SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Correspondencia en torno a de los encargos de las tumbas de los gobernadores franceses de Menorca (1759-1763): transcripción y análisis

Los encargos en 1759 y después en 1762 de tumbas para los gobernadores franceses de Menorca (el marqués de Frémeur y el conde de Lannion), fallecidos en el ejercicio de sus funciones, constituyen hechos microscópicos que revelan cuestiones complejas en las que se entrecruzan ambiciones geopolíticas, condicionamientos económicos y los imperativos de una carrera artística. Estas tumbas son notables no por su tamaño y su forma (se trata de simples lápidas de mármol), sino por el peso de sus inscripciones, que tienen una fuerte carga política. Desde un punto de vista artístico, permiten documentar la carrera de un artista entre Francia y España y la articulación entre actores procedentes de medios académicos diferentes (pintura y escultura frente a literatura). Gracias a la correspondencia conservada en los archivos departamentales de Bocas del Ródano, en Marsella, este artículo desea analizar y dar toda su envergadura a estos diferentes aspectos.
Precision micromechanical lever for next-generation cell culture systems

Instruments to culture cells under confinement conditions are not yet available in the market, yet there is a clear need to culture cells in conditions that most closely mimic in vivo conditions. In particular, such a tool would allow the study of cells in a mechanical environment that resembles the high pressure inside tumours. Based on studies of the market and our designs, we estimate a yearly market of 25 million euros from academic cancer research labs alone. We will further expand these tools for applications in white blood cell maturation and stem cell differentiation.
For this project, we need to hire a researcher capable of designing a high-precision instrument to exert confinement on the cells uniformly without crushing them. The basic design has already been validated, but the current method to exert pressure is unreliable and cannot be commercialized. We do not have the precision instrumentation knowledge in-house to build a better tool and we have been unable to find a suitable candidate in the local market.
We propose to find an associate who is enthusiastic about entrepreneurship, has expertise in precision instrumentation and experience in microfluidics and cell culture. We will train this candidate in entrepreneurship from the perspective of a start-up company and encourage them to start their own spin-off company with the instruments they build. At Elvesys, we have already created two successful spin-off companies.
With these tools, Elvesys will gain an opening in the market of next-generation cell culture tools. We can then establish ourselves as the preferred partners of academic researchers in providing microfluidic solutions to cell culture problems. We will also position ourselves in a pioneering position to become a key player in a strategic sector. Our long-term strategic goal is to develop tools for medical diagnostics, personalized medicine and organ-on-a-chip technologies.
Braquiópodos Carboníferos de la Costa E de Asturias (España). II: Spiriferida y Terebratulida

Este trabajo es la segunda parte de Martínez Chacón, 1990, Revista Española de Paleontología, vol. 5. En él se continúa con la descripción de la fauna de braquiópodos del Carbonífero Medio (Bashkiriense - Moscoviense) de la costa E de Asturias, abordando ahora los Spiriferida (12 géneros, 14 especies), con las nuevas especies Brachythyrina llanisca, Skelidorygma asturica, Phricodothyris (Condrathyris) truyolsae, Spiriferellina multispinosa y Altiplecus antiquus, y el nuevo género de Terebratulida Pelaiella, con la nueva especie P. exigua. Esta fauna tiene pocos elementos en común con otros niveles ele la Cordillera Cantábrica ele la misma edad, como son los paquetes productivos de la Cuenca Carbonífera Central y la Fm. Fito, debido al distinto ambiente ele depósito. Las mayores afinidades con otras áreas geográficas se dan con el NE de Europa, los A lpes Cárnicos, Europa Soviética y los Urales.
Commercialization of open vesicles to fuel downstream reaction networks

