SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Novel target for treatment of chronic inflammatory diseases

Lipum AB has discovered a novel target protein for treatment of chronic inflammatory diseases. We are now developing a biological drug that will inhibit the target molecule. We propose an entirely new therapeutic mode of action as an alternative to current therapeutics that do not provide adequate response in as much as 1/3 of patients. Our research and preclinical results indicate that our approach can be applied for treatment of an array of autoimmune and autoinflammatory conditions, and that the suppression of the patient immune system can be avoided, which otherwise is a common negative side effect limiting treatment options. Currently, Lipum is focused on delivering a humanised candidate drug. Our aim is to to reach a drug development phase where toxicology and safety tests can be started and establish collaborations needed to proceed with the clinical studies. Within the lifecycle of this project, Lipum will focus on providing preclinical evidence, securing IP and reaching out to partners interested in exploitation of our approach for the treatment of Rheumatoid Arthritis and Juvenile Idiopathic Arthritis. These are chronic and debilitating conditions that affect around 1% of adult population (RA) or thousands of children (JIA) worldwide. Both RA and JIA are important cause of disability and generate high costs of healthcare and lost productivityLipum AB is a Swedish SME founded in 2010 with the aim to bring to the market a new biological drug for chronic inflammatory diseases. An effective and safe alternative has been long expected by the millions of patients that struggle with chronic and debilitating conditions like Rheumatoid arthritis (RA), Psoriatic Arthritis (PsA), or Inflammatory Bowel Disease (IBD), and by the rheumatology opinion leaders that have been highlighting the unmet clinical need in this domain. Apart from the patients’ well-being and quality of life, chronic inflammatory diseases incur high social costs of healthcare and lost productivity.
Glyco-Nanoparticles for applications in advance nanomedicine

The advance of nanomedicine requires the development of novel materials with tailored properties, controlled circulation, optimal targeting and therapeutic efficacy after administration.  Nanomaterials engineered with glycans offer multiple possibilities for nanomedicine as these biomolecules when arranged on a nanomaterial surface display strong binding to specific receptors while at the same time the glyco coating can restrict unspecific interactions with proteins, helping to avoid the mononuclear phagocyte system and improved biocompatibility in vivo.
The NanoCarb Network will develop novel and well-characterised nanomaterials with synthetic and native N-glycans that will be used for therapeutics and guide development of new drug delivery applications. 
The project will train early stage researchers at the interface of nanotechnology and glycosciences, with the overall goal of achieving a new generation of professionals in nanomedicine for a prospective career in both academia and industry.
To achieve this goal a multidisciplinary consortium has been created including universities, research centres and SMEs with broad expertise ranging from nanotechnology, carbohydrate chemistry, glycoprofiling and in vitro – in vivo screening specialists.  An ambitious training plan will be implemented including courses, outreach activities, participation in seminar, and workshops for the development of scientific and transferable skills.
AN IMPROVED PROCESS FOR THE PREPARATION OF 3-[2-[4-(6-FLUORO-1,2-BENZISOXAZOL-3-YL)-1-PIPERIDINYL]ETHYL]-6,7,8,9-TETRAHYDIO-9-HYDROXY-2-METHYL-4H-PYRIDO[1,2-A]PYRIMIDIN-4-ONE.

A process for the preparation of paliperidone from the hydrolysis of paliperidone palmitate in the presence of an acid in a solvent.
Disruptive polyurethane foams with improved passive fire protection to increase energy efficiency & safety in buildings, houses and transport.

Nearly Zero Energy Buildings are nowadays the focus of construction companies since EU Directives aim to reduce the Carbon emissions to atmosphere. Buildings are responsible of 28% of all CO2 emissions with space heating accounting 65% of all energy consumed. The need for reducing heat leaking through a better insulation of constructions is a key strategy to reduce the CO2 emissions responsible of the Climate Change. On the other hand, the rationalization on the consumption fossil resources through the use of renewable and biobased raw materials is of a strong interest for customers and end-users in construction market. In addition to the thermal performance and sustainability, insulating materials must demonstrate a safe use, especially when a fire takes place.

