SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Direct visualization of hepatitis C virus-infected Huh7.5 cells with a high titre of infectious chimeric JFH1-EGFP reporter virus in three-dimensional Matrigel cell cultures

Identification of the hepatitis C virus (HCV) JFH1 isolate enabled the development of infectious HCV cell culture systems. However, the relatively low virus titres and instability of some chimeric JFH1 reporter viruses restricts some uses of this system. We describe a higher-titre JFH1-EGFP reporter virus where the NS5A V3 region was replaced with the EGFP gene and adapted by serial passage in Huh7.5 cells. Six adaptive mutants were identified: one each in E2, P7 and NS4B, plus three in the NS5A region. These adaptive mutants increased the reporter virus titres to 1×10 6 immunofluorescent focus-forming units ml −1 , which is the highest titre of JFH1-EGFP reporter virus reported to our knowledge. This chimeric virus did not lose EGFP expression following 40 days of passage and it can be used to test the activity of HCV antivirals by measuring EGFP fluorescence in 96-well plates. Moreover, this reporter virus allows living infected Huh7.5 cells in Matrigel three-dimensional (3D) cultures to be visualized and produces infectious viral particles in these 3D cultures. The chimeric NS5A-EGFP infectious JFH1 reporter virus described should enable new studies of the HCV life cycle in 3D cell cultures and will be useful in identifying antivirals that interfere with HCV release or entry.
Liquid container and liquid supplying system

A liquid container detachably mountable to a recording apparatus to which a plurality of liquid containers are detachably mountable, wherein the recording apparatus includes apparatus electrical contacts corresponding to the liquid containers, respectively, photoreceptor means for receiving light, and an electric circuit connected with a line which is commonly connected with the apparatus electrical contacts, the liquid container includes a container electrical contact electrically connectable with one of the apparatus contacts; an information storing portion capable of storing at least individual information of the liquid container; a light emitting portion; a controller for controling emission of light of the light emitting portion in response to a correspondence between a signal indicative of individual information supplied through the container electrical contact and the information stored in the information storing means.
FLOCKED SLURRIED THERMOSETTING ADHESIVE ARTICLE

A design and process are provided in which a thermosetting adhesive layer is applied as a slurry to a flocked surface.
DEVELOPPER EXPERIMENTER ET PERENNISER DES DISPOSITIFS INNOVANTS D'APPUI AUX TERRITOIRES

The ADEP RFO stems from some of the facts that today define the situation of many eligible areas under Objective 1 and 2.These are under-populated rural territories or declining industrial zones which are continuing to decline demographically and economically in spite of a series of policies for action. One of the reasons for this failure has been the unsuitability of classic procedures for action, which have been too sector-based and inflexible. There is therefore an urgent need to create territorial policies that are better suited to the needs of zones in difficulty, providing them with tools and effective contractual procedures. Overall objective / Objectif général ADEP has chosen to work to achieve greater efficiency in regional development policies for Objective 1 and 2 zones. The partner regions have therefore requested that their efforts focus on human resources and, especially, on individualized support methods for project leaders (training and capacity building). On the basis of shared know-how and testing, ADEP will allow each region to improve its own policies and to stress human resources as a means of achieving development. Expected results / Résultats attendus On an interregional level, the purpose of the ADEP RFO is to propose an individualised European model for support for local project leaders (training / capacity-building) from 2006. While respecting certain basic principles such as integrated development, public-private contracts, a mainstreamed, multisector approach and bottom-up methods, the model could serve as a starting-point for the creation of a European resources centre for links between development and human resources. On a regional level, the ADEP RFO should be able to support local pilot initiatives for development.The lessons learnt from such pilot projects will be brought together in the framework of the regional resource centres which will disseminate good practices and development methods among other agents and/or local or regional institutions.
Slow and fast light propagation in a triple quantum well nanostructure

