SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Humoral- and T-Cell–Specific Immune Responses to SARS-CoV-2 mRNA Vaccination in Patients With MS Using Different Disease-Modifying Therapies

To evaluate the immune-specific response after full severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination of patients with multiple sclerosis (MS) treated with different disease-modifying drugs by the detection of both serologic and T-cell responses.Healthcare workers (HCWs) and patients with MS, having completed the 2-dose schedule of an mRNA-based vaccine against SARS-CoV-2 in the past 2-4 weeks, were enrolled from 2 parallel prospective studies conducted in Rome, Italy, at the National Institute for Infectious diseases Spallanzani-IRCSS and San Camillo Forlanini Hospital. Serologic response was evaluated by quantifying the region-binding domain (RBD) and neutralizing antibodies. Cell-mediated response was analyzed by a whole-blood test quantifying interferon (IFN)-γ response to spike peptides. Cells responding to spike stimulation were identified by fluorescence-activated cell sorting analysis.We prospectively enrolled 186 vaccinated individuals: 78 HCWs and 108 patients with MS. Twenty-eight patients with MS were treated with IFN-β, 35 with fingolimod, 20 with cladribine, and 25 with ocrelizumab. A lower anti-RBD antibody response rate was found in patients treated with ocrelizumab (40%, p < 0.0001) and fingolimod (85.7%, p = 0.0023) compared to HCWs and patients treated with cladribine or IFN-β. Anti-RBD antibody median titer was lower in patients treated with ocrelizumab (p < 0.0001), fingolimod (p < 0.0001), and cladribine (p = 0.010) compared to HCWs and IFN-β-treated patients. Serum neutralizing activity was present in all the HCWs tested and in only a minority of the fingolimod-treated patients (16.6%). T-cell-specific response was detected in the majority of patients with MS (62%), albeit with significantly lower IFN-γ levels compared to HCWs. The lowest frequency of T-cell response was found in fingolimod-treated patients (14.3%). T-cell-specific response correlated with lymphocyte count and anti-RBD antibody titer (ρ = 0.554, p < 0.0001 and ρ = 0.255, p = 0.0078 respectively). IFN-γ T-cell response was mediated by both CD4+ and CD8+ T cells.mRNA vaccines induce both humoral and cell-mediated specific immune responses against spike peptides in all HCWs and in the majority of patients with MS. These results carry relevant implications for managing vaccinations, suggesting promoting vaccination in all treated patients with MS.This study provides Class III data that SARS-CoV-2 mRNA vaccination induces both humoral and cell-mediated specific immune responses against viral spike proteins in a majority of patients with MS.
Winning social acceptance for wind energy in wind energy scarce regions

The overall objective of WinWind is to enhance the socially inclusive and environmentally sound market uptake of wind energy by increasing its social acceptance in 'wind energy scarce regions' (WESR). The specific objectives are: screening, analysing, discussing, replicating, testing & disseminating feasible solutions for increasing social acceptance and thereby the uptake of wind energy. The proposal considers from a multidisciplinary perspective the case of WESR in DE, ES, IT, LV, PL and NO. These selected countries represent a variety of realities ranging from large (but with WESR) to very scarce wind energy penetration.  WinWind analyses regional and local communities´ specificities, socioeconomic, spatial & environmental characteristics and the reasons for slow market deployment in the selected target regions. Best practices to overcome the identified obstacles are assessed and – where feasible – transferred. The operational tasks are taken up by national/regional desks consisting of the project partners, market actors and stakeholders in each country. 
The project´s objectives will be reached by: i) analysing the inhibiting and driving factors for acceptance, ii) developing a taxonomy of barriers to identify similarities and differences in development patterns , iii) carrying out stakeholder dialogues in all participating regions, iv) developing acceptance-promoting measures that are transferable to specific local, regional and national contexts, and v) transferring feasible best practice solutions via learning labs. WinWind develops concrete solutions. The activities focus on novel informal/voluntary procedural participation of communities, direct and indirect financial participation & benefit sharing. Finally, policy lessons with validity across Europe are drawn and recommendations proposed. Already 62 stakeholders and market actors provided letters of support showing their commitment in supporting the WindWind activities and in implementing useful results.
PAINTING SYSTEM

