SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Methods for the Treatment of Cancer, Inflammatory Diseases and Autoimmune Diseases

The invention relates to methods and pharmaceutical compositions for the treatment and diagnosis of cancer. The invention also relates to methods and pharmaceutical compositions for the treatment of inflammatory diseases and autoimmune diseases. The inventors investigate the role and specific contribution of extracellular vesicles (EVs) in cancer environment. The inventors demonstrate that CSF1-associated EVs induce macrophage signature associated with T cell infiltration and extended patient survival. The inventors demonstrate that via specific extracellular vesicles, these tumors promote pro-inflammatory macrophages correlated with better clinical outcome and a better prognosis in TNBC patients. In the present invention, the inventors provide in vitro evidences towards a direct role of CSF1-associated EVs as tools, alone or with other immuno-therapies, to promote anti-tumor immune responses. Thus, the present invention relates to CSF1-associated EVs, their use in the treatment and diagnosis of cancer, and their targeting in the treatment of inflammatory diseases and autoimmune diseases.
DUAL FLUSH DEVICE

The devices and methods described, provide for a dual flush device with a handle sleeve with a rotation stop and a lift arm extending through the handle sleeve with a rotation limiting tab on the lift arm to engage the rotation stop to enable the lift arm to rotate in a first direction through a first arc and to rotate in a second direction through a second arc where the first arc is smaller than the second arc. A dual flush device with a lift arm added to conventional toilet will enable the toilet to perform two different flush actions, a small partial flush for liquid waste, and a second, full flush for solid waste.
Secondary Dispersal Of Willow Seeds: Sailing On Water Into Safe Sites

Abstract Willows (Salix spp.) produce many small seeds that are dispersed primarily through the air by winds (anemochory) and sometimes secondarily by flowing water (hydrochory). In this paper I identify another way willow seeds are dispersed – being blown by winds while sailing or floating on the surface of standing water, here termed pleustochory. In experiments, seeds of Salix gooddingii C.R. Ball floated on water for four days and sailed swiftly on the surface of pools when light winds blew, reaching speeds in excess of five meters per minute. Field observations showed that S. gooddingii seeds sailing on water were blown downwind and soon came to rest at the edge of the pool, in their preferred safe sites. This dispersal via pleustochory from unsuitable sites (middle of a pool) into safe sites (edge of pool) is therefore a new example of directed dispersal. Salix gooddingii seed dispersal and seedling densities were studied at a large, remote pool in the Tijuana River Valley, San Diego Co., to examine...
GAS-BURNER DEVICE AND METHOD FOR OPERATING A GAS-BURNER DEVICE

The invention relates to a gas-burner device and to a method for operating a gas-burner device, comprising a conveyor device (1) for conveying a gaseous fuel to a burner (2) and comprising a recirculation device (3) for recirculating an exhaust gas quantity produced during the combustion of the fuel to the burner (2). It is essential to the invention that a sensor device (4) is provided for ascertaining the composition of the fuel, and the recirculation device (3) is designed to be controlled on the basis of the fuel composition detected by the sensor device (4).
METHODS AND APPARATUS FOR PRODUCING ALKYL ESTERS FROM LIPID FEED STOCKS AND SYSTEMS INCLUDING SAME

The present invention relates to methods and apparatus for producing alkyl esters from lipid feed stocks, such as plant oils and/or animal fats, and systems including the same. In an embodiment, the invention includes a process for producing alkyl esters including mixing a lipid feed stock with an alcohol to form a reaction mixture; and contacting the reaction mixture with a catalyst under supercritical conditions for the alcohol, the catalyst comprising an unmodified metal oxide selected from the group consisting of alumina, titania, zirconia, and hafnia, and removing residual free fatty acids from the reaction mixture. Other embodiments are included herein.
Sustainable agricultural eco-system: business and technological solution for eco-conscious vegetable cultivation using on-site produced algae fertilizer

