SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Improving Range Query Result Size Estimation Based on a New Optimal Histogram

AbstractMany commercial relational Data Base Management Systems (DBMSs) maintain histograms to approximate the distribution of values in the relation attributes and based on them estimate query result sizes. A histogram approximates the distribution by grouping data into buckets. The estimation-errors resulting from the loss of information during the grouping process affect the accuracy of the decision, made by query optimizers, about choosing the most economical evaluation plan for a query. In front of this challenging problem, many histogram-based estimation techniques including the equi-depth, the v-optimal, the max-diff and the compressed histograms have well contributed to approximate the cost of a query evaluation plan. But, most of the times the obtained estimates have much error. Motivated by the fact that inaccurate estimations can lead to wrong decisions, we propose in this paper an efficient algorithm, called Compressed-V2, for accurate histogram constructions. Both theoretical and effective experiments are done using benchmark data set showing the promising results obtained using the proposed algorithm. We think that this algorithm will significantly contribute for helping to solve the problem of Multi-Query Optimization (MQO) resulting from queries interactions especially in Relational Data Warehouses (RDW) which represent the ideal environment in which complex OLAP queries interact with each other.KeywordsOptimal histogramsQuery result size estimationIntermediate query result distributionDBMSEstimation errorMulti-query optimizationQuery interaction
Two priority dimension order routing algorithm for virtualization of a network on chip design

A two priority dimension order routing(TPDOR) algorithm was developed foris communications in irregular topologies formed by virtualization of network on chip(NoC) designs.The TPDOR needs two bits per router to configurate two prior routing directions.The TPDOR can be used in two categories of topologies with three meshes connected in any way or with all the end-nodes communicating with the rest of the nodes through a minimal path defined in the original mesh topology.The algorithm connectivity is proven and the algorithm is shown to be free of dead locks.Simulations of the TPDOR in the field-programmable gate arrays(FPGA) of the EP2S180F1020C3 show that the area penalty is just 1.2% higher than the dimension order routing module,with negligible added cost.
New Insights into Cosmic-Ray-induced Biosignature Chemistry in Earth-like Atmospheres

With the recent discoveries of terrestrial planets around active M-dwarfs, destruction processes masking the possible presence of life are receiving increased attention in the exoplanet community. We investigate potential biosignatures of planets having Earth-like (N$_2$-O$_2$) atmospheres orbiting in the habitable zone of the M-dwarf star AD Leo. These are bombarded by high energetic particles which can create showers of secondary particles at the surface. We apply our cloud-free 1D climate-chemistry model to study the influence of key particle shower parameters and chemical efficiencies of NOx and HOx production from cosmic rays. We determine the effect of stellar radiation and cosmic rays upon atmospheric composition, temperature, and spectral appearance. Despite strong stratospheric O$_3$ destruction by cosmic rays, smog O$_3$ can significantly build up in the lower atmosphere of our modeled planet around AD Leo related to low stellar UVB. N$_2$O abundances decrease with increasing flaring energies but a sink reaction for N$_2$O with excited oxygen becomes weaker, stabilizing its abundance. CH$_4$ is removed mainly by Cl in the upper atmosphere for strong flaring cases and not via hydroxyl as is otherwise usually the case. Cosmic rays weaken the role of CH$_4$ in heating the middle atmosphere so that H$_2$O absorption becomes more important. We additionally underline the importance of HNO$_3$ as a possible marker for strong stellar particle showers. In a nutshell, uncertainty in NOx and HOx production from cosmic rays significantly influences biosignature abundances and spectral appearance.
Recurrence Plot Analysis of HRV for Exposure to Low-Frequency Noise

