SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
The early lithic productions of Island Southeast Asia: Traditions or convergences?

Island Southeast Asia has been the subject of intense prehistoric investigations since the seminal work of Eugene Dubois in the late XIXth century. This has resulted in several discoveries of a very diverse type of lithic productions of oftentimes debated age. Recent and old excavations have now secured the production of stone artefacts as early as 1 million years on Flores Island, 800,000 years on Java Island, 700,000 on Luzon Island and at least 118,000 years on Sulawesi Island. Along with these findings, several surface collections which most certainly date back to the Lower Palaeolithic are known, and adds to the diversity of the lithic productions. In this paper, we report what is at stake regarding our current knowledge over the early lithic productions of Island Southeast Asia, without giving more importance to one type of artefact over another. After describing the findings from each islands taken one by one, we compare the similarities and dissimilarities between these sometimes isolated and sometimes connected geographic entities. It appears that each of these islands might have had its own evolutionary trend with its own rhythm. L’Asie du Sud-Est insulaire a fait l’objet d’intenses recherches sur sa préhistoire depuis les travaux précurseurs d’Eugène Dubois à la fin du XIXe siècle. Cela a donné lieu à plusieurs découvertes de productions lithiques très diversifiées d’âge souvent discuté. Des fouilles récentes et anciennes ont permis de confirmer la production d’artefacts en pierre datant d’un million d’années sur l’île de Flores, de 800 000 ans sur l’île de Java, de 700 000 ans sur l’île de Luzon et d’au moins 118 000 ans sur l’île de Sulawesi. Parallèlement à ces découvertes, plusieurs collections de surface datant très certainement du Paléolithique inférieur sont connues, ce qui ajoute à la diversité des productions lithiques. Dans cet article, nous rapportons les éléments de notre connaissance actuelle sur les productions lithiques anciennes de l’Asie du Sud-Est insulaire, sans donner plus d’importance à un type d’artefact plutôt qu’à un autre. Après avoir décrit les résultats obtenus sur chaque île prise une à une, nous comparons les similitudes et les dissemblances entre ces entités géographiques parfois isolées et parfois reliées. Il apparaît que chacune de ces îles a pu avoir sa propre tendance évolutive avec son propre rythme.
Toward “Harder” Medical Humanities: Moving Beyond the “Two Cultures” Dichotomy

Using the current international debate surrounding the incorporation of medical humanities into medical curricula as a starting point, the authors address both the legitimacy and didactics of teaching medical humanities to medical students. They highlight the paradox of the increasing prevalence of medical humanities in medical curricula and the often critical reception humanities courses receive. The alleged lack of empirical evidence linking such courses with improved patient care cannot alone explain the criticism they engender. After a short overview of the debate surrounding medical humanities and their inclusion in outcomes-based education, the authors outline the medical humanities block, "The History, Theory, and Ethics of Medicine," which is part of the German medical curriculum. A model developed at Ulm University exemplifies the integrated inclusion of the heterogeneous aspects of medical culture into medical education. This model emphasizes a reflexive approach (i.e., understanding how the humanities are manifested in medicine) as an alternative to the currently dominant narrative approach (i.e., liberal arts, moral development, and/or mental retreat), which has gradually been limited to a quasi-"secular religion" for doctors. This model uses established concepts from science and cultural studies as the "instruments" for seminars and courses; paradigms, discourses, social systems, and cosmologies constitute the tools for teaching and learning about the historical, theoretical, and ethical dimensions of medicine. The authors argue that this approach both precludes the need to justify the medical humanities and overcomes the dichotomy that has heretofore existed between the two cultures of science and the humanities in medicine.
Trabalhando pela Igualdade de Gênero na Academia Neoliberal: Entre a Teoria e a Prática

RESUMO Nesta carta executiva, Barbara Poggio relata sua experiência como vice-reitora de igualdade e diversidade da Universidade de Trento (Itália), enfatizando a questão das assimetrias de gênero e os desafios atuais no meio acadêmico. O texto resulta de uma palestra na Faculdade de Negócios da University of Lakehead (Canadá) em junho de 2021. O objetivo da carta é chamar atenção para a implicação de que o ambiente acadêmico predominantemente masculino tem implicações importantes para as condições de trabalho e a qualidade de vida. Além disso, destaca o impacto da atual transformação acadêmica e a afirmação da agenda neoliberal, enfatizando a performatividade, a excelência e a competição, e as implicações em termos de crescente precariedade.
Harmonized ROCKfall natural risk and protection forest mapping in the ALPine Space

