SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Phase II trial of continuous once-daily dosing of sunitinib as first-line treatment in patients with metastatic renal cell carcinoma

Sunitinib at 50 mg/day on the 4-weeks-on-2-weeks-off schedule is the current approved regimen for advanced/metastatic renal cell carcinoma (mRCC). Escudier et al reported that continuous, once-daily dosing with sunitinib 37.5 mg had a manageable safety profile and significant antitumor activity as second-line mRCC therapy. In this prospective, multicenter, phase II study, we evaluated the activity of continuous once-daily dosing with sunitinib 37.5 mg as first-line mRCC treatment.One hundred nineteen treatment-naive patients with measurable mRCC received sunitinib. The primary endpoint was objective response; secondary endpoints included progression-free survival (PFS), safety, pharmacokinetic measurements, exploration of response biomarkers, and patient reported outcomes (PRO).Objective response rate (ORR) was 35.3%; median response duration was 10.4 months; 36% of patients had stable disease ≥12 weeks. Median PFS at 1 year was 9 months, and 1-year survival probability was 67.8%. The most common any-grade treatment-related adverse events (AEs) were diarrhea (50%) and hand-foot syndrome (43%); the most common grade 3-4 treatment-related AEs were hand-foot syndrome (13%), neutropenia (11%), and diarrhea (9%). Steady-state pharmacokinetics were reached within 3 weeks, with no disproportionate accumulation of sunitinib or its active metabolite throughout the study. No significant correlations between trough drug, active metabolite, or soluble protein levels and clinical response were observed. PRO was largely maintained, although fatigue appeared to worsen after treatment started, with improvement over time.Continuous once-daily dosing with sunitinib 37.5 mg was active with a manageable safety profile as first-line mRCC therapy, making this a feasible alternative dosing regimen.
Dynamic laser-induced effects in nanocomposite systems based on the cadmium sulfide quantum dots in a silicate matrix

In this paper we study the laser-induced modification of optical properties of nanocomposite based on cadmium sulphide quantum dots encapsulated into thiomalic acid shell which were embedded into a porous silica matrix. It was found that exposure to laser radiation at λ = 405.9 nm leads to modification of optical properties of nanocomposite. For this exposed area there is a significant amount of photodynamic changes under subsequent exposure to laser radiation at λ = 405.9 nm, namely photoabsorption and photorefraction which were studied at λ = 633 nm. The value of these effects dependent on the concentration of quantum dots and modifying radiation parameters. Moreover, it has dependence from polarization of exposure radiation.
Microplastic-Free sulapac-material challenges plastic

The extensive use of plastic in packaging is a growing global challenge. Over 30% of the 78 million tons produced annually ends up polluting our environment. There is not a great alternative for the plastic yet in the mass market: biodegradable bioplastics degrade too slowly and non-biodegradable bioplastics pollute the world with microplastic.

Finnish SME Sulapac has created the most sustainable packaging solution in the world. It is 100% biodegradable and contains 0% microplastics. Sulapac® has all the benefits of plastic, but without the waste problem. The renewable wood-based material has a low carbon footprint, yet it is similar to plastic in terms of price, formability and functionality.

Sulapac® is a fast biodegrading water, oil and oxygen resistant material solution. It is suitable for mass manufacturing of rigid and flexible packaging such as jars and tubes. It can also be used for light weight packaging. Sulapac is a real alternative to plastics used in high-volume cosmetics and food industries. 

