SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Translation of a fluorescent myelin specific peripheral nerve tracer

Tracers that enable imaging of peripheral nerve structures have the potential to reduce the occurrence of perioperative peripheral nerve injury. Hence, through such a fluorescence-guided surgery technique morbidity and related follow up costs may be reduced and the quality of life of patients can be improved. The ability to visualize peripheral nerves also creates nerve-sparing opportunities for surgeons and opens up new commercial-avenues for companies involved in the surgical market. The aim of the MY NERVE ERC-PoC project is to strengthen the IP-position and aid the translation of a new nerve specific tracer. The most promising tracer derived from the ILLUMINATING NERVES ERC-StG, serves as the lead compound in this application. Systematic fine-tuning of this lead will help optimization of the structure-activity relation. Together with compatibility with clinical good manufacturing practice (GMP) production requirements this helps provide a solid basis for future commercialization. The applicant has a multidisciplinary track record in the chemical and (bio)medical field. By driving the clinical translation of new imaging tracers, his research group already has made significant contributions to the field of fluorescence guided surgery. Combined with legal support regarding IP-position, feedback from end-users (surgeons), and industrial partners with a global leading position in the surgical market, this background will ensure a translational approach. Ultimately, bridging the gap between synthetic chemical developments and the clinical demand for fluorescent tracers should help accomplish patient benefit.
Heteroaromatic biomolecules ultrafast spectroscopy in liquids

I propose to determine the complete ""structure-dynamics-function"" picture of the photoinduced processes happening in heteroaromatic bimolecules in solution under ultraviolet (UV) light exposure.
Whilst light induced processes are essential to life (vision and light harvesting processes such as photosynthesis are two prominent examples), they can also be extremely detrimental, as is the case for UV radiation damage of DNA. Nucleobases readily absorb UV light, accessing an electronically excited state and potentially triggering a structural rearrangement, leading to photolesions. Still, these “building blocks” of life present an inherent resistance (""photostability"") to these processes, compared to other classes of molecules. This property, far from being comprehensively understood, is believed to be linked with how efficiently these molecules release the excess energy of the photo-prepared electronically excited state through non-radiative relaxation pathways (conical intersections - CIs).
The location and topography of CIs can be extremely environment-dependent, particularly in a polar solvent like water: it is thus the interplay between solute and solvent that governs the dynamics and, thus, biological function of these molecules.
I propose to perform few-fs resolved deep ultraviolet (DUV) pump - extreme ultraviolet (XUV) probe time resolved photoelectron spectroscopy (TRPES) studies on heteroaromatic biomolecules in solution, with the goal of determining their solvent dependent structural changes (location of the relevant CIs) and the early stages (first tens of fs) of the related ultrafast relaxation pathways.
A deeper understanding of the relationship between the structure, dynamics and function of heteroaromatic biomolecules in solution under UV exposure could have multiple implications, from the more basic improvement of auxiliary protections against UV (e.g. better sunscreens) to more advanced materials- and bio- engineering based on nature mimicking.
Compliant actuation robotic platform for flexible endoscopy

Prof Alfred Cuschieri, the overall coordinator of ERC grant Colonic Disease Investigation by Robotic Hydro-colonoscopy (CODIR - grant agreement 268519) has recently submitted the mid-term scientific report on behalf of the two participating Universities (Dundee and Leeds), which highlights several novel IPR (intellectual property rights) issues resulting from the CODIR research, which are pertinent to robotic flexible endoscopy. One of these is based on the ‘active tether robot’ (ATR) idea for the provision of snake like locomotion; i.e., instead of the locomotive power for the active colonoscope being supplied to the back of the robot via a power cable, the design is turned on its head, and replaced by a motile segmented ‘active tether’, which is itself an endoscope, and which can operate in both a gas and aqueous environment. The platform is based on a Mini Compliant Joint (MCJ), with two degree of freedoms (DoFs) using Shape Memory Alloy (SMA) wires as actuators and torsional springs, a synergistic combination which increases the energy efficiency and mechanical bandwidth performance; and at the same time, reduces heat production and stress on the SMA wires. The MJCs actuates by current-induced contraction of SMA wires, two hollow articulating rings with 2 DoFs. As the rings have intersecting axes, the two torsional springs provide roll and pitch. Such a chain of active MCJs provides sinusoidal motor-less locomotion. In essence, CARPE is a generic modular system (capable of translation into any type of flexible endoscope in current clinical use) consisting of independent segments (much like a biomimetic vertebral column), mechanics and electronics. The big advance of CARPE, when used to construct a colonoscope over the current equivalent endoscope, is that once, the end of the CARPE colonoscope is inserted through the anus, it would travel by its intrinsic snake-like locomotion to the caecum.
Continuous random dynamical systems

