SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Substance abuse may be a risk factor for earlier onset of Huntington disease

Environmental factors may contribute as much as one-third of the variance in Huntington disease (HD) age of onset. Substance abuse is a risk factor for other neurodegenerative disorders; however, whether substance abuse influences HD age of onset is not well established. This study investigated the relationships between alcohol, drug, and tobacco abuse and HD age of onset in 136 participants with symptomatic HD. CAG repeat length was used as a covariate in all analyses, as it represents the most significant determinant of HD age of onset. The relationship between substance abuse, HD age of onset, and sex was also examined, as women may experience greater medical harm from substance abuse. Lifetime alcohol abuse and lifetime drug abuse were associated with earlier age of HD onset; a similar trend was seen for current tobacco abuse. For women, lifetime alcohol abuse was associated with earlier onset of HD, with a similar trend for lifetime drug abuse. However, alcohol, drug, and tobacco abuse were not significantly associated with age of onset in men. Further work is needed to determine whether substance abuse is a causative risk factor for earlier onset of HD, and why the environmental factors associated with age of onset vary by sex.
Orthoptic and video-oculographic analyses in oculopharyngeal muscular dystrophy

Mild ophthalmoparesis can be seen in oculopharyngeal muscular dystrophy (OPMD).Orthoptic analysis included assessment of phoria/tropia, eye excursion, saccades, pursuit, stereoacuity, and Hess-Lancaster screen test. Video-oculography included fixation, horizontal and vertical saccades, and pursuit.Orthoptic abnormalities were: tropia (4 of 6); abnormal eye excursion (4 of 6, 78% involved lateral or superior rectus muscles); abnormal horizontal or vertical saccades (2 of 6); abnormal pursuit (0 of 6); abnormal stereoacuity (2 of 6); and pathological Hess-Lancaster screen (4 of 6). Video-oculographic abnormalities were present for: fixation (1 of 6); saccade latency (1 of 6); horizontal pursuit (3 of 6); and vertical pursuit (0 of 6). For horizontal saccades, mean velocity, peak velocity, and gain were pathological in 5 of 6, 5 of 6 (61% of pathological mean and peak velocities involved abducting eye movements), and 3 of 6, respectively. For vertical saccades, mean velocity, peak velocity, and gain were pathological in 4 of 6, 4 of 6 (53% involved upward movements), and 3 of 6, respectively.The data indicate preferential involvement of lateral and (to a lesser degree) superior rectus muscles in OPMD.
EVALUASI PROSES BONGKAR MUAT AVTURDI MT. SRIKANDI

Abid Gani Subandi. (50134737 N), 2017 Evaluation of loading and unloading process
in MT. Srikandi Advisor Lecturer I: Dr. Capt. Suwiyadi, M.Pd., M.Mar.Dosen
Advisor II: Dwi Prasetyo, MM., M.Mar.
The background of the researcher chooses the title of the thesis Evaluation of
Avtur loading and unloading process in MT. Srikandi the researcher is
interested in handling both loading and unloading. From some voyage conducted MT.
Srikandi, researcher feel there is a need to be evaluated on the implementation of
loading and unloading because there are often disputes both from the ship and from the
land side due to lost (reduction of payload) and gain (additional charge). From the
background of the researchers formulate the problem. 1). Preparation what is done for
the process of loading and unloading avturdi MT. Srikandi.2). Is there a difference in
the number of aviation loads loaded and unloaded between ship figure and shore figure.
3). What things to do when there is a difference between being dismantled and loaded.
This thesis research is based on the principle of loading, understanding of tanker
ship cargo operation, Pertamina Material Safety Data Sheet (MSDS), and load
calculation for based on ASTM Table and dictionary of shipping terms.
Research methods that researchers use in writing this thesis is to use descriptive
quantitative methods and analysis of simple statistical data. Sources of data from this
study came from the observation of handling cargo on the MT. Srikandi during the
period of October 2015 until July 2016, then processed using Microsoft excel.
The results showed: 1) The implementation of dismantling done in MT. Srikandi
has not fulfilled the standards specified in MSDS Pertamina, 2) There is a difference of
charge (lost) in the calculation of R2 in 3 voyage in the sample by researcher with
percentage of lost voyage I 0.056%, voyage II 0.06% and voyage III 0.025% 3). Having
known the difference in landload and the ship's side observed what made the lost
happen, after seeing the return of the charter value of the land-based vessel made Letter
Of Protest as not satisfaction with the ship's consistency and the ship made the Statment
to apply teh satisfaction of Disperancy to defend the lost.
From result of research can be concluded that at every activity of loading or
unloading will always happened difference of charge. The researcher's suggestion for
officers and candidates of ship officers is to study and master the science of handling
the load, especially in the calculation of cargo. Because of the load calculation can
know the amount of cargo and prevention of emergency conditions on the ship and
achieved the safety of loading and unloading properly.
Keywords: Avtur, Evaluation, Loading, and Unloading
Analyses of spray break-up mechanisms using the integral form of the conservation equations

