SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Towards early molecular diagnostics of schizophrenia

Schizophrenia (SZ) is a severe mental disorder affecting more than 0.7% of the adult population. One of the most disabling and emotionally devastating illnesses known to man, SZ is also associated with considerable socioeconomic burden. In general, the chronic nature and the high degree of patient disability make SZ the fourth leading cause of disease burden across the globe with the management costs making up ~3% of the total healthcare budget in the Western countries. The situation is even direr in some regions, including northern Sweden and Finland, where relative prevalence of SZ exceeds two to three times corresponding national or regional averages. Poorly understood aetiology and limited diagnostic arsenal make it difficult to detect and treat SZ in a timely and efficient manner. This underscores a critical need for better understanding of the mechanisms underlying SZ and development of new diagnostic possibilities allowing its early detection, ideally prior to the onset of psychosis. The SZ_TEST will address these challenges by coordinating efforts with complementary areas of expertise in genetics, epigenetics, neurodevelopment, molecular psychiatry, clinical immunology and biotech R&D. The overarching hypothesis underlying our work is that genetic vulnerabilities, neurodevelopmental defects, exposure to pathogens, immune system status and specific lifestyle choices may compound the risk of SZ and that a systematic multivariate analysis of these factors should result in substantially improved diagnostic tools. SZ_TEST will work towards the development of molecular diagnostics tools for early detection of SZ, by using relevant cohorts of human subjects, unique animal and cell models, and combining unbiased high-throughput omic screens with knowledge-based candidate marker analyses. SZ_TEST training network is expected to have a major impact on improving the quality of life and reducing the health care costs in Europe and worldwide.
Heat-exchange rolls and method of calendering and rolling including controlling the temperature of such heat exchange rolls

861,188. Electrically heated rolls. FARREL -BIRMINGHAM CO. Inc. April 17, 1959 [May, 2, 1958], No. 13135/59. Class 39 (3). [Also in Group XXXV]. A heat-exchange roll for use in calenders or rolling mills comprises one or more electrical heating coils 28a within the body of the roll 20 and a channel is provided between the roll body and the internal sleeve 28 for supporting the heaters for the passage of cooling air under pressure. The temperature of the roll can then be regulated by control of the heating current and control of the air blower. This control may be in response to thermocouples 40 provided in the body of the roll, and a circuit is described for automatically maintaining the roll at a desired temperature. The air blower inlet is shown at 29, and the direction of the air flow is reversed at the end of the channel between sleeve 28 and the roll body 20, so that the air flows back through the sleeve 28 and out through the sleeve 30. The roll is mounted at each end in a journal 26 and the leads to the heaters and thermocouples are connected to slip rings. A heat-insulating washer 33 is provided at each end of the roll body 20. Three electrical heating coils 28a are provided side by side and three thermocouples 40 are provided, equally spaced around the roll, but extending different distances into the body of the roll in order to sense the temperatures at three different locations.
Fractional Fliess operators: Two approaches

A useful representation of an input-output map in a nonlinear control system is the Chen-Fliess functional series or Fliess operator. It can be viewed as a noncommutative generalization of a Taylor series, and its algebraic nature is especially well suited for a number of important applications. The objective of this paper is to describe a generalization of this class of operators, so called fractional Fliess operators. These are functional series whose coefficients have a certain fractional growth rate (Gevrey series) and whose iterated integrals are defined in terms of fractional integrals. The motivation for this idea is two-fold. First, fractional system theory is a well developed area with a variety of applications, so this concept is a natural generalization in its own right. But even in the classical case it has been observed that the cascade interconnection of two Fliess operators can result in a composite system that has a certain fractional nature. Hence, developing this generalization may also provide some insight into this issue.
Fifteen years of ultrasound guidance in regional anaesthesia: Part 2—Recent developments in block techniques