A painting system for painting the wheel sets (10) of rail vehicles, with at least one painting chamber (12) which is provided with a rail (14), on which the wheel set (10) which is to be painted can be moved, and with a painting robot (16), in which painting system a rail section within the painting chamber (14) is arranged on a plate (18) which is rotatable through at least + 90° or 270°, the rail section running on the plate (18) is provided with an interruption in the centre, and the plate (18) is provided with at least one pair of driving wheels (20) entering into frictional engagement with the running surface of a wheel or the rim of a wheel through the interruption in the rail section and thus rotating the wheel set (10) during the painting thereof by the painting robot (16).
H-Bonded metallomesogens derived from salicyladiminates

Abstract A series of new mesogenic compounds 1a–b (n=8, 10, 12, 14, 16) derived from salicyladimines and their palladium 2a, 2b, vanadyl 2a, and copper complexes 3a, 3b were prepared and their mesomorphic properties investigated by optical microscopy, differential scanning calorimetry and powder X-ray diffractometry. Pd2+ and VO2+ ions formed mononuclear complexes, whereas, Cu2+ ion formed binuclear complexes due to the relative acidic strength of Schiff base. Single crystallographic analysis of non-mesogenic compound 2a (n=8) confirmed its coordination geometry at Pd2+ as square plane. It crystallizes in a triclinic space group P−1 with a Z=1. As expected, the Pd2+ was coordinated via a trans-N2O2 donor set of phenolic–O and imine-N atoms, leaving two hydroxyl groups intact and uncoordinated. The two alkoxy chains, pointing to the opposite direction were parallel, and the molecule was considered as twisted Z-shaped. Both hydroxyl-OH groups attached on C17 and C18-Schiff imines participate in the H-bonds in the lattice. Interestingly, a pseudo polymeric structure was observed, in which H-bonded dimer was continuously extended by another H-bonded dimer in the lattice. Compounds 1 exhibited smectic A phases, and Pd and VO complexes and Cu complexes 3b exhibited smectic A or/and smectic X phases, however, Cu complexes 3a formed crystal phases. Intermolecular H-bonds might be attributed to the difference observed on the mesomorphic properties in these compounds. Copper complexes 2b were not active on ESR spectroscopy.
A Cholesterol and Actinide Dependent Shadow Biosphere of Archaea And Viroids in Neoplastic Disorders

Background: Endogenous digoxin has been related to the pathogenesis of non-hodgkin’s lymphoma, multiple myeloma and CNS glioma. The possibility of endogenous digoxin synthesis by archaea with a mevalonate pathway and cholesterol catabolism was considered. Methods: 10 cases each of non-hodgkin’s lymphoma- diffuse large B cell type, multiple myeloma and CNS glioma- glioblastoma multiforme before starting treatment and 10 age and sex matched healthy controls from general population were chosen for the study. Cholesterol substrate was added to the plasma of the patients and the generation of cytochrome F420, free RNA, free DNA, polycyclic aromatic hydrocarbon, hydrogen peroxide, serotonin, pyruvate, ammonia, glutamate, cytochrome C, hexokinase, ATP synthase, HMG CoA redutase, digoxin and bile acids were studied. The changes with the addition of antibiotics and rutile to the patient’s plasma were also studied. Results: The parameters mentioned above were increased the patient’s plasma with addition of cholesterol substrate. The addition of antibiotics to the patient’s plasma caused a decrease in all the parameters while addition of rutile increased their levels. Conclusion: An actinide dependent shadow biosphere of archaea and viroids is described in non-hodgkin’s B cell lymphoma, multiple myeloma and CNS glioma- glioblastoma multiforme producing the Warburg phenotype contributing to their pathogenesis. Key words : Archaea; Viroids; Cholesterol; Actinide; Non-hodgkin’s lymphoma; Multiple myeloma; CNS glioma
Computational laser intensity stabilisation for organic molecule concentration estimation in low-resource settings

