SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Role of s-nitrosylation of epigenetic modifiers in vascular regeneration

This MSCA-IF describes a career development plan to prepare Dr. Matrone to become an independent investigator. This program builds on Dr. Matrone’s background as a talented biologist in cardiovascular regeneration and will provide him with the skills to decipher the mechanisms of S-Nitrosylation of epigenetic modifiers during tissue regeneration in zebrafish (Danio rerio). These studies will lay the foundations for future studies that will be carried out by Dr. Matrone as an independent investigator. The project will be carried out at the Centre for Cardiovascular Sciences at the University of Edinburgh. Dr. Matrone’s mentor is Dr. Martin Denvir, Reader in Cardiology. Dr. Denvir is an excellent mentor with extensive experience in cardiovascular disease. The MSCA-IF will consist of structured mentorship, formal coursework, a provocative research project and a program of career transition.
Dr. Matrone’s research proposal is based on supportive preliminary data. Changes in S-nitrosylation of epigenetic modifiers in response to injury will be assessed in nuclear proteins extracts from injured tissues and identified by mass spec-proteomic analyses. The most interesting and novel epigenetic modifiers will be further studied in vascular development and regeneration following laser injury in the dorsal aorta. Candidate proteins will be knocked out by CRISPR/Cas9 or knocked down by morpholinos and will be mutated by site-specific mutagenesis. Furthermore, Dr. Matrone will assess the role of the innate immune system and iNOS in S-nitrosylation of nuclear proteins (e.g. epigenetic modifiers). He will confirm and refine his preliminary data showing that the innate immune system and iNOS trigger tissue regeneration. He will pharmacologically and genetically modulate TLR3, NFkB and iNOS and will take advantage of transgenic lines to track changes in the immune system activation in situ. These studies may provide insights toward novel strategies for tissue regeneration in humans.
L’alternance dans l’Association Internationale des Mouvements familiaux de formation rurale : les quatre piliers des Centres éducatifs familiaux de formation par alternance

Le système pédagogique de l'alternance, présente une actualité croissante dans de nombreux pays et à différents niveaux d'enseignement, y compris au niveau universitaire. La plupart des établissements d'enseignement par alternance (Centres Éducatifs Familiaux de Formation par Alternance, CEFFA) qui dispensent un enseignement général et professionnel formel aux niveaux pré-universitaires, font partie d'un réseau –présent dans plus de 30 pays– appelé Association Internationale des Mouvements Familiaux de Formation Rurale (AIMFR). Cette organisation, née en Afrique sous l'impulsion de l'Europe, a actuellement sa plus grande expansion en Amérique. Elle a évolué pour consolider son identité en fonction des besoins de la formation et pour mettre en valeur les principes qui ont inspiré sa création. Le présent article propose une réflexion sur les éléments clés des CEFFA appartenant à l'AIMFR (ses « quatre piliers »). Pour ce faire, il part d'une recension bibliographique et des expériences de la pédagogie CEFFA, plus que de faits concrets analysés selon une méthodologie particulière. Il présente les aspects historiques de manière assez détaillée, du premier centre éducatif aux centres d'aujourd'hui, en passant par la naissance et l'évolution de l'AIMFR. Il présente également des éléments conceptuels visant à expliquer brièvement l'importance des « quatre piliers » des CEFFA. Et il établit leur lien avec le territoire à travers les associations locales des centres éducatifs, qui se définissent comme créatrices de capital social « en action ». Ce dernier aspect est une contribution singulière de l'article. Néanmoins, la réflexion historique et conceptuelle, qui structure l'approche théorique du texte et souligne l'importance des piliers et de l'AIMFR, reste essentielle. Pour finir, l'article mentionne quelques clés pour que les CEFFA adhérant à l'AIMFR puissent continuer à être un système intégré et intégrateur, ancré dans la réalité, enraciné dans l'expérience et fondé sur la valeur des personnes.
OXYGEN SUPPLY UNIT HAVING AN OXYGEN GENERATOR

The invention relates to an oxygen supply unit equipped with an oxygen generator for supplying one or more oxygen masks. These masks and the generator are accommodated in an openable housing. The oxygen supply unit is improved in that a highest possible savings in weight is achieved while maintaining the stability of the entire arrangement so that oxygen generators can be installed which are useable for a longer duration. For this purpose, the oxygen generator is attached to a strut which is releasably connected to a reinforcing frame of the housing.
MicroRNA in radiotherapy: miRage or miRador?

