SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Innovative assay for micrornas analysis

MicroRNAs (miRNAs) are a class of newly discovered biomolecules implicated in numerous biological systems and in common human diseases (e.g. cancer, Alzheimer, osteoarthritis). It has been shown that MiRNAs are biomarkers with great diagnostic and prognostic value. MiRNAs can be the next generation targets for diagnostics and therapeutics and this is reflected in the miRNA analysis market which is forecasted to have a CAGR of 23.4% in the coming years.  Unfortunately, miRNAs are very difficult to detect and measure.  The methods we have today are complex, expensive and time consuming.  These limitations are restricting the use of miRNA in clinics and hospitals for diagnostic medicine.
LIVELMIA is an answer to these problems.  We has succeeded in developing a disruptive innovative method for high-throughput miRNAs analyses, that allows a general improvement in terms of cost, easy-of-use and accuracy.  We have cut down the time required by nearly a factor of 2, bringing the total analysis time down from 6 hours to 3 hours.  Furthermore LIVELMIA has a high specificity making it ideal in diagnostics to ensure quality readings in any condition.  LIVELMIA  is a chemical assay kit for quantification of miRNAs on various types of samples (blood, biopsies, cells) with applications in the field of health research  and diagnostics medicine. Our ultimate goal is helping biomedical researchers to improve miRNA studies and move miRNA analysis from laboratory to the clinic to bring profound benefits to public health.
Today we have a TRL6/7 prototype. We are gaining considerable interest from potential customers, dealers and stakeholders.  We have filed for a patent in 2018 and we are now submitting this Phase 1 proposal in order to study the feasibility and develop a business plan for LIVELMIA, where we intend to study the best segments for exploitation, our pricing strategy, costs, etc.
Assessing the Effects of the Sector Oversight Model on the Performance of Members of the Kwazulunatal Legislature

An assessment of the effects of the Sector Oversight Model on the performance of members of the KwaZulu-Natal Legislature was accomplished through data collected from a sample of sixty members of the legislature and full-time government officials. The objectives of the study were to evaluate the implementation of the Sector Oversight Model within KwaZuluNatal Legislature, to evaluate the impact of the Sector Oversight Model on management capabilities of members, to assess the effect of the Sector Oversight Model on provincial departments’ accountability, and to provide possible recommendations to the members of the KwaZulu-Natal Legislature and other relevant stakeholders. The literature review defined oversight and accountability and dealt with their inter relationship in relation to holding the executive arm of government accountable.
METHOD FOR COATING AN OPTOELECTRONIC CHIP-ON-BOARD MODULE AND OPTOELECTRONIC CHIP-ON-BOARD-MODULE

The invention relates to a method for coating an optoelectronic chip-on-board module (21) that comprises a flat support (2, 2') fitted with one or several optoelectronic components (4) and has a transparent, UV- and temperature-resistant coating (24) consisting of one or more silicones, to a corresponding optoelectronic chip-on-board module (21) and to a system comprising several optoelectronic chip-on-board modules (21). The method according to the invention comprises the following method steps: a) preheating the support to be coated (2, 2') to a first temperature, b) applying a dam, (22) which encloses a surface or partial surface to be coated of the support (2, 2') and is made of a first thermally curable, highly reactive silicone that cures at the first temperature, onto the preheated support (2, 2'), c) filling the surface or partial surface of the support (2, 2'), which is enclosed by the dam (22), with a liquid second silicone (23), and d) curing the second silicone (23).
Clinical significance of non-slip element balloon angioplasty for patients of coronary artery disease: A preliminary report

