SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Dissymmetric Bis(dipyrrinato)zinc(II) Complexes: Rich Variety and Bright Red to Near-Infrared Luminescence with a Large Pseudo-Stokes Shift

Bis(dipyrrinato)metal(II) and tris(dipyrrinato)metal(III) complexes have been regarded as much less useful luminophores than their boron difluoride counterparts (4,4-difluoro-4-bora-3a,4a-diaza-s-indacenes, BODIPYs), especially in polar solvent. We proposed previously that dissymmetry in such metal complexes (i.e., two different dipyrrinato ligands in one molecule) improves their fluorescence quantum efficiencies. In this work, we demonstrate the universality and utility of our methodology by synthesizing eight new dissymmetric bis(dipyrrinato)zinc(II) complexes and comparing them with corresponding symmetric complexes. Single-crystal X-ray diffraction analysis, (1)H and (13)C NMR spectroscopy, and high-resolution mass spectrometry confirm the retention of dissymmetry in both solution and solid states. The dissymmetric complexes all show greater photoluminescence (PL) quantum yields (ϕPL) than the corresponding symmetric complexes, allowing red to near-infrared emissions with large pseudo-Stokes shifts. The best performance achieves a maximum PL wavelength of 671 nm, a pseudo-Stokes shift of 5400 cm(-1), and ϕPL of 0.62-0.72 in toluene (dielectric constant εs = 2.4), dichloromethane (εs = 9.1), acetone (εs = 21.4), and ethanol (εs = 24.3). The large pseudo-Stokes shift is distinctive considering BODIPYs with small Stokes shifts (∼500 cm(-1)), and the ϕPL values are higher than or comparable to those of BODIPYs fluorescing at similar wavelengths. Electrochemistry and density functional theory calculations illustrate that frontier orbital ordering in the dissymmetric complexes meets the condition for efficient PL proposed in our theory.
Evolution of cell fate decision during development

During development cells progressively acquire specific features that result in the definition of cellular fates.Inter- and intra-specific homologous cell lineages show significant variation in the adoption of particular cell fates. Yet, at present the genetic and molecular mechanisms underlying these intra-specific changes in cell fate and how variation in cell fates is biased during evolutionary trajectories are largely unknown. In this project I will use the vulva system in genetically tractable nematodes to i)identify the molecular basis of intraspecific cell fate variation and ii)to investigate whether evolutionary trajectories in cell fate variation are developmentally constrained in distinct nematode genera. In Caenorhabditis species, among the six ""vulva precursor cells"", only one termed P3.p shows fate evolution within and among species.In contrast,in Oscheius species(sister genus)other vulva precursor cells fates evolve faster, named P4.p and P8.p.  The work is structured into two main objectives. First,I will investigate the molecular and genetic basis of intraspecific P3.p cell fate variation in C.elegans using quantitative genetics, whole-genome sequencing and modern genome editing techniques. Second,I will probe the role of developmental constrains in biasing evolutionary trends of cell fate variation by using a combination of random mutagenesis and quantitative genetics.This project will contribute to integrate the field of evolution of development with a population and quantitative genetic framework and will provide a mechanistic genetic understanding of cell fate variation during development and evolution at several evolutionary scales. Based on a highly successful research group in a worldwide-recognized institute and its network of collaborators,it will allow me to obtain a strong background in evolutionary theory,nematode development,genome bioinformatic skills and quantitative genetics,building on my strong molecular and developmental background
BATTERIES HAVING COILED ELECTRODE PLATE GROUP

A battery (100) comprises a coiled electrode plate group which comprises a positive electrode plate (120), a negative electrode (130) plate and an insulating separator sheet (140). The separator sheet (140) provides electrical insulation between the positive and negative plates (120, 130). The insulating separator sheet (140) comprises a first longitudinal portion, a second longitudinal portion and a intermediate perforated portion (148) between the first and second longitudinal portions.
Mediterranean Forum For Applied Ecosystem-Based Management

