SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Non-Coding rna and intercellular communication in cardiac ageing

Life expectancy in the European Union is rising and the prevalence of age-induced cardiovascular disease increases concomitantly. The main clinical presentation of age-induced cardiovascular disease is heart failure with preserved ejection fraction (HFpEF). HFpEF is a complex disease involving different cell types and mechanisms that contribute to impaired relaxation of cardiomyocytes. Currently there is no appropriate treatment for HFpEF. This proposal aims to better understand the molecular mechanisms behind intercellular communication and ageing that lead to HFpEF.
Long non-coding RNAs (lncRNAs) are emerging as novel key regulators of cellular functions and we hypothesize that lncRNAs contribute to ageing-induced cardiac dysfunction, including HFpEF. Preliminary experiments show that several long non-coding RNAs (lncRNAs) are differentially regulated during cardiac ageing, including the cardiomyocyte-enriched lncRNA Sarrah that is essential for cardiomyocyte survival. We propose to extensively characterize the role of Sarrah in HFpEF and to identify other lncRNAs that are involved in cardiac ageing. Importantly, we will focus those lncRNAs that are also affected in a cohort of human HFpEF patients. Furthermore, since disturbed intercellular communication is a hallmark of both ageing and HFpEF, we will identify lncRNAs that regulate endothelial cell-cardiomyocyte crosstalk. We will use state-of-the-art in vitro and in vivo models to assess cardiac ageing and function upon gain-of-function and loss-of-function of lncRNAs in a cell-type specific manner.
Understanding the role that Sarrah and other lncRNAs play in cardiac ageing and HFpEF will highlight novel potential therapeutic targets to attenuate age-induced cardiac dysfunction and will increase our knowledge of the underlying mechanisms controlling intercellular communication and cardiac function.
First principles molecular dynamics studies of elastic constants, ideal tensile strength, chemistry of crack initiation, and surface and cohesive energies in amorphous silicon

First principles Kohn–Sham density functional theory (DFT)-based molecular dynamics (MD) is employed to investigate some physical and mechanical properties of amorphous Si (a-Si) samples, as-quenched and annealed containing dangling and floating bonds as well as distorted tetrahedral bonds. The total energy and true stress as functions of the engineering strain for a-Si samples subjected to uniaxial tensile stress as well as uniaxial extension are obtained. It is well-known that the electron density of the state of matters can be determined via ab initio DFT-based MD with high accuracy. Using this technique, such inherent properties as the elastic constants, ideal tensile strength, ultimate tensile strength, and surface and cohesive energies will be calculated. Since the employed ab initio MD, in contrast to the empirical potentials simulations, is capable of providing the evolution of the electronic charge distribution, we can afford to study the chemistry of crack initiation and reconstructed surfaces a...
Efficient small scale unit for distributed heat and hydrogen generation

The project task is the development and validation of an efficient catalytic fuel processor as the key component of small
scale units for combined heat and power (CHP) generation in residential applications, based on hydrogen-fuel cells and fed by
natural gas, air and water. A critical issue of these devices is the intensification of the heat supply in the compact methane steam reformer
where hydrogen is generated. To this purpose we exploit the findings from my ERC AdG project INTENT, developing a
reformer design based on thermally conductive cellular structures packed with catalyst microparticles. As demonstrated
already in INTENT by lab scale tests, the flow independent conductive heat exchange mechanism enables a highly effective power
supply to the endothermic catalytic reaction even in the case of low and fluctuating flow rates, as typical of these compact
units.
The INSTANT project aims at testing this novel configuration of the fuel processor at a semi-industrial scale (TRL5). Indicators which will be evaluated during the test sessions include: 1) the H2 productivity for a given catalyst load (target = +30%); 2) the start-up time to full load (target = -30%); 3) the response time to a load change (target = -30%). Based on the experimental outcomes, INSTANT will also assess the potential for reducing the footprint of the CHP unit, the system volume being currently one of the main constraints for domestic CHP applications, as well as the overall production cost, including life-cycle costs. If successful, INSTANT will pave the way to a new generation of CHP systems based on hydrogen fuel cells, to be used in residential applications and, in perspective, in hydrogen refueling stations for fuel-cell vehicles, thus contributing to the decarbonisation of the EU energy system.
EXTRACTOS DE MICROBIOS DE RÁPIDO CRECIMIENTO

