SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Production and characterization of endocrine cells derived from human pancreas organoids for the cell-based therapy of type 1 diabetes

Self-renew and multilineage potential characterize stem cells.  We have recently described that pancreas progenitor cells extracted from adult donors can be expanded long-term in vitro into 3D structures, which we have termed organoids.  Pancreas organoids reproduce in vitro all the features of pancreas ductal epithelia, and have a limitless expansion potential.  Thus, pancreas organoids promise to boost cell therapy of type 1 diabetes.  We have recently observed that progenitor cells organoids preserve their genetic stability over a long time in culture. That represents an advantage, when compared to iPS or hES derived approaches, where genetic instability raises concerns for their future therapeutic applications.  While progenitor organoids are promising for the future of cell therapy, bringing stem cell-based therapies to patients requires a reliable characterization (“knowing what the cells do and how they do it”, i.e. a phenotypic and molecular biology characterization), chemically well-defined culture media, and the capacity of mass-production under GLP/GMP conditions.
The LSFM4LIFE consortium aims to the mass production of pancreas organoids for the cellular therapy of type 1 diabetes.  The goals of the project are: (1) optimize growth and differentiation of human pancreas stem-cell organoids by employing phenotypic and molecular high-throughput screening (2) standardize the growth and differentiation of the organoids under well-defined biochemical conditions, and (3) achieve GLP/GMP-production of the human organoids for preclinical studies and phase I clinical studies.  The close collaboration in the consortium between academic researchers and industry, as well as its cross-disciplinary composition, are essential to realize the goals of the project.  The work packages of the project will have a technological impact in the form of patents and first market replication.
A novel micronucleus in vitro assay utilizing human hematopoietic stem cells

The induction of micronucleated reticulocytes in the bone marrow is a sensitive indicator of chromosomal damage. Therefore, the micronucleus assay in rodents is widely used in genotoxicity and carcinogenicity testing. A test system based on cultured human primary cells could potentially provide better prediction compared to animal tests, increasing patient safety while also implementing the 3Rs principle, i.e. replace, reduce and refine. Hereby, we describe the development of an in vitro micronucleus assay based on animal-free ex vivo culture of human red blood cells from hematopoietic stem cells. To validate the method, five clastogens with direct action, three clastogens requiring metabolic activation, four aneugenic and three non-genotoxic compounds have been tested. Also, different metabolic systems have been applied. Flow cytometry was used for detection and enumeration of micronuclei. Altogether, the results were in agreement with the published data and indicated that a sensitive and cost effective in vitro assay to assess genotoxicity with a potential to high-throughput screening has been developed.
NETWORK SERVICE DESCRIPTOR SUPPORT FOR NETWORK SLICE ISOLATION REQUIREMENTS

A non-transitory computer readable media, methods, system and network function virtualization orchestrator can be used to instantiate a network service operating as at least a portion of a network slice. A network service descriptor describing the network service comprises at least one service deployment flavor; zero or more sharing allowed attribute defining if the network service or constituent instances of the network service is allowed to be shared with another network service instance, or with its constituent instances; and zero or more external placement rule attribute defining if the network service or constituent instances of the network service, is affine or anti-affine with current and future other network service or constituent instances of the current and future other network service.
Cancer bioengineered novel microtissues unraveling cancer plasticity