Both regulations and costumer needs resulted in expansion of the market for green labelled food products cultivated at sustainable way. Nevertheless, the availability of affordable technological tools for the production of green vegetables is limited. Furthermore vegetable suppliers (in Europe typically farmers with small land) neither have the essential technological knowledge nor the willingness to change the cultivation methods. Realizing these trends, Vegetable Trading Centre (VTC), a regional market leader of Vegetable production and trading, and Multisense, a technology intensive start-up, put together this proposal, aiming at the establishment of a sustainable agricultural eco-system. An innovative technology for on-site production of microalgae and their usage as bio-fertilizer in vegetable cultivation has been piloted at VTC. In the proposed business model, this technology will be sold to framers helping them to make microalgae based fertilizer on their own land at cost-effective eco-friendly way. The trader (Vegetable Trading Center) guarantees to buy the vegetables produced this eco-conscious way and bring them to superstores at high price. In this phase 2 proposal we target to upgrade and generalize the pilot site to a commercial technology, obtaining upgraded sensor and control system, make generalized designs, user manuals and descriptions, use cases, as well as demonstrate the efficiency in extensive field trials. Furthermore, starting with the suppliers of VTC, we aim at expand our business model to Europe and carry out the early marketing actions within the project.
Monomer sequence control in polymers : toward next-generation precision materials

The aim of the project “Euro-Sequences” is to establish a multidisciplinary training network on the emerging topic of sequence-controlled polymers. It has been shown during the last 5 years that such polymers open up unprecedented options for the future of manmade materials. Indeed, similarly to biopolymers such as DNA and proteins, synthetic sequence-controlled polymers contain precisely engineered chain-microstructures that allow a fine control over their molecular, nanoscopic and macroscopic properties. For instance, these new types of polymers are relevant for applications in molecular data storage, catalysis, and nanomedicine. However, this field of research is young and therefore, fundamental and applied research is still mandatory. Thus, it seems timely and appropriate to federate top-European researchers working on that topic. The proposed network is composed of 7 academic partners and 2 companies and connects researchers with complementary expertise in areas such as organic chemistry, polymer synthesis, supramolecular chemistry, physico-chemistry and materials science. This multidisciplinary network will focus on different scientific aspects. A first important objective will be the development of facile and rapid chemical methods for ‘writing’ molecular information on polymers. In addition, analytical techniques that allow characterization and sequencing of polymers will be studied. The folding and self-assembly of sequence-controlled polymers will be also examined in order to understand the correlation between controlled primary structure and higher levels of organization. Eventually, a crucial aim of this project will be the conception of new types of plastics materials. This network will be a unique scientific environment for training PhDs. The students will conduct their research in top-European laboratories and will receive a complete training, including lectures and summer schools, on polymer chemistry, supramolecular chemistry and biomaterials.
ARRANGEMENT FOR CONTINUOUSLY CONTROLLING THE CAPACITY OF A REFRIGERATING MACHINE

Arrangement for continuously controlling the refrigerating capacity of a refrigerating machine, comprising a closed refrigeration cycle with evaporator (3), compressor (5) and condenser (2). Instead of an expansion valve, an electronically controlled control valve is proposed. Control parameters of the medium to be cooled are compared with predetermined target values in a control device (RR). The control valve is set in function of the difference between control parameter and target value. The valve setting governs the flow of refrigerant and hence the corresponding refrigerating capacity. To achieve optimal filling of the evaporator at full load, an additional control device (DR) monitors the minimal difference between suction gas temperature and evaporating temperature. To prevent an excessive drop in evaporating pressure under partial load, an automatic hot gas bypass control device (7) arranged between the high-pressure line and the evaporator feeds substitute gas to the supplier immediately the suction pressure falls below a given value. To protect the compressor from excessively high temperatures, the suction gas control device (RS) opens the control valve until the suction gas temperature falls to the permissible value.
THREE BY FOUR CAN PACKAGE DISPENSING CARTON