La presente invención se refiere al método para la producción de una composición que comprende al menos el 15% de nucleótidos, preferiblemente al menos el 18% de nucleótidos, más preferiblemente al menos el 22% de nucleótidos y al menos el 40% de aminoácidos y péptidos, y a una composición que comprende al menos el 15% de nucleótidos, preferiblemente al menos el 18% de nucleótidos, más preferiblemente al menos el 22% de nucleótidos y al menos el 40% de aminoácidos y péptidos obtenibles de acuerdo con dicho método. El método de la presente invención involucra obtener la biomasa al cultivar al menos una cepa(s) de microorganismo(s) caracterizada(s) por un índice de crecimiento en el proceso de al menos 0.85 h-1. La composición de la presente invención es particularmente útil en la producción de pienso para animales, alimento para mascotas, productos alimenticios, medios de fermentación o suplementos, nutracéuticos, farmacéuticos, diagnósticos, ARN o ADN, o potenciadores de sabor.
Ifact - iodine fed advanced cusp field thruster

Since several years, the industrialisation of the satellite market has been accelerated. In particular, the market for telecom satellites has changed significantly, because of several new players and numerous plans for satellite constellations, such as OneWeb or Starlink.
In order to increase competitiveness and to disrupt the electric propulsion market, we are proposing the development of the iodine Fed Advanced Cusp field Thruster (iFACT).

iFACT consists of an Advanced Cusp Field Thruster (ACFT), a simple PPU, a thermionic Emitter, a novel propellant feeding architecture, which is optimised for iodine. The ACFT has been invented by Airbus in 2017. Due to its simplicity, paired with efficiency, the fact that it is easy to ignite and its excellent performance data with iodine, it is tailored as key element for an extremely simple, efficient and low cost Electric Propulsion Subsystem (EPS). The baseline thruster (300 W input power) can be used with a simple thermionic cathode. The simple  operation of the ACFT enables a reduced (wrt. number of parts and control circuits) but efficient PPU. This components are paired with an unique iodine feeding architecture which is capable to disrupt the electric propulsion market.
Based on this, the proposal will focus on:
- Iodine as disruptive propellant for electric thruster,
- maturation of the Advanced Cusp Field Thruster (ACFT) as disruptive thruster principle, in three different power classes,
- development of an novel, disruptive, extremly simplified low cost Power Processing Unit (PPU),
- use of calcium aluminate (C12A7) as disruptive, low-work function emitter material for cathodes,
- development of an European Iodine compatible long firing test facility.
Estudo da análise granulométrica por peneiramento de minérios da região de Carajás - PA

O conhecimento da distribuição de tamanhos de um conjunto heterogêneo de partículas, chamado análise granulométrica, é uma importante ferramenta nos estudos de caracterização tecnológica de minérios, no controle de qualidade de um produto para comercialização, na seleção de equipamentos ou em processos de beneficiamento de minérios. Vários métodos foram desenvolvidos para essa finalidade, quase sempre, baseados na similaridade geométrica ou hidrodinâmica das partículas. Na análise granulométrica por peneiramento, método mais antigo e bastante utilizado na prática laboratorial, alguns fatores podem influenciar o resultado, como o tempo de peneiramento e a massa de material a ser analisada; pode ser a seco, a úmido ou combinado, vai depender da característica do material a ser ensaiado. No entanto, em laboratório, ainda é comum utilizar erroneamente massa e tempo padrões para diferentes materiais, sem levar em consideração suas particularidades (principalmente densidade). O objetivo principal deste trabalho é determinar a massa e o tempo adequados, nos ensaios de análise granulométrica por peneiramento, para os minérios de ferro e cobre da região de Carajás-PA. Utilizando a equação proposta por Gaudin, que determina a massa máxima que deve ficar retida em cada peneira, e ensaios sucessivos de peneiramento com tempos crescentes até que a massa passante em uma ou mais peneiras não varie mais do que 0,1%, espera-se encontrar a massa e o tempo adequados para cada minério estudado, contribuindo assim com as práticas laboratoriais do tratamento de minérios.
Il principio di nazionalità di Pasquale Stanislao Mancini nella scienza del diritto internazionale argentina tra i secoli XIX e XX

