SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Report of 23 cases of choledochal cyst from two hospitals, Mofid and Taleghani in Tehran (1986-2004)

Background: Choledochal cyst is a congenital disorder of biliary tract. It is rare in western but more common in Asian countries. Most studies have been case reports but in this study for assessment of surgical method of treatment and late complications, patients were followed for 18 years. Methods: This retrospective study was done based on 23 patients profiles with diagnosis of choledochal cyst who have been admitted in two hospitals, Mofid and Taleghani in Tehran during 1986-2004. Diagnosis was based on imaging and intraoperative findings variables for assessment were age, sex, cyst type, clinical picture and surgical method of treatment. Results: 70% of cases were female. Type I (sacular and fusiform, 74%) was the most common type, 70% of cases were between 1-5 years old, sonography was the most common imaging technic, that used for diagnosis (100% of cases), Icter was the most common clinical picture found in 70% of cases, surgical procedures and method in 70% of cases was standard and 30% of patients underwent palliative procedures. Conclusion: Although this study shows similarity in age, sex, common type, diagnostic and treatment methods with another centers and countries, but it shows necessity of surgeon’s encouragement to use standard surgical method for decreasing late complications of disease.
The film paintings of David Lynch: challenging film theory

One of the most distinguished filmmakers working today, David is a director whose vision of cinema is firmly rooted in fine art. He was motivated to make his first film as a student because he wanted a painting that 'would really be able to move'. Most existing studies of Lynch, however, fail to engage fully with the complexities of his films' relationship to other art forms. The Film Paintings of David Lynch fills this void, arguing that Lynch's cinematic output needs to be considered within a broad range of cultural references. Aimed at both fans and film studies specialists, Allister Mactaggart addresses Lynch's films from the perspective of the relationship between commercial film, avant-garde art, and cultural theory. Individual works - The Elephant Man, Blue Velvet, Twin Peaks, Lost Highway, The Straight Story, Mulholland Drive, and Inland Empire - are discussed in relation to other films and directors, illustrating that the solitary, or seemingly isolated, experience of film is itself socially, culturally, and politically important. The Film Paintings of David Lynch offers a unique perspective on an influential director, weaving together a range of theoretical approaches to Lynch's films to make exciting new connections among film theory, art history, psychoanalysis, and cinema.
Effects and applications of sub-lethal ultrasound, electroporation and UV radiations in bioprocessing

Advances in bioprocess technology involving microbial cells have led to increased and improved production of beneficial new products and bioactive compounds. However, the semipermeable barrier of the cell membrane often retards the efficient productivity or reaction rate of the cells. Physical treatments such as ultrasound, electroporation and UV radiation provide an efficient approach to increase membrane permeability, leading to enhanced productivity of microbial cells. It is important to note that extensive membrane permeabilization by these physical treatments could be detrimental to cell viability leading to lower yield. An appropriate selection of sublethal dosage and intensity of these physical treatments are critical to preserve the viability of cells and at the same time maintain their bioprocess applications. Despite the promising applications of these physical treatments, safety issues related to possible genotoxicity or mutation of cells upon treatments have been raised. This genotoxic effect of physical treatments could be prevented if appropriate measures are taken, without compromising their bioprocess potentials. The current review highlights the effect of sublethal physical treatments such as ultrasound, electroporation and UV radiation on the viability of cells, their potential bioprocess applications, and the possibility of mutations.
Project to support the maintenance of economic activity of the entrepreneur.

The project concerns support to the entrepreneur in providing liquidity and support to day-to-day activities due to the financial difficulties that have occurred to the entrepreneur as a result of the COVID-19 outbreak. Financial assistance under scheme SA.57015 (2020/N)
Urbanization, Environment and Homelessness in the Developing world: The Sustainable Housing Development.

The problem of homelessness has been necessitated by several factors, including persistent population increases, inadequate housing, and uncontrolled urban growth pattern resulting in “homelessness” among the vast majority of urban dwellers. The need to ensure decent and affordable shelter to the people, particularly the urban poor, is therefore central to the achievement and improvement of both human living standards and societal development (Jiboye, 2011). This paper examined the relevant discussion on Urbanization, Environment and Homelessness in the developing world. Empirically, it determined the numbers of homeless people, Solutions effects and causes of homelessness on people of Ibadan as the challenges of inadequate housing to sustainable housing development in Nigeria. However, it is necessary to have the wider understanding of the homelessness phenomenon as the problem of housing shortage in the developing world. This study was carried out through a survey method using an instrument called questionnaire which was administered to the homeless people in Ibadan. The result of the study justified the need for urgent attention from government and other stakeholders towards addressing the problems of homelessness and inadequate housing among the urban poor and those that are deprived access to decent shelters in the developing world. DOI: 10.5901/mjss.2014.v5n2p261
Guaranteed characterization of exact confidence regions for FIR models under mild assumptions on the noise via interval analysis

