SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Computational Analysis of Promoter Elements and Chromatin Features in Yeast

Regulatory elements in promoter sequences typically function as binding sites for transcription factor proteins and thus are critical determinants of gene transcription. There is growing evidence that chromatin features, such as histone modifications or nucleosome positions, also have important roles in transcriptional regulation. Recent functional genomics and computational studies have yielded extensive datasets cataloging transcription factor binding sites (TFBS) and chromatin features, such as nucleosome positions, throughout the yeast genome. However, much of this data can be difficult to navigate or analyze efficiently. This chapter describes practical methods for the visualization, data mining, and statistical analysis of yeast promoter elements and chromatin features using two Web-accessible bioinformatics databases: ChromatinDB and Ceres.
Selective agonists for serotonin receptors

SAFER will train 5 ESRs, PhD students, to obtain ample scientific, business and transferrable skills, arming them with the expertise to translate knowledge into products and services with importance for European industry and society. All ESRs will first train together at one university to develop complementary skills and basic research data; and subsequently move to two SMEs for applied and commercial research. 

The ultimate scientific goal for the SAFER program is to gain molecular understanding and improve selectivity in treatments 
of CNS-related disorders. This will be done through an interdisciplinary and intersectoral approach, building on a strong complementarity between partners, with a particular focus on the serotonin 5-HT2A receptor – the primary target for many pharmaceuticals and hallucinogens. SAFER will generate and cross-interpret pharmacology and crystallographic data, and construct computational mechanistic models and databases that can explain and guide its experiments. Thus, SAFER will gain new insights into molecular mechanisms that are fundamental to understand the biological and therapeutic effects, and to develop safer drugs. 
SAFER ESRs will be highly competitive on the job market and much in demand. In particular, crystallography and biased signalling pharmacology of G protein-coupled receptors (e.g. 5-HT2A) are new and highly active research fields, today mastered by only a very few research groups worldwide. The timing and location of SAFER are particularly opportune, taking advantage of the new synchrotron MAX IV in Lund, Sweden, which is world leading for the study of challenging crystals. SAFER will seek to exploit innovation opportunities from novel molecular mechanisms, ligands, and crystal structures. The results will be integrated into a public community resource, GPCRdb, giving a unique potential to achieve community impact and long-term sustainability.
Favorable Vessel Healing After Nobori Biolimus A9-Eluting Stent Implantation

Nobori is a novel biolimus A9-eluting stent (BES) coated with a biodegradable polymer only on the abluminal side, which degrades over 6-9 months post-stent deployment. The course of vessel reaction after deployment at these time points remains unclear.We serially evaluated 28 BES implanted in de novo coronary lesions of 23 patients using optical coherence tomography (OCT) at 6 and 12 months post-stenting. Standard OCT variables, the percentage of stent with peri-strut low-intensity area (PLIA, a region around stent struts homogenously showing lesser intensity than the surrounding tissue, suggesting fibrin deposition or impaired neointima maturation) and that with in-stent thrombi were evaluated. There was a significant, but small increase in neointimal thickness (72 ± 23 to 82 ± 25 µm, P=0.006) from the 6- to the 12-month follow-up, without a significant decrease in minimum lumen area (P=0.30). The incidences of uncovered and malapposed struts were low at 6 months and reduced further at 12 months (3.96 ± 3.97% to 1.51 ± 1.63%, P=0.001, and 0.50 ± 1.84% to 0.06 ± 0.24%, P=0.20, respectively). The frequency of stent with PLIA decreased during the follow-up (57% to 32%, P=0.05) and that with in-stent thrombi also numerically decreased (7% to 0%, P=0.24).Neointimal hyperplasia was persistently suppressed following BES implantation up to 12 months. Simultaneously, favorable vessel healing was achieved at 6 months without a delaying adverse reaction for up to 12 months.
A revised life table and survivorship curve for Albertosaurus sarcophagus based on the Dry Island mass death assemblageThis article is one of a series of papers published in this Special Issue on the theme Albertosaurus.