Il principio di nazionalità proclamato da Pasquale Stanislao Mancini nella prolusione del 1851 si colloca fra i tanti tentativi della scienza giuridica del secolo XIX di rispondere a fenomini politici propri di quel contesto storico. Tale principio viene esaminato nelle pagine della scienza argentina del diritto internazionale nei decenni posteriori in differenti modi, tra applausi entusiastici e critiche feroci. Lo scopo di questo articolo è svolgere la ricostruzione dell’itinerario percorso dalla proposta di Mancini nei dibattiti della dottrina argentina, tra autori favorevoli e contrari, sottolineando le principali motivazioni che hanno condotto ormai nel secolo XX al suo completo abbandono e conseguente storicizzazione. L’ipotesi qui presentata è quella secondo cui il processo di deleggittimazione e storicizzazione del Principio in Argentina sia avvenuto principalmente in ragione delle peculiarietà proprie della formazione storica di questa realtà statale, molto distante da quelle vissute nella costituzione di Stati europei come l’Italia, culla ed allo stesso tempo ispirazione della proposta manciniana.
Moire magnification device

A moire magnification device is disclosed, including a transparent substrate carrying: a regular array of micro-focusing elements on a first surface, the focusing elements defining a focal plane; and a corresponding first array of microimage elements located in a plane substantially coincident with the focal plane of the focusing elements. The pitches of the micro-focusing elements and the array of microimage elements and their relative locations are such that the array of micro-focusing elements cooperates with the array of microimage elements to generate magnified version of the microimage elements due to the moire effect. Along at least one axis across at least a first region of the device, the pitch between the microimage elements and/or between the micro-focusing elements continuously varies across the respective array(s), whereby the moire effect causes different degrees of magnification of the image elements to occur.
Difficulties Experienced by the Arab Teacher during His First Year of Teaching as a Result of Personal and Organizational Variables

This pioneer study deals with difficulties faced by the beginning Arab teacher. The theoretical framework of the research is based on Veenman’s (1984) analysis, which indicates 24 difficulties faced by the beginning teacher. These difficulties have been classified into eight categories ranked in order of importance. The study seeks to identify the difficulties experienced by the beginning Arab teacher during his first year of teaching and to predict his future dissatisfaction with teaching based on those difficulties. The questionnaire drafted especially for this study was completed by 130 participants (beginning teachers). The responses were analyzed, yielding six factors of difficulty. The findings indicate difficulties involving: 1) the interpersonal communication between beginning Arab teachers on the one hand and both students and parents on the other, 2) overload, 3) didactic and disciplinary knowledge, 4) support and recognition, 5) organizational climate (school culture), and 6) satisfaction. We examined the correlation between the beginning Arab teacher’s difficulties and his dissatisfaction with his work. The research findings reveal that the organizational climate (school culture) and overload factors significantly affect the satisfaction variable. With regard to the relation between the beginning Arab teacher’s general background characteristics and his difficulties in the first year, the background variable, specialization, was found to affect the factors of difficulty.
Unveiling the population of supermassive black hole binaries near merger

