SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
The value of diagnostics to combat antimicrobial resistance by optimising antibiotic use

Antimicrobial resistance (AMR) is of great public health concern, causing numerous losses of lives worldwide and threatening to reverse many of the considerable strides modern medicine has made over the last century. There is a need to stratify antibiotic and alternative treatments in terms of the actual benefit for the patient, improving patient outcome and limit the impact on AMR. High quality, effective and appropriate diagnostic tests to steer appropriate use of antibiotics are available. However, implementation of these tests into daily healthcare practice is hampered due to lack of insight in the medical, technological and health economical value and limited knowledge about psychosocial, ethical, regulatory and organisational barriers to their implementation into clinical practice.

VALUE-Dx will define and understand these value indicators and barriers to adoption of diagnostics of Community-Acquired Acute Respiratory Tract Infections (CA-ARTI) in order to develop and improve health economic models to generate insight in the whole value of diagnostics and develop policy and regulatory recommendations. In addition, efficient clinical algorithms and user requirement specifications of tests will be developed fuelling the medical and technological value of CA-ARTI diagnostics. The value of diagnostics will be tested and demonstrated in a unique pan-European clinical and laboratory research infrastructure allowing for innovative adaptive trial designs to evaluate novel CA-ARTI diagnostics. Close and continuous interaction with the VALUE-Dx multi-stakeholder platform provides for optimal alignment of VALUE-Dx activities with stakeholder opinions, expert knowledge and interests. 

A variety of dissemination and advocacy measures will promote wide-spread adoption of clinical and cost-effective innovative diagnostics to achieve more personalized, evidence-based antibiotic prescription in order to transform clinical practice, improve patient outcomes and combat AMR.
Productive spatial accelerator programming

We propose a productive and efficient programming model to overcome the challenges posed by the end of Moore’s law. Our model bases on a fundamentally new spatial viewpoint that considers the computational structure of applications. The growth of the computing industry as well as the development of society at large has relied for 50 years on an exponential scaling law that is now coming to an end. The combination of multiple specialized components into a fundamentally heterogeneous system is one of the most promising approaches that drives the IT industry. Latest advances in computer architecture and silicon design enable cost-effective specialized accelerators. Those range from single-purpose designs, such as deep neural network chips, to general purpose graphics processing units and are combined into complex systems. However, programming these heterogeneous spatial systems that range from single systems on chip to million-core supercomputers is a fundamental challenge of our time. Prevalent parallel programming abstractions largely ignore the structure of the computation and guide programmers to design threads of execution that are scheduled to the machine. We depart from this temporal model to a spatial formulation where we express programs as parametric graphs that are mapped as first-class objects by a human-guided compilation system. We ensure productivity by designing a Python-based frontend and integrate the system with modern web technology. Our programming, compilation, and tuning system will substantially advance the state of the art in computing by supporting the graphical mapping of program graphs to spatial accelerators. We will demonstrate our methods on three challenging real-world applications in important domains. We strongly believe that, without holistic spatial programming, the growing complexity and inefficiency of heterogeneous programming will create a scaling wall that will severely limit our future computational capabilities.
METHOD FOR GENERATING OLIGONUCLEOTIDES, IN PARTICULAR FOR THE DETECTION OF AMPLIFIED RESTRICTION FRAGMENTS OBTAINED USING AFLP3

