SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Agenesis of the ductus venosus – an irrelevant anomaly or a severe clinical problem?

Ductus venosus is the fetal blood vessel connecting the abdominal portion of the umbilical vein with the inferior vena cava. Numerous studies have confirmed the important role of this vessel in fetal circulation. There are, however cases when finding the ductus venosus during an ultrasound examination is impossible.The objective of the study was to assess the fate of fetuses with known ductus venosus agenesis and its severity in fetal life.17 fetuses from singleton pregnancies with agenesis of the ductus venosus were observed and followed up.A total of 3 intrauterine deaths, preceded by fetal hydrops and signs of heart failure, were observed in the study group. One newborn required cardiac care after birth. In the majority of cases with ductus venosus agenesis, where no accompanying developmental anomalies were found, prognosis for the fetus and the newborn was good.Cases of ductus venosus agenesis should be directed to and followed up in referral centers, where adequate diagnostic and therapeutic procedures can be undertaken.
The effects of CO2 gas stunning on meat quality of cattle compared with captive bolt stunning

The aim of this study is to assess the effect of CO2 gas stunning which has not been conducted until now in comparison with captive bolt stunning on the meat quality of cattle. A total of 40 steers were slaughtered following two stunning processes: CO2 gas stunning (n=20), exposure at 70% CO2 gas atmosphere for 140 sec; and captive bolt stunning (CBS, n=20). The slaughtered steers were classified into Group A (620–710 kg) and Group B (720–790 kg) by their live weight. CO2 gas stunning decreases pH value (p<0.05) but increases lightness (p<0.001) and sarcomere length (p<0.001 and p<0.01 for Group A and Group B, respectively) in all live weight groups. Drip loss was increased with CO2 gas stunning in Group A (620–710 kg of live weight) (p<0.05), whereas WBSF was decreased with CO2 gas stunning in Group B (720–790 kg of live weight) (p<0.001). Therefore, CO2 gas stunning negatively affects muscle pH and water-holding capacity in steers but CO2 gas stunning can improve the tenderness and lightness compared with captive bolt stunning in cattle.
LA-ICP-MS U-Pb dating of Carboniferous ash layers in the Cantabrian Zone (N Spain): stratigraphic implications

Seven centimetre-thick volcanic ash-fall layers interbedded within the thick Carboniferous successions of the Cantabrian Zone in northern Spain were dated by U–Pb zircon laser ablation inductively coupled plasma mass spectrometry across an interval ranging from Visean to Kasimovian, thus covering most of the Carboniferous period. All these ash layers occur in fossiliferous successions, allowing us to insert the radiometric data within a well-constrained biostratigraphic framework. Considering the analytical uncertainty, the obtained ages match the ages inferred from the conodont biostratigraphy established in the Mississippian succession (which hosts the oldest two ash layers, Visean in age), and the fusuline and mega- and microflora data from the strata hosting the Moscovian and Kasimovian (Westphalian–Stephanian) tonsteins. The age of a Langsettian tonstein along with data provided by several papers stating that in the Cantabrian Zone Langsettian floras were contemporaneous with lowermost Moscovian fusulines suggest that Langsettian floras could have been younger in Spain than in other areas. Our absolute ages provide new constraints not only for the correlation of the Carboniferous successions of the Cantabrian Zone with time-equivalent reference successions in other parts of the world but also for calibrating the Carboniferous global chronostratigraphic units based on marine fossils with the West European regional units. Supplementary material: Stratigraphic position and biostratigraphic information on the studied ash-fall layers, analytical methods and geochronological results are available at https://doi.org/10.6084/m9.figshare.c.3768701
Together for the promotion of a sustainable energy

The aim is to gather and share knowledge and practices of professionals, local communities, and citizens of nine Alpine Space regions in the promotion of a natural local resource:  wood-fuel. Precisely, develop actions to:
- Have them know each other so that they work together
- Put at their disposal the knowledge through an international web-server
- Make this local energy known by the public
- Set up a marketing campaign through the extension of the European wood energy Road© in the Alps
- Study the feasibility of industrial structures of wood fuels production (firewood logs, chips and pellets) and promote them to deal with the demand of great national fuel distributors
- Set up bases of professional trainings about this sustainable energy by using new communication technologies
This project is a great opportunity for the regional contributors to confront their experiences and therefore to learn, progress, and contribute to a better physical management of the Alpine Space thanks to a renewable energy.
SYSTEM AND METHOD FOR SAND AND INFLOW CONTROL