At the center of nearly every galaxy in the Universe lurks a supermassive black hole with mass millions to billions that of the Sun. When two galaxies collide,  their supermassive black holes sink to the center of the newly forming galaxy. There in this nascent galactic nucleus a supermassive black hole binary is formed. Supermassive binaries are the subject of a long standing mystery in astrophysics: will these monstrous black holes merge and what can that tell us about the extreme environments that shape them? I will make great strides towards solving this mystery through advancing the state of the art in simulations of interactions of supermassive black hole binaries and their gaseous environments. From these simulations I will predict binary orbital evolution rates as well as observational signatures of the interaction. I will use the former to build the most accurate binary population models to date and the latter to constrain these models via observational searches in the newest time domain data, possibly leading to the  first detections of these elusive black hole pairs.
METHOD FOR PRODUCING COATED PAPER WITH PEARLESCENT EFFECT

A method for producing coated paper with pearlescent effect, sequentially comprising the following operating steps: -- a deposition, on at least one side (2a) of a paper medium (2), of at least one layer (3a) of coating; -- an additional deposition, over the at least one layer (3a) of coating, of a coating (3b) with pearlescent effect by a rotogravure/flexographic device.
Abstract IA05: Clinical genomics alters care, informs new science

Broad-based prospective sequencing has begun to inform the care of individual cancer patients. Such genomically driven cancer medicine is facilitating the use of mechanism-based therapeutic approaches in patients. In addition to the value of such data to inform the treatment of individual patients under active clinical care, over time these accrue as unprecedented datasets of integrated genomic, clinical, and treatment response data that can inform translational cancer research. Here, we present preliminary results of our efforts to combine both large-scale retrospective and prospective sequencing data in cancer to drive translational cancer biology. We will report on our efforts to develop a computational oncology framework to mine these data not only for new treatment hypotheses that can be tested clinically and the preliminary results from those studies, but also how this is driving new approaches to understand so-called long tail mutations both biologically and clinically. These efforts lie at the interface of retrospective and prospective studies to inform precision oncology through new tools that move beyond enumerating individual genetic vulnerabilities toward interpreting their biological and clinical interpretation for the benefit of patients. Citation Format: Barry S. Taylor. Clinical genomics alters care, informs new science. [abstract]. In: Proceedings of the AACR Precision Medicine Series: Integrating Clinical Genomics and Cancer Therapy; Jun 13-16, 2015; Salt Lake City, UT. Philadelphia (PA): AACR; Clin Cancer Res 2016;22(1_Suppl):Abstract nr IA05.
Realizing a development platform for sustainable sun powered production of intermediates for chemical industry.

The objective is to develop a base cyanobacterial cell factory for terpene precursors that can be the development platform for commercial terpene production with cyanobacteria.

Trends such as growth in world population, higher energy and food demand, depletion of raw materials and global warming make it necessary to implement breakthrough bio-based production technologies. A breakthrough is the use of genetically engineered cyanobacteria that turn CO2 directly and efficiently into predetermined products when exposed to light. This CO2-consuming process is based on circular economy principles and independent of first generation (food crop) feedstocks.

A promising group of products for cyano-based production are terpenes and terpenoids. These compounds are of interest to chemical industry due to their potential of producing platform chemicals that are now obtained from fossil fuels. Terpenes have an advantage over other biobased commodities because they are drop-in chemicals that can be processed in much the same manner as crude oil.

Despite potential uses in the medicine, food and fragrance sectors, the natural abundance of terpenes is too low for industrial production. Many approaches have been sought to engineer microbial strains capable of producing terpenoids in high yields. Up to now these do not result in increased production rates to the high levels needed. The project addresses this problem by producing a cyanobacterial strain capable of synthesizing high-levels of cell metabolite building blocks as an avenue towards the terpene production.

The SME host, together with industrial partners, develops and markets cyano-based production technology. The fellow’s work will strengthen this and will give him the experience to establish a career in industrial R&D and entrepreneurship. A research and training program with ample industrial and academic interaction, supported by dissemination and communication actions, has been set up to realise this impact.
Sensitivity analyses and simulations of a full-scale experimental membrane bioreactor system using the activated sludge model No. 3 (ASM3)

