SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Toward the comprehension of primary bioelectromagnetic interactions: real time non-linear optical imaging of bio-samples under electromagnetic exposure

Cell membrane permeabilization, involving its reversible or irreversible restructuring, under extremely short electric (E) pulses exposure (from hundreds of us down to few ns) has a key role in a number of clinical, preclinical, and medical research applications. Hence, the knowledge of its bio-physical nature and dynamics (i.e. formation and resealing processes) is crucial for an aware control of delivered protocols, and for predicting treatments efficacy under established biological (e.g. buffer conductivity, cell dimensions) and electromagnetic (EM) conditions (e.g. pulse duration, amplitude, shape). To understand bio-physical mechanisms underlying such a pulse-exposure permeabilization, an innovative and advantageous approach is proposed based on real-time molecular vibrational modes imaging using fast Coherent anti-Stokes Raman Scattering (CARS) of in vitro samples under such a stimulation. Hence, in the present Marie Sklodowska Curie Action (MSCA), a fast CARS microscope will be integrated with a suitable wide band in vitro electromagnetic field (EMF) exposure setup to study the role of membrane lipid reactions and interfacial water in the electropermeabilization phenomenon. This innovative CARS analysis will be supported by mass spectroscopy measurements to verify the appearance of corresponding chemical species, and by simulated E field and pore density distributions on the bio-samples. This last step is an attempt to correlate sample areas presenting the highest CARS signal intensity with the correspondent E field and pore density distributions. The program that integrates engineering, physics, chemistry and biology will allow a substantial progression in my career and network ability through the work on a completely innovative, multidisciplinary and inter-disciplinary subject in one of the most reputed bioelectric laboratory, where the applications of electropermeabilization in biology and medicine where first developed in Europe and worldwide.
Practice and awareness of physicians regarding casual-clinic blood pressure measurement in Japan

The optimal procedure for casual-clinic blood pressure (CBP) measurement is outlined in the 2004 Japanese guidelines. We investigated the status of physicians' practices and their awareness of CBP measurement immediately and 4 years after the publication of the guidelines using a questionnaire regarding CBP. This survey was conducted among physicians who attended educational seminars on hypertension in 2004-2005 and in 2007-2008; the questionnaire was distributed, completed and collected just before the start of the seminars. Of the 1966 respondents to the 2004-2005 survey and the 2995 respondents to the 2007-2008 survey, the proportion of physicians who answered that CBP was more important than self-measured BP at home (home BP) was less than 10% in both surveys. The proportion of physicians who used a mercury sphygmomanometer (68.1-75.5%) was higher than those who used an automatic and electronic sphygmomanometer (20.7-29.0%) in both surveys. However, the use of an automatic and electronic sphygmomanometer slightly increased from 20.7% in 2004-2005 to 29.0% in 2007-2008. Physicians who were younger or working in a hospital were less likely to measure CBP using the conditions of the guidelines. Approximately 50% of physicians correctly recognized the reference values of hypertension based on CBP measurement (systolic/diastolic, 140/90 mm Hg) in both surveys. The status of physicians' practice and awareness of CBP measurement varied by physicians' age, specialty and work place and those situations did not change over 4 years, underlying the importance of clarifying factors inherent in these situations.
Petrology and petrogenesis of Kamtal Intrusion Eastern Azarbaijan, NW Ian

The Kamtal Intrusion is located in Eastern Azarbaijan province, northwestern Iran, near the Armenian border. This body consists of an acidic part of monzogranitic composition, and an intermediate-basic part which is composed of quartz-monzonite and gabbro. The gabbro forms lenses within the intermediate rocks. Monzogranite has been intruded into the quartz-monzonite. Both monzogranites and quartz-monzonites are high-K calk-alkaline and metaluminous in composition and can be classified as I-type granitoids, while the gabbro has tholeiitic affinity. Monzogranite and quartz-monzonite are characterized by LREE-rich patterns and high LREE/HREE ratios. The similarities of their REE patterns suggest a genetic relationship among these rocks. The geochemical characters of the gabbro types indicate two different patterns: a flat pattern with low LREE/HREE ratio, and a steep pattern with high LREE/HREE ratio. The former was probably produced by high melting ratio of a depleted mantle source, and the steep pattern probably was the result of a low melting ratio of this mantle source. Negative anomalies of Nb and Ti can be seen in all rock types of the Kamtal Intrusion, which is indicative of subduction zones. The comparison of trace element variations with granitoid rocks of different tectonic settings allows observing a similarity between the Kamtal Intrusion and Andean volcanic arc granitoids. The Kamtal body is related to the VAG tectonic setting and was probably produced as a result of Khoy back-arc basin subduction beneath the Azerbaijan continental crust.
Exosomes for regenerative, immunosuppressive, neuroprotective, and oncosuppressive therapies

