SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Translating fundamental insights in endothelial metabolism: pfkfb3 drug discovery and development

Angiogenesis, the growth of new blood vessels, contributes to major pathologies such as blinding ocular disease, inflammation and cancer. Blocking angiogenesis has therefore become a major field of research and an attractive therapeutic strategy. Current anti-angiogenic therapies focus on blockade of pro-angiogenic factors, such as VEGF. However, in cancer, insufficient efficacy, resistance and toxicity restrict the success of anti-VEGF agents. There is thus an urgent unmet need for novel anti-angiogenic strategies. In our ERC Advanced research grant (ECMetabolism), we developed an entirely novel anti-angiogenic concept and strategy, based on targeting key metabolic pathways in endothelial cells (ECs), cells lining blood vessels. More in particular, we identified - for the first time - that PFKFB3, a key glycolytic regulator, as a novel and promising target for anti-angiogenic therapy. Our findings show that glucose metabolism determines vessel sprouting and that lowering glycolysis only partially and transiently (by blocking PFKFB3) sufficed to inhibit pathological angiogenesis without causing systemic effects. In this ERC proof of concept project, PFKFBLOCK, we aim to develop lead small molecule compounds, blocking PFKFB3, and evaluate their potential to block pathological angiogenesis. Currently, no specific and orally available PFKFB3 blocker exists underscoring the value of our proposal and the necessity to develop such blocker for therapeutic applications. Through collaboration with a drug discovery unit we will identify lead molecules with novel intellectual property potential. Those lead compounds will be validated in relevant in vivo models and considered to be patented. The ultimate goal of this project is to get the best PFKFB3 inhibitor in clinical trials.
METHOD FOR SYNTHESISING A COPOLYMER OF ETHYLENE AND 1,3-DIENE

The invention relates to a method for producing a copolymer of ethylene and a 1,3-diene of formula CH2=CR-CH=CH2, R being a hydrocarbon chain having between 3 and 20 carbon atoms, the ethylene units in the copolymer representing between 50 mol % and 95 mol % of the ethylene units and the units of the 1,3-diene present in the copolymer, and the units of the 1,3-diene with a 1,2 and 3,4 configuration in the copolymer representing more than 50 mol % of the units of the 1,3-diene present in the copolymer, said method comprising the polymerisation of ethylene and of the 1,3-diene in a reactor in the presence of a catalytic system at least containing one metallocene and one organomagnesium compound, ethylene and 1,3-diene being continuously added into the reactor during the polymerisation.
Novel eosc services for emerging atmosphere, underwater and space challenges

NEANIAS is an ambitious project that comprehensively addresses the ‘Prototyping New Innovative Services’ challenge set out in the recent ‘Roadmap for EOSC’ foreseen actions. NEANIAS will drive the co-design, delivery, and integration into EOSC of innovative thematic services, derived from state-of-the-art research assets and practices in three major sectors: underwater research, atmospheric research and space research.  Each of these sectors engages a diverse set of research and business groups, practices, and technologies. Each thematic service will not only address its community-specific needs but will also enable the transition of the respective community to the EOSC concept and Open Science principles. In doing so, NEANIAS provides its communities with plentiful resource access, collaboration instruments, and interdisciplinary research mechanisms, which will amplify and broaden each community’s research and knowledge generation activities. From a technological perspective, NEANIAS will deliver a rich set of services that are designed to be flexible and extensible; they will be able to accommodate the needs of communities beyond their original definition and to adapt to neighboring cases, fostering reproducibility and re-usability.  From a sustainability perspective, NEANIAS identifies promising, cutting-edge business cases across several user communities and lays out several concrete exploitation opportunities.
Evaluation of market samples of ′Yashada bhasma′ using ′Namburi Phased Spot Test′