The actual mainstreaming of Ecosystem-Based Management (EBM) in Integrated Coastal Zone Management (ICZM) is still limited mainly because the practical application of EBM is a challenging task for ICZM actors. The MED4EBM project will tackle this issue by assisting ICZM actors in four coastal areas of Jordan, Italy, Lebanon and Tunisia to jointly develop and apply a common methodology to make ecosystem-based ICZM much easier to design and implement by applying innovative techniques and methods. A software tool will help institutional actors to better handle the complex multi-stakeholders analytical processes that characterize EBM applications and assess the relationships between ecosystem components, functions and services, as well as the associated human activities. Moreover, the project will provide government officials and managers with the necessary tools, skills and competences to develop and implement ecosystem approaches to the management of activities in the marine and coastal environments.
Advancing tools for human early lifecourse exposome research and translation

ATHLETE aims to develop a toolbox of advanced, next-generation, exposome tools and a prospective exposome cohort, which will be used to systematically quantify the effects of a wide range of community-level and individual-level environmental risk factors on mental, cardiometabolic, and respiratory health outcomes and associated biological pathways during the first 2 decades of life, to implement acceptable and feasible exposome interventions, and to translate the resulting evidence to policy recommendations and prevention strategies.
ATHLETE will establish a prospective exposome cohort, including FAIR data infrastructure, building on Europe’s most comprehensive already existing exposome data (15 cohorts in 10 European countries). ATHLETE will systematically characterise the effects of the exposome on early organ development, health trajectories, and biological pathways (metagenomic, metabolomic, epigenetic, ageing, and stress pathways), longitudinally from early pregnancy through adolescence. Innovative tool development will focus on: 1) complete and accurate measurement of multiple environmental risk factors (external/urban, chemical, physical, behavioural, social) through new targeted and untargeted exposure science approaches, 2) development of advanced statistical and toxicological strategies to analyse complex multi-dimensional exposome data, 3) development of interventions to reduce personal exposures, co-produced with the community, and 4) estimation of the societal impact of the exposome by calculating costs and child health impacts.
ATHLETE’s strong focus on the vulnerable early stages of the life course, widespread general population exposures and common non-communicable diseases, its use of a large body of existing exposome data and expertise, its strong emphasis on knowledge translation, its development of an open online toolbox and its close collaboration in the European Human Exposome Network ensure that the objectives are achievable and highly relevant for future research and policy.
ATHLETE is part of the European Human Exposome Network comprised of 9 projects selected from this same call.
Basic and Applied Bone Biology

This book provides an overview of skeletal biology from the molecular level to the organ level, including cellular control, interaction and response; adaptive responses to various external stimuli; the interaction of the skeletal system with other metabolic processes in the body; and the effect of various disease processes on the skeleton. The book also includes chapters that address how the skeleton can be evaluated through the use of various imaging technologies, biomechanical testing, histomorphometric analysis, and the use of genetically modified animal models. It presents an in-depth overview of skeletal biology from the molecular to the organ level. It offers refresher level content for clinicians or researchers outside their areas of expertise. It boasts editors and many chapter authors from Indiana and Purdue Universities, two of the broadest and deepest programs in skeletal biology in the US; other chapter authors include clinician scientists from pharmaceutical companies that apply the basics of bone biology.
P. FRANZINA. Introduzione al diritto internazionale privato

Este artículo reseña: P. Franzina. Introduzione al diritto internazionale privato. Giappichelli Editore,Torino, 2021, 336 pp. ISBN 9788892142237
Subjective states associated with retrieval failures in Parkinson’s disease

