 0 ) becomes weaker and a ( 1 0 1 ¯ 2 ) ZnO appears. Epitaxial relationships have been determined from X-ray diffraction φ-scans and it was found that both c- and a-ZnO had two types of orientations due to the cubic symmetry of the STO buffer layer. The orientation relationship of c-ZnO on STO(0 0 1) was ZnO(0 0 0 1) ∥ STO(1 0 0); ZnO[ 1 1 2 ¯ 0 ] ∥ STO[1 1 0] and ZnO[ 1 ¯ 2 1 ¯ 0 ] ∥ STO[ 1 ¯ 1 0 ], while that of a-ZnO on STO(0 0 1) was ZnO( 1 1 2 ¯ 0 ) ∥ STO(1 0 0); ZnO[ 1 1 2 ¯ 0 ] ∥ STO[1 1 0] and ZnO[0 0 0 2] ∥ STO[ 1 ¯ 1 0 ]. High-resolution transmission electron microscopy studies revealed atomically sharp interfaces with no reaction at the interface. Reversible d0 ferromagnetism was found to be present in both ZnO and STO layers. Our electron-energy-loss spectroscopy studies conclusively rule out the presence of any external ferromagnetic ions or impurities. Taken together, our data indicate that the ferromagnetic order in these undoped oxides might be defect mediated.
COATED GLASS SLIDE FOR ENHANCED THIN TISSUE SECTION ADHESION

It is provided a substrate such as a microscopic slide coated with a layer of metal, such as chrome, titanium or aluminum, particularly a layer of less than 5 nm, or between 3 nm and 1 nm for adhering a sample, such as a tissue sample.
HIGHLY POROUS SELF-COHERED WEB MATERIALS

The present invention is directed to implantable bioabsorbable non-woven self-cohered web materials having a high degree of porosity. The web materials are very supple and soft, while exhibiting proportionally increased mechanical strength in one or more directions. The web materials often possess a high degree of loft. The web materials can be formed into a variety of shapes and forms suitable for use as implantable medical devices or components thereof.
Improvement of production capacity in ESTREL EAD

This project proposal aims at acquiring technologically innovative software, allowing complex analysis and extraction of diverse information from pre- or currently recorded video streams. For the implementation of the project, an entirely new high-tech hardware infrastructure will be purchased and built to serve the software and thus help optimise production processes and ensure continuity for the provision of sustainable services. The main objectives of the project are to increase the production capacity of the company and increase its export potential by diversifying the range of services offered by ESTREL EAD with services aimed at identifying and extracting specific information from a variety of video sources under constant video monitoring. The implementation of the project will allow Estrel EAD to offer IT services related to automatic monitoring of television content. At present, this service is offered on the Bulgarian market in rudimentary form, through analysis of TV content through human factor. In the presence of a competitive IT platform, this service can be offered in an automated and many times more precise option. Clients of this type of service would be all major advertisers in and outside Bulgaria, as it would allow them to make a precise analysis of the distribution and effectiveness of their media budgets. A number of market studies show a sharp increase in the efficiency of the use of marketing budgets after offering a quality automated IT service related to analysis of video content, which creates prerequisites for guaranteed successful implementation of the service in Bulgaria as well.
Targeted Therapy for Chronic Lymphocytic Leukemia: Current Status and Future Directions

The majority of patients with chronic lymphocytic leukemia (CLL) respond to chemo-immunotherapy. However, long-term remission remains elusive and the majority of patients will die of complications related to CLL. In this review we discuss the recent developments in targeted therapy for CLL. Targeted therapy has evolved beyond the cell surface targeting of CD20 with rituximab. Our review focuses on the evolution of antibody therapy in CLL, strategies to target effector T cells to the tumor, inhibition of the B-cell receptor signaling pathway, and finally targeting the mediators of apoptosis. With our improved understanding of the biology of CLL, the evolution of targeted therapy has resulted in significant clinical responses in patients who are refractory to traditional treatment options and holds the potential for a future where we can manage this disease without chemotherapy.
AUDIO DIRECT FROM POWER SUPPLY

A novel circuit that generates direct audio from a power supply that uses no power amplifier and that can provide full isolation to any impedance load. It has no power amplifier output stage and has a zero signal-to-noise ratio when there is no signal input because the circuit is designed with MOSFETS that do not conduct unless there is a signal input.