SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
The Dry Valley Lakes, Antarctica: from sulfur stains on Earth to sulfur stains in the Jovian system

Most organisms dwell in what we consider to be normal environments, while others, which are called extremophiles,
may thrive in harsher conditions. These living organisms are mainly of unicellular (both prokaryotes and, to a lesser
extent, there are some eukaryotes) But the extremophiles also include multicellular organisms, including worms, insects
and crustaceans. In the present work we survey specific extremophiles in some detail. Astrobiology is concerned with all
of these extremophiles, as they may be models for extant life in similar environments elsewhere in the universe. In the
more restricted search for life through exploration of the Solar System, the main focus is on the preparation of suites of
experiments that may attempt to discover the habitability of planets and their satellites. In this context we ask ourselves:
What biosignatures can facilitate life detection, both unicellular and multicellular, in extreme environments? The
environments that are within reach of present and future space missions include the Jupiter satellite Europa. The icecovered
lakes of Antarctica's McMurdo Dry Valleys have long been of interest to astrobiology. These environments
harbor unique microbial ecosystems that could orient us how to plan our experiments on Europa.
Conduction and convection heat transfer characteristics of water–Au nanofluid in a cubic enclosure with differentially heated side walls

Abstract The present work deals with the steady-state natural convection in a cubic enclosure filled with the water–Au nanofluid. The enclosure is heated on the vertical and cooled from the adjacent wall, while the other walls are adiabatic. The governing differential equations have been solved by the standard finite volume method and the hydrodynamic and thermal fields were coupled together using the Boussinesq approximation. The effects of the volume fraction of nanoparticles in the range 0 % ⩽ φ ⩽ 5 % on the heat transfer characteristics of Au nanofluids are investigated for the nominal values of base-fluid Rayleigh number 10 1 ⩽ Ra bf ⩽ 10 6 . It is shown that adding nanoparticles in a base-fluid delays the onset of convection. Contrary to what is argued by many authors, we show by numerical simulations that the mean Nusselt number Nu ‾ values for nanofluids φ > 0 % are smaller than those obtained in the case of pure fluid with the same nominal value of Rayleigh number Ra bf due to the weakening of convective transport.
MODULATING AGENTS FOR ANTIMICROBIAL COATINGS

An exemplary medical device for subcutaneous disposal at least partially within a patient is disclosed, comprising an antimicrobial material comprising at least one metal and an agent that inhibits diffusion of the at least one metal from the antimicrobial material. The antimicrobial material comprises a coating formed over at least a portion of a surface of the medical device. Methods for preparing medical devices and methods of using the medical devices having the antimicrobial material are also disclosed.
Security assurance framework for networked vehicular technology

The assurance of security, privacy, reliability and safety features is key-point to unlock the enormous potential that the connected vehicles systems paradigm i.e., the dynamic Cyberphysical system of highly-equipped infrastructure-connected vehicles with numerous third-party components, can offer towards safer transportation. The emerging systems expose a variety of wireless-communication and hardware interfaces which result in a large attack surface; thus, attempts to assess the degree of confidence that security needs are satisfied come with prohibited cost for automotive stakeholders and OEMs.
SAFERtec project will leverage a highly-skilled consortium to first model the varying exposure of a prototype connected vehicle system to numerous threats appearing under two generic instances of the increasingly pervasive V2I setting. One relates to road-side unit communication while the other involves the interaction with cloud application and passengers' smart devices. Then, adopting a systematic vertical approach SAFERtec will obtain an in-depth look of the possible vulnerabilities performing penetration-testing on individual hardware components and upper-layer V2I applications. Considering the available security mechanisms a third party provider already applies to each module, SAFERtec will determine a corresponding protection profile as a summary of the identified risks. An innovative framework appropriately designed for unified and thus, cost-effective use across all modules will employ statistical tools and security metrics to quantify the involved security assurance levels and also feed the incomplete automotive standards. Research on dependability methods will then allow the framework's transition from individual modules to the connected vehicle system. All above results will be incorporated and made available through an open-access toolkit that will pave the way towards the cost-effective identification of security assurance levels for connected vehicle systems.
Molecular analysis of melanoma-induced sentinel lymph node immune dysfunction