In natural hazard management and disaster risk reduction worldwide, but especially in the Alpine Space , forests are increasingly considered equal to technical or civil engineering measures. Forests can, e.g. lead to increase slope stability and reduce the risk to an acceptable level in many locations. Where forests are present, the implementations of technical measures for risk reduction are often redundant or cheaper. Beautiful examples are the numerous forests throughout the Alps that prevent the release of snow avalanches instead of expensive snow racks and the large scale afforestation in the late 19th century that nowadays prevent upslope erosion and sedimentation problems in the lower parts of the Alpine catchments. The preservation and enhancement of the protective role of forests against natural risks are key to an efficient strategy for strengthening the liveability of the AS. The 6 Pan EU Ministerial Conferences on the Protection of Forest held since 1990, have all stressed the need for a common approach to value Forest Ecosystem Services (FES) as a basis for developing a Sustainable Forest Management. Priorisation of FES has to be done on the basis of societal needs. _x000D_
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Although it is widely recognised that reduction of natural hazard risks is one of these, harmonised methods mapping this FES are currently not available. Within this context, ROCKtheALPS will capitalise the knowledge gained in previous EU projects and fulfil its main objectives to provide the 1st AS regional rockfall risk zoning tool, as well as the 1st AS wide harmonised map of rockfall risk and protection forests, these innovative maps will contribute to enhance action 8 of EUSALP (improving risk management), and the action 5 of Europe 2020 biodiversity strategy (FES mapping/valuing).These outputs will support local/regional/national/EU governance authorities in risk prevention/forest management. An interdisciplinary/transnational partnership has been set up with a 1.86 M€ ERDF budget.
MEDITERRANEAN LIFE STYLE

The main objective of the project is supporting and promoting tourism through the creation of the common brand “Mediterranean Lifestyle” linked to local excellencies and best practices of most representative sectors: gastronomy, typical products, natural and cultural resources, handicraft. The main project deliverables include: • A field survey to define MedLS rules and a Manual • Identification of members that can be immediately part of the circuit awarding the MedLS plate. • A Road Show aiming at promoting the Circuit towards local entrepreneurs • A MedLS Associates Guide (EN,IT,GR) • Creation of Informative Front Offices within public structures • International Fairs about Mediterranean LifeStyle • Info activities in all involved schools and delivery of educative material including a videogame and a kitchen course • A permanent press office and a web site
Protocolos terapêuticos utilizados para pacientes hipertensos em uma clínica odontológica de uma universidade do sul de Minas Gerais

A Hipertensão Arterial Sistêmica (HAS) é uma doença crônica multifatorial, onde o paciente apresentará casos de elevação persistente dos níveis pressóricos, igual ou acima de 140/90 mmHg. Esta doença é um dos principais fatores de risco cardiovascular e de alta prevalência em quase todos os países. Tal patologia pode ser exacerbada no consultório odontológico visto que, o cenário pode desencadear situações estressantes como a ansiedade. Além disso, durante ou após os procedimentos odontológicos podem ser administrados drogas que possam interferir no sistema vascular como os vasoconstritores ou fármacos que interagem na função dos anti-hipertensivos. Trata – se de um estudo epidemiológico, descritivo, transversal, com abordagem quantitativa, onde a população-alvo foi constituída de pacientes hipertensos de uma Clínica Odontológica de uma Universidade no Sul de Minas Gerais, a fim de avaliar os protocolos terapêuticos utilizados durante o atendimento odontológico. Os dados coletados foram organizados e apresentados através de tabelas, computando-se as frequências absoluta e percentual. Dos prontuários foram coletados informações dos valores pressóricos, procedimentos realizados, gênero, faixa etária, medicamentos anti-hipertensivos e complicações após o tratamento. Foi observada uma incidência de 20,8% de pacientes hipertensos frente ao tratamento odontológico, onde 63,19% da amostra analisada de pacientes hipertensos são do gênero feminino e 36,81% são de pacientes do gênero masculino. A hipertensão arterial representa elevado risco para sociedade. Portanto, é necessário atenção e responsabilidade dos profissionais e acadêmicos de Odontologia com esse grupo de pacientes.
Intrapopulation communication and collective cell decisions of hematopoietic stem cells

