SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Automatic method and apparatus for closing a toe end of a hose utilizing a straight line stitch

Disclosed is an invention relating to a method and an apparatus for closing the toe end of a hose material, wherein the toe portion of the hose material is united in such a way that the toe portion can be closed with a straight line stitching after the material is spread out laterally and caused to travel in a lateral direction.
Cultural Routes for Sustainable Social and economic Development in Mediterranean

There is a need for building up an area of peace and stability in the Mediterranean, reducing disparities, increasing opportunities for decent life and jobs for all, promoting dialogue and understanding for peaceful coexistence. The CROSSDEV project proposes a way to address these challenges through the exploitation of local culture and heritage to be turned into assets for socio-economic local development. CROSSDEV expects to increase tourism competitiveness and attractiveness of less known destinations and rural areas, enhancing the Cultural Routes experiences such as those of the Council of Europe (e.g. Phoenicians Route and IterVitis), Palestine (Abraham Path) and Jordan (Jordan Trail). To achieve this goal, the project will set up a cross-border tourism framework to enhance sustainable tourism policies, to promote tourism-related business and to develop community-led action plans. CROSSDEV will enable to increase skills and knowledge, contributing to better tourism practices which benefit socio-economic development and the protection of the environment and cultural heritage.
PENDEKATAN METODE SIX SIGMA (DMAIC) UNTUK PENINGKATAN KUALITAS PRODUK BONCABE DI CV KOBE & LINA FOOD

CV . Kobe & Lina Food is engaged in manufacturing food industry. Data processing is done to achieve continuous quality improvement towards the target of Six Sigma, which is using the methodology DMAIC ( Define Measure Analyze Improve Control ). Characteristics of product weight have 84,100 DPMO to the sigma level of 2.88, and disability packaging process has 6,010 DPMO to the sigma level of 4.01. Known to cause defects largest packaging process due to setting the machine with a percentage of 27% of the total disability. The cause of the weight that is not standards-compliant due to the negligence of the operator. Fixes a problem with the method 5W - 2H. This method is carried out improvements to the working methods of inspectors and operators. Implementation and measurement re- sigma level, for the weight of bonCabe sigma level to 4.30. To improve the quality of the products the company needs to implement a Six Sigma program. Keywords: Quality, Six Sigma, DMAIC, Defect.
Next generation sequencing of triple negative breast cancer to find predictors for chemotherapy response

In triple negative breast cancers (TNBC) the initial response to chemotherapy is often favorable, but relapse and chemotherapy resistance frequently occur in advanced disease. Hence there is an urgent need for targeted treatments in this breast cancer subtype. In the current study we deep sequenced DNA of tumors prior to chemotherapy to search for predictors of response or resistance.Next generation sequencing (NGS) was performed for 1,977 genes involved in tumorigenesis. DNA from 56 pre-treatment TNBC-biopsies was sequenced, as well as matched normal DNA. Following their tumor biopsy, patients started neoadjuvant chemotherapy with doxorubicin and cyclophosphamide. We studied associations between genetic alterations and three clinical variables: chemotherapy response, relapse-free survival and BRCA proficiency.The mutations observed were diverse and few recurrent mutations were detected. Most mutations were in TP53, TTN, and PIK3CA (55 %, 14 %, and 9 %, respectively). The mutation rates were similar between responders and non-responders (average mutation rate 9 vs 8 mutations). No recurrent mutations were associated with chemotherapy response or relapse. Interestingly, PIK3CA mutations were exclusively observed in patients proficient for BRCA1. Samples with a relapse had a higher copy number alteration rate, and amplifications of TTK and TP53BP2 were associated with a poor chemotherapy response.In this homogenous cohort of TNBCs few recurrent mutations were found. However, PIK3CA mutations were associated with BRCA proficiency, which can have clinical consequences in the near future.
Mapkite to market

