SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Osteomir-Test – an in-vitro test for the diagnosis of osteoporosis and associated fracture risk

TAmiRNA aims to commercialize an in-vitro diagnostic test that is intended to predict fracture-risk in case of osteoporosis. The OsteomiR-Test meets an urgent clinical need by combining superior diagnostic performance with a simple test principle, thus, ensuring cost competiveness, good scalability and commercial success.
Osteoporosis is a chronic skeletal disease characterized by systemic loss of bone strength and consequently high incidence of bone fractures. Osteoporotic fractures constitute one of the most common and costly health problems in the European Union (EU): costs related directly to fractures were EUR 24.3 billion in 2004 and will rise to EUR 76.8 billion by 2050 due to increasing life expectancy. 
Effective fracture prevention can be achieved through exercise, diet and drug treatment, but depends on reliable early prognosis of fracture risk. Currently, bone mineral density and clinical factors are the basis for prognosis of fracture risk. However, the low specificity of these tests limits efficient fracture prevention and creates an urgent clinical need for novel and better tests.
The OsteomiR-Test measures a proprietary combination of circulating microRNAs from standard blood samples. The analyzed microRNAs provide a direct readout of bone metabolism, stress and biological age, and have been demonstrated to have a strong association with fracture-risk. It is a robust, easy-to-use test with good scalability. 
In order to commercialize the OsteomiR-Test, a detailed assessment of a market entry strategy is required. Therefore, TAmiRNA will i) develop health economic models to prioritize EU-countries for market launch, (ii) identify suitable manufacturing and distribution partners, (iii) define a strategy for IVD regulatory approval and, (iv) conduct a freedom-to-operate analysis. The results of this feasibility study will help to select target markets and define the cost structure of the test, and are therefore essential to successful commercialization.
Installation of application software through a network from a source computer system on to a target computer system

A technique for the remote installation of application software from a source computer system to one or more target computer systems (workstation) coupled to a Local Area Network (LAN). The present invention allows a LAN Administrator to install application software on a user's workstation automatically at any time without user's intervention. The state of (i.e. a snapshot of) the LAN Administrator's system before and after the installation of the application software is captured and an installation package is built. Installation on the user workstations is then scheduled. For installation, the installation package is transmitted to the user workstation where an install program carries out commands in the installation package for installing the application software.
On the gravity and geoid effects of glacial isostatic adjustment in Fennoscandia - a short note

Abstract Many geoscientists argue that there is a gravity low of 10-30 mGal in Fennoscandia as a remaining fingerprint of the last ice age and load, both vanished about 10 kyr ago. However, the extraction of the gravity signal related with Glacial Isostatic Adjustment (GIA) is complicated by the fact that the total gravity field is caused by many significant density distributions in the Earth. Here we recall a methodology originating with A. Bjerhammar 35 years ago, that emphasizes that the present land uplift phenomenon mainly occurs in the region thatwas covered by the ice cap, and it is highly correlated with the spectral window of degrees 10-22 of the global gravity field, whose lower limit fairly well corresponds to the wavelength that agrees with the size of the region. This implies that, although in principle the GIA is a global phenomenon, the geoid and gravity lows as well as the land upheaval in Fennoscandia are typically regional phenomena that cannot be seen in a global correlation study as it is blurred by many irrelevant gravity signals. It is suggested that a regional multi-regression analysis with a band-limited spectral gravity signal as the observable, a method tested already 2 decades ago, can absorb possible significant disturbing signals, e.g. from topographic and crustal depth variations, and thereby recover the GIA signal.
SYSTEM AND METHOD FOR PROVIDING DYNAMIC CLOCK AND VOLTAGE SCALING (DCVS) AWARE INTERPROCESSOR COMMUNICATION

