SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Dissecting and targeting senescence programs to advance hematopoietic stem cell-based gene therapies

The success of Hematopoietic Stem and Progenitor Cell (HSPC) gene therapies critically depends on the capacity to genetically engineer HSPCs without compromising their functional properties. Emerging evidence, including our own, indicates that HSPC exposure to currently available gene transfer and gene editing technologies –which require prolonged ex-vivo culture, high viral vector doses and nuclease-induced DNA double strand breaks– unexpectedly converge on the DNA damage response (DDR), a signaling cascade leading to cell cycle arrest. Protracted DDR impairs the hematopoietic reconstitution of gene-modified cells upon transplantation; instead, its transient inhibition significantly improves their functionality. This experimental evidence uncovers a previously unappreciated interplay between viral vector sensing and the host cell DDR machinery in human HSPCs. Yet, we have just scratched the surface of a plethora of still unexplored cellular programs potentially hampering the clonal composition and the dynamics of reconstitution upon transplantation of this primitive cell compartment. This proposal builds on the innovative concept that current gene engineering protocols may inadvertently trigger the activation of a cellular senescence program in HSPCs with both cell-autonomous and paracrine short- and long-term consequences on engineered human hematopoiesis. By employing quantitative imaging and cutting-edge genomic technologies and taking advantage of uniquely available gene therapy platforms and primary patient samples, we will identify the molecular determinants that promote senescence in HSPCs and design innovative hypothesis-driven strategies to mitigate senescence barriers for more effective, safer and clinically broader gene therapy applications. Successful completion of the project will unveil a new set of mechanisms controlling the biology of gene-engineered HSPCs and open novel scientific horizons for the development of innovative gene and cell therapies.
The value creation scale of supplier-distributor relationship in international markets

Purpose – The purpose of this study is to develop a value-creation measurement which is applicable to the supplier–overseas distributor relationship. As cross-border cooperation is increasingly important, there is yet no appropriate scale to measure the relationship value between the supplier and the distributor in cross-boundary context. Design/methodology/approach – With a view to establishing the measurement scale for the relationship value created between manufacturer and its overseas distributor, this study uses exploratory factor analysis, confirmatory factor analysis (CFA) and regression to test reliability, convergent validity, discriminant validity and nomological validity of the scale. Findings – The scale is made up of six factors, including “customer service”, “relationship interaction”, “cost reduction”, “product promotion”, “product sales” and “information offering”; subsequent statistical tests strongly support the measurement. Research limitations/implications – First, the sample collection was not conducted randomly, and the sample was limited to 190 valid questionnaires. Future research might be conducted randomly or in a longitudinal fashion to increase the sample size. Second, this study focuses mainly on manufacturers in the mechanical parts industry and was conducted unilaterally to discuss the creation of relationship value. It is suggested that future researchers investigate relationship value generated in cross-border cooperation from a bilateral perspective or discuss cooperative relationships in other industries. Practical implications – This study creates a functional scale to measure the supplier–distributor value creation in cross-border cooperation, and it proves that six factors pertaining to relationship value have significant positive correlation with operating performance; in this regard, in supplier–distributor cooperative relationship, more value the distributor creates for its supplier, the better the operating performance of the supplier will be. Originality/value – In the academic sense, this measurement will be of substantial help to future empirical research on a larger scale. When applied to practice, this measurement supplements the extant body of value-measuring tools and works as an evaluation index for choosing overseas distributor.
Accelerating research & development for advanced therapies

Major current hurdles for wide clinical use of AAV vectors are attributable primarily to: (i) host elimination by both immune and non-immune sequestering mechanisms – such neutralization by host antibody responses critically limits the possibility of repeated AAV delivery; (ii) AAVs are prevalent in the environment and hence a large proportion of the population carry AAV antibodies (up to 80%)– this pre-existing immunity renders AAV unable to infect target cells forcing substantial patient cohorts to be excluded from clinical trials. 
The current proposal is founded on compelling track record in the field and brings together a ‘best-with-best’ multidisciplinary team of international leading academic and EFPIA partners with complimentary expertise in gene therapy, immunology, chemistry, engineering, biotechnology, drug safety, viral vector production, regulatory and clinical trials. The overall goal is to analyse the currently available clinical data and then design preclinical and clinical studies to fill the knowledge gaps in advanced therapies development. Our main aims are to: 1) Develop improved model systems for predicting product immunogenicity in humans. This will be achieved by generating human and NHP 3D hepatic models; 2) Enhance our understanding of gene/cell therapy drug metabolism inside a host of cell types. The plan is to define metabolism of the therapeutic vector genome in different cell types to understand whether rates of degradation, episomal maintenance, or integration, and metabolic stress induced by AAV vector transgene expression vary from cell to cell. We will then adopt strategies to mitigate the loss of vector genomes and improve persistence; 3) Use diverse clinical expertise to establish the clinical factors around pre-existing immunity limiting patient access to advanced therapies therapy; 4) Engage regulators to ensure that the concepts and the data generated through this IMI programme will fill the gaps and support furture trials.
Time-of-flight patterns of ultracold bosons in optical lattices in various Abelian artificial magnetic field gauges