The goal of M2M is to conduct a market analysis and to elaborate a business plan to market mapKITE.
MapKITE is a new mobile tandem, terrestrial and aerial, geodata acquisition and orientation/calibration system and method that combines an aerial unmanned (drone) and a land mobile mapping system. In a mapKITE mission, the mapping drone follows the mapping land vehicle by means of a stream of waypoints generated in the vehicle and transmitted to the drone. The land vehicle carries metric targets to materialize accurate kinematic ground control points. In the mission, inertial, GNSS, odometric and imaging data are recorded. In post-processing, these data are combined in a new way for accurate georeferencing purposes.
The Galileo signals and their unique ranging precision and multipath mitigation features are an enabler of mapKITE.
MapKITE is a high-accuracy and high-resolution solution for the civil engineering and other professional communities that need geoinformation along corridors and their neighbourhood. It is generally accepted that there is an historical lack of a cost efficient technical solutions for corridor mapping. Corridor mapping is the fundamental source of geoinformation for transportation, energy and other linear infrastructures that shall be monitored repetitively (for planning, construction, maintenance, etc.).By combining drone and land mobile mapping methods with a number of novel ideas and algorithms, mapKITE results in a low cost, robust, automated and efficient product for the benefit of general cartography, civil engineering  (road inventory and maintenance, pavement monitoring, road safety, environmental impact, etc.) cadastre, environment among others, as well as, in future, urban 3D mapping.
In the proposal we provide additional technical information, and show the market need and commercial feasibility of mapKITE.GeoNumerics has the will and capacity to bring mapKITE to market. MapKITE is an invention of GeoNumerics (Spain and USA patents).
An innovative class of nanoparticles (“smartcubes”) for the targeted delivery of protein therapeutics

'SmartCubes' are an innovative class of nanoparticles for the targeted delivery of protein therapeutics. The objective is to deliver high levels of membrane proteins to cancer cells to combat disease. I will achieve this by creating novel 'sponge-like' targeted nanoparticles (SmartCubes) to selectively deliver unprecedented levels of a cancer therapeutic protein to colon adenocarcinoma cells.

‘SmartCubes’ are based on a cubic membrane structure. They contain a highly stable lipid bilayer displaying a 'honeycomb-like' construction. This structure has prevented previous applications as the water channels were too small for large proteins to enter and reconstitute into the membrane. I am uniquely able to tune the sizes of the water channels within the 'SmartCubes' to create water networks sufficiently large to house a whole new class of proteins. I will achieve this new class of nanoparticles by creating 'SmartCubes', modifying the outer surface of the 'SmartCubes' with a selective antibody, loading the cubic membrane with a cancer therapeutic protein and delivering them to cancer cells.

Protein therapeutics are an exciting alternative to conventional cancer treatments due to reduced side effects and their high target selectivity. I can surpass previous attempts which were limited by rapid protein degradation and the instability of the delivery vehicle. As protein therapeutics increase in complexity, there is a need for stable, high surface area, membrane based delivery systems. This project, hosted in the 2014 European life sciences group of the year, will transform my fundamental research into a platform technology that will revolutionise the field of protein therapeutics.
Manipulation of mental models of anatomy in interventional radiology and its consequences for design of human–computer interaction

Interventional radiology procedures require extensive cognitive processing from the physician. A set of these cognitive functions are aimed to be replaced by technology in order to reduce the cognitive load. However, limited knowledge is available regarding mental processes in interventional radiology. This research focuses on identifying mental model---related processes, in particular during percutaneous procedures, useful to improve image guidance during interventions. Ethnographic studies and a prototype-based study were conducted in order to perform a task analysis and to identify working strategies and cognitive processes. Data were compared to theories from visual imagery. The results indicate a high level of complexity of mental model construction and manipulation, in particular when mentally comparing mental model knowledge with radiology images on screen (e.g., to steer a needle correctly). Regarding current interface support, most difficult is the interpretation and selection of oblique views. New interface principles are needed to bring cognitive demands within reasonable human range, and also accompanying cognitive work strategies should be developed.
Finite element modelling of stresses and failure within plasma spray thermal barrier coating systems

Air plasma sprayed thermal barrier coating (APS TBC) systems are usually applied to engine components to reduce the temperature of the substrate and increase the efficiency of engines. However, failure of these coatings leads to oxidation and corrosion of the substrate. Therefore, a thorough understanding of the coating failure is necessary to predict the lifetime of coated components.
This project has carried out stress analysis and prediction of subsequent failure of APS TBC systems associated with sintering of the TBC, oxidation of the bond coat (BC), substrate geometry, undulations at the coating interfaces and coating fracture toughness. Stress analysis is crucial for predicting TBC failure as stresses in the vicinity of the coating interfaces cause cracks and subsequent coating delamination.

