SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Glomerular Filtration Rate in Evaluation of the Effect of Iodinated Contrast Media on Renal Function

The purpose of this study was to use measured glomerular filtration rate (GFR), the reference standard of renal function, to assess the deleterious effect of iodinated contrast media on renal function. Such an effect has been traditionally defined as a greater than 0.5-mg/dL increase in serum creatinine concentration or a 25% or greater increase 24-72 hours after the injection of iodinated contrast medium.This pilot investigation was focused on the consequences of clinically indicated IV injection of iodinated contrast media; intraarterial injection was excluded. One hundred thirteen patients with normal serum creatinine concentrations were enrolled in an approved protocol. At random, as chosen by one of the investigators, patients underwent imaging with one of three monomeric agents (iopamidol 300, iopromide 300, iohexol 300) and one dimeric agent (iodixanol 320). Measured GFR was determined immediately before CT and approximately 3 and 72 hours after the contrast injection for the CT examination. Iodinated contrast medium, a glomerular filtrate with no tubular excretion or reabsorption, was the GFR marker. Measured GFR was determined by x-ray fluorescence analysis with nonisotopic iodinated contrast media.Monomeric and dimeric contrast agents in diagnostic CT volumes (based on bodyweight and imaging protocol) did not induce a significant change in measured GFR (95% confidence by Wilcoxon test), suggesting that use of the evaluated contrast media will not lead to more than a 12% variation.The three monomeric agents studied and the one dimeric agent were equivalent in terms of lack of a significant effect on measured GFR when administered to patients with a normal GFR.
Automatic acquisition of taxonomies in different languages from multiple Wikipedia versions

In the last years, the vision of the Semantic Web has led to many approaches that aim to automatically derive knowledge bases from Wikipedia. These approaches rely mostly on the English Wikipedia as it is the largest Wikipedia version and have lead to valuable knowledge bases. However, each Wikipedia version contains socio-cultural knowledge, i.e. knowledge with specific relevance for a culture or language. One difficulty of the application of existing approaches to multiple Wikipedia versions is the use of additional corpora. In this paper, we describe the adaptation of existing heuristics that make the extraction of large sets of hyponymy relations from multiple Wikipedia versions with little information about each language possible. Further, we evaluate our approach with Wikipedia versions in four different languages and compare results with GermaNet for German and WordNet for English.
Digital photography in skin cancer screening by mobile units in remote areas of Brazil

Non-melanoma skin cancer (NMSC) is one of the most common neoplasms in the world. Despite the low mortality rates, NMSC can still cause severe sequelae when diagnosed at advanced stages. Malignant melanoma, the third most common type of skin cancer, has more aggressive behavior and a worse prognosis. Teledermatology provides a new tool for monitoring skin cancer, especially in countries with a large area and unequal population distribution. This study sought to evaluate the performance of digital photography in skin cancer diagnosis in remote areas of Brazil.A physician in a Mobile Prevention Unit (MPU) took four hundred sixteen digital images of suspicious lesions between April 2010 and July 2011. All of the photographs were electronically sent to two oncologists at Barretos Cancer Hospital who blindly evaluated the images and provided a diagnosis (benign or malignant). The absolute agreement rates between the diagnoses made by direct visual inspection (by the MPU physician) and through the use of digital imaging (by the two oncologists) were calculated. The oncologists' accuracy in predicting skin cancer using digital imaging was assessed by means of overall accuracy (correct classification rate), sensitivity, specificity and predictive value (positive and negative). A skin biopsy was considered the gold standard.Oncologist #1 classified 59 lesions as benign with the digital images, while oncologist #2 classified 27 lesions as benign using the same images. The absolute agreement rates with direct visual inspection were 85.8% for oncologist #1 (95% CI: 77.1-95.2) and 93.5% for oncologist #2 (95% CI: 84.5-100.0). The overall accuracy of the two oncologists did not differ significantly.Given the high sensitivity and PPV, Teledermatology seems to be a suitable tool for skin cancer screening by MPU in remote areas of Brazil.
Molecular architecture of heteromeric kainate receptor complexes

