SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Inducible human photoreceptors for research, development and therapy to prevent blindness

One of the major causes of adult visual impairment and blindness in industrialized countries is the progressive dysfunction and death of photoreceptor cells (PR) as a result of retinal degenerative diseases. Current treatment options are still insufficient to counteract these forms of blindness. The development of many drugs and therapies fail in preclinical stages because the used animal models are suboptimal for translating results from the bench to the bedside. Especially, for testing the transplantation of human PRs, which is currently extensively explored as a treatment option for late stages of retinal degeneration, the biggest bottleneck is the lack of PR material in sufficient quantity and quality. Within the ERC Starting Grant ProNeurons, my team and I have developed a disruptive technology to differentiate human induced pluripotent stem cells (hiPSCs) to PR precursor cells by overexpressing three transcription factors yielding in up to 60% in only 10 days. Our technology allows fast, efficient and unlimited production of PRs essential as testbeds for drug screenings, for further disease research and for photoreceptor replacement therapies. Within the PoC actions, we strive for bringing the induced PRs closer to the market. We will finalize the last product development steps and FTO reviews to define the final products such as PR differentiation kits and/or cryopreserved PRs for research, development and therapy. We will identify and approach industrial exploitation partners for out-licensing or further funding. The final goal of commercializing the induced PRs is to aid the development of new drugs to treat retinal degenerative diseases.
Subvención de capital circulante para PHU «IKAR» Marek Orlikowski — 15796/20

El proyecto tiene como objetivo apoyar a la empresa en la provisión de liquidez y apoyar sus operaciones diarias debido a las dificultades financieras que se produjeron en la empresa como resultado del brote de COVID-19. Ayuda financiera concedida sobre la base del régimen SA.57015.
IPAM-Toolbox: Integrative Protected Area Management in the Alps-Adriatic-Region

The protection of areas and sites is one of the most important instruments of modern, anticipating strategies in nature conservation and planning for sustainable spatial development. Therefore, an enormous increase of number and acreage as well as the number of categories of sites has been registered. The management of these sites has become a challenge for conservation and other sectors, mainly regional planning, since protected area management is related to three dimensions, i.e. the spatial, socio-cultural and economic dimension. Therefore, the planning and managing of protected areas hit very different legal, administrative and technical realities. Besides, the interfaces between regional, national and transnational requirements and solutions must be stringently developed. Within the enlargement process of the EU, different administrative and planning systems should anticipatorily be harmonised in a smooth process.
COOLING GARMENT

A cooling garment, including a garment body (1) and an external-air introducing three-dimensional member (2); and the external-air introducing three-dimensional member (2) includes a base material (2a), a side-wall material (2b) enabling an opening portion to be open during wearing, and an opening portion support material (2c). The three-dimensional member arranged on the garment enables a large amount of external air to be introduced into the internal portion of the garment, even to an exhausting area thereof, especially during movement, thus improving efficiency of air entry and exhaust.
COMPOSITE GRAPHENO-METAL OXIDE PLATELET METHOD OF PREPARATION AND APPLICATIONS

The present invention relates to the method of preparation and applications of composite catalyst of grapheno-metal oxide. Graphene platelets demonstrated to be very convenient support for metal-oxides catalysts. In particular, grapheno-metal oxide platelets can be used advantageously in organic synthesis, solar cells, solar hydrogen production and synthesis of methanol, taking advantage of metal-oxide semi-conductor properties or just of catalytic properties.
THREE-DIMENSIONAL PRINTED METAL-CASTING MOLDS AND METHODS FOR MAKING THE SAME

Methods are disclosed of making metal casting molds and components thereof by the three-dimensional printing process in which an untreated sand is used as the build material and a polymer is used as a component of the binder that is printed onto the build material.
Rolling bearing fault diagnosis based on EEMD and Laplace wavelet

