SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Development of pellets for oral lysozyme delivery by using a quality by design approach

Abstract The concept of Quality by design is of increasing importance in the pharmaceutical industry, especially in the development of biotechnologically produced active pharmaceutical ingredients (APIs). These proteins/peptide-like materials are usually more sensitive than small molecules to the environmental and process parameters. The objectives of the presented study were to identify how the critical process parameters influence the critical quality attributes (CQAs) of a lysozyme-containing multiparticulate dosage form, and to determine the critical points of API activity preservation. The experiments were performed according to a 26 factorial design. The process parameters were recorded with Process Analytical Technology tools, based on in-line mixing speed, mixer torque and temperature measurements and at-line moisture content analysis. The hardness and geometry of the pellets, and the activity of the API were studied as CQA. Complex relationships were identified between the CQAs and process parameters, and the thermomechanical effects and the liquid distribution inside the mass during the texture-forming steps of the process were found to exert considerable effects on the mechanical and geometrical properties and also basically to determine the API activity.
Paziente che ha tentato il suicidio

Il suicidio, responsabile di circa 10 500 decessi in Francia ogni anno, con quasi 200 000 tentativi di suicidio registrati, costituisce un grave problema di salute pubblica. Il rischio di decesso per suicidio è maggiore negli uomini che nelle donne e negli anziani rispetto ai giovani. La presenza di una comorbilità psichiatrica o somatica aumenta il rischio di recidiva suicidaria. Più dell’80% dei pazienti che tentano un suicidio passa attraverso un Pronto Soccorso. Solo un quarto di essi sarà ricoverato in un reparto psichiatrico. La gestione dei suicidi nel Pronto Soccorso ospedaliero è svolta in maniera multidisciplinare. A causa dell’amnesia secondaria all’intossicazione farmacologica volontaria, le persone che hanno tentato il suicidio che non sono ricoverate in reparti psichiatrici dovrebbero poter rimanere abbastanza a lungo al Pronto Soccorso, in modo da pianificare la prosecuzione del trattamento. Si ritiene che il 10% dei soggetti che hanno tentato il suicidio finisca per decedere per suicidio nei dieci anni successivi a tale tentativo. Un approccio preventivo si rivela quindi indispensabile quando una persona ha tentato il suicidio. Questo problema costituisce un paradigma d’elezione per una riflessione sulla missione di prevenzione dei servizi di Pronto Soccorso.
Effect of sodium chloride on the structure and stability of spider silk's N-terminal protein domain

A spider's ability to store silk protein solutions at high concentration is believed to be related to the protein's terminal domains. It has been suggested that a shift in salt concentration and pH can have a significant influence on the assembly process. Based on experimental data, a model has been proposed in which the N-terminal domain exists as a monomer during storage and assembles into a homodimer upon spinning. Here we perform a systematic computational study using atomistic, coarse-grained and well-tempered metadynamics simulation to understand how the NaCl concentration in the solution affects the N-terminal domain of the silk protein. Our results show that a high salt concentration, as found during storage, weakens key salt bridges between the monomers, inducing a loss in bond energy by 28.6% in a single salt bridge. As a result dimer formation is less likely as 35.5% less energy is required to unfold the dimer by mechanical force. Conversely, homodimer formation appears to be more likely at low salt concentrations as the salt bridge stays at the lower energy state. The link between salt concentration, structure and stability of the N-terminal domain provides a possible mechanism that prevents premature fiber formation during storage.
SP35 ANTIBODIES AND USES THEREOF

Endogenous Sp35 is a negative regulator for neuronal survival, axon regeneration, oligodendrocyte differentiation and myelination. Molecules that block endogenous Sp35 function, such anti-Sp35 antibodies can be used as therapeutics for the treatment of neuron and oligodendrocyte dysfunction. The present invention provides antibodies specific for Sp35, and methods of using such antibodies as antagonists of endogenous Sp35 function. The invention further provides specific hybridoma and phage library-derived monoclonal antibodies, nucleic acids encoding these antibodies, and vectors and host cells comprising these antibodies. The invention further provides methods of promoting oligodendrocyte survival and myelination in a vertebrate, comprising administering to a vertebrate in need of such treatment an effective amount of an anti-Sp35 antibody.
Breakthrough of hydrogen energy and hydrogen mobility by utilisation of membrasenz membranes

