SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Immunohistochemical assessment of ATG7, LC3, and p62 in ameloblastomas

Background

To investigate the roles of autophagy in tumorigenesis, cytodifferentiation, and prognosis of odontogenic tumors, we analyzed the immunohistochemical expression of ATG7, LC3, and p62 in odontogenic tissues.



Methods

Tissue specimens of nine dental follicles and 69 ameloblastomas were immunohistochemically examined with antibodies against ATG7, LC3, and p62.



Results

Immunohistochemical reactivity for ATG7, LC3, and p62 was detected in many odontogenic epithelial cells and several endothelial cells and fibroblasts in dental follicles and ameloblastomas. ATG7 reactivity in ameloblatomas was significantly higher than that in dental follicles. Expression of ATG7, LC3, and p62 was found markedly in neoplastic cells near the basement membrane rather than central polyhedral cells in ameloblastomas. Reactivity for these molecules was significantly higher in unicystic ameloblastomas than in solid ameloblastomas. Granular cells in granular cell ameloblastomas showed obvious reactivity for the autophagy- related molecules, and LC3 reactivity in granular cell ameloblastomas was significantly higher than in other ameloblastoma variations. Recurrent ameloblastomas showed significantly lower reactivity of LC3 and p62 than primary ameloblastomas.



Conclusions

Expression of ATG7, LC3, and p62 in dental follicles and ameloblastomas suggests that autophagy regulation might be affected by microenvironment alterations during tumorigenesis. The molecular machinery for autophagy is possibly involved in tissue architecture, neoplastic cell differentiation, and prognosis of the benign epithelial odontogenic tumor.
The general solution to HDR rendering

Our High-Dynamic-Range (HDR) world is the result of nonuniform illumination. We like to believe that 21st century
technology makes it possible to accurately reproduce any scene. On further study, we find that scene rendition remains a
best compromise. Despite all the remarkable accomplishments in digital imaging, we cannot capture and reproduce the
light in the world exactly. With still further study, we find that accurate reproduction is not necessary. We need an
interdisciplinary study of image making - painting, photography and image processing - to find the general solution.
HDR imaging would be very confusing, without two observations that resolve many paradoxes. First, optical veiling
glare, that depends on the scene content, severely limits the range of light on cameras' sensors, and on retinas. Second,
the neural spatial image processing in human vision counteracts glare with variable scene dependent responses. The
counter actions of these optical and neural processes shape the goals of HDR imaging. Successful HDR increases the
apparent contrast of details lost in the shadows and highlights of conventional images. They change the spatial
relationships by altering the local contrast of edges and gradients. The goal of HDR imaging is displaying calculated
appearance, rather than accurate light reproduction. By using this strategy we can develop universal algorithms that
process all images, LDR and HDR, achromatic and color, by mimicking human vision. The study of the general solution
for HDR imaging incorporates painting photography, vision research, color constancy and digital image processing.
A Hydroxyapatite-Collagen Composite Useful to Make Bioresorbable Scaffolds for Bone Reconstruction

Composites between hydroxyapatite (HA) and collagen (Col) may be used to make bioresorbable scaffolds for bone reconstruction. A suspension of micro-particles (average diameter ≅ 30 µm) of HA annealed at 1100°C in Col solution (80:20 HA to Col weight ratio) was manufactured in films by casting, and then some films were cross-linked by glutaraldehyde vapours. Cross-linked sponges were obtained by treating the suspension with transglutaminase, and by lyophilizing the so obtained gel. Characterization by scanning electron microscopy, water sorption test, Col release in water, thermogravimetric analysis and differential scanning calorimetry shows that the cross-linking enhances the stability of the composite. Conversely, neither the interactions between HA and Col, detected by spotlight FT-IR, nor the degradation by collagenase, which is a requirement for the bioresorbibility, are affected by the cross-linking.
"A METHOD AND APPARATUS FOR STIFFENING A FRAMEWORK MODULE FOR USE IN MODULAR BUILDING CONSTRUCTION"

