SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
A miniature bio-photonics companion diagnostics platform for reliable cancer diagnosis and treatment monitoring.

Current diagnostic options for cancer treatment monitoring rely on imaging techniques and cannot guarantee proper assessment of therapeutic response. This project aims to develop a disruptive Point of Care (PoC) device for cancer early diagnosis and treatment monitoring as a companion diagnostics tool. One of the scientific breakthroughs of this project is the development of a “cancer stem cells” detection platform by virtue of expression of the cancer stem cell-specific transcription factor TWIST1, which controls the expression of the bloodstream circulating biomarkers POSTN, PCOLCE and TGBI. Cancer stem cells represent the most aggressive/tumorigenic cell compartment within tumors. 
BIOCDx will combine advanced concepts from the photonic, nano-biochemical, micro-fluidic and reader/packaging platforms aiming to overcome limitations related to detection reliability, sensitivity, specificity, compactness and cost issues. BIOCDx will rely on ultrasensitive, photonic elements based on an array of 8 asymmetric MZI waveguides fabricated by TriPlex technology on silicon nitride substrates and will achieve a 100 fold improvement –with respect to current technologies- of sensitivity (<10-8 RIU). BIOCDx will emlploy a smart concept of signal multiplexing for lowering the number of photodetectors required in multi-analyte detection and allowing for a substantial reduction of chip size. A sandwich assay, enhanced with nanoparticles, will be developed, based on the use of two antibodies per protein, to detect all three circulating proteins. This will enhance the limit of detection (LOD) close to femtomolar and the reliability. BIOCDx photonic, nano-biochemical, fluidics and packaging platforms will be integrated into a portable, desktop PoC device. Its validation in preclinical and clinical setting will be performed in three cancer types: breast cancer, hormone-independent prostate cancer and melanoma.
JULIA MARMI — A NOVA PEDRA DA PIASENTINA

NO MUNDO GLOBAL DE HOJE, ACREDITAMOS QUE É NECESSÁRIO LIDAR COM AS MUITAS ALTERNATIVAS POSSÍVEIS NO MERCADO MUNDIAL (ALCANÇÁVEL AGORA COM UM SIMPLES CLIQUE DO RATINHO) INICIANDO UM PROCESSO DE ESPECIALIZAÇÃO DA NOSSA EMPRESA, QUE, EMBORA MUITO ESPECÍFICA E EXCLUSIVA PARA O TIPO DE PRODUTO OFERECIDO (A PEDRA PIASENTINA QUE EXTRAÍMOS E TRABALHAMOS), NOS PERMITE TAMBÉM EXPANDIR AS POSSIBILIDADES DE PRODUÇÃO GRAÇAS A UMA MAIOR EXPERIMENTAÇÃO DE NOVAS TÉCNICAS REALIZADAS
Network of Technology Transfer Nodes for Enhanced open Innovation in the Central Europe advanced manufacturing and processing industry

EU most important automation & mechatronic industries are in CE regions: business dimension is intercontinental but the services to kick innovation are still local & this slows quick canalization of R&D results from EU & CE labs into the industrial system. This makes tech-transfer & brokerage commissioned by companies long, expensive, often duplicate efforts & do not respond to the time-to-market requirements. The challenge is increasing & federating these services to accelerate the transposition of KET from EU-funded research & CE labs in new end-users components & apps for CE advanced manufacturing industries.
NUCLEI main objective is to change the obsolete innovation management model from a “local-based” technology scouting approach to a transnational pool of knowledge supporting advanced manufacturing innovation beyond regional borders. This increases economic interdependences among seven S3-manufacturing Regions & encourages more effective transnational value chains in automotive, electrical industry, IT sector, robotic & mechanic automation. Such joint knowledge sourcing approach helps 7 NUCLEi industrial clusters & its end-beneficiaries (Corporations, SMEs, R&D performers) to foster process of emergence of new consortia/business deals for execution of bold technological, product, market projects.
The creation of 1 broad&collaborative environment, initially tested by 100 testimonial companies from 7 CE Regions,  is expected to increase linkages with innovators outside own regions by 40-50%, accelerate the time-to-market of R&D concepts (from EU-funded research &CE laboratories to companies) by 15-20%, increase R&D expenditure & patent applications by 2-3% of mid-term turnover. Drivers to run innovation are 1 joint cloud based on FoF-IMPACT&COFACTOR H2020 projects, 3 pilots (tech-brokerage; knowledge transformation; mechatronic standardization) & 1 Business Innovation Strategy to expand NUCLEi i-services within each regional S3 as driving force
Know about biodiversity and ecosystems to better protect them together

