SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Postprogression survival of patients with advanced hepatocellular carcinoma: Rationale for second-line trial design

Sorafenib improves overall survival (OS) of patients with hepatocellular carcinoma (HCC) in the absence of objective response. Thus, time to tumor progression (TTP) is used to capture benefits of novel molecular agents, but proof of its surrogacy with survival is lacking. Furthermore, survival predictors upon progression are not established and there is a need to characterize postprogression survival (PPS) and assess with time-dependent covariates analysis if it is influenced by progression pattern, and not solely by simultaneous impairment of liver function and performance status. We prospectively followed HCC patients treated with sorafenib. Clinical and biochemical evaluation were done every 4 weeks. Radiologic assessment of progression was done at week 4 and then every 8 weeks using RECIST 1.1. The progression pattern was divided into: intrahepatic/extrahepatic increase in tumor size, new intrahepatic lesion, and new extrahepatic lesion (NEH). We included 147 patients (hepatitis C virus [HCV] 57.1%, performance status [PS] 0 83.6%, Child-Pugh A 82.3%, and BCLC-C 47.3%). The median OS was 12.7 months and its independent predictors (hazard ratio [HR], 95% confidence interval [CI]) were: baseline BCLC 2.49 [1.66-3.73], PS 1.86 [1.12-3.10], registration during follow-up of Child-Pugh B or Child-Pugh C scores (2.36 [1.51-3.69] and 2.89 [1.62-5.15], respectively), definitive sorafenib interruption 2.48 [1.54-4.01], and TTP 3.39 [1.89-6.1]. The presence of NEH 2.42 [1.32-4.44] is also an independent predictor of OS and PPS in patients with radiologic progression.Tumor progression is a surrogate of survival but its impact varies according to progression pattern. Thus, PPS is influenced by progression pattern and this is key in prognostic prediction and second-line trial design and analysis.
MELHORIA DO PROCESSO DE PRODUÇÃO PARA A REALIZAÇÃO DE PORTAS E JANELAS

L — A INTRODUÇÃO DE MÁQUINAS INOVADORAS E NOVAS FERRAMENTAS PERMITIRÁ QUE A EMPRESA INICIE UM PROCESSO DE INOVAÇÃO NA EMPRESA, O QUE MELHORARÁ OS TEMPOS DE PRODUÇÃO, BEM COMO AUMENTARÁ A QUALIDADE E O ACABAMENTO DAS PORTAS E JANELAS REALIZADAS.
ADAPTING SMES

Adaptation of the establishment and methods of organisation of work in the context of COVID -19 to comply with the standards and recommendations of the Competent Authorities
Sustainable management of water resources to safeguarding drinking water

The project aims to highlight the rich aquifer systems and seek methods for their protection. The main benefit of the project implementation is the rehabilitation of contaminated groundwater and the natural environment, optimizing the monitoring network of water basin and the optimal management of water resources. The project consists of the following: • Exchange of information and existing know-how in relation to the state of groundwater resources • A decision support system and a telemetric surveillance network, based on a GIS application, towards an integrated water resources management. Through this net the regional authorities will have the ability to monitor the actual situation of drinking water, in terms of quantity and quality and identify in an early stage the risks for aquifers pollution in order to take all necessary measures for prevention and restoration • A water management plan, through the use of the telemetric net and the DSS • Staff of the participating regions will be trained in implementing best practices
Impact of Liquidity Risk on Firm Specific Factors. A Case of Islamic Banks of Pakistan

The major objective of the study is to develop a model and to test the relationship among liquidity risk and firm performance through its facets.  The main facets of firm performance in the study are i-e profitability, firm size, leverage, share prices and earnings on assets. The present study mainly attempts to analyses qualitative, quantitative & contextual relationship of liquidity risk in Pakistan. Moreover, liquidity risk is less investigated in Pakistan and mainly regarding Islamic banking sector with respect to current data. Therefore, study is mainly investigated on the fourth pillar of significance i-e contextual significance. While, Islamic banking sector of Pakistan is investigated in current study. And the data is acquired from state bank of Pakistan database and through annual reports of the banks. Though, the study has supported past investigations results. Hence, the study has revealed key findings that will be fruitful for theorists, educationists and research scholars as well. Key w ords: Liquidity risk, Return on Assets, Profitability, bank size, leverage, Contextual study, Islamic banking, Pakistan.
ROOM TEMPERATURE CURABLE SILICONE ELASTOMER COMPOSITION