A carton with an improved dispenser at an end of the carton which preserves the integrity of the carton when it is opened while permitting the bottom end flaps attached to the bottom panel to remain in place and also a portion of each side end flap that overlaps the bottom end flaps. This dispenser has a bottom tear line in the end of the carton which only extends partially across the end of the carton. The tear line extends upwardly from each side of the bottom tear line to form end retainers to prevent cans in the second row of the carton from rolling out. By placing the bottom tear line no higher from the bottom of the carton than necessary to retain a can in the bottom row and to make the end retainers on each side of the carton no larger than necessary to restrain a can in the second row from rolling out, easy access to the cans on the bottom row of containers is provided after the cans in the second and third rows of the carton have been removed. This dispenser may also provide a safety net for the first can dispensed. The top tear line in the top panel for forming the dispenser flap is located from the exiting end of the carton at a distance that is significantly less than the diameter of a can to be contained in the carton. Preferably this distance is between 70 and 85% of the diameter of a container to be contained in the carton, but can be as short at 50% of the diameter of a container plus approximately three millimeters.
Bioelectricity generation from coconut husk retting wastewater in fed batch operating microbial fuel cell by phenol degrading microorganism

Dual chamber microbial fuel cell (MFC) operated at fed batch mode for the treatment of retting wastewater has potently achieved both current generation and phenol removal. Hydraulic retention time (HRT) of the reactor was varied from 40 days to 10 days. COD (chemical oxygen demand) removal was 91% at 40 days HRT, with an initial COD concentration of 530 ± 50 g m−3. Retting wastewater with an initial phenol concentration of 320 ± 60 g m−3 procured a highest phenol removal of 93% at 40 days HRT of the microbial fuel cell. Maximum power density of 362 mW m−2 was achieved using retting wastewater at HRT of 20 days with an internal resistance of 150 Ω in a dual chambered MFC. The bacterial strains in anode region, reported to be responsible for potential phenol removal, were identified as Ochrobactrum sp. RA1 (KJ408266), Ochrobactrum sp. RA2 (KJ408267) and Pesudomonas aeruginosa RA3 (KJ408268) using phylogenetic analysis. The study reveals that, dual chambered MFC effectively removed the phenol from retting wastewater along with power generation.
The retinae as windows to the brain: an oscillatory vision

Several sophisticated image processing circuits have been discovered in the animal retina, many of which manifest massive neural synchrony. A major insight is that this type of synchrony often translates to high-frequency activity on a macroscopic level, but electroretinography (ERG) has not been tapped to examine this potential in humans. Bolstered by our compelling results combining ERG with magnetoencephalography (MEG), this project will address several open questions with respect to human visual processing:

1) Could variable retinal timing be linked to intrinsic image properties and pass on phase variance downstream to visual cortex? Our data suggests the retina responds to moving gratings and natural imagery with non-phase-locked high gamma oscillations (>65 Hz) just like visual cortex, and that slower ERG potentials exhibit strong phase-locking within stimuli but large phase variance across stimuli.

2) Do such retinal gamma band responses, both evoked and induced, directly drive some cortical gamma responses? Pilot data suggests that it can, through retinocortical coherence, our novel ERG-MEG mapping technique.

3) Several kinds of motion have now been shown to elicit massive synchrony in mammalian retina circuits. Does this also result in macroscopic high-frequency activity? If so, our experiments will finally reveal and characterize motion detection by the human retina.

4) Do efferent pathways to the retina exist in humans? We discovered that the ERG exhibits eyes-closed alpha waves strikingly similar to the classic EEG phenomenon and, leveraging our retinocortical coherence technique, that this activity is likely driven by contralateral occipital cortex. Then, can retinal responses be influenced by ongoing cortical activity?