We calculate the time-of-flight patterns of strongly interacting bosons confined in two-dimensional square lattice in the presence of an artificial magnetic field using quantum rotor model that is inherently combined with the Bogolyubov approach. We consider various geometries of the magnetic flux, which are expected to be realizable, or have already been implemented in experimental settings. The flexibility of the method let us to study cases of the artificial magnetic field being uniform, staggered or forming a checkerboard configuration. Effects of additional temporal modulation of the optical potential that results from application of Raman lasers driving particle transitions between lattice sites are also included. The presented time-of-flight patterns may serve as a verification of chosen gauge in experiments, but also provide important hints on unconventional, non-zero momentum condensates, or possibility of observing graphene-like physics resulting from occurrence of Dirac cones in artificial magnetic fields in systems of ultra-cold bosons in optical lattices. Also, we elucidate on differences between effects of magnetic field in solids and the artificial magnetic field in optical lattices, which can be controlled on much higher level leading to effects not possible in condensed matter physics.
Evolution of the interaction between mitochondrial and nuclear genomes in bumblebees (hymenoptera, apidae, bombus): the importance of numts and heteroplasmy

Cutting edge sequencing technology enables, for the first time, the characterization of high quality numts (non-functional copies of genes of mitochondrial origin present in the nuclear genome) and heteroplasmy (the presence of different mitochondrial genotypes in the same organism). Although they are completely distinct molecular phenomena, both can be at the same time obstacles and new tools for evolutionary studies. EVOBOMICS is three projects in one, in which numts, heteroplasmy and genomes (nuclear and mitochondrial) will be studied at the same time and from an evolutionary perspective. The following hypotheses will be tested: i) Numts and heteroplasmy are common in a target model taxon (bumblebees); ii) The number of numts in any given species will increase/decrease proportionately with its nuclear genome size; iii) Ancestral numts are related to speciation events, and thus provide a novel tool for constructing and investigating phylogenies; iv) Numts can be used as molecular marker for phylogenomic reconstruction as truly RGCs (rare genomic changes); v) Heteroplasmy is not a temporary state and is shared among close related species; vi) Heteroplasmy can interfere in species delimitation and is related to speciation events. 
My previous experience and preliminary results ensure the feasibility of EVOBOMICS. During my PhD in Brazil, I initiated an unprecedented and unique research programme into the evolution of mitochondrial genomes, with a focus on numts and heteroplasmy in bees. So far, five articles have been published. Together, these studies suggest that numts and heteroplasmy are common phenomena in bees, and this is likely to be representative of many other taxa. These studies had to be interrupted due to motherhood, but now, EVOBOMICS will give me the opportunity to develop this new research area using innovative methodological approaches, and to update and improve my skills, providing a key stepping stone for my career in Evolutionary Biology.
A Study on Korean Jacket Style Expressed in Modern Fashion

This study researches the form of the Korean jacket point through relics from the Three Kingdoms period that have the traditional Korean style and grace of the Goryeo period as well as the form of the modern Korean jacket starting point. Several conclusions can be drawn from the Korean Image of the Korean jacket that can be classified into types expressed in the jacket style of modern fashion. Therefore, we will analyze traditional elements of Korean beauty through the "Korean image" on how to express it in modern fashion. The purpose of this study is to understand modern design creation and Korean culture. It is important to begin the world through the application of traditional elements to recognize Korean beauty as well as to utilize historical dress based on function and popularity to continue the effort.
Identification of potential probiotic Lactobacillus plantarum isolates with broad-spectrum antibacterialactivity

Food deterioration is largely related to contamination by undesirable microorganisms; it can cause economical loss and serious health-related problems. Owing to increased awareness of health issues by consumers, biological food preservation using antibacterial Lactobacillus species is being increasingly studied. Here, we make a preliminarily assessment of the antibacterial activity of 347 Lactobacillus plantarum isolates against five common food-borne pathogens (Escherichia coli, Staphylococcus aureus, Listeria monocytogenes, Salmonella typhimurium, and Shigella flexneri). Nine of these isolates had broad-spectrum antibacterial activity and were selected for further experimentation. Subsequent assays based on physical, chemical, and sensory evaluations of yoghurts fermented in the presence or absence of each of the selected isolates and persistence of antibacterial activity following protease challenge revealed that L. plantarum isolate IMAU10216 was superior to the other isolates. L. plantarum IMAU10216 also exhibited high in vitro gastrointestinal tract tolerance. To conclude, we have identified a novel bioactive antibacterial L. plantarum isolate with potential for use as a probiotic in the production of fermented milk or other related dairy products. Further in vivo studies are now required.
SU-E-T-217: Automated Data Mining of Lung SBRT Cases for Predicting Dosimetric Indices in Prospective Plans