SPS is one of the two methods proposed recently by Campi et al. to obtain exact, non-asymptotic confidence regions for parameter estimates under mild assumptions on the noise distribution. It does not require the measurement noise to be Gaussian (or to have any other known distribution for that matter). The numerical characterization of the resulting confidence regions is far from trivial, however, and has only be carried out so far on very low-dimensional problems via methods that could not guarantee their results and could not be extended to large-scale problems because of their intrinsic complexity. The aim of the present paper is to show how interval analysis can contribute to a guaranteed characterization of exact confidence regions in large-scale problems. The application considered is the estimation of the parameters of finite-impulse-response (FIR) models. The structure of the problem makes it possible to define a very efficient specific contractor, allowing the treatement of models with a large number of parameters, as is the rule for FIR models, and thus escaping the curse of dimensionality that often plagues interval methods.
Detection of adverse drug reactions: evaluation of an automatic data processing applied in oncology performed in the French Diagnosis Related Groups database

The aim of this study was to assess an automated detection method of serious adverse reactions induced by oral targeted therapy (OTT) in patients with cancer, performed in the French Diagnosis Related Groups (DRG) database. Patients with cancer of the Poitiers hospital who started an OTT between 2014 and 2015 were included. This study focused on adverse drug reaction which required inpatient hospitalization (ADRh ). All diagnoses coded in the DRG database for hospital stays that occurred within 3 months after OTT initiation were collected (potential ADRh ). Filters (exclusion criteria) were automatically applied on potential ADRh to exclude diagnoses that were not adverse drug reactions (false positives). A pharmacovigilance review was carried out to identify ADRh in the medical records (reported ADRh ). The sensitivity and specificity of the detection method were estimated for each filter combinations by comparison between potential and reported ADRh . This study included 129 patients. The medical records review led to identify 19 ADRh (all coded in the DRG database) in 14 patients. To maintain a 100% sensitivity of the method detection, the best specificity obtained was 58.3% (95% IC: [55.2-61.4]).The use of restrictive filters ('drug' in the diagnostic label, specific diagnosis code for adverse cancer drug reaction) resulted in a 97.8% specificity (95% IC: [96.6-98.5]) with a 38.2% sensitivity (95% IC: [23.9-55.0]). Our method has detected the third of ADRh with an excellent specificity. Complementary experimentations in pharmacovigilance centers are necessary to evaluate the interest of this tool in routine in addition to spontaneous reporting.
Analysis of Total Lung Compliance in Spontaneously Breathing Patients with the Adaptive Time Slice Method

Purpose: To date, few methods have been accepted for clinical use to evaluate the respiratory system compliance (C <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">rs</sub> ) in spontaneously breathing patients at the bedside. The aim of this study was to introduce our adaptive time slice method (ATSM) to continuously calculate the C <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">rs</sub> . Methods: One breathing cycle is divided into several slices along the time axis. For each slice, a least-square-fit based on the first order equation of motion is applied to calculate a slice-specific compliance value C <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">i</sub> and an intercept. The slice width is determined according to the confidence interval of C <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">i</sub> . At the end, after all C <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">i</sub> values are obtained and the outliers are eliminated, the C <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">rs</sub> of this breathing cycle is calculated as the mean value of the C <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">i</sub> . Two spontaneously breathing patients with Chronic Obstructive Pulmonary Disease were included for this preliminary evaluation. The results are compared with the values calculated with the esophageal pressure (P <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">es</sub> ). The compliance measured during controlled mechanical ventilation (CMV) with interrupt technique was used as reference. Results: The intercept calculated with the ATSM can be used to depict the pressure generated by respiratory muscles to some extent. No significant differences in the results were observed between the ATSM method (38.07±3.60 ml/mbar, first patient; 27.71±5.11 ml/mbar, second patient) and the method with P <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">es</sub> (38.20±2.81 ml/mbar, first patient; 27.22±4.71 ml/mbar, second patient), while the compliance values during CMV are 22 ml/mbar (first patient) and 30 ml/mbar (second patient). Conclusions: The ATSM is a robust method and may be able to provide accurate C <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">rs</sub> in spontaneously breathing patients without applying invasive and complicated maneuvers.
DOMESTIC CLOTHS

The invention relates to a domestic cloth for cleaning surfaces. The domestic cloth according to the invention is to be understood as a cleaning cloth, with which surfaces in the home or in the field of gastronomy can be cleaned, and such a cloth is provided with which surfaces in the kitchen area can be cleaned. The problem addressed by the invention is that not just aqueous liquids but also lipid liquids, i.e. oils and grease, are to be absorbed. The invention solves this problem by providing a domestic cloth for cleaning surfaces, consisting of at least three nonwoven fabrics which are arranged one over the other and which are made of reinforced fibers, wherein two outer nonwoven fabrics have a mass per surface unit which is greater than the mass per surface unit of a central nonwoven fabric arranged between the two outer nonwoven fabrics.
Stretchable backpack

