SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
TechTown

The digital economy is the 'single most important driver of innovation, competitiveness and growth' (EC,2015). TechTown will explore how small and medium sized cities can maximise the job creation potential of the digital economy. It will examine whether there is potential for spillover from stronger city level digital economies, examine how clusters can work at city level and look collaboratively at what cities can do to support businesses to access the digital skills and innovations they need in order to start, grow and compete.
&lt;b&gt;Sacha inchi as potential source of essential fatty acids and tocopherols: multivariate study of nut and shell&lt;/b&gt; - doi: 10.4025/actascitechnol.v35i4.19193

The present study investigated the fatty acid composition, tocopherols and nutritional factors in the nut and shell of Sacha inchi (Plukenetia volubilis) through multivariate data analysis. The nut showed a high lipid content (48.5%), while the shell showed a low content (1.2%), although both parts of the plant had similar fatty acid composition. Low contents of saturated fatty acids were found in both parts, indicating anti-atherogenic, anti-thrombogenic and hypercholesterolemic effects. The content of n-3 fatty acids (438.7 mg g -1 of total lipids) found in the nut corroborates with the literature, while the content found in shell (329.4 mg g -1 ) is not previously described. The total tocopherol content was higher than other oilseeds. The great amount of α-tocopherol present in the shell is highlighted since this is considered primarily responsible for the metabolic activity of vitamin E. Dietary Reference Intakes proved that both parts of Sacha inchi have a good nutritional supply. The use of multivariate analysis allowed nuts and shells to be distinguished and their constituents to be checked. The incorporation of Sacha inchi in the human diet is promising due to its intrinsic characteristics, as well as the use of the shell in food processing.
Neurocognitive Architectures and the Nonsymbolic Foundations of Fractions Understanding

Children and adults experience pervasive difficulties understanding symbolic fractions. These difficulties have led some to propose that components of the human neurocognitive architecture, especially systems like the approximate number system (ANS), are ill-suited for learning fraction concepts. However, recent research in developmental psychology and neuroscience has revealed neurocognitive architectures—a “ratio processing system” (RPS)—tuned to the holistic magnitudes of nonsymbolic ratios that may be ideally suited for grounding fraction learning. We review this evidence alongside our own recent behavioral and brain imaging work demonstrating that nonsymbolic ratio perception is related to understanding fractions. We argue that this nonsymbolic RPS supports symbolic fraction understanding, similar to how the ANS supports whole-number understanding. We then outline a number of open questions about the RPS and the ways in which it may be used to support fractions learning.
Refrigeration hose and hose coupling

A transmission component for a refrigeration or other fluid system having a hose constructed with a moisture barrier, a refrigerant barrier and a reinforcement layer, and a hose coupling. The hose coupling has a cap seal which fits over the end of the hose to seal it, and a shell assembly having an outer shell which fits over the hose end and cap seal, and a hose tube which enters the hose through the cap seal.
Relationship Between Visual Complexity and Aesthetics: Application to Beauty Prediction of Photos

Automatic evaluation of visual content by its aesthetic merit is becoming exceedingly important as the available volume of such content is expanding rapidly. Complexity is believed to be an important indicator of aesthetic assessment and widely used. However, psychological theories concerning complexity are only verified on limited situations, and the relationship between complexity and aesthetic experience on extensive scope of application is not yet clear. To this end, we designed an experiment to test human perception on the complexity of various photos. Then we propose a set of visual complexity features and show that the complexity level calculated from the proposed features have a near-monotonic relationship with human beings’ beauty expectation on thousands of photos. Further applications on beauty predication and quality assessment demonstrate the effectiveness of proposed method.
Leptin induces CYP1B1 expression in MCF-7 cells through ligand-independent activation of the ERα pathway

Leptin, a hormone with multiple biological actions, is produced predominantly by adipose tissue. Among its functions, leptin can stimulate tumour cell growth. Oestrogen receptor α (ERα), which plays an essential role in breast cancer development, can be transcriptionally activated in a ligand-independent manner. In this study, we investigated the effect of leptin on CYP1B1 expression and its mechanism in breast cancer cells. Leptin induced CYP1B1 protein, messenger RNA expression and promoter activity in ERα-positive MCF-7 cells but not in ERα-negative MDA-MB-231 cells. Additionally, leptin increased 4-hydroxyoestradiol in MCF-7 cells. Also, ERα knockdown by siRNA significantly blocked the induction of CYP1B1 expression by leptin, indicating that leptin induced CYP1B1 expression via an ERα-dependent mechanism. Transient transfection with CYP1B1 deletion promoter constructs revealed that the oestrogen response element (ERE) plays important role in the up-regulation of CYP1B1 by leptin. Furthermore, leptin stimulated phosphorylation of ERα at serine residues 118 and 167 and increased ERE-luciferase activity, indicating that leptin induced CYP1B1 expression by ERα activation. Finally, we found that leptin activated ERK and Akt signalling pathways, which are upstream kinases related to ERα phosphorylation induced by leptin. Taken together, our results indicate that leptin-induced CYP1B1 expression is mediated by ligand-independent activation of the ERα pathway as a result of the activation of ERK and Akt in MCF-7 cells.
Study of the Changes in Knowledge Industrial Center Layout Planning Types and Outside Space Composition Elements -Focusing on Guro-gu and Geumcheon-gu in semi-industrial district in Seoul-

