SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
From typhoid fever to antimicrobial mechanisms

This programme will identify critical host mechanisms that kill bacterial pathogens by exploring a novel mammalian antimicrobial pathway, which I discovered.  This pathway protects non-susceptible hosts from typhoid fever.  Typhoid fever is caused by Salmonella Typhi, a unique intracellular pathogen that kills more than 200,000 humans per year.  Yet, Salmonella Typhi does not infect other mammalian species, such as mice.  An understanding of the mechanisms that protect mice from Salmonella Typhi infection will enable me to determine how Salmonella Typhi circumvents these protective mechanisms in humans to cause fatal disease.  I have demonstrated that the mechanisms protecting mice are based on an intracellular trafficking process regulated by the Rab32 GTPase.  The following critical questions will be addressed:

1) What killing molecules does the Rab32-dependent trafficking pathway deliver to the Salmonella Typhi vacuole?
2) How is the Rab32-dependent trafficking pathway regulated?
3) Is the Rab32-dependent trafficking pathway active in human macrophages?  And if so, how does Salmonella Typhi evade killing to replicate in human macrophages?

I will define the antimicrobial mechanisms responsible for killing Salmonella Typhi and other bacterial pathogens by exploiting a powerful combination of functional genomics, cutting-edge “omic” approaches and versatile screens.  This ambitious, high-gain programme will:

I) Identify novel antimicrobial molecules that kill bacterial pathogens;
II) Identify critical regulators of this novel antimicrobial pathway;
III) Elucidate how Salmonella Typhi establishes deadly infections in humans and identify new therapeutic targets.

The overall objective of this programme is to improve global health by capitalising on novel mechanisms of host defence that will not only elucidate ways to treat typhoid, but also extend these insights to the treatment of other bacterial diseases.
SINGLE-LENS EXTENDED DEPTH-OF-FIELD IMAGING SYSTEMS

An extended depth of field (EDOF) imaging system (10) is disclosed that has a corresponding extended depth of focus (EDOF'). The imaging system has an optical system (20) consisting of a single lens element (22) and an objectwise aperture stop (AS) arrange substantially at a zero-coma axial position. The single lens element is configured so that the optical system has a select amount of spherical aberration (SA) in the range 0.2? =SA = 2?, where ? is an imaging wavelength. The imaging system has an image sensor (30) for forming a digitized raw image (IM) of an object (OB). In applications, the raw image can be used directly. The imaging system also has an image processing unit (54) adapted to process the raw images to form contrast-enhanced images. The image processing includes forming an enhanced modulation transfer functions (MTF) using a gain function (G) applied to the "raw" MTF. Embodiments of the single lens element include at least one diffractive feature (23) to reduce chromatic aberration. Single lens elements with at least one aspheric surface (S1, S2 or S1 and S2) are also disclosed.
Fueling Hope: Stem Cells in Social Media

Social media is broadening opportunities to engage in discussions about biomedical advances such as stem cell research. However, little is known about how information pertaining to stem cells is disseminated on platforms such as Twitter. To fill this gap, we conducted a content analysis of tweets containing (i) a stem cell keyword, and (ii) a keyword related to either spinal cord injury (SCI) or Parkinson disease (PD). We found that the discussion about stem cells and SCI or PD revolves around different aspects of the research process. We also found that the tone of most tweets about stem cells is either positive or neutral. The findings contribute new knowledge about Twitter as a connecting platform for many voices and as a key tool for the dissemination of information about stem cells and disorders of the central nervous system.
High load gear and bearings materials

The Ultra High Bypass Ratio technology achieved with the geared turbofan concept, that decouples fan and turbine speeds by means of an Integral Drive System (IDS), is an innovative architecture that can enable significant reduction in fuel burn, noise and emissions.

The HILOGEAR (High load gear and bearings materials) project supports the aims to mature differentiating technologies and processes that could be introduced in the innovatve drive system module for the UHPE (Ultra High Propulsion Efficiency Engine) demonstrator. 

Since classical aerospace materials, although performant, do not exhibit all the necessary technical characteristics to fulfil both bearing and gears strength needs for their application in the UHPE power gearbox, innovative materials and heat treatments have to be investigated.

