SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
C-Gmp compliance of c-stem, an ipsc based cell therapies production technology

Scaling-up cell therapy manufacturing provides many benefits: the capacity to replace failing tissues in patients suffering from incurable chronic or degenerative diseases, affordable treatments and the economic viability of the development of cell therapies for rare diseases. The baseline of TreeFrog Therapeutics (TFT), “Cell Therapy for All”, encapsulates this vision.TFT has already obtained outstanding results with its C-StemTM stem cell culture technology, fully scalable and allowing a high cell multiplication factor.
The cell therapy market has boomed since 2012. In 2018, 1,028 clinical trials were underway according to the Alliance for Regenerative Medicine and big pharmas invested €6.2bn in cell therapy programs. The FDA anticipates to approve « 10 to 20 cell and gene therapy products a year » by 2025.
A critical bottleneck remains for the cell therapies that will reach the market within 5 to 10 years: the industrial production of human induced pluripotent stem cells, the raw material for cell therapies. Current manufacturing models do not meet the standards of regulatory authorities and healthcare systems in terms of safety, cost, volume and lead time. With C-StemTM, TFT is in the best position to become the global supplier of stem cells for cell therapy’s industry.
Tailored for cost-killing mass-production of stem cells, while defining a new quality standard for cellular products, C-StemTM needs to be certified for “Good Manufacturing Practices” (GMP) to be used in clinical settings and capture its market. This project requires, within 24 months, to develop a GMP encapsulation device, to replace non-compliant materials, while developing relations with EU/US regulatory agencies and clients from the pharmaceutical industry.
TFT has a “go-global” strategy and aims at leading its market within 7 years. Funding from the H2020 Instrument PME Phase 2 would secure the project and consolidate TFT on the financial level, a key element to outpace non-european players.
Impacto fiscal de la descarbonización del transporte en Costa Rica y opciones de política para manejarlo

resolverse amistosamente se someterá a arbitraje de conformidad con las reglas de la CNUDMI (UNCITRAL).El uso del nombre del BID para cualquier fin distinto al reconocimiento respectivo y el uso del logotipo del BID, no están autorizados por
Distrofia muscolare oculofaringea

La distrofia muscolare oculofaringea è una miopatia progressiva a trasmissione autosomica dominante caratterizzata dall’insorgenza tardiva dei segni clinici, il più delle volte dopo i 50 anni. Si tratta di una patologia rara, la cui prevalenza è inferiore a 1/100 000 in Francia. I primi sintomi sono costituiti da una ptosi progressiva simmetrica che causa una contrazione compensatoria del muscolo frontale e una disfagia. L’evoluzione è verso la comparsa di una debolezza dei muscoli prossimali, in particolare a livello della cintura pelvica. Il gene responsabile è stato localizzato sul cromosoma 14 (poly A binding protein nuclear 1 [PABPN1]). Esso codifica una proteina nucleare che svolge un ruolo nella maturazione e nella stabilità degli acidi ribonucleici messaggeri (mRNA). La malattia è la conseguenza di un’espansione anormale e stabile di una ripetizione di triplette (GCN) nell’esone 1 del gene PABPN1. Questa espansione, la cui dimensione normale è di dieci ripetizioni, è aumentata in modo anomalo tra 11 e 18 ripetizioni. La proteina anormale risultante è responsabile della presenza di inclusioni tubulofilamentose osservate nei nuclei delle fibre muscolari del paziente e patognomoniche della malattia. Benché non esista un trattamento specifico per questa patologia, la chirurgia della ptosi, la miotomia e la dilatazione cricofaringea migliorano significativamente la qualità di vita di questi pazienti.
A device for crop processing

A device for crop processing. The device is autonomously movable, and is provided with a mowing unit (7) for mowing the crop, with a rake unit (8) for raking mown crop, and with a tedder unit (9) for tedding mown crop. The device is further provided with a position-determining system (3) for determining the position of the device, with a boundary-detecting system (4) for detecting a boundary of mown crop, and with a control device (5) for controlling the device with the aid of data from the position-determining system and/or the boundary-detecting system. <IMAGE>
Review of Clinical Researches about Korean Medicine Treatment on Language Disorder of Cerebral Palsy