Polyurethane foams (PUR) are the most efficient insulating materials used in construction. However, the main critical problem for them to become the preferred insulation material is a dangerous behavior when exposed to flames due to their high flammability and fast fire propagation, as well as the high amount of extremely toxic fumes released by PUR materials hen burning.

To address these challenges, INDRESMAT has developed SAFE-PUR, a new top class of biobased PUR insulating foams that solve the main critical problems related with the lack of passive fire safety of conventional PUR foams. SAFE-PUR foams offer the following results: 1) improve the Thermal Insulation in buildings 15-20 %, 2) increase the Passive Fire Protection 70-80% and 3) reduce the C-footprint 60-70% of insulation materials compared to conventional of PUR foams. 

Our target is to reach a 12% of our Serviceable Operative Market partnering with a top chemical manufacturer of PUR formulations interested in SAFE-PUR foams to achieve a large-scale manufacturing representing a potential revenue of 56 M€/y in the next 5 years. After market consolidation our company will develop flexible foams for household, automotive, naval & aerospace.
Defining Urban Sprawl in the Sri Lankan Context: With Special Reference to the Colombo Metropolitan Region

Many scholars agree that there is no clear consensus regarding what “urban sprawl” is or what causes it. The term “sprawl” can be used or defined a number of ways for many situations. When its definition is ambiguous, it is impossible to determine its causes or consequences, including the effects of any policies designed to contain it. In this paper, first, we provide a conceptual definition of urban sprawl based on different dimensions such as density, concentration, proximity to services, automobile dependency, and extent of vegetation cover being paddy, eco-sensitive, or with decreased plantation areas. Such a definition provides a basis for understanding urban sprawl, its nature and its characteristics being location and context specific. Second, an “extended urban area” is demarcated as the geographical base for the study of the urban sprawl. Each dimension is defined and tested in 25 urbanized and suburbanized areas in the Colombo Metropolitan.
Holography and the sound of criticality

Using gauge/gravity duality techniques, we discuss the sound-channel retarded correlators of vector and tensor conserved currents in a class of $(2+1)$-dimensional strongly-coupled field theories at zero temperature and finite charge density, assumed to be holographically dual to the extremal Reissner-Nordstr\"{o}m AdS$_4$ black hole. Using a combination of analytical and numerical methods, we determine the quasinormal mode spectrum at finite momentum for the coupled gravitational and electromagnetic perturbations, and discuss the appropriate choice of gauge-invariant variables (master fields) in order for the black hole quasinormal frequencies to reproduce the field theory spectrum. We discuss the role of the near horizon AdS$_{2}$ geometry in determining the low-frequency behavior of retarded correlators in the boundary theory, and comment on the emergence of criticality in the IR. In addition, we establish the existence of a sound mode at zero temperature and compute the speed of sound and sound attenuation constant numerically, obtaining a result consistent with the expectations from the zero temperature limit of hydrodynamics. The dispersion relation of higher resonances is also investigated.
Ladder Stabilizer

A ladder stabilizer removably mounts to one of the two spaced rails of a conventional ladder, and a mirror image stabilizer preferably mounts to the other rail. The stabilizer is of unitary construction, preferably injection molded from thermoplastic material, and includes a longitudinal member with an open channel along one longitudinal surface, the channel bounded by opposing longitudinal flanges. The member is sized and shaped and of sufficient flexibility to removably mount to the rail at any desired vertical position, and is relatively non-slidable with respect thereto once mounted. An opposite longitudinal surface of the member includes a plurality of step-like serrations. With one stabilizer mounted to each of the two ladder rails, and the ladder leaned against a structure for conventional use, the step-like serrations reduce the risk of movement of the ladder relative to the structure, and therefore promote safe use of the ladder. Also, the composition of the stabilizer protects the structure from any adverse effects.
Online Sentence Novelty Scoring for Topical Document Streams