Previous studies have indicated that the chronic effects of exposure to low-frequency noise causes annoyance. However, during the past two decades, most studies have employed questionnaires to characterize the effects of noise on psychosomatic responses. This study investigated cardiovascular activity changes in exposure to low-frequency noise for various noise intensities by using recurrence plot analysis of heart rate variability (HRV) estimation. The authors hypothesized that distinct noise intensities affect cardiovascular activity, which would be reflected in the HRV and recurrence quantification analysis (RQA) parameters. The test intensities of noises were no noise, 70-dBC, 80-dBC, and 90-dBC. Each noise level was sustained for 5 min, and the electrocardiogram (ECG) was recorded simultaneously. The cardiovascular responses were evaluated using RQA of the beat-to-beat (RR) intervals obtained from ECG signals. The results showed that the mean RR interval variability and mean blood pressure did not substantially change relative to the noise levels. However, the length of the longest diagonal line ( L max ) of the RQA of the background noise (no noise) condition was significantly lower than the 70-dBC, 80-dBC, and 90-dBC noise levels. The laminarity showed significant changes in the noise levels of various intensities. In conclusion, the RQA-based measures appear to be an effective tool for exposure to low-frequency noise, even in short-term HRV time series.
Fuzzy modeling of diesel engine based on working position

The paper deals with a problem of nonlinear modeling of diesel engine. A nonlinear fuzzy model based on working position of diesel engine is proposed. The angular velocity of the engine was divided to several segments. For every area, a three-order equivalent linear model was identified with the Correlation Analysis-Least Square method. On the basis of the parameter of linear model, the fuzzy rules were founded. The identification results indicate that the fuzzy modeling method is effective and the nonlinear model is accurate. This nonlinear model can be used to design the control system of diesel engine, and understand its complex dynamics.
Port site hernia in laparoscopic surgery: Mechanism, prevention and management

Abstract Port site hernia (PSH) is a rare type of incisional hernia occurring at port sites after laparoscopic surgery. Larger trocar size and improper port site sheath closure are considered to be the most important predisposing factors. In many instances, this condition may be overlooked due to short follow-up of the patients after surgery, and lack of knowledge of clinicians about this clinical entity. This article is aimed to review the applied surgical anatomy related to PSH and trocar placement and the gradual evolution in the design of trocars. Herein, we have also discussed the burden of the disease, techniques for prevention, diagnosis and management of PSH.
Implementation of R & D results in KAMEL STEEL S.C.

The object of the Project is an initial investment related to the diversification of production and the placing on the market of a product that was not previously produced in the plant. As a result of the implementation of the project, a new product of its own brand – modular basket will be put on the market. The project will purchase, assemble and launch a new innovative production line, the assumptions of which were developed as a result of the project from the Bon innovation competition – RPMA.01.02.00-14-a743/18 – “R & D works on welding line elements” and a new product for the Company – transport basket – also developed as a result of the implementation of the project from the Bon innovation competition – RPMA.01.02.00-14-b086/18 “Development of industrial design in the framework of R & D works”. The implementation of an innovative, innovative production solution developed and implemented in close cooperation with the Scientific Unit will further strengthen the position of the Company throughout Europe. Implementation of the results will allow for rapid development, employment growth and improvement of Mazovia’s image as a leader in the metal industry. The investment will include construction- adaptation work necessary to set up a production line, which will include: connecting the robotic and laser station to the existing ventilation system and making the ventilation hood. Preparing the ground and anchors for the machines, pulling up the electrical system to the station, making the installation supplying the technological gases- to the robot and laser cutting machine. Purchase of fixed assets necessary for the implementation of R & D works, in particular: Robotic station, angle bevel device, frame welding instrument, eccentric press, press brake, laser cutting machine and necessary CIS for commissioning purchased fixed assets. The applicant has not yet started the project, but has only carried out preparatory work related to the development of the business plan and the estimation of the value of the purchases in the project.
How retrotransposons remodel the genome during early development and reprogramming

Retrotransposons (RTNs) are ancient viruses that have stably integrated themselves into mammalian genomes and they now occupy around half of the human or mouse genome. These mobile genetic elements that have coevolved with us drive evolution by creating new genes and plasticity of genomes. Exciting data including ours has shown that even RTNs that are no longer active retain enhancer, promoter or repressor sequences that regulate developmental genes, through largely uncharacterized transcription factors. We have employed CRISPR/Cas9 gene disruption to determine that Zfp37 and Zfp819 bind to and regulate RTNs in mouse embryonic stem cells (ESCs). Identification of these zinc finger proteins (ZFPs) now allows us to ask new questions about how RTNs have been co-opted to orchestrate gene circuits in vitro and in vivo. Both these factors have already been implicated to play a role in reprogramming or genome integrity. 