At least half of all cancer patients will receive radiation therapy. Tumour radioresistance, or the failure to control certain tumours with this treatment, can result in locoregional recurrence; thus there is great interest in understanding the underlying biology and developing strategies to overcome this problem. The expanding investigation of microRNA in cancer suggests that these regulatory factors can influence the DNA damage response, the microenvironment and survival pathways, among other processes, and thereby may affect tumour radioresistance. As microRNA are readily detectable in tumours and biofluids, they hold promise as predictive biomarkers for therapy response and prognosis. This review highlights the current insights on the major ways that microRNA may contribute to tumour radiation response and whether their levels reflect treatment success. We conclude by applying the potential framework of future roles of miR in personalised radiotherapy using prostate cancer clinical management as an example.
Influence of pre-processing and distance on spectral classification: A simulation study

An investigation on the influence of pre-processing on the recognition of chemically similar areas in a spectral image, using simulated data. Fictitious spectra of mixtures of five components at varying concentrations were corrupted by different types of noise to mimic typical signals from Raman imaging. They were then processed by various combinations of pre-processing functions, including baseline correction, smoothing, normalization and Principal Components (PC) compression, and by two clustering algorithms ( k -means and agglomerative hierarchical clustering) to recognize the original mixtures. The clusters obtained by the different pre-processing combinations and distance metrics were evaluated by statistical parameters (Rand index and silhouette coefficient) and visual inspection. Perhaps the best performing on the basis of all considered criteria is the combination using an adaptive polynomial detrending, a slight smoothing, normalization by the total signal intensity and compression by 4 PCs (spanning 80% of the total variance). More detailed analysis was also carried out on subsets of the whole data with a particular type of noise and on the influence of each single pre-processing/clustering variable.
Social influences on smoking in middle-aged and older women.

The purpose of this study was to examine the role of 2 types of social influence--general social support and living with a smoker--on smoking behavior among middle-aged and older women in the Women's Health Initiative (WHI) Observational Study. Participants were postmenopausal women who reported smoking at some time in their lives (N=37,027), who were an average age of 63.3 years at baseline. Analyses used multiple logistic regression and controlled for age, educational level, and ethnicity. In cross-sectional analyses, social support was associated with a lower likelihood and living with a smoker was associated with a higher likelihood of being a current smoker and, among smokers, of being a heavier smoker. Moreover, in prospective analyses among baseline smokers, social support predicted a higher likelihood and living with a smoker predicted a lower likelihood of smoking cessation 1-year later. Further, in prospective analyses among former smokers who were not smoking at baseline, social support predicted a lower likelihood and living with a smoker predicted a higher likelihood of smoking relapse 1-year later. Overall, the present results indicate that social influences are important correlates of smoking status, smoking level, smoking cessation, and smoking relapse among middle-aged and older women.
Le peuplement paléolithique de l’Afrique du Nord-Est dans son contexte macrorégional

Cet article est une synthèse des connaissances actuelles sur le Paléolithique d’Afrique du Nord-Est (actuels Egypte et Soudan) vues sous l’angle de l’histoire des recherches dans cette région. En particulier, cette région clé par sa position géographique dans les problématiques de dispersions humaines hors d’Afrique (et retour en Afrique) se situe également à la croisée de deux « écoles » d’étude de la préhistoire, ce qui est reflété dans l’emploi parallèle de deux nomenclatures différentes (européenne « Paléolithique » et africaine « Stone Age ») pour la description de son registre préhistorique. Ici, le terme Paléolithique est employé comme un terme générique faisant référence à la préhistoire pléistocène. Les grandes étapes de la construction du cadre chrono-culturel du Paléolithique d’Afrique du Nord-Est sont retracées, afin de comprendre les éventuels biais associés aux données sur le Paléolithique de la région. Pour chaque phase du Paléolithique, les données actuellement disponibles sont synthétisées afin de discuter de la place de l’Afrique du Nord-Est dans son contexte macro-régional. This article reviews currently available data on the Palaeolithic of North-Eastern Africa (current Egypt and Sudan), from the perspective of the history of the research in this region. In particular, this region is key in questions related to hominin dispersals out of (and back into) Africa, but is also at the crossroads of two different “schools” for the study of prehistory, which is visible in the parallel use of two different nomenclatures (the European “Palaeolithic”, and the African “Stone Age”) for the description of its prehistoric record. Here, the term Palaeolithic is used as a generic term referring to Pleistocene prehistory. The main steps of the construction of the chrono-cultural framework of the North-Eastern African Palaeolithic are summarised, in order to understand the potential biases associated with the Palaeolithic data of the region. For each phase of the Palaeolithic, currently available data are reviewed in order to discuss the place of North-Eastern Africa in its macroregional context.
WALKER HAVING AUTOMATICALLY ACTIVATED PROTECTIVE DYNAMIC PADDING

