SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Role of Extracellular Calcium Control, Calcium Sensing, and Regulation of Calcium Regulating Hormones in Heart Failure

Calcium plays a pivotal role in excitation-contraction coupling of cardiomyocytes and many other cellular re- sponses observed in cardiovascular cells. Thus maintaining a healthy status requires very strict regulation of cytoplasmatic but also plasma ionized calcium concentration. Plasma ionized calcium is regulated by calcium sensing and the regulation of calcium uptake and secretion. Under conditions of heart failure, however, electrolyte deregulation occurs due to an ac- tivation of the sympathetic nervous system and the renin-angiotensin-aldosterone system because both systems are cou- pled calcium regulation and thereby also to the regulation of hormones controlling calcium homeostasis such as parathy- roid hormone, parathyroid hormone-related protein, and vitamin D that are activated in a calcium-dependent way. Of note, these hormones and receptors have also direct cardiac effects that modulate cardiac and renal function. Therefore, they play not only a role in end-stage heart failure but also in essential hypertension and reno-cardiovascular complications. In this review we summarize our current understanding about the role of calcium deregulation in heart failure and discuss the consequences from these observations. In conclusion, controlling plasma ionized calcium, plasma parathyroid hormone, and vitamin D status are pivotal in successful pharmacotreatment of patients with heart failure.
NEURAL STEM CELL COMPOSITIONS INCLUDING CHIMERIC POXVIRUSES FOR CANCER TREATMENT

Provided are methods and compositions for treating cancer with a combination of neural stem cells (NSCs) and a replication-competent oncolytic virus such as conditionally replication- competent chimeric orthopoxvirus (CF33). The cancer includes but is not limited to primary, recurrent, and metastatic brain cancer, breast cancer, head and neck cancer, bladder cancer, ovarian cancer, uterine cancer, prostate cancer, skin cancer, lung cancer, and colorectal cancer.
ATTACHMENT FOR HOLLOW FENCE POST

An attachment (1) for a hollow fence post, wherein it is formed by an elongated body exhibiting at least one insertion section (3) adapted for insertion into the cavity of the fence post (2). The insertion section (3) is fitted on its surface with at least one securing articulation for securing the insertion section (3) to prevent it from being pulled out of the cavity of the fence post (2).
Promoting RES Integration for Smart Mediterranean Islands

Mediterranean islands (Misl) are characterized by several energy criticalities in terms of high costs, security and management due to their high dependence on fossil fuels. PRISMI aims at tackling this key challenges by supporting the transition of Misl to an autonomous, cleaner, secure, low-carbon energy system – in line with the overall EU Energy Union package and EU2020 Strategy – through the development of an integrated trans-national approach to assess and exploit the renewable energy sources (RES)._x000D_
Such model will be developed through a studying project bringing together academia, public authorities and local communities of five target territories with a view to fully empower end-users in the take-up of project outputs._x000D_
Among these, the main ones constituting the key innovative value of the project are: _x000D_
- An integrated toolkit for assessing and mapping the local potential of RES and their exploitation in new energy systems._x000D_
- A Sustainable Energy Action Plan drafted for each case study area with recommendations and strategies for developing integrated RES._x000D_
- The establishment of a PRISMI Network of Stakeholders to support exchange of knowledge and best practices in RES integration in Misl._x000D_
These outputs will represent a reference framework supporting end-users in driving and intercepting economic initiatives aimed at increasing the penetration of RES in Misl energy mix – thus contributing to sustainable development and inclusive growth throughout the Programme area.
STABILIZED COLLOIDAL AND COLLOIDAL-LIKE SYSTEMS

The present invention generally relates to improved compositions comprising stabilized colloidal or colloidal-like phases (e.g., emulsions, aphrons) and methods of using those compositions. The compositions generally comprise an aqueous continuous phase, one or more viscosifiers, one or more surfactants, aphrons and one or more Aphron Stabilizers. The compositions of the present invention possess aphrons with significantly increased half-life and enhanced ability to seal permeable formations, and are capable of being used in high pressure applications.
Smart emerging electronics servicing dih

