SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Modeling & Simulation for Intelligent Transportation Systems

In the era of Intelligent Transportation Systems (ITS), the technologies supporting Communications, Sensing & Surveillance mechanisms, and Information & Control systems are spread through the road infrastructure, the vehicles and the users. Their critical mission is the endorsement of efficient, safety and environmental-friendly transport networks that promote the citizens' quality of life. This complex and multidisciplinary challenge requires a conceptual framework to guide the operations and to integrate systems, processes, tools, personnel, and data. In addition, a modular platform with proper modeling, simulating, and visualization capabilities is critical to understand the system-in-analysis, to support well-informed decisions, and to involve the general public in the traffic & environment issue. This work describes the main features of contemporary ITS, emphasizing the Portuguese case, and describes the fundamental modeling & simulation tools that are considered critical to support the daily operation of the urban transportation system.
OCEAN BOTTOM SYSTEM

A seismic data collection system is disclosed. The system may include at least a first housing and a second housing. The first housing may be configured to detachably couple to the second housing. The system mays also include various components such as one or more seismic sensors, a clock, or memory. Each of the components may be arranged in one of the first housing or second housing.
Intelligent debt recovery platform.

Cortx is an intelligent debt recovery platform that automatically processes and analyses insolvency documents to administer and predict the outcome of debt recovery. Through machine learning Cortx increases efficiency, reduces default levels and improves net margins for all stakeholders in the European insolvency sector.
Cortx is designed to be used by insolvency practitioners, credit management firms, and creditors, including financial institutions, local governments, and utility companies. Cortx will generate revenue through a per-case fee model, with a fixed fee charged upfront for every new case onboarded. A recurring per-case per monthly fee is also charged for the ongoing use of analytics and forecasting algorithms on all live cases in a firm’s portfolio. Commercialisation in the UK personal insolvency market will be targeted first, followed by European and North American personal insolvency markets.
Our vision is to reduce the level of non-performing debt on a global scale by bringing machine intelligence to the insolvency market. We aim to be the central data manager for the insolvency market allowing real time transfer of information and documentation with a fully auditable and compliant core. The proposed project will enable us to expand into EU markets, by undertaking in-depth market research, devising a market entry strategy for EU countries, and consolidating strategic partnerships necessary for European commercialisation. It will also allow us to further develop Cortx from its current stage by optimising technical aspects and developing its predictive functions, localising it for EU markets and running a pilot with potential customers in these new markets. At the end of the project we will be ready to commercialise Cortx in our go-to-markets of the UK, Germany, France, Italy and Spain.
Multidimensional governance of climate change adaptation in policy making and practice

The Alpine Space is severely affected by climate change. Adaptation to already unavoidable climatic changes is needed to prevent unmanageable impacts and to safeguard climate-resilient and balanced territorial development. National climate adaptation strategies are in place in some Alpine countries, but implementation is inhibited by multiple obstacles in steering adaptation policies across sectors, levels & actors. Regional adaptation plans are just emerging, adaptation has hardly entered local agendas, and policy mainstreaming is limited on all levels. Governance has a key role in the transition from adaptation strategies to implementation in practice, but capacities for multilevel & cross-sector governance of adaptation processes are lacking in all countries. Adequate governance designs, models & formats, incl. effective cooperation pathways & coordination arrangements, are mostly still missing or not operational. _x000D_
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The project thus tackles joint key challenges of adaptation governance: vertical implementation across territorial levels; horizontal mainstreaming into sector policies; and more active involvement of local, regional & non-governmental actors. Transnational collaboration is essential to learn from shared strengths & weaknesses and from the diversity of governance approaches taken in different countries. The project builds on an existing network of the national authorities responsible for climate adaptation policy-making in 7 Alpine countries, ensuring direct application of outcomes. _x000D_
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The following main outputs will enable public & non-governmental actors to increase their adaptation governance capacities and to improve, effectuate and re-define their approaches: portfolio of multilevel governance approaches, good practices & innovations; pathways & options for mainstreaming adaptation; transferable stakeholder interaction formats; strengthened transnational cooperation networks & closer alignment of national & macro-regional adaptation efforts (EUSALP).
Genetic determinants promoting resistance to bcr-loss in b-cell lymphomas