Systems and methods that allow for Dynamic Clock and Voltage Scaling (DCVS) aware interprocessor communications among processors such as those used in or with a portable computing device ("PCD") are presented. During operation of the PCD at least one data packet is received at a first processing component. Additionally, the first processing component also receives workload information about a second processing component operating under dynamic clock and voltage scaling (DCVS). A determination is made, based at least in part on the received workload information, whether to send the at least one data packet from the first processing component to the second processing component or to a buffer, providing a cost effective ability to reduce power consumption and improved battery life in PCDs with multi-cores or multi-CPUs implementing DCVS algorithms or logic.
Subsurface evaluation of carbon capture and storage and unconventional risk

Subsurface Evaluation of CCS and Unconventional Risks (SECURe) will gather unbiased, impartial scientific evidence for risk mitigation and monitoring for environmental protection to underpin subsurface geoenergy development. The main outputs of SECURe will comprise recommendations for best practice for unconventional hydrocarbon production and geological CO2 storage. 
The project will develop monitoring and mitigation strategies for the full geoenergy project lifecycle; by assessing plausible hazards and monitoring associated environmental risks. This will be achieved through a program of experimental research and advanced technology development that will be demonstrated at commercial and research facilities to formulate best practice. We will meet stakeholder needs; from the design of monitoring and mitigation strategies relevant to operators and regulators, to developing communication strategies to provide a greater level of understanding of the potential impacts.
The SECURe partnership comprises major research and commercial organisations from countries that host shale gas and CCS industries at different stages of operation (from permitted to closed). We will form a durable international partnership with non-European groups; providing international access to study sites, creating links between projects and increasing our collective capability through exchange of scientific staff. 
SECURe will provide a legacy of:
1. A network of experimental and industrial field sites as a proving ground for cutting edge technologies and to enable knowledge transfer between sectors;
2. A platform for international cooperation; 
3. A scientifically sound, unbiased and independent best practice for baselining, monitoring, mitigation and remediation – within a risk-assessment framework;
4. Models and best practice guidelines for engaging different stakeholders including citizens through participatory monitoring;
5. A formal continuous training programme for researchers and students.
Innovative Development of European Areas by Fostering Transnational Knowledge Development

Certain innovation processes cannot be realized without people and their ideas. The project focuses on development of strategies that will safeguard human capital for these processes and establishes transnational cooperation for coping with this challenge, especially in the sector of engineering technology and science.

Project partnership decided to look for a holistic European solutions by overcoming predominantly regionally focused methods when developing innovation strategies.
The different regional approaches will be therefore improved, good practice examples defined and new opportunities for its further development determined. The project partnership consists of experienced and competent partners from the participating regions representing development agencies, business support and innovation agencies, as well as municipalities and universities from all 8 CE countries. It initiates the formation of co-operative structures between universities, educational institutions and regional decision makers, which constitute stable networks based on structural funding until the end of the project.
Safe and green sensor technologies for self-explaining and forgiving road interactive applications

SAFE STRIP aims to introduce a disruptive technology that will achieve to embed C-ITS applications in existing road infrastructure, including novel I2V and V2I, as well as VMS/VSL functions into low-cost, integrated strips markers on the road; to make roads self-explanatory and forgiving for all road users (trucks, cars and vulnerable road users, such as PTWs riders) and all vehicle generations (non-equipped, C-ITS equipped, autonomous), with reduced maintenance cost, full recyclability and added value services, as well as supporting real-time predictive road maintenance functions. The vast potential of SAFE STRIP will be demonstrated through applications for: 1) Cooperative safety functions for enhanced ADAS/ARAS equipped and non-equipped vehicles, 2) Road wear level and predictive road maintenance, 3) Road work zones and railway crossings warnings, 4) Merging/intersection support, 5) Personalised VMS’/VDS’ and Traffic Centre Information, 6) Dynamic trajectory estimation and interface to automated vehicles, whereas it will open a new channel to a vast array of 7) Supportive added value services (such as Virtual Toll Collection and Parking booking and charging). It will be evaluated in a test bed in Spain and in France and 2 closed test tracks in Italy and in real life conditions in Greek and Italian highways, with 4 car and 3 PTW demonstrators. This very challenging task is undertaken by a muldisciplinary and complementary Consortium of 18 Partners from 6 countries, with a good representation of all stakeholders: 1 vehicle OEM (CRF), 1 PTW OEM (Piaggio), 2 system integrators and infrastructure installers (3M & CEA), 2 Tier 1 suppliers (CONTI & VALEO), 1 SME (RELAB), 8 R&D Institutes (CERTH, UNITN, UPAT, FhG/IAO, CNR, CIDAUT, CTI and ICCS) and 2 end users (ATTD and Α22) as beneficiaries, under the umbrella of ERTICO; thus providing further access to all key stakeholders in the area.
Transportation: An Electronic Survey of Persons who Are Blind or Have Low Vision