The Finite element (FE) method was used for stress analysis of TBC systems at high temperature stage and at cooling stage after operation. Initially, FE model of an axisymmetric unit cell representing the slice of a coated cylinder was used. Different radii for cylinders were used to investigate the significance of substrate curvature on coating stresses. The effect of asperities at the coating interface on residual stresses was observed using 3D models. The models were built based on the actual geometries of asperities, which were extracted from 3D SEM images of the coating interfaces. An Arrhenius approach was utilised to implement changes in mechanical and physical properties of TBC due to sintering. BC oxidation and related changes in its composition were also implemented. The accuracy of assumptions for FE models was validated by comparing the evaluated stresses against experimental results by project partners. Finally, the effects of stresses and fracture toughness of the coatings and coating interfaces on failure of the TBC system were studied, using cohesive surface modelling and extended finite element modelling (XFEM) methods.
Habitability and Human Factors Contributions to Human Space Flight

This slide presentation reviews the work of the Habitability and Human Factors Branch in support of human space flight in two main areas: Applied support to major space programs, and Space research. The field of Human Factors applies knowledge of human characteristics for the design of safer, more effective, and more efficient systems. This work is in several areas of the human space program: (1) Human-System Integration (HSI), (2) Orion Crew Exploration Vehicle, (3) Extravehicular Activity (EVA), (4) Lunar Surface Systems, (5) International Space Station (ISS), and (6) Human Research Program (HRP). After detailing the work done in these areas, the facilities that are available for human factors work are shown.
cross-border network INTER-exchange of students for Mediterranean skills in the sustainable construction of the InnovAtion for the environment.

This project will implement joint training actions to promote sustainable quality employment through cross-border mobility in the blue and green growth priority areas and exchange innovative cross-border learning energy saving methodologies. It responds to the types of actions of the Third Appeal to help develop a reference model for Sustainable Building in the Mediterranean. Based on technical construction and renovation solutions adapted to the Mediterranean climate, the "Mediterranean living" model was developed in 2010. It will constitute the basis for the planned mobility project. The Partnership is composed of innovative, equipped training facilities currently active. Some examples: The training centre for apprentices of the CMA of Southern Corsica will contribute original techniques and pedagogical know-how. Lucense has an exhibition and training centre dedicated to the Mediterranean Living model; CONFINDUSTRIA CNS has a theoretical and hands-on training infrastructure that collaborates with the Mediterranean Living exhibition centre in Cagliari. After evaluating the beneficiaries’ individual needs, the partners’ harmonised educational tools will offer a Study Trip to the other country of the Cooperation area, alternating practical activities, actual work and theory, in addition to an e-learning language course before the trip. The e-learning language course affords the broadest dissemination of educational content and results and has a high potential for replicability.
Développement de HANDICRAFT par la promotion sur les marchés d’exportation