Objectives: The purpose of this study was to obtain some understanding about Korean medicine treatment on language disorder in cerebral palsy for future practice and the research, from the clinical studies. Methods: The literature was searched using the database-China Academic Journals (CAJ). Clinical studies of Korean medicine treatment for language disorder in cerebral palsy, including Randomized controlled trial (RCT), case control study, case series, case report were analyzed. Results: Fifteen Clinical studies met our inclusion criteria; One case study and six case series, one non-randomized controlled trial and seven RCTs. Acupuncture treatment, especially Head acupuncture, was the major treatment for language disorder of cerebral palsy in clinical studies, as it was used in fourteen studies. Acupoint massage, tuina, and acupoint injection were employed as treatment methods in the studies. Acupuncture treatment was used for language disorder of cerebral palsy combined with language therapy and other rehabilitation treatment in many studies. The effectiveness in the treatment groups, regardless of treatment methods, was higher than that of control group in all RCT studies. Conclusions: The results of this study could be used in the practice and the future study about language disorder of cerebral palsy.
Project of a cogeneration system using biogas

Brazil has been among the countries with the cleanest energy matrix in the world. The country showed high growth rates on the economy during the first years of the 21st, which brought to a rapid demand on energy supply. The situation got worser with long dry seasons, resulting on the commissioning of several thermoelectric plants. In the sugar-alcohol sector, the cogeneration became essential. In this context, the use of biomass for the generation and burning of biogas shows great potential in the production of electricity and heat. The discussed study involves the design of a biogas cogeneration system for the Federal University of São Carlos. The considered biomass originates from the campus itself and is composed of organic waste. The system consists of a modified diesel engine, accoupled to an electric generator and three heat exchangers. The monthly production of electricity is 7,7 MWh with a power of 30 kW. The monthly production of thermal energy is 9,8 MWh with a power of 37,6 kW. The costs are quoted adding up to R$ 162,877.00 for the complete system. The annual savings with the system is estimated at R$ 91,126.40, reaching an amortization time of one year and ten months.
OPÇÕES METODOLÓGICAS EM AVALIAÇÃO: SALIÊNCIAS E RELEVÂNCIAS NO PROCESSO DECISÓRIO

The educational assessment has been shown as an untidy controversial issue in plans, programs and educational projects in Brazilian context. There are numerous theoretical propositions available in the literature, however, the practical operation of evaluative practices are not being enough. The assessment process has been considered, many times, as a simple proceed with strong appeal instrumental. The extension of theoretical proposal about assessment open space for discussion between two different ideological ideas: assessment as control and assessment as emancipator process. The text brings as guideline the models that have had a major penetration in our midst and that still are present in the Brazilian educational system
Feet on the ground: engineering geology past, present and future

Engineering geology has a long and rich heritage and the UK has been in the vanguard of the development of the subject as a distinct discipline, with the first book on the subject being published in London in 1880. Since then, engineering geology has been applied to projects around the world and engineering geologists have become core members of planning, investigation, design and construction teams in the civil engineering and mining industries. However, in the past few decades we have seen numerical analyses increasingly being accepted as the answer to all geotechnical design questions, although as engineering geologists we are used to dealing with natural materials and processes and recognize that their inherent variability cannot always be reduced to a simple numerical value. Consequently, how do we ensure that any proposed construction works in civil engineering or mining take full account of this variability and the uncertainties that result? To enable engineering geologists to understand and describe these uncertainties are there fundamental skills that define an engineering geologist and, if so, how can these skills be taught or acquired? Also, in a world dominated by readily accessible data that can be downloaded and analysed for so many planned development sites, how important are the field techniques of observation and mapping that an older generation of engineering geologists, including the author, considered their defining skill? Concentrating on the role of engineering geology in relation to civil engineering, these are amongst the questions explored in this paper, leading to observations as to how the profession might develop in the future in order to meet the needs of society.
Integrated test environment for combinatorial testing

