SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Pharmacovigilance on twitter? Mining tweets for adverse drug reactions.

Recent research has shown that Twitter data analytics can have broad implications on public health research. However, its value for pharmacovigilance has been scantly studied - with health related forums and community support groups preferred for the task. We present a systematic study of tweets collected for 74 drugs to assess their value as sources of potential signals for adverse drug reactions (ADRs). We created an annotated corpus of 10,822 tweets. Each tweet was annotated for the presence or absence of ADR mentions, with the span and Unified Medical Language System (UMLS) concept ID noted for each ADR present. Using Cohen's kappa1, we calculated the inter-annotator agreement (IAA) for the binary annotations to be 0.69. To demonstrate the utility of the corpus, we attempted a lexicon-based approach for concept extraction, with promising success (54.1% precision, 62.1% recall, and 57.8% F-measure). A subset of the corpus is freely available at: http://diego.asu.edu/downloads.
Open network of hyper connected logistics clusters towards physical internet

“If we want to reach the EU objective on modal shift for all transportation beyond 300 km and attract and strengthen competitiveness of local industries at the same time, we need to drive the development of a network of hyper connected logistics multimodal clusters and their influence areas”. Clusters 2.0 Consortium
Clusters 2.0. vision is to leverage the full potential of European Logistics Clusters for an efficient and fully integrated transport system in Europe making optimal use of an Open Network of Logistics Clusters and hubs starting with. Zaragoza (PLAZA), Duisburg (Duisport), Lille (Dourges), Bologna-Trieste (Interporto/port of Trieste), Brussels (BruCargo), London (Heathrow), Pireaus (PCT), Trelleborg (Port), while keeping neutral the environmental and local impacts such as congestion, noise, land use and local pollution levels.
Cluster 2.0 objectives and areas of intervention are:
Increase the engagement, performance and coordination of terminals and hubs at cluster level targeting: i) increase by 50% the freight managed in the cluster whit current infrastructure, ii) Double the value added activities and iii) increase economic impact in local economies by 5% yearly while keeping neutral local environmental impacts. Build a hyper connected network of logistics hubs and clusters targeting: i) increase average door-to-door vehicle load factor up to 75%, ii) increase intermodal transport in the network by 40%. Develop low cost, low capital and investment intensive transhipment enhanced solutions to reduce operational costs of transhipment by 30 %. Develop prototypes of New Modular Load Units as enhancers of the above objectives.Develop terminal management systems to increase management capacity of the terminals by 20% and reduce associated congestion by 10%. Establish and run 5 Living Labs (LLs) to test, improve an validate proposed solutions as well as to and Develop Business Models and Robust Business Plans for Clusters 2.0 solutions.
UNIVERSAL ECG ELECTRODE MODULE FOR SMARTPHONE

Apparatuses and methods for sensing an electrocardiogram (ECG) of a subject using an ECG module that may removably connect to a mobile telecommunications device through a base unit, and which may further then wirelessly communicate with the mobile telecommunications device.
Can non-viral technologies knockdown the barriers to siRNA delivery and achieve the next generation of cancer therapeutics?

