SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Insurability challenges under uncertainty: An attempt to use the artificial neural network for the prediction of losses from natural disasters

The main difficulty for natural disaster insurance derives from the uncertainty of an event's damages. Insurers cannot precisely appreciate the weight of natural hazards because of risk dependences. Insurability under uncertainty first requires an accurate assessment of entire damages. Insured and insurers both win when premiums calculate risk properly. In such cases, coverage will be available and affordable. Using the artificial neural network - a technique rooted in artificial intelligence - insurers can predict annual natural disaster losses. There are many types of artificial neural network models. In this paper we use the multilayer perceptron neural network, the most accommodated to the prediction task. In fact, if we provide the natural disaster explanatory variables to the developed neural network, it calculates perfectly the potential annual losses for the studied country.
THE PANTHER FRONT AND REAR WHEEL DRIVE BICYCLE

The regular handlebar and front wheel of a bicycle are replaced by a steering head including a pair of hand cranks, and by a sprockets-containing front wheel. The hand cranks are positioned such that the rider s weight center is stabilized unto the cycle s seat, away from his hands. A sprocket mounted unto the hand cranks drive shaft transmits the power from the hand cranks, through a continuous chain, to the front wheel s sprockets. A set of brake cables and bearings prevent the brakes cables from twisting, while rotating the hand cranks. The cycle s seat is provided with a back support. The rider can position the hand cranks in unison or alternatively. The rider can drive the bicycle by simultaneous or independent foot and hand operation. The addition of a set of hand cranks to a regular bicycle enables an increase in the cycle s speed, along with intensified exercise. The hand cranks system can be mounted and unmounted onto any existing bicycle. The hand cranks mechanism exhibits great simplicity, while maintaining safety and very good steering ease.
SYSTEM AND METHOD FOR DELIVERING MODULAR TOOLS

A system and method are presented for delivering modular tools through a cloud-based remote computing environment. Users may create and customize extensions to the modular tools for integration with the product system without requiring change to product. Using a script tag added to a website, a user is able to install the modular tool to a website. The modular tool extensions are able to directly communicate with handlers and websites and are able to become directly integrated with a premises-based product. This may be done through a multiplexed API exposed to the modular tool extensions that directly couples them to the premises-based product. The modular tools are able to be configured in the premises-based product, however they are hosted in the cloud and as such, the premises-based product is able to receive continuous integration and deployment from the cloud.
Microilcs: deciphering how the gut microbiota influences innate lymphoid cells in obesity""

Obesity reaches epidemic proportions and currently represents a significant public health challenge. Curbing the prevalence of obesity is one health policy priority, whose achievement requires more effective preventive measures. A high-caloric diet and sedentary lifestyle are key determinants of obesity. The diet shapes gut microbiota composition, which may partly explain why microbiota alterations are associated with an obese phenotype in humans. These microbial alternations have been proven to contribute to energy metabolism and fat storage. This evidence has represented an unprecedented shift in the way we envision obesity management. However, translating this knowledge into microbiota modulation strategies that can be applied in the clinical setting needs a better understanding of the active players within the gut ecosystem, as well as, of the mechanisms underlying their dialog with the host. Preclinical studies show that the microbiota shapes immune responses beyond the intestine with consequences for metabolic health. This proposal aims to decipher the regulatory role of indigenous intestinal bacteria on the recently discovered innate lymphoid cells (ILCs). To achieve this goal, we will use the collection of intestinal human bacteria created in the context of the EUproject MyNewGut by the host institution, first, to identify those with ILCs stimulatory properties and second, to perform mechanistic studies in wild-type and mutant murine models of diet-induced obesity coupled to in vitro experiments with primary cell cultures. Overall, the objective of the MicroILCs proposal is to move forward in the understanding of the mechanisms whereby the gut microbiota controls the immune response to high-energy diets and affects the metabolic phenotype.
Probing the Symmetries of the Dirac Hamiltonian with Axially Deformed Scalar and Vector Potentials by Similarity Renormalization Group

