SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Bilateral caudate nucleus infarction resulting from left ventricular diastolic dysfunction

Abstract Bilateral caudate infarct is a very rare neurological situation, usually caused by small-artery disease resulting from a cardiac embolism. The most prominent clinical features of caudate vascular lesions are behavioral and cognitive abnormalities. We report here a case of bilateral infarction of the caudate nucleus and right parietal lobe with loss of consciousness and left hemiparesia resulting from left ventricular diastolic dysfunction (LVDD). A 50-year-old woman was admitted to our clinic with symptoms of mental status change. One day ago before appearing at our clinic, the patient was hospitalized because of food intoxication and diarrhea. Her neurological examination revealed that orientation-cooperation was impaired, and motor weakness was found in the left extremities, predominantly in the upper limb. The lesions detected by CT and MRI were located on the bilateral caudate nucleus and right parietal lobe. Transthoracic echocardiography revealed LVDD. Therefore, the patient was diagnosed as having had an ischemic stroke. Three days after the treatment, all neurological deficits had improved and the patient was discharged. Attending physicians should be alert to the presence of permanent or intermittent complications of LVDD in patients with ischemic cerebral events, especially in patients with the bilateral caudate nucleus infarcts.
Benefit–Risk Assessment of Vaccines. Part I: A Systematic Review to Identify and Describe Studies About Quantitative Benefit–Risk Models Applied to Vaccines

Understanding the balance between the benefits and risks of vaccination is essential to ensure informed and adequate public health decision making. Quantitative benefit–risk models (qBRm) represent useful tools to help decision makers with supporting benefit–risk assessment throughout the lifecycle of a medical product. However, few initiatives have been launched to harmonise qBRm approaches, specifically for vaccines. The aim of this paper was to identify publications about qBRm applied to vaccines through a systematic literature review, and to describe their characteristics. Medline, Scopus and Institute for Scientific Information Web of Knowledge databases were searched to identify articles in English, published from database inceptions up to December 2019. The search strategy included the combination of three key concepts: ‘benefit–risk’, ‘modelling’ and ‘vaccines’. Data extracted included the modelling context and the methodological approaches used. Of 3172 publications screened, 48 original publications were included. Most of the selected studies were published over the past decade and focused on rotavirus (15), dengue (10) and influenza (6) vaccines. The majority (30) of studies reported analyses related to high-income countries. The methodology of the studies differed, particularly in modelling techniques, benefit–risk measures, and sensitivity analyses. The present work also pointed out a high level of variability in the quality of reporting across studies, with particular regard to input parameters and methodological approaches. This review provides an extensive list of qBRm applied to vaccines. Discrepancies across studies were identified during our review. While the number of published qBRm studies is increasing, no reporting guidance for qBRm applied to vaccines is currently available. This may affect decision makers’ confidence in the results and their benefit–risk assessment(s); therefore, the development of such reporting guidance is highly needed.
Achieving Research-Informed Practice Amongst Teachers in Madrid and Catalonia: Findings From a Quantitative Analysis

Background: In Spain, as in many other countries, educational administrators are calling for schools and teachers to engage with research-informed teaching (RIT) to improve the quality of teaching and student outcomes. Despite this interest, schools’ and teachers’ engagement with research evidence is inconsistent, and studies exploring the factors affecting teachers’ and schools’ commitment to RIT, in the Spanish context, are undeveloped.Analysis: The authors analyzed a survey sample of 462 teachers in 204 Spanish schools to identify teacher and school characteristics that determine teachers’ likelihood of engaging in evidence-informed educational practice (EIP). This analysis explores variables such as teachers’ concepts of research, their self-efficacy to understand and conduct educational research, and the influence of school organizational variables.Findings: Teachers seem reluctant to use research in class practice. Whether research is seen as relevant to their immediate or short-term needs, combined with the capacity to use data research evidence, appears to be a decisive factor for those engagedwith research. Résumé Contexte : En Espagne, comme dans plusieurs autres pays, les administrateurs scolaires demandent aux écoles et aux enseignants de s’inspirer de l’enseignement fondé sur la recherche afin d’améliorer la qualité de l’enseignement et les résultats des élèves. Malgré cette demande, l’engagement des écoles et des enseignants à l’égard des résultats de recherche n’est pas des plus forts. D’autre part, dans le contexte espagnol, les études explorant les facteurs qui influent sur l’engagement des enseignants et des écoles envers l’enseignement fondé sur la recherche sont peu développées.Analyse : Les auteurs ont analysé un échantillon d’enquête de 462 enseignants dans 204 écoles espagnoles pour identifier les caractéristiques des écoles et des enseignants qui déterminent la probabilité que ceux-ci s’engagent dans l’éducation fondée sur les preuves (EFP). Dans leur analyse, les auteurs explorent des variables telles que la manière dont les enseignants perçoivent la recherche, l’efficacité de ces derniers à comprendre et à mener la recherche en éducation, et l’organisation de l’école.Conclusion : En général, les enseignants semblent réticents à recourir à la recherche dans leurs salles de classe. Pour ceux qui le font, le fait qu’ils la considèrent comme pertinente pour leurs besoins immédiats ou à court terme ainsi que leur habileté à utiliser des données issues de la recherche semblent être des facteurs décisifs. Keywords / Mots clés : research-informed teaching, evidence-informed educational practice, educational research / enseignement fondé sur la recherche, éducation fondée sur les preuves, recherche en éducation
Toxic expertise: environmental justice and the global petrochemical industry

