SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Rituximab Synergizes with Hydroxyurea or Vincristine in the Killing of Ramos Burkitt's Lymphoma B Cell Line

Rituximab is an effective immunotherapy for CD20-positive B-cell non-Hodgkin's lymphoma. However, some patients show resistance, particularly those suffering from more aggressive lymphoma types, such as Burkitt's lymphoma. Hence, Rituximab is commonly combined with several chemotherapeutic drugs. With a view to reduce the number of such drugs, we examined the effect of combining Rituximab individually with hydroxyurea, vincristine, or etoposide on the killing of Ramos Burkitt lymphoma cell line type I. Cell death was examined by using Annexin-V/propidium iodide staining. Combining Rituximab with hydroxyurea or vincristine resulted in a synergistic effect, whereas combining it with etoposide resulted in a subadditive effect. In single treatments, the percentage of cell death ranged from 23% (Rituximab) to 36% (hydroxyurea). Combining Rituximab with hydroxyurea or vincristine resulted in a synergistic effect (83% and 74% killing, respectively). In contrast, only a subadditive effect was noticed with etoposide (36%). We conclude that the synergistic effect of Rituximab with hydroxyurea or vincristine is worthy of further study, and that further in vitro screening of chemotherapeutics might identify chemo-immunotherapeutic combinations that are effective in vivo but less toxic than currently used regimens.
SYSTEM AND METHOD FOR TRANSLATING SOUND TO TACTILE

A Sound translating system configured to touch human skin comprising: a sound converter configured to process sound waves to a plurality of sound bands, wherein each sound band of the plurality of sound bands is represented by at least one electrical signal having specific electrical characteristics, wherein the sound converter is further configured to transmit the at least one electrical signal; at least one device comprising a plurality of actuators, wherein at least one actuator of the plurality of actuators is configured to convert the at least one electrical signal to mechanical vibration, wherein the mechanical vibration of each actuator stimulate tactile of one of a plurality of zones on the human skin, wherein the at least one actuator is dedicated to at least one predefined zone of the plurality of zones; and wherein, the predefined zone complies with a map used to allocate sound bands to zones on the human skin.
AC/DC ELECTRIC VOLTAGE CONVERTER

The invention concerns an AC/DC electric voltage converter comprising a bridge rectifier assembly (2) associated with a capacitor (1) and followed by a DC/DC converter (3). The bridge consists of controlled switches (6), in particular MOS transistors, and the capacitor is arranged upstream of the bridge, in parallel on the alternating current supply. The MOS transistors can be switched when the alternating current supply is at crossover. The invention is applicable to the supply of non-resistive loads.
Brain activation patterns of versive, hypermotor, and bilateral asymmetric tonic seizures

Patients who have seizure onset from different brain regions can produce seizures that appear clinically indistinguishable from one another. These clinically stereotypic manifestations reflect epileptic activation of specific networks. Several studies have shown that ictal perfusion single photon emission computed tomography (SPECT) can reveal propagated ictal activity. We hypothesize that the pattern of hyperperfusion may reflect neuronal networks that generated specific ictal symptomatology.All patients were identified who were injected with (99m)Tc-hexamethyl-propylene-amine-oxime (HMPAO) during versive seizures (n = 5), bilateral asymmetric tonic seizures (BATS; n = 5), and hypermotor seizures (n = 7) in the presurgical epilepsy evaluation between 2001 and 2005. The SPECT ictal–interictal difference image pairs of each subgroup were compared with image pairs of 14 controls using statistical parametric mapping (SPM 2) to identify regions of significant hyperperfusion. Hyperperfused regions with corrected cluster-level significance p < 0.05 were considered significant.We have identified a distinct ictal perfusion pattern in each subgroup. In versive seizure subgroup, prominent hyperperfusion was present in the frontal eye field opposite to the direction of head version. In addition, there was associated caudate and crossed cerebellar hyperperfusion. The BATS subgroup showed pronounced hyperperfusion supplementary sensorimotor area ipsilateral to the epileptogenic region, bilateral basal ganglia, and contralateral cerebellar hemisphere. The hypermotor seizure subgroup demonstrated two clusters of significant hyperperfusion: one involving bilateral frontomesial regions, cingulate gyri, and caudate nuclei, and another involving ipsilateral anteromesial temporal structures, frontoorbital region, insula, and basal ganglia.We have identified distinct hyperperfusion patterns for specific ictal symptomatology. Our findings provide further insight into understanding the anatomic basis of seizure semiology.
HYDRAULIC STEERING CIRCUIT AND HYDRAULIC CONTROL UNIT FOR THE CIRCUIT