Characterizing retinocortical interaction represents a complete paradigm shift that will be imperative for our understanding of neural synchrony in the human nervous system and enable several groundbreaking new avenues for research.
Experimental Study on the Movement and Deformation of Rock Strata Between Coal Seams in the Coal Mining Above Gob Area

To guarantee safety and high productivity of the left-over coal seam mining above gob area,and considering the importance of the movement and deformation of rock strata between coal seams,we use similar simulation experiment to study the movement and deformation rules of rock strata in the same horizontal layer and vertical measuring position in the mining process.The results show that original three zones of the lower coal seam develop upwards and a controlling stratum presents duo to the mining operation of upper coal seam above gob area.Additionally,the deformed basins are formed among the rock strata,and the strata under the controlling stratum appear subsidence basin,while the strata above the controlling stratum appear fractal basin.Meanwhile,the subsidence of the strata in the same level moves asymmetrically as a whole as the working face advances.During the process of movement and deformation,the strata above the controlling stratrum move continuously,while the strata under the controlling stratum move discontinuously.
Cognitive Impairment and EAT

Abstract This chapter discusses the influence of cognitive impairment in the prescription and effective use of electronic assistive technology (EAT). The authors consider the impact of cognitive, emotional and executive impairments on the use of EAT, and the effect of the course and prognosis of different types of neurodevelopmental versus acquired or progressive disorders. Self-awareness and motivation are also considered as key influences on the use and outcome of EAT. The effects of executive, attention and memory impairments on the ability to engage with technology and its implications for the uptake of EAT are explored, alongside strategies and technology developed to address these problems. The authors conclude the chapter by emphasising the importance of the development and improvement of affordable technologies with health applications. They highlight the usefulness of the neuro-socio-technical and technology acceptance models as a framework to adopt when prescribing EAT to people with cognitive impairments to fully consider the interplay between clinical presentation, social environmental factors and technological capabilities.
Reliability investigations for high temperature interconnects

Purpose – Because of the need for electronics use at temperatures beyond 150°C, high temperature resistant interconnection technologies like transient liquid phase (TLP) soldering and silver sintering are being developed which are not only replacements of high-lead solders, but also open new opportunities in terms of temperature resistance and reliability. The paper aims to address the thermo-mechanical reliability issues that have to be considered if the new interconnection technologies will be applied. Design/methodology/approach – A TLP soldering technique is briefly introduced and new challenges concerning the thermo-mechanical reliability of power devices are worked out by numerical analysis (finite element simulation). They arise as the material properties of the interconnect materials differ substantially from those known for soft solders. The effective material responses of the new materials are determined by localized unit cell models that capture the inhomogeneous structure of the materials. Findings – It is shown that both the TLP solder layer and the Ag-sinter layer have much less ductility and show less creep than conventional soft solders. The potential failure modes of an assembly made by TLP soldering or Ag sintering change. In particular, the characteristic low cycle fatigue solder failures become unlikely and are replaced either by metallization fatigue, brittle failure of intermetallic compound, components, or interfaces. Originality/value – A variety of new failure risks, which have been analyzed theoretically, can be avoided only if they are known to the potential user of the new techniques. It is shown that an optimal reliability will be strongly dependent on the actual assembly design.
Integration of recreation and tourism concerns in Natura 2000 management planning processes to support sustainability in the alpine area

The Alpine region contains a large number of valuable habitats and rare species of European interest, which are protected in Natura 2000 sites. They also host plenty of tourist destinations of European significance. Therefore tourist businesses are concerned that future development options may be severely limited and the recreational use of the landscape may be restricted, and that lack of information may lead to unjustified regulations. One crucial component for solving conflicts in Natura 2000 sites are management plans. This project will develop a management framework specific for sites with intensive tourism use. It will be developed and tested in several sites, and rely on comparative and standardised visitor monitoring methods, and appropriate forms of public participation that take the unique situations of tourist businesses into consideration. The project will also initiate a network of Natura 2000 sites and tourism destinations to share experiences and management options.
Crédito D’IMPOSTA — THAT CASTRO DEBORAH PASTICCINE & C. S.A.S.