An ASM3-based model was implemented in the numerical software MATHEMATICA where sensitivity analyses and simulations of a membrane bioreactor (MBR) system were carried out. These results were compared with those obtained using the commercial simulator WEST. Predicted values did not show significant variations between both software and simulations showed that the most influential operational conditions were influent flow rate and concentrations and bioreactor volumes. On the other hand, sensitivity analyses were carried out with both software programs for the same five outputs: COD, ammonium and nitrate concentrations in the effluent, total suspended solids concentration and oxygen uptake rate in the aerobic bioreactor. Similar results were in general obtained in both cases and according to these analyses, the most significant inputs over the model predictions were growth and storage heterotrophic biomass yields and decay coefficient. Other parameters related to the hydrolysis process or to the autotrophic biomass also significantly influenced model outputs.
Evaluating inhaler use technique in COPD patients

Poor inhalation techniques are associated with decreased medication delivery and poor disease control in chronic obstructive pulmonary disease (COPD). The purpose of this study was to evaluate techniques for using inhaler devices in COPD patients.A prospective cross-sectional study was conducted to assess patient compliance with correct techniques for using inhaler devices across four regimens, ie, the pressurized metered-dose inhaler (pMDI), the pMDI with a spacer, the Accuhaler, and the Handihaler. The percentage of compliance with essential steps of correct device usage for each regimen was recorded without prior notification when COPD patients presented for a routine visit, and 1 month after receiving face-to-face training. We compared the percentage of compliance between the devices and risk factors related to incorrect techniques using logistic regression analysis. Percentage of patient compliance with correct techniques was compared between the two visits using the chi-square test. Statistical significance was set at P<0.05.A total of 103 COPD patients (mean age 71.2±9.2 years, males 64.1%, low education level 82.5%, and percent predicted forced expiratory volume in 1 second 51.9±22.5) were evaluated. Seventy-seven patients (74.8%) performed at least one step incorrectly. Patients using the Handihaler had the lowest compliance failure (42.5%), and the odds ratio for failure with the other devices compared with the Handihaler were 4.6 (95% confidence interval [CI] 1.8-11.8) for the pMDI, 3.1 (95% CI 1.2-8.2) for the pMDI with a spacer, and 2.4 (95% CI 1.1-5.2) for the Accuhaler. Low education level was the single most important factor related to incorrect technique (adjusted odds ratio 4.1, 95% CI 1.2-13.4, P=0.022). Formal training resulted in a statistically significant decrease in percentage of incorrect techniques for all devices and for the pMDI (59.4% vs 48.6%, P<0.001; 72.4% vs 48.3%, P=0.039, respectively).Inhalation technique in COPD patients without face-to-face training was mostly unsatisfactory, especially in patients with low education levels. The Handihaler was the inhaler device associated with the lowest technique failure. Face-to-face inhalation technique training significantly increased technique compliance for the pMDI.
Evaluation of a Summer Reading Program to Reduce Summer Setback

Summer setback, which is defined as a decline in academic achievement over the summer months, occurs in many academic areas but seems especially problematic in reading. We assessed students from a midwestern parochial school serving predominantly students from a low–socioeconomic status background for their reading achievement before they left for summer break in the spring and again at the start of the school year in the fall. We observed a significant decline in reading achievement. However, we observed a reduction in the effects of the setback in students who participated in a 3-week summer reading program that incorporated evidence-based reading fluency and comprehension strategies. Participants in the program significantly increased their reading achievement over the course of the summer program and started the school year with percentile ranks in reading that were higher than those at the end of the previous school year.
Quantum limits on postselected, probabilistic quantum metrology

Probabilistic metrology attempts to improve parameter estimation by occasionally reporting an excellent estimate and the rest of the time either guessing or doing nothing at all. Here we show that probabilistic metrology can never improve quantum limits on estimation of a single parameter, both on average and asymptotically in number of trials, if performance is judged relative to mean-square estimation error. We extend the result by showing that for a finite number of trials, the probability of obtaining better estimates using probabilistic metrology, as measured by mean-square error, decreases exponentially with the number of trials. To be tight, the performance bounds we derive require that likelihood functions be approximately normal, which in turn depends on how rapidly specific distributions converge to a normal distribution with number of trials.