The use of ultrasound guidance for regional anaesthesia has gained enormous popularity in the last 10 yr. The first part of this review article provided information on safety, technical developments, economic aspects, education, advantages, needle guidance techniques, and future developments in ultrasound. The second part focuses on practical and technical details of individual ultrasound-guided nerve blocks in adults. We present a comprehensive review of the relevant literature of the last 5 yr with a commentary based on our own clinical experience in order to provide information relevant to patient management. Upper limb blocks, including interscalene, supra- and infraclavicular, and axillary approaches, are described and discussed. For the lower limb, psoas compartment, femoral, obturator, sciatic, and lateral cutaneous nerve blocks are described, as are some abdominal wall blocks. The potential role of ultrasound guidance for neuraxial block is addressed. The need for further large-scale studies of the role of ultrasound is emphasized.
Places of remembrance in muslim russia: islamic heritage and moral landscapes

The goal of this project is to map Islamic places of remembrance in Central Russia’s Volga region, and analyse their social, political, and affective life. The post-Soviet Islamic boom has raised acute concerns and generated debates on the place of Islam in Russia, home to an ancient Muslim community. So far, little fine-grained anthropological scholarship about Russia’s Muslim population has been produced. My project seeks to fill this gap in our knowledge by looking at the concrete places where the post-Soviet Islamic revival manifests itself. 
The past few years have witnessed the rediscovery – sometimes reconstruction – of numerous Islamic sites throughout the Russian Federation, along with the emergence of numerous locales where self-cultivation, ethnically inflected civic engagement, conflict, and compromise are played out by Muslims through the prism of remembrance. Anthropological methods of investigation shall be utilised to analyse how both institutional initiative and grassroots creativity are involved in the production of multi-scalar moral landscapes at the intersection of the nation-state, the ethnic community, and the ummah. Special attention will be devoted to social memory dispositifs, from institutional heritage projects to intimate practices of remembering. 
This project, built upon specialised skills and experiences I acquired as a graduate student, will offer fresh contributions to ongoing debates on post-socialist and Islamic personhood; memory, state-Muslim relations in Russia; and the spatial manifestations of religious life amongst Eurasian Muslims. This Fellowship will give me a unique chance to complete my maturation as a social scientist. At the Universities of Berkeley and Venice, I will undertake specialised training, broadening my area expertise, my methodological repertoire, and my theoretical competencies across disciplines such as social and historical anthropology, Russian studies, and Islamic studies.
Italian heritage, Italian legacy e Italian affection: la negoziazione dell’Italianità e dell’identità nei linguistic landscapes delle Little Italy nordamericane

Scopo dell’analisi qualitativa di stampo sociolinguistico in questa sede condotta è 1) l’osservazione delle varietà di lingua e dei fenomeni di contatto osservabili nei linguistic landscape delle Little Italy nordamericane di Boston, New York e Toronto e 2) la successiva correlazione dei fenomeni linguistici osservati alle categorie culturali-merceologiche Italian heritage, Italian legacy e Italian affection.
Mobility in situ: debating emigration and return in western mali

Located in Western Mali, at the junction with Senegal and Mauritania, the area of Kayes has a long history of sustained involvement in transnational migration, notably towards France. The region bears the material and social imprints of decades of international migration in its infrastructures, buildings, family relations, and local notions of success and failure. Though this migration and its social effects have been the topic of a wide range of studies, the local understandings and discussions of these dynamics have been under-researched. Dwelling on developments in anthropology and African studies that highlight the importance of local expressive practices, this project focuses on three arenas where emigration and, more specifically, return have been debated: a village created by returnees in 1977; a local radio initiated by emigrants in 1987; individual trajectories of returnees from France to one village. In each field-site, biographical narratives will be combined with corpora of local productions of distinct sorts: personal documents such as family letters or cassettes; public discourses such as listeners’ letters to the radio and songs; and personal archives including photographs. The project will discuss the issue of return, a heavily politically and morally loaded one, by bringing together the individual and collective stories of returnees from distinct generations (those returning as adults in the 1970s and those returning in the 2000s), and the public discourses of each time. It will also question the way it is currently memorialized. While contributing to anthropological discussions on return migration, the ambition of the project is also to offer a better understanding of a key zone of emigration to Europe. Since the European Union is committed to address the root causes of migration, and funds initiatives to prevent migration, providing knowledge on local debates on migration can offer resources for designing effective programs in this field.
SOVVENZIONE PER LA RIPRESA PRODUTTIVA A SEGUITO DI EMERGENZA COVID

