SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Abstract 12088: cMyBP-C’S Interaction With Actin is Critical to Maintain Diastolic Function in vivo

Background: cMyBPC’s interaction with actin is critical to maintain diastolic function in vivo Rationale: Extensive studies demonstrate that cardiac myosin binding protein C (cMyBP-C) is a critical mediator of diastolic function through its interaction with actin, myosin and titin. The precise molecular mechanisms underlying the protein’s function remain elusive as cMyBP-C’s structural domains responsible for actin and/or myosin interaction are ill-defined and the physiological consequences of these filament interactions are unknown. Objective: In the present study, we made transgenic mice that lacked cMyBP-C’s actin and/or the head region of the myosin heavy chain (S2-MyHC) sites in order to better understand the molecular mechanisms of cMyBPC-mediated regulation of cardiac contraction, particularly diastolic function. Methods and Results: Using a combination of genetics and functional assays, we defined cMyBP-C’s N-terminal structural domains as well as the critical residues necessary or sufficient to mediate interactions with actin and/or S2-MyHC. Using genetic experiments, we first confirmed that mutation of three lysines to alanines in the C1 domain abolished actin binding (cMyBP-C Act- ). Similarly, mutation of three arginines to alanines in the “m” domain abolished S2-MyHC binding (cMyBP-C S2- ). To determine the functional roles of these sites in vivo, we generated transgenic lines in which normal cMyBP-C was replaced by either cMyBP-C Act-,S2- or wild type (cMyBP-C WT ), transgenically-encoded cMyBP-C. Mutant protein was completely substituted for endogenous cMyBP-C by breeding the transgenes into a cMyBP-C null background. The cMyBP-C Act-,S2- mice developed significant cardiac hypertrophy with myofibrillar disarray and fibrosis. Echocardiographic Doppler measurements showed that cMyBP-C Act-,S2- mice develop both diastolic and systolic dysfunction. In contrast, the cMyBP-C WT Tg line showed normal cardiac structure and function. Conclusions: These results suggest that the cMyBP-C’s interactions with both actin/S2-MyHC are structurally important to preserve normal cardiac contractility and particularly, cMyBP-C’s interaction with actin is indispensable for normal diastolic function.
Enhancing innovation management capacity of catalan small and medium enterprises 2017-2018

Horizon 2020 call “Enhancing the innovation management capacity of SMEs” proposes advising services to SMEs with the
objective of increasing and accelerating the economic returns from innovation. The current proposal fully describes these
services and proves ACCIÓ’s capacity to successfully deliver them.
The services will be provided to two specific groups of enterprises: beneficiaries of the SME instrument and, SMEs with significant innovation activities and a high potential for internationalisation.
As the current coordinator of the Catalan node of the EEN (also for 2015-2020), ACCIÓ is specialised in promoting
innovation and internationalisation among SMEs and has implemented several successful programmes over the last 20
years; for instance it is currently providing advise services for the period 2015-2016 with IMPRove, Innovation Health Check (IHC) and KAM methodologies with an EU financed project called INNCAT.
The experience obtained, especially since the implementation of INNCAT, has given to our team of experts a deeper
knowledge of these services and therefore we are proposing that a minimum of 80 services will be provided in the period of
2017-2018 for enhancing the innovation management capacity of SMEs. It is 42% more services than INNCAT1516.
The proposed staff is fully committed to deliver the proposed services and is trained in IMPR3ove methodology and Innovation Health Check (IHC) and have a broad and extensive expertise in innovation and business support and, management. Moreover, 6 of the proposed 9 staff members have intervened in the implementation of INNCAT for the delivery of KAM and IMPR3ove services during 2014-2016.
Therefore they are fully capable to deliver the services described and successfully advise SMEs.
Strategies to Reduce and Manage Food Waste in Central Europe