Kainate receptors (KARs) are glutamate-gated ion channels (iGluRs) known as neuronal circuit modulators. Because of their involvement in epilepsy and mood disorders, they represent an important pharmacological target. Over the past decade, we have learned a lot about synaptic KARs, but their assembly, function and pharmacology remain elusive compared to the closely-related alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR). During my PhD, I used electrophysiology to study the functional properties of KARs and AMPARs associated with auxiliary proteins to gain insights into their roles at neuronal synapses.

In the proposed research project, I plan to use structural methods such as X-ray crystallography and single-particle cryo-electron microscopy and tomography to address the questions brought by my PhD thesis work. Specifically, I will combine the functional knowledge and skills that I have acquired with the structural expertise of the host laboratory to inquire about the structural assembly of synaptic KARs and especially the interactions between the different KAR subunits and their synaptic binding partners. Combined with the functional analysis of these interactions, this work will provide valuable information for a deeper understanding of synaptic complexes at the molecular level.
METHODS AND DEVICES FOR SAMPLE COLLECTION AND SAMPLE SEPARATION

Methods and devices are provided for sample collection and sample separation. In one embodiment, a device is provided for use with a formed component liquid sample, the device comprising at least one sample inlet for receiving said sample; at least a first outlet for outputting only a liquid portion of the formed component liquid sample; at least a second outlet for outputting the formed component liquid sample at least a first material mixed therein.
The evolution of menstruation in primates

Menstruation is a recent evolutionary innovation in primates: the trait is present in some species (humans, baboons) but not in closely related others (orangutans, vervets). In the latter and in most mammals, the uterine endometrium is reabsorbed at the end of the cycle instead of being shed when fecundation has not occurred. The molecular and genetic underpinnings of this complex process are not fully understood, despite its critical involvement in gynaecological conditions. I propose to discover the molecular mechanisms leading to menstruation by comparing the uterine linings from five primate species at the cellular, functional and genetic levels. The objectives are to identify the gene networks and non-coding regulatory elements that control the advent of menstruation in primates, and to understand how this genetically inherited trait was acquired in primate genomes during the evolution of the human lineage.
In Aim 1, I will leverage single-cell transcriptomics to uncover the cellular composition and marker modifications that differentiate the uterine linings of menstruating and non-menstruating primates. 
In Aim 2, I will use deep transcriptomics and accessible chromatin assays on sorted endometrial cell populations to identify genes and non-coding regulatory regions differentially activated in menstruating species. This analysis will reveal the molecular pathways, regulation networks and cellular interplay involved in uterine tissue shedding vs. reabsorption.
In Aim 3, I will replace these modifications within the context of primate genome evolution: I will elucidate the mutational dynamics by which genetic novelty has emerged during the adoption of menstruation, and how the functional divergence of the endometrium compares to other reproductive and somatic tissues.
This project will enhance our understanding of a key physiological trait for human reproduction as well as a dramatic example of functional innovation in the primate lineage.
DAS GEDÄCHTNIS EINES TERRITORIUMS, VOM ARCHIV BIS ZUM VIRTUELLEN

DAS PROJEKT UMFASST DREI AKTIVITÄTEN: 1) DIGITALISIERUNG VON PAPIERDOKUMENTEN, AUDIOVISUELLEN FOTOGRAFIEN IN DEN ARCHIVEN 2) REALISIERUNG VON 15 AUDIOVISUELLEN EINHEITEN AUF DEN BESUCHSPFADEN 3) SCHAFFUNG EINES VIRTUELLEN MUSEUMS AUF EINER BESTIMMTEN WEBSITE
METHOD FOR GENERATING PROGRAM CODE

