SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Drift sands, lakes, and soils: the multiphase Holocene history of the Laarder Wasmeren area near Hilversum, the Netherlands

Abstract A unique complex of multiphased Holocene drift sands and paleosols, with at least two lacustrine phases, was discovered during a major sanitation project in the Laarder Wasmeren area near Hilversum, the Netherlands. The complex could be studied in detail, highly facilitated by the excellent and large-scale exposure of the various deposits and soils. OSL dating was used to establish ages of the phases, where possible differentiating between time of deposition and time of burial by taking into account the potential effects of bioturbation. Pollen analysis served to reconstruct the vegetation during the various phases. A first minor phase of aeolian activity already started before approx. 5,000 BC, followed around 4,000 BC by a second phase and a rather massive third phase around 3,000 BC. After a long phase of soil formation, the latest, massive drift sand phase started around the 14th to 15th century. It clearly represents the classic drift sand phase that started in the Late Middle Ages in the Netherlands. Sand drifting followed on soil forming phases during which the vegetation became increasingly dominated by ericaceous plants and culminated in heathlands. The first three aeolian phases and associated heathlands are much older than generally assumed for heathland and drift sand to occur in the Netherlands. Moreover, podzolisation was found to have started very early, true podzols already occurring before 4,000 BC. Around 3,000 BC groundwater in the area reached a maximum altitude of about 230 cm +NAP, resulting in local open water in the area. This rise is probably linked to the development of the Dutch coastal area, where at that time peat accumulated and drainage was poor, inducing a rise of the groundwater level in ‘het Gooi’. This groundwater level fell later on, to never reach this altitude again. The Groot Wasmeer was formed by local stagnation on a slowly permeable podzol and already reached a level of 320-325 cm +NAP by 400 BC, which more or less equals its 20 th century level. The results demonstrate that earlier concepts on the occurrence and age of aeolian phases, podzols and heathland vegetations in the Netherlands are far too schematic, and that early, pre-agricultural cultures may already have had an impact on the stability of fragile cover sand landscapes, e.g. through burning. Results are in line with those from several contemporary studies on early prehistoric cultures and their impact in river dune areas in the Central and Eastern Netherlands.
The Tight Oil Accumulation Model and Geological Characteristics in Continental Sedimentary Basins of China

The exploration practices in recent years confirmed that tight oil is widely distributed in continental sedimentary basins of China. Some significant discoveries have been obtained in Ordos basin, Junggar basin and Songliao basin, etc. At present the cognition degree about tight oils in China is still relatively low. This paper divided tight oil into four accumulation models, three matching relationships of source and reservoir and two reservoir types of sandstone and carbonate rock, according to the lake-level fluctuation and sediment supply, saline lacustrine basin depositional feature, development and disposition relationship of source rock and reservoir as well as tight reservoir lithology, etc. Also, this paper analyzed the geological characteristics of scale and physical properties of tight reservoirs, and discussed their significances for petroleum exploration for the purpose of providing references for China's continental tight oil exploration.
Active organotypic models for nanoparticle toxicological screening

Nanoparticles and new drugs are undergoing complex toxicity evaluation prior to their use in products for customers.
However, the traditional pre-clinical testing protocols are delivering significant disadvantages both from ethical (animal
testing) and functional (high attrition rate in clinical testing) point of view. ActiTOX reacts to this problem by the development
of a novel, pre-clinical, high content, in vitro testing platform focused on the evaluation of nanoparticles/drugs via ADME
(absorption, distribution, metabolism, excretion) toxicity studies. In order to advance the current state of art the project will
employ biomimetic scaffolds, drug delivery systems, human induced pluripotent stem cells (iPSCs), 3D-microfluidics and
modular bioreactor technology. ActiTOX aims to increase the relevance of in vitro studies and provide a scalable approach
for their use in drug development and toxicological screening.
In order to achieve the project goals, a training network enabling efficient short-term secondments of ER and ESR between
academia and industry will be established. The cooperation between stakeholders helps closing the gap between them and oint innovation to foster the current state of the art. ActiTOX will mediate it via networking, research, training, workshop,
innovation and dissemination actions in form of short-term secondments. The project fulfils the aim of a RISE project and
delivers significant social impact, increases knowledge based economy and creates long lasting cooperation strengthening
the European research area.
Woven and 3d-printed thermoelectric textiles

Imagine a world, in which countless embedded microelectronic components continuously monitor our health and allow us to seamlessly interact with our digital environment. One particularly promising platform for the realisation of this concept is based on wearable electronic textiles. In order for this technology to become truly pervasive, a myriad of devices will have to operate autonomously over an extended period of time without the need for additional maintenance, repair or battery replacement. The goal of this research programme is to realise textile-based thermoelectric generators that without additional cost can power built-in electronics by harvesting one of the most ubiquitous energy sources available to us: our body heat.