Wasting food is not only an ethical and economic issue but it also depletes the environment of limited natural resources. Additionally, methane emissions from improper food waste management cause high greenhouse gas emissions._x000D_
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STREFOWA will address and improve food waste management in selected central European functional urban areas by fostering food waste prevention and treatment, leading to a reduction of environmental impacts (esp. greenhouse gas emissions). Project results will contribute to raising knowledge and implementation capacity regarding food waste management of all target groups along the whole food supply chain (inclunding private persons, local authorities, gastronomes, retailers, teachers, waste management authorities, ...). A real reduction of food waste in different areas and optimisation in food waste treatment will be reached by the:_x000D_
- Implementation of different pilot and demonstration actions;_x000D_
- Establishment of an appropriate transnational stakeholder platform;_x000D_
- Implementation of a web based decision support tool tailored to different users to provide best practice guideline and trainings._x000D_
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The focus on the central Europe region is new and not least due to the common cultural and culinary roots reasonable. The innovative approach is not only to focus either on food waste prevention or waste treatment but to see the waste management as a whole following the waste hierarchy as described in the European waste framework directive. Because of close business ties within the central European region e.g. in retail for NGOs a transnational cooperation and implementation of a transnational multi-stakeholder network guarantees an added value compared to single projects._x000D_
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Information added on 2020-05-18, regarding the mitigation of the effects of COVID-19 (the coronavirus pandemic that started in 2019) (English language only): Food waste was already a pressing issue before, and panic buying after the lock-down made it even worse. The guidelines for consumers developed by STREFOWA are now more useful than ever. They help citizens to better plan buying and organising groceries at home, so that nothing ends up in the bin.
Circulating and tumor-infiltrating Tim-3 in patients with colorectal cancer

T-cell exhaustion represents a progressive loss of T-cell function. The inhibitory receptor PD-1 is known to negatively regulate CD8+ T cell responses directed against tumor antigen, but the blockades of PD-1 pathway didn't show the objective responses in patients with colorectal cancer (CRC). Thus, further exploring the molecular mechanism responsible for inducing T-cell dysfunction in CRC patients may reveal effective strategies for immune therapy. This study aims to characterize co-inhibitory receptors on T cells in CRC patients to identify novel targets for immunotherapy. In this study, peripheral blood samples from 20 healthy controls and 54 consented CRC patients, and tumor and matched paraneoplastic tissues from 7 patients with advanced CRC, subjected to multicolor flow cytometric analysis of the expression of PD-1 and Tim-3 receptors on CD8+ T cells. It was found that CRC patients presented with significantly higher levels of circulating Tim-3+PD-1+CD8+ T cells compared to the healthy controls (medians of 3.12% and 1.99%, respectively, p = 0.0403). A similar increase of Tim-3+PD-1+CD8+ T cells was also observed in the tumor tissues compared to paraneoplastic tussues. Tim-3+PD-1+CD8+ T cells in tumor tissues produced even less cytokine than that in paraneoplastic tissues. Functional ex vivo experiments showed that Tim-3+PD-1+CD8+ T cells produced significantly less IFN-γ than Tim-3-PD-1-CD8+ T cells, followed by Tim-3+PD-1-CD8+ T cells, and Tim-3-PD-1+CD8+ T cells, indicating a stronger inhibition of IFN-γ production of Tim-3+CD8+ T cells . It is also found in this study that Tim-3+PD-1+CD8+ T cell increase in circulation was correlated with clinical cancer stage but not histologic grade and serum concentrations of cancer biomarker CEA. Our results indicate that upregulation of the inhibitory receptor Tim-3 may restrict T cell responses in CRC patients, and therefore blockage of Tim-3 and thus restoring T cell responses may be a potential therapeutic approach for CRC patients.
ANFIS-based approach for predicting sediment transport in clean sewer

