SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Tumor compartment-specific effects of p70s6k in early triple negative breast cancer: regulation of antitumor immune response and therapeutic implications

Breast cancer is the most common cancer among women with significant death rates and economic impact. In daily routine clinics, breast cancer is usually classified on the basis of three immunohistochemical markers (ER, PR and HER2). Triple-negative breast cancer (TNBC) is a subtype defined by the negativity of all these markers, which shows an adverse clinical course. It is characterized by a considerable gene expression heterogeneity that leads to a lack of availability of targeted therapies. Positive clinical trials relying on various forms of immunotherapy have shifted the paradigm of diverse malignancies from cytotoxics to novel immunomodulator drugs. The results in TNBC, however, are not as positive. In a recent taxonomic effort of the hosting group, TNBC has been re-classified on the basis of the activation status of six protein kinases, which in turn constituted novel targets for this disease. One of them, the 70-kDa ribosomal protein S6 kinase (P70S6K), which was associated with an adverse clinical outcome, showed negative correlation with tumor-infiltrating lymphocytes (TILs) abundance. The fact that P70S6K has been associated with immunosuppressive mechanisms and that there is a positive correlation between the number of TILs and the clinical outcomes in TNBC, suggests that the role of P70S6K may be related to pleiotropic and/or opposing properties of tumor progression. By using a combination of multiparametric flow cytometry, bulk/single-cell gene expression analysis and in vivo experiments in mouse models, this proposal aims to unravel the impact of P70S6K modulation over the already known relevant immune-oncology targets/axes as well as the therapeutic consequences of P70S6K blockade in TNBC. These studies will provide a better understanding of the lymphocyte-related responses modulated by P70S6K, with the potential to find new therapies for patients suffering from TNBC and possibly a broader range of malignances.
Quantum-Enhanced optical magnetometers

During the past ten years tools from Quantum Optics such as quantum-non-demolition (QND) measurements and squeezed light have emerged as powerful means to control quantum states of matter, perform ultra-sensitive measurements, and enhance physical systems beyond their classical limits.  At the same time optical magnetometers developed within the discipline of Atomic Physics have established themselves as the most sensitive detectors of magnetic fields with current performance reaching the limits of classical techniques. To date, in a proof-of-principle way, QND and squeezed light have been used to improve the performance of these instruments independently but not within the same device. Their simultaneous use in a best-in-class magnetometer remains an open challenge. To achieve this ambitious research goal we propose to combine QND and squeezed light resources to magnetometry at large atomic densities, i.e. in a regime where spin-exchange collisions dominate the spin dynamics. This novel approach will be key in enhancing current technology most suitable to address challenges in the real world. 
QUTEMAG combines a wealth of expertise in Optical Magnetometry and Quantum Optics. The Experienced Researcher Dr. Ricardo Jiménez Martínez, is an expert in Optical Magnetometry. The Supervisor Professor Morgan Mitchell is a leader in QND methods and quantum light pioneering the techniques that will enable the quantum-enhancement of optical magnetometers in the proposed work. The goal of the training program of the researcher is to develop new research competencies in quantum optics and managing skills of interdisciplinary research in Quantum Optics and Metrology, Atomic Physics and Photonics.The Host Institution, ICFO-The Institute of Photonic Sciences in Spain, provides a world-class research and training environment to achieve the research and training goals of QUTEMAG during the 24-month span of the project.
The value of coordinated hydropower bidding in the Nordic day-ahead and balancing market

