SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Self-organized internal architectures of chiral micro-particles

The internal architecture of polymeric self-assembled chiral micro-particles is studied by exploring the effect of the chirality, of the particle sizes, and of the interface/surface properties in the ordering of the helicoidal planes. The experimental investigations, performed by means of different microscopy techniques, show that the polymeric beads, resulting from light induced polymerization of cholesteric liquid crystal droplets, preserve both the spherical shape and the internal self-organized structures. The method used to create the micro-particles with controlled internal chiral architectures presents great flexibility providing several advantages connected to the acquired optical and photonics capabilities and allowing to envisage novel strategies for the development of chiral colloidal systems and materials.
One stage, full-mouth, ultrasonic debridement in the treatment of severe chronic periodontitis in smokers: a preliminary, blind and randomized clinical trial.

The aim of this clinical trial was to assess the performance of a full-mouth ultrasonic debridement protocol in the treatment of severe chronic periodontitis in comparison with scaling and root planing in a quadrant-wise procedure in smokers.The trial consisted of 30 participants presenting with periodontitis divided into 3 groups: Group FMUD - full-mouth ultrasonic debridement, i.e., one session of 45 minutes of ultrasonic instrumentation for smokers (n = 10), Group SRP- scaling and root planing performed in a quadrant-wise manner for smokers (n = 10), and Group Control - SRP for nonsmokers (n = 10), treated following the same protocol as the SRP group. The parameters evaluated were: plaque/bleeding on probing indices, probing pocket depth, relative recession, and relative probing attachment level at baseline, 45, 90 and 180 days after therapy.Full-mouth ultrasonic debridement and scaling and root planing resulted in comparable gain of attachment 6 months after therapy. Both groups exhibited probing pocket depth reduction at all experimental periods as compared to baseline. Smokers, however, had less probing pocket depth reduction and relative probing attachment level gain compared to non-smokers, despite the mechanical protocol used (p < 0.05). Moreover, at 180 days, nonsmokers presented with fewer sites requiring re-treatment (probing pocket depth > 5 mm and bleeding on probing) than smokers (p < 0.05).Full-mouth ultrasonic debridement and scaling and root planing result in comparable clinical outcomes for the treatment of smokers with severe chronic periodontitis. Despite the non-surgical technique used, smokers had a less favorable clinical response than non-smokers.
Intermediäre, Konventionen und die Diskurse des Arbeitsmarktes

In diesem Text soll an eine Pionierarbeit zu den Diskursen des Arbeitsmarktes angeknüpft werden, die die empirische Analyse von Stellenanzeigen und des Systems der Berufsbezeichnungen unternommen hat (Bessy et al. 1999). Diese Analyse setzte bei den Informationsdispositiven an, die durch die involvierten Akteure mobilisiert wurden. Das Ausgangsinteresse war, die verschiedenen Register der Qualifizierung2 der Arbeit und der sich bewerbenden Personen sowie die Pluralität der Konventionen („Grammatiken“) für die Evaluation der Kompetenzen herauszustellen.3 Diese Arbeit zu den Stellenanzeigen und den Berufsbezeichnungen steht im Kontext des Forschungsansatzes der „Economie des conventions“ (englisch "economics of convention", im Folgenden kurz EC), welche in Frankreich seit den 1980er-Jahren entwickelt worden ist, um die Analyse von Institutionen zu erneuern.
MiR-494 is regulated by ERK1/2 and modulates TRAIL-induced apoptosis in non–small-cell lung cancer through BIM down-regulation

MicroRNAs (miRNAs) have an important role in the development of chemosensitivity or chemoresistance in different types of cancer. Activation of the ERK1/2 pathway is a major determinant of diverse cellular processes and cancer development and is responsible for the transcription of several important miRNAs. Here we show a link between the ERK1/2 pathway and BIM expression through miR-494. We blocked ERK1/2 nuclear activity through the overexpression of an ERK1/2 natural interactor, the protein PED/PEA15, and we performed a microRNA expression profile. miR-494 was the most down-regulated microRNA after ERK1/2 inactivation. Moreover, we found that miR-494 induced Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) resistance in non-small-cell lung cancer (NSCLC) through the down-modulation of BIM. Elucidation of this undiscovered ERK1/2 pathway that regulates apoptosis and cell proliferation through miR-494 in NSCLC will greatly enhance our understanding of the mechanisms responsible for TRAIL resistance and will provide an additional arm for the development of anticancer therapies.
Educational ecosystems: a research model applied in four Italian territories of the Tuscany Region

