SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Lipid droplet hypertrophy : the link between adipocyte dysfunction and cardiometabolic diseases

The goal of SPHERES is to understand the dynamics and consequences of adipocyte hypertrophy (enlargement) through investigation of its large lipid droplet (LD). The adipocyte LD is a unique organelle specialized in storing energy in triglycerides (TGs). Its surface is composed of a phospholipid monolayer and specific LD-associated proteins (such as perilipins, CIDEs and lipases), which jointly regulate LD stability and TG turnover. Adipocyte hypertrophy due to an increase in LD size may, irrespective of body fat mass, cause a wide range of pathological conditions, notably cardiometabolic diseases. SPHERES PIs (Langin, Rydén, Antonny) postulate that disturbances in the interactions between LD proteins and LD lipid composition lead to adipocyte hypertrophy and its deleterious consequences. We have identified three fundamental unanswered questions: what determines the unique structure and dynamics of large LD; why does increased LD size alter the functional phenotype of the adipocyte; which factors cause inter-individual variations in LD size. To address these questions, SPHERES gathers expertise in clinical and cellular studies on human adipocytes, in/ex vivo investigations in mouse models, and biophysical analyses of LDs. At the core of this application is the development of beyond-state-of-the-art models and methods (spheroid cultures, native large LD preparation and reconstitution, proximity labelling of LD proteins, gene editing in cell and mouse models, and advanced LD imaging), only achievable through joint integrated effort of the PIs and co-workers. Spanning from molecular, cellular to the whole-body level, SPHERES will link new knowledge on the formation and maintenance of large adipocyte LDs to the deleterious impact of adipocyte hypertrophy. Altogether, SPHERES has a strong potential to discover novel pathogenic mechanisms, leading to a better understanding of highly prevalent diseases and identification of therapeutic strategies targeting adipocytes.
Simulation based optimisation model for the lean assessment in SME: a case study

Due to their space limitation and small production scale, small and medium enterprises (SME) are vulnerable to rapid changes. Lean principles are considered as effective improvement approach to eliminate system's waste and inefficiencies. Although much of the academic materials have addressed the lean practices into large, global companies, they can still be adjusted to SMEs. Risks are usually associated with lean implementation process due to the drastic required changes in business policies and operations. Simulation can be successfully used to predict the impact of the proposed changes ahead of the implementation which helps to mitigate risks. Integrating simulation with optimization techniques provides optimum settings of the lean factors prior to the go live stage. In this study, simulation based optimization model was developed to optimize a set of parameters of lean SME against three performance measures -- cycle time, WIP (work in process) and workforce utilization. Results showed constructive insights.
IMAGING LAYERS, STRUCTURES INCLUDING IMAGING LAYERS, METHODS OF MAKING IMAGING LAYERS, AND IMAGING SYSTEMS

Imaging layers, image recording media, and methods of preparation of each, are disclosed.
Eco-Innovative maceration system based on lfhp ultrasound technology for winemaking

AGROVIN will put in the market ULTRAWINE, a low frequency high power (LFHP) ultrasound equipment designed for optimizing the extraction of phenolic compounds from grape skins during the first stages of winemaking. Our proposed innovation allows completing the grape maceration process in 6 hours while current systems take approximately 4 days, with 30 times less energy and the ability to process triple amount of grape. ULTRAWINE renders a high quality must with an intense colour and aroma, setting the adequate basis for an excellent wine.

The general objective of ULTRAWINE is to put into the market a high performance equipment to assist the extraction of phenolic compounds in the grape peels based on low frequency high power (LFHP) ultrasound technology, in a period of 24 months, with the aim of selling an accumulated amount of 130 units by 2021.
Aider les entreprises enregistrées en vertu de la loi sur le tourisme en tant qu’organisateur de voyages ou agence de voyages à surmonter les conséquences économiques de la pandémie de COVID-19

Aider les entreprises enregistrées en vertu de la loi sur le tourisme en tant qu’organisateur de voyages ou agence de voyages à surmonter les conséquences économiques de la pandémie de COVID-19
Cutting Edge: Critical Role for C5aRs in the Development of Septic Lymphopenia in Mice