We present further uses of a theoretical framework based on the integral form of the conservation equations, to gain insight and predictive capabilities for the spray break-up regimes, turbulence effect on drop size, and secondary break-up processes. Quantitatively and qualitatively, the results indicate that the current analysis method can be useful in understanding and predicting various aspects of spray break-up processes. Correct Weber number boundaries for Rayleigh, wind-induced, and atomisation regimes are calculated using a Weber-Reynolds number relationship obtained from first principles. Good agreements with experimental data for turbulence and secondary break-up effects on the drop size are also achieved. It is projected that small modifications of the source terms within this framework can render possible analyses of other important processes, such as swirl sprays and air-blast atomisation.
Optilift - offshore lifting and logistics

The vision of the OptiLift project is to upscale, pilot and commercialise our unique toolset for improved safety, increased efficiency and more environmental friendly offshore lifting and logistics. We will enable annual cost savings of €14.m per offshore rig operator and reduce CO2 emissions with up to 50% compared to current platform supply vessels. We will aid solving the industrial and societal problem of safer and more efficient offshore lifting and logistics - provide a significant contribution to the instalment of Blue Energy as outlined in the Blue Growth Strategy of 2012.

The overall objective of the OptiLift Phase 2 project is to address and implement the findings of our SME Phase 1 Feasibility Study (GA#674094) to enable rapid and successful commercialisation of OptiLift. We have outlined a series of Commercialisation Objectives that can be grouped in 3 categories and achieving them will bring us to a wide international market uptake:

1) Technology maturation objectives will optimise OptiLift functionalities prior to piloting at end-user’s facilities. Objective is to raise the TRL of our technology from its current TRL6 to 8 (WP1).

2) Pilot and validation objectives to demonstrate and validate the commercial potential of OptiLift in actual end user operating environments covering both offshore and onshore lifting and logistics operations. The piloting activities will elevate OptiLift from TRL8 to 9 (WP2).

3) Market maturation, communication and innovation management objectives enabling us to successfully bring OptiLift to the
market and reach sales traction beyond Phase 2 (WP3-6).

Through OptiLift we will significantly boost our growth – quantified as accumulated revenues exceeding €56m for the 5-year post-project (2023) with accumulated operating profit of more than €33.6m and employment growth of at least 63 FTEs. Moreover, we expect to generate €1.31bn in reduced costs for our end-users and reduce CO2 emissions with 200,813 tonnes.
Bicyclists Injured by Automobiles: Relationship of Age to Injury Type and Severity—A National Trauma Databank Analysis