The market for organic & printed electronic products is growing at a high level (BUS$ 23-24 in 2014) with predicted annual growth rates of 20 % in all fields. Although the use of OLAE in products is still limited and only have been commercialized by large corporates, the number and type of products has grown significantly. These emerging markets are a huge opportunity for the EU industry. But EU small & mid-size companies have had only a limited access to technologies and often lack the capabilities needed to benefit from OLAE. These include the ability to fully understand the technological implications and the related business implications. They need support in the translation of the OLAE technologies into innovative products, assessing potential markets, finding investors, developing new business models and creating the right partnerships to optimally benefit from OLAE opportunities.
SMARTEES will be the Digital Innovation Hub dedicated to OLAE, an organized European innovation network that provides both access to competencies and business support for innovation adoption. SMARTEES will help the European industry to create a competitive advantage within the global economy by providing access to disruptive OLAE technologies and innovation support in a pragmatic, operative and efficient pan-European manner.
A 1-Stop-Shop will be set to establish a collaborative environment and to provide wider access to the technology at the same time as coordinating the bespoke services and efficiently and effectively linking them together. 20 Application Experiments will be conducted to explore the technology transfer into business, organization of cooperation, access to finance, services to be provided and act as showcases to raise awareness and activate potential users. The established eco-system will be harnessed by the consortium to propel the continuity of the initiative beyond SMARTEES. This will include the formulation of a comprehensive business plan as a strategic outcome.
Exploration of the soil biota associated to casuarinaceae trees from tropical ultramafic areas.

Pioneer plant species native to tropical ultramafic areas can be useful tools for the restoration of ultramafic soils degraded by nickel mining activities. 
Casuarinaceae trees are well known for its capacity to grow on nutrient-poor areas. This is possible thanks to multiple adaptations, including the formation of actinorhizal symbioses with nitrogen-fixing Frankia actinobacteria. Members of the genera Gymnostoma and Ceuthostoma (both from Casuarinaceae) colonise degraded ultramafic soils and promote the recovery of soil fertility. However, they produce high amounts of slow-degrading litter which (among other effects) reduce the colonisation by other plant species.
The project CASUABIOTA is intended to improve our knowledge of soil biota associated to Casuarinaceae from ultramafic areas of SE Asia. The project has two main objectives: 1) to advance our knowledge about Casuarinaceae-associated frankiae and its tolerance to nickel, and 2) to obtain insights about the composition of Casuarinaceae litter and the organisms involved in its degradation, with a special interest in earthworms and saprophytic fungi. 
To accomplish these objectives, a sampling campaign aimed at plants, litter, root nodules and earthworms will be performed in ultramafic areas from Sabah State (N of Borneo, Malaysia). Collected material will be subjected to different analyses (litter composition, earthworm barcoding, soil fungal metabarcoding) and two manipulative experiments on litter degradation will be performed on vermireactors and on mesocosms. 
Expected results include the identification of Ni tolerant Frankia strains, the assessment of litter effects on the composition of soil fungal and earthworm communities and the optimisation of a biological method to accelerate the degradation of Casuarinaceae litter.
This knowledge will ease the use of Casuarinaceae for the restoration of tropical Ni-mine spoils.
CENTRIFUGAL DYEING APPARATUS FOR TREATING WOUND FABRICS, IN PARTICULAR TEXTILE WEBS WITH LIQUIDS

The invention relates to a device for treating wound fabrics, in particular textile webs. The treatment comprises the bleaching, dyeing and washing of knitted and woven goods and nonwovens. These fabrics may contain cellulose, animal fibres, synthetic fibres and/or mixtures thereof. The fabrics would onto a perforated dyeing beam are treated with the liquids with the aid of centrifugal force such that a regular treatment is enabled at a consumption of water, chemicals and energy that is as low as possible. Disclosed is a centrifugal dyeing apparatus (100) having a closable container (1), a pump (14) for circulating the treatment liquor, and a driven dyeing beam (2) which is mounted rotatably in the container (1), is designed to receive a lap (4) of textile fabric and has a tube (3) with a perforation (37), characterized in that the provision is made of supporting beams (6), in that the supporting beams (6) radially support the lap (4), and in that the supporting beams (6) are connected to the dyeing beam (2).
A robotized system for encouraging grasshoppers to jump

This paper proposes a concept of a robotized system for encouraging grasshoppers to jump, since automatic control of the distance and direction between a target grasshopper and an encouragement action is required for analysis of jumping locomotion in grasshoppers. The proposed system has a simple mechanism with a rotational stage and an XY stage. This paper also develops a rotational stage, and investigates the performance of the rotational stage. In experiments, more than eighty percent trials in four of six individuals met all of the following three: (1) the rotational stage made a target grasshopper face a certain direction within a tolerance of ±1.5 degrees by using a visual servo control technique, (2) the grasshopper did not jump during the rotational stage worked, and (3) the rotational stage stopped automatically after the grasshopper stopped walking.
Polymeric diffusion matrix containing phenylephrine

There is disclosed a polymeric diffusion matrix for the sustained release of phenylephrine by transdermal delivery to a patient wherein the matrix comprises a polar plasticizer, polyvinylalcohol, polyvinylpyrrolidone, and a pharmaceutically effective amount of phenylephrine.
Phase behavior of dodecane–tridecane mixtures confined in SBA-15