A backpack is positioned to rest in an essentially flat configuration between the shoulder blades, so as to mitigate backpack pain or stress. The pack is worn tightly across the individual to eliminate the downward forces of the weight included in a pocket having a rhombus shape. Stretchable material of the pack conforms to the contents of the pack. Effectively, the weight of the pack is distributed across the chest and back of an individual to provide a “weightless effect”.
Directed evolution of enzyme for applied biocatalysis at ultrahigh throughput in picoliter droplets

Enzymes have established as a new class of catalysts in the field of modern synthetic chemistry and continue to gain in importance. Directed evolution is currently one of the most promising approaches aiming at enzymes with desired catalytic activities and it's potentially directly correlates with the library size that can be screened. One of the most powerful approaches to overcome these limitations is arguable the recently introduced microfluidic droplet technology; this methodology not only allows to quickly screen millions of clones in a cost effective manner, but is also broadly applicable since fluorometric as well as colorimetric assays can be used. Interestingly, even though numerous publication highlight its potential, an unambiguous evidence of its ability to provide synthetically relevant biocatalysts still needs to be furnished. In addition, access to this technology is currently limited to a few academic research groups and thus, this approach requires further implementation to evolve as an easily manageable lab routine in the near future. 
This project is designed to unite three competencies: i) the expertise of the Hollfelder Group in regarding micro-engineering and protein engineering in droplets, ii) the empirical knowledge of (bio)chemists at Johnson Matthey in view of economically successful industrial applications of biocatalysts and iii) the strong track record of the experienced researched to successfully solve problems at the biology/chemistry-interface. The objective of the project is to perform a proof-of-principle study by improving a well-known alcohol dehydrogenase for the selective desymmetrization of a meso-diol, thereby giving access to a synthetically sophisticated alcohol. In addition, the final aim is not only to obtain an improved mutant which allows to perform the selected biotransformation efficiently, but also a comparison of varying evolution paths differing in the criteria of hit selection between mutagenesis rounds.
Azione, prassi, storia

Il presente articolo esplora il significato del concetto di “istituzione”, prestando particolare attenzione all’esposizione che Merleau-Ponty ne dà nelle pagine del corso tenuto al Collège de France nel 1954-1955, L’institution, la passivité. Il saggio mira a mostrare come, attraverso tale nozione, sia possibile pensare una concezione dell’agire, della prassi e quindi della storia che connette il lato attivo e passivo del fare. Il contributo prende le mosse da un’analisi delle critiche che Merleau-Ponty rivolge a Sartre nel corso de Le avventure della dialettica, per mostrare il bersaglio polemico al quale si rivolge la concezione dell’azione sviluppata nel corso sull’istituzione. Dopodiché, prende in considerazione più da vicino l’articolazione del tema nel corso sull’istituzione. Infine, cerca di descrivere la concezione della storia che emerge da tale plesso concettuale. In conclusione, il contributo propone un’apertura del problema dell’istituzione a problemi della contemporaneità, come quello dell’agency.
Occupational noise-induced hearing loss of workers in a bauxite mine in India

Noise exposure from workplace can cause occupational noise-induced hearing loss (ONIHL) which begins at higher frequencies and gradually extends to lower frequencies. The aim of this study was to investigate the ONIHL among a highly mechanized bauxite mine employees from Odisha, India and to identify the possible determinants of ONIHL. A total of 247 personnel were tested for hearing loss at various frequencies (500, 1000, 2000, 3000, 4000, 6000 and 8000 Hz) using PC-based digital audiometer between April 2014 and December 2015. Statistical analysis was conducted using SYSTAT 13.0. The study revealed that the industrial noise level exceeded the permissible limit during the operational hours and is likely to cause noise-induced hearing loss. Audiometric results reveal that a total of 85 out of 247 (34% )workers were found to have ONIHL in the age group of 28 to 63 years; from these, 43 of 57 (75%) work as operators followed by 27 of 58 (47%) charge-man, 12 of 92 (13%) technicians and 3 of 24 (12%) foreman. Study indicated a significant relation between occupation, industrial noise levels and duration of exposure in development of ONIHL among miners.
AUTOMATIC FLUSH VALVE ACTUATION APPARATUS

