SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Reduction of microbial biofilm formation using hydrophobic nano-silica coating on cooling tower fill material

A cooling tower is a heat removal device, which extracts waste heat to the atmosphere through the cooling of a water stream to a lower temperature. Cooling towers are frequently associated with biofilm problems and Legionnaires disease outbreaks. Where biofilms can cause clogging and corrosion, reduction of biofilms is important for operational reasons and public health. Therefore, effective anti-biofilm strategies are needed in practice. The aim of the present study was to reduce biofilm formation using a nano-hydrophobic coating on cooling tower fill materials - polypropylene cooling tower fill material was coated with nano-silica. The effectiveness of the hydrophobic coating was investigated for a 6-month test period in a model cooling tower system, by monthly counting of the surface-associated bacteria using an epifluorescence microscope. A significant reduction (up to 4 log) in surface-associated bacteria was observed on coated test samples in comparison to uncoated control coupons. This study is the first report regarding the use of nano-silica coatings on cooling tower fills. The coating can be easily fabricated and the range of possible applications can be expanded to include a variety of conditions.
Rui Azevedo Digital Strategy 4.0

The priority objective of the Rui Azevedo Digital Strategy 4.0? project is to define a strategy for the digital promotion of its activity. We want to make Rui Azevedo a reference company in the use of new online trading channels.
Properties of damped Ly α absorption systems and star-forming galaxies in semi-analytic models atz = 2

We investigate predictions from semi-analytic cosmological models of galaxy formation for the properties of star-forming galaxies (SFGs) and damped Ly α absorption systems (DLAS), and the relationship between these two populations. Our models reproduce fairly well the observed distributions of redshift, stellar mass, star formation rate (SFR), and dust extinction for z ˜ 2 SFGs. We predict that DLA hosts span a broad range of properties, with broad and relatively flat distributions of stellar and halo mass, SFR, and luminosity. The photometric colours of DLA host galaxies trace the colours of galaxies with similar luminosities, but the majority are much fainter than the limits of most existing surveys of SFGs. Generally, DLA host galaxies and SFGs at z = 2 follow similar trends between stellar mass, DLA cross-section, cold gas fraction, SFR, metallicity, and dust extinction as the global population of galaxies with the same stellar mass. Since DLAS select galaxies with larger cold gas masses, they tend to have larger cold gas fractions, lower metallicities, higher SFRs, and less dust extinction than galaxies at the same stellar mass. Our models reproduce the observed relations between impact parameter, column density, and metallicity, suggesting that the sizes of the gas discs giving rise to DLAS in our models are roughly correct. We find that molecular fractions and SFRs are in general significantly lower at the location of the DLA line of sight than the galaxy-averaged value.
Intercoat

En el camino de fortalecimiento de la internacionalización, la empresa concibió un proyecto con un amplio conjunto de acciones, abarcando varias tipologías, con el objetivo de identificar nuevos clientes y oportunidades y, por lo tanto, lograr el citado fortalecimiento de su desempeño internacional.
New Strategies for Enzyme Replacement Therapy for Lysosomal Storage Diseases

Enzyme replacement therapy is an established means of treating lysosomal storage diseases. Infused enzymes are normally targeted to the lysosomes of affected cells by interactions with cell-surface receptors that recognize carbohydrate moieties such as mannose and mannose 6-phosphate on the enzymes. Therefore, we have investigated alternative strategies to deliver the lysosomal enzyme beta-glucuronidase in the enzyme-deficient mucopolysaccharidosis type VII mouse model. Here we summarize our recent efforts to use nontraditional ways to deliver beta-glucuronidase. First, we used a chimeric protein of the insulin-like growth factor II (IGF-II) fused to beta-glucuronidase to deliver enzyme via the IGF-II binding site on the bifunctional IGF-II/mannose 6-phosphate receptor. Second, we used the 11-amino-acid human immunodeficiency virus (HIV) Tat domain fused to beta-glucuronidase to mediate uptake by absorptive endocytosis. Interaction with heparan sulfate on the cell surface internalizes and delivers the Tat-tagged enzyme to the lysosome via plasma membrane recycling. Third, we created a chimeric beta-glucuronidase fused to the Fc portion of human immunoglobulin G (IgG) Fc, which was transported by the neonatal Fc receptor from the maternal circulation across the placenta to sites of storage in fetal tissues. Finally, periodate treatment was used to eliminate interaction with carbohydrate receptors, creating an enzyme with increased plasma half-life, resulting in transport across the blood-brain barrier and clearance of storage in neurons. These strategies for delivering lysosomal enzymes could also be used to target nonlysosomal proteins or enzymes identified for bioremediation of other conditions.
Launch platform – “Unicorn Hub”