A framework module (1) for use in modular building construction comprises a plurality of elongate upright and cross beams (2, 3) rigidly connected at or towards their ends to form a box frame with open side and end faces, and at least one elongate connection point (4) on one of the beams, configured to allow mutual connection with an equivalent connection point located on a substantially identical adjacent framework module so that a plurality of framework modules can be connected together to form an open-web truss of vertically and horizontally aligned members, the connection points (4) welded to the beams, the inner weld bead (102) between the inside edge of the connection point 4 and the surface of the beam concave and substantially uniform along the entirety of the weld bead (102).
Climate, landscape, settlement and society: exploring human-environment interaction in the ancient near east

Over the last 8000 years, the Fertile Crescent of the Near East has seen the emergence of cities, states and empires. Climate fluctuations are generally considered to be a significant factor in these changes because in pre-industrial societies they directly relate to food production and security. In the short term, ‘collapse’ events brought about by extreme weather changes such as droughts have been blamed for declines in population, social complexity and political systems. More broadly, the relationships between environment, settlement and surplus drive most models for the development of urbanism and hierarchical political systems. 

Studies seeking to correlate social and climatic changes in the past tend either to focus on highly localised analyses of specific sites and surveys or to take a more synthetic overview at much larger, even continental, scales. The CLaSS project will take a ground breaking hybrid approach using archaeological data science (or ‘big data’) to construct detailed, empirical datasets at unprecedented scales. Archaeological settlement data and archaeobotanical data (plant and tree remains) will be collated for the entire Fertile Crescent and combined with climate simulations derived from General Circulation Models using cutting edge techniques. The resulting datasets will represent the largest of their kind ever compiled, covering the period between 8000BP and 2000BP and an area of 600,000km2. 

Collecting data at this scale will enable us to compare population densities and distribution, subsistence practices and landscape management strategies to investigate the question: What factors have allowed for the differential persistence of societies in the face of changing climatic and environmental conditions? This ambitious project will provide insights into the sustainability and resilience of societies through both abrupt and longer term climate changes, leveraging the deep time perspective only available to archaeology.
Application of CFD Codes in Nuclear Reactor Safety Analysis

Computational Fluid Dynamics (CFD) is increasingly being used in nuclear reactor safety (NRS) analyses as a tool that enables safety relevant phenomena occurring in the reactor coolant system to be described in more detail. Numerical investigations on single phase coolant mixing in Pressurised Water Reactors (PWR) have been performed at the FZD for almost a decade. The work is aimed at describing the mixing phenomena relevant for both safety analysis, particularly in steam line break and boron dilution scenarios, and mixing phenomena of interest for economical operation and the structural integrity. For the experimental investigation of horizontal two phase flows, different non pressurized channels and the TOPFLOW Hot Leg model in a pressure chamber was build and simulated with ANSYS CFX. In a common project between the University of Applied Sciences Zittau/Görlitz and FZD the behaviour of insulation material released by a LOCA released into the containment and might compromise the long term emergency cooling systems is investigated. Moreover, the actual capability of CFD is shown to contribute to fuel rod bundle design with a good CHF performance.
A Comparative Study on the Complex-type High-rise Buildings Development Projects

The purpose of this study is to identify the planning characteristics of high-rise building development projects by comparing the selected 6 cases in terms of complex development background, master plan, and building plan. Each various development background influenced on the size and arrangement of uses, and caused differences of master plan, and consequently became an critical factor to decide the approaches to and design of high-rise buildings. New town development projects put an emphasis on the residential function with inner circulation, while urban renewal projects activated vertical connections on the basis of business functions to increase the efficiency of urban centers.
Galois representations and diophantine problems

Wiles' remarkable proof of Fermat's Last Theorem paved the way for the modular approach to Diophantine equations. This associates a Frey elliptic curve to a putative solution of a Diophantine equation and studies it using Galois representations and modularity. This proposal is organized around two research programmes, both of which develop new tools for the modular approach. The first is concerned with distinguishing Galois representations; this is currently the most frequent obstruction to the success of the approach. The second aims to prove modularity and irreducibility theorems for abelian varieties of GL2 type. Such theorems are of tremendous independent interest, but will also allow the replacement of Frey elliptic curves with Frey abelian varieties giving the modular approach immense flexibility.

