SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Idiopathic Granulomatous Mastitis

NTRODUCTION: Idiopathic granulomatous mastitis is defined as granulomatous mastits without any other attributable cause. The condition is diagnosed very rarely. As the diagnosis is a lengthy differential diagnosis of exclusion there is considerable uncertainty about incidence.
CASE REPORT: We present a case of a 37-year-old woman with an abnormal mammography exam. She observed a lump in the right breast about a year and a half ago that grew a lot. Mammography showed a focal assimetric in the upper lateral region of the right breast. Ultrasonography revealed a very suspicious lump in the region of the palpable mass, measuring 3, 5 cm. magnetic resonance imaging (MRI) of the breast revealed dense breasts with marked enhancement. The T2-weighted images showed an area of decreased attenuation, 4, 2 cm in diameter with spiculated borders, in the upper outer quadrant of the right breast. Four days later, a core needle biopsy of the breast mass was performed. Pathological examination of the specimen revealed granulomatous mastitis plus usual ductal hyperplasia. One day before the surgical lumpectomy, she presented with multiple lumps (at least 3) palpable in the same breast. The pathological finding was the same of the core needle biopsy. The treatment with glucocorticoids was started and 2 months later she presented with severe breast pain, no other abnormalities. We introduced endoxifen gel at that time and reduced de corticosteroids dose. One year later, she came to us concerned about local recurrence of a small lump. Again, we introduced oral prednisone and keep a short follow up.
DISCUSSION: Like the diagnosis of sarcoidosis, the diagnosis of granlomatous mastitis requires exclusion of other causes of granulomatous disorders. Granulomatous mastitis may represent a localized autoimmune or hypersensitive response, but no evidence of imunne dysfunction or vasculitis was found in our patient. The clinical response of our patient to a prolonged course of low-dose prednisone was reasonable. The recurrence after one year is of undetermined prognosis, and more studies evaluating the dose, duration, medication and recurrence should be done.
Software for Annotating Videos—A Resource to Facilitate Active Learning in the Digital Age

In many areas of study—especially health professions, visual demonstration of concepts, processes and procedures form an important strategy for teaching and learning. Video recordings can be invaluable in capturing visual components. Annotations add another all-important dimension to the learning value of the video. Our Annotated Video Software is an innovative e-learning tool in support of experiential and self-directed learning. Annotations are independent of the video and the separation of annotation and video provides a robust learning environment that supports content. The tool is user-friendly and instructors can add annotations, without the need for intervention by programmers. Annotations can consist of notes of explanation, complementary videos, links to additional information and questions to engage critical thinking. Students’ answers to questions may also be collected and collated. Upon submission of answers feedback can be displayed, thus transforming evaluation into an immediate learning opportunity. We have already created educational resources for health professionals. Next steps include dissemination of the software to educators, provision of software access by mobile devices and better strategies to incorporate the annotated videos into existing learning management systems.
New sulfonamides containing organometallic-acylhydrazones: synthesis, characterisation and biological evaluation as inhibitors of human carbonic anhydrases

A series of organometallic acylhydrazones was prepared, incorporating Re(CO)3, Mn(CO)3 and ferrocenyl moieties, which were subsequently reacted with amino-sulfonamides in order to obtain carbonic anhydrase (CA, EC 4.2.1.1) inhibitors possessing organometallic moieties in their molecules. The new derivatives were investigated as inhibitors of four human (h) CA isoforms with pharmaceutical applications, such as the cytosolic hCA I, II and VII and the mitochondrial hCA VA. An interesting inhibitory profile against these isoforms was obtained, with some of these metal complexes acting as subnanomolar or low nanomolar inhibitors. They were also thoroughly characterised from the chemical point of view, making them of interest for further developments in the field of metal complexes of sulfonamides with CA inhibitory action.
European standardised process approach to cognitive evaluation in older people

During this fellowship at Dublin City University (Ireland), the researcher will enhance, significantly, the clinical utility of existing traditionally used cognitive tests, particularly as it relates to the early detection and accurate diagnosis of mild cognitive impairment (MCI) and dementia. Cognitive difficulties represent the hallmark of many neurodegenerative conditions and, in relation to dementia, cognitive evaluation represents one major pillar of current methods of detection and diagnosis. There are, however, many difficulties with existing cognitive tests and this project has been designed to address this issue. The need for and the potential benefits of early and accurate detection of MCI and dementia is well-recognised. Early and accurate detection is, however, complex and, at present, is subject to high diagnostic error rates. With the expected advent of new effective drug treatments for different neurodegenerative diseases (e.g. Alzheimer’s disease), early and accurate diagnosis will be even more vital into the future. Using the principles of what is known as the Qualitative Process Approach (QPA), the goal of this project is to identify and develop a battery of cognitive tests, both in traditional paper-and-pencil form and, when clinically appropriate, in a computerised version, with the aim of enabling a wide range of clinicians improve early and accurate diagnosis. This fellowship will play a crucial role in the career of Dr. Unai Diaz Orueta by providing him with international research experience and making him a reference expert in international neuropsychological research. Patients, families and society will benefit for earlier detection, earlier intervention, and reduced healthcare costs, as the improvement in the accuracy of the diagnosis of neurodegenerative conditions will subsequently impact in planning appropriate early interventions and saving millions of Euros associated to both formal and informal care of older people with dementia.
Spatiotemporal variation among demersal ichthyofauna in a subtropical estuary bordering World Heritage-listed and marine protected areas: implications for resource management