Current thermoelectric technologies rely on toxic inorganic materials that are both expensive to produce and fragile by design, which renders them unsuitable especially for wearable applications. Instead, in this programme we will use polymer semiconductors and nanocomposites. Initially, we will focus on the preparation of materials with a thermoelectric performance significantly beyond the state-of-the-art. Then, we will exploit the ease of shaping polymers into light-weight and flexible articles such as fibres, yarns and fabrics. We will explore both, traditional weaving methods as well as emerging 3D-printing techniques, in order to realise low-cost thermoelectric textiles.

Finally, within the scope of this programme we will demonstrate the ability of prototype thermoelectric textiles to harvest a small fraction of the wearer’s body heat under realistic conditions. We will achieve this through integration into clothing to power off-the-shelf sensors for health care and security applications. Eventually, it can be anticipated that the here interrogated thermoelectric design paradigms will be of significant benefit to the European textile and health care sector as well as society in general.
Synergistic Antibacterial Activity of Ecklonia cava (Phaeophyceae: Laminariales) against Listeria monocytogenes (Bacillales: Listeriaceae)

In an effort to discover alternative antimicrobials against Listeria monocytogenes, several marine algae were screened. The methanolic extract of Ecklonia cava exhibited the highest antibacterial activity against L. monocytogenes, with the ethyl acetate (EtOAc) soluble fraction of E. cava methanolic extract having a MIC value of 256 μg/mL and a MBC value of 512 μg/mL. The MIC values of streptomycin in combination with the EtOAc fraction were markedly reduced up to 64-fold, suggesting that the antibacterial activity of the antibiotic was restored when combined with the EtOAc fraction. The interaction between streptomycin and the EtOAc fraction was assessed by fractional inhibitory concentration (FIC) indices. The combination of streptomycin and the EtOAc fraction against L. monocytogenes resulted in ∑FICmin range of 0.141 to 0.266 and ∑FICmax of 0.531 for all strains. The median ∑FIC against L. monocytogenes strains ranged from 0.172 to 0.344. Thus, synergistic ranges of FIC <1 were observed for all combinations of streptomycin and the EtOAc fraction against L. monocytogenes strains. Indeed, the median ∑FIC of streptomycin–EtOAc fraction ranged from 0.172 to 0.344, suggesting a marked synergy.
Glamping Skies

O projeto Glamping Skies representa a inovação no turismo, conjugando tradições e modernidade.É um parque campismo de Domes, unidades turísticas com capacidade para 2 pessoas, onde as funcionalidades de um hotel de 4 estrelas se associam à comunhão com a natureza, através de uma estrutura única.
Impact of new physics on the EW vacuum stability in a curved spacetime background

It has been recently shown that, contrary to an intuitive decoupling argument, the presence of new physics at very large energy scales (say around the Planck scale) can have a strong impact on the electroweak vacuum lifetime. In particular, the vacuum could be totally destabilized. This study was performed in a flat spacetime background, and it is important to extend the analysis to curved spacetime since these are Planckian-physics effects. It is generally expected that under these extreme conditions gravity should totally quench the formation of true vacuum bubbles, thus washing out the destabilizing effect of new physics. In this work we extend the analysis to curved spacetime and show that, although gravity pushes toward stabilization, the destabilizing effect of new physics is still (by far) the dominating one. In order to get model independent results, high energy new physics is parametrized in two different independent ways: as higher order operators in the Higgs field, or introducing new particles with very large masses. The destabilizing effect is observed in both cases, hinting at a general mechanism that does not depend on the parametrization details for new physics, thus maintaining the results obtained from the analysis performed in flat spacetime.
Have Accounting Standard Changes Improved Usefulness of Credit Decision in Parent Company’s Statement? From the Perspective of Debt Maturity Structure

The present financial reports in China include both the consolidated statements and the parent company’s statements.Taking A share of non-financial firms in the period from 2004 to 2009 as samples,this paper investigates the impacts of accounting standard changes on the usefulness of credit decisions in the parent companies statements.The research results indicate that the parent company’s statements under the formal standards provide the creditor with no incremental information in addition to the consolidated statements.When the new standard is implemented,the content of incremental information in the parent company’s statements is improved significantly.Further study indicates that the effect of accounting standard changes on the usefulness of accounting information will be affected by the demand for accounting information.
Direct measurements of key nuclear reactions for the creation of elements in stars