The University of Warwick has a strong and active number theory group, making it a natural host for the project. The Supervisor, Professor Siksek, is a leading expert on curves, rational points, Diophantine equations and modularity, with considerable experience in supervising research including eight postdocs and ten completed PhD students.

The Researcher, Dr Freitas, did his undergraduate studies in Lisbon, and his PhD at the University of Barcelona. He has worked for almost three years in Germany (Bonn and Bayreuth), and is now a postdoctoral fellow at the University of British Columbia (Vancouver). He has a successful track record of research in modularity and Diophantine equations, with 12 papers already published or accepted in excellent journals. He was awarded the prestigious 2014 Jose Luis Rubio de Francia prize by the Spanish Mathematical Society. The envisioned research will make the Researcher influential in Diophantine equations and adjacent subjects. The project will reintegrate him into the European research environment, and allow him to realize his ambition of becoming an independent researcher at a leading European institution.
Advanced intra-operative navigation in arthroscopy surgery

Perceive3D (P3D) is an ICT driven company specialized in computer vision technology that creates advanced image software solutions for assisting and guiding the surgeon during minimally invasive procedures. In this project, P3D will specialize its state-of-the-art in.nav software technology for arthroscopic procedures of the knee and hip, providing the first effective solution for Computer-Assisted Orthopedic Surgery (CAOS) in arthroscopy. The outcomes of the project will be two software applications (nav4ACL and nav4FAI) that will provide real-time intra-operative measurements to aid the surgeons throughout the procedures by providing measurements of the joint structure. Guiding information is provided in accordance to the literature to support the surgeon’s decision, leading to a system that will improve clinical outcome for patients and reduce healthcare costs. As part of the Horizon 2020 SMEInst-01 phase I project, P3D performed a feasibility study for the development of in.nav navigation software for two arthroscopic procedures: the Antero Cruciate Ligament (ACL) reconstruction in knee arthroscopy, and the removal of Femoroacetabular Impingement (FAI) in hip arthroscopy. A pressing need for assistive systems has been reported for the procedures for these frequent pathologies. This phase II project will leverage these results and translate the in.nav prototype into two commercially viable software products for ACL and FAI procedures. P3D will demonstrate the use and advantages of the in.nav navigation software through tests in post-mortem subjects and will prepare the applications for integration into existing surgical workflows and market deployment. P3D has already approached Key Opinion Leaders (KOL) in the targeted procedures (Knee and Hip) to endorse the in.nav technology and P3D will extend its IP portfolio around this in.nav navigation technology.
Extraction, characterization and spontaneous emulsifying properties of pectin from sugar beet pulp

The effects of organic acid extractants on the yield and characteristics of pectin from sugar beet pulp were investigated with citric acid, malic acid and lactic acid at different pH (1.5 and 2.0) and time (1 h and 2 h). The results demonstrated that the yields of pectins were directly correlated with the decrease of pH and reaction time, and the optimum yield of 17.2% was obtained at pH 1.5 and 2 h. Furthermore, the acid type also affected the physicochemical characteristics of pectin, especially on the esterification degree (42-71), galacturonic acid content (60.2-77.8%), emulsion activity (35.2-40.1%) and emulsion stability (62.1-79.4%), and a relatively single pectin mainly consisted of homogalacturonan could be obtained under a suitable reaction condition, which was an excellent crude material for the production of emulsion activity.
[CEBPA gene mutation analysis in acute myeloid leukemia].