Instances in which we cannot retrieve information immediately but know that the information might be retrieved later are subjective states that accompany retrieval failure. These are expressed in feeling-of-knowing (FOK) and Tip-of-the-tongue (TOT) experiences. In Experiment 1, participants with Parkinson's disease (PD) and older adult controls were given general questions and asked to report when they experienced a TOT state and to give related information about the missing word. The PD group experienced similar levels of TOTs but provided less correct peripheral information related to the target when in a TOT state. In Experiment 2, participants were given a Semantic (general knowledge questions) and an Episodic (word pairs) FOK task. PD patients failed to accurately predict their future memory performance (FOK) in response to both episodic and semantic cues. Results are interpreted in the context of recent frameworks of memory and metacognition.
More to see than a canvas in a white cube: For an art in the streets

Graffiti art is neither ‘simply graffiti’ nor ‘simply art’, but a new kind of visual cultural production that exceeds both categories. Graffiti art moved beyond the neo‐dada/pop art strains of (post)modern (galleried) painting and took the next dialectical step, out into the streets: no longer paintings on canvas that mimic the image‐strewn city walls, but the city walls themselves as the canvas for new image‐making. Street art has read the signs of this historic move correctly, and has followed graffiti art in ‘taking place’ in the public sphere of the public square. These new art forms are an enhancement to contemporary urban living, a welcome growth in the living city, a disruption of the unexamined assumptions connecting urban visual culture and the existing social order. Another art city is now possible if the art in the street is taken seriously.
Entwicklung und Umsetzung innovativer Technologien im Bereich Laminierung, Schneiden und Schneiden von umweltfreundlichen Verpackungsmaterialien

‚Numer_reference_aid_Programm: SA.42799(2015/X), für öffentliche Beihilfen bestimmt: Artikel 28 der Verordnung (EU) Nr. 651/2014 der Kommission" Gegenstand des Projekts ist die Bereitstellung innovativer Beratungsdienste durch ein akkreditiertes Innovationszentrum für den Antragsteller zur Umsetzung von Produkt-, Prozess-, Organisations- und Marketinginnovationen. Als Ergebnis des Projekts ist geplant, die Produktionskapazität des Unternehmens auf Basis innovativer technologischer Lösungen zu erhöhen, die in gekauften Sachanlagen und Software verwendet werden. Im Zusammenhang mit der Durchführung des Projekts ist geplant, folgende Ziele zu erreichen: — Implementierung innovativer Lösungen im Bereich der Technologie, des Produkts und der Organisation der Prozesse innerhalb des Unternehmens, – erhöhen Sie die Wettbewerbsfähigkeit des Unternehmens sowohl auf dem inländischen als auch auf dem ausländischen Markt, – erhöhen Sie die Einnahmen des Unternehmens, – erhöhen Sie die Qualität, Haltbarkeit und Ästhetik der hergestellten Produkte, – Aufrechterhaltung der Aktualität der Aufträge, – Einsparung von Rohstoffen und Energie im Zusammenhang mit dem Kauf innovativer Maschinen. Zu den für das Projekt geplanten Einzelaktivitäten, die für die Umsetzung der Technologie und den Beginn der Produktion neuer Produkte erforderlich sind, gehören der Kauf von Maschinen und Ausrüstungen zum Schneiden, Verpacken und Formen von Verpackungsfolien, um die Produktion aufzunehmen, die unmittelbar nach Beginn des technologischen Prozesses möglich sein wird.
Living with falls: house-bound older people’s experiences of health and community care

Despite world-wide emphasis on falls prevention, falls and their consequences remain a major health issue for older people, and their health care providers. Many systematic reviews have been undertaken to evaluate the impact of intervention programmes on falls reduction, however, relatively little research provides a voice for older people's own perceptions of such programmes. To readdress this imbalance the current research utilized a purposive sampling method to recruit a hard to reach group of older people who had received a post-fall health and social-care programme to investigate their experiences of the programme. Semi-structured interviews with eight housebound people aged over 65 who had fallen were undertaken, and data analysed using interpretative phenomenological analysis. Four themes were identified: losing independence; losing confidence; losing social identity; managing a changed self. Despite a tailored intervention programme minimal improvement in participants' psychological adjustment to falls was noted. Outcomes from this study are of interest to health and social-care staff who deliver falls prevention programmes. Staff need to enhance constructive adjustment to the older person's altered circumstances and ensure behaviours do not exacerbate their clients' loss of independence. This should assist older people's ability to positively manage their sense of self, allowing them to find continuing meaning in their daily lives.
A novel polyrotaxane-based delivery system for scutellarin: preparation, characterization, and in vitro evaluation

