SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Suppression of myeloid derived suppressor cells and immune checkpoint blockade

Impressive responses have been observed in patients treated with checkpoint inhibitory anti-PD-1 or anti-CTLA-4 antibodies. However, immunotherapy against poorly immunogenic cancers remains a challenge. Treatment with both anti-PD-1 and anti-CTLA-4 antibodies were unable to eradicate large, modestly immunogenic CT26 tumors or metastatic 4T1 tumors. However, co-treatment with epigenetic modulating drugs and checkpoint inhibitors markedly improved treatment outcomes, curing more than 80% of them. Functional studies revealed that the primary targets of the epigenetic modulators were myeloid-derived suppressor cells (MDSCs). A PI3K-inhibitor that reduced circulating MDSCs also cured 80% of mice with metastatic 4T1 tumors when combined with immune checkpoint inhibitors. Thus, cancers resistant to immune checkpoint blockade can be cured by eliminating MDSCs.
Secure Medical Data Transmission in Body Area Sensor Networks Using Dynamic Biometrics and Steganography

In this paper, we have used ECG signal for secure key exchange between two nodes of the same Body Sensor Network (BSN). InterPulsed Interval (IPI) of the ECG signal is considered as a biometric characteristic for key generation because of its high randomness, time variance properties and also to avoid interference between the other BSNs. The body sensor node to base station (PDA or Laptop) communication has been secured using the symmetric cryptographic algorithm AES and integrity is checked by using the Message Authentication Code (MAC). Steganography is used for securing the data transfer between base station and medical server. In this work, we have embedded the medical data (Blood Pressure) within the patients' facial image. The face image is selected as a cover image in order to provide authentication. The pixel positions for embedding the medical data are determined by fixing a threshold level (120-126). This threshold value is chosen so as to have high random distribution throughout the image. The results have been shown using MATLAB 7.8.0.
Rural Economy and Bioethanol Production

Biofuels are considered part of the potential sources of mitigation for the serious threat of global warming, by reducing human reliance on oil imported from unsafe sources at ever increasing costs. For the classic fuel supplier countries, biofuels are a source for the future, as local materials are used in their production. They generate jobs for the local population and do not require the importation of costly equipment and relevant expertise. A pioneer in the use of biofuels, Brazil has eliminated all oil imports and become energy independent. Recognising the positive effects of biofuel use, the EU and other countries are rapidly developing potential sources of their own biofuels. One of these sources could be agricultural cultures that are able to be developed under optimum conditions by endorsing and using modern and sustainable means and techniques in the rural economy. The sustainable use of the resources and the maintenance of the ecosystems in a good working order claims both the protection of the environment itself and the success of the farmers via the provision of fertility and productivity of the agricultural ecosystems, which will give them the leverage of competitiveness on the market and food safety in the long term. The paper herein intends to point out at a sustainable manner of having the economy’s engine function—i.e., agriculture—by means of advocating for the efficient use of the resources within the farms and their associations, along with the support for the transition to a low-carbon economy, thanks to the progress in the bioethanol production.
DAMPING DEVICE FOR PIECES OF FURNITURE

The damping device (10) comprises a housing body (18) fixable to one of a fixed part (11) or a movable part (12) of the piece of furniture, fluid damping means (23) arranged in said housing body (18), and a driving member (19) operatively connected with said damping means (23); the driving member (19) 5is swingably supported by said housing body (18) and has a contacting portion (21) conformed and arranged in such a way to contact the other of said fixed part (11) or movable part (12) of the piece of furniture at least at a part of a closing or opening movement of the movable furniture part (12), the driving member (19) further having an actuating portion (22) conformed and arranged 10for actuating said fluid damping means (23).
Use of Heliox in the Management of Neonates with Meconium Aspiration Syndrome

Helium-oxygen mixture (heliox) ventilation has been known as an alternative treatment in patients with airway obstruction. Because of the physical properties of heliox, mechanical ventilation with this gas mixture may offer advantages in the management of respiratory failure associated with meconium aspiration syndrome (MAS).The purpose of this pilot study was to assess the effect of short-term mechanical ventilation with heliox in newborns with MAS on vital signs, oxygenation, acid-base balance and respiratory function parameters.The study was carried out in newborns with respiratory failure requiring mechanical ventilation due to MAS. Eight patients were ventilated using pressure-controlled synchronized intermittent mandatory ventilation. Parameters of respiratory function, oxygenation, acid-base balance and vital signs were recorded at baseline, then twice during 1 h of heliox ventilation and finally twice during 1 h after switching back to air-oxygen ventilation.Mechanical ventilation with heliox did not affect vital signs and the infants' clinical condition remained stable during the study. Heliox ventilation was associated with a nonsignificant increase in tidal volume, minute ventilation and peak expiratory flow rate values. Mechanical ventilation with heliox allowed the use of significantly lower FiO(2), with a significant decrease in alveolar-arterial oxygen tension difference and a decrease in the oxygenation index which was not statistically significant. There was also a significant increase in the PaO(2)/FiO(2) ratio during heliox ventilation.Ventilation with a helium and oxygen mixture had a positive effect on the selected parameters of oxygenation, while its effects on other respiratory parameters were relatively small.
Psychosocial support to medical teams in SAMUR-Protection Civile during COVID-19