Sa 42799(2015/X) Le projet sera mis en œuvre dans le cadre du BPP MEBLE WORLD PERSPECTIVE RYNEK: ÉMIRATS ARABES UNIS. Les activités seront menées dans les domaines suivants: ROYAUME-UNI, POLOGNE, ÉMIRATS ARABES UNIS. Dans le PROJET PROJET, les activités promotionnelles seront menées par: —missions de sortie — stands lors de foires commerciales et de conférences — activités promotionnelles supplémentaires La requérante réalisera le projet en réservant des lieux d’exposition au salon, en effectuant des frais d’inscription et des inscriptions dans le catalogue des foires commerciales, en organisant des stands d’exposition au salon et en effectuant des missions de sortie. Les foires commerciales sélectionnées auxquelles le candidat participera en tant qu’exposant sont: 1.JANVIER FURNITURE SHOW 2.BBC Gardeners’ World Live 3.Manchester FURNITURE SHOW 4.WARSAW HOME La requérante effectuera également une mission sur le marché des Émirats arabes unis lors de l’Indice International Design 2020. LE DEMANDEUR A CONFIRMÉ LA POSSIBILITÉ DE PARTICIPER À DES FOIRES SÉLECTIONNÉES, CONFORMÉMENT À LA NOTE S.15 DES INSTRUCTIONS POUR LE REMPLISSAGE DE LA DEMANDE. Le demandeur utilisera la visualisation MPG. Le produit d’exportation sera: mobilier HANDICRAFT innovant en bois 100 % massif (cuc, peuplier, cendre, orme, hêtre, érable, noix, mâchoire, acacia). Le groupe se compose de produits du domaine de la spécialisation intelligente: KIS 2. TECHNOLOGIES, PROCÉDÉS ET PRODUITS INNOVANTS DU SECTEUR AGRO-ALIMENTAIRE ET FORESTIER XII. Personnalisation des meubles PRODUCTION 1. Mobilier à usage spécial, y compris les immeubles de meubles; meubles d’un confort accru; les meubles qui réduisent les déficits de santé, les meubles qui soutiennent le développement approprié et le maintien en bon état, éliminant l’impact négatif des facteurs de civilisation, ainsi que l’intégration des meubles avec les systèmes numériques et électroniques, qui sont conformes à la section C, section 31 de la classification PKD 2007. LE PROJET SERA MIS EN ŒUVRE À PARTIR DES RESSOURCES PROPRES DU DEMANDEUR PROVENANT DES ACTIVITÉS OPÉRATIONNELLES EN COURS.
Diversity and spatial distribution of vegetative compatibility types and mating types of Cryphonectria parasitica in the Aydın Mountains, Turkey

In this study, the population structure of the chestnut blight fungus Cryphonectria parasitica in the Aydin Mountains was investigated to make inferences about fungal reproduction and population diversity. A total of 213 C. parasitica isolates from eight subpopulations were used to determine vegetative compatibility (vc) and mating types of the population. Furthermore geostatistical analysis was performed to define the spatial structure of the population. The results showed that the isolates were vegetatively compatible with the European vc types of either EU-1 or EU-12. Both vc types were found in almost all subpopulations, but their frequencies varied depending on location. The results of a PCR assay showed that both mating types of C. parasitica (MAT-1 and MAT-2) exist in the population. MAT-1 comprised 65% of the total isolates, and the ratio of mating types was significantly skewed from 1:1. Genotyping based on combined vc and mating type data revealed four genotypes: EU-1/MAT-1 (28.6%), EU-1/MAT-2 (34.7%), EU-12/MAT-1 (36.2%) and EU-12/MAT-2 (0.5%). Geostatistatical analysis indicated that vc types, mating types and vc/mating genotypes were spatially autocorrelated and clustered in their distributions. Results suggested that C. parasitica could have a clonal population structure that is generated by asexual reproduction. Low vc-type diversity suggests that the C. parasitica population in the Aydin Mountains may be highly suitable to hypovirus invasion, thereby providing a high potential for successful biological control. However, co-occurrence of sexually compatible strains of EU-1 and EU-12 at the same locations in close proximity creates a high risk of increase in vc-type diversity.
Association between single nucleotide polymorphisms of MUTYH, hOGG1 and NEIL1 genes, and depression