Triple Negative Breast Cancer is the most aggressive among breast cancer subtypes. The conventional neo-adjuvant therapy is ineffective in about 50% of cases, with patients presenting a higher risk of recurrence and metastasis. The failure of the currently available chemotherapeutic strategy is also due to the lack of cancer preclinical models that are “close-to-reality” and therefore able to accurately recapitulate the tumor microenvironment, the transcriptional reprogramming and the cancer cells plasticity of patients with poor outcomes. Currently, miRNAs and lncRNAs are believed to be key components in all major adaptation pathways and involved in the transcriptional reprogramming that occurs after TNBC treatment with neo-adjuvant therapy. Moreover, bioengineered preclinical in vitro models permit to study the molecular mechanisms underpinning adaptive responses to chemotherapy by selecting transcriptional phenotypes that somehow make tumor cells tolerant to drugs, without requiring a selection of genetic features. 
The CONTACT project aims at developing a 3D bioengineered TNBC in vitro model able to shed light on the mechanisms of tumor cells reprogramming that trigger drug-tolerance. The model will include stromal components along with cancer cells and represent an important tool in studying the role of the stroma in transcriptional reprogramming. Bioengineered 3D breast cancer in vitro models will accelerate the establishment of personalized treatment protocols that take into account what exactly, in each patient, leads to transcriptional reprogramming. The CONTACT project will boost the scientific career of the experienced researcher and will lead her to an independent role in research. The project will also broad the expertise of the experienced researcher in the area of cancer genomics. Her expertise in 3D tumor models will pave the way for a new research line in the scientific portfolio of the host institution.
Foodsafety4Eu - multi-stakeholder platform for food safety in europe

FOODSAFETY4EU is a Project focused to design, develop and release a multi-stakeholder platform for the future European Food Safety System (FSS), by structuring a participatory process, which sustains a responsive and adaptive community of FSS actors. 
The platform will enable the FSS actors to access efficiently resources and data, synchronize food safety research strategies, share and exchange scientific knowledge and contributions for the future EU FSS. It will boost interactive cooperation within the system and with the civil society for enhancing public confidence through dedicated tools. 
A European Food Safety Forum will be set up to officially consolidate the participatory process and guarantee the long term science-policy-society interface. New digital tools, co-designed strategies and communication models will support Food Safety Authorities (FSAs), EU Agencies, policy makers, scientists and civil society in a coordinate approach, thus contributing to strengthen the EU approach to risk assessment & communication. 
The multi-actor consortium is pooled by a core group of 23 partners from 12 countries: scientific experts in food safety will work closely with key actors with complementary knowledge in:
a) developing and structuring of participatory processes; 
b) stakeholders engagement, communication and networking; 
c) e-platforms, smart tools, data management; 
d) Food Safety policies implementation; 
e) representing the voices from food and feed industry, consumers and the civil society. 
A network of other 44 Food Safety actors – engaged as “Supporting partners” – are committed to populate the platform and interact by expressing opinions, sharing information, data and reports; providing strategy advice and assuring a multiplier impact of project results.
PANIFICIO ROTONDO S.R.L.

LA RINNOVATA RICHIESTA DA PARTE DEI CLIENTI HA DETERMINATO UNA INSUFFICIENZA DELLE PREESITENTE STRUTTURA PRODUTTIVA, RICHIEDENDO PERTANTO IMPORTANTI INVESTIMENTI VOLTI AD INCREMENTARE LA CAPACITA' PRODUTTIVA E A RIDURRE I TEMPI DI PRODUZIONE, I COSTI ENERGETICI E AUMENTARE LA QUALITA' DEI PRODOTTI. IN PARTICOLARE, I DUE NUOVI FORNI (UNO DEI QUALI GIA' ACQUISTATO) CONSENTIRANNO ALL'IMPRESA IL RAGGIUNGIMENTO DEI SOPRA DESCRITTI OBIETTIVI. LE ALTRE ATTREZZATURE (IMPASTATRICI, LAVATEGLIE, MESCOLTATRICE E ALTRE MINORI) ANDRANNO A COMPLETARE L'INTERVENTO, UNITAMENTE AL RINNOVO DELL'ARREDAMENTO DI TUTTI E TRE LE UNITA' LOCALI. INFINE, A GARANZIA E TUTELA DELLA PRODUZIONE, SARA' INSTALLATO UN SISTEMA DI VIDEOSORVEGLIANZA NELLE UNITA' DI VIA COLOMBO 24, NOLI E P.ZZA COLOMBO 5, SPOTORNO DOVE E' ANCORA MANCANTE RISPETTO ALL'UNITA' DI P.ZZA RONCO 1 A NOLI.
Morphologic, functional, and occlusal characterization of mandibular lateral displacement malocclusion

