SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Worst-case total dose radiation effect in deep-submicron SRAM circuits

The worst-case radiation effect in deep-submicron SRAM (static random access memory) circuits is studied through theoretical analysis and experimental validation. Detailed analysis about the radiation effect in different parts of circuitry is presented. For SRAM cells and a sense amplifier which includes flip-flop structures, their failure level against ionizing radiation will have a connection with the storage state during irradiation. They are inclined to store or read the same state as the one stored during irradiation. Worst-case test scheme for an SRAM circuit is presented, which contains a write operation that changes the storage states into the opposite ones after irradiation and then a read operation with opposite storage states. An irradiation experiment is designed for one 0.25 μm SRAM circuit which has a capacity of 1 k × 8 bits. The failure level against ionizing radiation concluded from this test scheme (150 krad(Si)) is much lower than the one from the simplest test scheme (1 Mrad(Si)). It is obvious that the failure level will be overestimated if the simplest test scheme is chosen as the test standard for SRAM circuits against ionizing radiation.
Insulync: changing the way diabetes is treated

Medilync is a start-up based in Iceland and founded in 2012 with the goal of revolutionizing the management and treatment of diabetes. Medilync has created a medical device that simplifies the way patients manage glucose measurement and insulin delivery. Diabetes requires a highly-disciplined routine of glucose control and insulin injections, being lack of accuracy and of recordkeeping one of the main reasons for a deteriorating health. There are about 60 million people with diabetes in the EU and this number will rise to 71 million by 2040. Up to 75% of all people with diabetes are not in good control of their condition, leading to huge social and economic costs. 40% of diabetes patients are >65 years, and need to involve family members, friends and providers in real-time to improve adherence to treatment. Medilync brings the first all-in-one medical device, INSULYNC, which allows for easy blood glucose measuring, recording of the injection of insulin, and real-time delivery of all this information for storage on a cloud computing system, Cloudlync, sharing it with the doctor and the patient’s family. INSULYNC and Cloudlync are highly integrated to help the patient keep track of medication and to organize all data relative to diabetes management under one single system. The solution helps patients to engage with family and doctors (improves treatment adherence by 35%), with the result of patients spending less (could save around €40 billion a year to European healthcare systems) and being in better health. The overall objectives of this project include finalizing and validating INSULYNC and Cloudlync with key stakeholders (e.g. clinical trials in key target markets), and preparing our entry strategy into the European market. Through this project we aim to boost the growth of our company and obtain €14.17M revenues (overall profit of 55%), while creating 30 new jobs by 2025, with a ROI of €4.9 per euro invested.
The cybernetic lower-limb cognitive ortho-prosthesis plus plus

The global goal of the CYBERLEGs Plus Plus project is to validate the technical and economic viability of the powered robotic ortho-prosthesis developed within the framework of the FP7-ICT-CYBERLEGs project as a means to enhance/restore the mobility of transfemoral amputees and to enable them to perform locomotion tasks such as ground-level walking, walking up and down slopes, climbing/descending stairs, standing up, sitting down and turning in scenarios of real life. Restored mobility will allow amputees to perform physical activity thus counteracting physical decline and improving the overall health status and quality of life.
This consortium will pursue the achievement of the global goal by addressing four specific innovation objectives. 1) Further developments of the existing CYBERLEGs hardware modules, namely the 2-degree-of-freedom active transfemoral prosthesis, the active wearable orthotic device, and the wearable sensory apparatus. 2) Further developments of the existing multi-layered CYBERLEGs control system, to enhance its reliable use in real-life scenarios. 3) Carrying out two multi-centre clinical studies, that validate the therapeutic potentialities and the economic viability of a robotic ortho-prosthesis which restores the amputees’ locomotion abilities in scenarios of activities of daily living. 4) Implementation of a 3-phase strategy to foster the start of the market exploitation within the time frame of the CLs++ project.
This proposal focuses on the demonstration in an operational environment (TRL=7) from both the technical and economic viability view point of a modular robotics technology for healthcare, with the ultimate goal of fostering its market exploitation. The proposals involve players from academia, end users, as well as robotics and healthcare industry. Therefore this proposal fits the specific challenge of the scope c of the call H2020-ICT-25-2016-2017.
Combined fluidized bed retorting and circulating fluidized bed combustion system of oil shale: 2. Energy and economic analysis

