SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Management of women with BRCA1/2 mutation-associated breast cancer

SUMMARY BRCA mutation-associated breast cancer differs from sporadic breast cancer as studies show that mutation carriers have a higher risk of breast and ovarian cancer, and also have differential sensitivity to chemotherapeutic agents. With the more readily available BRCA genetic testing, BRCA mutation status should be considered in high-risk women, including women who are diagnosed with breast cancer at an early age, have a strong family history or have tumors with triple-negative status. This article reviews the risk-reducing surgeries, including the prophylactic contralateral mastectomy and bilateral salpingo-oophorectomy, in women diagnosed with BRCA-associated breast cancer. Additionally, the sensitivity of BRCA-defective breast cancer cell lines to platinum cytotoxic compounds, PARP and endocrine therapy is reviewed.
Towards programmable cyber-physical systems: a symbolic control approach

Cyber-physical systems (CPS) consist of computational elements monitoring and controlling physical entities. The main objective of the PROCSYS project is to propose a general framework for the design of programmable CPS that will allow engineers to develop advanced functionalities using a high-level programming language for specifying the behaviours of a CPS while abstracting the details of the physical dynamics. Controllers enforcing the specified behaviours will be generated from a high-level program using an automated model-based synthesis tool. Correctness of the controllers will be guaranteed by following the correct by construction synthesis paradigm through the use of symbolic control techniques: the continuous physical dynamics is abstracted by a symbolic model, which is a purely discrete dynamical system; an interface consisting of low-level controllers is designed such that the physical system and the symbolic model behaves identically; a high-level symbolic controller is then synthesized automatically from the high-level program and the symbolic model. We will develop a high-level programming language, based on the intuitive formalism of hybrid automata, which will enable to specify a rich set of behaviours while enabling the development of efficient controller synthesis algorithms. The project will also tackle the two main bottlenecks in the area of symbolic control, which will enable its use in challenging real-life applications. Firstly, scalability of symbolic control will be achieved by the computation of more compact symbolic models and by controller synthesis algorithms that require only partial exploration of the symbolic models. Secondly, robustness will be ensured at all levels of control by developing novel algorithms for the synthesis of robust interfaces and of symbolic controllers. The algorithms developed in the project will be implemented in a symbolic control toolbox, which will enable the use of our approach by systems engineers.
Non-coincidence of quenched and annealed connective constants on the supercritical planar percolation cluster

In this paper, we study the abundance of self-avoiding paths of a given length on a supercritical percolation cluster on \(\mathbb{Z }^d\). More precisely, we count \(Z_N\), the number of self-avoiding paths of length \(N\) on the infinite cluster starting from the origin (which we condition to be in the cluster). We are interested in estimating the upper growth rate of \(Z_N\), \(\limsup _{N\rightarrow \infty } Z_N^{1/N}\), which we call the connective constant of the dilute lattice. After proving that this connective constant is a.s. non-random, we focus on the two-dimensional case and show that for every percolation parameter \(p\in (1/2,1)\), almost surely, \(Z_N\) grows exponentially slower than its expected value. In other words, we prove that \(\limsup _{N\rightarrow \infty } (Z_N)^{1/N}{<}\lim _{N\rightarrow \infty } \mathbb{E }[Z_N]^{1/N}\), where the expectation is taken with respect to the percolation process. This result can be considered as a first mathematical attempt to understand the influence of disorder for self-avoiding walks on a (quenched) dilute lattice. Our method, which combines change of measure and coarse graining arguments, does not rely on the specifics of percolation on \(\mathbb{Z }^2\), so our result can be extended to a large family of two-dimensional models including general self-avoiding walks in a random environment.
HEATING DEVICE FOR VACUUM PRESSES

