SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Femtosecond-Assisted Keratopigmentation Double Tunnel Technique in the Management of a Case of Urrets-Zavalia Syndrome

To describe the successful use of a double intrastromal tunnel femtosecond-assisted keratopigmentation technique to manage a case of unilateral Urrets-Zavalia syndrome.A 33-year-old man was referred with a history of trauma in his right eye due to a labor-related accident. Because of myopic anisometropia, he had been previously implanted with an angle-supported phakic intraocular lens. The patient presented iris atrophy and a fixed dilated pupil. He complained of severe and incapacitating photophobia, glare, and decreased vision. To obtain a complete iris replica, the surgery involved creation of double keratopigmented intrastromal tunnels using femtosecond laser and micronized mineral pigments. The deepest layer was stained black first and then the superficial layer was stained with a contoured greenish blue-gray color, which matched the contralateral eye.In the immediate postoperative period, the patient reported a complete elimination of photophobia associated with the corrected distance visual acuity improvement. A very adequate cosmetic outcome was also achieved. Stability was observed during the 12-month follow-up.A femtosecond-assisted keratopigmentation technique using 2 pigmented intrastromal tunnels to achieve an intracorneal pigmented replica of the iris was effective in improving the patient's severe visual function disability and cosmetic appearance. To the best of our knowledge, this is the first report of severe visual function disability caused by atrophic iris and a fixed dilated pupil treated with double intrastromal layers of keratopigmentation by means of femtosecond-created tunnels.
Comparative genomics of sugar-eating bats: implications for the genetics of glucose metabolism and diabetes

Diabetes and impaired glucose tolerance are major threats to human health. These conditions are linked to obesity and poor diet but also have major genetic components. To date, most knowledge of the genetics of sugar metabolism and diabetes comes from epidemiological studies of humans and lab studies of mice. However, novel powerful insights might also be obtained by studying novel non-model species that have undergone evolutionary adaptations for subsisting on high sugar diets. Among mammals, bats are unique in their range of dietary specialisations with up to eight lineages having independently evolved nectar-feeding (‘nectarivory’). Yet how these bats are able to survive on high sugar diets, and regulate their blood sugar to resist the damaging effects of glucose toxicity, is not understood. To discover the genes and mutations that confer these abilities in bats, we will use state-of-the-art cross-species targeted genome-capture to obtain thousands of orthologous sequences from all nectar-feeding fruit bats and their non-nectar feeding relatives. We will first identify genes showing signatures of molecular adaptation for each key branch associated with the acquisition of nectar feeding. Second, we will compare these sets of genes, and their respective protein-protein interaction networks, to determine whether divergent bats have evolved nectarivory by recruiting the same genes and pathways. Our findings will improve our understanding of how natural selection has driven dietary specialisation in mammals, and will also shed light on whether related metabolic diseases arise via mutations occurring at the same sites, or instead arise from the disruption of more evolutionarily conserved sites that have not been subject to molecular adaptation.
Functional electrical contacts to two-dimensional materials with tunable interfacial oxides

Two-dimensional (2D) van der Waals (vdW) materials are promising for future nanoelectronic devices. However, their performance is often hampered by the presence of a large number of defects at metal/2D material interfaces. The project ProTOC will extend the applications of atomic layer deposition (ALD) to engineer functional electrical contacts in 2D nanoelectronic devices using interfacial transition metal oxides (TMOs) of controlled stoichiometry and electronic properties. ALD-grown TMOs, vanadium and titanium oxides, are explored as interfacial layers that are vdW-bonded to 2D material MoS2 on one side and chemically bonded to the metal electrode one the other side. ALD allows for precise control of the oxide composition in order to tune electronic properties, such as work function, dielectric constant, and defect concentrations. The electronic properties of ultrathin ALD-oxides of different compositions and their complex interactions with 2D materials, which in turn affect transport, will be investigated in a combined effort using 2D field-effect transistor (FET) transport measurements, spectroscopic methods, and scanning probe microscopy techniques. The band alignment at the contacts can be adjusted by changing the composition of the ALD-grown layers, which may provide a new route to engineering desired contact behaviour over a broad range from rectifying or low resistance ohmic, depending on the end application. This contacting scheme will be exploited to achieve both p- and n-type conductance in MoS2 FETs, which is key for logic applications and difficult to achieve with 2D materials. This project will benefit from the complimentary knowledge and experience of researcher, who is an expert in device design, fabrication, and advanced scanning probe methods, as well as host, who provides unique capabilities and expertise in materials growth by ALD and the spectroscopic characterization of complex oxide films in the context of devices.
Experimental investigation on the shear capacity of prestressed concrete beams using digital image correlation