The present invention describes a method for generating program code for processing a data flow defined by plurality of bit fields comprising the steps: entering a model of the program code having a datagram part, which comprises a graphic representation of the data flow, and a processing part, wherein the entering of the datagram part comprises a generation of a graphic from a plurality of graphic elements on a display device, wherein each graphic element represents one bit field of the data flow, wherein an arrangement of the graphic elements on the display system represents an arrangement of the bit fields in the data flow, wherein an identifier, position, length, data type, and bit order is determined for each bit field, wherein the entering of the processing part comprises an entering of an expression, wherein the expression contains an operand and an operator affecting the operand, wherein the operand comprises the identifier of one of the bit fields; and converting the model into the program code, wherein the expression having the operand and the operator is converted from the processing part of the model into an instruction of the program code, wherein the instruction in the program code extracts a value of the bit field, determined by the identifier contained in the operand, from the data flow and assigns this value to a variable, or the instruction writes the value of a variable into the bit field determined by the identifier contained in the operand, wherein the variable has the data type determined for the bit field determined by the identifier or has a data type equivalent to the data type determined for the bit field determined by the identifier, and wherein the operator is converted into a command affecting the variable or into a control structure of the program code affecting the variable.
Avaliação da bioequivalência entre duas formulações de rivaroxabana – 20 mg comprimido revestido – administradas em jejum e pós-prandial em voluntários sadios

Objetivo: O objetivo deste trabalho foi avaliar a bioequivalência entre duas formulações de rivaroxabana 20 mg comprimido revestido, sendo a formulação teste produzida por Sanofi Medley, Brasil e a formulação referência (Xarelto®) comercializada por Bayer S/A. Métodos: Os estudos foram conduzidos em voluntários sadios de ambos os sexos e as formulações foram administradas em dose única, sob o estado de jejum e pós-prandial. Cada estudo foi conduzido de maneira independente, sendo ambos do tipo aberto, randomizado e com intervalo (washout) de sete dias entre os períodos. O estudo em jejum foi realizado em quatro períodos, com 48 voluntários, enquanto o pós-prandial foi realizado em dois períodos, com 36 voluntários. Resultados: Na administração em jejum, a razão entre a média geométrica da formulação teste e referência (T/R) de Cmáx foi de 100,77%, com intervalo de confiança de 90% (IC 90%) de 94,24% a 107,76%. Para ASC0-t, a razão T/R foi de 100,65%, com IC 90% de 96,13% a 105,39%. Na administração pós-prandial, a razão T/R de Cmáx foi de 110,63%, com IC 90% de 102,39% a 119,54%. Para ASC0-t, a razão T/R foi de 104,65%, com IC 90% de 98,44% a 109,12%. Conclusões: As formulações teste e referência foram consideradas estatisticamente bioequivalentes em ambas as condições de administração, de acordo com os critérios exigidos pela Agência Nacional de Vigilância Sanitária (Anvisa). A formulação teste foi registrada na Anvisa e disponibilizada para comercialização, contribuindo, assim, para a ampliação da disponibilidade do tratamento para doenças tromboembólicas e para a redução de custos ao paciente e ao Sistema Único de Saúde.
Patient Recall of Health Care Events and Time to Diagnose a Suspected Ovarian Cancer

Abstract Introduction Patient recall is often used by clinicians to create a history of care leading to consultation with a gynecologic oncologist. Although patient recall may be an efficient method to explore the context of the patient's concerns, the accuracy of recall and its potential impact on care are unknown. This study sought to explore the consistency of patient recall compared with data found in health care records. Patients and Methods This study enrolled 105 eligible patients who were referred to a gynecologic oncologist for suspected ovarian cancer. Ninety-one of these patients were interviewed regarding symptoms, health care events, and the dates leading to diagnosis. The medical records of these patients from all previous providers were obtained and data were abstracted. The intraclass correlation coefficient (intraclass correlation coefficient, ICC[3,1]) was used to examine correspondence between recall and medical record data. Results There was low correspondence between patient recall and the medical record for time to diagnosis (ICC = 0.12; 95% confidence interval [CI] = −0.09 to 0.33; P = .12) and health care events (0.15; 95% CI, −0.05 to 0.348; P = .008). Conclusions There should be limited confidence in information obtained from patient recall given the inconsistency between recall and actual dates and events.
Open innovation ecosystem for sustainable plant-based nano-enabled biomaterials deployment for packaging, transport and consumer goods

