SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Crowned dithiocarbamate metal complexes and methods for their use

Compositions containing crowned dithiocarbamate metal complexes and methods of using these compositions; neutral and cationic radioactive metal-nitrido complexes of crowned dithiocarbamates (DTCs) and methods of using these complexes as radiopharmaceuticals for diagnosis and treatment of cardiovascular disorders, infectious diseases, and cancer; tripodal chelatormetal complexes of crowned DTCs and methods of using these complexes for treating diseases such as those characterized by nitric oxide overproduction; and methods of using crowned DTCs for heavy metal detoxification are described.
Building smart governance to manage flooding risk of river communities

SMARTRIVER, involving 6 river basins affected by climate change  (Misa, Glafkos and Charadros, Neretva, Drava, Vjosa, Bosna), is based on three high territorial challenges:

- Increasing the climate adaptation capacity of river communities.

- Creating a smarter model of governance, by enhancing PPs’ capabilities to transnationally tackle climate-change in river basins.

- Promoting active participation of local communities in planning risk reduction strategies.

Indeed, SMARTRIVER aims at mainstreaming risk reduction policies on river basins of Adriatic-Ionian areas, improving the adaptation capabilities of PPs, stakeholders and relevant actors, providing a common framework to face with environmental, economic and social vulnerability to climate change.

The project, based on a participative approach carried on through the Local LABs and the transnational Adriatic Ionian SMARTRIVER network, run 30 months and promotes the development of 6 Flooding Risk Reduction Plans (FRRP) within the River Contracts’ common framework, setting up shared methodologies, structured knowledge exchange and capacity building actions, promoting a transnational model of governance to reduce climate change impact in the Adriatic-Ionian Macro-region. Tailored Pilot actions based on flooding risk assessment are carried on in order to taste the effectiveness of FRRP.

Furthermore, a SMARTRIVER DGT Platform is set up in order to support future synergies and exchange among PPs and relevant stakeholders, providing them with an interactive tool able to horizontally and vertically link river communities at Adriatic-Ionian level. Join interventions will be promoted through the drafting of an Adriatic Ionian Common Strategy for Resilience: the document proposes the adoption of a territorial-coherent approach to tackle flooding risks and climate change impacts, increasing the resilience capacity of the whole territories involved.
Industrial academic initial training network towards specific diagnosis and treatment of age-related gait and balance deficits

Balance and gait deficits are ubiquitous among the older population, and lead to enormous personal, occupational and health care burden. Emerging pharmacological and non-pharmacological interventions to date have only small to moderate effects on these deficits. This is likely due to remaining fundamental questions on underlying mechanisms and treatment. The present project Keep Control consists of a rare EU-wide combination of experts from clinical, biomechanic and neuroscience research, along with experts from the industry, who all aim at gaining a better understanding and treatment of balance and gait deficits in older adults. We aim to scrutinize aspects such as: (1) comparability of balance and gait assessment in the clinic and the home environment, (2) gait and balance deficits as prodromal markers of neurodegeneration, and as markers to differentiate between Parkinsonian syndromes, (3) association between freezing of gait and balance, and (iv) gait and balance deficits in patients with sarcopenia. Tools such as sophisticated lab-based gait and balance assessment devices, perturbation treadmill, wearable devices, electrophysiology and blood and tissue investigations will be implemented. We will further employ promising therapeutic strategies for specific gait and balance deficits in older adults, including both pharmacologic and non-pharmacologic strategies. An entire work package will be dedicated to a novel harmonization and integration approach across the whole network: It will (i) harmonize assessment protocols based on the WHO definition of health and disability, to pave the way for an exhaustive meta-analysis of all data collected, and (ii) foster the active involvement of all study participants by implementation of a participant-controlled medical record. In summary, Keep control will cover the entire range of expertise necessary and utilize cutting edge technology to educate fellows in the area of gait and balance deficits in older adults.
Novel business on durable and compostable products based on recycled plastic

More than 25 million tonnes of plastic waste are produced every year in the EU28 (50 kg per EU citizen). Although the rates of plastic waste recovery have increased (26% mechanical recycling; 35.6% energy recovery), 38.4% of this waste is still landfilled (9.6 million tonnes). This goes against the EU Waste Framework Directive 2008/98/EC as it has a high environmental impact (0.105kg CO2/kg plastic waste landfilled; production of one million tonnes of CO2) and wastage of resources (€590/tonne of recycled plastic ; losses of €5,664 M).