The COVID-19 pandemic has had an exceptional impact on the health system. The lack of information and resources during the first stage of the outbreak COVID-19 has also meant a change in the way we work and in the way we relate to our relatives, colleagues and, of course, our patients. This traumatic situation, due to its characteristics of total uncertainty, novelty, frequency, and high intensity, made it necessary to develop a new approach to our work, a new psychological approach to the pandemic situation that leads to acute stress, insecurity, unknown consequences, uncertainty about its duration and a desolate future. During the first wave, it was necessary to respond to the new situation. In a first phase, an intervention protocol was created for front-line pre-hospital emergency professionals and a COVID-19 psychological unit was set up in a pandemic hospital in Madrid. In a second phase, emergency actions, their conditioning and possible change due to confinement are analysed; the emotional state of front-line intervention personnel is assessed, comparing the pre- and post-first wave period, and burnout syndrome is studied in the SAMUR-Civil Protection volunteer corps. La pandémie COVID-19 a eu un impact exceptionnel sur le système de santé. Le manque d’informations et de ressources qui ont été ressentis lors du premier état d’alerte COVID-19 a également signifié un changement dans notre façon de travailler et dans notre façon d’être en relation avec nos proches, nos collègues et, bien sûr, nos patients. Cette situation traumatisante, en raison de ses caractéristiques d’incertitude totale, de nouveauté, de fréquence et de haute intensité, a rendu nécessaire le développement d’une nouvelle approche de notre travail, une nouvelle approche psychologique de la situation pandémique qui a conduit à un stress aigu, une insécurité, des conséquences inconnues, une incertitude sur sa durée et un avenir désastreux. Lors de la première vague, il a fallu réagir à la nouvelle situation. Dans une première phase, un protocole d’intervention a été créé pour les professionnels de l’urgence pré-hospitalière de première ligne et une unité psychologique COVID-19 a été mise en place dans un hôpital pandémique de Madrid. Dans une deuxième phase, les actions d’urgence, leur conditionnement et leur éventuel changement dû au confinement sont analysés; l’état émotionnel du personnel d’intervention de première ligne est évalué, en comparant la période précédant et suivant la première vague, et le syndrome d’épuisement professionnel est étudié dans le corps des volontaires de SAMUR-Protection civile.
StrongPinvariance, neutron electric dipole moment, and minimal left-right parity at LHC

In the minimal Left-Right model the choice of left-right symmetry is twofold: either generalized parity $\mathcal P$ or charge conjugation $\mathcal C$. In the minimal model with spontaneously broken strict $\mathcal P$, a large tree-level contribution to strong CP violation can be computed in terms of the spontaneous phase $\alpha$. Searches for the neutron electric dipole moments then constrain the size of $\alpha$. Following the latest update on indirect CP violation in the kaon sector, a bound on $W_R$ mass at $20 \text{TeV}$ is set. Possible ways out of this bound, either by an additional relaxation mechanism or explicit breaking of $\mathcal P$ are considered. To this end, the chiral loop of the neutron electric dipole moment at next-to-leading order is re-computed and provides an estimate of the weak contribution. Combining this constraint with other CP violating observables in the kaon sector allows for $M_{W_R} \gtrsim 3 \text{TeV}$. On the other hand, $\mathcal C$-symmetry is free from such constraints, leaving the right-handed scale within the experimental reach.
Book Review: Steven McFadden’s "The Call of the Land: An Agrarian Primer for the 21st Century"

First paragraph:According to Hinrichs and Lyson (2007), lessons learned from the university and the field are increasingly helping us to participate in a flourishing movement to transform the North American food system. Readers new to this movement sometimes struggle to identify a primer that is accessible and grounded in real-world examples. The Call of the Land: An Agrarian Primer for the 21st Century lends itself as a tool for such readers, as it not only illustrates a foundational agrarian ethos historically argued by Wendell Berry and Wes Jackson, but it also outlines a variety of practical models and approaches to inform the practice of local food system development. For most of the book, McFadden draws upon the lived experiences of various practitioners, farmers, and educators to reveal his agrarian philosophy and subsequent suggestions to better “live with the land” (p. 32). The result is a broad overview of issues affecting the trajectory of food and farming development, and an introduction to several approaches we might take to alter this unsustainable path. McFadden’s ethical stance for agrarian transformation strongly influences these issues and strategies for change.
Modeling and imaging land-cover influences on air temperature in and near Baltimore, MD

