SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Hepatic differentiation of human amniotic epithelial cells and <i>in vivo</i> therapeutic effect on animal model of cirrhosis

Human amniotic epithelial cells (hAECs) have been touted as an ideal stem cell candidate, being ethically neutral, immunologically naïve, plentiful in origin, and retaining plasticity in its fetal stage. We hypothesized that by applying natural physiological signals of the developing liver, hAECs can be coaxed into becoming functional immunopermissive hepatocyte-like cells. These cells would have tremendous potential for allogenic cellular transplantation in the treatment of chronic liver insufficiency.hAECs were obtained from term placentas and subjected to hepatic trans-differentiation. Hepatic differentiated cells were analyzed with immunophenotyping, electron microscopy, reverse transcription-polymerase chain reaction as well as characterized for hepatic metabolic function. In vivo efficacy was tested using intrasplenic transplantation into non-obese diabetic (NOD) Scid Gamma mice with thioacetamide-induced chronic liver failure and analyzed for engraftment and improvement in liver indices.With hepatic differentiation, hAECs assumed a hepatocytic polygonal morphology with upregulation of transcription factors responsible for liver specification. These hepatic differentiated-hAECs (HD-AECs) demonstrated bile canaliculi formation, secreted albumin, eliminated indo-cyanine green, uptook low-density lipoprotein, and inducible CYP3A4 and CYP2C9 enzymatic activities. Transplantation of HD-AECs and de novo hAECs in mice model of cirrhosis showed successful in vivo engraftment and differentiation into functional hepatocytes positive for human-specific albumin. HD-AEC cells that had undergone hepatic differentiation showed the greatest improvement in albumin function while preserving human leukocyte antigen-G expression postdifferentiation.hAECs were able to differentiate into functional hepatocyte-like cells both in vivo and in vitro. They showed therapeutic efficacy after transplantation in mice model of cirrhosis, offering an exciting source of cells for generation of functionally useful hepatocytes.
NUMERICAL STUDY OF THE LONGITUDINALLY ASYMMETRIC DISTRIBUTION OF SOLAR ENERGETIC PARTICLES IN THE HELIOSPHERE

Solar energetic particles (SEPs) affect the solar-terrestrial space environment and become a very important aspect in space weather research. In this work, we numerically investigate the transport processes of SEPs in three-dimensional interplanetary magnetic field, with an emphasis on the longitudinal distribution of SEPs in the heliosphere. We confirm our previous finding that there exists an east-west longitudinal asymmetry in the SEP intensities, i.e., with the same longitude separations between the solar source centers and the magnetic footpoint of the observer, the fluxes of SEP events originating from solar sources located on the eastern side of the nominal magnetic footpoint of the observer are systematically larger than those of the SEP events originating from sources located on the western side. We discuss the formation mechanism of this phenomenon, and conclude that the longitudinally asymmetric distribution of SEPs results from the east-west azimuthal asymmetry in the topology of the heliospheric magnetic field as well as the effects of perpendicular diffusion on the transport of SEPs in the heliosphere. Our results will be valuable to understanding Sun-Earth relations and useful for space weather forecasting.
Umbilical cord prolapse: A 10-year retrospective study in two civil hospitals, North Jordan

Umbilical cord prolapse (UCP) is an obstetric emergency. The objective of our study was to determine the frequency of cord prolapse, its aetiological factors and to evaluate fetal prognosis. This was a retrospective review of cord prolapse deliveries in the main two civil hospitals in North Jordan between 1995 and 2005, at Princess Badeea Hospital and at King Abdullah University Hospital (KAUH) in Irbid, North Jordan. There were 146 patients identified with UCP among a total of 64,192 consecutive births. The incidence of cord prolapse was one in 440 cases (146/64,192). It occurred mostly in women over 25 years, and significantly more in pre-term births, low birth weight babies, multigravida, and only a few were associated with induced cases. It was not associated with higher rates of perinatal mortality and this supports the benefit of clinical management of UCP by emergency (crash) delivery.
The Challenges Toward Implementation of Information and Communication Technology (ICT)in Secondary Schools in Ondo State, Nigeria

The study investigated the of Information and Communication Technology (ICT) in secondary schools in Ondo state. It sought to find out the level of access to ICT among secondary school teachers and students. Also the study investigated the level of utilization of ICT for instructional purposes and the attitude of teachers and students towards ICT utilization of ICT in secondary schools. The study adopted the descriptive survey design. The sample for the study consisted of 450 teachers randomly selected from two hundred and ninety six (296) secondary schools in the eighteen Local Government Areas of Ondo State. A combination of multistage, stratified and simple random sampling technique was used in selecting the sample. A questionnaire titled Challenges of information and communication technology for secondary schools teachers (CICTSST) was designed and validated. The data obtained were analyzed using frequency counts, percentages, mean and bar chart.The result of the findings showed that: ICT facilities are not available in schools. Majority of the teachers and students do not have access to ICT. There are significant factors affecting the utilization of ICT for instructional purposes. The study also revealed that teachers show positive attitude toward utilization of ICT in teaching and learning.
Modeling and characterization of vehicular density at scale

