SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Abstract 444: BRM/SMARCA2 is a critical synthetic lethal target in BRG1-deficient cancers

The mammalian SWI/SNF complexes (mSWI/SNF) regulate chromatin structure through ATP-dependent nucleosome remodeling and thereby control key cellular processes. Recent cancer genome studies have revealed a significant frequency of mutations in several components of the mSWI/SNF complexes including the catalytic subunit BRG1. Emerging evidence is supportive of tumor suppressor roles for mSWI/SNF subunits, yet the inactivating nature of these mutations presents a challenge for devising targeted therapeutic strategies against cancers harboring such mutations. In this study, we interrogated epigenetic cancer dependencies by screening a deep-coverage design (DeCoDe) shRNA library targeting the epigenome across a broad range of 50+ cancer cell lines. Strikingly, this unbiased screen revealed that silencing of the SWI/SNF ATPase subunit BRM/SMARCA2, selectively inhibits the proliferation of BRG1-deficient cancer cells. BRM knockdown selectively induced cell cycle arrest in BRG1-mutant cancer cells and significantly impaired the growth of BRG1-mutant lung tumor xenografts. BRM is the paralog of BRG1, suggesting a model in which mSWI/SNF mutations lead to a hypomorphic complex that promotes tumorigenesis but cannot tolerate complete inactivation. Thus, targeting mSWI/SNF subunits that exhibit redundant activities to the residual mutated complexes may present a general strategy for SWI/SNF mutated cancers. Citation Format: Mariela Jaskelioff, Gregory Hoffman, Rami Rahal, Kay Xiang, Kristy Haas, Veronica Saenz-Vash, Huili Zhai, Nicholas Keen, Frank Stegmeier, Zainab Jagani. BRM/SMARCA2 is a critical synthetic lethal target in BRG1-deficient cancers. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 444. doi:10.1158/1538-7445.AM2014-444
INJECTION TOOL AND A METHOD FOR INJECTION

This invention relates to an injection tool (1) which comprises a longer smaller diameter pipe (3) assembled movable inside a shorter larger diameter pipe (4), a connection piece (2) assembled at the first end of the smaller diameter pipe (3), a projecting part (8) connected to the smaller diameter pipe (3) near the connecting piece (2), the projecting part (8) having an opening or groove for a bolt (10), a projecting part (9) connected near to the first end of the larger diameter pipe (4) the projecting part (9) having threaded opening for the bolt (10), the bolt (10) connecting the projecting parts (8, 9) and the bolt (10) having a fixed stopper plate (11), a nose piece (7) assembled to the second end of the smaller diameter pipe (3), a press plate (5) assembled to the second end of the larger diameter pipe (4) and a sealing rubber (6) around the smaller diameter pipe (3) situated between the nose piece (7) and the press plate (5). This invention also relates to a method for injection which comprises the steps of entering the injection tool (1) to the borehole, tightening the injection tool (1) to the borehole, connecting the injection machine to the injection tool (1), starting the injection, and an forming automatically functioning valve to the nose piece (7) at the second end of the injection tool.
PROCESS FOR THE PREPARATION OF DROSPIRENONE AS A FINE POWDER THROUGH A DOUBLE CHANGE OF CRYSTALLINE FORM

The present invention refers to a process for the industrial-scale preparation of 17β-hydroxy- 6β,7β;15β,16β-dimethylene-3-oxo-17α-pregn-4-ene-21-carboxylic acid y-lactone, known by the common name of Drospirenone, in the form of a fine powder without the use of mechanical grinding or micronization techniques, but rather exploiting a double change of crystalline form, from Crystalline Form I to Crystalline Form II and from Crystalline Form II to Crystalline Form I. The invention also refers to the new Crystalline Form II of Drospirenone obtained in the process.
INVERSIONES 4.0 EN LA CADENA DE ENVASADO DE ALIMENTOS