Localized defects in rolling bearings tend to arouse multi-modal impulse responses appearing in vibration signals,these responses affect Laplace wavelet correlation filtering. Here,a novel methodology based on EEMD and Laplace wavelet was proposed to extractal modal parameters of a single modal impulse response. Fistly,multi-modal impulse responses in a vibration signal were decomposed into several single-modal impulse response components with EEMD. Secondly,the needed single-modal impulse response component was chosen from the decomposed components. Thirdly,the chosen single-modal impulse response component was analyzed with Laplace wavelet correlation filtering,and then the fault was diagnosed. The effectiveness of the proposed methodology was demonstrated by analyzing simulated signals and signals of a rolling bearing's inner ring,outer ring and rolling element.
The aging germ cell – biological pathways, risk factors and mechanisms underlying an increasing medical and socio-economic problem

The main objective of GermAge is to understand the devastating decline in germ cell quality during aging, and thus to define the determinants, pathways and risk factors for age-dependent infertility, aneuploidy and inherited diseases. The aging population and the dramatically increasing age of parenthood are associated with grave medical problems, declining reproductive health, and severe consequences for the socio-economic well-being of our societies. These proboems will impact the demographic structure and societal welfare in the European population. Thus the urgent need to understand the biological basis and to identify risk factors and pathways of the steep age-dependent decline in female and male germ cell quality. GermAge will address mostly the aging female gametogenesis known to be most severely affected by aging, but also the important contribution of aging male germ cells to age-related fertility and inheritance problems. The decay of key chromosome proteins such as cohesins, the failure of quality control mechanisms such as the spindle assembly checkpoint, and the mutation load in aging spermatogonial stem cells are among the highly synergetic research topics of GermAge. Mouse and human germ cells will be analyzed by high-end and innovative techniques. The expected insights will eventually lead to much improved diagnostics in various reproductive medicine procedures such as quality control of germ cells frozen for delayed in vitro fertilization, development of new biomarkers for oocytes, risk assessment for inherited diseases including aneuploidie in carriers of specific mutations, and prognosis based on individualized genomics on age-related quality decline of oocytes and spermatocytes. We also expect that our findings will raise awareness of the risks associated with postponing parenthood, leading to a much-needed prioritization on the public health agenda.
Roberta Pergher, Ã¢â‚¬Å“Dalle Alpi allÃ¢â‚¬â„¢AfricaÃ¢â‚¬Â

all'Impero ottomano e poi organizzate nella colonia di Libia.
DENTAL HYGYENE-BRUSHING CONSTRUCTION

A brushing construction, particularly for oral or dental hygiene, comprises a brushing head which is removably coupled to a handle by a screw engagement means, the brushing head including a brushing head body having a threaded seat and a lug on which are engaged a plurality of brushing bristles arranged according to a spiral or spoke arrangement in either a cylindric or conic configuration; said brushing head being adapted to be applied to an end portion of the handle by screwing the body on an end portion of the handle, which, to that end, comprises a thread adapted to be threadably engaged in the threaded seat of the brushing head body.
KELLY VALVE

A kelly valve for placement in a tubular drillstring has an inner cage, which holds a valve ball, lower valve ball seat and other valve components. A valve stem connected to the valve ball extends through a valve stem sleeve, positioned in an opening in the wall of the main body of the kelly valve. A thrust bearing of a low friction material, preferably of polyether ether ketone (PEEK), is positioned between the valve stem and the valve stem sleeve. A port in the valve ball seat permits pressure below the kelly valve to bypass a seal and act on the inside of the valve ball. A circumferential notch in the valve ball seat accommodates a circular spring, and prevents complete compression of the spring when the valve ball seat contacts an interior shoulder in the inner cage.
Indigenous Methodologies: Suggestions for Junior Researchers