By preparing a one part silicone RTV composition with a high initial uncured plasticity, specifically a Williams plasticity of from 80 to 900mm, formulations can be prepared that are easy and convenient for consumers to mould into a variety of shapes, which, once moulded, will hold their shape exactly during cure without slump or flow.
Plasma motions in the solar loop of emerging magnetic flux

The results of analyzing variations in the line-of-sight (LOS) velocities in the solar loop at photospheric and chromospheric levels in the region of emerging magnetic flux for the evolving active region NOAA 11024 are reported. The analysis combines the data of multiwave spectropolarimetric observations that were carried out on July 4, 2009, (Tenerife, Spain) using THEMIS solar telescope and the data obtained with GOES, SOHO, and STEREO cosmic satellites. A complex sequence of active events has been studied: formation of the Ellerman bomb, B1 X-ray microflare, and four chromospheric surges that were formed as a result of magnetic reconnection caused by new emerging magnetic flux. The Ellerman bomb was formed in the vicinity of a growing pore. Variations in the velocity V
 LOS of the EB had an oscillation character for chromosphere and photosphere. Before the microflare, the average velocities of the upward and downward plasma fluxes in one leg of the magnetic loop were nearly the same—26 km/s. During the microflare, the velocity V
 LOS of the ascending and descending flows increased up to −33 and 50 km/s, respectively. Variations in line-of-sight velocity of a plasma in the second leg of the magnetic loop correlated well with variations of V
 LOS in the region of microflare, but they occurred 1.5 minutes later. During the time of observations, four chromospheric ejections of matter were formed and three of them occurred in the region of Ellerman’s bomb formation. Sharp variations in the soft X-ray intensity occurred during these ejections. At photospheric level, variations in the line-of-sight velocity of plasma in the legs of the loop occurred in the opposite direction. In the region of the first leg, velocity V
 LOS diminished from −1.8 to −0.4 km/s, while the velocity increased from −0.6 to −2.6 km/s in the region of the second leg.
DA PERIFERIA ÀS PERIFERIAS? PELA CRIAÇÃO DE UM NOVO QUADRO ANALÍTICO DOS ESPAÇOS PERIFÉRICOS

Nas últimas décadas, observa-se uma evolução das periferias urbanas, pautada por um processo de complexificação e diversificação socioespacial. Assim, o presente artigo visa discutir o desenvolvimento de um novo quadro analítico na literatura urbana, que ultrapasse a tradicional abordagem binária, focada no antagonismo entre as áreas centrais e as periferias. Realiza-se uma revisão bibliográfica crítica, amparada por exemplos ilustrativos coletados durante trabalho de campo realizado na Região Metropolitana de Belo Horizonte.
TORQUE TRANSMISSION DEVICE WITH AN EPICYCLIC GEAR DEVICE, AND METHOD FOR OPERATING A TORQUE TRANSMISSION DEVICE OF THIS TYPE

The invention relates to a torque transmission device (2), in particular for a motor vehicle with a first drive device (70) and a second drive device (60), wherein the second drive device (60) is configured, in particular, as an electromechanical energy converter, with - an epicyclic gear device (40) with at least one sun gear (42), at least one planetary gear arrangement (43), at least one internal gear (48), and a first input shaft (10), a second input shaft (20) and an output shaft (50), - a first (in particular, switchable) gear device (100), with an idler shaft (30) and a further gear shaft (10), wherein said gear shaft (10) and the first input shaft (10) of the epicyclic gear device (40) coincide, and - a second (in particular, switchable) gear device (200), with a first shaft (61) and a second shaft (20), wherein the first shaft (61) can be connected in a torque-conducting manner to the second drive device (60), and the second shaft (20) coincides with the second input shaft (20) of the epicyclic gear device (40).
Streamflow Simulation by SWAT Using Different Precipitation Sources in Large Arid Basins with Scarce Raingauges