Abstract Despite more than a century of continuous effort, shear still remains one of the few areas of research into fundamentals of the behavior of concrete structures where dispute remains amongst researchers about the mechanisms that enable the force flow through a concrete member and across cracks. Due to our incomplete understanding and the brittle failure modes associated with shear, current codes of practice tend to propose highly conservative shear design provisions. This paper investigates the shear capacity and mechanical behavior of prestressed concrete beams. The results of 9 full-scale I-shaped prestressed concrete beams subjected to a four-point bending test until failure are presented. Two stereo-vision digital image correlation (DIC) systems were used to discretely measure three-dimensional displacements and in-plane deformations in both zones where a shear force exists. A numerical technique has been adopted to generate optimized patterns for DIC and the resulting speckle pattern was applied onto each specimen using a stencil printing technique. Using the sectional shear design procedure found in Eurocode 2, a severe underestimation of the experimentally observed shear capacity was found. Direct strut action was the main bearing mechanism of the reported prestressed concrete members with shear reinforcement whereas the presented specimens without shear reinforcement failed when the principal tensile stress reached the tensile strength limit.
On ideal equal convergence

Abstract We consider ideal equal convergence of a sequence of functions. This is a generalization of equal convergence introduced by Császár and Laczkovich [Császár Á., Laczkovich M., Discrete and equal convergence, Studia Sci. Math. Hungar., 1975, 10(3–4), 463–472]. Our definition of ideal equal convergence encompasses two different kinds of ideal equal convergence introduced in [Das P., Dutta S., Pal S.K., On and *-equal convergence and an Egoroff-type theorem, Mat. Vesnik, 2014, 66(2), 165–177]_and [Filipów R., Szuca P., Three kinds of convergence and the associated I-Baire classes, J. Math. Anal. Appl., 2012, 391(1), 1–9]. We also solve a few problems posed in the paper by Das, Dutta and Pal.
Clinical contraindications to allergen immunotherapy: an EAACI position paper

Clinical indications for allergen immunotherapy (AIT) in respiratory and Hymenoptera venom allergy are well established; however, clinical contraindications to AIT are not always well documented. There are some discrepancies when classifying clinical contraindications for different forms of AIT as 'absolute' or 'relative'. EAACI Task Force on 'Contraindications to AIT' was created to evaluate and review current literature on clinical contraindications, and to update recommendations for both sublingual and subcutaneous AIT for respiratory and venom immunotherapy. An extensive review of the literature was performed on the use of AIT in asthma, autoimmune disorders, malignant neoplasias, cardiovascular diseases, acquired immunodeficiencies and other chronic diseases (including mental disorders), in patients treated with β-blockers, ACE inhibitors or monoamine oxidase inhibitors, in children under 5 years of age, during pregnancy and in patients with poor compliance. Each topic was addressed by the following three questions: (1) Are there any negative effects of AIT on this concomitant condition/disease? (2) Are more frequent or more severe AIT-related side-effects expected? and (3) Is AIT expected to be less efficacious? The evidence, for the evaluation of these clinical conditions as contraindications, was limited, and most of the conclusions were based on case reports. Based on an extended literature research, recommendations for each medical condition assessed are provided. The final decision on the administration of AIT should be based on individual evaluation of any medical condition and a risk/benefit assessment for each patient.
REVERSE GENETIC SYSTEM FOR SARS-COV-2