INTERVAL, S.A. is a family-owned business created in 1982 specialised the recycling and transformation of plastics. We employ 22 people and have an annual turnover of €3,240,066. We produce more than 7,000 tonnes of plastic products per year using the most advanced technology in our production processes.Through ReDurComp, we aim to launch innovative, low-cost products onto the EU market based on premium recycled PE. We will start by introducing two products for which a clear market need has been identified (i.e. plastic sacks for household waste collection and plastic covers for pallets). As a whole, sales of about €48.3 million are forecast within a five-year period, generating profits of over €4.8 million.
 
During phase 1, a feasibility study including a business plan will be developed  in line with the overall internationalisaton and growth plan of our company. This study will include: (1) a market assessment to confirm INTERVAL’s products acceptance in the two segments considered; (2) a technical assessment to validate our recycled PE material according to relevant EU standards and procedures, as well as final testing; (3) a stakeholder assessment to identify the key players and activities for the second and third phases of the project; (4) a complete Business Plan including a cost analysis of raw materials and production activities, marketing and sales strategies, target market, investment requirements, and sales partners.
A simple reaction-diffusion model for initial stages of biofouling in reverse osmosis membranes

Biofouling is a critical issue in membrane water and wastewater treatment as it greatly compromises the efficiency of the treatment processes and consequently increases operational and maintenance costs. It is difficult to control this operational challenge, so the development of effective biofouling monitoring and control methods and strategies is a critical issue for membrane technology and applications. In this work, we develop a simulation approach for evaluating the operational time of reverse osmosis (RO) membranes based on a reaction-diffusion (RD) type of model. This approach would help to understand different factors involved in the formation of biofilms including microbial population dynamics (replication and death rates of microbial cells) and nutrient consumption. The model is focused on the initial stages of the membrane biofouling that is initiated by attachment of microbial species to the membrane leading to pore blocking followed by the formation of thick cake layer. We applied this approach to study the RO membrane biofouling by Picochlorum algae, the most common biofouling agent in the seawater of the Arabian Gulf, at known contents of total organic carbon and essential nutrients. We found that the biofilm growth dynamics on an RO membrane is mainly defined by the ratio of the replication and death rates of microbial cells. The proposed approach should be useful for fast evaluation of the RO membrane performance in different environmental conditions without using significant computational resources. This methodology allows generalization for multi-microbial and multi-nutrient systems. The establishment of effective fouling control strategies should decrease operational and maintenance costs of RO membrane systems.
Phase-Only Antenna Array Reconfigurability with Gaussian-Shaped Nulls for 5G Applications

This paper presents a fast iterative method for the synthesis of linear and planar antenna arrays of arbitrary geometry that provides pattern reconfigurability for 5G applications. The method enables to generate wide null regions shaped according to a Gaussian distribution, which complies with recent measurements on millimeter-wave (mmWave) angular dispersion. A phase-only control approach is adopted by moving from the pattern provided by a uniformly excited array and iteratively modifying the sole phases of the excitations. This allows the simplification of the array feeding network, hence reducing the cost of realization of 5G base stations and mobile terminals. The proposed algorithm, which is based on the method of successive projections, relies on closed-form expressions for both the projectors and the null positions, thus allowing a fast computation of the excitation phases at each iteration. The effectiveness of the proposed solution is checked through numerical examples compliant with 5G mmWave scenarios and involving linear and concentric ring arrays.
Structure and Dynamics of a Tropical Dry Forest Plant Community

This thesis is spurred by the overarching question “why is a plant where it is in space and time?”, which, when asked in different global communities over the last century or so, has contributed to the development of general theories of plant community ecology and has provided information relevant to understanding, managing, and predicting the future of those communities. The question is asked in the context of a seasonally dry tropical forest (SDTF) plant community in southern India, based on long-term research conducted in a permanent 50-ha sampling plot. We employ a layered approach to answering this question, wherein we deconstruct the structure and dynamics of the plant community by first establishing the spatial structure of soils, topography and lithology in the plot. Next we assess how this spatial structure, together with temporal variation in precipitation, affects plant abundances in space and time. Next we break up abundance variation into the components of recruitment, mortality and stem radial growth and assess how these respond to variation in environmental factors such as precipitation, temperature, soils, topography and fire, and biotic neighborhoods.