The aim of the SULACHANGE project is to finalise our product offering to capture the full potential of our unique material and prepare for global scale market introduction. We will optimise our recipe and barrier coatings for high volume cosmetic and food industries, apply for required certificates, do customer pilots and create a licensing model. As a result of the project, the company will grow to annual revenues of €90 million within a few years.
ELECTRODE COOLING ARRANGEMENT

The invention relates to a collimator electrode, comprising an electrode body (81) that is provided with a central electrode aperture (82), wherein the electrode body defines an electrode height between two opposite main surfaces, and wherein the electrode body accommodates a cooling conduit (105) inside the electrode body for transferring a cooling liquid (102). The electrode body preferably has a disk shape or an oblate ring shape. The invention further relates to a collimator electrode stack for use in a charged particle beam generator, comprising a first collimator electrode and a second collimator electrode that are each provided with a cooling conduit (105) for transferring the cooling liquid (102), and a connecting conduit (110) for a liquid connection between the cooling conduits of the first and second collimator electrodes.
Delivering the 3b generation of lnmo cells for the xev market of 2025 and beyond

3beLiEVe aims at delivering the 3b generation of LNMO cells for the electrified vehicles market of 2025 and beyond. The project addresses the full scope of the LC-BAT-5-2019 call by delivering:

• 3b generation batteries with LNMO cathodes, LiFSI electrolyte, and a 10-20 wt.% Si-C anode in a cell architecture capable of 750 Wh/l, 300 Wh/kg, 1.4 kW/kg, and 2,000+ deep cycles, of which 10% at 3C+;
• a portfolio of internal and external sensors (22 sensors per module) and an adaptive liquid cooling system managed by a smart BMS with advanced diagnostic and operational functions;
• cradle to cradle approach, including cell/module/pack green manufacturing processes (gigafactory level), optical equipment for inline quality inspection, 1st and 2nd life performance and recyclability demonstration, achieving 90 €/kWh life cycle cost.

The project will deliver 250 cells of generation 3b in total and two demonstrator battery packs of 88 cells and 12 kWh capacity each at TRL 6 / MRL 8. These aim at demonstrating the 3beLiEVe technology performance for applications in light duty (i.e. passenger cars, freight vehicles) and commercial vehicles (i.e. city buses and trucks) in fully electric/plug-in hybrid (BEV/PHEV) configurations. 3beLiEVe technology is free of critical raw materials (cobalt and natural graphite), scalable and sustainable, aiming at 12.7 GWh production by 2025 and 33.7 GWh in 2030, for a market ranging from 1.1 to 2.5 billion €/year, i.e. 7% of the global manufacturing capacity. All the technological domains and innovations addressed in 3beLiEVe are essential for strengthening the position of the European battery and automotive industry in the future market of xEVs.
Working capital subsidy for MATECS sp. z o.o.

The project concerns support to the entrepreneur in providing liquidity and support to day-to-day activities due to the financial difficulties that have occurred to the entrepreneur as a result of the COVID-19 outbreak. Financial assistance under scheme SA.57015 (2020/N)
Research on data transmission efficiency of JSON

To give more effective reference for choosing data transmission format in web development,the data transmission efficiency of JSON(JavaScript object notation) which is the mainstream of current data transmission format is studied.First,the calculation formulas of XML and FSV is analyzed and researched,then the JSON data record is analyzed and the calculation formula of JSON about the data transmission overhead is presented innovatively.Compared the data transmission overhead,time and the deserializatal efficiency of JSON,XML and FSV(fixed-sized file) quantitatively,experimental data show that the data transmission efficiency of JSON is higher than other data transmission formats,this provide a optimizatal reference program for choosing data transmission format in light-weight applications.
HIGH-PERFORMANCE TYRE FOR VEHICLE WHEELS

Tyre (100) for vehicle wheels, comprising: - a carcass structure (101) shaped in a substantially toroidal configuration, the opposite lateral edges of which are associated with respective right-hand and left-hand bead wires (102) to form respective beads; - a belt structure (106) applied in a radially external position with respect to said carcass structure; - a tread band (109) radially superimposed on said belt structure; - at least one layer of crosslinked elastomeric material (111) applied in a radially internal position with respect to said tread band; - a pair of sidewalls (108) applied laterally on opposite sides with respect to said carcass structure; wherein said at least one layer of crosslinked elastomeric material has the following characteristics: - a dynamic elastic modulus (E'), measured at 70°C, not lower than 20 MPa, preferably of from 25 MPa to 50 MPa; - a ratio between tensile modulus at 100% elongation (M100) and tensile modulus at 10% elongation (M10) not lower than 1.5, preferably of from 2 to 5. Preferably said at least one layer of crosslinked elastomeric material is placed between said tread band and said belt structure.
Intelligent fish feeding through integration of enabling technologies  and circular principle