Symmetry is an important and basic topic in physics. The similarity renormalization group theory provides a novel view to study the symmetries hidden in the Dirac Hamiltonian, especially for the deformed system. Based on the similarity renormalization group theory, the contributions from the nonrelativistic term, the spin-orbit term, the dynamical term, the relativistic modification of kinetic energy, and the Darwin term are self-consistently extracted from a general Dirac Hamiltonian and, hence, we get an accurate description for their dependence on the deformation. Taking an axially deformed nucleus as an example, we find that the self-consistent description of the nonrelativistic term, spin-orbit term, and dynamical term is crucial for understanding the relativistic symmetries and their breaking in a deformed nuclear system.
Regional Industrial Structure Adjustment and Competitiveness Research——Based on the Shift-share Method in Dongying City

As a typical oil city,the adjustment,optimization and upgrading in industry structure is the key to the sustainable development in Dongying City.By using the shift-share method,based on the development tendency of Dongying industrial structure,according to the Shandong province from the geographical factors,the structure factors and the competitive factors three perspectives,the development status of industry economy was analyzed from 2003 to 2008.The results show that economic growth is mainly promoted by the secondary industry.The uncoordinated factors exist in the industry structure,the primary and the third industry did not develop fully,while the secondary industry especially the traditional industry developed too much and the proportion of them were more higher.Meanwhile,the modern service industry developed slowly.Based on the results,in order to optimize industry structure and increase the competitiveness of the whole industry,the following countermeasures and proposals should be put forward:improving industry diversification,strengthening modern agricultural ecologization and efficiency,facilitating the service industry modernization,forming the pattern of coordinated development in the whole industries and so on.
Exploring new genetic causes and pathological mechanisms of epileptic focal cortical dysplasia

Focal cortical dysplasia (FCD) is a rare, genetic, non-syndromic developmental malformation of the cerebral cortex that accounts for 5-10% of patients with focal epilepsy. FCD represents the main cause of pharmacologically intractable epilepsy, the only treatment available consisting of invasive surgical resection of the epileptogenic zone, which results effective in only 62% of patients. Thus, a better understanding of this disorder is necessary to develop more effective and less invasive treatments. FCD type 2 (FCD2) is an mTORopathy caused by genetic mutations that cause hyperactivation of the mTOR pathway, leading to abnormal cell size (cytomegalic dysmorphic neurons and balloon cells) and disruption of the structure of the cortex. Recently, the supervisor S. Baulac and others have partially explained the focal nature of the disorder by identifying post-zygotic somatic (mosaic) mutations in a percentage of cells that correlates with the size of the lesion. Despite this, the underling genetics remains unknown for ~40% of FCD2 patients. My first objective is to perform deep whole-exome sequencing of a cohort of 60 unsolved FCD2 cases to explore alternative pathways and find possibly pathogenic variants, focusing on those with an established link with mTOR pathway and/or neurodevelopment. Abnormal cells found in FCD2 lesions have been hypothesized as the source of the epileptogenic activity. However, the developmental origins of these cells are still unclear, and there is a need to find clear biomarkers that can clarify the link between mTOR hyperactivation and neuronal hyperexcitability. This project aims to clarify these aspects by applying my expertise in single cell genomics and S. Baulac’s expertise in functional studies and disease modelling in human brain organoids. The MSCA IF will allow me to reintegrate in Europe after a 4-years+ postdoc in the US and complete my training with the objective of applying to set up my own lab at the end of the two years.
Self-medication patterns and drug use behavior in housewives belonging to the middle income group in a city in northern India