Abstract According to the changes in society, the knowledge industrial center, which is a factory related to the manufacturing industry, is now including various programs, such as information and communication knowledge. This study defined the knowledge industrial center related law into three periods: deduct layout planning type and outside space composition elements by previous research; case analysis; and suggestions of the direction of layout planningand outside space plan. As a result of the analysis, first, before 1999, the layout of the building is made mainly witha car, but depending on the form of the site, it is configured as a centered, side layout. Second, in the case of distribution, the support facility on the lower part is integrated and the factory on the higher part is distributed, soit is partly integrated and the building is unified. Third, beginning with the activation of privately owned public spacein a semi-industrial district according to architecture regulations in 1999, the outside space is wider but the construction area is reduced, so the outside space composition has been changing in a similar manner to the planningmethods of business facilities, such as office buildings.
New strategies and tools for development of business environment in marginal rural areas

The TOOLS partnership was established in a previous project, financed by Ecos-Ouverture, which focused on the support of women entrepreneurship in the culinary heritage and tourism sector. The idea of TOOLS is to capitalize on the existing experience and expand the activities to new sectors and groups. It is planned to initiate and test new appropriate support methods especially for people with a lower ability to compete such as young people, women and unemployed persons by improving their opportunities for getting engaged in entrepreneurship. In parallel, the administrative capacity and knowledge of the public sector and the entrepreneurship supporting organisations will be enhanced.
Hiatuses in the late Pliocene–Pleistocene stratigraphy of the Ioffe calcareous contourite drift, western South Atlantic

Abstract The Ioffe Drift located in the Antarctic Bottom Water pathway from the Vema Channel to the Brazil Basin provides a suitable site to study past variations in bottom contour currents and their contribution to erosion and accumulation of deep-sea sediments. Our previous study of the reference core AI-2436 from the drift summit (Ivanova et al., 2016a) documented the stratigraphic sequence of the uppermost part of the sedimentary cover ranging from the recent through upper Pliocene, the reduced thickness and/or absence of biostratigraphic zones, and the occurrence of several hiatuses. Here, we provide the multi-proxy biostratigraphic, magnetic susceptibility (MS), color reflectance and X-ray fluorescence (XRF) data in the sediment cores AI-3318 from the summit and AI-3316 from the NE slope of the Ioffe Drift. The new data report numerous long- and short-term stratigraphic gaps over the last ~3 Ma. An interval of specific high-amplitude peaks representing abrupt changes in volume MS and XRF variability is identified from 2.51/2.59 to ~1.9 Ma which can likely serve as a regional stratigraphic benchmark in the future studies of deep-sea contourites. The correlation of three sediment records from the drift suggests that the most pronounced series of hiatuses, associated with enhanced AABW flow intensity occurred from 1.6 to ~0.81 Ma (i.e. roughly, during the Mid-Pleistocene Transition), and from 2.51/2.59 to ~1.9 Ma (i.e. covers the onset of the modern-type deep-water circulation in the South Atlantic (Turnau and Ledbetter (1989)). Comparison of the studied sediment records with DSDP Site 516 reveals reduced thickness of all recovered biostratigraphic zones and more often occurrence of hiatuses in the Ioffe Drift than on the Rio Grande Rise suggesting more vigorous contour currents in the former area.
Etica e politica nel dibattito sul realismo in Italia

Dobbiamo davvero preoccuparci dei concetti di realtà e verità? Come è proceduto, negli ultimi quindici anni, il dibattito italiano in merito? In questo articolo proveremo a dare risposta a queste e altre domande. Nel §1 introdurremo il dibattito e i suoi attori. Nel §2 ci concentreremo sulle connessioni tra i principali concetti coinvolti nella discussione cercando di proporne un’interpretazione che abbia l’obbiettivo di evidenziare eminentemente cosa è in gioco in termini etico-politici. Nel §3 cercheremo di dare un assaggio delle teorie proposte da ciascun autore per portare alla luce le reali motivazioni che muovono le differenti visioni. Infine, nel §4, trarremo delle conclusioni per quanto riguarda la validità e il valore del dibattito sottolineando cosa è comune alle varie posizioni e cercando di connettere il dibattito teorico con la situazione critica in cui attualmente versa il dibattito pubblico e con le problematiche etico-politiche che sono in gioco.
Light-Switchable proteins and adhesion micropatterns to illuminate the navigation machinery of neurons