iFishIENCi will deliver breakthrough innovations supporting sustainable aquaculture, based on enabling technologies and circular principles, thereby providing the European aquaculture industry with the competitive advantage and growth stimulation needed to be a mover in revolutionizing global efficiency in fish production and meet society's needs for food from the ocean. This ambitious task will be achieved by providing to the market the  iFishIENCi Biology Online Steering System (iBOSS) that significantly improves production control and management for all fish aquaculture systems.  iBOSS will maximise feed utilisation through smart feeding, provide continuous monitoring of fish behaviour, health and welfare and reduce response times to aberrations.  iFishIENCi will target circular principles and zero waste by qualifying new and sustainable organic value chains for feeds, and valorisation of by-products. iFishIENCi´s innovations will provide important new assets to  the consortiums SMEs, fish-farmers, feed producers and technology providers in the aquaculture sector, leading to market growth and job creation. Assets will be maximized through a comprehensive sustainability assessment and engagements with the sector, regulators and consumers. 11 European companies (SMEs and larger companies) and 7 research & Innovation expert groups are joining effort to achieve this innovation leap towards the implementation of smart feeding and smart breeding into the fish farming industry.
Glaucocalyxin A Inhibits Platelet Activation and Thrombus Formation Preferentially via GPVI Signaling Pathway

Platelets play a pivotal role in atherothrombosis and the antiplatelet agents have been proved to be useful in preventing onset of acute clinical events including myocardial infarction and stroke. Increasing number of natural compounds has been identified to be potential antiplatelet agents. Here we report the antiplatelet effect of glaucocalyxin A (GLA), an ent-diterpenoid that we isolated and purified from the aerial parts of Rabdosia japonica (Burm. f.) var. glaucocalyx (Maxim.) Hara, and investigate the molecular mechanisms by which GLA inhibits platelet activation and thrombus formation. The effect of GLA on platelet activation was measured using platelets freshly isolated from peripheral blood of healthy donors. Results showed that pretreatment of human platelets with lower concentrations of GLA (0.01 μg/ml, 0.1 μg/ml) significantly inhibited platelet aggregation induced by collagen (P<0.001) and CRP (P<0.01), a synthetic GPVI ligand, but not by ADP and U46619. Accordingly, GLA inhibited collagen-stimulated tyrosine phosphorylation of Syk, LAT, and phospholipase Cγ2, the signaling events in collagen receptor GPⅥ pathway. GLA also inhibited platelet p-selectin secretion and integrin activation by convulxin, a GPVI selective ligand. Additionally, GLA was found to inhibit low-dose thrombin-induced platelet activation. Using a flow chamber device, GLA was found to attenuate platelet adhesion on collagen surfaces in high shear condition. In vivo studies showed that GLA administration increased the time for complete occlusion upon vascular injury in mice, but did not extend tail-bleeding time when mice were administered with relatively lower doses of GLA. Therefore, the present results provide the molecular basis for the inhibition effect of GLA on platelet activation and its in vivo effect on thrombus formation, suggesting that GLA could potentially be developed as an antiplatelet and antithrombotic agent.
Membrane organic fouling and the effect of pre-ozonation in microfiltration of secondary effluent organic matter

