SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Motor recovery with paired associative stimulation (recoverix)

Patients around the world need therapy to improve motor function. Motor disabilities may result from many causes, including traumatic brain injury (TBI), stroke, congenital conditions and some diseases. Rehabilitation therapy at a major hospital or rehabilitation center is expensive, time-consuming, and rarely results in major improvements, especially in the short term. However, new research from G.TEC and others has shown that practical brain-computer interface (BCI) systems can substantially improve motor rehabilitation outcomes without extensive additional burden on patients, therapists, or carers. Doctors and therapists can monitor patients and make adjustments with telemonitoring tools, supported by a decision support system to facilitate initial diagnoses and therapy planning, assess trends, automatically adapt feedback parameters and recommend changes. While these tools are not (yet) viable for home use, they will be usable in some field locations such as outpatient centers, reducing the need to travel to a major hospital or rehab center for therapy. RecoveriX will also develop, pilot-test, and launch a novel business focused on providing support for patients, their carers and clinicians. Our product and supporting business will be evaluated through “rehab testing rooms” with hospital subcontractors working with patients. This evaluation will support our Commercialization Plan, along with user, market and IP research, targeted surveys of end users, business experts, researchers and other groups, Workshop Tours, and other activities. Our efforts will be supported by a strong Advisory Board and subcontractors with specific, targeted expertise. Our proposal includes mechanisms for progress monitoring and expansion in Phase III. Overall, RecoveriX will create and exploit new opportunities in the health care market, with a strong impact on patients’ therapy opportunities and outcomes, costs to patients and carers, and the medical community.
Modeling and simulation with molecular dynamics of the edge dislocation behavior in the presence of Frank loops in austenitic stainless steels Fe-Ni-Cr

Austenitic stainless steels are widely used in the nuclear industry as internals. These structures reside mainly in the reactor vessel and, due to their proximity with fuel assemblies, are subjected to severe operating conditions. These elements are exposed to high irradiation doses which can reach 100 dpa after 40 years of operating, at a temperature close to 350°C. These operating conditions affect the microstructure of steels and their mechanical behavior, which leads to the deterioration of their mechanical properties and their corrosion resistance. The objective of this PhD research work is to establish at the atomic scale a constitutive law describing the edge dislocation motion in a random Fe-Ni10-Cr20 solid solute solution, to bring a comprehensive understanding of the interaction mechanism between the edge dislocation and the Frank loops and to investigate the effect of temperature, alloying random generator, orientation and size of the Frank loop on the mechanical stress. To achieve these objectives, molecular dynamics simulations were conducted with a recently developed FeNiCr potential used to mimic the behavior of austenitic stainless steels. These simulations have been performed in static conditions as well as at 300 K, 600 K and 900 K and the interactions realized for loop sizes of 2nm and 10nm. A constitutive law taking into account the temperature and strain rate is proposed; the interaction between the edge dislocation and the Frank loop revealed 3 kinds of interaction mechanisms: simple shearing, unfaulting and absorption of the loop. Absorption is the most stable mechanism; the analyses of the resulting mechanical properties have shown that the unfaulting mechanism requires the highest stress to make the dislocation overcome the obstacle. On the other hand, contrary to previous studies, the unfaulting of the loop surface occurs only when the dislocation comes into contact with the edge dislocation; for the 2 nm Frank loop size, the coupling between the probability of the outcome of the reaction and the average strength of the obstacle constitutes useful data for Dislocation Dynamics simulations. The observations of the resulting Frank loop configurations following the interaction with the dislocation allow justifying the emergence of clear bands observed in TEM. This work has been partially supported by the European Commission FP7 with the grant number 232612 as part of the PERFORM 60 project.
Western Beringia (Northeast Asia)

Abstract Archaeological and paleogeographic evidence suggests that Northeast Asia (Western Beringia) was a starting point from which prehistoric man began to explore the Western Hemisphere via the Bering Land Bridge. Current data suggest that the exploration by humans of the arctic zone of Western Beringia occurred no later than the second half of the Late Pleistocene, during the time span with favorable conditions for human dispersals. The Yana Site witnesses that at the end of the Karginsky, Paleolithic man almost reached the modern arctic coast at the Indigirka-Kolyma lowlands. Later, during the Sartan, some new complexes (cultures) appeared, represented by those sites as Khaya IV, Kheta, Druchak, Ushki I to V, etc. Changing landscapes and climates of Western Beringia in the Early Holocene provoked new developments and the disappearance of the Paleolithic cultures, which were replaced by the Mesolithic cultures more adapted to the new conditions.
Abelianisation of connections, quantum curves, and spectral clusters