Benthic trawl surveys were performed to quantify the spatiotemporal distributions of teleosts and key abiotic associations throughout an ecologically important estuary within Brazil’s Atlantic Forest biosphere. Approximately 52000 fish (51% juveniles) representing 75 species were sampled, with residents accounting for 36 and 61% of total species and individuals respectively. Five artisanally important species comprised 77 and 81% of individuals and biomass respectively. Cathorops spixii was most abundant (&gt;40% of total), whereas Stellifer rastrifer, Aspistor luniscutis, Sphoeroides greeleyi and S. testudineus collectively contributed towards 37 and 34% of individuals and biomass respectively. The abundance of A. luniscutis, C. spixii and S. rastrifer was negatively associated with salinity, whereas the presence of the latter two species was also positively associated with temperature, and S. greeleyi and S. testudineus (mostly adults) were more abundant in deeper areas. These relationships seemed to be affected by species-specific reproductive (S. rastrifer, C. spixii and A. luniscutis), habitat (S. greeleyi and S. testudineus) and prey preferences (juvenile C. spixii and A. luniscutis). Protection for these various species may be achieved via immediate fishing effort regulations, but more research is required to manage other anthropogenic effects. Such work should be a priority to ultimately preserve what is one of the most important South American biodiversity areas.
The spatial dynamics of room acoustics

The SONORA project aims to increase the general understanding of how complex sound scenes are impacted by the spatial dynamics of room acoustics. This knowledge is crucial in the design of signal processing algorithms for audio acquisition and reproduction problems in real-life situations, where moving sound sources and observers interact with room acoustics in a complicated manner.
A major part of the project will be devoted to the development of novel room acoustics models and to the unification of existing models. The room acoustics models developed in this project will be data-driven models with a physically motivated structure, and are expected to fill the existing gap between geometric and wave-based models. This will be achieved by formulating existing and novel models in a dictionary-based mathematical framework and introducing a new concept coined as the equivalent boundary model, aimed at relaxing the prior knowledge required on the physical room boundary.
A second part of the project will focus on the development of a protocol for measuring spatiotemporal sound fields. This protocol will be rooted in a novel sound field sampling theory which exploits the spatial sparsity of sound sources by invoking the compressed sensing paradigm.
Thirdly, novel signal processing algorithms capable of handling spatiotemporal sound fields will be designed. By employing recent advances in large-scale optimization and multidimensional scaling, fast and matrix-free algorithms will be obtained that do not require prior knowledge of the sound scene geometry. 
The SONORA research results are anticipated to have a notable impact in various audio acquisition and reproduction problems, including acoustic signal enhancement, audio analysis, room inference, virtual acoustics, and spatial audio reproduction. These problems have many applications in speech, audio, and hearing technology, hence a significant benefit for industry and for technology end users is expected in the long run.
La autonomía privada en el contrato leasing

ABSTRACT
The objective of the present investigation was to determine how to achieve the application and primacy of the private autonomy of the parties in the leasing contract without ignoring the will, freedom and equality of the tenant. For the verification of the hypothesis, a sample constituted by 10 experts in financial leasing contract analysis divided into: 06 users and 04 financial entities was considered. As well as the statistical reports of the financial leasing contracts of the ASBAC, 2016-2017, and the regulations that regulate it. In order to obtain the information, the techniques of documentary analysis, the signing and the survey were used, with their respective data collection instruments. This information was organized and presented in tables and frequency figures. Likewise, the inductive-deductive, analysis-synthesis and hermeneutic methods were used to discuss the information obtained from the elements of the sample. The results allowed to conclude that the application and primacy of the Principle of Private Autonomy of the tenant, in the financial leasing contract within the framework of constitutionally regulated contractual freedom, is achieved by granting personal decision to the tenant in the free pact of the minimum insurance conditions that covers the goods subject of financial leasing, since Legislative Decree 299 is distorted, coerces the contractual freedom and imposes the financial obligation on the business need.
Estimation of orbit change and emittance growth due to random misalignment in long linacs

