SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Cell-Type specific mechanisms regulating rhythms in leukocyte homing

Leukocytes are the key components of the immune system that fight infections and provide tissue repair, yet their migration patterns throughout the body over the course of a day are completely unknown. Circadian, ~24 hour rhythms are emerging as important novel regulators of immune cell migration and function, which impacts inflammatory diseases such as myocardial infarction and sepsis. Altering leukocyte tissue infiltration and activation at the proper times provides an option for therapy that would maximize the clinical impact of drugs and vaccinations and minimize side effects. 
We aim to create a four-dimensional map of leukocyte migration to organs in time and space and investigate with epigenetics techniques the molecular mechanisms that regulate cell-type specific rhythms. We will functionally define the daily oscillating molecular signature(s) of leukocytes and endothelial cells with novel proteomics approaches and thus identify a circadian traffic code that dictates the rhythmic migration of leukocyte subsets to specific organs under steady-state and inflammatory conditions with pharmacological and genetic tools. We will assess the impact of lineage-specific arrhythmicities on immune homeostasis and leukocyte trafficking using an innovative combination of novel genetic tools. Based on these data we will create a model predicting circadian leukocyte migration to tissues. 
The project combines the disciplines of immunology and chronobiology by obtaining unprecedented information in time and space of circadian leukocyte trafficking and investigating how immune-cell specific oscillations are generated at the molecular level, which is of broad impact for both fields. Our extensive experience in the rhythmic control of the immune system makes us well poised to characterize the molecular components that orchestrate circadian leukocyte distribution across the body.
A framework for pairing circular economy and iot: iot as an enabler of the circular economy  circularity-by-design as an enabler for iot (ce-iot)

The overall aim of CE-IoT is to develop an innovative framework of interplay between Circular Economy and IoT, to explore novel ways in which this interaction can drastically change the nature of products, services, business models and ecosystems. The CE-IoT framework will be bi-dimensional and bi-directional in terms of circularity, aiming to develop (i) novel circular economy business models and service supply chains to unlock CE-IoT synergies in order to generate direct value for customers/end-users and augmenting resource productivity across economies by forming new ecosystems that eliminate both negative externalities and the need for considerable resources altogether, and (ii) open, circular-by-design IoT architecture, where “smart” IoT objects (e.g., sensors, devices, systems and components) are integrated in the IoT ecosystem through patterns  with proven key circularity-enabling properties (scalable connectivity, end-to-end security/privacy, dependability and interoperability) to maximize IoT resource and data harvesting in a new breed of circular-by-design IoT ecosystems.
To achieve its overall aim, CE-IoT will undertake research and innovation activities to (i) establish a comprehensive framework with IoT as a key enabling and facilitating technology of the circular economy from a business perspective based on circular economy design patterns, (ii) to develop an open modular, circular-by-design IoT architecture based on IoT architectural design patterns and (iii) to integrate an overarching pattern-driven CE-IoT framework covering both business and technical aspects.
CE-IoT will carry out comprehensive evaluation of the CE-IoT framework covering business, technical and legal aspects through two demonstrators in the domains of telecommunication and cloud services and will create conditions for effectuating circular economy principles through seamless integration with IoT technology and to broaden the use of the CE-IoT framework.
SYSTEM AND METHOD FOR MEASURING A SURFACE IN CONTOURED GLASS SHEETS

An optical inspection system is provided for an ultraviolet laser and associated optics forming a planar laser sheet directed to a glass sheet. The planar laser sheet intersects a surface of the glass sheet thereby causing the surface of the glass sheet to fluoresce and form a visible wavelength line on the surface. A camera has an image sensor for detecting the visible wavelength line. A control system is configured to receive image data indicative of the visible wavelength line, analyze and triangulate the data to determine a series of coordinates associated with the line, and create a three-dimensional map of the surface of the glass sheet as a function of the series of coordinates. Methods for using an optical inspection system, for gauging a surface using an optical inspection system, and for providing optical reflectance information for a surface using an optical inspection system are also provided.
MONOFILAMENTS FROM POLYMER BLENDS AND FABRICS THEREOF