In the early stages of sepsis, lymphocytes undergo apoptosis, resulting in lymphopenia and immunosuppression. The trigger for septic lymphopenia is unknown. Using the polymicrobial model of murine sepsis, we investigated the role of C5a receptors in septic lymphopenia. In wild-type mice, cecal ligation and puncture resulted in splenocyte apoptosis and significant lymphopenia after 3 d, which was not observed in C5aR1(-/-) or C5aR2(-/-) mice. Our data show that mouse neutrophils exposed to recombinant mouse C5a cause release of histones in a dose-dependent and time-dependent manner. Histone levels in spleen were significantly elevated following cecal ligation and puncture but were reduced by the absence of C5aR1. Histones induced significant lymphocyte apoptosis in vitro. Ab-mediated neutralization of histones prevented the development of lymphopenia in sepsis. Together, these results describe a new pathway of septic lymphopenia involving complement and extracellular histones. Targeting of this pathway may have therapeutic benefit for patients with sepsis or other serious illness.
Preliminary study on navigation development and comprehensive improvement of North Cannel

Based on a deep investigation on the history and present status of Jinghang Grand Canal,the feasibility of the navigation and comprehensive improvement of the river reach of the North Canal between Beiguan Sluice in Tongzhou Distrct of Beijing and Qujiadian Barrage Project in Beichen District of Tianjin is studied;in which the main technical difficulties of the navigation of the canal is analyzed,and then the technical schemes for the navigation with two ship-locks and four ship-locks are compared in accordance with the waterway classifications of both V and VI.Furthermore,an extensive study is made from the aspects such as the comprehensive utilization of water resources,flood control project,waterway regulation,sluice and bridge reconstruction,layout of wharf and pier,construction of landscape,water quality restoration,etc.It is recommended that a comprehensive improvement must be made on the navigation development of the canal,i.e.besides the consideration on the technical requirement of the navigation,the water transport culture of the canal with a history of nearly a thousand years must be inherited and continued,while the eco-environment suitable for living must be constructed as well.
Improved trustworthiness and weather-independence of conditional automated vehicles in mixed traffic scenarios

Automated driving can be implemented with relatively simple controllers if the current location of the ego vehicle and the current and future locations of other road users are known without uncertainty. However, this is not going to happen in the initial stages of the introduction of automated driving systems into the market. As a consequence, system and human driver uncertainty pose a significant challenge in the development of trustable and fault-tolerant automated driving controllers, especially for conditional automation (SAE level 3) in mixed traffic scenarios. The TrustVehicle consortium brings together participants from the whole vehicle value chain to enhance safety and user-friendliness of level 3 automated driving systems. The main objectives are: (i) the systematic identification of critical road scenarios based on in-depth analysis of possible traffic situations and human behaviour; (ii) the setup of new tools for the cost- and time-effective assessment of driver-in/off-the-loop situations; (iii) design of controllers and sensor fusion systems capable of dealing with complex, uncertain and variable road scenarios to enhance road safety; (iv) the implementation of intuitive human-machine interfaces for the safe management of the transition phases taking into account user acceptance and gender-specific aspects; and (iv) the establishment of an adaptive and agile vehicle validation based on self-diagnostics and data logging to steadily extend the list of relevant scenarios and test cases. The outputs of the TrustVehicle project will be extensively assessed in real-world operating conditions on four demonstrators representing four vehicle classes. End users of the technology will systematically and thoroughly express their requirements, expectations, and concerns during the consortium activity. Special focus will be put on the demonstration of the fault-tolerant and fail-operational system behaviour at any time and for different kinds of weather conditions.
Smart atmospheres of social and financial innovation for innovative clustering of creative industries in MED area