Factors associated with membrane organic fouling during secondary effluent organic matter (EfOM) microfiltration were explored. Ozone application and its effects on EfOM characteristics along with pre-ozonation effects on EfOM membrane fouling were also studied. Microfiltration tests with EfOM and its hydrophilic and hydrophobic fractions show that hydrophilic substances (HIS) have a stronger fouling potential. This is explained through analysis that reveals HIS possessing a higher macromolecular and carboxylic group content along with higher soluble microbial products (SMP) or SMP-like substances. Adhesion forces directly measured with atomic force spectroscopy (AFM) proved that HIS had the highest affinity to pristine and EfOM fouled membrane. Pre-ozonation effects include an increase in carboxylic and phenolic groups which may aggravate membrane fouling. However, the reduction of dissolved organic carbon (DOC) (including mineralization of small organic molecules) and breaking of large molecules are the dominant criteria for fouling reduction.
COMBINED SURFACE AND DOWNHOLE KICK/LOSS DETECTION

A method for verifying that a kick or loss detected by surface monitoring equipment has occurred includes: receiving an input signal having notification that a kick or a loss has been detected in an earthen borehole during a time interval when drilling fluid is not being pumped into a drill string disposed in the borehole; sensing a pressure in the borehole to provide sensed pressure readings; comparing the sensed pressure readings to an upper threshold and a lower threshold; verifying that a kick has occurred if the notification comprises a kick detection and the sensed pressure reading are above the upper threshold; verifying that a loss has occurred if the notification comprises a loss detection and the sensed pressure readings are below the lower threshold; and transmitting a kick or loss verification signal to a signal receiving device upon verification that the kick or loss has occurred.
The National Birth Defects Prevention Study: How to communicate data

The National Birth Defects Prevention Study is a population-based case-control study. The study has actively sought to identify children with any of 34 specified types of malformation. The mothers of affected and unaffected children have been interviewed with regard to demographic information, lifestyle factors, and exposures. A large number of published studies have appeared and continue to appear on diverse exposures and outcomes. An example of such a study identified an increased odds ratio for ondansetron use among the mothers of children with cleft palate. Possible explanations for associations between exposures and outcomes are chance, error, and causation. The ondansetron-cleft palate association may have arisen by chance given the large number of comparisons made in the study. Error appears unlikely as an explanation of the association. The assessment of causation in teratology uses a systematic evaluation based on the Hill criteria or similar criteria of Shepard or Brent.
Promoting the ecological network in the European Green Belt

During the last century and over decades Central Europe was divided by an insuperable border called the Iron Curtain. Especially the eastern side of the former border was extremely sparsely populated and the border zone itself was left completely unsettled. Since the fall of the Iron Curtain in the late 1980s and the reunion of Eastern and Western Europe this former border area now runs like a Green Belt of valuable landscapes and ecosystems throughout Europe, comprising of protected and non-protected areas, covering  over more than 12500 km and bordering seven Central Europe Member States. Therefore this Green Belt area offers the opportunity to create and conserve not only a unique ecological refuge but also to develop these peripheral rural areas in the heart of Europe in a sustainable and integrated way.

Greennet will contribute to this goal, not only by the protection of endangered species in certain areas but mainly by the promotion of an interconnected and barrier free ecological corridor, especially in the areas of outmost ecological importance (National Parks etc.). The project  aims however not to neglect the large intermediate areas which don’t have any particular protection status as these areas of non- or low protection status also need to be included in the network ensuring their important function as stepping stones between valuable habitats. The project has envisioned not only to connect nature but also to bring people together by connecting cultural heritage with natural one at the same time.
Overview of the MOSAiC expedition: Snow and sea ice

