SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Exposure to the 'Dark Side of Tanning' skin cancer prevention mass media campaign and its association with tanning attitudes in New South Wales, Australia

Melanoma is the most common cancer among 15- to 29-year-olds in Australia, with rates increasing with age. The 'Dark Side of Tanning' (DSOT) mass media campaign was developed in 2007 to influence attitudes related to tanning. This study aimed to assess recall and impact of the DSOT campaign. Data were collected using online surveys of 13- to 44-year-olds living in New South Wales in the summer months of 2007-2010 (n = 7490). Regression models were used to determine predictors of recall of DSOT and to investigate associations between exposure to the campaign and tanning attitudes. The campaign achieved consistently high recall (unprompted recall 42-53% during campaign periods; prompted recall 76-84%). Those who recalled DSOT advertisements had a higher likelihood of reporting negative tanning attitudes compared with those who reported no recall, after adjusting for other factors (odds ratio [OR] 1.13, 95% confidence interval [CI] 1.01-1.27 for unprompted recall; OR 1.19, 95% CI 1.03-1.36 for prompted recall). Being interviewed in later campaign years was also a significant predictor of negative tanning attitudes (e.g. fourth year of campaign versus first year: OR 1.24, 95% CI 1.01-1.53). These results suggest that mass media campaigns have potential to influence tanning-related attitudes and could play an important role in skin cancer prevention.
Impact of unexpected events on inbound tourism demand modeling: evidence of Middle East Respiratory Syndrome outbreak in South Korea

This paper attempts to evaluate how South Korea’s inbound tourist arrivals from China have been affected by the Middle East Respiratory Syndrome (MERS) outbreak. Using quarterly data, the autoregressive distributed lag model (ADLM) is performed to capture the influence of the MERS outbreak. Estimation results of the general ADLM reveal that the MERS outbreak has a significant adverse impact on the total inbound tourist arrivals from China, as well as on tour arrivals; however, for business, official, and other types of tourist arrivals, its influence is insignificant. Furthermore, the error correction model is estimated to demonstrate the long-run equilibrium and short-run dynamics among the underlying variables. Our analysis not only provides empirical evidence on evaluating the impact of the MERS outbreak on different types of tourism demand, but also identifies main determinants and suggests appropriate model specifications for each type of tourist arrivals.
Why is the world green: testing top-down control of plant-herbivore food webs by experiments with birds, bats and ants

Why is the world green? Because predators control herbivores, allowing plants to flourish. This >50 years old answer to the deceptively simple question remains controversial. After all, plants are also protected from herbivores physically and by secondary chemistry. My goal is to test novel aspects of the “green world hypothesis”: ● How the importance of top-down effects varies with forest diversity and productivity along a latitudinal gradient? ● How the key predators, birds, bats and ants, contribute to top-down effects individually and in synergy? I strive to understand this because: ● While there is evidence that predators reduce herbivore abundance and enhance plant growth, the importance of top-down control is poorly understood across a range of forests. ● The importance of key predatory groups, and their antagonistic and synergic interactions, have been rarely studied, despite their potential impact on ecosystem dynamics in changing world. I wish to achieve my goals by: ● Factorial manipulations of key insectivorous predators (birds, bats, ants) to measure their effects on lower trophic levels in forest understories and canopies, accessed by canopy cranes, along latitudinal gradient spanning 75o from Australia to Japan. ● Studying compensatory effects among predatory taxa on herbivore and plant performance. Why this has not been done before: ● Factorial experimental exclusion of predatory groups replicated on a large spatial scale is logistically difficult. ● Canopy crane network along a latitudinal gradient has only recently become available. I am in excellent position to succeed as I have experience with ● foodweb experiments along an elevation gradient in New Guinea rainforests, ● study of bird, bat and arthropod communities. If the project is successful, it will: ● Allow understanding the importance of predators from temperate to tropical forests. ● Establish a network of experimental sites along a network of canopy cranes open for follow-up research.
Desarrollo de la Unidad de Investigación Clínica (Unidad de Investigación Clínica)

El Centro Nacional de Medicina Transitoria e Investigación Clínica (RSKTK) es una infraestructura nacional de investigación integrada por la Universidad de Tartu, la Universidad de Estonia de Ciencias de la Vida y el Hospital de la Universidad de Tartu, con el objetivo de mejorar la investigación sanitaria en Estonia a fin de contribuir al alto nivel de desarrollo de la investigación médica. En la RNB, se dispone de tecnologías y competencias para la investigación biomédica, clínica y veterinaria. El CDR quiere ser socio de los empresarios y del Estado en la realización de la investigación.
The interval between sexual encounters affects male courtship tactics in a desert-dwelling fish