Loss of B-Cell Receptor (BCR) in lymphoma B cells leads to attenuated PI3K/AKT signaling and altered Myc-dependent transcriptional output, resulting in a competitive disadvantage in BCR-deficient lymphoma cells. The acquisition of genetic events restoring signaling competence is sufficient to improve cellular fitness in BCR-deficient lymphomas. A fraction of Non-Hodgkin-B-cell lymphomas carry missense mutations in FOXO1, a transcription factor essential during B cell development, and a main target of the PI3K/AKT pathway, which relays survival signals downstream of the BCR. In preliminary studies, we found that cells with FOXO1 mutations rewire their signaling status showing a) activation of stress-activated protein kinases (SAPKs) and PI3K/AKT, b) altered responses to key upstream receptors, such as CD40 and BCR, and c) improved fitness. In this context, I propose to investigate whether FOXO1 mutations are able to provide resistance to BCR-loss in transformed B cells, by favoring the activation of PI3K/AKT, SAPK/JNK (and potentially other) signaling pathways. This hypothesis will be tested using mouse and human models that allow conditional deletion of the BCR in FOXO1 mutant B cells, determining whether expression of FOXO1 mutations is: a) sufficient to release normal B cells from BCR-dependency, and b) able to restore competitive fitness to BCR-deficient lymphomas.  Moreover, combining CRISPR/Cas9 and chemical screenings, I propose to identify novel factors sustaining the growth of lymphoma cells that lost BCR expression. Overall, this research proposal will address relevant, yet unanswered questions in the biology of B cell lymphomas, providing a better understanding into the complexity of signaling competence in normal and transformed B cells, and identifying novel factors promoting independence from BCR signaling, to be exploited as therapeutic targets for the treatment of B cell lymphomas resistant to BCR-specific inhibitors.
Growth of Indonesian Infants Compared With World Health Organization Growth Standards

The ability of the World Health Organization (WHO) growth standards to represent the growth of South East Asian infants has been questioned. The aim of this study was to provide contemporary data on the growth of Indonesian breast-fed and formula-fed infants, compared with the WHO growth standards.A prospective cohort study of 160 normal healthy infants was undertaken in a suburban area of South Jakarta, Indonesia. Infants from 2 to 6 weeks of age were recruited, and they consumed exclusively either breast milk or infant formula for at least 6 months, with follow-up until 12 months of age.Overall, the infants in the present study were lighter (weight-for-age), were shorter (length-for-age), and had smaller head circumferences (head circumference-for-age) than the average WHO Growth Reference Study population but were of similar proportion (weight-for-length). Compared with the WHO Growth Reference Study, the z scores for weight-for-age, length-for-age, and head circumference-for-age in the Indonesian children fell from birth to 6 weeks of age and then increased until 3 months of age in both the breast-fed and the formula-fed infants. At 6 weeks of age, the weight-for-age z scores fell below -2 standard deviations for 16 (20.5%) breast-fed and 40 (51.3%) formula-fed infants, and the length-for-age z scores fell below -2 standard deviations for 31 (39.7%) breast-fed and 41 (52.6%) formula-fed infants.The WHO growth standards do not reflect the growth of the present cohort of Indonesian infants and may overestimate the levels of underweight and stunted children.
[Effect of propolis against radiation-induced oral mucositis in rats].

This study aims to investigate whether propolis has a protective role in oral mucosal damage induced by radiotherapy applied to head-neck region, using quantitative, biochemical and histopathological approaches.Forty eight Wistar-Albino adult female rats at eight weeks of age and weighing 213±27 grams were included in this study and randomly divided into six groups: Group 1: control, group 2: only irradiated rats, group 3: irradiated rats with propolis administration at 50 mg/kg/day, group 4: irradiated rats with propolis administration at 100 mg/kg/day, group 5: only propolis administration at 50 mg/kg/day, group 6: only propolis administration at 100 mg/kg/day. The first dose of propolis was administered before 30 minutes irradiation and the other doses after irradiation once daily for seven days by topical application. Radiotherapy was applied to the total cranium by single fraction at a dose of 18 Gy. The mucositis degrees and body weights of the animals were measured throughout the experiment. On the 7th day of study, blood samples were taken from the rats under ketamine anesthesia and then the rats were sacrificed and tongue tissues samples were taken. Complete blood count and biochemical and antioxidant activities were analysed in the blood samples. The tongue samples were microscopically examined.Radiotherapy group had a decrease in body weight and neutrophil count, and an increase in oral mucositis as compared with the control group (p<0.001). Moreover, an increase in plasma malondialdehyde concentrations (p<0.001) and significant decreases in catalase and superoxide dismutase activities (p<0.001) were observed in irradiation-alone group when compared to the control group. Propolis administered irradiated rat groups showed a dose-dependent normalization in quantitative, biochemical and histopathological parameters when compared with the irradiation-alone group.The results showed that propolis is effective in reducing the severity of oral mucositis induced by head-and-neck irradiation.
France Italy online to increase the competitiveness of SMEs