Certain embodiments of the invention include recombinant reverse genetic systems for SARS-COV-2 virus.
Performance Comparisons of Parallel Power Flow Solvers on GPU System

This paper transforms sequential power flow problem to a parallel problem and solves it on GPU. In particular, we implement parallel Gauss-Seidel solver, Newton-Raphson solver, and P-Q decoupled solver using CUDA (Compute Unified Device Architecture) on GPU. The aim is to investigate the performance of the three different parallel power flow solvers. We use four IEEE standard power systems and one actual running power system from Shang dong Province as the test cases when comparing the speedups that a GPU system can provide. The results show that Newton-Raphson solver has the best speedup when it is operated on GPU, Gauss-Seidel solver performs the worst, and P-Q decoupled solver is in the middle. The test results also indicate that when the size of the system is small, GPU does not seem to have advantages over CPU from computation time perspective. However, as the size of the system increases, the advantages of GPU becomes more clear. For instance, when the system has close to one thousand bus counts, the GPU can provide as high as over fifty-three times speedup.
Abstract 3122: The DNA-PK inhibitor NU7441 inhibits non-homologous end joining, enhances radio- and chemosensitivity and increases dependence on homologous recombination in hepatocellular carcinoma cell lines

Background DNA double-strand breaks (DSBs), the most cytotoxic lesions induced by ionizing radiation (IR) and anticancer drugs such as topoisomerase II poisons (e.g., doxorubicin), are repaired by non-homologous end joining (NHEJ) and homologous recombination (HR). DNA-dependent protein kinase (DNA-PK), which initiates NHEJ, is up-regulated in hepatocellular carcinoma (HCC) (GEO profiles), possibly contributing to anticancer therapy resistance. To assess DNA-PK as a potential therapeutic target for chemo- and radio-sensitisation in HCC we determined the effect of the DNA-PK inhibitor, NU7441, on DSB repair and cytotoxicity in HCC cells. Methods DNA-PK protein levels and activation by IR (Western blot), DSB levels (y-H2AX foci), HR (RAD51 foci), cell growth (DAPI fluorescence) and cytotoxicity (colony formation) following exposure to IR or doxorubicin was determined in a panel of 6 hepatoma cell lines (HepG2, Hep3B, Huh7, SNU-182, SNU475 and PLC/PRF/5). Results DNA-PK protein concentration and activity did not vary significantly across the panel (±24% and ±37%, respectively) but there were cell-specific sensitivities to IR and doxorubicin (e.g. HepG2 2-fold more resistant than Hep3B). NU7441 significantly sensitised all cells to both doxorubicin (average PF50 4.3±3.0) and IR (average PF50 3.9±1.1) in growth inhibition assays and significantly reduced survival (4.8 to 3.3-fold) in colony forming assays. Following exposure to IR, NU7441 significantly delayed yH2AX focus clearance in all cell lines (e.g. only 13% cleared at 4 hr compared to 50% in control), but increased RAD51 focus formation (3-fold). Conclusion While chemo- and radio-sensitivity in HCC cells was not dependent on DNA-PK expression or activity, NU7441 causes greater than 2-fold chemo- and radiosensitisation in all cells. This was accompanied by a substantial reduction in the rapid phase of DNA repair (NHEJ-dependent) and a shift to a greater reliance on the slower HR repair. DNA-PK inhibitors may have potential as chemo- and radio-sensitisors in hepatoma patients. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 3122. doi:1538-7445.AM2012-3122
Centrality evolution of the charged-particle pseudorapidity density over a broad pseudorapidity range in Pb–Pb collisions at sNN=2.76 TeV