To develop an automated technique for evaluating lung stereotactic body radiotherapy (SBRT) plan quality and predicting achievable lung dose constraints.We examined the workflow scripting capabilities of a radiation oncology software package (MIM Software Inc) for automatically generating mean dose gradients and overlap volume histograms (OVHs) for lung SBRT plans. Mean dose gradients were created to assess plan quality by quantifying the dose fall-off from the planning target volume (PTV) into the ipsilateral lung. OVHs were created to evaluate potential predictors of achievable lung dose constraints by measuring the amount of ipsilateral lung volume overlapping the uniformly expanded PTV. Based on the knowledge that OVHs will depend on the size and spatial relationship of the lung and PTV structures, we hypothesize that OVH-derived indices will therefore serve as predictors of achievable lung dose. The workflow scripts were evaluated in a pilot study of 10 lung SBRT plans (50 Gy in 5 fractions) with varying PTV sizes and locations.The scripted workflows were successful in automatically generating mean dose gradients and OVHs for the PTV and ipsilateral lung. The workflows were able to produce the aforementioned data in a matter of seconds (per patient), which would have otherwise been excessively time consuming and labor intensive. From the pilot study, the average mean dose gradient was - 4.1 ± 0.6, indicating that all evaluated patients had similar and acceptable plan quality. Furthermore, the OVH data indicated that a 0 mm PTV expansion and a 10 mm PTV expansion correlated with the mean lung dose (correlation coefficients of 0.71 and 0.56, respectively).Our current data demonstrate that mean lung dose correlates to multiple OVH indices. These results indicate that automated large-scale mining of retrospective data is a highly promising approach for predicting dosimetric indices in prospective lung SBRT plans.
DRYING SYSTEM

Disclosed is a system (1) in a machine for producing a paper web, cardboard web, tissue web, or another fiber web (2) with a predrying zone and/or at least one drying zone. According to the invention, at least one heated drying cylinder (3, 10) over which the fiber web (2) is guided along with at least one wire (5) and an impermeable covering (14), is disposed upstream of, within, or downstream of the predrying zone, or upstream of, within, or downstream of the drying zone. Said at least one drying cylinder (3, 10) is covered, across a section of the outer circumference thereof, by at least one pressing hood (4, 11) which applies a certain contact pressure to the drying cylinder (3, 10).
Smart tall buildings by using piezoelectricity in joints

The SMART-UP project will initiate innovative devices called piezoelectric-dampers (PiDs) to be embedded in modern tall buildings for simultaneous structural elements connection and energy harvesting (EH). PiDs are composite elements (piezoelectric+steel or rubber) located in the connections between buildings’ structural members and engaged by wind-induced oscillations to transform the kinetic energy of the oscillating structure into electricity. The concept of PiD is transformative as this will scale-up currently developed piezoelectric EH (pzEH) techniques at the micro and meso-scales to the truly macro scale. pzEH devices have never been implemented as structural connections in civil buildings for a number of reasons, such as the inadequacy of piezo materials in carrying loads and low frequencies of the vibrations occurring in buildings. These will be comprehensively addressed in SMART-UP by innovative in-parallel coupling schemes between piezo and the load-carrying members such as steel and/or rubber and by allowing the piezo-blocks working in nonlinear regimes arising from buckling or impact. These features will allow their implementation in buildings for powering wireless sensors provided for building automation, which leads to an increment of the building sustainability, and for structural-health monitoring, leading to an increase of the building resilience. Thanks to the introduction of these novel macroscale EH skills, the SMART-UP project makes a step-change in high-rise buildings design and management, by defining a new breed of tall SMART buildings with self-powering, adaptive-in-behavior capabilities. The envisioned buildings not only resist wind loads, but they exploit wind-induced vibrations to reduce their carbon footprint and improve their performances. They will push Europe moving forward to the smart cities era, which is of paramount importance in our modern technological and connected/inclusive society.
Convective Generation of Equatorial Superrotation in Planetary Atmospheres