In some steering systems, tractive forces occur in the hydraulic cylinder. If the cylinder is designed with a piston rod at one end only, the piston rod anticipates the steering motion in one steering direction. The result is uncontrolled steering characteristics, with all the dangers that this entails. The solution proposed to this problem consists in fitting, between the control valve (3) in the hydraulic control unit (1) and the space behind the piston head in the cylinder (2), a throttle (10) plus a by-pass line which negates the throttle function for hydraulic fluid passing towards the cylinder (2). The invention is intended for use in hydraulic steering-control units for low-speed vehicles.
Dynamic and mode characteristics for AlGaInAs/InP microdisk lasers subject to optical injection

Due to the merits of small size and low power consumption, microdisk lasers have been widely investigated as a potential light source for photonic integrated circuits. We investigate the dynamic and mode characteristics for a directional-emission microdisk laser subject to optical injection. At the free-running state, single-mode operation at 1540.16 nm with side-mode suppression ratio of 35 dB is realized for an 8- μ m -radius microdisk laser connected with a 2- μ m -width output waveguide at 7 mA. Under the injection locking state with the injection optical power of 2 mW, the 3-dB bandwidth of the small signal modulation response is enhanced from 3.4 to 13.7 GHz for the microdisk laser biased at 7 mA. Furthermore, the nonlinear states including four-wave mixing, period-one, and period-two oscillations are also observed and discussed for the microdisk laser subject to the optical injection with different wavelength detuning and optical power.
Migrant integration cockpits and dashboards

In ""MICADO: Migrant Integration Cockpits and Dashboards"", experts from public administration, migration research, and IT create an EU-wide applicable business intelligence solution in support of migrant integration, and pilot it in Antwerp, Bologna, Hamburg, and Madrid. The solution leverages existing and new data to design attractive digital services for three user groups: 1) public authorities for labour, health, education and housing, 2) engaged civic society, and 3) migrants and refugees. Added value is generated by a) delivery of customized information and services via user-centric interfaces (dashboards, cockpits); b) gathering of data consensually provided by migrants and helpers in their cockpits; c) creation of strategic operational knowledge through data analysis and visualisation; and d) direct communication and data exchange between involved stakeholders and institutions. Key technical innovations are chatbot language interfaces and automatic translation services for the migrants' cockpit, which facilitate access to integration services, communication with authorities, and data acquisition. Besides the technical solution, MICADO creates in local co-design sessions a universal service package, e.g. location and activity mapping, personal profiling, or matchmaking for mentors, jobs, education, etc. The workplan ensures extensive demand analysis and co-creation with user groups in the pilot locations. This identifies common challenges for the concept convergence phase, which produces the requirements for technical design and development. A resulting “universal” MICADO solution has monitored pilot implementations in the four cities, results of which are fed back into final iterations of technical development of the project partners. In the final project phase, co-development activities with local communities and institutions ensure uptake and local adaptation of the basic MICADO solution, and initiate context-specific modifications.
Using semantic workflows to disseminate best practices and accelerate discoveries in multi-omic data analysis

The goal of our work is to enable omics analysis to be easily contextualized and interpreted for development of clinical decision aids and integration with Electronic Health Records (EHRs). We are developing a framework where common omics analysis methods are easy to reuse, analytic results are reproducible, and validation is enforced by the system based on characteristics of the data at hand. Our approach uses semantic workflows to capture multi-step omic analysis methods and annotate them with constraints that express appropriate use for algorithms and types of data. This paper describes our initial work to use semantic workflows to disseminate best practices, ensure valid use of analytic methods, and enable reproducibility of omics analyses. Key elements of this framework are that it is knowledge-rich with regard to parameters and constraints that impact the analyses, proactive in the use of this knowledge to guide users to validate and correct their analyses and dynamic/adaptive as data sets evolve and change, all features that are critical for successful integration of omics analyses in a clinical setting.
Recycling of hard-to-treat, post-consumer textile wastes and conversion to insulation material for construction industry using a novel conversion technology.