Sentinel lymph nodes (SLNs) of melanoma patients show evidence of tumor-induced immune dysfunction. Our previous works have shown that IL-10 and IFNγ co-regulate indoleamine-2,3-dioxygenase (IDO)-expressing immunosuppressive dendritic cells (DCs) in melanoma SLNs. The goal of this study is to examine the relationship between melanoma SLN tumor burden and the degree of SLN immune dysfunction as a model to study tumor-induced immune dysfunction. We hypothesize that SLN tumor burden correlates with the degree of SLN immune dysfunction.Patients undergoing SLN biopsy for clinical stages I and II melanomas were enrolled in the study under an IRB-approved protocol. During the SLN biopsy, non-hot and non-blue portion of the SLN was harvested, flash-frozen in liquid nitrogen, and mRNA was extracted. By using quantitative real-time PCR, gene expressions of cytokines (IL-4, IL-10, IFNγ, TGFβ, GM-CSF) and the surrogates of immunosuppressive regulatory and effector cells (IDO-expressing DCs and Foxp3-expressing T-regs, respectively) were measured and correlated against the SLN tumor burden (MART1) and against each other. The data were log transformed for normalization. Statistical test used Student's t-test and stepwise multivariate regression analysis. Statistical significance was determined at P < 0.05.SLNs of 74 patients were analyzed in this analysis. Ten of seventy-four patients (13.5%) had tumor-positive SLNs. MART1 gene expression showed a significant difference between the SLN (+) and SLN (-) groups (P = 0.04). Among the various cytokines, multivariate analysis showed that only IFNγ gene expression correlated independently with MART1 gene expression (P < 0.0001, r = 0.91). Similar multivariate analyses show that IFNγ (P < 0.0001, r = 0.78), IL-10 (P = 0.0037, r = 0.60), and TGFβ (P < 0.0001, r = 0.95) gene expressions correlated independently with IDO gene expression. IFNγ (P < 0.0001, r = 0.87) and GM-CSF (P = 0.042, r = 0.76) gene expressions correlated independently with Foxp3 gene expression. MART1 gene expression showed independent correlation with IDO (P = 0.0002, r = 0.75) and Foxp3 (P = 0.0002, r = 0.75) gene expressions.SLN tumor burden correlates with immunosuppressive IDO and Foxp3 expressions within the SLNs of melanoma patients. Our data are consistent with our theory that melanoma induces expressions of specific cytokines, which in turn, stimulate immune suppressors within the SLN. This study also supports our previous finding that IL-10 and IFNγ co-regulate IDO within the SLN. In our data, IFNγ is the sole cytokine that correlates with the SLN tumor burden and seems to play a central role in tumor-induced immunological changes in the SLN immune microenvironment.
Protection by an antioxidant of rotenone-induced neuromotor decline, reactive oxygen species generation and cellular stress in mouse brain