Introduction Individuals who are blind or have low vision (hereafter, visually impaired) encounter transportation barriers that impede their full participation in life activities, including transportation. This survey is the first national survey to focus specifically on the transportation issues of persons with visual disabilities. Methods A transportation survey was developed and disseminated electronically to people who are visually impaired. The first administration, in the fall and winter of 2013, went to persons in a volunteer registry. For the second administration, in early 2014, participants were recruited through electronic postings and e-mails with assistance from consumer groups and professional organizations. The combined useable sample of 492 included individuals with legal blindness ( n = 265), total blindness ( n = 188), and low vision ( n = 39). Results Participants were likely to have received orientation and mobility (O&amp;M) training, and were confident in their O&amp;M skills. They were also likely to have access to public transportation, to use public transportation to get to work, and to be generally satisfied with how they got to work. Transportation issues were less likely to impact participation in employment than several other life activities. Although most participants had received services from vocational rehabilitation agencies, few said those agencies assisted them in finding transportation to work. Discussion Although transportation issues affect the lives of persons with visual disabilities, the extent of their impact on employment remains unclear. Survey respondents appear to be using their O&amp;M skills, to be fairly comfortable traveling, and to be generally satisfied with how they travel to work, thus confirming the importance of receiving quality O&amp;M instruction. Implications for practitioners Service providers should consider evaluating the effect that transportation issues are having on the lifestyles of consumers. Individuals with visual impairments should be encouraged to take advantage of quality O&amp;M instruction so that they can confidently access public transportation systems. More active rehabilitation practitioner participation in assisting consumers locate employment-related transportation is suggested, and evaluating the effect of that assistance would prove helpful.
Effect of Sources and Storage Conditions on Quality of Sorghum Seeds

A study was conducted in three agro-ecological zones of Tanzania to investigate sources, status, quality and storage conditions of sorghum ( Sorghum bicolor L.) seeds. Sorghum seed samples were collected from Kwimba (Lake zone), Chamwino (Central zone) and Kilosa (Eastern zone) districts. In surveyed districts 83.3 % of farmers were using farmer saved seeds while 16.7 % were using improved sorghum seeds. In surveyed areas, 85 % of seed samples were obtained from small scale farmers as farmer saved seeds, 1.7% from seed stockists and 13.3% from agriculture research institutions. Seeds were found stored in the households (86.7%) and in go-down in case of seeds stockists (13.3%). The laboratory purity analysis test results indicated that Kwimba had pure seeds of 94.4%, Chamwino 96.5% and Kilosa 99.0%. Inert matters; Kwimba 5.3%, Chamwino 1.8% and Kilosa 1.0%. The non-sorghum seeds observed were Kwimba 0.2%, Chamwino 1.8% and Kilosa 0%. The results were significantly different at P<0.001 from one agro-ecological zones to another. The germination test of sorghum seeds varied highly significantly (P<0.001) from Kwimba 74%, Chamwino 88% and Kilosa 85%. Seed-borne fungal species found in the samples from the study areas were Fusarium moniliforme, Bipolaris sorghicola, Curvularia lunata, Colletotrichum graminicola and Phoma sorghina . Samples collected from Eastern zone had the highest infection by fungi. Other pathogens Aspergillus flavus, A. niger, Penicillium spp., Claviceps spp. and Rhizopus spp . were found infecting seeds. Central agro-ecological zone is proposed to be better for sorghum seeds production for healthier seeds due to non-fungal infection observed in this study. Key words : agro-ecological zones, seed, moisture content, purity, germination, seed-borne pathogens
Potential Landscape and Flux of p53-Mdm2 Oscillator Mediated by Mdm2 Degradation Rate