Courtship displays are often important in determining male mating success but can also be costly. Thus, instead of courting females indiscriminately, males might be expected to adjust their signalling effort strategically. Theory, however, predicts that such adjustments should depend on the rate with which males encounter females, a prediction that has been subject to very little empirical testing. Here, we investigate the effects of female encounter rate on male courtship intensity by manipulating the time interval between sequential presentations of large (high quality) and small (low quality) females in a fish, the Australian desert goby Chlamydogobius eremius. Males that were presented with a small female immediately after a large female reduced their courtship intensity significantly. However, males courted large and small females with equal intensity if the interval between the sequential presentations was longer. Our results suggest that mate encounter rate is an important factor shaping male reproductive decisions and, consequently, the evolutionary potential of sexual selection.
Fermenting Red Ginseng Enhances Its Safety and Efficacy as a Novel Skin Care Anti-Aging Ingredient: <i>In Vitro</i> and Animal Study

The objective of this study was to evaluate the anti-aging potential and skin safety of red ginseng (RG) and fermented red ginseng (FRG) using Lactobacillus brevis for use as cosmetic ingredients. Concentrations of uronic acid, polyphenols, and flavonoids, and antioxidant activities were greater in FRG compared to RG. The contents of total ginsenosides were not significantly different. However, the ginsenoside metabolite content was higher in FRG (14,914.3 μg/mL) compared to RG (5697.9 μg/mL). The tyrosinase inhibitory activity (IC(50)) of FRG was 27.63 μg/mL, and more potent compared with RG (34.14 μg/mL), (P<.05). The elastase inhibitory activity (IC(50)) of FRG was 117.07 μg/mL also higher compared with RG (157.90 μg/mL). In a primary skin irritation test, 10% RG and 10% FRG were classified as practically nonirritating materials. In a skin sensitization test, the RG group showed a sensitization rate of 100% and its mean evaluation score of irritation was 1.4, whereas the FRG group showed 20% and 0.2%, respectively. By fermentation of RG, FRG has increased contents of ginsenoside metabolites, such as Rg3, Rg5, Rk1, compound K, Rh1, F2, Rg2, and flavonoids content. Therefore, FRG offers increased anti-wrinkle efficacy, whitening efficacy, and reduced toxicological potency compared to RG.
PROTECTIVE SOLUTION FOR ISOLATING MITOCHONDRIA, USE THEREOF, KIT COMPRISING THE SAME, AND METHOD FOR ISOLATING MITOCHONDRIA

The embodiments according to the present disclosure provide a protective solution, a kit, and a method for isolating mitochondria. The kit includes an extraction tube, a protective solution, and a suction needle. The extraction tube is used to contain cells. The protection solution is used to mix with the cells in the extraction tube to form a mixture solution, and the osmolarity of the protective solution is greater than 0 and less than or equal to 220 moms'/L. The suction needle is used to suck the mixed solution back and forth to facilitate the release of mitochondria from cells. This method and the protective solution may isolate mitochondria from cells with high efficiency in a simple and convenient way, and the isolated mitochondria have excellent good function.
Spectral Response of Water Under Different Concentrations of Suspended Sediment: Measurement and Simplified Modeling

Understanding the spectral behaviour of water is of the greatest importance to the quality management of water resources. Continuous monitoring by remote sensing is therefore essential for administrators seeking the efficient management of its many uses. The aim of this research was to characterise the spectral response of water submitted to different concentrations of sediments of varying textural properties, organic matter and salts, and to identify the implications of these characteristics using simplified modelling. The experiment was conducted at the Radiometry Laboratory of the Department of Agricultural Engineering of the Federal University of Cear&amp;aacute;, Brazil. The soils used in the research came from two areas of irrigated agriculture in Cear&amp;aacute;, one in Morada Nova and the other in Pentecoste. Both soils were classified as Fluvic Neosols; the first saline and the second saline-sodic, and presented significant differences in granulometric composition and organic matter content. From the results, it can be concluded that: (i) sediments added at different concentrations cause an increase and deformation of the reflectance curves, and that maximum spectral partitioning occurs at two reflectance peaks; (ii) derivative analysis favours the identification of wavelengths that best differentiate sediment concentration, allowing more-efficient modelling of the process; (iii) the characteristics of texture, organic matter and salt content have little effect on estimating suspended-sediment concentration in the water, making multiple linear regression modelling a viable option for this purpose.
The relevance study of adaptive kanban in a multicriteria constraints context using data-driven simulation method

The traditional kanban system with a fixed number of cards does not work optimally in an unstable environment. In fact, kanban parameters should be adjusted to follow the variation of demand. Using a new approach with adaptive kanban, in dynamic production environments, kanban parameters are able to change with respect to demand variation, besides the ability to determine the appropriate time to use some temporary kanban cards called extra cards. In this paper, we propose an approach allowing responding to an exceptional variation of demand. We use a simulation platform with ARENA software to study the relevance of the adaptive kanban applied to the sheet metal cutting cell from TRANE Company.
Speleological Tourism Development in the Southern Adriatic Area