Indigenous methodologies in geography have recently been developed to decolonise Western dominated paradigms. It has been argued that research which does not benefit Indigenous communities should not be conducted. However, Indigenous methodologies are not taught in many post-secondary institutions. Therefore, when they pursue Indigenous topics, many junior researchers are self-taught in these methodologies. However, these methodologies cannot be defined simply and they are too diverse to be learnt in a short period. In Japan, Indigenous peoples are not widely recognised and research on contemporary Indigenous issues is limited. The concept of Indigenous methodologies is rarely discussed. Because of this, Japanese researchers rarely identify their research as adopting an Indigenous methodology. Indigenous researchers are thereby discouraged from pursuing Indigenous methodologies. Furthermore, a methodology or a thesis statement used by researchers to reflect Indigenous perspectives often gets little support from Indigenous peoples. My master's research on the Ainu mirrored this situation. While Indigenous methodologies remain difficult to learn, junior researchers should not be discouraged from this form of engagement. Practical suggestions are therefore necessary to encourage their use and application. Based on my experience, I suggest that researchers approach Indigenous communities from a learning perspective. This would encourage open-mindedness and sensitivity. Researchers should also be prepared and willing to refine their research questions and to continue their literature searches after their fieldwork is completed. These strategies could limit misinterpretation and exploitation of Indigenous knowledges and peoples.
TDI OU PROFESSOR? TRAJETÓRIAS E IDENTIDADES DE PROFISSIONAIS DA EDUCAÇÃO INFANTIL EM UMA CRECHE NO MUNICÍPIO DE CUIABÁ

O presente artigo é resultado de uma pesquisa realizada a partir do Curso de Especialização em Docência na Educação Infantil do Instituto de Educação da Universidade Federal de Mato Grosso – UFMT. Tomou como temática de pesquisa as identidades profissionais dos Técnicos em Desenvolvimento Infantil – TDIs, que atuam no município de Cuiabá. A pesquisa teve como intenção buscar repostas para a seguinte questão: Como estão demarcados os percursos e as identidades profissionais dos Técnicos em Desenvolvimento Infantil - TDIs que atuam em uma creche de Cuiabá? Para buscar respostas ao problema anunciado, elegi como objetivo geral compreender, discutir e refletir sobre os percursos pessoais e formativos que levaram os TDIs à educação infantil, bem como os fatores que os levaram à permanecer na profissão destacando elementos das respectivas. Ao realizar a presente pesquisa tive a oportunidade de fazer uma observação a respeito da profissão de TDI do Município de Cuiabá, suas ansiedades, as leis que regulamenta a profissão, as políticas públicas para a profissão de TDI e um grande questionamento que ainda os profissionais tem consigo, porque esses profissionais não são considerados professores visto que os mesmo planejam e executam as mesmas tarefas que um professor em sala de aula alem do cuidar. A pesquisa apontou que os TDIs mesmo tendo clareza da sua condição profissional de técnicos, se consideram professores mediante as funções que exercem nas creches; buscaram qualificação profissional para atuarem como professores e se revelam muito comprometidos com a perspectiva de desenvolverem um trabalho de educadores para além da função de cuidadores que tradicionalmente lhes foi atribuída.
Process for the preparation of a polyimide film.

A polyimide film essentially consisting of polyimide having recurring units of the formula ( I ): <CHEM> which has a density of 1.335 to 1.390 g/cm<3> at 23 DEG C and/or a refractive index of 1.605 to 1.680 at 23 DEG C in the direction of thickness and is transparent; and a preparation process of the polyimide film by extruding the polyimide having recurring units of the above formula ( I ) throught a common melt-extrusion process, casting an a chill-roller to obtain an unstratched film, uniaxially or biaxially stretching the unstretched film to cause molecular orientation, and successively setting the stretched film through heat-treatment; is disclosed.
Geometric morphometric 3D shape analysis and covariation of human mandibular and maxillary first molars