Recent advances in drug-eluting stent (DES) technology have succeeded in reducing restenosis. However, the use of DES is reportedly equivalent to bare metal stents in terms of long-term survival. In addition, stent materials represent foreign bodies, which if possible should not ideally be left within the patient. On these bases, an investigation was performed into the feasibility of a new approach, 'stentless' percutaneous coronary intervention (PCI), using a Lacrosse(®) non-slip element (NSE) balloon (Goodman Co., Ltd., Nagoya, Japan).In our 'stentless' approach, the NSE balloon is used for target lesion dilation in patients with low risk factors and simple target lesions. No stenting was performed once an optimal dilatation result was achieved, as evaluated by intravascular ultrasound (IVUS). In a total of 340 lesions in 304 patients, in whom the follow-up study was completed, the 'stentless' PCI by NSE balloon alone was achieved in 52 lesions (15%). Target lesion revascularization (TLR) was performed for 5 (9.6%) of the 52 'stentless' lesions. In the comparison between the 52 'stentless' lesions and the 31 DES lesions selected under the statistical matching of the patient profiles and baseline lesion characteristics, the TLR rate (9.6% vs 6.5%, p=0.616) and late lumen loss (0.52±0.26 mm vs 0.48±0.21 mm, p=0.347) were similar. In the 52 'stentless' lesions, IVUS parameters such as vessel area, minimal lumen area, and plaque area at both before and immediately after PCI were similar between the 5 TLR lesions and the 47 non TLR lesions.It is believed that the 'stentless' approach is applicable even in the DES era.
Sviluppo di un sistema autonomo di rilevamento dei guasti in linee di produzione automatizzate con metodi vibroacustici di medie dimensioni, utilizzando algoritmi di rete neurale intelligenti

Number_reference_aid_programma: SA.41471(2015/X) Finalità degli aiuti pubblici: Articolo 25 del regolamento (CE) n. 651/2014, del 17 giugno 2014, che dichiara talune categorie di aiuti compatibili con il mercato interno nell'applicazione degli articoli 107 e 108 del trattato È tutto qui. UE L 187/1 del 26.6.2014). L'obiettivo del progetto è quello di sviluppare un sistema autonomo di rilevamento dei guasti in linee di produzione automatizzate utilizzando metodi vibroacustici di medie dimensioni, utilizzando algoritmi di deep learning. Il sistema si inserisce nell'idea dell'Industria 4.0 consentendo il rilevamento remoto e automatico dei guasti dei dispositivi che generano processi vibroacustici non stazionari, in particolare i dispositivi ciclici, che sono elementi di linee di produzione di medie dimensioni, quali: azionamenti lineari, componenti pneumatici (valvole, ventose, ecc.), pompe, motori, bracci robotici. Il progetto prevede un lavoro di ricerca e sviluppo industriale sulla creazione di un sistema innovativo che possa essere utilizzato in impianti di piccole e medie dimensioni utilizzando linee di produzione di medie dimensioni, come indicazione automatica, intelligente e remota del guasto della linea, che impedirà costosi tempi di fermo o riparazioni. Il sistema sarà implementato sulla base di un'architettura composta da sensori, unità di controllo e un cluster computazionale. Il sensore convertirà l'onda meccanica in un insieme di valori digitali e invierà alla centralina. L'unità di controllo registrerà questi dati, elaborerà in immagini vibroacustiche e invierà una richiesta di identificazione dell'anomalia al cluster. Il processo di implementazione presuppone una fase di calibrazione in cui verrà insegnato il modello di rete implementato nel cluster.
RASAMSONIA TRANSFORMANTS

A method for carrying out recombination at a target locus in a Rasamsonia cell, which method comprises: - providing two or more nucleic acids which, when taken together, comprise: (a) sequences capable of homologous recombination with sequences flanking the target locus; (b) two or more site-specific recombination sites; (c) a sequence encoding a recombinase which recognizes the site-specific recombination sites; and (d) a sequence encoding a marker, wherein the two or more nucleic acids are capable of homologous recombination with each other so as to give rise to a single nucleic acid, and wherein at least two of the two or more nucleic acids each comprise a sequence encoding a non- functional portion of the marker; and - recombining in a Rasamsonia cell the said two or more nucleic acids with each other and with the sequences flanking the target locus so that a contiguous nucleic acid sequence encoding a functional marker and the sequence encoding the recombinase are inserted at the target locus, said marker-encoding and/or recombinase-encoding sequence being flanked by at least two site-specific recombination sites and the said site-specific recombination sites being flanked by the sequences capable of homologous recombination with sequences flanking the target locus, thereby to carry out recombination at a target locus in a Rasamsonia cell. The method may be used to generate marker free Rasamsonia cells.
Revisioning the ‘fiscal eu’: fair, sustainable, and coordinated tax and social policies