INN-PRESSME aims at developing and implementing a sustainable OITB to support European companies to scale up their nano-enabled biomaterials and processes from TRL 4-5 to 7. We will focus on (nano)cellulose, bioplastics and natural fibres, combined with nanotechnology approaches to tailor biobased materials with properties and functionalities (barrier, antibacterial properties, improved corrosion or chemical resistance, etc.) that equal or outperform their fossil counterparts at competitive prices. INNPRESSME gathers 16 pilot lines, organized in routes and processes for feedstock conversion (PLA, PHA, fibre-based, cellulose-based), formulation and transformation and processing of bio-based material to high added value products.
INN-PRESSME is a joint collaborative net of 27 partners from 10 EU countries from North (Fi, Nor, Swe, UK, Be), South (Sp, It, Fr) and central Europe (Ge, Po). All technical and market oriented services are provided by specific partners, include equipment and methods for processing, fast and accurate/reliable characterization, scaling up, nanosafety, eco-design and circular economy assessment (recyclability and biodegradability), product certification, digitization of the OITB, sustainable OITB´ business plan, technology transfer, support for funding, networking activities. The value proposition will be validated for 3 targeted mass markets (packaging, energy/transport, and consumer goods sectors) with 9 test cases co-developed with Early Adopters (7 IND, 1 SME) and with additional test cases through open calls. All this will secure the smooth transition of the new material concepts to the market, for a cumulated turnover of about 56M€ by 2029. Additionally, for maximizing the impacts on SMEs, the OITB will rely on a strong network of European clusters and initiatives and on an efficient promotional campaigns including towards the ECCP members or regional initiatives funded by ERDF. These services will be available through single entry point.
Piezoelectronic transduction memory device

Computer clock speeds have not increased since 2003, creating a challenge to invent a successor to CMOS technology able to resume performance improvement. The key requirements for a viable alternative are scalability to nanoscale dimensions – following Moore’s Law – and simultaneous reduction of line voltage in order to limit switching power. Achieving these two aims for both transistors and memory allows clock speed to again increase with dimensional scaling, a result that would have great impact across the IT industry.
We propose to demonstrate an entirely new low-voltage, memory element that makes use of internal transduction in which a voltage state external to the device is converted to an internal acoustic signal that drives an insulator-metal transition. Modelling based on the properties of known materials at device dimensions on the 15 nm scale predicts that this mechanism enables device operation at voltages an order of magnitude lower than CMOS technology while achieving 10GHz operating speed; power is thus reduced two orders.
Allocating Damage Compensation in a Federalist System: Lessons from Spatially Resolved Air Emissions in the Marcellus

The benefits and impacts of unconventional natural gas development are realized at different spatial scales, calling into question the appropriate jurisdictional level at which to set and enforce environmental policy. This paper evaluates impact fee allocation under Pennsylvania Act 13, which authorizes Commonwealth payments to Pennsylvania counties to offset damages from unconventional natural gas extraction in exchange for consolidated state-level regulatory authority. We evaluate the adequacy of damage compensation allocation for impacts that are spatially and temporally removed from the well site, using the air emissions associated with natural gas wastewater transport as a case study. Wastewater transport from wells eligible for 2011 impact fee disbursement calculations generated an estimated $11.6 million in air emission damages from 2004 to 2013, with 35% of damages occurring out-of-state and an average of 94% of damages occurring out-of-county. We find that compensatory payments from Pennsylvania Act 13, which are based upon the number of wells drilled in a county in a single year, inadequately account for spatially and temporally distributed impacts from wastewater transport. This case study of Pennsylvania Act 13 highlights potential issues associated with central regulators using compensatory payments as a means of resolving jurisdictional conflict. In cases where the central regulator benefits from the polluting activity, we argue that there is incentive to focus compensation on local damages and undervalue regional and spatially distributed damages in compensation algorithms.
Structural positioning of nurse leaders and empowerment

