SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Co-Modal journey re-accommodation on associated travel services

Conceptually, the CO-ACTIVE project addresses the general enrichment of the ‘one-stop-shop’ capability as initiated in the IT2Rail project and further completes the scope of functionality by addressing post-sale business transactions, and an underlying payment-settlement solution for comodally retailed products and services. This provides the opportunity to focus specifically on those aspects of comodality whose level of customer-perceived risk discourages the advance purchase of comodal travel entitlements:

·         Enhancing the technical facilitation of a one-stop-shop capability, to enable comprehensive choice of offers from modes/operators able to respond to customer mobility queries, especially through the data structuration.

·         Research into the different possibilities for managing retailer-TSP settlement in order to simplify/rationalise integration, for retailers, of today’s multiple (mode/operator) settlement system infrastructures which itself represents a constraint for the funnelling of multiple-TSP content to 3rd party retailer outlets; this includes demonstration of a retailer ‘merchant’ model/approach.

·         Analysis of potential automation and orchestration (where identified by research) based on the information of previously generated travel entitlements, for the purposes of enabling the processing of cancellations, ticket exchanges and refunds in accordance with TSP business rules and revenue management policies, as well as in accordance with the needs of the customer when Trip Tracker determines that re-accommodation services are required to ensure arrival at final destination.
Design of portable warehouse management system based on wireless sensor technology

A portable storage management system which includes control terminal and management unit is designed.The management unit which realizes high precision weighting can be used to goods classification and storage management.Control terminal is designed to portable module that can read management unit parameters and the goods inventory real-time,to remind the logistics and achieve warehouse management.The two parts communicate with each other through wireless communication style,mean while control terminal has the network capabilities,which helps users to control remotely.Compared with the traditional warehouse management,the system can achieve real-time monitoring,costs saving and reduction of errors.This system has a good prospect in the management of valuable mechanical parts.
Osteogenesis of human adipose-derived stem cells on poly(dopamine)-coated electrospun poly(lactic acid) fiber mats

Electrospinning is a versatile technique to generate large quantities of micro- or nano-fibers from a wide variety of shapes and sizes of polymer. The aim of this study is to develop functionalized electrospun nano-fibers and use a mussel-inspired surface coating to regulate adhesion, proliferation and differentiation of human adipose-derived stem cells (hADSCs). We prepared poly(lactic acid) (PLA) fibers coated with polydopamine (PDA). The morphology, chemical composition, and surface properties of PDA/PLA were characterized by SEM and XPS. PDA/PLA modulated hADSCs' responses in several ways. Firstly, adhesion and proliferation of hADSCs cultured on PDA/PLA were significantly enhanced relative to those on PLA. Increased focal adhesion kinase (FAK) and collagen I levels and enhanced cell attachment and cell cycle progression were observed upon an increase in PDA content. In addition, the ALP activity and osteocalcin of hADSCs cultured on PDA/PLA were significantly higher than seen in those cultured on a pure PLA mat. Moreover, hADSCs cultured on PDA/PLA showed up-regulation of the ang-1 and vWF proteins associated with angiogenesis differentiation. Our results demonstrate that the bio-inspired coating synthetic degradable PLA polymer can be used as a simple technique to render the surfaces of synthetic biodegradable fibers, thus enabling them to direct the specific responses of hADSCs.
STUDIO MANES EMPRESA ENTRE PROFISSIONAIS EM PARCERIA SIMPLES

O ESTUDO MANES S.T.P. É UM CONSULTÓRIO DENTÁRIO QUE TRATA DE SERVIÇOS ODONTOLÓGICOS E, EM ESPECIAL, DE: ORTODONTIA INTERCETADA PRECOCEMENTE, ORTODONTIA FIXA PARA ADULTOS, ORTODONTIA COM SISTEMAS INVISÍVEIS, GNATOLOGIA, CONSERVAÇÃO E PRÓTESES ADESIVAS, IMPLANTES EM IMPLANTES, ENDODONTIA, HIGIENE DENTÁRIA E PREVENÇÃO, PROTESIADESIVA E EM IMPLANTES, CIRURGIA ORAL, IMPLANTOLOGIA, CIRURGIA PERIODONTAL, CIRURGIA PERIODONTAL, HIGIENE E PREVENÇÃO DENTÁRIA, TERAPIA DE MANUTENÇÃO PARODONTAL.
IMPROVED CONTAINER AND LID ASSEMBLY

