SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Integrated, low-cost and stand-alone micro-optical system for grape maturation and vine hydric stress monitoring

This project aims at the development of fully integrated, small, low-cost, standalone smart system used for grape maturation
monitoring. It will consist of an optical detection head ( flexible strip or transparent canopy) connected to the grape bunch,
including power, signal pre-processing, and wireless communications. The detection head will be optically based (UV-VIS-NIR) using
an integration of LED sources and photodiode/interference filter arrays at wafer level or wafer package level. This project aims
at the development of a fully integrated, small, low-cost, standalone device used for grape maturation and vine hydric stress
monitoring. It will consist of an optical detection head connected to the top of the grape bunch, including power, signal
preprocessing, and communications.  Reflectance and fluorescence measurements will be used at various wavelengths to probe spectral signatures for phenols (for instance anthocyanins reflectance have a maximum absorption band at around 500-540nm, and flavonols-reflectance at 300-400 at about 370nm), for clorophile chlorophylls (fluorescence at 680-750nm) and other indexes. pH and Brix will be correlated with the optical reflectance and fluorescence measurements. The project concept originated from conversations between Sogrape (a major wine producing company with estates in Portugal, Spain, Chile and Australia and the realization of the pressing need for the development of a standalone device for grape maturation and vine hydric stress control. Partners with the required know
how were then contacted to bring in and incorporate the various components required at wafer level, wafer package level, component level and system level necessary for the devclopment of an electronic smart system. Furthemore, the consortium as a whole can carry developed systems into volume production.
Allopurinol protects against ischemic insults in a mouse model of cortical microinfarction

Microinfarcts are common in patients with cognitive decline and dementia. Allopurinol (ALLO), a xanthine oxidase (XO) enzyme inhibitor, has been found to reduce proinflammatory molecules and oxidative stress in the vasculature. We here examined the effect of pre-treatment with allopurinol on the cortical microinfarction. C57BL/6J mice were subjected to a permanent single penetrating arteriole occlusion induced by two-photon laser irradiation. Infarction volume, the activation of glial cells and nitrosative stress in the ischemic brain was assessed using immunohistochemistry. Pre-treatment with ALLO achieved 42% reduction of infarct volume and significantly reduced microglia infiltration, astrocyte proliferation and nitrosative stress in the ischemic brain. These data indicate that ALLO protects against microinfarcts possibly through inhibition of nitrosative stress and attenuation of microglia infiltration as well as astrocytes reactivation.
ELECTRONIC SYSTEM DESIGN ANALYSIS SERVICES Present List BEKERJADI CNOOC SES, LTD JAKARTA

At CNOOC SES, Ltd.  as mining companies oil and gas has locations scattered work-in Jakarta and the waters around the Islands A thousand-with the number of workers tetapnyayang reach approximately 850 people where more than 60% workers in offshore, then implementing a computerized system very appropriate.  To that end, in all departments has been equipped with facilities computers to process and process complex data and require a process fast.  Personnel Administration Department under the Human division Resources and Support Service plays an important role in controlling and processing of electronic services present a list of workers, so that the computerized system This addition can improve work efficiency and effectiveness may also increase data accuracy. View of these problems, the author tries to describe and implement in a report that mengambiljudul NOA: ANALYSIS SYSTEM DESIGN SERVICE WORKER present ELEKTRONIKDAFTAR IN CNOOC SES, LTD JAKARTA .
Functionally graded additive manufacturing scaffolds by hybrid manufacturing

Additive Manufacturing (AM) market has grown with trends higher than 20% every year in the last 10 years. Their fast uptake is due to different innovative factors such as no shape limits in manufacturing process, full customisation on the single artefact, localised production and no waste material. In particular the ability to print any shape allows to design the products not following the constricting conventional manufacturing processes but just focalising on their function. This “Design for Function” feature is one of the main drivers for AM uptake on a wider scale production and the limited number of “functional” materials that can be printed or the limit in controlling gradient and surface properties are showing to be an important barrier. This is particularly true in manufacturing of tissue engineering (TE) scaffolds where the technology has a promising growth over the last decade. Scaffolds production for tissue regeneration is one of the main fields where the “Design for Function” feature of AM make the difference relative to the other production techniques if in the production process all the needed “Functions” can be introduced: mechanics, geometry (porosity and shape), biomaterial, bio-active molecules and surface chemical groups.
The FAST project aims to integrate all these “Functions” in the single AM process.
This integration will be obtained by the hybridisation of the 3D polymer printing with melt compounding of nanocomposites with bio-functionalised fillers directly in the printing head and atmospheric plasma technologies during the printing process itself. Final objective of the project is to realize a demonstrator of the proposed hybrid AM technology in order to achieve a small pilot production of scaffolds for bone regeneration with the novel smart features to be tested in some in-vivo trials.
THIN FILM TRANSISTOR ARRAY SUBSTRATE, METHOD FOR FABRICATING THE SAME AND DISPLAY

