SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
The impact of tfiid on the transcription initiation machinery – a structural perspective.

Transcription is a first step of gene expression, a process by which a functional gene product is synthesized based on genetic information from DNA. Gene expression is tightly regulated with complex mechanisms that give cells the flexibility to adapt to a variable environment. Defects in regulation and transcription mechanisms leads to serious pathologies in cells and organisms, that in humans includes cancer development, autoimmunity and neurological disorders, cardiovascular diseases etc. 
Structural studies of transcription in the last two decades, brought priceless insight into the mechanisms involved in the process, especially concerning transcription initiation. The next step in understanding gene expression is to combine knowledge about gene regulation with the mechanisms of transcription initiation. I will investigate the molecular basis of gene regulation and transcription initiation interplay using strategy that combine state-of-the-art cryo-electron microscopy, chemical cross-linking, mass-spectrometry and biochemical assays.
Acute effects of non-weathered and weathered crude oil and dispersant associated with the Deepwater Horizon incident on the development of marine bivalve and echinoderm larvae

Acute toxicity tests (48-96-h duration) were conducted with larvae of 2 echinoderm species (Strongylocentrotus purpuratus and Dendraster excentricus) and 4 bivalve mollusk species (Crassostrea virginica, Crassostrea gigas, Mytilus galloprovincialis, and Mercenaria mercenaria). Developing larvae were exposed to water-accommodated fractions (WAFs) and chemically enhanced water-accommodated fractions (CEWAFs) of fresh and weathered oils collected from the Gulf of Mexico during the Deepwater Horizon incident. The WAFs (oils alone), CEWAFs (oils plus Corexit 9500A dispersant), and WAFs of Corexit alone were prepared using low-energy mixing. The WAFs of weathered oils had no effect on survival and development of echinoderm and bivalve larvae, whereas WAFs of fresh oils showed adverse effects on larval development. Similar toxicities were observed for weathered oil CEWAFs and WAFs prepared with Corexit alone for oyster (C. gigas and C. virginica) larvae, which were the most sensitive of the tested invertebrate species to Corexit. Mean 10% effective concentration values for total polycyclic aromatic hydrocarbons and dipropylene glycol n-butyl ether (a marker for Corexit) in the present study were higher than all concentrations reported in nearshore field samples collected during and after the Deepwater Horizon incident. The results suggest that water-soluble fractions of weathered oils and Corexit dispersant associated with the Deepwater Horizon incident had limited, if any, acute impacts on nearshore larvae of eastern oysters and clams, as well as other organisms with similar sensitivities to those of test species in the present study; however, exposure to sediments and long-term effects were not evaluated. Environ Toxicol Chem 2016;35:2016-2028. © 2016 SETAC.
Advanced robotic technology for handling soft materials in manufacturing sectors

SOFTMANBOT is an industrial-end-user driven project that will provide an innovative and holistic robotic system for the handling of flexible and deformable materials within labour-intensive production processes. The robotic system will be composed by three main pillars including a generic robotic perception system (perception of the product and the human operator), a multi-sensor control and planning platform (advanced control algorithms for shape and contact servoing, AI based task generalization) and smart dexterous grippers (smart mechanical design which will embody grasping/manipulation skills and integrate sensors – mainly tactile – for identifying precisely the contact state between the product and the gripper) able to handle soft components with high-levels of robustness and flexibility. The automation solution is aimed to work in close collaboration with human operators in order to help them in the execution of contact-based challenging tasks so that the productivity and job quality will be boosted which will highly contribute to bring back production to Europe. Special attention will be paid to the integration of novel robotic concepts based on aspects of safety, ergonomics, adaptability, acceptance and user experience. In order to facilitate the assessment of the performance, transferability, scalability and large scale deployment of these solutions, the demonstrations will be conducted under real industrially relevant environments in four pilot demonstrators involving four key manufacturing sectors – toy, textile, footwear and tyre –. The project is not just aiming at quantitative improvements brought by cutting-edge technologies in a specific sector, but to use technology innovation to support a change of paradigm where handling of soft materials with the involvement of robots become a feasible and widespread alternative for European factories, specially SMEs.
Applying GIS and Spatial Analysis to Studies of Health in Children with Disabilities