An elevated levels oxidative modified DNA bases and a decreased efficiency of oxidative DNA damage repair were found in patients with depression disorders, including recurrent type (rDD). The glycosylases are involved in base excision repair (BER), which eliminates oxidative DNA damage. Therefore, we genotyped the single nucleotide polymorphisms (SNPs) of genes encoding three glycosylases: hOGG1, MUTYH and NEIL1.We selected three polymorphisms: c.977C > G - hOGG1 (rs1052133), c.972G > C - MUTYH (rs3219489) and c.*589G > C - NEIL1 (rs4462560). A total of 555 DNA samples (257 cases and 298 controls) were genotyped using TaqMan probes.The C/C genotype and allele C of the c.*589G > C decreased the risk of rDD occurrence, while the G/G genotype and allele G of the same SNP increased the risk. This polymorphism had a stronger association with early-onset depression (patients with first episode <35 years of age) than with late-onset depression (first episode ≥ 35 years of age). We did not find any significant differences in distribution of alleles and genotypes of other SNPs; however, the G/G genotype of the c.972G > C increased the risk of late-onset rDD. We also found that combined genotype C/C-C/C of c.977C > G and c.*589G > C significantly reduced the risk of rDD.Limited sample size and ethnic homogeneity of the studied population.This is the first study to show that SNPs of genes involved in DNA repair, particularly in BER pathway, may modulate the risk of rDD. These results further support the hypothesis on the involvement of DNA repair mechanisms in pathogenesis of depression.
Comparative effects of two alkali stresses, Na2CO3 and NaHCO3 on cell ionic balance, osmotic adjustment, pH, photosynthetic pigments and growth in oat (Avena sativa L.).

This study examines the comparative effects of NaHCO3 and Na2CO3 on young oat (Avena sativa L.) plants to elucidate the species’ physiological adaptive mechanisms to alkali stress. Factors considered are the intracellular influx and efflux of ions, ionic balance, osmotic adjustment, pH homeostasis, photosynthetic pigments and growth. Results show that, Na2CO3 had stronger effects than NaHCO3, and that with increasing concentrations of both stresses the plant showed rising Na + influxes into the shoot resulting in Na + ion toxicity. This is tolerated by Na + sequestration in the vacuole; the accumulation mainly of Cl - , SO4 2- and the synthesis of high concentrations of organic anions to maintain vacuolar ionic balance and, lastly by the synthesis of proline in the cytoplasm to avoid dehydration. Moreover, Na2CO3 stress inhibits growth more strongly, compared to NaHCO3, because of the higher energy costs associated with Na + exclusion and compartmentalisation，the syntheses of organic anions, the syntheses of proline in the cytoplasm, reduced photosynthetic capacity and increased membrane permeability. Compared to the shoot, although the root had a similar response to both stresses, it showed a higher tolerance because high Na2CO3 stresses (>48 mmol L -1 ) resulted in significant increases in root tissue pH, but did not affect the pH homeostasis of the shoot. Additionally, while both stresses decreased root dry weight, they did not significantly affect root extension growth. This indicates that oat adopts an opportunistic guerrilla strategy by which it avoids resource-poor patches of soil (e.g. high alkali) while preferentially exploiting more favorable habitats by maintaining root extension.
Technical efficiency and its determinants of the various cropping systems in the purple-soiled, hilly region of southwestern China

This study examines the technical efficiency (TE) differences among typical cropping systems of smallholder farmers in the purple-soiled hilly region of southwestern China. Household-, plot-, and crop- level data and community surveys were conducted to explore TE levels and determinants of typical cropping systems by using a translog stochastic frontier production function. Results indicate significant difference in TE and its determinants among cropping systems. The mean TEs of the rice cropping system (R), the rice-rape cropping system (RR), the rice-rape-potato cropping system (RRP), and the oil cropping system (O) are 0.86, 0.90, 0.84, and 0.85, respectively, which are over 1.17 times higher than those of the maize-sweet potato-other crop cropping system (MSO) and the maize-sweet potato-wheat cropping system (MSW) at 0.78 and 0.69, respectively. Moreover, Technical inefficiency (TIE) of different cropping systems is significantly affected by characteristics of the household as well as plot. However, the impact of land quality, mechanical cultivation conditions, crop structure, farming system, farm radius, household type, cultivated land area per capita, and annual household income per capital on TIE vary by cropping system. Additionally, output elasticity of land, labor, and capital, as a group, is greater than the one of agricultural machinery and irrigation. Finally, when household-owned effective agricultural labor is at full farming capacity, optimal plot sizes for the R, RR, RRP, MSO, MSW, and O cropping systems are 1.12 hm2, 0.35 hm2, 0.25 hm2, 2.82 hm2, 1.87 hm2, and 1.17 hm2, respectively.