The aim of the project is to create the “Unicorn Hub” Home Platform, which will support the development of innovative startups through a comprehensive incubation program. The applicant and Animator of the Start Platform is the Polish Foundation for Economic Development Assistance Centres “OIC Poland” in Lublin, with extensive experience in the implementation of projects in the area of entrepreneurship and innovation. The “Unicorn Hub” platform, through a unique ecosystem involving university cooperation, VC funds, SMEs and large companies, IOB and local government units, assumes support for start-ups from IT/ICT, Medicine/Public Health, Smart city (including Transport and Automotive) interested in launching business in Eastern Poland. The incubation programme within the Unicorn Hub Platform assumes an individual and unique model of action at two levels: a) design-operational (project milestones, formal elements, documentation of cooperation, preparation of cyclical/final reports describing the progress of companies, etc.), b) substantive and development (project development and project team development, achievement of subsequent product versions as a result of iterative approach, experimentation and validation of the product in the natural environment, application of methodologies supporting the development of projects such as Lean Startup, Customer Development, Design Thinking). Start-ups will be subjected to an incubation programme of max. 4 m, with a wide range of basic services (including providing organizational support, work space, mentoring, accounting services, legal services, tax advice, basic marketing support and access to workshops in the field of public speeches, preparation of presentations for pitching sessions) and specialist (e.g. refinement of business models, verification of the idea, possibilities of financing, or development services).
Helical Axis Data Visualization and Analysis of the Knee Joint Articulation

We present processing methods and visualization techniques for accurately characterizing and interpreting kinematical data of flexion–extension motion of the knee joint based on helical axes. We make use of the Lie group of rigid body motions and particularly its Lie algebra for a natural representation of motion sequences. This allows to analyze and compute the finite helical axis (FHA) and instantaneous helical axis (IHA) in a unified way without redundant degrees of freedom or singularities. A polynomial fitting based on Legendre polynomials within the Lie algebra is applied to provide a smooth description of a given discrete knee motion sequence which is essential for obtaining stable instantaneous helical axes for further analysis. Moreover, this allows for an efficient overall similarity comparison across several motion sequences in order to differentiate among several cases. Our approach combines a specifically designed patient-specific three-dimensional visualization basing on the processed helical axes information and incorporating computed tomography (CT) scans for an intuitive interpretation of the axes and their geometrical relation with respect to the knee joint anatomy. In addition, in the context of the study of diseases affecting the musculoskeletal articulation, we propose to integrate the above tools into a multiscale framework for exploring related data sets distributed across multiple spatial scales. We demonstrate the utility of our methods, exemplarily processing a collection of motion sequences acquired from experimental data involving several surgery techniques. Our approach enables an accurate analysis, visualization and comparison of knee joint articulation, contributing to the evaluation and diagnosis in medical applications.
Evolutionary games between authors and their editors

