SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
GOvernance, TOurism and NATURE

The programme area boasts a wide variety of natural (e.g. national parks, landscapes etc.) and cultural as well as historical attractions. Moreover, the project area includes less known places with interesting cultural and natural peculiarities for tourism attractiveness. From a cross-border perspective, initiatives for joint planning and management of tourism are rare, except for few remarkable cases (e.g. Alpine Pearls). The project area needs to develop a vision of the territory as a common economic asset to protect and enhance. Therefore, the project overall objective is to create a model for territorial development based on the sustainable use of less known tourism destinations, their natural and cultural heritage. _x000D_
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To achieve this, the project will: _x000D_
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1) Improve local tourism governance by involving citizens and economic actors in a common concept of tourist destination management. To this aim, a model for tourism governance will be produced. _x000D_
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2) Incorporate the principles of the “European Charter for Sustainable Tourism in Protected Areas” (ECST) into the design of innovative tourism products. To achieve this, the project will first develop a toolkit for sustainable tourism and then apply it to pilot actions. _x000D_
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3) Design a high-quality tourism offer integrating active, wellness, natural & cultural vacation with agro-food production, handcrafts, and folklore. The new products developed with same criteria will be promoted and marketed as one cross-border tourism network.
Certified packs for easier next-generation sequencing clinical diagnostics

Next-generation sequencing (NGS) has revolutionized genomic research by drastically decreasing the cost of sequencing and increasing the throughput of generated data, but still has not been able to reach its implementation in clinical diagnostic laboratories where there is a huge potential market application for it. The current market gold-standard in clinical diagnostic (i.e. Sanger-based sequencing) is outdated, much less efficient and more expensive than NGS, but no current market solutions have yet been able to properly address the complexity involved in transferring and validating gold-standard procedures to NGS platforms in clinical environment. In fact, current competing solutions are disruptive, complex, non-efficient and non-validated to address the challenges of transferring NGS to clinics. The easierNGS business concept aims to create and offer an innovative package of services and products which combined will allow a fast, cost-effective, streamlined and certified full sample-to-result solution to clinical laboratories that wish to seize the tremendous benefits of the new NGS era. Towards this objective, a feasibility assessment of the easierNGS business concept will be conducted to better determine its technical, economic and legal viability, as well as plan its most appropriate operational and scheduling strategy. Three case studies (i.e. NGS panels for pharmacogenomics, neonatal screening and infertility risk factors) will be used to generate a proof-of-concept of the easierNGS and help define the technical aspects and guidelines for future easierNGS packages and support a conscientious “Go/No go” decision towards a real market assessment.
What does it take to build an artificial virus?

Using rational design with DNA origami, we propose to create synthetic virus-like assemblies capable of accomplishing cell-invading and gene expression functionalities known so far only from natural viruses. We envision these assemblies to be useful for studying and testing viral import mechanisms, and also for gene delivery, enabling fundamental studies and potential medical applications. The objectives include selecting and invading a target cell type, systematically solving the challenges of endosomal escape and nuclear delivery, and inducing the expression of user-defined genetic information in the nucleus. To achieve these objectives, we will recreate and experimentally test mechanisms believed to be used by viruses, including receptor-mediated endocytosis, stimulus-dependent lipid membrane penetration, membrane fusion, active cytosolic transport, and nuclear import. We foresee building synthetic shells carrying genetic information stored in nucleic acids, which we refer to as the “gene shuttle”. The particles will optionally include a membrane envelope and user-defined surface features to mediate receptor-ligand interactions with cell membranes, and they will be capable of stimulus-dependent conformational changes to trigger membrane fusion or membrane penetration. They will shed structural elements on the path to the nucleus, similar to viruses. In addition to delivering genes for fluorescent markers, as a proof of concept demonstration we plan to use the gene shuttle to deliver the genetic information for expressing chimeric antigen receptors (CAR) in a T cell line, which promises to be of use in cancer immunotherapy. The project promises to yield a gene delivery system with capabilities beyond current synthetic vectors, which struggle to overcome the many cellular barriers to deliver and express genetic cargo. For safety reasons, the gene shuttle will by design be unable to assemble in the context of a cell to prevent uncontrolled autonomous replication.
Neo-Ottomanism? new strategies of turkey and the impact of foreign aid to post-war cultural reconstruction in the balkans