In 1910 a crew from the American Museum of Natural History discovered a bone bed composed primarily of the large tyrannosaurid Albertosaurus sarcophagus in what is now Dry Island Buffalo Jump Provincial Park in Alberta, Canada. Study of the remains from the site allowed the first life table and survivorship curve for a non-avian dinosaur to be created. These have served as a model for subsequent studies of dinosaurian population biology. Since 2006, the discovery and preparation of hundreds of new elements from the bone bed stand to substantially increase the minimum number of individuals (MNI) represented. This would allow testing of previous conclusions regarding the population biology of these animals and refinement of our understanding of the patterns of survivorship. Here, four formerly unrecognized individuals from the Dry Island assemblage are revealed and a revised life table presented. As in the previous analysis, a left skewed age distribution and sigmoidal survivorship pattern were found. Annual mortality rates averaged 3.47% between ages two and 13 and then increased to a mean of 19.5% prior to extinction of the cohort after 28 years of age. Mean life expectancy for individuals surviving to two years of age was 15.19 years. Mid-life increase in attrition corresponds to entrance into the breeding population. The MNI is unlikely to substantially increase, and new individuals are unlikely to affect the pattern of survivorship inferred here. Nevertheless, future excavations stand to reveal more about the anatomical and pathological variance within the Dry Island Albertosaurus population.
Design and analysis of a wide bandwidth immersion MEMS transducer array for fault detection in power cables

In this paper a 1-D micromachined-based transducer array is proposed for fault detection in high power transmission power cables. The proposed array benefits from silicon microfabrication techniques, and includes N = 101 capacitive micromachined cells that are located 5μm from each other. Transducer cells are actuated simultaneously, creating an acoustic wave that travels in the surrounding water domain. COMSOL acoustic simulations indicate that this array has a bandwidth of 7 MHz at -6 dB, resulting in a fractional bandwidth of BW/f <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">0</sub> = 70%. This array generates a directive beam pattern with a beam width of 3° at the central frequency of f = 10 MHz, resulting in high-resolution fault detection.
A Brownian model for recurrent volcanic eruptions: an application to Miyakejima volcano (Japan)

The definition of probabilistic models as mathematical structures to describe the response of a volcanic system is a plausible approach to characterize the temporal behavior of volcanic eruptions and constitutes a tool for long-term eruption forecasting. This kind of approach is motivated by the fact that volcanoes are complex systems in which a completely deterministic description of the processes preceding eruptions is practically impossible. To describe recurrent eruptive activity, we apply a physically motivated probabilistic model based on the characteristics of the Brownian passage-time (BPT) distribution; the physical process defining this model can be described by the steady rise of a state variable from a ground state to a failure threshold; adding Brownian perturbations to the steady loading produces a stochastic load-state process (a Brownian relaxation oscillator) in which an eruption relaxes the load state to begin a new eruptive cycle. The Brownian relaxation oscillator and Brownian passage-time distribution connect together physical notions of unobservable loading and failure processes of a point process with observable response statistics. The Brownian passage-time model is parameterized by the mean rate of event occurrence, μ, and the aperiodicity about the mean, α. We apply this model to analyze the eruptive history of Miyakejima volcano, Japan, finding a value of 44.2 (±6.5 years) for the μ parameter and 0.51 (±0.01) for the (dimensionless) α parameter. The comparison with other models often used in volcanological literature shows that this physically motivated model may be a good descriptor of volcanic systems that produce eruptions with a characteristic size. BPT is clearly superior to the Exponential distribution, and the fit to the data is comparable to other two-parameters models. Nonetheless, being a physically motivated model, it provides an insight into the macro-mechanical processes driving the system.
Thermophysical Properties of Alumina-Ethanol-Water Based Nanofluids