This research project critically examines ‘toxic expertise’, the contested politics of making scientific claims about the health impacts of toxic pollution. Toxic expertise has a double meaning: scientific expertise about the effects of toxic pollution, and the toxic nature of expertise that is used to justify a lack of corporate social responsibility. The research focuses on the global petrochemical industry as a significant but controversial source of toxic pollution, with unequal regulations and risks across different countries and populations. Debates about the global petrochemical industry reflect conflicting interests between jobs, prosperity, and health. This research contributes to interdisciplinary social scientific research on science and technology, environmental justice movements, and the uneven geography of capitalism. In particular, it develops sociological arguments that scientific ‘expertise’ is inherently political and socially constructed. This mixed method comparative research will be conducted in three stages. The first stage will examine toxic expertise in the leading global petrochemical companies and environmental non-governmental organisations in Western Europe, North America, and China. The second stage will focus on in-depth case studies in the United States and China, two of the top petrochemical producers in the world. The third stage will develop an international public resource of toxic expertise to address practical challenges of capacity and scale inherent within both dominant and citizen-led epidemiology, by developing accessible information and tools for understanding, monitoring, and reporting toxic pollutants and their health impacts. The project offers the first systematic sociological analysis of the global petrochemical industry in relation to environmental justice, responding to calls within critical social science for the democratisation of science which highlight the need for greater accountability and transparency.
Research progress in biological basis of cold and heat essence of Chinese medicine

Cold-heat problem is one core of traditional Chinese medicine theory. This paper summarizes the experimental research related to the biological basis of cold-heat essence in cold-heat syndrome, cold-heat body constitution and cold-heat property of Chinese herbs. In view of the classical physiological and biochemical indices, gene expression, protein expression and metabolic differences, differences in cold-heat syndrome or cold-heat constitution are mainly based on neurotransmitter, thyroid function, sex hormone, cyclic nucleotide system, and energy metabolism relating to the corresponding gene and protein expression. Furthermore, this paper analyses the change of correlation indices that accompany with a dynamic development process of "constitution-syndrome-herbal intervention", implying that the research of biological basis of cold-heat essence has turned from single index to multiple indices, and from dispersion research to system research.
A functional, mature in vivo human ventricular muscle patch for cardiomyopathy

Developing new therapeutic strategies for heart regeneration is a major goal for cardiac biology and medicine. While cardiomyocytes can be generated from human pluripotent stem (hPSC) cells in vitro, it has proven difficult to use these cells to generate a large scale, mature human heart ventricular muscle graft on the injured heart in vivo. The central objective of this proposal is to optimize the generation of a large-scale pure, fully functional human ventricular muscle patch in vivo through the self-assembly of purified human ventricular progenitors and the localized expression of defined paracrine factors that drive their expansion, differentiation, vascularization, matrix formation, and maturation. Recently, we have found that purified hPSC-derived ventricular progenitors (HVPs) can self-assemble in vivo on the epicardial surface into a 3D vascularized, and functional ventricular patch with its own extracellular matrix via a cell autonomous pathway. A two-step protocol and FACS purification of HVP receptors can generate billions of pure HVPs- The current proposal will lead to the identification of defined paracrine pathways to enhance the survival, grafting/implantation, expansion, differentiation, matrix formation, vascularization and maturation of the graft in vivo. We will captalize on our unique HVP system and our novel modRNA technology to deliver therapeutic strategies by using the in vivo human ventricular muscle to model in vivo arrhythmogenic cardiomyopathy, and optimize the ability of the graft to compensate for the massive loss of functional muscle during ischemic cardiomyopathy and post-myocardial infarction. The studies will lead to new in vivo chimeric models of human cardiac disease and an experimental paradigm to optimize organ-on-organ cardiac tissue engineers of an in vivo, functional mature ventricular patch for cardiomyopathy
The amount of nitrogen applied and nutritional status of olive plants affect nitrogen uptake efficiency