In Chapter 2, we examine the roles of lithology, topography, vegetation and fire in generating local-scale (<1 km2) soil spatial variability in the 50-ha plot. For this, we mapped soil (available nutrients, Al, total C, pH, moisture and texture in the top 10cm), rock outcrops, topography, all native woody plants ≥1 cm diameter at breast height (DBH), and spatial variation in fire frequency (times burnt during the 17 years preceding soil sampling) in a permanent 50-ha plot. Unlike classic catenas, lower elevation soils had lesser moisture, plant-available Ca, Cu, Mn, Mg, Zn, B, clay and total C. The distribution of plant-available Ca, Cu, Mn and Mg appeared to largely be determined by the whole-rock chemical composition differences between amphibolites and hornblende-biotite gneisses. Amphibolites were associated with summit positions, while gneisses dominated lower elevations, an observation that concurs with other studies in the region which suggest that hillslope-scale topography has been shaped by differential weathering of lithologies. This “inverse catena” pattern is possibly reinforced by topography due to nutrient leaching and clay depletion in the drainage area. Neither NO3 – N nor NH4+-N was explained by the basal area of trees belonging to Fabaceae, a family associated with N-fixing species, and no long-term effects of fire on soil parameters were detected. A strong SW-NE trending P pattern remained unexplained by any of the factors considered. Local-scale lithological variation is an important first-order control over soil variability at the hillslope scale in this SDTF, by both direct influence on nutrient stocks and indirect influence via control of local relief.

 
The extent to which interspecific niche differences structure plant communities is highly debated, with extreme viewpoints ranging from fine-scaled niche partitioning,…
Distilling the Antecedents and Enabling Dynamics of Leader Moral Courage: A Framework to Guide Action

Intelligent, robust and courageous nursing leadership is essential in all areas of nursing, including mental health. However, in the nursing leadership literature, the theoretical discourse regarding how leaders recognise the need for action and make the choice to act with moral purpose is currently limited. Little has been written about the cognitions, capabilities and contextual factors that enable leader courage. In particular, the interplay between leader values and actions that are characterised as good or moral remains underexplored in the nursing leadership literature. In this article, through a discursive literature synthesis we seek to distill a more detailed understanding of leader moral courage; specifically, what factors contribute to leaders' ability to act with moral courage, what factors impede such action, and what factors do leaders need to foster within themselves and others to enable action that is driven by moral courage. From the analysis, we distilled a multi-level framework that identifies a range of individual characteristics and capabilities, and enabling contextual factors that underpin leader moral courage. The framework suggests leader moral courage is more complex than often posited in theories of leadership, as it comprises elements that shape moral thought and conduct. Given the complexity and challenges of nursing work, the framework for moral action derived from our analysis provides insight and suggestions for strengthening individual and group capacity to assist nurse leaders and mental health nurses to act with integrity and courage.
Quantitative tomography using  coupled physics of waves

Tomographic images are a valuable tool in various applications of medicine and biomedicine, industry and in security applications. Although efficient tomographic imaging techniques exist, development of new modalities that would overcome the limitations of the existing techniques are required. Overall, there is a need for development of new tomographic techniques that would provide quantitative information of unknown parameters of interest, such as tomographic images on the concentration of molecules. In particular, information on the reliability of the tomographic images is required.
 
The objective of the project is to develop quantitative tomographic imaging technique based on coupled physics of waves. In coupled physics imaging, contrast and resolution originating from different physical phenomena are combined. In the project, light, microwaves and ultrasound, i.e. waves, will be utilised through photoacoustic, thermoacoustic and acousto-optic effects. These techniques will be developed to produce tomographic images with an outstanding quantitative contrast in the sense of statistical information and modelling of uncertainties, combined with superior resolution and imaging depth. 

Most tomographic imaging techniques are ill-posed problems that need to be approached in the framework of inverse problems. In the project, a Bayesian approach to ill-posed inverse problems, which supports the quantitative nature of the problem, will be taken. In the project, mathematical modelling and computational methods will be developed in close connection with experimental system development. The research is founded on a strong understanding of the underlying physics of coupled physics problems, knowledge on instrumentation on the related fields and experimental tomography, and state-of-the-art methods of computational inverse mathematics, that all come together in the PI’s research group.
A cell separation microfabricated platform for cell migration and invasion assays