Exposure to environmental toxins, including rotenone, results in central nervous system and systemic toxicity. Rotenone is a widely used pesticide and a mitochondrial complex I (CI) inhibitor. This study reports effectiveness of a synthetic lipoylcarnitine antioxidant compound, lipoylcarnitine methyl ester iodide (PMX-500F), for treatment of chronic rotenone induced neurological deficits in mice. Mice (C57BL/6NTac; two months of age) received oral administration of rotenone (30 mg/kg/day) or vehicle, preceded by intraperitoneal injection of PMX-500F (19 mg/kg) or vehicle for four weeks. In the Rota-rod test, rotenone treatment had no effect (P>0.05); however, PMX-500F treatment improved locomotor coordination and endurance (latency to fall time; P<0.05). For neuromuscular strength (wire hang test), rotenone treated mice showed reduced latency to fall compared to control mice (P<0.05). PMX-500F treatment improved the outcome in both control and rotenone exposed mice (P<0.05). Rotenone administration increased ROS generation in the forebrain and midbrain regions, but not in the cerebellum (P<0.05). Co-treatment with PMX-500F normalized the ROS in forebrain and midbrain regions to that of the control concentrations. In rotenone administered mice, activated stress-activated protein kinase/c-Jun NH2-terminal kinase (pSAPK/JNK) was higher in forebrain and midbrain lysates than in control mice (P<0.05) and treatment with PMX-500F reduced pSAPK/JNK to control levels. The pSAPK/JNK levels in the cerebellum were similar in all four groups (P>0.05). Total SAPK/JNK was not altered by either rotenone or PMX-500F treatment (P>0.05). These results illustrate that an antioxidant, here PMX-500F, provides protection against rotenone induced decline in neuromotor function, reactive oxygen species (ROS) generation and cellular stress.
A commercial platform providing operational air quality services using eo data

The ambition of BlueSky project is to build a self-sustainable service platform providing Air Quality services based on Earth Observation data. These services will provide updated emissions inventories, advanced forecasting systems and decision making tools to manage air quality events in order reduce their economic and societal impact. This platform will cover pollutants having a higher economic and social impact such as PM2.5, PM10, SO2, NO2 and CO.

BlueSky team wants to demonstrate the viability and sustainability of BlueSky platform through developing business cases in new identified markets such as Mobile Apps, Smart Home Devices, Green Supply Chain Industries, Insurance Risk, Smart Cities and Real Estate as well as established markets such as Environmental Regulation and Planning. We want also to develop our platform services in markets where the impact will be higher and where the sustainability of the project will be easier. These markets will be Europe, China and India. We already engaged real key potential customers from these markets.

BlueSky project would also like to build a one-stop portal platform containing tools and functionalities that facilitate and simplify the access, visualization and management of the large volume data generated. We think that improving data handling combined with an innovative and attractive communication strategy is a must to bridge some existing gaps between existing potential customers and our team.
The mills and fairies' route

The project, implemented by the Town of Cercivento, aims at promoting and enhancing thematic itineraries inspired to the fairytales of the local tradition and the mills, that have always characterised the area and were the main source of hydraulic energy in the area. Maintenance and renovation work will be carried out on the routes, the rest areas and the safety railings; suitable outdoor furniture will be provided as well as educational boards and signage. Part of a timber chute (slide) and of a traditional timber-carrying telpher will be reconstructed. In this sense this project aims at encouraging a sort of thematic tourism, enhancing resources and typical local products such as honey, apples and berries. The tourist offer in the area is then integrated with sports activities - both in summer and in winter - while promoting “lesser” tourist destinations and granting greater visibility to the territory.
Genetically enhanced, optically superior tissues (ghosts)

Most biological tissues are optically opaque, largely precluding access by light microscopy. In stark contrast, some living tissues and organisms are highly transparent. Examples include many deep-sea fish, your retina, and cells that we exposed to directed evolution.
Here we propose to uncover the genetic basis of tissue transparency, such that living cells and tissue cultures can be optically cleared by precision genetics. For this we will combine insights into origins of retina transparency, and a set of unique methods, to answer the question how genetically cells become more transparent during directed evolution.
Specifically, we will use a three-fold approach to find transparency genes that do not compromise cellular integrity. For this we will use i) directed evolution towards transparency while co-selecting for cell fitness, ii) extensive phenotyping of transparent cells, both optically and functionally, and iii) use of transcriptomics to rule out stressed cells, and those that deviate too much from wildtype gene expression profiles.
Knowing about physiological transparency genes will allow unprecedented insights into living tissues. If model tissues in the lab were just 1% as transparent as some glass-like fish found in the deep sea, optical microscopes could unleash their full potential, and enable high resolution views into developmental processes in their native environment. We see further transformative potential especially in the fields of organotypic tissue models, functional brain imaging, as well as pharmaceutical screens in 3D tissue cultures.
Zeolite synthesis in unusual reactors for enhanced catalysts

Approximately 9 out of 10 chemical processes use a solid catalyst, as they increase the efficiency of chemical reactions while being recyclable. Zeolites are one of the most iconic types. These porous crystalline oxides are built from networks of aluminum and silicon nodes and are characterized by regular pores with dimensions similar to most of the molecules that sustain modern society.