Exosomes (EV) are small vesicles ensuring transport of molecules between cells throughout the body. EVs contain specific signatures and have been shown to strongly impact on the fate of recipient cells. Their small size (<1μm) plus biological and physical functions make them perfect candidates as therapeutic agents in several fields (e.g. immune therapy, cell-free regenerative medicine, etc). Despite their great potential for biomedicine, there is still a lack of standards for EV isolation and quantification. In addition, specific in vitro potency assays are required to better predict their potential therapeutic activity. There is no rational set of criteria available so far to design synthetic EVs for specific clinical tasks. _x000D_
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Networking and cooperation of research&clinical centers of scientific excellence from transnational area is therefore essential to address these issues. Within EXOTHERA, we plan to develop an integrative approach that allows correlating physical and molecular properties of EVs with their function and therapeutic role. As short-term goals we will define best protocols for EV purification, quantification and sorting, characterize EVs physically and chemically, study their interaction with recipient cells, and establish a comprehensive correlation among all these properties, with_x000D_
the long-term view of optimizing EV-based therapeutic strategies in three relevant clinical frameworks: pseudoarthrosis&bone fracture healing, glioblastoma and spinal cord injury.
Jr Fiere Internazionali 2019-2022 — LOTRIČ d.o.o.

Performance individuale alla Fiera Internazionale 33. Control (International Trade Fair for Ouality Assurance) dal 7 maggio 2019 al 10 maggio 2019
Virome ngs analysis of  pests and pathogens for plant protection

Next generation sequencing (NGS) technology has proved to be pivotal for elucidating the complexity and the role of the microbiome associated with plant and animals. The role of the “virome” as a sub-component of the microbiome is beginning to be unveiled because of new ways to analyse the data and in recognition of its importance in shaping biological systems. The aim of VIROPLANT is to apply NGS technology and empirical biological experiments to develop new environmentally friendly virus-based control strategies to manage bacterial, fungal and insect vector-transmitted diseases (phytoplasmas and viruses) as well as insect pests. So far, plant protection through viruses has relied on limited successful model systems, such as baculoviruses for lepidopterans, and one mycovirus for the control of chestnut blight; moreover, viruses infecting bacteria (phages) are also state of the art tools with potential to cope with antibiotic resistant bacterial strains in human and veterinary medicine. VIROPLANT will create a database of new viruses (and virus derived biotechnological products) to increase the arsenal for the control of plant diseases caused by the most important biotic stresses. Different NGS and bioinformatics approaches will be applied to explore the virome diversity, including latent infections that can be potentially exploited for new biocontrol strategies. Protocols of risk assessment will be implemented for virome-based model control strategies. VIROPLANT will address the social and gender-specific perception of the use of virome-based techniques as alternatives to traditional pesticides. A business plan for representative categories of virome-based control strategies will be included. Small and medium enterprises and stakeholders will be involved in bringing the most promising products to the market. The consortium will cover experts in insect virome, phage therapy and mycoviruses from different agro-ecological systems throughout Europe.
Adaptive optical microscopy systems: unifying theory, practice and applications

Recent technological advances in optical microscopy have vastly broadened the possibilities for applications in the biomedical sciences. Fluorescence microscopy is the central tool for investigation of molecular structures and dynamics that take place in the cellular and tissue environment. Coupled with progress in labeling methods, these microscopes permit observation of biological structures and processes with unprecedented sensitivity and resolution. This work has been enabled by the engineering development of diverse optical systems that provide different capabilities for the imaging toolkit. All such methods rely upon high fidelity optics to provide optimal resolution and efficiency, but they all suffer from aberrations caused by refractive index variations within the specimen. It is widely accepted that in many applications this fundamental problem prevents optimum operation and limits capability. Adaptive optics (AO) has been introduced to overcome these limitations by correcting aberrations and a range of demonstrations has shown clearly its potential. Indeed, it shows great promise to improve virtually all types of research or commercial microscopes, but significant challenges must still be met before AO can be widely implemented in routine imaging. Current advances are being made through development of bespoke AO solutions to individual imaging tasks. However, the diversity of microscopy methods means that individual solutions are often not translatable to other systems. This proposal is directed towards the creation of theoretical and practical frameworks that tie together AO concepts and provide a suite of scientific tools with broad application. This will be achieved through a systems approach that encompasses theoretical modelling, optical engineering and the requirements of biological applications. Additional outputs will include practical designs, operating protocols and software algorithms that will support next generation AO microscope systems.
Analysis of Unemployment Issues and Employment Policy of the Youth after Financial Crisis——Survey on Western Countries after 2008 and Its Enlightenments