This paper studies the evolution of manuscript quality control between authors and their editors, using evolutionary games.The frequency with which authors and their editors choose to submit/accept high-quality vs low-quality manuscripts change over time in response to the decisions made by all authors and editors in the respective populations.Using this dynamical structure, this paper shows which strategies become extinct and which survive, as well as whether the system approaches some stable end-point.We explore a number of case studies for editors' and authors' beliefs.Computer simulations are used to mimic a real world system of authors and their editors. Here we examine the evolution of manuscript quality control between authors and their editors, using evolutionary games. Within these games, with a certain probability, authors prefer to submit manuscripts of low- or high-quality, and editors prefer to accept low- or high-quality manuscripts. The frequency with which authors (editors) choose to submit (accept) high-quality or low-quality manuscripts change over time in response to the decisions made by all authors and editors in the respective populations. Using this dynamical structure, we study which strategies become extinct and which survive, as well as whether the system approaches some stable end-point. We also explore a number of case studies for editors' and authors' beliefs about that the submitted manuscripts must be of quality. When these beliefs are too weak, the stable end-point of the evolution is a situation in which the scientific communication system will be so broken that it should be abandoned. By contrary, when editors' beliefs are strong enough, scholarly communication will be reliable and will give the highest status to scientific research that is likely to be right and useful. In a third case study, when editors' beliefs are not strong enough, the growing gap between the need for quality manuscripts and the quality of the material submitted threatens scientific communication. Computer simulations are used to mimic a real world system of authors and their editors.
Arrayed waveguide grating type optical multiplexer/demultiplexer

An arrayed waveguide grating optical multiplexer/demultiplexer includes an arrayed waveguide connected to at least one first optical waveguide via a first slab waveguide, a plurality of second optical waveguides connected to the arrayed waveguide via a second slab waveguide. At least one expanding width waveguide has a first end portion and a second end portion having a second width larger than a first width of the first end portion. Each first end portion is connected to each first optical waveguide. The second end portion is connected to the first slab waveguide. The first width of the first end portion is larger than a first optical waveguide width of the at least one first optical waveguide. The first width of the first end portion satisfies a single mode condition. A width of the expanding width waveguide increases from the first end portion toward the second end portion.
Du bon usage de la contractualisation en droit de la propriété intellectuelle

The contractualization is a contemporary trend which crosses numerous branches of the law. As a process of regulation, it implies the participation of the stakeholders in the elaboration and the evolution of the law. This thesis aims at verifying its relevance and determining its impact in intellectual property law, domain dominated by the law and order, but subject to a deep loss of legitimacy. Reflecting a withdrawal of the law and order and a real dynamics of rule-making, the contractualization covers two levels. First of all, in the contractual relationship, the contractualization allows the holder of a subjective right to negotiate the exercise of its individual prerogatives and to confer a certain freedom and power to act that he can practice instead of his cocontracting party. In this case, the contractualization is presented as a vector of subjective rights. Then, in the upper level, the contractualization appears as a new mode of regulation. The stakeholders are associated to the elaboration of the law, either by delegation, or by incentive. This additional contractualization intends to produce private standards basing quite at the same time on the idea of flexibility and voluntary consent. These private standards will finally be received in the legal order assuming that they realize a balance between the economic utility of the proposed arrangement and the social value carried by compulsory rule. In this second prospect, the contractual standard appears as a legal model which should be encouraged, halfway between the spontaneous legal rule and the negotiated legal rule
Neurotechnologie zur Verbesserung der Lebensqualität und Prävention von Cybermobbing in 4.0

Das Hauptziel dieses Projekts ist die Unterstützung der Vorbereitung von Technologie und Wissenstransfer, Aktivitäten, die zur Kommerzialisierung von Forschungsergebnissen führen. Ziel des Projekts ist es, zwei Produkte zu entwickeln: 1) Technologie zur Verbesserung der Lebensqualität und 2) Verhinderung von Cybermobbing in 4.0. Im Zusammenhang mit der Anforderung der thematischen Ausrichtung der Aufforderung müssen die zu überprüfenden Produkte in einen der nationalen oder Prager Spezialisierungsbereiche fallen.
Life in arsenic rich environments: a challenge or an opportunity?