LA EMPRESA QUE PARTICIPA EN LA PRODUCCIÓN DE PRODUCTOS FRESCOS DE PASTELERÍA Y HELADERÍA, CON UNA BARRA CONTIGUA, CON EL SIGUIENTE PROYECTO DE INVERSIÓN:
In-ear active noise reduction earphone

An active noise reduction earphone includes structure for positioning and retaining the earphone in the ear of a user and, active noise reduction circuitry including an acoustic driver with a nominal diameter greater than 10 mm oriented so that a line parallel to, or coincident with, an axis of the acoustic driver and that intersects a centerline of the nozzle intersects the centerline of the nozzle at angle ϑ>±30 degrees. A microphone is positioned adjacent an edge of the acoustic driver. The earphone is configured so that a portion of the acoustic driver is within the concha and another portion of the acoustic driver is outside the concha.
Chemoenzymatic synthesis of complex glycans to decipher the interactions between them and influenza a virus

Influenza A virus has two major envelope glycoproteins: HA and neuraminidase (NA). HA binds to sialic acid moieties of glycoconjugates of the host respiratory cells to initiate infection, whereas NA facilitates the release of progeny viruses from infected cells by cleaving sialosides. It is well documented that binding preference is a major determinant of influenza virus host range and avian viruses preferentially bind Neu5Acα(2,3)Gal, whereas human viruses bind Neu5Acα(2,6)Gal. This difference in specificity represents a barrier for transmission of avian viruses into humans. Glycan arrays have been used to assess influenza A virus receptor specificity. However, the currently available glycan arrays contain only a fraction of the glycans found on human airway epithelial cells and cannot uncover glycan binding specificities. Thus, we propose to develop an array that contains glycans representative of the structures found in human airways, since it is a priority in order to understand the biology of influenza virus transmission and pathogenesis. In addition, it has been described that there are two pathways by which influenza virus enters cells. It is believed that some N-glycans serve as attachment factors for concentrating virus particles on the surface of the host cells. However, only specific cell surface proteins modified by appropriate N-glycans can facilitate cell entry. The elucidation of the influenza virus receptor structure will unveil the mechanism at molecular level by which virus enters the cell. To this end, we will develop an experiment, which allows us to identify glycoprotein receptors of flu virus using cell surface glycan editing. The full comprehension of multi-branched glycans, along with the identification of the glycoproteins receptors of influenza virus, will allow the development of new and more efficient glycan-based therapeutics.
Twisted edwards-form elliptic curve cryptography for 8-bit AVR-based sensor nodes

Wireless Sensor Networks (WSNs) pose a number of unique security challenges that demand innovation in several areas including the design of cryptographic primitives and protocols. Despite recent progress, the efficient implementation of Elliptic Curve Cryptography (ECC) for WSNs is still a very active research topic and techniques to further reduce the time and energy cost of ECC are eagerly sought. This paper presents an optimized ECC implementation that we developed from scratch to comply with the severe resource constraints of 8-bit sensor nodes such as the MICAz and IRIS motes. Our ECC software uses Optimal Prime Fields (OPFs) as underlying algebraic structure and supports two different families of elliptic curves, namely Weierstras-form and twisted Edwards-form curves. Due to the combination of efficient field arithmetic and fast group operations, we achieve an execution time of 5.8 · 106 clock cycles for a full 158-bit scalar multiplication on an 8-bit ATmega128 micro-controller, which is 2.78 times faster than the widely-used TinyECC library. Our implementation also shows that the energy cost of scalar multiplication on a MICAz (or IRIS) mote amounts to just 19~mJ when using a twisted Edwards curve over a 160-bit OPF. This result compares fairly well with the energy figures of two recently-presented hardware designs of ECC based on twisted Edwards curves.