Abstract People with developmental disabilities live in a geographic context that influences their quality of life. Geographic Information Systems (GIS) can be used to qualitatively and quantitatively analyze such a context. At an individual and community level, GIS can be used to create a plan of action that ameliorates the life of people with disabilities. A brief introduction to GIS is followed by a review of studies that incorporated GIS to determine the challenges that people with disabilities undertake to access health services, recreational facilities, and grocery stores. Lack of public transportation, poverty, neighborhood crimes, and scarcity of doctors trained to interact with these individuals make life difficult for persons with disabilities and their caregivers. The second part of this chapter reviews studies that link the effect of pollution to the rate of developmental disorders. For example, increased rates of autism have been linked to toxic release and location of industrial facilities and National Priority List superfunds. In a similar way, preliminary results show that air pollution from road traffic influences mortality rate of infants with Down syndrome. GIS can be easily incorporated in epidemiologic studies, providing an out-of-the-box perspective that aids to address limitations and hazards in the lives of individuals with developmental disabilities.
Diagnóstico sobre rumorología en relación a las personas migrantes y la diversidad cultural en San Cristóbal de La Laguna (2021)

cualquier procedimiento, siempre y cuando se cite su autoría.Estrategia para prevenir el racismo y la xenofobia en el municipio de San Cristóbal de La Laguna Marco conceptualEl Proyecto Antirumores La Laguna se desarrolla teniendo en cuenta al conjunto de la comunidad lagunera y, por este motivo, no centra su investigación únicamente con las personas que se muestran claramente racistas, xenófobas o que albergan discursos de odio, sino con la ciudadanía general, los recursos técnicos y las personas con representación institucional, donde en muchas ocasiones se pueden difundir rumores de manera inconsciente y asociado a las personas migrantes, entendiendo los rumores como un punto de partida para alimentar discursos racistas y xenófobos.Para poder tener una visión más amplia, se considera imprescindible en esta investigación profundizar en el entendimiento de conceptos como son los estereotipos, los prejuicios y la discriminación y, cómo estos, se relacionan con los rumores.Con este objetivo, se ha consultado el Manual Antirumores (Consejo de Europa, 2018)Según la definición de Allport y Postman (1947), un rumor es una proposición específica de una creencia, que suele transmitirse entre personas por el boca a boca, sin que exista una evidencia fiable, pero que, sin embargo, es recibido como cierto.Se difunden de una persona a otra sin que se demuestre su veracidad, es decir, tienen credibilidad no porque existan pruebas directas que los sostengan, sino porque hay muchas personas que los creen.Estos autores asimismo identificaron los dos factores principales que determinan la intensidad de un rumor.Por un lado, la importancia del hecho; y por otro, la ambigüedad del mismo.Un rumor se propaga cuando el hecho tiene importancia en la vida de las personas y cuando la información resulta incompleta o ambigua.Ni la ambigüedad, ni la importancia por sí solas, pueden sostener un rumor.Por lo que, el alcance, la duración y la intensidad del rumor, serán equivalentes a
ARTIFICIAL PROTEINS AND COMPOSITIONS AND METHODS THEREOF

De novo artificial protein based reporters that may be expressed in eukaryotic (e.g., mammalian) cells and methods of using the same are provided herein.
Impact of the economic crisis on the health of older persons in Spain: research clues based on an analysis of mortality. SESPAS report 2014

Older adults are seldom considered in studies on the health impact of economic recessions or crises. However, they constitute a population group that is highly vulnerable to decreases in investment in health and social services and social security. Our aim is to examine the relationship between the economic crisis starting in 2008 and the health status of older adults in Spain. More specifically, we analyze changes in trends of mortality in relation to the crisis, the specific impact of winter on mortality and gender differences in the crisis' impact on mortality. Using data from the National Institute of Statistics of Spain on people over 60 years of age, the number of monthly deaths by age and sex from January 2005 to December 2012 was analyzed. Interrupted time series analyses and the "difference in differences" method were used. During the crisis, for adults 60 years and older: 1) the observed mortality seems to be decreasing at a slower rate than what would have been expected in the absence of the crisis; 2) there has been an increase in winter mortality; 3) the impact of the crisis has been greater for female than for male mortality. These results suggest sizable effects of the economic crisis on the mortality of older adults and argue for research done using more detailed analyses integrating economic indicators.
SUPPORT SYSTEM COMPRISING A BALLISTIC BODY ARMOR

The invention relates to a support system comprising a ballistic body armor (1) having a front and a back part (2, 3) and means (4, 5) for securing to the upper body of a human. Said support system also comprises a waist belt (8) on which at least one lateral support (9) is arranged. Said ballistic body armor (1) comprises a coupling (22) enabling a support device (14) to be detachably fixed to the rear side of the back part (3) of the ballistic body armor (1). Said at least one lateral support (9) provided on the waist belt (8) can be fixed to the support device (14).
Tendências de mortalidade por câncer de boca e orofaringe em idosos no Município do Rio de Janeiro, Brasil, 2010-2018

