SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
<i>In Silico</i> Experimental Modeling of Cancer Treatment

In silico experimental modeling of cancer involves combining findings from biological literature with computer-based models of biological systems in order to conduct investigations of hypotheses entirely in the computer laboratory. In this paper, we discuss the use of in silico modeling as a precursor to traditional clinical and laboratory research, allowing researchers to refine their experimental programs with an aim to reducing costs and increasing research efficiency. We explain the methodology of in silico experimental trials before providing an example of in silico modeling from the biomathematical literature with a view to promoting more widespread use and understanding of this research strategy.
METHOD AND APPARATUS TO NORMALIZE QUANTITATIVE READOUTS IN SINGLE-CELL EXPERIMENTS

Provided herein are methods and systems for detection of nucleic acids for single cell samples. As part of the detection, a unique step of normalization of different single cell samples is included. One embodiment of the method includes selecting one or more target nucleic acid sequence of interest in an individual cell, where the target nucleic acid sequence is complementary to a nucleic acid in a cell.
Uma nova proposta didática para o ensino do português brasileiro como língua estrangeira (PLE) em âmbito universitário na Itália

Com o presente artigo, busca-se apresentar uma nova proposta didática para o ensino do português brasileiro como língua estrangeira (PLE), expondo a metodologia aplicada para a realização da obra “Aprendendo o português brasileiro”, publicada em novembro de 2022, na Itália, a qual decorre da experiência da autora no ensino da língua em âmbito universitário, entre 2019 e 2022, na Universidade Sapienza, na Universidade de Teramo e na Escola de Mediação Linguística da Fundação San Pellegrino. Propõe-se um ensino baseado em situações reais e nos diferentes contextos de interação que o aprendiz pode vivenciar no dia a dia com o uso da língua, adotando-se como método de ensino também a análise contrastiva que possibilita ao aluno a aplicação da estratégia dedutiva.
Radial compressor with a diffuser for use in a turbocharger

A radial compressor, in particular for a turbo-charger, has a spiral housing and a diffuser. The diffuser is constructed such that a low-pressure region in the area of the transition between the spiral housing and the tongue is at least reduced.
The effects of aging in the control of eye movements and its relation to perceptual and motor decisions

Aging involves a series of changes affecting both our cognitive abilities and our motor performance. As any other action, the control we exert over our eye movements changes due to aging. For example, the older we are, the less accurately we pursue moving targets. Even though vision -assisted by eye movements- is the main sensory source of information we use to make most of our decisions (and especially those related to actions), the effect that changes in the oculomotor behavior have on our perceptual and motor decisions remains unknown. The aim of DECEYEDE is to define how oculomotor control evolves with age, and how these changes accompany changes in perceptual and motor decisions. To do so, we will first assess how adults of different ages look at targets in dynamic scenarios about which they have to make a decision. Several parameters such as saccade latencies, number of saccades or pursuit gain will be evaluated, and a relation between such parameters and the performance in perceptual and motor decisions tasks will be established. Second, we will apply parameter based-feedback to explore if we can train eye movements in order to improve performance. We will do so by providing feedback to participants about specific parameters of their oculomotor performance. Such feedback will try to steer eye movements towards parameters similar to those that lead to better perceptual and motor performance. DECEYEDE will advance knowledge on the effects of aging on how we sample visual information from the world around us, and will allow further understanding of the mechanisms behind the decline in perceptual and motor tasks with aging. Furthermore, a successful method to train eye movements based on parameter feedback would represent a breakthrough that would set foundational principles for new ways of sensorimotor learning that will likely impact on the industry developing serious games or training and rehabilitation programs.
Fourier Transform Infrared spectroscopy discloses different types of cell death in flow cytometrically sorted cells

Fourier Transform Infrared (FTIR) spectroscopy is a label free methodology showing promise in characterizing different types of cell death. Cervical adenocarcinoma (HeLa) and African monkey kidney (Vero) cells were treated with a necrosis inducer (methanol), novel apoptotic inducers (diphenylphosphino gold (I) complexes) and positive control, auranofin. Following treatment, cells stained with annexin-V and propidium iodide were sorted using a Fluorescence Activated Cell Sorter (FACS Aria) to obtain populations consisting of either viable, necrotic or apoptotic cells. Transmission Electron Microscopy confirmed successful sorting of all three populations. Four bands were identified which could discriminate between viable and necrotic cells namely 989 cm(-1), 2852 cm(-1), 2875 cm(-1) and 2923 cm(-1). In HeLa cells viable and induced apoptosis could be distinguished by 1294 cm(-1), while four bands were different in Vero cells namely; 1626 cm(-1), 1741 cm(-1), 2852 cm(-1) 2923 cm(-1). Principal Component Analysis showed separation between the different types of cell death and the loadings plots indicated an increase in an additional band at 1623 cm(-1) in dead cells. FTIR spectroscopy can be developed into an invaluable tool for the assessment of specific types of chemically induced cell death with notably different molecular signatures depending on whether the cells are cancerous and mechanism of cell death.
É POSSÍVEL O PROFESSAR ANÔNIMO? A VOZ AINDA DISSONANTE DE VIOLETA LEME