This cross-disciplinary project lies at the interface of geometry, mathematical physics, perturbation theory, and integrable systems, combining techniques from algebraic topology, cluster algebras, ordinary differential equations, and asymptotic analysis. The main goal is to advance our understanding of the geometry of character varieties and their quantisation. This project -- carried out by Nikita Nikolaev under the supervision of Marta Mazzocco at the University of Birmingham -- is expected to result in a fundamental innovation in geometry and have important implications for quantum field theory. It will open a vast new scientific arena and will serve to establish Nikolaev amongst research leaders in this highly active research area.  Character varieties are geometric spaces which are ubiquitous in mathematics and physics, where they capture important topological and quantum invariants. These spaces parameterise singular complex ordinary differential equations (such as the Airy and Bessel equations, or even time-independent Schrödinger equations), as well as their generalisations: meromorphic connections on vector bundles over a Riemann surface. However, character varieties are usually complicated singular spaces, so the valuable information they encode is not easy to access. This project will develop a new method to describe character varieties called abelianisation. Ideas behind abelianisation stem from the WKB method in quantum mechanics and have recently resurfaced in the context of quantum field theory and string theory. Abelianisation will allow to construct special coordinate systems on character varieties (called spectral coordinates) which naturally capture crucially important geometric structure of character varieties (most prominently the symplectic and cluster structures). In other words, spectral coordinates will be a geometric gadget to decrypt mathematical and physical information encrypted in character varieties.
Un sistema di previsione e prevenzione dell’impatto variabilità delle condizioni climatiche sulla variabilità del rischio per l’ambiente vegetato ed urbano

The project addresses issues related to climate change and its impacts on the natural environment (forest and agricultural areas) and man-made, with particular reference to conditions of risk induced by these changes. The overall objective is to provide to the affected areas, which have strong similarities between their morphological and land use, common tools to counter the negative effects of climate variability on risk conditions. The target areas include the areas of Corsica, Liguria and Sardinia. Some activities will be focused on pilot areas, selected on the basis of their significance in relation to the issues addressed. The final beneficiaries of the project will be the local governments involved in risk prevention. Some activities will have direct impact on local organizations (eg, voluntary groups) or on the population exposed to the risks. The project includes activities devoted to the deepening of understanding and developing models to assess the hazards of forest fires, also in relation to climate variability. It 'also planned to adopt a single integrated platform for the prediction of geological hazards and fire, and the identification of pilot projects for the redevelopment of areas at risk, including through the identification of sustainable land use practices. Key elements are the training programs for local governments and information campaigns targeting the population subject to the risk. Finally, activities are planned to disseminate the results by conducting workshops and the preparation of joint publications
The Organization of Irrational Beliefs in Posttraumatic Stress Symptomology: Testing the Predictions of REBT Theory Using Structural Equation Modelling

This study directly tests a central prediction of rational emotive behaviour therapy (REBT) that has received little empirical attention regarding the core and intermediate beliefs in the development of posttraumatic stress symptoms.A theoretically consistent REBT model of posttraumatic stress disorder (PTSD) was examined using structural equation modelling techniques among a sample of 313 trauma-exposed military and law enforcement personnel.The REBT model of PTSD provided a good fit of the data, χ(2) = 599.173, df = 356, p < .001; standardized root mean square residual = .05 (confidence interval = .04-.05); standardized root mean square residual = .04; comparative fit index = .95; Tucker Lewis index = .95. Results demonstrated that demandingness beliefs indirectly affected the various symptom groups of PTSD through a set of secondary irrational beliefs that include catastrophizing, low frustration tolerance, and depreciation beliefs.Results were consistent with the predictions of REBT theory and provides strong empirical support that the cognitive variables described by REBT theory are critical cognitive constructs in the prediction of PTSD symptomology.
Near-Infrared optoelectronic devices with atomically controlled graphene nanostructures

