SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Coenzyme a – launch of in vivo experiments

Acies Bio is looking to hire an expert on disease model development – particularly whole organism models in fruit flies – to join our drug discovery team developing 4-phosphopantetheine-related compounds for treating a range of Coenzyme A (CoA) metabolism related pathologies. Acies Bio’s lead compound is able to directly manipulate cellular CoA levels, which addresses the common underlying cause of this class of diseases. High therapeutic potential of this innovative treatment has been demonstrated for pantothenate-kinase-associated neurodegeneration (PKAN) and has resulted in the European Medicines Agency granting our lead compound orphan medicinal product designation. Application of this class of compounds to related diseases forms a core part of our Innovation Strategy, and could have far reaching implications in diverse areas such as numerous rare metabolic diseases, Alzheimer's disease and diabetes. This would not only make treatment available to a wider population of patients, suffering from currently untreatable conditions, but also open new opportunities for Acies Bio. Despite being world leaders in the field of CoA metabolism, as evidenced by our contribution to the TIRCON consortium, prior recruitment of relevant expertise has been hindered by obstacles within the national labour market. Hence, this call affords a valuable opportunity to recruit an Innovation Associate, to evaluate existing models in fruit flies, develop new disease models, implement novel phenotypic assays, and lead a dedicated facility. Acies Bio will provide outstanding coordination and support facilities, state-of-the-art chemical synthesis and analytics laboratory and a research-driven, commercial environment. Successful completion of this crucial step for proof-of-concept in alternative metabolic diseases, will accelerate patent protection and market approval of these ground-breaking therapeutics.
Faculty Stress at Higher Education: A Study on the Business Schools of Pakistan

Job stress is one of the most important concepts for the today's corporate as well as institutional world. The current study is conducted to identify the causes of faculty stress at Higher Education in Pakistan. For the purpose, Public & Private Business Schools of Punjab is selected as representative of Pakistan. A sample of 300 faculty members (214 males, 86 females) responded to the survey. Regression analysis shows that the Workload, Student Related issues and Role Conflicts are the major sources contributing significantly towards producing stress. The study also revealed that Private sector faculty members experienced more stress as compared to faculty in Public sector Business Schools. Moreover, females, younger ages, lower designation & low qualification faculty members experience more stress as compared to males, older ages, higher designation and high qualification. The study yield many significant results for the policy makers of Business Institutions.
Quelques notes à propos de l’olivier dans la chanson de geste

Abstraite L’olivier est toujours un élément silencieux de la chanson de geste au Moyen Âge. La France septentrionale a précocement développé, aux XII-XIII siècles, une littérature épique qui se focalise sur les héros de la cour de Charlemagne. Les paladins du roi sont toujours engagés dans la lutte contre les infidèles, soit les Sarrasins soit les vassaux rebelles. Outre le courage et la force, ces guerres requièrent diplomatie et stratégie. Par conséquent, avant les conflits, le roi rassemble ses héros sous un olivier pour organiser la guerre. L’olivier devient un objet de bon augure pour la bataille, chargé de symbolisme religieux, en rappelant les prières de Jésus Christ dans le jardin de Gethsémani, la nuit de la Dernière Cène. Dans l’article, on essayera d’écrire une histoire du rôle de l’olivier dans la chanson de geste, en essayant de préciser les différents rôles de l’arbre.
Padé approximants of special functions

Let $ {f_{\gamma }}(x) = \sum\nolimits_{{k = 0}}^{\infty } {{{{T_k (x)}} \left/ {{{{\left( \gamma \right)}_k}}} \right.}} $
 , where (γ)
 k
 =γ(γ+1) ⋯ (γ+k−1) and T
 k
 (x)=cos (k arccos x) are Pade–Chebyshev polynomials. For such functions and their Pade–Chebyshev approximations $ \pi_{n,m}^{ch}\left( {x;{f_{\gamma }}} \right) $
 , we find the asymptotics of decreasing the difference $ {f_{\gamma }}(x) - \pi_{n,m}^{ch}\left( {x;{f_{\gamma }}} \right) $
 in the case where 0 ⩽ m ⩽ m(n), m(n) = o (n), as n→∞ for all x ∈ [−1, 1]. Particularly, we determine that, under the same assumption, the Pade–Chebyshev approximations converge to f
 γ
 uniformly on the segment [−1, 1] with the asymptotically best rate.
Analyzing Seismic Destructive Effect to the Submarine Rock and Soil Layers According to Submarine Seismic Records