Objetivos: Estimar as tendências temporais da mortalidade por câncer de boca e orofaringe na população idosa, segundo sexo, no município do Rio de Janeiro-RJ, ao longo de três períodos, que totalizam 9 anos (2010-2018). Métodos: Estudo descritivo da mortalidade por câncer de boca e de orofaringe. Os dados correspondentes a cada CID foram coletados do Atlas On-line da Mortalidade do INCA. Resultados: Os homens de 60 a 69 anos, e de 70 a 79 anos acumularam maior incidência de óbitos por câncer de boca que as mulheres, e todas as faixas etárias masculinas obtiveram taxas de mortalidade maiores que as das mulheres, para todos os triênios, com relação ao câncer de orofaringe. Conclusão: Fatores etiológicos, como alcoolismo e tabagismo, podem ser fatores de risco ao câncer de boca; e por sua vez, o HPV é um fator de risco para o câncer de orofaringe.
Control and data flow compatibility in the interaction between dynamic business processes

In the coming years, one of the challenges for business processes is to obtain a high degree of flexibility and ability to adapt to the changing contexts. Two key elements for achieving this are the use of Semantic Web technologies and the possibility of decoupling the business and the interaction aspects in a business process. Nevertheless, these solutions open up new challenges related to the necessity of checking whether a set of processes can successfully cooperate. Compatibility questions should be considered from a control flow point of view (the order of the interactions should be appropriate) and also from a data flow point of view (the information exchanged should be—semantically—adequate). In this paper, we concentrate on the compatibility of a set of processes executed in DENEB, a platform for the Development and ExecutioN of wEB processes based on the Net-within-Nets formalism and that follows a conversational approach. More specifically, this paper examines whether a set of interactions among a set of processes is compatible and also whether a given (imposed) interaction logic is compatible with a given business logic. Processes and their interactions have been semantically enhanced by means of domain ontologies and compatibility questions are studied using standard Petri net analysis techniques. Copyright © 2010 John Wiley & Sons, Ltd.
Analysis of the biodegradability of the material

In order to reduce the environmental impact of products and offer a more environmentally friendly range of products, this project will analyse the different characteristics of the fibre in order to find new ways to accelerate and facilitate the decomposition process.
CHRISTMAS TREE ASSEMBLY WITH HIGH INTEGRITY PIPELINE PROTECTION SYSTEM

A mineral extraction system that includes a christmas tree. The christmas tree includes a valve that controls the flow of hydrocarbons through the christmas tree. A subsea control module couples to the christmas tree. The subsea control module controls the valve to control the flow of hydrocarbons through a conduit in the christmas tree. A high integrity pipeline protection system integrated with the subsea control module. The high integrity pipeline protection system includes a first pressure sensor that emits a first signal indicative of pressure in the conduit. A high integrity pipeline protection controller that receives the first signal indicative of the pressure and automatically controls operation of the valve in response to the pressure exceeding a threshold pressure.
Empowerment of marginalized convicted women through social enterprises

The European Union recently recognized “The empowerment of marginalized individuals” as one of the most relevant topics in modern societies. In its formal EU 2020 Strategy documents, the European Union listed “poverty, social exclusion and marginalization” as one of its main “Targets” and “inclusive growth” as one of its major “Priorities”. In 2011, the EU Commission adopted the Social Business Initiative (SBI), with the aim to promote the social enterprise as one of the most promising forms of entrepreneurial venture capable of dealing with this societal issue and fostering “inclusive growth”. However, the mechanisms by which the social enterprise may successfully allow the empowerment of marginalized individuals by economic driven solutions are not clear yet, and there is a lack of empirical works able to provide fine- grained/ micro-level evidences on this topic. Given these premises, I will commit this MSCA-IF research project to exploring the empowerment of convicted women, one of the most extremely marginalized category of individuals, using the perspective of social enterprise. I believe that a micro-level study of a successful case of social enterprises could reveal the critical factors behind the success or failure of these important initiatives, and from there, how they should be implemented.
I will finally address two main research objectives:
1) to investigate the micro-processes enacted by social enterprises, which successfully allow the empowerment of one of the most marginalized category of people: convicted women;
2) to compare the micro-processes enacted by social enterprises, which, in extreme cases of marginalization, allow them a) to bridge closed context of marginalization and the external environment, and b) to bridge the social and economic dimension.
Critical aspects of the project are: 1) its multidisciplinary nature and 2) the gender (women empowerment) related topic 3) extreme level of marginalization of convicted women.
A reinforcement learning approach to convoy scheduling on a contested transportation network