Advanced material for separating hydrogen (H2) and oxygen, during H2 production in alkaline electrolysers, has been developed by the Start-up company MEMBRASENZ. Taking into account the relevance of H2 as a future energy career in providing green, CO2-free energy supply for industrial, domestic use and mobility applications, this invention possesses the potential to contribute solving the future European/global energy challenges. The target customers of the innovative membrane material are worldwide manufacturers of alkaline electrolysers. Ten companies have already, with a Letter-of- Intent, expressed their interest in installing the patented MEMBRASENZ membranes in their systems. The State-of-the-Art membranes available on the market, Zirfon® (AGFA), possess shortcomings, which are limiting the expansion of the alkaline water electrolysis for H2 production. The prototype membrane (TRL 7) developed by MEMBRASENZ surpasses the performance of the competitor on the market. Ionic conductivity, thermal and mechanical resistivity of MEMBRASENZ prototype membranes are significantly higher compared to the State-of-the-Art membrane. These improvements lead to increased efficiency of the electrolysis process when using MEMBRASENZ membranes and would enable the reduction of the H2 price.
The assessment of the suitable technology for the prototype up-scale in industrial conditions (wet and dry impregnation trials), assessment of the EU, CH and USA market, IP protection strategy, as well as the elaboration of a feasibility report with a business plan, are defined as the objectives of the feasibility study. To attain the main objectives of the overall innovation project i.e. launch of the pilot and mass membrane production, market entry with the membrane product and business growth accompanied with hiring personnel, MEMBRASENZ intends to also apply for Phase 2. The outcome for the EU and society will be the breakthrough of CO2-free hydrogen technologies.
Effects of concentration and propagule age on the efficacy of gibberellic acid for breaking dormancy in potato minitubers

SummaryThe effects of a post-harvest application of gibberellic acid (GA3) at various concentrations (0, 10, 25, 50, or 100 mg l–1) and for different periods of incubation (1, 2, or 3 h) on the breaking of dormancy and on sprouting in potato (Solanum tuberosum L., cv. Marfona) minitubers of two ages (freshly-harvested or 1 week after harvest) were investigated. Compared with untreated, control minitubers, GA3-treated minitubers showed a significantly shorter period of dormancy (46 d), especially when the minitubers were treated at all concentrations immediately after harvest (41 d). GA3 treatment had a greater effect on dormancy in freshly-harvested minitubers than in 1 week-old minitubers, probably because of the reduced uptake of GA3 solution after skin-set. At lower concentrations of GA3, the period of dormancy tended to decrease the longer the minitubers were immersed in the GA3 solution. In contrast, at higher concentrations of GA3, the duration of immersion only had an effect up to 2 h and any longe...
Dyme gives its users complete control over their financial situation. the dyme application provides insight into users’ spending and subscriptions, and lets users cancel, negotiate, or switch any cont

Dyme introduces an application that enables consumers to take complete control over their financial situation.

The number of paid subscriptions per person is increasing rapidly. As a result, consumers experience a lack of overview, and find it increasingly difficult to manage their finances. This is evident in the fact that 53% of the people between 18 and 35 forget to cancel at least one unwanted subscription annually (Nibud, 2018). Furthermore, switching an negotiating between providers on a yearly basis is lucrative for consumers, yet perceived to be a substantial effort. 

It is increasingly difficult to manage expenses. People are trying to save money, while unknowingly paying for subscriptions they do not use. Switching, cancelling or renegotiating contracts on a yearly basis can save customers €720 per year.

Dyme introduces an application that enables consumers to take complete control over their recurring expenses. Users connect their bank account, and Dyme uses machine learning techniques to detect their memberships. Thereafter, users can switch or cancel subscriptions with a single click. There is currently no application that provides a complete overview of all recurring expenses and provides its users an instant mechanism to act on this information. Dyme offers a solution that is both innovative and convenient and accessible for all Europeans.
Coordination of Supply and Demand Network in the Presence of Reverse Logistics and Asymmetric Information

The paper analyzes the coordination and efficiency of a two-tiers assembly supply and demand system,in which the reverse logistics exist as a result of the sharing of the salvage value of the left-over inventories.In the presence of the reverse logistics and asymmetric information,our research indicates that the traditional revenue-sharing contract cannot effectively coordinate the supply chain.Furthermore,under the sharing contract for the system with competition and signaling,our analysis through establishing the newsvendor model separately for every party of the supply chain implies that the effective coordination can only be achieved through introducing the signaling mechanism and suppliers' competition of the same kind of products simultaneously,plus the incentive for a long-term relationship.Our conclusion is justified through a computational study,and is consistent with the original meaning of supply and demand network.
Removal of the fractured implant abutment screw: A case report

In clinical practice day to day increase in the prosthetic replacement with implants has made the dentist a regular user of implant systems. From placement to rehabilitation it is a hard task to perform and even harder is to get the performance of the replaced prosthesis. Encountering problems in the implant retained prosthesis is more common after loading. The failure of dental implants is due not only to biological factors, such as unsuccessful osseointegration or the presence of peri-implantitis, but may also result from technical complications. The abutment screw fracture represents a rare, but quite unpleasant failure. Several factors have been implicated in the etiology of these technical failures, including excessive occlusal load, fatigue, improper placement techniques, non-passive fit of the suprastructures. Retrieval of the fractured abutment screw and to use the well osseointegrated implant represents a challenging aspect in implant dentistry.
A revolutionary approach to mechanical transmission: the new gear-free, lubrication-free gearbox