Plans for economic and monetary integration in the European Union call for fundamental changes in fiscal relations among EU member states and other countries. The 2012 Blueprint for the European Monetary Union (EMU) calls for deeper integration of fiscal policies at the level of domestic EU members, including establishing EU own-source revenues. The 2013 Social Dimension of the EMU emphasizes that this fiscal revisioning must also improve coordination of employment and social policies post-crisis to counteract declines in state revenues, evaluate fragmented policy initiatives during the crisis, and improve human well-being and capabilities ends in themselves and as preconditions to stable integration and sustainable growth.

This project will carry out in-depth comparative, interdisciplinary research using constitutional, legal, technical, institutional, qualitative, and quantitative methods to address four core issues:

* Options for expanding EU legislative competences or governance mechanisms for
   effective harmonization of member tax and social policies;
* Reform options for state-level coordination of fairer, more stable, and more sustainable      tax and social policy regimes;
 * Strategies for the increased effectiveness and harmonization of tax administration and
    compliance structures within the EU and non-EU areas; and
 * Recommendations for true own-source EU revenues.

This project is relevant to fundamental political and structural challenges that face the EU as it pursues deep fiscal integration. Fiscal policies encompass both revenue production and state spending priorities, and have tremendous impact on life choices, business planning, and economic development. Whether under conditions of stable growth or disruption, state revenues remain at the heart of state governance capacities; throughout, the well-being of the population as a whole remains at the heart of social and political stability and productivity.
A Sweet Vaccination – the Deadly Hershey’s Kiss

In Immunology courses, concepts such as primary and secondary immune response and the topic of vaccinations can be difficult to visualize for students. Described here is a short activity where students choose and snack on candy to simulate primary and secondary immune responses in the context of a vaccination. This short interactive activity is performed in the lecture course of Immunology, an upper-division Biology course that contains mostly Biology major juniors or seniors (class of 30–40). It is performed on the first day of class, and is consistently referred to as the semester progresses and more complex and detailed topics are introduced. It is utilized to help students understand and visualize the process of primary immune response, secondary immune response, immunological memory, and vaccinations.
Mazaro’S innovative transmissions for unrivalled electricity and fuel savings in transport

Road transport is in urgent need of driveline solutions that are TRULY sustainable, simpler and cheaper, to maintain competitiveness and create jobs. Here, MAZARO’s TRUFUS project outplays all current solutions with a large margin.
Transmission Technology International (2016 – p 18) states that for drastic fuel saving, the Continuously Variable Transmission (CVT) could be an alternative to Automatics and Manuals, because of its virtually infinite range of ratio adjustment, if only the conventional CVTs weren’t so inefficient. Now this is exactly the issue which TRUFUS has solved.
TRUFUS plans to launch the very first high-efficiency transmission that can keep a driveline on its lowest energy consumption curve continuously. Suitable for cars to heavy duty vehicles running on any kind of energy: electricity, CNG/LNG, fuel, hybrids…
Features: unrivalled energy and emission savings of 16-26% compared to the current drivelines; compact, light, silent, over 99% recyclable, low-cost, battery- and maintenance-free.
MAZARO, the sole company fully mastering this new technology, was a successful applicant to SME-Phase 1 and proved the uniqueness of its technology since then in an actual e-truck (26,2% further driving range at 80 km/h).
SME-2: vehicle manufacturers are impressed but expect proof on the road before ordering. So, SME-2 will focus on proving energy and emission reduction, endurance, performance and safety in a real bus and e-truck and prepare for production and market launch in 2019. Our manufacturing partner and a customer (EU vehicle manufacturer) decided to cooperate and invest in this SME-2 project.
Combined, the three companies involved in SME-2 expect to create 261 extra jobs in Europe by 2026.
Lead free automotive sli power

This project contributes to the call’s overall objective, which is to stimulate the competitiveness of eco-innovative SMEs
seeking to launch their products on world markets. This project introduces an eco-innovative product, a car-starting battery,
which contains no hazardous materials, extends battery life at least six times longer (in start-stop life) compared to lead-acid
batteries, and produces significant CO2 savings.

