SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Improved breast cancer care by innovative diagnostic test mammaprint

Agendia NV, a Dutch SME, was founded in 2003 as spin-off from the Netherlands Cancer Institute. They pursue the commercialization of molecular diagnostics using DNA microarray technology for cancer. Agendia aims to be one of the key market players in genomic breast cancer profiling. One of the products Agendia is developing is MammaPrint, a breast cancer recurrence test. This test identifies the risk of recurrence of cancer after surgical treatment, so that the appropriate adjuvant treatment can be selected personalized on the patients tumor characteristics. 

Breast cancer is the most commom cancer in the world and the principle cause of death of cancer among women worldwide. Currently guidelines recommend that adjuvant therapy is to be considered for all patients with early invasive breast cancer after surgery. However this 'one size fits all approach' leads to a proportion of patients being over- or under treated as the risk of recurrence is difficult to determine. The advancements in molecular diagnostics are starting to improve the prognosis and treatment of breast- and other cancers. MammaPrint is a molecular diagnostic based on analyzing the entire human genome. Agendia’s solution therefore enables better clinical decisions, reducing over- and under-treatment and therefore leading to better health outcomes and less costs.

MammaPrint can be used for all early stage breast cancer patients, which is unique in the field of breast cancer recurrence tests. As MammaPrint will be developed for more accurately identifying which breast cancer patients will gain the most benefit of adjuvant chemotherapy, the potential market for introducing MammaPrint is worldwide. In order to reach this full scale adoption, this project is focused to achieve the last clinical evidence for the clinical utility of this test needed for the uptake in EU and US clinical guidelines and reimbursement arrangements. This uptake is necessary for adoption of MammaPrint by physicians worldwide.
Lobbying for wealth redistribution by changing the social planner’s preferences

Wealth redistribution in a society is related to the social planner’s beliefs about social justice. In this paper, the social planner’s preferences are described by a Choquet integral, which is a convex combination of a weighted utilitarian social welfare function and an egalitarian social welfare function. By spending resources on lobbying, interest groups can change the social planner’s preferences, by shifting the weights of the utilitarian part, or by shifting more or less weight to the egalitarian part. We use a model of a two-player lobbying game and obtain the conditions for a pure strategy Nash equilibrium of the game.
SOUND INSULATION PANELS HAVING HIGH INTERLAYER THICKNESS FACTORS

A multiple layer panel having improved sound insulation is disclosed. The multiple layer panel comprises a first rigid substrate having a first thickness H3, a second rigid substrate having a second thickness H1, wherein H3 ≤ H1, and a multiple layer acoustic interlayer having a thickness H2 between the first and second rigid substrates.
Development of diesel engine sliding bearing wear test system

Aiming at the problems of bearing shell wear,in order to study the influence mechanism of sliding bearing wear,one sliding bearing wear test system was developed because existing equipment can't satisfy test requirement. The engine bearing such as main bearing shell and connecting rod bearing shell wear properties could be tested by this test system,under different structure,different rotating speeds,different lubricating oil condition,different abrasive particle and loads. The five subsystems as lubricating system,test control system,hydraulic system,mechanical bearing system and control system were introduced based on the study of test method. The load on analog axis was applied by hydraulic system. The motor speed was controlled by VFD. Lubricating oil pressure and temperature could be adjusted freely. The automation control of the test system,displaying in real time for the test data and the collection and preservation was achieved by the LabVIEW software. The wear test under different working conditions was achieved in the test system.The results indicated that the test system of which the function can be realized,and has a good performance and reached the expect goal.
METHOD AND DEVICE FOR WRITING AND READING A BUFFER MEMORY

The invention relates to a method for writing and reading a buffer memory. Said buffer memory has an input for write data and an output for read data. The output of a first addressing device addresses a memory cell of the buffer memory to be inscribed as the write pointer and the output of a second addressing device addresses a memory cell of the buffer memory to be read as the read pointer. The first addressing device and the second addressing device are controlled by a plurality of input signals in such a manner that the word length of the write data and the word length of the read data are adjusted independently of each other.
Observations of a Large-Amplitude Internal Wave Train and Its Reflection off a Steep Slope

Abstract Remote and in situ field observations documenting the reflection of a normally incident, short, and large-amplitude internal wave train off a steep slope are presented and interpreted with the help of the Dubreil–Jacotin–Long theory. Of the seven remotely observed waves that composed the incoming wave train, five were observed to reflect. It is estimated that the incoming wave train carried Ei = (24 ± 4) × 104 J m−1 to the boundary. The reflection coefficient, defined as the ratio of reflected to incoming wave train energies, is estimated to be R = 0.5 ± 0.2. This is about 0.4 lower than parameterizations in the literature, which are based on reflections of single solitary waves, would suggest. It is also shown that the characteristics of the wave-boundary situation observed in the field are outside the parameter space examined in previous laboratory and numerical experiments on internal solitary wave reflectance. This casts doubts on extrapolating current laboratory-based knowledge to fjord-like systems and calls for more research on internal solitary wave reflectance.
CO2-Neutral Transport for the Alpine Space (CO2-NeuTrAlp)