The invention relates to a method for generating, and optionally detecting, an oligonucleotide, comprising at least the steps of: a) providing a first <i>ds</i>DNA; b) ligating the first <i>ds</i>DNA to a second <i>ds</i>DNA, in which said second <i>ds</i>DNA sequence comprises within its sequence at least one recognition site for an IIS restriction endonuclease; so as to provide a ligated <i>ds</i>DNA; d) restricting the ligated <i>ds</i>DNA with the at least one restriction endonuclease of the IIS type so as to obtain at least a first and a second IIS-restricted <i>ds</i>DNA; and optionally comprising the further step of: e) detecting the first and/or second IIS-restricted <i>ds</i>DNA obtained in the restriction step d). Preferably, said method comprises the further step of: c) amplifying the ligated <i>ds</i>DNA obtained in the ligating step b) prior to the restriction step d). The detection step e) preferably comprises the steps of: 1) generating at least one <i>ss</i>DNA from either the first or the second IIS-restricted <i>ds</i>DNA obtained in the restriction step d); 2) detecting the at least one <i>ss</i>DNA generated from either the first or the second IIS-restricted <i>ds</i>DNA; and is more preferably based upon the molecular mass of, and/or the nucleotide sequence of, the fragment(s) obtained in the restriction step d), such as a mass spectroscopy technique, in particular of MALDI-TOF; and/or a chromatography technique, such as high pressure liquid chromatography (HPLC); or a suitable combination thereof, such as Gas Chromatography - Mass Spectroscopy (GC-MS).
Nutritional composition of tamarind (<i>Tamarindus indica</i>L.) from the Cerrado of Minas Gerais, Brazil

Abstract – Introduction . The Cerrado is a Brazilian biome that has a large plant heterogeneity. Among the fruit species of the Cerrado, the tamarind stands out due to its economic potential and use in human feeding. Our study evaluated the physical and physicochemical characteristics, and occurrence and content of vitamin C, carotenoids, vitamin E and folates in tamarind (Tamarindus indica L.) from the Cerrado of Minas Gerais, Brazil. Materials and methods . The length, diameter, mass and fruit yield of tamarind were evaluated. Titratable acidity was determined by volumetric neutralization, pH by potentiometry, soluble solids by refractometry, moisture using an oven, ash using a muffle furnace, protein by the micro-Kjeldhal method, total dietary fiber by the gravimetric non-enzymatic method, and lipids with a Soxhlet extractor. Vitamin C and carotenoids were analyzed by HPLC-DAD, and vitamin E and folates by HPLC with fluorescence detection. Results and discussion . Tamarind pulp is composed mainly of carbohydrates (50.07 g·100 g–1) and moisture (35.29 g·100 g–1); it can be considered a good source of dietary fiber (4.13 g·100 g–1). The pH, titratable acidity and soluble solids are 2.95, 18.52 g tartaric acid·100 g–1 and 44.00 °Brix, respectively. Contents of vitamin C (4.79 mg·100 g–1) and folates (59.35 µg·100 g–1) in the tamarind are higher than those observed in traditional fruits. However, the fruit presents low vitamin E content (108.78 µg·100 g–1). Conclusion . The tamarind stands out due to its nutritional value, being a good source of vitamin C and dietary fiber, and an excellent source of folates.
Agri-Tourism and its Internationalization Strategy

Korean competitiveness in rural communities and agriculture has considerably diminished due to the ‘market opening’ for agricultural products: sudden surge of imported agricultural products → oversupply of domestic agricultural products and a fall in their prices → aggravation of farm incomes → weakening of agricultural sector basis. As a result, there is a decline in rural farm income and population. Therefore, the conditions of settling in rural areas have become worse in the chain of vicious circle. As part of an increasing farm diversification to solve the crisis of the Korean agricultural sector, nowadays the agri-tourism attracts considerable public attention.
Immediate and long-term health risks of excessive screen-based media use