Future vehicular networks shall enable new classes of services and applications for car-to-car and car-to-roadside communication. The underlying vehicular mobility patterns significantly impact the operation and effectiveness of these services, and hence it is essential to model and characterize such patterns. In this paper, we examine the mobility of vehicles as a function of traffic density of more than 800 locations from six major metropolitan regions around the world. The traffic densities are generated from more than 25 million images and processed using background subtraction algorithm. The resulting vehicular density time series and distributions are then analyzed. It is found using the goodness-of-fit test that the vehicular density distribution follows heavy-tail distributions such as Log-gamma, Log-logistic, and Weibull in over 90% of these locations. Moreover, a heavy-tail gives rise to long-range dependence and self-similarity, which we studied by estimating the Hurst exponent (H). Our analysis based on seven different Hurst estimators signifies that the traffic patterns are stochastically self-similar (0.5 ≤ H ≤ 1.0). We believe this is an important finding, which will influence the design and deployment of the next generation vehicular network and also aid in the development of opportunistic communication services and applications for the vehicles. In addition, it shall provide a much needed input for the development of smart cities.
ID 383 – On the impact of stimulus intensity on vestibular evoked potentials (VestEPs)

Objective Recently published studies describe neural correlates of vestibular stimulation by means of evoked potentials. While some groups use loud click sounds or taps to the forehead we use passive body movements to study vestibular evoked potentials (VestEPs). Here, we investigated the impact of the acceleration intensity on the latency and amplitudes of the previously discovered VestEPs. Methods The EEG of eleven healthy subjects was recorded while they were seated in a racing chair mounted on a motion platform (hexapod). During the experiment the platform performed 216 translational movements using three different acceleration intensities. The EEG was analyzed in order to study the evoked potentials and the scalp topographies. Results We could replicate the characteristic potentials of vestibular stimulation as observed by our group in previous experiments. Additionally, we could show that the amplitudes of the VstEPs increased with higher accelerations. Conclusions Our data revealed that as in other sensory systems, e.g., the auditory, the stimulus intensity modulates the VestEPs amplitudes. Acknowledgements The work was supported by Deutsche Stiftung Neurologie, Graduate School for Systemic Neuroscience (GSN) and the German Federal Ministry of Education and Research (BMBF Grant code 01EO1401 ).
Preterm Birth Update

Preterm birth plagues modern society, with over three million deaths worldwide annually. When combined with low birth weight, preterm births are estimated to cost over one hundred million disability-adjusted life years. In the U.S., the low birth weight (newborn less than 2,500 gms) delivery rate in 2002 increased to 7.8 percent from 6.8 percent in 1985. This marks the highest rate in over thirty years. A large meta-analysis from 2009 analyzing abortion and preterm birth found an increased risk for preterm birth with an odds ratio of 1.35 (95 percent CI 1.20–1.52) for preterm demonstrating a 35 percent increase in the preterm birth rate in patients with only one abortion. The odds ratio for preterm birth for greater than two induced abortions was 1.72 (95 percent CI 1.45–2.04) demonstrating a 72 percent increase in the preterm birth rate and the important epidemiological principle of a dose-related effect: The more abortions one has prior to first pregnancy, the higher the risk for preterm birth. Finally, it is estimated that the concomitant expense due to prematurity from abortion may cost well over $1.2 billion per year in the U.S. in hospitalization (neonatal intensive care unit) costs alone.
Behavioral modeling of a monolithically integrated three-axis capacitive accelerometer based on the MetalMUMPs process

In this paper we present behavioral modeling of a monolithically integrated three-axis capacitive accelerometer using the standard MetalMUMPs process. The behavioral modeling is done in order to verify the design with respect to structural and electrostatic performance of the designed three-axis capacitive accelerometer. The proposed accelerometer is 3.2 mm × 3.5 mm in size, designed for sensing the acceleration of 25 g in three axes. The mechanical noise floor for in-plane ( x and y) and out-of-plane ( z) axes is 0.291, 0.316, and 2.84 µ g/√ (Hz), respectively. The total sense capacitance along the x, y, and z axes is 68.5 fF, 100 fF, and 6.19 pF, respectively. Sensitivity of 2.568 fF/ g, 4 fF/ g, and 0.252 pF/ g is obtained for in-plane ( x and y) and out-of-plane ( z) axes, respectively. The resonance frequency for the designed accelerometer is 800 and 2500 Hz for in-plane and out-of-plane axes, respectively. The results obtained by behavioral modeling are compared with the analytical results, which are approximately the same.
A description of the geological context, discrete traits, and linear morphometrics of the Middle Pleistocene hominin from Dali, Shaanxi Province, China

