SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Targeting astrocytes with cutting-edge editing technologies to treat the alexander disease

Alexander disease (AxD) is an autosomal dominant neurodegenerative disorder caused by missense mutations in the gene encoding the glial fibrillary acidic protein (GFAP), the major intermediate filament protein in astrocytes. Accumulation of GFAP aggregates in Rosenthal fibres leads to impairment of proteasomal activity and hyperactivation of the stress response, thus compromising astrocyte functions and altering the homeostasis of the central nervous system (CNS). Currently, this orphan disease lacks a cure. 
The proposed project aims at providing in vivo proof-of-concept of safety, efficiency and efficacy of a novel and definitive AAV gene therapy approach based on gene editing / base editing strategies targeting GFAP mutational hotspots to recover pathological phenotypes in astrocytes. The candidate expects to outline novel editing platforms for widespread in vivo targeting of CNS astrocytes that could be applied for the treatment of AxD, as proposed in ASTRO-EDITING, and prospectively for disease modelling studies and therapeutic treatments of other neurological and psychiatric disorders by targeting pathological pathways involved in primary astrocyte degeneration or dysfunctional/maladaptive astrogliosis.
The proposal addresses the European issue of Horizon 2020, in the social challenge “Health, Demographic Change and Wellbeing” endeavours for the call “Better health and care, economic growth and sustainable health disease”, subject SC1-BMC-04-2018 “Rare Disease European Joint Programme Cofund”. 
The expertise of the host laboratory, the international environment of OSR and the personalized career development plan will significantly reinforce candidate's competences and knowledge in the gene therapy field, expand his portfolio of therapeutic areas, create a new research niche, and strengthen his organizational, management and interpersonal skills, thus favouring the progressive acquisition of independence as experienced researcher in the scientific community.
Clinical evidence to demonstrate that simultaneous growth of epithelial and fibroblast cells is essential for deep wound healing

The aim of this study was to evaluate the chronic wound healing properties of tannin rich plant extracts.The cell growth stimulating potential of 128 procyanidin rich plant extracts was evaluated in in vitro cell culture models. For clinical trial, a 3% solution of two plant extracts having synergistic effect on cell growth was prepared in glycerol and honey. Placebo test product contained only glycerol and honey. 93 adult patients with one or more lower extremity deep wounds were divided at randomly in two groups. 41 patients in the placebo (AS-22) and 52 in the active treatment (AS-21) groups having respectively 49 and 69 wounds of a mean surface area of 56.70 and 52.03 cm(2), and volume of 57.22 and 52.15 cm(3), were treated by applying the test products topically for a period of 6-weeks.A statistically significant difference was observed between the placebo and the AS-21 treated groups with respect to reduction in the wound surface area (33.37 vs 97.87%) and wound volume (29.45 vs 94.17%) after 6-weeks of treatment. Mean wound humidity and pain scores were also reduced.Tannin rich plant extracts are highly interesting for the treatment of chronic wounds.
The role of von willebrand domain-containing protein 8 in mitochondrial physiology

Mitobetes project brings a new research on poorly characterized mitochondrial protein involved in important cellular and
physiological processes such diabetes, kidney failure and cancer. It also aims on the role of mitochondria in diabetes, the
disease which affects almost 10% of European population. The mitobetes project has a potential to help to find a new
mitochondrial protein involved in diabetes, find a mechanism of diabetes development, increase the public knowledge about
diabetes and thus helps to decrease EU healthcare costs.
Mitochondria are crucial organelles not only in energy conversion, but also in a plethora of other biological processes. Their
function is closely related to their dynamics, controlled by the pro-fusion proteins Mitofusin (Mfn) 1 and 2 and Optic atrophy 1
(Opa1); and by the fission proteins mitochondrial fission factor (Mff) and dynamin related protein 1 (Drp1). Opa1 not only
controls mitochondrial fusion, but also shape of the mitochondrial cristae, a crucial parameter in determining mitochondrial
function and participation in apoptosis. Opa1 exists in high molecular weight complexes of unknown composition that are
dynamically modulated during cristae remodeling.
Recently, the host laboratory completed a proteomic catalogue of proteins associating with Opa1 in intact cristae and leaving
the complex only when cristae shape was disrupted. Among the hits associating with Opa1, the host lab discovered Von
Willebrand Domain-containing Protein 8 (Vwa8), a mitochondrial protein of unknown function whose higher levels correlate
with worse prognosis of Acute Myeloid Leukemia (AML). Here, I propose to understand the function of Vwa8 in mitochondrial
network and cristae shape, Opa1 function, apoptosis and bioenergetics. This project will not only characterize the role of a
novel protein in involved mitochondrial morphology and function, but also verify if a link between mitochondrial morphology
and AML exists.
Energy Efficient Public Buildings in Central Europe