The enormous amount of information on the Internet has raised the challenge of highlighting new information in the context of already viewed content. This type of intelligent interface can save users time and prevent frustration. Our goal is to scale up novelty detection to large web properties like Google News and Yahoo News. We present a set of lightweight features for online novelty scoring and fast nonlinear feature transformation methods. Our experimental results on the TREC 2004 shared task datasets show that the proposed method is not only efficient but also very powerful, significantly surpassing the best system at TREC 2004.
Recovery of tungsten, niobium and tantalum occurring as by-products in mining and processing waste streams

The extraordinary properties of refractory metals, the unlikeliness of their future substitution and their use in booming industries will sustain a high EU demand for tungsten (W), niobium (Nb) and tantalum (Ta). Despite all three being classified as Critical Raw Materials (CRM) by the European Commission (EC), fractions of these indispensable metals are dissipated as by-products in mining waste streams as well as process scrap. To stimulate their recovery from such complex, low-grade resources, TARANTULA will develop a suite of cost-effective, scalable and eco-friendly – bio-, hydro-, iono-, solvo-, pyro- and electro-metallurgical – processes with high selectivity and recovery rates. These novel technologies, each representing an alternative for one or more process steps of state-of-the-art (SoA) processing lines, will form new routes towards market-ready metals, metal oxides and metal carbides. Flexibility will be the cornerstone of the overall process flowsheet to enable recovery of all three elements (W, Nb, Ta), thereby minimising the CAPEX required for future processing installations. Following systematic research and innovation activities at lab scale, the envisioned technologies will be brought to TRL3-5 and, based on performance, validated at prototype level by experienced industrial partners. In parallel, future by-product recovery will be supported by carrying out a comprehensive identification and assessment of existing un/underexploited secondary sources of W, Nb and Ta. The generated information – in compliance with all pertinent laws and regulations - will feed into the Raw Materials Information System (RMIS) which will boost the impact of the project far beyond the current consortium. Finally, TARANTULA will blueprint tailored Communication, Dissemination and Civil Society Engagement strategies with respect to obtaining and maintaining the “Social License to Operate” for future heavy-duty metallurgical processing.
GROUPE MARCOLD S.R.L. — ACTIONS DE DÉVELOPPEMENT ET DE RECHERCHE DE NOUVEAUX CLIENTS DE LA RÉFRIGÉRATION INDUSTRIELLE POUR L’OIT & GAZ DANS LA FÉDÉRATION DE RUSSA — RUSSIACOLD 20178

GROUPE MARCOLD S.R.L. — ACTIONS DE DÉVELOPPEMENT ET DE RECHERCHE DE NOUVEAUX CLIENTS DE LA RÉFRIGÉRATION INDUSTRIELLE POUR L’OIT & GAZ DANS LA FÉDÉRATION DE RUSSA — RUSSIACOLD 20178
GROWTH AND IRREVERSIBLE POLLUTION: ARE EMISSION PERMITS A MEANS OF AVOIDING ENVIRONMENTAL AND POVERTY TRAPS?

We consider an OLG model with emissions arising from production and potentially irreversible pollution. Pollution control consists of the assignment of permits to firms; private agents also can abate pollution. In this setting, we prove that multiple equilibria exist. Due to the possible irreversibility of pollution, the economy can be dragged into both environmental and poverty traps. First, we show that choosing an emission quota at the lowest level beyond a critical threshold is a means to avoid these two types of traps. We also prove that when the agents do not engage in maintenance, a reduction of the quota leads to a reduction in pollution but also to slower capital accumulation. In contrast, when agents do engage in maintenance, a reduction of the quota provides a double dividend.
The Determinants of Credit Growth in Lebanon

