SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Prevention of complications to improve outcome in elderly patients with acute stroke

Every year, 1.3 million Europeans have a stroke and one million ultimately die of stroke. One third of stroke patients remain dependent on the help of others. The annual costs for stroke care in Europe are estimated at € 64.1 billion. Stroke incidence increases almost exponentially with age, and the personal, societal, and economic burden of stroke is therefore largely driven by its frequent occurrence in the elderly. The elderly have been strongly underrepresented in previous stroke trials and treatment guidelines have no recommendations specific to this important group. Elderly patients are at the highest risk of complications after stroke, such as infections, fever, and dysphagia. These complications are strongly and independently associated with a higher risk of death or dependency.
We will perform a pragmatic, randomised, open clinical trial with blinded outcome assessment in at least 2500 patients with acute stroke aged 66 years or older, to assess whether pharmacological prevention of infections and fever, and early management of dysphagia, will reduce the risk of death, poor functional outcome, and poor quality of life, and lead to reductions in the costs of stroke care throughout Europe. Patients will be randomised using a factorial design to preventive treatment for 4 days with ceftriaxone, paracetamol, and/or metoclopramide, or to ‘standard care’ alone. The primary outcome is functional outcome at 3 months, assessed with the modified Rankin Scale (mRS), and analysed with ordinal logistic regression. The study will have 80% power to detect a statistically significant shift towards a favourable outcome, assuming a 5% absolute increase in the proportion of patients with a good outcome (mRS 0 to 2) in the intervention group, compared with controls. This simple, safe, and generally available treatment strategy has the potential to lead to an annual reduction of over 25 000 elderly Europeans being dead or dependent as a result of stroke, at very low costs.
QUALITÀ DA TERMINARE

Il processo di introduzione di un esigente certificato EUROVENT, che è alla fine, richiede il rispetto di rigorosi standard di controllo qualità dei prodotti, dei processi di produzione e delle apparecchiature di misura. Per questo motivo, l'azienda ha deciso di introdurre certificati di qualità e gestione ambientale ISO 9001 e ISO 14001 in modo che i processi produttivi siano controllati e possano creare prodotti di qualità. Con l'aggiornamento dell'ERP esistente con nuove funzionalità, il flusso di informazioni e i processi di produzione saranno facilitati e l'ulteriore agevolazione e accelerazione del processo aziendale, la preparazione della documentazione, le vendite, le spedizioni, ecc. si tradurranno in un aumento del reddito, nuovi posti di lavoro, miglioramento di alcuni processi aziendali e garantire la crescita a lungo termine dell'azienda. Il processo sarà incentrato su dipendenti e clienti.
SUBSTITUTED DIPYRIDYLAMINES AND USES THEREOF

The present invention provides for compounds of Formula I and various embodiments thereof, and compositions comprising compounds of Formula I and various embodiments thereof. In compounds of Formula I, the groups R1, R2, R3, R4, R5, R6, m, n and the C-linked Ring have the meaning as described herein. The present invention also provides for methods of using compounds of Formula I and compositions comprising compounds of Formula I as DLK inhibitors and for treating neurodegeneration diseases and disorders.
Lamellae formation processes in tropical soils in southeastern Brazil