An ideal laser is a useful tool for the analysis of biological systems. In particular, the polarization property of lasers can allow for the concentration of important organic molecules in the human body, such as proteins, amino acids, lipids, and carbohydrates, to be estimated. However, lasers do not always work as intended and there can be effects such as mode hopping and thermal drift that can cause time-varying intensity fluctuations. The causes of these effects can be from the surrounding environment, where either an unstable current source is used or the temperature of the surrounding environment is not temporally stable. This intensity fluctuation can cause bias and error in typical organic molecule concentration estimation techniques. In a low-resource setting where cost must be limited and where environmental factors, like unregulated power supplies and temperature, cannot be controlled, the hardware required to correct for these intensity fluctuations can be prohibitive. We propose a method for computational laser intensity stabilisation that uses Bayesian state estimation to correct for the time-varying intensity fluctuations from electrical and thermal instabilities without the use of additional hardware. This method will allow for consistent intensities across all polarization measurements for accurate estimates of organic molecule concentrations.
A Trend Tracking Strategy for Gold Future: An Artificial Neutral Network Analysis

In this paper, we construct a simple data-driven trend tracking strategy for gold future in a view of contrarians. The artificial neutral network (ANN) is adopted to determine the price trend signal, by which the degree of tightness could be adjusted based on observed data. We attempt to capture the small profits when the price is deviated from the Bollinger band in the gold future market by intraday trading. High frequency data of gold future is used to train and test the strategy. Despite of the trading cost, the back-tests show that our strategy has delivered positive returns and is adaptive to different price trends. Finally, we evaluate the profitability with the consideration of trading cost, revealing that the strategy is applicable in practice.
The geometry of Strombolian explosions: insights from Doppler radar measurements

SUMMARY

Observations of Strombolian volcanic explosions were carried out at Etna's southeast crater on 2001 July 4 using a ground-based pulsed Doppler radar (VOLDORAD). To obtain quantitative constraints on the geometry of the explosions, we modelled synthetic Doppler spectra by combining the outputs of a ballistic model to compute the theoretical velocities of gas and particles, and an electromagnetic scattering model to calculate the synthetic echo power. This allowed us to reproduce the shapes of recorded Doppler spectra for each volcanic explosion. We examined the geometrical distribution of ejected pyroclasts for about 200 explosions and found two main types of explosion, each showing a distinctive spectral signature. The first type, characterized by the triangular shape of their Doppler spectra, represents 34 per cent of the explosions. This spectrum shape is related to a Gaussian distribution of the pyroclast ejection angles, where most of the volcanic material is ejected vertically within a narrow cone, with the particle concentration decreasing radially. The second type represents about 12 per cent of the explosions, and is characterized by a top-hat-shaped spectrum. It is produced by a uniform distribution of pyroclast ejection angles. In this case, the bubbles tend to burst above the crater rim and eject the ballistic clasts hemispherically without preferential orientation. The majority of the Strombolian explosions analysed (54 per cent) are intermediate between these end-member shapes, and show a triangular spectra truncated by a plateau. They result from a uniform distribution of ejection angles around the jet axis.



The continuous radar recordings allowed us to carry out a statistical analysis on the geometrical features of the same 200 Strombolian explosions. Thus we find that 40° is a statistically representative aperture of the dispersion cone characterized by uniform ejecta distribution for explosions having a plateau component (i.e. 2/3 of all explosions studied). We also find that 80 per cent of the total particle load remains within this 40° dispersion cone, which in our case is oriented nearly vertically. Such quantification of the geometrical features of Strombolian explosions can provide constraints on shallow conduit processes. For example, the time evolution of the top-hat Doppler spectra during the paroxysm suggests that the magma level varies over a 15 min timescale.
Impact of SARS-CoV-2 Delta variant on incubation, transmission settings and vaccine effectiveness: Results from a nationwide case-control study in France