Year-round observations of the physical snow and ice properties and processes that govern the ice pack evolution and its interaction with the atmosphere and the ocean were conducted during the Multidisciplinary drifting Observatory for the Study of Arctic Climate (MOSAiC) expedition of the research vessel Polarstern in the Arctic Ocean from October 2019 to September 2020. This work was embedded into the interdisciplinary design of the 5 MOSAiC teams, studying the atmosphere, the sea ice, the ocean, the ecosystem, and biogeochemical processes. The overall aim of the snow and sea ice observations during MOSAiC was to characterize the physical properties of the snow and ice cover comprehensively in the central Arctic over an entire annual cycle. This objective was achieved by detailed observations of physical properties and of energy and mass balance of snow and ice. By studying snow and sea ice dynamics over nested spatial scales from centimeters to tens of kilometers, the variability across scales can be considered. On-ice observations of in situ and remote sensing properties of the different surface types over all seasons will help to improve numerical process and climate models and to establish and validate novel satellite remote sensing methods; the linkages to accompanying airborne measurements, satellite observations, and results of numerical models are discussed. We found large spatial variabilities of snow metamorphism and thermal regimes impacting sea ice growth. We conclude that the highly variable snow cover needs to be considered in more detail (in observations, remote sensing, and models) to better understand snow-related feedback processes. The ice pack revealed rapid transformations and motions along the drift in all seasons. The number of coupled ice–ocean interface processes observed in detail are expected to guide upcoming research with respect to the changing Arctic sea ice.
The GDP Illusion: Value Added versus Value Capture

The ’GDP Illusion” is a fault in perception caused by defects in the construction and interpretation of standard economic data. Its main symptom is a systematic underestimation of the real contribution of low-wage workers in the global South to global wealth, and a corresponding exaggerated measure of the domestic product of the United States and other imperialist countries. These defects and distorted perceptions spring from the neoclassical concepts of price, value, and value added which inform how GDP, trade, and productivity statistics are devised and comprehended. The result is that supposedly objective and untarnished raw data on GDP, productivity, and trade are anything but; and standard interpretations conceal at least as much as they reveal about the sources of value and profit in the global economy.This article can also be found at the Monthly Review website, where most recent articles are published in full.Click here to purchase a PDF version of this article at the Monthly Review website.
Strongly correlated physics and materials for energy technology

Materials where conduction electrons experience strong correlation in their dynamics, are both a challenge to the current quantum theories of matter and a mine for possible technological applications. High-temperature copper- and iron-based superconductors and heavy-fermions with large thermoelectric responses are examples of materials with high potential impact on energy transmission and storage technologies or high-magnetic field applications. 

Recently, the discovery that the well known atomic ""Hund's rules"" have a surprisingly great and diversified influence on the conduction electrons in d-electron materials changed the traditional view of electronic correlation as a competition between kinetic energy and Coulomb repulsion, adding Hund's exchange energy as a third axis. 

This project, by using state-of-the-art computational techniques for correlated materials, aims at clarifying the influence of the new Hund's driven mechanisms as possible enhancers of high-Tc superconductivity and of thermoelectric and thermomagnetic properties.
In particular Hund's coupling can induce the coexistence of weakly and strongly correlated conduction electrons, culminating in orbital-selective Mott insulating states or in heavy-fermionic physics. 
We then aim at the creation of a new class of transition-metal (d-electron) compounds reproducing the properties of the more exotic rare-earth (f-electron) heavy-fermion materials, in a tunable way. Iron-based superconductors exhibit some of these properties and will be used as a starting point for the search and exploration of new and enhanced high-temperature superconductors and thermoelectric/thermomagnetic d-electron materials.  

An exciting application is also proposed, motivating a possible resurgence of technological attention towards thermomagnetic materials: the coating of high-power cables in thermomagnetic materials for self-cooling, and potentially room-temperature superconduction.
Promoting a green agri-food industry through the introduction of aquaponics

Aquaponics is a combined production systems that allows for a reduced environmental impact in the agricultural and food industry. This techniques consists in growing plants without soil and with a reduced water consumption compared to traditional agricultural practices, recycling organic waste from fish farms. Aquaponics has the following benefits: (1) it does not involve the use of fertilizers; (2) it limits the consumption of soil, as plants do not have to fight for nutrients; (3) it does not require pesticides. Hence, aquaponics is considered to be a “green” technology.