The invention relates to a heating device for vacuum presses comprising a device that acts as a support for structures (5) on top of which are positioned supports (6) for heat sources (7). Said structures can be moved longitudinally by means of a guide device on which the heat source supports can also move. The aforementioned supports are adjustable and extractable while the heat sources can be adjusted. The inventive device can be used for the localised heating of the materials to be heated in the desired areas. The invention is suitable for the production of heating devices for vacuum presses.
RIBOZYMES TARGETED TO IL-15 mRNA

Enzymatic RNA molecules which cleave mRNA encoding IL-15, are provided. The constructs of the invention include regulatory regions for expression in cells, cell lines, or transgenic non-human animals. The ribozymes of the invention are directed against IL-15 mRNA and are useful in treating rheumatoid arthritis.
Effacement / absence du sujet et fonction du genre neutre dans les langues slaves. Quelques observations à partir des idées de A. Potebnja et de A.M. Peškovskij

F. Giusti-Fici voit dans l’œuvre du linguiste russo-ukrainien A. Potebnja, continuateur de la pensée humboldtienne en Russie, une réflexion sur les constructions impersonnelles comme manifestations de la pensée non orienté sur l’agent, qui se réalisent dans l’impossibilité d’avoir un actant sujet en dépendance du prédicat.
Delphi method analysis: The role of regulation in the mobile operator business in Finland

Mobile communication has grown out of its original scope and scale. Mobile operators have played a significant role in this phenomenon. Since the mobile operator business is highly regulated, the effects of regulation on the industry have been analyzed. The potential effects in the years up to 2015 are also considered. The aim of this paper is to discuss the possibilities of a futures-oriented method — i.e. the Delphi method, to estimate the effect of regulation on the mobile operator business. The challenge is that the method was originally created to assess experts' opinions about the course of development of a certain technology or phenomenon in the future and then, by using a scenario technique, to draw conclusions about its possible futures. Now the Delphi method is also being used to estimate past development, i.e. experts' opinions of the causes and effects of laws and other regulations in the past few decades. The paper forms a part of a larger study, the aim of which is to analyze the effects of changes in the regulatory framework for the mobile operator industry in Finland. According to this research the ultimate goals of the regulator, set as early as in the middle of the 1980s, have been actualized: In Finland there are several competing nationwide mobile operators and the use of mobile phones is cheap compared to many other countries.
A Canadian Commentary on Constructive Expropriation Law Under NAFTA Article 1110

By virtue of the Constitution Act, 1982. Canada has established that some rights andfreedoms are beyond the reach ofgovernment. However, the protection of properly, especially with regard to the guaranteeing of compensation ifproperty is taken by the state, has not been elevated to this same level of constitutional protection. This article examines regulatory takings claims under Article 1110 ofthe North American Free Trade Agreement and provides an exposition of the law insofar as it has developed in the NAFTA context. It begins with a survey of constructive takings in international and domestic U.S. law and concludes by highlighting the obvious differences between the protection afforded to foreign NAFTA investors in Canada and domestic owners of properly when property is taken.
METHODS OF USING SMAD7 ANTISENSE OLIGONUCLEOTIDES BASED ON BIOMARKER EXPRESSION

Described herein are methods of treating inflammatory bowel disease (IBD) in a patient having IBD using SMAD7 antisense oligonucleotides.
QCD phase transition in a strong magnetic background

We investigate the properties of the deconfining/chiral restoring transition for two flavor QCD in the presence of a uniform background magnetic field. We adopt standard staggered fermions and a lattice spacing of the order of 0.3 fm. We explore different values of the bare quark mass, corresponding to pion masses in the range 200--480 MeV, and magnetic fields up to $|e|B\ensuremath{\sim}0.75\text{ }\text{ }{\mathrm{GeV}}^{2}$. The deconfinement and chiral symmetry restoration temperatures remain compatible with each other and rise very slightly ($l2%$ for our largest magnetic field) as a function of the magnetic field. On the other hand, the transition seems to become sharper as the magnetic field increases.
Resource Centers and Innovation for Craftsmanship