We aimed to assess the settings and activities associated with SARS-CoV-2 infection in the context of B.1.617.2 (Delta) variant circulation in France, as well as the protection against symptomatic Delta infection.In this nationwide case-control study, cases were SARS-CoV-2 infected adults recruited between 23 May and 13 August 2021. Controls were non-infected adults from a national representative panel matched to cases by age, sex, region, population density and calendar week. Participants completed an online questionnaire and multivariable logistic regression analysis was used to determine the association between acute SARS-CoV-2 infection and recent activity-related exposures, past history of SARS-CoV-2 infection, and COVID-19 vaccination.We did not find any differences in the settings and activities associated with Delta versus non-Delta infections and grouped them for subsequent analyses. In multivariable analysis involving 12634 cases (8644 Delta and 3990 non-Delta) and 5560 controls, we found individuals under 40 years and attending bars (aOR:1.9; 95%CI:1.6-2.2) or parties (aOR:3.4; 95%CI:2.8-4.2) to be at increased risk of infection. In those aged 40 years and older, having children attend daycare (aOR:1.9; 95%CI:1.1-3.3), kindergarten (aOR:1.6; 95%CI:1.2-2.1), primary school (aOR:1.4; 95%CI:1.2-1.6) or middle school (aOR:1.3; 95%CI:1.2-1.6) were associated with increased risk of infection. We found strong protection against symptomatic Delta infection for those with prior infection whether it was recent (2-6 months) (95%; 95%CI:90-97) or associated with one dose (85%; 95%CI:78-90) or two doses of mRNA vaccine (96%; 95%CI:87-99). For those without past infection, protection was lower with two doses of mRNA vaccine (67%; 95%CI:63-71).In line with other observational studies, we find reduced vaccine effectiveness against symptomatic Delta infections. The settings and activities at increased risk of infection indicate where efforts to reinforce individual and public health measures need to be concentrated.
GENERATION OF DIVERSITY IN COMBINATORIAL LIBRARIES

The invention concerns gene banks and combinatorial derivatives thereof, prepared using phagemid- or phage-display in combination with type IIS restriction enzymes and cosmid packaging; their use for the isolation of ligands, including enzyme inhibitors, agonists and antagonists for receptors, competitive binding peptides to a defined target, diagnostic ligands for diseases and autoimmune syndromes, including surveillance tools for immune status, post-translationally modified peptides, and such ligands generated by this technology.
The design and implementation of a workflow system for enterprise project management

In Enterprise Project Management, Workflow system can control and manage project process, help enterprise improving efficiency, reduce production cost, and improve enterprise's productivity and competitiveness. This paper designs and implements a workflow system for enterprise project management. The design and implementation technology of workflow system are described. The composition of workflow system has three layers, which include user interface layer, workflow operation layer and data management layer. The system can fulfill the automatic control of project management and implement Multi-task display, process approval, task plan, task assignment and some related work about enterprise project management. Practice verified, the workflow system can be applied in enterprise project management stably and safely.
The Impact of Strategy Performance Management Methods on Employee Well-Being: A Case Study to Analyses Balanced Scorecard Effects

In today's economic conditions, it has become mandatory for organizations to use performance measurement methods due to increasing competition conditions. The study investigates the effect of the Balanced Scorecard, one of the performance measurement systems, on employee well-being (EWB) in organizations. As a result of the literature research, it is seen that employee welfare is examined in 3 different areas: Job Satisfaction, Organizational Commitment, and Job Engagement. One of the most important factors for the success of an organization is the happy employees who contribute tremendously to the improvement of the organization's performance.Both qualitative and quantitative measurement methods were used for this study. The surveys that have used for this study included 27334 employees in the state of Michigan and the surveys data were analyzed by Statistical Package for Social Sciences (SPSS) 28. The study revealed that the BSC strategies implemented in the State of Michigan improved organizational performance in the four perspectives of financial, customer, internal process, and learning & growth. The statistical results of employee satisfaction surveys show that BSC increases job satisfaction by 68.30% (R-squared: 0.683), work engagement by 71.00% (R-squared: 0.710), and organizational commitment by 21.30% (R-squared: 0.213). With the BSC strategy and learning-growth perspective that has been in effect for 20 years, employee satisfaction has been increased, organizational commitment and job engagement have been prioritized in the State of Michigan. The result of this study will help leaders and HR departments measure and increase employee well-being with performance measurement tools.
Cycling for development, growth and quality of life in European regions

EU CYCLE aims at improving performance of 4 policy instruments addressed through interregional learning and regional action planning. It will thereby contribute to better quality cycling projects, to raise share of cycling in target regions via improved policies and state-of-the art solutions, with a higher impact on decarbonizing transport.