A system and methodology utilizes a technique for filtering sand. For example, a sand control system may be provided with a base pipe having a non-permeable section and a permeable section in which the permeable section is created via at least one opening formed laterally through a wall of the base pipe. The sand control system also comprises at least one drainage tube positioned along an exterior of the base pipe and coupled to the base pipe in fluid communication with the at least one opening. The drainage tube is permeable and enables the inflow of fluid while preventing the influx of sand. The inflowing fluid is delivered along an interior of the drainage tube and through the opening into an interior of the base pipe for production.
Identity management on social media by diasporic lgbtqs

The internet, and social media in particular, create new opportunities and pose new challenges for the ways people think about themselves as well as manage the expressions of their identities. In this research project I aim to enrich our knowledge about the transformations of identity in the new media landscape of the early XXI century by investigating those transformations from the perspective of diasporic LGBTQs, that is, lesbian, gay, bisexual, transgender and queer people. I will focus on the latest theories on social media and identity  about 1) fixating the fragmented self (van Zoonen 2013), 2) collapsed contexts (boyd 2011) and 3) the multiplication of contexts (Papacharissi 2011), by investigating those phenomena from the perspective of Polish post-accession immigrants to the UK. I will examine what diasporic LGBTQs and their social media’s uses can teach us about the relationship between the internet and identity, as well as what opportunities and difficulties social media create to a group that faces different challenges of exclusion and discrimination. I will first use a quantitative survey to map the diversity of social media used by Polish LGBTQs in the UK. However, because I am primarily interested in meanings of daily media practices, it is qualitative methods, and in-depth interviews in particular, which will form the core of my methodological toolkit. At the same time, to trigger more and better quality data I will combine traditional qualitative methods with such innovative approaches as think-aloud protocols (which require from participants to talk about the activity in which they are involved) and digital methods (the methods of the medium under scrutiny).
Next-Generation quantum light-matter interfaces based on atom arrays and nanophotonic waveguides

The fellow will investigate the use of atom arrays as next-generation quantum light-matter interfaces. He will be hosted by the Institute of Photonic Sciences in Barcelona, Spain. At ICFO, he will be integrated in the Theoretical Quantum-Nano Physics group under the supervision of Prof. Darrick Chang.

Quantum atom-light interfaces have the potential to significantly impact all four domains of Quantum Computation, Communication, Metrology, and Simulation prioritized by the European Quantum Technologies Roadmap. All these future quantum technologies require the ability to efficiently interface light and matter at the level of single quanta. However, despite decades of research in quantum optics, current light-matter interfaces still struggle to meet this requirement at the level needed for robust applications.

LuMiNouS is a multidisciplinary, theoretical study of a novel approach based on one-dimensional subwavelength arrays of atoms near nanophotonic waveguides, which are now becoming available experimentally. We aim to show that the spatial ordering and low dimensionality give rise to powerful, previously unexploited interference effects. This new paradigm promises exponential improvements in the fidelity of quantum information processing protocols. LuMiNouS on one hand aims to develop novel protocols with dramatically better error scalings than currently known approaches, and on the other hand will remove the disconnect between theory and experiment by understanding and exploiting real-world complexities.

To reach the first objective, we will, in particular, focus on using atom arrays to significantly improve the performance of quantum repeaters, and on realizing high-fidelity interactions between individual photons, a prerequisite for realizing coherent photon-photon gates. Our efforts towards the second objective will be focused on mitigating imperfect lattice filling, and exploiting the atoms' quantized motion as a powerful, previously untapped resource.
Interactive Alpine Museum

iAlp aims to improve the touristic attractivity of Alpes ‘area, thorough a networking of shared values of private collections conserved at the Montagne National Museum of Turin and the Alpine Museum of Chamonix, participating at an experimentation of new cultural touristic products based on innovative technologies. Both cities possess collections and historical documents on Montagne and Alpinism with an international relevance. It’s important to preserve them but also to use their potentialities to enrich the touristic offer of Alpines territories.
A New Concept Design of Ducted Fan VTOL Based on Torque Balance

This paper put the emphasis on the computation and analysis of the lift characteristics of the ducted fan S\VTOL aircraft. By applying the modified momentum-profile theory, the modified momentum-profile-theory model of ducted propeller is proposed which will be used in the concept design. CFD numerical simulation is carried out for a certain ducted tail rotor in different axial states, and some general rules of aerodynamics change of ducted propeller are obtained in the paper. A second correction is taken after analyzing the induced velocity distribution behind the propeller disk in the wake zone. A new concept of ducted fan based on Torque balance is proposed based on the research of ducted propeller. The initial optimization of the overall designing parameters is conducted in overall design level.
Mechanisms of Histone Modifications