RESUMO O presente artigo visa apresentar uma discussão acerca dos contornos da palavra e da ação docentes em nossa sociedade. A reflexão é conduzida e inspirada pela narrativa de uma professora que, no início do século XX, decide tornar pública a sua experiência nas escolas do estado de São Paulo e transformá-la em um livro intitulado O calvário de uma professora (1928). Orientados por aportes da filosofia e da psicanálise na educação, os argumentos aqui desenvolvidos buscam examinar as implicações, ao ofício docente e ao professar, de uma educação compreendida como atividade fabricadora, regida por uma lógica tecnocrática, que rechaça a fragilidade e a imponderabilidade próprias à ação educativa.
SYSTEM AND METHOD FOR ELECTRONIC ASSIGNMENT OF ISSUES BASED ON MEASURED AND/OR FORECASTED CAPACITY OF HUMAN RESOURCES

A method for capacity forecasting may include determining expected issues by averaging a number of each issue type submitted per a time period to predict a quantity of each issue type that will be submitted in a next time period, determining an expected issue capacity need in the future for each skill level of the assignees based on the expected issues, and determining assignee demand by averaging a number of each issue type assigned to each assignee per the time period. For each assignee, the method may include determining an expected assignee demand by identifying a number of the expected issues on which each assignee will be expected to work based on the expected issues and the assignee demand, determining an expected individual capacity based on the expected assignee demand, and determining assignments of issues to the assignee based on the expected issue capacity and the expected individual capacity.
Intervene earlier to help women maintain control of reproductive decision making

To the Editor: We read with great interest the recent article by Upadhyay et al. [1] on factors associated with discontinuation of contraceptive use and unintended pregnancy within 1 year after abortion. While we agree that proximal factors likely contribute to a woman's inability to take charge of her reproductive life, we also submit that a woman's reproductive trajectory may be influenced by events much earlier in the life course. Our previous work has shown that age at sexual debut less than 15 years has been associated with gaps in contraceptive use throughout reproductive life [2] and increased risk of multiple unintended pregnancies [3]. Further, reported nonconsensual sexual debut less than age 15 years increased the odds of multiple unintended pregnancies dramatically. Indeed, those who report younger age at sexual debut are more likely to report a nonautonomous reason (such as peer pressure or desire to please a partner) for engaging in their first intercourse. This may lead to reduced self-efficacy ultimately influencing a woman's ability to protect herself from sexual risks, including unintended pregnancy [4]. The finding reported by Upadhyay et al. that women with a history of abortion were more likely than women without such history to have selected their contraceptive method due to the provider interaction may also influence contraceptive discontinuation. This may represent ambivalence toward contraception use in general, reduced information about contraceptive options prior to counseling or a desire to avoid provider conflict. Ambivalence or a desire to avoid conflict may be representative of a larger inability to make autonomous reproductive decisions. Primary prevention efforts to empower girls to make informed and autonomous decisions about sexual debut as well as cognitive–behavioral interventions aimed at increasing sexually assertive beliefs, behaviors and practices for women of all ages may be justified.
LONG-TERM OUTCOME OF EPIRETINAL MEMBRANE SURGERY IN YOUNG CHILDREN

To describe the clinical characteristics of epiretinal membranes (ERMs) secondary to nonprogressive diseases in very young children and to assess their surgical outcome.Retrospective interventional case series study of 13 pediatric patients (aged less than 12 years) operated on for ERM more than a 6-year period. Visual acuity measurement, ophthalmic examination, and optical coherence tomography imaging were assessed preoperatively and postoperatively.Mean age was 6.5 years (3-12 years). Mean follow-up duration was of 28.5 months (12-69 months). Among the 13 patients, there were 7 cases of idiopathic ERM, 4 cases of combined hamartoma of the retina and retinal pigment epithelium, and 2 cases of posttraumatic ERM. The diagnosis of ERM was fortuitous in 10 cases (77%). Twelve children (92%) experienced a functional improvement. All patients received adjuvant treatment of amblyopia. Best-corrected visual acuity improved significantly after surgery from 20/160 to 20/40 (P = 0.001).Even in very young children, surgery resulted in a significant long-term improvement. Children screening was essential for diagnosis and treatment in most cases.
Enhancing and strengthening projects for the ecological restoration of habitats in the Alps