The gearbox is a mechanical method of transferring energy from one device to another and used to increase torque while reducing speed. In some sectors, e.g. pharmaceutical and food & beverage, sensitive and sterile environment conditions apply, as such gearboxes used must comply with very strict sanitary rules. Currently, state-of-the-art gearbox systems work with lubrification to reduce friction, wear & transfer heat to avoid local high temperature areas. Yet, proper lubrification is associated with high costs of labour, downtime, maintenance, disposal and purchase, as well as high risk of atmosphere/product contamination. The latter being extremely damaging in sterile and controlled environment (e.g. pharmaceutical product manufacture). 
To address these challenges, We, Poggi Trasmissioni Meccaniche, a top EU leader in manufacturing transmission system, has developed P-Gear: our new range of innovative transmission, 100% clean, silent and virtually maintenance-free. It consists of two rotors – the driven one and the driving one – both elements being equipped with a permanent magnet. Thanks to our specific distribution of the magnets, it is possible to obtain speed transmission and speed decrease without contact between the rotors, thus eliminating the need for lubrication. 
Adaptable in all power transmissions applications by replacing traditional “contact” systems, our technology is set to revolutionize the world of mechanical gear drives. The targeted field is promising: the global industrial gearbox market is expected to grow from €23.6 billion in 2017 to €38.8 billion by 2026, at a 5.9% CAGR. Focusing on the stringent pharmaceutical and food & beverage market niches, using P-Gear will ensure safety by eliminating the lubricant, while providing also a higher efficiency and low wear & tear due to the reduced heat generated. Within 5 years of P-Gear exploitation, we expect to reach revenues of €15M while creating 16 new jobs.
Penguatan Budaya Nasional Dalam Situasi Krisis Budaya (Jurnal Ilmiah Bestari, No42/thXXII/September-Desember 2009

There is something wrong in cur edueationsystemt Our educatisn do uot give'chanee to appreciate and learuculture' *ducation on culture'is donc more on cagnitive aspec{ students are taught names both local and national cultures, folk dances' folk ,orrgr, nidturious traditions from many places in Indonesia without comprehending the real meaning of the culture itself' Furthermore' poptareactuatlytheculturelegalorrner.Ifthisunderstandingis .i.oog urrough, claims-on our cultures by another countr-v will never nappen. Ttre most important is how to establish and teach people so ttrat ttrey have sense of belonging to their orvn cultures' So' it is time for ceniral and local go'ernments facilitate public's participation in national culture affi rmation'
Dielectric functions and carrier concentrations of Hg1−xCdxSe films determined by spectroscopic ellipsometry

Spectroscopic ellipsometry, ranging from 35 meV to 6 eV, was used to determine the dielectric functions of a series of molecular beam epitaxy-grown Hg1−xCdxSe thin films deposited on both ZnTe/Si(112) and GaSb(112) substrates. The fundamental band gap as well as two higher-order electronic transitions blue-shift with increasing Cd composition in Hg1−xCdxSe, as expected. Representing the free carrier absorption with a Drude oscillator, we found that the effective masses of Hg1−xCdxSe (grown on ZnTe/Si) vary between 0.028 and 0.050 times the free electron mass, calculated using the values of carrier concentration and the mobility obtained through Hall measurements. Using these effective masses, we determined the carrier concentrations of Hg1−xCdxSe samples grown on GaSb, which is of significance as films grown on such doped-substrates posit ambiguous results when measured by conventional Hall experiments. These models can serve as a basis for monitoring Cd-composition during sample growth through in-situ sp...
Renewability and emergy footprint at different spatial scales for innovative food systems in Europe

Food production is increasingly being challenged by limited resources of energy and land as well as by growing demand for food. In a future with less availability of fossil fuels, land area will become very important for capturing the flow-limited renewable resources. Emergy assessment has been applied to calculate scale dependent indicators, which account for the land area needed, if agricultural systems were to be supported solely on renewable sources. These indicators are designated emergy footprints (EmFs) and expand the concept of support area defined previously in emergy accounting. The EmF (in ha) is calculated based on renewable empower densities which convert resource use into area equivalents able to capture renewable flows. The spatial division between on-site, local and non-local land areas applied in this study, identifies where the support area is located in order to apply a site-specific renewable empower density. A new indicator applying the EmF is the emergy overshoot factor, which estimates the ratio between EmF and the geographical system boundary (in ha). We apply this approach on three innovative food supply systems in Europe located at farms characterised by combining high diversity, reduced use of resources, nutrient cycling and local sales. The question is whether this type of food system may be considered sustainable from a resource use point of view measured as resource use efficiency by means of unit emergy value (UEV), renewability (Ron-site and Rglobal), direct and indirect occupation of land on different spatial scales (EmF and Emergy overshoot factor) and productivity per ha of the directly observed areas and the EmF area, respectively. Labour inputs constituted between 13 and 80% of the total emergy flow. The proportion of resource use from renewable sources was between 31 and 60% when excluding the inputs of direct labour. The food system with the lowest UEV, excluding direct labour, had the highest emergy overshoot factor, which even exceeded the global average of seven. However, this system had the highest productivity. The system with the highest UEV, excluding direct labour, had the lowest overshoot factor. In conclusion, each food system strategy has its pros and cons and it depends on the priorities, which is judged the most sustainable from an emergy point of view.
BACTERIAL SYSTEM FOR PROTEIN TRANSPORT IN EUKARYOTIC CELLS