Bicycle riding is a popular recreational activity and a common mode of transportation. Impact with a motor vehicle, however, has the potential to result in significant injury to the rider. The magnitude of this problem, the incidence and types of injuries, and the effect of age on these variables are poorly defined in the literature.This was a National Trauma Databank study during a 5-year period. Injury Severity Score (ISS), specific injuries sustained by riders, and outcomes were analyzed according to age groups (≤ 14 years, 15-35 years, 36-55 years, 56-65 years, and >65 years).During the study period, there were 12,429 admissions as a result of bicycle-related injuries involving motor vehicles (0.7% of all trauma admissions). There were 4,095 patients (32.9%) ≤ 14 years, 3,806 (30.7%) 15 to 35 years, 3,413 (27.5%) 36 to 55 years, 688 (5.5%) 56 to 65 years, and 427 (3.4%) >65 years. The incidence of severe or critical trauma (ISS ≥ 16) in the five age strata was 20.3%, 19.2%, 26.4%, 33.4%, and 38.2%, respectively (p < 0.001). The most commonly encountered injuries consisted of extremity fractures (34.9%). Patients ≤ 14 years old were significantly more likely to suffer fractures to the lower extremity and less likely to sustain fractures to the upper extremity. The overall incidence of head injury was 28.3% and increased in a stepwise fashion with increasing age, ranging from 26.5% in the age stratum 15 to 35 years to 38.6% in the age stratum >65 years, p < 0.001. The overall mortality was 3.7% and ranged from 2.4% in the age stratum ≤ 14 years, to 12.2% in the stratum >65 years. After adjusting for differences in age groups, there was a stepwise increase in the risk of death for bicyclists >65 years old who were 10-fold more likely to die than those ≤ 14 years old (adj. p < 0.001).Bicycle-related injuries involving motor vehicles are associated with a high incidence of head injuries and extremity fractures. Age plays a critical role in the severity and anatomic distribution of injuries sustained, with a stepwise increase in mortality with increasing age. Further evaluation of specific preventative measures, especially for elderly bicyclists is warranted.
Towards a postgrowth economics: a viable postgrowth economy without increasing inequality

Economic growth seems unlikely to continue at current rates, if at all. But we currently do not have a plan of how to manage a postgrowth economy. This represents a major impediment to formulating policies for how the EU may best pursue its objectives for development, environmental protection, and the elimination of poverty in a future postgrowth economy. There is debate over whether our current economic system based on interest-bearing debt can be made viable postgrowth, and evidence that even slowing growth leads to increasing inequality. Here, I propose research to integrate existing theoretical research into postgrowth viability with research into measures to prevent inequality from increasing. Since no industrial economy has yet experienced prolonged periods of very slow or negative growth, I will test the predictions against historical case studies. The project will achieve four objectives: to identify the parameters in which a postgrowth economy is viable; to identify the parameters in which continually increasing inequality is also avoided; to test these parameters against historical case studies; and to draw on these results to evaluate policies for producing a postgrowth economy that is both viable and avoids inexorably increasing inequality.  

The fellowship will allow me to broaden and deepen my knowledge of ecological economic approaches to postgrowth whilst bringing my knowledge of property economics, comparative institutions, and historical postgrowth to my hosts at ICTA. We will disseminate the results to academics and policy makers, with the historical aspect making quite technical debates much more accessible for communication to a wider public.

The fellowship will place me, and ICTA, at the forefront of the emerging field of theoretical and historical postgrowth research. I have developed a realistic implementation plan together with my hosts at ICTA, a world-leading centre for research into postgrowth.
Jpiamr- antimicrobial transmission interventions

In the past 90 years since their discovery, antibiotics have saved millions of lives from bacterial diseases. However, emerging resistance to antimicrobials now threatens many advances achieved in modern medicine. AMR is a critical global health issue tightly linked with the One Health concept, which recognises that human and animal health are inextricably linked, and that diseases are transmitted from humans to animals and vice versa. One Health also encompasses the environment as another link between humans and animals and a potential source and reservoir of AMR. Antimicrobial resistance is a growing global health concern and threatens the future treatment and health of humans and animals. In addition, AMR limits our ability to achieve several of the UN Sustainable Development Goals (SDGs). The global challenge to address AMR goes beyond the production of new antibiotics and therapies. Reducing demand for new antibiotics through public awareness, infection prevention and control, prudent and rational use of antibiotics for humans and animals, as well as effective diagnosis and surveillance of antibiotic-resistant infections and monitoring antibiotic use, are crucial when dealing with this problem globally. The transmission and spread of AMR in and between One Health compartments is complex, which emphasises the need for comprehensive interventions to reverse the trend of increasing human and animal infections resistant to treatment. The ERA-NET Cofund JPIAMR-ACTION will tackle this central challenge by supporting research and innovation for the development and testing of strategies and methodologies to reduce the transmission and spread of AMR within a full One Health spectrum. The JPIAMR-ACTION co-funded call and other activities will be instrumental in producing new innovative approaches, and advancing existing actions towards the development of new and improved interventions to inhibit or limit the development of AMR in humans, animals and the environment.
Improving policies to boost SME competitiveness and extraversion in EU coastal and rural areas where aquaculture is a driver of the regional economy