The article presents the OLESchool research, which conducted a feasibility study aimed at the definition of an integrated learning ecosystem model in which the school system becomes the focus of an open learning environment. The research considered the criticalities, priorities and limitations related to the pandemic event, highlighting the resources and opportunities generated, and aimed to identify those success factors and criteria for building prototypes and hypotheses of expected results to be implemented at a subsequent stage. The research adopted a collaborative approach starting with the stakeholder engagement process. The research team applied a methodological design inspired by the Grounded Theory paradigm, studying the phenomenon holistically from different points of view with qualitative-quantitative parallel research phases and triangulation between researchers, theories, data and tools. The contribution presents the results, distinguished between output and outcome of the research.&#x0D; &#x0D; Ecosistemi educativi: un modello di ricerca applicato in quattro territori della Toscana.&#x0D; Il contributo presenta la ricerca OLESchool che ha visto la realizzazione di uno studio di fattibilità volto alla definizione di un modello di ecosistema formativo integrato dove il sistema scolastico diventa fulcro di un ambiente di apprendimento aperto. Sono state tenute in considerazione criticità, priorità e vincoli relativi all’evento pandemico, facendo emergere le risorse e le opportunità scaturite e puntando all’individuazione di quei fattori di successo e criteri di costruzione di prototipi e ipotesi di risultati attesi da implementare in una fase successiva. La ricerca ha seguito un approccio di tipo collaborativo a partire dal processo di stakeholder engagement. È stato adottato un disegno metodologico ispirato al paradigma della Grounded Theory, studiando il fenomeno in modo olistico da punti di vista differenti, con fasi di ricerca parallele quali-quantitative e trasversali di triangolazione tra ricercatori, teorie, dati e strumenti. Nel contributo sono presentati i risultati distinti tra output e outcome della ricerca.
Next generation composite material heating

Flexible heating systems are used in numerous applications such as the heating of Industrial sized liquid tanks, to de-icing chiller units. However, they are based on silicon with non-optimal thermal conductivity and resistive wire elements. The result is restricted flexibility and low efficiency. OHMVO was a company created to find a solution for the numerous clients frustrated with this solution.

We have designed and are patenting a thermally improved and conductive silicon. Highly efficient and flexible, aside from external heating of irregular surfaces, for the first time our product will deliver embedded heating, heating from within a uniform, or complex shaped component.

We request phase 1 funding to allow us to complete a prototype demonstration with a potential client and to investigate and select the first applications to target for market entry. 

With multiple clients already interested and the possibility to drive many new breakthrough applications we are predicting revenues of 16.45M and 32 employees by 2026.
Triunia kittredgei P.M.Olde (Proteaceae: Grevilleoideae: Roupaleae), a new name for Triunia robusta sensu D. Foreman misapplied

The name Triunia kittredgei P.M. Olde replaces Triunia robusta sensu D. Foreman (1986) following an invalid lectotypification. Triunia erythrocarpa Foreman is referred to synonymy under Triunia robusta, correctly applied. The lectotypes of T. robusta and T. montana were apparently not distributed to NSW as indicated by Sleumer (1955) and replacements are here redesignated from among the existing isolectotypes. The holotype of Triunia youngiana was not collected by Charles Moore as indicated by Moore and Mueller (1864), and Sleumer (1955) who typified the name with Moore’s collection number 4 at MEL. The evidence points to the collection Richards 4 as the holotype.
A diplomacia pontifícia e os refugiados judeus no Brasil (1939-1941): uma investigação preliminar nos arquivos de Pio XII

O artigo analisa o papel da diplomacia pontifícia nas negociações entre o Vaticano e o governo de Getúlio Vargas para a concessão de vistos a refugiados judeus convertidos ao catolicismo (“católicos não arianos”) entre 1939 e 1941. Utilizando os arquivos do pontificado de Pio XII, abertos em março de 2020, e dialogando tanto com a historiografia brasileira a respeito das políticas migratórias quanto com a historiografia europeia recente dedicada ao catolicismo, a pesquisa pretende contribuir para o aprofundamento do debate acerca do papel da Igreja na questão dos refugiados judeus no Brasil.
Innovative tool for personalized treatment of patients with neovascular age-macular degeneration: dosage optimization for long term efficacy treatment

With the ageing population, visual threatening illnesses are increasing. For instance, age-related macular degeneration (AMD) is expected to affect almost 25 million Europeans by 2040. The AMD treatment consists in regular injections of the anti-VEGF therapeutic drug (Lucentis, Avastin, Eylea) into the eye ball, vitreous, for the rest of the patient life. However, the dosing intervals varies widely among the patients and there is no a clear consensus or quantitative method for evaluating the injection frequency. For that, computational tools linking the drug dose regimen and the drug effect in the retina are needed. However, such pharmacokinetic-pharmacodynamic models are still missing. Combining population pharmacokinetic and optical coherence tomography (OCT) imaging technique is a new, novel and promising approach. The drug effect can be evaluated non-invasively, measuring the central macular thickness in the retina scan. The models generated will allow appropriate individualized dosing regimen to the patients in clinics that will be anticipated from individual retina scan determinations with OCT. 
The optimization and personalization of dosing regimen will ensure an efficient long-lasting treatment, improving patient quality of life while reducing the burden to the health care system. Moreover, the models will increase our understanding in the treatments, constitute a pioneer tool in effect assessment in ocular therapeutic field and a first step towards more advanced ophthalmic models. The candidate has strong expertise in intravitreal pharmacokinetic and this project will advance her into clinical pharmacodynamic modelling at the renowned Centre for Applied Pharmacokinetic Research, University of Manchester. The inter-disciplinary and inter-sectoral character of the project will definitely benefit her career development as a researcher.
Molecular Biology of Hearing and Balance