In this paper, we investigate the absorption and dispersion properties of a weak probe field in a triple quantum well nanostructure by using the incoherent pumping fields. A deep 7.1 nm-thick GaAs well is coupled, on one side, to two shallow 6.8 nm-thick Al0.2Ga0.8As wells by a 2.5 nm-thick Al0.4Ga0.6As barrier. The two shallow wells are separated by a 2.0 nm-thick Al0.4Ga0.8As barrier. Both sides of quantum well contact with 36 nm Al0.4Ga0.6As. Therefore, this type of triple quantum well nanostructure can be used as a suitable medium for studying the effect of spontaneously generated coherence (SGC) and interference between incoherent pumping fields on absorption and dispersion properties of weak probe light. We find that the interferences from spontaneous emission and incoherent pumping processes can change the slope of dispersion and group velocity of the probe light from slow to fast or vice versa. Moreover, it is demonstrated that the group velocity of the light pulse can be controlled with the rates of incoherent pumping fields.
Mediterranean Interregional Electromobility Networks for intermodal and interurban low carbon transport systems

EnerNETMob aims to draft, test and improve parallel “Sustainable Electromobility Plans” according to common standards and low carbon policies, in order to set an “Interregional Electromobility Network” crossing cities of all transnational MED area._x000D_
Project promotes sharing mobility and land-sea intermodality using electric transport systems, by implementing interurban and interregional pilot networks of Electric Vehicles Supply Equipment (EVSE) also co-powered by Renewable Energy Sources. _x000D_
By integrating the SUMP and SEAPs models, the “Sustainable Electromobility Plans” will be developed to reach 2 main challenges:_x000D_
- to implement and extend “Interregional Electromobility Networks” inside and beyond MED area, following common approaches and design guidelines for electric transport infrastructures/services;_x000D_
- to implement pilot small-scale investments on electromobility for interurban and intermodal connections in order to allow longer trips and test network at transnational level. _x000D_
2014/94/EU Directive provided preliminary guidelines to develop charging infrastructures in EU territory. However, Member States have still not implemented integrated EVSE networks at European level with same communication protocols and planning models._x000D_
Therefore, on the basis of existing Best Available Technologies, project will develop electromobilty solutions and will test pilot actions to overcome medium-trip limitations and to coordinate future investments on electric transport in MED area.
Variable Outcome in Quintuplets Pregnancy Based on Obstetric Care

The incidence of multiple pregnancies has increased dramatically over the last few years in developed countries, largely attributed to delayed childbearing and the increasing use of assisted reproduction technologies and ovulation inducing hormones. Relatively few countries have population-based statistics covering birth statistics. Of those that do, the numbers of quintuplet pregnancies rose sharply in the nineties while, at the same time, their delivery rates decreased greatly because of the use of fetal reduction. Fetal reduction is not possible or legal in some countries, Poland being one of them, and therefore obstetricians are faced with the challenges of quintuplet deliveries. Conservative treatment and management is difficult, and outcomes often vary greatly. Despite this, expert care provided at tertiary care centers can positively influence outcomes. The objective of this article is to present different care options and their consequences in two illustrative cases, as well as to establish a set of obstetric care and management goals that would allow prolongation of the gestation time. Quintuplet pregnancy is rare but poses relevant clinical problems to both the obstetrician and the neonatologist. It should be managed with close cooperation between all concerned. Due to the extreme and invariable risk of premature delivery associated with quintuplet pregnancies, we recommend early diagnosis, adequate prenatal care at one tertiary medical center, routine hospitalization and bed rest, repeated ante partum ultrasound surveillance with tests of fetal well-being, tocolytic therapy at first signs of the risk of premature labor, and specialized neonatology care after delivery.
SPR Biosensing MUA/Poly-L-lysine Platform for the Detection of 2,4-Dinitrophenol as Small Molecule Model System