Abstract Modern power markets often consist of a series of sequential markets where power is traded. Market agents must coordinate their trading strategy across all markets. In this paper, we formulate the mult-market bidding problem for power producers as a stochastic program. This formulation is implemented within the framework of optimization models used by the Nordic hydropower industry. We also present how input to the stochastic program may be generated by using a forecast-based scenario generation method combined with time-series models that predicts future prices and turnovers in the markets. The model is applied in a case study to investigate the value of participating in the Nordic day-ahead and balancing market. A producer may participate in the balancing market either by considering the markets sequentially or coordinated. Using cases with limited and perfect information about the balancing market to calculate lower and upper bounds, we find that the value of participating in the balancing market using the sequential approach is between 0.8 and 2.6%. Using the coordinated approach, the producer may gain between 1.4 and 2.9%. The value of coordination, i.e. the value of using the coordinated over the sequential approach, is found to be higher in the limited information case (1.7%) than in the perfect information case (1.1%). This indicates that, the more uncertainty, the higher is the value of coordination.
Stability of Sugar Solutions: A Novel Study of the Epimerization Kinetics of Lactose in Water

This article reports on the stereochemical aspects of the chemical stability of lactose solutions stored between 25 and 60 °C. The lactose used for the preparation of the aqueous solutions was α-lactose monohydrate with an anomer purity of 96% α and 4% β based on the supplied certificate of analysis (using a GC analytical protocol), which was further confirmed here by nuclear magnetic resonance (NMR) analysis. Aliquots of lactose solutions were collected at different time points after the solutions were prepared and freeze-dried to remove water and halt epimerization for subsequent analysis by NMR. Epimerization was also monitored by polarimetry and infrared spectroscopy using a specially adapted Fourier transform infrared attenuated total reflectance (FTIR-ATR) method. Hydrolysis was analyzed by ion chromatography. The three different analytical approaches unambiguously showed that the epimerization of lactose in aqueous solution follows first order reversible kinetics between 25 to 60 °C. The overall rate constant was 4.4 × 10(-4) s(-1) ± 0.9 (± standard deviation (SD)) at 25 °C. The forward rate constant was 1.6 times greater than the reverse rate constant, leading to an equilibrium constant of 1.6 ± 0.1 (±SD) at 25 °C. The rate of epimerization for lactose increased with temperature and an Arrhenius plot yielded an activation energy of +52.3 kJ/mol supporting the hypothesis that the mechanism of lactose epimerization involves the formation of extremely short-lived intermediate structures. The main mechanism affecting lactose stability is epimerization, as no permanent hydrolysis or chemical degradation was observed. When preparing aqueous solutions of lactose, immediate storage in an ice bath at 0 °C will allow approximately 3 min (180 s) of analysis time before the anomeric ratio alters significantly (greater than 1%) from the solid state composition of the starting material. In contrast a controlled anomeric composition (~38% α and ~62% β) will be achieved if an aqueous solution is left to equilibrate for over 4 h at 25 °C, while increasing the temperature up to 60 °C rapidly reduces the required equilibration time.
The role of the prefrontal cortex in pain modulation

Existing knowledge identifies the prefrontal cortex (PFC) as the modulatory area for pain. Previous neuroimaging studies suggest the existence of the cortico-cortical pathway, an alternative pain modulatory pathway distinct from the descending modulatory pathway of pain. However, little is known of the extent, mechanism and underlying substrate of the modulation. The objective of this study is therefore to explore the role of the PFC in pain modulation. To examine the extent of PFC involvement in pain, meta-analyses of imaging studies in healthy volunteers and patients with chronic pain were performed. Using Gaussian-process regression (GPR) analysis, brain maps were produced from foci of activation as reported in the studies. Since structure dictates function, our next study was to performprobabilistic tractography on diffusion-weighted brain images to ascertain the connection probability of lateral PFC subdivisions and pain-related brain regions as well as intrinsic PFC connections. Two behavioural studies were conducted to investigate cognitive modulation of pain. The first was a study to assess the subjective and physiological correlates of cognitive stress, as previously used in stress-induced analgesia studies. The second was to investigate the involvement of the endogenous opioid system inthe cognitive modulation of pain through effortful reappraisal and contextual modulation. Meta-analyses in healthy volunteers and chronic pain patients revealed activation mainly in the lateral aspect of the PFC due to pain. Distinct pattern of activation was demonstrated in patients with significant ventrolateral PFC (VLPFC) activation across subtypes of chronic pain. Probabilistic tractography further illustrate the functional significance of lateral PFC subdivisions by demonstrating differential connection probability to pain-related brain regions; dorsolateral PFC (DLPFC) regions displayed higher connection probability with brain regions serving more sensory-discriminative function while VLPFC showed high connection probability with both sensory-discriminative and affective regions. Behavioural study of stress showed that cognitive stress failed to induce significant increases in biomarkers of stress, and was not affected by increased level of difficulty. Lastly, behavioural study on contextual modulation and reappraisal confirmed opioid mediation for contextual modulation while negating its involvement in effortful reappraisal. Findings from this studyillustrate the extent of PFC involvement in pain modulation especially in chronic pain patients and provide further evidence of an alternative pathway distinct from the opioid-mediated descending inhibitory pathway.
European network for training and research into cross-border practices