We hypothesize that RTNs have been co-opted to remodel the genome by acting as structural platforms that recruit transcription factors like Zfp37 and Zfp819. We will test this hypothesis assessing the role of RTNs and these two ZFPs in three dynamic contexts where the genome is remodelled. These are in ESC differentiation to neurons, in reprogramming and in early mouse development, three scenarios where RTNs have been documented to become expressed and serve an unknown function.

This work will exploit mouse development to unravel the mechanism of how RTNs remodel the genome. It will help us to understand how ZFPs can be engaged to reprogram cells and in stem-cell therapies, and will explain more broadly how RTNs, which dominate our genomes, control cell fate.
PUMP

A progressive cavity pump is provided, having a stator section and a rotor section axially aligned with and surrounded by the stator section, a drive shaft connection section and a suction chamber, arranged between the stator section and the drive shaft connection section; wherein the suction chamber is configured such that it can be disassembled without moving the stator section or the drive shaft connection section, thereby facilitating the performance of maintenance operations.
Identificación de las fake news que se publican en la edición en papel de un diario provincial en la era de la desinformación digital de Trump y el inicio del COVID

Las fake news se han convertido en un problema en la sociedad de la información generalista y debe su preeminencia, en buena medida, a la democratización de las redes sociales y a la polarización de fuerzas de distinto índole. Pero más allá de los canales digitales, existe un público, en este caso de corte local-provincial, que sigue las noticias como tradicionalmente ha hecho: principalmente a través de su diario de referencia, en papel. Este trabajo analiza, cuantitativa y cualitativamente, los contenidos relacionados con las fake news aparecidos en la versión impresa del Diario Información, entre el 3 de febrero de 2020, inicio de la campaña electoral en EE UU y la aparición del primer caso de coronavirus en España, dos hechos claros que conducen directamente a noticias en origen o destino falsas, hasta el 21 de enero de 2021, día este último siguiente al inicio de la era Joe Biden. El objetivo es intentar conocer si el acerbo debate y el protagonismo de las fake news en los canales digitales tienen un traslado proporcional a las páginas de este rotativo y si son temas prioritarios para la persona lectora. El estudio deja claro que frente al bombardeo y el ruido en torno a las fake news en el social media, en la prensa de papel predomina una reflexión sosegada, un análisis del problema y una denuncia clara y avalada en contra de este tipo de mensajes. Y lo que es más importante: casi no es noticia para el papel.
Foreword: Eukaryotic DNA replication: is time of the essence?