A monofilament which exhibits improved hydrolytic stability properties as compared to conventional polyester monofilaments is formed from the extrusion of a blend of PPS and at least one polymer selected from the group consisting of PET, a high temperature polyester resin and polyphenylene oxide and possibly, a hydrolytic stabilizing agent. The monofilament is produced without the inclusion of compatibilizers or fillers, even though PPS is known to be incompatible with PET and high temperature polyester resins in most applications. A fabric may be produced having increased resistance to hydrolytic degradation and includes a plurality of woven monofilaments, comprising a blend of PPS with at least one other polymer selected from the group consisting of PET, a high temperature polyester resin and polyphenylene oxide and, a hydrolytic stabilizing agent. Such fabrics have utility as fabrics for the dryer sections of paper machines. Methods for the production of such monofilaments are also provided.
The Relationship between Voluntary Disclosure, External Financing and Financial Status

Using unique Swedish disclosure data from 2007 to 2012, this paper reports three important sets of findings with regard to the relationship between firms’ voluntary disclosure, external financing and financial status. First, financially strong firms disclose more than weaker ones. Second, firms that obtain new financing (equity or debt) disclose more than firms that do not. Third, the association between voluntary disclosure and financing events is stronger in financially weak firms. This last finding is new in the literature. Perhaps financially weak firms that obtain external funding have higher disclosure to counteract contracting and valuation problems in the financial markets.
Sensors and certifiable hybrid architectures for safer aviation in icing environment

Modern aeroplanes are well equipped to cope with most common icing conditions. However, some conditions consisting of supercooled large droplets (SLD) have been the cause of tragic accidents over the last three decades. It was proven that there are certain types of aircraft which are not robust against these conditions as ice can form on unprotected areas of the lifting surfaces leading to loss of control. Consequently, authorities addressed these safety concerns by issuing new certification rules under Appendix O to ensure that future aircraft remain controllable in these conditions and can exit safely upon detection. Hence, the key to increasing overall aviation icing safety is the early and reliable detection of icing conditions to allow the necessary actions to be taken by the flight crew. SENS4ICE (SENSors and certifiable hybrid architectures for safer aviation in ICing Environment) directly addresses this need for reliable detection and discrimination of icing conditions. It proposes that an intelligent way to cope with the complex problem of ice detection is the hybridisation of different detection techniques: direct sensing of atmospheric conditions and/or ice accretion on the airframe, combined with indirect techniques in which the change of aircraft characteristics with ice accretion on the airframe is detected. SENS4ICE will address the development, test, validation, and maturation of the different detection principles, the hybridisation - in close cooperation with regulators to provide an acceptable means of compliance - and the final airborne demonstration of technology capabilities in relevant natural icing conditions. The contribution of SENS4ICE to increase aviation safety will be achieved by an international consortium of 20 partners (13 EU, 7 non-EU) with contributions from Brazil, Canada, Russia and the US. The 4-year project requests an overall EU-funding of 6.6M€ and benefits from a further 5.4M€ of activities being provided by the non-EU partners.
Growth balance regulation by snrk1 under aba-stress conditions