The dynamics of the tumor suppressor p53 can play a crucial role in deciding cell fate after DNA damage. In this paper, we explore the dynamics and stability of p53 mediated by Mdm2 degradation rate in p53-Mdm2 oscillator through bifurcation, the potential landscape and flux. Based on the investigation of the bifurcation, we find that p53 can exhibit rich dynamics including monostability, bistability of two stable steady states and oscillation behaviors as well as bistability between a stable steady state and an oscillatory state. The stability of these states are further validated by the potential landscape. In addition, oscillatory behaviors of p53 are explored by means of the negative gradient of the potential landscape and the probability flux. It is shown that the negative gradient of the potential landscape can attract the system towards the oscillatory path and the flux can drive oscillation along the path. Moreover, the quicker the flux runs, the smaller the period is. Besides, stability and sensitivity of the system are explored by the barrier height and the entropy production rate in a single cell level, and we further compare the potential landscapes at single and population cell levels. Our results may be useful for understanding the regulation of p53 signaling pathways in response to DNA damage.
Modelling long-term seismic noise in various environments

SUMMARY The strongest seismic noise, called secondary microseisms, is generated by ocean wave interactions and we model this noise using the theory of Longuet-Higgins generalized to random ocean gravity waves. Noise sources are computed with an ocean wave model that takes into account coastal reflections. Variations of the source locations are consistent with seasonal variations of seismic noise spectra. Noise spectra are modelled over many years for stations representative of various environments such as continent, island and polar area to constrain, for each environment, the parameters involved in the modelling. For each station, we quantify the trade-off between ocean wave coastal reflection and seismic wave attenuation that both affect the amplitude of the seismic spectrum. We show their adjustment and the need, at some stations, for an extra parameter representing the three-dimensional (3-D) seismic wave propagation effects. The long-term analysis demonstrates the stability of the fitted parameters which can be used in future noise studies. The modelling enables to reproduce the frequency content and amplitude of the different noise peaks of seismic spectra. The strongest peaks are generated by deep ocean sources whereas coastal reflections generate numerous smaller sources that contribute to the background noise level. Coastal reflection effects can be neglected only for the Pacific island station PPT. The modelling also reproduces the peculiar noise spectrum variation in Antarctica (station DRV) which is related to the presence of sea ice around the stations.
Support for maintaining the business of INFUZJI ADAM keels

The aim of the project is to help maintain the company’s financial liquidity. The company operates in the tourism industry in Duszniki Zdrój in the district of Kłodzkie. Following the outbreak of the pandemic, the company suffered the following negative effects: — the decline in the number of customers or, in fact, their lack – a significant decrease in turnover – sending employees to parking – lack of liquidity – the costs incurred on taxes, electricity, water, negative economic consequences due to COVID-19 are very large for the company. Business ban from 16.03.2020 to 04.05.2020 All organised groups have been revoked. Reservations of the Easter world have been cancelled. The losses are very high. The aid received will be used for: — taxes – ZUS – Staff costs – Facility maintenance costs: electricity, water, garbage, etc. – maintenance of the existing standard of the facility and its further development
Correlations of Radiographic Findings in Patients with Low Back Pain.