The extraordinary and ultrafast electro-optical response of graphene nanostructures has enabled order-unity changes in absorption due to the switching on and off of plasmons via electrical gating, thus suggesting application to ultrafast light modulation. Unfortunately, graphene plasmons have so far been observed at mid-infrared and longer wavelengths, therefore limiting their use as optoelectronic devices in the visible and near-infrared (vis-NIR) spectral range. Reaching this energy regime requires an efficient doping of graphene by confining the lateral dimension below 5 nm, which is beyond the state-of-art top-down lithography resolution. Alternatively, this project will use a bottom-up chemical route recently developed by the host organization to synthesize atomically precise, 1nm wide, graphene nanoribbons (GNRs) that can couple laterally to give rise to either nanoporous graphene structures or laterally interconnected GNRs arrays, for efficient gate-doping. The project aims to explore the feasibility of fabricating optoelectronic devices based on the plasmonic properties of atomically precise graphene nanostructures. The nature of the project is highly multidisciplinary, involving a combination of well-developed chemistry, physics, electronics and photonics that will focus at three different levels: chemical synthesis of atomic-size GNRs and characterization, nanostructure transfer and device fabrication, and electro-optical characterization. This proposal promotes both the transfer of knowledge to the host institution and the training of the candidate in new advanced techniques. The proof-of-concept of such device will pave the way for ultra-high speed photodetectors that are capable of handling record data transmission at vis-NIR range, thus providing key solutions for next generation data communications. This project lines up perfectly with the EU strategy, “Graphene Flagship”, in fostering the emergence of foundational breakthroughs in graphene science.
Overexpression of hepatitis B x-interacting protein in HepG2 cells enhances tumor-induced angiogenesis

Hepatocellular carcinoma (HCC) is a common malignancy and a leading cause of cancer death worldwide. Hepatitis B x-interacting protein (HBXIP), a cofactor of survivin, was originally identified by binding with the C-terminus of the HBx and negatively regulated the activity of HBx. In this study, the effect of HBXIP on the hepatoma cells-induced angiogenesis was investigated. Proliferation and migration of human umbilical vein endothelial cells (HUVECs) were detected by MTT and transwell assay, respectively. Tube formation and chick chorioallantoic membrane model were used to observe the angiogenesis. Vascular endothelial growth factor activity was assayed using ELISA kits. Western blotting was performed to examine the protein expression. Our results indicated that overexpression of HBXIP increased HepG2 cell-induced endothelial cells migration, proliferation, and angiogenesis, which may be related to increasing phosphorylation of endothelial NO synthase in HUVECs. These results suggest that HBXIP may play an important role in tumorigenesis by enhancing angiogenesis in HCC.
Healthcare Cross-border Cooperation

Co.Sa.T's aim is to improve medical check-ups for people living in rural and near-borders areas and living with addition-related issues (alcohol, game and cannabinoids). People living in this conditions face several problems: difficulties in access health services due to the territorial morphology; lack of information about the patients between cross-border services; different monitoring and treatment protocols on both sides of the border. Co.Sa.T. addresses to addiction-suffering users (final beneficiaries) and to operators and administrators of healthcare services designated to their follow-up (intermediate beneficiaries).
Water deflector for decking

A deck 6, attached to a wall 1 of a building, comprises a plurality of boards 6 mounted onto a framework 2, 5 fixed 3 to the wall, and including an elongate member 7 attached to the upper surface of the deck and adjacent the wall so as to deflect water, especially rain water 10, from the wall. The member 7 is preferably attached to the deck by plastics wedges 8 having on their lower and upper faces an array of ribbed and recessed areas (Fig 2, not shown), the ribbed areas enhancing the grip between the wedges and both the deck boards and the elongate member, and the recessed areas providing fixing surfaces.
Psychiatric disorders: atx-inhibiting drugs as a new therapeutic option: proof-of-concept

Within the frame of the ERC LiPsyD we have shown that recently discovered that the phospholipid LPA acts as a synaptic modulator playing a major role in regulating cortical excitability and being involved in psychiatric disorders (Trimbuch et al., 2009; Unichenko et al., 2016; Vogt et al., 2016; Vogt et al., 2017). Using specific small molecule inhibitors like PF8380, which target the LPA-synthesizing molecule autotaxin (ATX), we were able to decrease cortical hyperexcitability and to rescue disease-specific behavior in different animal models for schizophrenia to wild type (WT) levels. These results generated within the ERC LiPsyD demonstrate that ATX-inhibition is effective in treating psychiatric disorders (Vogt et al., 2016). Since current therapy for schizophrenia targeting cortical hyperexcitability is not available, ATX-inhibitors which act on excitatory neurotransmission and are effective in treating psychiatric disorders have a huge commercial potential in this  120 billion euro market (Olesen et al., 2012). 
To proceed towards the commercial application of ATX-inhibitors, the PI has teamed up with Merck and was granted a patent for the use of ATX-inhibitors for brain disorders (WO 2017/071799). Briefly, the patent covers the use of the ATX-inhibitors for the therapy of brain diseases (covering psychiatric disorders like schizophrenia and eating disorders but also cerebrovascular disorders) and the use of a latest generation of ATX-inhibitors (MSC 2285264 and MSC2358829), which are comparable to the most potent currently available ATX-inhibitors, are suitable for in-vivo application and have a positive toxicological profile. However, before starting clinical trials, the pharmacological profile and the effectiveness of the novel ATX inhibitors for treatment of psychiatric disorders have to be assessed. This PoC aims therefore to the preclinical characterization of these ATX-inhibitors which is a critical step towards their commercialization
The basic characteristics of internal magnetic field in Mongolia and its adjacent