This project seeks to find out how foreign assistance in the fields of culture, religious revival and education change regions ravaged by inter-ethnic violence and state breakdown, and how such foreign assistance is perceived locally. My case study is the assistance provided from the Turkish Republic to Bosnia-Herzegovina, and local responses to it. The empirical research will focus on Turkish aid in the areas of higher education, religious studies, and the rebuilding of Ottoman-era monuments. This project sets the analysis of the impact of Turkish aid in the Balkans in the context of the revival of the concept and debates on Neo-Ottomanism in the region and globally. The analysis poses following questions: How do the interpretations of the historical legacy of the Ottoman Empire in the post-Yugoslav region correspond with actual policies of aid that the Republic of Turkey provides as a major donor, especially for post-war reconstruction projects in Bosnia-Herzegovina? What sort of changes in the political and popular culture in the beneficiary country can we observe as a result of Turkish aid in the areas of culture, higher education and religious education, according to local responses in Bosnia-Herzegovina? What is the interaction between the fears of Neo-Ottomanism as an alleged expansionist and ‘Islamization’ program of Turkey in the Balkans and the anti-Turkish, anti-Muslim discourses as a recent characteristic of the populist rhetoric in several European Union states?
Individual Differences in the Effects of Music Engagement on Responses to Painful Stimulation

<h2>Abstract</h2> Engaged attention, including music listening, has shown mixed results when used as a method for reducing pain. Applying the framework of constructivism, we extend the concept of engagement beyond attention/distraction to include all cognitive and emotional/motivational processes that may be recruited in order to construct an alternative experience to pain and thus reduce pain. Using a music-listening task varying in task demand, we collected stimulus-evoked potentials, pupil dilation, and skin conductance responses to noxious electrocutaneous stimulations as indicators of central and peripheral arousal, respectively. Trait anxiety (Spielberger State-Trait Anxiety Inventory) and absorption (Tellegen Absorption Scale) provided indicators of individual differences. One hundred and fifty-three healthy, normal volunteers participated in a test session in which they received 3 stimulus intensity levels while listening to background tones (No Task) or performing a music-listening task. Linear slopes indicating net engagement (change in stimulus arousal relative to task performance) decreased with increasing task demand and stimulus level for stimulus-evoked potentials. Slopes for pupil dilation response and skin conductance response varied with task demand, anxiety, and absorption, with the largest engagement effect occurring for high anxiety/high absorption participants. Music engagement reduces pain responses, but personality factors like anxiety and absorption modulate the magnitude of effect. <h3>Perspective</h3> Engaging in music listening can reduce responses to pain, depending on the person: people who are anxious and can become absorbed in activities easily may find music listening especially effective for relieving pain. Clinicians should consider patients' personality characteristics when recommending behavioral interventions like music listening for pain relief.
An Undergraduate Primer on Quality-Differentiated Demand

This article presents a student exercise on the logic underlying demand for quality-differentiated products. The argument builds and extends on basic constructs from undergraduate microeconomics, developing a linear demand structure to reflect consumer preferences for quality variation and a brief critique of market responses to those preferences that indicates potentially greater efficiency loses under monopoly once the possibility of quality distortions are accounted for. Various policy extensions are noted. These include applications in utility pricing tied to quality variations in service reliability, the potentially disproportionate impact on lower income households of quality distortions created by monopoly practices, and the potential of profligate resource use by monopolies which are shown to favor higher over lower quality products. Following along with the student exercise is a series of instructor notes with references to the scholarly literature and possible elaborations on various aspects of the exercise that instructors may chose to address. JEL Classifications: D4, D41, D42
Redesign of 26J Retarder Based on Its Defects

On account of the conditions of multiple faults of the easy damage of some parts of planetary reduction gear bearings,easy spring of planet carrier and planet gear pin during the use of 26J retarder made by Xibeibenniiu in the coal mines,bearings of the same size with different properties are adopted and optimized fixing methods of planet carrier and gear pin are used;the application of these proves to be effective,it guarantees the smooth operation and avoids the occurance of accidents,besides,it greatly reduces the labor intensity of the maintenance,demolition and replacement of the coal mine maintenance personals,improving working efficiency and ensuring the normal and safe production in the pits.
River transport 1189-1600

The purpose of this thesis is to establish the extent of river transportation in the period 1189 - 1600. Investigation is made as to which rivers were physically usable, which were legally usable and the comparative cost of land and river transport. The evidence of historic use is examined and these records are compared with the recent limits of use of the rivers. Hence an estimate is made as to which sections of rivers were probably used during that period.

The principles of fluvial geomorphology have been used to estimate past channel changes. The legal records have been studied and analysed. Considerable evidence of the use of rivers has been found which materially increases the lengths of rivers for which there are records of historic use.