To investigate the incidence, molecular features and clinical significance of CCAAT/enhancer binding protein alpha (CEBPA) gene mutation in patients with acute myeloid leukemia (AML).Mutation analysis of the entire coding region of CEBPA gene in 206 de novo AML patients was performed by using polymerase chain reaction (PCR) followed by sequence analysis and fragment length analysis.Of 206 AML patients, 31 (15%) had CEBPA gene mutations, including 23 with double mutations (duCEBPA) and 8 with single mutation (siCEBPA). CEBPA gene mutations presented mainly in M2 subtype or intermediate risk patients. As compared with those with wild type CEBPA gene, patients with mutated CEBPA gene were of higher white blood cell counts [20.92(0.86-351.43)× 10(9)//L vs 8.17(0.47-295.2) × 10(9)/L, P=0.003], higher hemoglobin levels [97.5(51-128) g/L vs 80.5(13-153) g/L, P=0.015] and lower platelet counts [27.5(5-81)× 10(9)//L vs 44(3-548)× 10(9)/L, P=0.004]. Patients with CEBPA gene mutation had higher complete remission (CR) rate than those with wild type (P=0.009). While co-existing of NPM1 and siCEBPA mutations was observed in M5 subtype (2/8, 25%), NPM1 gene mutation was not present in any patients with duCEBPA mutation (0/23, 0%). Dynamic tracking analysis showed that CEBPA mutations disappeared at CR, and the same mutations re-appeared at relapse. When compared to sequence analysis, the coincidence rate of CEBPA mutations detected by fragment length analysis was 100% (54/54).CEBPA gene mutation is a recurring genetic change in AML patients and has a certain correlation with clinical and laboratory features. It could be reliably used as a potential marker for minimal residual disease follow up. The prognostic significance of co-existing of siCEBPA with NPM1 mutations in patients with AML-M5 subtype needs further investigation.
Walser Alps - modernity and tradition in the heart of Europe
The Walser settlements area -  a laboratory to experience a post-industrial sustainable Alpine society in a bottom-up process

The minority of Walser settle dispersed over six countries in the heart of Europe. Most of them suffer under economic disadvantage, but have conserved traditional rural knowledge.
The Walser Alps project aims to experience - as a pilot action based on the Agenda 21 process - the transfer from a pre-industrial to a sustainable competitive post-industrial society integrating youth.
Landscape is the link between, on one hand, spatial development and, on the other hand, culture. Culture is a key feature for minorities to define and defend their characteristics, specificities and sustainability (Agenda 21). Landscape is a concrete, appropriate medium to integrate youth.
The method consists of confronting images to let the Walser population face the "mirror" of their own social features. Matching interior and exterior images can raise consciousness to forecast future developments.
Those experiences will serve for a spatial planning tool and for an exchange of best practice with other minorities.
Electrochemical DNA Hybridization Sensor Using Poly[vinylpyridine Os(bipyridine)2Cl]-co-Ethylamine Redox Polymer

DNA hybridization sensors are important for diseases diagnosis. Until now, many approaches have been proposed for the DNA hybridization examination. These include fluorescence based, electrochemical and colorimetric based. Electrochemical hybridization for detection of DNA sequences requires the development of easy to-use, fast, inexpensive, miniaturized analytical devices. In this work, a simple electrochemical DNA hybridization sensor that uses poly[vinylpyridine Os(bipyridine)2Cl]-co-ethylamine redox polymer as the indicator was assembled. The electrochemical behavior of poly[vinylpyridine Os(bipyridine)2Cl]-co-ethylamine redox polymer polymer with both single stranded DNA (ssDNA-SH) probe and double stranded DNA (dsDNA) was determined. Both cyclic voltammetry and impedance spectroscopy results indicated strong binding of the new redox polymer onto DNA. A hybridization process involving a monolayer of a 24-mer thiol-tethered DNA capture probe on gold electrode and the corresponding complementary strand were clearly demonstrated. DNA double strand after disruption with free radicals could also be detected. The biosensor system has potential for use to recognize of damaged DNA sequences.     Keywords: Cyclic voltammetry; Hybridization; Poly[vinylpyridine Os(bipyridine) 2 Cl]-co-ethylamine.
Acute effects of deep breathing for a short duration (2-10 minutes) on pulmonary functions in healthy young volunteers.

