SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
A EFETIVIDADE DAS RESERVAS EXTRATIVISTAS NO ESTADO DO ACRE

As Reservas Extrativistas são uma categoria de Unidade de Conservação e se apresentam como importante ferramenta na conservação dos recursos ambientais, sociais e econômicos. Apesar do avanço legislativo, que culminou na criação do Sistema Nacional de Unidades de Conservação, no ano de 2000, e do novo modelo de gestão que foi adotado junto as Reservas Extrativistas no Estado do Acre, pouco se avançou na efetividade da gestão e na conservação do meio ambiente. Este estudo objetiva a análise da efetividade da gestão ambiental das Reservas Extrativistas no Estado do Acre, no período compreendido entre os anos de 1990 a 2018, com intuito de identificar se o novo modelo de gestão instituído pela Sistema Nacional de Unidades de Conservação (SNUC), tem contribuído para uma gestão efetiva, no que se refere a gestão, preservação ambiental e a economia. Constatou-se que as Reservas Extrativistas no Estado do Acre têm uma contribuição histórica e ambiental, porém pouco efetiva no que tange à gestão.
An integrated iterative learning control strategy with model identification and dynamic R-parameter for batch processes

Abstract An integrated iterative learning control strategy with model identification and dynamic R-parameter is proposed in this paper. It systematically integrates discrete-time (batch-axis) information and continuous-time (time-axis) information into one uniform frame, namely the iterative learning controller in the domain of batch-axis, while a PID controller (PIDC) in the domain of time-axis. As a result, the operation policy of batch process can be regulated during one batch, which leads to superior tracking performance and better robustness against disturbance and uncertainty. Moreover, the technologies of model identification and dynamic R-parameter are employed to make zero-error tracking possible. Next, the convergence and tracking performance of the proposed learning control system are firstly given rigorous description and proof. Lastly, the effectiveness of the proposed method is verified by examples.
TENDÊNCIA TEMPORAL DE MORTALIDADE POR DIABETES MELLITUS NO ESTADO DE SERGIPE E SUAS REGIÕES DE SAÚDE NO PERÍODO DE 11 ANOS

RESUMO: A incidência e as taxas de mortalidade por Diabetes Mellitus (DM) têm apresentado crescimento progressivo, no mundo. Objetivou-se avaliar a tendência de mortalidade por DM no estado de Sergipe e nas suas regiões de saúde, entre os anos de 2008 e 2018. Trata-se de um estudo ecológico, descritivo e de série temporal, com dados secundários notificados de óbito por DM, obtidos por meio da base de dados Sistema de Informações de Mortalidade, disponibilizado pelo Departamento de Informática do Sistema Único de Saúde. A análise temporal foi realizada com aplicação do modelo de regressão por pontos de inﬂexão Joinpoint Regression Analysis. Os óbitos por DM em Sergipe foram altos, prevalecendo no sexo feminino, com idade superior a 60 anos, cor parda e negra e com escolaridade até 3 anos. Na análise temporal, no período de 11 anos, em Sergipe a taxa média de mortalidade foi de 1,4% ao ano. Nas regiões de saúde, em Aracaju a taxa foi de 3,1% e em Estância de 2,6% ao ano, com crescimento progressivo significativo (p&lt;0.05). Enquanto a região de saúde de Lagarto, apresentou uma redução progressiva significativa de -1.5% (p&lt;0.05). As demais regiões apresentaram tendência neutra de óbitos por DM. Conclui-se que a tendência de mortalidade decorrente do DM no estado de Sergipe é alta e crescente, sendo o presente estudo, uma ferramenta útil para os profissionais de saúde otimizarem estratégias preventivas, diagnósticas e terapêuticas com ações contínuas e permanentes, com o intuito de reduzir a mortalidade dessa doença crônica, porém de carácter benigno.
TIBIAL BEARING COMPONENT FOR A KNEE PROSTHESIS WITH IMPROVED ARTICULAR CHARACTERISTICS

An orthopaedic knee prosthesis includes a tibial bearing component with articular features which operate to protect adjacent soft tissues of the natural knee, promote and/or accommodate desired articulation with an abutting femoral component, and facilitate expedient and effective implantation by a surgeon.
Users, safety, security and energy in transport infrastructure