Excessive screen-based media use in young people is a clear emerging public health concern which commands serious attention and research to keep pace with the fast and profound changes in technology of screen media and how it is used. The proposed research project’s overarching objective is to investigate the immediate and long-term effects of screen-based media use on a number of important health outcomes in young people. In work package (WP) 1 and WP2 we will investigate the short-term effect of limiting screen use and timing of limiting use on circadian rhythm, sleep, physical activity patterns, and mental stress in 7-year old children and among adolescents/young adults. The WP3 of the proposed project will develop and validate a parent- and self-reported questionnaire to assess time spent (and timing of use) on different forms- and content of today’s screen media among young people and adults. We will introduce these instruments in a number of large-scale population-based cohort-studies. One of the studies will include a large birth-cohort study, which is the basis for the WP4 sub-study. The 7- and 9-year wave of the birth cohort study will provide an ideal context to investigate the long-term influence of exposure to screen-based media on physical fitness, adiposity, glucose metabolism, and mental health in children. The project will integrate multidisciplinary research into the most thorough investigation to date of the plausible short- and long-term effects of screen-based media. Through rigorously conducted randomized crossover experiments and prospective observations in a birth cohort the present project proposal will leverage methodological development of screen use assessment and new technology advancements to assess physical activity patterns, circadian rhythm, sleep, and mental stress in randomly selected young people. The project will break new ground in our understanding of the extent that today’s habitual screen use affects health of young people.
Integrated Programme of Biological and Environmental Monitoring of Spawning and Nursery Grounds of the Main Fisheries Resources, Aimed at Improving Adriatic Fisheries Management

The “NURSERY” program is aimed at constituting and carrying out, on a scientific basis, a multidisciplinary integrated strategy for the
monitoring of the environment as well as of the fisheries resources. Thus, all variables contributing to the “ecosystem equation” will be taken into consideration: from fishing “parameters” (catches and landings by species, fishing fleets, fishing effort including historical data held by the research laboratories of all Adriatic countries), to biological “parameters” (e.g. structure of fish populations, growth of the various fish species), to environmental “parameters” (temperature, salinity, nutrients)
Criação de um centro de I & D para introduzir a inovação dos produtos no setor dos transportes

O principal objetivo do projeto a nível estratégico é aumentar a competitividade da empresa através da obtenção de vantagens tecnológicas. Isso será possível graças ao sem precedentes, no contexto de uma empresa que opera na indústria de estruturas soldadas complexas na Polônia, as despesas com a construção de um centro de pesquisa e desenvolvimento. A este nível, o projeto consiste em construir um edifício, equipando-o com dispositivos e software recém-adquiridos. A realização dos objetivos de investigação exigirá igualmente o recrutamento de pessoal altamente qualificado. O resultado do projeto deve ser entendido como inovações de produtos sob a forma de elementos significativamente melhorados para os meios de transporte. Esta melhoria destina-se principalmente a reduzir o peso, mantendo simultaneamente a resistência necessária, o que no setor dos transportes tem um impacto significativo na redução do consumo de combustível. O que é extremamente importante, o design das peças será otimizado para a possibilidade de produção automática.
Get on top of your multimedia content

The ASSIGN proposal aims to overcome barriers to the recruitment of highly qualified specialists (PhD or equivalent) that cannot be recruited on the national job market, but whose knowledge would be crucial to open up opportunities for innovation and significant growth for the enterprise. With ASSIGN we expected that the Innovation Associate who will be hired will catalyse the radical product innovation of the company’s multimedia content management and publishing platform. The main expertise and skills of the Innovation Associate we expect to source with this recruitment are in the area of semantic multimedia content analysis and indexing, primarily in the domain of image and video and secondary in the domains of text, speech and audio analysis. We foresee a permanent post for the Innovation Associate after the end of the grant and plan to commercialise the innovation developed in the vertical markets of company/enterprise content, team/project content, branding and event content. 
IN2 is very well positioned to supply the Innovation Associate with training in current and trending topics in the area of web software development, that are very much needed in the labour market. With our private cloud and our engagement in application deployment (DevOps) we give to the Innovation Associate additional know-how to advance professionally in areas that can cover the complete software innovation cycle. Moreover, the Innovation Associate will benefit from gaining valuable insights into commercial innovation management and business aspects.
Telemetry operated setting tool