A TFT array substrate, a method for fabricating the same and a display are disclosed. The TFT array substrate comprises: a plurality of gate lines, a plurality of data lines and a plurality of pixel regions defined by intersecting the plurality of gate lines and the plurality of data lines, a pixel electrode is disposed in each of the pixel regions. The TFT array substrate further comprises: a gate electrode formed on a substrate; a black matrix and an active layer sequentially formed above the gate electrode, the gate electrode and the active layer are isolated from each other via the black matrix overlaying the gate electrode; a source electrode and a drain electrode both formed on the active layer; a color filter layer formed on the source electrode, the drain electrode and the active layer; the pixel electrode is disposed on the color filter layer and connected to the drain electrode by way of a via hole penetrating through the color filter layer.
The Impact of Child-Care Subsidies on Child Development: Evidence from Geographic Variation in the Distance to Social Service Agencies

In recent years, child care subsidies have become an integral part of federal and state efforts to move economically disadvantaged parents from welfare to work. Although previous empirical studies consistently show that these employment-related subsidies raise work levels among this group, little is known about the impact of subsidy receipt on child well-being. In this paper, we identify the causal effect of child care subsidies on child development by exploiting geographic variation in the distance that families must travel from home in order to reach the nearest social service agency that administers the subsidy application process. Using data from the Kindergarten cohort of the Early Childhood Longitudinal Study, our instrumental variables estimates suggest that children receiving subsidized care in the year before kindergarten score lower on tests of cognitive ability and reveal more behavior problems throughout kindergarten. However, these negative effects largely disappear by the time children reach the end of third grade. Our results point to an unintended consequence of a child care subsidy regime that conditions eligibility on parental employment and deemphasizes child care quality.
MALDI-TOF mass spectrometric analysis of α-amanitin, β-amanitin, and phalloidin in urine

A rapid and sensitive method was developed for analysis of α-amanitin, β-amanitin, and phalloidin by matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS). In this method, α-cyano-4-hydroxy cinnamic acid was used as the matrix to assist the ionization of toxins. The identification of α-amanitin, β-amanitin, and phalloidin was achieved through their sodium adducts [M+Na]+ at m/z = 941, 942, and 811, and quantification of the three toxins was also achieved using microcystin RR at m/z = 1038 as internal standard. For all toxins, the limit of detection was 5 ng/ml, and all calibration curves were linear in the range of 10–500 ng/ml using 0.4 ml of urine. The sensitivity for identification was increased about tenfold when the tandem MS (MS–MS) mode was used for detection. Because these quantifications could be achieved in the toxin concentration range of 4–200 ng, the present MALDI-TOF MS method can serve as the most sensitive method so far reported for the analysis of these mushroom toxins. To our knowledge, this study is the first trial to analyze amanitins and phalloidin by MALDI-TOF MS (-MS).
Structure-Function analysis of the calcium channel trpv5

Ion channels are proteins composed of a hydrophillic pore that facilitate ion flow across a plasma membrane. This ionic permeability is controlled by a set of essential properties affecting the channel activation and inactivation in response to voltage, ligands, or intracellular second messengers. The focus of the present project proposal, the transient receptor potential vanilloid channel (TRPV5), forms a specific category within the large TRP familiy of ion channels as it comprises a unique high selectivity for calcium ions together with a calcium-dependent inactivation mechanism that is incompletely understood. Detailed analysis of the TRPV5 channel will provide new structural insights into channel gating that can be extrapolated to other TRP channels, as the current knowledge on the TRP protein structure and its impact on the regulation of the channel function is still limited. 
The key objective of my project is to deliver the first detailed mechanistic view of TRPV5 by connecting Prof. Cheng’s expertise in structural biology with my biophysical background on TRP channel functioning. The following work packages will be addressed:
1) Channel activation mechanism of TRPV5
Elucidation of the 3D structure of integral TRPV5 by single-particle cryo-EM will provide critical structural and mechanistic insight into calcium-dependent regulation of channel function.
2) Intramolecular regulation of TRPV5
Reconstitution of TRPV5 into lipid nanodiscs and liposomes allows detailed study on lipid regulation and the mechanism of channel inactivation
Taken together, this project focuses on the structure-function analysis of TRPV5, a distinctive calcium-selective TRP channel. The goal is to elucidate the structure of the TRPV5 channel, and to unravel functional domains that are involved in channel function at the mechanistic level. This will ultimately advance our understanding of the molecular differences of activation, ion permeation and gating of TRP channels.
Assignment of Different-Sized Inputs in MapReduce.