Surface Plasmon Resonance assays are being developed as alternative biodetection methods for a great number of pesticides and toxins. These substances typically have low molecular weight, making it necessary to perform competitive inhibition immunoassays. In most of the cases, the strategy is to immobilize a protein derivative of the analyte, which usually involves the appearance of nonspecific protein binding which limits the detection range of the assay. In this work we present results of a poly-L-lysine (Au-MUA-PLL) based sensor platform for quantitative determination of 2,4-dinitrophenol as model system for small molecular weight substances detection. The prepared sensor chip was characterized by means of Atomic Force Microscopy, Surface Plasmon Resonance, and Surface Enhanced Raman Spectroscopy. Experiments verified the absence of nonspecific protein adsorption to Au-MUA-PLL surfaces and the improvement of the competitive inhibition assays performance in comparison with single and mixed thiol self-assembled monolayers. The possibility of directly immobilizing 2,4-dinitrophenol to the poly-L-lysine containing platforms leads to an improvement in the detection of the soluble analyte by the competitive inhibition assay avoiding undesirable nonspecific protein adsorption. Therefore, Au-MUA-PLL surfaces constitute a suitable alternative for quantitative detection of small molecules when nonspecific adsorption cannot be avoided.
The role of neuroinflammation in alzheimer’s disease

Alzheimer’s disease (AD) is a major public health problem with substantial economical and social impacts worldwide. Despite intense research, the pathological mechanisms of AD are still unclear. Under homeostasis, a delicate balance is struck between disposal of pathogenic proteins by the brain’s immune cells, microglia, and the inflammation produced by these cells. Indeed, during an acute activation, microglia are protective, but if microglia enter an over-activated state they can induce chronic inflammation through oxidative stress that in turn leads to neuronal damage. Thus, gaining data on the chain of events involved in microglial action is a prerequisite to understanding AD. This project is a large interdisciplinary collaborative effort involving well-established methods such as confocal imaging and transgenic zebrafish, with newly developed photopharmacological tools. Drs Kettunen, Grøtli and Andréasson provide the world-leading expertise required for the project. By coordinating this project, Dr Mourabit will gain invaluable experience in biomedical research, photochemistry, project management, supervision, and the production of scientific results. The novel photoresponsive probes used here will allow for photonic in vivo de/activation of microglia, generating new information on their spatiotemporal activity, in real-time. This state-of-the-art resolution of cell-tracking and control of microglial signalling will provide innovative data on the pathology of neuroinflammation. We believe this interdisciplinary team will push the boundaries of research in AD. This project has the potential to identify new treatments for AD, and influence the direction of neurobiology. This project will create a unique career opportunity for Dr Mourabit, enabling him to crossover from an environmental background to biomedical research. The marrying of such interconnected disciplines will help Dr Mourabit set the foundations of an eclectic and vibrant research group.
Potential Realization System With Electronic Communication Processing for Conditional Resource Incrementation

Selected embodiments of the present disclosure provide methods, systems and media for systematically processing electronic communications for conditionally incrementing resources. In certain embodiments, electronic communications are received and processed in order to evaluate potential realization assistance functions by potential realization assistants according to processes that include resource incrementations that are conditioned on satisfactory potential realization function processing. Other methods, systems and media are also provided.
Integrated Nanophotonic Devices

Nanophotonics is a newly developing and exciting field, with two main areas of interest: imaging/computer vision and data transport. The technologies developed in the field of nanophotonics have far reaching implications with a wide range of potential applications from faster computing power to medical applications, and smart eyeglasses to national security. Integrated Nanophotonic Devices explores one of the key technologies emerging within nanophotonics: that of nano-integrated photonic modulation devices and sensors. The authors introduce the scientific principles of these devices and provide a practical, applications-based approach to recent developments in the design, fabrication and experimentation of integrated photonic modulation circuits. For this second edition, all chapters have been expanded and updated to reflect this rapidly advancing field, and an entirely new chapter has been added to cover liquid crystals integrated with nanostructures. * Unlocks the technologies that will turn the rapidly growing research area of nanophotonics into a major area of commercial development, with applications in telecommunications, computing, security, and sensing * Nano-integrated photonic modulation devices and sensors are the components that will see nanophotonics moving out of the lab into a new generation of products and services* By covering the scientific fundamentals alongside technological applications, the authors open up this important multidisciplinary subject to readers from a range of scientific backgrounds
Development of an improved extraction and HPLC method for the measurement of ascorbic acid in cows' milk from processing plants and retail outlets