A setting tool for hanging a tubular string includes: a mandrel having an upper portion and a lower portion for extending into the tubular string; a housing connected to the mandrel upper portion; and a bonnet. The bonnet is: for receiving an upper end of the tubular string, disposed along the mandrel, and linked to the housing. The setting tool further includes: an actuator for stroking the bonnet relative to the mandrel and the housing, thereby setting a hanger of the tubular string; an electronics package in communication with the actuator for operating the actuator in response to receiving a command signal; and a latch. The latch is: connected to the mandrel lower portion, operable between an extended position and a retracted position, for being restrained in the retracted position by being disposed in the tubular string, and extendable by being removed from the tubular string.
Neurodidactics of performing arts: the impact of drama teaching on second language acquisition

Since the 1990s, Educational Neuroscience has become an emerging field of research which studies cognitive brain functions (thinking, memory, attention, emotions) and interfaces with the educational environment with the aim of improving teaching and learning. Simultaneously, ""Drama Teaching"", a teaching methodology based on performing arts introduced in the 1970s, is now generating interest, especially in Foreign Language Learning. This research project will investigate aspects of cognition involved in the language learning process and it will analyse how Drama Teaching dynamics can impact language learning and proficiency. In order to define Drama Teaching as a methodology which involves the brain-mind-body dimension and fosters development of the learner as a whole person, a cognitive perspective will be adopted in relation to issues of a) embodied cognition, b) role of emotions in learning, c) impact of context and experience on learning d) cross-cultural identity process, development and awareness. Theoretical scientific investigation will be conducted on cognitive aspects relevant to learning, followed by the study and observation of dramatization practices. Development of curriculum and course implementation will follow. Particular attention will be given to the assessment of learning results and proficiency levels, as well as to the cognitive and emotional factors. The inter-disciplinary perspective adopted by this study is aimed at contributing to the debate on creative, interactive Foreign Language Education taking place in Europe and in the world. The scope is to contribute to the multi-disciplinary inquiries of Educational Neuroscience by elaborating a neuroscientifically grounded theory of Drama Teaching which gives educators guidelines to expand the range of teaching possibilities in accordance with the principles of Learning/Teaching of the “Common European Framework of Reference for Languages”.
The Use of the Cavitation Effect in the Mitigation

Hard mineral scale fouling results in significant economic losses both industrially and domestically. Recently, attempts have been made to use ultrasound to mitigate scale formation and its removal based on the phenomena of cavitation. Cavitation erosion is the removal of material from a solid surface by pressure shock waves associated with the formation and collapse of bubbles. This paper reviews the literature on cavitation erosion of brittle crystalline materials in an attempt to better understand the relationship between the material properties of CaCO3 scale deposits and its potential removal by cavitation. The study finds that from a materials perspective cavitation erosion is intimately associated with both a material’s bulk properties and importantly to its microstructure. The situation is further complicated because the macro and micro-properties of CaCO3 scale are dependent on many factors relating to its depositional environment. The type of scale formed will affect how it is removed by cavitation.
EMPATHY, APPROVAL, AND DISAPPROVAL IN MORAL SENTIMENTALISM

This discussion explores the moral psychology and metaethics of Michael Slote's Moral Sentimentalism. I argue that his account of empathy has an important lacuna, because the sense in which an empathizer feels the same feeling that his target feels requires explanation, and the most promising candidates are unavailable to Slote. I then argue that the (highly original) theory of moral approval and disapproval that Slote develops in his book is implausible, both phenomenologically and for the role it accords to empathy. Finally, I suggest that these problems in moral psychology undermine Slote's metaethical argument for identifying rightness and wrongness with agential warmth and coldness in action.
Family members' reports of the technology use of family members with intellectual and developmental disabilities

A nationwide survey of family members of people with intellectual and developmental disabilities ranging in age from birth through adulthood was conducted to replicate a similar effort by Wehmeyer and update the knowledge base concerning technology use by people with intellectual and developmental disabilities.Survey responses provided information about use of technology for mobility, hearing and vision, communication, independent living, and in the area of computer use. In addition, survey items queried the use of electronic and information technology devices such as use of email, mobile telephones and digital cameras.Survey results showed that although the use of computers for individuals with intellectual and developmental disabilities is more prevalent, other technology use frequency is much the same as in the late 1990s. However, technology needs did vary among school-age individuals over time.Implications of results for technology use of people with disabilities are discussed through the lens of frequency of use and needs for individuals with disabilities.
Formal Properties of ‘Now’