Although zeolite synthesis is essentially an assembly of silica and alumina around positively charged template molecules, the outcome heavily depends on kinetics. Yet, classic reactors and strategies barely allow any fine-control over the kinetic interplay, and thus the zeolite made, due the complex and not well understood role of Coulomb and other interactions among the assembling species, and their concentration profiles. Even for established catalysts, synthetic control over their key properties is often lacking. However, such fine-control is essential to develop better catalytic processes in the light of global challenges.

Z-EURECA wants to revolutionize zeolite synthesis, not by the usual search for ingredients, but by introducing new reactor-based handles, specifically external electric fields and fed-batch modes, to exert control over kinetic pathways. Based on new reactor designs, active manipulation of the various Coulomb and interspecies interactions and local concentration gradients during synthesis will be possible.

This bottom-up revolution will i) provide missing insights into the fundamentals of relevant zeolite synthesis, ii) develop active tools that engineer access to synthetic fine-control over zeolites and iii) validate this fine-control in relevant catalytic reactions for superior acid and redox zeolites in prominent sustainable catalysis challenges of our resource-hungry society.
Error Events Due to Island Size Variations in Bit Patterned Media

Control of the variations of island properties is one of the key challenges in fabricating Bit-Patterned Media for future storage systems. The presence on any variation in the size and position of an island has a detrimental effect on the ability to recover recorded data, particularly in the case of variation in island size. By analyzing error events when island size variations are present we have identified that these are more likely to be single-bit in nature. To understand the origins of these error events we have investigated the size and magnetization state of islands in the vicinity where a single-bit error event is encountered. It is shown that these error events occur due to particular combinations of island size and magnetization state for the three islands investigated. In every case the central island, from which the data bit is recovered in error, is small compared to the nominal island size. These results show that size variations must be controlled in the fabrication process in order to maximize the bit-error-rate performance of the read channel.
Garenoxacin in Skin & Skin Structure Infections Sustained Due to Road Traffic Accident

Skin and soft tissue infections represent a continuum of symptoms that range from uncomplicated cellulitis to the potentially lethal entity necrotizing fasciitis that is often considered to be microbial invasions of the epidermis, dermis and subcutaneous tissues. Garenoxacin, a newer oral des-fluoroquinolone having potent antimicrobial activity against wide variety of common pathogens involved in skin and skin structure infections (SSTIs), including the resistant strains offer the advantage of broad spectrum of coverage including gram positive, gram negative and anaerobic organisms. This case study indicates the utility of garenoxacin in treating skin and soft tissue infections caused by road traffic accidents.
Fire Control Emergency Rescue Resources Allocation Based on Calamities and Accidents Risk Evaluation

In order to solve the unreasonable fire control emergency rescue resources allocation based on local government's administrative level and improve the efficiency of the use of fire control emergency rescue resources, 9175 alarm receiving and summoning of Yunnan Fire Force of China in 2012 is analyzed by national fire statistics and management system. It shows that fire control emergency rescue resources allocation Shortage based on local government's administrative level coexist with waste of it, these fire control emergency rescue resources cannot meet with local actual requirements, not equal to the local potential risk, and Affects calamities and accidents rescue efficiency. According to the local Calamities and Accidents risk evaluation, actual occurrence of local calamities and accidents, and local fire force's ability to cope with calamities and accidents in recent five years, comprehensive fire emergency rescue resources allocation can improve the utilization efficiency of fire control emergency rescue resources.
Effect for Children with Children′s Cerebral Palsy Head Controlling with Head Acupoints Cluster Needling Combined with Pillow Little Muscle Group Training