A plastic container (50) and lid (100) assembly for storing liquid coating materials. The container (50) has a body (51) with a bottom wall (52), at least four sidewalls (54) and a neck. The neck defines a wide mouth opening and including threads (66) for receiving mating threads on the lid (100). The lid (100) also has a plurality of lugs, extending radially from the lid and terminating at or before the lugs extend beyond the container sidewalls when the lid is in sealed engagement with the container (50). The body also has an integral handle (84) for lifting the container and the container neck supports a bail-type handle (120) also for lifting the container (150). The integral handle (84) and bail-type handles (120) do not extend beyond the container sidewall. The contianer (50) and lid (100) have an effective packing footprint and an effective packing volume substantially conforms to the effective packing footprint and the effective parking volume of a conventional metal paint can.
Kilonovarank: gravitational wave counterparts and exotic transients with next-generation surveys

Time-domain astronomy will soon be transformed by powerful instrumentation: the Large Synoptic Survey Telescope (LSST) and upgraded gravitational wave detectors. We will finally be able to build large samples of rare and multi-messenger transients, allowing new scientific breakthroughs. But to do so, we must overcome the substantial difficulty of identifying the important events among an expected sea of contaminants. I will solve this problem by developing novel image classification techniques before LSST begins, and then use this with LSST data to answer some of the most pressing questions about stellar evolution, nucleosynthesis, and high energy physics. I will discover hundreds of superluminous supernovae (SLSNe), key to unknown physics in massive stars, and tidal disruption events (TDEs) of stars around supermassive black holes, probing black hole accretion in usually inaccessible regimes. By folding in the sky maps from GW detections of neutron star mergers, I will rapidly find kilonova counterparts in LSST follow-up searches. With 10-100 kilonovae (compared to 1 well-studied event now), we will understand the nucleosynthesis of all heavy (r-process) elements, determine the equation of state for nuclear matter, and pin down what these mergers leave behind. Moreover, I will determine the progenitor stars and power source of SLSNe, and the emission mechanisms in TDEs and relation to black hole mass, using even larger samples of those events. We may even find whole new transient classes. This project could not be more timely as the upgrades in GW detectors, the start of LSST, and the brief era of JWST will overlap in just a few years (and within the time of an ERC-funded project). Everything is in place for success, from guaranteed data access and follow-up resources, to public/prototype codes. The legacy datasets for rare transient classes will dwarf those from pre-LSST, and our inference framework will lead to an unprecedented understanding of these populations.
Mechanical analysis of the influence of the change in the height of gravitational center on body sway properties for postural control in the human body

To mechanically elucidate the influence of the difference in the height of gravitational center on postural balance, we analyzed the body sway while standing in both young and elderly subjects. Body sway of young subjects was evaluated with and without weights of 50 N attached to the knees and shoulder regions respectively. Although the body sway was not influenced by the difference in the height of gravitational center in young subjects, it increased significantly when loaded with weights. In elderly subjects, however, it became clear that the body sway was affected by the height of gravitational center even without any load.
DNA EXPRESSION VECTORS

The invention relates to DNA vectors containing a transcription regulatory sequence derived from Human Cytomegalovirus major immediate early gene that includes exon 1, but not intron A. Vectors, host cells, pharmaceutical and vaccine compositions comprising such host cells and vectors are contemplated.
Esportazione globale CW

Comporta Wines realizzerà questo progetto di internazionalizzazione con l'obiettivo di incorporare strumenti innovativi per esplorare nuovi Paesi strategici, oltre a consolidare altri già esplorati, con l'obiettivo di crescere nel mercato globale e mitigare le dipendenze delle economie tradizionali.
PROCESS OF CHLORINE DIOXIDE BLEACHING OF CHEMICAL PULPS USING MAGNESIUM HYDROXIDE OR MAGNESIUM OXIDE