The common challenge lies in the fact that although cycling related projects were supported by approximately €0.6bn EU subsidies between 2007-2013, good practices were not shared and knowledge about them is unevenly distributed in regions involved, so not taken up by their policy instruments. Since MAs, regional stakeholders and potential project holders aren’t aware of good practices and of advantages of potential adaptation, lack of knowledge decreases interest in developing cycling projects and risk that the allocated budget for cycling in the policy instruments addressed are spent effectively. 

Partners, all previously involved in INTERREG projects on different subtopics -regional cycling, cycling tourism, urban cycling, intermodality, urban-rural connections, territorial cooperation in cycling- have decided sharing their experiences to increase capacities of using available funds fully and in an efficient way for quality cycling projects. 

Partners’ relevant experiences in the 6 subtopics will be shared, jointly analyzed and fed into the Interreg Europe Policy Learning Platform’s database. Partners will work with regional stakeholders on adapting experiences learned in 4 regional Action Pans, improving their policy instruments’ results. An Integrated Cycling Planning Guide will be jointly elaborated to summarize best solutions in technical aspects of cycling.

EU CYCLE will increase capacities both on the governance side of policy instruments and on the side of potential beneficiaries to develop and realize projects.
Spinel and orthopyroxene exsolved from clinopyroxene in the Haladala pluton in the middle Tianshan (Xinjiang, China)

The Haladala pluton, consisting of troctolite, olivine gabbro and gabbro with zircon SHRIMP U-Pb age of 309 ± 2 Ma (MSWD = 0.72), intruded the Devonian-Carboniferous arc segments in the middle Tianshan. Amphibole, coexisting with magnetite, amphibole, and phlogopite, crystallized in a magma chamber at depth of ~ 20 km (6.9–7.4 kbar, 934–943 °C) based on various thermobaramoters. Two kinds of exsolution textures (spinel rods in clinopyroxene, orthopyroxene lamellae in clinopyroxene) occur in troctolite and olivine gabbro. We describe oriented spinel rods and orthopyroxene lamellae exsolved from the host clinopyroxene based on optical and high-resolution transmission electron microscope (HRTEM) observations. The spinel rods (100) are parallel to their host clinopyroxene (010). Orthopyroxene lamellae (010) are coherent and strictly parallel to their host clinopyroxene (010). Exsolution of spinel rods from the host clinopyroxene is controlled by the reaction of (Ca0.5M2+
 0.5)Fe3+[AlSiO6]in clinopyroxene → (Ca0.86−0.17M2+
 0.14−0.17)(M2 + 1.00−0.96Al0−0.04)[Al0.17−0.10Si1.83−1.90O6] + Fe3O4 + O2.
One orchestrator for all kinds of clouds

Since there is not one-fits-all cloud approach, more and more companies demand the combination of multiple clouds to meet their needs. Against this background, technologies and techniques to manage resources and services will play a central role in the development of Hybrid clouds and multicloud.
The boost in the number of companies with Hybrid Clouds and multiclouds call for new innovations to orchestrate services in order to facilitate the programmatic provisioning and releasing of resources.
Walhalla Data Centre Services is a technology company that has the knowledge, experience and infrastructure to provide PUBLIC, PRIVATE or HYBRID CLOUD Solutions with open orchestrator for mission-critical data and applications. We have developed WOTAN to overcome management of resources complexities in hybrid and multicloud cloud architectures. WOTAN is able to orchestrate the widest variety of public and private clouds with Multi-cloud and Hybrid clouds solutions. 
WOTAN offers some unique capabilities.
•	Automatic replication of a virtual data centre between two clouds.
•	Mechanism to automatically move a virtual machine with a critical application from a host that goes down to other host.
•	Bidirectional transfer of data between a Cloud and an EFS&S solution (Enterprise File Sharing & Synchronization).
We think that these capabilities imply a disruptive innovation in the field of cloud orchestration and they are highly demanded by the market. We are sure that they will position us as a new leader company in the provision of cloud infrastructure. 
For that reason, WOTAN will play a central role in the evolution of Walhalla DCS and it will be the product that will allow us to address the market with a global ambition. Our first estimations show that this platform will require an investment of 1.35M€ and would suppose the creation of 20 jobs and a ROI of 6.26