Alternative propulsion technologies for transport on the basis of renewable energies (RE) shall be implemented by local users of the Alpine Space: 1.) A variety of solutions will be applied in regions with differing resource potentials; 2.) Technical solutions will be harmonised in order to set international standards; 3.) Transnational exchange of know-how promotes the competitiveness of the Alpine Space. Through the use of new technologies of propulsion based on RE, the region will promote the independency from energy imports, job creation in (rural) areas, and the dynamics and competitiveness of Alpine SMEs. In partnership with experts from research and private business public authorities and transport companies will be enabled to test in pilot projects different available propulsion technologies in varying local applications. Those solutions will be analysed according to applicability, cost efficiency, local environmental footprint, ecological and economical effects.
REACTION VESSEL

A method of adapting an axial flow reaction vessel having opposed ports to an opposed axial flow reaction vessel is described comprising installing process fluid collection means within the body of the vessel in fluid communication with one or more of said ports.
A political economy of tax havens

The welfare effect of the existence of tax havens on high-tax countries has not been conclusive in the theoretical literature. Some papers show that the existence of tax havens is harmful to high-tax countries, while other studies argue that the opposite could occur. We aim to address a question: Do these welfare-reducing or welfare-enhancing properties still hold in the presence of lobbying? We find that the welfare-enhancing property does not hold, provided that the policy-maker attaches a sufficiently large weight to the political contribution received. Moreover, we point out that the cooperation among high-tax countries in restricting the international tax planning activity can lead to a lower level of social welfare in all high-tax countries.
The Design and Realization of Apple Orchard Intelligent Monitoring System Based on Internet of Things Technology

In order to reduce management costs of apple orchards, improve product quality of apples, and provide detailed, comprehensive and accurate electronic information for planting works, pest warning, and production quality tracking of apples, with the application of wireless sensor technology, by applied Zigbee technology, GPRS technology and IOT technology, on the basis of realization of apple orchard environment monitoring, this paper provides a design scheme of apple orchard intelligent monitoring system based IOT, and taking the modules of dynamic monitoring, farming suggestion, planting decision making, and information push in the system as examples, it explains the specific methods of applying IOT to the realization of apple orchard monitoring management in detail. This apple orchard intelligent monitoring system provides not only detailed monitoring data of apple growth for vegetable and fruit agricultural cooperatives, but also decision making support for farming. The research of the system will be helpful in promoting the extension and application of IOT technology in agricultural production.
Improving estimation efficiency in quantile regression with longitudinal data

Abstract In this paper, we consider two weighted estimators to improve estimation efficiency in quantile regression with longitudinal data. The first estimator is from weighted quantile regression, and the second estimator is from weighted composite quantile regression, where the weights in the second estimator are from the first estimator. Different from earlier literature, our weights are quantile adaptive, which borrow information from the intra-subject correlation of the conditional quantile scores, rather than the conditional least squares scores. The weight for each subject is obtained from smoothed empirical likelihood quantile estimator, where quadratic inference function method is used to model the inverse of the correlation matrix of the conditional quantile scores. Under some regularity conditions, we prove that the weighted estimators are more efficient than the standard quantile regression estimators with equal weights. We conduct a simulation study and a real data analysis to evaluate the performance of the proposed approach.
Supply Chain Management in the Aquaculture Industry: The Case of Food Fish Aquaculture in Sri Lanka

The study was taken up with the objective of identification of local and regional market potential for each main food fish species commonly found in the catch of inland fisheries and aquaculture in Sri Lanka and to identify the market segmentation of each of these fish species and prices in local and regional markets. The study methodology included both desk research and primary research in landing sites and regional markets of Western, Eastern, Sabaragamuwa and North-Central provinces in Sri Lanka. The study has employed BCG matrix for interpretation and analysis the supply chain. The study identifies the different value chains present in the trade map. Fishery value chain is dominated by few big players and a number of intermediaries were high and hence adds up to the cost of product without adding value to the chain. Presence of &ldquo;patron-client relationship&rdquo; throughout the supply chain is prevalent. The research indicates that the demand for fishe in the regional markets is dominated mainly by few preferential species. <strong>Key words: </strong>supply chain; fish and fishery products; Sri Lanka &nbsp; DOI: <a href="http://dx.doi.org/10.4038/suslj.v9i1.3741">http://dx.doi.org/10.4038/suslj.v9i1.3741</a> &nbsp; <em>Sabaramuwa</em><em> University</em><em> Journal</em>, Volume 9 Number 1; December 2010, pp 147-169
Molecular structure and cell cycle regulated assembly of the kinetochore