LA DITTA SVOLGE ATTIVITÃ  DI RISTORAZIONE CON PREVALENTE CLIENTELA D'AFFARI. SI TRATTA DI UN' IMPRESA FAMILIARE CHE OCCUPA ANCHE LAVORATORI DIPENDENTI. L'ATTIVITÃ  ÃŠ STATA SOSPESA A CAUSA DELL'EMERGENZA COVID E NECESSITA DI ADEGUAMENTI ORGANIZZATIVI PER CONTINUARE IL NORMALE SVOLGIMENTO DELLA STESSA.
Performance analysis on adaptive control for security using Trust management using IOT in OSN

A social Internet of Things (IoT) framework can be seen as a blend of conventional distributed systems and informal communities, where things self-sufficiently set up social connections as per the proprietors' interpersonal organizations, and look for trusted things that can give administrations required when they come into contact with each other deftly. We propose and investigate the outline thought of versatile trust administration for social IoT frameworks in which social connections develop powerfully among the proprietors of IoT gadgets. We uncover the configuration tradeoff between trust merging versus trust variance in our versatile trust administration convention outline. With our versatile trust administration convention, a social IoT application can adaptively pick the best trust parameter settings in light of changing IoT social conditions such that trust evaluation is exact as well as the application execution is amplified. We propose a table-lookup technique to apply the investigation comes about powerfully and exhibit the plausibility of our proposed versatile trust administration plan with two certifiable social IoT administration arrangement applications.
Adaptive microfluidic- and nano-enabled smart systems for water quality sensing

Water management requires massive, low-cost monitoring means coping with differentiated and evolving requirements. However, the majority of multifunctional water sensors only supports predefined goals hindering interoperability, with a high cost, impeding large scale deployments. 
Addressing this, PROTEUS aims at offering x10 reduction in both size and unit function cost compared to state of the art. To this end, an increased number of functions will be integrated at a reduced cost and PROTEUS will deliver a reconfigurable microfluidic-and nano-enabled sensor platform for cognitive water quality monitoring. Innovative embedded software will provide reconfigurability of the sensing board to support several differentiated applicative goals while cognitive capabilities will manage evolving requirements during exploitation. Energy autonomy will be made by harvesting water flow energy. In addition, low cost of additional sensing components will enable redundancy increasing life span of the systems.
The main challenge relates to the heterogeneous integration into a monolithic, microfluidic sensing chip of carbon-nanotubes-based resistive chemical sensors, of MEMS physical and rheological resistive sensors and of a multifunctional adaptive deep-submicron CMOS system on chip. 
Upstream, high level system design addressing industrial use cases, manufacturability and cost-effectiveness, packaging, energy budget and interfaces between building blocks, will enable consistency and efficiency of the whole approach. 
Downstream, system validation will be carried out at different levels: benchmarking, reliability assessment to guarantee service time, model deployments and field testing.
The consortium brings together renowned actors along the whole value chain, including system integration and end users. This will contribute to post-project exploitation prepared by ensuring appropriate inclusion of business requirements within the system design.
Pj.19 w2 content integration, performance management and business case development