Numerous biotechnological processes require Adenosine-5'-triphosphate (ATP) as a form of free energy to drive endergonic reactions. The bottleneck is that after some time the reaction stops due to adenosine diphosphate (ADP) build up and the depletion of energy reserves. In living cells, functional and sustainable out-of-equilibrium networks exist. Scientists have tried to mimic such autonomous systems without the need for external interaction, or fuel supply. Real success hasn’t been reported.   We managed to construct a fuel system in synthetic vesicles that is kept away from equilibrium by controlling the energy dissipation. These vesicles are power houses for sustainable production of ATP (and removal of ADP) much like mitochondria power the ATP-demanding reactions in the cytosol of a cell. In further tests, we were able to reach an order of magnitude longer autonomous operation of a real-life application making our approach truly unique. All the comparable approaches focus on feeding the reaction with ATP without draining of the ADP. Our system creates the fuel from an amino acid while the ATP/ADP ratio is kept constant. The gain for applications is evident; the reactions, and therefore systems, can operate autonomously for long periods of time. This is particularly important for mobile systems with limited supply of reaction materials and where user intervention has to be minimal. Therefore, we expect to enable a completely new generation of autonomous biotech and chemistry applications, such as targeted drug delivery, analytics of nucleic acids or proteins, and cascade reactions for (bio)chemical syntheses of antibiotics, vitamins and other complex molecules.  In this PoC, we will advance the commercialization of our approach by carrying out a technical feasibility for sustainable production of ATP for long-lasting sequencing of DNA application. In addition, we will prepare a commercialization plan, carry out partnering actions and strengthen the IP further.
SULFUR TRIOXIDE DECOMPOSITION CATALYST, SULFUR DIOXIDE PRODUCTION PROCESS USING SULFUR TRIOXIDE DECOMPOSITION CATALYST, HYDROGEN PRODUCTION PROCESS USING SULFUR DIOXIDE PRODUCTION PROCESS, AND PROCESS FOR PRODUCING SULFUR TRIOXIDE DECOMPOSITION CATALYST

A sulfur trioxide decomposition catalyst includes: a composite oxide containing an alkali metal and vanadium; and a catalyst support on which the composite oxide is supported. In addition, a process for producing a sulfur trioxide decomposition catalyst includes: impregnating the catalyst support with one solution of a solution containing an alkali metal compound and a solution containing a vanadium compound, and drying and preliminarily calcining the catalyst support; and impregnating the preliminarily calcined catalyst support with the other solution of the solution containing the alkali metal compound and the solution containing the vanadium compound, and drying and calcining the catalyst support.
Investigation of CYP2D6 Gene Polymorphisms in Turkish Population.

Pharmacogenetics is interested in the variable response to drugs depending on the genetic constitution of an individual. Depending on the genetic variation in individuals known as polymorphism; leads to differences in the types of proteins, enzymes or receptors that play a role in the elimination of drugs. Investigation of the correlation between the genotype with phenotype changes in drug metabolism is among the most important topics of today. CYP2D6 gene polymorphisms show clinical efficiency in the use of especially antidepressants, neuroleptics, antiarrhythmic, antihypertensive, beta blocker, and morphine derivatives. Poor metabolizers have been shown to demonstrate adverse drug reactions to these drugs. The plasma concentrations tend to increase inducing side effects after using a standard dose in poor metabolizers. The ratio of poor metabolizers in Caucasians is 5-10%, whereas 3.4-3.8% of the Turkish population. The allele frequencies of CYP2D6 *2, *3, *4 and *10 were found in 35%, 6%, 10% and 26% respectively in 200 healthy controls. The ratio of poor metabolizers in our population revealed as 1%. Genotyping of CYP2D6 is very important for determining a better genotype-phenotype relation.
Development and promotion of Mediterranean Sustainable Adventure Tourism

The Mediterranean region is one of the world’s leading tourist destinations. Facing growing competition and deterioration of the political and security situation, the destination has demonstrated symptoms of a slowdown, which makes the recovery of the sector an economic priority. This downturn may also present an opportunity to transform the tourism model into a sustainable and competitive one, addressing current sectorial challenges as the predominance of mass seaside tourism, dependent on the European market and territorial imbalances. MEDUSA will tackle these joint challenges via targeted and inter-related capacity building and cross-border interventions to develop and promote adventure tourism in the region, a niche which grew by 195% between 2010 and 









2014. By designing and testing routes and itineraries that offer improved adventure tourism products, MEDUSA will contribute to job creation and income for local communities in the medium and long term. Moreover, the project has the potential to reveal lesser-known destinations and attract tourists throughout the year.
Jr International Fairs 2019-2022 — PGP INDE, d.o.o.