Summary

An improved extraction (2.5% HPO3, 5 mm dithiothreitol) and HPLC quantification methodology using a C–18 column at 35 °C and 0.1 m acetic acid (98%) and acetonitrile (2%) mobile phase was developed to quantify total ascorbic acid (AA) in commercial whole/semi-skim/skim raw/pasteurised/UHT milk packaged in opaque bags, transparent plastic, cardboard and Tetra Brik™. AA content ranged from 0.21 to 10 and from 3.4 to 16 mg L−1 in milk from retail outlets and processing plants, respectively, and was higher in organic milk. For same processor/lot samples, pasteurised milk showed higher AA content than UHT milk. This was not true for retail outlets samples. AA content was similar for whole/semi-skim and semi-skim/skim milk, but not for whole/skim comparisons. Among UHT samples, the AA content trend was whole<semi-skim<skim and lower for UHT milk in opaque plastic and Tetra Brik™ container. After 14 days at 4 °C in the dark, AA losses ranged 35–83% depending on milk type and preservation method with a higher AA retention in unopened containers.
Reconstruction of climate and hidden biodiversity in lakes: development of innovative paleoaproaches

Increase of temperature and biodiversity loss are major threats in the early warning systems of the planet, the high-altitude ecosystems. The analysis of sediment records provides evidence on past response of species to climatic changes, offering a unique framework to anticipate/expand our ability to manage these ecosystems. Among the commonly used paleoindicators, the analysis of cladoceran subfossils has relied on classical morphological counting. However, recent advances in mass-spectrometry, which now need much lower sample sizes, and in molecular biology, with the use of sedimentary DNA, offer unprecedented opportunities to develop innovative approaches based on these REMAINS. The main goal of this project is to provide new advances to i) use cladoceran chitin as a paleothermometer and ii) establish a standard methodology to use their DNA in sediments. The intellectual merits of this proposal are threefold. First, it will use cutting-edge technology to measure subfossil chitin in lab assays, in situ calibration and validation phases. Second, it will address a new biological group not previously studied in ancient DNA. Last, by establishing new analytical methods for a very common component of lake sediments, the project will open up a new field in Paleolimnology and highlight how much hitherto untapped information is stored in paleorecords. The research approach will involve (i) the quantification of contribution of water-diet to H and O isotopes in chitin (ii) the field calibration between isotopic composition of chitin and temperature (iii) the paleothermometer validation in the sediment (iv) the establishment of a library of cladocerans by a genome skimming and (v) the development of a specific assay to identify them in sedimentary DNA. Framed in the “Environment & Climate Action” area from HORIZON 2020, the project addresses gaps in the knowledge needed to understand past changes and to protect natural resources, illustrated here by Sierra Nevada Mountains
The new era of european cmb cosmology with the south pole telescope

The goal of NEUCosmoS is to unravel some of the most severe inconsistencies that are currently threatening the so-far very successful standard model of cosmology (ΛCDM). The most critical one is the steadily growing 5σ difference in the measurement of the expansion rate of the universe today, the Hubble constant, from early-time probes (CMB) versus late-time ones (supernovae Ia). Additional discrepancies persist in the amplitude of matter perturbations, σ8, and in other fundamental parameters, such as the curvature of the universe. These anomalies, if confirmed, will have revolutionary implications for physics.
In this context, NEUCosmoS will provide new, ground-breaking insight through the development of a robust analysis pipeline, allowing us to extract the most precise cosmological information from one of the forefront, post-Planck CMB experiments: the South Pole Telescope 3rd-Generation (SPT-3G). SPT-3G will measure the CMB small-scale polarization with unprecedented accuracy over the next 5 years, opening an entirely new window in CMB cosmology, with potentially original discoveries on its own. However, this statistical power will be useless without an analysis able to guarantee robustness against systematic effects, which the PI of this proposal is an expert on. For this reason, she was invited by the SPT collaboration to lead this effort, opening a unique opportunity of European access to the SPT-3G data. NEUCosmoS will provide a framework to transform the existing SPT-3G pipeline into one with quality comparable to satellite missions, building upon the PI’s Planck experience and tools, adapting them to the new challenge. The NEUCosmoS team will drive the interpretation of current and future hints of new physics in a reliable way, with statistical power comparable to the Planck satellite, and in combination with it, almost doubling the constraining capability. This will pave the way to a future contribution by Europe to the next-generation of CMB experiments.
Progress in the Total Synthesis of Rocaglamide