Abstract The pedogenic genesis of lamellae is commonly reported as involving clay illuviation. However, some pedogenic lamellae in tropical soils may be formed by a different process involving the degradation of a continuous Bt horizon and an intense loss of clay. In the present work, we investigated soils along a toposequence containing lamellae formed both by illuviation and Bt degradation to better understand the pedogenic processes and the environmental controls associated with the genesis of lamellae in tropical soils. Soils were described and sampled along a hillslope in the Sao Pedro region, Sao Paulo state, and submitted to physical (particle size), chemical (pH and exchangeable cations), and micromorphological analyses. In the Upper Segment of the studied hillslope, dominated by low gradients, the soil is deep, reddish, and contains a sequence of 12 to 20 lamellae/interlamellae. An examination of thin sections revealed abundant illuvial features formed by moderately to strongly oriented clay bridges between sandy particles in the lamellae, supporting an illuvial origin. In the Middle Segment of the hillslope, characterized by higher gradients, the soil is shallower and yellowish, presents some mottles, and contains a sequence of 2 lamellae/interlamellae. Field descriptions showed curved links between these lamellae and the underlying Bt as well as isolated spots similar to lamellae within interlamellae. The lamellae, Bt, curved links, and spots present similar micromorphological characteristics and only a few illuvial features, which suggest a genetic relationship between lamellae and the Bt horizon and minimize the importance of clay illuviation. The origin of these lamellae is related to the degradation of Bt and clay eluviation by subsurface lateral flows, developed mainly in the contact between Bt and the overlying, more permeable horizons. This process seems to be an important way of lamellae formation under tropical climate and should thus be incorporated into the term pedogenic lamellae, which is usually associated in the international literature with lamellae formed by clay illuviation.
Communicating Linear Functions of Correlated Gaussian Sources Over a MAC

This paper considers the problem of transmitting linear functions of two correlated Gaussian sources over a two-user additive Gaussian noise multiple access channel. The goal is to recover this linear function within an average mean squared error distortion criterion. Each transmitter has access to only one of the two Gaussian sources and is limited by an average power constraint. In this paper, a lattice coding scheme and two lower bounds on the achievable distortion are presented. The lattice scheme achieves within a constant of a distortion lower bound if the signal-to-noise ratio is greater than a threshold. Furthermore, for the difference of correlated Gaussian sources, uncoded transmission is shown to be worse in performance to lattice coding methods for correlation coefficients above a threshold.
African therapy for a fractured world(view): The life of founder bishop Johannes Richmond and the invention of tradition and group cohesion in an African Initiated Church

In the book The invention of tradition historian Eric Hobsbawm claims that the process of the invention of tradition serves the formation of group cohesion. The different versions of the life story of the founder bishop of the Corinthian Church of South Africa (AIC), as documented during many years of conducting qualitative field work in this church, are used in this article as a case study in this regard. The article unpacks the way in which the invention of tradition as a process is in this particular AIC currently a work in progress contributing to the formation of a particular type of group cohesion that stretches over racial, religious and denominational boundaries especially by means of the unique liturgical rituals that were influenced by the life story of the founder. The group cohesion that this process fosters is in essence aimed at healing in all its multifaceted dimensions, which includes healing from physical ailments, ‘healing’ from barrenness, healing from spirit possession to healing as (re-)incorporation of an individual into the larger group, the healing of a nation as well as healing from a dualistic spirit-matter worldview.
Eudat2020

EUDAT2020 brings together a unique consortium of e-infrastructure providers, research infrastructure operators, and researchers from a wide range of scientific disciplines under several of the ESFRI themes, working together to address the new data challenge. 

In most research communities, there is a growing awareness that the “rising tide of data” will require new approaches to data management and that data preservation, access and sharing should be supported in a much better way. Data, and a fortiori Big Data, is a cross-cutting issue touching all research infrastructures. 

EUDAT2020’s vision is to enable European researchers and practitioners from any research discipline to preserve, find, access, and process data in a trusted environment, as part of a Collaborative Data Infrastructure (CDI) conceived as a network of collaborating, cooperating centres, combining the richness of numerous community-specific data repositories with the permanence and persistence of some of Europe’s largest scientific data centres. 

EUDAT2020 builds on the foundations laid by the first EUDAT project, strengthening the links between the CDI and expanding its functionalities and remit. Covering both access and deposit, from informal data sharing to long-term archiving, and addressing identification, discoverability and computability of both long-tail and big data, EUDAT2020’s services will address the full lifecycle of research data. 

One of the main ambitions of EUDAT2020 is to bridge the gap between research infrastructures and e-Infrastructures through an active engagement strategy, using the communities that are in the consortium as EUDAT beacons and integrating others through innovative partnerships. 