By means of survey and study, various submarine seismic records were identified in the marine facies strata from Sinian Period to Ordovician Period in Tancheng-Lujiang seismic fault zone and its vicinity. These submarine seismic records are divided into two classes. According to the mode of seismic action, every class of submarine seismic records is divided into three to four types. On the basis of classification, this paper studied and summarized seismic destructive effects to the submarine rock and soil layers and diagrammatized mechanism and process of seismic destructive effects. Seismic destructive effects to soft sedimentary soil strata mainly include seismic vibratory liquefaction, vibratory thixotropic effect, seismic fold deformation, sliding deformation, tensile deformation and combined action of shaking and weight. Seismic destructive effects to submarine soil strata of semi-consolidated to un-completely consolidated sediments mainly include syn-sedimentary fault effect, crack and smashing effect, filling effect of seismic crack, etc.
Liberating Imagination and Other Ends of Medieval Jewish Philosophy

Abstract In its treatment of imagination as understood by medieval Jewish philosophers, modern scholarship has tended to neglect the intersection of animal fables and political thought. This paper examines several Aesopian themes in Greek philosophy and medieval Jewish philosophic literature, especially the tales composed by Berakhiah ha-Naqdan, in order to highlight the attention lavished by these premoderns on the faculty of imagination. It is argued that, according to the philosophers, human perfection requires the cultivation of both intellect and imagination. It is also shown that Pierre Hadot’s notion of “spiritual exercises” as constituting philosophy is fruitfully applicable to the genre of fable.
Smart control of the climate resilience in european coastal cities

The intensification of extreme weather events, coastal erosion and sea-level rise are major challenges to be urgently addressed by European coastal cities. The science behind these disruptive phenomena is complex, and advancing climate resilience requires progress in data acquisition, forecasting, and understanding of the potential risks and impacts for real-scenario interventions. The Ecosystem-Based Approach (EBA) supported by smart technologies has potential to increase climate resilience of European coastal cities; however, it is not yet adequately understood and coordinated at European level. SCORE outlines a co-creation strategy, developed via a network of 10 coastal city ‘living labs’ (CCLLs), to rapidly, equitably and sustainably enhance coastal city climate resilience through EBAs and sophisticated digital technologies. SCORE will establish an integrated coastal zone management framework for strengthening EBA and smart coastal city policies, creating European leadership in coastal city climate change adaptation in line with The Paris Agreement. The Coastal City Living Lab (CCLL) is a new concept that expands the Living Lab approach to coastal cities and settlements. CCLLs will be set up to address specific climate challenges, and their effectiveness will be assessed by different stakeholders through innovative monitoring systems and cutting-edge modelling approaches. SCORE will develop CCLLs in a network of 10 cities which learn from each other in different frontrunner and follower roles. SCORE will involve citizen science in providing prototype coastal city early-warning systems and will enable smart, instant monitoring and control of climate resilience in European coastal cities through open, accessible spatial ‘digital twin’ tools. SCORE will provide innovative platforms to empower stakeholders’ deployment of EBAs to increase climate resilience, business opportunities and financial sustainability of coastal cities.
On the Alleged Indebtedness of the Vedānta Paribhāṣā Towards the Vedānta Kaumudī: Some Considerations on an Almost Forgotten Vivaraṇa Text (Studies in Vedānta Kaumudī I)

