SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Developing and strengthening cross-sectoral linkages among actors in sustainable biocomposite packaging innovation systems in a Central European circular economy

Paper and cardboard represented 41% of packaging waste generated by weight in the EU-28 in 2013 (about 32.2 million tonnes). The appearance of microplastics in recycled paper secondary materials and compost is becoming a major concern. There is a high potential for mobilizing synergies between business and research in the area of combined paper-bioplastics packaging design, production and recycling in Central Europe. Linkages are not sufficiently established due to lack of awareness among paper packaging producers on new bioplastics materials, a separated focus on plastics and paper in clusters and branch organizations, the lack of a common innovation strategy within a clear European and national legal and economic context and the lack of dedicated tools to support SME’s in introducing new paper-plastics packaging solutions. The main project objective is to provide to stronger linkages between R&D institutions and companies in the area of paper-plastics packaging solutions with the aim to introduce verified biodegradable materials in paper and cardboard packaging. The project foresees an innovative cross-sectoral approach and the involvement of clusters, branch organizations and stakeholders, that will allow to focus on regional economic specialisations and to speed up technology transfer. The Project Partners will establish a Transnational Biocomposite Packaging Centre as a virtual RDI platform that brings together cross-sectoral capacities in paper and bioplastics, linked with regional innovation systems and the European Enterprise Network, supported by an integrated cross-sectoral business support service including a set of dedicated tools tested under pilot actions and disseminated among cluster coordinators and EEN consultants. A Central European Strategy on biocomposite packaging innovation systems shall set the framework, a handbook: "Sustainable Paper-Plastic Design" and an audit tool will help companies to quickly verify opportunities and chose for change.
Approaching the Rate-Distortion Limit With Spatial Coupling, Belief Propagation, and Decimation

We investigate an encoding scheme for lossy compression of a binary symmetric source based on simple spatially coupled low-density generator-matrix codes. The degree of the check nodes is regular and the one of code-bits is Poisson distributed with an average depending on the compression rate. The performance of a low complexity belief propagation guided decimation algorithm is excellent. The algorithmic rate-distortion curve approaches the optimal curve of the ensemble as the width of the coupling window grows. Moreover, as the check degree grows both curves approach the ultimate Shannon rate-distortion limit. The belief propagation guided decimation encoder is based on the posterior measure of a binary symmetric test-channel. This measure can be interpreted as a random Gibbs measure at a temperature directly related to the noise level of the test-channel. We investigate the links between the algorithmic performance of the belief propagation guided decimation encoder and the phase diagram of this Gibbs measure. The phase diagram is investigated thanks to the cavity method of spin glass theory which predicts a number of phase transition thresholds. In particular, the dynamical and condensation phase transition temperatures (equivalently test-channel noise thresholds) are computed. We observe that: 1) the dynamical temperature of the spatially coupled construction saturates toward the condensation temperature and 2) for large degrees the condensation temperature approaches the temperature (i.e., noise level) related to the information theoretic Shannon test-channel noise parameter of rate-distortion theory. This provides heuristic insight into the excellent performance of the belief propagation guided decimation algorithm. This paper contains an introduction to the cavity method.
Delivery of chemo-sensitizing siRNAs to HER2+-breast cancer cells using RNA aptamers