During its three-year funded life, EUDAT2020 will evolve the CDI into a healthy and vibrant data-infrastructure for Europe, and position EUDAT as a sustainable infrastructure within which the future, changing requirements of a wide range of research communities are addressed.
High power and voltage operation of electric motors in aeronautics

The present proposal tries to answer in the best way the call JTI-CS2-2020-CfP11-THT-12. After the analysis of the call, our understanding of the objectives requested by the call is the following:
The main objective of the project is to investigate solutions for the scientific and technical challenges regarding the use of high voltage high power electric drives at high altitude conditions. Both short and long term timeframes are contemplated, so research into the implications of high voltage and altitude in the reliability and safety of actual systems and its technical solution, but also investigation into new HTS based electric drives for these conditions are proposed.
For this purpose, this main objective splits into the following technical objectives:
•	Investigation on modelling of high voltage electrical systems at high altitude for fundamental understanding of the technical issues related to inverter-fed HV insulation and arcing effects in electrical machines.
•	Research into insulation approaches and assessment of their reliability and safety at high altitude conditions.
•	Electromagnetic, electrical, thermal and mechanical design of actual topologies of electrical machines in order to evaluate the limits of each technology for high power and high voltage operation in aircraft applications.
•	Comparison of available and foreseen HTS materials for their use in electric machines for high volumetric and mass power density.
•	Investigation on thermal management systems for cryo-cooled HTS windings for electric machines in aircraft environment.
•	Preliminary design and comparison of different HTS based electric machine topologies for aircraft applications at high voltage and high altitude in terms of power density, reliability and safety.
•	Full design of a HTS electric motor concept and development of a lab-scale validator, applying the most suitable techniques investigated during the project for HV and high altitude operation, including the thermal management.
The wood pellet market in Austria: A structural market model analysis

Abstract EU bioenergy policies and oil price hikes have resulted in a significant increase of installed pellet boilers for residential heating. Hence, European demand for wood pellets has been growing faster and more steadily than supply leading to rising market prices in recent years. This article presents an econometric analysis of demand and supply of wood pellets in the residential heating sector in Austria, one of the most dynamic markets for residential pellets. Annual and monthly time series data between 2000 and 2014 are used in a two-stage least-squares (2SLS) regression to estimate supply and demand elasticities of wood pellets. In all model specifications, pellets demand is found to be inelastic (from −0.66 to −0.76) and pellets supply unit-elastic (from 1.03 to 1.18). Thus, consumers are highly exposed to price changes resulting from supply shocks. Policies which support investments in pellet boilers will shift the demand of wood pellets and likely leading to higher prices for consumers.
Finanzhilfe für ART CAFE JOLANTA Duchnik zur Finanzierung des Working Capital und zur Sicherstellung des laufenden Betriebs

Das Projekt betrifft die Unterstützung des Betriebskapitals eines Unternehmens im Falle eines Umsatzrückgangs (Umsatzerlöse), der durch die negativen Auswirkungen des COVID-19-Ausbruchs verursacht wird.
4-OXO-4, 7-DIHYDROFURO[2,3-B]PYRIDINE-5-CARBOXAMIDE ANTIVIRAL AGENTS

The invention provides a compound of formula I: (I) Wherein G, R2, R3, and R4 have any of the values defined in the specification, or a pharmaceutically acceptable salt thereof, as well as processes and intermediates useful for preparing such compounds or salts, and methods of treating a herpesvirus infection using such compounds or salts.
Dietary Reconstruction Of Urban Inhabitants Of The 1St Century AD Petra

