SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Concept and feasibility assessment for anandacor, a fast melting tablet, as a diagnostic device in ischemic heart conditions.

Ananda Pharma GmbH qualified a plant derived active pharmaceutical ingredient (API) for specific heart diseases. In nanomolar doses the substance protects cardiomyocytes by stabilizing the Na+/K+ -ATPase. The API enables ischemic preconditioning and has a balancing effect on the energy metabolism of cardiomyocytes by enhancing the turnover of lactate to ATP. The specific mode of action conveys a larger therapeutic range which means a smaller risk for unwanted side effects compared to similar substances.

The API targets mainly on the small vessels and the myocardial cell, rather than on the large vessels, and therefore can be useful to distinguish between relevant obstructive coronary atherosclerosis and the actual ischemia in the microvasculature or in the myocardial cell itself. These properties convey the great potential as a new diagnostic medical device for patients with angina pectoris due to ischemic heart conditions. 

Therefore Ananda Pharma GmbH developed AnandaCor®, an innovative tablet formulation of the active pharmaceutical ingredient.
Since cardiovascular and ischemic heart conditions are highly prevalent in all industrialized countries, with over 2 million deaths per year and estimated external costs of nearly 110 billion € per annum in the European Union alone, there is an urgent need for effective diagnostic investigation.
Structural and electronic transitions of crystalline 2,2′-iminobis (acetamide oxime) induced by different pressure

In this paper, the structural, electronic and absorption properties of 2,2′-iminobis (acetamide oxime) (IBO) under pressure of 0–300[Formula: see text]GPa are calculated by the density functional theory (DFT) calculations. Analysis of the variation trend of lattice constant, bond length and bond angle of IBO under compression conditions, shows there are complex transformations under different pressure. In addition, it is found that the structure of IBO in the [Formula: see text]-axis is stiffer than that along the [Formula: see text]- and [Formula: see text]-axes, which indicates that the crystal has anisotropic compressibility. By analyzing the band structure and the density of states of IBO, it is seen that at 120[Formula: see text]GPa, the electronic structure of IBO changes into metallic system, and becomes more sensitive under compression conditions. The transition between metal and semiconductor occurs again at 150[Formula: see text]Gpa. Finally, at 180[Formula: see text]GPa, the crystal transforms into metal again. The three obvious phase transitions indicate that the structure of IBO becomes more unstable with the increase of pressure. The absorption spectra show that with the increase of pressure, the optical activity of IBO crystal grows higher, and three obvious structural transitions are, respectively, observed at 120, 150 and 180[Formula: see text]GPa.
Portal web de seguridad ciudadana para la ciudad de Cuenca de la Universidad de Cuenca

The main focus of the thesis project from the geographical point of view is the most dangerous criminal generation of maps and sectors.
These maps allow criminal graphically discover how the various criminal variables are distributed in space. To assist in the identification of agglomeration or dispersion of criminal variables and their special relationship with the situational and social characteristics. In presenting the results in graphical form facilitates the development of work plans aimed at targeting prevention and control. For the generation of tort sector map use behavioral data ie where certain behaviors occur, ie the place where criminal acts occur through the development of a database.
Climate cHallenges on coAstal and traNsitional chanGing arEas: WEaving a Cross-Adriatic REsponse

CHANGE WE CARE fosters concerted and coordinated climate adaptation actions at transboundary level. The project explores climate risks faced by coastal and transition areas contributing to a better understanding of the impact of climate variability and change on water regimes, salt intrusion, tourism, biodiversity and agro-ecosystems affecting the cooperation area. The main goal is to deliver integrated, ecosystem-based and shared planning options for different problems related to climate change (CC), together with adaptation measures for vulnerable areas to decision makers and coastal communities who may best benefit from it.
Isolation and characterization of bacterial diversity from soils supplemented with electrical transformer fluids