<b>Objectives:</b> The objective was to assess the self-medication patterns and drug use behavior in housewives belonging to the middle income group in a city of Haryana State in Northern India. <b>Materials and Methods:</b> A detailed questionnaire designed to assess the self-medication patterns and drug use behavior and interview technique was used to elicit the requisite information. One hundred housewives of the middle income group were interviewed in Rohtak. <b>Results:</b> Most of the housewives were in the habit of keeping the medicines though only 73% of them were in the habit of using it without any prescription. Also it was seen that those housewives who were taking self-medication were better educated than those not indulged in self-medication. All of them were using allopathic drugs on a regular basis while other modes of medications were less used. The self-medication was most commonly based on the previous prescriptions issued by the doctors followed by the suggestions from friends, advertisement on the television, and newspapers. For most of them the reasons for self-medication were financial restraints and lack of time to go to the medical practitioner. <b>Conclusions:</b> The study delineates the difference in the self-medication patterns and drug use behavior in housewives in a city of Northern India. The results emphasize the need for comprehensive measures for intervention strategies to promote rational drug therapy by improving prescribing patterns and influencing self-medication.
Discovery of Bacterial Fatty Acid Synthase Type II Inhibitors Using a Novel Cellular Bioluminescent Reporter Assay

ABSTRACT Novel, cellular, gain-of-signal, bioluminescent reporter assays for fatty acid synthesis type II (FASII) inhibitors were constructed in an efflux-deficient strain of Pseudomonas aeruginosa and based on the discovery that FASII genes in P. aeruginosa are coordinately upregulated in response to pathway disruption. A screen of 115,000 compounds identified a series of sulfonamidobenzamide (SABA) analogs, which generated strong luminescent signals in two FASII reporter strains but not in four control reporter strains designed to respond to inhibitors of pathways other than FASII. The SABA analogs selectively inhibited lipid biosynthesis in P. aeruginosa and exhibited minimal cytotoxicity to mammalian cells (50% cytotoxic concentration [CC 50 ] ≥ 80 μM). The most potent SABA analogs had MICs of 0.5 to 7.0 μM (0.2 to 3.0 μg/ml) against an efflux-deficient Escherichia coli (Δ tolC ) strain but had no detectable MIC against efflux-proficient E. coli or against P. aeruginosa (efflux deficient or proficient). Genetic, molecular genetic, and biochemical studies revealed that SABA analogs target the enzyme (AccC) catalyzing the biotin carboxylase half-reaction of the acetyl coenzyme A (acetyl-CoA) carboxylase step in the initiation phase of FASII in E. coli and P. aeruginosa . These results validate the capability and the sensitivity of this novel bioluminescent reporter screen to identify inhibitors of E. coli and P. aeruginosa FASII.
Protection, promotion and touristic valorisation of Adriatic maritime heritage

The main aim of the project is the development of a common tourism product, based on the principles of social and ecological sustainability which, at the same time, valorises, preserves, protects and promotes the rich maritime heritage of the border area. Within the area of the included partners, the project will maximally protect the existing material and intangible maritime heritage and systematically exploit it through a series of measures, in order to develop and revive a common tourism product. Cross-border cooperation multiplies the effect, because the common development guarantees a grater quality, successfulness and exchange of tourists. Maritime heritage is a large, unexploited tourism potential for both countries, which are rich in small-medium coastal cities with presence of local ports most of time representing authentic "treasures" with great potential appeal, and to be therefore enhanced and preserved. Integral cross-border cultural-tourism products will connect contents, and increase the economic, social and cultural cross-border exchange. Tourism subjects will promote two cross-border regions as one integral cross-border destination, by promoting the regions similarities and the complementarities of the common cultural offer based on maritime heritage of local ports.
Interregional Electromobility Networks for intERurban low carbon MOBility