IMPROVING SMEs COMPETITIVENESS IN REGIONS WITH AN AQUACULTURE BUSINESS ECOSYSTEM:_x000D_
More than 90% of businesses in EXTRA-SMEs regions are inland and coastal SMEs operating across and around the aquaculture value chain, contributing to growth and creation of jobs. Along the chain, these economic operators are characterized by systematic weaknesses in reaching international markets and exporting their products. To this end, EXTRA-SMEs will support public authorities to join forces and exchange experiences in a) administrative simplification, b) expansion in new markets, c) innovative value-added product solutions, d) personnel up skilling, and e) resolution of stakeholders’ conflicts of interests. _x000D_
_x000D_
OBJECTIVE:_x000D_
EXTRA-SMEs brings together 8 regions from 7 countries, to achieve expansion of rural and coastal SMEs in wider markets for the promotion of their products, through simpler and improved administrative processes, and innovative technologies. _x000D_
_x000D_
EXPECTED IMPACT:_x000D_
- Increased capacity of 200 staff of public administrations to effectively support SME competitiveness ._x000D_
- 14 million euros unlocked to support projects on the modernisation of the wider network of aquaculture SMEs._x000D_
- Increased awareness and consensus building among the wider aquaculture sector, the workforce, and citizens, to support measures for SMEs internationalisation operating locally (over 1000 individuals)._x000D_
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MAIN OUTPUTS & BENEFICIARIES:_x000D_
- 8 action plans to improve the addressed policy instruments, benefiting managing authorities and beneficiaries._x000D_
- 4 interregional workshops, 2 site visits and 1 EU-wide policy learning symposium to promote capacity building among partners and stakeholders._x000D_
- 13 policy briefs to transfer lessons learnt to EU public authorities._x000D_
- 1 benchmarking online toolkit for the assessment of the extraversion performance of SMEs._x000D_
- 4 joint thematic studies and analyses reports on territorial needs and pathways for the improvement of SMEs internationalisation.
All Political Participation Is Socially Networked?

This research examined the influence of attention to specific forms of traditional and online media on young adults’ online and offline political participation as well as voter turnout during the fall 2012 presidential campaign. A three-wave panel survey demonstrated that attention to traditional media did not increase offline and online political participation in September; instead, participation was heightened by attention to online sources, particularly presidential candidate websites, Facebook, Twitter, and blogs. In the following months, individual-level change in participation was attributable to attention to several online media sources as well as change in media attention. In the case of voter turnout, results suggest that television attention was positively linked to voter likelihood in September but was negatively linked to individual-level change in voter turnout in November.
Understanding driver planning behaviour when overtaking a bicyclist: Time to collision estimations from naturalistic driving data

In Europe, bicyclist road fatalities have increased for the last ten years. Active safety systems such as Automated Emergency Braking can give a considerable benefit in reducing bicyclist road fatalities, but knowledge on when they should intervene is still limited. Estimation of Time to Collision (TTC) when the driver starts planning to overtake (planning point) could help in improving active safety systems, since TTC is a good estimate of the available mitigation time for the algorithms to intervene. This thesis, carried out using naturalistic driving data from the UDRIVE project, mainly consisted in extracting data from bicyclist overtaking scenarios on rural road and modelling TTC and longitudinal distance to quantify how they are influenced by different factors. The result of the estimation is that the presence of oncoming traffic and an increase in bicyclist lateral distance caused a decrease of both TTC and longitudinal distance at the planning point. Moreover, male drivers showed higher TTC at the planning point than female drivers. Interestingly, the planning point was not affected by the overtaking strategy.
Ethylene-regulated (methylsulfanyl)alkanoate ester biosynthesis is likely to be modulated by precursor availability in Actinidia chinensis genotypes

