SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Epidemiological investigation for hypertension prevalence and analysis of farmers and herders over 45 years old in Duilongdeqing County of Tibet,China

Objective To analyze the prevalence rate of hypertension among the farmers and herders over 45 years of age in Duilongdeqing county of Tibet,China.Methods Random sampling survey was conducted among 1 350 farmers and herders aged 45 above in Tibet.The investigation included questionnaire and medical examination of blood pressure,body weight,height,etc.Results The prevalence of hypertension was 45.77%,and the rates of awareness,treatment and control of hypertension were 26.21%,22.29% and 2.75%,respectively.the awareness rate and the treatment rate were increased with age(P0.05).The main effect factors on the rates of awareness,treatment and control of hypertension were age,family history,body mass index and sex.Conclusion The prevalence of the hypertension in the county might be higher than the national prevalence.Most of the patients with hypertension were unaware of their disease and had not been treated with anti-hypertensive medications.
Elucidation of intratumoral heterogeneity in kras-driven cancers

The considerable variability within tissue microenvironments as well as the multiclonality of cancers leads to intratumoral heterogeneity. This increases the probablility of cellular states that promote resistance to therapy and eventually lead to reconstitution of the tumor by treatment-resistant cancer cells, which in some cases have properties of normal tissue stem cells. Wnt signals are important in the maintenance of stem cells in various epithelial tissues, including in lung development and regeneration. We hypothesized that Wnt signals contribute to tumor heterogeneity in genetically engineered KrasG12D; Tp53Δ/Δ (”KP”) mouse lung adenocarcinomas (LUAD). We observed that a subpopulation of LUAD cells exhibited high Wnt reporter activity and had increased tumor forming ability, which could be suppressed by silencing of Wnt signaling pathway components or by small molecule Wnt inhibitors in vitro and in vivo. KP LUAD cells show hierarchical features with two distinct populations, one with increased Wnt reporter activity and another forming a niche that provides the Wnt signal. Lineage-tracing experiments in the autochthonous KP tumors demonstrated that Wnt responder cells have increased tumor propagation ability in vivo. Strikingly, selective ablation of the Wnt responder cells resulted in tumor stasis. CRISPR-based targeting or small molecules targeting Wnt signaling reduced tumor growth and prolonged survival in the autochthonous KP mouse lung cancer model. These results indicate that maintenance of heterogeneity within tumors may be advantageous for the tumor cell population collectively. We propose to elucidate the molecular and cellullar mechanisms that control stem-like and niche cell phenotypes using a combination of novel lentiviral vectors and genetically modified mice in the context of the KP LUAD model. These efforts may lead to novel therapeutic concepts in human lung cancer.
Adaptar las unidades de producción a la nueva realidad post-Covid-19

Observar o Futuro Lda, es una empresa dedicada al diseño y operación de albergues, apartamentos y cuenta simultáneamente con tours. Queremos preparar y adaptar nuestras unidades a la operación después de Pandemia Covid-19, con el fin de minimizar los riesgos para los clientes y los trabajadores.
Gas sensing in plants: oxygen- and nitric oxide-regulated chromatin modification via a targeted protein degradation mechanism

Oxygen (O2) and nitric oxide (NO) are gases that function as key developmental and stress-associated signals in plants. Investigating the molecular basis of their perception has the potential to identify new targets for crop improvement.  In previous ground breaking work I showed that the direct transcriptional response to O2/NO is mediated by controlled degradation of specialised ‘gas-sensing’ transcription factors. We have now linked this degradation mechanism to a new functional class of ‘sensor’, a chromatin modifying protein that regulates the epigenetic silencing of genes. Here we will investigate the hypothesis that this protein acts as a previously undiscovered link between O2/NO and chromatin dynamics, and that plants have evolved a unique system for transducing gaseous signals into rapid transcriptional responses, and longer term epigenetic changes, through targeting different types of protein to the same degradation pathway.  
Using multidisciplinary genetic, biochemical and omics approaches we will investigate the molecular basis of this novel gas perception system, which appears to be a plant-specific innovation. We will identify its global gene targets (the ‘gas-responsive epigenome’), and uncover its growth and stress-associated functions in Arabidopsis and barley. We will also investigate how manipulating this pathway using genome editing and synthetic biology techniques alters plant performance, focusing on traits of agronomic significance.  This ambitious and timely research will take our knowledge of O2/NO-signaling and the control of chromatin dynamics beyond the current state of the art by offering insight into a completely novel signaling mechanism operating at the interface of gas-perception, protein degradation, and epigenetics. GasPlaNt will therefore provide a step-change in our understanding of how plants synchronise their gene expression in response to signals to optimise growth and development within a dynamic environment.
Design for manufacturing of surfaces to improve accuracy in Fused Deposition Modeling