Hematopoietic stem cells (HSCs) contribute to blood cell production throughout life and are found at rare, yet tightly regulated frequencies in adult bone marrow (BM). During embryonic and postnatal development, HSCs expand through continuous self-renewing proliferation. Upon entry into adulthood the vast majority of HSCs synchronously convert to a quiescent state. From then on, at any given moment very few HSCs are found in active stages of cell cycle, which suffices to compensate basal HSC loss due to differentiation or cell death. Since proliferation rates of individual HSCs are heterogeneous, entry and exit from cell cycle need to be coordinated at the level of the HSC pool. To date, the mechanisms that orchestrate this collective proliferative behavior and effectively control the maintenance of homeostatic HSC numbers remain unknown. In preliminary work for this project we have customized a pipeline that combines 3D microscopy, deep learning-based image analysis and spatial statistics. Using these tools, we observed that despite showing broad spatial heterogeneity, HSCs tend to cluster and accumulate in relatively large regions of the BM. We now postulate that molecular crosstalk between proximal HSCs enables them to perceive their local densities and triggers collective regulation of HSC function to preserve homeostasis. Through a multidisciplinary approach involving high-level microscopy, spatial analyses, comprehensive metabolomic profiling and single-cell transcriptomics we aim to 1) characterize the basic anatomical and functional features of spatial dependencies between HSCs 2) study the potential role of quorum-sensing mechanisms in HSC crosstalk and 3) investigate if competition for molecular resources in local neighborhoods contributes to maintenance of HSC homeostasis. Our research has the potential to unravel novel complex forms of cellular interplay and substantially advance our understanding of hematopoietic tissue organization.
SOLUBLE RECOMBINANT ENDOSTATIN AND METHOD OF MAKING SAME FROM STREPTOMYCES SP

A method of making soluble recombinant endostatin in Streptomyces is disclosed. Preparations containing the soluble recombinant endostatin are provided for the inhibition of angiogenesis or the treatment of cancer. Assays using the soluble recombinant endostatin are also provided.
Chemical analysis of CH stars – I. Atmospheric parameters and elemental abundances

Results from high-resolution spectral analyses of a selected sample of CH stars are presented. Detailed chemical composition studies of these objects, which could reveal abundance patterns that in turn provide information regarding nucleosynthesis and evolutionary status, are scarce in the literature. We conducted detailed chemical composition studies for these objects based on high resolution (R ~ 42000) spectra. The spectra were taken from the ELODIE archive and cover the wavelength range from 3900 to 6800 A, in the wavelength range. We estimated the stellar atmospheric parameters, the effective temperature Teff, the surface gravity log g, and metallicity [Fe/H] from Local thermodynamic equilibrium analyses using model atmospheres. Estimated temperatures of these objects cover a wide range from 4550 K to 6030 K, the surface gravity from 1.8 to 3.8 and metallicity from -0.18 to -1.4. We report updates on elemental abundances for several heavy elements and present estimates of abundance ratios of Sr, Y, Zr, Ba, La, Ce, Pr, Nd, Sm, Eu and Dy with respect to Fe. For the object HD 188650 we present the first abundance analyses results based on a high resolution spectrum. Enhancements of heavy elements relative to Fe, that are characteristic of CH stars are evident from our analyses for most of the objects. A parametric model based study is performed to understand the relative contributions from the s- and r-processes to the abundances of the heavy elements.
Method and apparatus for controlling antenna beams within a cellular communication system

A beam control subsystem (200, FIG. 2) provides acquisition, synchronization, and traffic beams (142, FIG. 1) to communication devices (130) within a footprint (144) of a system node (110), where each beam comprises a set of beamlets (140). The subsystem (200, FIG. 2) first acquires (302, FIG. 3) and synchronizes (304, FIG. 3 and FIG. 6) with each communication device. Acquisition involves selecting (402, 416, FIG. 4) and combining (404) sets of beamlets (506, 510, FIG. 5), and determining whether any devices within the sets are attempting to acquire the system. If so, synchronization is performed by varying (604, FIG. 6) beamlet weighting coefficients to find, based on modem feedback, a combination of coefficients that yields a maximum signal-to-interference + noise ratio for multiple users within a beam. The communication device is then handed off (612, 614) to a traffic beam. The subsystem (200) continues, based on modem feedback, to adapt (802, 804, FIG. 8) beamlet weighting coefficients in order to track the traffic beam in a manner that provides the maximum SINR. <IMAGE>
A method for delineating riparian forests using region-based image classification and depth-to-water analysis

Riparian formations are often narrow strips of vegetation near the banks of streams governed by good water availability. With the advent of high-resolution satellite imagery, the study of riparian forests using space-borne remote sensing has gained more attention. However, the sole use of remotely sensed data is seldom sufficient to delineate riparian forests and their special hydrological and geomorphological context should also be considered. In this study, we propose a twofold method to delineate riparian forests in a Brazilian savannah context. Four sites on the banks of the Pandeiros River were used to test our approach, each in a different hydrological context. In our approach, the hydrographic network and a digital surface model are processed using the depth-to-water analysis to create a mask of the riparian zone, then the riparian forests are extracted using region-based image classification. Both steps are fully explained. Three region-based image classification programs e-Cognition, Sistema de Processamento de Informacoes Georeferenciadas SPRING, and MAGIC map-guided ice classification are briefly described and tested. A special validation scheme was created using the independent interpretation of five photo-interpreters to test the accuracy of the results. All three programs achieved a success rate of over 90%. The approach is also tested on a much larger area of the Pandeiros River to assess its applicability in a more operational context. The discussion focuses on methodological issues and the advantages and drawbacks of the approach.
On-line Verification Principle Based on Inverse Process of Protection Setting