The transport network across Europe faces challenges relating to carbon reduction targets, energy security, and depletion of natural resources, without sacrificing its efficiency and compromising mobility. In addition, the road and rail infrastructure in particular are ageing and require renewal. Simultaneously, advances in sensors, mobile communications, smart ticketing and ‘big data’ offer the potential for customers to become an active part of the transport operations system and have the information to make decisions – for transport to enable ‘mode agnostic’ personal and business travel and – for freight operators to have more resilience and better reliability in their systems. 
The European transport system faces also an unavoidable societal challenge, which is achieving new levels of resource-efficiency, environmental-friendliness, safe and seamless transport for the benefit of citizens, the economy and society.
In order to tackle the challenges and reap the benefits outlined above, infrastructure owners and transport operators will be required to work together, along with other crucial stakeholders, to share knowledge and cooperate in a way that will be beneficial to all parties, and this proposal seeks to facilitate this.
The objective of this project is to better understand the common challenges experienced across transport modes, bring representatives of transport modes together to share experience and skills and to develop a set of common research objectives. The project will draw upon the experience gained from the Joint European Transport platform with the focus on infrastructure operations, and will also focus on research objectives presented in the Forever Open Road programme and the work of the FORx4 - Forever Open Road, Railway, Runway and River – A Cross-modal transport initiative for research for which FEHRL produced a ‘Point of View’ document.
Study of tau strains to understand the phenotypic diversity of alzheimer’s disease: a step toward personalized therapies

Dementia represents a major challenge for our ageing societies. The number of citizens suffering from dementia in the EU is expected to reach 19 millions by 2050. Alzheimer’s disease (AD) is responsible for the vast majority of dementia cases. However there is still not a single available treatment that modifies the course of disease. Therefore, the development of innovative approaches to better understand the pathophysiology and ultimately treat patients must be a priority. This project aims to understand the determinants of the diversity of AD clinical phenotypes through the deep analysis of pathological variants of the tau protein. As the accumulation of Aβ peptide has long been considered a causative event in AD, most therapeutic approaches have targeted Aβ metabolism, but unsuccessfully. Modern biomarkers, have confirmed that the brain deposition of tau pathology, the other hallmark of AD, correlates much better with human cognition and neurodegeneration. Recently, it was shown that tau behaves like a prion and can spread from one neuron to another. Moreover, tau strains or conformers seem to template native tau and propagate the pathological conformation with high fidelity. Discrete tau strains generate distinct aggregates morphology or patterns of neuronal vulnerability. I postulate that different strains of tau are responsible for the variability of AD and may determine the progression rate, gender differences or clinical expression. Therefore, my objective is to develop the technologies to identify tau strains signatures in distinct AD phenotypes. In particular, I plan to develop and optimize biosensor cell lines that sensitively detect tau strains from human brain samples and cerebrospinal fluid, and characterize respective repertoire of tau strains. Understanding AD heterogeneity would potentially increase our ability to take care of every individual patient. In addition, this work could lead to the development of biomarkers and novel targeted therapies.
Landscape and forest exploitation at the ancient Neolithic site of La Draga (Banyoles, Spain)

This work is focused on the use of firewood by the first farming communities of the settlement of La Draga (Banyoles, Spain). The two occupation phases have been dated between 5324 and 4980 cal. bc. Charcoal remains are used to represent the vegetation landscape. The comparison of the charcoal analysis data with other archaeobotanical studies carried out at the site enables an appreciation of how wood resources were used and the impact of this use on the environment. A total of 22 taxa have been identified; riparian communities and oak forests were predominant in the surroundings and provided firewood as well as wood for other uses. Deciduous Quercus sp. and Laurus nobilis make up the largest part of the identified remains. Lakeside vegetation and the deciduous forests suffered the first impact of the farming communities. In the more recent phase, Buxus sempervirens was also used intensely. The importance of box may have been the result of the greater expansion of these taxa, as a result of the degradation of vegetation in the surroundings.
Bell’s inequality tests via correlated diffraction of high-dimensional position-entangled two-photon states