Repetitive enrichment of soils samples from an agricultural land and newly marked dumpsite on electrical transformer fluid yielded six bacterial species that have the capacity to utilize electrical transformer fluids (askarel) as carbon and energy source. Bacterial species namely: Micrococcus, Arthrobacter, Pseudomonas putida, Pseudomonas spp, Norcadia and Corynebacterium were identified using morphological and biochemical characteristics. The abilities of these bacterial species to utilize the electrical transformer fluids as carbon source in minimal salt medium (MSM); sub cultured in concentrations of 5, 10, 15 and 20μL of electrical transformer fluids were investigated for twentyÃ¢â‚¬Âone days period. Physiological changes in terms of biomass increase were monitored by measuring the pH and optical density of the culture medium. From the results obtained, there was observed a general decrease in the pH and increase in Optical density (O.D). The mean pH and O.D. readings ranged between (4.34Ã¢â‚¬Â6.13 and 0.073Ã¢â‚¬Â0.386) respectively. The decreased pH could justify for the acidic metabolites produced in the course of utilization of askarel as growth substrates. This study suggested that, the tropical ecosystems can provide exotic bacterial species that are capable of degrading or mineralizing polychlorinated biphenyls and their derivatives from dumpsites and agricultural soils.
Probes of holographic thermalization in a simple model with momentum relaxation

From the viewpoint of AdS/CFT correspondence, we investigate the holographic thermalization process in a four dimensional Einstein-Maxwell-axions gravity theory, which is considered as a simple bulk theory dual to a boundary theory with momentum relaxation. We probe the thermalization process using the equal time two-point functions and the entanglement entropy with the circle profile. We analyze the effects of momentum relaxation on the process in details and results show that the momentum relaxation gives longer thermalization time, which means it suppresses the holographic thermalization process. This matches the properties of the quasi-normal frequencies for the bulk fluctuations which the frequency violates from zero mode more profoundly for stronger momentum relaxation. We claim that is reasonable because the decay of the bulk fluctuations holographically describes the approach to thermal equilibrium in the dual theory.
GENERATIVE SOUND ART AS POEITIC POETRY FOR AN INFORMATION SOCIETY

This paper considers computer music in relation to broader society and asks what algorithmic composition can learn from the metaphysical shift which is happening in the so-called information societies. This is explored by taking the mapping problem inherent in the use of extra- musical models in generative composition and presenting a simple generative schema which prioritises sound, ex- ploiting the generative potential of digital audio. It is sug- gested that the exploration of such models has more than aesthetic relevance and that the interdisciplinary nature of digital sound art represents a microcosm of an emerging reality, thereby constituting a poietic playground for com- ing to terms with the implications and challenges of the information age.
SUstainability PERformance of LNG-based maritime mobility

Environmental pressure in port areas and in urban areas close to ports is high owing to emissions from ships, port machinery and transport to/from the port areas. LNG is proposed as a low-carbon clean fuel for marine transport in port areas. The boost of LNG marine and terrestrial propulsion may be a key to enhance the sustainability of port areas, protecting health of population and cultural heritage. However distribution networks and port infrastructures for the bunkering of LNG-powered ships requires technologies and solutions assuring a high level of safety in touristic areas of the Adriatic and Ionian see, avoiding trade-offs among environment protection and safety of passengers and personnel. _x000D_
The overall objective of the project is to increase the level of safety, environmental quality and sustainability of LNG maritime transportation in the Adriatic seas. It aims at providing a uniform framework to support the implementation of technical systems for the distribution and supply of LNG in port areas, meeting the requirements of the Seveso Directive (Directive 2012/18/EU)._x000D_
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The main outputs of the project are:_x000D_
1) A strategy for harmonized guidelines for the safety assessment of LNG supply systems in the Adriatic-Ionian area, sharing experience and practices derived from safety and security directives applied in conventional facilities._x000D_
2) An Action Plan, so as to share among EU the framework of the technical guidelines and best practices addressing the standardization of the technological solutions proposed for LNG supply._x000D_
3) Creation of a network establishing a permanent educational system in the area of safety and forming experts for port operators, maritime educational instructions, public authorities, and other stakeholders._x000D_
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The main benificiaries will be regional, national and port authorities. The project will contribute to the sustainable transport and mobility solutions by supporting safe use of LNG, as a fuel, in the ADRION area.
Mid- and far-ir optoelectronic devices based on bose-einstein condensation