Individual appearance at the international fair Lineapelle INTERNATIONAL EXHIBITION OF LEATHER, Accessories, COMPONENTS, Fabrics, Synthetics AND MODELS. from 19.2.2020 to 21.2.2020
COMPANY CONSOLIDATION PLAN WITH INCLUSION OF NEW PRODUCTION TECHNOLOGIES USEFUL TO OFFER A COMPLETE SERVICE TO THE FURNITURE MARKET (DESIGN, DEVELOPMENT, REALISATION AND ASSEMBLY OF FURNISHING SOLUTIONS)

STEFANO COLOMBO SRL IS A COMPANY SPECIALISED IN THE MANAGEMENT OF FURNISHING ORDERS. IN THE COURSE OF ITS EVOLUTION IT IS FIRST SPECIALISED IN THE ACTIVITY ON BEHALF OF THIRD PARTIES OF ASSEMBLY AND INSTALLATION FURNITURE AND THEN START A BRANCH OF COMPANY DEDICATED TO THE DESIGN AND REALISATION OF INDIVIDUAL COMPONENTS. THE ENTREPRENEURIAL INITIATIVE AIMS TO DIVERSIFY AND COMPLETE THE CUSTOMER SERVICE, INCREASING THE COMPETITIVENESS OF THE STRUCTURE THROUGH USEFUL INVESTMENTS TO ALLOW THE INTERNAL REALISATION OF ALL TYPES OF WOODEN ARTIFACTS FOR FURNISHING. IT IS THEREFORE INTENDED TO MOVE FROM CONTRACTORS COMMISSIONED TO THE ASSEMBLY OF FURNITURE MADE BY OTHER COMPANIES (CARPENTERS, FURNITURE INDUSTRIES) TO REAL DESIGNERS AND DESIGNERS OF FURNITURE ABLE TO PROVIDE THE CUSTOMER WITH A COMPLETE SERVICE. IN PARTICULAR, IT IS INTENDED TO CREATE A PRODUCTION DEPARTMENT DEDICATED TO SAMPLES/PROTOTYPES TOGETHER WITH THE INCREASE OF THE OPERATING CAPACITY MED
Global climate change impact on phenotype and epigenome stability:  accessing plant adaptability through a 2050 simulation model

One of the key challenges in the 21st century will be food security. Computer modelling using historical data predicts a climate shift towards combination of increasing temperature, rising carbon dioxide (CO2) levels and high Ultraviolet (UV) radiation. Such climatic change could negatively affect productivity of the agricultural systems and thus availability of food for the growing world’s population, which is a very serious concern. However, most of the current debate is based on little experimental evidence. Therefore, we aim to address this question by establishing a strong backbone of phenotypic and molecular data in the frame of the proposed project. Our first objective will be to examine the impact of the predicted 2050 climate on the morphological and physiological performance of the model and the crop plants. Adaptation of plants to environmental cues occurs also at the gene transcriptional level and is widely controlled by epigenetic means. Therefore, in the second objective we will study plant chromatin changes in response to predicted climatic change and their effects on plant phenotypes. Our study will act as a resource to framework the phenotypic and molecular mechanism by which these environmental variations affect crop yields and current estimates of future impacts of climate. Hence, the longer term goal of the project is to contribute towards solving the current food security issues by providing valuable resource of data for scientists along with the strategy makers.
Reliability Analysis of Bridge under Multi Adverse Factors

A bridge is a structure built to span physical obstacles such as a body of water, valley, or road, for the purpose of providing passage over the obstacle. As critical transportation junction in the transportation network, bridge controls the traffic capacity of the transportation network. In the past decade, collapse of highway bridges caused by natural hazard and human error occur frequently. There are three main reason of collapse: 1) overloading; 2) construction deficiency; 3) imbalance of the system safety. In this paper, a collapsed bridge in Harbin is studied based on probability. A reliability analysis is conducted to investigate the system safety of the case bridge under combined effect of overloading and construction deficiency. Some suggestions for bridge quality control are proposed.
Framework initiative fostering the sustainable development of Adriatic small ports