It is concluded that:-

1. all rivers which were physically usable were legally usable,
2. there is a high probability that each section of a river which is now physically usable was usable by small boats in the period 1189-1600,
3. on the balance of probabilities each section of a river which is now physically usable was used during that period.

Finally the implication of this research for the present day law relating to public access on rivers is considered.
Flotation and free surface flow in a model for subglacial drainage. Part 2. Channel flow

Abstract We present a new model of subglacial drainage incorporating flow in a network of channels and a porous sheet, with water exchange between the two determined by pressure gradients. The sheet represents the average effect of many linked cavities, whilst the channels emerge from individual cavities that enlarge due to dissipation-induced melting. The model distinguishes cases when the water pressure drops to zero, in which case it allows for the drainage space to be only partially filled with water (free surface flow), and when the pressure reaches the ice overburden pressure, in which case it allows for uplift of the ice to whatever extent is needed to accommodate the water (flotation). Numerical solutions are found for a one-dimensional flow-line version of the model. The results capture typically observed or inferred features of subglacial drainage systems, including open channel flow at the ice margin, seasonal channel evolution, and high water pressures and uplift of the ice surface driven by rapid changes in water supply.
Long range-acting drivers of premetastatic niches in melanoma

Melanoma is the cancer with the fastest rising incidence world-wide, and although recent therapies can achieve unprecedented response rates, a significant fraction of patients still succumb to metastatic lesions. Key pending questions in the field are the mechanisms underlying the inherent metastatic behaviour or melanoma, whereby seemingly thin primary lesions (≥2 mm in depth) bear high risk of dissemination to proximal lymph nodes and ultimately, to distal sites.  A dynamic crosstalk has been proposed to be established between melanoma cells and the lymphatic vasculature at tumour-draining lymph nodes, favouring an immune-permissive “lymphovascular niche”. However, whether (and how) these lymphovascular interactions occur at distal sites is unclear. The Soengas group has generated unique “Lymphoreporter” melanoma mouse models for non-invasive and whole body imaging of tumour progression. These lymphoreporters demonstrated that primary melanomas induce neo-lymphangiogenesis at distal pre-metastatic sites, already from very early stages of the disease, before dissemination occurs. Proteomic analyses were then performed to identify factors in the melanoma secretome that could drive these long range-acting effects and subsequently filtered these proteins for novelty (i.e. no previous link to melanoma and lymphangiogenesis). Here I will focus on the top-ranking factors in this screening. In particular, I will define the impact of these newly-identified melanoma secreted factors on tumour progression and metastasis, focusing on key components of the lymphovascular niche (i.e. on the crosstalk of tumour- vasculature-immune system). Secondly, I will assess the impact of these genes as prognostic biomarkers and indicators of response to clinically-relevant treatments. These studies will be performed in collaboration with dermatologists, pathologists and oncologist to define the physiological relevance of our work.
Common Land for sustainable management

COMMONS project faces the challenge of territorial management in marginal lands in the framework of a continuous concentration of former rural population towards urban or peri-urban areas. Important natural areas risk environment depletion because of changing in the utilization patterns and abandoning of traditional practices. Some of these areas correspond to ancient common lands once managed for the livelihood of a whole village, but now subject to overgrowing. Generally common land is a natural area owned by one person, public or private, but over which another is entitled to excercise right of use in common with others, such as a local community. Common lands find their roots in ancient history, since Middle Age in Italy or the ancient Romanian state, Dacia, in 88 BC, in Romania.
Across centuries common lands were preserved by the managing system in use, and nowadays these areas cover habitats often of very high nature conservation value, because of their very long continuity of management. Commons were once widespread across Europe, there are still existing but  faces threats due to the complexity in defining the legal entity and rights of the commoners, and scarcely still represent an intersting source of income for communities.  Nevertheless the rights to use common lands  are exclusive and only people from the community can exploit the natural resources, but must as well take care of the area. This double sided aspect of common lands, being rich in nature and subject to special legal treatment, represent an opportunity which risks to be forget.
COMMONS intends to reasses the value of the uncoltivated common lands - called forest based common lands to distinguish from rural common lands – as a valid instrument for preserving natural resources and valorise natural products in order to both preserve the natural heritage and reduce the phenomenon of depopulation. In order to do so the partnership is composed mainly of PPs sharing the same situation, so that they can help each other in improving local policies, but as well of partners willing to witness an alternative although grounded in traditions.
Enhancement of the Concordia territory