"This project is part of the plan BIODIVALP": This project aims at improving the knowledge on biodiversity and Alpine ecosystems in a cross-border context. The achievement of this goal revolves around the co-construction of a common list of fauna and floristic species and sharing the methods for monitoring, for inventory and evaluation process of the NATURA 2000 sites. This will enable the establishment of common work tools and shared action plans. Furthermore, the cross-border value of the project regarding the PITEM BIODIVALP is undeniable since these tools will be used for the other projects.

The Western Alps Massif is the biogeographic and transboundary link of the ALCOTRA program. It rubs shoulders with both the summits and the Mediterranean basin forming a hotspot of biodiversity. Nevertheless, this exceptional natural heritage is vulnerable to the erosion of biodiversity and to global changes (fragmentation of environments, climate change, etc.). Based on this observation, a consultation process between the 5 Regions and the territorial actors has made it possible to draw up a framework ambition aimed at protecting and enhancing biodiversity and Alpine ecosystems through a partnership and a network of cross-border ecological connectivities. This ambition is articulated in two strategic objectives, contributing to the EUSALP strategy and the Alpine Convention, and aiming to (i) stem the erosion of ecosystems and protected species and (ii) enhance the attractiveness of the cross-border territory. The originality of the activities concerns the cross-border structuring of an integrated governance, the knowledge and the methodologies of management of biodiversity reservoirs, a public policy of ecological connectivities and a strategy of valorization of the biodiversity. In addition, the activities provide for the capitalization of various European projects (see point 5). The French and Italian partners of the plan include protected areas, communities, associations and chambers of commerce.
Fraud and Job Satisfaction amongst Nigerian Bank Managers

This quantitative, causal-comparative study examined the relationship between job satisfaction and bank managers’ predisposition to fraud and forgery from three banks of different consolidation status in two Nigerian cities, Lagos and Abuja. Data were collected from 302 bank managers using the Job Satisfaction Survey and Work Locus of Control Survey. Results from a Pearson product–moment correlation (r) analysis suggest each of the job satisfaction variables had a significant and negative relationship with fraud tendency, a proxy for distress, with the exception of operational conditions. Ordinary least squares multiple regressions predicted a negative and significant relationship between job satisfaction and fraud disposition between male and female bank managers as well as between banks of different consolidation status, and revealed that some satisfaction measures, such as promotion and communication, had a reduction impact on fraud in some banks.
Knowing what would happen: The epistemic strategies in Galileo's thought experiments

While philosophers have subjected Galileo's classic thought experiments to critical analysis, they have tended to largely ignored the historical and intellectual context in which they were deployed, and the specific role they played in Galileo's overall vision of science. In this paper I investigate Galileo's use of thought experiments, by focusing on the epistemic and rhetorical strategies that he employed in attempting to answer the question of how one can know what would happen in an imaginary scenario. Here I argue we can find three different answers to this question in Galileo later dialogues, which reflect the changing meanings of 'experience' and 'knowledge' (scientia) in the early modern period. Once we recognise that Galileo's thought experiments sometimes drew on the power of memory and the explicit appeal to 'common experience', while at other times, they took the form of demonstrative arguments intended to have the status of necessary truths; and on still other occasions, they were extrapolations, or probable guesses, drawn from a carefully planned series of controlled experiments, it becomes evident that no single account of the epistemological relationship between thought experiment, experience and experiment can adequately capture the epistemic variety we find Galileo's use of imaginary scenarios. To this extent, we cannot neatly classify Galileo's use of thought experiments as either 'medieval' or 'early modern', but we should see them as indicative of the complex epistemological transformations of the early seventeenth century.
Unraveling molecular quantum dynamics with accelerated ab initio algorithms

