SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Advanced Therapies Experiences

ATEX project aims at activating a new cross-border platform to transfer innovative ideas to the market in the field of advanced therapies. This knowledge platform intends to translate ideas into advanced products for the treatment of various chronic diseases. Through ATEx, different organizations working between Ticino and Lombardy on the combination of biomaterials of various origins (animal or human) and stem cells or their derivatives will be networked. In particular, the project aims to promote the development of new solutions, identify subjects capable of dealing with regulatory aspects and financing, and systematically transfer this knowledge to the market.
Flywheel energy storage for increased grid stability

In recent years, the energy transition towards renewables has significantly accelerated. Germany is shutting down nuclear power plants and the fate of coal-fired power plants has been determined by the climate agreement in Paris. In short - fossil fuels will be replaced by renewable technologies. This is in line with the Renewable Energy Directive, that requires the EU to provide 27% of its energy generation from renewables by 2030.

Adaptive has developed a unique energy storage solution offering a short-term, high-power output. This has been identified as the most efficient way to stabilize the power grids. Transmission system operators need the flywheel to find a balance between energy generation and consumption. This allows electricity grids to operate without conventional power plants while keeping the grid stable.

This project will investigate the business cases for dynamic grid balancing with the innovative and adaptive flywheel by questioning key stakeholders in several markets. The flywheel is modular and offers unparalleled configurability in terms of power to energy ratio, which makes it the first dynamic energy storage system whose discharge duration can be matched exactly to the customer’s needs.

After the feasibility assessment, Adaptive will apply for Phase 2 funding to build a pilot installation outside of Central Europe. This enables the company to further scale up its business and increase its revenue while allowing the creation of new jobs along the supply chain and providing a high return to the EU economy. In addition to that, it allows for a global reduction of CO2-emissions by increasing the permissible share of renewable energy in electricity grids.
PROCESS FOR A FIXED FILM REACTOR AND APPARATUS RELATED THERETO

Exemplary embodiments describe apparatuses and related processes for improving mixing and sheer in a fixed film reactor. One process can include recycling at least a portion of a biogas product through at least one sparger below a fixed film zone in the fixed film reactor at conditions sufficient for mixing and sheering the film from an internal structure within the fixed film zone. Often, a cross-sectional area of the fixed film zone fills at least about 90% of a cross-sectional area of the fixed film reactor.
LEITURAS E ESCRITAS DO CINEMA NA ESCOLA DE EDUCAÇÃO INFANTIL: EXPERIÊNCIAS DE CRIAÇÃO COM OS FEMININOS

Apresentaremos algumas cartografias femininas esboçadas em uma pesquisa em andamento. Foram tecidas a partir de leituras e experimentações com a multiplicidade de textos e filmes produzidos pelas educadoras e pesquisadoras do Cineclube de duas escolas públicas de educação infantil de Campinas.
PROJEKTCODE: 16871 – POR MARCHE FESR 2014/2020 ACHSE 8 OS 21 – AKTION 21.1 – INTERVENTION 21.1.1 – UNTERSTÜTZUNG PRODUKTIVER INVESTITIONEN ZUR FREISETZUNG VON WIRTSCHAFTSWACHSTUM UND WETTBEWERBSFÄHIGKEIT DER VOM ERDBEBEN BETROFFENEN GEBIETE

PROJEKTCODE: 16871 – POR MARCHE FESR 2014/2020 ACHSE 8 OS 21 – AKTION 21.1 – INTERVENTION 21.1.1 – UNTERSTÜTZUNG PRODUKTIVER INVESTITIONEN ZUR FREISETZUNG VON WIRTSCHAFTSWACHSTUM UND WETTBEWERBSFÄHIGKEIT DER VOM ERDBEBEN BETROFFENEN GEBIETE
A Characterization of Bergman Spaces on the Unit Ball of ℂn. II