In view of the current inadequate method of protection range verification,and from a comparative analysis of the differences and relations between protection setting and verification,it is concluded that verification is the inverse process of protection setting.On this basis and taking into consideration the idea of protection setting calculation,an on-line verification method based on the inverse process of protection setting is presented and the universal formulae and principles of on-line verification on distance protection are given.Furthermore,some specific problems are given corresponding treatment.The style of the method presented is consistent with the protection setting calculation,making it easy for users to quickly divert from setting calculation to verification calculation.The correctness and feasibility of this method is verified by practical examples.
How social media practices shape family business performance: The wine industry case study

The purpose of this paper is to investigate how family businesses utilise social media tools, to determine what the purposes, benefits and challenges are, and to discover competencies that are important in social networking and cooperation. A multiple case study method was employed based on semi-structured interviews with six wineries located in the Balaton region, Hungary. The interviewees and the wineries they represented were selected among the 55 wineries applying the non-probability sampling purposive technique and the interviews were analysed using a case study method and qualitative content analysis. The results show that Facebook is the most popular social media tool that wineries use to increase brand awareness and reach new potential customers. This study also presents a “Social media roadmap” framework for good practice and proposes practical steps family businesses may take to help them succeed in their marketing activities.
Early-Life stressors and lifecycle health

Early life is an important window of opportunity to improve health across the full lifecycle. European pregnancy and child cohort studies together offer an unique opportunity to identify a wide range of early life stressors linked with individual biological, developmental and health trajectory variations, and to the onset and evolution of non-communicable diseases. LIFECYCLE will establish the EuroCHILD Cohort Network, which brings together existing, successful pregnancy and child cohorts and biobanks, by developing a governance structure taking account of national and European ethical, legal and societal implications, a shared data-management platform and data-harmonization strategies. LIFECYCLE will enrich this EuroCHILD Cohort Network by generating new integrated data on early life stressors related to socio-economic, migration, urban environment and life-style determinants, and will capitalize on these data by performing hypothesis-driven research on early life stressors influencing cardio-metabolic, respiratory and mental health trajectories during the full lifecycle, and the underlying epigenetic mechanisms. LIFECYCLE will translate these results into recommendations for targeted strategies and personalized prediction models to improve health trajectories for current and future Europeans generations by optimizing their earliest phase of life. To strengthen this long-term collaboration, LIFECYCLE will organize yearly international meetings open to pregnancy and child cohort researchers, introduce a Fellowship Training Programme for exchange of junior researchers between European pregnancy or child cohorts, and develop e-learning modules for researchers performing life-course health studies. Ultimately, LIFECYCLE will lead to a unique sustainable EuroCHILD Cohort Network, and provide recommendations for targeted prevention strategies by identification of novel markers of early life stressors related to health trajectories throughout the lifecycle.
Directed evolution of photoredox powered artificial metalloenzymes for stereodivergent catalysis

Artificial metalloenzymes have recently emerged as powerful tools to address the ever-growing requirements of chemistry to become more efficient and sustainable. This methodology involves anchoring a reactive transition metal catalyst within a protein to exploit the secondary coordination sphere created around the new active site, which can induce selectivity in reactions and improve turnover numbers.
Concomitantly, photoredox and metallophotoredox catalysis, where a small quantity of a light sensitive compound allows non-traditional reactivity though open shell reactive intermediates, has also developed dramatically in recent years. The impressive reaction repertoire is especially synthetically attractive due to the mild conditions required and the ability to activate abundant and generally more inert functional groups. However, the current drawback to this methodology is the high levels of control needed to give the reactions their full synthetic potential. 
This is where the two fields display complementarity with an unexplored interface: Photoredox Artificial Metalloenzymes.
By anchoring a nickel catalyst inside an enzyme pocket with a nearby photocatalyst, it should be possible to control catalytic reactivity by mutagenesis of residues in the secondary coordination sphere. In the proposed case of an sp3-sp3 cross-coupling reaction between a racemic amino acid derivative and bromoalkane, this could potentially allow control over both new stereocentres independently to achieve stereodivergent catalysis. 
It is subsequently proposed that this methodology could be adapted to include intramolecular cross-coupling reactions, which would beneficially allow access to the valuable monocyclic β-lactam scaffold from suitably functionalised linear substrates. If possible, this may allow efficient access to diastereoisomers potentially difficult to access by other means, which may hold unexplored pharmaceutical potential.