The evolution of the universe has left an imprint in the form of the chemical elements. Understanding the cosmic origins of the elements remains a major challenge for science. The abundances of elements we see in our solar system, distant stars, meteorites, and in stellar explosions provide us with clues about how the elements came to be produced in a variety of different processes and stellar environments. To unravel these mysteries we need to understand the nuclear reactions producing and destroying the elements. New generation accelerator facilities and instrumentation are being developed in Europe which will enable many of these reactions to be measured directly for the first time, and with high precision. This offers the prospect of a major step forward in the field in the next few years. Many of the key reactions involve unstable nuclei, studied experimentally either by using radioactive beams or targets. These unstable nuclei play a critical role in high temperature stellar environments, most notably stellar explosions. Reactions can occur on the unstable nucleus before it has decayed thereby strongly altering the path of subsequent element synthesis. The proposal is sub-divided into 5 themes, concerning production of the heavy elements in neutron capture reactions, destruction of the cosmic gamma-ray emitter 26Al in core collapse supernovae, neutron source reactions in  stars, the puzzle of high abundances of proton-rich heavy isotopes, and the origin of nature’s least abundant isotope 180mTa. Experiments will initially be performed using neutron beams from the upgraded n_TOF facility at CERN including the high flux EAR-2 beam line, and using radioactive beams from the upgraded HIE-ISOLDE facility at CERN. In the later phase of the proposal experiments will also be performed using the new ultra-high intensity neutron beam facility FRANZ at Frankfurt, and with radioactive beams injected into heavy ion storage rings to be installed at GSI and CERN.
Nano engineered injectable biomaterials for osteoporotic bone treatment

My aim as an MSCA Individual Fellow is to tackle a devastating clinical orthopaedic challenge for which there is currently no reparative treatment, specifically osteoporotic vertebral fractures (OVFs), by developing an advanced biomaterial technology to restore structural integrity and function of disease-damaged bone. The scientific goal of this proposal is to develop a novel therapeutic injectable nanomaterial technology for OVFs repair. This will be achieved through an innovative research project that aims to implement a transformative strategy utilising antioxidant-ion substituted nano-particles (a-NPs) to target disease impaired osteoblast function and drive bone regeneration. In addition, an innovative biomaterial strategy will be employed, combining mechanically robust nano-silicates with a bioresorbable collagen matrix for local controlled release of therapeutic a-NPs, as a pioneering advance for OVFs treatment. As an ambitious postdoctoral fellow, the training objective of this fellowship is to attain the requisite scientific and complementary skills to successfully achieve my long-term goal of establishing an independent research programme that will contribute to Europe’s research & innovation capacity and reputation. This will be achieved through the expert supervision and input of Dr Ciara Murphy (Royal College of Surgeons in Ireland –RCSI), her colleagues in RCSI and collaborative research centre AMBER, and through research secondment with Prof Boccaccini (Friedrich-Alexander Universität Erlangen-Nürnberg). In addition, by managing the project, I will further develop skills relating to planning and reporting, financial management and dissemination. I will also avail of opportunities to supervise students in related projects. In summary, this Fellowship will provide invaluable help to establish an independent research niche in regenerative biomaterial development, while equipping me with the skills needed to embark on my independent research career.
Association of collagen with calcium phosphate promoted osteogenic responses of osteoblast-like MG63 cells

In this investigation, the effects of the association of the collagen (COLL) molecules with the calcium phosphate (CaP) film were examined with respect to both the physicochemical properties of the CaP films and the osteoblast responses, such as the adhesion, proliferation, differentiation, and mineralization. The COLL pre-adsorbed CaP film (CaPA) exhibited significant changes in the surface morphology compared to the COLL incorporated CaP film (CaPC). The adhesions of the osteoblast-like MG63 cells were similar on the CaPC or CaPA films. However, the proliferation of the MG63 cells on CaPC was comparable to CaP but considerably different than CaPA. The differentiation of the MG63 cells was greatly improved on CaPC and CaPA compared to CaP and more pronounced on CaPA. The presence of COLL within or on the CaP films significantly modulated the expression of the phenotypic genes, including osteopontin (OPN), alkaline phosphatase (ALP), and the transforming growth factor-β (TGF-β). The expression patterns of these genes elucidated that COLL that was present within or on the CaP film supported the osteoblast proliferation and differentiation. These positive effects were stronger for CaPA than CaPC. The bone-like nodules formed on all of the specimens. However, the mineralization of CaPC and CaPA was significantly higher than CaP, indicating that the association of CaP with COLL promoted the mineral deposition. Therefore, the association of the COLL molecules with the CaP film induced positive effects on the biomineralization. Overall, the incorporation of COLL efficiently enhanced the osteoblast responses of CaP. This system can be utilized in a drug delivery system using calcium phosphate. Although the incorporation effects were slightly higher for the osteoblast responses of CaPA than CaPC, CaPC can be used when the longer drug release times are desirable.
Heat Recirculation Effect on the Structure of Wood Dust Flame Propagation