Human epidermal growth factor receptor 2 (HER2) expression in breast cancer is associated with an aggressive phenotype and poor prognosis, making it an appealing therapeutic target. Trastuzumab, an HER2 antibody-based inhibitor, is currently the leading targeted treatment for HER2(+)-breast cancers. Unfortunately, many patients inevitably develop resistance to the therapy, highlighting the need for alternative targeted therapeutic options. In this study, we used a novel, cell-based selection approach for isolating 'cell-type specific', 'cell-internalizing RNA ligands (aptamers)' capable of delivering therapeutic small interfering RNAs (siRNAs) to HER2-expressing breast cancer cells. RNA aptamers with the greatest specificity and internalization potential were covalently linked to siRNAs targeting the anti-apoptotic gene, Bcl-2. We demonstrate that, when applied to cells, the HER2 aptamer-Bcl-2 siRNA conjugates selectively internalize into HER2(+)-cells and silence Bcl-2 gene expression. Importantly, Bcl-2 silencing sensitizes these cells to chemotherapy (cisplatin) suggesting a potential new therapeutic approach for treating breast cancers with HER2(+)-status. In summary, we describe a novel cell-based selection methodology that enables the identification of cell-internalizing RNA aptamers for targeting therapeutic siRNAs to HER2-expressing breast cancer cells. The future refinement of this technology may promote the widespread use of RNA-based reagents for targeted therapeutic applications.
Uncovering the origins of mass: discovery of the di-higgs process and constraints on the higgs self-coupling

The Standard Model of particle physics describes the elementary constituents of matter and their interactions. In 2012, its last ingredient, the Higgs boson, was discovered at the Large Hadron Collider (LHC). The exploration of the Higgs boson is now one of the most exciting avenues to explore for New Physics beyond the Standard Model and allows some of the most pressing problems in theoretical physics to be addressed, such as the origins of the electroweak symmetry breaking mechanism. This important mechanism gives elementary particles their masses but the nature of this mechanism remains a mystery. 

A particularly crucial measurement is the production cross-section of Higgs boson pairs, which provides unique information on the Higgs self-coupling and on the underlying nature of the electroweak symmetry breaking mechanism. Most feasibility studies of the Higgs self-coupling conclude that there will be insufficient data for this measurement in the coming decade. However, my recent feasibility studies indicate that by using the Higgs pair production process with four bottom quarks in the final state, the discovery of the di-Higgs process and its cross section measurement can be made much earlier. This project aims to develop and complete the first measurement of the di-Higgs cross section and most stringent bounds on the Higgs self-coupling before 2023.
To achieve this goal I will develop new experimental techniques to improve the background reduction rates and enhance the signal. The objectives are the development of novel bottom quark energy reconstruction algorithms, new bottom quark and Higgs identification techniques, and neural network analysis tools. Analysis of ATLAS data will then enable searches for New Physics and ultimately the di-Higgs cross section measurement to constrain the Higgs self-coupling. This landmark measurement will lead to the confirmation of how particles acquire mass and open new avenues to understand what lies beyond the Standard Model.
Albania, Montenegro, Italy, Multimodal Transport Connectivity

The project area is fragmented on two sides of the Adriatic-Ionian Sea between Italy, Albania and Montenegro and on two sides of Shkodra/Skadar Lake and Buna/Bojana River between Albania and Montenegro. The area experiences poor accessibility and is characterized by transport systems with low interoperability, thus negatively affecting intra and interregional connectivity. The aim of the project is to establish a long-term active partnership among the relevant stakeholders, via multimodal inland water and maritime transport connections in order to improve connectivity and to facilitate and promote sustainable cross border cooperation in the project area.

The foreseen actions will provide sustainable cross border transport connections (CBTC) over the project area, by optimizing the existing ones, strengthening management and operational skills, ensuring safety and environmental protection measures. The project will contribute in developing international inland water and maritime transport connectivity by applying EU integrated standards in the maritime and inland water sector. For Albania, this is the first intervention in international inland water transport as the country has only limited experience with Fierza-Koman Lake. The main expected outcomes of the project are i) a comprehensive programme of interventions to improve multimodal connectivity in the project area, ii) pilot intervention for multimodal connectivity in the lake and coastal (maritime) area. The beneficiaries of this program will be local Communities and local public authorities of the target area who will benefit from intensified socio-economic interaction, as well as increased skills and management capacities leading in increased ownership over the assets. To guarantee the above, we have committed to exploring all possibilities to secure funding, including through Berlin Process, CB IPA-EU funds, WBIF and other national funding sources.
Study Transition from Water Transport to Basin logistics——Literary Review