In 1978, a nearly complete hominin fossil cranium was recovered from loess deposits at the site of Dali in Shaanxi Province, northwestern China. It was subsequently briefly described in both English and Chinese publications. Here we present a comprehensive univariate and nonmetric description of the specimen and provide comparisons with key Middle Pleistocene Homo erectus and non-erectus hominins from Eurasia and Africa. In both respects we find affinities with Chinese H. erectus as well as African and European Middle Pleistocene hominins typically referred to as Homo heidelbergensis. Specifically, the Dali specimen possesses a low cranial height, relatively short and arched parietal bones, an angled occipital bone, and a nonprominent articular tubercle relative to the preglenoid surface all of which distinguish it from Afro/European Middle Pleistocene Homo and align it with Asian H. erectus. At the same time, it displays a more derived morphology of the supraorbital torus and supratoral sulcus and a thinner tympanic plate than H. erectus, a relatively long upper (lambda-inion) occipital plane with a clear separation of inion and opisthocranion, and an absolute and relative increase in brain size, all of which align it with African and European Middle Pleistocene Homo. Finally, traits such as the form of the frontal keel and the relatively short, broad midface align Dali specifically with other Chinese specimens from the Middle Pleistocene and Late Pleistocene, including H. erectus, and differentiate these from the Afro/European specimens of this time period.
Tracking and predicting neurodegeneration spreading across the brain connectome

Current knowledge of neurodegenerative diseases is limited by poor understanding of how they progress through the central nervous system (CNS). It has recently been hypothesized that clinical progression in these conditions involves the systematic spreading of protein misfolding along neuronal pathways. Protein aggregates would trigger misfolding of adjacent homologue proteins in newly-affected regions, and this would propagate in a “prion-like” fashion across anatomical connections. This proposal seeks to decipher the mechanisms of network-based neurodegeneration by understanding how the complex architecture of brain networks (the connectome) shapes the evolving pathology of neurodegenerative diseases, and to develop tools for monitoring disease progression from presymptomatic to later stages of the disease. 
NeuroTRACK will apply emerging network science tools to longitudinal, structural and functional brain connectivity 3T magnetic resonance imaging data from patients with frontotemporal lobar degeneration (FTLD) – a devastating, relentlessly progressive, young onset, neurodegenerative disorder. The study will involve both sporadic and familial cases, including presymptomatic gene mutation carriers. The proposal addresses the following fundamental questions: i) How and where does pathological protein propagation occur in the FTLD phenotypes? ii) Can pathological spreading be predicted from brain connectome fingerprinting? iii) How do different protein abnormalities translate into large-scale network degeneration? iv) How early are brain network changes detectable in the (even presymptomatic) course of the disease? 
The ground-breaking nature of the experiments planned in this proposal will pave the way to the development of novel tools for understanding the biological underpinnings of other CNS proteinopathies such as Alzheimer’s disease and Parkinson’s disease, and to identifying individualized, early interventions to modify disease progression.
Comparison of Metal-Ceramic and All-Ceramic Three-Unit Posterior Fixed Dental Prostheses: A 3-Year Randomized Clinical Trial

The aim of this randomized clinical study was to compare the 3-year clinical outcome of metal-ceramic fixed dental prostheses (MC-FDPs) and zirconia all-ceramic fixed dental prostheses (AC-FDPs) replacing a posterior tooth.A sample of 34 patients with a missing posterior tooth were randomly chosen to receive either a MC-FDP (n = 17) or an AC-FDP (n = 17). The FDPs were evaluated at baseline and yearly until 3 years after cementation. They were assessed using the California Dental Association assessment system. Periodontal parameters were measured at the abutment teeth, and the contralateral teeth served as control. The statistical unit was the FDP/patient.The survival rates for MC-FDPs and AC-FDPs were 100%. The success rate was 76% and 71% for MC-FDPs and AC-FDPs, respectively. Three technical complications were observed in the MC-FDP group and five in the AC-FDP group, all chipping fractures of the ceramic veneer. Furthermore, one biologic complication in the MC-FDP group (an apical lesion) was observed. No framework fractures occurred. All patients had optimal oral hygiene and showed no bleeding on periodontal probing at any of the recalls. Only minor changes in the periodontal parameters were observed during the 3 years of observation.Three-unit posterior MC-FDPs and AC-FDPs showed similar high survival rates and acceptable success rates after 3 years of function, and ceramic veneer chipping fracture was the most frequent complication for both types of restorations.
Enhancement of Chlorine Resistance in Carbon Nanotube Based Nanocomposite Reverse Osmosis Membranes