A MapReduce algorithm can be described by a mapping schema, which assigns inputs to a set of reducers, such that for each required output there exists a reducer that receives all the inputs that participate in the computation of this output. Reducers have a capacity, which limits the sets of inputs that they can be assigned. However, individual inputs may vary in terms of size. We consider, for the first time, mapping schemas where input sizes are part of the considerations and restrictions. One of the significant parameters to optimize in any MapReduce job is communication cost between the map and reduce phases. The communication cost can be optimized by minimizing the number of copies of inputs sent to the reducers. The communication cost is closely related to the number of reducers of constrained capacity that are used to accommodate appropriately the inputs, so that the requirement of how the inputs must meet in a reducer is satisfied. In this work, we consider a family of problems where it is required that each input meets with each other input in at least one reducer. We also consider a slightly different family of problems in which, each input of a set, X, is required to meet each input of another set, Y , in at least one reducer. We prove that finding an optimal mapping schema for these families of problem is NP-hard, and
HERMETIC SEALING AND ADJUSTABLE VALVE CONTROL, FLOW REGULATING, SELF VENTING, CLOSURE APPARATUS

An improved closure apparatus comprising generally of cylindrical members and varied pourable cylindrical spout apparatuses The apparatus comprises an inner sealer ring assembly with a permanent tamper evident seal which mates directly on the neck of a container, the apparatus further comprises an optional spout, funnel, top stopper plug or a multitude of novelty apparatus mechanisms The closure has, but not limited to having a two-piece configuration The pieces of the closure are affixed together to form a one-piece solid construction in its basic form The inner sealer ring assembly hermetically seals and reseals containers during primary use During primary use, the apparatus remains is attached to its mated container so there is reduced throw away and containment of residual liquids and other viscous and pourable materials, condiments and dry goods, preventing splashing and spillage The apparatus further comprises a valve control which performs as an adjustable flow control mechanism that enables atmosphere in, as product is dispensed, reducing gurgling, burping and spitting.
Crystallo-co-agglomeration: A novel particle engineering technique

Crystallo-co-agglomeration (CCA) is a novel particle engineering/design technique developed by Kadam et al, to overcome the limitations of spherical crystallization (SC). Basically, it’s single step process used for size enlargement of single, two or more, small dose or large dose drugs, in combination with or without diluent. The process of CCA involves simultaneous crystallization and agglomeration of drug/s with/without excipients/s from good solvent and/or bridging liquid by addition of a non-solvent.Till date CCA has been applied for spherical agglomeration of talc, bromhexine hydrochloride–talc, ibuprofen–talc, ibuprofen–paracetamol, and naproxen–starch. The spherical agglomerates obtained by CCA can be used as intact beads (encapsulated spansules) or directly compressible tablet intermediates having satisfactory micromeritic (flowability), mechanical (friability, crushing), compressional (compressibility, compactibility), and drug release properties. Modified drug release from agglomerates and compacts thereof can be achieved using suitable polymer composition in the process design. Thus, it can be concluded that, CCA is a simple and cost effective process, which can be tailor-made for particle design of all majority of drugs and combinations thereof.
Computational propaganda: investigating the impact of algorithms and bots on political discourse in europe

Social media can have an impressive impact on civic engagement and political discourse. Yet increasingly we find political actors using digital media and automated scripts for social control. Computational propaganda—through bots, botnets, and algorithms—has become one of the most concerning impacts of technology innovation. Unfortunately, bot identification and impact analysis are among the most difficult research challenges facing the social and computer sciences.

COMPROP objectives are to advance a) rigorous social and computer science on bot use, b) critical theory on digital manipulation and political outcomes, c) our understanding of how social media propaganda impacts social movement organization and vitality. This project will innovate through i) “real-time” social and information science actively disseminated to journalists, researchers, policy experts and the interested public, ii) the first detailed data set of political bot activity, iii) deepened expertise through cultivation of a regional expert network able to detect bots and their impact in Europe.

COMPROP will achieve this through multi-method and reflexive work packages: 1) international qualitative fieldwork with teams of bot makers and computer scientists working to detect bots; 2a) construction of an original event data set of incidents of political bot use and 2b) treatment of the data set with fuzzy set and traditional statistics; 3) computational theory for detecting political bots and 4) a sustained dissemination strategy. This project will employ state-of-the-art “network ethnography” techniques, use the latest fuzzy set / qualitative comparative statistics, and advance computational theory on bot detection via cutting-edge algorithmic work enhanced by new crowd-sourcing techniques.