A walking aid (100, 200) has been configured with static padding (112) and air bags (114) to protect the user in case of a fall. The air bags (114) are generally not deployed. However, the walking aid has a tilt sensor (128) which, when a fall is detected, triggers air bag ignitors (116). In one embodiment, the tilt sensor (128) may comprise one or an array of sensors, and may further be coupled through microprocessor control to a dynamic active suspension ( 102) that controls both the height of the walker and the height of individual legs such that the walker will land softly, while adjusting individual leg heights where necessary or appropriate to stabilize the user to reduce the chance of a fall. In addition to providing more extensive protection for the user, the walking aid has several additional options which increase the comfort and convenience it offers. Such options can include locking hinges (120), allowing the walking aid to fold up; rubber (124) on the end of the legs where they contact the ground; wheels (126) on the legs; brakes for the wheels; height adjustable legs (102, 122); a water bottle holder; a basket; a removable or folding seat; a dashboard (140) including various communications devices such as cellular telephones, emergency call buttons, locators, and the like; and audio-video devices.
PROACTIVE SAFETY METHODS, DEVICES AND SYSTEMS, AND SAFETY METHODS AND DEVICES FOR BLOCKING OPERATION OF LATCHES FOR OCCUPANT INGRESS AND EGRESS CLOSURE PANELS

A method for controlling a blocking component for a latch of a closure panel of a vehicle, the latch having latch components including a ratchet and pawl, the method comprising: determining whether an occupant is in the vehicle and whether a speed of the vehicle is above a first threshold; and blocking release of the latch by positioning the blocking component whenever the occupant is in the vehicle and the speed is above the first threshold, automatically without occupant intervention, into a blocking position adjacent to at least one of the latch components to restrict movement of the at least one of the latch components which movement would cause the latch to open, wherein the blocking position is adjacent either the ratchet or the pawl, and restricts movement of the ratchet or pawl, respectively.
Lamellar eutectic growth with anisotropic interphase boundaries

We present a numerical study of the effect of a free-energy anisotropy of the solid- solid interphase boundaries on the formation of tilted lamellar microstructures during directional solidification of nonfaceted binary eutectic alloys. We used two different methods - phase-field (PF) and dynamic boundary-integral (BI) - to simulate the growth of periodic eutectic patterns in two dimensions. For a given Wulff plot of the interphase boundary, which characterizes a eutectic grain with a given relative orientation of the two solid phases, the lamellar tilt angle depends on the angle between the thermal axis z and a reference crystallographic axis. Both PF and BI results confirm the general validity of a recent approximate theory which assumes that, at the trijunctions, the surface tension vector of the interphase boundary is parallel to z. In particular, a crystallographic locking of the lamellae onto a direction close to a deep minimum in the Wulff plot is well reproduced in the simulations.
Nemo : hyper-network for electromobility

Electromobility is a major factor towards transport decarbonisation. However a number of challenges (limited charging options, lack of interoperability, absence of a unified identification/payment process, energy grid overload, expensive charging tariffs) limit the potential for interoperable and seamless electromobility services to a wider of actors and geographic area, hindering electromobility adoption. These challenges stem from lack of standardisation in electromobility data and services. NeMo addresses all issues through a pan-European eRoaming Hyper-Network that allows seamless and interoperable use of electromobility services throughout Europe. In addition it provides an Open Cloud Marketplace, where third parties can provide services (B2B2C) aiming to increase EV attractiveness. The NeMo Hyper-Network is a distributed environment with open architecture based on standardised interfaces, in which all electromobility actors, physical (i.e. CPs, grids, EVs) or digital (i.e. CPOs, DSOs, etc.), can connect and interact seamlessly, exchange data and provide more elaborate electromobility ICT services in a fully integrated and interoperable way both B2B and B2C. The connection will be based on dynamic translation of data and services interfaces according to needs of the specific scenarios and involved stakeholders. NeMo is not just another proprietary platform for electromobility but a full open eco-system allowing continuous and uninterrupted provision of data and services. NeMo will raise awareness, liaise with standardisation bodies and contribute to the evolution of protocols and standards by developing public Common Information Models which incorporate all existing electromobility related standards and constantly update them to reflect standards evolution. NeMo will also propose sustainable business models for all electromobility actors opening new opportunities for SMEs and EU Industry.
Unsavoury Employer Practices: Understanding Temporary Migrant Work in the Australian Food Services Sector

Why do employers in specific sectors use migrant workers to a significant extent? Taking temporary migrant work in the Australian food services sector as a case study, this article argues that employer demand for migrant workers is shaped by two forms of social regulation: the immigration controls that create a supply of different kinds of migrant workers, and the labour market norms and institutions that operate within a specific industrial sector. Specifically, the article argues that the cost-minimization strategy of the Australian food services sector in conjunction with its precarious work norms result in ‘demand’ on the part of employers in the sector for vulnerable workers to perform precarious jobs. Such ‘demand’ is met in part by the workers supplied through temporary labour migration programs who may be an attractive form of precarious labour because of the conditionalities they experience. The normalization of noncompliance with labour laws by food services employers, that stems from the broader culture of illegality in the sector, further heightens the vulnerability (and attractiveness) of temporary migrant labour, allowing employers to ‘demand’ illegal working conditions.
Competencias narrativas de alumnos sordos y oyentes en contextos bilingües de España e Italia