This project stems from an understanding of the need of SMEs in the cooperation area to be supported in their first years of activity with high value added services, allowing them to remain on the market.
 The experience developed as part of the Fr.I.Net2 project shows that micro enterprises and SMEs feel the need for more services in areas that are fundamental for their survival, such as positioning on foreign markets and the ability to generate innovation.
 The project aims to structure a specialised technical assistance service for SMEs/scale-ups/gazelles in the cross-border area, that operate in the priority supply chains of the Maritime Programme; this assistance service is based on the experience and skills developed as part of the previous “Frinet” and “Frinet2” projects.
 The project aims to create a cross-border network of experts and organisations that are able to offer advanced technology and services for the aforementioned types of company operating in the priority supply chains of the Programme. The idea of this network is to increase companies’ ability to generate innovation and to consolidate their position on foreign markets.
 Specialised assistance will be focused on key aspects linked to these specialist areas, such as: IPR, digitalisation and ICT use, smart manufacturing, risk finance, identification of foreign markets/customers.
 The project aims to enhance the results achieved by the Fr.I.Net2 project, in particular: 
1. the selected group of experts (which will be updated through a new call for applications).
2. the methodology to establish the Cross-border Centre of Expertise and the related range of services.
 However, the project also innovates the previous project experience by working with new partners (PACA regional chamber) and by including cross-border innovation hubs and research centres and foreign investors among its service providers.
LIGHTING CONTROL METHOD

A method for controlling a light, comprising: providing a first sensor device (11) comprising a first transmitter and a first occupancy sensor;providing a lighting controller (1) comprising a receiver and a second sensor; and transmitting an occupancy signal from the first transmitter to the receiver. The occupancy signal comprises a repeated cycle of transmission phases and silent phases, such that during a transmission phase the transmitter transmits and during a silent phase the transmitter does not transmit. The method further comprises activating the light when the second sensor is triggered; and deactivating the light after a period of time, the length of the period being determined at least in part by the occupancy signal transmitted by the first transmitter.
Design and system identification of a micro coaxial helicopter testbed

This paper outlines design and system identification of a micro coaxial helicopter testbed. A commercially available micro coaxial helicopter is modified to include onboard avionics that enable realtime inertial measurements, multi-channel servo control, and bidirectional communication with a basestation computer. Recorded input-output flight data is used to identify the helicopter's attitude dynamics at the hovering condition in both time and frequency-domains, which are modelled as a parametrised MIMO linear time-invariant system. The fidelity of the identified dynamic models is validated by various residual analyses, and the identified parameters are compared with those of single-rotor helicopters from existing literature. The comparison shows that the newly identified models reveal inherent dynamic characteristics of the micro coaxial helicopter testbed. The identified models will serve as the basis for future design of model-based controllers and aerodynamic disturbance estimation.
Neurodevelopmental outcome of full-term small-for-gestational-age infants with normal placental function

To evaluate the 2-year neurodevelopmental outcome of full-term, small-for-gestational-age (SGA) newborns with normal placental function, according to current criteria based on umbilical artery Doppler findings.A cohort of consecutive full-term, SGA newborns with normal prenatal umbilical artery Doppler was compared with a group of full-term, appropriate-for-gestational-age (AGA) infants sampled from our general neonatal population. Neurodevelopmental outcome was evaluated at 24 months' corrected age using the Bayley Scales of Infant and Toddler Development, 3(rd) Edition (Bayley-III), which evaluates cognitive, language, motor, social-emotional and adaptive competencies. The effect of the study group on each domain was adjusted with MANCOVA and logistic regression for gestational age at delivery, socioeconomic status, gender, tobacco smoking and breastfeeding.A total of 223 infants (112 SGA and 111 AGA) were included. The groups differed significantly with respect to socioeconomic status and gestational age at delivery. All studied neurodevelopmental domains were poorer in the SGA group, reaching significance for the cognitive (92.9 vs 100.2, adjusted P = 0.027), language (94.7 vs 101, adjusted P = 0.025), motor (94.2 vs 100, adjusted P = 0.027) and adaptive (89.2 vs 96.5, adjusted P = 0.012) scores. Likewise, the SGA group had a higher risk of low scores in language (odds ratio (OR) = 2.63; adjusted P = 0.045) and adaptive (OR = 2.72; adjusted P = 0.009) domains.Compared with normal-sized babies, full-term SGA infants, without placental insufficiency defined according to currently used criteria, have lower 2-year neurodevelopmental scores. These data challenge the concept that SGA fetuses with normal umbilical artery Doppler are 'constitutionally small' but otherwise completely normal.
Disequilibirum metamorphism of stressed lithosphere