Political bots are already being deployed over social networks in Europe. COMPROP will put the best methods in social and computer science to work on the size of the problem and the possible solutions.
Genetically Modified Murine Adipose-Derived Mesenchymal Stem Cells Producing Interleukin-2 Favor B16F10 Melanoma Cell Proliferation

Adipose-derived mesenchymal stem cells (ADSCs) are attractive tools for cancer gene therapy due to their intrinsic tropism to the tumor environment. Interleukin-2 (IL2) is recognized as a key regulatory molecule, which enhances the activity and growth of the immune effector cell function. High-Dose IL2 Therapy is an option for treatment of malignant melanoma but has frequent, often serious and sometimes life-threatening side effects. Here we investigated the effect of genetically modified ADSCs (GM-ADSCs) expressing IL2 in immunocompetent mouse models of subcutaneous and lung metastatic melanoma. Prior to in vivo studies, we demonstrated that IL2 produced by GM-ADSCs may act as a growth factor for melanoma cells due to the increased viability and reduced apoptosis of melanoma cells after in vitro treatment. Subcutaneous co-injection of IL2-expressing ADSCs with melanoma cells significantly enhanced the melanoma tumor growth. Furthermore, histological analysis of subcutaneous tumors for IL2 and Melan-A (a melanocytic differentiation marker) confirmed that most of cells in melanoma/IL2-ADSC co-injected tumors are melanoma cells, not IL2-ADSCs. In pulmonary metastases model, melanoma cells were injected intravenously and 10 days later mice were treated by systematical injection of GM-ADSCs. Intravenously injected IL2-ADSCs engrafted into melanoma lung tumors but were unable to reduce melanoma lung metastases. Besides, administered IL2-ADSCs significantly reduced systemic CD4+ cells and did not impact the total survival of lung metastases melanoma bearing mice. In conclusion, this study showed that IL2-producing ADSCs can favor B16F10 melanoma cell proliferation. Therefore, therapies utilizing IL2 have to be taken into careful consideration.
Using a neonatal immunostimulant to reduce mortality and increase productivity in poultry farms

VitamFero, an innovative French SME, is aiming to develop a new approach to protect chickens against infectious diseases during their first weeks of life. The PROVICOL project aims to induce a strong innate immune response in young chickens in order to protect them against a large panel of infectious diseases. 

1 - PROVICOL will substantially reduce mortality and morbidity rates in chicken breeding thereby improving the overall breeding production process. 
2 - This will also lead to a substantial decrease in the use of antibiotics in breeding establishments.
During the feasibility part (6 months) of PROVICOL, VitamFero will focus the study on technical matters (validation and optimisation of induced innate immune response) and on a business approach. The objective is to confirm, on the basis of previous encouraging results, the wider market opportunity for this product by conducting an economic feasibility study and elaborating a business plan in order to prepare for its marketing. This feasibility study will also validate the market strategy deployment and will improve the business impact of the project (pharmaco-economic study over 3 countries).

The PROVICOL project will generate an expected turnover of 426 million € (127millions € for VitamFero) within 10 years. Provicol is a key project for VitamFero and will act as a lever for the growth of the company, especially for an international commercial deployment.
ATP-mediated vasodilatation occurs via activation of inwardly rectifying potassium channels in humans

Circulating ATP possesses unique vasomotor properties in humans and has been hypothesized to play a role in vascular control under a variety of physiological conditions. However, the primary downstream signalling mechanisms underlying ATP-mediated vasodilatation remain unclear. The purpose of the present experiment was to determine whether ATP-mediated vasodilatation is independent of nitric oxide (NO) and prostaglandin (PG) synthesis and occurs primarily via the activation of Na(+)/K(+)-ATPase and inwardly rectifying potassium (K(IR)) channels in humans. In all protocols, young healthy adults were studied and forearm vascular conductance (FVC) was calculated from forearm blood flow (measured via venous occlusion plethysmography) and intra-arterial blood pressure to quantify local vasodilatation. Vasodilator responses (%FVC) during intra-arterial ATP infusions were unchanged following combined inhibition of NO and PGs (n = 8; P > 0.05) whereas the responses to KCl were greater (P < 0.05). Combined infusion of ouabain (to inhibit Na(+)/K(+)-ATPase) and barium chloride (BaCl(2); to inhibit K(IR) channels) abolished KCl-mediated vasodilatation (n = 6; %FVC = 134 ± 13 vs. 4 ± 5%; P < 0.05), demonstrating effective blockade of direct vascular hyperpolarization. The vasodilator responses to three different doses of ATP were inhibited on average 56 ± 5% (n = 16) following combined ouabain plus BaCl(2) infusion. In follow-up studies, BaCl(2) alone inhibited the vasodilator responses to ATP on average 51 ± 3% (n = 6), which was not different than that observed for combined ouabain plus BaCl(2) administration. Our novel results indicate that the primary mechanism of ATP-mediated vasodilatation is vascular hyperpolarization via activation of K(IR) channels. These observations translate in vitro findings to humans in vivo and may help explain the unique vasomotor properties of intravascular ATP in the human circulation.