The present invention provides an improved process for chlorine dioxide bleaching of chemical pulps in an aqueous suspension, which uses magnesium hydroxide or magnesium oxide. The process involves the addition of magnesium hydroxide or magnesium oxide to the pulp, in addition to chlorine dioxide, maintaining the mixture at a pH between about 2.5 to 7.5 for about 1 or more hours, most suitably between about 1 - 4 hours. This process can be used in the D1 or D2 stage of a typical D0EopD1E2D2 bleaching sequence, as well as in the chlorine dioxide brightening stage of other three, four, five, and six-stage bleaching sequences of either the so-called ECF process, or those containing elemental chlorine (Cl2). The temperature is between about 40 to about 90°C, and the pulp consistency is between about 1 to about 16%.
Mitochondrial myopathy, lactic acidosis, and sideroblastic anemia (MLASA) plus associated with a novel de novo mutation (m.8969G>A) in the mitochondrial encoded ATP6 gene

Mitochondrial myopathy, lactic acidosis and sideroblastic anemia (MLASA) is a rare mitochondrial disorder that has previously been associated with mutations in PUS1 and YARS2. In the present report, we describe a 6-year old male with an MLASA plus phenotype. This patient had features of MLASA in the setting of developmental delay, sensorineural hearing loss, epilepsy, agenesis of the corpus callosum, failure to thrive, and stroke-like episodes. Sequencing of the mitochondrial genome identified a novel de novo, heteroplasmic mutation in the mitochondrial DNA (mtDNA) encoded ATP6 gene (m.8969G>A, p.S148N). Whole exome sequencing did not identify mutations or variants in PUS1 or YARS2 or any known nuclear genes that could affect mitochondrial function and explain this phenotype. Studies of fibroblasts derived from the patient revealed a decrease in oligomycin-sensitive respiration, a finding which is consistent with a complex V defect. Thus, this mutation in MT-ATP6 may represent the first mtDNA point mutation associated with the MLASA phenotype.
Gestión del recurso humano, estudio de caso “QUEVEXPORT S.A.” Cantón Quevedo 2015.

This case study was implemented in the company QUEVEXPORT located at Km. 1 ½ Road to Valencia, in order to determine what the effect of administrative management unit Talent Company Quevexport SA on the job performance of employees and workers, research the following objectives: Diagnose the administrative management of Human Resource Unit in the company QUEVEXPORT Identify the factors that have influenced efficient and inefficient job performance of staff.
Types of field research and literature in order to extract practice, actual information and theoretical information regarding the object of study were applied. The research methods were inductive and analytical methods that allowed analyzing the results will attain the objectives of the research. The survey technique applied to the entire study population, comprising a total of 32 employees was used. After the analysis and interpretation of the results it was concluded: the company has a functional organization and has defined the mission and vision; but not been socialized with their employees. There is no planning for human resource management, therefore no terms of personal reference is made either upon frugal recruitment. No regularly evaluates work performance, therefore the climate or the workplace are adequate, the same economic incentives accompanied by sporadic decreases motivation and commitment employer-employee, salvageable company with employees is given in training , job security and respect to the benefits of law; this is more negative than positive indices in identifying occupational factors which generates a degree of inefficiency in work performance were detected.
Identification of phytophthora resistant beech trees by composition of endophyte communities, lesion formation and phenomics approaches.