Yashada bhasma (Calx of Yashada i.e. Zinc) which has its main indication in Prameha (Diabetes) and Netra vikaras (Eye disorders) was prepared according to the prescription in the Ayurvedic classics and subjected to various bhasma parikshas, including the Namburi Phased Spot Test (NPST), one of the qualitative tests described for various Ayurvedic preparations. NPST helps differentiate between, and thus identify, various bhasmas. It depends upon the pattern of the spot, which develops after a specific chemical reaction. Three market samples of Yashada bhasma, which were said to be Parada marita (incinerated using Mercury), were also subjected to the above tests and results compared. The various bhasmas exhibited marked differences in colour, and though NPST yielded desired results for all the samples, there were differences in their spot patterns and colour. The bhasma prepared in our department produced the most accurate results.
Interference with acute nausea and anticipatory nausea in rats by fatty acid amide hydrolase (FAAH) inhibition through a PPARα and CB1 receptor mechanism, respectively: a double dissociation

Fatty acid amide hydrolase (FAAH) inhibition elevates anandamide (AEA), which acts on cannabinoid (CB1 and CB2) receptors, as well as N-palmitoylethanolamide (PEA) and N-oleoylethanolamine (OEA), which act on peroxisome proliferator-activated receptor alpha (PPARα). Here, we determine the mechanism of action of FAAH inhibition on acute and anticipatory nausea (AN).We compared the effectiveness and mechanism of action of two FAAH inhibitors, URB597 and PF-3845, to reduce acute nausea and AN in rodent models of conditioned gaping.For assessment of acute nausea, rats were pretreated with vehicle (VEH), URB597 (0.3 and 10 mg/kg, experiment 1a) or PF-3845 (10 mg/kg, experiment 1b) 120 min prior to a saccharin-lithium chloride (LiCl) pairing. To assess the CB1 receptor or PPARα mediation of the effect of PF-3845 on acute nausea, rats were also pretreated with rimonabant or MK886, respectively. For assessment of AN, following four pairings of a novel context with LiCl, rats received a pretreatment of VEH, URB597 (0.3 mg/kg, experiment 2a), or PF-3845 (10, 20 mg/kg, experiment 2b) 120 min prior to placement in the AN context. To assess the CB1 receptor or PPARα mediation of the effect, rats were also pretreated with rimonabant or MK886, respectively.PF-3845 (10 mg/kg, but not URB597 0.3 or 10 mg/kg) suppressed acute nausea via PPARα, but not CB1 receptors. URB597 (0.3 and 10 mg/kg) or PF-3845 (10 and 20 mg/kg) reduced AN via CB1 receptors, but not PPARα.FAAH inhibition reduces acute nausea and AN through PPARα and CB1 receptor mediated effects, respectively.
Research on the Formation Mechanism and Dynamic Factors of Commercial Housing Prices Based on the Correction Carey Model - Panel Data from Thirty-Five Key Cities

Since 2004, a nationwide commercial housing prices showing explosive growth, This paper use the Carey model studying the volatility of commodity housing price mechanism theory. By Carey theoretical correction model in 1998-2003 and 2004-2010, respectively, in two stages to establish the individual fixed effects and individual random effects panel data model focused on the monitoring of the Ministry of Construction of the 35 cities of the empirical testing of commercial housing price. Analysis concluded that the cost of land, building costs, per capita disposable income of urban residents, urban population, and psychological expectations is the main factors to promote China's real estate prices.
METHOD AND SYSTEM FOR DETECTING FAULT-INDUCING CLIENT USING FAULT-CORRESPONDING EDGE SERVER GROUPING

Provided is a client terminal access control method, and the method includes: allocating a communication process of a first client group comprising a plurality of client terminals to an edge server; when a failure occurs in an operation of the edge server, allocating a communication process of a second client group comprising at least one client terminal belonging to the first client group to a failure-handling edge server; and determining whether a failure occurs in an operation of the failure-handling edge serve.
Metabolism analysis made easy for cell translational medicine

The healthcare industry is experiencing unprecedented rates of drug failure, long development times and high costs - because current lab tests and disease models (in vitro) don’t adequately predict drug effect in the patient (in vivo). 

To address this “Challenge”, three leading EU SMEs; Luxcel Biosciences Ltd, Axiogenesis AG and BMG Labtech GmbH, are partnering to bring to market, a fully integrated targeted metabolomics Test Platform, comprising physiologically relevant in vitro cell assays and easy to use test kits, configured for use with the multimode fluorescence plate reader; instrumentation, which is installed in, or else is easily accessible to every cell biology lab globally. 