Based on the eleventh generation of international geomagnetic reference field(IGRF) model and the NGDC- EMM- 720- V3 model of crustal magnetic field,this paper aims to analyze the vertical component of the main magnetic field,the non dipole field,secular variation,long- term acceleration and crustal magnetic anomaly above the surface and the surface of different height distribution in Mongolia and its adjacent area,and to discuss the relationship between the crustal magnetic anomalies and geological structure. The results show that spatial changes of the main magnetic field components in Mongolia and adjacent areas is small,crustal magnetic shows slug,ribbon,arc shaped and the distribution is relatively complex. The anomaly center of Ulam Uhde and Ulan Bator area are relatively stable. Mountain Hangai and Mountain Altai present negative magnetic anomaly,the anomaly distribution is consistent with the mountain tectonic trends. The transition area of positive and negative magnetic anomaly is basically consistent with the boundary of the mountain and basin.
SYSTEM AND METHOD FOR PROVIDING ELECTRONIC INFORMATION UPON RECEIPT OF A SCANNED BAR CODE

A system and method are provided for receiving a bar code from a user, retrieving information concerning an item identified by the bar code, and providing the information to the user. The information may include a hyperlink, a description, summary or review of the item, network address, etc. Producers, vendors, manufacturers and other entities may register bar codes and information about items, including electronic commerce opportunities. A graphical display returned to a user may thus include various product details, advertisements, purchasing opportunities and other data. The graphical display may be tailored to a particular entity, such as the operator of the system or an organization that provided the user with a bar code scanner. The system includes one or more databases to store registered bar codes, information relating to items and components of graphical displays. One or more servers are also included, to maintain the databases and communicate with users and other entities.
Goal-oriented space-time adaptivity in the finite element Galerkin method for the computation of nonstationary incompressible flow

SUMMARY
This paper presents a general strategy for designing adaptive space–time finite element discretizations of the nonstationary Navier–Stokes equations. The underlying framework is that of the dual weighted residual method for goal-oriented a posteriori error estimation and automatic mesh adaptation. In this approach, the error in the approximation of certain quantities of physical interest, such as the drag coefficient, is estimated in terms of local residuals of the computed solution multiplied by sensitivity factors, which are obtained by numerically solving an associated dual problem. In the resulting local error indicators, the effects of spatial and temporal discretization are separated, which allows for the simultaneous adjustment of time step and spatial mesh size. The efficiency of the proposed method for the construction of economical meshes and the quantitative assessment of the error is illustrated by several test examples. Copyright © 2012 John Wiley & Sons, Ltd.
Physiological and rehabilitation outcomes: gains from automated interventions in stroke therapy (pro gait)

Developments in robotics allow people with profound neuromuscular deficits after stroke to walk with assistance (during the gait cycle) using an exoskeleton robot. Integrating a robotic device with individualised user electroencephalography (EEG /electrical activity in the motor areas in the brain) and EMG (muscle)feedback would allow more physiological and targeted gait parameters in response to effort, and  confer neuroplastic training effects including neuromodulation of temporal and spatial features of gait.
Future integration of EEG/EMGsignals with robotic devices will allow patient initiated movement through thought and/or attempted effort, where currently parameters for devices are therapist set and usage is not functionally driven by the patient. Advancement in this regard is stalled primarily because of difficulty in 3D modelling of gait by EEG. 
This collaborative consortium through secondments and return and built in knowledge sharing strategies will exchange knowledge and expertise across: Design, development and production of exoskeleton gait devices; neuro-rehabilitation; bioelectric EEG/EMG signal capture and interpretation; mathematical modelling and brain computer interface (BCI) platform development can advance the state of the art in gait rehabilitation after stroke rehabilitation. The proposal  will allow development of 3D modelling of gait, for gait restoration  and explore integration  with robotics from multi-stakeholder perspectives.
Aims:
1. Define current state of the art in EEG modelling of gait post stroke by systematic review and meta-synthesis
2. Complete 3D modelling of gait as visualised gait, overground gait and robotic walking in healthy individuals and stroke survivors
3. Develop and test a virtual reality BCI gait training device, including end-user feedback
4. Explore integration of this prototype with robotic software platforms
DA.NI.MAC S.N.C. OF MATTEO DAMIANO & C.

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