Addition of nanosized particles as an additive to the fluid in order to improve the properties of fluid has gained much attention in recent era. Limited studies are reported in literature for the preparation and estimation of thermophysical properties of nanofluids based on binary mixture of liquids. Thermophysical properties of nanofluids including effective density and effective viscosity of alumina nanoparticles based nanofluids are measured at a temperature range of 20-60°C. The study is carried out in binary mixture of ethanol and water at different concentrations. Alumina nanoparticles of 50 nm are used at different particle loading i.e. 0-0.3 wt% in different proportions of ethanol and water. The analysis of measured experimental values indicates that the addition of nanoparticles in different concentrations has significant effect on the effective density and the effective viscosity of fluids. The predicted values are estimated from correlation coefficients as a function of temperature.
Close up: your id is your face

In the age of artificial intelligence, identifying anyone in public space through facial recognition is becoming faster and easier. However, the technologies are not without flaws. Recent studies have shown that the technologies are prone to gender and skin-colour biases, and not highly accurate. Despite their imperfections, governments around the world deploy the technologies at a breakneck pace. Strong criticisms have been heard over the lack of appropriate legal frameworks to regulate technologies that can negatively impact civil liberties and personal freedoms. Since a few years, concerns have further grown concerning their use in China where they are deployed to support a social credit system to rate citizens’ behaviour. Facial recognition technologies can potentially be very pervasive surveillance tools. The proposed research will identify the threats and risks that the use of facial recognition for surveillance purposes poses to the rights to privacy and data protection as defined at EU level. The objective is to define the legitimate and proportionate uses of the technologies based on country trends (France, UK, USA, and China), their technical characteristics, and the legal frameworks applicable to the rights to privacy and data protection.
Mental Health Status of Ontario Injured Workers With Permanent Impairments

Each year, approximately 31,000 Canadian injured worker claimants are certified to have permanent impairments associated with the initial workplace incident. Permanent impairments are characterized by ongoing pain, and limitations in physical function and activity participation--all predisposing factors to mental health problems. Here we examine the post-accident mental health status of a sample of Ontario injured workers with permanent impairments.We analyze data from a cross-sectional telephone survey of 494 injured workers. Mental health status is examined using nine dichotomous diagnostic, symptomatic and functional mental health indicators identified by survey respondents as non-present, or having pre- or post-injury onset, and the CES-D. We describe the relationship of these indicators and work injury, demographic and socio-economic factors.Post-injury onset mental health problems are elevated compared to pre-injury onset in seven of nine indicators. Diagnosed depression, medication abuse, inability to concentrate, and sleep problems are elevated compared to general Canadian population prevalence. Diagnosed depression is elevated compared to populations with pain and chronic health conditions. Higher education and pre-injury income are associated with lower depressive symptoms. Men and older individuals are less likely to report a diagnosis of depression. Older individuals are less likely to report concentration problems.These data paint a troubling mental health picture among injured workers with permanent impairments. Implications for return-to-work and income recovery, health service access and rehabilitation within and outside the compensation system are discussed.
Cave del Predil international geomineral park 

This project will set up an international, geomineral, historical and environmental route inside the dismantled Raibl mine (at Cave del Predil in the Municipality of Tarvisio) which is unique in the Friuli Venezia Giulia region. Specifically, a route is created inside the mine systems and the Kaiser Franz Erbstollen tunnel (Francesco tunnel) will be renovated as well as the Camerone Santa Barbara facility that will be adapted to house an exhibition space. The project also entails an upgrading of the rail transport system, the acquisition of a small passenger train similar to the one used by the miners, and the installation of an adequate primary and emergency lighting system. The project aims therefore at the recovery and the tourist enhancement of the Raibl mine, in order to complete, consolidate and improve the current offer of tourist services in the area, where the Cave del Predil Mineralogical Museum is located. It is envisaged to set up similar connections and collaborations with relevant Museums present in Slovenia (Idrija and Mezica) and in Carinthia (Beliberg), in order to extend and intensity cross-border cooperation in the cultural and tourist fields through the creation of a network connecting local authorities and associations active in the interested areas.
Desenvolvimento de um carrinho de transporte autônomo e modular para a realização de operações logísticas em ambientes fechados e em espaço aberto com sistema de vídeo, laser e radionavegação

