SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Liposome-Based biomimetic treatment for auto-immune diabetes (t1d)

Autoimmune diseases (AD) affect 5-10% of the global population and require chronic palliative treatments, resulting in lower quality of life and great costs for society. Moreover, a steady rise in the incidence of some AD such as Type 1 diabetes (T1D) has been detected worldwide. Main treatments for T1D are currently based on the continuous administration of exogenous insulin, but none of the 20 existing marketed insulins can achieve a sustained glycaemic level control. Thus, they cannot fully prevent T1D’s long term and acute side effects.

Ahead Therapeutics is a start-up company exploiting a proprietary encapsulation technology to develop treatments for different AD. It has developed an innovative solution for T1D based on the use of liposomes containing auto-autoantigens. Through a biomimetic process, these liposomes can induce antigen specific immune tolerance, stopping the autoimmune reaction and allowing insulin-producing β-cells to recover. Despite its potential for preventive use, Ahead’s treatment is mainly foreseen as a therapeutic reverse vaccine on the onset of T1D, leading to a permanent cure of the disease.

Ahead solution has several competitive advantages derived from its biomimetic/physiologic mechanism of action: long-lasting/permanent effect, non-systemic immunosuppressive, no secondary effects/toxicity, low-cost production, complementary with other therapies.
The liposome-based platform has already been validated in animal models and preclinical non-regulatory assays are being completed. Current feasibility study will be now focus on defining a Regulatory Roadmap & IPR strategy, enlarging key partners network, discover new potential licensees, scaling up liposomes production and analyse deeper market & competitors. 

LIPOBITS is a solid high-potential innovation project expected to support Ahead’s global dimension and to generate 7 high qualified jobs  total incomes of 10,5 M€ by 2022, and < 300 M € considering the whole life cycle of the asset.
Increased plasma levels of phospholipid in Parkinson’s disease with mild cognitive impairment

This study aimed to observe the clinical characteristics and changes in plasma phospholipid (PL) concentrations in Parkinson's disease patients with mild cognitive impairment (PD-MCI), and to investigate the association between these changes and cognitive function to provide a basis for early diagnosis and intervention for PD-MCI patients. Oxidative stress plays an important role in the development and progression of Parkinson's disease (PD). PL, important components in cellular membranes, are critical for the maintenance of cell integrity and function. Lipid peroxidation products are significantly increased in the brains of PD patients. In the present study, plasma PL levels were significantly increased in PD-MCI patients or in PD patients with no cognitive impairment (PD-NCI) compared with controls (p<0.01 and p<0.05, respectively). PL levels were significantly increased in the PD-MCI group compared with PD-NCI patients (p<0.01). There was a negative correlation between plasma PL levels and Montreal cognitive assessment scores (r=-0.542; p<0.001). These findings support the relationship between mild cognitive impairment and membrane injury. The measurement of PL reflects membrane injury in vivo and may be a new useful biomarker for the prognosis of cognitive states in patients with PD.
A Verification Method for Electron Beam Dose Calculations in Radiotherapy

Electron beam models of 9 MeV and 20 MeV were built in a commercial radiotherapy treatment planning system software RayStation. 14 test cases were created with RayStation, including 4 homogeneous water phantom test cases, 6 internal inhomogeneity test cases and 4 surface irregularity test cases, the dose distribution of electron beam plans were calculated in RayStation, and exported to perform gamma analysis with test dose distribution curves in the data set. According to comparison results of 14 test cases, gamma analysis results of the two-dimensional dose distribution were all over 95% by 3%/3mm criteria, and 99% by 5%/5mm criteria. From the results, RayStation Monte Carlo algorithm can accurately simulate and calculate the electron beam dose distribution.
Cross-border, Resilience, Innovation & Governance for the Prevention of Hydrogeological Risk