Addressing poor energy performances of public buildings is at the core of EU’s Energy Efficiency Directive and Energy Performance Building Directive but also one of growing financial issues in Central European countries. To address that eCentral project will support key stakeholders to realize benefits of newly implemented building standard - nearly zero energy building (nZEB). eCentral project will prove that nZEB approach, although innovative, is optimal and cost-effective solution for renovation and construction of public buildings. Project aims to capitalise on results of previous and ongoing EU initiatives. Austria has a proven track record with nZEB renovation projects and will be leading other implementing partners (CRO, SLO, HUN) by example. Transnational cooperation will be used to receive maximum international visibility of selected pilot actions. Main outputs of the project are:energy performance certificate (EPC) Tool for public authoritiesdeployment and promotion of innovative financing schemestraining programme and project development assistance for nZEB projectsbuilding renovation strategies for selected regionsstate of the art pilot nZEB public buildings in selected regionsestablished cooperation with scientific institutions and other nZEB initiativesTransnational Assessment and Support Group, formed from project experts and scientific institutions will act as a support team and provide quality checks of each output. EPC Tool will be developed and used by public sector decision makers and project developers beyond eCentral project lifetime. Trained energy efficiency teams within the regional government will serve as a backbone for conducting future nZEB projects. The European Academy of Bolzano (EURAC), one of the leading centres of expertise on energy efficiency in the Central Europe region, will focus on policy analysis and dissemination of eCentral project results.
Gestural meanings: typology and interface constraints

The proposed project 'Gestural Meanings: Typology and Interface Constraints' (GeMeTIC) will investigate how gestures, i.e., hand/body movements and facial expressions, contribute to the meaning of spoken utterances. This question has recently gained substantial traction in formal semantics and pragmatics, but to fully address it, however, one needs to understand how the general potential of gestures to encode meaning is further constrained at various levels of linguistic representation (pragmatics, compositional semantics, syntax, linearization, prosody, articulation) and interfaces between those levels---an issue that still lacks a comprehensive investigation. GeMeTIC will address this gap by comparing the behavior of gestures that contribute ""not-at-issue"" content, i.e., secondary content added on top of the main message of the utterance, to spoken expressions with similar semantics along a range of dimensions: (i) behavior of not-at-issue gestures and spoken expressions under ellipsis and in attitude reports; (ii) behavior of indexicals (i.e., context-sensitive expressions such as 'I', 'here', and 'now') in the scope of quotative gestures and spoken expressions; (iii) non-compositional interpretations (i.e., interpretations that don't match the syntactic structure of the utterance) of expressive gestures and spoken expressions. The ultimate goal of GeMeTIC will be to build a cross-modal typology of not-at-issue meanings that specifies interface constraints on how different meaning types can be encoded in speech and gesture. To accomplish its empirical goals, GeMeTIC will rely on introspective judgements from individual speakers, corpus data, and quantitative data from experiments conducted online. The theoretical component of the project will bring together two major lines of research in formal linguistics: semantics of gestures and semantics of not-at-issue expressions.
10992-Gb/s WDM-OFDMA Uni-PON with Dynamic Resource Allocation and Variable Rate Access