Optoelectronic devices typically operate in the weak coupling regime between light and matter, for example in conventional lasers relying on population inversion to achieve optical gain. Recently there has been a surge of interest in quantum systems operating instead in the strong coupling regime, when the coupling strength of the light-matter interaction is so strong that new states – cavity polaritons – are created, that are partially light, partially material excitation. In semiconductors, exciton-polaritons have been the most widely studied type of strongly coupled system. Recently a new phenomenon has been realized exploiting intersubband transitions. The resulting excitations are called intersubband polaritons, and they have two remarkable properties: (i) a bosonic character that is maintained up to high carrier densities since they are not restricted by the Mott transition limit; (ii) large Rabi splittings. Although the scientific community has explored the basic science of intersubband polaritons, their potential for future and innovative optoelectronic devices has been entirely untapped.
The MIR-BOSE project will realize this potential, and demonstrate disruptive optoelectronic devices operating in the strong coupling regime between light and matter. We will demonstrate the first bosonic lasers operating in the mid-IR and THz ranges of the electromagnetic spectrum. Laser action here does not rely on population inversion, so we will achieve temperature independent operation and high powers. We will demonstrate a new concept of inverse-Q-switching leading to the generation of high power pulses in the mid-IR, overcoming severe bottlenecks in current technology. Finally, we will demonstrate non-classical/quantum light sources and devices, generating squeezed states of light in the mid-IR/THz spectral range for quantum optics. These new sources will have a major impact on several technologies and applications, being advantageous compared to current solutions.
Advanced filtration technologies for the recovery and later conversion of relevant fractions from wastewater

AFTERLIFE proposes a flexible, cost- and resource-efficient process framed in the zero-waste and circular economy approach for the recovery and valorisation of the relevant fractions from wastewater. The first step of such process is an initial step consisting of a cascade of membrane filtration units for the separation of the totally of solids in wastewater. Then, the concentrates recovered in each unit will be treated to obtain high-pure extracts and metabolites or, alternatively, to be converted into value-added biopolymers (polyhydroxyalkanoates). Moreover, the outflow of the process is an ultra-pure water stream that can be directly reused.

The outcomes of the project will be focused on:
- Demonstration of an integrated pilot using real wastewater from three water intensive food processing industries (fruit processing, cheese and sweets manufacturing) 
- Demonstration of the applicability of the recovered compounds and the value added bioproducts in manufacturing environments

The design and optimisation of the AFTERLIFE process following a holistic approach will contribute to improve performance and reduce the costs  associated to wastewater treatment by maximising the value recovery.
Evaluating continuum solvation models for the electrode-electrolyte interface: Challenges and strategies for improvement

Ab initio modeling of electrochemical systems is becoming a key tool for understanding and predicting electrochemical behavior. Development and careful benchmarking of computational electrochemical methods are essential to ensure their accuracy. Here, using charging curves for an electrode in the presence of an inert aqueous electrolyte, we demonstrate that most continuum models, which are parameterized and benchmarked for molecules, anions, and cations in solution, undersolvate metal surfaces, and underestimate the surface charge as a function of applied potential. We examine features of the electrolyte and interface that are captured by these models, and identify improvements necessary for realistic electrochemical calculations of metal surfaces. Finally, we reparameterize popular solvation models using the surface charge of Ag(100) as a function of voltage to find improved accuracy for metal surfaces without significant change in utility for molecular and ionic solvation.
Unravelling neuronal heterogeneity in energy homeostasis regulation