This project deals with the problem of flood risk due to filled-in watercourses and the ever-increasing number of urbanised areas and waterproofed surfaces, with consequent difficulties in regulating the surface water flow and water bodies receiving outflows, aggravated by the ongoing climate change. The project aims to develop land resilience by promoting green infrastructure for the management of wet weather outflows, to restore the water cycle, facilitate infiltration and reduce runoff effects.  The action plan includes an integrated analysis, creation and transfer of innovative technology and multi-stakeholder training and consultation activities. The above will improve the administrations' capacity to innovate existing plans (Urban Instruments, Flood Risk Management Plans, the Portofino Park Authority Plan, General Plan and Regional Reclamation Programme). The project will carry out pilot actions such as building sustainable urban drainage systems (SUDS), daylighting watercourses and harvesting rainwater for the benefit of the population, artistic and cultural heritage, landscape and environment. The above will reduce the risk coming from water in addition to the pollutants in the receiving water bodies, the energy for pumping water in the drainage network and greenhouse gas emissions, leading to environmental improvement and better usability of the areas. Moreover, the cross-border approach ensures the creation of a replicable governance model adequate to the characteristics and needs of the area. Exchanging ideas and opinions helps with the resolution of complex issues and the gathering of consensus around practices that are still little known (for this purpose, the plan includes the creation of a policy document to summarise strategies).
Implementazione dell'innovativa tecnologia di taglio 3D con sistema informatico aggiuntivo per l'industria dei metalli

Oggetto del progetto è un investimento iniziale della natura di un cambiamento fondamentale nel processo produttivo, consistente nell'implementazione di un'innovativa macchina da taglio al plasma e di un sistema informatico per la gestione del processo produttivo e la fornitura di servizi al processo produttivo. Il progetto consentirà l'implementazione dell'innovazione di processo, prodotto e non tecnologica non applicata in tutto il mondo per più di 3 anni. Il progetto sarà attuato nel periodo 2018-10-2019-12 e comprenderà l'acquisto e l'implementazione di una macchina da taglio al plasma. Valore netto del progetto 1 695 953,00 PLN, sovvenzione 763 178.85 PLN. Contributo proprio: 1 341 293,34 PLN. 2 post saranno creati (2 epcs nel 2019).
Dissecting the functional and therapeutic impact of somatic copy number alterations (scnas)

In 1914 Theodor Boveri described abnormal chromosome counts in cancer cells and speculated that these alterations are the driving force of cancer. Almost 100 years later it became clear that somatic copy number alterations (SCNAs) are one of the most striking characteristics of cancer genomes. SCNAs comprise deletions and amplifications of whole chromosome arms and therefore alter the expression patterns of several hundred genes simultaneously. These alterations show defined patterns suggesting selective pressure, and thus likely contain multiple driver genes, which can shape several tumorigenic properties. Therefore, studying how these events contribute to tumor development will be fundamental to understand cancer biology and develop targeted cancer therapies. However, whereas the function of recurrently mutated driver genes can be readily assessed, studying SCNAs remains challenging so far. This project will overcome these limitations by combining our unique ability to model liver cancer in vivo and in vitro with innovative CRISPR-based genomic engineering technologies. First, we will generate large chromosomal deletions in murine livers and human-derived liver organoids by CRISPR technologies and assess their functional role in cancer development. Furthermore, synthetic lethal interactions generated by these deletions will be evaluated on their therapeutic potential. Additionally, driver genes and driver gene-combinations of amplified chromosomal regions will be investigated using a novel CRISPR/Cas9-based mouse model for endogenous gene activation and chromosome engineering. Finally, we will exploit a novel concept for targeting cancer cells with specific amplifications. Our unique approach will for the first time systematically investigate the functional role of SCNAs in tumor pathobiology, identify new therapeutic strategies specifically tailored for individual SCNAs, and will therefore have high impact for future efforts to understand and combat cancer.
S5 Prevalence Of Ige Sensitisation To 'improver Mix' Enzymes Among Symptomatic Bakers Working In Uk Scratch Bakeries