Therefore the main HILOGEAR project tasks and goals will be:
•	the selection, jointly with the TM, of promising materials and surface treatments suitable both for gears and bearings
•	testing activities on bearings also in contaminated conditions
•	testing activities on gears in high load and high temperature conditions similar to those of new engines. 

The activity will be managed with a Phase & Gate approach and will include detailed technical / program, documentation, including planning, drawings, design report, risk analysis, test plan and test requirements, test results and test analysis reports.
STUDIOBERTI DI Granata & VILLA SOCIETÀ EM ACOMANDITA SEMPLICE

PREPARAÇÃO DE PAREDES E PORTÕES (PORTA E JANELA) COM OBRAS DE ALVENARIA NO ARQUIVO LOCAL/ARMAZENAMENTO COLOCADO NO PAVIMENTO INFERIOR DA PROPRIEDADE EM GÉNOVA CORSO TORINO 14. PORTA DE DESMONTAGEM E JANELA DE MADEIRA, INSTALAÇÃO N.2 CONTRAQUADROS EM ALUMÍNIO TUBULAR 20X40 (A SER MURADO) INSTALAÇÃO N.1 PORTA DE ALUMÍNIO ALCOA SÉRIE R40 CINZA PINTADO GRINZ COM BLOQUEIO 3 PONTOS DE FECHAMENTO E ALÇA INT/EST E VEDAÇÃO DE PERÍMETRO DUPLO. INSTALAÇÃO N.1 JANELA 1 PORTA DE ALUMÍNIO ALCOA SÉRIE R40 CINZA PINTADO GRINZ VIDROS ANTIQUEBRAMENTO 4+4 E JUNTA DE PERÍMETRO DUPLO. ALVENARIA TRABALHA PARA PREPARAR, APOIAR E TERMINAR AS INSTALAÇÕES PARA INSTALAÇÃO POERA E JANELA CONTRA INUNDAÇÕES, NOVO SISTEMA ELÉTRICO CONTRA INUNDAÇÕES. FORNECIMENTO E INSTALAÇÃO DE BOMBA SUBMERSÍVEL À PROVA DE INUNDAÇÃO EQUIPADA COM FLUTUADOR PARA ATIVAÇÃO AUTOMÁTICA.
Patrocínio por empresas de alimentos e bebidas no futebol: análise da Copa América 2019

To identify the sponsorship by food and beverage companies of the teams participating in the 2019 Copa América Soccer Cup and associate this sponsorship with characteristics of the teams and their respective countries.The sponsors of the 10 teams participating in the 46th edition of the Copa América were identified. These entities were classified into (i) food companies, (ii) alcoholic beverage companies, and (iii) other segments. The food companies were classified according to their products, according to the NOVA classification. In addition, data on the number of titles previously won by the teams in the Copa America and the World Cup were obtained, as well as data on the countries' Human Development Index, annual per capita sales of ultra-processed foods, and annual per capita consumption of alcoholic beverages.A total of 89 sponsorships were identified for the 10 teams studied, some of these supporting two or more teams. Eighteen percent of the sponsors were food companies, with 12.4% being ultra-processed foods. The alcoholic beverage category represented 7.9% of the sponsors. Ultra-processed beverage and alcoholic beverage companies sponsored seven of the 10 teams studied. We noted higher participation of ultra-processed foods company sponsors in teams from countries with higher Human Development Index, sales of ultra-processed foods, and number of Copa América and World Cup titles. The sponsorship by alcoholic beverage companies was higher for teams from countries with lower Human Development Index, alcohol consumption, and number of Copa América and World Cup titles.A significant presence of ultra-processed food and alcoholic beverage companies as sponsors of South American soccer teams was noted, along with the fact that sport performance characteristics of the teams and socioeconomic and market issues of the countries are associated with the occurrence of sponsorship.
Lock for automobile safety belt.