Mandibular lateral displacement (MLD) is clinically characterized by deviation of the chin, facial asymmetry, dental midline discrepancy, crossbite in the posterior region, and high prevalence of internal derangement of the temporomandibular joint. Morphologic and functional characteristics of MLD should be clarified to correct and prevent this malocclusion.We examined the morphologic features, occlusal scheme, and functional behavior of MLD in 116 patients. Facial morphology was examined with posteroanterior cephalograms, occlusion guidance on the articulator after face-bow transfer, and condylar movement with the condylograph.The superiorly inclined occlusal plane was associated with mandibular deviation in the same direction. The posterior occlusal plane on the shifted side was significantly steeper than that on the nonshifted side. Functional analysis of condylar movement showed a close relationship between the direction of MLD and the direction of condylar lateral shift during opening and closing, and protrusion and retrusion. The occlusal guidance inclination in the buccal segment of the nonshifted side was steeper than that in the shifted side.The results suggested that reduced vertical height of the dentition on 1 side induced mandibular lateral adaptation with contralateral condylar shift (asymmetry); this leads to condylar lateral shift during functional movement.
Transferring Energy Efficiency to the Mediterranean Schools

The target of the EU of reducing by 20% its total emissions within 2020 has activated actions both in private and public sector. Renovation of buildings emerges as an urgent issue, but there is lack of knowledge on performance/cost characteristics of advanced component and systems for efficient renovation of buildings. Moreover, while incentives are given to private sector, Local Authorities face severe limitations of budget. TEESCHOOLS aims at providing new solutions to Local Authorities both in technical and financial terms to implement Nearly Zero Energy Building (NZEB) renovation activities in Mediterranean Schools. The innovative approach consists in setting up an integrated set of user friendly but scientifically sound tools: a pre-audit tool for simplify the energy audits, a carbon footprint calculator based on the building life cycle information, an innovative database of BAT for renovation of school buildings; tailored financing models and highly qualified trainings. These tools will be tested in all partner countries and will be adapted and harmonized with the objective to be used in local, regional and national energy plans. An expert transnational working team will support the pilots and blended learning models will help enhancing capacity in public sector. The transnational and multidisciplinary expertise of the partnership will be a fundamental asset to consolidate the knowledge of local energy managers.
Evaluating Palliative Care Needs in Middle Eastern Countries

Cancer incidence in Middle Eastern countries, most categorized as low- and middle-income, is predicted to double in the next 10 years, greater than in any other part of the world. While progress has been made in cancer diagnosis/treatment, much remains to be done to improve palliative care for the majority of patients with cancer who present with advanced disease.To determine knowledge, beliefs, barriers, and resources regarding palliative care services in Middle Eastern countries and use findings to inform future educational and training activities.Descriptive survey.Fifteen Middle Eastern countries; convenience sample of 776 nurses (44.3%), physicians (38.3%) and psychosocial, academic, and other health care professionals (17.4%) employed in varied settings.Palliative care needs assessment.Improved pain management services are key facilitators. Top barriers include lack of designated palliative care beds/services, community awareness, staff training, access to hospice services, and personnel/time. The nonexistence of functioning home-based and hospice services leaves families/providers unable to honor patient wishes. Respondents were least satisfied with discussions around advance directives and wish to learn more about palliative care focusing on communication techniques. Populations requiring special consideration comprise: patients with ethnic diversity, language barriers, and low literacy; pediatric and young adults; and the elderly.The majority of Middle Eastern patients with cancer are treated in outlying regions; the community is pivotal and must be incorporated into future plans for developing palliative care services. Promoting palliative care education and certification for physicians and nurses is crucial; home-based and hospice services must be sustained.
Road Sector Development and Economic Growth in Ethiopia