Water transportation,especially inland water transportation,cannot satisfy the social demand,which is shown on its poor social recognition and weak infrastructure.With decades' rapid economic development of Chinese basins,many evident changes are happening in water transportation research: from its position discussion to strategy planning,from single to multiplex methods and theories,from micro issues to the top system design,etc.The innovative research is needed and systematic theories should be constructed,however,if the academics want to change fundamentally the current research situation of the so called small,scattered and chaotic.Basin logistics theory is first built and introduced under this trend after integrating the current theories,methods and technologies,and tries theoretic breakthrough in both water transport and logistics research.
Analytical Determination of Fracture Load for Marine Composite Panels

Composites have diversity of structural applications in marine field. For the successful design of damage tolerant composite structures, it is necessary to know the failure mechanism as well as the ability of the structure to carry load after damage initiation. The present paper investigates damage mechanism particularly the interlaminar fracture for composite materials. Fracture load that initiates crack growth on flat rectangular laminate with an embedded delamination has been determined using Virtual Crack Closure Technique (VCCT)  in conjunction with finite element software ANSYS for mode I type loading (opening mode). A MATLAB code has been generated to find fracture load and to plot load –displacement curve using various classical methods.
Hot workability characteristics of as-cast titanium alloy Ti–6Al–2Zr–1Mo–1V: A study using processing map

Abstract The intrinsic workability of as-cast Ti–6Al–2Zr–1Mo–1V alloy was investigated by using processing maps constructed from the stress–strain data generated by isothermal compression tests with a height reduction of 60% over a range of temperatures 1073–1323 K and strain rates 0.01–10 s−1. As the true strain was 0.3, 0.5, 0.7, and 0.9, respectively, the responses of strain rate sensitivity (m-value), power dissipation efficiency (η-value) and instability parameter (ξ-value) to temperature and strain rate were evaluated. By the superimposition of power dissipation and instability maps, the stable and unstable regions were clarified clearly. In further, in the stable area the regions have the highest efficiency of power dissipation (≥0.2) were identified and recommended. On the basis of determination for domains with dynamic recrystallization (DRX) microstructural evolution, the full DRX regions were identified in the processing map at true strain 0.3–0.9. Then not only the domains optimized were validated by DRX refined microstructures, but also the regimes of flow instabilities were validated by the microstructures involving wedge cracking and deformation twinning. The optimal working parameters identified by processing maps and validated by microstructure observations contribute to designing the reasonable hot forming process of Ti–6Al–2Zr–1Mo–1V alloy without resorting to expensive and time-consuming trial-and-error methods.
Synthesis, characterization, bioactivity, and POM analyses of isothiochromeno[3,4-e][1,2]oxazines

A series of 18 new 3,4-disubstituted-isothiochromeno[3,4-e][1,2]oxazines 28–45 has been obtained from the 3′,4′-di-substituted-4′H-spiro[isothiochromene-3,5′-isoxazol]-4(1H)-ones 10–27 in refluxing HCl acid/ethanol. A series of 15/18 compounds 28–45 was selected by the National Cancer Institute (NCI, Bethesda, USA) and were evaluated against a full panel of 60 primary human tumor cell lines derived from nine human cancer types, all of which showed antiproliferative activity in the micromolar range. The most active compound number 37 (S722910) showed high potency against all the tested cell lines with a GI50 mean value in the range of 30–80 μM; TGI and LC50 values were 12–16 μM having positive response on 98 and 63 % of the tested cell lines (Breast-MCF7 and NCS-SF-268) respectively.
The mental economy: testing a dynamic trade-off between internal storage and external sampling