We study a dynamical system generalizing continuous iterated function systems and stochastic differential equations disturbed by Poisson noise. The main results provide us with sufficient conditions for the existence and uniqueness of an invariant measure for the considered system. Since the dynamical system is defined on an arbitrary Banach space (possibly infinite dimensional), to prove the existence of an invariant measure and its stability we make use of the lower bound technique developed by Lasota and Yorke and extended recently to infinite-dimensional spaces by Szarek. Finally, it is shown that many systems appearing in models of cell division or gene expressions are exactly as those we study. Hence we obtain their stability as well.
Preliminary experimental evaluation of in-situ calibration methods for MEMS-based attitude sensors and Doppler sonars in underwater vehicle navigation

We report preliminary results of an in-water test-tank experimental evaluation of recently reported methods for the problem of in-situ calibration of the alignment rotation matrix between Doppler sonar velocity sensors and attitude sensors arising in the navigation of underwater vehicles. Unlike previous reports employing high-cost high-accuracy attitude sensors, including true-North-seeking gyrocompasses and high-precision accelerometers, we address the case of using attitude sensing with a low-cost Micro-electro-mechanical systems (MEMS) attitude and heading reference system. We report a comparative experimental evaluation of several recently reported calibration methods when employing low-cost MEMS attitude sensors. The methods are experimentally evaluated using data obtained with the Johns Hopkins University (JHU) remotely operated underwater vehicle in the JHU Hydrodynamic Test Facility. We report the preliminary results of comparative analysis of the performance of recently reported calibration methods and a most previously technique indicating satisfactory performance of the proposed methods for the problem of in-situ calibration of the alignment rotation matrix between Doppler sonar velocity sensors and low-cost MEMS-based attitude sensors.
Sostegno al mantenimento dell'attività imprenditoriale di K.P.PROJEKT Kajetan Piechowitz in una situazione di significativa diminuzione del fatturato dovuta alla COVID-19

Il progetto riguarda il sostegno al capitale circolante della società indicato al punto II.1 in caso di diminuzione significativa del fatturato (entrate derivanti dalle vendite) a causa della perturbazione dell'economia dovuta alla COVID-19. L'aiuto sarà utilizzato per mantenere le attività di un'impresa che si trova a seguito della pandemia di COVID-19 in una situazione di improvvisa carenza o mancanza di liquidità.
Abstract 19379: Red Blood Cell Washing Increases Kidney Injury in Cardiac Surgery Patients - The Role of Oxidised Lipids and Oxidative Stress