BACKGROUND: Low back pain can cause severe debilitating pain that may lead to loss of productivity. The pain is usually non-specific and imaging request protocols varies. However, physicians may order lumbo-sacral x-ray in the initial radiologic assessment of the patient. This study aims to determine the frequency of occurrence of radiographic findings in patients reporting low back pain including the presence of osteophytes, spondylolisthesis and degenerative disc diseases and determine the relationship with patients' features including age, sex, marital status, level of education, body mass index and other radiographic findings. METHOD: Patients who presented at our department for radiographic assessment of the lumbo-sacral spine were voluntarily recruited. Their radiographs were reviewed and questionnaire administered. Height and weight were measured. The radiographic findings were documented and data analysis using Chi square with significant level set at p < 0.05. RESULT: Lumbo-sacral x-rays of 337 patients were reviewed with more females than males, ratio 1:1.4. Osteophytes were demonstrable in 73.6%; spondylolisthesis, 13.4%; and disc degeneration, 28.2%. Disc degeneration correlated with age, educational status, osteophytosis, osteopenia and spondylolisthesis. Osteophytosis correlated with age, BMI and educational level. While spondylolisthesis correlated with educational level and sex. CONCLUSION: Osteophytosis was the commonest finding in patients presenting with LBP. Disc degeneration shows a strong association with osteophytosis and spondylolisthesis and it is reported to herald these changes. Radiography still shows some correlations between the findings in LBP and patients' characteristics.
Chlorhexidine digluconate as corrosion inhibitor for carbon steel dissolution in emulsified diesel fuel

Abstract Nitrogen oxide (NO x ) and particulate matter (PM) emissions from diesel engines are reduced by mixing water in the diesel fuel in the form of water-in-diesel emulsion. The results of experiment showed that blend of span 80 and tween 80 at HLB 6 was found to be the most suitable emulsifier for water/diesel emulsion. The effect of chlorhexidine digluconate on the corrosion of carbon steel electrode in aerated stagnant water/diesel emulsion solution has been studied using potentiodynamic polarization and electrochemical impedance spectroscopy (EIS) techniques. The inhibition efficiency was found to increase with increasing inhibitor concentration. The inhibition is attributed to adsorption of the inhibitor on the carbon steel surface. The adsorption behavior of chlorhexidine digluconate on the carbon steel surface follows Temkin-type isotherm. The standard free energies of adsorption are lower than 40 kJ mol −1 confirming the physical adsorption of chlorhexidine digluconate on the electrode surface. Chlorhexidine digluconate has a significant inhibiting effect on the growth of micro-organisms in the liquid fuel and protection efficiencies up to 99.9% were measured.
Revolutionizing insect control

EFSA recently prohibited 75% of insecticides to account for their toxicity and ecotoxicity. Moreover, the spread of insecticide resistance and invasion of Europe by new tropical vectors and pests require the development of alternative biological techniques.
Recently, we hypothesized that shifting the vision of the sterile male from a sexual competitor only to a specific transporter of active biocides to the targeted female might boost the impact of the sterile insect technique (SIT). Here we want to demonstrate this concept using three biocides: Pyriproxifen, Bacillus thuringiensis and a Densovirus against the Tiger mosquito (Aedes albopictus). Pyriproxifen will also be tested against tsetse and fruit flies.
We will test the technology both in the laboratory and at an operational scale and model the relative impacts of SIT and boosted-SIT on the dynamics of the targeted population.  Moreover, we will compare the evolutionary response of the target population to these different control pressures (multiple lethal mutations, multiple lethal mutations + biocides), for three different biocides and three demographic strategies.  This will generate breakthrough knowledge on the transmission of biocides and pathogens in insects and the sustainability of genetic control, provide a new control technique for mosquitoes, and improve the cost-effectiveness of SIT in tsetse and fruit flies.
We will have to address technical issues associated to mass rearing, sterilization, sex separation and aerial release of mosquitoes as well as regulatory issues required for releasing sterile males coated with bioicides.