The aim of the invention is to develop a system for the targeted transport of proteins into eukaryotic cells. The specific transport of proteins into eukaryotic cells is carried out using a type III secretion system, using bacteria strains that are mutated in hpaB or homogenous genes. A non-pathogenic strain is generated from a Gram-negative pathogenic bacteria strain, said non-pathogenic strain being mutated in the hpaB-gen or a homogenous gene which does not mediate any significant translocation of bacterial effector proteins. Over-expressed effector proteins or proteins containing the type 111 secretion signal of a non-effector protein can, however, be translocated into eukaryotic cells using the bacterially inherent TTSS. The inventive bacterial system is used to transport bacterial proteins into eukaryotic cells, in order to influence or modify cellular processes such as gene expression, growth, development and defence/resistance mechanisms.
Operational optimisation of a tidal barrage across the Mersey estuary using 0-D modelling

With the operational lifetime of a tidal barrage stretching up to 120 years, it is important to be able to change the level of energy generation with varying trends in energy demand. Unlike other technologies, the energy generation level and sequence of a tidal barrage can be significantly altered without any physical change to the barrage by varying only the operational parameters. In order to explore this, a computational model which calculates the energy generation for a barrage across the Mersey estuary was developed. The model uses cutting edge double regulated turbine technology and bathymetric data and explores how this can be achieved without changing the physical parameters of the barrage. The derived results were compared to previous studies and found to match and exceed the results of past predictions.
Momentum routing invariance in Feynman diagrams and quantum symmetry breakings

We illustrate with examples that quantum symmetry breakings in perturbation theory are connected to breakdown of momentum routing invariance (MRI) in the loops of a Feynman diagram. We show that MRI is a necessary and sufficient condition to preserve abelian gauge symmetry at arbitrary loop order. We adopt the implicit regularization framework in which surface terms that are directly connected to momentum routing can be constructed to arbitrary loop order. The interplay between momentum routing invariance, surface terms and anomalies is discussed. We also illustrate that MRI is important to preserve supersymmetry. For theories with poor symmetry content, such as scalar field theories, MRI is shown to be important in the calculation of renormalization group functions.
A disruptive innovation in mobile marketing and business intelligence for drastically increasing smes competitiveness

GIGIGO envisions becoming the leading business intelligence and mobile marketing provider for SMEs in the retailing field, through the development of a low cost and highly scalable product that will allow any SME to design, monitor and exploit advanced business intelligence (BI), big data analysis and mobile marketing tools that currently are only affordable by large industrial players. ORCHEXTRA pricing scheme makes the service one hundred times cheaper than current tailor-made solutions. 
ORCHEXTRA intends to transform the way in which SMEs drive their marketing strategies and exploit business intelligence tools. ORCHEXTRA will provide comprehensive support to SMEs in: 
• Smart Packaging. Enhance the information and services provided within the product packaging through barcode scanning, promotions, engagement & fidelity measures, etc. 
• Image recognition. Barcodes (2D codes, datamatrix, EAN…) and also image recognition (brand logo, bottle, can…).
• Intelligence layers. Big Data, Machine Learning, Customer behavioural patterns. Business intelligence, Triggers (demographic info, location, CRM…). Intelligence layers will be based on the analysis of aggregated anonymised data from all the platform customers creating a truly cooperative big data platform for SMEs.
• Consumers’ behaviour. Gain a much deeper knowledge on final customers, their purchasing processes, complementary products, demographic profile.
• Proximity marketing. Geofencing (outdoor), Beacon (indoor & outdoor).
• Personalized actions. Push notifications. Web mobile (content, promo, survey...). User Generation content (likes, comments, retweet…). Purchase/Order. Rewards and coupons. 
Granting SMEs access to such high-added value services will enhance their competitiveness and contribute to the creation of growth and jobs in Europe. With this project we will contribute to transmit one fundamental idea: Every organisation is capable of innovating whatever their activity, size or situation.