In recent years, the European policies on the deployment of alternative fuels are acting as a driving force to several EU projects to promote sustainable mobility through the enabling of electric vehicles to circulate at least in urban/suburban agglomerations and other densely populated areas._x000D_
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The ADRION area is featured by an inadequate coverage and accessibility of public charging infrastructures in order to enable electric vehicles to circulate in the ADRION regions, not to mention the lack of common standards needed for the operation of such infrastructure. Such criticality generates a limitation for the medium and long range trips within the ADRION regions for the use of electric vehicles._x000D_
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In this framework, the ENERMOB project aims to study and support common solutions for electric transport systems at interurban and interregional level, by implementing pilot networks of charging infrastructures and by assessing sustainable technologies to manage energy demand of electric mobility._x000D_
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The project mainly aims to promote the use of electric vehicles in the existing regional/local transport systems of the ADRION area according to interregional common guidelines and to capitalize on experiences of already tested projects and actions by more advanced EU States._x000D_
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Moreover the project will develop pilot actions to test longer connections between different cities with the use of electric vehicles, by checking possible problems in the driving and charging phases._x000D_
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To reach the project objectives, ENERMOB involves mainly regional and local authorities that can plan and implement pilot actions and small-scale investments. Project will also focus on the implementation of coordinated strategies through the use of common technologies and standards._x000D_
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Within their main outputs, the project will develop a pilot model of transnational electric transport network connecting parallel local networks of electric vehicle supply equipment, in order to overcome interurban and interregional restrictions.
Disseminated Staphylococcal Disease in Healthy Children—Experience from Two Tertiary Care Hospitals of West Bengal

To assess the etiology, precipitating factors, treatment and outcome of disseminated staphylococcal disease (DSD) in healthy immunocompetent children.This hospital based observational prospective study was conducted in two tertiary care hospitals of West Bengal, India during the period of March, 2011 through February, 2012. Inclusion criteria were 1) children between 1 and 12 y and 2) clinical features DSD characterized by i) involvement of at least two distant organs with presence of gram positive cocci in clusters and/or growth of Staphylococcus aureus from at least one normally sterile body fluid, ii) fever, persistent bacteremia despite antibiotics and focal involvement of two or more separate tissue sites (skin, bone, joint, kidney, lung, liver, heart).Thirty six cases fulfilled the criteria of DSD with mean age in years 6.03 ± 3.04 (range 1-12). The age group of 5-12 y was found to be more vulnerable (p < 0.001). Septic arthritis following accidental blunt closed trauma, was the significant precipitating factor for DSD in this age group (p = 0.031). Methicillin resistant Staphylococcus aureus (MRSA) was the causative agent in all the cases. Vancomycin resistant Staphylococcus aureus (VRSA) was detected in 88.9 % of cases. All cases were sensitive to linezolid. No significant side effects were observed with 28 d of linezolid therapy.DSD is more common in 5-12 y age group. Trauma is a significant precipitating factor for DSD in this age group. Linezolid may be considered as the first line drug in DSD with MRSA.
Friction stir processing based local damage mitigation and healing in aluminium alloys

ALUFIX proposes an original strategy for the development of aluminium-based materials involving damage mitigation and extrinsic self-healing concepts exploiting the new opportunities of the solid-state friction stir process. Friction stir processing locally extrudes and drags material from the front to the back and around the tool pin. It involves short duration at moderate temperatures (typically 80% of the melting temperature), fast cooling rates and large plastic deformations leading to far out-of-equilibrium microstructures. The idea is that commercial aluminium alloys can be locally improved and healed in regions of stress concentration where damage is likely to occur. Self-healing in metal-based materials is still in its infancy and existing strategies can hardly be extended to applications. Friction stir processing can enhance the damage and fatigue resistance of aluminium alloys by microstructure homogenisation and refinement. In parallel, friction stir processing can be used to integrate secondary phases in an aluminium matrix. In the ALUFIX project, healing phases will thus be integrated in aluminium in addition to refining and homogenising the microstructure. The “local stress management strategy” favours crack closure and crack deviation at the sub-millimetre scale thanks to a controlled residual stress field. The “transient liquid healing agent” strategy involves the in-situ generation of an out-of-equilibrium compositionally graded microstructure at the aluminium/healing agent interface capable of liquid-phase healing after a thermal treatment. Along the road, a variety of new scientific questions concerning the damage mechanisms will have to be addressed.
Hidden hunger, forgotten food