Olife has developed a new car battery that is a milestone in the evolution of the automotive industry. It is the first full
substitute for lead-acid batteries and offers many advantages, such as: superb performance, light weight, high range of
operating temperatures, ideally suited to start-stop systems, superior reliability and durability, resistance to extreme
vibration, starting ability up to 90% DOD (depth of discharge), lead and acid free, non-hazardous and eco-friendly.

The business innovation project aims to complete the development and to demonstrate industrial readiness and maturity for
primary market introduction (the new vehicle market), to build brand awareness, develop communication and dissemination
activities for both the primary market and the aftermarket. This objective will be accomplished via three key steps:
1) Testing, modification and finalisation of product development for OEM market
2) Communication and dissemination activities
3) Protection of intellectual property

The current battery market, due to LAB (lead-acid battery) technology limitations, offers a wide variety of batteries of different
capacities. Olife's offering (L2 and L5) successfully meets major market requirements.
• The L2 Olife battery is equivalent to a 55Ah LAB battery.
• The L5 Olife battery is equivalent to a 110Ah LAB battery.

Patent applications have been already submitted in the 120 countries. In Mexico and South Africa, a patent has already
been obtained. In other countries, patents are pending.
Nanopeptides and nanosaccharides for advanced and sustainable materials

Long-range research and innovation goal towards transformative biomaterials and technologies: The long-range goal of PEPSA-MATE is to develop and translate sustainable nanostructured functional materials, based on peptides and polysaccharides, using computer-based theoretical design approach and innovative fabrication technologies.PEPSA-MATE will generate a library of functional nanosaccharides and nanopeptides to be used as building blocks for the fabrication of advanced biomaterials.
Key Research and Innovation Goals: The objective of PEPSA-MATE is to turn biopolymers into sustainable products using innovative technologies. This will result in alternative biomaterial to conventional, non-degradable synthetic polymers and inorganic materials.
Scientific impact: Translation opportunities will be explored in three topic research areas; 1) Phytoglycogen nanoparticles to fabricate bioadhesives, bioplastics and drug carriers; 2) Ultrasonic fabrication of biofunctional nanopeptides; 3) Nanostructured saccharide microparticles as universal platform to deliver a wide range of therapeutic molecules.
Impact on early-stage researchers: PEPSA-MATE involves key participation of junior researchers providing strong support for the development of their careers.
Intersectoral dimension: PEPSA-MATE will develop intersectoral collaborations between a SME and academic partners to boost entrepreneurship creativity towards sustainable products and processes.
Interdisciplinary dimension: PEPSA-MATE will bring together interdisciplinary and complementary expertise in the field of nanomaterials science, polysaccharides and peptides chemistry, acoustic technologies, cell biology, biophysics, and computational modelling. International dimension: PEPSA-MATE will enable long-term, transformative research collaborations between research groups and SMEs settled in European Countries (Italy, Czech Rep., Germany and Spain) and in four non-EU Countries (Australia, Brazil, Cuba and South Africa).
Earthquake proofing of water treatment plants through seismic system risk analysis