Accurate chromosome segregation in eukaryotes requires the assembly of the macromolecular kinetochore complex at centromeres to attach chromosomes to the mitotic spindle. The kinetochore proteins are organized in stable subcomplexes that bind to dynamic microtubules and ensure fidelity of sister chromatid separation through feedback control. Characterizing the kinetochore structure will significantly advance our understanding of chromosome segregation and how defects in this process can lead to aneuploidy, which is associated with tumorigenesis. X-ray crystallography has provided detailed insights into the function of subcomplexes, however, a molecular analysis of the native kinetochore subunit architecture is still missing. I have recently combined chemical cross-linking with mass spectrometry (CXMS) which allows for the first time the topological analysis of native macromolecular protein structures by a comprehensive set of distance restraints. Applying this approach to kinetochores assembled on budding yeast minichromosomes I aim to elucidate the architecture of the native centromere-assembled kinetochore complex and analyze how tension sensing by the chromosomal passenger complex is integrated into the structure. Secondly, the systematic analyses of changes in phosphorylation levels and in protein stoichiometries of soluble and nucleosome-associated human kinetochore complexes will reveal how the tight temporal control of assembling a functional kinetochore in mitosis is achieved. Thirdly, I will investigate the architecture of the centromere-associated network of kinetochore proteins by CXMS to unveil its role in directing CENP-A replenishment at mitotic exit in order to maintain centromere identity through generations. The analysis of the native kinetochore structure in different functional states will provide fundamental mechanistic insights and help us to understand how this architecture confers fidelity to centromere propagation and chromosome segregation.
Modelling Freight Transport

Freight Transport Modelling is a unique new reference book that provides insight into the state-of-the-art of freight modelling. Focusing on models used to support public transport policy analysis, Freight Transport Modelling systematically introduces the latest freight transport modelling approaches and describes the main methods and techniques used to arrive at operational models. As freight transport has grown exponentially in recent decades, policymakers now need to include freight flows in quantitative evaluations of transport systems. Whereas early freight modelling practice was inspired by passenger transport models, by now it has developed its separate stream of methods and techniques inspired by disciplines such as economic geography and supply chain management. Besides summarizing the latest achievements in fundamental research, this book describes the state of practice and advises practitioners on how to cope with typical challenges such as limitations in data availability
Digital Content Rendering that Supports Alpha Is Shape (AIS) as part of Knockout Groups

Digital content rendering techniques are described that support Alpha Is Shape (AIS) as part of a knockout group. In order to support AIS rendering of an object within a knockout group, an alpha-separated color value is generated by removing an effect of an alpha value of an object of a knockout group on a pixel. A color-blended color value is then generated by the GPU based on the alpha-separated color value and a color value associated with a backdrop of the knockout group for the pixel. A determination is also made as to an amount of spatial coverage for the pixel by comparing the object to the pixel. From this, a rendering color value is generated by the GPU based on the color-blended color value, the alpha value, and the amount of spatial coverage of the pixel by the object.
Towards an ecosystem approach to aquaculture: Assessment of sustainable shellfish cultivation at different scales of space, time and complexity

article i nfo The need for an ecosystem approach to aquaculture has led to the development of several aquaculture analysis tools in recent years, working at different scales of space (farm- to system-level), time (seasonal to annual and/or long-term analysis) and complexity (ease of use to complex process-based modelling). This work has tested the application of a range of complementary tools to the analysis of aquaculture practices and ecosystem impacts in Killary Harbour, Ireland. The selected tools included a system-scale, process based ecological model (EcoWin2000), a local-scale carrying capacity and environmental effects model (FARM) and a management- level eutrophication screening model (ASSETS). Both the system-scale and farm-scale models used ShellSIM to simulate individual shellfish growth. The tools were used to analyse the relationship between shellfish productivity and food sources, theimpacts of changes to stocking densities of shellfish, and an overall assessment of the ecological status of Killary Harbour. EcoWin2000 was able to support a complex analysis, but required a significant amount of input data and effort for calibration and result analysis. FARM was able to provide similar (although less detailed) results at the shellfish farm scale with a smaller effort for parameterization and application, but was limited to testing scenarios with relatively moderate changes to present-day conditions. ASSETS provided simple, management-level results with a relatively low level of input data, although it is not appropriate for complex analysis. This paper illustrates the complementary nature of these tools, and how the
Multimat.: Entwicklung von Mehrprozess-Multimaterial-Automobilkomponenten