Bell inequality testing, a well-established method to demonstrate quantum non-locality between remote two-partite entangled systems, is playing an important role in the field of quantum information. The extension to high-dimensional entangled systems, using the so-called Bell-CGLMP inequality, points the way in measuring joint probabilities, the kernel block to construct high dimensional Bell inequalities. Here we show that in theory the joint probability of a two-partite system entangled in a Hilbert space can be measured by choosing a set of basis vectors in its dual space that are related by a Fourier transformation. We next propose an experimental scheme to generate a high-dimensional position-entangled two-photon state aided by a combination of a multiple-slit and a 4 f system, and describe a method to test Bell's inequality using correlated diffraction. Finally, we discuss in detail consequences of such Bell-test violations and experimental requirements.
Tools for the design and modelling of new markets and negotiation mechanisms for a ~100% renewable european power systems

Tools for the Design and modelling of new markets and negotiation mechanisms for a ~100% Renewable European Power System


The objective of this project is to develop and test an innovative electricity market design that can meet society’s needs in a (near) 100% renewable power system. Such a long-term sustainable market design needs to provide efficient operational and investment incentives for an electricity system that is characterized by a high share of variable renewable energy sources, that is highly integrated with sectors such as home heating and cooling and transport, and needs to provide efficient incentives for the participation of all demand, from households to industrial consumers. It needs to provide security of supply by ensuring sufficient controllable electricity generation capacity without becoming too costly. And despite the variability of solar and wind energy the price risk must be limited: for investors, so the cost of capital does not become too high, and for consumers so they are not exposed to unmanageable swings in their energy expenses.

In this project, a market design will be developed that meets these objectives. It will be tested in a sophisticated simulation environment in which real-world characteristics such as actors’ limited foresight into the future and risk aversion are included. The performance of the market design - with respect to quantitative indicators such as security of supply, average costs to consumers and investment cost recovery - will be compared to a benchmark calculation of an optimal power system, which will also be developed in this project. We will involve representatives of all key stakeholder groups - consumers, large and small power generators, network operators and government in all phases of the process, in the market design as well as the development of the optimization and simulation models, in order to ensure the social acceptability of the research process and outcomes.
5:45 PM SALIENCE MATTERS: BRAIN POTENTIALS DISTINGUISH PREMORBID ATTENTION PROBLEMS AMONG CHILDREN AT-RISK FOR SCHIZOPHRENIA

Background: A robust marker of brain dysfunction in schizophrenia (Cohen’s d=0.89) is reduction in amplitude of the P3 (or P300) event-related potential (ERP) that indexes attention and working memory processes. It is elicited typically using a two-tone auditory oddball paradigm that presents infrequent task-relevant target stimuli (which require a behavioural response) within a train of frequent task-irrelevant non-target (or standard) stimuli. The P3 amplitude reduction to target stimuli is present at the chronic and ﬁrst-episode phases of schizophrenia, and may predict transition to psychosis among at-risk adolescents/young adults. We sought to characterise potential premorbid brain function abnormalities among at-risk children aged 9-12 years in detail, using an auditory novelty oddball task variant that dissociates an earlier, automatic frontocentral P3a subcomponent elicited by infrequent task-irrelevant salient novel stimuli from a later parietal P3b sub-component elicited by the infrequent task-relevant target stimuli. Methods: We examined brain function in two at-risk groups, including a group with family history of schizophrenia (FHx; n=20) and a group of children presenting a triad of replicated antecedents of schizophrenia (ASz; n=20), namely (i) psychotic-like experiences; (ii) a social, emotional, or behavioural problem; and (iii) a speech-and/or-motor developmental delay or abnormality. At-risk groups were compared with a group of typicallydeveloping (TD; n=28) peers who had no family history or antecedents of schizophrenia. Groups did not differ signiﬁcantly on age, sex, ethnicity, socio-economic status, or handedness. Three group (FHx, ASz, TD) x three stimulus (targets, novels, non-targets) x ﬁve site (Fz, FCz, Cz, CPz, Pz) repeated-measures ANOVAs on peak P3 amplitude and latency data were conducted, and were repeated as ANCOVAs to control for poorer intellectual function (IQ) among the at-risk groups relative to TD children. Results: A signiﬁcant group-by-condition interaction indicated reduced novelty P3a amplitude, but not target P3b or non-target P3 amplitudes, in both at-risk groups relative to TD children. This result remained after correcting for IQ differences between groups. No latency differences were observed. Discussion: At-risk children aged 9-12 years, both those with family history and those presenting multiple childhood antecedents, display disturbances in frontal mechanisms supporting involuntary attention orienting to salient stimuli, while more conscious parietal mechanisms supporting stimulus evaluation and context updating are, as yet, unaffected in these children. The latter may emerge more proximally to transition to psychosis; 48month follow-up assessments are underway to ascertain the evolution of these components as participants mature through adolescence.
Groundwater residence time and movement in the Maltese islands – A geochemical approach