Over the course of 1681 hours between May 5 and September 30, 2006, air temperatures measured at the 1.5-m height at seven sites in and near the city of Baltimore, MD were used to empirically model Δ $$ \widehat{T} $$
 R-p
 , the difference in air temperature between a site in downtown Baltimore and the six other sites. Variables in the prediction equation included difference between the downtown reference and each of the other sites in upwind tree cover and impervious cover as obtained from 10-m resolution geographic information system (GIS) data. Other predictor variables included an index of atmospheric stability, topographic indices, wind speed, vapor pressure deficit, and antecedent precipitation. The model was used to map predicted hourly Δ $$ \widehat{T} $$
 R-p
 across the Baltimore region based on hourly weather data from the airport. Despite the numerous sources of variability in the regression modeling, the method produced reasonable map patterns of Δ $$ \widehat{T} $$
 R-p
 that, except for some areas evidently affected by sea breeze from the Chesapeake, closely matched results of mesoscale modeling. Potential applications include predictions of the effect of changing tree cover on air temperature in the area.
Resonant clustering

The extent to which nuclei can comprise lighter nuclear clusters in low-mass systems directly influences astrophysical production and decay rates. However, the scope of clustering away from stability has yet to be fully investigated. This proposal will address this by implementing novel measurement apparatus for exotic clustering in key short-lived isotopes using resonant elastic scattering and at the same time demonstrate an improved spectroscopic tool that can be applied to a wide range of nuclear structure studies. This is possible because of key charged-particle detector expertise of the ER and the Supervisor complementing both the ER's experience in radioactive ion beams and the MC40 cyclotron facility at Birmingham. Birmingham's world-class leadership in clustering and charged-particle spectroscopy make this location an ideal host. The result is a focused proposal that will lead to a flexible tool for extracting precise structure data from radioactive beam experiments, answering questions at the frontiers of nuclear stability, models and nuclear astrophysics. A significant reduction in beam-time required for such investigations will be achieved making the apparatus practical for use at international user facilities while opening more systems to this technique and reducing background.
Expansão e otimização da produção de moldagem por injeção de plástico

A fim de melhor satisfazer as necessidades dos clientes (aumento dos requisitos de peças, novas tecnologias, expansão do portfólio de produtos, etc.), são adquiridas 5 novas máquinas de moldagem por injeção, incluindo periféricos.
Tobacco control policy in France: from war to compromise and collaboration.

BACKGROUND: Absence of an effective tobacco control policy costs lives and tobacco prevention is policy-sensitive. We describe the historical record of tobacco control in France. METHODS: Public policies and main decisions (laws, regulations, health plans) for tobacco control were considered from 1950 to 2010. Data for cigarette sales and relative price of cigarettes were obtained from official databases. Sales are expressed in number of cigarettes. The relative price of cigarettes is the nominal price divided by the Consumer Price Index. RESULTS: The first step Veil Law (1976) blunted the steady increase in cigarette sales observed since World War II. The second period began with the Evin Law (1991). This law banned tobacco advertising and withdrew tobacco from the Consumer Price Index allowing for marked and repeated increases in taxes. Sales decreased over the next 6 years, from 97.1 billion to 83.0 billion in 1997 but then remained steady for 5 years (83.5 billion in 2001). The first Cancer Plan (2003) imposed three tax increases in a year (39% increase in price). Cigarette sales decreased to 54.9 billion in 2004. This period ended in 2004 when a moratorium on tobacco taxes was announced. The policies which have been implemented since President Sarkozy was elected in 2007 were flawed and protected the interests of the tobacco industry: prevalence of smoking is now increasing, mainly among the younger generation. Since 1991, the cigarette market has nearly halved but the decline has been a stop-and-go erratic process. The two 5-year periods (1997-2002 and 2005 -2010) during which consumption leveled off seem to demonstrate that government-driven health policies could have been influenced by commercial interests. CONCLUSION: Tobacco control efforts, especially tobacco tax increases, need to be sustained and shielded from the influence of the tobacco industry.
Workpiece and Machine Design in Additive Manufacturing for Multi-Axis Fused Deposition Modeling

Abstract Additive Manufacturing (AM) technologies require innovative design paradigms and guidelines that exhaust the offered freedoms in geometry and material. The aim of the Design for Additive Manufacturing is to provide design opportunities and to enhance workpiece properties taking into account constraints of the process, e.g. kinematics and limitations of print technology. Most AM applications are constrained to three-axis movements limiting the fabrication of workpieces layer by layer to one fixed building direction only. This causes limitations of strength properties, surface quality and the need of supporting structures. Multi-axis AM enables completely new design possibilities going beyond current optimization and design strategies of conventional AM workpieces. This innovation requires multiple design and manufacturing changes in the internal and external geometry of the workpiece as well as in machine and printing head technology. This paper identifies the requirements and capabilities of multi-axis AM and presents possible solutions to overcome the identified challenges. Preliminary results for multi-axis AM are described on an exemplary workpiece.
The neglected pillar of recovery : a study of higher education in post-war Iraq and Libya