The cultural and creative (CC) sectors are some of Europe’s most dynamic sectors, with a 4.2% of total EU GDP generated. These sectors, often clusters suffer the lack of conjunctions between their CC components, making the cultural core still unable to fully express its potential in terms of fertilization of creative industries. In this conditions these sectors remain undervalued and unrecognised, especially in terms of their ability to access start-up capital and financing. One of the main challenges in these clusters is improving the connections between the cultural core engines and creativity in order to make the best of the synergies between the wealth of heritage traditions, values and symbols and the business environment that can add to them economic value and fully exploit their economic potential. SMATH’s main goal is to improve the quality and quantity of connections between the publicly oriented domain of culture and the business oriented domain of creativity via innovative forms of clustering “Smart Atmospheres”. SMATH intends to generate and strengthen “Smart Atmospheres” able to support the start-up and the development of SMEs in the CC sector facilitating the access to “culture factories” and value enhancing services (private and public finance) and the development of innovative clustering on CCIs level and the setting-up of joint cooperation at PPPs among investors and public actors able to exploit their potential to support the growth in the MED Area.
GAMMA-400 Space Gamma-telescope Mathematical Model with Engineering Elements Included

Mathematical model creation is a necessary stage in scientific apparatus development. The mathematical model of gamma-ray telescope GAMMA-400 is used to emulate transport of various elementary particles through the apparatus. The new iteration of the model is based on precise technical drawings and includes all the elements of the real gamma-telescope. It is created in Geant4 environment. This model allows calculation of energy deposition not only in detectors, but in any part of the apparatus, including construction elements. Moreover, it supports creation of virtual sensitive volumes, allowing determination of the number and properties of particles passing through an arbitrary part of the construction. Software for automated creation of Geant4 model based on technical drawings in STEP 3D Model format was developed. This software is capable of making models of other apparatus based particularly on scintillation and strip detectors.
Advances in inductive position sensor technology

Purpose The purpose of this paper is to outline the basic principles of inductive position sensors. Design/methodology/approach The paper explains one company's advances in inductive position technology in detail, together with some of the applications for which they are now suitable. Findings It is shown that concentrating on high volume applications in market sectors such as automotive, user interfaces, and utility metering, where the low cost of these sensors and their moderate accuracy (typically&lt;1 percent of full scale) offers an attractive price/performance ratio. Originality/value An original and useful contribution direct from an international technology consulting, product development, and intellectual property [IP] licensing organisation with a reputation for successfully commercialising emerging science and technology. Which, for more than a decade, has made innovations in inductive position sensors and developed application‐specific sensor systems.
Application of Geo-Spatial Techniques for Precise Demarcation of Village/Panchayat Boundaries

Abstract. In order to achieve the overall progress of the country with active and effective participation of all sections of society, the 12th Five Year Plan (FYP) would bring Panchayats centre-stage and achieve the inclusive growth agenda through inclusive governance. The concept of 'democratic decentralization' in the form of a three-tier administration was introduced in the name of "Panchayat Raj". Horizontally, it is a network of village Panchayats. Vertically, it is an organic growth of Panchayats rising up to national level. The Ministry of Panchayati Raj has three broad agenda: Empowerment, Enablement and Accountability. Space based Information Support for Decentralized Planning (SIS-DP) is one of the initiatives taken by Govt. of India with ISRO/DOS for generation and dissemination of spatial information for planning at the grass root level. The boundary layer for villages across different states/district/block is available with line departments. Most of these data exist at a much generalized scale. These boundaries do not overlay exactly with that of ground realities and may not be suitable for accurate analysis in terms of area, shape, position, etc. To deal with this problem, a strategy is adopted, which makes use of High Resolution Satellite Imagery (HRSI) from Indian Remote sensing satellites and cadastral maps at 1:4000 scale integrated with GIS techniques to enhance the accuracy of geo-spatial depiction of Village/Panchayat boundaries. Cadastral maps are used to depict the boundaries of land parcels and other features at the village level. These maps are registered to ortho products of HRSI using Ground Control Points. The cadastral maps are precisely overlaid on ortho-rectified HRSI and each parcel vertex is tagged with the real-world geographical coordinates. Village boundaries are extracted from the geo-referenced village cadastral maps. These boundaries are fine-tuned by considering under lap and overlap of neighboring villages and a mosaic is generated at the subdistrict and district level. Each village is coded with a unique number based on Ministry of Panchayati Raj and Census department codes. Villages are mapped to their respective Panchayat(s) directory and are dissolved in GIS environment based on code/nomenclature to obtain the final Gram Panchayat Layer. The present study attempts to showcase the methodology for deriving precise Village/Panchayat Boundaries using geo-spatial techniques. The final output will immensely help the Ministry of Panchayati Raj and Rural Development for implementing the developmental programs in tune with 73th and 74th constitutional amendments.
European global transition network on eco-innovation, green economy and sustainable development