The senses of hearing, balance, and touch all rely on mechanorecep­tors, as do the proprioceptive sensations that indicate an organism how it is situated within the environment. Mechanoreception is probably one of the most ancient of the senses with mechanosensitivity existing in every type of organism in all three domains for example, Bacteria, Archaea, and Eukarya. Hair cells are the sensory cells of the internal ear, essential for the senses of sound and balance. The hair cell's transduc­tion apparatus, the molecular machinery that converts forces and displacements into electrical responses, can respond to mechanical stimuli of less than 1 nm in amplitude and tens of kilohertz in frequency. Indeed, our hearing is ultimately lim­ited by Brownian motion of water molecules impinging on the transduction apparatus. In multicellular organisms, mechanoreceptors are either neurons or neuroepithelial cells with synapses that allows the cells to stimulate other neurons. In vertebrates, hair cells are used in the inner ear's balance and hearing organs; in amphibians and fish, hair cells also are the mechanoreceptors of the lateral line that detects the nearby fluid movement.
Pretreatment methods for aquatic plant biomass as carbon sources for potential use in treating eutrophic water in subsurface-flow constructed wetlands

Plant biomass is usually added to constructed wetlands (CW) to enhance denitrification. In this study, we investigated effects of different pretreatments on two common external plant carbon sources, cattail and reed litter. We determined the average ratio of chemical oxygen demand (COD) to total nitrogen (TN), designated as C/N, in water samples after addition of litter subjected to various pretreatments. The C/N in the water samples ranged from 4.8 to 6.4 after addition of NaOH-pretreated cattail litter, which was four to six times greater than that of water from the Yapu River and 3.84–39.15% higher than that of systems that received untreated cattail litter. The C/N of systems that received H2SO4-pretreated carbon sources varied from 1.7 to 3.6. These two methods resulted in TN and total phosphorus (TP) levels lower than those in river water. The C/N was 1.4–1.7 after addition of CH3COOH-pretreated reed litter, which was 34.87–53.83% higher than that of river water. The C/N was 2.5 in systems that received mild alkali/oxidation-pretreated reeds, which was 30.59% higher than that of systems that received non-pretreated reeds. The residue rates of cattail and reed litter subjected to various pretreatments were greater than 60%. Our results showed that NaOH, H2SO4, and mild alkali/oxidation pretreatments were useful to rapidly improve the C/N of river water and enhance denitrification.
How will coral reefs look like in the future? adaptive mechanisms and sublethal effects in corals under global change

Coral reefs are among the most diverse, spectacular and productive ecosystems on the planet. However, coral reefs are also among the marine ecosystems more susceptible to the adverse effects of the on-going global change. The frequency and severity of coral bleaching and mass mortality events increases every year, with serious consequences on the long-term viability of coral populations. However, during the last years, few studies have investigated the future of coral populations under different global change scenarios using demographic models. Moreover, these studies have not considered the capacity of corals to adjust their physiology to maintain performance despite environmental change (acclimatization) with the additional energetic cost of this adaptive mechanisms and their consequent transgenerational effects on the viability of future offspring. The CoralChange project will investigate, for the first time, the transgenerational effects induced by global change in stony coral and octocoral species in order to determine how their population dynamics and viability is compromised in the long-term. To achieve this goal, I will develop demographic predictive models combining field and experimental data that include coral physiological condition, trophic plasticity, reproductive success and larval viability. This new approach will identify the possible energetic costs of adaptive mechanisms to ocean warming and acidification that may undermine the early, and most vulnerable, life stages of corals. The results of this study will be essential to develop effective management and conservation strategies to safeguard coral reefs under multiple stressors, as well as identify coral species and populations with higher probability to survive in future conditions.
Robert DARNTON, «La poesía y la policía. Las redes de comunicación en el París del siglo XVIII», pról. Íñigo Lomana, trad. Eduardo Saborit, Madrid, Clave intelectual, 2021, 245 págs.