Ambushes, in the form of improvised explosive devices (IEDs), have posed grave risk to targeted vehicles operating on supply routes in recent theaters of war. In fact, history shows that this is an enduring problem that US military forces will likely face again in the future. This paper introduces a fundamental reinforcement learning (RL) model for determining convoy schedules and route clearance assignments in light of attack costs on a transportation network subject to IED ambushes. The model represents opponent interaction by assuming dependence between attack probabilities and targeted traffic patterns. There are currently few analytical approaches for this problem in the literature, but RL algorithms offer opportunities for meaningful improvements by optimizing individual movements across an extended planning horizon, accounting for downstream attacker-defender interaction. To our knowledge this approach has not been pursued elsewhere; therefore, this paper introduces the RL methodology with a fundamental formulation and initial computational results which show meaningful performance improvements over a one-step, myopic decision rules.
Physical architecture optimization system

The aim of the project PHAROS is the development, implementation and demonstration of a fully instrumented, automated and simulation-enabled engineering software platform capable to  automate the whole manual model-based systems engineering (MBSE) design process for physical systems architecture generation and optimisation, under special consideration of (but not limited to) automated optimal packaging, piping and routing generation of an aircraft wing section assembly which complies to a given set of engineering constraints. 

In order to achieve this, graph-based design languages in UML (Unified Modeling Language) are used to develop an automated, algorithmic implementation of interoperable engineering services for packaging, piping and routing. Design languages are executable in the software platform Design Compiler 43 of one industrial project partner and may be coupled for optimization purposes with the optimizer software Optimus of the other industrial partner.

Graph-based design languages are inspired by human languages, in which the vocabulary and rules form a grammar. The term 'design language' means that every sentence allowed by the grammar is a valid expression of a design. The term 'graph-based' means that each node in a graph is used to represent a requirement, a function, a solution principle, a component or any other arbitrary engineering expression one may encounter in the product life-cycle. This graphical representation of the design product and design process in form of a graph-based language is translated by a compiler into the disciplinary models of packaging, piping and routing in order to draw conclusions for the further optimization of the designs.

The automation of model-based systems engineering (MBSE) with a machine-executable V-Model will push the competitiveness of European aerospace companies to a new level of efficiency and will permit a unique selling proposition of innovation and cost leadership enabled by automation.
Mining the City Data: Making Sense of Cities with Self-Organizing Maps

Cities are instances of complex structures. They present several conflicting dynamics, emergence of unexpected patterns of mobility and behavior, as well as some degree of adaptation. To make sense of several aspects of cities, such as traffic flow, mobility, social welfare, social exclusion, and commodities, data mining may be an appropriate technique. Here, we analyze 72 neighborhoods in Mexico City in terms of economic, demographic, mobility, air quality and several other variables in years 2000 and in 2010. The visual information obtained by self-organizing map shows interesting and previously unseen patterns. For city planners, it is important to know how neighborhoods are distributed accordingly to demographic and economic variables. Also, it is important to observe how neighbors geographically close are distributed in terms of the mentioned variables. Self-organizing maps are a tool suitable for planners to seek for those correlations, as we show in our results.
Gun Charge Recognizing Simulation Based on Maximal Recoil Acceleration

To recognize gun charge using the maximal recoil acceleration,the recoil acceleration calculation model was built up based on the interior ballistic trajectory model and the recoil system model.Through simulation,the effect on the maximal recoil acceleration of the gun structural parameters and firing parameters which change in the actual operation condition was analyzed and the fact was found that the gun charge can not be effectively recognized only using the maximal recoil acceleration for the chamber enlargement and the powder temperature have remarkable effect on the acceleration.So the plan using the maximal recoil acceleration and the powder temperature to recognize gun charge was adopted which considering the four phases of the chamber enlargement at the same time.The recognizing model was set up using the artificial neural network and the simulation test indicates that the recognizing model has 100%correct recognizing rate to the gun charges.
Solitary waves in boundary layer induced by a travelling wave with increasing amplitude

Abstract The stability of solitary waves in an incompressible boundary layer, induced by a driving wave on the wall, is studied in order to investigate the generation and development of solitary waves. The nonlinear waves in the boundary layers, excited by a travelling wave with an increasing amplitude, rather than a standing wave, are described by forced Benjamin–Ono equation. In the study, pseudo-spectral method is used to approach to the solution of the governing equation. The results show that there are several wave energy wave branches and energy jumps to higher branch via violent oscillation. The wave pattern remains similar at every branch but the number of spike increases by one with every wave oscillation. In order to study the stability of the nonlinear waves, the perturbed wave equation is derived and a complex oscillator system is obtained from the linear perturbed wave equation. The stability analysis shows that the original wave loses its stability and wave energy begins to oscillate, and a new spike-like wave is born, when imaginary part of eigenvalue reaches to zero. Indeed, spile-like solitary waves can be induced by a travelling wave during the wave energy oscillations in boundary layers.