Cancer is one of the most wide-spread diseases of modern times, with an estimated increase in the number of patients diagnosed worldwide, from 11.3 million in 2007 to 15.5 million in 2030 (www.who.int). In many cases, due to the delay in diagnosis and high increase of relapse, survival rates are low. Current therapies, including surgery, radiation and chemotherapy, have made significant progress, but they have many limitations and are far from ideal. Although immunotherapy has recently offered great promise as a new approach in cancer treatment, it is still very much in its infancy and more information on this approach is required before it can be widely applied. For these reasons effective, safe and patient-acceptable cancer therapy is still largely an unmet clinical need. Recent knowledge of the genetic basis of the disease opens up the potential for cancer gene therapeutics based on siRNA. However, the future of such gene-based therapeutics is dependent on achieving successful delivery. Extensive research is ongoing regarding the design and assessment of non-viral delivery technologies for siRNA to treat a wide range of cancers. Preliminary results on the first human Phase I trial for solid tumours, using a targeted non-viral vector, illustrate the enormous therapeutic benefits once the issue of delivery is resolved. In this review the genes regulating cancer will be discussed and potential therapeutic targets will be identified. The physiological and biochemical changes caused by tumours, and the potential to exploit this knowledge to produce bio-responsive 'smart' delivery systems, will be evaluated. This review will also provide a critical and comprehensive overview of the different non-viral formulation strategies under investigation for siRNA delivery, with particular emphasis on those designed to exploit the physiological environment of the disease site. In addition, a section of the review will be dedicated to pre-clinical animal models used to evaluate the stability, safety and efficacy of the delivery systems.
Quantitative Analysis of Drug- Drug Interactions of OTC Drugs with other Prescribed Drugs Collected from Different Hospitals and Clinics of Karachi, Pakistan.

In the modern era of health profession, drug prescribing practices have become more complicated as the number of drug inventions is increasing with numerous diseases which lead to a situation to prescribe a concurrent therapy of more than one therapeutic regime at a time. Under these clinical circumstances, in spite of making a patient profile and close monitoring of medication dosage, there is an increased incidence tendency of drug interaction which may counteract the mechanism of each other. The core aim of the current study is to analyze the drug-drug interactions of OTC drugs with other prescribed drugs. For this purpose, a total number of 448 prescriptions were collected from different retail pharmacies and physician clinics running under the hospitals of Karachi, Pakistan over a period of 9 months (Jan, 2009 to Sep, 2009). Software Micromedex (R) Healthcare Series, Vol.142, 1974 – 2009, Thomson Reuter, was used as a reference to determine the interactions. The total numbers of 2124 of drug-drug combinations were reviewed under the study, out of which 357 drug-drug interactions were identified in the entire study. On the basis of Micromedex software drug-drug interaction categorization, these 357 drug-drug interactions were categorized into the Severity, Onset and Documentation. Based on Severity, 13 (3.46%) interactions were found to be Major, 275 (77.03%) were Moderate and 69 (19.33%) were Minor. Based on Onset, 115 (32%) interactions were reported as Rapid and 236 (66%) were Delayed, and 6 (2%) were not specified. Based on Documentation, 11 (3%) interactions were documented as an Excellent, 224 (63%) interactions were Good and 122 (34%) interactions were Fair. Overall, the end results of the entire study found interactions of Aspirin with ACE inhibitors and Clopidogrel, Iron, Zinc and Calcium with Ciprofloxacin, while Ibuprofen with Lisinopril as a top large number of interactions. However, the current study raises the awareness of the pharmacist to make an intervention strategy on emphasizing the proper prescribing practice and to take a holistic approach toward the further enrichment of opportunities subsist for greater involvement in safe and effective utilization of therapeutic regime.
Design of CEPC superconducting RF system

CEPC is a 100-km double-ring circular electron–positron collider operating at 90–240 GeV center-of-mass energy of Z-pole, WW-pair production threshold and Higgs resonance. The conceptual design report (CDR) of CEPC has been published as an important step to move the project forward. The superconducting RF (SRF) system is one of the most important and challenging accelerator systems due to the wide range of beam energy and current. In this paper, the layout, parameters and configuration of the superconducting RF system for the CEPC collider ring will be introduced. Issues of beam cavity interactions including transient beam loading and coupled-bunch instabilities of accelerating mode are discussed.
Upscaling and commercialization of a highly efficient wood pellets fired steam engine chp for heat and power generation