El objetivo principal del estudio es analizar las competencias narrativas de alumnos sordos y oyentes escolarizados en contextos bilingües de España e Italia. Para ello, se ha adoptado un enfoque metodológico descriptivo donde la muestra se obtuvo de manera incidental en base a los criterios: modelo bilingüe y enfoque de enseñanza. En la obtención de datos se pidió al alumnado que escribiera un texto tras la visualización de la secuencia “Frog, ¿where are you?”. Posteriormente, se procedió al análisis de los textos escritos a partir de un modelo elaborado integrando las aportaciones de varios autores. Los resultados indican que los alumnos sordos y oyentes procedentes del contexto italiano, en comparación con los alumnos españoles, escriben textos con una mayor longitud y complejidad sintáctica y utilizan con mayor frecuencia los dispositivos de valoración. Además, no existen diferencias significativas entre alumnos sordos y oyentes de Italia, en el uso de las proposiciones subordinadas y de los dispositivos de valoración relacionados con los estados internos-mentales. Así, el desarrollo de las competencias narrativas en alumnos oyentes y sordos puede ser atribuida a las propuestas didácticas implementadas en el contexto escolar italiano y caracterizadas por el enfoque pragmático de la escritura centrado en la textualidad.
TRADITIONAL KNOWLEDGE TO WILD PLANTS USED IN FOOD AND FOOD ADDITIVES BY IRULA TRIBES IN SIRUVANI HILLS, COIMBATORE DISTRICT OF TAMIL NADU, INDIA

ABSTRACT:The present study was carried out during 2012 - 2013 in the study area Siruvani hills rich in biodiversity and ethnic community. The Irula tribes are the main dwellers of these forests. The Irula tribal hamlets are located in the region of Siruvani hills such as Seengapathi, Sarkarborathi and Jagirborathi. During this study the plant species used by irula tribes for all kinds of food and food additives were documented. The different types of wild plants and plant parts are mostly used in food preparations for day-to-day life. They traditionally used 94 edible plants belonging to 77 genera and 48 families. The botanical name, family, vernacular name, habit and mode of preparation were given.
Managing parallelism for stream processing in the cloud

Stream processing applications run continuously and have varying load. Cloud infrastructures present an attractive option to meet these fluctuating computational demands. Coordinating such resources to meet end-to-end latency objectives efficiently is important in preventing the frivolous use of cloud resources. We present a framework that parallelizes and schedules workflows of stream operators, in real-time, to meet latency objectives. It supports data- and task-parallel processing of all workflow operators, by all computing nodes, while maintaining the ordering properties of sorted data streams. We show that a latency-oriented operator scheduling policy coupled with the diversification of computing node responsibilities encourages parallelism models that achieve end-to-end latency-minimization goals. We demonstrate the effectiveness of our framework with preliminary experimental results using a variety of real-world applications on heterogeneous clusters.
Open access pilot plants for sustainable industrial scale nanocomposites manufacturing based on buckypapers, doped veils and prepregs

Two FP7 European projects ELECTRICAL and SARISTU aim to develop methods to manufacture CNT reinforced multifunctional composites compatible with current industrial manufacturing processes. According to the results, three CNT integration strategies appear as promising methods to be driven towards an industrial scale manufacturing process: buckypapers, CNTtreated prepreg and CNT doped nonwoven veils. Although each of the technologies can act separately they can be combined synergistically in a way that a higher multifunctional level can be achieved according to the final requirements of the application. 
This project aims to develop open access pilot lines for the industrial production of buckypapers, CNT treated prepreg and CNT doped non-woven veils for composite applications in sectors such as Aeronautic and Automotive. The purpose is to efficiently and economically manufacture components using novel developed at a scale suitable for industrial uptake. The developed facilities will not only provide increased capabilities to the operating company but also offer a network of nanorelated manufacturing facilities suited to the needs of related SMEs. A European platform of nanobased pilot lines will be created to which companies, and more precisely SMEs, can gain access and make use of the facilities as well as the experience and knowledge of the operating RTO.The partners will work with existing EU clusters and initiatives aimed at the establishment of an EU nanosafety and regulatory strategy framework to ensure the safe use of these products particularly at an industrial scale. This will be achieved through collaboration with end users to ensure the developed products are accepted within existing health and safety procedures or through the introduction of new ones.PLATFORM proposes solutions that will generate new market opportunities for European Aeronautic and Automotive components manufacturing offering to OEMs new added-value products based on nano-enabled products