Abstract It has been shown that a holomorphic function f in the unit ball of ℂ n belongs to the weighted Bergman space , p &gt; n + 1 + α, if and only if the function | f ( z ) – f ( w )|/|1 – 〈 z , w 〉| is in L p ( × , dv β × dv β ), where β = ( p + α – n – 1)/2 and dv β ( z ) = (1 – | z | 2 ) β dv ( z ). In this paper we consider the range 0 &lt; p &lt; n + 1 + α and show that in this case, f ∈ (i) if and only if the function | f ( z ) – f ( w )|/|1 – h z , w i| is in L p ( × , dv α × dv α ), (ii) if and only if the function | f ( z )– f ( w )|/| z – w | is in L p ( × , dv α × dv α ). We think the revealed difference in the weights for the double integrals between the cases 0 &lt; p &lt; n + 1 + α and p &gt; n + 1 + α is particularly interesting.
A METHOD FOR MANUFACTURING BIODEGRADABLE PACKAGING MATERIAL, BIODEGRADABLE PACKAGING MATERIAL AND A PACKAGE OR A CONTAINER MADE THEREOF

The invention provides a biodegradable packaging materi- al, a method of manufacturing the same, as well as products made of the material. The manufacture comprises extrusion onto a fibrous substrate (1) one or more polymer coating layers including at least one layer (2) of a polymer blend consisting of (i) 20–95 wt-% of polylactide having a high melt index of more than 35 g/10 min (210 °C; 2.16 kg), (ii) 5–80 wt-% of polybutylene succinate (PBS) or a biodegradable derivate thereof, and (iii) 0–5 wt-% of one or more polymeric additives. The components of the blend are melted and blended in connection with the extrusion step. The goal is to improve extrudability, increase ma- chine speed in extrusion and maintaining good adhesive- ness to the substrate and good heat-sealability of the coat- ing. The products include disposable drinking cups and board trays, as well as sealed carton packages for solids and liquids.
Feasibility of Web-Based Self-Triage by Parents of Children With Influenza-Like Illness

Self-triage using web-based decision support could be a useful way to encourage appropriate care-seeking behavior and reduce health system surge in epidemics. However, the feasibility and safety of this strategy have not previously been evaluated.To assess the usability and safety of Strategy for Off-site Rapid Triage (SORT) for Kids, a web-based decision support tool designed to translate clinical guidance developed by the Centers for Disease Control and Prevention to help parents and adult caregivers determine if a child with influenza-like illness requires immediate care in an emergency department (ED).Prospective pilot validation study conducted between February 8 and April 30, 2012. Staff who abstracted medical records and made follow-up calls were blinded to the SORT algorithm's assessment of the child's level of risk.Two pediatric emergency departments in the National Capital Region.Convenience sample of 294 parents and adult caregivers who were at least 18 years of age; able to read and speak English; and the parent or legal guardian of a child 18 years or younger presenting to 1 of 2 EDs with signs and symptoms meeting Centers for Disease Control and Prevention criteria for influenza-like illness.Completion of the SORT for Kids survey.Caregiver ratings of the website's usability and the sensitivity of the underlying algorithm for identifying children who required immediate ED management of influenza-like illness, defined as receipt of 1 or more of 5 essential clinical services.Ninety percent of participants reported that the website was "very easy" to understand and use. Ratings did not differ by respondent race, ethnicity, or educational attainment. Of the 15 patients whose initial ED visit met explicit criteria for clinical necessity, the Centers for Disease Control and Prevention algorithm classified 14 as high risk, resulting in an overall sensitivity of 93.3% (exact 95% CI, 68.1%-99.8%). Specificity of the algorithm was poor.This pilot study suggests that web-based decision support to help parents and adult caregivers self-triage children with influenza-like illness is feasible. However, prospective refinement of the clinical algorithm is needed to improve its specificity without compromising patient safety.
Reversible causally-consistent debugging of concurrent programs