A flexible drive mechanism for a flushing apparatus actuated by movement of a flush handle (30) via an actuation element (60) is disclosed. The drive mechanism includes a housing (40) and flexible drive system in the housing (40), the flexible drive system including an actuating element (60) operable to move the flush handle (30) between a non-actuating position and a full stop actuating position. The housing (40) further includes first and second bracket halves (74, 80) and first and second removable insert halves (274, 280)for adapting the first and second bracket halbes to substantially enclose and engage a bushing (44) and nut (46) and thereby secure said electromechanical flexible actuator to the flush lever of the sanitary fixture.
Almost Isoperimetric Subsets of the Discrete Cube

We show that a set A ⊂ {0, 1} n with edge-boundary of size at most can be made into a subcube by at most (2ε/log 2 (1/ε))| A | additions and deletions, provided ε is less than an absolute constant. We deduce that if A ⊂ {0, 1} n has size 2 t for some t ∈ ℕ, and cannot be made into a subcube by fewer than δ| A | additions and deletions, then its edge-boundary has size at least provided δ is less than an absolute constant. This is sharp whenever δ = 1/2 j for some j ∈ {1, 2, . . ., t }.
Reducing barriers and increasing uptake of text and data mining for research environments using a collaborative knowledge and open information approach

The exponential growth of data in the digital age has led to the development of powerful techniques for effectively harnessing digital information and discovering new knowledge. In this context, Text and Data Mining (TDM) enables researchers from different disciplines to analyse, extract insights and knowledge, and exploit diverse and complex datasets from various digital media. However, the present use of TDM in Europe is significantly lower than in the US and Asia, most probably due to limitations imposed by the European legal framework. In this light, the FutureTDM project identifies and reduces the barriers that inhibit the uptake of TDM for researchers, and innovative businesses. FutureTDM provides critical up-to-date assessments of legal regulations and policies impacting TDM in the EU, and places them in the international research and innovation context. It adopts a bottom-up approach by initiating dialogue between all relevant stakeholders, engaging them via knowledge cafés, workshops and representation on the advisory board to help identify barriers, common solutions and increase awareness of TDM practices and their potential. This combined approach will lead to developing novel policy frameworks and interdisciplinary case-driven practitioner guidelines facilitating the spread of TDM activities. Key to success will be the engagement of actors in the broader community (libraries, publishers, funders, etc.), who will be mobilised through workshops and will be provided with targeted recommendations in the Roadmap for TDM’s uptake. The knowledge distilled from quantitative and qualitative research will be integrated into a Collaborative Knowledge Base and Open Information Hub (www.FutureTDM.eu) using insightful visualisations. This dynamic platform will showcase excellence in TDM research and data-driven innovation and serve as reference for current and future TDM practitioners ensuring broader TDM uptake to boost Europe’s research and innovation capacities.
Silicone composition for release paper or release film, and release paper and release film

A compound that is devoid of epoxy groups and has a quantity of alkenyl groups corresponding to 5-1000 times the alkenyl group content of a base polymer, and/or an organopolysiloxane that is devoid of alkenyl groups, has an average degree of polymerization of 2-50, and contains, per molecule, 30 mol% or more of siloxane units having epoxycyclohexyl groups bonded to silicon atoms via carbon atoms, are/is blended with a silicone composition for a release film as adhesion-enhancing components.
Atlas of the clinical genetics of human dilated cardiomyopathy

Numerous genes are known to cause dilated cardiomyopathy (DCM). However, until now technological limitations have hindered elucidation of the contribution of all clinically relevant disease genes to DCM phenotypes in larger cohorts. We now utilized next-generation sequencing to overcome these limitations and screened all DCM disease genes in a large cohort.In this multi-centre, multi-national study, we have enrolled 639 patients with sporadic or familial DCM. To all samples, we applied a standardized protocol for ultra-high coverage next-generation sequencing of 84 genes, leading to 99.1% coverage of the target region with at least 50-fold and a mean read depth of 2415. In this well characterized cohort, we find the highest number of known cardiomyopathy mutations in plakophilin-2, myosin-binding protein C-3, and desmoplakin. When we include yet unknown but predicted disease variants, we find titin, plakophilin-2, myosin-binding protein-C 3, desmoplakin, ryanodine receptor 2, desmocollin-2, desmoglein-2, and SCN5A variants among the most commonly mutated genes. The overlap between DCM, hypertrophic cardiomyopathy (HCM), and channelopathy causing mutations is considerably high. Of note, we find that >38% of patients have compound or combined mutations and 12.8% have three or even more mutations. When comparing patients recruited in the eight participating European countries we find remarkably little differences in mutation frequencies and affected genes.This is to our knowledge, the first study that comprehensively investigated the genetics of DCM in a large-scale cohort and across a broad gene panel of the known DCM genes. Our results underline the high analytical quality and feasibility of Next-Generation Sequencing in clinical genetic diagnostics and provide a sound database of the genetic causes of DCM.