FRAMESPORT project will perform a coordinated initiative supporting an integrated and sustainable development of small ports in a strategic perspective, thus allowing them to be pro-active socio-economic drivers of the development in the Adriatic coasts. Such a strategic objective calls for a multifaceted approach, including both the adoption of concrete pilot actions as well as identification of priority themes to be promoted within the overall strategy. Priorities will be individuated by means of a bottom-up approach, involving local and national stakeholders since the project inception phase. Partners, which has been chosen in order to guarantee a wide territorial approach, will address planning and management topics, business models implementation, enhancement of training and competence, as well as develop ICT tools and services, thus supporting an effective development of small ports in the whole IT-HR area. Furthermore, a tailor-made ICT platform will collect and systematize relevant key data on small ports to be shared as starting point of any further development. FRAMESPORT will build on existing knowledge and capitalize results of pilot initiatives by integrating them in a new strategic framework boosting small-scale maritime nodes performances along the Adriatic coasts.
Flows unveiled: multimodal measurement in opaque two-phase flows

Dispersed multiphase flows are encountered in nearly every process in nature and industry; examples include sediment in rivers, catalysts in reactors and blood flow. Despite their relevance, it is currently difficult to accurately and efficiently model these flows. The opacity of the flows, even at moderate volume fractions, renders the common optical flow measurement tools useless. As a result, very little high-quality data is currently available to develop (numerical) models.

In this project, I lift the veil that covers multiphase flows. I do this by bringing together four flow measurement modalities, based on ultrasound, magnetic resonance, X-ray and advanced optical imaging. These are each applied to three benchmark flows, impenetrable to common (optical) techniques. This project will be the first focused effort to systematically apply these techniques to the same three benchmark flows. These benchmarks are: (1) a turbulent flow with heavy particles, (2) a laminar flow with relatively large particles and (3) a laminar flow with small particles showing non-Newtonian behaviour. These three flows represent archetypical flows from nature and industry, each pertaining to particular open questions in the field of fluid mechanics. The combined velocity and concentration field data resulting from this set of experiments will be vital in assessing and improving each of the techniques: direct comparison will allow evaluation of the performance and show the effect of acquisition and processing parameters on the accuracy. Detailed simulations using the exact same conditions will serve as further reference. Combined with the multi-modal experimental data, this will give breakthrough insight in the underlying physics of each of the benchmark flows. This in turn will lead to better multiphase flow models, which are demanded by a wide range of application areas (e.g. process technology, dredging, food and cosmetics industry, and hemodynamics research).
Characteristics of Wood Fuel Pellet Manufacturers and Markets in the United States, 2010

The wood fuel pellet industry has been growing rapidly in recent years. The survey results reported here are focused on the annual production, raw material, production cost rankings, market radius, barriers to market expansion, and other data that give an overview of the industry during a very difficult economic period. Eighty-four mills across the United States were contacted and 53 responded. The average volume of production was over 59,000 tons per year. Raw materials for pelletizing and labor were the principal costs of production according to respondents. Market demand and capital costs were cited as the chief barriers to expansion. The industry is clearly subject to market forces that influence the cost and availability of raw materials as well as the cost of heating fuel alternatives such as oil. Despite the economic difficulties, demand continues to grow for pellet fuels both in the United States and in Europe.
Load balancing virtual machines deployment mechanism in SDN open cloud platform

As a cloud data center may be located over many regions and the network environment within a cloud data center may differ from traditional ones, how Virtual Machines (VMs) are deployed will influence service performance. This study, based on the Eucalyptus cloud computing and Software-Defined Networking platform, proposes a load balancing scheduling mechanism that works on the current network status between users and associated VMs to improve the cloud services. This study also set up a node controller on the same subnet and different subnet. Study results indicate that in the same subnet of normal network, the VMs deployed with the proposed mechanism improve transmission time by 2.64% and 68.72% compared to that of the Round Robin and Greedy mechanisms consecutively. In the different subnet of normal network scenario, the proposed mechanism improves transmission time by 22.01% and 52.11% compared to that of the Round Robin and Greedy mechanisms respectively.
Data-Driven decision-support to increase energy efficiency through renovation in european building stock.