Fused Deposition Modeling is an Additive Manufacturing technology able to fabricate prototypes, tooling and functional parts without geometrical complexity limitations. Despite of the potential advantages of this technology, a limiting aspect of its industrial diffusion is the obtainable accuracy. The literature highlighted that significant deviations from the nominal values are observed: these deviations are not constant over all the part surfaces but strictly depend upon the process parameters, i.e. the layer thickness and the deposition angle. This involves poor surface quality: the parts could not satisfy the design specifications nor assure the functionality and the assembly fit with other components. The aim of this work is the development of a design for manufacturing methodology able to improve the dimensional accuracy obtainable by this technology. It operates in the design model step performing a virtual model preprocessing: an anisotropic offset is applied to the surfaces, defined by a mathematical formulation, in order to compensate for the abovementioned dimensional deviations. This way, without to eliminate the physical sources of the errors, it is possible to obtain a part with dimensional values very close to nominal ones. This method does not require any additional resources for its application such as preliminary artifact construction and measurements. A design for manufacturing to improve FDM part accuracy is proposed.A redesign of the solid allows compensating for the dimensional deviation.The model surfaces are modified by means of an anisotropic offset.The proposed method is applied to parts defined by a mathematical formulation.The method is validated through the application to three mechanical components.
Cost-Effective  high-efficiency smart steam boiler of low emission technology

With EcoVapor, we offer a smart steam boiler that will make steam production a very cost-effective (ca. 30-50% cheaper than typical 3-pass boilers of low NOx emissions), energy-efficient (up to 95% overall), smart (custom-designed based on specific needs for the industry which operates at different powers within a large modulation range (5-100%)), and environmentally friendly alternative (only 80mgNOx/kWh emissions able to comply with the most stringent regulations) to appeal to market segments that want to foster the uptake of new steam-generating technologies to reduce energy bills, optimise energy consumption, and reduce NOx emissions. 
Our company, ICI Caldaie, has partnered with Burnertech - a UK based engineering company specialised in design and manufacturing of tailored solutions for burner design – Troll System - an Italian company with more than 20 years expertise in custom-designed products of the electronic market - and CTIC-CITA - a Spanish cluster of companies of the F&B sector, to exploit €69.44 million accumulated revenues (by 2022) business opportunity. 
EcoVapor has been developed integrating a low NOx pre-mix burner developed by ICI based on the combustion head of Burnertech (patent application: WO2014167270 (A1)), and an e-term® PCB control electronics from Troll.
We plan to penetrate initially the EU F&B industry by mid-2018 in countries coinciding with ICI highest volume of sales (Italy, Spain, UK, France, Poland, and Romania), and then, other industries starting from 2019 (i.e. textile, tanning, chemical, and pharmaceutical) in EU and non-EU countries we already have a consolidated presence (Serbia, Ukraine, Russia, and Kazakhstan) along with US and Canada by 2020, through direct contact of our current sales force.
Synthesis of Active Cell Balancing Architectures for Battery Packs

Active balancing architectures effectively increase the efficiency of large battery packs by equalizing charge between cells. For this purpose, a balancing circuit and appropriate control scheme have to be designed to enable the charge transfer via energy storage elements such as inductors. Using a manual approach to design balancing architectures can be tedious and error-prone, resulting in potentially suboptimal solutions. As a remedy, this paper presents an automatic synthesis of balancing circuits and their corresponding control, optimizing the number of required metal-oxide-semiconductor field-effect transistors, and necessary control signals. The proposed synthesis combines a satisfiability solver to explore the search space with a graph-based verification that iteratively excludes infeasible solutions until the optimal architectures are obtained. The experimental results are carried out for three given template circuits and two signal templates. The synthesis results in architectures that are superior in terms of all design objectives in comparison to solutions from literature that result from a manual design approach.
RAPID SCREENING, THRESHOLD, AND DIAGNOSTIC TESTS FOR EVALUATION OF HEARING

A rapid screening, threshold, and diagnostic tests for evaluation of hearing includes techniques that are particularly suited for rapid objective hearing screening and evaluation of newborns or other patients who are unable or unwilling to provide reliable subjective responses. The hearing tests may be frequency specific or may evaluate overall hearing ability without special focus on frequency-specific loss. The tests involve the use of novel stimuli, signal processing, signal analysis, and statistical techniques, including the use of ramped stimuli and evaluating the changes that these stimuli evoke in the individual's brain activity at different moments in time.
Optimal strategies to retain and re-use water and nutrients in small agricultural catchments across different soil-climatic regions in europe