Abstract In rapidly rotating planetary atmospheres that are heated from below, equatorial superrotation can occur through convective generation of equatorial Rossby waves. If the heating from below is sufficiently strong that convection penetrates into the upper troposphere, then the convection generates equatorial Rossby waves, which can induce the equatorward angular momentum transport necessary for superrotation. This paper investigates the conditions under which the convective generation of equatorial Rossby waves and their angular momentum transport lead to superrotation. It also addresses how the strength and width of superrotating equatorial jets are controlled. In simulations with an idealized general circulation model (GCM), the relative roles of baroclinicity, heating from below, and bottom drag are explored systematically. Equatorial superrotation generally occurs when the heating from below is sufficiently strong. However, the threshold heating at which the transition to superrotation occurs increases as the baroclinicity or the bottom drag increases. The greater the baroclinicity is, the stronger the angular momentum transport out of low latitudes by baroclinic eddies of extratropical origin. This competes with the angular momentum transport toward the equator by convectively generated Rossby waves and thus can inhibit a transition to superrotation. Equatorial bottom drag damps both the mean zonal flow and convectively generated Rossby waves, weakening the equatorward angular momentum transport as the drag increases; this can also inhibit a transition to superrotation. The strength of superrotating equatorial jets scales approximately with the square of their width. When they are sufficiently strong, their width, in turn, scales with the equatorial Rossby radius and thus depends on the thermal stratification of the equatorial atmosphere. The results have broad implications for planetary atmospheres, particularly for how superrotation can be generated in giant planet atmospheres and in terrestrial atmospheres in warm climates.
Should we treat uncomplicated symptomatic diverticular disease with fibre?

Diverticular disease is a common gastrointestinal condition in older age groups. The prevalence is increasing with the ageing of our population, and diverticular disease in younger age groups also seems to be increasing.1 Among those affected, 10-25% will develop symptoms.2 Although diverticular disease and irritable bowel syndrome share the symptoms of pain and variable bowel habit, the proportion of cases of diverticular disease that meet strict criteria for irritable bowel syndrome varies from 14% to 51%,3 4 the lower figure being no different from the incidence in those with no diverticulosis. NHS patient information websites and leaflets and the standards committee of the American Society of Colon and Rectal Surgeons recommend fibre for recurrent, short lived, non-inflammatory abdominal pain and for preventing diverticulitis; the standards committee estimates the success of fibre in preventing recurrence of diverticulitis as >70%. 

However, although low intake of fibre is associated epidemiologically with an increased risk of developing diverticulosis, the recommendations for fibre as a treatment are based on weak evidence that is old, largely observational, and uncontrolled.2 5 Although Painter’s case series of 70 patients with diverticular disease who took two teaspoons of bran three times a day showed excellent resolution of symptoms, it lacked any control and so is unconvincing.6 There is also no good evidence for the amount or type of dietary fibre needed, and clinical experience suggests that bran fibre and green vegetables may worsen symptoms in some patients. This fits with data from randomised controlled trials in irritable bowel syndrome showing that bran increases flatulence7 and may well do the same in diverticular disease. Another randomised controlled …
Research on the Factors of Development of Noninterest Activities of Chinese Commercial Banks——Based on the Panel Data Before and After Crisis of 13 Listed Banks

This paper selects panel data from 2002to 2011of 13China's listed commercial banks.It establishes fixed-effects cross-sectional model to analyze the development of noninterest income of China's commercial banks.It identifies the external and internal factors of noninterest income.Furthermore,it explores the effect of the financial crisis in 2008on the development of noninterest income of China's commercial banks in the future.Results indicate that the scale expansion of the banks,the scale expansion of non-bank financial institutions and the increase of social financing management need have significant effects on noninterest activities' development,respectively;while,the rise of return on asset,the increase of loan to deposit ratio and the scale expansion of foreign banks have negative effects on noninterest activities' development.In addition,the financial crisis pushed Chinese banks to exert stricter regulations on the development of noninterest activities.
An eco-friendly and sustainable sewage sludge valorization unit

TreaTech, a young clean-tech Swiss company, has developed an innovative technology that will revolutionise the waste management of sewage sludge by turning it into valuable by-products and energy such as biogas, clean water and natural fertilizers that would otherwise be lost during disposal process. 
Contrary to other solutions that rely on incineration or landfilling, which are expensive for companies and harmful for the environment, TreaTech has developed a treatment unit KATEDRAL that can operate with the vast majority of liquid waste streams, and contribute to provide a cost-efficient, ecological and reliable disposal solution. Our mobile  unit KATEDRAL will offer a solution 40% cheaper than incineration since it does not require transport of the material nor fossil energy for incineration and will reduce more than 60% of today’s GHG emissions since organic compounds present in the sludge are not burnt anymore, but transformed into valuable renewable energy (biogas).