Most changes in mineralogy, density, and rheology of the Earth’s lithosphere take place by metamorphism, whereby rocks evolve through interactions between minerals and fluids. These changes are coupled with a large range of geodynamic processes and they have first order effects on the global geochemical cycles of a large number of elements.
In the presence of fluids, metamorphic reactions are fast compared to tectonically induced changes in pressure and temperature. Hence, during fluid-producing metamorphism, rocks evolve through near-equilibrium states.  However, much of the Earth’s lower and middle crust, and a significant fraction of the upper mantle do not contain free fluids. These parts of the lithosphere exist in a metastable state and are mechanically strong. When subject to changing temperature and pressure conditions at plate boundaries or elsewhere, these rocks do not react until exposed to externally derived fluids. 
Metamorphism of such rocks consumes fluids, and takes place far from equilibrium through a complex coupling between fluid migration, chemical reactions, and deformation processes. This disequilibrium metamorphism is characterized by fast reaction rates, release of large amounts of energy in the form of heat and work, and a strong coupling to far-field tectonic stress. 
Our overarching goal is to provide the first quantitative physics-based model of disequilibrium metamorphism that properly connects fluid-rock interactions at the micro and nano-meter scale to lithosphere scale stresses. This model will include quantification of the forces required to squeeze fluids out of grain-grain contacts for geologically relevant materials (Objective 1), a new experimentally based model describing how the progress of volatilization reactions depends on tectonic stress (Objective 2), and testing of this model by analyzing the kinetics of a natural serpentinization process through the Oman Ophiolite Drilling Project (Objective 3).
Searching Desktop Files Based on Access Logs

People often meet trouble in searching a desktop file when they can not remember exact words of its filename. In this paper, we firstly propose an algorithm to generate access logs by monitoring desktop operations and implement a prototype. By running it in several computers of selected participants we collected a data set of access logs. Then we propose a graph model to represent personal desktop files and their relationships, and highlight two file relationships(content relationship and time relationship) to help users search desktop files. Based on the graph model, we propose a desktop search method, and the experimental results show the feasibility and effectiveness of our methods.
Zikaction: preparedness, research and action network on maternal-paediatric axis of zikv infection in latin america and the caribbean

ZIKAction proposes to set up a multidisciplinary research network across Latin America with a focus on maternal and child health to coordinate and implement urgent research against the current ZIKV outbreak and lay the foundation for a preparedness research network against future emerging severe infectious threats in these vulnerable populations. Our Consortium brings together Latin American and European leaders in paediatric infectious disease research, including virologists, epidemiologists, immunologists and obstetric, neonatal and paediatric practitioners, all with a wealth of experience in vertical transmission (VT) studies, a group uniquely placed to evaluate the potentially causative relationship between ZIKV and severe reported complications. ZIKAction will collect data from prospective cohorts of pregnant women and infants to assess ZIKV complications with the necessary level of evidence which is currently lacking. Complementary work in virology will take advantage of repeated biological samples from these cohorts, while pathogenesis studies on animal models will elucidate risk factors and mechanisms of VT. Partners’ experience in conducting trials among pregnant women and children and close contact with other relevant researchers will allow rapid launch of additional interventional studies, including the addition of sites and partners, to address remaining research gaps against ZIKV. Recognizing the breadth and complexity of the research questions presented by the current ZIKV epidemic and the potential for future severe emerging infectious threats, ZIKAction will actively seek out collaborations with relevant initiatives already existing or under development to maximize synergy and avoid duplication of efforts. Our focus on vertical transmission and maternal and child health would nicely complement a range of other activities including clinical and laboratory studies in the general population, surveillance, and work in public health and prevention.
Advances in the Omicron variant development

Severe acute respiratory syndrome coronavirus (SARS-CoV)-2 has spread worldwide, leading the World Health Organization (WHO) to declare a pandemic, on 11 March 2020. Variants of concern have appeared at regular intervals-Alpha, Beta, Gamma, Delta, and now Omicron. Omicron variant, first identified in Botswana in November 2021, is rapidly becoming the dominant circulating variant. In this review, we provide an overview regarding the molecular profile of the Omicron variant, epidemiology, transmissibility, the impact on vaccines, as well as vaccine escape, and finally, we report the pharmacological agents able to block the endocellular entry of SARS-CoV-2 or to inhibit its viral replication. The Omicron has more than 50 mutations, of which the spike protein has 26-35 amino acids different from the original SARS-CoV-2 virus or the Delta, some of which are associated with humoral immune escape potential and greater transmissibility. Omicron has a significant growth advantage over Delta, leading to rapid spread with higher incidence levels. The disease so far has been mild compared to the Delta. The two vaccination doses offer little or no protection against Omicron infection while the booster doses provide significant protection against mild illness and likely offer even greater levels of protection against serious illness. Recently, new oral antiviral agents such as molnupiravir and paxlovid have been approved and represent important therapeutic alternatives to antiviral remdesivir. In addition, monoclonal antibodies such as casirivimab/imdevimab bind different epitopes of the spike protein receptor; is this class of drugs effective against the Omicron variant? However, more research is needed to define whether Omicron is indeed more infectious and whether the vaccines, monoclonal antibodies, and antivirals currently available are effective.