Many physical and chemical processes in nature as well as an increasing number of man-made devices exploit the quantum properties of electrons, nuclei, and the quantum signatures of the coupling between nuclear and electronic motions. To optimize the design of novel devices and to correctly interpret physical processes studied, e.g., by experiments probing the molecular dynamics induced by interactions with ultrafast laser pulses, quantitative simulations are required. Although ninety years have passed since the discovery of Schrödinger’s equation, these simulations remain extremely difficult for systems with more than a few degrees of freedom.  While some physicists are satisfied with a theoretical model that describes the system qualitatively, in chemistry the promising term ``ab initio quantum molecular dynamics'' is frequently misused for methods treating nuclear motion classically and using quantum mechanics only for electrons. The first goal of this project is, therefore, to bridge these two philosophies and combine accurate ab initio electronic structure calculations with accurate quantum or semiclassical treatment of the nuclear dynamics.  Since the exact solution of time-dependent Schrödinger’s equation scales exponentially with the number of atoms, accelerating computers even by orders of magnitude will not break the exponential barrier to simulating molecular quantum dynamics. The second goal of this project is, therefore, developing and implementing both exact and approximate computationally efficient quantum dynamics methods applicable to polyatomic molecules. The last goal of the project is developing systematic methods for interpreting spectra of complex systems in terms of the underlying nuclear and electronic dynamics. To summarize in simple terms, the ultimate objective is developing theoretical methods that will allow replacing the popular classical molecular dynamics movies by their quantum analogs.
Free Speech and Political Legitimacy: A Response to Ed Baker

Normative discussion too often suffers from lack of agreement on criteria by which to judge the merits of the various contending theories. Bereft of such common ground normative debate often has the deep subjectivity—and hence the productivity—of schoolyard boasts about whose dog is best. I was therefore delighted to discover that the normative essence of the autonomy-based theory of free speech that Ed Baker proposes in this Symposium is political legitimacy, the same basic norm underlying the somewhat different visions of participatory democracy that Robert Post and I defend in a related symposium as the best explanation of the American free speech principle. Having identified this common ground, I will in Part I of this response attempt to show that there is a firmer connection between legitimacy and participatory democracy than there is between legitimacy and the autonomy theory that Ed proposes. Part II responds to certain of Ed’s claims about the fit between his theory and current free speech doctrine. Part III concludes this response with a short discussion of why overall doctrinal fit matters in determining the best theory of the First Amendment.
METHODS FOR EMITTING AND REFILLS FOR HOLDING TWO OR MORE COMPOSITIONS

A refill for holding at least two compositions comprises a container including a body and first and second compositions disposed within the body such that the first and second compositions are substantially separated and the second composition is disposed above the first composition. The refill further includes a tube disposed within the body of the container such that the tube contains the first and second compositions, wherein the tube has an inner diameter and an outer diameter. Still further, the refill includes a wick disposed within the tube, wherein the wick contains the first and second compositions and has a diameter that is smaller than the inner diameter of the tube to create a gap between the wick and the tube is smaller than the inner diameter of the tube to create a gap between the wick and the tube.
Social support and self-management capabilities in diabetes patients: An international observational study