This thesis argues that higher education systems in post-conflict states have the potential to contribute towards more effective post-war reconstruction and recovery. However, while the role of Higher Education in Development was emphasised in the post-WWII era, the specific experience of higher education in post-conflict contexts has escaped the attention of both academics and policy-makers engaged in reconstruction. Furthermore, donor policy attention has not been placed upon utilising the resources of higher education in post-war recovery. The overall aim is therefore to address this gap in the literature by providing global analysis of higher education in post-war recovery. Firstly, a theoretical framework of the relationship between higher education and recovery was constructed in terms of the functions that higher education can perform in contributing to recovery, the features of the post-war environment that hinder or enable higher education, and various policy options available to post-conflict higher education. Secondly, two case-studies of Iraq and Libya were examined to explore the relationship between higher education and post-war recovery. Principally through interviews with academics and policy-makers from case-study countries, the thesis reveals a range of perspectives and voices on higher education during post-conflict recovery and transition. The thesis concludes that higher education should be conceptualised as an important pillar of recovery; the capacity of domestic higher education sectors in post-conflict contexts is an often under-recognised and under-utilised resource of considerable potential value that can connect to a wide range of reconstruction and recovery processes and effectively drive post-conflict recovery and transitions. Given the under-theorised and under-studied nature of higher education and post-conflict recovery the thesis operates in a theory-building mode and offers what is to date the first attempt to construct a global theorisation.
Subvention du fonds de roulement pour Katarzyna Kapek «Dans l’arbre gravé»

Le projet vise à aider l’entreprise à fournir des liquidités et à soutenir ses activités quotidiennes en raison de difficultés financières survenues dans l’entreprise à la suite de la pandémie de COVID-19. Assistance financière fournie sur la base du régime SA.57015.
The interdisciplinary magazine 

The current project’s objective is a wider dissemination of the economic and technical-scientific culture concerning highly interdisciplinary issues, such as those involving Agribusiness (i.e the industry of agricultural products and services), Environment and Landscape. This dissemination is carried out in first place thanks to a powerful tool: the international interdisciplinary magazine Agribusiness Paesaggio & Ambiente (Agribusiness Landscape & Environment Management), which is a proper training ground for a discussion on these themes. The magazine aims at providing an updating tool and at disseminating knowledge about the results of the new research carried out in the field of territory, landscape, environment and agriculture, in a framework of sustainable development. Moreover, the task is made easier by the regular updating of the magazine web site and the multimedia links. The initiative begins with the setting up of a database contaning the mailing list of Italian and Slovenian addressees, and the transformation of the web sites belonging to the magazine, to CISAPA and to the Friuli Venezia Giulia Ecoinstitute, which is now bilingual: Italian version (already existing) and Slovenian (a new creation). A further dissemination of the economic, technical and scientific culture will thus be possible. In a later stage a “call for papers” in Slovene is carried out; it will be communicated to teachers and researchers of the Slovenian universities (including their branches), asking for technical-scientific contributions (articles) to be sent to the magazine and to the planned symposium. During the two years of the project, in the Agribusiness Landscape & Environment Management issues the Italian text will be integrated by Extended Abstracts in Slovene. Two CD containing the papers presented at the symposiums will be sent to all the addressees.
Impacts of trade related sustainability strategies on freight transportation: Modelling framework and application for France

Abstract The circular and functional economies are being presented in the literature as potential strategies for future sustainable societies. In terms of the consequences for supply chains, they will promote a much more dispersed and diversified, local and network based usage of goods than the current economy, which is comparatively linear, concentrated, long distance oriented and scale economy based. A gap in the literature is the assessment of the effects of these systems on freight transport flows. In our paper, we present a first attempt at estimating this impact using freight transport scenario building and quantitative modelling. In order to translate the main parameters that characterize these systems into factors determining freight transportation volumes, we develop a framework based on a typology of goods categories describing functional and spatial proximity between producers and consumers. In order to simulate changes in the economy, we develop scenarios for the shifting of goods from one category to another and, additionally, include internalization policies that should guide their realization. We calculate the impacts on freight flows using a new interregional transport model for France that includes distribution chains and produces estimates of external costs of transport. Our results show that circular and functional economies could lead to a 2–5% reduction of air pollutant emissions and up to a 14–26% reduction if combined with the internalization of external costs. The scenario with ongoing mass production for differentiated demand is found to lead to a 5% increase of environmental impacts compared to the baseline.