Because of trade globalisation, arts and crafts businesses are facing great difficulties. This is due to the individualism of artisans and artists, lack of financial and human resources and a reluctance to change design, production and sales habits. This consideration applies to any country. This appears as a paradox, since the Mediterranean has a strong tourist appeal, especially the Côte d'Azur, Corsica, Liguria and Sardinia (which regions are involved in the project with 7 partners).  Therefore, it is necessary to react by offering a structured project to the artisans and operators of the Franco-Italian tourism supply chain. This project follows the cross-border programmes Interreg Alcotra ARTisART and Interreg Marittimo Me-R; however, it is innovative and puts sharing and sustainable development at the centre of the action. This project sees innovation as a lever for sustainable development and provides businesses with shared competence and service centres. The programme partners wish to address this vital challenge to optimise the competitiveness of the companies and the attractiveness of the regions.  Through new creative experiences, this project should allow a diversified tourism offer as well as a cross-border cluster of arts and crafts. This project develops around trading and sharing places that will allow the actors of the tourism supply chain to join forces and gain visibility.  A transnational approach is essential for better economic and social cohesion between the areas concerned. It will reduce development inequalities, optimise business visibility and establish efficient trade and lasting cooperation.
Biodiversity drivers on islands and continents

Why do some regions encompass higher number of species? Which are the main drivers of biodiversity in different biogeographical areas and ecosystems? Many efforts have been made to decipher the main factors that play a key role in the patterns and processes that generate biodiversity and contribute to the structuring of communities at different spatial scales. Through a multidisciplinary approach, this project aims to shed light into the biogeographical and evolutionary processes that generate biodiversity, using multiple island and continent datasets to compare diversity drivers between model systems where distinct processes have shaped the current species composition. The feasibility of BIODIV ISLAND-CONT is supported by the extensive database provided by four different European funded projects, offering an invaluable tool to study the differences in community assembly of islands vs. continents. The project will be hosted by two high-quality European institutions: FMNH-UH in Finland and IPNA-CSIC in Spain, enhancing the reciprocal transfer of knowledge among different European partners. Overall, the goals proposed in this project will allow testing general macroevolutionary hypotheses of broad interest to the scientific community.
1921: ¿qué modelos heroicos para el centenario de la independencia centroamericana?

Independencia y unionismo van de la mano en Centroamérica. O por lo menos eso se intentó reafirmar en el marco de las conmemoraciones de 1921 a pesar del fracaso de la reconstrucción de la unión política. Estudiar los modelos heroicos que se celebraron durante estas festividades permite poner de realce los proyectos sociales en pugna, tanto a nivel nacional como regional. Por un lado, se actualizan los héroes oficiales, y por otro se incorporan nuevas figuras a los panteones en un intento por cuestionar una visión excluyente y homogénea de la nación heredada del siglo XIX. La circulación, negociación y apropiación de las figuras heroicas se estudian aquí principalmente a través de artículos de prensa y de textos escolares.
Emprendimiento sostenible y competitividad en México: el caso UNIVA

Las universidades juegan un rol importante en el fomento de las habilidades emprendedoras en los estudiantes, habilidades que, alineadas con innovación, se convierten en un factor clave para el desarrollo de las economías. Estas pueden acercar a los jóvenes al contexto empresarial, caracterizado por redes de apoyo que generan un entorno propicio para nuevas ideas de negocio. En este artículo presentamos el caso del Centro de Competitividad y Emprendimiento Sostenible de la Universidad del Valle de Atemajac, en México, donde consideramos la variedad de actividades curriculares ofrecidas a los estudiantes durante su proceso académico, alineadas con los Objetivos de Desarrollo Sostenible, que evalúan no solamente los beneficios económicos, sino también los sociales, ambientales y culturales. Los resultados muestran la importancia del empoderamiento educativo basado en una participación que involucra una asunción de responsabilidades por parte de los estudiantes.
Adaptive Real-Time Ship Detection and Tracking Using Morphological Operations