This paper proposes a novel wavelength division multiplexing-orthogonal frequency multiple access (WDM-OFDMA) union passive optical network (uni-PON) architecture with dynamic resource allocation and variable rate access. It can offer an infrastructure with different access solutions. According to the quality of service (QoS) requirement of different services, the optical local terminal (OLT) can dynamically assign different resources as well as the access rates to different services. An experiment has been demonstrated with 4 wavelengths achieving combined signal at 109.92-Gb/s. A physical-layer adaptive algorithm is employed for the resource allocation and variable rate access. The different services with different resource allocations and variable access rates are also demonstrated in the experiment.
CALCIUM OXIDE COMPOUND WITH HIGH PURITY

This invention is about calcium oxide. The invention relates more particularly to obtaining the calcium oxide with high purity and on the implementation.
Multiscale Modeling of Magnetic Materials

come from teaching and research institutions in France or abroad, or from public or private research centers.L'archive ouverte pluridisciplinaire HAL, est destinée au dépôt et à la diffusion de documents scientifiques de niveau recherche, publiés ou non, émanant des établissements d'enseignement et de recherche français ou étrangers, des laboratoires publics ou privés.
DVI Brumadinho sob a perspectiva Médico Legal: relato de experiência

Este trabalho relata os procedimentos aplicados no atendimento ao DVI BRUMADINHO pela equipe do Instituto Médico Legal André Roquete – Belo Horizonte/MG. Acredita-se que conhecer os desafios enfrentados e soluções encontradas poderá auxiliar a comunidade científica em outras situações de desastre no âmbito forense.
Enhancing digital security, privacy and trust in software

Users often get exposed to security and privacy (S&P) threats when they use digital services for social networking, entertainment, banking, education, health, or home security. The factors behind digital S&P threats are numerous and interconnected, as a combined result of inappropriate software practices, bad user habits, and lack of regulatory enforcement and certification methods, among others. To define effective digital S&P policies and to establish a long-term vision, it is needed to have data, information, and a body of knowledge on privacy, data protection and the associated ethical, legal and socio-economic aspects.
TRUST aWARE aims to address this situation by providing actionable intelligence and tools for the different connected stakeholders, to offer effective mechanisms to protect the freedom, security, and privacy of citizens, enhancing TRUST on SoftWARE, cybersafety, and EU’s market position. TRUST aWARE will facilitate this by delivering:
- User-friendly tools to protect consumers against S&P cyberthreats (attacks, abusive practices, inappropriate behaviours of digital services) to enable them to better understand, control, detect and respond to S&P threats in a timely manner, and configuring their own S&P protection settings.
- Collective intelligence for CERTs and Authorities in collaboration with citizens, CISOs and DPOs to ensure and audit that digital products and their S&P practices are transparent, secure and compliant with regulation.
- Knowledge to foster S&P-by-design in software engineering by supporting developers and operators with standards and certification methods for compliance with S&P regulations.
By providing tools for key stakeholders along the whole cycle (TRUST aWARE virtuous cycle), and supporting cooperation and intelligence sharing, TRUST aWARE will minimize the impact of cyberthreats, empowering users, promoting collective awareness, and encouraging trustworthy S&P-preserving digital products in compliance with regulation.
Real-Time Massively Distributed Multi-object Adaptive Optics Simulations for the European Extremely Large Telescope

The European Extremely Large Telescope (E-ELT) is one of today's most challenging projects in ground-based astronomy. Addressing one of the key science cases for the E-ELT, the study of the early Universe, requires the implementation of multi-object adaptive optics (MOAO), a dedicated concept relying on turbulence tomography. We use a novel pseudo-analytical approach to simulate the performance of tomographic reconstruction of the atmospheric turbulence in an MOAO system on real datasets. We simulate simultaneously 4K galaxies in a common field of view on massively parallel supercomputers during a single night of observations. We are able to generate a first-ever high-resolution galaxy map at almost a real-time throughput. This simulation scale opens new research horizons in numerical methods for experimental astronomy, some core components of the pipeline standing as pathfinders toward actual operations and future astronomic discoveries on the E-ELT.
Disks in the sky: A reassessment of the WMAP “cold spot”