Arsenic is a notorious toxin, and as such may have exerted a strong selective pressure on the distribution and evolution of life on Earth. Despite evidence supporting the high levels and prominent role of As on the primitive Earth, the essentiality and toxicity of As, and its impact on evolutionary processes remains unexplored. AsLife aims at taking a novel approach to assessing microbial As cycling by exploiting two linked «environments». The first are the microbial mats from High-Altitude Andean Lakes, where it is known that As concentrations are far above background levels. Specifically, living and diagenetically-modified microbial mats will be investigated using scanning hard X-ray nanoprobes emerging at synchrotron facilities. This non-invasive and non-destructive technique provides data on a sub-micrometer scale by which to tie physiological inference from trace metal(loid)s distribution and speciation patterns directly to the microfossil biomass. Thus, providing a means to understand the interplay between microbial metabolisms and bio-availability of trace metal(loid)s in living and fossil ecosystems. The second environment comprises laboratory cultures, using the sampling power of «adaptive laboratory evolution» to explore how microbes adapt and enhance As detoxification facing the extreme As levels present in Andean Lakes. These results will be discussed in light of genomic studies of As-rich microbiota performed by Argentinian colleagues. 
During this project I will contact colleagues of the Jet Propulsion Laboratory in charge of the 2020 Mars Science Rover Mission and linked objective of returning samples for future analysis on Earth. I believe that my expertise in imaging and analyzing bio-geochemical proxies at multiple scales on a encapsulated geological sample can be relevant for contributing to the «Seek Signs of Life» Exploration Strategy of the 2020 Mission, thus establishing a strong and effective collaboration between EU and USA.
Drug repurposing and discovery multidisciplinary training network

Drug repurposing (or repositioning) is the application of previously identified drugs or compounds to treat new indications.
The International Rare Diseases Research Consortium (IRDiRC) set as main goal for 2027 that 1000 new therapies for rare
diseases will be approved. One of the levers to achieve this goal includes the repurposing of already existing and marketed
drugs. In this context, DRUGtrain offers a timely paradigm for multidisciplinary research ideal for improving drug repurposing
and development strategies of compounds, with Autosomal Dominant Polycystic Kidney Disease (ADPKD) as example.
Identifying compounds for repurposing requires a broad variety of approaches. Therefore, the aim of DRUGtrain is to offer a
multidisciplinary research training program to young researchers preparing them to become leading scientists able to
integrate molecular and pharmacological data, and translate fundamental research questions to the (pre)clinic and vice
versa.
The research objectives of DRUGtrain are: 1) To identify potential drug targets and drug candidates for repurposing using
innovative bio-informatics and cheminformatics approaches; 2) To perform drug testing/drug screenings in advanced in vitro
and in vivo models, ultimately leading to testing of new treatment strategies; 3) To clarify drug mechanisms, and identify and
reduce adverse events using state-of-the-art technologies from in silico and wet lab methodologies. Complementary training
through courses will cover additional topics in drug repurposing and drug discovery as well as scientific skills, personal
development, commerce and entrepreneurship.
In DRUGtrain, 6 academic and 4 private sector beneficiaries/partner organisations and 1 NGO are collaborating in joining
forces to intensify network activities between academia, industry, and a patient organization. The training offered should
support the ESRs in becoming the next generation of true multidisciplinary researchers in (bio)pharmaceutical sciences.
The Relationship between<i>Demodex</i>and Ocular Discomfort