Introduction: Allogeneic red blood cell (RBC) transfusion in cardiac surgery patients increases the risk of pulmonary and renal morbidity. These associations are attributable to the ‘storage lesion’ - accumulation of metabolites in the RBC supernatant that includes pro-inflammatory lipids, cell-free hemoglobin and energy depletion. Hypothesis: Storage lesion components trigger different events that lead to organ injury. Reducing storage lesion by RBC washing or rejuvenation will reduce organ injury. Methods: Samples from 60 cardiac patients participating in a randomized controlled trial of RBC washing prior to transfusion versus standard care were analysed for inflammatory markers. In a complementary experiment, 4 groups of pigs received crystalloid infusion or 14-day old RBC that were left untreated, washed or rejuvenated (Rejuvesol, Citra Labs, IN). Inflammatory markers, free hemoglobin and iron were measured in blood. Leukocyte invasion was determined by immunohistochemistry. The results were verified and further analysed in an in vitro inflammatory model. Results: Transfusion of stored RBC (~22 days) into humans or pigs was associated with leukocyte activation, and attenuated by washing. That was attributed to oxidised lipids on transfused RBC derived microvesicles that activated monocytes and platelets, as revealed in depletion experiments. Unexpectedly, transfusion of washed RBC increased kidney injury, which correlated with higher free haemoglobin levels, oxidative stress (confirmed by HMOX-1 levels and protein carbonylation), and endothelial injury in washed RBC recipients. Oxidative stress triggered non-standard endothelial activation defined by expression of VLA5 and fibronectin retention. Either pathway was reduced when rejuvenated blood was transfused. Conclusion: Monocytes/platelets and endothelium are activated by oxidized lipids/MV and reactive free haem, respectively, and can be alleviated by RBC rejuvenation.
ACTIVE AGENT DELIVERY METHOD

A method for active agent delivery is provided which includes orchestrating focus groups and clinical studies and the distribution of educational materials and guidelines for counseling patients with regard to what the patients need to know and what the patients must do in order to both avoid adverse side effects while taking doses of active agent and to receive prescriptions for the doses.
A web-based decision support system to score forest understorey dynamics in response to management interventions in a changing world

Currently, forest management models focus predominantly on tree dynamics following interventions, and tend to ignore the plant species found below the trees on the forest floor (the understorey). This is a crucial oversight, as the understorey is the major component of biodiversity, provides vital ecosystem services, and can influence the overall functioning of the forest. As such, there is a need for a user-friendly tool to help predict key understorey plant performance indicators (e.g. biodiversity, share of species of conservation concern) across environmental contexts (e.g. macroclimate space, land-use history) and overstorey tree management (e.g. timber species choice, forest management systems, rotation times).
Based on the outcomes and insights from the ERC Consolidator Grant PASTFORWARD we propose to solve the lack of a user-friendly tool for understanding vital understorey dynamics by first creating a prototype web-based Decision Support System (UnderSCORE). Creating this tool will transfer the research output of the ERC PASTFORWARD project into a form that is of direct use for policy makers and forest managers. Such a tool is not currently available but clear legal and societal imperatives (e.g. Natura 2000, European Biodiversity Strategy) require its development, and provide the context for its adoption by potential users.
The first stage of this proof-of-concept project is to explore and confirm the understorey output data end users require, the input data they could typically provide, and the type of management interventions that they would typically contemplate. In the second stage, we will use this end user information, in conjunction with the distinctive scientific output of PASTFORWARD, to develop a prototype of the DSS. After the development of a first prototype, the DSS will be evaluated by a panel of end-users and then further optimized in order to guarantee maximal use and impact of UnderSCORE.
Frontiers in dust mineralogical composition and its effects upon climate

Soil dust aerosols are mixtures of different minerals, whose relative abundances, particle size distribution (PSD), shape, surface topography and mixing state influence their effect upon climate. However, Earth System Models typically assume that dust aerosols have a globally uniform composition, neglecting the known regional variations in the mineralogy of the sources. The goal of FRAGMENT is to understand and constrain the global mineralogical composition of dust along with its effects upon climate. The representation of the global dust mineralogy is hindered by our limited knowledge of the global soil mineral content and our incomplete understanding of the emitted dust PSD in terms of its constituent minerals that results from the fragmentation of soil aggregates during wind erosion. The emitted PSD affects the duration of particle transport and thus each mineral’s global distribution, along with its specific effect upon climate. Coincident observations of the emitted dust and soil PSD are scarce and do not characterize the mineralogy. In addition, the existing theoretical paradigms disagree fundamentally on multiple aspects. We will contribute new fundamental understanding of the size-resolved mineralogy of dust at emission and its relationship with the parent soil, based on an unprecedented ensemble of measurement campaigns that have been designed to thoroughly test our theoretical hypotheses. To improve knowledge of the global soil mineral content, we will evaluate and use available remote hyperspectral imaging, which is unprecedented in the context of dust modelling. Our new methods will anticipate the coming innovation of retrieving soil mineralogy through high-quality spaceborne hyperspectral measurements. Finally, we will generate integrated and quantitative knowledge of the role of dust mineralogy in dust-radiation, dust-chemistry and dust-cloud interactions based on modeling experiments constrained with our theoretical innovations and field measurements.
European Med-clusters Boosting Remunerative Agro-Wine Circular Economy