In this paper we propose an integrated test environment for combinatorial testing and discuss its realization at macro level. We describe the entities that make up the integrated test environment and their interaction, high-lighting the combinatorial test aspects. The proposed environment can be used for the automated as well as manual testing. Test tools supplied by research institutions and commercial tool vendors need to be integrated to realize the test environment proposed in this paper. The proposed system is theoretical in nature which can be embraced by large scale industrial and research projects to achieve an efficient integrated environment for combinatorial testing. This in turn can aid in the adoption of combinatorial testing to achieve the desired quality improvements in the products.
Europe enabling Smart Healthy Age-Friendly Environments

According to World Health Organization (WHO) "making cities and communities age-friendly is one of the most effective local policy approaches for responding to demographic change”. However, regional initiatives still lack alignment between absolutely complementary policy areas such as health, social affairs, territorial sustainable development, employment and wellbeing. This silo approach restrains the creation, availability and large-scale adoption of age-friendly solutions across Europe. Known is also the gap between technological developments and end-users real needs and expectations. Therefore, policy alignment, collaborative efforts and sharing of good practices will be keystones to add better quality of life, more inclusive and sustainable health and social care systems and citizen’s access to the services.

The EU_SHAFE project will improve policies and practices in 7 European regions by developing a comprehensive approach to Smart Healthy Age-Friendly Environments (SHAFE). Through a 'learning by sharing' methodology, this robust multi-disciplinary and intersectoral consortium will build a four-helix European community to exchange experiences and practices to improve multilevel policy instruments. The consortium will create a cooperative, inclusive ecosystem between public authorities, European networks and user’s associations, embedding their experience and skills with research & design knowledge from academia and SMEs for the growth of community-based services and “ageing at home” around Europe. 
• EU_SHAFE will Invest in policy design and adaptation of regional instruments derived from ETCF (R&I priorities) and ESF (Social Inclusion), through the creation of a large Euro-local network of stakeholders that will work together in ecosystems towards a common model – a White Paper on SHAFE.
• Select and re-design concrete and scalable interventions in the area of social innovation for SHAFE, that may be implemented as realistic innovative models for the future.
Analyse de l’évolution de la disponibilité lexicale d’un échantillon d’élèves apprenant le FLE durant le cycle secondaire en Espagne

Si les avancées en termes de disponibilité lexicale ne sont que très récentes, depuis ces dernières années, les recherches dans ce domaine se sont considérablement approfondies. Bien que de telles recherches foisonnent dans le monde hispanique, ce travail s’inscrit, modestement, dans cette lignée et revient à ses origines. En effet, les recherches sur le concept de disponibilité lexicale ont vu le jour en France. En outre, ce projet expérimental propose d’établir un état des lieux de l’évolution du vocabulaire disponible en langue étrangère grâce à l’analyse d’un corpus réalisé auprès d’élèves de langue maternelle espagnole apprenant le français comme seconde langue étrangère en Espagne. Notre expérience avec un échantillon composé de 294 élèves met l’accent sur les possibilités que peuvent offrir ce type d’étude à l’enseignement du vocabulaire pour l’élaboration de supports en fonction des besoins d’apprentissage plus axés sur la qualité de l’apprentissage dans le temps. En effet, la courbe reflétant l’évolution du bagage lexical n’est pas toujours croissante mais plutôt irrégulière. Ce qui confirmerait peut-être d’autres études sur le fait que l’apprentissage n’est pas linaire mais en spirale, fait d’allées et venues.
Research on Philosophical Issues of Strategic Emerging Industries

It is very necessary to study the basic connotation,main feature and law of development of strategic emerging industries from the perspectives of philosophy of industry.Strategic emerging industries realize industrial innovation through the optimization combination of emerging industry and strategic industry.The main characteristics of strategic emerging industries is the innovation drive of core technology,market orientation of import substitution and industrial policy support of the long-term stability.In the post-crisis era,we should seize the opportunity to adjust and optimize the industrial structure,drive industrial innovation with science and technology innovation.We should select,cultivate and develop correctly strategic emerging industries suitable for the national conditions which become an important force to guide the future economic and social development.
INNOVATION FOR SOCIETAL CHANGE