Number_reference_aid_programa: SA.41471(2015/X) Objetivo do auxílio público: Artigo 25.º do Regulamento (CE) n.º 651/2014, de 17 de junho de 2014, que declara certas categorias de auxílios compatíveis com o mercado interno, em aplicação dos artigos 107.º e 108.º do Tratado É isso mesmo. EU L 187/1 de 26.6.2014). Como parte do projeto, a Eko-Laser planeja desenvolver um carrinho de transporte modular e autônomo para realizar operações logísticas em ambientes fechados e em um espaço aberto com um sistema de navegação por vídeo, laser e rádio. O Eko-Laser AGV T1500 será capaz de realizar operações de transporte de forma eficaz em uma variedade de condições ambientais. Ao contrário da maioria dos AGVs padrão, que são preparados apenas para operação em ambientes internos (salões de produção, armazéns, etc.), o AGV T1500 também será capaz de deixar edifícios e realizar tarefas de transporte em ambientes externos, incluindo condições climáticas desfavoráveis, como geada, neve, nevoeiro ou chuva leve. Foi dada especial atenção ao trabalho de I & D no sistema de posicionamento do veículo, que é trabalhar com precisão tanto dentro como fora de edifícios. Os algoritmos de controlo de veículos serão muito avançados, não só a rota será otimizada com base em mapas de terreno e estratégias eficazes de prevenção de obstáculos, mas também métodos baseados na aprendizagem e na seleção da rota correta com base nas estatísticas das viagens anteriores. Foi dada especial atenção à segurança — tanto os arredores, os carrinhos e as mercadorias transportadas. Para o efeito, prevê-se desenvolver uma solução globalmente inovadora para identificar o tipo de mercadorias transportadas e adaptar o algoritmo de controlo do carrinho a mercadorias particularmente difíceis de transportar (por exemplo, contentores líquidos).
Textile reflections: multi-sensory representation of textile work in latin poetry and prose

This interdisciplinary research project explores and re-interprets the representations of textile work and textiles in Latin literature. Literary analysis taking into account matters of metrics, sound figures and structure will show that Latin authors display greater technical understanding of textile work than previously assumed, and suggest that their tacit knowledge of textiles/textile production has influenced the artistic development of descriptions of textile crafts. By indexing and analysing all references to textile work in Latin sources (as called for by J.P. Wild in 2000), I will address the discipline-wide problem of multi-purpose terminology. Interdisciplinarity is fundamental to my project and a core value of my host institution (Centre for Textile Research): observation and recordings of reconstruction of ancient textile work (experimental archaeology) will be the basis for my investigation of semblances of textile work in metre, sound-play and structure in Latin texts, providing thematic literary interpretation, highlighting neglected connections between structure, sound-play and meaning. The project results will complement knowledge based on epigraphy and archaeology of the role played by textiles and textile production in Roman life, their ideological connotations, and trials investigation of ancient soundscapes through literary sources. My project relates to four disciplines: philology, sound studies, ancient history, and archaeology. An ambitious training programme is planned for me to expand my expertise in Classical Philology to include aspects of textile archaeology and ancient history, an outcome of this will be a distance learning course, also involving me providing training in online learning at CTR. To maximise long-term impact, I will receive training in research management and network building, e.g. through planned conference organisation and co-publication of a paper with my supervisor Prof. Nosch, part of a wider dissemination strategy.
The effect of potential large-scale bioreactor environmental heterogeneities during fed-batch culture on the performance of an industrially-relevant GS-CHO cell culture, producing an IgG antibody