This MSCA Reintegration proposal is aimed to study the heterogeneity of neuronal populations implicated in the maintenance of energy balance. Because of their location, neurons in the arcuate nucleus of the hypothalamus (ARC) integrate nutrient and hormonal signals carried in the blood. Then, they regulate downstream neuron’s activity in order to adapt food intake and energy expenditure. Deregulation of energy homeostasis can lead to obesity and diabetes, two of the major chronic diseases in the EU. AgRP neurons, an ARC population, have a prominent role in the regulation of food intake and systemic insulin sensitivity. They establish axonal projections with several brain areas and recent evidences show that each sub-circuit can have a specific function in the regulation of food intake and/or glucose homeostasis. For this fellowship I propose to use an innovative experimental approach to investigate a specific novel AgRP neuronal subpopulation, characterized by the expression of the UDP-receptor, P2Y6, as a first step to unravel the heterogeneity of the total population. Although P2Y6 activation increases short-term food intake, its effects on glucose homeostasis are still unknown. I plan to combine new recombinase technologies with state of the art techniques to genetically identify the AgRP, P2Y6 subpopulation and then: 1) characterize their in vivo dynamic response to physiological activators; 2) map specific AgRP+, P2Y6+ sub-circuits and dissect their role in each facet of energy homeostasis; and 3) investigate new molecular markers, as possible drugable targets. Results from this project will unveil new aspects of neuronal heterogeneity that participate in the regulation of energy homeostasis and will contribute to design new strategies to curb the actual obesity trends. The completion of this MSCA fellowship represents an exceptional opportunity to reinforce my professional maturity and to develop my independent research line.
Selective Plating — Part 1

BIGNESS presents its own problems, as those engaged in overhauling Boeing 747 aircraft have already discovered. Take as an example, the problem of overhaul cadmium plating the wing outer cylinder on the main landing gear. This component is nearly 10 ft long and approximately 5 ft across, with a surface of approximately 100 square feet requiring electroplating. It was originally plated in a tank 5 ft by 6 ft by 12 ft deep, containing over 2500 gallons of solution. A tank of this capacity holds over $5000 worth of cadmium solution and nearly $15 000 worth of anodes. It requires a power supply of at least 7500 amperes. Total cost of such an installation, including cleaning and rinsing tanks, aproximates $50,000. Is any company willing to invest $50 000 in a new plating line required only to refinish one or two wing outer cylinders per month? Or, are they prepared to pack up large, cumbersome components, ship over long distances for outside plating, and wait impatiently for their return?
Research on efficient integrated systems for the manufacturing of complex parts based on unidirectional tapes for the automotive and aeronautical

More and more industrial sectors are demanding high performance composite materials to face new challenges demanded by the transport sector. Carbon and glass fibre unidirectional continuous tape reinforced composites are one of the most promising options. It would be reasonable to expect that the manufacturing methods to obtain composite parts made of this hybrid material will be capable to tailor-made and optimize even more the advantageous properties given by the tapes nature. However, at the moment, these technologies are not mature enough for a full industrial implementation. Main existing barriers are related to the high consumption of resources, lower rates of automation, high production of defective and the subsequent growth of the manufacturing costs. 
FORTAPE aims to solve these drawbacks through the development of an efficient and optimized integrated system for the manufacturing of complex parts based on unidirectional fibre tapes for its application in the automotive and aeronautical industry, with the minimum use of materials and energy.
To achieve this objective, three main routes for fibre impregnation will be researched to manufacture the unidirectional carbon and glass fibre tapes: novel heating up technologies, melted supercritical fluid-aided thermoplastic polymers and fluidized bed of powders. Novel combination of process-machine approaches will be applied in overmoulding and in-situ consolidation to manufacture the composite parts for the targeted sectors. Novel mathematical modelling and computational simulation concepts will be developed to support the structural optimization and the failure prevention and new instrumentation strategies for process control will be implemented for the selection of the best process. 
The FORTAPE consortium, led by CTAG, gathers 10 partners from 5 different European countries, and covers the whole value chain needed to develop new composite technologies with efficient use of materials and energy.
Structural biology of chromatin transcription