Cell migration is essential for tissue development, homeostasis, tumor progression, including the responses to wounds and inflammation. Cell interactions with their microenvironment affect many cellular functions such as spreading, migration and even differentiation. These interactions can be studied by incorporating micro- and nanotechnology-related tools. The design of substrates based on these technologies offers new possibilities to probe the cellular responses to changes in their physical environment. The investigations of the physical interactions of cells and their surrounding matrix can be carried out in well-defined and near physiological conditions. In tissues, cells encounter confined environments and narrow spaces that could favor or prevent migration. In the DURACELL ERC project, we are studying the impact of substrate stiffness on cell migration. We propose to develop and use microfabricated substrates to control substrate confinement and topography and thus analyze cellular responses. Such elastomeric substrates are designed that contain ordered micron-sized pillars allowing cells to transmigrate through versatile confined spaces. The development of accurate methods to study cellular transmigration is important to answer fundamental biological processes and for cell-based therapy and drug screening. The well-accepted methods for transmigration assays including Boyden chambers, microfluidic devices present important limitations including spatial and temporal resolutions, limited variability and control of porosity composition and geometry. To overcome these limitations, the goal of TRANSCELL is to develop in-plane micropillar substrates whose geometry can be easily tuned to control and analyze cell transmigration, cell sorting and ultimately genetic expression profiles. We anticipate that the versatility of this method will offer new opportunities for fundamental research in cell biology, but also in cell therapies and drug screening.
Schutz des geistigen Eigentums für ParcelSea-Produkt

Antrag auf Schutz des geistigen Eigentums für das Produkt ParcelSea und Durchführung einer Studie über die Handlungsfreiheit
Compression of genomic data to facilitate precision medicine

Healthcare is a worldwide challenge. To fight diseases, medicated treatments are common. However, statistics show that 3 out of 5
treatments are currently inadequate. Personalised Medicine is one of the fundamental discipline to fix those inefficient treatments.
Based on DNA, genomic sequencing is performed to achieve a personalised diagnostic for the patient. Unfortunately, this type of
medicine encounters some limitations. One of them is the astronomical amount of numerical genomic data that it generates. With
these volumes, transferring, storing, archiving and analysing the data become an issue. To counteract these issues, ENANCIO has
developed an algorithm, called Lena, to compress genomic data and improve the entire genomic data workflow. ENANCIO aims to
provide a solution to improve the transfer and storage of those data, but also to improve speed and precision of data analysis. There
is an urgent need to break down the barriers that exist by giving a genomic data compression solution which considers the entire
genomic data workflow. Currently, no compression solution adresses the entire dataflow. Such a technology is a new challenge.
Thanks to artificial intelligent value smoothing technology, ENANCIO aims to bring the only one technology improving the entire
value chain of the genomic data, from the improvement of the compression rate and compression time, allowing a faster e-transfer
and a lighter storage, to the improvement of the time and precision of analysis. Genomic data market has shown a fast raise and will
reach 2 billion € in 2025. ENANCIO addresses two categories of customers, private and academic sequencing platforms who manage
thousands giga bytes of data. During ORIGAMI project, ENANCIO aims to study the feasibility of the algorithm to fit with the latest
sequencers on the market, NovaSeq platform from Illumina (90% of market share). This new platform will be the standard of
tomorrow, justifying the need of compatibility with LENA algorithm.
Production of sucralose without intermediate isolation of crystalline sucralose-6-ester

There is disclosed a process for producing sucralose from sucralose-6-ester whereby the sucralose-6-ester is deacylated directly either prior to or after removal of the tertiary amide reaction vehicle from the neutralized chlorination reaction mixture, to produce an aqueous solution of sucralose plus salts and impurities, from which sucralose is recovered by extraction and is then preferably purified by crystallization.
Electronic Bonding Revealed by Electron Diffraction

When atoms come together to form a crystal, a redistribution of electron charge creates bonds that govern almost all of the crystal's physical and chemical properties. Ab initio calculations can provide theoretical determination of the bonding charge density, but experimental verification can be fraught with difficulty because the change in the total charge density, as measured via diffraction experiments, is very small. For example, in aluminum (Al), most of the electrons are highly delocalized and form a free electron gas, but some of the electron density forms highly directional bonds. On page 1583 of this issue, Nakashima et al. ( 1 ) demonstrate the use of ultrasensitive convergent-beam electron diffraction (CBED) to map the bonding charge density of Al to an unrivaled accuracy. These results lead to a greater understanding of this metal's mechanical properties.