The EMBRACE project aims at testing a model and related toolkit for the establishment of 2 transnational meta-clusters working on the principles of the circular economy. The project, capitalizing model and instruments, will propose to Clusters, SMEs and Innovation stakeholders a set of instruments able to strongly introduce the principle and practices of the Circular Economy in two leading sectors of the Med Economy: Wine and Agro-food. The establishment of national Nodes will assure the provision of awareness and training actions addressed to both economic actors (SMEs and clusters) and Public Administration (Regions, provinces) with the final goal to introduce feasible circular economy practices into the two selected Sectors. The National Clusters aligned to circular economy principles will then be grouped into 2 Meta-Clusters (1 for the Wine sector and 1 for the Agro-Food sector) at MED level to assure cooperation and exchange of knowledge even through the EMBRACE platform. To strengthen the impact of the circular economy, viable business models for SMEs in the field of eco-innovation, large projects and related financing schemes/instruments will be developed during the piloting phase and then disseminated during the transferring phase. The tested models and instruments will be, then, disseminated to other areas and sectors, with the purpose of spreading the benefit of Circular Economy and promoting its sustainability through the adoption of ad hoc financial instruments.
Design and manufacture of sustainable materials for additive manufacturing technologies

There is an urgent need to reduce reliance on fossil fuel derived plastics. The vast majority of these polymers cannot be recycled due to additives within them and developing more sustainable material approaches is an imperative. This international and intersectoral RISE has the ambitious goal of world-class innovation in the design and additive manufacture (AM) of parts, components and devices using sustainable (bio)polymer materials. DeMANS will explore replacing traditional synthetic plastics with biomaterials in consumer products, simultaneously reducing our reliance on fossil fuels and developing new innovations and markets for bio-based products, contributing to the circular economy objectives of the European Green Deal. In line with the principle of ‘transforming knowledge into innovation’, DeMANS will define the key challenges that have to be met to move from laboratory to manufacturing by demonstrating the feasibility of the approach in the area of computer peripherals. DeMANS brings together complementary world-leading expertise from a network of 7 academic and industrial organisations from 3 European and 2 Southern hemisphere countries. The technical approach includes 1) identifying suitable biopolymers with properties matching industry standards, 2) identifying printing methods and 3) fabricating demonstrators and prototypes. The information will be synthesised to define a technological roadmap for sustainable approaches in AM. Knowledge sharing will be undertaken through a series of secondments, complemented by network-wide training events. DeMANS will enhance the quality of research & innovation in Europe, leading to increased competitiveness and growth. DeMANS will develop skills, offer exposure to new research environments and widen the career perspectives of the staff involved. Project results will be disseminated to relevant scientific, industry and governmental agencies to deliver impact in the largely unexplored field of sustainable material AM.
ASPEK PERPAJAKAN ATAS JASA KONSTRUKSI GUNA PEMENUHAN KEWAJIBAN PERPAJAKAN DI PT TIGA MUARA JAYA SURABAYA

Tax is major source of revenue for most, because the state of budget largely financed by taxes. Tax also has the greatest potential every year because of tax increases with the rate of population growth, economic, and political stability of a country.
This research was conducted at PT Tiga Muara Jaya Surabaya with the aim to analyze and determine aspects of income tax and VAT on construction services.
Method use in this research is descriptive qualitative approach. To analyze and determine aspects of income tax and VAT on construction services company use the precentage of completion method based on phyical progress using the accrual method. The result of study conclude that in the calculation of income tax article 4, paragraph 2 and VAT as well as for despoting and reporting of the company is correct.