Dharmarāja Adhvarin’s (middle XVII cent.) Vedānta Paribhāṣā (VP) is a well-known introduction to Advaita Vedānta, targeted to beginners who are already trained in Navya Nyāya. According to Dasgupta (1942), the VP is so heavily indebted to Rāmādvaya’s Vedānta Kaumudī (VK), which was composed in the middle of the 14th century and is today almost forgotten, that the VP’s “claim to originality vanishes”. The VK was, however, only edited in 1955 and then again in 1973. In the light of this improved textual basis, what is our judgement about Dasgupta’s hypercritical statement? Did actually the VP ever claim to be original? Was this originality somehow superimposed on the VP later? Is the VP really so much indebted to the VK? This paper aims at comparatively analysing the textual background of these questions. I will start from the analysis of one Advaita’s epistemological tenet, namely the valid knowledge (pramā), in the VK and then compare it to the corresponding parts in the VP.
All-Weather snow machine driven by renewable energy sources

The ski business and mountain economy depend on the randomness of snowfalls. Climate change is shortening the ski season because of less snow precipitation and of higher average winter temperature. Ski resorts have to counteract the lack of natural snow, and to guarantee the opening of ski district in the most touristic periods. Current snowmaking techniques (fans and cannons) require an air temperature below 0°C and low humidity, thus are not applicable for large part of the season. NeveXN developed a technology able to produce high quality snow at temperatures above 0°, in all weather condition and without any chemical additives. SnowRESolution is a clean-tech snowmaker that works also when traditional snowmakers cannot be operated. The technology is based on the refrigeration cycle and exploits the triple point of water, a condition that occurs at 0°C and almost in vacuum (6mbar) at which the three phases of ice, liquid, and vapour are in equilibrium. The compressor is driven by thermal energy that is provided by renewable energy sources, which may be either a solar thermal collector or a biomass steam boiler. Winter tourism is very important in all mountain regions, and risk to undergo to huge losses if slopes are bare. SnowRESolution address the market of ski resorts that want to guarantee the production of snow also when ambient temperature is above 0°C, enabling an early opening of the ski season. Interest savings opportunities are offered to ski domes that do no need any additional cooling to produce snow and can chose the solar power supply solution.
Not With Impunity: Assessing U.S. Policy for Retaliating to a Chemical or Biological Attack

Abstract : How should the United States determine its response to a chemical or biological attack against American personnel or interests? This paper assesses the current U,S reprisal policy known as calculated ambiguity and concludes that today's policy does not contain enough substance to support strategy development. Current policy is designed to deter chemical and biological attacks by threatening an overwhelming and devastating response, with the strong implication that nuclear weapons may be employed in the U.S. response. The current policy is inadequate because it lacks credibility, it fails to address proportionality, and it focuses on state actors, To improve the policy's efficacy, two clarifications are needed: make regime survivability the hallmark of the policy, and determine under what conditions nuclear weapons would be considered. The paper concludes by presenting an analytical framework for determining the U.S. response should deterrence fail.
On the relationship between Early-to-Late Ratio of Room Impulse Responses and ASR performance in reverberant environments

Study on the correlation between ASR accuracy and reverberant acoustic conditions.Experiments involve a large variety of simulated and measured room impulse responses.The best duration of early arrivals is determined experimentally.The approach is applied to data contamination for acoustic model training and model selection.A large vocabulary recognition task (WSJ) is considered using both GMM and DNN. This work presents an experimental analysis of distant-talking speech recognition in a variety of reverberant conditions, correlating ASR performance to a compact representation of the propagation channel (i.e., the room impulse response).It is well known that reverberation and background noise degrade speech recognition performance, but few studies have investigated the relation between room impulse responses and recognition rates in a comprehensive manner. In particular, we show how the ASR accuracy is related to features derived from the structure of the early arrivals and the reverberation tail. A representation based on the combination of few parameters is hence proposed, analysing the impact of reverberation on different speech recognition tasks. Possible applications of the derived measure are in data contamination for acoustic modeling where this feature can be employed either to select the most suitable model for a given acoustic condition or to define the subset of room impulse responses to be used for the creation of partially matched reverberant models. Recognition results using different back-end solutions (GMM, DNN) on data generated with the image method and with real impulse responses validate the effectiveness of the approach.
KINASE KNOCKDOWN VIA ELECTROPHILICALLY ENHANCED INHIBITORS