Proper wiring and connectivity of the central and peripheral nervous system requires that during embryonic development neurons migrate and extend in the correct directions to connect to their targets. Defects in the neuronal navigation machinery lead to a variety of neurodevelopmental disorders such as Hirschsprung’s disease, Kallmann syndrome, ACC and has been associated with autism spectrum disorders and epilepsy. Neuronal navigation relies on a structure at the tips of neuronal extensions, termed the growth cone which is able to detect gradients of guidance molecules (chemotactants) secreted by cells at a distance. The chemotactant netrin, which binds multiple netrin receptors, can switch between attracting and repelling growth cones, a property which helps neurons change directionality upon reaching an intermediate target.	While it has been demonstrated that this is related to the complement of netrin receptors expressed by the neuron, it is unclear how different receptor combinations trigger opposing directional responses within the growth cone. It was recently shown that aberrant expression of netrin receptors in cells that don’t normally express it cause aberrant migration of neurons, which might explain some of the symptoms associated with neurodevelopmental disorders such as Mowat-Wilson syndrome. This proposal aims to understand at the molecular level how netrin can both attract and repel neuronal growth cones. This will be accomplished by mapping the interactome of both attractive and repulsive netrin-receptor complexes, and by mapping the spatial distribution and activity of proteins within actively steering growth cones, via high resolution microscopy, micropatterning and optogenetics to spatially modulate protein activities. This combinatorial approach will improve our understanding of neuronal guidance, associated disorders, and new technologies developed in this proposal might aid in the development of novel organ-on-chip technology.
Inverting linear combinations of identity and generalized Catalan matrices

We introduce the notion of the generalized Catalan matrix as a kind of lower triangular Toeplitz matrix whose nonzero elements involve the generalized Catalan numbers. Inverse of the linear combination of the Pascal matrix with the identity matrix is computed in Aggarwala and Lamoureux (2002) [1] . In this paper, continuing this idea, we invert various linear combinations of the generalized Catalan matrix with the identity matrix. A simple and efficient approach to invert the Pascal matrix plus one in terms of the Hadamard product of the Pascal matrix and appropriate lower triangular Toeplitz matrices is considered in Yang and Liu (2006) [14] . We derive representations for inverses of linear combinations of the generalized Catalan matrix and the identity matrix, in terms of the Hadamard product which includes the Generalized Catalan matrix and appropriate lower triangular Toeplitz matrix.
PAPERMAKING BELT HAVING REINFORCING PILES

A woven papermaking belt having a paper contacting top surface plane (24) and an opposed backside (26). The belt comprises a fabric (22) having yarns disposed, in part, in the top surface plane to form knuckles (36). The belt further comprises reinforcing piles (40) extending from a proximal end (42) to a distal end (44). The distal ends (44) of the reinforcing piles (40) are disposed between the top surface plane (24) of the papermaking belt and the backside (26) of the papermaking belt. The reinforcing piles (40) resist applied loads and may prevent deflection of the knuckles (36) during the papermaking process. The applied loads may either be normal to the belt, as occurs during imprinting, within the plane of the belt, which causes sleaziness of the belt, or both. The belt according to the present invention may have piles (40) with proximal ends (42) disposed at two or more different elevations, as well as distal ends (44), which are disposed at two or more elevations. This arrangement provides a belt which imprints different densities onto paper during papermaking, according to the ability of the piles (40) to resist compressive loads applied normal to the plane of the belt. In one alternative embodiment, the piles (40) may be disposed between the first and second layers of a multi-layer papermaking belt. The belt according to the present invention is particularly suitable for woven papermaking fabrics having long, unsupported knuckles.
The integration of symbolic and non-symbolic representations of exact quantity in preschool children

Preschoolers (n=62) completed tasks that tapped their knowledge of symbolic and non-symbolic exact quantities, their ability to translate among different representations of exact quantity (i.e., digits, number words, and non-symbolic quantities), and their non-symbolic, digit, and spoken number comparison skills (e.g., which is larger, 2 or 4?). As hypothesized, children's knowledge about non-symbolic exact quantities, spoken number words, and digits predicted their ability to map between symbolic and non-symbolic exact quantities. Further, their knowledge of the mappings between digits and non-symbolic quantities predicted symbolic number comparison (i.e., of spoken number words or written digits). Mappings between written digits and non-symbolic exact quantities developed later than the other mappings. These results support a model of early number knowledge in which integration across symbolic and non-symbolic representations of exact quantity underlies the development of children's number comparison skills.
Brain Tumor Therapy-Induced Changes in Normal-Appearing Brainstem Measured With Longitudinal Diffusion Tensor Imaging