Modern computing devices execute complex software to provide every-day services and applications. The development of such software is challenging, time consuming and costly. It involves writing a program code, testing it and debugging it, namely finding an error in the code and correcting it. It is estimated that debugging costs an estimated 312 billion USD a year. The most successful commercial debugging tools are reversible debuggers. They allow the users to undo an execution of a faulty program, to find and correct errors, and then to run the corrected code forwards again. UndoDB by Undo Software is the top reversible debugger currently on the market. However, even the best reversible debuggers are not suited very well to debugging of concurrent programs. Moreover, it is not universally agreed yet how to reverse the code of concurrent or distributed software. This project aims at addressing these shortcomings by exploiting the promising notion of causally-consistent reversibility as the basis for reversible debugging tools. Novel formal models and new techniques for recording, analysis and replay of concurrent programs will be created. An execution engine for the shared-memory and message-passing styles of programs will be developed in a close collaboration with Undo Software and Erlang Solutions, the leading software companies. The scientific outcomes will be turned into an experimental prototype software, called Reversible CAusally-consistent DEbugger (RCADE), which will extend and enhance commercial debugging tools, especially for concurrency.

The Fellow will undertake a world-class programme of research, industrial and academic training and collaboration. He will obtain formal lecturer qualification and deliver an undergraduate module. The knowledge and experience gained on the fellowship will be transferred to academia and industry in Europe. The project will develop his scientific independence, create a new network and enforce a senior academic position.
Fair enough

We consider the problem of fairly allocating indivisible goods, focusing on a recently-introduced notion of fairness called maximin share guarantee: Each player's value for his allocation should be at least as high as what he can guarantee by dividing the items into as many bundles as there are players and receiving his least desirable bundle. Assuming additive valuation functions, we show that such allocations may not exist, but allocations guaranteeing each player 2/3 of the above value always exist, and can be computed in polynomial time when the number of players is constant. These theoretical results have direct practical implications.
Voltage control of PV-Rich LV networks: OLTC-fitted transformer and capacitor banks

Due to the increasing adoption of domestic photovoltaic (PV) systems, the use of technologies such as on-load tap changer (OLTC)-fitted transformers, capacitor banks, and remote monitoring are being considered to mitigate voltage issues, particularly in European-style low voltage (LV) networks. Depending on the control strategy, however, the effects on customer voltages and control actions (e.g., tap changes or capacitor switching) can vary significantly. This work presents a framework to assess the performance of different OLTC-based control strategies in terms of voltage compliance with the standard BS EN50160 and the number of control actions. Three control strategies are proposed: constant set-point (CSC), time-based (TBC) and remote monitoring-based (RMC). A week-long Monte Carlo analysis is carried out considering a real UK LV network, three-phase power flows, different PV penetrations and seasonality. Results show that the TBC outperforms the CSC but at the expense of more tap changes. Due to the enhanced visibility, the RMC significantly increases the PV hosting capacity whilst limiting tap operations. Finally, when feeders have contrasting voltage issues, capacitor banks are found to provide additional flexibility and allow higher PV penetrations. These findings are expected to help the industry determining the benefits from OLTC-based solutions in future LV networks.
Educators’ Insights in Using Chronicle Diabetes

Purpose Diabetes educators lack data systems to monitor diabetes self-management education processes and programs. The purpose of the study is to explore diabetes educator’s insights in using a diabetes education data management program: the Chronicle Diabetes system. Methods We conducted 1 focus group with 8 diabetes educators who use the Chronicle system in western Pennsylvania. The focus group was audiotaped and transcribed verbatim. Themes were categorized according to system facilitators and barriers in using Chronicle. Results Educators report 4 system facilitators and 4 barrier features. System facilitators include (1) ability to extract data from Chronicle for education program recognition, (2) central location for collecting and documenting all patient and education data, (3) capability to monitor behavioral goal setting and clinical outcomes, and (4) use of a patient snapshot report that automatically summarizes behavioral goal setting and an education plan. Barriers reported are (1) initially time-consuming for data entry, (2) Health Insurance Portability and Accountability Act privacy concerns for e-mailing or downloading report, (3) need for special features (eg, ability to attach a food diary), and (4) need to enhance existing features to standardize goal-setting process and incorporate psychosocial content. Conclusions Educators favor capabilities for documenting program requirements, goal setting, and patient summaries. Barriers that need to be overcome are the amount of time needed for data entry, privacy, and special features. Diabetes educators conclude that a data management system such as Chronicle facilitates the education process and affords ease in documentation of meeting diabetes self-management education standards and recognition requirements.
New methods for analyzing serological data with applications to influenza surveillance