In response to adverse environmental conditions, such as water scarcity, extreme temperatures or salinity plants trigger responses that promote stress tolerance and survival at the expense of growth. Despite the negative impact of stress on crop productivity how growth is modified by stress signalling pathways is largely unknown. One major component of the response to the most devastating stresses is ABA, a hormone that triggers cellular and whole-plant adaptive mechanisms via the activation of SnRK2 protein kinases. Another major player is the energy sensing SnRK1 protein kinase, which promotes plant stress tolerance and survival through the vast regulation of metabolism and gene expression. Preliminary results in the host lab have revealed deficient ABA responses in a partial SnRK1 loss-of-function mutant as well as the physical interaction between SnRK1 and the ABA-activated SnRK2 kinases, suggesting a functional connection between these two pathways. Furthermore, SnRK1 and SnRK2 have recently been implicated in the repression of a central growth regulator, the TOR (Target of Rapamycin) protein kinase. The aim of this proposal is to investigate the interaction between these two major stress-related kinases (SnRK1 and SnRK2) and to elucidate the mechanism(s) by which they modulate growth-promoting signalling pathways in response to ABA. To tackle the functional relevance of the SnRK1-SnRK2 connection, a combination of biochemical approaches, genetics, microscopy, cell-based assays and chemical genomics will be used. To identify growth regulators downstream of the SnRK axis, targeted analyses of TOR readouts will be employed in combination with unbiased analyses of SnRK1 interactors and substrates in ABA. Altogether this project will provide novel molecular insight on the trade-offs between stress tolerance and growth/yield that may potentially contribute to more successful crop improvement.
Classification of RNA sequences with pseudoknots using features based on partial sequences

Classification on pseudoknots existence is a challenging and meaningful problem in Bioinformatics. As predicting RNA secondary structures with pseudoknots is NP-complete problem while predicting pseudoknot-free structures can be done in O(n3) time, if a preliminary pseudoknots existence classification of RNA sequence can be done before the prediction, the classification result can enhance the efficiency of RNA secondary structure prediction. In this paper, a classification of the existence of pseudoknots in an RNA sequence is presented. A set of features have been chosen by partial sequence content and thousands of RNA sequences with validated structures are used to train the classifier. Using a validated testing dataset, this classification method is shown to achieve a very good performance that the best result get 87% accuracy in 10-fold cross validation and around 75% accuracy in testing data. Moreover it may reveal how partial sequence content can affect the formation of pseudoknots.
A Historical Study of Self-Combing Women in Singapore

Self-combing women (自梳女) is the name for some special women who decided to stay single in whole life. The most representative ones were the women from Shunde and Panyu counties in the province of Guangdong,China,from late 19th century to the middle of 20th century. The motive for self-combing is rather complex,so was their life very rough.The journey they took to the South Sea to take up the jobs as maids in the service industry had given them a particular name—majie. In Singapore,very few majie had made it back to their hometown in China when they got old. Most spent their whole life in Singapore.
Advanced fibre-reinforced polymer (FRP) composite materials in bridge engineering: materials, properties and applications in bridge enclosures, reinforced and prestressed concrete beams and columns

Abstract: Chapters 16 and 17 discuss the development of the advanced polymer composite material applications in bridge engineering. They demonstrate the innovative types of components and structures which have been developed from FRP composite materials and the most advantageous way to employ composites in bridge engineering. Given the importance of bridge infrastructure, the discussion of this topic has been split over two chapters. This chapter focuses on the type of FRP composite materials used in bridge engineering, their in-service properties and their applications in bridge enclosures and the rehabilitation of reinforced and prestressed concrete bridge beams and columns. Chapter 17 covers rehabilitation of metallic bridge structures, all FRP composite bridges and bridges built with hybrid systems.
Market-Wide Price Co-movement around Crashes in the Tokyo Stock Exchange

As described in this paper, we study market-wide price co-movements around crashes by analyzing a dataset of high-frequency stock returns of the constituent issues of Nikkei 225 Index listed on the Tokyo Stock Exchange for the three years during 2007–2009. Results of day-to-day principal component analysis of the time series sampled at the 1 min time interval during the continuous auction of the daytime reveal the long range up to a couple of months significant auto-correlation of the maximum eigenvalue of the correlation matrix, which express the intensity of market-wide co-movement of stock prices. It also strongly correlates with the open-to-close intraday return and daily return of Nikkei 225 Index. We also study the market mode, which is the first principal component corresponding to the maximum eigenvalue, in the framework of Multi-fractal random walk model. The parameter of the model estimated in a sliding time window, which describes the covariance of the logarithm of the stochastic volatility, grows before almost all large intraday price declines of less than −5%. This phenomenon signifies the upwelling of the market-wide collective behavior before the crash, which might reflect a herding of market participants.
PROmoting regional Sustainable Policies on Energy and Climate change mitigation Towards 2030