Problems addressed
• Cross-border practices are emerging throughout Europe, and require an appropriate training organisation for the practices and requirements of the Interreg programmes financing them.
• There are many sources of training for cross border cooperation - these require organisation and adaptation for cross border professions and activities. 
• An extremely diverse range of initiatives for research into the cross border area have been set up - these should be ‘connected up’ to the realities in the field and concrete projects

Objectives
• Increasing the professionalism of the organisations and individuals involved in cross border cooperation via the development of initial or ongoing training initiatives
• Enabling cross border professionals to carry out exchanges regarding their practices by means of the transmission and appropriation of best practice and expertise, and linking up researchers and organisations active in the territories.
• Collectively and progressively developing a shared culture for transfer to the new EU member states. 

Approach and methodology
• The capitalization - by networking among experts - of training facilities and accompanying resource centres.
• Boosting professionalism by creating training modules. 
• The development of research corresponding to practice in the field.
Search for narrow high-mass resonances in proton–proton collisions at s=8 TeV decaying to a Z and a Higgs boson

The first search for a narrow, high-mass resonance decaying into Z and Higgs (H) bosons is presented. The final state studied consists of a merged jet pair and a tau pair resulting from the decays of Z and H bosons, respectively. The analysis is based on a data sample of proton-proton collisions at a center-of-mass energy of 8 TeV, collected with the CMS experiment in 2012, and corresponding to an integrated luminosity of 19.7 inverse femtobarns. In the resonance mass range of interest, which extends from 0.8 to 2.5 TeV, the Z and H bosons are produced with large momenta, which implies that the final products of the two quarks or the two tau leptons must be detected within a small angular interval. From a combination of all possible decay modes of the tau leptons, production cross sections in a range between 0.9 and 27.8 fb are excluded at 95% confidence level, depending on the resonance mass.
ECOlogical observing System in the Adriatic Sea: oceanographic observations for biodiversity

ECOSS overall objective is the establishment of the ECOlogical observing system in the Adriatic Sea (ECOAdS), shared between Italy and Croatia, able to integrate ecological and oceanographic research and monitoring with Natura 2000 conservation strategies. Building on the facilities, infrastructures and long term ecological data existing in the Programme area and developing specific case studies, ECOSS will enhance the marine observational capacities for improving the conservation status and the expansion of the marine component of Natura 2000 network. The synergies and feedbacks among the main conservation management questions, ecological variables and key oceanographic processes will be assessed, basing on the connectivity among habitats and species in coastal and offshore waters.
Cuniculture au pâturage et sous certification Agriculture Biologique en France : fonctionnement des systèmes, performances et règlementation