Abstract Mist-rooted ‘Picual’ olive cuttings were used to test the hypothesis that both the amount of nitrogen applied and the nutritional status of olive plants may affect nitrogen uptake efficiency (NUE). Plants were placed in a greenhouse at 30/15 °C (day/night) with a 14 h photoperiod. Two different experiments were developed. In the first, plants were subjected to the application of 0, 50, 100, 200, 400, 600 or 800 ppm N. In the second experiment, the aim was to obtain three groups of plants differentiated by the nutritional status. Each group received 0, 50 or 100 ppm N, according to the results obtained in the first experiment. When plants of each group differed in their nitrogen content, they were subjected to additional nitrogen application either via foliar or to the soil. At the end of each experiment, plants were harvested and nitrogen was determined in leaves, stems and roots to obtain the nitrogen uptake by the plants. Nitrogen uptake efficiency (NUE) was estimated as NUE = (N uptake/N applied) × 100. Nitrogen content of the plant, vegetative growth and leaf chlorophyll content increased from 0 to 100 ppm N applied, decreasing at higher doses of N application. Consequently, NUE exponentially decreases with the amount of N applied above 100 ppm, with values ranging from 45.9% at 100 ppm to 4.1% at 800 ppm N. The method of nitrogen application, foliar or to the soil, does not affect nitrogen uptake, but the contrary occurs with the nutritional status of the plant. Nitrogen deficient plants were able to uptake more fertilizer nitrogen that well-nourished plants, with a significant reduction in NUE. Consequently systematic, annual applications of large amounts of fertilizer nitrogen may cause nitrogen over-fertilization and negative effects in both the plant and the environment.
Community practitioners supporting young men with borderline intellectual functioning in the criminal justice system: capability for voice and agency

This article is based on findings from a recent study of community practitioners working in re-entry and reintegration support services in South East Queensland, Australia, which examined the role and influence of these practitioners on young men with mild intellectual impairment or borderline intellectual functioning who were involved in the criminal justice system. The article reflects upon practitioners’ agentic influence and capability for voice across the community services sectors and proposes the extent to which practitioners believed this affected the options available to vulnerable young men with borderline intellectual functioning in the community. The article draws on data collected from the qualitative study, which included interviews with community practitioners and observations of practitioner–client sessions. These data were analysed using a grounded theory approach. The analytical strategy applied Sen’s capability framework within which to interpret the capabilities of practitioners. Practitioners were drawn from funded community organisations providing offender reintegration services, a homelessness service, and a volunteer community group working with ex-prisoners. Findings suggest that reintegration of vulnerable young men with borderline intellectual functioning requires community practitioners to exercise capability for voice and agency in ways that build relational environments. Interaction between re-entry and reintegration services and the broader community services sector can create practical opportunities for support within the reach of young men with borderline intellectual functioning towards community reintegration.
Analysis of Urban Network Characteristics from Perspective of Sina Microblog——With Main City of Chongqing as an Example

Urban spatial structure has been subject to wide attention of scholars from all walks of life.Especially in an era of rapid development of information and technology,urban spatial structure has changed tremendously.With Sina microblog as a starting point,the main city of Chongqing city network structure characteristics have been studied.Urban network from the study shows that there are obvious hierarchical relationships according to the Sina microblog statistics based on the different specific gravity level,between the districts of Chongqing:the calculated correlation degree and connectivity between the various regions of the city level showsrelative consistency,while showing slightly different from the conventional level.It provides a fast and efficient analysis and decision-making reference standard for future urban planning department.
Distance measuring device laser light source - has optics emitting light beam in measuring range optics projecting reflected light onto detector

The device for measuring distances has a laser light source with a first optical system with which a laser beam is emitted in the direction of a measuring range. There is also a positionally sensitive light detector and a second optical system with which light, reflected by an object in the range, is projected onto the detector. A supply circuit excites the laser source and is controlled by a signal which can vary the intensity of the emitted light rays within predetermined limits. The detector is connected to an intensity detecting circuit producing an output signal whose strength is related to the intensity. This light intensity dependent signal is compared in a threshold value circuit, to stimulate the supply circuit. Thus with an intensity dependent signal over the threshold value, the laser source provides a relatively high power for measuring purposes.
Summation through stochastic drawing of addends under steered morphing