This project, is relevent to call topic SC5-20-2014-1, is designed to scale up, develop and commercialise a manufacturing process for converting currently unusable post-consumer contaminated fibre waste from carpets and mattresses to a value added thermal and/or acoustic insulation for use in the building & construction industry. The project develops a novel insulation panel or roll with the effective design and development of a manufacturing system to collect and reprocess with novel anti-bacterial treatments to produce a competitive product that can be systemised at the commercial scale. 

A successful proof of principle trial and sample material has been produced. A detailed techno-economic feasibility study and experimental work is required for the improvement of the thermal performance and neutralisation of the bacterial contamination in the recycled fibre waste from carpets and mattresses. In addition, the production line requires machinery for cutting, tearing, cleaning, anti-bacterial contamination processing and packaging at the manufacturing level. EC support is the catalyst needed to drive this innovation into the market, while the exposure the scheme brings will help us to penetrate the market more quickly and exploit this technology in the UK, and will exploit within Europe and/or licence to others. The likely benefits to the partners, endusers and society are the access to valuable textile fibre, a significant reduction of carbon emissions and fostering business models that bring fibre waste close to zero and build a better understanding of the environmental impact of carpet waste fibre, as well as to mitigate the dependency of Europe on imported raw textiles.
Quantifying the effects of interacting nutrient cycles on terrestrial biosphere dynamics and their climate feedbacks  quincy

Nutrient availability plays a pivotal role in the response of terrestrial ecosystems to increasing atmospheric CO2 and climate change. The global role of nutrients is only poorly understood quantitatively, limiting the predictive understanding of terrestrial biosphere - climate feedbacks. The first generation of global nutrient-carbon cycle models shows strongly diverging estimates of the nutrient effect, resulting from lacking integration of ecosystem observations and fundamental uncertainties in the representation of governing processes. The objective of QUINCY is to clarify the role of the interacting terrestrial nitrogen and phosphorus cycles and their effects on terrestrial C allocation and residence times as well as terrestrial water fluxes. QUINCY will create a novel, predictive framework founded on the principle of resource optimisation, shifting the paradigm of terrestrial biosphere modelling towards an active biological control of matter flows. QUINCY’s main themes are (i) the effects of nutrient availability on plant photosynthesis and respiration, explicitly taking the energy requirement of nutrient acquisition into account, and (ii) the effects of vegetation-soil interactions, namely rhizosphere processes, on plant nutrient availability and soil C turnover. To corroborate these theoretical concepts, QUINCY will synthesise existing and ongoing ecosystem monitoring and manipulation studies. To specifically test emerging hypotheses on the effects of rhizosphere priming on soil C storage and plant nutrition - and to provide currently lacking data for soil-vegetation models - QUINCY will establish a tree mesocosm, elevated CO2 experiment. The novel model concepts will be consistently integrated to form a new general terrestrial biosphere model. For the first time, QUINCY will be able to address the multiway interactions of carbon, nitrogen, phosphorus and water cycles globally in a theoretically well-founded way commensurate with ecosystem observations.
Adhesive sheet

Provided is an adhesive sheet that shows excellent adhesive strength to both high-polar and low-polar adherends with reduced dependence on fossil-resource-based materials. The PSA sheet has an adhesive layer formed from a natural rubber-based PSA. At least 20% by weight of all repeat units forming the base polymer of the PSA are derived from an acrylic monomer. Biomass-derived carbons account forat least 50% of the total carbon content of the adhesive layer. The adhesive sheet has an adhesive strength of 18 N/20 mm or greater to a stainless steel plate (after left at 50 DEG C for 2 h) and anadhesive strength of 15 N/20 mm or greater to a polypropylene plate (after left at 50 DEG C for 2 h).
A Comparative Study of Soil Moisture Measurement Accuracy under Different Humidity Using TDR