Introduction and objectives Bakers working in supermarket scratch bakeries in the UK are exposed not only to flour and fungal alpha amylase but also other enzymes, incorporated in a pre-mixed bag of ‘dough improvers’. Bakers and their employers are usually unaware of which enzymes are being used within the ‘improver mix’. We have examined the question of whether supermarket bakers develop sensitisation to ‘improver mix’ enzymes other than fungal alpha amylase. Methods We assayed specific IgE sensitisation in 300 bakers employed by one of two large UK supermarkets who, at routine health surveillance, had declared work related upper or lower respiratory symptoms. Sensitisation was determined using radioallergosorbent assay to enzymes contained within the specific ‘improver’ mix used by the employing supermarket; each mix contained eight individual enzymes which were not necessarily common to both supermarkets. Results Bakers were sensitised to each of the individual ‘improver’ enzymes with a prevalence ranging from 1.8% to 23.9%; the frequency did not appear to be associated with the quantity of enzyme incorporated in the mix. Sensitisation was far more likely if a baker was sensitised also to either flour or fungal alpha amylase; but a small proportion (5%) of bakers who were sensitised to neither flour nor fungal alpha amylase had specific IgE to one or more of the ‘improver mix’ enzymes. Conclusions Bakers working in UK supermarket bakeries can become sensitised to improver enzymes other than fungal alpha amylase. The clinical significance of this remains unclear but the message is important both in the diagnosis of bakers with work-related respiratory symptoms and in any programme of immunological surveillance.
H2O health outcomes observatory

Patients' outcomes and experience of health care can be improved through the systematic capture and use of information from their perspective. We are currently not using all the information we could gain fromPatients' outcomes and experience of health care can be improved through the systematic capture and use of information from their perspective. We are currently not using all the information we could gain from Patient-Reported Outcomes (PROs) to accurately measure value from the patient perspective. This is due to the lack of standardisation, interoperability and implementation of PRO measurement schemes. We urgently need a European scale network of outcomes data collection, analysis and evidence sharing to inform clinical practice and healthcare decisions. To tackle these issues, this public-private consortium brings together scientists, clinicians and professionals to design and set up independent, patient-centred, Health Outcomes Observatories (H2Os).  With input from patients, providers and health care decision makers (health ministries, health insurers, regional health authorities, public health agencies, medicines regulators, health technology assessment agencies), these Observatories will collect data and provide information not only for individual clinical care, but also for evaluation of new technologies and for healthcare decision making. We will establish ethically and legally sound national, or regional, H2Os and run these initially in four countries for three diseases.  Based on a hybrid model of federated and centralised data collection, management and analysis, these Observatories will operate under a governance model that will guarantee that data are protected under jurisdictional data protection law. H2Os will be connected to a pan-European umbrella H2O to facilitate interoperability, guide reproducibility in other countries, and promote the benefit of measuring and using patient-centred outcomes at regional, national, European and global levels.
OPTICAL FILM

Process of forming a titanium dioxide film with controlled optical thickness on a surface comprising a pretreating step, at least one film-forming step and optionally a nucleation step between the pretreating and film-forming step, and articles coated with such a film.
ULTRAFLEX S.P.A.