PROSPECT2030 tackles the challenges related to the transition towards a low-carbon economy and the adoption of climate change mitigation policies that all Central Europe Regions are facing. The project is based on the belief that Regions should be the hub for a radical rethink of public fund use and energy planning approach in a more decentralized and smart way. Its main objective is thus to boost the capacity of involved Regions in mobilising investments addressed to reach 2030 energy objectives at territorial level in a more efficient way with an increased cost-effectiveness than in the past. Despite taking into account the existing planning and public fund legislation framework in each region, the project will provide an innovative pathway by interconnecting energy planning with economic, financial and technical aspects. The project starts with the evaluation of the 2014-20 investments for low carbon and follows with an energy planning activity with an holistic view toward 2030 for a set of 2-3 key low carbon technologies, identified in each region with a participative stakeholders consultation. The outcomes of these activities will address the use of public funds for the next programming period, assuring project durability. In this way the investments supported in the future will lead to “Sustainable Energy Regions”, also creating new job opportunities. The delivery of policy recommendations on use of public funds will be drafted with the intent to mainly influence the macro regional strategies insisting in Central Europe. In addition 7 regional Energy Action Plans, online training packages and the replication campaign will guarantee the project replicability, as a wide number of stakeholders, in addition to the partnership, will benefit from project main outputs. The transnational capacity building activity will ease the mutual learning process, while an effective communication campaign will spread out project results and boost the project transferability.
THERMALLY INSULATIVE ATTACHMENT

A thermally insulative component is a thermal barrier panel attached to a rigid structural member with means for attaching the insulative component to an external structure. The connection between the structural member and the thermal barrier panel is mechanically compliant to minimize intercomponent stress build up during operation. The thermal barrier panel is a fiber wrapped ceramic oxide foam insulating structure.
Drivers of soil bacterial community structure and diversity in tropical agroforestry systems

Abstract Agroforestry systems (AFSs) are considered sustainable forms of land management, but their impact on soil microbial biodiversity remains poorly understood. Here, we compared the structure and diversity of bacterial communities in rubber-based AFSs in tropical China that had different management types and stand ages: 10-year-old rubber mono- (YR) and intercropping (YRF), and 22-year-old rubber mono- (MR) and intercropping (MRF). Stand age had a stronger effect on bacterial communities than management type or season. Compared to the corresponding monocultures, YRF maintained bacterial diversity despite experiencing a decrease in abundance, especially at soil depths of 0–5 and 5–30 cm, whereas MRF enhanced bacterial diversity with a consistent abundance. Bacterial communities in AFSs exhibited obvious horizon-specific seasonal variations due to spatial and temporal heterogeneity in edaphic factors. Acidobacteria, Proteobacteria and Actinobacteria were the most dominant bacterial phyla in tropical AFSs in China, while Kitasatospora, Streptomyces, Nitrospira, Bacillus and Pseudomonas were the key genera. Soil pH, available phosphorus and dissolved organic nitrogen emerged as the major drivers of these bacterial community patterns. These findings indicate that the establishment of rubber-based AFSs, particularly those in mature stands, is a promising management practice for alleviating the adverse effects of rubber monoculture on bacterial biodiversity, including severe acidification and nutrient depletion. Our study highlights the importance of considering multiple effects when investigating bacterial communities in AFSs under climate change scenarios.
ELSL – GESELLSCHAFT MIT BESCHRÄNKTER HAFTUNG