Food Security is a grand challenge of our time, but three factors inhibit our ability to meet global targets. First, interdisciplinary approaches incorporating ecological, social, and health sciences are fundamental, but lacking. Second, a disproportionate focus on food quantity overlooks ‘hidden hunger’, or micronutrient deficiencies, which are implicated in over a million deaths annually. Third, small-scale fisheries (SSF) reach 100s of millions of people in the developing world, hold potential for achieving food security, but remain ‘forgotten food’ in global discourse. Consequently, an interdisciplinary approach that tackles hidden hunger within SSF is a critical frontier for food security research.

Fish are particularly high in many micronutrients, but a systematic understanding of which species have the greatest concentrations of key nutrients is needed. Inadequate access to nutritious food is one of the most significant problems of the modern age, which can be illuminated through analyses of power. The failure to realise the tremendous potential for improving food security through fisheries stems from a lack of understanding of how social drivers exacerbate or ameliorate nutritional inequalities. Consequently, an in-depth analysis that quantifies how key social drivers impact nutritional inequality, is essential.

FAIRFISH will address these gaps to uncover the ecological and socio-cultural determinants of the contributions SSF make to human health:
1. Establish the ecological and environmental determinants of nutrient availability among fish species using a traits based approach. 
2. Advance social practice theory, by integrating an analysis of power, to determine what power relations enable or constrain access to nutritious food. 
3. Progress interdisciplinary science, by integrating findings from 1 and 2, to quantify the impact of key social drivers on nutritional inequality, and uncover opportunities to meet nutritional needs.
Publica auctoritas, impudicitia e apresentação do corpo em duas controversiae de Sêneca o Reitor

Neste trabalho são examinados dois acontecimentos narrados nas controversiae de Sêneca (o Reitor), relacionados a diferentes situações interligadas pela sanção que o autor julgou ser aplicável a apresentações inadequadas do corpo, tanto em relação a um cidadão particular – o caso do adolescente que sai de casa à noite vestido de mulher e que, portanto, pode eventualmente ser considerado vítima de stuprum cum vi – quanto a um magistrado no exercício de suas funções – aquele que, na atividade de jus dicere, usa roupas que não condizem com o ofício que possui. A utilização de fontes retóricas de natureza didática é de grande interesse, pois permite exercícios modelados a partir de possíveis casos reais, com os quais os amantes da arte dialética são convidados a se entreter, ora representando o papel de acusação, ora o de defesa. Busca-se demonstrar que a apresentação pública do corpo, se realizada em violação ao código de vestimenta socialmente aceito, produzia na Roma Antiga consequências jurídicas significativas, como a privação do direito de falar em assembleia pública (contio) ou, no caso de o magistrado ter ofendido, com seu traje, a respeitabilidade da res publica, a imputação de crimen maiestatis.
Affect-insensitive speaker recognition systems via emotional speech clustering using prosodic features

Voice-based biometric security systems involving only neutral speech have achieved promising performance. However, the speakers are very likely to fail the recognition when the test data exhibit multiple emotions. This paper aimed to address the mismatch of the emotional states between training and testing speech. We discuss different modeling strategies that incorporate the emotions (affects) of speakers into the training stage of a Mandarin-based speaker recognition system and propose an alternative approach, which could optimize the utilization of the limited affective speech. The training speeches are partitioned and clustered by the trends of the prosodic variations. Multiple models are built based on the clustered speech for a given speaker. The prosodic differences are characterized by a combination of features that describe the changes of the fundamental frequencies and energy contours. The experiments were carried out based on the Mandarin Affective Speech Corpus. The result shows 73.37 % improvement in recognition rate over that of the traditional speaker verification tasks relatively and also achieves 63.53 % higher in performance over the structural training-based systems relatively.