The Maltese Islands are composed of two limestone aquifers, the Upper and Lower Coralline Limestone separated by an aquitard, the ‘Blue Clay’. The Lower Coralline Limestone is overlain in part by the poorly permeable Globigerina Limestone. The upper perched aquifers are discontinuous and have very limited saturated thickness and a short water level response time to rainfall. Frequent detections of coliforms suggest a rapid route to groundwater. However, the unsaturated zone has a considerable thickness in places and the primary porosity of the Upper Coralline Limestone is high, so there is likely to be older recharge by slow matrix flow as well as rapid recharge from fractures. Measurement of SF6 from a pumping station in a deep part of one of the perched aquifers indicated a mean saturated zone age of about 15 years. The Main Sea Level aquifers (MSL) on both Malta and Gozo have a large unsaturated thickness as water levels are close to sea level. On Malta, parts of the aquifer are capped by the perched aquifers and more extensively by the Globigerina Limestone. The limited detection of coliform bacteria suggests only some rapid recharge from the surface via fractures or karst features. Transmissivity is low and tritium and CFC/SF6 data indicate that saturated zone travel times are in the range 15-40 years. On Gozo the aquifer is similar but is more-extensively capped by impermeable Blue Clay. CFC data show the saturated zone travel time is from 25 years to possibly more than 60 years. Groundwater age is clearly related to the extent of low-permeability cover. The δ13C signature of groundwater is related to the geochemical processes which occur along the flowpath and is consistent with residence time ages in the sequence; perched aquifers<Malta MSL<Gozo MSL. The 18O and 2H enriched isotopic signature of post 1983 desalinated water can be seen in more-modern groundwater, particularly the urbanised areas of the perched and Malta MSL aquifers. In all aquifers, movement of solutes from the surface travelling slowly through the matrix provide a long term source of groundwater contaminants such as nitrate.
Kont: Computing Tradeoffs in Normative Multiagent Systems

We propose Kont, a formal framework for comparing normative multiagent systems (nMASs) by computing tradeoffs among liveness (something good happens) and safety (nothing bad happens). Safety-focused nMASs restrict agents' actions to avoid undesired enactments. However, such restrictions hinder liveness, particularly in situations such as medical emergencies. We formalize tradeoffs using norms, and develop an approach for understanding to what extent an nMAS promotes liveness or safety. We propose patterns to guide the design of an nMAS with respect to liveness and safety, and prove their correctness. We further quantify liveness and safety using heuristic metrics for an emergency healthcare application. We show that the results of the application corroborate our theoretical development.
Identification of the Coexisting HER2 Gene Amplification and Novel Mutations in the HER2 Protein-Overexpressed Mucinous Epithelial Ovarian Cancer