The objective of this study was to explore which aspects of social networks are related to self-management capabilities and if these networks have the potential to reduce the adverse health effects of deprivation.In a cross-sectional study we recruited type 2 diabetes patients in six European countries. Data on self-management capabilities was gathered through written questionnaires and data on social networks characteristics and social support through subsequent personal/telephone interviews. We used regression modelling to assess the effect of social support and education on self-management capabilities.In total 1692 respondents completed the questionnaire and the interview. Extensive informational networks, emotional networks, and attendance of community organisations were linked to better self-management capabilities. The association of self-management capabilities with informational support was especially strong in the low education group, whereas the association with emotional support was stronger in the high education group.Some of the social network characteristics showed a positive relation to self-management capabilities. The effect of informational support was strongest in low education populations and may therefore provide a possibility to reduce the adverse impact of low education on self-management capabilities.Self-management support interventions that take informational support in patients' networks into account may be most effective, especially in deprived populations.
RESONATOR SYSTEM FOR A SPEAKER OF AN ELECTRONIC DEVICE

A resonator for a transducer of an electronic device is provided. The resonator comprises: a first enclosure having a first opening to receive a back end of the transducer and a second opening; and a port connected to the first enclosure through the second opening of the enclosure, the port having a first end, a second end, an interior channel spanning from the first end to the second end. When the transducer is mounted into the first enclosure, a first volume between the transducer and the enclosure is formed which is in communication with air surrounding the second end of the port through the interior channel of the port. A second enclosure to cover a front portion of the transducer may be provided.
Personalized Tag Recommendation through Nonlinear Tensor Factorization Using Gaussian Kernel

Personalized tag recommendation systems recommend a list of tags to a user when he is about to annotate an item. It exploits the individual preference and the characteristic of the items. Tensor factorization tech- niques have been applied to many applications, such as tag recommendation. Models based on Tucker Decomposition can achieve good performance but require a lot of computation power. On the other hand, mod- els based on Canonical Decomposition can run in linear time and are more feasible for online recommendation. In this paper, we propose a novel method for personalized tag recommendation, which can be considered as a nonlinear extension of Canonical Decomposition. Different from linear tensor factorization, we exploit Gaussian radial basis function to increase the model’s capacity. The experimental results show that our proposed method outperforms the state-of-the-art methods for tag recommendation on real datasets and perform well even with a small number of features, which verifies that our models can make better use of features.
Assurance and certification in secure multi-party open software and services.

Continuous, distributed changes rule today's European Digital Single Market as no single company does master its own national, in-house software. Software is mostly assembled from “the internet” and more than half come from Open Source Software repositories (some in Europe, most elsewhere). Security & privacy assurance, verification and process certification techniques designed for large, controlled updates over months or years, must now cope with small, continuous changes in weeks, happening in sub-components and decided by third party developers one did not even know they existed.
AssureMOSS addresses these challenges to the fullest extent: « Open Source Software - Designed Everywhere, Secured in Europe ».
AssureMOSS proposes to switch from process-based to an artefact-based security evaluation by supporting all phases of the continuous software lifecycle (Design, Develop, Deploy, Evaluate and back) their artefacts (Models, Source code, Container images, Services). The key idea is to support mechanisms for lightweigth and scalable screenings applicable automatically to the entire population  of software components by
- Machine intelligent identification of security issues across artifacts,
- Sound analysis and verification of changes by tracing the security and privay side effects,
- Business insight by risk analysis and security evaluation.
This approach supports fast-paced development of better software by a new notion: continuous (re)certification.
AssureMOSS has assembled a team including 5 leading Universities (Delft, Gotheborg, Trento, Vienna, VU Amsterdam), 3 innovative SMEs (FrontEndART, Search-Lab, Pluribus One), 3 Large Enterprises (E&Y, SAP, Thales) and 1 Special Interest Group Organization (EU-VRi) and an Advisory Board with key figures from OSS and industry at large.
The project will generate not only a set of innovative methods and open source tools but also benchmark datasets with thousands of vulnerabilities and code that can be used by other researchers.
AWNING