A model for heat-recirculating micro combustor is developed. It investigates the structure of laminar, one-dimensional and steady state flame propagation in uniformly premixed wood particles with considering the effects of heat recirculation caused by configuration of micro combustor. The flame structure is divided into three regions: a preheat-devolatilization zone where the rate of the gas-phase chemical reaction is small; a narrow reaction zone where convection and the rate of devolatilization of the fuel particles are small; and finally a convection zone where diffusive terms in the conservation equation are small. In this model, it is assumed that the fuel particles vaporize first to yield a gaseous fuel of known chemical structure. The analysis is investigated in the asymptotic limit. The overall investigation of this study leads to a novel non-linear burning velocity correlation that heat recirculation term is considered to calculate it. The results shows that heat recirculation affect the flame structure by different parameters.
Reliability and validity of the dimensional features of generalized anxiety disorder

The reliability and validity of the dimensional features of generalized anxiety disorder (GAD) were examined in a diverse sample of 508 outpatients with anxiety and mood disorders who underwent two independent administrations of the Anxiety Disorders Interview Schedule for DSM-IV: Lifetime version (ADIS-IV-L; Di Nardo, Brown, & Barlow, 1994). Inter-rater reliability was higher in the full sample than in patients with current GAD. Additionally, the presence of a mood disorder weakened inter-rater reliability. We also explored the unique contribution of excessiveness and uncontrollability of worry to various clinical outcomes and found that excessiveness predicted anxiety, depression, and stress self-report measures, and uncontrollability predicted clinical severity and number of diagnoses. Findings are discussed with regard to their implications for the classification of GAD (e.g., utility of dimension-based assessment to improve the classification of psychological disorders).
Planning in the UK: An Introduction

Preface PART I: PLANNING AND THE PLANNING SYSTEM 1. Introduction: Why Planning Matters 2. The Organisation of Planning 3. The Control of Development and the Development Process PART II: THE STORY OF PLANNING 4. The Historical Roots of Planning 5. Industrialisation: Reaction and Reform 6. From Industrialisation to Globalisation 7. Planning into the New Millennium 8. The History of the Theories behind Planning PART III: THE SCOPE OF MODERN PLANNING 9. Planning for the Countryside and other Green Areas 10. Sustainable Development 11. Regeneration, Retail and Renewal 12. Transportation Planning 13. Urban Design, Place-Making and Culture PART IV: PLANNING AND PEOPLE 14. The Social Aspects of Planning 15. Planning For Diversity and Equality: Women and Minorities 16. Planning and the Built Environment Professions
Synthetic viability of homologous recombination-deficient cancers

Although various effective anti-cancer drug treatments have become available over the last decades, drug resistance remains the major cause of death of cancer patients. Striking examples are patients with tumors that are defective in DNA repair by homologous recombination (HR). Despite initial responses to cancer therapy, resistance of primary or disseminated tumors eventually emerges, which minimizes therapeutic options and greatly reduces survival. The molecular mechanisms underlying this therapy escape are often poorly understood.

In the SYNVIA project I will address the problem of therapy escape by using powerful genetically engineered mouse models for BRCA1- and BRCA2-deficient breast cancer, which closely mimic the human disease. Due to the BRCA inactivation, the tumors that arise lack HR-directed DNA repair. Similar to the situation in cancer patients, we observe that cancer cells in these models eventually escape the deadly effects of chemotherapy or novel targeted drugs. Thus, these resistance models provide a unique opportunity to explore therapy escape mechanisms.

I propose an approach that will take the in vivo analysis of therapy resistance mechanisms to a new level. By synergizing the advantages of next generation sequencing with functional genetic screens in tractable model systems, I will explore novel mechanisms that cause resistance of HR-deficient cancers by the loss of another gene (“synthetic viability”). I provide evidence that new mechanisms of resistance can be identified with this approach. In an innovative step, I will generate genome-wide alterations using the revolutionizing CRISPR/Cas technology. Mutations will also be introduced into 3D tumor organoid cultures, as we found that these are more physiologically relevant. I am convinced that the combination of these state-of-the-art approaches will yield highly useful information for designing effective approaches to circumvent or reverse therapy escape in human cancer patients.