Natural/Small Water Retention Measures (NSWRMs) can help mitigate the conflicts between agricultural water uses (e.g. plant production, animals) and other human and environmental demands for water, including drinking water or maintaining environmental flow. This is crucial, since these conflicts will be probably exacerbated by an increasing number of extreme events such as droughts and heavy rainfall. A more careful management of head watersheds will significantly contribute to a more resilient agriculture and society. Moreover, NSWRMs are contributing simultaneously to the achievement of different Sustainable Development Goals and environmental targets formulated in several water- and agriculture-related European Union policies. Despite a comprehensive set of techniques available to increase water retention on both catchment and farm levels, knowledge is still lacking on the effectiveness of different scale- and region-specific measures across various soil-climatic regions and agricultural systems, especially under changing climate conditions. OPTAIN aims to (i) identify efficient techniques for the retention and reuse of water and nutrients in small agricultural catchments across Continental, Pannonian and Boreal biogeographical regions of Europe, taking into account potential synergies with existing drainage-irrigation systems, and - in close cooperation with local actors - (ii) select NSWRMs at farm and catchment level and optimize their spatial allocation and combination, based on environmental and economic sustainability indicators. By building on existing knowledge and addressing these objectives, OPTAIN will improve the Technological Readiness Level of NSWRMs for the benefit of both humans and ecosystems. All gained knowledge will be translated into a learning environment allowing analysis of trade-offs and synergies between multiple values/goals in the management and design of NSWRMs.
Dietary Influence of Amino Acids on Growth of Neon tetraParacheirodon innesi

A study was conducted to determine the effect of dietary amino acids on the growth performance of neon tetra (Paracheirodon innesi). Eleven purified diets were prepared using crystalline amino acids, and their effects on growth, survival and feed performance of P. innesi (0.0506±0.001 g mean initial weight) were evaluated. Control diet contained all ten essential amino acids, while in other diets one essential amino acid was deleted and that amino acid was replaced with alanine. Fishes were fed by hand to apparent satiation, twice a day, for 90d. Fish fed with the control diet resulted in the highest weight gain, specific growth rate, food conversion efficiency and protein efficiency ratio and it differed significantly (P<0.05) with other diets. This indicated that all ten amino acids were found essential for growth of P. innesi. Lowest growth was observed in lysine, arginine, leucine, valine and threonine deficient diets. From the growth data, it was evident that the growth rate reduced in absence of each of the chosen amino acids and it thus proved that they were more essential for this species. It is concluded that appropriate and balanced incorporation of each amino acid in the diet of P. innesi is necessary for the efficient feed utilization and better growth for its mass production.
How can that which is beyond articulation be articulated? constructions of belief through doubt and faith.

The question that began this research is a question about belief. It is primarily a question about form and forming that which cannot be articulated. Within this research belief has been defined as not-knowledge. Belief is oppositional to knowledge. It requires an action towards an outside of knowledge. It is absurd. Knowledge bases itself on measurable and quantifiable sets of reasoning. Belief is an outworking in spite of reason, an irrational action. It is a paradoxical action of faith. Faith is not faith without doubt. To communicate these actions, which are intrinsically linked to a singular, is tautologically problematic. The communication of belief (through faith and doubt) seeks to bring that which it defines as outside of understanding, into a position of understood. This research is an investigation into the paradox of this action and the precarious liminal state that it inhabits. It is a forming of an anxious state. Using a model derived from Soren Kierkegaard’s writing Fear and Trembling (focusing on the three states of the individal, the universal and the absolute) this research identifies a method of unfolding relationships that seek a position of simultaneity as a propositional position from which to articulate that which is beyond articulation. Within the studio based outcomes of this research an overarching methodology based on the process of production found within analogue photography is applied to material consideration and selection. It is a manifestation of a photographic way of thinking and questioning, based in limitations, but one that is not necessarily tied to the production of photographs. It is argued that materials are what they are as well as what they are not. It is a methodology that reflects the anxiety inherent in the precariousness that this research inhabits. The exegesis explores the conceptual reasoning of the paradoxical construction of belief. Addressed in the three states identified through Kierkegaard, the exegesis expands on the central research question with regards to each state and the bearing that these investigations have on each subsequent state. In the first chapter an approach is made through the idea of the individual. The individual is framed in terms of the self, identified through limit, the limit of self that is known through the action of encountering. The second chapter builds upon this idea of self but repositions it within the relationship of the individual and the universal. The third chapter builds a position around the idea of the absolute.This chapter addresses the issue of simultaneousness discussed in both of the previous chapters and introduces the idea of a simultaneous index formed through the relationship that is enacted in the encounter. This reasoning is paralleled to my own contemporary art practice and argues for a position of simultaneity as a model for articulating questions that may form a propositional state of belief constructed upon faith and doubt.
PERCEPÇÕES DOS PROFESSORES SOBRE A EDUCAÇÃO PELO LAZER PARA PESSOAS COM DEFICIÊNCIA INTELECTUAL