The visionary studies of Watson and Crick (1953) first proposed a structure for DNA to suggest a ‘possible copying mechanism for the genetic material’. Ever since, cell biologists have marvelled at the mysteries by which this most fundamental process of cell proliferation is controlled. The importance of mechanisms that regulate DNA synthesis is selfevident, given the biological imperative to maintain genetic integrity from one cell generation to the next. Moreover, in order to preserve the genetic information, it is essential that synthesis is performed with absolute precision, as any errors might generate chromosomal defects, which can ultimately lead to cell transformation or death. As is often the case in biology, our desire to understand how a synthetic process might fail demands a molecular understanding of that process under normal conditions. In eukaryotes, a molecular description of the replication machinery and basic mechanisms that regulate synthesis have been developed using biochemical analysis of yeast (Waga and Stillman 1998) and Xenopus (Chong et al. 1995) extracts as model systems. These studies have elaborated the key components of the synthetic machinery, the make-up of the origin recognition complex that defines where synthesis can begin and the role of the MCM2-7 complex that acts to ‘license’ DNA for replication and ensure that each potential origin is only able to operate once per cell cycle. At this level, essentially, the same basic machinery is used throughout eukaryotes. However, while this basic synthetic machinery is now well characterised, many of the mechanisms that control the synthetic process remain enigmatic. This is particularly evident in higher eukaryotes, where increasing organismal complexity and associated increases in genome size place huge demands on the need to perform replication with absolute precision. In higher eukaryotes, epigenetic histone modifications that fix patterns of gene expression during cell specialisation must also be recapitulated during DNA synthesis. Perhaps as part of this process, the mammalian S phase is known to be organised in time so that gene-rich chromosomal R-bands are replicated early in S phase before synthesis of the gene-poor G-bands can begin (Drouin et al. 1994). Put in these simplistic terms, it is easy to see why a temporally structure S phase programme must be a fundamental feature of the eukaryotic S phase. Yet, despite this Chromosome Research (2010) 18:1–5 DOI 10.1007/s10577-009-9106-2
TRAIL-receptor preferences in pancreatic cancer cells revisited: Both TRAIL-R1 and TRAIL-R2 have a licence to kill

TRAIL is a potent and specific inducer of apoptosis in tumour cells and therefore is a possible new cancer treatment. It triggers apoptosis by binding to its cognate, death-inducing receptors, TRAIL-R1 and TRAIL-R2. In order to increase its activity, receptor-specific ligands and agonistic antibodies have been developed and some cancer types, including pancreatic cancer, have been reported to respond preferentially to TRAIL-R1 triggering. The aim of the present study was to examine an array of TRAIL-receptor specific variants on a number of pancreatic cancer cells and test the generality of the concept of TRAIL-R1 preference in these cells.TRAIL-R1 and TRAIL-R2 specific sTRAIL variants were designed and tested on a number of pancreatic cancer cells for their TRAIL-receptor preference. These sTRAIL variants were produced in HEK293 cells and were secreted into the medium. After having measured and normalised the different sTRAIL variant concentrations, they were applied to pancreatic and control cancer cells. Twenty-four hours later apoptosis was measured by DNA hypodiploidy assays. Furthermore, the specificities of the sTRAIL variants were validated in HCT116 cells that were silenced either for TRAIL-R1 or TRAIL-R2.Our results show that some pancreatic cancer cells use TRAIL-R1 to induce cell death, whereas other pancreatic carcinoma cells such as AsPC-1 and BxPC-3 cells trigger apoptosis via TRAIL-R2. This observation extended to cells that were naturally TRAIL-resistant and had to be sensitised by silencing of XIAP (Panc1 cells). The measurement of TRAIL-receptor expression by FACS revealed no correlation between receptor preferences and the relative levels of TRAIL-R1 and TRAIL-R2 on the cellular surface.These results demonstrate that TRAIL-receptor preferences in pancreatic cancer cells are variable and that predictions according to cancer type are difficult and that determining factors to inform the optimal TRAIL-based treatments still have to be identified.
Effects of silt loading on turbulence and sand transport

Abstract The transport of bed material and fluid turbulence are affected by many factors, including the fine sediment load being carried in a channel. Current research has focused on sand-sized particles introduced to gravel beds, while the effect of silt load on sand transport has received less attention. Experiments on the effects of silt load, in concentrations 0-26,900 mg l −1 , on sand transport were performed with a recirculating laboratory flume using three different sand bed configurations: ripples ( Fr =0.24), dunes ( Fr =0.34), and dunes ( Fr =0.48). Three Acoustic Doppler Velocimeters were arranged to measure flow and turbulence quantities simultaneously in one vertical. Sand transport did not change in a consistent manner with increasing silt load, increasing up to 4,000 mg l −1 for dunes ( Fr =0.48) and up to 2,000 mg l −1 for dunes ( Fr =0.34) and then declining to near the clear water case with increasing silt concentrations. Silt addition for the ripple case caused a relatively small change in sand transport, decreasing with added silt up to approximately 2,000 mg l −1 and then increasing as silt went up to approximately 10,000 mg l −1 . Dunes ( Fr =0.48) decreased in length and height as silt increased, while dunes ( Fr =0.34) did not show a consistent trend. A clear trend of decreasing Reynolds stress with increasing silt concentration was observed in the ripple case, with a 33% reduction in near-bed Reynolds stress caused by an 8,900 mg l −1 concentration of silt.
Kunak sensing anywhere, an ultra-energy-efficient wireless critical system for smart environmental monitoring