In a lock for safety-belt systems in vehicles which are equipped with tautening devices engaging on the lock, an automatic opening is prevented by a two-armed lever (42) which is mounted pivotably on the load-bearing housing (10). During each actuation of the release button (32), the lever is pivoted out of its position of rest into a deflected position. At the end of a tautening movement, one (44) of the arms of the lever (42) projects into the path of movement of the release button (32), in order to prevent its further movement in the actuating direction. <IMAGE>
Performance of combined tillage tool operating under four different linkage configurations

Abstract Since tillage is one of the processes requiring high power, energy consumption in field operations is of great concern to farmers and researchers. A combined tillage tool has been recognized as one measure to reduce the power requirements in field preparation. In this research work, a combined tillage tool consisting of a subsoiler and rotary harrow (joined using four different linkage configurations) were tested under actual field conditions. The test parameters consisted of: tillage tools (combined tillage tool with four different linkages, a sole subsoiler and a sole rotary harrow), forward speeds (1.79, 2.67, and 3.33 km h−1), and rotational speeds of the rotor (299 and 526 rpm). The experiment site was located at 14.00 °S and 99.58 °E having a clay soil type and bulk density in the range 1.5–1.7 g cm-3 with an average water content of 16.6% (db). The results indicated that the combined tillage tool was able to reduce the draft for subsoiling by 4.4–11.3% depending on the linkage configuration compared with the same sole subsoiler used alone. There were significant effects of the rotational speed of the rotary harrow and the forward speed on the drawbar power, the PTO power, and the total power. The combined tillage tool with linkage IV consumed the least total power. The combined tillage tool with linkages I to IV used less total power by 13.7, 12.2, 10.5, and 15.3%, respectively, compared with the combined power required by the sole subsoiler and sole rotary harrow working separately.
The Life-Saving Effectiveness of Body Armor for Police Officers

The objective of this study was to determine the effect of protective body armor on a police officer's risk of being killed and estimate the benefits and costs of outfitting police with body armor. In the United States, for police shot in the torso from 2004 to 2007 (n = 262), we calculate the relative risk of death from a gunshot without and with body armor. We estimate the benefit of body armor using the willingness-to-pay approach and compare it with the cost of supplying armor to police not currently wearing armor. The results show that the relative risk of dying without armor is = 3.4 (95% CI: 2.4 to 4.6). Outfitting all police with armor would save at least 8.5 lives per year, resulting in a benefit that is nearly twice the cost, or a net benefit of approximately $100/officer. Body armor more than triples the likelihood that a police officer will survive a shooting to the torso. Outfitting all police with armor yields a positive net benefit and is strongly justified economically.
Gravitational lensing analysis for data intensive upcoming surveys

Gravitational lensing is one of the major tools to address the long-standing problems in astrophysics and cosmology, such as dark energy, dark matter, and black hole physics. Progress has so far been limited by the small number of known lensed systems and the intricate nature of the phenomenon, requiring painstaking handcrafted modelling approaches, hard-to-procure high-quality data, and lengthy computations. Upcoming all-sky surveys will revolutionize the field by discovering orders-of-magnitude more lenses and providing adequate information to understand them in depth. Mining these massive troves of data for the new astrophysical discoveries they hold requires a paradigm shift in our analysis approaches, providing high flexibility, automation, and adaptability to a much larger parameter space, in order to determine critical lensing and physical parameters. GLADIUS has the potential to spearhead gravitational lensing science with the next generation of observations by: i) increasing the accuracy and flexibility of the time delay method to measure cosmic expansion ii) disentangling baryonic and dark matter in galaxies through lensing self-consistently and iii) providing accurate predictions of those rare microlensing events, rich in information on quasar structure and black hole environments. To this end, existing state-of-the-art traditional modelling approaches and simulations will be fused with the groundbreaking machine learning framework of Deep Learning and extended through powerful methodologies, like supervised and generative learning, dramatically increasing the scope of gravitational lensing studies. The resulting data-intensive framework will be directly applicable to the high-resolution imaging and monitoring data products of the upcoming Euclid and LSST surveys. GLADIUS is perfectly aligned with the MSCA scope, allowing me to combine my lens modelling expertise with the leading role of EPFL in major global observational and modelling projects.
The BMW Story: Production and Racing Motorcycles from 1923 to the Present Day