The innovation “Solution"" is made possible by Luxcel’s unique and patented optical nanosensor technology, and its integration to create entirely new ‘functionally-connected’ in vitro tests. The scope of the project is to finalize development of the cell-based assay platform towards market introduction, productise, pilot and demonstrate it with key opinion leaders; for modular product launch through the project and full launch early 2019. 

Leveraging existing global sales channels, the three industrial partners are targeting revenues of EUR 15 million by 2023.  In total, about 24-29 new jobs will be created by 2023; with 6 new jobs during the project. All three SMEs are passionate about the MetaCell-TM solution, and expect that a successful outcome will see them positioned as No. 1 in their respective fields in Europe and internationally.
Scientists and engineers for the quantum world

Quantum technologies (QT) are at the brink of revolutionising the world in many areas of our everyday lives. With parallels to the replacement of analogue with digital electronics in the late 20th Century, quantum devices will supersede digital in the future, leading to dramatic improvements in the capabilities of key technologies and industries. These include gravimeters (earth observation; military; prospecting), atomic clocks (satellite-free navigation; finance) and computing/secure communications (banking; military). Having played a vital role in shaping the global scientific QT landscape for the last 10 years, M Squared Lasers (MSL) is well placed to lead commercial developments at the heart of a European QT supply chain. Building on a track record of translating novel science into demanding markets, MSL will develop QT components, subsystems and integrated devices that will enable a wide range of applications. Starting with components and subsystem development (in line with the EU Quantum Manifesto), MSL will become increasingly vertically integrated as the QT initiative progresses. MSL have developed a first iteration magneto-optical trap that is ready to be developed into a stable atom interferometer and to conduct gravity measurements. With this project MSL aim to develop an innovation programme on the commercialisation of a gravimeter. To realise these goals MSL needs to recruit a high calibre engineer who has first hand experience in developing quantum technologies and in depth knowledge of cold atom physics and quantum mechanics. MSL has found it hard to recruit the necessary niche specialist skills in quantum technology development required. To meet this innovation opportunity MSL needs to overcome barriers to recruitment by widening its recruitment pool from UK to EU and increasing visibility. This project provides the framework to overcome these barriers and deliver the envisaged project results and impacts.
Causal relationship between macro-economic indicators and stock exchange prices in Pakistan

Stock market plays an important role in the economic development of a country. A number of studies have been investigated on the causal relationship between macro-economic indicators and stock exchange prices. But in the context of Pakistan, not many studies can be traced in literature, moreover this study has used the set of macro-economic indicators which has not been previously used by researchers in Pakistan. It has examined the causal relationship between macro-economic indicators and stock market prices in Pakistan. The data from June 1990 to December 2008 have been used to analyze the causal relationship between various macro-economic variables and stock exchange prices. The set of macro-economic indicators includes; inflation, exchange rate, balances of trade and index of industrial production, whereas the stock exchange prices have been represented by the general price index of the Karachi Stock Exchange, which is the largest stock exchange in Pakistan. The statistical techniques used include unit root Augmented Dickey Fuller test, Johansen’s co-integration and Granger’s causality test. The study found co-integration between industrial production index and stock exchange prices. However, no causal relationship was found between macro-economic indicators and stock exchange prices in Pakistan. Which means performance of macro-economic indicators cannot be used to predict stock prices; moreover stock prices in Pakistan do not reflect the macro-economiccondition of the country.

	 

	 Key words: Macro-economic indicators, causality, exchange rate, index of industrial production, inflation, money supply, Pakistan.
Handwritten word spotting by inexact matching of grapheme graphs