The study attempts to see the trends, stock of achievements, and impact of road network on economic growth in Ethiopia. To do so, descriptive and econometric analyses are utilized. From the descriptive analysis, the findings indicate that the stock of road network is by now growing at an encouraging pace. The government’s spending has reached tenfold relative to what it was a decade ago. It also reveals that donors are not following the footsteps of the government in financing road projects. The issue of rural accessibility still remains far from the desired target level that the country needs to have. Regarding community roads, both the management and accountancy is weak, even to analyze its impact. Thus, the country needs to do a lot to graduate to middle income country status in terms of road network expansion, community road management and administration, and improved accessibility. The econometric analysis is based on time series data extending from 1971‐2009. Augmented Cobb‐Douglas production function is used to investigate the impact of roads on economic growth. The model is estimated using a two‐step efficient GMM estimator. The findings reveal that the total road network has significant growth‐spurring impact. When the network is disaggregated,  asphalt road also has a positive sectoral impact, but gravel roads fail to significantly affect both overall and sectoral GDP growth, including agricultural GDP. By way of recommendation, donors need to strengthen their support on road financing, the government needs to expand the road network with the aim of increasing the current rural accessibility, and more attention has to be given for community road management and accountancy. Lastly, gravel road expansion has to be made to meet the target level of the road network and simultaneously ascertain rural accessibility, thereby improving agricultural productivity and market access of the poor rural population. Keywords: Road sector development, Stock of achievements, Impact on Overall and Sectoral Economic Growth, Two‐step GMM Estimation, Ethiopia
BALL BEARING

The invention relates to a ball bearing (1) provided with a bearing ring (3,4) and a cage (5, 35), in addition to at least one run-on surface (15) which is mounted on the bearing ring (3,4). The cage (5, 35) is provided with pockets (9, 41) which are adjacent to each other and which are arranged on the side of the periphery around the rotational axis (1a, 35a) of the ball bearing (1). Each pocket (9, 41) is defined in a demodulated axial first direction of the first edge (11, 36) by means of the axis of rotation (1a, 35a), in addition to being at least partially defined in at least one second direction of the second edge (12, 37) which is counter to the first direction, and at least one of the edges (11, 12, 36, 37) is defined in a radial direction by a radial guide surface (14, 45), whereby the guide surface (14,45) lies opposite the run-on surface (15) in at least a radially defined manner.
Craft Lab- Residences on the way from products to the Adri-Ionian design

Mosaic, fabric, ceramic: promoting common artistic heritage of Puglia and Greece through youth entrepreneurship!
These are the main areas of interest of Craft Lab project, that aims to promote entrepreneurial spirit in the young and creation of start-up through the rediscovery of ancient professions and crafts in the fields of ceramics, mosaics and fabrics, giving value to the cultural identity of Puglia and the Ionian Islands. Young artists and designers, art professionals and "craft angels" will be the protagonists of the "experience labs", itinerant creativity laboratories set up in 6 residences between Puglia and the Ionian Islands in Greece, aimed to combine traditional craftsmanship with technology and design, by blending in a synergetic way the arts of the past with the modern innovations.
Hierarchical multiscale modeling of flexoelectricity and related materials properties from first principles