Invasive alien pathogens and emerging infectious diseases are an unprecedented threat to the capacity of European forests to supply the growing bioeconomy with renewable biomass, carbon sequestration and other essential ecosystem benefits. To strengthen the biosecurity against these pathogens, new, science-based and socially acceptable forest protection solutions need to be developed. The research in RESISTREE will target central knowledge gaps related to a crucial phase of a biological invasion, the establishment phase. Specifically, RESISTREE will deliver in-depth information about the host phenotypic traits and associated mycobiome that can suppress establishment of the invasive Phytophthora-species (Oomycetes) on one of the key stone species of European forests, the European beech (Fagus sylvatica L.). We will test hypotheses about (1) H1 - Endophyte assemblages differ between healthy and Phytophthora-infected beech trees; (2) H2 - Certain endophytic fungi (individual species or groups) limit the growth of Phytophthora-species through different mechanisms; (3) H3 - Lesion formation in beech tissues depends on the quality or quantity of endophytic infections in the tissue; and (4) H4 - Phytophthora root infection influences the growth and morphology of seedlings before visible symptoms (chlorosis,lesions) appear. RESISTREE combines theory and methods from ecology, cell biology, mycology and forest pathology, resulting in an original, multidisciplinary research with high potential for ground-breaking findings. RESISTREE will promote transfer of knowledge between academia and the private sector, resulting in an interdisciplinary project. RESISTREE adheres to priorities of the H2020 program, and follow the European recommendations included in the Directive 2009/128/EC, which calls for non-chemical methods of plant protection.
Topologically protected and scalable quantum bits

Our vision is to enable the world of quantum computing through an unprecedented stable and scalable many-qubit system. This platform will allow us to establish important scientific breakthroughs such as the observation of Majorana bound states, which can lead to the new field of non-Abelian many-body physics.

A universal quantum computer can be exponentially faster than classical computers for certain scientific and technological applications. This long-awaited innovation can help solve many global challenges of our time related to health, energy and the climate, such as quantum chemistry problems in order to design new medicines, material property prediction for efficient energy storage, big data handling problems, needed for complexity of climate physics.

Such a quantum computer has not yet been realized because of qubit fragility and qubit scalability. The output of TOPSQUAD lays the foundation for universal quantum computing with stable and scalable qubits:
We will address qubit fragility by creating topological states, which are insensitive to decoherence. We will address qubit scalability by developing waferscale fabrication technology, using CMOS-compatible processes. After TOPSQUAD, existing integrated-circuit technology can then serve to scale up from individual qubits to 100,000s.

These two approaches have not been combined within a single system, but our recent results show that we can be the first to address the key challenges:
1. For the first time we will synthesise Ge wires on silicon wafers using scalable CMOS-compatible processes.
2. We will devise an unprecedented silicon system with the required topological properties: Ge wires with a silicon shell.
3. The thin Si shell will suppress metallization, thus avoiding the destruction of topological states by proximity-induced superconductivity, a typically overlooked problem.

With this, TOPSQUAD can realize a scalable, CMOS-compatible, topologically protected system.
Renal protective effects of induction of haem oxygenase-1 combined with increased adiponectin on the glomerular vascular endothelial growth factor-nitric oxide axis in obese rats

What is the central question of this study? This study aimed to investigate whether induction of haem oxygenase-1 (HO-1) can protect the kidneys of obese rats by regulating the glomerular vascular endothelial growth factor-nitric oxide (VEGF-NO) axis by increasing the adiponectin concentrations. What is the main finding and its importance? Induction of HO-1 reduces the degree of microalbuminuria and has renal protective effects by improving endothelial function and regulating the uncoupled glomerular VEGF-NO axis in diet-induced obese rats. The mechanism may be related to increased activation of the HO-1-adiponectin axis. The glomerular vascular endothelial growth factor-nitric oxide (VEGF-NO) axis plays a critical role in maintenance of normal kidney function in obesity. Induction of haem oxygenase-1 (HO-1) may result in a parallel increase in adiponectin secretion. The aim of this study was to investigate whether induction of HO-1 could protect the kidneys of obese rats by regulating the glomerular VEGF-NO axis by increasing adiponectin levels. Rats received high-fat diets and were injected with either cobalt protoporphyrin to induce HO-1 or stannous protoporphyrin to inhibit HO-1. Blood and urine samples were collected. Endothelial function was determined by measuring the endothelium-dependent vasodilatation of the aorta. Renal tissues were collected for CD34 immunohistochemistry. The glomerular VEGF-NO axis and the AMP kinase-phosphoinositide 3-kinase (PI3K)/Akt-endothelial nitric oxide synthase pathway were measured. Induction of HO-1 by cobalt protoporphyrin decreased microalbuminuria, plasma free fatty acids, serum high-sensitivity C-reactive protein and malondialdehyde levels and increased serum adiponectin levels compared with the untreated obese rats. Severe impairment of endothelium-dependent vasodilatation was observed in the obese rats, which was improved to some extent by HO-1 induction. Induction of HO-1 reduced glomerular CD34 expression and production of reactive oxygen species in obese rats. Obese rats showed increased glomerular VEGF expression and reduced NO levels. This uncoupling of the glomerular VEGF-NO axis was improved to some extent by induction of HO-1, with enhancement of p-AMP kinase, p-Akt and phospho-endothelial nitric oxide synthase in obese rats. These results indicate that induction of HO-1 with cobalt protoporphyrin reduces the degree of microalbuminuria and has renal protective effects by improving endothelial dysfunction and regulating the glomerular VEGF-NO axis in diet-induced obese rats by increasing adiponectin levels.
A platform to boost robotic innovation by enabling fast development cycles, reduced cost and low  barrier to entry.