The economic crisis which began in 2008 has started to ease,but the influence of the crisis on the employment of the youth is significant,in many countries,the unemployment rate of the youth is not lowered with the recovery of the economy.Many governments in the crisis make a series of policies boost the employment of the youth and maintain the connection of the unemployed youth with labor market.This paper examines the status of the employment of the youth in different countries in the crisis and after the crisis and hopes to use the research on the reasons for the unemployment of the youth and employment policy of the youth in different countries to find its features and to enlighten China's employment policy of the youth.
Self-adjusting control for multi robot team by the network operator method

The problem we research is to construct such control function that autonomously provides control commands upon the received values of the object's state. We formulated mathematically the problem of control synthesis. The goal of synthesis is to find a multidimensional control function that depends on the current states of all objects. The synthesized control function adjusts any time the optimal control values to allow each robot achieving the objectives with the best quality functional value. The network operator method is used to solve the problem. The effectiveness of the proposed method is demonstrated in simulations on a team of two mobile robots performing a parking task.
Characteristics of individual reactions of the cardiovascular system of healthy people to changes in meteorological factors in a wide temperature range

Based on the results of 4-year observations of daily variations in blood pressure (BP) and heart rate (HR) in seven healthy volunteers, two distinct types of reaction of physiological indicators (PIs) to changes in meteorological parameters (first and foremost, atmospheric temperature T
 atm) are revealed. The first type is a monotonic (but nonuniform with respect to speed) decrease in systolic BP with increasing temperature, which is most pronounced for T
 atm < −5°C and T
 atm > 15°C, with a weaker reaction of diastolic BP and no reaction of HR (in four volunteers). The second type is a two-phase nonmonotonic dependence of BP indicators on T
 atm, which coincides with the first type in the range T
 atm < −5°C and is characterized by a positive correlation of BP and HR indicators with T
 atm for T
 atm > −5°C (in two volunteers). The physiological mechanisms that can provide the observed compensatory-adaptive reactions of healthy individuals to atmospheric factors in different temperature ranges are analyzed in detail. It has been shown that the revealed regularities can explain the results obtained by the authors in earlier studies.
Small bodies: near and far

We propose a benchmark study that will address critical points in reconstructing physical and thermal properties of near-Earth, main-belt, and trans-Neptunian objects. The combination of the visual and thermal data from the ground and from astrophysics missions (like Herschel, Spitzer and Akari) is key to improving the scientific understanding of these objects. The development of new tools will be crucial for the interpretation of much larger data sets from WISE, Gaia, JWST, or NEOShield-2, but also for the operations and scientific exploitation of the Hayabusa-2 mission.
Our approach is to combine different methods and techniques to get full information on selected bodies: lightcurve inversion, stellar occultations, thermo-physical modeling, radiometric methods, radar ranging and adaptive optics imaging. The applications to objects with ground-truth information from interplanetary missions Hayabusa, NEAR-Shoemaker, Rosetta, and DAWN allows us to advance the techniques beyond the current state-of-the-art and to assess the limitations of each method. The SBNAF project will derive size, spin and shape, thermal inertia, surface roughness, and in some cases even internal structure and composition, out to the most distant objects in the Solar System.  
Another important aim is to build accurate thermo-physical asteroid models to establish new primary and secondary celestial calibrators for ALMA, SOFIA, APEX, and IRAM, as well as to provide a link to the high-quality calibration standards of Herschel and Planck.
The target list comprises recent interplanetary mission targets, two samples of main-belt objects, representatives of the Trojan and Centaur populations, and all known dwarf planets (and candidates) beyond Neptune. Our team combines world-leading expertise in different scientific areas in a new European partnership with a high synergy potential in the field of small body and dwarf planet characterization, related to astrophysics, Earth, and planetary science.
Fingerprinting Blue Carbon: Rationale and Tools to Determine the Source of Organic Carbon in Marine Depositional Environments