For decades, the hemagglutination-inhibition (HI) assay has been used in epidemiological and basic biological studies of influenza viruses. The mechanistic basis of the assay results (called titers) is not well understood. The first part of this document describes a biophysical model of HI that illuminates the mechanistic basis of and provides the theoretical motivation for new ways of interpreting titers. The biophysical model is applicable to other serological assays; this fact is illustrated using the neutralization assay. The second part of the document describes some new ways of interpreting titers, which involve, among other methods, singular value decomposition and probabilistic multidimensional scaling. The third part of the document discusses biological and mathematical issues related to the determination of the effective dimensionality of titers, and describes an algorithm for recovering unavailable titers.
Evaluation of a real-time polymerase chain reaction assay for the laboratory diagnosis of giardiasis

A real-time polymerase chain reaction (PCR) assay was evaluated in comparison with the combination of conventional methods (microscopic examination and antigen detection assay) during the period 2006 to 2008 on 771 fecal samples belonging to 386 patients to assess its usefulness for an accurate laboratory diagnosis of giardiasis. The real-time PCR assay detected Giardia intestinalis DNA in 195 samples (106 patients), including 26 samples (21 patients) negative by the conventional assays. Among the 21 patients, in 8 cases, giardiasis was previously diagnosed also by conventional methods in additional samples of the same patients, whereas in 13, it would have been undiagnosed if real-time PCR assay was not used. The real-time PCR assay demonstrated a detection limit of 2 cysts per reaction and 100% specificity and sensitivity compared to conventional methods. A genotype analysis targeting the beta-giardin gene allowed to identify 53 samples (23 patients) containing genotype A and 59 samples (45 patients) containing genotype B.
VEGETABLE HEALTH DRINK

An oat based vegetable health drink comprises or substantially consists of carbohydrate of high glycemic index (GI) from oats, inherent oat protein, β-glucan, potato protein or other protein of vegetable origin of a composition similar to that of potato protein, and water but does not contain any of: protein of animal origin, trimethylglycine, hydrocolloid other than β-glucan. Also disclosed is a method of promoting muscle glycogen recovery upon physical exertion by administration of a glycogen recovery efficient amount of the health drink in close timely proximity of the exertion.
Behavioral Program Logic

We present Behavioral Program Logic (BPL), a dynamic logic for trace properties that incorporates concepts from behavioral types and allows reasoning about non-functional properties within a sequent calculus. BPL uses behavioral modalities Open image in new window , to verify statements Open image in new window against behavioral specifications \(\tau \). Behavioral specifications generalize postconditions and behavioral types. They can be used to specify other static analyses, e.g., data flow analyses. This enables deductive reasoning about the results of multiple analyses on the same program, potentially implemented in different formalisms. Our calculus for BPL verifies the behavioral specification gradually, as common for behavioral types. This vastly simplifies specification, calculus and composition of local results. We present a sequent calculus for object-oriented actors with futures that integrates a pointer analysis and bridges the gap between behavioral types and deductive verification.
PROSTHETIC LEAFLETS FOR VALVE REPLACEMENT

A prosthetic heart valve includes a support structure and a valve assembly disposed within the support structure, the valve assembly including a plurality of leaflets. Each leaflet is formed from a predetermined leaflet material. Some leaflet materials include a metal body with a plurality of openings. The metal body may be coated with a polymer. Other leaflet materials include natural mammalian tissue subjected to a plastination preservation process.
Maria Montessori's Epistemology

This paper lays out the epistemology of Maria Montessori (1870–1952). I start with what I call Montessori's ‘interested empiricism’, her empiricist emphasis on the foundational role of the senses combined with her (broadly Jamesian) insistence that all cognition is infused with ‘interest’. I then discuss the unconscious. Partly because of her emphasis on early childhood, Montessori puts great emphasis on unconscious cognitive processes and develops a conceptual vocabulary to make sense of the continuity between conscious and unconscious processes. The final sections turn to two brief but important applications of this general epistemic framework, the importance of ‘meditation’ as an epistemic practice and Montessori's accounts of epistemic virtues.
β-CD-catalyzed multicomponent domino reaction: synthesis, characterization, in silico molecular docking and biological evaluation of pyrano[2,3-d]-pyrimidinone derivatives