This paper presents a graph-based word spotting for handwritten documents. Contrary to most word spotting techniques, which use statistical representations, we propose a structural representation suitable to be robust to the inherent deformations of handwriting. Attributed graphs are constructed using a part-based approach. Graphemes extracted from shape convexities are used as stable units of handwriting, and are associated to graph nodes. Then, spatial relations between them determine graph edges. Spotting is defined in terms of an error-tolerant graph matching using bipartite-graph matching algorithm. To make the method usable in large datasets, a graph indexing approach that makes use of binary embeddings is used as preprocessing. Historical documents are used as experimental framework. The approach is comparable to statistical ones in terms of time and memory requirements, especially when dealing with large document collections.
Impact of Race on Graft-Versus-Host Disease Rates after HLA-Matched Sibling Bone Marrow or Peripheral Blood Hematopoietic Cell Transplantation: Comparison of North American Caucasian Versus Japanese Populations

s / Biol Blood Marrow Transplant 21 (2015) S30eS53 S35 grade 3-4 aGVHD post PBSC alloHCT was 14% and 10% in the Caucasians and Japanese, respectively (Figure 1B). In multivariate analysis, the interaction term between race and graft source was not significant in any of the models, indicating that the impact of race on outcomes does not differ according to graft source. The risk of grade 3-4 aGVHD was significantly lower in Japanese compared to Caucasians (HR 0.74, 95% CI 0.57-0.96), which resulted in lower risk of non-relapse mortality (NRM) in Japanese compared to Caucasian patients (HR 0.69, 95% CI 0.54-0.89). The risk of relapse was also lower in Japanese compared to Caucasian patients (HR 0.75, 95% CI 0.63-0.89). Lower risk of NRM and relapse resulted in lower overall mortality rates in Japanese compared to Caucasians (HR 0.70, 95% CI 0.59-0.83). The risk of grade 3-4 aGVHD was significantly higher in PBSC compared to BM alloHCT recipients (HR 1.63, 95% CI 1.202.20), which resulted in higher NRM (HR 1.31, 95% CI 1.041.65) in PBSC compared to BM alloHCT recipients. Conclusions: Irrespective of graft source, the risk of severe aGVHDwas lower in Japanese patients, which resulted in the lower risk of NRM. The risk of severe aGVHD was higher in the PBSC alloHCT recipients, which resulted in the higher risk of NRM.
Diffusion of renewable energy technologies (RET) research: past, present and future

Many RET projects fail to achieve continuity, replication, commercialization and sustainable markets even when pilot projects demonstrate high potential and great interest from the potential users. Many RET diffusion studies try to explain the dynamics of the diffusion process and provide answers as to why successful demonstration and high consumer interest do not metamorphose into viable and sustainable RET commercialization. A tendency to focus on specific technologies in precise geographical locations creates a wide variation in RET diffusion studies (Nagamatsu et al, 2006). However, deeper analysis of the variations reveals many common issues in methodology, findings, conclusions and recommendations that can be generalised to RET diffusion. By reviewing published papers on diffusion of RET published between before 2013, this paper attempts to identify general patterns in RET diffusion studies, which can be used worldwide in the process of increasing the uptake of renewable energy technologies by trying to map out in a quite comprehensive manner what has been done and studied in this field over the last two decades in a more general fashion.
Standardised approaches and products for the systemic retrofit of residential buildings, focusing on heating and cooling consumptions attenuation.

Heating consumption in the residential sector in Europe is around 2300 TWh/y, DHW consumptions reaches 500 TWh/y, while cooling consumption is less than 100 TWh/y. The construction sector offers unique opportunities to decarbonise the European economy. However, as the replacement rate of the existing stock is very small (1-1.5 % per year), acceleration is needed.
On top of this, the reorganisation of the sector poses tremendous challenges due to its extreme fragmentation: more than 50% of the residential buildings are owned by private single owners. Moreover, whilst few major industrial players are active on the market, it is largely dominated (more than 95%) by SMEs both on the manufacturers’ and the professionals’ side.
BuildHEAT addresses this challenging sector by:
- elaborating systemic packages for the deep rehabilitation of residential buildings
- developing innovative technologies facilitating the implementation of the renovation measures
- developing financial tools enabling large public and private investments 
- involving the construction chain from the very beginning and all along the building life cycle.
A set of reliable, energy efficient and affordable retrofit solutions will be mad available, which execution is facilitated by industrialised, modular and flexible HVAC, façade and ICT systems developed.
Despite the affordability, innovative solutions are more expensive compared to off the shelf ones. Therefore financing models are needed to facilitate the massive entry to market of the new technologies. BuildHEAT aims to leverage large private investments by using European structural funds, thus promoting retrofit actions at quarter level.
Finally, BuildHEAT involves the entire construction chain – from owners to professionals to investors – in the retrofit process and all along the lifetime of the building, by addressing technical, behavioural, cultural and economic perspectives. In this way, awareness and involvement are triggered.
Green and Intermodal solutions for Adriatic airports and ports