Flexoelectricity, the coupling between an inhomogeneous deformation and the electrical polarization, has emerged a “hot” topic in modern materials science due to its cross-cutting relevance to many phenomena of fundamental and technological interest. Understanding the intriguing physics that governs its behaviour at the nanoscale is crucial to harnessing the potential of strain gradients in practical applications, and such a progress requires a substantial support from theory. In spite of impressive recent advances, first-principles calculations of flexoelectricity remain technically challenging at several levels: first, the breakdown of translational lattice periodicity that a strain gradient entails is problematic to treat in the context of traditional electronic-structure methods; second, the stringent length- and time-scale constraints of direct quantum-mechanical approaches limit the applicability of these methods to real problems, which often involve complex sample shapes and morphologies. This project is aimed at overcoming these obstacles from their very root, via the development of ground-breaking innovations in electronic-structure and multiscale methodologies, and at using these advances to address a number of pressing physical questions in the context of energy and information technologies. In particular, the objectives of this project are: (i) identifying the microscopic mechanisms that are most effective at delivering a strong flexoelectric response in a variety of materials; (ii) understanding how these bulk effects are modified by size, shape and boundary conditions, and how they interact with other material properties; (iii) supporting the experimental interpretation by critically assessing alternative physical interpretations of the observed effects (e.g. compositional gradients); (iv) exploring the functionalities enabled by strain gradients in complex materials systems, including 2D crystals, semiconductor nanowires and multiferroics.
Co-Production of seasonal representations for adaptive institutions

Climate change may be undermining the stock of seasonal representations that society draws on to understand and live according to the weather. The CALENDARS project studies how modern society represents seasons, and how these representations shape institutions and help people live with seasonal change. The project opens an important emerging field in climate adaptation research by examining the representations of ‘normal’ seasons underlying key institutions, assesses their quality for successful adaptation to rapid climate change, and analyses facilitators and barriers to adopting representations more flexibly to new climates. It contributes a novel perspective on how to transform our institutions – from schools to farmer cooperatives – from the foundational culture and representations up, to better fit the changing seasonal cycles we are experiencing.

CALENDARS empirically explores the relationship between different institutions’ ideas of seasons and their successful adaptation through an in-depth comparative study of a set of institutions in two local communities, in Norway and New Zealand. It is steered by an overall objective to: ‘Advance knowledge and understanding of how seasonal representations shape and are shaped by institutions, and critically appraise the quality of these representations for contributing to successful adaptation to seasonal change’. 

Conceptually, CALENDARS looks at representations as continuously ‘co-produced’ at the boundary of nature and society, and society and institutions. It tests a novel reconceptualisation of co-production as a prism; with each of the project’s three phases looking at the complex processes by which representations emerge through different ‘lenses’ of co-production. Methodologically, the project tests the feasibility of a novel basket of bespoke methods spanning narrative interviews, calendar boundary objects and collaborative sustainability science.
A highly innovative size recommendation engine, disrupting the existing online apparel market by using big data and machine-learning algorithms.

Fit Analytics GmbH is a Berlin-based ICT-SME, operating in the online fashion market. We are aiming to solve the two major
problems of online fashion retail:

1. High return rates (~40-50%) because many end users don’t know their size. ~65% of all returns are made due to non-fit.
High return rates have certain side effects, e.g. enormous CO2 emissions.
2. Low conversion rates to buy (less than 2% of all visitors convert into buyers; this is significantly lower compared to books
or electronics sold online) because end users are uncertain which size to buy. Today, only 9% of all garments are sold online
and 91% are still sold in brick-and-mortar stores, whereas more than 50% of all books and electronics are sold over the internet.

We have already deployed the world’s most widely-used Size Advisor (“FITA1.0”) in the market, an innovative ICT product to
help end-users find the right size online by providing simple size recommendations. Within the framework of the SME
Instrument, Phase II, we are aiming to implement a new, ground-breaking size and product recommendation solution (“FITA2.0”) which will further disrupt the fashion retail market by using exclusive cross-shop purchase and return data for highly accurate size and personalized product recommendations.

We have already developed a minimal viable product (MVP) of FITA2.0 that was successfully tested in an operational
environment (TRL6) on Gaastra, a leading Dutch-German brand.We have undertaken a commercial and technical feasibility study, with positive results, and this will form the basis for a business implementation plan to be created during the project. In order to accelerate the market acceptance of the solution after implementation, we have already signed contracts with several clients that have agreed to implement FITA2.0 in the future.

The project is closely related to the objectives of the call due to its disruptive character and planned market uptake.