The centrality dependence of the charged-particle pseudorapidity density measured with ALICE in Pb-Pb collisions at $\sqrt{s_{\rm NN}}$ over a broad pseudorapidity range is presented. This Letter extends the previous results reported by ALICE to more peripheral collisions. No strong change of the charged-particle pseudorapidity density distributions with centrality is observed, and when normalised to the number of participating nucleons in the collisions, the evolution over pseudorapidity with centrality is likewise small. The broad pseudorapidity range allows precise estimates of the total number of produced charged particles which we find to range from $162\pm22$ (syst.) to $17170\pm770$ (syst.) in 80-90% and 0-5 central collisions, respectively. The total charged-particle multiplicity is seen to approximately scale with the number of participating nucleons in the collision. This suggests that hard contributions to the charged-particle multiplicity are limited. The results are compared to models which describe $\mbox{d}N_{\mbox{ch}}/\mbox{d}\eta$ at mid-rapidity in the most central Pb-Pb collisions and it is found that these models do not capture all features of the distributions.
Selective pager and paging system

Group identification codes, names of parties to be sent, and telephone numbers of the pagers of the parties to be sent are stored in groups in memory 3 of a selective pager. At the time of transmission of a message, telephone numbers of a specified group and a message to be sent for the group are selected from the memory. The telephone numbers and the message are alternately sent to a DTMF signal generation section 8, which converts the telephone numbers and the message to DTMF signals. The DTMF signals are then converted into acoustic signals by means of a speaker 9 and are continually transmitted by way of a transmitter of a telephone set. As a result, a group call can be implemented without involving laborious operations, such as transmission of the telephone numbers and the message one by one.
Earth observation for maritime navigation

EONav presents an entirely new concept of combining space-based remote sensing observations which are offered by Copernicus with local maritime ship observations to aid maritime sail planning for fuel, emission and fatigue optimization. High fuel costs, consequences of delays in ship passages, reduction of SO2/CO2/NOx and similar emissions and other constraints are now putting more pressure on the maritime industry. Thus utilizing sea state, sea ice and AIS observations from space-based remote sensing, and particularly from Copernicus, allow the sea masters and planners to integrate more accurate and reliable observations to optimize their sail plan and thereby greatly increase profitability. This project is going to bring Copernicus remote sensing observations into sail planning tools with the objective of very significantly improve sail plan accuracy and reliability.
JACKING SYSTEM

The invention relates to a jacking system for jacking a structure, in particular for jacking offshore platforms or vessels out of the water, said jacking system comprising a leg having a longitudinal axis and comprising first engagement parts along said leg, and a guiding frame displaceable along said leg, said guiding frame comprising at least a first, second, third and fourth actuator, said actuators each having a first and second actuator part which in operation can displace with respect to one another along said leg, said first actuator part of said actuators coupled to said guiding frame, said second actuator parts of s aid actuators each coupled to first engagement parts for engaging and disengaging said first engagement parts of said leg for providing abutment in the longitudinal direction of said leg, said second actuator parts of said actuators displaceable along said leg past one another, and said actuators being arranged in pairs opposite one another with respect to a longitudinal plane of said leg. This jacking system provides a faster jacking of for instance vessels for offshore construction.
Re-Mapping the numerical brain.

Little is known on how the math system overcomes selective damage to parts of its brain bases. Indeed, brain adaptation has been observed in other domains, such as language: the loss of key language-related areas very often leads to brain reconfiguration for an ultimate successful behavior. Functional redundancies and remapping become visible in brain tumor patients for whom the slow growth of a tumor allows for functional reorganization. Re-MAPMATH aims the tracking of plastic brain changes behind math functions before and after surgery in brain tumor patients. For this, we will use neuroimaging techniques that allow for an optimal spatiotemporal resolution, entailing an advanced approach in the field of math cognition. The project main objectives are: (1) to precisely describe the brain bases for different math processes in the normal population, including functional activations and functional connectivity (2) to track how these default activations, functional and structural connectivity are modified by the growth of a tumor and (3) by the resection of the tumor, measuring three months after surgery. Finally (4), we aim the detection of commonalities across patients with the goal of describing redundancies and alternative pathways that allow a successful numerical behavior. In turn, uncovering these alternative neurofunctional systems can ultimately explain compensation in math disorders, as well as provide with useful information for the rehabilitation of essential math functions after surgery.
PEDESTAL WITH MULTI-ZONE HEATING