Sin resumen.
Swallowable Wireless Capsule Endoscopy: Progress and Technical Challenges

Wireless capsule endoscopy (WCE) offers a feasible noninvasive way to detect the whole gastrointestinal (GI) tract and revolutionizes the diagnosis technology. However, compared with wired endoscopies, the limited working time, the low frame rate, and the low image resolution limit the wider application. The progress of this new technology is reviewed in this paper, and the evolution tendencies are analyzed to be high image resolution, high frame rate, and long working time. Unfortunately, the power supply of capsule endoscope (CE) is the bottleneck. Wireless power transmission (WPT) is the promising solution to this problem, but is also the technical challenge. Active CE is another tendency and will be the next geneion of the WCE. Nevertheless, it will not come true shortly, unless the practical locomotion mechanism of the active CE in GI tract is achieved. The locomotion mechanism is the other technical challenge, besides the challenge of WPT. The progress about the WPT and the active capsule technology is reviewed.
HERMETICALLY SEALED CONTAINER WITH DROP CONTROL

A hermetically sealed container for liquid contents occluded by a pierceable top and a separate dispensing cap threaded over the container and including a spike that defines a through passageway which terminates in a dispensing nozzle at one end and a pointed piercing tip at the other end. The piercing tip defines a pair of spaced apertures for dispensing drops of uniform, repeatable, and controllable size through the dispensing nozzle.
Medalhão setecentista italiano com efígie de Cristo e moldura em metal dourado do Palácio Nacional da Ajuda, Lisboa

O presente texto aborda uma peça inédita: um medalhão setecentista, de produção italiana, que consiste numa efígie relevada de Cristo, em mármores polícromos, enquadrada por uma moldura oval em metal dourado, constante das colecções do Palácio Nacional da Ajuda (Lisboa). Ao longo do texto procurar-se-á situar cronologicamente a peça bem como clarificar a sua origem italiana.
SELF-PRESERVED AQUEOUS PHARMACEUTICAL COMPOSITIONS

The use of borate/amino alcohol/zinc systems to enhance the antimicrobial activity of multi-dose pharmaceutical compositions is described. The compositions do not require a conventional anti-microbial preservative and therefore are referred to as being "self-preserved". The compositions possess sufficient antimicrobial activity to satisfy the preservative efficacy requirements of the USP for aqueous ophthalmic compositions.
POLYSILOXANE-BASED WATER REPELLANTS FOR TEXTILES

An aqueous emulsion including a discontinuous oil phase comprising: a) a polyorganohydrogensiloxane, b) an amino-modified polyorganosiloxane comprising at least one amino group located at a terminal position and c) a blocked isocyanate.
A SHARIA RETURN AS AN ALTERNATIVE INSTRUMENT FOR MONETARY POLICY

Rapid development in Islamic financial industry has not been supported by sharia monetary policy instruments. This study looks at the possibility of sharia returns as the instrument. Using both error correction model and vector error correction model to estimate the data from 2002(1) to 2010(12), this paper finds that sharia return has the same effect as the interest rate in the demand for money. The shock effect of sharia return on broad money supply, Gross Domestic Product, and Consumer Price Index is greater than that of interest rate. In addition, these three variables are more quickly become stable following the shock of sharia return. Keywords: Sharia return, islamic financial system, vector error correction model JEL classification numbers: E52, G15
Divide and conquer ab initio semiclassical molecular dynamics for spectroscopic calculations of complex systems

Given the continuing revolution in “nano” and “bio” technologies, it is urgent for chemists to be able to carry out reliable quantum dynamics simulations of complex molecular systems. The goal of this project is to fill the gap between theory and experiment and provide the community with a user-friendly computational tool for nuclear spectra (IR, vibro-electronic, etc.) calculations of very complex systems.
Present theoretical methodologies are hampered either by artificial nuclear potential interactions or by local potential perturbation assumptions. The semiclassical molecular dynamics method that I have been pioneering is not affected by these limitations because it is based on ab initio classical trajectories. The nuclear forces can be calculated by any electronic structure software and trajectories can explore the entire potential surface. The remaining challenge is to overcome the exponential scaling of computational power.
I will adopt a divide-and-conquer strategy to beat the curse of dimensionality. Firstly, the ab initio classical molecular dynamics is performed for the entire complex system. Then, partial spectra are calculated by using the semiclassical information derived by the projection of the trajectories onto lower dimensional spaces. Vibrational modes are not artificially decoupled. Finally, the entire spectrum is reconstructed piece by piece. This method allows chemists to have a more reliable spectral interpretation in a wider context up to the nanoscale. With the help of my own previous experience and my collaborations, I will simulate pollutant photodegradation for environmental remediation and the vibro-electronic spectra of carcinogenic molecules adsorbed on TiO2. I will also reproduce the spectroscopic properties of molecular nano-texturing of titania films for outdoor cultural heritage preservation. 
A new generation of semiclassical fellows will be educated to put Europe on the leading edge of quantum simulations for spectroscopy.