The first cyclopenta[b]benzofuran derivative, rocaglamide, from Aglaia elliptifolia , was found to exhibit considerable insecticidal activities and excellent potential as a therapeutic agent candidate in cancer chemotherapy; the genus Aglaia has been subjected to further investigation. Both the structural complexity of rocaglamide and its significant activity make it an attractive synthetic target. Stereoselective synthesis of the dense substitution pattern of these targets is a formidable synthetic challenge: the molecules bear five contiguous stereocenters and cis aryl groups on adjacent carbons. In past years of effort, only a handful of completed total syntheses have been reported, evidence of the difficulties associated with the synthesis of rocaglate natural products. The advance on total synthesis of rocaglamide was mainly reviewed from intramolecular cyclization and biomimetic cycloaddition approach.
PROJET DE MARKETING NUMÉRIQUE POUR FORMA.LAB SRL

FORMALAB ÃŠ EST UNE ENTREPRISE DE SERVICES SPÉCIALISÉE DANS LA FORMATION DES RESSOURCES HUMAINES QUI OPÈRE SUR L’ENSEMBLE DU TERRITOIRE NATIONAL.
SUPPORT FOR LAYING OR SITTING DOWN

The inventive support for laying or sitting down has two tubes filled with a fluid, said tubes extending in a longitudinal direction. Transversal rods are guided on said tubes in such a way that they are able to move back and forth in the direction of load application. A padding is arranged on said transversal rods, said padding extending over the tubes from one side of the support to the other.
RADIAL ROLLER BEARING, IN PARTICULAR A CYLINDRICAL OR NEEDLE ROLLER BEARING COMPRISING HOLLOW ROLLERS CONSISTING OF A SHAPE MEMORY ALLOY AND ACTING AS SPACERS

The invention relates to a radial roller bearing (1), in particular a cylindrical or needle roller bearing. Said bearing essentially consists of an outer bearing ring (2) and an inner bearing ring (3), in addition to a number of rolling bodies (4) that are located between the bearing rings (2, 3) and that roll along races (9, 10) of the outer (2) and inner bearing ring (3), said races being delimited laterally by two respective continuous rims (5, 6 and 7, 8). The rolling bodies are guided in relation to one another by rollers that are spaced at uniform intervals. According to the invention, the rollers are formed by individual hollow rollers (11) consisting of a shape memory alloy, each of said rollers being located between two rolling bodies (4). The cross-section of the rollers is deformed during the assembly of the radial roller bearing (1) to fit the dimensions of the free space (12) between one rim (6) of the outer bearing ring (2) and a rim (8) of the inner bearing ring (3) and the rollers can be introduced into the radial roller bearing (1) through the free space (12) between said rims (6, 8) of the bearing rings (2, 3). After introduction into the radial roller bearing (1) and once they have reached a specific temperature, the rollers independently regain their original shape.
BATTERY CELL MODULE, METHOD FOR OPERATING A BATTERY CELL MODULE AND BATTERY AND MOTOR VEHICLE

The invention relates to a battery cell module, which comprises a plurality of battery cells (10), in particular lithium ion battery cells, which each have a ventilation opening (13), and further comprises a gas accommodation chamber (21) which is assigned to a plurality of battery cells (10) to at least temporarily accommodate gas which has escaped from said battery cells (10). According to the invention, the volume of the gas accommodation chamber (21) is connected directly to the ventilation openings (13). The invention also relates to a method for operating a battery cell module, to a battery and to a motor vehicle having the battery cell module or the battery.