EL PRESENTE PROYECTO SE REFIERE A LA CREACIÓN DE UNA NUEVA PLANTA E INCLUYE UN PROGRAMA DE INVERSIÓN CAPAZ DE AUMENTAR LOS NIVELES DE EFICIENCIA, EFICACIA Y CALIDAD DE LA PRODUCCIÓN, A TRAVÉS DE LA MODIFICACIÓN DE LA LÍNEA DE EXTRUSIÓN EN ÓPTICA 4.0 CON LA MODIFICACIÓN DEL CABEZAL PARA EL CONTROL AUTOMÁTICO Y LA INTEGRACIÓN DE SENSORES DE MEDICIÓN Y CONTROL Y LA ADQUISICIÓN DE UN CORTADOR DE REBOBINADO BIEJE CON PANEL DE CONTROL DE PARÁMETROS Y ESTADO OPERATIVO. SÉ LA L
DEVICE FOR DRIVING A CLOSURE OR SHADING MEMBER IN A BUILDING BY MEANS OF A SOLAR ENERGY SOURCE

Disclosed is a device for driving a closure member (9) in a building by means of a solar energy source (1), comprising at least one low-voltage AC electric motor (3) mechanically coupled with the closure member, a DC electrical energy storage element (2) and a solar energy source delivering a DC electrical voltage. The electrical energy storage element has a nominal voltage less than said effective electrical voltage and greater than the DC electrical voltage delivered by the solar energy source. A DC-DC charger (4) converts the electrical energy from the output of the solar energy source into an electrical energy at the electrical charging voltage of the electrical energy storage element. A DC-AC converter (5) transforms the output electrical energy with DC electrical voltage of the electrical energy storage element into an electrical energy with AC voltage capable of supplying the electric motor.
Permanent bilateral mydriasis after treatment with nivolumab/ipilimumab for cutaneous melanoma

To compare the refractive outcomes of sutureless scleral-fixated Carlevale® intraocular lenses versus Artisan® iris-claw-fixated lenses in terms of surgically induced astigmatism.We included patients from the Quinze-Vingts National Ophthalmology Hospital, Paris, from August 2020 to December 2020.This was a single-center retrospective study.Each patient included had undergone surgery with a sutureless scleral-fixated Carlevale® foldable intraocular lens or an Artisan® iris-claw lens in the context of secondary implantation. Exclusion criteria included a history of retinal detachment or any other retinal disease. We analyzed postoperative refractive data three months after surgery for the Carlevale group and three months after removal of all sutures for the Artisan group.A total of 25 eyes of 25 patients were included in the Carlevale group and 37 eyes of 36 patients in the Artisan group. At three months, the best-corrected visual acuity was not statistically different, at 0.33(± 0.35) and 0.32(± 0.33) LogMAR, respectively (P = 0.99), and surgically induced astigmatism was significantly lower in the Carlevale group, at 0.538 (± 0.560) and 2.30 (± 3.97) Diopters, respectively (P < 0.001).In this first comparative study, Carlevale® intraocular lenses appear to offer better refractive accuracy and less induced astigmatism than Artisan® iris-claw lenses, without increasing mean surgical time.Comparer les résultats réfractifs des implants a fixation sclérale sans suture de type Carlevale® par rapport aux implants à fixation irienne de type Artisan® en termes d’astigmatisme chirurgicalement induit.Nous avons réalisé une étude rétrospective et monocentrique au centre hospitalier national d’ophtalmologie des Quinze-Vingts de patients inclus entre août 2020 et décembre 2020. Chaque patient inclus a bénéficié d’une chirurgie avec pose d’un implant intra-oculaire à fixation sclérale sans suture de type « Carlevale® » ou clippé à l’iris de type « Artisan® » dans un contexte d’implantation secondaire. Nous avons exclu de l’étude tous les patients avec un antécédent de rétinopathie ou de décollement de rétine. Nous avons analysé les résultats réfractifs post-opératoires 3 mois après la chirurgie pour le groupe Carlevale et 3 mois après le retrait des points de suture cornéens pour le groupe « Artisan® ».Au total, 26 yeux de 26 patients ont été inclus dans le groupe « Carlevale » et 37 yeux de 36 patients dans le groupe « Artisan ». À 3 mois, la meilleure acuité visuelle corrigée n’était pas statistiquement différente dans les deux groupes avec respectivement 0.33(± 0,35) et 0,32(± 0,33)LogMAR, p = .99. L’astigmatisme chirurgicalement induit était significativement inférieur dans le groupe « Carlevale® » versus « Artisan® » avec respectivement 0,538 (± 0,560) et −2,30 (± 3,97)Dioptries, p < 0.001.Dans cette première étude comparative, les implants Carlevale® semblent entraîner un astigmatisme chirurgicalement induit inférieur et une meilleure précision réfractive que les implants clippés à l’iris, et ce, sans allongement du temps opératoire.
Promotion of Multimodal Transport in Chemical Logistics