A method and apparatus for improved temperature control of a substrate is disclosed. In one embodiment, a pedestal is disclosed that includes a top plate, and a base plate coupled to the top plate, wherein the top plate comprises a multi-zone heater and the base plate comprises a plurality of grooves formed in a bottom surface thereof.
Web-based phenotyping for Tourette Syndrome: Reliability of common co-morbid diagnoses

Collecting phenotypic data necessary for genetic analyses of neuropsychiatric disorders is time consuming and costly. Development of web-based phenotype assessments would greatly improve the efficiency and cost-effectiveness of genetic research. However, evaluating the reliability of this approach compared to standard, in-depth clinical interviews is essential. The current study replicates and extends a preliminary report on the utility of a web-based screen for Tourette Syndrome (TS) and common comorbid diagnoses (obsessive compulsive disorder (OCD) and attention deficit/hyperactivity disorder (ADHD)). A subset of individuals who completed a web-based phenotyping assessment for a TS genetic study was invited to participate in semi-structured diagnostic clinical interviews. The data from these interviews were used to determine participants' diagnostic status for TS, OCD, and ADHD using best estimate procedures, which then served as the gold standard to compare diagnoses assigned using web-based screen data. The results show high rates of agreement for TS. Kappas for OCD and ADHD diagnoses were also high and together demonstrate the utility of this self-report data in comparison previous diagnoses from clinicians and dimensional assessment methods.
Protection and sustainable development of the Carpathians in a transnational framework

Historically, mountain regions located in remote border areas were often marginalised. They separate countries and peoples and face huge challenges regarding spatial development. However, mountain regions can also become powerful unifiers and a link between nations and peoples. As experiences, for example in the Alps, demonstrate, mountains have a considerable potential for development if the rich natural and cultural heritage is employed appropriately and if this heritage is preserved for the future. The Carpathians are located in one of the most dynamic regions in Europe with a huge potential for development. The central objective of the Carpathian project is the integration of European spatial development policies and management of the fragile mountain ecosystems of the Carpathians in a transnational context. The project will analyse and consolidate the information base, develop strategies and policy instruments. It will also implement and test pilot activities in cooperation with local and regional stakeholders. The project builds on the existing structure of the Carpathian Convention, providing a transnational framework for the application of EU policies throughout the Carpathian region. The project will make a comprehensive
 assessment of the needs, strengths and weaknesses of the project region. Moreover, the Carpathian project will analyse typical constraints of mountainous regions in the context of economic transition and European integration. It will deliver strategies and best practices for further development, building on the region's potential while safeguarding its natural and cultural heritage.
A GP prescription for exercise: Scotland to the Sahara

Andy Murray (a different Andy Murray!), who recently completed his GP training year with us in Hawick, is about to undertake the challenge of his life so far … running from the snow in Scotland to the sand dunes of the Moroccan Sahara and covering 2650 miles, the equivalent of 100 marathons, in 85 days with no days off. He starts in November and, if he is successful (and those who know him don't doubt that he will be), he will earn himself a place in the Guinness Book of Records .

Not exactly a slouch to date (he recently shattered the record for running the length of Hadrian's Wall by finishing the 84-mile stretch in 16 hours and 59 minutes, 3 hours faster than previous holder, and he has run marathons at …
SHAPED ARTICLE AND METHOD FOR PRODUCING A SHAPED ARTICLE

The invention relates to a shaped article, particularly for a pressure sensor, comprising a membrane and a support section supporting the membrane, at least parts of the membrane being produced from a ceramic material by additive manufacturing, particularly 3D screen printing, and the greatest possible distance between two points on the outer periphery of the membrane (12) being less than 20 mm.