A stochastic methodology for the numerical estimation of sums over a very large number of addends with huge spread of magnitudes is presented as continuation of our recent work in the field of multidimensional integration. The approach is based on the employment of Jarzynski’s equality, borrowed from the physical context of thermodynamics of small systems (mainly macromolecular) subjected to driven transformations while all uncontrolled degrees of freedom freely fluctuate. An abstract interpretation of such an equality enables us to convert the sum into an exponential average over the “computational work” required to morph the addends from an initial set of values (taken all equal for simplicity) up to their actual values while the summation indexes are stochastically sampled by means of Importance Sampling Monte Carlo moves. A series of numerical tests reveals the high efficiency of the method in performing summations otherwise unfeasible. • A tool for stochastic evaluation of nested sums with many indexes is proposed. • The Jarzynski equality is borrowed from the context of molecular thermodynamics. • Addends build-up is seen as homologous of driven transformations in real systems. • Numerical tests demonstrate the high performance of the method.
RURAL DEVELOPMENT PLAYERS

Ruraland is the result of a high level of understanding between a series of European regions which have a long-standing tradition in cooperation between each other and with other territories. Ruraland was set up after various meetings with different entities sharing the wish to promote innovative and competitive regional rural development policies. The partnership is made up by 10 regional authorities at a Nuts II level or equivalent, from 9 countries (Belgium, Bulgaria, Spain, Finland, France, Italy, Portugal, Romania and Sweden), which, as a group, make up a very balanced representation of the current EU_x000D_
Behind this link between the regions, (the desire to promote said policies), the project main objective could not be any other than “reinforce efficiency and innovation in regional rural development policies which have the economic diversification of the rural areas as their objective by means of regional cooperation as a means towards reaching a greater degree of cohesion & balance_x000D_
between the European regions”._x000D_
In order to reach this objective, a methodological base has been defined, which, apart from including the activities that are traditionally carried out in cooperation processes (seminars, studies, web site, etc.), include activities and tasks related to the transfer of experiences in 4 key areas in rural development: Economic competitiveness, new technology and renewable energy; new employment, ITCs and services to the population; natural and cultural economic valorisation. The good practices will be transferred reinforcing the network established by the project, as one same experience will be transferred by various partners at the same time, always guaranteeing trans-nationality_x000D_
In addition, activities addressed to the carrying out of a reflection and agreement task that contribute to the direct influence on the rural development regional policies by means of the drafting of regional policy recommendations and a Joint European Policy Recommendation_x000D_
are contemplated. The result of these activities will generate outputs such as thematic seminars, database for capitalised good practices, visits to the territories in order to see the experiences in situ, feasibility studies to assess and adapt the experience to the territory receiving them, publications with conclusions and results in each one of the thematic areas, a final publication, and policy recommendations for rural development policies of the participant regions. _x000D_
Regarding the results produced, the exchange of experiences will become a permanent acquisition for the regions as a whole, these results being immaterial and collective given their nature. The result of the reflection work will strengthen the dialogue and agreement capacity of the authorities from the regions, as well as the relationships between the regions in the future. The publications, publicity and material published will be permanent and will stimulate the dissemination of the results in the long term
Improved production of low cost silver nanowires

In the development of new smart phones and tablets, there is a market requirement for alternatives to transparent conductive films (TCF) based on indium tin oxide (ITO). For ITO, the combination of conductive and optical properties is not good enough for many new products, and additionally ITO is brittle and can crack when repeatedly flexed in a touch panel.
The leading contender for replacing ITO in TCF is silver nanowires and NANOGAP is the leading European manufacturer of nanowires. With a unique patented technology and resultant freedom to operate, NANOGAP has an excellent competive position in a growing market
Based on NANOGAP’s technology and freedom to operate NANOGAP has commercial contracts in place with two global companies. In order grow the customer base and sustain this business opportunity NANOGAP must further enhance its technology, improving product performance to levels demanded by the industry (lower sheet resistance, higher light transmission, lower haze) while lowering costs. This project addresses these requirements by using new methods to both study and optimise the synthesis reaction and through developing new improved post-synthesis purification methods. Additionally, during the feasibility phase of this project, a market study will be performed on verifying new market opportunities for the new improved low cost products arising from this project. The key technical innovations will be around real time monitoring of very sensitive reaction conditions coupled to real time kinetic modelling. It is envisaged that this technique will form the basis of future in-line quality control procedures. Also, very importantly, new cross flow filtration techniques will be assessed for post-synthesis purification with particular interest in bespoke membrane development. The expected results from the technical innovation will be thinner longer nanowires, produced at higher purity and lower cost. This will translate to meeting the customer demands