This study aims at defining the credit growth determinants in Lebanon by exploiting a panel data of 34 commercial banks over the period 2000-2015. The empirical results show that deposit growth, GDP growth, inflation, and money supply, all boost bank credit to the resident private sector. Conversely, credit risk, lending interest rate, T-bill rate, public borrowing, and remittance inflows decrease loan growth. We extend our analysis and detect the impact of one year lag of all exploited variables in order to find out if they have a delayed impact on credit growth, where we find several different results. For instance, lag LLP recorded the opposite effect of LLP; ROA does not affect credit growth, whereas its lag lowers credit growth; the impact of a change in money supply amplifies considerably after one year; and finally, the negative impact of remittances fades away after one year.
Reinventing 3d printing into a true multi-material process

Powder bed 3D printing was invented over 30 years ago, has not changed since and is only able to print single material parts. 
Aerosint intends to change that. Aerosint invented a 3D printing technology capable of printing truly multi-material parts with the ultimate goal to be able to combine metals, polymers and ceramics. This capability paves the way to unique parts optimization and functionalization and will bring 3D printing in a new era.
Aerosint is the first multi-material powder bed 3D printing process enabling unique polymer and metal combinations. Our patent-pending technology can print parts that are made of different materials by melting powder layers composed of more than one powder. To achieve that, the Aerosint patterning drums selectively deposit fine powder voxels line by line. The result are powder layers composed of more than one material and ready for sintering. What best illustrates Aerosint unique approach to multi-material. Aerosint’s multi-powder dispenser achieves material change between and within layers. No other existing technology is today capable of doing this. 
We will have two streams of revenue upon market entry: royalty incomes from licensing our technology to 3D machine manufacturers. To help us with revenues faster and to invest in further improvements, we are also considering retrofitting old machines. Considering the sales of 7,000 SLS units worldwide at an average price of €200,000 (current price of SLS printer), our serviceable obtainable market would be €98M (7% of the total sales price). There is no competition in terms of technology but there are substitutes such as printers without Aerosint technology. 
The Phase 1 funding will help us determine the best way to progress and Phase 2 to upgrade the technology. We will benefit the EU helping advanced manufacturing techniques with the new 3D printing technology, creating more jobs in manufacturing and reducing energy consumption and waste in the process.
Pressure dependence of the photoluminescence from γ-In2Se3 thin films prepared using MOCVD with a single-source precursor

Single γ-phase In2Se3 films were prepared by using metal-organic chemical-vapor deposition(MOCVD) with a single-source precursor [(Me)2In(μ-SeMe)]2. The basic physical properties of the grown films were examined by using X-ray diffraction, Raman spectroscopy, and photoluminescence spectroscopy at room temperature. The pressure dependence of the photoluminescence spectrum of the In2Se3 films was measured at room temperature. At 1 atm, 2 PL peaks were observed, one at 1.88 eV due to a bound exciton transition and the other at 1.50 eV due to a bound-to-free transition. While the pressure coefficients, \(\frac{{dE}} {{dp}}|\begin{array}{*{20}c} {} T \end{array}  \) at pressures below 1.4 GPa were nearly zero, the pressure coefficients of both PL peaks at pressures above 1.4 GPa were −25 meV/GPa.
Freshdetect – food safety – fast and reliable

600 million (about 1 in 10 people) in the world fall ill after consuming bacteria contaminated food. Of these, 420,000 people
die, including 125 000 children under the age of 5 years.

Worldwide approximately 1/3 of all food produced is lost or wasted, requiring cropland area the size of China and being
responsible for 8% of all global Greenhouse Gas Emissions. In the EU, every year 88 million tonnes of food are wasted
related with costs estimated to be 143 billion euros. FreshDetect GmbH aims to contribute to a solution of these problems
with the first mobile handheld device developed for rapid determination of the microbiological quality of food (currently meat
products). The FreshDetect device enables non-invasive microbiological testing without additional operational or
maintenance costs. For the first time, the handheld allows hygiene monitoring through the complete meat production process
and creates a new dimension of food safety. Moreover, the FreshDetect technology offers a so far unmatched level of food
process control allowing an optimization of the food production and minimizing food waste.