In this paper, we propose an algorithm that can efficiently detect and monitor multiple ships in real-time. The proposed algorithm uses morphological operations and edge information for detecting and tracking ships. We used smoothing filter with a <TEX>$3{\times}3$</TEX> Gaussian window and luminance component instead of RGB components in the captured image. Additionally, we applied Sobel operator for edge detection and a threshold for binary images. Finally, object labeling with connectivity and morphological operation with open and erosion were used for ship detection. Compared with conventional methods, the proposed method is meant to be used mainly in coastal surveillance systems and monitoring systems of harbors. A system based on this method was tested for both stationary and non-stationary backgrounds, and the results of the detection and tracking rates were more than 97% on average. Thousands of image frames and 20 different video sequences in both online and offline modes were tested, and an overall detection rate of 97.6% was achieved.
SIDELINK ANGULAR-BASED AND SL RRM-BASED POSITIONING

An apparatus 1100 for localizing a target UE (605,805) sidelink ("SL") positioning includes a processor 1105 configured to cause the target UE (605,805) to receive from a sidelink configuration source (610 or 635) SL PRS assistance data associated with SL reference signal transmissions e.g., beam transmissions (620a-620b), transmitted from one or more SL signal transmitting devices (e.g., 610, 615, 630). The target UE (605,805) receives transmitted SL signal information from the one or more SL signal transmitting devices (610, 615, 630) and performs SL signal angle of arrival ("AoA") measurements or reference signal received power ("RSRP") measurements for deriving angle of departure (AoD) mapped to the received SL RSRP measurements or performs SL radio resource management measurements ("SL-RMM") for determining an estimated location of the target UE (605,805) using SL-AoD, SL-AoA, SL-RMM positioning techniques or combinations thereof.
Understanding insect migration behaviour and pathways using individual tracking and radar

Migration involves the seasonal movement of large numbers of animals, usually due to shifts in resource availability. Migrants connect habitats and populations, and have significant effects on ecosystem processes. Insects are the most diverse and abundant group of terrestrial migrants, but in comparison to vertebrates, insect migration is poorly studied. In particular, we have little knowledge regarding the migratory pathways of insects, and their flight behaviour and orientation in relation to topographic barriers. Using a combination of state-of-the-art techniques, individual tracking and vertically-looking radar, I aim to identify migratory routes of insects in Europe, and investigate migratory behaviour in relation to topography. This action will be the first to track migrating insects in Europe using individual-based tracking. This unique combination of methods will provide insight into the migratory behaviour of insects at landscape and local scale and provide us with an unprecedented level of information regarding the mechanisms underlying insect migration. 

The objectives of the work packages in this project are:
WP 1: To investigate the influence of radio-transmitters on the flight behaviour of hawk moths in the laboratory. To investigate space-use and flight behaviour of hawk moths in the field. 

WP2: To elucidate migratory pathways of insects across Europe using individual tracking, and to understand migratory flight and orientation behaviour in relation to topography along these routes. We will also investigate which factors influence individual departure decisions and stopovers en route. 

WP 3: To investigate flight behaviour and orientation of hawk hawk moths in relation to weather and topography using vertically-looking radar, at key migration bottlenecks, high altitude passes in the southern Alps.
Design of an inverted F antenna by using a transmission line model

This paper presents a transmission line model used to design an inverted F antenna (IFA) at the frequency of 2.45 GHz. This model provides a quickly design of a printed F antenna antenna that can be easily integrated into handheld devices or printed on PCMCIA cards for WLAN communications in the ISM band. A simple iterative method which consider inductive or capacitive loadings was adopted to design the antenna in conjunction with a 3D EM simulators obtained a good solutions to design IFA. A prototype of proposed planar inverted F antenna (PIFA) has been manufactured on a FR4 substrate with a bandwidth of 230 MHz in order to demonstrate the reliability of the model validated by the good agreements with the experimental and simulated measurements.
Riboswitch Discovery, Structure and Function