The chemical industry is an important economic sector in Central Europe with 117 billion Euro turnover and 340.000 employees. The chemical companies are important logistic stakeholders responsible for 8% of freight transport. The industry has the objective to strengthen multimodal transport and modal shift from road to rail with strong focus on improvement of safety and security in combination with increased logistics efficiency. The optimisation of the supply chain is a crucial for long-term competitiveness.

The main objective of ChemMultimodal is the promotion of multimodal transport of chemical goods by coordination and facilitation of cooperation between chemical companies, specialised logistics service providers (LSP), terminal operators and public authorities in chemical regions in CE.

Based on a detailed analysis of the needs for improving multimodal transport of chemical goods, the project will develop a toolbox to support chemical companies and LSP in their strategic and operational planning for increasing the share of multimodal transport. This toolbox will be tested in 7 pilots with 35 chemical companies in the partner countries to facilitate real modal shift. In these pilots it is the objective to increase multimodal transport by 10% and reduce CO2 footprint by 5% until the end of project duration.  1 Common Strategy and 7 Regional/National Action Plans will be developed to continue and intensify activities after the project end.

The new quality of cooperation between private and public entities with support of a dedicated tool is innovative and will improve coordination of multimodal stakeholders across boarders in CE and contribute directly to modal shift. An intensive collaboration with European Chemical Regions Network and European Chemical Industry Council will ensure mainstreaming at EU level.
Increasing measurement accuracy of age-related BOLD signal change: Minimizing vascular contributions by resting-state-fluctuation-of-amplitude scaling

In this report we demonstrate a hemodynamic scaling method with resting-state fluctuation of amplitude (RSFA) in healthy adult younger and older subject groups. We show that RSFA correlated with breath hold (BH) responses throughout the brain in groups of younger and older subjects which RSFA and BH performed comparably in accounting for age-related hemodynamic coupling changes, and yielded more veridical estimates of age-related differences in task-related neural activity. BOLD data from younger and older adults performing motor and cognitive tasks were scaled using RSFA and BH related signal changes. Scaling with RSFA and BH reduced the skew of the BOLD response amplitude distribution in each subject and reduced mean BOLD amplitude and variability in both age groups. Statistically significant differences in intrasubject amplitude variation across regions of activated cortex, and intersubject amplitude variation in regions of activated cortex were observed between younger and older subject groups. Intra- and intersubject variability differences were mitigated after scaling. RSFA, though similar to BH in minimizing skew in the unscaled BOLD amplitude distribution, attenuated the neural activity-related BOLD amplitude significantly less than BH. The amplitude and spatial extent of group activation were lower in the older than in the younger group before and after scaling. After accounting for vascular variability differences through scaling, age-related decreases in activation volume were observed during the motor and cognitive tasks. The results suggest that RSFA-scaled data yield age-related neural activity differences during task performance with negligible effects from non-neural (i.e., vascular) sources.
Comparison of microstructures and thermal insulation capability of plasma sprayed nanostructured and traditional YPSZ coatings