Aromatic polyamide membranes, which are prepared by interfacial polymerization of m-phenylene diamine (MPDA) in water solution and trimesoyl chloride (TMC) in organic solution, have been widely used as reverse osmosis (RO) membranes for desalination of seawater. However, it has been pointed out that polyamide RO membranes have weak resistance to chlorine, causing deteriorated separation performance. In this study, nanocomposite RO membranes containing multi-walled carbon nanotube (MWCNT) were developed to enhance the chlorine resistance of polyamide membranes. The resulting membranes were analyzed and tested to see the desalination performance. Nonionic surfactant (Triton-X-100) was used in the interfacial polymerization of organic/inorganic nanocomposite RO membranes to improve the dispersion of MWCNTs in the polymer matrix. Scanning electron microscopy (SEM) images and X-ray diffraction (XRD) spectra confirmed that MWCNTs were uniformly distributed in the polymer matrix. When 0.1–1 wt% of MWCNTs were ad...
Sustainable prefabricated glass façade with performance exceeding state-of-the-art glass façades

The proposed project is about an innovative breakthrough solution in glass façade design for more sustainable architecture and construction. Qbiss Air is the perfect match to European and global needs to improve energy efficiency, cut CO2 emissions, reduce Europe´s dependency on energy imports and provide healthy indoor living and working conditions. Using innovative, patented multi-chamber insulating core, Qbiss Air provides superior thermal insulation, Ucw≥0.3 kWh/m2K, which is at least two times better compared to state-of-the art glass facades. The revolution is fully transparent façade without the use of external sun shades which enables low energy building level 15-35 kWh/m2a without reducing internal comfort. Also, Qbiss Air increases daylighting vs. current glass facades, at the same thermal performance level. These benefits are unmatched by any other glass facades worldwide. Qbiss Air brings high-end overall building performance and benefits through the entire life cycle, including indoor comfort, economic value, environmental friendliness and high quality. For successful European and global market take-up, Qbiss Air needs final development, testing, certification, BIM integration and exploitation activities. Wide commercial potential for Qbiss Air is in new construction, renovation and segments with high-end performance and sustainable requirements. Consortium partners are key supply chain experts and will address all stakeholders – architects, facade consultants, installers, institutions and policy makers during the project and beyond. Qbiss Air innovation is appealing to potential clients, it will enable consortium partner´s turnover growth, create new jobs,
strengthen European competitiveness and innovativeness. Qbiss Air will move sustainable glass building construction to a higher level and enable faster achievement of nearly Zero Energy Buildings (nZEB), 2030 Climate and Energy Framework and Roadmap 2050 targets.
Towards unquenched holographic magnetic catalysis

We propose a string dual to the SU(Nc) N=4 SYM coupled to Nf massless fundamental flavors in an external magnetic field. The flavors are introduced by homogeneously smeared Nf D7-branes and the external magnetic field via a non-trivial Kalb-Ramond B-field. Our solution is perturbative in a parameter that counts the number of internal flavor loops. In the limit of vanishing B-field the background reduces to the supersymmetric one obtained in hep-th/0612118. We introduce an additional probe D7--brane and in the supersymmetric limit of vanishing B-field perform a holographic renormalization of its "on-shell" action. We consider also non-supersymmetric probes with fixed worldvolume gauge field corresponding to a magnetic field coupled only to the fundamental fields of the probe brane. We study the influence of the backreacted flavors on the effect of dynamical mass generation. Qualitatively the physical picture remains unchanged. In the next step we consider the case when the magnetic field couples to both the backreacted and the probe fundamental degrees of freedom. At sufficiently strong magnetic field the meson spectrum signals an instability of the probe D7-brane, which we interpret as reflecting an instability of the supergravity background.
Transmembrane 6 superfamily 1 (Tm6sf1) is a novel lysosomal transmembrane protein

The lysosome is a membrane-bound organelle involved in the turnover of various intracellular and extracellular macromolecules. These are degraded by acidic hydrolases in the lumen of lysosome. The lysosomal membrane is important not only in retaining the acidic hydrolases to protect cells against cytosolic proteolysis, but it also facilitates protein trafficking though organelle fusion. In this study, we report on a novel lysosomal membrane protein transmembrane 6 superfamily 1 (Tm6sf1). Expression of Tm6sf1-DsRed fusion proteins in HEK293A cells displayed punctate or ringlike vesicles, which colocalized with conventional lysosome markers including LAMP1/2, RAB7, and Rnf167. Using fluorescence time-lapse live cell imaging, we demonstrated the fusion of Tm6sf1 vesicles with lysosomes and the integration of Tm6sf1 into the lysosomal membrane. We also examined the expression of Tm6sf1 in mouse tissues and found immunopositive signals in major organs such as the cerebellum, kidney, and intestine. These data suggest that Tm6sf1 is a widely expressed lysosomal transmembrane protein and can be used as a novel marker of lysosome.