The main objective of ADRIGREEN project is to improve the integration of Croatian and Italian ports and airports with other modes of transportation in order to enhance the processing of passengers during the summer seasons and to improve environmental performances of the Adriatic maritime and aviation systems. The objective of the testing phase will be to demonstrate the feasibility, the effectiveness and the replicability of the identified solutions. International investigation on best solutions to be transferred on Adriatic coasts will be realized. Furthermore, the project includes the environmental assessments of involved ports and airports, technical manual on identified practices, Cross-Border Forum of Green and Intermodal Ports and Airports to present solutions.
Jr CzK 2022 — HISHKA

HISHKA è un progetto circolare e sostenibile, una soluzione concettuale, un sistema, un marchio, una babysitter basata sui principi del rispetto per gli esseri umani, ARTICOLO e NARAVA.HISHKA* Il nome HISHKA deriva dalla stanza diminutiva slovena per una casa — una casa, una piccola casa.Simbolizza la casa, l'ambiente in cui ci sentiamo sicuri, confortevoli e accettati; un tetto sotto il quale c'è un ampio spazio per l'immaginazione, le idee creative e la ricerca. Uno spazio che è piccolo ma onesto e sostanziale e permette tutto. Offre anche potenziale naturale e potenziale di crescita, potenziando su scala più ampia. Hishka deriva dal sanscrito, dove originariamente significa Aiutare la natura, "Happiness toother".HISHKA risponde alle sfide sostenibili, etiche e creative della moda moderna su diversi livelli: una firma di design potente e riconoscibile in collaborazione con nomi di design espertiattualizza e modernizza l'uso e l'uso di abbigliamento usato, materiali di scarto e nomi usati aggiunge grande valore, implementa i principi sostenibili del riciclaggio, del riciclaggio, del design circolare, il tutto con una forte enfasi sull'arte e sulla moda contemporanea. Allo stesso tempo, il modello di business ricercato, dove gli abiti usati si distinguono in sostanza ed esteticamente uguali a nuovi pezzi.Il progetto HISHKA crea un nuovo modo di comprendere, consumare e vendere la moda che integra la filosofia del rispetto per l'uomo, l'arte e la natura in modo olistico. È un ibrido tra progettazione, riprogettazione e vendita di abbigliamento usato.
Innovative running gear solutions for new dependable, sustainable, intelligent and comfortable rail vehicles

The RUN2RAIL project will explore an ensemble of technical developments for future running gear, looking into ways to design trains that are more reliable, lighter, less damaging to the track, more comfortable and less noisy. These innovations will be proposed in the form of case studies supported by the methods and tools elaborated in the project.

The project develops across four thematic Work Streams: Innovative sensors & condition monitoring, Optimised materials & manufacturing technologies, Active suspensions & mechatronics, Noise & Vibration. In these four areas, the project will provide a coordinated set of technical key contributions including (but not limited to):

- smart sensors and smart running gear components with self-diagnosing capability;
- use of novel materials and manufacturing methods in combination with intelligent / active suspensions to enable non- conventional running gear concepts;
- identification of efficient fabrication processes for the running gear (3D metal printing, automated tape layering of composite  materials);
- assessment of existing off-the-shelf technology for active control coming from other sectors; development of a novel and comprehensive methodology for predicting the transmission of noise and vibration from the running gear to the carbody.

Within the four workstreams, the project will also perform a preliminary evaluation of the related regulatory and standardisation issues, together with a careful assessment of the impacts of the new solutions proposed. The research conducted will be multidisciplinary, i.e. based on the integration of different branches of engineering such as mechanical, materials, electronic and electrical engineering, and will establish models and formal methods to explore a full set of technological developments, exploiting at best the matching mix of talent and diverse skills offered by the Consortium.