Keyword: Tax, Aspect taxation of construction, Aspects of income tax, VAT
PERFORMANCE OF MULITPLE LINEAR REGRESSION AND NONLINEAR NEURAL NETWORKS AND FUZZY LOGIC TECHNIQUES IN MODELLING HOUSE PRICES

House price prediction continues to be important fo r government agencies insurance companies and real estate industry. This study investigates the perfor mance of house sales price models based on linear a nd non-linear approaches to study the effects of selec ted variables. Linear stepwise Multivariate Regress ion (MR) and nonlinear models of Neural Network (NN) and Adaptive Neuro-Fuzzy (ANFIS) are developed and compared. The GIS methods are used to integrate the data for the study area (Bathurst, Australia). While it was expected that the nonlinear methods wo uld be much better the analysis shows NN and ANFIS are only slightly better than MR suggesting q uestions about high R 2 often found in the literature. While structural data and macro-finance variables m ay contribute to higher R 2 performance comparison was the goal of this study and besides the Australi an data lacked structural elements. The results sho w that MR model could be improved. Also, the land value and location explained at best about 45% of the sale price variation. The analysis of price forecasts ( within the 10% range of the actual prediction) on average revealed that the non-linear models perform ed slightly better (29%) than the linear (26%). Th e inclusion of social data improves the MR prediction in most of the suburbs. The suburbs analysis shows the importance of socially based locations and also variance due to types of housing dominant. In general terms of R 2 , the NN model (0.45) performed only slightly bette r than ANFIS 0.39) and better than MR (0.37); but the linear MRsoc performed bett er (0.42). In suburb level, the NN model (7/15) performed better than ANFIS (3/15) but the linear M R (5/15) was better than ANFIS. The improved linear MR (6/15) performed nearly as well as the no n-linear NN. Linear methods appear to just as precise as the the more time consuming non linear methods in most cases for accounting for the differences and variation. However, when a much more in depth analysis is required non linear methods may prove to be more valuable. More research is nee ded in the area of house price modelling including more structural elements, modern buyer beliefs and the nature and type of risks noted in modern times.
A implantação do PEPE/IFRN e os impactos do IRA dos discentes

As questões da retenção e da evasão de estudantes no Ensino Superior no Brasil são recorrentes. Em 2016, o Instituto Federal de Educação, Ciência e Tecnologia do Rio Grande do Norte desenvolveu o Plano Estratégico de Permanência e Êxito (PEPE) para endereçar a questão da permanência e êxito no triênio 2016-2018. Esse trabalho faz uma avaliação, de abordagem quantitativa, com finalidade exploratória-descritiva, dos resultados desse plano, sob a perspectiva dos seus impactos no Índice de Rendimento Acadêmico (IRA) dos discentes. Com dados de desempenho de todos os alunos ingressantes desde 2014 e uso de estatística descritiva, a evolução do IRA dos alunos foi apreciada sob vários recortes e enfoques, como por campus, assistência estudantil e forma de ingresso. Os resultados sugerem poucas mudanças estruturais no coeficiente ao longo do plano. Apesar disso, houve achados importantes, tais como o impacto positivo da assistência estudantil no rendimento acadêmico dos alunos e rendimento superior de alunos ingressantes com cotas socioeconômicas.
DIVALENT NUCLEOBASE COMPOUNDS AND USES THEREFOR

Described herein are novel divalent nucleobases that each bind two nucleic acid strands, matched or mismatched when incorporated into a nucleic acid or nucleic acid analog backbone (a genetic recognition reagent, or genetic recognition reagent). In one embodiment, the genetic recognition reagent is a peptide nucleic acid (PNA) or gamma PNA (?PNA) oligomer. Uses of the divalent nucleobases and monomers and genetic recognition reagents containing the divalent nucleobases also are provided.