This paper is about the word 'now'. It is closely related to the article Now by professor A. N. Prior (1968). In that article Prior gives an extensive, and undoubtedly correct analysis of the semantical function of the word 'now' in ordinary discourse. This paper gives a short informal discussion of the behaviour of 'now' in English. In this paper, the professor nonetheless consider besides 'now' only operators of a purely temporal nature. The results presented in this paper apply to arbitrary axiom systems. The word 'now' may suggest that, even if the word is not vacuous, its semantical behaviour is too simple to justify a formal analysis. However, it turns out that a proper treatment of 'now' together with the other temporal operators which is not totally trivial, as the semantics developed earlier for these operators cannot be extended in an entirely automatic manner so as to cover 'now'. Keywords:axiom systems; formal properties; now
Modelling for the search for new active materials for redox flow batteries

SONAR will develop a framework for the simulation-based screening of electroactive materials for aqueous and nonaqueous organic redox flow batteries (RFBs). It will adopt a multiscale modelling paradigm, in which simulation methods at different physical scales will be further advanced and linked by combining physics- and data-based modelling. Competing energy storage technologies are only comparable when using the levelized-cost-of-storage (LCOS) as a global metric, accounting for the complex interrelations between factors like CAPEX, lifetime and performance. SONAR will thus develop a screening framework to determine LCOS, starting from the automatic generation of candidate structures for the electroactive material, then iterating through molecular-, electrochemical interface-, porous electrodes-, cell-, stack-, system- and techno-economic-level models. For the iterative traversal of the different scales, exclusion criteria like solubility, standard potentials and kinetics will be defined, and the results for individual candidates will be stored in a database for further processing. To increase the throughput of the screening, SONAR will exploit advanced data integration, analysis and machine-learning techniques, drawing on the growing amount of data produced during the project. The models will be validated e.g. by comparison with measurements of redox potentials for known chemistries, or measurement data of RFB half-cells and lab-sized test cells.
SONAR will work closely with industrial partners (incl. JenaBatteries, Volterion) to ensure the commercial viability of the results. The models will be exploited individually and in a comprehensive screening service offered by Fraunhofer SCAI, facilitating the rapid assessment of the technical and economic potential of a new technology in its earliest development stages. This will reduce the cost and time-to-market, thus strengthening the competitiveness of the EU’s battery industry in the emerging field of organic RFBs.
Aportes a la interculturalidad desde el paradigma de la diversidad: estudio comparativo entre escuelas de España y México

El presente artículo analiza los modelos de gestión de la diversidad cultural a partir de dos estudios de caso en España y México durante el auge de la educación intercultural en la primera década del 2000. Siguiendo a Dietz &amp; Mateos (2011) detectamos tres tipos de paradigmas en la gestión de la diversidad cultural: desigualdad, diferencia y diversidad. El primero de ellos abarca posturas asimilacionistas y segregadoras; el segundo la esencialización de la diferencia y; el tercero lo vinculamos a posturas críticas con la interculturalidad. Nos centramos en un estudio comparativo a partir de la realización de etnografías escolares y comunitarias siendo el eje central dos escuelas, una en Andalucía, España y la otra en Oaxaca, México. Para ello, se realizó el registro de observaciones así como entrevistas semiestructuradas a diferentes actores claves. En los resultados mostraremos cómo los paradigmas de la desigualdad y diferencia son los que sustentaban las políticas educativas así como el discurso de los actores educativos entrevistados. A partir del análisis comparativo de los datos de campo, ofreceremos seis dimensiones de interés analítico como aporte a una interculturalidad crítica configurada precisamente desde el paradigma de la diversidad.