[Objective]The research aimed to study the principle of TDR measurement of soil moisture,and find out the suitable range of the determination of soil moisture. [Method]With Poland TDR / MUX / mpts moisture analyzer,the volumetric water content of soil samples was measured under different humidity in Yichang. With the drying method and the ring knife method,the quality of the soil water content and dry density of the same soil samples were measured respectively,then transferred into a volumetric water content and compared with the accuracy of the results using TDR. [Result]For dry soil whose quality of the soil water content was 0- 5% and humid soil whose quality of the soil water content was above 22%,TDR measurement precision was low. Compared with the drying method,the absolute error was greater than 2%,and the relative error was greater than 10%. For the soil whose quality of the soil water content was 5%- 22%,TDR measurement precision was high. [Conclusion]At moist or semihumid area,the determination of soil volumetric water content with TDR method had a higher precision.
INNOVATIVE INVESTMENTS IN THE TOURIST ACCOMMODATION SECTOR

OBJECTIVES: COMPLETE THE POSITIONING OF THE STRUCTURE STARTED TWO YEARS AGO, TO ACHIEVE THE — INCREASE IN EXPECTED REVENUES. L — HOTEL MUST BE DEFINITIVELY PERCEIVED AS A LEVEL STRUCTURE IN THE PANORAMA OF HOTELS ON THE ADRIATIC COAST: DESIGN, WELLNESS AND ECO-SUSTAINABLE. THE INTERVENTIONS THAT WILL ALSO FOCUS ON THE ANNEX WANT TO ADAPT ALL THE STRUCTURE TO THE STANDARDS OF THE CENTRAL BODY OF THE — HOTEL, SO AS TO HAVE A WIDESPREAD LEVEL OF QUALITY. SPEECHES: WELLNESS AREA: WHIRLPOOL, SAUNA, TURKISH BATH, EMOTIONAL SHOWERS, RELAXATION AREA -RESTRUCTURING OF 3 ROOMS OF THE — HOTEL: RENOVATION OF THE FEW ROOMS THAT DO NOT MEET THE QUALITY STANDARDS RECENTLY INTRODUCED IN MUCH OF THE STRUCTURE -REALISATION OF 2 NEW ROOMS AND BATHROOM/STAIR ON THE FLOOR -FRANGISOLE: WE WILL INSTALL ON THE TERRACES OF THE FACADE OF THE — HOTEL DEI FRANGISOLE -DOMOTICA: EXTEND THE — HOME AUTOMATION SYSTEM ALREADY PRESENT TO THE REMAINING ROOMS AND
Humidity effect on hydration of CsLiB6O10 nonlinear optical crystal: X-ray diffraction study

• Cesium lithium borate crystals were kept under the relative humidity of 15–77%. • At RH 45% or lower, water molecules are incorporated into CLBO structure. • As a result symmetry reduces from I-42d to I-4 without the loss of crystal quality. Cesium lithium borate crystals (CLBO) grown from melt were kept under the relative humidity of 15–77%. At RH 45% or lower, water molecules are incorporated into CLBO structure resulting in symmetry reduction from I 4 ¯ 2 d to I 4 ¯ without the loss of crystal quality. At higher humidity, crystal degradation is caused by the presence of liquid water on its surface as a result of capillary condensation.
An interdisciplinary palliative rehabilitation intervention bolstering general self-efficacy to attenuate symptoms of depression in patients living with advanced cancer

Patients with advanced cancer, post-anticancer treatment, are living longer than 10-20 years ago. This emerging population of survivors has unique palliative and rehabilitation needs. A particular concern is depression, which can impair functioning, quality of life, and survival. The interdisciplinary Palliative Rehabilitation Program offers holistic palliative rehabilitation for this population using a self-efficacy framework. The current study examined the unique impact of three program factors that have been shown to improve depression: inflammation, exercise, and self-efficacy.Patients underwent a 2-month interdisciplinary intervention (up to six disciplines) and thorough pre-post assessments. Measures included serum C-reactive protein, 6-min walk test, General Self-efficacy Scale, and Hospital Anxiety and Depression Scale (depression subscale). Paired t tests analyzed pre-post changes in each variable, and a hierarchical linear regression analyzed the predictors' unique contributions of changes in depression in this quasi-experimental design.The sample included 80 patients (52.5% females), with stages 3/4 heterogeneous cancers. Results revealed that C-reactive protein (CRP) did not significantly change pre-post, from 7.39 (SD = 11.99) to 9.47 mg/L (SD = 16.41), p = 0.110, exercise significantly increased, from 372.55 (SD = 137.71) to 412.64 m (SD = 144.31), p < 0.001, self-efficacy significantly increased from 27.86 (SD = 6.16) to 31.23 units (SD = 5.77), p < 0.001, and depression scores significantly decreased, from 7.14 (SD = 3.91) to 5.95 units (SD = 3.51), p = 0.002. A hierarchical linear regression revealed that this model explained 15% of variance in changes in depression scores, p = 0.006. Change in self-efficacy accounted for 11% of change in depression scores (p < 0.001). Change in CRP and exercise did not make a significant contribution.A self-efficacy framework may be a helpful ingredient in interdisciplinary intervention to decrease depressive symptomatology.
Macroautophagy and necrotic neurodegeneration in ageing