Upscaling and commercialization of a highly efficient wood pellets fired steam engine CHP for heat and power generation.
The aim of this project is the upscaling and commercialization of a developed CHP (combined heat and power generating
system) comprising a highly efficient wood pellets fired steam engine. The CHP power output is 50kW electrical and 175kW
thermal power with 20% electrical and 90% overall efficiency based on wood pellets . We achieve these test bench proven
parameters by developing a steam engine technology with a new approach. The technology readiness level is TRL7. This
CHP technology has a potential energy costs saving rate of up to 84% for customers compared to natural gas heating and grid power. This high efficiency is achieved by applying steam inlet conditions in excess of 500°C and 100bar. This technology is developed with the focus on costs, reliability, efficiency and mass production. The basic patent process will be finished in 2014. By applying this technology throughout the EU, the carbon dioxide production could be lowered significantly as the fuel for this technology is wood or any other solid biomass or organic waste, which is burned highly efficient within the process. As this technology has base load capability, this would be a perfect supplement for the existing renewable energy systems like photovoltaics and wind.
Also, the dependency on fossil energy like oil and gas could be lowered. As the used fuel grows everywhere in the EU, the
price of energy produced by this technology will be lower. Moreover the price will be much more time stable as there are
thousands of wood suppliers who make this market much more competitive than the existing fossil fuel market with the
monopoly of only a few suppliers.
The aim of of the feasibility study is to investigate the market positioning and commercialization strategy of the proposed
upscaled CHP in terms of size, pricing and market launch strategy followed by the SME Phase 2 project.
Can cannabis use be prevented by targeting personality risk in schools? Twenty‐four‐month outcome of the adventure trial on cannabis use: a cluster‐randomized controlled trial

Aims

To examine the effectiveness of a personality-targeted intervention program (Adventure trial) delivered by trained teachers to high-risk (HR) high-school students on reducing marijuana use and frequency of use.



Design

A cluster-randomized controlled trial.



Setting

Secondary schools in London, UK.



Participants

Twenty-one secondary schools were randomized to intervention (n = 12) or control (n = 9) conditions, encompassing a total of 1038 HR students in the ninth grade [mean (standard deviation) age = 13.7 (0.33) years].



Interventions

Brief personality-targeted interventions to students with one of four HR profiles: anxiety sensitivity, hopelessness, impulsivity and sensation-seeking.



Measurements

Primary outcome: marijuana use. Secondary outcome: frequency of use. Assessed using the Reckless Behaviour Questionnaire at intervals of 6 months for 2 years. Personality risk was measured with the Substance Use Risk Profile Scale.



Findings

Logistic regression analysis revealed significant intervention effects on cannabis use rates at the 6-month follow-up in the intent-to-treat sample [odds ratio (OR) = 0.67, P = 0.05, 95% confidence interval (CI) = 0.45–1.0] and significant reductions in frequency of use at 12- and 18-month follow-up (β = –0.14, P ≤ 0.05, 95% CI = –0.6 to –0.01; β = –0.12, P ≤ 0.05, 95% CI = –0.54 to 0.0), but this was not supported in two-part latent growth models. Subgroup analyses (both logistic and two-part models) reveal that the sensation-seeking intervention delayed the onset of cannabis use among sensation seekers (OR = 0.25, β = –0.833, standard error = 0.342, P = 0.015).



Conclusions

Personality-targeted interventions can be delivered effectively by trained school staff to delay marijuana use onset among a subset of high-risk teenagers: sensation-seekers.
Building the blue biotechnology community in the Mediterranean

10 partners with proved experience in the Blue Bioeconomy field from 8 Med countries and more than 300 Med stakeholders from universities, research centers, public authorities, business support organizations & Med multilateral organizations, working together for 22 months to create the Blue Biotechnologies (BBt) community in the Mediterranean. The exploitation of marine bio-resources through biotechnological solutions is a field with massive potential for innovation & economic growth, but it is a relatively young discipline, so opportunities & key enabling factors need a coordination.B-Blue project aims at gathering the key actors of the Med BBt sector and increase their innovation capacity and their coordination in order to unlock the innovation potential in the field through joint transnational initiatives, involving also organizations from the Southern Shore of the Mediterranean. The transnational coordination framework, the project aims to create, is based on an inclusive quintuple-helix approach always including the socio-environmental perspective in the decisional process and building on a common knowledge ground selected on the basis of its potential of addressing the SGDs at Med level. The B-Blue work towards to the implementation of a transnational coordination mechanism for the BBt community through the mutual interconnection the digital BBt community platform & a Med network of territorial based-collaborative space on selected BBt value chains (BBt HUBs).
A Study on the Automatic Sensing Device for Gas Leakage of Cooling Plate Using the Microprocessor System