In Japan, earthquake resistance improvement (earthquake proofing) of drinking water infrastructure is not as developed as for other types of infrastructure such as gas and electricity. To facilitate earthquake proofing, it is important for water utilities to encourage customers to better understand its importance and effectiveness. So that water consumers could instinctively understand the effectiveness of earthquake proofing, we applied the concept of ‘recovery time expectancy’ as an indicator of earthquake resistance of water treatment plants. In this study, we performed a recovery simulation of a medium-scale water treatment plant based on the system reliability theory, and then evaluated the effectiveness of earthquake proofing using recovery time expectancy as an indicator. The simulation was performed with five cases: the present condition of the facility and four hypothetical cases with different levels of earthquake proofing. As a result, the effectiveness of earthquake proofing was able to be expressed by a recovery curve showing the reduction of recovery time expectancy, and the priority became clear for seismically proofing each component of the plant according to the earthquake scale. Finally, the optimum capital investment was determined by comparing total costs (damage cost plus investment cost) of the five cases, which were computed according to recovery time expectancy after earthquake proofing.
Financial effect of bovine Johne's disease in beef cattle herds in Australia

To assess the financial effect of programs for controlling bovine Johne's disease (BJD) in beef herds.A spreadsheet simulation model of a self-replacing beef herd in south-eastern Australia selling 400-kg steers at 15 months old.The model calculated the monthly cash flow, and net present value (NPV) of cumulative cash flow, over 10 years. Four main control options were compared: (1) a base herd (no action to control the disease), (2) test and cull, and (3) partial and (4) total destocking. It was assumed that BJD was eradicated after 3 and 5 years with total and partial destocking, respectively, and not eradicated with a test and cull program. Scenarios were compared for both commercial and stud enterprises.If there was no discount on the sale price of cattle in commercial herds, deaths from BJD had to exceed 5% before the NPV of partial or total destocking was similar to taking no action to control the disease over a 10-year period. When cattle sales incurred a 10% discount, deaths had to exceed 1% before the destocking strategies would break even after 10 years.Control options for BJD should be carefully planned on an individual herd basis, as significant production and financial risks accompany destocking programs. Eradication will only be more profitable in the longer term, compared with living with the disease, when discounts on the sale of stock from infected herds are high. This can occur with the selling of store cattle or breeders. In stud herds, BJD will usually cause the total failure of the business.
TOPSIS Multi-Criteria Decision Modeling Approach for Biolubricant Selection for Two-Stroke Petrol Engines

Exhaust pollutants from two-stroke petrol engines are a problem for the environment. Biolubricants are a new generation of renewable and eco-friendly vegetable-based lubricants, which have attracted a lot of attention in recent years. In this paper, the applicability of the Technique for Order of Preference by Similarity to Ideal Solution (TOPSIS) method to support the process of building the scoring system for selecting an appropriate two-stroke lubricant has been analyzed. For this purpose, biolubricants (TMP-triesters) based on castor oil, palm oil, and waste cooking oil were produced and then utilized in a 200 cc two-stroke gasoline engine to investigate their effects on its performance and exhaust emissions. The results obtained from the use of the entropy technique in the TOPSIS algorithm showed that palm oil-based lubricant took up the greatest distance from the Negative Ideal Solution (NIS) and was selected as the most optimal lubricant for these types of engines.
Client-Controlled Cryptography-as-a-Service in the Cloud

Today, a serious concern about cloud computing is the protection of clients' data and computations against various attacks from outsiders as well as against the cloud provider. Moreover, cloud clients are rather limited in implementing, deploying and controlling their own security solutions in the cloud. The provider theoretically has access to stored keys in dormant images and deploying keys during run-time is infeasible because authenticating running VM instances is not possible.

In this paper, we present a security architecture that allows for establishing secure client-controlled Cryptography-as-a-Service (CaaS) in the cloud: Our CaaS enables clients to be in control of the provisioning and usage of their credentials and cryptographic primitives. They can securely provision keys or even implement their private virtual security module (e.g., vHSM or SmartCard). All clients' cryptographic operations run in a protected client-specific secure execution domain. This is achieved by modifying the Xen hypervisor and leveraging standard Trusted Computing technology. Moreover, our solution is legacy-compatible by installing a transparent cryptographic layer for the storage and network I/O of a VM. We reduced the privileged hypercalls necessary for administration by 79%. We evaluated the effectiveness and efficiency of our design which resulted in an acceptable performance overhead.