Phase behavior of dodecane–tridecane (n-C12H26–C13H28, C12–C13) mixtures in bulk and confined in SBA-15 have been investigated using differential scanning calorimetry. Bulk C12–C13 system has a complicated behavior due to special rotator phase. It has been found that phase diagram of C12–C13/SBA-15 (3.8 nm) system is a straight line, C12–C13/SBA-15 (7.8 nm) a curve, and C12–C13/SBA-15 (8.9, and 17.2 nm) a loop line. The growth of the phase diagram shows size effect on phase behavior of C12–C13 mixtures. Moreover, in the range of 3.8–17.2 nm melting temperatures of pure C12 and mixtures at mole fractions x
 C13 = 0.1–0.5 have linear relation with inverse pore diameter, while C13 and mixtures at x
 C13 = 0.6–0.9 present curved lines. The confined mixtures show a similar melting behavior with pure C12, C13.
Remote-Activated delivery of therapeutic exosomes (radote) via an injectable peg hydrogel carrier

As a Marie Skłodowska-Curie Fellow, I will develop and demonstrate remote-activated delivery of biological therapeutics loaded into an injectable hydrogel, where delivery is triggered by applying near-infrared (NIR) light that safely and non-invasively penetrates deep into living tissues. The hydrogel carrier will be designed to deliver and stabilize cell-derived exosomes and microvesicles, together referred to as extracellular vesicles (EVs), which have recently gained attention for their ability to effectively deliver biological information and cargo directly to target cells. Developing sophisticated delivery systems for EVs will streamline their translation to clinical application, enabling the huge potential for this novel biological therapeutic to be fully realized. This system will be advantageous in simultaneously providing localized delivery, enhanced EV stability, and crucially, externally triggered release. This project will provide the first demonstration of localized and controlled delivery of EVs, with the added novelty of an externally NIR-triggered delivery system. By combining my expertise in designer hydrogel chemistry, the supervision of Prof. Molly Stevens at Imperial College London (ICL) who runs a world-class interdisciplinary biomaterials-focused group, and a secondment with The Technology Partnership (TTP) specializing in technology translation, this project is ideally situated to deliver the highest quality results.
What Is Statistical Mechanics?

Thermodynamics describes a large class of phenomena we observe in macroscopic systems. The aim of statistical mechanics is to account for this behaviour in terms of the dynamical laws governing the microscopic constituents of macroscopic systems and probabilistic assumptions. This
article provides a survey of the discussion about the foundation of statistical mechanics by introducing the basic approaches and discussing their merits as well as their problems. After a brief review of classical mechanics, which provides the background against which statistical mechanics is formulated, we discuss the two main theoretical approaches to statistical mechanics, one of which can be associated with Boltzmann and the other with Gibbs. We end with a discussion of remaining
issues and open questions.
Introduction of Participatory Conservation in Iran: Case Study of the Rural Communities’ Perspectives in Khojir National Park

Participatory conservation, as bottom-up management, is currently the most acceptable modelfor management of protected areas across the world. Social context is a central issue in the sustainablemanagement of conservation areas. It is also crucial to introducing participatory conservation. The newapproach therefore recognizes rural communities as key partners in biodiversity management and seeks theirparticipation in social development and biodiversity conservation. This paper examines the opinions andperceptions of local residents towards conservation, ecotourism, and Khojir National Park (KNP) in Iran. Aquestionnaire and informal interviews were conducted in five villages in or around the park. A comparativeanalysis of community participation and its barriers among the villagers were also employed. A model wasdeveloped to study attitudes of the local people and how they affect conservation and ecotourism development.The results revealed a moderate general knowledge about KNP and environmental issues, the lack of interactionbetween local people and government authorities, eagerness to participate in the activities of KNP, generalsupport for the conservation cause, and important differences among the villages. Furthermore, the majorityof respondents were classified as supportive of biodiversity conservation and neutral to ecotourism development,which may indicate a coexistent relationship. The research clearly identifies the need for devising strategiesand initiatives appropriate to specific local groups for optimizing their input in conservational issues. Theoptimization process of participatory conservation in Iran should be undertaken to create a congruent, sitespecificmodel with the best possible results based on world experiences.
Adequacy of depression treatment among college students in the United States

There is no published evidence on the adequacy of depression care among college students and how this varies by subpopulations and provider types. We estimated the prevalence of minimally adequate treatment among students with significant past-year depressive symptoms.Data were collected via a confidential online survey of a random sample of 8488 students from 15 colleges and universities in the 2009 Healthy Minds Study. Depressive symptoms were assessed by the Patient Health Questionnaire-2, adapted to a past-year time frame. Students with probable depression were coded as having received minimally adequate depression care based on the criteria from Wang and colleagues (2005).Minimally adequate treatment was received by only 22% of depressed students. The likelihood of minimally adequate treatment was similarly low for both psychiatric medication and psychotherapy. Minimally adequate care was lower for students prescribed medication by a primary care provider as compared to a psychiatrist (P<.01). Racial/ethnic minority students were less likely to receive depression care (P<.01).Adequacy of depression care is a significant problem in the college population. Solutions will likely require greater availability of psychiatry care, better coordination between specialty and primary care using collaborative care models, and increased efforts to retain students in psychotherapy.
BRAIDED STENT AND METHOD FOR ITS MANUFACTURE