In linear accelerators, the transverse beam orbit is induced by tilts of accelerating cavities (deviation of accelerating field direction from designed beam direction) and transverse offset of quadrupole magnets. Estimating induced orbit and emittance growth due to such random errors is important for evaluation of performance of linacs, especially where stable and low emittance beam is required, such as linear colliders. Usually, such estimations are performed using tracking simulations, including the Monte Carlo method, which tends to take a long time. Here, a much faster and simpler method of quantitative estimation of beam orbit and emittance growth is reported. This method is valid for very long linacs with many components, where statistical treatment of errors is justified. It is shown that the results from the method agree well with tracking simulations for the ILC (International Linear Collider) main linac.
Monitoring the effect of a control pulse on a conical intersection by time-resolved photoelectron spectroscopy

We have previously shown how femtosecond angle- and energy-resolved photoelectron spectroscopy can be used to monitor quantum wavepacket bifurcation at an avoided crossing or conical intersection and also how a symmetry-allowed conical intersection can be effectively morphed into an avoided crossing by photo-induced symmetry breaking. The latter result suggests that varying the parameters of a laser to modify a conical intersection might control the rate of passage of wavepackets through such regions, providing a gating process for different chemical products. In this paper, we show with full quantum mechanical calculations that such optical control of conical intersections can actually be monitored in real time with femtosecond angle- and energy-resolved photoelectron spectroscopy. In turn, this suggests that one can optimally control the gating process at a conical intersection by monitoring the photoelectron velocity map images, which should provide far more efficient and rapid optimal control than measuring the ratio of products. To demonstrate the sensitivity of time-resolved photoelectron spectra for detecting the consequences of such optical control, as well as for monitoring how the wavepacket bifurcation is affected by the control, we report results for quantum wavepackets going through the region of the symmetry-allowed conical intersection between the first two (2)A' states of NO(2) that is transformed to an avoided crossing. Geometry- and energy-dependent photoionization matrix elements are explicitly incorporated in these studies. Time-resolved photoelectron angular distributions and photoelectron images are seen to systematically reflect the effects of the control pulse.
Walking the Natural-History Trail

Abstract: Natural-history studies represent the observational stage of the scientific method, and the single greatest discovery in biological sciences, evolution by natural selection, was based largely on a vast amount of natural-history information collected by Charles Darwin. I briefly review natural-history observations that I have made during my career that led to discoveries in life-history theory, placentation in New World Mabuya that rivals that of eutherian mammals, social behavior in the North American clade of five-lined skinks, and the relationship of ecological traits of lizards globally to their evolutionary history (phylogeny). Gifted collaborators provided the intellectual interplay that led to these discoveries, and they certainly deserve as much credit as I do. I briefly comment on what I consider to be frontiers in herpetology that involve combining phylogenetic hypotheses with natural-history data. In a final comment, I encourage those among us who are able to spend extended time period...
Symptom Validity Testing in Medically Unexplained Pain: A Chronic Regional Pain Syndrome Type 1 Case Series

This study examines validity findings in a particular behavioral pain disorder. We examined two types of validity scores in 73 participants with a primary diagnosis of the controversial Complex Regional Pain Syndrome Type I (CRPS-1). All participants were incentivized by a disability-seeking context. Failure rates on performance validity tests ranged from 23% (Test of Memory Malingering) to 50% (Reliable Digit Span). Positive findings on symptom validity tests (MMPI-2 or MMPI-2-RF) ranged from 15% to 50% of subsamples. At least 75% of the sample failed one performance validity indicator and over half showed at least one positive symptom validity score. This initial study suggests that CRPS-1 could serve as a good patient model for studying the role of simulation in pain-related disability.
Toxic Leukoencephalopathy after Heroin Abuse without Heroin Vapor Inhalation

Toxic leukoencephalopathy has been associated with illicit heroin vapor inhalation. Despite the nonspecific and variable clinical presentation of these patients, they show typical radiologic findings. Previous studies evaluated typical radiologic findings with symmetric infratentorial hyperintense signal changes and similar alteration in the posterior limb of the internal capsule, the splenium of corpus callosum, the medial lemniscus and the lateral brainstem. In context with the reviewed literature, a series of another three cases with toxic leukoencephalopathy after heroin abuse other than vapor inhalation is presented.All three patients underwent magnet resonance imaging (MRI) including additional diffusion- weighted imaging and apparent diffusion coefficient maps. Clinical and laboratory findings were recorded.MRI of all three patients revealed similar symmetric supratentorial hyperintense signal changes involving the frontal, parietal, occipital and temporal lobes. The cortex was spared and the subcortical U fibers were partially involved. Further, the brainstem and the cerebellar white matter were not affected.Toxic leukoencephalopathy without involvement of the cerebellum and brainstem is a rare complication of heroin abuse. The pattern of heroin-induced toxic leukoencephalopathy on MRI might not only be related to an unknown adulterant, but also to the mode of drug administration.
Research Progress of Soil Organic Carbon Transfer to Soil Inorganic Carbonates in Forest and Grassland Soil in Northwest Arid Areas