RestHAlp+ will continue the collection and analysis of statistics on already equipped sites and new case studies, to which will be added the assessment of the impact of ecological remediation on ecosystem services and the mitigation effect of wetlands on climate change.
The restoration of habitats will take place respecting the sensitivity of the territory and through the use of local seeds and the use of specific mechanizations.
The effort to curb the invasion of some exotic species that threaten the biodiversity of protected areas will continue with the monitoring of their spread and the study of eco-sustainable methods of control.
In parallel with these actions, it will be an opportunity to enhance the results of RestHAlp among the population, the operators of the supply chain and the scientific environment, through activities of civic science, dissemination, technical training and sharing of experiences.
Clinical, radiological and pathomorphological changes in the tissues of the shoulder and elbow joints in patients with rheumatoid arthritis

Clinical and morphological picture of rheumatoid arthritis (RA) is characterized by a complex combination of inflammatory, distrophic, destructive, reparative, and sclerosing processes in the tissues of the joints. However structural changes in the tissues of the upper limb joints (shoulder and elbow) in cases of RA understudied. Objective: to set clinical, radiological and pathomorphological features of the tissue in the shoulder and elbow joints in patients with RA. Methods: we investigated the tissues of the shoulder or elbow joints in six patients with RA who underwent total joints replacement with the removal of fragments of the articular ends of bones and the joint capsule using clinical, radiologic and pathomorphologic analysis. Sections were stained with hematoxylin and eosin. It was found that complex pathological changes in the tissues of the articular ends and of the joint capsule are based on the functional insufficiency of the shoulder and elbow joints. Although chronic inflammatory process with an immune component of varying intensity, more often of mild or moderate intensity, is the leading factor of damage to normal structures of the joints in late terms of the disease dystrophic and destructive changes in the articular ends of bones acquire the greatest value. More pronounced dystrophic, destructive and chronic inflammatory changes noted in the shoulder joint have corresponded to morphological picture of osteoarthritis of moderate or severe grade reflecting as individual metabolic processes, topography and activity of rheumatoid inflammation as biomechanical features of the joints.
Redox Regulation of Plant Development

We provide a conceptual framework for the interactions between the cellular redox signaling hub and the phytohormone signaling network that controls plant growth and development to maximize plant productivity under stress-free situations, while limiting growth and altering development on exposure to stress.Enhanced cellular oxidation plays a key role in the regulation of plant growth and stress responses. Oxidative signals or cycles of oxidation and reduction are crucial for the alleviation of dormancy and quiescence, activating the cell cycle and triggering genetic and epigenetic control that underpin growth and differentiation responses to changing environmental conditions.The redox signaling hub interfaces directly with the phytohormone network in the synergistic control of growth and its modulation in response to environmental stress, but a few components have been identified. Accumulating evidence points to a complex interplay of phytohormone and redox controls that operate at multiple levels. For simplicity, we focus here on redox-dependent processes that control root growth and development and bud burst.The multiple roles of reactive oxygen species in the control of plant growth and development have been identified, but increasing emphasis should now be placed on the functions of redox-regulated proteins, along with the central roles of reductants such as NAD(P)H, thioredoxins, glutathione, glutaredoxins, peroxiredoxins, ascorbate, and reduced ferredoxin in the regulation of the genetic and epigenetic factors that modulate the growth and vigor of crop plants, particularly within an agricultural context.
MULTIHAZARD FRAMEWORK for WATER RELATED RISKS MANAGEMENT

Effective natural and man-induced disaster management needs to be addressed through a complex preparedness-response-mitigation-rebuild cycle to be implemented at different and synergic levels in the ADRION countries. The MUHA project will connect the observed and modelled hazards and risks related to the integrated water cycle with the existing and improved coping capacity developed by national, bilateral and EU Civil Protection Mechanisms, following the rationale defined by the Sendai framework. Four water related risks will be addressed, regarded as components of one single complex water system prone to different hazards: accidental pollution, flooding, drought and failure of critical infrastructure due to earthquakes. Current status of water system and multi-hazard anticipated scenarios must result in complex disaster response mechanisms. The MUHA rationale is based on the necessity to effectively link different aspects of the water cycle in an improved response system, which will integrate functions of the analysis, forecasting and incident command systems, to be integrated in Common Alerting Protocols, thus enabling efficient transnational response. The interconnected role of water utilities through the water safety plans and civil protection mechanisms is crucial and currently not sufficiently harmonized. While the involved countries have already developed own different planning and response mechanisms at different levels, MUHA is expected to produce a long-term robust networking, based on a joint transnational management to address the common challenges of water-related response to hazard. Moreover, the definition of common action plans, methods and tools to be implemented in pilot actions are expected to improve response time and effectiveness of the coping capacity developed by national, bilateral and EU Civil Protection mechanisms.
Cooperation Incentives and Downlink Radio Resource Allocation for Green Communications in a Heterogeneous Wireless Environment