The safe and effective polyrotaxane-based drug delivery system could potentially increase the antiproliferative activity of antitumor medicine. A novel scutellarin-polyrotaxane (SCU-PR), in which scutellarin (SCU) was covalently bound to one of the hydroxyl groups of polyrotaxane (PR), was synthesized, and its characterization was further investigated by NMR, XRD, TG, DSC. The cytotoxicity of SCU-PR was assessed in vitro using human HCT116 and LOVO cell lines in results that the IC50 values of SCU-PR (1.03×10(-6) and 1.01×10(-6)mol/L, respectively), which compared with those of free SCU (7.80×10(-5) and 7.70×10(-5)mol/L, respectively), were lower. The valuable properties of SCU-PR will be potentially useful for its application on human colon cancer chemotherapies.
Monetary policy, heterogeneity, and the housing channel

The Great Recession has brought to light the importance of housing and household debt for the propagation of shocks in the macroeconomy. For a majority of households, owner-occupied housing represents the single most important asset in the household portfolio and is tied to the single largest liability—the mortgage. The broad objective of this project is to investigate the rich role that housing and nominal mortgage borrowing jointly play in the transmission of monetary policy.  First, monetary policy induced-movements in house prices translate into consumption changes because of wealth effects. Second, a contractionary monetary shock raises the cost of borrowing which reduces the demand and as a result the liquidity of the housing market, further depressing house prices and further increases the cost of borrowing. Furthermore, nominal long-term mortgage debt implies that changes in monetary policy result in redistribution between lenders and borrowers and generate cash-flow effects that are larger for borrowing constrained households. In order to quantify these various mechanisms, we build a heterogenous agent New Keynesian (HANK) model with a frictional housing market and nominal mortgage debt.  The model will be able to match the rich empirical heterogeneity in home ownership, leverage and marginal propensity to consume (MPC) across households. In particular, we aim to match the significant difference in MPC between highly leveraged households and less-leveraged ones that we document in the data.  We will then use the model to answer the following questions:  Is there any asymmetry between contractionary and expansionary monetary policy responses? Does effectiveness of the policy depend on the distribution of mortgage debt? How to manage a liquidity trap induced by a housing bust?
Enhance new approaches in biobased local innovation networks for growth

ENABLING is the initiative of 16 partners in 13 EU and associated (IL, NO) countries. The main goal is to support the spreading of best practices and innovation in the provision (production, pre-processing) of biomass for the BBI (Bio-Based Industry). In particular, ENABLING aims at creating appropriate conditions for the development of efficient biomass to BBPs (Bio-Based Products and Processes) value chains. The consortium’s vision is that Europe bears a huge potential for optimising the supply of biomass into innovative bio-based processes and products. Upscaling biomass production and pre-processing, and combining streams towards the BBPs with those of more traditional bioenergy chains would enhance at least three interlinked types of impact. a) biomass production gains scale to meet higher demand in both sectors (bioenergy and the BBI); b) the reinforcement of biomass supply for the BBI benefits smaller BBI players, helping them diversify and consolidate biomass input sources; c) reinforcing the biomass and BBPs linkages may contribute to job-creation, due to the increased need for specialised workers. To realise such potential, ENABLING also anticipates its longer term exploitation pathways. In the intention of the consortium, the project should aggregate and engage partners for the establishment of a permanent innovation brokerage platform, likely to become in the future, one of the main marketplaces and innovation transfer accelerators at European level. In this sense, the project organises its work around two building blocks: one relates to animating the stakeholders (on the farming and BBPs sides), identifying best practices, turning them into easy to access content (in the EIP format) for their potential users and providing stakeholders with coaching and guidance on innovation. The other one looks at future developments, with the consolidation, in a self-sustainable way, of the innovation brokerage platforms after the end of the EU funded initiative.
BICOMPONENT FIBERS AND METHODS FOR MAKING THEM