In the Adriatic area, the existing speleological heritage has been discovered and studied only to a limited extent. In fact, a part of the karst heritage is appreciated and properly enhanced while another is less known and boosted. In particular, in Albania, despite the enormous potential of karst landscapes, consisting in 7250 km2 plus 260 km2 of evaporitic rocks, there are not enough trained speleologists, associations or groups that practice speleological activities for tourists. Facing and improving this situation affecting the programme area is the main challenge of CAVES. The overall objective of the project is to foster the speleological tourism sector in order to promote show caves through planning two new itineraries and creating a cross-border network to exchange experiences. The expected change is an increase in the offer related to the speleological tourism in the programme area. To achieve this goal, LP will organize a workshop with Albanian speleological personnel, training them to carry out explorations throughout the national territory and accompany hikers in horizontal caves, sharing the best practices of GSM and the guides of Castellana caves. Following this first output, a B2B activity will be organized in Albania between tourist operators in order to promote the two itineraries valorizing Albanian karst areas and their natural assets. Finally, the third project output will be a Seminar on speleological karst phenomena, organized by LP in cooperation with the Polytechnic of Bari with the aim to create a joint cross-border strategy promoting speleological sustainable tourism also thanks to the contribution of experts from Montenegro. The project will adopt a new approach that will enable operators of this niche tourism sector to work together, exchanging good practices and implementing a successful trans-boundary strategy to enhance and diversify offer of speleological tourism.
Synaptic promiscuity in brain development

Precise synaptic connectivity is a prerequisite for the function of neural circuits, yet individual neurons, taken out of their developmental context, readily form unspecific synapses. The goal of this proposal is to understand the roles and requirements of such promiscuous synapse formation during brain development. The observation of promiscuous synapse formation is not at odds with precise outcomes. The developmental program can ensure correct partnerships between neurons that form synapses promiscuously, but to what degree remains largely unresolved. My group has developed live imaging and optogenetic manipulations of dynamic synaptic choice processes in the intact developing fly brain. We found that time, location and the kinetics of filopodial interactions restrict to a remarkable degree the specificity of synaptic contacts between neurons that can form synapses with many partners if not actively prevented from doing so. A second surprise finding that motivates this proposal suggests markedly different connectomes of flies that developed at 18°C and 25°C, including synapse numbers and partnerships. These differences can be traced back to interaction kinetics during development, thus revealing a level of synaptic promiscuity that can be exposed through temperature alone. The time is ripe for a quantitative assessment of the extent to which synaptic connections are the result of developmentally regulated promiscuous synapse formation. The quest to understand the molecular mechanisms of brain wiring has largely focused on guidance cues and synaptic recognition, fields in which great progress continues to be made. This proposal offers to approach the question of synaptic specificity from the much rarer, but complementary perspective of the alternative limiting case, the hypothesis of synaptic promiscuity. SynPromiscuity is devised to balance the risks of a contrarian approach with its relevance for neurodevelopmental precision and plasticity in health and disease.
Modelling and control of proton exchange membrane fuel cell

Proton exchange membrane fuel cell (PEMFC) has been considered as one of the most promising energy sources due to its many desirable properties, including high power density, low operating temperature and fast start-up. However, significant technical challenges exist before PEMFC can be commercialized. Among them, the modelling and control of PEMFC have been recognized as the most critical technical issues. This is because PEMFC's inherent nonlinearities, time-varying characteristics and tight operating constraints inevitably give rise to great challenges for system modelling and control. The objective of this thesis is then accurate modelling and efficient control of PEMFC. To accomplish these goals, new modelling and control methods are developed and validated.

First, a new empirical model of PEMFC is developed by mapping performance outputs as a function of various operating conditions through regression analysis of support vector machine (SVM). Further, the empirical modelling approach is integrated with the mechanistic modelling method to develop a combined model of PEMFC, which consists of an empirical submodel for the reference voltage and a mechanistic submodel for the correction voltage. Simulation results demonstrate that these models have desirable properties, including good accuracy, fast response and low computational burden. These characteristics lay the solid foundation for the development of control strategies.

Then, various control strategies are developed, including model predictive control (MPC) for regulating PEMFC outputs to the desired value, extreme seeking control (ESC) for tracking the maximum efficiency point and linearized-model-based control for PEMFC thermal management. Simulation results demonstrate that each of the control strategies achieves the control objective that it is supposed to accomplish.