In a heterogeneous wireless medium, base stations (BSs) with overlapped coverage can cooperate for power saving through efficient radio resource allocation to mobile terminals (MTs) with multihoming capabilities. Specifically, an MT can aggregate the offered radio resources from different BSs to satisfy its required service quality at reduced BS power consumption. Unlike the existing works, we investigate green communications in a multioperator system where BSs are operated by different service providers. In such a scenario, cooperation among different networks is favored only if it results in a win–win situation among the service providers. Toward this end, we propose a decentralized downlink radio resource allocation strategy that guarantees mutual benefit (power saving) among different service providers. Simulation results demonstrate that the proposed strategy offers incentives to different service providers to cooperate for power saving, as opposed to the existing mechanisms that assume the networks are willing to cooperate unconditionally and saves more power, as compared with the noncooperative mechanisms.
Drehunterstützung für Z Invest Sp. z o.o.

Das Projekt betrifft die Unterstützung des Unternehmers bei der Bereitstellung finanzieller Liquidität und die Unterstützung laufender Tätigkeiten aufgrund finanzieller Schwierigkeiten, die der Unternehmer infolge des COVID-19-Ausbruchs erlebt hat. Finanzielle Unterstützung im Rahmen des Programms SA.57015 (2020/N)
PREMIX BURNER

The invention relates to a premix burner comprising a turbulence generator (7) for a combustion air flow and means for injecting the fuel into the combustion air flow. The turbulence generator (7) comprises one or more combustion air inlets for the combustion air flow entering the burner. The means for injecting fuel into the combustion air flow comprise one or more first fuel feed elements (8) with first fuel outlets (4). The opening diameter of the outlets and/or the injection angle thereof relative to the axial and/or radial direction is configured differently. Alternatively or additionally, some of the first fuel outlets (4) can be arranged in one or several first groups of fuel outlets which are arranged close to each other, such that each of the first groups produce a fuel jet having a large jet cross-section. The inventive burner enables improved premixing of fuel with the combustion air, especially when the fuel is injected into the combustion chamber end of the burner.
Storytelling for User Experience: Crafting Stories for Better Design

We all use stories to communicate, explore, persuade, and inspire. In user experience, stories help us to understand our users, learn about their goals, explain our research, and demonstrate our design ideas. In this book, Quesenbery and Brooks teach you how to craft and tell your own unique stories to improve your designs. Testimonials Stories facilitate a level of communication that is as close to telepathy as you can get. Kevin and guide you to use storytelling in `how to' scenarios so smoothly that you may never realize how far you leapfrogged ahead and never know the mistakes you didn't make because of this book. It's that good. Annette Simmons, author of The Story Factor A very practical, readable survey of ways to use one of the world's oldest and most powerful transmedia formsstorytellingto increase the coherence and effectiveness of digital artifacts. Brooks and Quesenbery offer concrete strategies for creating a richer design process and more successful user experiences. Janet Murray, Director of Graduate Studies, Digital Media M.S./Ph.D. Program, Georgia Tech Whitney and Kevin clearly articulate the power and effectiveness of storytelling for understanding users and communicating their real experiences to all project stakeholders. Their guidelines for integrating storytelling into user research and design have already given me new ways to help my clients better know their users and deliver great products and services. This is a reference will be reaching for regularly. Karen Bachmann, Partner, Seascape Consulting I have been tantalized by the power of the story to impact so many facets of the user experience process. The arrival of this thoughtful, actionable, and wide-ranging book is a glorious day! Steve Portigal, Principal, Portigal Consulting
Direct evidence to support the restriction of intramolecular rotation hypothesis for the mechanism of aggregation-induced emission: temperature resolved terahertz spectra of tetraphenylethene

In contrast to the traditional fluorescent dyes that exhibit a decrease in fluorescence upon aggregation, Aggregation-Induced Emission (AIE) molecules are a family of fluorophors which exhibit increased fluorescence upon aggregation. Consequently, AIE molecules represent an interesting new material with potential applications in fluorescent chemo/biosensors, light emitting devices and medical diagnostics. Numerous mechanisms have been proposed to explain this phenomenon, including E–Z isomerization, and restriction of intramolecular rotations (RIR). However, there has not been any direct experimental evidence to support either one of these hypotheses. Here we use terahertz time-domain-spectroscopy (THz-TDS) and solid-state computational simulations of an AIE molecule to link the increase in intensity of intramolecular rotation and rocking modes to the measured fluorescence and reveal direct evidence supporting the RIR hypothesis. This is the first time that terahertz spectroscopy has been used to directly probe such molecular motions in AIE materials and in doing so we have found conclusive evidence to fully explain the AIE mechanism.