This study aimed to study the effect of potential large-scale bioreactor environmental heterogeneities during fed-batch culture on the performance of an industrially-relevant GS-CHO cell culture, producing an IgG antibody. Heterogeneity was created by a two-compartment scale-down model, using a well-mixed stirred tank reactor (STR) and plug flow reactor (PFR). A peristaltic pump was used to continuously circulate cell culture from the STR through the PFR. Standard culture parameters were measured and flow cytometry was used to indicate cell viability and mode of cell death.
The results essentially fell into two categories: those without circulation and those with it. In all cases with recirculation, whether nutrients and alkali were added into the STR or the PFR, significantly decreased culture duration (\(\sim\)48 hours shorter) and antibody titre (\(\sim\)20% decrease) were found compared to those experiments without circulation.
It was impossible to conclude anything concerning the impact of bioreactor heterogeneities. Nevertheless, damage associated with peristaltic pumping has relevance to the many aspects of cell culture processes that require transfer of cells in suspension. The 'squeezing' motion of peristaltic pumps may impose sufficient mechanical stress to have decreased cell culture performance. The high biocompatibility of the materials used suggests long-term incompatibility is less likely.
A NICKEL BATTERY ELECTRODE HAVING MULTIPLE COMPOSITION NICKEL HYDROXIDE ACTIVE MATERIALS

A high capacity, long cycle life positive electrode which includes an electronically conductive substrate for conducting electricity through the electrode and an electrochemically active nickel hydroxide material in electrical contact with the electronically conductive substrate, the electrochemically active nickel hydroxide material is composed of at least two different solid solution nickel hydroxide materials each having differing compositions. The positioning of at least two different solid solution nickel hydroxide materials and their relative compositions alter the local redox potential or porosity to force discharge of the electrode in a stepwise fashion from the nickel hydroxide material remote from said conductive network or substrate, through any intermediate nickel hydroxide materials, to the nickel hydroxide material adjacent the conductive network or substrate.
PROCESS FOR THE MANUFACTURE OF A MESOPOROUS PRODUCT

Process for the manufacture of a mesoporous product comprising the following successive steps: a) preparation of a slip comprising: -a solvent, -an additive, -more than 4%, as percentage by volume based on the slip, of a powder formed of ceramic particles, b) oriented freezing of the slip, so as to form a block comprising ice crystals separated by walls, c) removal of the ice crystals from said frozen slip block, optionally removed from the mold, so as to obtain a porous preform, d) removal of the additive, so as to obtain a preformed mesoporous product, the additive and the amount of additive being chosen so that the additive is present in a mesopore-forming micellar phase in said walls, more than 25% by volume of said ceramic particles exhibiting a size less than twice the size of the micelles of said mesopore-forming micellar phase.
Dialog for Innovation And LOcal Growth

The present condition to strengthen the effectiveness and sustainability of innovation policies funded by the ERDF operative programme is creating a real social consensus around these policies. Policies have to be enhanced through more widespread bottom-up participation. Among the main actors of European Structural Funds policies for innovative local development (public administrations, knowledge-production centers, businesses and citizens) particularly limited has been up to now the engagement of citizens. On the contrary, as final receivers, they should have a relevant place (voice) in order to assure the social acceptation of the investment. In most experiences, they objectively remained at the edge of decision and implementation processes. Conversely, innovation policies based on new technological vision and intended to produce added value, need to reach a social and economic commonly shared and supported acceptance by all the stakeholders, citizens included. Moreover, being social welfare (and not only the success of investment projects) the public administrations' mission, an increased involvement and dialogue with social partners is desirable as a tool for improving local social capital. DIALOG project has a main aim which is to improve the effectiveness of innovative policies for regional competitiveness through the creation of a networking, negotiation and exchange model that can involve all the local stakeholders, not only in the design but also in all the stages of local policy implementations. Through identification, modelling and circulation among DIALOG partners of best practices in the field of social innovation focused on increasing the participation of all the stakeholders, the project will define action plans aimed at strengthening the role, skills and participation capacity of the social partners and citizens in the definition and implementation of the innovation ERDF investments.