The PEOPLE partnership is engaged to explore the opportunities for new employment and ways of reinforcing cohesion and well-being in the context of demographic and societal changes faced by European regions. The nascent trends are the ageing population, new family structures, legal/illegal immigration and the emergence of new vulnerable groups, all of this impacting on the interrelation between people, generations and across countries. The renewed Lisbon Strategy for Growth and Jobs and Cohesion Policy 2007- 2013 is promoting innovation as a possible way of finding appropriate solutions to many of the demographic and societal challenges currently occurring in the EU. Initiatives such as the Regions for Economic Change illustrates that innovation has been acknowledged as a cohesion policy priority by the Member States. The PEOPLE partners are proposing to launch a joint regional PEOPLE Action Plan to deliver innovation on societal change at regional level.
The PEOPLE project comprises of a set of regional activities (Communication campaign, International conferences, Study visits, Sub-projects) and will deliver outputs (Transfer of good practices, Policy recommendations, PEOPLE Information System) under six sub-objectives tackled by the PEOPLE mini-programme; 1- Social and e-inclusion. 2- Silver economy. 3- Civil society capacity building. 4- ICT for Health and dependency. 5- Social entrepreneurship. 6- Work-life balance. The proposed Action Plan is linked to the regional strategic planning and will raise awareness on the opportunity for employment, growth in the context of social cohesion amongst regional policy makers and other players of the civil society. The Information Society has clearly the potential to distribute more equally knowledge resources and to offer new job opportunities, also by overcoming the traditional barriers to mobility and geographic distance. PEOPLE will benchmark and support the creation of new schemes and
policies to promote self-employment and home business start-up, e-health or e-inclusion, social entreprises and other advanced mechanisms to foster local and regional services for social service based companies. Organising work differently, adapting work patterns to new societal demands has a high impact on people's well-being, self-confidence and on the cohesion of society. Developing the adaptability of regions to respond to these societal changes will require new policies, new services, new skills and mechanisms in place to allow change. This will be done better and quicker through the transfer of good practices and all PEOPLE partners are committed to tackle these common societal challenges as demonstrated by their participation in IIIC RFO GROW and project REVOS. PEOPLE mini-programme will provide a framework for developing and sharing innovative tools and methodologies, the identification and transfer of good practices and the best ways of influencing policy makers in this field.
Risk of Low-Level Ionizing Radiation from Medical Imaging Procedures

Medical imaging procedures with x-ray, computed tomography (CT) and nuclear isotopes use ionizing radiation.1–4 On the other hand, ultrasound and magnetic resonance imaging (MRI) do not. When biological tissues are exposed to radiation, the effects are related to the type of radiation and the amount absorbed. Units of absorbed dose are grays (Gy) (joules/kilogram). One rad (radiation absorbed dose) is 0.01 Gy.5 As not all types of radiation affect tissue the same, the equivalent dose (measured in Sieverts) takes this into account. X-ray, CT, and gamma ray radiation have a “weighting factor” of 1.0, therefore with these medical procedures 1 Gy = 1 Sv. Medical imaging doses are usually measured in units of milliSieverts (mSv). In addition, one REM is 0.01 Sv (10 mSv). An average exposure from natural background radiation in the United States for an individual is ∼3–5 mSv/year.5–8 Also, a small amount of radiation exposure occurs with tobacco, the domestic water supply, building materials, and to a lesser extent televisions, and computer screens.9 The usual radiation dose of a chest radiograph is 0.02–0.1 mSv.10–12 Representative radiation doses for other radiological studies are shown in Figure 1.13–17 These medical studies contribute up to 20% of the total annual radiation exposure to the population of the United States.18 The National Research Council’s Committee to Assess Health Risks from Exposure to Low Levels of Ionizing Radiation has published their most recent report, the BEIR VII Report.19 The purpose of this report is to advise the U.S. Government on the relationship between exposure to ionizing radiation and human health. The BEIR VII Report describes a cancer risk model (linear no-threshold model) in which cancer risk diminishes proportionately to diminishing radiation exposure.
Crystal Structure of a Trimeric Sodium/Aspartate Symporter with Protomers in Mixed Outward- and Inward-Facing States