Provided herein are electrophilically enhanced kinase inhibitors. Also provided herein are methods of making and utilizing the same.
FORCE TRANSDUCER FOR A VEHICLE SEAT

The invention relates to a force transducer (2) which is used to receive the applied force of weight in the mounting of a vehicle seat, comprising a force input element (4) in the vehicle seat, a force output element (7) connected to the mounting and an extension body (5) disposed in between the force input element (4) and the force output element (7), which allows for precise measurement of the applied force of weight in the mounting of the vehicle seat, irrespective of other force factors. The force input element (4) or the force output element (7) surrounds the extension body (5) on a level which is parallel to that of the weight force when exerted. At least one extension-measuring strip (9) is arranged on the extension body (5). Said strip absorbs the shear force parallel to the weight force.
Single-Cell transcriptomics and spliceosome analysis to uncover new mechanisms of neuronal vulnerability to huntington’s disease.

Huntington’s disease (HD) is neurodegenerative disease caused by a CAG repeat expansion mutation in the HTT gene. The pathological process, which ultimately leads to neuronal loss mainly in the caudate and putamen, is induced - in a truly dominant manner - by a single copy of the mutant allele. Transcriptional deregulation has becoming a prevailing feature in HD and changes at single-gene level in RNA biogenesis and aberrant alternative splicing (AS) events have been associated to neuronal vulnerability. Here, I propose to disentangle at genome-wide level the connections between mutant huntingtin expression and RNA processing, and its implications for neuronal vulnerability to death. Specifically, I propose to study alterations in RNA transcription and AS in: Aim 1. Striatal, cortical and cerebellar areas of Hdh knock-in (KI) HD accurate mouse models through global RNAseq; Aim 2. In specific medium spiny neurons (MSN) of the Drd1 or Drd2 direct and indirect pathways of Hdh KI striatum through laser capture dissection and single-cell RNAseq. 
The present research proposal represents a synthesis of my interest, expertise in RNA regulation, genome-wide approaches and single-cell analysis in the context of neurodegenerative disorders with my most recent exposure to human genetic. On the other hand, at the CIBIO host institution I will greatly benefit from the scientific exchange with the PIs of the neurobiology area, and my supervisor in particular, whose skills in neuroscience, neuroanatomical and behavioral analyses will perfectly blend and consolidate my cellular and molecular expertize. Thus, I believe I am optimally positioned to accomplish the aims of the current application: the MSCA-RI-IF will be instrumental to develop this initial hypothesis into deeper biological understanding of HD and represent a crucial support to my scientific integration as a competitive, woman investigator in the transition from postdoctoral training to an independent academic career.
Noise-induced effects in nonlinear relaxation of condensed matter systems

Abstract Noise-induced phenomena characterise the nonlinear relaxation of nonequilibrium physical systems towards equilibrium states. Often, this relaxation process proceeds through metastable states and the noise can give rise to resonant phenomena with an enhancement of lifetime of these states or some coherent state of the condensed matter system considered. In this paper three noise induced phenomena, namely the noise enhanced stability, the stochastic resonant activation and the noise-induced coherence of electron spin, are reviewed in the nonlinear relaxation dynamics of three different systems of condensed matter: (i) a long-overlap Josephson junction (JJ) subject to thermal fluctuations and non-Gaussian, Levy distributed, noise sources; (ii) a graphene-based Josephson junction subject to thermal fluctuations; (iii) electrons in a n-type GaAs crystal driven by a fluctuating electric field. In the first system, we focus on the switching events from the superconducting metastable state to the resistive state, by solving the perturbed stochastic sine-Gordon equation. Nonmonotonic behaviours of the mean switching time versus the noise intensity, frequency of the external driving, and length of the junction are obtained. Moreover, the influence of the noise induced solitons on the mean switching time behaviour is shown. In the second system, noise induced phenomena are observed, such as noise enhanced stability (NES) and stochastic resonant activation (SRA). In the third system, the spin polarised transport in GaAs is explored in two different scenarios, i.e. in the presence of Gaussian correlated fluctuations or symmetric dichotomous noise. Numerical results indicate an increase of the electron spin lifetime by rising the strength of the random fluctuating component. Furthermore, our findings for the electron spin depolarization time as a function of the noise correlation time point out (i) a non-monotonic behaviour with a maximum in the case of Gaussian correlated fluctuations, (ii) an increase up to a plateau in the case of dichotomous noise. The noise enhances the coherence of the spin relaxation process.
A SUBSTRATE IMPREGNATED WITH TITANIUM DIOXIDE NANOPARTICLES.