A stent and method for making the stent are provided. The stent comprises regions of differing numbers of braided filaments to provide a stent with different dimensions and/or properties in different regions along the stent length. A preferred stent (10) comprises a first (11) and second plurality (12) of braided filaments each braided together. The second plurality of braided filaments is braided into the first plurality of braided filaments to form a region of different properties than the first. A preferred embodiment is a stent (100) having a narrower diameter along a more flexible region (110) and a broader diameter along a more rigid region (120). Also included is a method of constructing a braided stent in accordance with the above. The method comprises the steps of braiding a first plurality of filaments to form the flexible portion, combining a second plurality of filaments to the first plurality of filaments, and then braiding the second plurality of filaments with the first plurality of filaments to form the more rigid region from the combination of the first and second plurality of filaments, wherein the second plurality of filaments are braided only in the rigid region.
A mathematical modelling framework for understanding chemorepulsive signal transduction in Dictyostelium

Chemorepulsion is the process by which an organism or a cell moves in the direction of decreasing chemical concentration. While a few experimental studies have been performed, no mathematical models exist for this process. In this paper we have modelled gradient sensing, the first subprocess of chemorepulsion, in Dictyostelium discoideum-a well characterized model eukaryotic system. We take the first steps towards achieving a comprehensive mechanistic understanding of chemorepulsion in this system. We have used, as a basis, the biochemical network of the Keizer-Gunnink et al. (2007) to develop the mathematical modelling framework. This network describes the underlying pathways of chemorepellent gradient sensing in D. discoideum. Working within this modelling framework we address whether the postulated interactions of the pathways and species in this network can lead to a chemorepulsive response. We also analyse the possible role of additional regulatory effects (such as additional receptor regulation of enzymes in this network) and if this is necessary to achieve this behaviour. Thus we have investigated the receptor regulation of important enzymes and feedback effects in the network. This modelling framework generates important insights into and testable predictions regarding the role of key components and feedback loops in regulating chemorepulsive gradient sensing, and what factors might be important for generating a chemorepulsive response; it serves as a first step towards a comprehensive mechanistic understanding of this process.
NOVEL FUCOSIDASE INHIBITOR

The synthesis of the novel fucosidase inhibitor, 2,6-imino-2,6,7-trideoxy-D- glycero -D-­ gluco  heptitol, is disclosed.
Product lifecycle management (PLM) methodology for product tracking based on radio-frequency identification (RFID) technology

Existing product lifecycle management (PLM) software solutions today do not support product tracking. These solutions only support data exchange in company about products. Recent investigations indicate growing need to trace and manage data on products even when they leave the original production system, covering other product lifecycle stages such as exploitation, servicing, EoL (End of Life) warehousing, disassembly, recycling, and re-assembly. This paper describes radio-frequency identification (RFID)-based model, as part of a PLM solution, which allows updating of all critical product management information pertaining to changes in product status during its lifetime. The developed model allows application of RFID technology through dedicated software and hardware solution and software tools for decision making based on product information obtained by continuous tracing and updating, from the moment of delivery to end-user, to the moment of its life end. The model was verified on a circulation pump case study. The results gained in this study have shown that the proposed RFID-based PLM model is sufficiently generalized and with some adjustments could be used for various products.
Graphane/fully hydrogenated h-BN bilayer: Marvellous dihydrogen bonding and effective band structure engineering

In this work, density functional theory (DFT) computations with van der Waals (vdW) corrections were performed to investigate the dihydrogen bondings and their effects on the electronic band structures of graphane/fully hydrogenated h-BN (G/fHBN) bilayers. The type of dihydrogen bonding (C-H···H-B or C-H···H-N) defined the conformation and stability of G/fHBN bilayer, leads to significant band structure modifications of the nanosystems. Interestingly, the bilayer combined by C-H···H-B bilayers has an energy gap (∼1.2 eV) much lower than those of individual building blocks graphane and fHBN. Especially, changing the direction and strength of external electric field can effectively tune the band gap of G/fHBN bilayer, and correspondingly cause a semiconductor-metal transition. These findings offer new opportunities for developing electronic and opto-electronic devices based on G/fHBN bilayer, and inspire more endeavor in the usage of weak interactions for band structure engineering.