GltPH is a bacterial trimeric sodium-coupled aspartate transporter homologous to human glutamate transporters that catalyze the uptake of the neurotransmitter from the synaptic space. Crystal structures of GltPH in the outward- and inward-facing conformations suggest that a “transport” domain carries ions and aspartate across the membrane by sliding along an immobile “trimerization” domain. To explore the range of motions of the transport domain, we have designed pairs of cysteine mutations, which upon cross-linking capture the transport domain in distinct positions relative to the membrane and the trimerization regions. Remarkably, cross-linking results suggest that the transport domain is able to move significantly further towards the cytoplasm compared to what could be inferred from the previously determined structure of the inward-facing state. To further understand the structural changes in the transporter, we have crystallized and determined a low-resolution structure of one of these cross-linked mutants. Strikingly, we found that the cross-link broke and that the three protomers relaxed to an assortment of inward- and outward-facing conformations. Two monomers show conformations nearly identical to that of the published inward-facing state. The third protomer assumes an outward-facing conformation. Remarkably, this position of the transport domain is significantly more inward compared to the previously reported outward-facing conformation. Combined, our data suggest a highly dynamic nature of the transport domain, which explores a range of orientations relative to the trimerization domain. Furthermore, we provide the structural evidence supporting the hypothesis that the three protomers function independently within the trimeric transporter. Finally, because the two inward-facing protomers are not constrained by cross-links, we conclude that the observed position of the transport domain likely corresponds to an energetic minimum.
European disunion : between sovereignty and solidarity

Introduction Jack Hayward and Rudiger K.W. Wurzel 1. Union without Concensus J.Hayward Part I Enfeebled Democratic Legitimacy 2. The Difficult Emergence of a European People Michael Bruter 3. A Nascent Transnational Civili Society Elizabeth Monaghan 4. An Obdurately National Party Politics Robert Ladrech Part II Institutional Deadlock: A Surfeit of Would-be Leaders 5. National Governments, the European Council and Councils of Ministers: A Plurality of Sovereignties. Member State Soverreigns without an EU Sovereign Jack Hayward 6. The European Commission Bureaucracy: Handling Sovereingty throught the Back and Front Doors Edward C. Page 7. The Empowerment of Parliaments in EU Interrogations: Victims or Victors? Maja Kluger Rasmussen 8. National Courts and European Union Courts Patrick Birkinshaw 9. Defending the Euro: Unity and Disunity among Europe's Central Bankers David Howarth 10. Territorial Flexibility Michael Keating Part III Policy Divergences and Convergences 11. Foreign and Defence Policy: The Sovereignty Obsession and the Quest for Elusive Solidarity Anand Menon 12. Economics and Monetary Disunion? Kenneth Dyson 13. Social and Labour Market Policy: The (Re-)Emergence of Competitive Tension Nick Parsons 14. From Environmental Disunion towards Envirnomental Union?: Rudiger K.W. Wurzel Part IV Adjusting to the REceding Sovereignty of Member States 15. A Contested Franco-German Duumvirate William Paterson 16. Opt-out: Britain's Unsplendid Isolation Philip Norton 17. The Nordic Countries: The Causes and Consequences of Variable Geometry Nick Sitter 18. Southern European and the 'Trade-off': Architects of European Disunion? Martin J. Bull 19. The Central and East European Countries: From Weak Latecomers to Good Citizens of the Union Vesselin Dimitrov Conclusion: European Disunion: Between Solidarity and Sovereignty Rudiger K.W. Wurzel and Jack Hayward