Objective:To evaluate the effect of head acupoints cluster needling combined with pillow little muscle group training on head control of children with cerebral plasy.Methods:60 children were divided into 2 groups stochastically:head acupoints cluster needling,head acupoints cluster needling combined with pillow little muscle group training.All children were appraised for GMFM and pediatric cerebral palsy indexing and curative effect evaluation self test table.The effects before and after treatment of each group were evaluated.Results:The discrepancies had statiscal meaning(P0.05).After 12 weeks treating,the GMFM of two groups had statiscal meaning(P0.05).The grade of pediatric cerebral palsy indexing and curative effect evaluation self test table of combination group was higher than the head acupoints cluster needling group(P0.05).Conclusion:Head acupoints cluster needling combined with pillow little muscle group training can promote the functions of raising and controlling head of children with cerebral palsy.
TEXMEDIN

In today’s knowledge economy, technological know-how is a powerful drive for economic growth. Mediterranean industrial economies need transition to the knowledge economy in order to improve their competitiveness. At the same time, creativity and design are key strategic assets to increase attractiveness of commercial goods. Competitiveness can no more be confined to sheer reduction of costs but should be enhanced by the application of new technologies and research in order to generate greater added value even in traditional economic sectors. Textiles and Apparel (T&A) is a major sector of the Mediterranean economy. On the other hand, many areas with long-standing vocation to T&A production suffer from decline due to fierce global competition and lack of investments in innovation in this sector. The TEXMEDIN project aims to rethink T&A development strategies by creating a transnational cluster to valorise the existing technical know-how and T&A creative heritage of these areas. It aims to formulate new approaches and methodologies to support higher levels of technological and non- technological innovation as well as improved design patterns in the T&A clusters and value chain. It will design new measures to train emerging T&A designers and entrepreneurs by valorising the sectoral know-how and creative background in collaboration with existing service centers and business supporting organisations.
Evaluation of sustainable management techniques for preventing iron chlorosis in the grapevine

Background and Aims The control of iron (Fe) chlorosis by synthetic Fe chelates is costly and their application can have adverse environmental impacts. We investigated the effectiveness of alternative vineyard strategies to prevent Fe chlorosis in grapevines. Methods and Results An experiment was conducted over two consecutive seasons on Vitis vinifera L. cv. Cabernet Sauvignon grafted on the Fe-chlorosis susceptible Vitis riparia grown in pots filled with calcareous soil. Intercropping with Festuca rubra enhanced leaf chlorophyll index and reduced the root activity of phosphoenolpyruvate carboxylase enzyme, a physiological marker of Fe deficiency. This response was similar to that of supplying Fe-ethylenediamine-N,N'-bis(2-hydroxyphenyl)acetic acid to soil. Application of ammonium with 3,4-dimethylpyrazole phosphate (a nitrification inhibitor) increased leaf chlorophyll index and stomatal length, and induced root biochemical responses similar to those with Fe-ethylenediamine-N,N'-bis(2-hydroxyphenylaceticacid) application. Leaf-applied Fe-ethylenediaminetetraacetic acid induced a high root citric acid concentration, suggesting a limited translocation of Fe from leaves to roots. Intercropping with Festuca rubra decreased the leaf fluorescence-derived parameters in the first year and increased the leaf stomata conductance in the second year of the experiment. Conclusions The results demonstrate the potential for preventing grapevine Fe chlorosis more sustainably through managing ammonium nutrition and adopting intercropping with Fe-efficient grasses. Significance of the Study The data provide evidence of the effectiveness and physiological responses of agronomic strategies, alternative to synthetic Fe chelates, for preventing Fe deficiency in the grapevine.