The soil carbon in arid regions is an important component of the global carbon pool.Northwest arid area includes larger proportion soil inorganic carbon.Through the SOC-CO2-SIC micro-carbon cycle,the soil organic carbon can transfer to the soil inorganic carbon.To study the migration and transformation process and estimate the transfer amount can expose part of the missing carbon sink.This paper described the mechanism of the transfer and introduced several methods to calculate the amount of carbon transfer.We contrasted to these methods,and expounded the biogeochemical ways of stable isotope techniques.Problems existed in the research were discussed.It was found the few research was carried out in the area.Many uncertainties existed in the process of calculating the amount of carbon transfer and the distinction from CO2 of soil.Most results were only from estimation.It was suggested that the study of impact factor of the SOC transfer to the SIC should be strengthened to reduce the test errors.
Why are More Sovereigns Issuing in Euros? Choosing between USD and EUR-Denominated Bonds

This paper presents and discusses the arguments offered by several sovereigns that have joined a trend starting in 2013 whereby sovereign and corporate issuers, especially in Latin America, have gradually replaced a portion of the funding raised in U.S. dollars with euros. The trend seems to respond to the divergent monetary policies followed by the U.S. Federal Reserve Board and the European Central Bank. The selected country cases state strategic and tactical arguments for increasing their issuance in euros. The strategic reasons relate to internal currency benchmarks and their rationale. In some cases, such substitution is supported by the argument that further diversification in the investor base was needed. This argument was reinforced by the relatively tight conditions in the U.S. dollar market. Tactical arguments refer to the need to open the market to the private sector and raise funding in euros, or the need to access new investors as a preliminary step to attract them to the domestic market. Several countries also admit that the optical effect of lower coupons was a relevant consideration. This paper highlights that it is important that sovereigns avoid making decisions by comparing nominal coupons in both currencies. More important, a formal debt management strategy, including a target for the currency composition, should guide debt managers. Without a strategy, the debt manager cannot tell how the issuance in a particular currency affects the exposure of the debt portfolio to foreign currency risk and helps or not in achieving the debt management objectives.
Evaluating Anisotropic Properties in the Porcine Temporomandibular Joint Disc Using Nanoindentation

The objective of this study was to determine the viscoelastic properties present within the intermediate zone of the porcine temporomandibular joint (TMJ) disc using nanoindentation. A 50-microm conospherical indenter tip using a displacement-controlled ramp function with a 600 nm/s loading and unloading rate, a 3000-nm peak displacement with a holding period of 30 s was used to indent the samples. Experimental load-relaxation tests were performed on the TMJ disc to determine the response in three different directions; the mediolateral, anteroposterior, and articular surface directions. The experimental data were analyzed using a generalized Maxwell model to obtain values for short- and long-time relaxation modulus and of material time constants. The short time relaxation modulus E ( I ) values were 180.92, 64.99, and 487.77 kPa for testing done on the articular surface, mediolateral, and anteroposterior directions, respectively. Corresponding values for the long-time relaxation modulus E (infinity) were 45.9, 14.97, and 133.5 kPa. The method confirmed anisotropy present within the central intermediate zone of the porcine TMJ disc due to the directional orientation of the collagen fibers.
The unique “nanny” sensor and app that cares and engages growers through the hydroponic process

Business Opportunity:. Hydroponics is a closed-loop food production system in a controlled environment and grows without soil, also known as soilless growing. It is a sustainable solution for meeting growing demand of food consumption, reduces water waste (+70%) and contamination, increases crop production and enhances the community environmental-care feelings. Despite advantages, the process must be professionally controlled to avoid constant losses ending of users’ disappointment.
Easyponic endeavours to scale-up a cost-effective, easy-to-use ICT based product that provides a solution to control the whole hydroponic process without having a professional knowledge of the methodology. Easyponic is based on a compacted hardware the “Nanny” that cares about the crops and automates the monitoring process by sending the user all the information and actions that should be taken though a mobile application, which engages the users through its gaming features.
Easyponic targets Non-professional growers (B2C) & Small-medium greenhouse farmers (B2B) providing both with a cost-effective solution that engage the user and controls the process through the value of information, preventing alarms and training.
Easyponic has gone through processes of “design thinking” and “customer discovery & validation” - with more than 95k€ already invested - at the national level (TRL6). Our successful demonstration results position us to continue to advance during the next phases in the validation process under the SME Phases 1 and 2, going from TRL6 to TRL9.
Easyponic aims to get 44,5 M€ of incomes by 2021 targeting EU, US and Indian Markets