Petra, an ancient city located in southern Jordan, is a UNESCO World Heritage site known for its architecturally grand buildings and tombs carved into sandstone bedrock. The establishment of Petra as the capital of the Nabataean kingdom heralded the beginning of the sedentarization of the rulers of the Nabataean people. Petra rose to prominence between the 2nd century B.C. and 1st century A.D. where up to 30,000 Nabataean people may have lived. Despite decades of archaeological excavations at Petra, little is known about how these inhabitants of such a large city could have supported themselves in a semi-arid environment. This study reconstructs the diet of the non-elite Nabataeans from the 1st century A.D., whose remains were excavated from the Petra North Ridge Tombs. The residents of Petra, like many ancient cities, likely relied the hinterland for food items and it is expected that the residents supplemented their diet by importing foods to support their large population and to provide variability to the peoples' diet. Here, we use a multidisciplinary approach to reconstruct the diet of the non-elite Nabataeans. This approach includes an analysis of carbon and nitrogen stable isotopes of human and faunal remains, combined with paleobotanical, archaeological, zooarchaeological and papyrological data. Stable isotope analysis revealed that the non-elite Nabataeans had relatively homogenous [delta]Â¹Â³C and [delta]Â¹â�µN bone collagen and apatite values which indicates that non-elite. Petraeans may have ate a similar diet that relied water-intensive Câ‚ƒ plants such as barley and wheat along with meat and secondary products from animals. Evidence of local agriculture production from papyrological, archaeological and paleobotanical sources indicate that Câ‚ƒ plants were grown and zooarchaeological data indicates that herd animals were brought in on the hoof for consumption. While these data cannot directly identify reliance imported foods within Petra, the consumption of plant types not suited for Petra's arid environment may suggest they supplemented some locally grown crops with those imported from elsewhere. Finally, through the use of a multidisciplinary approach the data produced allows a more informed interpretation for future isotope studies.
“Housing Quality” To the Low Income Housing Producers in Ogbere, Ibadan, Nigeria

Abstract The paper discusses how housing produced by the poor in Ogbere area of Ibadan is negotiated from the societal complex due to the inability of government to provide for them and low income housing not being attractive to the profit driven private sector. The contextual case study utilises quantitative and qualitative methods and adopts the lens of Lefebvre's theory of space to examine the people and the process in relation to the houses produced. The findings necessitate ‘social totality’ approach to intervening in improving the housing quality of low income people to upgrade the quality of life in urban areas.
Ubiquitous computing in emergency: Role-based situation response based on self-organizing resource network

Smart environment is defined here as a number of devices that can share information and services independently of their physical location. Smart environments based on ubiquitous computing open new possibilities to various aspects of human activities. The paper proposes an approach to emergency situation response that benefits of the ubiquitous computing. The approach is based on utilizing role profiles to facilitate the coordination of the activities of the emergency response operation members. Emergency response operations usually involve different people and organizations with different subordination. As a result, the centralized control is often impossible. The idea behind the approach is to self-organize resources of the smart environment according to the state of the situation caused by the accident. The resources self-organize a collaborative network that comprises physical devices, software services, organizations, and persons to undertake joint actions for accident response. The accident response system intended for operating in smart environments has a service-oriented architecture. Some of Web-services making up the architecture are intended to model the accident situations; others model resource functionalities or bear supporting functions. Web-services that model resource functionalities are aligned against the emergency situation management ontology. This alignment ensures semantic interoperability of the heterogeneous resources. A case study illustrates main ideas presented in the paper.
Phev towards zero emissions & ultimate ice efficiency