Transcription of protein-coding genes by RNA polymerase II (Pol II) governs cell identity and fate. We previously provided the structural basis of Pol II transcription initiation (ERC Advanced Grant TRANSIT: Sainsbury, Nature 2012; Lariviere, Nature 2012, Plaschka, Nature 2015) and of Pol II elongation regulation (ERC Advanced Grant TRANSREGULON: Vos, Nature 2018; Vos & Farnung, Nature 2018). These studies elucidated the mechanisms of transcription regulation. However, they were conducted on naked DNA, and not on chromatin, which is the natural template in cells and regulates transcription in many ways. As a consequence, the molecular mechanism underlying chromatin transcription and the regulatory interplay between chromatin and the transcription machinery remain poorly understood. Here I propose to take the next big step towards an understanding of the transcription mechanism and investigate the structural basis for Pol II transcription of chromatin templates. Integrated structural biology will provide structures of the transcription machinery on nucleosomal DNA. Nucleosomes are the building blocks of chromatin and regulate transcription in many ways. In particular, we will solve structures of pioneer factors bound to nucleosomes, to investigate how chromatin is opened locally for transcription (aim 1). We will solve the structure of the Pol II pre-initiation complex on the ‘+1’ nucleosome at the beginning of a gene, to understand how initiation is regulated by this specialized nucleosome (aim 2). Finally, we will determine structures of mammalian Pol II elongation complexes with many factors during nucleosome passage, to elucidate how Pol II transcribes chromatin (aim 3). Together with functional analysis in vitro and in vivo, these ground-breaking efforts will take the structural biology of transcription regulation to the chromatin level. The proposed research will also advance methods for the reconstitution and analysis of transient, higher-order complexes.
New heterogeneous catalyst materials for hydrogenation of co2 to formic acid: metallophthalocyanine-based 2d- and 3d covalent organic frameworks

In CO2COFs project we will meet the world’s need for new heterogeneous catalyst materials for catalytic CO2 hydrogenation to formic acid (FA) by developing novel metallophthalocyanine (MPc)-based covalent organic frameworks (COFs) with high crystallinity and large surface area for renewable hydrogen storage in formic acid (FA). Althought heterocatalytic CO2 hydrogenation to FA is one of the most promising conversions, relatively few catalytic materials have been reported for this transformation. Furthermore, there are many studies of the development of the homogeneous catalyst for CO2 hydrogenation to FA, but heterogenization of homogeneous Ru complexes by incorporating them onto supporting material is essentially unexplored. In CO2COFs project we will answer the demand by synthesizing MPc-based 2D- and 3D COFs which are highly crystalline materials offering a defined porous structure with definite binding sites for organometallic complexes. Prepared materials will be fully characterized and investigated in hydrogenation of CO2 to FA. One of the main targets of CO2COFs is to achieve recyclable heterogeneous catalysts with catalytic activities and efficiencies among the best reported worldwide. The results of CO2COFs project is expected attract the attention of companies related with catalysts and formic acid processing.
Process Review as Panacea: A Critique of Process Review Advocacy in the European Union

This article responds to the trend of process review advocacy in EU academic literature. It offers a critical assessment of process review, broadly defined as the idea that the Court ought to focus on the process by which decisions are made when conducting its review of a given measure. The article explores John Hart Ely’s theory of process review, developed in the context of the US Supreme Court, and how this has influenced the EU’s own process review advocates. It seeks to add value to this literature by engaging with the extensive critique of Ely’s theory. In doing so, it argues that process review may fail to live up to the expectations placed upon it, both in terms of the outcomes of review and its legitimacy.
(5158.03042018.125000213) INTERNATIONALISATION PROJECT

WITH WHAT IS UNDER CONSIDERATION, THE COMPANY INTENDS TO STRENGTHEN AND EXPAND ITS MARKET, IN PARTICULAR TOWARDS THE UNITED STATES AND FAR EAST COUNTRIES, THROUGH THE PARTICIPATION IN INTERNATIONAL TRADE FAIRS. ARE THESE EVENTS IN WHICH THE COMPANY POINTS OUT? TO A WIDE VISIBILITY? WHAT WILL YOU ALLOW? TO FURTHER INCREASE THEIR TRADE PROPOSAL ABROAD.