Dental casts of 160 Greek subjects (80 males, 80 females) were scanned by a structured-light scanner. The upper and lower right first molar occlusal surface 3D meshes were processed using geometric morphometric methods. A total of 265 and 274 curve and surface sliding semilandmarks were placed on the upper and lower molar surfaces, respectively. Principal component analysis and partial least square analysis were performed to assess shape parameters. Molars tended to vary between an elongated and a more square form. The first two principal components (PCs), comprising almost 1/3 of molar shape variation, were related to mesiodistal-buccolingual ratios and relative cusp position. Distal cusps displayed the greatest shape variability. Molars of males were larger than those of females (2.8 and 3.2% for upper and lower molars respectively), but no shape dimorphism was observed. Upper and lower molar sizes were significantly correlated (r(2) = 0.689). Allometry was observed for both teeth. Larger lower molars were associated with shorter cusps, expansion of the distal cusp, and constriction of the mesial cusps (predicted variance 3.25%). Upper molars displayed weaker allometry (predicted variance 1.59%). Upper and lower molar shape covariation proved significant (RV = 17.26%, P < 0.0001). The main parameter of molar covariation in partial least square axis 1, contributing to 30% of total covariation, was cusp height, in contrast to the primary variability traits exhibited by PC1 and PC2. The aim of this study was to evaluate shape variation and covariation, including allometry and sexual dimorphism, of maxillary and mandibular first permanent molar occlusal surfaces.
Rethinking future infrastructure networks

Launching a European long-term ambition and initiative to increase the overall performance of multimodal transport infrastructures, the REFINET CSA intends to 1) create a sustainable network of European and international stakeholders’ representatives of all transport modes and transport infrastructure sectors, 2) deliver a shared European vision of how to specify, design, build or renovate, and maintain the multimodal European transport infrastructure network of the future along with innovative processes so as to enhance the effectiveness of the sector, and 3) elaborate a Strategic Implementation Plan with a comprehensive set of prioritised actions to made the REFINET vision a reality – as well as providing private and public decision makers with a set of up-to-date recommendations and guidelines (including good practices and lessons learnt) for strategic actions and required levels of cooperation between all stakeholders. REFINET will consider two complementary scenarios, namely maintenance and upgrading of existing transport infrastructures, and development of new transport infrastructures. REFINET will contribute to create a European-wide consensus on where to focus in terms of research and innovation to improve the productivity of the assets (reducing maintenance costs, extending the life span…) and reduce drastically traffic disruptions of transport flows from inspection, construction and maintenance activities, and to accommodate increasing/changing traffic demand. Thus, REFINET will pave the way to enhanced technology integration and transfer and mass-market development for innovative materials, components, systems and processes supporting the pan-European generalisation of advanced multimodal infrastructures, handling the demand within various industrial sectors and help match the EU-2020 Strategy, and achieve goals of main stakeholders. The REFINET consortium is made of 8 partners from 5 European countries (Spain, France, Italy, Belgium, United Kingdom).
Detection of vocal disorders based on phase space parameters and Lyapunov spectrum

Abstract Previous studies have shown that the underlying process of speech generation exhibits nonlinear characteristics. Since linear features cannot represent a nonlinear system thoroughly, this paper employs new sets of non-linear measurement for assessing the quality of recorded voices. Such measurement could be exploited for implementing efficient and convenient systems for diagnosing laryngeal diseases without using invasive methods. Three sets of features based on mutual information, false neighbor fraction, and Lyapunov spectrum are investigated to this end. Furthermore, distributions of the proposed features and their discriminative property are investigated. Moreover, the described procedure benefits from the synergy between different concepts of pattern recognition. First, a genetic algorithm (GA) is invoked to find a-near optimum subset of features. Second, linear discriminant analysis (LDA) is applied to remove remaining redundancies and correlations between selected features. Finally, support vector machine (SVM) is employed for learning decision boundaries. Sensitivity and specificity of 99.3% and 94% respectively were achieved in the simulation results.
Net analyte signal standard addition method (NASSAM) as a novel spectrofluorimetric and spectrophotometric technique for simultaneous determination, application to assay of melatonin and pyridoxine