Companies and other organizations need to monitor different parameters related to ""air, water and land"". Some organizations need to monitor these parameters to control potential pollution (Smart cities and polluting industries), while other organizations monitor the parameters to manage certain assets (cycle water management companies, utility companies, etc.). Outside of the plants where the Industry 4.0 is developing, it is not possible to have these variables controlled except by deploying extremely expensive solutions and/or with a great environmental impact (cabling, civil works, new infrastructures).

Kunak is an innovative solution to deploy wireless monitoring systems whose ultra-energy efficiency characteristics and end-to-end critical system architecture (from the environmental data analysis device to the platform cloud) provide great advantages in isolated, remote and complex environments, guaranteeing the robustness and integrity of 24/7 communications, which makes it a globally unique solution.

The new Kunak system measures the main greenhouse gases that have direct effects on climate change. In regard to the monitoring of air quality, Kunak solution is unique because it monitors air quality with the same accuracy as official stations with small scale devices at a cost 60 times lower.

Kunak has been successfully implemented with more than 30 clients. We have received 9 letters of interest, highlighting two from the largest companies included in the world’s top sustainability indexes.  Following the market survey conducted in SME Instrument Phase 1, we decided to extend the innovation project in Phase 2 with several technological improvements, testing activities and preparing for large scaled commercialisation of our Kunak System.

The important advantages provided by Kunak compared to current solutions will make it easier for us to be leaders in the new market that is emerging and to fulfil our mission: “Kunak utilises IoT to save the environment”.
Junior leader la caixa postdoctoral fellowship programme: shaping the new generation of leaders in research

""la Caixa"" Foundation (LCF) is a Spanish private foundation with a solid tradition as an innovative institution. LCF ranks among the top 10 world foundations considering either endowment or annual budget. LCF fellowship framework programme has awarded 4,771 fellowships since 1982.
Junior Leader is an existing LCF fellowship programme addressed to excellent experienced researchers of all nationalities willing to join one of the outstanding research centres in Spain or Portugal in the STEM areas (Science, Technology, Engineering and Mathematics). 
Junior Leader aims to train a new generation of researchers to become independent leaders, oriented towards both academia and industry, that will help to develop the European knowledge economy. 
LCF now is seeking support from the COFUND action with the aim to strength Junior Leader programme and the professional career development of the fellows. Thanks to the COFUND support, LCF will be able to enlarge the existing programme of 44 fellowships by adding 16 more fellowships, offering fellows an outstanding, more complete training as well as more networking possibilities thanks to a new secondment scheme. 
Junior Leader will award 60 fellowships divided into two calls. The programme will have a duration of 60 months. Fellows will freely propose a research project to be carried out at one of the 110 Spanish and Portuguese research centres certified as excellent  that collaborate with the programme. 
Researchers will be selected by means of an open, transparent and merit-based three-stages selection process with independent evaluators. Junior Leader fellows will be offered 3-year employment contracts with the host organisation of their choice following a bottom-up approach.
SURGICAL POSITIONING DEVICE AND APPARATUS

A surgical positioning device (12) comprises a securing assembly (16), a locating arrangement (18) securable to the securing assembly in a selected position of the locating arrangement, and an indicating arrangement (20) securable to the securing assembly in a selected position of the indicating arrangement. The locating arrangement comprises a locating member (40) to locate the positioning device in a desired orientation relative to a first article. The indicating arrangement further comprises indicating means (50) to indicate the position of a second article relative to the first article.