Abstract Retorting oil shale can produce shale oil, semicoke, water and fuel gases. Shale oil can be used as an important substitute oil supply, and semicoke and fuel gases may be burnt as fuels. An interesting issue is about how to utilize and distribute the heat from the combustion of semicoke and fuel gases, not only providing enough heat for retorting oil shale, but also producing more available energy products and less energy losses. Based on a combined system of oil shale FB (fluidized bed) retort and semicoke CFB (circulating fluidized bed) boiler, a comprehensive process flow was developed and an optimization calculation was conducted to achieve mass and energy balances of the whole system. Simulation indicated that, burning semicoke and fuel gases from retorting Huadian oil shale at the retorting temperature of 490 °C could not only provide enough energy required for the endothermic oil shale drying and retorting processes, but also supply extra energy for power generation or heat supply. The sensitivity of various operating parameters on the performance of the process was also discussed to optimize the comprehensive utilization system of oil shale. This work provided a reference for developing the new comprehensive utilization technology of oil shale.
Epigenetic fine-tuning of t cells for improved adoptive cell therapy

Adoptive T cell therapy is a promising approach in various clinical settings, from target-specific immune reconstitution fighting cancer and chronic infections to combating undesired immune reactivity during auto-immunity and after organ transplantation.
However, its clinical application is currently hampered by: 1) the acquisition of senescence during the required in vitro expansion phase of T cells which limits their survival and fitness after infusion into the patient, and 2) the functional plasticity of T cells, which is sensitive to the inflammatory environment they encounter after transfusion and which might result in a functional switch from the desired effect (e.g. immunosuppressive) to the opposite one (pro-inflammatory). 
I want to tackle these obstacles from a new molecular angle, utilizing the profound impact of epigenetic mechanisms on the senescence process as well as on the functional imprinting of T lymphocytes. Epigenetic players such as DNA methylation essentially contribute to T cell differentiation and harbor the unique prospect to imprint a stable developmental and functional state in the genomic structure of a cell, as we could recently show in our basic immune-epigenetic studies. Therefore, I here propose to equip T lymphocytes with the required properties for their successful and safe therapeutic application, including their functional fine-tuning according to the clinical need  by directed modifications of the epigenome 
('Epi-tuning').
To reach these goals I want: 1) to reveal strategies for the directed manipulation of the epigenetically-driven mechanism of cellular senescence and 2) to apply state-of-the-art CRISPR/Cas9-mediated epigenetic editing approaches for the imprinting of a desired functional state of therapeutic T cell products. These innovative epigenetic ""one-shot"" manipulations during the in vitro expansion phase should advance T cell therapy towards improved efficiency, stability as well as safety.
Wheels of fortune: the economic impacts of wheelchair provision in Ethiopia

Although approximately 1 billion people in the world live with physical disabilities, there is a lack of rigorous research on the economic impacts of providing assistive devices for persons with disabilities. This study involves 261 people with disabilities in Addis Ababa, Ethiopia, where 121 had received wheelchair donations through nonprofit organisations. Using covariate matching (CVM), seemingly unrelated regressions (SUR) and a series of robustness checks for endogeneity, it is found that those given access to a wheelchair devoted 1.75 more hours per day to work, 1.40 fewer hours per day to street begging and realised a 77.5 per cent increase in income. Results point to a 122 per cent internal rate of return based on new income created from wheelchair donation.
Exploration of safety, tolerability and clinical efficacy of solnatide imp in patients infected with the 2019 new coronavirus