Streamflow from the mountains is the main source of water for the lower plain in arid regions. Accurate simulation of streamflow is of great importance to the arid ecosystem. However, many large arid drainage basins in northwestern China have low density of precipitation stations, which makes the streamflow modeling and prediction very difficult. Based on raingauge data and Tropical Rainfall Measuring Mission (TRMM) data combined with raingauge data, different approaches were explored for spatializing precipitation in large area with scarce raingauges. Spatialized precipitation was then input into Soil and Water Assessment Tool (SWAT), a semi-distributed hydrological model, to simulate streamflow. Results from a case study in the Manas river basin showed that simulated hydrographs using both the approaches are able to reproduce the watershed hydrological behavior. Moreover, statistical assessment indicated that hydrological model driven by the spatialized precipitation based on radar combined with raingauge data performed better than that based on gauge data. Radar precipitation estimator can provide a practical data source for hydrological modeling at a basin scale where the raingauge network is sparse.
Stability of nTiO 2 particles and their attachment to sand: Effects of humic acid at different pH

The fate and transport of nano-scale or micro-scale titanium dioxide particles (nTiO2) in subsurface environments are strongly influenced by the stability of nTiO2 and their attachment to sediment grains. nTiO2 may carry either positive or negative charges in natural water, therefore, environmental factors such as pH, humic substances, and Fe oxyhydroxide coatings on sediment grains, which are known to control the stability and transport of negatively-charged colloids, may influence nTiO2 in different manners. The objective of this study is to investigate the effects of pH and humic acid (HA) on the stability and attachment of nTiO2 to sand at HA concentrations that are relevant to typical groundwater conditions, so that mechanisms that control nTiO2 immobilization and transport in natural systems can be elucidated. Stability and attachment of nTiO2 to quartz sand and Fe oxyhydroxide coated quartz sand are experimentally measured under a range of HA concentrations at pH5 and 9. Results show that at pH5, negatively-charged HA strongly adsorbs to positively-charged nTiO2 and Fe oxyhydroxide, which, at low HA concentrations, partially neutralizes the positive charges on nTiO2 and Fe oxyhydroxide, and therefore decreases the repulsive electrostatic forces between the surfaces, resulting in nTiO2 aggregation and attachment. At high HA concentrations, adsorbed HA reverses the surface charges of nTiO2 and Fe oxyhydroxide, and makes nTiO2 and Fe oxyhydroxide strongly negatively charged, resulting in stable nTiO2 suspension and low nTiO2 attachment. At pH9, HA, nTiO2, and Fe oxyhydroxide are all negatively charged, and HA adsorption is low and does not have a strong impact on the stability and attachment of nTiO2. Overall, this study shows that changes in surface charges of nTiO2 and Fe oxyhydroxide coating caused by HA adsorption is a key factor that influences the stability and attachment of nTiO2.
Smart and inclusive solutions for a better life in urban districts

SMARTER TOGETHER’s overarching vision is to find the right balance between smart technologies and organizational/ governance dimensions in order to deliver smart and inclusive solutions and to improve citizen’s quality of life.
SMARTER TOGETHER gather the European Lighthouse cities Lyon, Munich, Vienna, the Follower cities Santiago de Compostela, Sofia, Venice and Kyiv and Yokohama as observer cities bringing the perspective of East Europe and Asia.  The cities are complemented by business partners from energy, mobility and ICT sectors, leading European research and academia organizations, european city network.  From the various combinations of the different selected Light House areas,  multiples opportunities to learn are offering.
SMARTER TOGETHER delivers 5 clusters of co-created, smart and integrated solutions: (1) Living labs for citizen engagement, (2) District heating and RES for low energy districts, (3) Holistic refurbishment for low energy districts addressing public and private housing, (4) Smart Data management platform and smart services (5) E-mobility solutions for sustainable mobility.
 Expected results are: 1) >151,800 m2 of refurbished buildings, primarily housing estate with a 50-60 % average energy and CO2 reduction; 2) 14.6 MW of newly installed renewable capacity; 3) 10/15new e-mobility solutions for passengers and freight); 4) 1400 created jobs, 130 M€ investments, all deployed with support of integrated ICT solutions and in dialogue with the inhabitants.