Background history to the company founded in 1917 to produce aircraft engines The first 500cc boxer twin, the R32, of the 1920s, and the first racing machine, the R37 The difficult 1930s, culminating in the R75 that became the German army's most popular motorcycle during World War II The often-overlooked single-cylinder machines, which remained in production from 1925 to 1966 The post-war resurrections, including the RS54 racers and side-car Grand Prix racing The R75/5, which heralded a new generation of boxer twin lasting until the early 1990s The K-series, and the new R1100RS boxer launched in 1993 Appendices of technical specifications for all BMW motorcycles.
Enhancing SME growth by the integration of Artists in ICT projects

During the last decade, there has been an increasing recognition of the importance of artistic and creative processes as catalysers of innovation, something particularly noted in Information and Communication Technologies (ICT) that intersect in many fields with artistic processes. However, as stressed by the Digital Agenda for Europe, Europe continues to “under-use the creativity of SMEs”. To tackle this, in 2016 the EC launched ‘STARTS’ initiative (Science, Technology and the ARTS) under Horizon 2020.

RegionArts partners are convinced of the need of integrating arts in ITC for SME innovation and competitiveness. As regional authorities, business development agencies and creative clusters, they have been working on promoting these cross-overs for the last years. But it is not an easy task. Most policies available are conceived for an information and knowledge age (even for an industrial age) that is no longer predominant. Support offer is still fragmented. Public support programmes are too rigid and there is a lack for occasions for collaboration and outreach. There is also a need for a common language: existing initiatives often start from creative sector and reach out to ICT, or vice versa, i.e. both parties are not involved as equal partners.

Our objective is to improve the implementation of Structural Funds/other funds in partner regions, through adapting or designing 1 support scheme in each region for the promotion of collaborations between artists and ICT companies. Consequently, through the improved support scheme, we will promote around 140 new collaborations in total (around 20 per region), 20% of the beneficiary SMEs introducing an innovation by 2022.

Our main outputs will be:
- 7 thematic workshops and 7 study visits
- 3 policy booklets for governments on steps to build support programme
- 7 regional match-making events ‘ICT meet the arts’
- 7 Design Action Plans
- 1 high-level conference in collaboration with SERN (Start-Up Europe Regions Network)
Intelligent Collision Avoidance Decision for Single Ship Considering Ship Maneuverability

Aiming at the collision avoidance problem of large ships at sea, this paper studies a collision avoidance method that can take into account the difficulty of steering of large ships and the large inertia of motion. According to the KT equation of the ship, its kinematic model is established, and the ship hazard model is established on the basis of fully considering the maneuverability of the ship. The geometrical collision avoidance method is used to quantitatively calculate the ship's speed reduction range or steering range, and the decision is given in conjunction with COLREGS (Convention on the International Regulations for Preventing Collisions at Sea). The experimental results show that this method can solve the collision avoidance problem of large ships in open water area and has high accuracy and reliability.
The first blood test for the early detection and prognosis of acute myeloid leukaemia

Acute myeloid leukaemia (AML) accounts for about 25% of all leukaemia in the Western world. Its overall survival rate for 5 years is the lowest of all types of leukaemia (27%): above 60% of AML patients will succumb to the disease.  Currently, there is no method for early detection of AML. It is diagnosed based on the presence of blasts in bone marrow samples and must be treated immediately to avoid a near-future death. Due to this late detection, AML treatment is of low effectiveness. 

The aggressive and often fatal nature of AML makes it a priority for developing early and fast diagnostic and prognostic tools.  We have identified a new biomarker for the early detection and prognosis of AML. This biomarker is detected and quantified by our innovative In vitro Diagnostic Test (IVD), named Serostrat, via a fast, cheap and routinely clinical blood analysis. We own the exclusive exploitation rights of SeroStrat. SeroStrat specifically targets the AML biomarker in blood cells, discriminates between AML unfavourable risk patients and AML patients with intermediate risks; is low-invasive and painfulness (only requires a blood sample instead of bone marrow samples); is fast and non-expensive (it can be used routinely in clinics in blood samples analysis by Flow cytometry) and will permit risk groups (persons aged >65), AML new patients, and persons in remission to be monitored easily and accurately for signs of recurrence.  