Necrosis contributes critically in devastating human pathologies such as stroke, ischemia, and age-associated neurodegenerative disorders. Ageing increases susceptibility to neurodegeneration, in diverse species ranging from the lowly nematode Caenorhabditis elegans to humans. The mechanisms that govern necrotic neurodegeneration and its modulation by ageing are poorly understood. Autophagy has been implicated in necrosis and neurodegeneration, both with pro-survival and a pro-death roles. Autophagic flux declines with age, while induction of autophagy enhances longevity under conditions such as low insulin/IGF1 signalling and dietary restriction, which extend lifespan across diverse taxa. Our recent findings indicate that organelle-specific autophagy, including mitophagy, pexophagy and nucleophagy, is an important, evolutionarily conserved, determinant of longevity. We propose to dissect the molecular underpinnings of neuron vulnerability to necrosis during ageing, focusing on cargo-specific macroautophagy. To this end, we will implement a multifaceted approach that combines the power and versatility of C. elegans genetics with advanced, in vivo neuronal imaging and microfluidics technology. Our objectives are fourfold. First, we will monitor autophagic flux of organellar cargo, during neurodegeneration, under conditions that alter lifespan and identify mediators of organelle-specific autophagy in neurons. Second, we will conduct genome-wide screens for modifiers of age-inflicted neurodegeneration. Third, we will interrogate nematode models of human neurodegenerative disorders for organelle-specific autophagy and susceptibility to necrosis, upon manipulations that alter lifespan. Fourth, we will investigate the functional conservation of key mechanisms in mammalian models of neuronal necrosis. Together, these studies will deepen our understanding of age-related neurodegeneration and provide critical insights with broad relevance to human health and quality of life.
Advanced multistage sequential wastewater treatment technology

Enhancing of wastewater treatment technologies is a key goal of the EU to achieve sustainable and circular economy. Due to the required high investment and operational costs of current technologies, many industries find more economical to pay fines for direct discharges of polluted effluents than to treat them. Particularly, the heterogeneity and seasonality of the agro-food sector produce a broad variety of wastewater streams which claim for more efficient and customizable solutions to meet with increasingly stringent wastewater regulations.
Within this context, Ingeobras and Proycon have developed ANAERGY, a modulable wastewater treatment system that integrates for the first time: anaerobic, aerobic and advanced oxidation stages. The exclusive design of the anaerobic digester, including patented PUREMUST® technology, enable to reach high pollutants elimination rates (95-99%) and production of biogas (16 m3/m3). Also, its small size and flexibility allow reducing installation and operational costs, together with a tailored response to end-user´s requirements. Following their collaboration for 12 years, Ingeobras will manage technical upgrades, assembly, commercialization and installation, while Proycon will be in charge of manufacturing the digesters. 
The adoption of ANAERGY by industries lead to major economic savings by eliminating wastewater discharge fees and reducing energy costs (biogas ≈80% energy needs). The benefits that ANAERGY will bring to the market will make the proposed project profitable with a ROI of 6.6 over 4 years and a payback period by the 1st quarter of the second year. Likewise, by improving current technology, ANAERGY will decrease water pollution, increase water reusability and strengthen renewable energy share. Together, these actions generate social, environmental and economic benefits for all society, contributing to overall well-being, water and food security, and sustainable development.