The cooling water circulation plates had been used to drop the temperature of refractory outside shell of common cooling system by using cooling plate or stave type. When they are attacked by surrounding gas, they are corroded and the water flows in the refractory due to leakage of water. So, the life of refractory material is shortened and changed due to the worse conditions of cooling system. The automatic sensing device for water leakage of cooling plate is developed to check the position of trouble by using the microprocessor system when cooling water leak and gas are flowed into the cooling plate through the leakage position. The flowed gas is detected in the micro-process system which delivers the detected position of cooling plate or stave to main control room through the wireless-radio relay station. This system can be possible to detect the position of cooling plate or stave against the water leakage part immediately and then deliver the signal to main control room by using the microprocessor system and wireless-radio relay station. This system will be developed in changing the working condition from manual system to unmanned auto alarm system.
Unified Service Management

The described unified service management system provides a unified console to perform functions of individual management specialists. A unified console facilitates an administrator to perform the complex tasks that were performed by the individual management specialists. The unified console provides a "wizard" based approach to the administrator to design all aspects of the complex tasks including placement of components or computing devices, deciding on policies of the components or computing devices, deciding on health policies of components or computing devices, fixing data protection policies of components or computing devices, etc.
Beyond Spreadsheets with R: A beginner's guide to R and RStudio

Data Munging with R shows readers how to take raw data and transform it for use in computations, tables, graphs, and more. Whether they already have some programming experience or they're just a spreadsheet whiz looking for a more powerful data manipulation tool, this book will help programmers get started. Readers will discover the ins and outs of using the data-oriented R programming language and its many task-specific packages. By the end, readers will be master mungers, with a robust, reproducible workflow and the skills to use data to strengthen their conclusions! Key Features * Practical examples * Step-by-step guide * Introduction to R Audience If you have beginner programming skills or you're comfortable with writing spreadsheet formulas, you have everything you need to get the most out of this book. About the technology R is a statistical programming language in that it was made for the purpose of performing statistics calculations, but it has grown to be so much more through community contributions. As a general purpose language, it is flexible enough to work with almost any data you can interact with; stored or streaming, images, text, or numbers.
Flexible CO2 laser fiber: first look at the learning curve required in gynecological laparoscopy training

The advent of flexible CO2 laser fiber to gynecology arena might represent a turning point in the use of laser energy on a large-scale basis in gynecological surgery. However, there might be some concerns regarding the degree of surgical skills required to use the flexible system. The purpose of our study is to evaluate whether flexible CO2 laser fiber is technically accessible.Fourteen residents in Obstetrics and Gynecology without surgical experience attending laparoscopic box training with both flexible CO2 laser fiber and traditional line-of-sight CO2 laser using Lumenis AcuPulse Duo CO2 laser (Lumenis, Yokne'am Illit, Israel) were prospectively enrolled. Participants were tested at sequential time points on specific surgical tasks and results obtained with the flexible CO2 laser fiber and the traditional line-of-sight CO2 laser were compared. Results were compared by means of paired t-test and a two-tailed P value <0.05 was considered significant.Mean grading at the beginning of training were similar between flexible fiber and line-of-sight CO2 laser. At the end of training, significant improvement in surgical skills was obtained for both techniques, with a statistically significant higher grading for flexible fiber CO2 laser compared to line-of-sight CO2 laser.Our study found that residents without surgical experience show better skills with the flexible CO2 laser fiber delivery system compared to the standard line-of-sight CO2 laser system after a two-month training period with gynecological laparoscopic box. According to our results, flexible CO2 laser fiber delivery system is technically accessible and holds a potential in gynecological surgery.
Additional file 1 of Factors associated with anaemia among preschool- age children in underprivileged neighbourhoods in Antananarivo, Madagascar