A material is produced comprising a substrate, which may be cloth, impregnated titanium dioxide nano particles. The cloth may be formed into Venetian blinds. It may also be used to line parts of ultra violet light air conditioning apparatus. This cloth may be plane or pleated.
Strateški menadžment u uvjetima globalizacije poslovanja

Numerous changes in various fields, especially in the economy of last decades, are directly linked to the process of globalization. Due to these changes, companies have been forced to internationalize their activities because reliance on the domestic market brings mere survival into question. In business globalization, where the business environment is defined by differences brought by the boundaries of national states, the role of strategic management is to formulate a coherent, coordinated, integrated and unified strategy for the company to globalize its strategic behavior in different countries. In this paper, the author explores and analyzes the theoretical assumptions of globalization and global strategic management, and how the international or global strategy of enterprise growth affects its market position and neutralization of the risks arising from such key decisions. The conducted research and analysis of authors` findings show that the success of a global development strategy of a company is linked to the degree of appreciation of the various regional uniquenesses of individual countries and that Croatian companies, especially those in manufacturing, are not able to formulate or realize their global strategies without the prior improvement of the international competitiveness of the Republic of Croatia.
METHOD FOR PRODUCING CONTROLLED RHEOLOGY POLYPROPYLENE, POLYPROPYLENE, USE THEREOF AND MANUFACTURED ARTICLES

The present invention relates to a method for producing a controlled rheology polypropylene characterised in that it comprises a step of mixing a propylene polymer with at least one organic low-reactivity peroxide. The polypropylene having the rheology according to the present invention can be used for producing fibres, in melt-blown processes, hot-melt adhesives, spun-bonded and injection-moulded articles.
Improving Structural Funds for better delivery of R&D&i policies

The IMPROVE project brings together partners from 8 regions with different background in terms of geographic area, economic development, innovation performance, more or less centralised administration system and responsibility for the management of the addressed policies, with the aim of improving the effectiveness of Structural Funds Programmes dedicated to build up R&D&I policies and support the implementation of Smart Specialisation Strategies.

The policy instruments addressed by the project are mainly Structural Funds Programmes, except for 2 Municipal Development Plans, which have the common goal of enhancing a knowledge-based regional/municipal economic growth. Thus, IMPROVE will positively contribute to regional smart, sustainable and inclusive development by strengthening the effectiveness of policies/programmes to support Research, Technological Development and Innovation in the participating regions.

IMPROVE is designed to foster the exchange of practices, experiences and knowledge and increase the capacities of partners and stakeholders involved, taking into consideration their profiles and regional interests. To this end it will address common challenges with regards to: 1) framework, policy mix and instruments for the delivery of R&D&I policies and the implementation of smart specialisation strategies 2) coordination with other Funds managed at regional/national/European level 3) transnational coordination 4) governance and 5) monitoring and evaluation.

The project will improve 8 policy instruments and ensure its long-term impact involving the managing authorities in the interregional learning process, both as partners and stakeholders. The project´s main activities are: 1) analysis of the regional state of the art regarding Structural Funds management and implementation 2) exchange of experiences by means of Peer Reviews, identification of Good Practices and Interregional Thematic Workshops and 3) transfer of knowledge and experiences to the regions.