Das ultimative Ziel des Multimat-Projekts ist es, ein innovatives Referenzprodukt für die Automobilindustrie mit der Integration leichterer Materialien natürlicher Herkunft und der in die Form integrierten Produktionsprozesse der Einspritzung und Montage unter Berücksichtigung des gesamten Lebenszyklus des Produkts zu schaffen.
Towards a paleotsunami chronology in the southern aegean and levantine seas, eastern mediterranean

In 2004 and 2011, the World witnessed the devastating consequences of Sumatra (Indonesia) and Tohoku (Japan) tsunamis. We realized once again how seriously tsunamis can threaten our lives and infrastructures, and how vital tsunami hazard assessment studies are to reveal especially the recurrence of tsunamis by means of paleotsunami investigations. In the Aegean and the Levantine seas (Eastern Mediterranean), although the historical records report 17 damaging tsunamis during the last 2500 years, the geological records of the paleotsunamis revealed so far in the region are far from providing information useful for reliable tsunami hazard assessments. The proposed research action aims to take a significant step forward towards constructing paleotsunami chronologies in the eastern Mediterranean by investigating the sedimentary sequences of six lagoonal sites located along the south-western and southern coasts of Turkey. The methods for the proposed research comprise piston coring the sequences, high-resolution micro-XRF core scanning, u-channel X-ray radiography, grain-size distribution analysis, and AMS 14C dating. In addition to revealing paleotsunami records in the region, the proposed research will bring new insights on detection of tsunami deposit in sedimentary sequences. Among the methods to be applied, high-resolution micro-XRF core scanning have been utilised in only a few studies before, while u-channel X-ray radiography has never been used in any paleotsunami investigation. Hence, the proposed research will mediate a significant transfer of the knowledge gained in paleolimnology/paleoclimatology/paleoceanography disciplines to paleotsunami research. Another important part of the project will be the organization of stakeholders’ meetings in the important cities of the study area in order to inform people about the scope and the results of the research and to increase the public awareness about tsunamis.
First report of genotype #65 of Toxoplasma gondii in pigs

The aim of the present study was to isolate and genotype Toxoplasma gondii from pigs slaughtered for human consumption in northeastern Brazil. Indirect immunofluorescence antibody test (IFAT) was used to screen positive pigs. Tissues samples of animals with antibody titers ≥64 were submitted to bioassay in mice. One isolate of T. gondii was obtained, and the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique, using 11 markers (SAG1, SAG2, altSAG2, SAG3, BTUB, GRA6, c228, c292, L358, PK1, and APICO), was applied to evaluate the genetic variability. DNA from reference strains was used as a positive control. By means of genetic analysis, genotype ToxoDB #65 was identified, which is considered an atypical strain. This is the first record of genotype #65 in pigs. Thus, further studies in this region are necessary to determine the genetic variability of T. gondii in pigs and possible impact on public health.
FOLDBACK FREE CAPACITANCE-TO-DIGITAL MODULATOR

A capacitance-to-digital (CD) modulator converts capacitance of a differential pressure sensor to a pulse code modulation output signal. The first stage of the CD modulator is a sigma-delta integrator having an auto-zero capacitor connected between an integrator input node and an amplifier input. During an auto-zero phase, a feedback capacitor is connected between the amplifier input and output, and the auto-zero capacitor stores a voltage that is a function of leakage resistance of the sensor capacitor connected to the integrator input node. During an integration phase, the feedback capacitor is connected to the integrator input node. If an overpressure/short circuit condition exists, the stored voltage on the auto-zero capacitor induces a current to flow to the feedback capacitor to drive the integrator to saturation and suppress foldback anomaly.
Memórias coloniais: Alemanha e Camarões

Gouaffo, Albert; Stefanie Michels (Hrsg.): Koloniale Verbindungen – transkulturelle Erinnerungstopografien. Das Rheinland in Deutschland und das Grasland Kameruns. Bielefeld 2019: ISBN 978-3-8376-4529-3
Valorisation of the common Identity around the Stone

The project intends to stimulate the artistic creativity on “the stone”. Among the project’s expected outputs are: • A Multilingual comparative study on architecture; • A photographic selection of architectural stone works. • A multilingual catalogue of cultural and tourist itineraries along the “Routes of Stone”. • Promotion of the “Routes of Stone” in 2 international tourism exhibitions. • A Competition for the selection of unpublished audiovisual material; and 2 short films to be selected. • A Competition for the selection of artistic craftsmanship stone works • A photo catalogue of artistic stone craftsmanship and • A collection of artistic craftsmanship stone works to be displayed in the exhibitions. • Stone itinerant exhibitions