Finally, a full picture of future hydrogen economy in China is given, including drivers for transition to the hydrogen economy, energy resources and their potential role in future hydrogen production, government's policy and support for the research of hydrogen and fuel cell technology.
Développement des réseaux internationaux de l’Institut Pyhäjärvi

Le projet vise à renforcer la coopération et l’expertise internationales de Satakunta et permet à l’Institut Pyhäjärvi de préparer des projets internationaux dans le cadre des programmes Interreg, LIFE et Horizon 2020 de l’UE. Au cours du projet, un réseau de coopération internationale sera mis en place et un certain nombre de projets seront préparés pour renforcer l’Institut en tant qu’acteur national et international.
Finite element modeling of static tire enveloping characteristics

To investigate static tire enveloping characteristics, a three dimensional (3-D) finite element model is proposed. The vertical stiffness of the tire is studied on a flat surface with and without cleat. Tire rubber materials and cord layers are represented independently using “rebar” elements available in MSC Marc Mentat. Comparisons of numerical and experimental results are given to show the validity of the proposed model. It is shown that after a certain displacement, the results of the proposed model agree well with experimental results. In addition, the model results show that regardless of the type of the cleat placed under the rim center (hub center), all vertical force curves intersect after a certain displacement, which indicates typical static enveloping characteristics. Moreover, another typical characteristic of the radial tires that is unlike those of bias-ply constructions confirms that the contact patch does not expand laterally after a level vertical load is applied to the tire, which is directly related to fuel consumption and tire tread life.
Tumor-Lock: forbid the generation of circulating tumor cells

One woman in eight is destined to develop breast cancer. All women that lose their battle against breast cancer vividly realize that its most deadly feature is not the primary lesion, but its ability to spread to distant sites and become an incurable, metastatic disease. In this proposal, we aim to address what is arguably the most ambitious challenge in the cancer field: metastasis prevention.

	Metastatic spread of cancer occurs through the generation and hematogenous dissemination of circulating tumor cells (CTCs). We recently discovered that CTCs are heterogeneous, and that CTC clusters – multicellular aggregates of cancer cells and immune cells in circulation – represent the most powerful mediators of disease spread (Szczerba et al., Nature, 2019; Gkountela et al., Cell, 2019). Post-intravasation biological and clinical features of CTCs are extensively interrogated, yet, surprisingly, the mechanisms that dictate their generation from a solid tumor lesion are unknown. Only a minimal fraction of cancer cells is capable to intravasate in functional blood vessels, while the vast majority of tumor cells will always remain in situ. Understanding the fundamental biological principles that govern CTC generation is of paramount importance, as it could lead to the development of new therapeutic agents that lock tumor cells in their primary site, thereby preventing metastasis.

	Our preliminary data strongly suggest that CTC generation is not occurring in a stochastic fashion, but it is dictated by very precise and previously-unappreciated signals. Based on these very exciting findings, the two predominant goals of this proposal are: first, to gain insights into those fundamental cell-autonomous and non-cell-autonomous mechanisms that govern CTC intravasation in vivo. Second, to identify actionable targets and direct treatment opportunities to lock tumor cells in situ and blunt CTC generation, with the long-term ambition to prevent the metastatic spread of breast cancer.
Evolution of cognitive tools for quantification

Exact quantification, including the ability to count, depends on both conceptual breakthroughs and cognitive tools such as numeral systems. These tools appear in striking diversity across cultures and manifest in different modalities (verbal, body-based, written, or material). To address the tantalizing questions of when, why, and how they emerged and evolved, we test two previously untestable key hypotheses: that conceptual breakthroughs and tools co-evolved, with different modalities coactively scaffolding the breakthroughs; and that the tools diversified in response to changing cultural requirements. Reconstructing this evolution is the prime goal of QUANTA. Addressing its ambitious objectives requires an unprecedented synergetic combination of (i) archaeological, ethnographic, and linguistic insights into numeral systems worldwide, including prehistoric artefacts and symbols, and on contemporary contexts in which quantification occurs and changes; (ii) a cognitive framework for deriving evolutionary hypotheses from system properties; (iii) powerful computational (phylogenetic) methods for testing these hypotheses and thereby reconstructing cultural evolution; and (iv) innovative means to substantially extend the temporal scope of these methods into the past, to include the first attested instances of quantification. To achieve this goal, QUANTA brings together four leading PIs with unique and complementary expertise in exactly these means. By integrating an evolutionary approach with a cognitive perspective on quantification, QUANTA will transform this research field. Its novel strategy will, for the first time ever, yield substantiated insights into the emergence and evolution of numeral systems, thus advancing our understanding of human cognition and its dependence on cultural tools. While the highly interdisciplinary, multi-method approach renders this a high-risk project, QUANTA has the potential to bridge the gap between previously incommensurable fields.