While EU policy assigns a primary role to Energy Efficiency (EE), the lack of a holistic understanding of the impact of EE investments has hindered its integration in the policy-making process. Coordination between demand and supply side of energy policy is not targeted, and there is need to gather the evidence on the benefits of EE in ecological and socio-economic terms as well as on its interactions with the broader policy context and energy market. The EERAdata project aims to address this challenge by supporting policy decisions and related stakeholders with an organic set of instruments to prioritise investments in energy efficiency in the context of the European building stock and its potential for renovation.

The EERAdata project will develop and test a decision-support tool to help local administrations in the collection and processing of their building and demographic data towards an assessment and prioritization of EE measures in planning, renovating and constructing buildings. The tool will be operationalized through a software application capable of merging data from various sources, formats and fields, which will then model and assess the impact of energy efficiency investment in buildings across several categories of impact, and against a range of supply-side measures.

Partner municipalities will participate to the design of the tool and test its application in regional pilots. The pilots will be part of a wider process of stakeholder engagement aimed at ensuring the usefulness of the different instruments, their applicability across different geographical and economic contexts, and its adoption beyond the life-span of the project. To this end, the project team will establish regional networks of stakeholders centred around the partner municipalities. These networks will be engaged throughout the project to bridge the gap between demand- and supply-side of energy policy.
The 2022 report of the Lancet Countdown on health and climate change: health at the mercy of fossil fuels

The 2022 report of the Lancet Countdown is published as the world confronts profound and concurrent systemic shocks. Countries and health systems continue to contend with the health, social, and economic impacts of the COVID-19 pandemic, while Russia's invasion of Ukraine and a persistent fossil fuel overdependence has pushed the world into global energy and cost-of-living crises. As these crises unfold, climate change escalates unabated. Its worsening impacts are increasingly affecting the foundations of human health and wellbeing, exacerbating the vulnerability of the world's populations to concurrent health threats.
Asperity level tribological investigation of automotive bore material and coatings

Choosing in-cylinder surfaces is complex. A well-chosen surface has low friction and wear. Conversely, poor oversight often leads to premature failure through wear and scuffing. Typically cylinder bore surfaces are selected experientially. This paper demonstrates the use of Atomic Force Microscopy in LFM mode, characterising typical cylinder bore materials and coatings. The approach uses integrated LFM with continuum contact mechanics. It evaluates the real contact area and effective elastic modulus of the surface, including the effect of any reactive surface film. Surface energy and shear strength, as well as the coefficient of friction in nanoscale interactions are also determined. These properties are measured for 6 cylinder bore materials, including for composite Nickel-Silicon Carbide and DLC, used for high performance engines.
Mycobacterium tuberculosis employs Cpn60.2 as an adhesin that binds CD43 on the macrophage surface

CD43 is a large sialylated glycoprotein found on the surface of haematopoietic cells and has been previously shown to be necessary for efficient macrophage binding and immunological responsiveness to Mycobacterium tuberculosis. Using capsular material from M. tuberculosis and recombinant CD43-Fc, we have employed affinity chromatography to show that Cpn60.2 (Hsp65, GroEL), and to a lesser extent DnaK (Hsp70), bind to CD43. Competitive inhibition using recombinant protein and polyclonal F(ab')(2) antibody-mediated epitope masking studies were used to evaluate M. tuberculosis binding to CD43(+/+) versus CD43(-/-) macrophages. Results showed that Cpn60.2, but not DnaK, acts as a CD43-dependent mycobacterial adhesin for macrophage binding. Assessment of the specific binding between Cpn60.2 and CD43 showed it to be saturable, with a comparatively weak affinity in the low micromolar range. We have also shown that the ability of Cpn60.2 to competitively inhibit M. tuberculosis binding to macrophages is shared by the Escherichia coli homologue, GroEL, but not by the mouse and human Hsp60 homologues. These findings add to a growing field of research that implicates molecular chaperones as having extracellular functions, including bacterial adherence to host cells. Thus, CD43 may act as a Pattern Recognition Receptor (PRR) for bacterial homologues of the 60 kDa molecular chaperone.