AbstractMicrostructural features and thermal insulation capability of plasma sprayed nanostructured and traditional yttria partly stabilised zirconia (YPSZ: ZrO2–8Y2O3) coatings were investigated. Both nanostructured YPSZ coating and traditional YPSZ coating were mainly composed of non-transformable t-ZrO2 phases. The detailed microstructures of the nanostructured YPSZ coating were observed using FESEM, which presented three types of microstructures: columnar grains, equiaxed grains and nanosized zirconia particles embedded in the so called matrix formed by melted powders. However, the traditional YPSZ coating only contained columnar and equiaxed grains. The average porosities of nanostructured and traditional YPSZ coatings are 12·5 and 9·7% respectively. Compared with the traditional YPSZ coating, the nanostructured coating contained finer microcracks. The nanostructured YPSZ coating has higher thermal insulation capability than the traditional YPSZ coating. For YPSZ coating of 200 μm in thickness, the t...
Gelenkerhaltende Hüftchirurgie im Erwachsenenalter

Deformity and malposition of the acetabulum can occur during the development of the hip. Developmental hip dysplasia and acetabular retroversion are possible causes of osteoarthritis in the young adult. Surgical management with reorientation of the acetabulum allows causal therapy of the deformity and preservation of the native hip joint. Established techniques are the Bernese periacetabular osteotomy (PAO) and the Tönnis and Kalchschmidt triple osteotomy of the pelvis. Both techniques permit three-dimensional correction of the position of the acetabulum. Advantages and disadvantages of each technique must be considered and are summarized in the present paper. If performed early (osteoarthritis grade Tönnis 0 and 1) with correct indication and proper technique, good results can be expected.
METHOD OF PRODUCING HOLLOW FIBRE POLYMER MEMBRANES

The invention concerns a method of producing hollow fibre polymer membranes in which a polymer is guided through an extruder in order to form the hollow fibre membranes. Before entering a melt-forming extrusion tool of the extruder, the polymer is charged under pressure with gas. As a result of a predetermined pressure drop occurring as the polymer leaves the extruder and of the accompanying expansion of the gas in the polymer, a porous hollow fibre membrane is formed.
Relations Between Total Factor Energy Efficiency and Environmental Pollution

Energy and environmental issues have become the focus of the world.By literature review,we found that most of previous studies just analyzed one of the environmental issues separately,but a few studies were on the relations between energy and environment(especially energy efficiency and environmental pollution).There is a close link between the energy efficiency and environmental pollution,so a in-depth and comprehensive study of the relations is necessary.Firstly,we use the methods of DEA and the cost of pollution clearance to calculate Chinese total factor energy efficiency and economic loss caused by environment pollution in 1989-2007.On the basis of the evaluation of relations between the two,by using the cointegration test and Granger causality test,we draw the conclusions of this article: A long-term equilibrium relationship exists between Chinese total factor energy efficiency and economic loss caused by environmental pollution,and the former is the latter's Granger cause.And we find that the short-term energy efficiency fluctuation has an obvious impact to reducing economic loss caused by environmental pollution and the impact is bigger than long-term energy efficiency fluctuation caused by environmental pollution economic loss.This means that the improvement of total factor energy efficiency plays an important role in reducing environmental pollution,which is also important to the goals of energy-saving and emission reduction.
Addressing the Financial Consequences of Cancer: Qualitative Evaluation of a Welfare Rights Advice Service

The onset, treatment and trajectory of cancer is associated with financial stress among patients across a range of health and welfare systems and has been identified as a significant unmet need. Welfare rights advice can be delivered effectively in healthcare settings, has the potential to alleviate financial stress, but has not yet been evaluated. We present an evaluation of a welfare rights advice intervention designed to address the financial consequences of cancer.Descriptive study of welfare outcomes among 533 male and 641 female cancer patients and carers aged 4-95 (mean 62) years, who accessed the welfare rights advice service in North East England between April 2009 and March 2010; and qualitative interview study of a maximum variation sample of 35 patients and 9 carers.Over two thirds of cancer patients and carers came from areas of high socio-economic deprivation. Welfare benefit claims were successful for 96% of claims made and resulted in a median increase in weekly income of £70.30 ($109.74, €84.44). Thirty-four different types of benefits or grants were awarded. Additional resources were perceived to lessen the impact of lost earnings, help offset costs associated with cancer, reduce stress and anxiety and increase ability to maintain independence and capacity to engage in daily activities, all of which were perceived to impact positively on well-being and quality of life. Key barriers to accessing benefit entitlements were knowledge, system complexity, eligibility concerns and assumptions that health professionals would alert patients to entitlements.The intervention proved feasible, effectively increased income for cancer patients and was highly valued. Addressing the financial sequelae of cancer can have positive social and psychological consequences that could significantly enhance effective clinical management and suitable services should be routinely available. Further research is needed to evaluate health outcomes definitely and assess cost-effectiveness.
Services enhancing the innovation management capacity of smes in the enterprise europe network