Simple and green synthetic procedures constitute an important goal in organic synthesis. The combination of multicomponent reactions (MCRs) and unconventional solvents has become a new research direction, which enables simultaneous growth of both MCRs and green solvents toward ideal organic synthesis. In this paper, we have summarized recent results of MCRs obtained in unconventional media using water and β-cyclodextrin, as supramolecular catalyst, for the synthesis of pyrano[2,3-d]-pyrimidinone (4a–q) derivatives. The compounds were evaluated for their in vitro antimicrobial activity. Among the synthesized compounds, compounds 4h, 4m and 4p exhibited higher antimicrobial activity than ciprofloxacin used as the reference drug. Most of the synthesized compounds have good to excellent antimicrobial activity. Furthermore,  molecular docking study was performed to help understand binding interactions of the most active analogs with C30 carotenoid dehydrosqualene synthase enzyme.
New safety concepts in mountain bike parks: a driving force for sustainable sports tourism

Summer tourism becomes more and more important in alpine regions due to relatively mild winters and a shift of the tourists interests towards action and fun. Thereby, mountain bike (MTB) parks offer a good possibility to use the existing winter infrastructure. However, there is no common experience about the general signposting of MTB trails, the loads experienced by the riders, the optimal constructions of jumps and the use of PPE. Therefore, the aims of this project are a) to collect data and information about the construction modes and signposting of MTB parks, the forces acting on riders and the necessary protection; b) to create a guideline to enhance safety, reduce injuries and optimize the sustainability. At the end of the project a demonstrative “safe” MTB jump/section according to the guideline will be built or adapted both in Nevegal and in Saalbach-Hinterglemm. The project goals will be realized within different WP including state of the art analyzes of bike parks, kinematic and dynamic data acquisition of riders during jumping and the development of a method for their evaluation, in addition to the analyzes of protection equipments. The final product of this project will be a guideline and a demonstrative section/jump enhancing the safety of riders and encourage a cross-border and a sustainable tourism.
Dopamine and bone metabolism in rheumatoid arthritis

Rheumatoid arthritis (RA) is associated with local bone erosion and systemic osteoporosis, which leads to severe disability and low quality of life. Although treatment with biologics can reduce bone loss by inhibiting inflammation, biologics are not able to achieve bone repair and some patients do not respond sufficiently to the treatment. Therefore, an efficient long-term therapeutic approach to target bone erosion and osteopenia still need to be established. Here, we describe a possible involvement of the neurotransmitter dopamine (DA) in bone metabolism and how we aim to use this new pathway to control bone erosion and restore bone mass in RA.

The involvement of DA on joint inflammation in RA was demonstrated in vitro and in vivo, and an elevated concentration of DA in the synovial fluid of RA patients was also described. Moreover, we recently described that DA is produced in RA synovial tissue and can act in an autocrine/paracrine manner. However, it is still unclear which role local DA can exert on bone erosion in RA. We performed preliminary experiments and could confirm the presence of DRs in RA bone remodeling zone and in osteoblasts isolated from RA. Moreover, DR activation stimulated IL-6. This confirms the active role of local DA also on bone metabolism in RA.

Goal of the present study is therefore to elucidate the mechanisms of action of DA in bone remodeling in RA, in order to find out how to modulate this pathway to control bone erosion and stimulate bone formation in RA. Specifically, we will address the following issues: 1) To identify the mechanisms responsible for DRs expression in RA bone remodeling zone, 2) To define mechanisms of action of DRs on bone metabolism in the context of RA 3) To prove the clinical applicability of DA modulation in arthritic joints towards an anti-inflammatory and bone-protective path. Final goal of this project is to establish a new therapeutic approach to block bone erosion and restore bone mass in RA.