Additional file 1.
Alternative splicing networks in pancreatic beta cells

Type 1 diabetes (T1D) is a chronic autoimmune disease in which pancreatic beta cells are killed by infiltrating immune cells and by cytokines released by these cells. The mechanisms by which autoimmunity is triggered and aggravated in T1D and the nature of the intracellular signals that decide beta cell fate between survival or death remain to be clarified. Alternative splicing (AS) is a complex mechanism of gene expression regulation and a potent generator of proteome diversity. It provides cells with an exquisite capacity to rapidly modify their transcriptome and proteome in response to intra and extracellular cues. AS affects more than 90% of human genes and has a major impact in many cellular processes, including cell survival and generation of new antigenic epitopes. There is a growing interest in the role of AS in autoimmune diseases but nearly nothing is known on its role in beta cells and diabetes. Recent findings by the host group indicate that pro-inflammatory cytokines change the expression of >30 RNA-binding proteins (RBPs) and modify AS of >3000 genes in human beta cells. Importantly, the host group has discovered that the diabetes candidate gene GLIS3 affects beta cell apoptosis by regulating the splicing of the pro-apoptotic BH3-only protein Bim. These findings suggest that AS plays an important role in the regulation of beta cell dysfunction and death by mechanisms that remain to be clarified. We hypothesise that pro-inflammatory signals activate splicing networks contributing to beta cell functional lost and death. We propose in the present project a systems biology approach that will combine RNA-seq, network inference and analysis of individual RBPs to characterize and validate inflammation-activated splicing networks in beta cells. The ultimate goal is to identify key splicing networks and mRNA splice variants that will be targeted by splicing-modulation molecules as a novel therapeutic strategy to prevent progressive beta cell loss in T1D.
Method of Tracking Health and Performance Statistics of Visitors to a Health Theme Park

A method of tracking health and performance statistics of visitors to a health theme park is utilized to monitor vital signs and activity performance (VSAP) statistics for visitors participating in a theme park activity. At least one database server manages a plurality of user profiles for visitors to the theme park. The VSAP statistics are measured during the theme park activity with a corresponding wearable health monitoring (WHM) device that is associated with the visitor. The visitor is ranked amongst other visitors based on at least one performance metric that is quantitatively assessed based on the VSAP statistics. A performance rank is generated based on the at least one performance metric. The corresponding WHM device is capable of a plurality of ancillary features that may be selected through the corresponding WHM device. A desired feature is executed with the at least one database server.
On the Molecular and Electronic Structures of AsP3 and P4

The molecular and electronic structures of AsP(3) and P(4) have been investigated. Gas-phase electron diffraction studies of AsP(3) have provided r(g) bond lengths of 2.3041(12) and 2.1949(28) A for the As-P interatomic distances and the P-P interatomic distances, respectively. The gas-phase electron diffraction structure of P(4) has been redetermined and provides an updated value of 2.1994(3) A for the P-P interatomic distances, reconciling conflicting literature values. Gas-phase photoelectron spectroscopy provides experimental values for the energies of ionizations from the valence molecular orbitals of AsP(3) and P(4) and shows that electronically AsP(3) and P(4) are quite similar. Solid-state (75)As and (31)P NMR spectroscopy demonstrate the plastic nature of AsP(3) and P(4) as solids, and an extreme upfield (75)As chemical shift has been confirmed for the As atom in AsP(3). Finally, quantum chemical gauge-including magnetically induced current calculations show that AsP(3) and P(4) can accurately be described as strongly aromatic. Together these data provide a cohesive description of the molecular and electronic properties of these two tetraatomic molecules.