To determine the correlative relationship between the prevalence of Demodex in eyelashes and the severity of ocular discomfort, by investigating the demographic epidemiology associated with Demodex.One hundred seventy patients underwent epilation of four eyelashes of each eye, and the number of Demodex was counted. The patients answered questionnaires about ocular surface discomfort and underwent ophthalmic examinations, including slit lamp, tear film breakup time (BUT), Schirmer test, and microbial culturing. The correlative relationship between the number of Demodex and these variable data was analyzed.Demodex was found in 120 (70%) of the 170 tested patients. Of 1360 eyelashes, 740 (54%) had Demodex. There was no significant difference in the prevalence of Demodex between males and females (P = 0.35). The number of Demodex showed significant positive correlations with increased age, ocular discomfort, and 1/BUT (P < 0.001), but not with the Schirmer scores. The number of Demodex was significantly higher in patients with conjunctival papillary hypertrophy than in those without (P = 0.003). The presence or distribution of bacteria on eyelashes was similar between eyelids with and without Demodex. However, methicillin-resistant Staphylococcus aureus (MRSA) was detected more often on eyelids with Demodex, but this difference was not statistically significant.There is a strong correlation between the number of Demodex and the severity of ocular discomfort, suggesting that Demodex plays a pathogenic role in the ocular discomfort linked with aging.
Information service method, information service unit, recording or reproducing controlling method, and recording and/or reproducing unit

Unique identification information is prerecorded on a disc. The identification information is registered to a server along with user's license when he or she buys the disc. When an terminal unit reproduces data from the disc, identification information is read and transmitted to the server through the Internet. The server creates a key that controls to reproduce data from the disc in accordance with the license identified by the identification information and transmits the key to the terminal unit along with the user's license information for the disc. The terminal unit controls to reproduce contents of the disc in accordance with key and license information transmitted from the server. The license for each disc is managed in accordance with the identification information. Thus, different services can be provided for individual discs.
Role of Ti3+ in CS2 conversion over TiO2 Claus catalyst

Abstract The objective of the study reported here was to unravel the reaction mechanism of TiO 2 catalysts used for CS 2 conversion in Claus process gas mixtures. Previously, it was demonstrated that the activity of titania exceeds that of alumina when used in the presence of H 2 S/SO 2 mixtures. In this study, it has been demonstrated that the presence and formation of Ti 3+ cation substantially improves CS 2 conversion activity for hydrolysis of CS 2 and for the Claus reaction process. This improvement is explained by a dual-centre adsorption model for CS 2 over titania which consists of chemisorption at adjacent Ti 3+ –Ti 4+ O groups. Understanding the role of Ti 3+ has allowed development of a more active Claus catalyst by introducing a pseudo “permanent Ti 3+ ” cation, Sc 3+ , into the framework structure of titania. Commercial implications based on above observation are also suggested for both catalyst designers and plant operation.
Circuit analysis of thalamic visual processing and its modulation by long-range projections

The thalamus, whose anatomical history goes back two millenia, has long been recognized as the master relay for sensory information propagating to cortex and consciousness. Yet, it is indisputable that thalamic nuclei are much more than simple relays but integrate different sensory modalities, bottom-up as well as top-down information. One elementary form of top-down modulation is attention, which selectively enhances behaviorally relevant information. Attentional modulation occurs already at the thalamus by, yet, unresolved circuit mechanisms. My research specifically aims at (1) exploring circuits for long-range, top-down modulation of thalamic visual processing, (2) dissecting the circuitry underlying attentional modulation, and (3) understanding basic rules of thalamic information processing. I will pursuit these three aims using an innovative combination of monosynaptic retrograde rabies tracing, optogenetics and deep 2-photon calcium imaging. My experiments will focus on the lateral geniculate nucleus (LGN), which is the main connection between the optic nerve and the visual cortex, as well as on the thalamic reticular nucleus (TRN), which provides major inhibitory input to LGN and has previously been implicated in attentional regulation. Notably, TRN deficits have been suggested to contribute to the clinical symptoms of schizophrenia. By rabies tracing, I will target channelrhodopsin to monosynaptic long-range inputs to the visual thalamus. By GRIN-lens assisted 2-photon imaging I will quantify visual responses and search for signatures of attentional modulation that can be induced by optogenetic stimulation of specific inputs. This approach will allow me to quantify attentional modulation of thalamic information-processing by specific long-range inputs, to dissect the underlying circuitry mechanisms and to contribute to a better understanding of thalamic computational power as well as its vulnerabilities.