Breathing is the most vital function for maintenance of life. Slow and deep breathing is an integral part of Pranayama and it reduces dead space ventilation and renews air throughout the lungs. The reported beneficial effects of deep breathing as a part of either long term or short term practice of Pranayama are well documented. However our knowledge about the effects of a few minutes' of deep breathing on human ventilatory parameters is poor. In the present study, we examined the relationship between exposure to short duration of deep breathing and performance on pulmonary function tests before and after the deep breathing. The study was conducted in a homogenous group of 12 volunteers containing 4 females and 8 males who were well trained in pulmonary function testing (PFT) before the start of the study. The volunteers performed deep breathing (DB) exercise for 2, 5 and 10 minutes at the rate of 6 breaths per minute under guidance, and the duration of DB exercise for that day was randomly selected for each group. PFT was done before and after the DB exercise. There was a significant (P < 0.05) increase in vital capacity (VC) after 2 and 5 minutes' DB exercise and a consistent improvement in tidal volume (TV) and minute ventilation (MV) after the DB exercise in all the three groups, though it wasn't statistically significant. There was a significant (P < 0.05) increase in forced vital capacity (FVC) after 2 minutes' of DB exercise and a consistent increase in all the three groups in forced inspiratory vital capacity (FIVC) and peak inspiratory flow rate (PIFR), though this increase was not statistically significant. This shows that deep breathing exercise, even for a few minutes' duration is beneficial for the lung functions.
ELECTRIC MOTOR AND METHOD FOR MANUFACTURING SAID MOTOR

The present invention relates to an electric motor comprising a stator assembly and a rotor assembly rotatable about a rotor axis. The rotor assembly includes a rotor core having a laminated structure defined by a plurality of sheets made of magnetic material, and a plurality of seats configured to receive respective permanent magnets. The rotor assembly further includes at least an end plate arranged so as to cover an end surface of the rotor core and the plurality of seats in the axial direction. In particular, the end plate is made of magnetic material and it comprises a plurality of flux barrier slits configured so as to be prevalently transversal to the portions of the magnetic flux lines to which they are superimposed when seen along the axial direction.
Faciliter l’entrée d’OPTAGLIO s.r.o. sur les marchés étrangers

Le projet vise à faciliter l’entrée d’OPTAGLIO s.r.o. sur de nouveaux marchés étrangers par la participation à des expositions et foires étrangères spécifiques dans le domaine de la protection des documents d’État. OPTAGLIO s.r.o. opère dans le domaine des technologies axées sur les éléments optiques de sécurité et les hologrammes et prévoit de pénétrer de nouveaux marchés à travers des foires commerciales internationales.
The world through Arab eyes: Arab public opinion and the reshaping of the Middle East

Once a voiceless region dominated by authoritarian rulers, the Arab world seems to have developed an identity of its own almost overnight. The series of uprisings that began in 2010 profoundly altered politics in the region, forcing many experts to drastically revise their understandings of the Arab people. Yet while the Arab uprisings have indeed triggered seismic changes, Arab public opinion has been a perennial but long ignored force influencing events in the Middle East. In The World Through Arab Eyes, eminent political scientist Shibley Telhami draws upon a decade's worth of original polling data, probing the depths of the Arab psyche to analyze the driving forces and emotions of the Arab uprisings and the next phase of Arab politics. With great insight into the people and countries he has surveyed, Telhami provides a longitudinal account of Arab identity, revealing how Arabs' present-day priorities and grievances have been gestating for decades. The demand for dignity foremost in the chants of millions went far beyond a straightforward struggle for food and individual rights. The Arabs' cries were not simply a response to corrupt leaders, but were in fact inseparable from the collective respect they crave from the outside world. Decades of perceived humiliations at the hands of the West have left many Arabs with a wounded sense of national pride, but also a desire for political systems with elements of Western democracies--an apparent contradiction that is only one of many complicating our understanding of the monumental shifts in Arab politics and society. In astonishing detail and with great humanity, Telhami identifies the key prisms through which Arabs view issues central to their everyday lives, from democracy to religion to foreign relations with Iran, Israel, the United States, and other world powers. The World Through Arab Eyes reveals the hearts and minds of a people often misunderstood but ever more central to our globalized world.