ELSL – GESELLSCHAFT MIT BESCHRÄNKTER HAFTUNG – MASSNAHMEN 3.1.1 UND 3.2.1 – LIGURISCHE NICHT KOMPLEXE INDUSTRIEKRISENBEREICHE
GEOM. SIMONE PELASSA

THIS IS A PROFESSIONAL TECHNICAL STUDY STARTED SINCE 2001, COMPOSED OF THE OWNER SURVEYOR ENROLLED IN THE REGISTER AND ASSISTANT MEMBER OF ANCH’S REGISTERED ASSISTANT, HEADQUARTERED IN IMPERIA, VIA NAZIONALE N.337, TWO PC STATIONS ONE FIXED AND ONE MOBILE AND A NEWLY RENOVATED TOPOGRAPHICAL INSTRUMENTATION. HE CARRIES OUT THE ACTIVITY OF THE SURVEYOR OF DESIGN, MANAGEMENT OF THE WORKS, SAFETY IN CONSTRUCTION SITES, URBAN CADASTRAL PRACTICES AND LAND, THOUSANDTH TABLES, ENERGY CERTIFICATION PRACTICES AND FOR OBTAINING TAX DEDUCTIONS, REGISTRATION IN THE REGISTER OF ASBESTOS MANAGERS AND ENERGY CERTIFIERS, IN COMPLIANCE WITH CREDITS RELATED TO CONTINUOUS TRAINING.
Automated GMP production and long-term experience in radiosynthesis of CB<sub>1</sub> tracer [<sup>18</sup> F]FMPEP-<i>d</i> <sub>2</sub>

Here, we describe the development of an in-house-built device for the fully automated multistep synthesis of the cannabinoid CB1 receptor imaging tracer (3R,5R)-5-(3-([18F]fluoromethoxy-d2)phenyl)-3-(((R)-1-phenylethyl)amino)-1-(4-(trifluoromethyl)phenyl)pyrrolidin-2-one ([18F]FMPEP-d2), following good manufacturing practices. The device is interfaced to a HPLC and a sterile filtration unit in a clean room hot cell. The synthesis involves the nucleophilic 18F-fluorination of an alkylating agent and its GC purification, the subsequent 18F-fluoroalkylation of a precursor molecule, the semipreparative HPLC purification of the 18F-fluoroalkylated product, and its formulation for injection. We have optimized the duration and temperature of the 18F-fluoroalkylation reaction and addressed the radiochemical stability of the formulated product. During the past 5 years (2013–2018), we have performed a total of 149 syntheses for clinical use with a 90% success rate. The activity yield of the formulated product has been 1.0 ± 0.4 GBq starting from 11 ± 2 GBq and the molar activity 600 ± 300 GBq/μmol at the end of synthesis.
Lead exposure from soil in Peruvian mining towns: a national assessment supported by two contrasting examples

To estimate the population of Peru living in the vicinity of active or former mining operations that could be exposed to lead from contaminated soil.Geographic coordinates were compiled for 113 active mines, 138 ore processing plants and 3 smelters, as well as 7743 former mining sites. The population living within 5 km of these sites was calculated from census data for 2000. In addition, the lead content of soil in the historic mining town of Cerro de Pasco and around a recent mine and ore processing plant near the city of Huaral was mapped in 2009 using a hand-held X-ray fluorescence analyser.Spatial analysis indicated that 1.6 million people in Peru could be living within 5 km of an active or former mining operation. Two thirds of the population potentially exposed was accounted for by 29 clusters of mining operations, each with a population of over 10 000 each. These clusters included 112 active and 3438 former mining operations. Soil lead levels exceeded 1200 mg/kg, a reference standard for residential soil, in 35 of 74 sites tested in Cerro de Pasco but in only 4 of 47 sites tested around the newer operations near Huaral.Soil contamination with lead is likely to be extensive in Peruvian mining towns but the level of contamination is spatially far from uniform. Childhood exposure by soil ingestion could be substantially reduced by mapping soil lead levels, making this information public and encouraging local communities to isolate contaminated areas from children.