In the last two decades the world has experienced several crises. In light of these trends and to more effectively move towards sustainable development, several organisations and international actors have developed the concept of green economy as action-oriented approaches. Priority interventions are aimed at triggering technology adoption, and stimulate behavioural change. In fact, eco-innovation can be considered an enabler for a green economy to the same extent that the green economy can be understood as an enabler of sustainable development.
Green.eu is designed to address these challenges, ranging the conceptualization of eco-innovation and the green economy, to the harmonization of the approaches needed to coherently assess performance, identify gaps (successes and failures) for the effective adoption of technologies that can create win-win results. In particular, the project is designed so as to improve (1) harmonization of definitions, (2) collection of relevant information on the performance of past and current efforts, and (3) coordination among stakeholders. Green.eu sees the main challenges in an improved understanding (and scientific assessment) of the concepts of green economy and eco-innovation, on the adaptation of policy agendas, the documentation of best practices and guidelines for knowledge transfer and transferability.
The inter- and transdisciplinary green.eu network (including knowledge brokers, programme owners and global industry networks) is research based and aims to accelerate the transition towards a green economy significantly, with a European focus on co-development of knowledge. It aims to exploit win-win-opportunities and to improve the take up of R&D results. It includes the following work packages: Networking and co-ordination; Harmonization of concepts of green economy and eco-innovation; Eco-innovation policy agendas; Best practices, knowledge transfer, transferability; Integration and operationalization of lessons learned.
Histologic Recurrence of Henoch-Schonlein Purpura Nephropathy After Renal Transplantation on Routine Allograft Biopsy

Henoch-Schonlein Purpura nephropathy (HSPN) recurrence in renal transplant recipients (RTRs) has been reported in 35% of patients, leading in 11% of these patients to graft loss at 5 years. However, its true incidence is unknown. The aim of this study was to investigate this recurrence incidence using routine allograft biopsies (RBs).All RTRs with biopsy-proven HSP initial nephropathy were included (13 RTRs and 18 renal transplantations). At transplantation, the median age was 34 years, and 85% of RTRs were men. Overall, we analyzed 66 RBs that were routinely performed at 3 and 12 months after RT and when clinically indicated. Histologic recurrence was defined as the presence of IgA deposits within the mesangium and along the glomerular capillary walls.After a median follow-up of 83 months (range, 13-232 months; interquartile range, 26-235 months), histologic recurrence was detected in 69% of patients and in 61% of grafts after a mean period of 24 months (range, 1-156 months). Clinical or biological signs were absent in all but one. Patient survival was 92.8%. Graft loss occurred in five cases, never were related to recurrence. At the last follow-up, the mean glomerular filtration rate was 48±14.2 mL/min/1.73 m(2); in patients with and without recurrence, the mean rates were 52.1±17.5 and 42.4±5.3 mL/min/1.73 m(2), respectively (P=0.27).Histologic recurrence of HSPN after RT is frequently observed on routine RBs but is not associated with clinical consequences. The short-term prognosis of recurrence is good, but its long-term prognosis remains to be determined.
Diaphora: philosophical problems, resilience and persistent disagreement