To characterize therapy-induced changes in normal-appearing brainstems of childhood brain tumor patients by serial diffusion tensor imaging (DTI).We analyzed 109 DTI studies from 20 brain tumor patients, aged 4 to 23 years, with normal-appearing brainstems included in the treatment fields. Those with medulloblastomas, supratentorial primitive neuroectodermal tumors, and atypical teratoid rhabdoid tumors (n = 10) received postoperative craniospinal irradiation (23.4-39.6 Gy) and a cumulative dose of 55.8 Gy to the primary site, followed by four cycles of high-dose chemotherapy. Patients with high-grade gliomas (n = 10) received erlotinib during and after irradiation (54-59.4 Gy). Parametric maps of fractional anisotropy (FA) and apparent diffusion coefficient (ADC) were computed and spatially registered to three-dimensional radiation dose data. Volumes of interest included corticospinal tracts, medial lemnisci, and the pons. Serving as an age-related benchmark for comparison, 37 DTI studies from 20 healthy volunteers, aged 6 to 25 years, were included in the analysis.The median DTI follow-up time was 3.5 years (range, 1.6-5.0 years). The median mean dose to the pons was 56 Gy (range, 7-59 Gy). Three patterns were seen in longitudinal FA and apparent diffusion coefficient changes: (1) a stable or normal developing time trend, (2) initial deviation from normal with subsequent recovery, and (3) progressive deviation without evidence of complete recovery. The maximal decline in FA often occurred 1.5 to 3.5 years after the start of radiation therapy. A full recovery time trend could be observed within 4 years. Patients with incomplete recovery often had a larger decline in FA within the first year. Radiation dose alone did not predict long-term recovery patterns.Variations existed among individual patients after therapy in longitudinal evolution of brainstem white matter injury and recovery. Early response in brainstem anisotropy may serve as an indicator of the recovery time trend over 5 years after radiation therapy.
Hydrophobic monolithic silica with abundant pore as efficient adsorbent for organic contaminants removal

Hydrophobic (water CA, 155° ± 5°) monolithic silica (HMS) material with abundant pore was prepared via sol–gel method by using tetraethoxysilane as silicon source and trimethylchlorosilane as surface modification agent. High specific area and appropriate pores structure of the HMS material supply enough space for storing the absorbed molecules. The maximum adsorptive ability toward organic contaminants can reach 14 times the monolith’s weight. It is worth mentioning that saturated adsorption can be reached in a short time due to the interconnected macropores, which ensure that adsorbate diffuse in the bulk easily. In addition, it was verified that after an easy evaporation condensing treatment, the regenerated HMS material could retain its initial adsorption capacity. High adsorption capacities and good regeneration capability for organic-contaminants removal give the HMS material potential applications in wastewater treatment, chemical accident remediation, and environmental protection.
The “Megalithisation” of Iberia: A spatio-temporal model

In the last 20 years, the growing availability of radiometric data has led to profound changes in the archaeological study of cultural and social processes in European Late Prehistory. In this paper, we examine how the combined use of spatial analysis and Bayesian modelling can further contribute to an enhanced interpretation of the temporality of a major social phenomenon: the “megalithisation” process in Iberia. For the first time, it is possible to compare hypotheses regarding the start date, speed and direction of the spread of this major process for the whole of Iberia, and not just for selected regions or single sites. En los últimos 20 años la creciente disponibilidad de datos radiométricos ha provocado cambios profundos en el estudio arqueológico de los procesos sociales y culturales en la Prehistoria Reciente europea. Seleccionando un estudio de caso inscrito en la Iberia neolítica, concretamente la ‘megalitización’, examinamos cómo el uso conjunto del análisis espacial y el modelado bayesiano contribuye a una interpretación mejorada de la temporalidad de grandes fenómenos sociales. Por primera vez, es posible comparar hipótesis relativas a la fecha de inicio, velocidad y dirección de expansión de este gran proceso para toda Iberia, y no solo para regiones seleccionadas o sitios concretos. Au cours des 20 dernières années, la disponibilité croissante des données radiométriques a entraîné de profonds changements dans l’étude archéologique des processus culturels et sociaux de la Préhistoire tardive européenne. Dans cet article, nous examinons comment l’utilisation combinée de l’analyse spatiale et de la modélisation statistique bayésienne peut contribuer à une meilleure interprétation de la temporalité d’un phénomène social majeur: le processus de « mégalithisation » en Ibérie. Pour la première fois, il est possible de comparer les hypothèses concernant la date de début, la vitesse et la direction de la propagation de ce processus pour l’ensemble de l’Ibérie, pas seulement pour certaines régions ou des sites particuliers.