En France, l’élevage cunicole conventionnel est réalisé en système hors-sol (environ 700 éleveurs). La cuniculture alternative avec accès des lapins à l'extérieur, est essentiellement sous certification « Agriculture Biologique » (AB) reste marginale (environ 50 cuniculteurs) et ne produit pas suffisamment pour répondre à la demande des consommateurs. Nous faisons ici la synthèse des connaissances sur le fonctionnement et les performances des systèmes cunicoles AB ou au pâturage. Le lapin étant un animal herbivore, la cuniculture AB privilégie le pâturage, et bien maîtrisée elle peut rémunérer un demi SMIC avec 40 lapines reproductrices sur 4 ha (pâtures et cultures complémentaires). Pour les porteurs de projet, outre l'accès à la terre, la gestion de la prophylaxie et de l'alimentation sont deux contraintes fortes des systèmes cunicoles AB. Le nouveau règlement Européen, applicable depuis janvier 2022, préconise l'utilisation maximale du pâturage mais, de façon contradictoire, permet d'installer un troupeau de 40 lapines sur seulement 200 m² de pâturage et n'oblige pas à une rotation des parcs entre deux groupes d'animaux, ce qui élève le risque de parasitisme. Les récentes études ont quantifié l’ingestion d'herbe (30 à 80 g MS/jour/lapin) et la croissance du lapin au pâturage (15 à 25 g/jour). Le cycle productif d'un atelier cunicole AB est extensif avec une moyenne de 2,7 mise bas par lapine et par an (contre 6,7 en système hors sol). Une application smartphone d'assistance à la conduite d'élevage (GAELA) a été récemment développée pour construire un référentiel de performances permettant de soutenir le développement de la cuniculture AB ou au pâturage.
Functional Properties and Postharvest Utilization of Commercial and Noncommercial Banana Cultivars

Banana (Musa spp.) is one of the world's most important crops cultivated in tropical and subtropical regions of the world. Banana is a major source of macro-elements, especially potassium, and contains health-beneficial ingredients such as resistant starch, total dietary fibers, rapidly digestible starch, and slowly digestible starch. Oligosaccharides (fructooligosaccharides and inulin) and polyphenols ((+)-catechin, (-)-epicatechin, (-)-epigallocatechin, and gallic acid) are other ingredients present in bananas that have found application in the prevention of muscular contractions, regulation of blood pressure, prevention of colon cancer and diabetes, and in the cure of intestinal disorders when unripe. This review identifies the different commercial and noncommercial banana cultivars and their utilization. Commercial cultivars include Williams (M. acuminata cv. Williams), Dwarf Cavendish (M. acuminata cv. Petite Nain), Chinese Cavendish (M. acuminata cv. Chinese Cavendish), Grand Nain (M. acuminata cv. Grand Nain), and Goldfinger (M. acuminata cv. Goldfinger), with Mabounde and Luvhele identified as noncommercial varieties. Banana postharvest utilization includes its use as functional foods, prebiotics, probiotics, nutraceuticals, and processing into value-added products.
Preparation and characterization of the heat-resistant UV curable waterborne polyurethane coating modified by bisphenol A

In this study, the modified ultraviolet (UV) curable waterborne polyurethane was obtained from isophorone diisocyanate (IPDI), polyethylene glycol (PEG, MW=600), α,α-dimethylol propionic acid (DMPA), hydroxyethyl acrylate (HEA) and bisphenol A. The rigid moiety was introduced into the main chain of polyurethane to improve its heat-resist- ance. The copolymer structure was confirmed by Fourier transform infrared spectroscopy (FT-IR). Thermal property and UV curable behavior of the coatings were investigated. The glass transition temperature (Tg) of the modified film was deter- mined by differential scanning calorimetry (DSC). Thermal gravimetric analysis (TGA) was employed to investigate the thermal stability of the modified film. The results show that the average particle diameters increased from 69.25 to 95.12 μm as the content of bisphenol A increased from 0.00 to 9.25%. The optimum bisphenol A dosage was 7.23% (wt%), the Tg of the modified film increased by 7.07°C and 5% weight-loss temperature (233°C) increased by 14°C. The optimum irradiation time was 10-20 minutes after the coatings being painted on an armor plate at room temperature and initiator dosage was 5% (wt%) of the latex.
Mechanism of hydrogenation and transfer hydrogenation of polar unsaturations catalyzed by non n-h systems