PJ19 W2 CI  is a transversal activity of the SESAR 2020 Programme in continuation of the SESAR Wave 1 PJ19 CI Content Integration project.
It aims to integrate the SESAR Solutions into the integrated European ATM System in order to achieve the objectives set by the ATM Master Plan (MP). This integrated European ATM System provides the overall European ATM concept, the high-level architecture options, the services, the supporting solutions, and the performance achievements associated with them. As such, PJ.19 W2 does not create any specific ATM concept or solution but produces a set of deliverables which consolidate the SESAR 2020 Programme outcomes and provides yearly integrated reference material – the SESAR 2020 Architecture release (EATMA version) . This is done in close collaboration and coordination with all SESAR 2020 Solutions and the SJU through continuous, rolling and iterative content integration.
PJ19-W2 allows the assessment of the overall performance of the SESAR Solutions compared with the performance improvements expected for the European ATM.
Whilst the decisions are made by SJU management and SESAR governance, PJ.19 W2 activities support and guide the processes (e.g. safety, security assessment, human performance, performance assessment, cost benefit analysis (CBA), architecture, requirements) to bring the SESAR Solutions together and assess their maturity (completeness, consistency and coherency) from a holistic perspective represented in the SESAR 2020 Concept of Operations. 
The PJ.19 W2 activities provide major inputs for the ATM MP production (ATM architecture information (e.g. data set), performance and CBA consolidation, business case production), which are further consolidated at the time of the ATM MP update campaign by the PJ.20 W2 ‘Master Planning’ project).
PJ19-W2 provides support for the SJU/SESAR governance decision-making and programme execution monitoring and also contributes to the realisation of the ATM MP.
~(13)C Solid-state Nuclear Magnetic Resonance Investigations of Gas Hydrate Structures

Solid State NMR spectroscopy has taken a very prominent place in many spectroscopic techniques employed for the characterization of clathrate hydrates.In this work,we have measured the synthesized ethane gas hydrates by 13C NMR with Magic Angle Spinning(MAS) and High Power 1H Decoupling(HPDEC) at 173 K and atmospheric pressure.Furthermore,we have got the 13C NMR spectra of ethane gas hydrates and propane gas hydrates,and preliminary established the testing method of natural gas hydrate by Solid State 13C NMR spectroscopy.The experimental results show that there is only one resonance line(δ 7.7×10-6) for ethane in the hydrate phase obtained from 13C NMR,while ethane molecules are enclathrated in the sⅠhydrates and only contained in the large cages(51262).The 13C NMR spectra of Propane gas hydrates exhibit tow resonance lines(δ 16.7 and 17.5),which are assigned to methyl carbons and methylene carbons,respectively.Consequently,the propane gas hydrates are determined to be sⅡ hydrates,and propane molecules are only trapped in the large cages(51264).
BUOYANCY DEVICE FOR MARINE STRUCTURES

Disclosed is a buoyancy device for tensioning an elongate vertical (or quasi vertical) subsea structure at a point below the sea surface, anchored at its bottom. The device comprises as its main buoyancy elements a plurality of hollow elongate objects, and further comprises at least one auxiliary buoyancy element comprising a solid buoyant material. Ideally, the solid buoyant material provides enough uplift to maintain the device afloat should the main buoyancy elements be flooded. A riser apparatus comprising such a buoyancy device is also described.
Industrial Symbiosis for Regional Sustainable Growth and a Resource Efficient Circular Economy