Abstract The genome size is, on average, significantly larger in eukaryotes than in prokaryotes. This, on one hand contributed to the acquisition of a number of advantages. On the other hand, it increased the complexity of regulation of the activity, maintenance, and inheritance of the genomic material. To deal with this complexity, eukaryotic organisms acquired new proteins, called histones that not only allow packaging and protecting the DNA into a higher-order structure called chromatin, but can also regulate the accessibility to and the activity of different parts of the genome. This regulatory function is directed by multiple chemical modifications that can take place on the histones. Here, we introduce the most common histone modifications, the machineries that deposit and remove them, their distribution in the genome, and their role in key cellular processes, with a focus on transcriptional regulation and DNA repair.
Metabolic regulation of conventional dendritic cell development and function

Dendritic cells (DCs) play critical roles in directing innate and adaptive immune responses against infections and cancer. Understanding the mechanisms that control DC development and function may reveal new ways to alter the course of complex human diseases such as cancer. Despite their importance in immunity, some open questions remain in regards to DC basic biology. Two of these questions, in particular, are the subject of this application: 1) DCs are a heterogenous population, which can be subdivided into conventional DC type 1 (cDC1) and 2 (cDC2) subsets. Although their development depends on distinct transcriptional programs, cDC1 and cDC2 descend from a common precursor under the influence of the same growth factor cytokine. What determines cDC1/2 differentiation? 2) Various loss-of-function studies demonstrate that cDC1 are key antigen-presenting cells for initiating CD8+ T cell responses to tumours and some viruses. This primarily relies on a process termed cross-presentation. How is cross-presentation regulated in cDC1? Recent studies indicate that profound changes in cellular metabolism are coupled to immune cell function and may fundamentally underpin cell-fate decisions. Based on previous observations and our own preliminary data, we hypothesise that glycolysis programs cDC1 development and activation, whereas fatty acid metabolism controls the ability of the same cells to cross-present antigens to CD8+ T cells. We propose to define the metabolic programs that drive DC formation and that underlie cDC1 and cDC2 identity and complement this approach with loss and gain-of-function experiments that will allow specific testing of our hypotheses. Globally, these studies will identify novel mechanisms of immune cell control with implications for antiviral and anticancer immunity.
SOCIAL MEMORY AND THE ORIGINS OF MONTE ALBAN

Abstract The founding of Monte Alban marked the beginning of the urban revolution in Oaxaca and a reorganization of Zapotec culture and society, which soon had repercussions among Mixtecs and other Otomangue groups in highland Oaxaca. While local factors contributed to Monte Alban's origins, the architectural expression of the city's core, consisting of a main plaza with leaders’ dwellings on each side and a ceremonial precinct at one end, comes from the Mixe-Zoque area, probably La Venta or highland Chiapas. One of the earliest architectural monuments at Monte Alban is the Danzantes Wall with carved stones that portray founding participants, including many chiefs from valley communities, as interpreted, imagined and remembered by the city's leader or leaders, years after the event. The wall was short-lived, partly dismantled within a few generations of its completion, and the carved stones reused, erasing the narrative's original significance. In contrast, elements of the city's core layout persisted at least until the end of the Late Classic as a template, remembered and repeated, sometimes with modifications at Monte Alban and elsewhere, of how a city should be.
Vascular engineering on chip using differentiated stem cells

Organs-on-chip hold great promise for the creation of complex and realistic disease models while having the potential to refine, reduce and (partly) replace existing animal models (3R principle). Of all organs, vasculature is extremely well-suited to realize on-chip since it pervades the whole organism, is present in all other organs, its malfunctioning plays a role in many diseases and finally is ideally suited to approach with microfabrication and microfluidic technologies. In the VESCEL program we propose the development of innovative technologies enabling the use of differentiated human induced pluripotent stem cells (hiPSC) to engineer blood vessels on chip that constitute realistic disease models for thrombosis and neurodegenerative (ND) diseases. The use of differentiated hiPSC allows the realization of blood vessels based upon patient-specific material, without the need for biopsies, while development of integrated microsensors for small molecules (pH, O2, NO) offers the possibility of on-line monitoring. To optimize the hiPSC differentiation conditions we propose the use of a microdroplet platform, that combines high-throughput capability (up to 1000 cells/s) with control of single cell microenvironment. We will also develop a new flexible technology for real 3D vasculature realization using advanced 3D printing technologies. These four innovative technology developments will be integrated in two biomedical applications to study two important classes of diseases, thrombosis and neurodegenerative (ND) diseases. For thrombosis we focus on the study of parameters such as blood pressure and stenosis as well as effects of drugs on thrombus formation, while for ND diseases study we will use a blood brain barrier (BBB) model to investigate nanoparticle and peptide transport across the BBB for a form of Alzheimer’s disease, as well as leukocyte extravasation for multiple sclerosis (MS).
Geometrical approach to multi-phase RFID filtering in dense environments