This new volume of Methods in Enzymology continues the legacy of this premier serial with quality chapters authored by leaders in the field. This volume covers research methods in riboswitch discovery and validation, synthesis and sample prep methods for large RNAs, riboswitch structure and function methods, folding pathways and dynamics, and ligand interactions and thermodynamics. * Continues the legacy of this premier serial with quality chapters authored by leaders in the field* Covers research methods in riboswitch discovery, structure and function* Contains sections on such topics as riboswitch discovery and validation, synthesis and sample prep methods for large RNAs, riboswitch structure and function methods, folding pathways and dynamics, ligand interactions and thermodynamics
New insight on the oxidative degradation in materials used by Piero Gilardi in two second generation Nature Carpets: A micro-invasive spectroscopic approach

Abstract Nature Carpets are installations realized by Piero Gilardi using expanded polyurethane, cut, shaped, and painted with vibrant colors in order to portrait natural sceneries. Their intrinsic mixed media nature often exposes them to fast degradation. While it is well known how Nature Carpets are realized using expanded poly(ether urethane), material particularly prone to fast oxidative degradation, the chemical composition of the paint often remains unknown. Furthermore, it has been reported how the artist changed his working technique during the years, in order to increase the life-span of his artworks. Since the paint layer protects the internal expanded foam core, for conservation purposes it is extremely important to know its composition. This study presents analytical results on the materials used in two Nature Carpets: La Grotta (1981, restored in 1989) and Scoglio Sonoro Interattivo (1997), focusing in particular on the paint layer composition. A micro-spectroscopic approach was chosen to obtain as much information as possible from minimal sampling, in order not to damage the artworks.
A Hybrid ACO algorithm for the Next Release Problem

In this paper, we propose a Hybrid Ant Colony Optimization algorithm (HACO) for Next Release Problem (NRP). NRP, a NP-hard problem in requirement engineering, is to balance customer requests, resource constraints, and requirement dependencies by requirement selection. Inspired by the successes of Ant Colony Optimization algorithms (ACO) for solving NP-hard problems, we design our HACO to approximately solve NRP. Similar to traditional ACO algorithms, multiple artificial ants are employed to construct new solutions. During the solution construction phase, both pheromone trails and neighborhood information will be taken to determine the choices of every ant. In addition, a local search (first found hill climbing) is incorporated into HACO to improve the solution quality. Extensively wide experiments on typical NRP test instances show that HACO outperforms the existing algorithms (GRASP and simulated annealing) in terms of both solution quality and running time.
A Critique of Single-issue Campaigning and the Importance of Comprehensive Abolitionist Vegan Advocacy

A popular tactic in the professional nonhuman animal rights movement is to utilize species-specific or issue-specific campaigns to increase public concern, motivate participation and extend movement support. This article challenges this traditional tactic of moderate nonhuman animal organizations in critiquing the issue-specific approaches to abolition advanced elsewhere and calls for a holistic abolitionist method that requires advocates to relinquish confusing piecemeal campaigns and instead challenge the underlying problem of speciesism in order to influence lasting and meaningful social change. The article applies Francione's radical theory of nonhuman animal rights, which recognizes the importance of vegan education in challenging this oppression. This article makes an argument for the role of radical motivation tactics in social movements as instrumental in reaching desired social change goals in a social movement environment that has largely professionalized.
The Killing of Lilian Margaret Burton and Black and White Nationalisms in Northern Rhodesia (Zambia) in the 1960s

The symbolic significance of politically-motivated killings of Europeans during the nationalist struggle against colonial power in Africa in the 1950s and 1960 has long eluded the scrutiny of most historians. For although many historians have demonstrated the ways in which such killings shaped the pace of the decolonisation process in the continent, they have seldom shown how the killings themselves became an important terrain on which competing black and white nationalisms were played out. This article draws on recent academic discourse that places a premium on the political significance of death to explore the ways in which the murder of Lilian Margaret Burton by African activists of the United National Independence Party on the Zambian Copperbelt in 1960 informed rival nationalisms prior to the country's independence in 1964.