Blue carbon is the organic carbon in oceanic and coastal ecosystems that is captured on centennial to millennial timescales. Maintaining and increasing blue carbon is an integral component of strategies to mitigate global warming. Marine vegetated ecosystems (especially seagrass meadows, mangrove forests, and tidal marshes) are blue carbon hotspots and their degradation and loss worldwide have reduced organic carbon stocks and increased CO2 emissions. Carbon markets, and conservation and restoration schemes aimed at enhancing blue carbon sequestration and avoiding greenhouse gas emissions, will be aided by knowing the provenance and fate of blue carbon. We review and critique current methods and the potential of nascent methods to track the provenance and fate of organic carbon, including: bulk isotopes, compound-specific isotopes, biomarkers, molecular properties, and environmental DNA (eDNA). We find that most studies to date have used bulk isotopes to determine provenance, but this approach often cannot distinguish the contribution of different primary producers to organic carbon in depositional marine environments. Based on our assessment, we recommend application of multiple complementary methods. In particular, the use of carbon and nitrogen isotopes of lipids along with eDNA have a great potential to identify the source and quantify the contribution of different primary producers to sedimentary organic carbon in marine ecosystems. Despite the promising potential of these new techniques, further research is needed to validate them. This critical overview can inform future research to help underpin methodologies for the implementation of blue carbon focused climate change mitigation schemes.
Molecular Diagnosis of CSF Virus Isolated from Indian Origin

This case study describes the detection of Classical Swine Fever (CSF) in Karnataka state, India during the year 2009-10.Three cases of acute mortality in small-scale pig farming units were investigated. In all the cases, affected pigs were not vaccinated against CSF. Constant pyrexia, dyspnoea, anorexia, lethargy, conjunctivitis, hyperaemia of the ears and convulsions were the primary clinical signs observed in all the cases. Clinical signs and necropsy findings suggested an early presumptive diagnosis of CSF. Presumptive diagnosis was further strengthened by molecular diagnosis by specific amplification of the 5' UTR region of the virus by subjecting pooled tissue materials to one-step RT-PCR. Strengthening the presumptive diagnosis by the aid of molecular diagnostic techniques is important not only to prevent the spread of the disease but also to evolve suitable strategy to control the disease.
New insight into the analysis of amniotic fluid microflora using 16S rRNA gene sequencing

Introduction:
Intra-uterine infection is a major cause of spontaneous pre-term birth before 30 weeks of gestation. In addition, intra-amniotic inflammation is present in approximately 80 % of patients with acute cervical insufficiency. The microbiome is known to cause intra-amniotic infection causing pre-term birth. Recently, surveys of the microbial communities in the vagina or in amniotic fluid using sequencing of the 16s rRNA gene have been carried out. Here, we reported the microbiome compositions in mid-trimester amniotic fluids in two pregnant women with cervical insufficiency identified using 16S rRNA sequencing.
Case presentation:
A 35-year-old primipara and a 37-year-old nullipara were admitted to Hallym University Medical Center, Korea. They were negative for nitrazine and Actim PROM (Medix Biochemica) tests, and their amniotic membranes had prolapsed beyond the external os. A physical examination indicated that cerclage using a uniconcave balloon should be carried out, and amnioreduction was performed. Thereafter, they delivered at very early pre-term birth of below 24 weeks and the birth outcomes were pre-natal death. Analysis of mid-trimester amniotic fluids in these two pregnant women with cervical insufficiency identified Sneathia sanguinegens and Fusobacterium nucleatum. These bacteria were not identified using vaginal or amniotic cultures.
Conclusion:
These results suggest that 16S rRNA gene sequencing can be used to identify the predominant microbiome causing pre-term birth in pregnant women with cervical insufficiency. Further studies are needed in large samples to improve our understanding of microbes causing pre-term birth and to prevent pre-term birth in pregnant women with cervical insufficiency.
RING ELEMENT HAVING A DIVIDED BASE FOR A LASHING OR ATTACHMENT MEANS

The invention relates to a ring element (1) for a lashing or attachment means (40), comprising a base (10) and a ring segment (2), which is closed oppositely to the base (10) and which spans a ring opening (4). According to the invention, in order to be able to simply attach, in particular, loop-shaped cables or bands, but also attachment means such as shackles, master links, and eye hooks, the base (10) is divided by an attachment channel (8) extending into the ring opening (4). A closure element (42), which is designed in such a way that the closure element can be inserted into the attachment channel (8), ends preferably flush with the base (10).
Appetite for Power: The Anglo-SaxonRegina Gratia Dei

This article discusses the political functions of Anglo-Saxon queens by analysing several royal consorts within their socio-historical and political context. While early Anglo-Saxon queens were seen as instrumental during the Conversion, it was only with the increasing focus on a king's legitimacy, that the importance of the queen was acknowledged. Cynethryth of Mercia, wife of Offa, was the first queen who can be said to have directly participated in her husband's divine ministry by signing his charters with a gratia-Dei formula. The examples further show that while kings inherited their power from their predecessors, queens had to carve out their role anew.