The project addresses the reduction of polar unsaturations catalyzed by metal complexes under strongly basic conditions. This is an important reaction that enters the manufacture of many high added value fine chemicals. The role of the strong base for catalysts that do not contain active protons in the ligand donor functions is unclear, as well as the relationship between the mechanisms of hydrogenation by H2 and transfer hydrogenation. The sought mechanistic understanding can lead to the design of improved catalysts and operating conditions. The project will be implemented by a multifaceted approach that includes synthesis, characterization, catalysis, kinetics, and computations and be further enriched by parahydrogen NMR studies through a 3-month secondment at the University of York. This multisectorial training will put the ER on an excellent basis to further develop his professional career in research. The ER has an excellent basic training from one of the premier institutions in his Country and an outstanding publication record. The ER will be expected to mentor undergraduate students in the group, to deliver 4 presentations at group meetings, to present his results in at least one international conference and to contribute to drafting research publications. The project is expected to lead to high impact fundamental knowledge resulting in high quality publications, presentations at international conferences, and popularized articles in University magazines.
Mit IoT-Sensoren und fortschrittlichen Datenverarbeitungsalgorithmen entsteht ein digitales Entscheidungssystem im HoReCa-Sektor.

Ziel des Projekts ist es, ein Ökosystem rund um Daten zu schaffen, das Kunden von Pubs und Restaurants, Eigentümern dieser Räumlichkeiten sowie Bierproduzenten einen Mehrwert bietet. Die Erforschung eines solchen Systems (einschließlich IoT-Integrationslösungen, moderne Methoden zur Erfassung, Verarbeitung und Analyse von Daten sowie die Möglichkeit, von überall auf der Welt auf Echtzeit-Bierverbrauchsdaten zuzugreifen) ist die zentrale Achse des eingereichten Projekts. Der Echtzeitzugriff auf Daten ermöglicht es Pub- und Restaurantbesitzern, Bestands- und Produktportfolios besser zu verwalten und somit den Kundenbedürfnissen besser gerecht zu werden. Kunden, die Zugang zu Informationen über die Präferenzen anderer haben, werden in der Lage sein, ihre eigenen Entscheidungen auf fundiertere Weise zu treffen, während die Hersteller Zugang zu Daten über den Verbrauch ihrer Produkte erhalten werden (die 20 % ihrer Verkäufe in Polen abdecken), die aufgrund des Grads der Verbreitung und des Mangels an digitalen Methoden zur Erhebung dieser Daten bisher außer Reichweite waren. Die geplante Entwurfsarbeit umfasst unter anderem die Erforschung der Integration von Sensoren (IoT), die Daten in Echtzeit an ein zentrales Data Warehouse sammeln und übertragen, sowie die Erstellung und Optimierung von Datenverarbeitungsalgorithmen sowie Plattformen, die den Zugriff auf verarbeitete Daten und Analysen ermöglichen. Bestehende Lösungen in diesem Bereich existieren entweder nicht oder sind sehr teuer (z. B. Durchflussmesser) oder sind nicht skalierbar (aufgrund der Heterogenität der verfügbaren Geräte). Die Innovation der getesteten Lösung besteht in der Nutzung der neuesten technologischen Fortschritte in einem sehr traditionellen Sektor, der sich auf den direkten Kontakt mit dem Kunden konzentriert (und damit einen schnellen technologischen Ausbau aufgrund geringer Eintrittsbarrieren und mangelnder Konkurrenz ermöglicht). Das Projekt besteht aus 4 Stufen der industriellen Forschung, 1 Stufe der Entwicklungsforschung und einer Phase der Vorimplementierungsforschung. Jede Phase der Planung
ENERGY RELIEF CONTROL IN A MECHANICAL VENTILATOR

The present invention relates to a solution for controlling the pressure/flow of breathing gas to a mechanical ventilator (4) by using an energy of breathing analysis and further to provide a pressure relief during exhalation and a trigger determination when to start the pressure relief using energy content of breathing in analysis for determining a pressure curve form during at least a portion of the expiration phase.