DIAPHORA serves as a European research and training platform for collaborative research on the nature of philosophical problems, their resilience and the sources of persistent divergence of expert opinion about them, and their relation to conflicts in the practical sphere. More specifically, DIAPHORA’s 3 principal research objectives are (A) to diagnose what makes philosophical problems so resilient and to clarify to what extent the sustained lack of convergence in philosophy can successfully be explained by the hardness of its problems; (B) to explain why the tendency has not been towards a general agnosticism about candidate solutions, but rather towards divergence, and to identify features of philosophical method that allow for such persistent peer disagreement; and (C) to explore whether the dynamics of philosophical debate, despite the subject’s highly theoretical nature, bears important and instructive resemblances to the dynamics of debates about more practical matters and their political and socio-economical antecedents – and hence whether philosophical problems and their attempted resolution can illuminate, and be illuminated by, the procedural and methodological difficulties besetting strategies for the adjudication of public affairs, thereby determining what philosophical thought might contribute to society at large. DIAPHORA joins 7 leading European research centres in philosophy, and 5 partner organisations, 3 of which from the non-academic sector, in the fields of international conflict management, mediation and policy-making, as well as the analysis of social conflict and cultural diversity. It undertakes to provide 14 Early Stage Researchers with the knowledge and skills necessary to meet the demands of top-level research within its remit, as well as professional complementary skills training in both the academic and non-academic sectors, with the goal of widening their potential societal contributions and improving their individual career prospects.
Commercial feasibility of targeting the histone methyltransferase setd8 in cancer: new chemical entities and biomarkers.

Within our ERC CoG grant, RSHEALTH, our group has contributed to the to the preclinical development of chemical inhibitors of the ATR kinase as anticancer agents, that are now in clinical trials by several companies. During the course of our investigations, we also made important advances in developing inhibitors of SETD8, another interesting cancer-related target. SETD8 is a histone methyltransferase known to play important roles in DNA replication and repair. Evidence indicating that targeting SETD8 could be interesting for cancer therapy has been building up in recent years. For instance, SETD8 is overexpressed in a wide range of cancers, and recent works identified SETD8 as a specific vulnerability in High-Risk Neuroblastoma or MYC-driven Medulloblastomas. Unfortunately, all available SETD8 inhibitors have low potency and poor pharmacological properties, and none has progressed to the clinic. We here propose to capitalize in our strengths in academic drug development, and our experience in transferring our inhibitors to the industry, in order to facilitate the clinical development SETD8 inhibitors. Our proposal includes objectives that will help us improve the quality of our inhibitors, valorise them in preclinical cancer models and develop companion biomarkers that would be used for patient stratification. All of this would be integrated within a business plan that should facilitate a coherent development of this line of work oriented towards the clinical development of SETD8 inhibitors for the benefit of cancer patients.
UNTERNEHMEN I.A.C.E. S.R.L.

DIE VON I.A.C.E. S.R.L. GEPLANTE MASSNAHME SIEHT DIE STÄRKUNG DES AUSHUBSEKTORS UND EINE ERHÖHUNG DER BETRIEBLICHEN FLEXIBILITÄT (IN BEZUG AUF NUMBERITÄT UND ARTEN VON AUSFÜHRBAREN VERFAHREN) VOR, DIE DURCH DEN ERWERB VON AUSRÜSTUNGEN IN KLEINEN, MITTLEREN UND GROSSEN AUFTRÄGEN WETTBEWERBSFÄHIGER WERDEN WERDEN: — NO.1 BOSH ABBRUCHHAMMER – N.1 DREHHAMMER 40MM – Nr. 3 SDS DÜBEL – Nr. 3 WINKELSCHLEIFER – N.1 BICCH BETONMISCHER. EINPHASIG – N.1 DIESELGENERATOR – N.1 SCHLAUCH 4T GX160 + CUTTER – N.1 HYDROVORA PUMPE – N.1 ELEKTROKOMPRESSOR – N.1 KETTENKARRE – Nr. 2 KETTENSÄGE 22,2CC 25CM – NO.1 KETTENSÄGE – Nr. 2 BAGGER – N.1 RUCKSACKBÜRSTE – NO.1 AMMANN RÜTTELPLATTE – NO.2 AMMANN STÖSSEL – Nr. 1 MINIBAGGER MIT HYDRAULIKSYSTEM KIT UND SATZ VON 3 EIMERN – Nr. 1 LKW MIT KIPPKIPPER – VERSCHIEDENE ARBEITSGERÄTE (GIRATUBES, SCHNEIDSCHEIBEN UND SCHLEIFSCHEIBEN, SCHRAUBENDREHER, RATSCHENSCHLÜSSEL, DOSEN, LAMPEG