Large-scale replication will be prepared; 1) in the Lighthouse cities; 2) the Follower cities, which already selected their target area; 3) A Club of 15-20 cities, associate to intensify its roll-out, ensuring a broad geographical and climate coverage.  Commercial exploitation is enhanced by the development of new business models for widespread use by the stakeholders. Contributions to open data are expected to create business opportunities as well as inputs to standardization work.
Optimization of the Use of Radio Resource of Radio-Over-Fiber Access Networks

In this paper, we introduce a radio resource optimization model for Radio-over-Fiber (RoF) access networks. We propose a mixed integer programming model to minimize the network cost while providing service to all mobile users. The proposed architecture arranges cells in a multi-layer fashion, with cells in each layer providing different coverage radius. The optimization algorithm performs dynamic cell splitting to improve network capacity in congested areas and cell merging in areas with low demand to save resources. The computational demand of the proposed model increases proportionally to the number of layers of RAUs in the infrastructure. Results indicate that two layers of RAUs give the best trade-off between network cost reduction and computational demand.
Development of a design urban bus with a new type of (green) propulsion powered by CNG compressed natural gas

‘Aid programme reference number: Regulation of the Minister of Infrastructure and Development of 10 July 2015 on the granting of financial assistance by the Polish Agency for the Development of Enterprise under the Operational Programme Intelligent Development, 2014-2020 (Dz. U. of 2018, item. 871, as amended), the reference number of the aid programme SA.42799(2015/X)"The object of the project is to carry out a professional design process (PPP) and an initial investment, which will result in a new product – AUTOBUS MIEJSKI powered by CNG, a new style that will be consistent with the design of MODELA MMI and become a guideline for stylistic solutions. The project will be developed on base components (the chassis, powertrain, driving system) and will cover the front, rear, side line and solutions for the driver’s cabin and passenger space, profiling the bus for urban applications. The final result will be a small urban bus with a segment of 7-9 m long, directed to the public sector (community carriers) and private (transport companies). The need to implement the project results from: — the inconsistent design of MMI buses, requiring uniformity for brand identity – outdated, unattractive and non-ergonomic stylistic solutions for the outside and interiors, including unsuitable for urban applications. The above-mentioned difficulties will be eliminated as a result of the implementation of: 1. A PPP comprising: IT’S 1.1. Preliminary diagnosis: feasibility and relevance of the project from the perspective of the applicant’s current situation, human, infrastructure and financial resources. IT’S 1.2. Synthesis and analysis: the aim of this part is to confirm the assumptions made in the diagnosis regarding key needs, including the synthesis of information collected from users (decision makers, drivers, passengers) and in the field of technological solutions, completed with the development of assumptions for the design brief. IT’S 1.3. Development of prototypes and testing of solutions – in III
Early detection of university students with potential difficulties

Abstract Using data mining methods, this paper presents a new means of identifying freshmen's profiles likely to face major difficulties to complete their first academic year. Academic failure is a relevant issue at a time when post-secondary education is ever more critical to economic success. We aim at early detection of potential failure using student data available at registration, i.e. school records and environmental factors, with a view to timely and efficient remediation and/or study reorientation. We adapt three data mining methods, namely random forest, logistic regression and artificial neural network algorithms. We design algorithms to increase the accuracy of the prediction when some classes are of major interest. These algorithms are context independent and can be used in different fields. Real data pertaining to undergraduates at the University of Liege (Belgium), illustrates our methodology.
Viewpoints: A High-Performance High-Dimensional Exploratory Data Analysis Tool