An awning includes a base part, which can be attached to a building part, a fabric shaft, which can be rotatably driven thereon by means of a motor, an awning fabric, which can be retracted and extended and wound onto the fabric shaft and unwound therefrom, and a noise influencing system, which has a controller and at least one sound actuator activated thereby and coupled to an awning component, the at least one sound actuator producing a counter-sound pattern adapted to the sound pattern during the retraction and/or extension of the awning for influencing the noise, in particular noise and vibration damping.
Trabalho em equipe na estratégia saúde da família: uma revisão integrativa

No Brasil, o trabalho em equipe é visto como a principal estratégia de sucesso da Atenção Primária de Saúde (APS), sendo presumido pelo Ministério da Saúde. Sendo assim, ao decorrer dos anos ocorreu uma forte expansão da APS por intermédio da Estratégia de Saúde da Família (ESF), sendo uma revolução da APS, tendo como base o trabalho em equipe um dos pressupostos mais importantes para a readaptação do método de trabalho. A revisão é composta por cinco etapas: identificação do problema, busca na literatura, avaliação dos dados, análise dos dados e apresentação da revisão. Os estudos encontrados foram publicados nos anos de 2018 a 2021 sendo o equivalente de 12,5% no ano de 2018, 50% no ano de 2019, 12,5% no ano de 2020 e cerca de 25% no ano de 2021. Diante disso, a os trabalhos eram 100% do Brasil. Dessa maneira, os conteúdos das pesquisas encontradas referiam-se sobre trabalho em equipe na Estratégia Saúde da Família.
Identification of dna-protein-crosslink repair factors

DNA damage can cause mutations and genome instability and is therefore the underlying cause of many pathologies including neurodegeneration and cancer. To maintain genome integrity, cells are equipped with sophisticated pathways for efficient repair of the broad spectrum of lesions that frequently arise in cellular DNA. By now, most DNA repair pathways are well understood. However, dedicated mechanisms for the repair of DNA-protein crosslinks (DPCs) have only been discovered very recently and are still poorly described. This is mainly due to a lack of approaches for specifically generating DPCs. My host lab has established a cell-based system that facilitates, for the first time, the induction of genome-wide yet defined DPCs. With this system at hand, I propose a project to identify and characterise cellular responses to DPCs in both human cells and in the nematode Caenorhabditis elegans (C. elegans). I will utilize the newly established system in a CRISPR/Cas9-based genome-wide screen to identify new DPC repair factors, and subsequently characterise their roles in promoting genome stability. I will strengthen the physiological relevance of my findings by studying orthologues of selected factors in C. elegans, in order to gain insights into their tissue specificity and roles in development and organismal fitness. By combining the host lab’s strong standing within the DNA repair field and formidable know-how in the area of cell-based studies of DNA damage repair pathways with my expertise in DNA damage research in C. elegans, I will be in a unique position to critically advance our knowlegde about DPC repair. Considering that DPCs are generated by many anti-cancer drugs, it is particularly important to illuminate the underlying repair mechanisms to improve current treatment strategies. This timely and interdisciplinary project will greatly enhance my scientific and transferrable skills required to realize my long-term goal of becoming an independent group leader.
OFF-GRID PHOTOVOLTAIC APPLICATIONS IN REGIONS OF LOW ELECTRIFICATION: HIGH DEMAND, FAST FINANCIAL AMORTIZATION AND LARGE MARKET POTENTIAL

People in rural regions of various developing countries suffer on having no access to modern forms of energy, in particular electricity. This work is focussed on regions inhabited by these people and presents insights on the short financial amortization periods of solar home systems and photovoltaic pico systems. With amortization periods of about 6 to 18 months, pico systems represent a capitalized value of about 10 to 45 times the original capital expenditures at the point of full financial amortization. For a significantly higher electricity demand hybrid PV minigrids might be an excellent solution for rural electrification. However the economics are still a challenge. Based on excellent economics of small PV applications the total global residential small PV market potential is estimated to about 8 GWp and 80 bn€. The total PV-based off-grid market potential for the not yet electrified people might be estimated to about 70 GW and roughly 750 bn€.