The limiting steps of ethylene-dependent (methylsulfanyl)alkanoate ester biosynthesis have been investigated in this study, using closely related Actinidia chinensis genotypes and the commercial cultivar 'Hort16A'. Quantification of methylsulfanyl-compounds from the headspace of ethylene-producing kiwifruits revealed little variation in their volatile composition but remarkable differences in the magnitude of the fruit volatile levels. To test whether the variations in fruit volatile levels can be correlated with the genotype-specific apparent catalytic efficiency, the initial slope of the substrate response curve (V'(Max)K(M)(-1) where V'(Max) is the apparent V(Max) in a crude extract) was evaluated for total alcohol acyltransferase (EC 2.3.1.84) activity. The V'(Max)K(M)(-1) values of different (methylsulfanyl)alkyl-CoAs were in a similar range for most genotypes, which suggests substrate availability as the limiting factor for (methylsulfanyl)alkanoate ester synthesis in these kiwifruit. Furthermore, gene expression analysis of acyltransferase expressed sequence tags points towards the action of multiple isozymes for (methylsulfanyl)alkanoate ester synthesis, emphasizing the central role of substrate levels on final ester concentrations. Volatile levels of the potential precursor methional were increased in ethylene-producing A. chinensis kiwifruit and a close connection between (methylsulfanyl)alkanoate ester formation and ethylene synthesis in plants is proposed. Finally, a possible biosynthetic pathway is presented.
SAFETY AND TRACKING SYSTEM AND METHOD FOR PILGRIMS

The invention relates to a system in the form of an armband allowing the family of a pilgrim to remotely track the pilgrim. The system is equipped with GPS, GSM, an accelerometer, an LDR, and a microcontroller. Said microcontroller implements a method for capturing data relating to the pilgrim and sending said data to a central server which processes the data and renders it accessible via a web interface in a secure manner to the members of the pilgrim's family. The armband can also be equipped with special sensors according to the state of health of the pilgrim, such as a pulse sensor or a blood glucose level sensor.
Optimization of wheat sprouting for production of selenium enriched kernels using response surface methodology and desirability function

Response surface methodology and desirability function were used as tools to optimize wheat (Triticum aestivum L) germination conditions in the presence of SeO3Na2 to obtain selenium (Se)-enriched kernels. The effects of Se concentration (32.85–54.76 mg SeO3Na2/L), germination time (24–48 h) and germination temperature (18–25 °C) were investigated. The best Se-enriched wheats were selected based on selenomethionine (SeM) content, α-amylase activity (AC), and sprouting features such as kernel moisture (KM) content, germinated grains (GG) and radicle growth (RG). A second order polynomial model produced a satisfactory fitting of the experimental data considering the total kernel SeM content (R2adj = 58.8, S = 14.29), AC (R2adj = 59.80, S = 48.78), KM (R2adj = 71.30, S = 2.94), GG (R2adj = 66.70, S2 = 1.20) and RG (R2adj = 84.60, S = 23.38). Total desirability (δ) value was 67.6% in operational conditions (35 mg Se/L, 25 °C and 24 h germination). Under these conditions sprouted kernels contained 41.8 g/100 g, 95.5% and 98% for KM, GG and RG respectively, and 54 mg Se/kg as SeM and 54.8 CU of AC. In conclusion, the generated models with desirability methodology could be useful to optimize SeM content and alpha amylase activity in Se-enriched sprouted wheat kernels.
Behavioral and Molecular Biomarkers in Translational Animal Models for Neuropsychiatric Disorders

Modeling neuropsychiatric disorders in animals poses a significant challenge due to the subjective nature of diverse often overlapping symptoms, lack of objective biomarkers and diagnostics, and the rudimentary understanding of the pathophysiology. Successful translational research requires animal models that can inform about disease mechanisms and therapeutic targets. Here, we review behavioral and neurobiological findings from selected animal models, based on presumed etiology and risk factors, for schizophrenia, bipolar disorder, and major depressive disorder. We focus on the use of appropriate statistical tools and newly developed Research Domain Criteria (RDoC) to link biomarkers from animal models with the human disease. We argue that this approach will lead to development of only the most robust animal models for specific psychiatric disorders and may ultimately lead to better understanding of the pathophysiology and identification of novel biomarkers and therapeutic targets.