We are Leukos Biotech S.L. (Leukos), a Spanish spin-off company founded in 2015 from the prestigious Josep Carreras Leukaemia Research Institute.  Our goal is to enter fully into the biopharma sector, which will allow us to move to a business model which will create 50 new jobs and cumulative profits about € 22M by 2024.
Effects of low-pass filtering on intelligibility of periodically interrupted speech

The combined effect of low-pass filtering (cut-off frequencies between 500 and 3000 Hz) and periodic interruptions (1.5 and 10 Hz) on speech intelligibility was investigated. When combined, intelligibility was lower than each manipulation alone, even in some conditions where there was no effect from a single manipulation (such as the fast interruption rate of 10 Hz). By using young normal-hearing listeners, potential suprathreshold deficits and aging effects that may occur due to hearing impairment were eliminated. Thus, the results imply that reduced audibility of high-frequency speech components may partially explain the reduced intelligibility of interrupted speech in hearing impaired persons.
Becoming muslim: cultural change, everyday life and state formation in early islamic north africa (600-1000)

The Muslim conquests of North Africa in the 7th century transformed the everyday lives of communities– between 800-1000, the region experienced an economic ‘Golden Age’, visible in the growth of urban populations, intensified exchange across a vast trading system and the introduction of new agricultural practices and technologies. New social-religious norms underpinned the development of a distinctly ‘Islamic cultural package’ marked by the spread of new aesthetics, public and private architecture and Muslim dietary practices. Despite significant recent advances, much of our knowledge continues to reflect the experience of rulers and elites, rather than the bulk of the population. Our understanding of the timing and process of these innovations is hampered by a reliance on later literary sources, monumental architecture and the high arts, the absence of high-resolution archaeological data and an incomplete understanding of what these changes meant for the people living on the ground. Through new excavations and scientific analysis using state-of the-art methods, legacy datasets and written sources, this project will explore the underlying reasons for the spread of Islamic way of life in North Africa between ca. 600-1000 CE. In so doing, this project aims to make a paradigmatic shift in scholarly understanding of the impact of Muslim rule by focusing on local populations, their houses and their everyday practices. It will take a comparative approach and study long-term changes in housing, agriculture, diet and technology in three key regions: 1) the central Medjerda valley in Tunisia, the famed granary of Roman and Islamic Africa; 2) the fertile Sebou Basin in Morocco, at the centre of the Idrisid state; 3)  the Saharan oasis belt of the Wadi Draa in Morocco, on the margins of settled life. The ambitious objective is to rewrite the history of Muslim rule and the Islamisation of daily life from the perspective of the communities living through this pivotal period.
Competitiveness, Productivity, and Growth

African economies face two challenges in the future: weathering possible downturns in demand and prices of commodities; and creating a large number of jobs for the continent’s booming working-age population. High global demand for the continent’s natural resources, macroeconomic reform, foreign aid inflows, and concessional debt relief have helped African economies grow and ride out the financial crisis, but growth remains vulnerable. To continue to develop, African economies need to turn to high-productivity, job-intensive activities such as agro-processing, manufacturing, and services. Exports need to increase, and the private sector needs to be stimulated by, among other things, curbing anti-competitive behavior, improving infrastructure and financial services, and reducing the burden of regulatory requirements. Investing in education, technology, innovation, and entrepreneurship is key to realizing gains in productivity and competitiveness.
Opening sphere uab-cei to postdoctoral fellows

Presented by the Universitat Autònoma de Barcelona (UAB) as beneficiary, the project is part of a broader initiative named Sphere UAB-Campus of International Excellence (Sphere UAB-CIE) which aims at establishing a future pole for innovation by enhancing the integration of the R&D&I centres settled in the UAB campus and its surrounding. Seven partner institutions, members of Sphere UAB-CIE will be contributing to the co-financing and hiring fellows. Additionally other institutions will participate in the training and secondment activities.

The programme P-SPHERE programme will offer 3 years fellowships to a total of 48 fellows which will have the opportunity to develop their researcher’s careers in an exceptional environment. 
The P-SPHERE programme is articulated around five multidisciplinary research domains, including transversal technologies: Food, Health, Smart and Sustainable Cities, Cultural Heritage and Materials & Energy.
This fellowship programme is expected to contribute to realising the full potential of the recruited researchers and to add significantly to the development of their careers in the academic and non-academic sectors.