In this work a new modification of the standard addition method called "net analyte signal standard addition method (NASSAM)" is presented for the simultaneous spectrofluorimetric and spectrophotometric analysis. The proposed method combines the advantages of standard addition method with those of net analyte signal concept. The method can be applied for the determination of analyte in the presence of known interferents. The accuracy of the predictions against H-point standard addition method is not dependent on the shape of the analyte and interferent spectra. The method was successfully applied to simultaneous spectrofluorimetric and spectrophotometric determination of pyridoxine (PY) and melatonin (MT) in synthetic mixtures and in a pharmaceutical formulation.
NVMcached

As byte-addressable, high-density, and non-volatile memory (NVM) is around the corner to be equipped alongside the DRAM memory, issues on enabling the important key-value cache services, such as memcached, on the new storage medium must be addressed. While NVM allows data in a KV cache to survive power outage and system crash, in practice their integrity and accessibility depend on data consistency enforced during writes to NVM. Though techniques for enforcing the consistency, such as journaling, COW, or checkpointing, are available, they are often too expensive by frequently using CPU cache flushes to ensure crash consistency, leading to (much) reduced performance and excessively compromised NVM's lifetime. In this paper we design and evaluate NVMcached, a KV cache for non-volatile byte-addressable memory that can significantly reduce use of flushes and minimize data loss by leveraging consistency-friendly data structures and batched space allocation and reclamation. Experiments show that NVMcached can improve its system throughput by up to 2.8x for write-intensive real-world workloads, compared to a non-volatile memcached.
Reduced Crew Operations

While most modern commercial airplanes are flown with two pilots, long haul flight operations
require augmented flight crews. While the normal crew complement conducts the takeoff, climbout
and initial en route segments, additional pilots are on-board. These ‘relief’ pilots will be rested
and ready to take over the flying duties later in the flight. Flight duty times and preand postflight
rest requirements currently require multiple flight crews per airplane in order to maximize
utilization of the airplane.
Advances in intelligent systems, airspace modernization, human factors, and data links are raising
the possibility of safely and efficiently operating commercial airplanes with reduced flight crews.
As applied to long haul commercial flights, such Reduced Crew Operations (RCO) concepts may
include periods of flight where there is only one pilot in the cockpit while other pilot(s) are taking
prescribed rest periods. In the RCO concept, the normal flight crew complement (for example,
captain and first officer) are in the cockpit for critical flight phases such as takeoff and landing and
then alternate flying and resting during cruise. In the event of abnormal operations or an in-flight
emergency, the resting pilot can be alerted and called to the flight deck.
This paper examines the operational and regulation aspects of Reduced Crew Operations. An impact
analysis of the applicable US Federal Aviation Regulations, particularly Part 117 Flight and
Duty Limitations and Rest Requirements: Flight Crew Members, and Part 121 Operating Requirements:
Domestic, Flag, and Supplemental Operations is presented. This paper provides a summary
of the research into RCO concept of operations, including research jointly conducted by NASA and
Rockwell Collins. Based on the regulation impacts and the studies, this paper identifies the present
operational, procedural, and technical challenges that must be addressed to safely implement Reduced
Crew Operations.
Information Society Network

ISN partnership held 8 seminars in different partner cities,
creating an opportunity for each partner to showcase good
practice examples. These examples acted as a catalyst to
generating debate and material that the expert could use to
draw conclusions.
The seminars covered for each of the four sub themes:
1. E-Democracy and Empowerment – ICT can be used
to encourage citizens to participate in decision making in
their community. ICT can increase the choice of channels for
communicating with citizens and improve the consultation
process.
2. Citizen’s Access – government and public authorities are
increasingly using ICT to provide a better service at a lower
cost. This fact can have a negative effect due to the exclusion
it can cause for those members of society without access.
3. ICT and Business Development – business can become
more efficient and profitable through the use of ICT.
4. Culture, E-Content and Citizenship – ICT can help to
promote the inclusion of different social groups and through
cultural activities it is possible to engage with local citizens.
The case study approach adopted by ISN allowed the analysis
to highlight interesting projects, a large number of which
can be found in the network final report.