Although overexpression, amplification, and somatic mutation of the HER2 gene have been noted in various types of human cancers, we report here for the first time that novel mutations and amplification of the HER2 gene occurred concomitantly in mucinous epithelial ovarian cancer (EOC).Twenty-seven tissue microarray samples from EOC patients were analyzed by immunohistochemistry (IHC) with Dako c-erb-B2 antibody and subsequently were examined by fluorescence in situ hybridization (FISH) with the Abbott PathVysion HER2 DNA Probe Kit. HER2 gene, exon 18-24, encoding a tyrosine kinase domain, was analyzed by polymerase chain reaction (PCR) and direct sequencing.The FISH-IHC paired results confirmed 19 concordant negative results and 3 concordant positive results. Moreover, all 4 HER2-amplified cases were of the mucinous type, whereas the remaining 23 HER2-nonamplified cases were of the nonmucinous type. The 4 mucinous EOC cases with HER2 gene amplification were selected and further analyzed for HER2 gene mutations. Data revealed that somatic mutations were present in 2 cases (R970W and E971G), but absent in the other 2 cases.HER2 protein overexpression correlated significantly with HER2 gene amplification in EOC (P = 0.027). It is surprising that all 4 cases of mucinous EOC showed HER2 gene amplification confirmed by FISH testing. However, we suppose that increasing the number of cases would possibly modify the results. This study also showed that both HER2 gene amplification and somatic mutations are not mutually exclusive in mucinous EOC. Further studies are warranted to investigate the potential role of anti-HER2 therapy.
Cardiac Magnetic Resonance and the Need for Routine Cardiac Catheterization in Single Ventricle Patients Prior to Fontan: A Comparison of 3 Groups

This study investigated whether cardiac magnetic resonance (CMR) and echocardiography (echo) can replace catheterization (cath) for routine evaluation prior to Fontan and under what circumstances CMR and cath are used together. Routine cath prior to Fontan has been utilized for years; noninvasive methods, however, may be sufficient. This study reviews clinical data in 119 consecutive patients investigating 3 groups: those who underwent CMR alone (MR; n = 41), cath alone (C; n = 41), or both cath and CMR (C+M; n = 37) prior to Fontan. No clinically significant differences were noted in patient characteristics, hemodynamics, or clinical status prior to or after surgery between the C and MR groups. CMR added information in 82%. There were no discrepant findings between CMR and cath data in the C+M group. Diagnostic success was ≥95% in all groups. Of those undergoing Fontan completion, the C+M group had similar outcomes to C and MR; C and CMR were utilized in combination to assess aortopulmonary collaterals or the need for an intervention or evaluate its success. Echo could not delineate pulmonary arterial anatomy in 46% to 53% of patients. The C+M and C groups were exposed to 6.8 ± 4.1 mSv of radiation. Single ventricle patients not requiring an intervention can undergo successful Fontan completion with CMR and echo alone with similar short-term outcomes to C, which was used as a control, preventing an invasive test and exposure to radiation. CMR can add information in a significant number of patients. Cath and CMR are utilized together for interventions and assessment of aortopulmonary collaterals.
Subvenção para a empresa Grzegorz Wyszomierski «Aquaris» para financiar as atividades correntes e assegurar as suas operações quotidianas.

O projeto pressupõe uma subvenção para a empresa Grzegorz Wyszomierski «Aquaris», que sofreu em resultado da pandemia de COVID-19. Devido à pandemia, o volume de negócios diminuiu significativamente. A subvenção deve assegurar que a atividade da empresa é mantida por um período de, pelo menos, três meses civis.
Effects of wind-driven circulation on river intrusion in Lake Tegel: modeling study with projection on transport of pollutants

Prediction of mixing intensity of water masses in riverine Lake Tegel (Berlin, Germany) can be used to trace the fate of pollutants that enter the lake through several inflows. Because the contributions of each inflow have not yet been quantified and because the lake features complex bathymetry and numerous islands, a hydrodynamic circulation model with high spatial resolution and dynamic wind forcing is useful. We applied the two-dimensional version of the Princeton Ocean Model to separate the influences of wind and river discharge on the currents and mass transport in Lake Tegel. For model validation, we compared the simulation results with 1 year of electrical conductivity data, which was used as a conservative tracer to distinguish between water from the River Havel and water supplied by a smaller second inflow. Calculation of currents alone is insufficient to investigate water exchanges between rivers and lakes, especially when several islands create multiple pathways for river intrusion. Therefore, mass transport simulations are applied. Our calculations based on archetypical scenarios indicate that the proportion of (polluted) water from the River Havel in the main basin of Lake Tegel fluctuates with river discharge and wind, which either amplify or neutralize each other.