The present invention relates to bicomponent polymer fibers, and to processes for forming those fibers. Bicomponent polymer fibers are described, having a core comprising a core polymer and a sheath comprising a sheath polymer, wherein the sheath polymer is a polyolefm having an Mw less than about 65,000 g/mol. The core polymer has an Mw at least about 20,000 g/mol greater than the Mw of the sheath polymer. Processes for forming bicomponent fibers are also described, comprising (i) forming a molten blend of a core polymer and a sheath polymer; (ii) extruding the molten polymer blend using an extrusion die having a length to diameter ratio greater than or equal to about 10 and under shear conditions sufficient to drive the sheath polymer to the die wall; and (iii) forming meltblown fibers having a core comprising the core polymer and a sheath comprising the sheath polymer.
A novel wearable, cost-effective and non-invasive biometric body worn video solution for accurate and high throughput screening of people, bags and vehicles

AUDAX Global Solutions Ltd. is an SME founded in Plymouth UK in 2005. Since then it has become a pioneer in the delivery
and development of mobile digital evidence gathering products and services. The AUDAX team consists of the most
knowledgeable experts in the industry who are committed to offer groundbreaking innovative solutions. AUDAX owns a new
technology Bio-AX™, a unique, wearable and non-intrusive biometric body worn video system that can screen people, bags
with high throughput and high accuracy. This technology will bring many benefits to the stakeholders and increase security
in our communities. AUDAX sees a huge business opportunity through sales. The uniqueness of Bio-AX™ will increase the
Unique Selling Proposition (USP) of our products and competitive advantage in the market. AUDAX have passed Feasibility
Study and Customer Development, and believe that Bio-AX™ will raise the Company’s profitability and grow its workforce.
The project is feasible, viable, profitable and sustainable. AUDAX is seeking financing through SME Instrument to fund the
transition of the TRL6 prototype into commercialisation.
Increasing the Depth of Current Understanding: Sensitivity Testing of Deep-Sea Larval Dispersal Models for Ecologists

Larval dispersal is an important ecological process of great interest to conservation and the establishment of marine protected areas. Increasing numbers of studies are turning to biophysical models to simulate dispersal patterns, including in the deep-sea, but for many ecologists unassisted by a physical oceanographer, a model can present as a black box. Sensitivity testing offers a means to test the models' abilities and limitations and is a starting point for all modelling efforts. The aim of this study is to illustrate a sensitivity testing process for the unassisted ecologist, through a deep-sea case study example, and demonstrate how sensitivity testing can be used to determine optimal model settings, assess model adequacy, and inform ecological interpretation of model outputs. Five input parameters are tested (timestep of particle simulator (TS), horizontal (HS) and vertical separation (VS) of release points, release frequency (RF), and temporal range (TR) of simulations) using a commonly employed pairing of models. The procedures used are relevant to all marine larval dispersal models. It is shown how the results of these tests can inform the future set up and interpretation of ecological studies in this area. For example, an optimal arrangement of release locations spanning a release area could be deduced; the increased depth range spanned in deep-sea studies may necessitate the stratification of dispersal simulations with different numbers of release locations at different depths; no fewer than 52 releases per year should be used unless biologically informed; three years of simulations chosen based on climatic extremes may provide results with 90% similarity to five years of simulation; and this model setup is not appropriate for simulating rare dispersal events. A step-by-step process, summarising advice on the sensitivity testing procedure, is provided to inform all future unassisted ecologists looking to run a larval dispersal simulation.