ULTRAFLEX BEGANN SEINE INDUSTRIEGESCHICHTE IM JAHR 1935 UND ENTWICKELTE SCHRITTWEISE DAS DESIGN UND DIE PRODUKTION VON FÜHRUNGSSYSTEMEN UND ZUBEHÖR FÜR DEN FREIZEIT- UND KOMMERZIELLEN SEEVERKEHRSMARKT, DER HEUTE SEINE TÄTIGKEIT UND SEINEN REFERENZMARKT BILDET UND ZU EINEM WELTMARKTFÜHRER IN DER BRANCHE WURDE. DIE WICHTIGSTEN PRODUKTIONSLINIEN BETREFFEN MECHANISCHE SYSTEME, HISTORISCHE PRODUKTION, HYDRAULIKSYSTEME, ELEKTROMECHANISCHE, ELEKTRONISCHE UND STABILISIERUNGSSYSTEME. IM WERK IN BOX (GE) WERDEN HERGESTELLT UND/ODER MONTIERT: MECHANISCHE SYSTEME: STEUERUNGEN FÜR DIE KONTROLLE DES GASES UND DES WECHSELRICHTERS DES MOTORS EINES SCHIFFES; AUSSENBORDKABEL ZUR ÜBERTRAGUNG DER STEUERUNG AUF DEN MOTOR; MECHANISCHE LENKSYSTEME FÜR DIE VERWALTUNG DER SCHIFFSFÜHRUNG DURCH DAS LENKRAD; EINZELKABEL FÜR DIE ÜBERTRAGUNG DER STEUERUNG VOM STEUERHAUS AUF DEN MOTOR; LENKRÄDER FÜR DIE FÜHRUNG DES BOOTES; ZUBEHÖR FÜR DIE ANWENDUNG
Avaliação de uma intervenção educacional (edworkcases) envolvendo casos clínicos e estudantes de Enfermagem: um estudo observacional transversal

Resumo Objetivo: avaliar o impacto da intervenção educacional (edworkcases) nos resultados da avaliação dos alunos em suas práticas clínicas, suas atitudes em relação aos diagnósticos de Enfermagem e sua satisfação. Método: estudo observacional transversal, realizado com 69 estudantes do terceiro ano de Enfermagem de uma universidade pública de Madri, Espanha. Os dados analisados foram obtidos das notas dos alunos em suas práticas clínicas, bem como, os escores pré- e pós-intervenção na Escala de Posições frente ao Diagnóstico de Enfermagem e uma pesquisa de satisfação. A comparação de médias por participação no projeto (sim/não) foi realizada por meio do teste t de Student. A comparação de médias por professor foi realizada por meio de testes de Kruskal-Wallis. Resultados: taxa de participação: 72,4%; 92% dos participantes eram mulheres; mediana de idade de 21 anos. Foram encontradas diferenças estatisticamente significativas entre participantes e não participantes em termos de pontuação média na Avaliação Geral e na Avaliação do Estudo de Caso, com maiores pontuações encontradas entre o grupo de participantes. A pontuação média das atitudes em relação aos diagnósticos de Enfermagem foi de 99,9 (DP=2,8) antes da intervenção e 111,1 (DP=2,9) após a intervenção [IC 95%: 3,3-19,2]. Conclusão: a utilização de edworkcases como parte do treinamento prático foi considerada satisfatória, permitindo a articulação teoria e prática e melhorando as atitudes dos alunos em relação aos diagnósticos de Enfermagem.
Sacred landscapes in late byzantium

This interdisciplinary project will explore texts composed by the fourteenth-century Constantinopolitan Patriarch Philotheos Kokkinos, with a threefold focus on:
1. The creation of sacred landscape in fourteenth-century Byzantium.
2. The attitude(s) towards and representation(s) of women in late Byzantine patriarchal society.
3. The textual transmission of Kokkinos’ saints’ lives. 
The project includes the preparation of critical editions for two hitherto unedited hagiographical texts written by Kokkinos.

The fellow will receive training in digital humanities and textual criticism which will further his career goal of becoming a lecturer in Medieval Studies. This research project will contribute to a better understanding of Eastern medieval thought-worlds, particularly during the troubled period of the fourteenth century, which saw a shrunken Byzantium struggle for survival between the growing Muslim East and the Latin West.
Security in trusted scada and smart-grids