In the upcoming ubiquitous computing environment, almost every object that needs to be identified will be attached to an radio frequency identification (RFID) tag. Omnipresent RFID tags lead to the concern that huge volumes of RFID data could easily overwhelm related networks and systems. However, for most applications, only a small subset of ID data is meaningful. It is critical to filter out the unnecessary ID data based on application requirements. A multi-phase RFID filtering technique that basically consists of pre-filtering and post-filtering phases is presented. To the best of our knowledge, most RFID filtering works have focused only on single-phase post-filtering. Our multi-phase filtering technique harmonises pre-filtering and post-filtering in order to raise the RFID system filtering efficiency. The main challenge for this type of multi-phase filtering technique is to derive air-protocol filters for pre-filtering from read filters for post-filtering that are guaranteed to cover the union of all read filters. The authors introduce geometrical algorithms for deriving air-protocol filters from read filters and verify their performance via simulations using analytical time models. The results show that our multi-phase filtering technique reduces the overall filtering time by almost 50% compared to the single-phase post-filtering technique.
First-principles studies on electronic structures of superatomic compounds [Co6Se8(PMe3)6][C60] in several cubic structures

Abstract Structural features, electronic structures, and optical properties of superatomic compounds [Co6Se8(PMe3)6][C60] with rock-salt, cesium chloride, and zinc-blende structures were investigated from first principles. Partial electronic density of states, highest occupied molecular orbital, and lowest unoccupied molecular orbital were given and used to discuss the detailed electronic structures. Dielectric function, refractive index, reflectivity, absorption coefficient, and energy loss functions under several pressures were calculated and used to investigate the optical properties. We found that Co6Se8(PMe3)6 transfers electrons and C60 receives electrons, making contributions to electron communications between the positive and negative counterparts on the basis of electrostatic interactions. The superatomic structures are made from assemblies of charge-rich and charge-poor molecular precursors. In the solid state, charge is transferred between the components, with a net reduction of C60 by less than one electron (0.75 electron approximately).
Values-Based Commissioning of Health and Social Care

Health and social care commissioning is a values-driven as well as evidence-driven enterprise. However, whereas there has been an expectation that the evidence-base of commissioning should be made fully explicit, the corresponding values-base has been left largely implicit. The book addresses this subject through a detailed discussion of values and values-based practice, illustrated with case examples, and by developing a critique of existing commissioning. This approach enables commissioners to identify and make explicit the often diverse values of all those involved, whether as commissioners, providers or users of services. It provides a skills base and other support processes for working with differences in values held by all those engaged in making commissioning decisions. This will be essential reading for doctors, both experienced and in training, commissioning managers, professional staff in NHS Foundation Trusts and the private sector and all 'at the sharp' end of practice.
Single molecule imaging-based design of hiv-1 vaccines

The HIV-1 vaccine research has re-emerged in the last few years due to the identification of antibodies that neutralize most HIV-1 circulating strains. A deeper understanding of the mechanistic mode of target recognition for these antibodies represents a big hope in the field. This project aims at understanding and characterizing polyclonal antibody responses to aid rational vaccine design via radically new technologies on light microscopy. The molecular mechanism of time-resolved HIV-1 fusion will be visualized and quantified on the surface of living cells by combining real-time single virus tracking, fluorescence fluctuation spectroscopy and 3D single molecule localization microscopy (SMLM) imaging. The implementation of a new technology that allows three-dimensional nanometre localization of single particles will allow us to multiplex single molecule experiments with functional readouts for single-virus HIV-1 fusion simultaneously. Here, I will systematically establish the mechanism of action of different families of neutralizing antibodies and how they disrupt the three-step HIV fusion reaction, conserved among different HIV tropism, recently discovered by our group. I will unveil the molecular insights on the precise Env-induced, time-resolved stoichiometry of CD4 and co-receptors (CCR5 or CXCR4) in the presence and absence of different combinations of bNAbs and study their impact on HIV transmission. FUSION will open new avenues to design putative drugs that target host-specific receptor and co-receptor oligomeric states to block HIV-1 fusion. This project systematically applies cutting-edge time-resolved imaging approaches as a gold standard to ascertain how different combinations of bNAbs perturb the HIV fusion mechanism in CD4+ T cells and macrophages. I will establish a world-class laboratory in HIV-1 and single molecule microscopy. I will decipher several key virus–host cell interactions at molecular level and contribute to rational vaccine and drug desig