The necessity of sewers to carry sediment has been recognized for many years. Typically, old sewage systems were designated based on self-cleansing concept where there is no deposition in sewer. These codes were applicable to non-cohesive sediments (typically storm sewers). This study presents adaptive neuro-fuzzy inference system (ANFIS), which is a combination of neural network and fuzzy logic, as an alternative approach to predict the functional relationships of sediment transport in sewer pipe systems. The proposed relationship can be applied to different boundaries with partially full flow. The present ANFIS approach gives satisfactory results (r(2) = 0.98 and RMSE = 0.002431) compared to the existing predictor.
Interaction of cationic hydroxyethylcellulose (JR400) and cationic hydrophobically modified hydroxyethylcellulose (LM200) with the amino-acid based anionic amphiphile Sodium N-Dodecanoyl Sarcosinate (SDDS) in aqueous medium

Abstract Interaction of an ionic amphiphile with an oppositely charged polyelectrolyte may dramatically alter the physicochemistry of the polymer in solution. Exploration of the macro and microscopic details of such processes is a topic of contemporary interest. In this study, results of interaction of the anionic amphiphile, Sodium N-Dodecanoyl Sarcosinate (SDDS) with the cationic hydroxyethylcellulose, JR400 and hydrophobically modified cationic hydroxyethylcellulose, LM400 at the air/water interface and in the bulk over a fair range of concentration in the absence and presence of salt are presented. At a very low concentration, SDDS monomers interact with the polymer; above the critical aggregation concentration (CAC), small micelle like aggregates form complexes with the polymer. The complex, thereafter, self-associates to form a turbid coacervate phase. At increased [SDDS], the turbidity decreases by way of disintegration of the coacervates, and the solution becomes clear. The salt, NaCl affects the SDDS–polymer interaction. The amphiphile interaction with mixed JR400 and LM200 also produces characteristic interfacial and bulk features. Different physical methods are employed to probe the interaction process and an attempt for correlation of the results has been made.
Achieving a Decision Paradigm for Distributed Warfare Resource Management

Abstract The ability to optimally manage distributed warfare assets for collaborative operation significantly increases our military advantage. The primary results include enhanced situational awareness and improvements in fire control, engagement support, operational planning, combat reaction times, threat prioritization, and the list continues. Bettering the use of sensors and weapons in concert with one another–effectively creating a system of distributed systems–provides major payoffs. The effectiveness of managing distributed resources depends on the ability to make complex decisions [1]. The complexity is due in part to the circuitous nature of fusing data from multiple sensor sources to provide a representation of the operational environment from which to redirect sensors for further information optimization and from which to base military operations. The “goodness” of such complex decisions depends on the “goodness” of the information available and the understanding of the situation from a “big picture” perspective. This paper explores distributed resource management (RM) from a decision-based perspective. With an objective of enabling a collaborative system of systems (SoS), a systems approach is proposed to implement a decision paradigm that extends from system conception to operations.
STRUCTURAL FLANGE CONNECTION SYSTEM AND METHOD

A structural flange connection system and method that utilizes structural flanges having a standard bolted connection and a mechanical bond to effectively manage and assist the retention of bolt preloads and substantially eliminate movement between the flange faces due to a reduction in the need for friction load being generated by the bolt clamping force in the flange connection. The structural flanges of the structural flange connection system and method each include an outer rim and a flange lip having a face and a shoulder. The structural flange connection system and method may be utilized in the manufacture and installation of a wind turbine tower, which may be made up of one or more tower sections, and each tower section may terminate in structural flanges of the structural flange connection system and method. When properly aligned, the structural flanges may be bolted together. When each tower section is properly aligned and bolted, the mechanical bond of the structural flanges is also joined together. Such manufacture of the wind turbine tower may occur in the field during installation of the wind turbine tower.
FATIGUE RESISTANT THREAD PROFILE WITH COMBINED CURVE ROUNDING