We reassess the evidence that WMAP temperature maps contain a statistically significant "cold spot" by repeating the analysis using simple circular top-hat (disk) weights, as well as Gaussian weights of varying width. Contrary to previous results that used Spherical Mexican Hat Wavelets, we find no significant signal at any scale when we compare the coldest spot from our sky to ones from simulated Gaussian random, isotropic maps. We trace this apparent discrepancy to the fact that WMAP cold spot's temperature profile just happens to favor the particular profile given by the wavelet. Since randomly generated maps typically do not exhibit this coincidence, we conclude that the original cold spot significance originated at least partly due to a fortuitous choice of using a particular basis of weight functions. We also examine significance of a more general measure that returns the most significant result among several choices of the weighting function, angular scale of the spot, and the statistics applied, and again find a null result.
[Clinicopathological features and outcomes: analysis of 21 cases of lymphoma in pregnancy].

To evaluate the clinicopathological features and outcomes of lymphoma in pregnancy.A total of 21 patients with lymphoma in pregnancy were diagnosed and treated at our hospital between January 1999 and January 2012. The clinicopathological data were analyzed retrospectively.There were 11 cases of Hodgkin's lymphoma (HL) and 10 cases of nodular sclerosis classical Hodgkin's lymphoma (NSCHL). And, among 10 cases of non-Hodgkin's lymphomas (NHL), there were diffuse large B cell lymphoma (n = 6),B-cell lymphoma, non-classifiable with features intermediate between diffuse large B-cell lymphoma and Burkitt lymphoma (n = 1), small lymphocytic lymphoma (n = 1), anaplastic large cell lymphoma with anaplastic lymphoma kinase (ALK) positive (n = 1) and T-cell lymphoblastic lymphoma (n = 1). The median age was 26(22-35) years.Superficial lymphadenopathy was more common in HL than in NHL (10/11 vs 3/10, P = 0.008). At diagnosis, bulky disease and extranodal involvement were more prevalent in NHL than in HL (8/10 vs 2/11, P = 0.009; 7/10 vs 2/11, P = 0.030). All patients received chemotherapy and those with early stages also had combined radiotherapy. Ten patients with HL and 6 patients with NHL achieved complete remission. During a median follow-up of 90 months for HL, the 5-year progression-free survival (PFS) and overall survival (OS) rates were 87.5% and 100% respectively. And during a median follow-up of 31 months for NHL, the 2-year PFS and OS rates were 66.7% and 77.8% respectively. The values of PFS and OS of NHL were inferior to those of HL (P = 0.073 and P = 0.066 respectively).One case of HL and 1 case of NHL received chemotherapy in the second trimester. The patients and their children experienced good outcomes.NSCHL is the most prevalent subtype of HL during pregnancy. B cell lymphoma and aggressive subtypes are most common for NHL during pregnancy. The outcomes of NHL are inferior to those of HL during pregnancy.
Sentinels synergy for agriculture