INDUSTRIAL SYMBIOSIS FOR A RESOURCE EFFICIENT ECONOMY:_x000D_
The SYMBI project brings together 9 partners from 7 countries, including 4 management authorities of territorial programmes, to diffuse industrial symbiosis and align regional policies with the circular economy package of the European Commission. SYMBI aims to support the transition towards a resource-efficient economy through the establishment of territorial synergies to manage waste and exchange energy & by-products as secondary raw resources._x000D_
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SYMBI will enable the participating regions to advance their goals for sustainable growth and job creation, since industrial symbiosis can lead to: a) considerable material savings, resulting in an increase of competiveness, b) new business models that involve revenue streams from secondary raw resources, and c) the mitigation of risks associated with the volatile global economy and proliferating signs of resource depletion._x000D_
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SPECTRUM OF POLICY INTERVENTIONS:_x000D_
The SYMBI project has been designed to support the exchange of experiences and increase the capacities of partners and stakeholders involved, taking into consideration their profiles and regional interests. To this end, SYMBI prescribes policy learning activities on the following regional intervention areas: a) waste management and transformation, b) public procurement, c) local taxation, and d) innovation programmes._x000D_
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WHAT WILL SYMBI DO:_x000D_
SYMBI will improve 8 policy instruments, relevant to the abovementioned policy areas; 6 of the managing authorities participate in the consortium, so as to secure the impact of the project. SYMBI activities will:_x000D_
- Incentivise regional waste transformation systems and cross-sectoral synergies,_x000D_
- Promote the use of secondary raw materials,_x000D_
- Prioritise green procurement,_x000D_
- Unlock investments by regional and local financial actors,_x000D_
- Explore, assess, expand, and enhance current practices in eco-systems of industrial innovation,_x000D_
- Build consensus between regional stakeholders._x000D_
Impact of Contextual Variables on Effectiveness of Partnership Governance Mechanisms in Megaprojects: Case of Guanxi

AbstractGovernance mechanisms are crucial to the success of joint-venture (JV) megaprojects. Although both contractual and relational governance mechanisms are studied to maximize cooperation and minimize opportunism, the relative effectiveness of each mechanism remains unclear, particular in JV megaprojects. Based on the transaction cost economics and relational exchange theory, this paper presents a case study of Chinese JV megaprojects to explore the impact of governance mechanisms in promoting cooperation and restraining opportunism. Specifically, this paper investigates how guanxi, as a contextual variable, affects effectiveness of different governance mechanisms when dealing with cooperation and opportunism in JV megaprojects. The analysis is based on data collected from 377 respondents. The findings suggest that guanxi plays an important role in affecting the effectiveness of partnership governance mechanisms in megaprojects. In the low guanxi scenario, both contractual and relational governance me...
COMPOSITIONS AND METHODS FOR TREATING DISEASE STATES ASSOCIATED WITH ACTIVATED T CELLS AND/OR B CELLS

Disclosed are combination therapies and related compositions that may contain one or more of a p53 potentiating agent, a DNA-damaging agent, an agent that inhibits cell cycle check point, and a pharmaceutically acceptable carrier. Also disclosed are methods of using such compositions for the treatment of conditions related to T cell and/or B cell activation in subjects in need of such treatment.
Global epidemiology of alcohol-associated cirrhosis and HCC: trends, projections and risk factors

Heavy alcohol consumption is a major cause of morbidity and mortality. Globally, alcohol per-capita consumption rose from 5.5 litres in 2005 to 6.4 litres in 2016 and is projected to increase further to 7.6 litres in 2030. In 2019, an estimated 25% of global cirrhosis deaths were associated with alcohol. The global estimated age-standardized death rate (ASDR) of alcohol-associated cirrhosis was 4.5 per 100,000 population, with the highest and lowest ASDR in Africa and the Western Pacific, respectively. The annual incidence of hepatocellular carcinoma (HCC) among patients with alcohol-associated cirrhosis ranged from 0.9% to 5.6%. Alcohol was associated with approximately one-fifth of global HCC-related deaths in 2019. Between 2012 and 2017, the global estimated ASDR for alcohol-associated cirrhosis declined, but the ASDR for alcohol-associated liver cancer increased. Measures are required to curb heavy alcohol consumption to reduce the burden of alcohol-associated cirrhosis and HCC. Degree of alcohol intake, sex, older age, obesity, type 2 diabetes mellitus, gut microbial dysbiosis and genetic variants are key factors in the development of alcohol-associated cirrhosis and HCC. In this Review, we discuss the global epidemiology, projections and risk factors for alcohol-associated cirrhosis and HCC.