A threaded connector that includes a pin end having external threads and a box end having internal threads that are complementary to the external threads has a thread profile that defines at least a portion of either or both of the internal threads and the external threads. The thread profile may include a thread root connecting a first flank to a second flank and the thread root may be at least partially defined by a plurality of tangentially interconnected radii. The plurality of radii may include at least a medial radius, a first distal radius on one side of the medial radius, and a second distal radius on the another side of the medial radius. The medial radius may be larger than the first and the second distal radius. Alternatively, the thread profile includes a thread root connecting a first flank to a second flank that is at least partially defined by a plurality of radii, each radius having a different length and each defining a circular arc.
Resilient synthetic vision for advanced control tower air navigation service provision

The increasing interest in Synthetic Vision (SV) and Augmented Reality (AR) technologies has led various analysts to positively esteem the adoption of new tools enabling pilots and controllers to seamlessly operate under Visual Meteorological Conditions and Instrument Meteorological Conditions. The RETINA project will investigate the potential and applicability of SV tools and Virtual/Augmented Reality (V/AR) display techniques for the Air Traffic Control (ATC) service provision by the airport control tower. Within the project, several concepts and basic principles that have been observed in different areas (e.g. Remote Tower, Synthetic Vision Systems, AR, Information Technologies, etc.) will be brought to the level of maturity required for the Applied Research that will be conducted in SESAR V1-V3 (Applied Research, Industrial Research & Validation). To this end, a 3D airport model will be developed, along with V/AR based human-computer interfaces. The digital model will provide controllers with precise positioning for both aerial and terrestrial objects, drawing information from multiple, simulated, data sources, such as the System Wide Information Management (SWIM) network, Remote Towers sensing technologies and other well-established surveillance systems – e.g. Airport Surveillance Radar (ASR) and the Surface Movement Radar (SMR). The interface design will be based on the Ecological Interface Design approach. Finally, the project will investigate the impact of the newly conceived tools on the control tower air traffic management procedures. On the whole, those tasks that are negatively affected by poor visibility conditions, such as bad weather, fog, smoke, dust or any other kind of environmental occlusion, will become weather-independent. The RETINA project primarily relates to SESAR ER-06-2015 - High Performing Airport Operations - Improved Visualisation and Awareness, but also has a secondary relationship to SESAR ER-03-2015 - Information Management in ATM.
BioTISCH

In a molecular biology lab, scientists often need to execute strictly defined sequences of operations, typically mixing specific amounts of reagents. The exact steps require information from various sources, like manuals, websites and own notes. Direct access to a computer at the bench would be highly desirable but is rarely implemented, as computers do not fit well into a wet lab environment. In this paper, we present BioTISCH, an interactive workbench for molecular biology laboratories. We show a prototypical setup of an interactive table which provides a sterile user interface for access to existing documentation and for common tasks such as unit conversions. The example illustrates that interactive tables blend very well into a modern biological laboratory and could improve access and exchange of information in this environment.
Une sociohistoire des critiques numériques

Cet article de présentation du dossier thématique rappelle que la multiplication des remises en cause de la Silicon Valley s’inscrit dans une histoire plus longue des mobilisations sociales et des théories critiques de l’informatique et des réseaux. L’objet du dossier est de relire l’histoire du numérique à travers les lunettes de la critique. L’historiographie et la sociologie de ces critiques permettent de reconstituer les étapes de construction du numérique en tant qu’objet homogène, en dépit d’une multitude de pratiques, d’espaces et de sens. Elles éclairent également les thèmes qui ont accompagné ce développement. Cette introduction présente ce faisant les grandes lignes d’une sociohistoire des critiques du numérique depuis la fin des années 1970 ; elle souligne à la fois la continuité et le renouvellement des motifs critiques depuis cette période jusqu’au techlash actuel. À partir de quoi, le dossier propose des outils analytiques, qui témoignent de l’influence de lignages philosophiques et politiques plus anciens tels que la critique sociale, la critique libérale et la critique écologique. L’étude des critiques numériques rejoue ainsi l’opposition classique entre critique interne et critique externe. L’article propose enfin une réflexion sur les « numérisations de la critique ».
INFORMATION PROCESSING DEVICE, INFORMATION PROCESSING METHOD, AND PROGRAM