While interacting with the external world, the brain can only represent very little of this world in working memory (WM). WM is therefore generally referred to as a limited-capacity system. This limitation is not a problem in daily life, however, because the external world typically remains available and can be accessed relatively easily. The current dominant theory of WM does not explain how the brain balances between internal storage and external sampling, as this theory exclusively relates to situations in which the remembered information is no longer physically present. The HOMEOSTASIS project is motivated by the idea that WM should be studied in interaction with the world that is still within view. 
HOMEOSTASIS will develop a new theoretical model of WM based on an internal mental economy: I propose that WM maintains a perceptual homeostasis by dynamically trading the costs of accurate internal storage against external sampling of the external visual world. Whereas current research on WM has a strong focus on its maximum capacity, this capacity may hardly be used as observers prefer to minimize internal storage due to the effortful nature of WM storage. 
	I will rigorously test the model’s theoretical basis using novel experimental paradigms in which WM is studied in interaction with the physically present environment. To decode the current content of WM, I will adopt state-of-the-art electroencephalographic decoding techniques. To study WM in interaction with worlds of varying reliability and familiarity, I will employ virtual reality technology. Finally, I will investigate patients with restricted deficits to specific components of the model and use machine learning techniques to discover biometric signatures in eye movements.
	This new model of WM will open a new window to diagnose WM disorders and for understanding how we interact with computer-manipulated virtual environments in an increasingly computer-dominated world.
SYNTHESIS AND ANTIMICROBIAL ACTIVITYOF NOVEL DICATIONIC "REVERSED AMIDINES"

The present invention relates to novel 2,5-bis{[alkyl (or aryl) imino] aminophenyl} furans and thiophenes of the general formula (I) in which R1, R2, R3 and R4 are each independently selected from the group consisting of H, alkyl, alkoxy, halide, and alkylhalide groups; R5 is H, alkyl or aryl; R6 is H, alkyl, aryl, or NR7R8, in which R7 and R8 are each independently selected from the group consisting of H, alkyl and aryl; and X is O, S or NR9, in which R9 is H or alkyl, and to the use of such compounds.
Assessment of the Sampling Performance of Multiple-Copy Dynamics versus a Unique Trajectory

The goal of the present study was to ascertain the differential performance of a long molecular dynamics trajectory versus several shorter ones starting from different points in the phase space and covering the same sampling time. For this purpose, we selected the 16-mer peptide Bak16BH3 as a model for study and carried out several samplings in explicit solvent. These samplings included an 8 μs trajectory (sampling S1); two 4 μs trajectories (sampling S2); four 2 μs trajectories (sampling S3); eight 1 μs trajectories (sampling S4); 16 0.5 μs trajectories (sampling S5), and 80 0.1 μs trajectories (sampling S6). Moreover, the 8 μs trajectory was further extended to 16 μs to have reference values of the diverse properties measured. The diverse samplings were compared qualitatively and quantitatively. Among the former, we carried out a comparison of the conformational profiles of the peptide using cluster analysis. Moreover, we also gained insight into the interchange among these structures along the sampling process. Among the latter, we computed the number of new conformational patterns sampled with time using strings defined from the conformations attained by each of the residues in the peptide. We also compared the locations and depths of the obtained minima on the free energy surface using principal component analysis. Finally, we also compared the helical profiles per residue at the end of the sampling process. The results suggest that a few short molecular dynamics trajectories may provide better sampling than one unique trajectory. Moreover, this procedure can also be advantageous to avoid getting trapped in a local minimum. However, caution should be exercised since short trajectories need to be long enough to overcome local barriers surrounding the starting point and the required sampling time depends on the number of degrees of freedom of the system under study. An effective way to gain insight into the minimum MD trajectory length is to monitor the convergence of different structural features, as shown in the present work.
Phagoscopy: dissecting cell-autonomous immunity with  ex vivo electron cryo-microscopy