Clinical features of patients infected with the 2019-nCoV have revealed that these patients suffer from severe respiratory failure, and presence of a life-threatening pulmonary oedema (PPO). Approx. 30% of 2019-nCoV-patients further develop life-threatening Acute Respiratory Distress Syndrome (ARDS). Mortality rate of these patients is very high.
Initiator and Scientific Coordinator of the project, APEPTICO, is a SME biotechnology company (EMEA/SME/012/09) developing peptide-based products targeting life-threatening pulmonary diseases, including oedematous respiratory failure, acute lung injury, primary graft dysfunction, high altitude pulmonary oedema and PHA type 1.
APEPTICO’s lead-compound Solnatide (INN) has been designed for the therapeutic treatment of patients with Acute Respiratory Distress Syndrome (ARDS) and various forms of life-threatening Pulmonary Oedema (PPO). Orally inhaled Solnatide has delivered clinical proof-of-concept in one Phase I, and in two Phase II clinical studies (EUDRACT No. 2011-000223-33, 2012-001863-64, 2013-000716-21).
Today, no medicine has been approved for the therapeutic treatment of Pulmonary Permeability Oedema and ARDS.
Currently, Solnatide is subject to a Phase IIB trial (EUDRACT No. 2017-003855-47) for the “treatment of pulmonary permeability oedema in patients with ARDS”. The Phase IIB clinical trial has been approved by the German and the Austrian Competent Authorities, as well by Ethic Committees of leading Medical University Hospitals in Germany as well Austria.
Most recently, APEPTICO has entered into a partnership with HAISCO Pharmaceutical Group in Chengdu, Sichuan, P.R. China. HAISCO has access to core areas and leading Medical University Hospitals in the P.R. China.
Accordingly, APEPTICO proposes to immediately apply the Solnatide IMP for the treatment of patients infected with the 2019-nCoV and to demonstrate safety, tolerability and clinical efficacy of Solnatide IMP in 2019-nCoV patients.
The overall project coordination and external communications is by RTDS Association (www.rtds-group.com/association)
Sharing researchers’ passion for evidences and resilience

The SHARPER goal is to make the researchers’ passions accessible and comprehensible to everybody, starting from young generations, through engaging communication formats and activities that take place in unusual venues and make the researchers’ life a shared experience with a large audience in Italy. Researchers are evidences hunters, their passion for facts, data and observations collected, accumulated and interpreted with a constant and patient day by day activity, is one of the researchers’ main features. It is usually combined with their ability and commitment to use these evidences to tackle some of the more complex issues that are relevant to all of us: from fundamental research problems such as those related to the origin of the Universe or the structure of our brain to technological endeavours and societal challenges. The constant quest for evidences reveals, not only their insatiable curiosity but also their passion for challenging the limits of our knowledge and innovate going beyond the known, being able to accept and adapt to the changes or, in a sentence, to show a profound passion for resilience. The combination of these researchers’ passions for identifying and understanding facts and for wisely adapt and evolve by innovating and the opportunity for citizens to meet them, seems to be vital in a constantly changing society.. The acronym SHARPER - Sharing Researchers’ Passion for Evidences and Resilience summarizes all these elements and is the name of the European Researchers’ Night in Italy that will take place on the 28th of September 2018 and on the 27th of September 2019 simultaneously in 11 cities: (North Italy) Trieste (hosting city of ESOF 2020) Pavia;  (Centre Italy) Ancona, Macerata, Perugia, L'Aquila; (South Italy) Napoli (Sicily) Palermo (Italian Capital of Culture 2018), Catania (Sardinia) Cagliari and Nuoro.
Adaptation of the activity to the new reality COVId 19

With this request, the company intends to obtain support in order to match its activity to the new economic reality and the new legal imperatives.
Adaptation of the Diving Center Expedition Dive Team to the new conditions resulting from COVID-19