In the emerging Copernicus Earth monitoring era, Europe provides Earth Observation (EO) data from Sentinel-1 (S1) and Sentinel-2 (S2) on a free and open data policy basis. In response of the EO Work programme ‘EO-3-2016: Evaluation of Copernicus Services’, Sentinels Synergy for Agriculture (SENSAGRI) aims to exploit the unprecedented capacity of S1 and S2 to develop an innovative portfolio of prototypes agricultural monitoring services. When used alone either optical or radar sensors allow the mapping of crop types. However more robust, accurate, frequently updated and comprehensive crop maps are expected from the seldom exploited synergy of both types of measurements. The same holds when dealing with crop status, health and stresses. Experimental studies have demonstrated that fusion of optical and radar data opens up prospects for enhanced monitoring capabilities. SENSAGRI will exploit the synergy of optical and radar measurements to develop three prototype services capable of near real time operations: (1) surface soil moisture (SSM), (2) green and brown leaf area index (LAI) and (3) crop type mapping. These prototypes shall provide a baseline for advanced services that can boost the competitiveness of the European agro-industrial sector. SENSAGRI proposes four advanced proof-of-concept services: (i) yield/biomass, (ii) tillage change, (iii) irrigation and (iv) advanced crop maps. The algorithms will be developed and validated in four European agricultural test areas in Spain, France, Italy and Poland, which are representative of the European crop diversity, and their usefulness demonstrated in at least two non-European countries. In order to refine the specifications of the products and to iteratively assess the services, actors of the agricultural sector will be involved using a Living Lab approach. The combination of user-centered approach and of state-of-the-art algorithms will establish a sound foundation for deciding of a new Copernicus land service.
Rituais em Desaparecimento

Resenha crítica do livro Vom Verschwinden der Rituale, de Byung-Chul Han. Han, B.-C. (2021). O desaparecimento dos rituais: uma topologia do presente. Tradução: Gabriel Salvi Philipson. Petrópolis: Vozes, 160 p. [Han, B.-C. (2019). Vom Verchwinden der Rituale: eine Topologie der Gegenwart. Berlin: Ullstein. 4. Auflage. 121 p.]
Capacity Building of BLUE Economy Stakeholders to Effectively use CROWDFUNDING.

Blue economy innovation in Mediterranean could be significantly improved, if more investment funds would be available. One possible solution is use of Crowdfunding (CF) but in MED area knowledge and capacities for CF are still low in comparison to North EU. Project general objective is to improve innovation capacities in blue growth sector by mainstreaming use of crowdfunding.Methodology will be adapted from Interreg Central CROWD-FUND-PORT project and Interreg MED - FINMED by LP and PP6 who were coordinator/partner in those projects.Project will deliver: 

1.) Capacity building of blue economy SMEs on how to use CF;

2.) Transnational blue-crowdfunding cluster with developed CF services;

3.) Mainstreaming the international CF trainings in business support institutions;

4.) Mainstreaming policy change and recognition of using civic crowdfunding in regions.Results will be delivered by mix of 13 partners from 8 MED countries including 4 blue economy clusters/chambers, 3 crowdfunding experts, 2 academia and 4 regions. Following blue economy sectors will be reached: blue energy, maritime safety, maritime transport, maritime tourism, fisheries and aquaculture.Project ambition is to trigger change from using public funds for innovation to use crowdfunding and crowdsourcing to fund, test and validate innovative blue economy products and services. Consequently blue-economy SMEs will get better access to funding and will be able to deliver better and more innovative solutions.
Inuit Traditional Ecological Knowledge (TEK) Subsistence Hunting and Adaptation to Climate Change in the Canadian Arctic

This paper examines the role of Inuit traditional ecological knowledge (TEK) in adaptation to climate change in the Canadian Arctic. It focuses on Inuit relationships with the Arctic environment, including hunting knowledge and land skills, and examines their roles in adaptation to biophysical changes that affect subsistence hunting. In several instances, TEK underpins competency in subsistence and adaptations to changing conditions, which includes flexibility with regard to seasonal cycles of hunting and resource use, hazard avoidance through detailed knowledge of the environment and understanding of ecosystem processes, and emergency preparedness, e.g., knowing what supplies to take when traveling and how to respond in emergency situations. Despite the documented importance of TEK in adaptation and in maintaining a level of competency in subsistence, the relationships between TEK and adaptation to climate change are not well defined in the scholarly literature. This paper aims to conceptualize the relationships between TEK and adaptation to climate change by drawing on case study research with Inuit in the Canadian Arctic. TEK is considered an element of adaptive capacity (or resilience) that is expressed as adaptation if TEK is drawn upon to adapt to changing conditions. This capacity depends on the development, accumulation, and transmission of TEK within and among generations.