An information processing apparatus that outputs information for identifying a combination of batteries including a solar battery, a fuel cell, and a storage battery includes a storage unit and a control unit. The storage unit stores effects of each of solar batteries, fuel cells, and storage batteries constituting the combinations of batteries from an environmental perspective, a safety perspective, and an economical perspective. The control unit performs control such that information for identifying, among the combinations of batteries, a combination determined on a basis of the effects of each of the solar batteries, the fuel cells, and the storage batteries constituting the combinations of batteries from the environmental perspective, the safety perspective, and the economical perspective is output.
MAnagement Tools and Relations for Interregional Organisation to Strengthening Co-operation in AAP

Regions on the fringes of long established, new or forthcoming EU Member States, in particular, are in need of transnational collaborations and development. The co-operation area of the MATRIOSCA-AAP project, the "Adria-Alpe-Pannonia" (AAP) space, comprises old and new EU Member States as well as candidate countries. It is characterised by strong regional and cultural diversity. The MATRIOSCA-AAP project concentrates on territories located at the interface of these countries and involves regions from Austria, Italy, Hungary, and Slovenia as well as the candidate country Croatia. In recent years the amount of co-operation on the project level in the AAP region has increased considerably and many new, but yet fragmented contacts have been established. The aim of the project is to promote an integrated and co-ordinated development of the AAP region by overcoming the problem of the numerous, but unorganised contacts on political, administrative and expert level. The project should also help to intensify collaboration efforts regarding development matters in the AAP co-operation area. Also other administrations of the region, like the Varazdin County (Croatia) and the Autonomous Province of Vojvodina (Serbia) contribute to the successful project implementation
The US National Tuberculosis Surveillance System: A Descriptive Assessment of the Completeness and Consistency of Data Reported from 2008 to 2012

In 2009, the Tuberculosis (TB) Information Management System transitioned into the National TB Surveillance System to allow use of 4 different types of electronic reporting schemes: state-built, commercial, and 2 schemes developed by the Centers for Disease Control and Prevention. Simultaneously, the reporting form was revised to include additional data fields.Describe data completeness for the years 2008-2012 and determine the impact of surveillance changes.Data were categorized into subgroups and assessed for completeness (eg, the percentage of patients dead at diagnosis who had a date of death reported) and consistency (eg, the percentage of patients alive at diagnosis who erroneously had a date of death reported). Reporting jurisdictions were grouped to examine differences by reporting scheme.Each year less than 1% of reported cases had missing information for country of origin, race, or ethnicity. Patients reported as dead at diagnosis had death date (a new data field) missing for 3.6% in 2009 and 4.4% in 2012. From 2010 to 2012, 313 cases (1%) reported as alive at diagnosis had a death date and all of these were reported through state-built or commercial systems. The completeness of reporting for guardian country of birth for pediatric patients (a new data field) ranged from 84% in 2009 to 88.2% in 2011.Despite major changes, completeness has remained high for most data elements in TB surveillance. However, some data fields introduced in 2009 remain incomplete; continued training is needed to improve national TB surveillance data.
Lexical Gap in English - Vietnamese Machine Translation: What to Do?

In English – Vietnamese machine translation (EVMT) project at Ho Chi Minh City University of Technology there are some problems that cause the system to malfunction. One of the most undesired phenomena is lexical gap. A lexical gap occurs in case of lacking Vietnamese equivalent word to English word. There are some approaches to this obstacle. Some researchers prefer replacing lexical gap by its nearest meaning word. However, in out project there isn’t a conception database for Vietnamese word that helps to find acceptable word to lexical gap. Our approach for lexical gap establishes a word – to - phrase model for EVMT. Naive replacements of word by phrase keep semantic information as much as possible, however, lead translated sentences to syntactic mismatch, and therefore ungrammatical text. We restructure target sentence using phrase in dictionary as template of formal phrase structure in the model with some algorithms to keep target sentence be grammatical. This approach improves rule - based English Vietnamese machine translation.