Our vision is to make robotic product development as accessible as online publishing is today. Our aim is to power the social and personal robotic revolution.

Today robotic companies have vertical models, they source, conceive, build, mass produce and distribute their own robots. This is a high cost and high risk endeavour that put the brakes on innovation and on the exploration of new markets. To reach its full potential, robotic must transition to a horizontal industry where companies become specialized in one layer of the robotic value chain.

We have conceived a disruptive modular robotic architecture, called Luos, that makes robotic product development much simpler. It takes the form of a set of embedded code libraries, hardware interfaces and control software that enables to bring robots to market in months rather than years. It is the result of years of expertise with patented technologies.

Our envisioned business model is one of a platform. Our basic tools are available in open source to create win-win situations and enable fast market uptake. Robotic companies would pay for premium features recurrently and in proportion with their revenues.

The expected impact is to enable more companies, and primarily technological startups, to develop products involving robotic technologies. This revolution will reach and disrupt a wide range of new markets previously unattainable with conventional development methods. As a result, more innovative products will be created which will lead to an improvement of living standards in our societies. To achieve this potential, it is crucial to build on a first mover advantage to gain time and market shares over competitors.

Our objective for this proposal is to bring our technology to TRL6 level. We target to develop three robotic platforms with three companies in three distinct markets. We will pursue market research and business analysis to identify a first niche market to demonstrate our technology and build reputation.
Improved metallic glasses for small implants through x-ray and biological characterisation of corrosion products

Small metal implants such as dental implants or bone-anchored hearing aids need very good mechanical properties and corrosion resistance to avoid local inflammation and remain integrated in bone.  In GLASSIX, Ti-based metallic glasses will be developed specifically for small implants using a new approach to evaluate biocompatibility.  This is usually tested on passive metal surfaces, but recent work has shown that mechanically-assisted crevice corrosion (MACC) can generate metal particles and corrosion products that damage the surrounding tissue. In situ characterisation of corrosion products with synchrotron X-rays will be used to design standard simulated corrosion products that will then be tested on human cells to evaluate which corrosion products are most damaging.  The findings from this new approach will be fed back into the alloy development process together with information on feasibility of manufacture from Anthogyr, a leading manufacturer.  The project combines the ER’s expertise in metallic glasses, and the expertise of host researchers in corrosion, X-ray methods, clinical and biomedical research, and will equip the ER to carry out cutting edge research in an academic environment that can readily be translated into clinical and commercial success in the biomedical devices sector.
Molecular dynamics study of ion hydration under pressure

Abstract We present results of a molecular dynamics simulation of pressure influence on ion hydration. Four different electrolyte aqueous solutions are considered: NaF, NaCl NaBr, NaI. These systems were modeled at two /pressure,temperature/ regimes: “normal” — 105 Pa, 298 K and “high” — 4 · 109 Pa, 500 K. Structural properties of the considered systems are shown in the form of instantaneous configurations of ionic hydration shells and distributions between the various atoms and/or ions. Dynamic properties are discussed in terms of the self-diffusion coefficients of the ions. We were interested in the pressure effect revealed in evolution of ionic hydration along the transition from “normal” to “high” regime. The results indicate strong changes in the hydration of considered ions as well as their ion-specific behavior.