PHOENICE aims at developing a C SUV-class plug-in hybrid (P1/P4) vehicle demonstrator whose fuel consumption and pollutant emissions will be jointly minimized for real world driving conditions. This development will require the optimisation of a highly efficient gasoline engine, relying on a dual dilution combustion approach with excess air and EGR, synergizing an innovative in-cylinder charge motion with high pressure injection, novel ignition technologies, and an electrified turbocharger particularly relevant for hybrid architectures. The potential of alternative fuels produced by P2X processes will also be considered. To achieve the targeted near-zero emissions in transient conditions specific to PHEV in real driving conditions, the demonstrator vehicle will be equipped with a complete and dedicated after-treatment system including an electrically heated catalyst, a SCR and a GPF for abating NOx, particle number down to 10 nm, and non-regulated gaseous emissions.
The vehicle overall efficiency will be increased with an exhaust waste heat recovery system for generating an additional electric power contribution for cabin heating or cooling, or for reducing the switch-on time of the internal combustion engine in cold conditions, thereby limiting the engine-out pollutant emissions such as particles. 
Virtual methods will be employed to reduce the calibration time of all the vehicle sub-systems. The vehicle control will use all the flexibility of the hybrid architecture and sub-systems to lower in real time the driving emissions and fuel consumption.
Technologies developed in PHOENICE will achieve a TRL 7 paying a specific attention to cost, industrialization, and to the use opportunity for various vehicle classes so as to maximize the economic and environmental impacts. This project will support the European automobile industry in the medium term and speed up the transition towards a more environmentally friendly mobility in terms of air quality and GHG emissions.
[Effects of erythropoietin on cardiomyocyte apoptosis and endoplasmic reticulum stress-related proteins in neonatal rats with asphyxia].

OBJECTIVE To study the effects of erythropoietin (EPO) on cardiomyocyte apoptosis and endoplasmic reticulum stress (ERS)-related proteins, glucose-regulated protein 78 (GRP78) and C/EBP homologous protein (CHOP), in neonatal rats with asphyxia. METHODS A total of 120 newborn Sprague-Dawley rats (7 days old) were randomly divided into sham-operated (n=40), asphyxia (n=40) and EPO-treated asphyxia groups (n=40). A neonatal rat model of normobaric asphyxia was established in the asphyxia and EPO-treated asphyxia groups. The rats in the EPO-treated asphyxia group received intraperitoneal injection of recombinant human erythropoietin (500 U/mL) immediately after the model was established, while the other two groups received the same volume of normal saline (0.9%). Heart blood and myocardial tissue samples were collected from 8 rats in each group at 2, 6, 12, 24 or 48 hours after the model was established. Serum creatine kinase (CK) and lactate dehydrogenase (LDH) levels were measured; cardiomyocyte apoptosis was evaluated, and expression of myocardial GRP78 and CHOP was measured. RESULTS Compared with the sham-operated and EPO-treated asphyxia groups, the asphyxia group had significantly increased serum CK and LDH levels, number of apoptotic cells, and expression of myocardial GRP78 and CHOP at each time point (P<0.01), and all the indices were significantly higher in the EPO-treated asphyxia group than in the sham-operated group (P<0.01). At 24 hours after asphyxia, the expression of myocardial CHOP was positively correlated with the myocardial apoptosis index (r=0.944, P<0.01). CONCLUSIONS EPO exerts a protective effect on the myocardium of neonatal rats with hypoxic-ischemic injury by regulating ERS-related proteins GRP78 and CHOP and reducing cardiomyocyte apoptosis.
Graphene oxide-based biosensor for detection of platelet-derived microparticles: A potential tool for thrombus risk identification

We report here design of a graphene oxide-based electrochemical biosensor for detection of platelet-derived microparticles (PMPs), a major risk factor for arterial pro-thrombotic pathologies like acute myocardial infarction and stroke. Electrodes were fabricated with immobilized layers of graphene oxide and a specific antibody targeted against active conformation of integrin αIIbβ3 on PMP surface. Results showed progressive rise in impedance in Nyquist plots with increasing number of PMPs in analyte. The sensor was highly specific for PMPs and did not identify microparticles originating from other cells. Blood obtained from patients diagnosed with acute myocardial infarction exhibited significantly higher values of impedance, consistent with larger number of circulating PMPs in these patients, as compared to samples from healthy individuals, thus validating biosensor as a specific, sensitive, label-free and cost-effective tool for rapid point-of-care detection of PMPs at bedside. Our biosensor is most ideal for mass population screening programs at periphery-level healthcare units with limited resources. It is aimed at early detection of individuals having higher imminent cardiovascular risk, as well as for routine analysis, which in turn would contribute to better management and survival of screened 'high-risk' subjects.