To analyse the reporting structures of nursing leaders of publicly funded hospitals and seek both the views of nurse leaders and Chief Executive Officers/Chief Operating Officers on the structural positioning of nurse leaders in the organisation.Concern that the continuing restructuring within hospital structures and focus on economic outputs in health services is diminishing the value of nursing leadership.Qualitative surveys with Nursing leaders and Chief Executive Officers of public hospitals.Seventeen Directors of Nursing and 10 Chief Executive Officer/Chief Operating Officers' responses were received using two semi-structured questionnaires. Themes were developed from data coded and analysed by hand.Four broad themes emerged from analysis of the data: (1) variable positional reporting between Director of Nursing and Chief Executive Officers occurred; (2) variable levels of inclusion and influence at the executive decision-making level; (3) ambiguous financial responsibilities and accountabilities held by Director of Nursing; and (4) blurred lines existed between operational and professional reporting lines. Findings unique to the research indicate that the varying levels of visibility and inclusion impact on the structural positioning of nurse leaders which influences authority and empowerment.Responses from the data analysis indicate that the structural power of nurse leaders defined by the factors of opportunity, power and proportion were hindered by dual accountability reporting lines and a lack of financial control.The structural positioning of nurse leaders is vital to ensure that they are empowered and able to meet the adaptations required in a changing environment that supports the delivery of effective, quality healthcare.
Implement a european-wide coordination of research and innovation programs on raw materials to strengthen the industry competitiveness and the shift to a circular economy

Building on the experience of ERA-MIN FP7 funded project, the objective of the ERA-NET Cofund on Raw Materials (ERA-MIN 2) is to strengthen the coordination of national and regional research programmes in the field of non-energy non-agricultural raw materials by implementing one joint call for proposals resulting in grants to third parties with EU co-funding.
In line with the integrated strategy proposed in the EU Raw Materials Initiative and the Strategic Implementation Plan of the European Innovation Partnership on Raw Materials, the ERA-MIN 2 Call topics will address the three segments of the non‐energy non-agricultural raw materials: metallic, industrial and construction minerals and will cover the whole value chain: exploration, extraction, processing/refining, as well as recycling and substitution of critical raw materials. 
ERA-MIN 2 supports the objectives of the EIP on Raw Materials, particularly in the area of research and innovation co-ordination; improve synergy, co-ordination and coherence between regional, national and EU funding in the relevant research fields through international collaboration; reduce fragmentation of raw materials research and innovation efforts across Europe; improve use of human and financial resources in the area of raw materials research and innovation.
As measures to maximise impact, ERA-MIN 2 will cooperate with the existing initiatives, projects and associations, by establishing an effective communication aiming to assure that all dissemination activities, including the promotion and follow up of project results, will reach out to a wider audience of stakeholders, therefore strengthening the raw material community.
To further increase its impact and to better fulfil the overarching objectives, ERA-MIN-2 will develop and implement at least two additional joint calls without EU co-funding, in topics of common interest and based on the updated Roadmap provided by CSA VERAM.
On-line control of multi-terminal HVDC systems connected to offshore wind farms using the OPF-based multi-agent approarch

Multi-terminal HVDC systems are an attractive option to connect offshore wind farms to onshore grids. Although scheduling the multi-terminal HVDC system is based on forecasted wind power, the forecasted values may differ from their real time ones. This paper presents a new controller based on multi-agent system which optimally tries to follow the variations of real time wind power outputs. Since a fast optimal power flow algorithm is needed, a convexified AC-OPF model which can be efficiently solved through interior point methods (IPMs) is embedded into the proposed online controller. Simulations are carried out and validated using GAMS platform and MATLAB/Simulink.