The project aims at improving the road section between Sella Carnizza and Uccea, that it to say the road connecting the municipality of Resia with the State border, in order to ensure transit safety and smootherrunning traffic, as well as to foster mobility among cross-border workers and tourists. To this end, the road width will be increased (based to the morphology of the ground) - below the existing road - by means of retaining walls properly covered with stones and/or, above the road, by excavating and arranging the existing slopes, possibly resorting to minor containing work. The road layout will be modified by removing the most critical and winding points. To this end, some slopes will be excavated and subsidence areas will be filled also by means of small connecting bridges. The whole work will be finished with graded ramps, humps, asphalt surfacing, protective guard-rails and any additions that may be deemed necessary. All meteoric water drainage canals are going to be maintained or suitably restored to full efficiency in order to improve the ordinary water outflow. The overall intervention was planned while attaching special attention to its inclusion in the surrounding environment, to the covering of escarpments that are subject to soil movement and in general to avoid any action that might have a disruptive environmental impact.
Le Cercle et la Terre dans l’imaginaire des Amérindiens du Québec : topos ou utopie écologique ?

Cette étude vise à resituer en contexte des valeurs fondamentales de l'imaginaire amérindien, qu'on pourrait considérer comme utopiques si on les appréhende du point de vue eurocentrique.L'analyse de quelques oeuvres d'auteur(e)s amérindien(ne)s du Québec, d'après une approche écocritique fondant entièrement ses assises sur la pensée autochtone, permettra de restituer à ces thèmes et motifs le statut de topoï, au sens littéraire autant que géographique, et de déjouer par là le risque de les inscrire dans le domaine de l'utopie, donc de la négation et du non-lieu.
Mediterranean Tourism Network

The project MedTourNet aims at promoting the notion of sustainable tourism development of insular and coastal areas through: a) The development of new tourism products (eg. conference, educational, religious, cultural tourism, agrotourism); b) Reduction of the seasonality phenomenon thanks to the provision of new tourism products; c) The promotion of local traditional products; d) The use of new methods and tools for the promotion of traditional products and tourism products to the European and global market. Tourism industry in the regions involved is one of the most important growing economic sectors, and is exhibiting similar weaknesses but at the same time similar opportunities for future development. The partnership has active involvement in local and regional development and has identified common characteristics critical in the tourism sustainable development as follows: • Tourism in these areas has a seasonal demand pattern with impact to quality of services. National and private investment is needed in order to have significant magnitude of operation, retain experienced personnel, provide high quality service and amortize repair and upgrade capital expenditures over larger periods of time. However Tourism business is mostly small SMEs, unable to carry this long investment. • Tourism is not focused on niche markets that are profitable like conference, educational, therapeutic, sports and other thematic tourist areas. • There is no Tourism Local Resources Exploitation Plan that will take advantage of existing infrastructure and tourism resources (sightseeing, museums, theatres, festivals etc). In tourist areas there is no central organized tourism plan that can offer solutions and facilities (eg a daily excursion schedule for family entertainment, or one day visitors) that can be included in ‘tourism packages’. • Tourist enterprises are not centrally directed or controlled and thus planning of activities and synergies are left to private entrepreneurship with know-how spill over and synergies to be minimal. At the same time, the size of tourist enterprises is very small SMEs and the lack of networking, use of IT and Telecom technology, as well as lack of proper language and tourist services training makes the situation even more difficult. Med Tour Net objective is to support sustainable tourism development through the exploitation of existing tourism resources and the expansion of the tourism market which is a) tourism period and b) target tourism segment. During the MedTourNet project the partnership will take the necessary actions to describe the existing situation, infrastructure, tourism resources and existing services, and to define new tourism products that can be developed in the area according to existing resources
Polymer reinforced glass mat with enhanced nail shank shear resistance, shingles including the same, and methods of manufacturing the same

Some embodiments of the present disclosure relate to an article comprising a reinforced glass mat. In some embodiments, the reinforced glass mat includes a glass mat and a reinforcement material. In some embodiments, the glass mat includes a web of glass fibers. In some embodiments, the reinforcement material is embedded into the web of glass fibers of the glass mat. In some embodiments, the reinforced glass mat includes a sufficient amount of the reinforcement material, so as to result in a nail shank shear resistance of 13 lbs to 17 lbs, when the article is tested according to ASTM 1761 at 140° F. Methods of making the article, specific embodiments of the reinforcement material in the form of a polymeric binder, and methods of forming a roofing shingle from the article are also disclosed.