In traditional industrial control systems and critical infrastructures, security was implicitly assumed by the reliance on proprietary technologies (security by obscurity), physical access protection and disconnection from the Internet. The massive move, in the last decade, towards open standards and IP connectivity, the growing integration of Internet of Things technologies, and the disruptiveness of targeted cyber-attacks, calls for novel, designed-in, cyber security means. Taking an holistic approach, SCISSOR designs a new generation SCADA security monitoring framework, comprising four layers: i) a monitoring layer supporting traffic probes providing programmable traffic analyses up to layer 7, new ultra low cost/energy pervasive sensing technologies, system and software integrity verification, and smart camera surveillance solutions for automatic detection and object classification; ii) a control and coordination layer adaptively orchestrating remote probes/sensors, providing a uniform representation of monitoring data gathered from heterogeneous sources, and enforcing cryptographic data protection, including certificate-less identity/attribute-based encryption schemes; iii) a decision and analysis layer in the form of an innovative SIEM fed by both highly heterogeneous monitoring events as well as the native control processes’ signals, and supporting advanced correlation and detection methodologies; iv) a human-machine layer devised to present in real time the system behavior to the human end user in a simple and usable manner. SCISSOR’s framework will leverage easy-to-deploy cloud-based development and integration, and will be designed with resilience and reliability in mind (no single point of failure). SCISSOR will be assessed via i) an off-field SCADA platform, to highlight its ability to detect and thwart targeted threats, and ii) an on-field, real world deployment within a running operational smart grid, to showcase usability, viability and deployability.
Building science among all, the key role of researchers

The European Researchers’ Night in Madrid will bring together researchers to the general public and will increase awareness of research and innovation activities, with a view to supporting the public recognition of researchers, creating an understanding of the impact of researchers' work on citizen's daily life, and encouraging young people to embark on scientific careers.
ERNMadrid will implement it by means of a set of 107 festive activities to be carried out in the Region of Madrid on the morning and evening of the 27th and 28th of November 2020. Pre-events will be also organized in summer and after the summer holiday if circumstances allow. One of the biggest will take place in the framework of Madrid Science and Innovation Fair that will organized from the 1st to the 15th of November 2020 to reinforce and prepare the coming Night. Sport competitions as pre-events will be held during September and October and another in December 2020 as post event, if circumstances allow.  
The activities will be addressed to public at large, science-addicts and science-reluctant, children, families, teachers, elderly, people regardless their scientific background with a special focus on young people: secondary and primary school students with the main purpose of encouraging STEM subjects and science careers, university students and also vocational education and training students. The event will involve researchers, other researchers benefited by EU funds, especially the Marie Skłodowska-Curie fellows, Regional and Academic authorities, stakeholders and managers from universities, research centres, museums, hospitals, NGOs, foundations and industry (Spin offs, SME or Large Companies) in the Region of Madrid.
Lucero - smart optofluidic micromanipulation of biological samples

The goal of Lucero is to create autonomous micromanipulation solutions for biological applications integrating optical manipulation, microfluidics, and machine intelligence. Single-cell analysis is critical in many biomedical applications, such as clinical trials, in-vitro fertilization, forensic analysis, and single-cell omics. In fact, it is an ideal moment to enter the single-cell analysis market, because this market is valued at $1.4 billion globally and expected to keep on growing with a compound annual rate higher than 17%. While some techniques are already commercially available, single-cell approaches still have several limitations. Mechanical tools (e.g., motorised micropipettes and microneedles, centrifugation) are invasive and prone to damage the cells. Labeled-sorting methods (e.g., flow-cytometry) can affect cell viability for subsequent protocols. Non-invasive sorting procedures based on microfluidics require high amounts of cells and numerous repetitions to obtain a significant fraction of target cells. Furthermore, in all cases these methods require expert handling and are labor intensive. With Lucero, we propose a solution that overcomes these problems based on a smart optofluidic platform: contactless thanks to the use of optical tweezers, capable of controlling the local cellular environment thanks to the use of microfluidics, and capable of autonomous and accurate operation thanks to machine intelligence. Lucero will be compatible with standard microscopes already available in biomedical laboratories, permit to completely automatize single-cell protocols, and therefore drastically lower the cost of biomedical research. Lucero already counts with an outstanding core team of scientists and experienced business people, and it will provide ~20 jobs to university-educated individuals in the EU within the next 5 years. Lucero has already received initial funding and support from two different organizations that support and believe in Lucero's venture.