Este artigo é resultadado de uma investigação científica que teve como objetivo analisar as percepções dos professores sobre a educação pautada no lazer para alunos com deficiência intelectual de uma instituição especializada. Optou-se pela pesquisa de campo, de caráter descritivo e abordagem qualitativa, utilizando-se a entrevista semi-estruturada como instrumento de coleta de dados e a análise do conteúdo para análise das falas dos atores sociais. A pesquisa foi realizada com sete professores de uma instituição especializada na cidade de Feira de Santana - Bahia. Ficou constatado que os mesmos não compreendem bem a importância da educação na perspectiva do lazer para os alunos com deficiência, pois não associam que a vivência das atividades de lazer é favorável no processo de ensinoaprendizagem.
DEVICE COMPRISING A CONNECTING COMPONENT AND METHOD FOR PRODUCING A CONNECTING COMPONENT

A device is specified, said device comprising a first component (1),a second component (2), and a connecting component (3) comprising at least a first region (31) and at least a second region (32). The composition of the first region (31) differs from the composition of the second region (32). The connecting component (3) is arranged between the first component (1) and the second component (2). The connecting component (3) comprises different kinds of metals, the first region (31) of the connecting component (3) comprises a first metal (41), and the concentration of the first metal (41) is greater in the first region (31) than the concentration of the first metal (41) in the second region (32).
Contributo al capitale circolante per Telzas Sp. z o.o.

Il progetto riguarda il sostegno dell'imprenditore nel fornire liquidità finanziaria e il sostegno alle attività in corso a causa delle difficoltà finanziarie incontrate dall'imprenditore a causa dell'epidemia di COVID-19. Assistenza finanziaria erogata nell'ambito del programma n. SA.57015 (2020/N)
Sharing cities

Sharing Cities has four key objectives.  
1) To achieve scale in the European smart cities market by proving that properly designed smart city solutions, based around common needs, can be integrated in complex urban environments.  This will be done in a way that exhibits their true potential and allows for the significant scale-up and consequent increase in social, economic and environmental value. 
2) Adopt a digital first approach which proves the extent to which ICT integration can improve and connect up existing infrastructure, as well as the design and running of new city infrastructure.  This will also allow for the creation of a new set of next stage digital services which will help citizens make better and beneficial choices around energy efficiency and mobility, which when scaled up will enhance the city’s ability to hit key targets for mobility, housing, energy efficiency and resilience, and economic development. 
3) Accelerate the market to understand, develop and trial business, investment and governance models, essential for the true aggregation and replication (through collaboration) of smart city solutions in cities of different sizes and maturities. In doing this, we intend to accelerate the pace by which we make transformative improvements, and enhance sustainability in communities. 
4) Share and collaborate for society: to respond to increasing demand for participation; to enhance mechanisms for citizens’ engagement; to improve local governments capacity for policy making and service delivery through collaboration and co-design; resulting in outcomes that are better for citizens, businesses and visitors.  These will be delivered by a range of expert partners across 8 work packages.
dispensador ventilado

dispensador ventilado um dispensador para dispensar diferentes quantidades de concentrado químico em uma corrente de um recipiente de concentrado, em que o recipiente tem uma válvula de alívio de pressão, e o dispensador proporciona uma ventilação de ar, quando é operado. de uma maneira preferida, o dispensador e a tampa são conectados integralmente com a ventilação de alívio de pressão localizada na tampa. o dispensador é capaz de dispensar uma ampla gama de produtos químicos com preocupação mínima com o tipo de produto químico e as pressões geradas no recipiente.
Evaluation of Run-Off Supply Projects in Hamadan Province (Iran)

Water resources project is for the control or use of water. Where utilization is proposed, the first question is usually how much water is needed .This is probably the most difficult of all the design problems to answer accurately because it involves social and economic aspect as well as engineering. In order to meet the various demands and of water requirements in Hamadan province which is situated in west of Iran, more than 28 projects were defined and studied, but only few of them were adopted. This paper presents a criteria based on the ratio of reservoir capacity to volume of earthen dam named as feasibility factor (F) for exact evaluation of different alternatives to assure the designer, so that, to obtain sufficient quantity of water in a form which can be easily and cheaply made fit for various uses.