The current determination of total microbial count in laboratories outlined by §64 of the LFGB (German Food and Feed
Code) takes about 72 hours to properly determine contamination. This renders impossible any process control that is based
on food contamination. The FreshDetect hand-held device needs only 5-10 sec. for the same process, is much less costly
and does not need scientific trained operators or lab technician.

Starting with pork meat and having analysed the top 10 food processing European countries, FreshDetect’s market potential
is 284,000 devices with a market volume of € 3.5 billion. The target users are slaughterhouses, cutting plants, meat
processing companies, retailers, wholesalers and butchers. The goal of the project is to bring our current prototype (TRL7) to
business success with commercialization to these users.
Nutritional Quality of Bivalves, Crassostrea madrasensis and Perna viridis in the Kali Estuary, Karnataka, India

Quality aspects of oysters ( Crassostrea madrasensis) and mussel (Perna viridis) in the Kali estuary, Karwar were examined in different seasons over a 13 month period. Ecophysiological parameters and nutritional quality parameters of oysters and mussel (composition of Protein, Carbohydrate, Lipid and Ash content) were determined at different seasons of the year. Seasonal variations were observed in the nutrient content, with particular regard to protein 52.33% (September 2003) to 63.86% (June 2004); Carbohydrate 14.01% (February 2004) to 25.24% (October 2003), Lipid 8.46% (October 2003) to 18.77% (February 2004) ash 4.21% (February 2004) to 14.82% (September 2004) in oysters whereas in mussels protein 57.39% Â  (March 2004) to 66.51% (November 2003) , Carbohydrate 14.69% (November 2003) to 26.81% (March 2004), Lipid 8.09% (Feb. 2004) to 12.62% (November 2003), ash 6.18% (November 2003) to 9.02% (March 2004) . In spite of this variability, the nutritional quality of the oysters was generally good, especially just before gamete release (premonsoon) when the concentration of nutrients was at its maximum. A low level of fat was detected in the edible meat of oysters and mussels.
Effect of light response on the photocatalytic activity of BiOCl x Br1−x in the removal of Rhodamine B from water

BiOCl
 x
 Br1−x
 catalysts were synthesized through an alcoholysis method and characterized by X-ray diffraction (XRD), transmission electron microscopy (TEM), high-resolution transmission electron microscopy (HRTEM), and diffuse reflectance spectroscopy (DRS). The as-prepared photocatalysts were found to be tetragonal crystal structure and lamellar plate morphology. Their band gaps were between 3.44 and 2.83 eV. The effect of light response on the photocatalytic activity of BiOCl
 x
 Br1−x
 was investigated by degradation of Rhodamine B (RhB). Complete removal of RhB from water was realized under simulated sunlight irradiation for 50 min with BiOCl0.5Br0.5. Mechanism studies showed that photogenerated holes and superoxide anion radicals played important roles in RhB photodegradation. The results of chemical oxygen demand (COD) confirmed RhB mineralization. The effect of light response on the activity of BiOCl
 x
 Br1−x
 was further investigated under monochromatic light irradiation, and BiOCl0.5Br0.5 catalyst exhibited the highest activity. Furthermore, BiOCl0.5Br0.5 exhibited high stability, suggesting its practical application for the removal of RhB pollutant from water.
The evolution of the small business and entrepreneurship field: A bibliometric investigation of articles published in the <i>International Small Business Journal</i>

This article analyses the evolution of the small business management and entrepreneurship fields as reflected in articles published in its premier journal, the International Small Business Journal. It investigates the evolution of the fields through bibliometric examination of all 660 articles published between 1982 and 2012. While small business management has remained the main focus of the journal, there has been a significant growth in the number of articles focusing specifically on entrepreneurship. Also identified in this analysis are the rise of theoretical studies and the relative decline of descriptive work. Parallel to a clear improvement in the rigour of the articles published, the field of small business and entrepreneurship has relied on a multidisciplinary foundation which offers a diverse and multifaceted engagement. Despite this increasing diversity, it appears that small business and entrepreneurship have unique characteristics that distinguish this field from the broader economics and or management discipline.