Scientific data sets continue to increase in both size and complexity. In the past, dedicated graphics systems at supercomputing centers were required to visualize large data sets, but as the price of commodity graphics hardware has dropped and its capability has increased, it is now possible, in principle, to view large complex data sets on a single workstation. To do this in practice, an investigator will need software that is written to take advantage of the relevant graphics hardware. The Viewpoints visualization package described herein is an example of such software. Viewpoints is an interactive tool for exploratory visual analysis of large, high-dimensional (multivariate) data. It leverages the capabilities of modern graphics boards (GPUs) to run on a single workstation or laptop. Viewpoints is minimalist: it attempts to do a small set of useful things very well (or at least very quickly) in comparison with similar packages today. Its basic feature set includes linked scatter plots with brushing, dynamic histograms, normalization and outlier detection/removal. Viewpoints was originally designed for astrophysicists, but it has since been used in a variety of fields that range from astronomy, quantum chemistry, fluid dynamics, machine learning, bioinformatics, and finance to information technology server log mining. In this article, we describe the Viewpoints package and show examples of its usage.
Social vulnerability and its intersections: the role of gender in a comparative perspective

VINE seeks to disentangle the multidimensionality of the risk of social exclusion, focusing on vulnerable populations; specifically, those individuals who are in a fragile condition with regard to integration into the domains of well-being (family, labour market, welfare state). Using EU-SILC microdata, the project analyses the interactions between social vulnerability and different individual characteristics that might magnify it. Secondly, the project intends to study how, and in what ways, these individual characteristics combine to determine economic insecurity at household level. The main contribution of this project is proposing an analysis of how the institutional context as well as individual characteristics affects individual risk of living in vulnerable households, from a comparative and multidimensional perspective. By comparing six European countries, as representatives of different institutional environments, the VINE project aims to deliver a better understanding of the causes and mechanisms that determine both men and women’s exposure to social vulnerability. The innovation herein is the assumption that gender is the main analytical dimension in interactions, when theorised according to the intersectional perspective. With a multi-dimensional explorative analysis, and multinomial logistic regression, the analysis will lead to the development of a synthetic indicator of economic insecurity at the household level, permitting assessment of its interactions with specific individual vulnerability profiles. The final aim is to disentangle factors informing individual’s exposure to different degrees of social vulnerability, analysing their consequences and household’s economic insecurity, and possible influences from the institutional context. Thanks to this project, the ER will fill her gap in quantitative research analysis and she will be able to empower her professional profile compete for tenure-track position in the international academic labour market.
DEVICE FOR CONTROLLING THE DISPLACEMENT OF A TOOL ALONG THE EDGE OF GLASS PANES

A device has a horizontal conveyor (1) upon which the glass panes (4) are transported, supported by a supporting device (2) which defines with its supporting front face a glass pane running plane (3), a tool (18) for working on the glass panes (4) along their edges and a drive motor for moving the tool (18) in a direction parallel to the glass pane running plane (3) and transverse to the transport direction (5). In order to control the displacement of the tool (18), electronic line scanning cameras (8) are oriented in relation to the glass pane running plane (3) in such a way that the scanning lines that lie on the glass pane running plane or that are parallel thereto extend in a perpendicular direction to the transport direction (5). In order to measure the conveying distance, a displacement sensor (15) synchronized with the horizontal conveyor (1) is provided. The signals from the line scanning cameras (8) and from the displacement sensor (15) are supplied to an evaluating computer (16) which controls the tool (18).
VEHICLE COMPETITION IMPLEMENTATION SYSTEM

A set of computer executable instructions configured to calculate penalties for a vehicle pilot navigating a competition course which incorporates at least one virtual obstacle, said set of instructions being configured to execute the steps of: a) receiving a vehicle location identifier associated with the present position of the pilots vehicle, and b) comparing the vehicle location identifier with a collision region associated with at least one virtual obstacle of the competition course, and c) assigning at least one penalty to the pilot of the vehicle if the vehicle's location intercepts with the collision region of an obstacle, and d) repeating steps a) through c) as the pilot navigates the competition course and the position of the vehicle changes.