SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Resource-Efficient circular product-service systems

The overall goal of ReCiPSS is to explore success factors for circular manufacturing systems in two cases where OEMs have different levels control over their value chains: one case with full control, and one case with partial control. The project will achieve this goal through two industry-driven large-scale demonstrators of circular manufacturing systems in two key industries
The white goods demonstrator relates to a tightly connected value chain and will demonstrate the successful implementation of circular manufacturing systems where the OEM (Gorenje) is in full control of the entire product throughout all stages (i.e. design, manufacturing, forward supply chain, customer use phase, reverse supply chain, recovery activities and re-distribution). The demonstrator will develop and implement a pay-per-wash offering for 300 washing machines, using co-creation methods. Each washing machine will be refurbished twice and serve over 3 life cycles of 5 years. The generalization of this new business model should lead to additional revenues of €150M per year. 
The automotive spare parts demonstrator relates to a more complex value chain where the OEM (Bosch) does not have full control of the product throughout all stages. In order to demonstrate how third-party automotive remanufacturers can be effectively integrated in circular supply chains while keeping their independence from the OEM, the demonstrator will streamline the reverse logistics flow for 80,000 cores, enabling aftermarket stakeholders to close the loop by using a single service provider for reverse logistics. Cores will be identified and evaluated only once and then directly shipped to the final destination (remanufacturer), allowing cost savings of €5 per core i.e. potential savings of €175M per year if generalized throughout the industry. Co-creation workshops with stakeholders will ensure that the way the used cores are identified and transported is optimally aligned with the needs of all parties involved.
Lifetime co-morbidity of DSM-IV disorders in the US National Comorbidity Survey Replication Adolescent Supplement (NCS-A)

Background Research on the structure of co-morbidity among common mental disorders has largely focused on current prevalence rather than on the development of co-morbidity. This report presents preliminary results of the latter type of analysis based on the US National Comorbidity Survey Replication Adolescent Supplement (NCS-A). Method A national survey was carried out of adolescent mental disorders. DSM-IV diagnoses were based on the Composite International Diagnostic Interview (CIDI) administered to adolescents and questionnaires self-administered to parents. Factor analysis examined co-morbidity among 15 lifetime DSM-IV disorders. Discrete-time survival analysis was used to predict first onset of each disorder from information about prior history of the other 14 disorders. Results Factor analysis found four factors representing fear, distress, behavior and substance disorders. Associations of temporally primary disorders with the subsequent onset of other disorders, dated using retrospective age-of-onset (AOO) reports, were almost entirely positive. Within-class associations (e.g. distress disorders predicting subsequent onset of other distress disorders) were more consistently significant (63.2%) than between-class associations (33.0%). Strength of associations decreased as co-morbidity among disorders increased. The percentage of lifetime disorders explained (in a predictive rather than a causal sense) by temporally prior disorders was in the range 3.7–6.9% for earliest-onset disorders [specific phobia and attention deficit hyperactivity disorder (ADHD)] and much higher (23.1–64.3%) for later-onset disorders. Fear disorders were the strongest predictors of most other subsequent disorders. Conclusions Adolescent mental disorders are highly co-morbid. The strong associations of temporally primary fear disorders with many other later-onset disorders suggest that fear disorders might be promising targets for early interventions.
Pipeline Anchor Apparatus

A pipeline anchor apparatus is disclosed. The pipeline anchor apparatus provides left and right anchor units connected by a tie-down strap made of heavy-duty polyester or nylon webbing. The strap prevents the pipeline from floating in wet conditions. By flexibly conforming to the surface of the pipeline, the tie-down strap prevents denting of the pipeline which weakens the pipeline, contributing to pipeline bending. Each anchor unit provides an helix anchor attached to an anchor rod that is buried deep in the soil. The anchor rod is connected to an extension rod by means of a lower coupling. A tie-down bracket having a tubular body and a sleeve is carried by the extension rod. Each end of the tie-down strap is attached to the sleeve of a tie-down bracket of an anchor unit. The tie-down brackets may pivot about the extension rod to lessen stress as water forces the pipeline upwardly, against the tie-down strap. The sleeve of the tie-down bracket is radially outwardly from the axis of the tubular body. As a result, an upward force on the sleeve may force the tie-down bracket and extension rod away from the pipeline, thereby protecting the pipeline from denting and bending.
Natural integration of bionic limbs via spinal interfacing