The aim of the project is to adapt the Diving Centre Expedition Dive Team to the new COVID-19 conditions and to rebuild the demand for the Centre’s services, which collapsed as a result of the COVID-19 pandemic. The decrease in the number of customers was well over 80 % compared to the corresponding period of 2019. As a result, the current activity is highly deficient and the Centre’s functioning will be at risk with a longer period of time. The implementation of the project is aimed at ensuring the safety of customers in the face of the epidemiological threat and during diving in the water, increasing the attractiveness of existing services directed to recreational divers and creating a new offer for the professional divers segment. Investment activities related to the acquisition of new competences and marketing have been planned for the current year.
Influence of single centers in a multicenter trial on robot-assisted therapy?

Stroke is one of the leading causes of disability, and advances in neurorehabilitation bring new therapy forms that aim to enhance recovery after stroke. In a multicenter clinical trial, we tested whether robot-assisted therapy of the arm with the therapy robot ARMin is superior to conventional therapy with regard to improvement in arm motor function. In this article, we describe differences in motor function gains among the four participating centers. Three centers showed a tendency favoring robotics whereas one center showed the converse. Results might be accidental considering the small and different number of patients within the centers. However, it indicates that not only study procedures but soft factors that are generally not taken into consideration when planning a multicenter study, such as therapeutic attitude or center differences, might influence the study outcome.
Leitura e escrita em tempos de pandemia: uma proposta por meio do gênero relato de viagem e de experiência vivida com alunos de comunidade ribeirinha

Trabalhar o ensino-aprendizagem da leitura e da escrita no contexto de pandemia tem sido um desafio para o professor. O relato de experiência é resultado de um projeto de leitura e de escrita, o qual fez parte da disciplina de mestrado “Ensinoaprendizagem da leitura e da escrita”. A proposta foi aplicada a alunos do 6º ano do ensino fundamental maior, turmas: “A” e “B”, de uma escola pública de uma comunidade ribeirinha, em Santana/Amapá. A aplicação se deu em aulas online, devido à pandemia da covid-19. O gênero escolhido foi relato de viagem e de experiência vivida, a partir do texto Os Piratas Existem! De Heloísa Schümann. O objetivo da proposta foi estabelecer relações/aproximações entre o gênero e a realidade vivenciada pelos alunos ribeirinhos, a partir do trabalho com a leitura e a escrita, com auxílio do aplicativo WhatsApp. A aplicação do projeto sofreu alterações ao retorno das aulas presenciais. Observou-se o engajamento dos alunos com a leitura e a curiosidade pela história e pelos personagens, despertando sua criatividade e resgatando memórias de vida. As produções desenvolvidas pelos alunos mostram que, apesar de não dominarem alguns recursos linguísticos, conseguem narrar histórias a partir de suas experiências.
Nonlinear supercoherent states and geometric phases for the supersymmetric harmonic oscillator

Nonlinear supercoherent states, which are eigenstates of nonlinear deformations of the Kornbluth-Zypman annihilation operator for the supersymmetric harmonic oscillator, will be studied. They turn out to be expressed in terms of nonlinear coherent states, associated to the corresponding deformations of the standard annihilation operator. We will discuss as well the Heisenberg uncertainty relation for a special particular case, in order to compare our results with those obtained for the Kornbluth-Zypman linear supercoherent states. As the supersymmetric harmonic oscillator executes an evolution loop, such that the evolution operator becomes the identity at a certain time, thus the linear and nonlinear supercoherent states turn out to be cyclic and the corresponding geometric phases will be evaluated.
Car bonnet locking mechanism - has hooked bar with tension spring and locking bar in fixed guide

The locking mechanism is particularly for car bonnets and has a locking bar (1) working in a fixed guide (8), with a stop (14) on the bar working with the guide. There is a control button on one end of the bar, and the other has a hook (4) engaging a locking tongue (5) of sheet metal fixed to the bonnet (6). This latter end also has an anchorage point for a tension spring (15), attached at the other end to the guide. The end of the bar nearest the button is guided between two pins (9, 11) mounted on the guide.
Intergenerational reproduction and solidarity in an era of family complexity