Our immune system provides a formidable barrier to the many microbial pathogens that we encounter every day. Yet, many pathogens have the ability to avert this barrier by invading the host cell and seeking shelter inside a phagosome whose membrane physically prevents the pathogen from being recognized and eliminated. Cell-autonomous immunity is a part of the innate immune system that fights off such pathogens. Among the antimicrobial effectors mobilized by this immune response are the Guanylate-Binding Proteins (GBPs). GBPs form dynamic supramolecular assemblies that promote lysis of phagosomes and, thus, killing of pathogens. Despite their central importance, we know very little about the molecular mechanisms of GBPs. Two fundamental questions are: (1) What is the structure and composition of GBP assemblies on membranes?, and (2) Once assembled, how do the GBPs structurally rearrange to reshape and rupture the phagosome's membrane? These questions remain unanswered because structural biology has been lacking methods for determining dynamically changing structures of proteins that are assembled in complex environments such as phagosomes. Here, I propose to take a two-pronged approach to address these questions: first, I will use cryo-EM and (single-molecule) fluorescence microscopy to elucidate the interactions and conformational changes involved in GBP oligomerization on model membranes. Second, I will visualize this pathway on native phagosomes using a recently developed ex vivo reconstitution system unique to my laboratory. By determining how GBP assemblies form on phagosome membranes, how they reshape the membrane so that it ruptures, and how these processes can be regulated and inhibited, I will derive a mechanistic model of a key effector function that cells employ to combat disease-causing pathogens. More broadly, my study will establish a novel approach for integrative imaging that will be applicable to a wide range of dynamic molecular assemblies in cells.
BEVERAGE DISPENSING VALVE SYSTEM

A post-mix beverage dispenser utilizing a beverage dispensing valve including a movable valve activation device is provided. The beverage dispensing valve can move the valve activation device to a predetermined activation position to dispense a fluid in response to a control signal.
Hybrid social and news media protest events: from #MarchinMarch to #BusttheBudget in Australia

ABSTRACTPublic protest events are now both social media and news media events. They are deeply entangled, with news media actors – such as journalists or news organisations – directly participating in the protest by tweeting about the event using the protest hashtag; and social media actors sharing news items published online by professional news agencies. Protesters have always deployed tactics to engage the media and use news media agencies’ resources to amplify their reach, with the dual aim of mobilising new supporters and adding their voice to public, mediatised debate. When protest moves between a physical space and a virtual space, the interactions between protesters and media stop being asynchronous or post hoc and turn instantaneous. In this new media-protest ecosystem, traditional media are still relevant sources of information and legitimacy, yet this dynamic is increasingly underpinned by a hybrid interdependency between traditional news and social media sources. In this paper we focus on an a...
Laser induced synthesis of biocompatible multifunctional inorganic nanoparticles: a novel route to produce multifunctional contrast agents for early diagnosis of breast cancer

The main goal of this IF research proposal is to produce novel nanoparticle-based multimodal contrast agents for their use in breast cancer diagnosis by combining Magnetic Resonance Imaging, Digital Mammography, X-ray Computed Tomography and Ultrasonography. In doing so, we will develop a new high-productivity strategy to synthesize multimodal hybrid nanoparticles, which consists in femtosecond-laser-induced-ablation of a metal plate immersed into a solvent containing chemicals, in combination with direct nanosecond-laser photolysis in solution of these chemicals. This research will be coupled to an in situ study of the high-productivity laser fabrication process and the analysis of the underlying mechanisms which allows the nucleation and growth of these hybrid nanoparticles. Moreover, we will analyze the structure, composition, physical and colloidal properties of the as-synthesized hybrid nanoparticles, as well as the in vitro performance of these nanoparticles as contrast agents in Magnetic Resonance Imaging, Ultrasonography and X-ray imaging techniques. We will also evaluate the citotoxicity of the as synthesized hybrid nanoparticles in normal cells and tumor breast cells lines. Finally, we will target these nanoparticles toward the human epidermal growth factor receptor 2 (HER2) which is overexpressed in breast cancers with a poor prognosis and higher disease recurrence, and we will evaluated in vitro the targeting ability of the obtained anti-HER2-nanoparticles conjugates for HER2+ breast cancer cells.