Lack of innovation management is one of the most important barriers to create economic impact (competitiveness, growth and jobs) from innovation activities in SMEs. The objective of this project proposal is to address these problems by providing services enhancing the innovation management capacity of SMEs.

Four partners in the Swedish Enterprise Europe Network (SweNet) took part in the 2014 pilot action IS/KAM where 25 Swedish SMEs were coached.  The target for this project is to deliver 105 7-day service packages to two SME target groups:

 1) SME beneficiaries of the SME Instrument in Horizon 2020 – to be supported by Key Account Managers (KAM), and 
 2) SMEs with significant innovation activities and a high potential for internationalisation – to be supported by innovation specialists (IS).

The specific objectives related to the first target group of 42 SMEs are to identify weaknesses in their innovation capacities, to identify suitable business coaches for them, and to accompany them through Phase 2 of the SME instrument project.

The specific objectives related for the second target group of 63 SMEs are to carry out diagnostic audits of selected SMEs, to set up action plans to address bottlenecks, and to implement the action plans. 

The partner IVF, Acreo, Centek and SP will cover all of Sweden (all three Nuts 1 regions). The coordinator, The Swedish Agency for Economic and Regional Growth will not be involved in any service activities. The tools to be used to assess the innovation management capacity will be IMP3rove and Innovation Health Check.
Broadband Multiple Cone-Beam 3-D IIR Digital Filters Applied to Planar Dense Aperture Arrays

A digital beamformer that can synthesize array factors (AFs) with multiple, ultrawideband (UWB), frequency-independent beams at lower computational complexity is proposed. The beamformer is based on a novel 3-D infinite impulse response (IIR) transfer function $H_{\rm MC}\left({\bf z}\right)$ having multiple cone-shaped passbands in the 3-D spatio–temporal (ST) frequency-domain $\mmb{\omega}\in\BBR^{3}$ . The magnitude frequency response and the AF of $H_{\rm MC}\left({\bf z}\right)$ are simulated for dual- and single-passband cases. An element pattern of a broadband Vivaldi antenna is simulated at 1.4 GHz and is used to obtain the total array pattern. Computational complexity of $H_{\rm MC}\left({\bf z}\right)$ for single-passband (1Cone) case and that of the conventional phased array (PA) beamformer are derived. The magnitude frequency response of the proposed beamformer for 1Cone case and that of the PA beamformer are compared using the mean square error (MSE). For the given selectivity specified by the half cone angle $\epsilon={\hbox {5}}^{\circ}$ , proposed beamformer provides around 60% lower MSE for the same complexity and around 90% lower complexity for the same MSE compared with the PA beamformer.
PARC MARIN INTERNATIONAL DES BOUCHES DE BONIFACIO

The bilateral project between the Office of the Environment of Corsica and the Maddalena Archipelago National Park comes to the adoption of the Franco-Italian Protocol of 1993. The goal is to create an International Marine Park in the Strait of Bonifacio (PMIBB), which takes the form of a European Grouping of Territorial Cooperation (EGTC-PMIBB) carried out to provide a legal framework for joint actions between the two partners to encourage a continuity of activities conducted in space cooperation, in a logic of complementarity.
 The project partners plan to develop and precisely implement the objectives of method and innovative management methods likely to produce a dynamic effect on the defined geographical area (the joint management plan), but also to testing of an energy plan pilots of two independent sites (island of Lavezzi islands Spread the Italian coast and the French coast), with the prospect of contributing to sustainable development of this common territory of Sardinia and Corsica.
 One of the objectives of the project is also to ensure compliance with the principles of equality within the territory defined, accessible to a wide range of users (local and tourist populations, children and the elderly ...).