One of the important consequences of the Second Demographic Transition has been the increasing complexity of families. The aim of this project is to study how rising family complexity has affected two fundamental aspects of intergenerational relationships: reproduction and solidarity. Theoretically, family complexity is distinguished into four dimensions: (a) the length, timing and nature of exposure to the child, (c) biological relatedness to the child, and (c) characteristics of parent-parent ties (triadic effects), (d) characteristics of the wider family network. Using insights from several disciplines, I develop a common theoretical framework for understanding intergenerational reproduction and solidarity. To test the theory, an innovative multiactor survey is developed with an oversampling strategy in which for each adult child, information is collected on all parent figures, and for each parent, information on all adult children. In addition, register data are used to analyze one aspect of reproduction in a dynamic fashion (educational reproduction) and vignette data are used to analyze one aspect of solidarity in more depth (norms prescribing solidarity). By studying reproduction and solidarity as outcomes, I shift the traditional focus from examining how the SDT has affected individual well-being, to the question of how the SDT has affected relationships. In doing so, I analyze a new problem in demography and sociology and contribute to classic debates about population ageing and social inequality. Theoretically, the study of family complexity yields unique opportunities to test ideas about the nature of intergenerational relationships and will shed new light on the traditional dichotomy of social vis-à-vis biological bases of intergenerational relationships. Methodological innovation is made by developing solutions for well-known problems of multiactor data, thereby strengthening the theoretical relevance of survey data for the social sciences.
Aluminium’s Advocate. The historical evolution of a European trade association 1981-2021

Cet article retrace l’histoire d’European Aluminium et de ses précurseurs. Il met en lumière les facteurs externes et internes qui ont remodelé cette association et ont contribué au développement des stratégies, des structures et des fonctions de cette association d’entreprises européennes. Créée en 1981, l’Association européenne de l’aluminium (European Aluminium Association : EAA), rebaptisée European Aluminium en 2015, a progressivement évolué pour devenir la voix unique de l’industrie de l’aluminium en Europe, en fusionnant avec d’autres associations, en élargissant ses rôles et en intégrant des fonctions qui, par le passé, avaient été développées par la coopération d’entreprises au niveau mondial. D’une position purement défensive, de nouvelles visions et approches ont émergé et ont transformé European Aluminium en une sorte de « défenseur de l’aluminium » en Europe.
The Effect of Surgical Stress on Serum Prostate Specific Antigen Level

Objective: Invasive surgical interventions creating acute stress may give rise to immunological and hormonal disturbances in patients undergoing surgery. Previous studies reported elevations in serum prostate-specific antigen (PSA) level following coronary bypass and myocardial infarction. The current study aims to investigate the effect of surgical stress on serum PSA level. Methods: Thirty-three patients who underwent open renal stone surgery, without any known infectious prostatic disorder or prostate cancer that may elevate serum PSA level, were included in the study. In all patients, serum levels of total and free PSA (tPSA and fPSA), follicle-stimulating hormone (FSH), luteinizing hormone (LH), total and free testosterone, C-reactive protein (CRP), fibrinogen, albumin, and ferritin and erythrocyte sedimentation rate (ESR) were measured both at baseline and post-operative day 3. Wilcoxon signed-rank test was used for the statistical analysis. Results: The mean age of patients was 53.9±8 (40-66). The mean baseline and post-operative levels of the measured serum parameters are given in Table 1. All of them differed significantly between baseline and post-operative day 3, except for LH, tPSA, and fPSA. CRP, fibrinogen, ferritin, and ESR are known as acute phase reactants of the post-operative endocrine response. However, serum total and free testosterone levels, albumin, and FSH decreased on the contrary acute phase reactants in the present study. Conclusion: According to our results, serum PSA level was not affected by acute surgical stress. (JAREM 2015; 5: 22-4)