Missing a limb leads to dramatic impairments in the capacity to move and interact with the environment and to a substantial worsening in quality of life. This deficiency is also associated with a large portion of the sensory-motor cortex facing neural deafness. Missing or damaged limbs can in principle be substituted by robotic limbs, connected to humans with neural interfacing. Despite massive research efforts, however, the bionic reconstruction of limbs currently faces important translational challenges. We aim at filling this gap between academic research and clinical impact with a patient-centric approach that synergistically combines breakthroughs in surgery (Aszmann), neural interfacing (Farina), and robotics (Bicchi). We propose to surgically create bio-connectors (compacted in a bio-hub) to access the spinal cord circuitries by using biological pathways of encoding and decoding neural information. Neural interfacing with the bio-hub will determine an input/output information flow with the spinal cord by decoding the activity of spinal neural cells (output) and stimulating transplanted biological afferent organs (input). The sensory-motor image of the missing limb emerging from this interfacing will be projected in soft robotic arms/legs that will embed kinematic synergies and tactile-proprioceptive functions, intimately matched with the neural sensory-motor synergies extracted from the bio-hub. In this way, Natural BionicS aims at creating a fully integrated, symbiotic replacement of human limbs with robotic parts that the user will feel and command as part of the body. This aim will be achieved with clinical translation aided by the establishment of a Bionic Clinical Board of the three PIs. Here the options of bionic reconstruction will be explored for each patient on a bi-monthly basis, the engineering solutions will be adapted to the clinical challenges, and patients will be identified who best profit from the radical new developments of Natural BionicS.
Evaluation of Soluble P-Selectin as a Marker for the Diagnosis of Deep Venous Thrombosis

Objective: The combination of D-dimer and Wells score can exclude, but not confirm, the diagnosis of deep venous thrombosis (DVT). Since thrombosis and inflammation are interrelated, we evaluated the combination of soluble P-selectin (sPsel) with other inflammatory biomarkers for the diagnosis of DVT. Methods: Sixty-two positive and one hundred and sixteen patients with negative DVT, by duplex scan, were prospectively evaluated for sPsel, D-dimer, C-reactive protein (CRP), microparticles (MPs; total, leukocyte, and platelet-derived and tissue factor positive microparticles), and clinical Wells score. Results: Biomarkers and clinical scores that differentiated DVT positives from negatives were sPsel (87.3 vs 53.4 ng/mL, P &lt; .0001), D-dimer (5.8 vs 2.1 mg/ L, P &lt; .0001), CRP (2.1 vs 0.8 μg/mL, P &lt; .0005), and Wells score (3.2 vs 2.0, P &lt; .0001). For MP analysis, platelet-derived MPs were found to differentiate DVT from negatives. Using multivariable logistic regression, a combination of sPsel and Wells score could establish the diagnosis of DVT (cut point ≥90 ng/mL + Wells ≥2), with a specificity of 96% and positive predictive value (PPV) of 100%, and could exclude DVT diagnosis (cut point ≤60 ng/mL and Wells &lt;2) with a sensitivity of 99%, a specificity of 33%, and a negative predictive value (NPV) of 96%. Conclusion: This study establishes a biomarker and clinical profile combination that can both confirm and exclude the diagnosis of DVT.
Prospects for detecting the 21 cm forest from the diffuse intergalactic medium with LOFAR

We discuss the feasibility of the detection of the 21cm forest in the diffuse IGM with the radio telescope LOFAR. The optical depth to the 21cm line has been derived using simulations of reionization which include detailed radiative transfer of ionizing photons. We find that the spectra from reionization models with similar total comoving hydrogen ionizing emissivity but different frequency distribution look remarkably similar. Thus, unless the reionization histories are very different from each other (e.g. a predominance of UV vs. x-ray heating) we do not expect to distinguish them by means of observations of the 21cm forest. Because the presence of a strong x-ray background would make the detection of 21cm line absorption impossible, the lack of absorption could be used as a probe of the presence/intensity of the x-ray background and the thermal history of the universe. Along a random line of sight LOFAR could detect a global suppression of the spectrum from z>12, when the IGM is still mostly neutral and cold, in contrast with the more well-defined, albeit broad, absorption features visible at lower redshift. Sharp, strong absorption features associated with rare, high density pockets of gas could be detected also at z~7 along preferential lines of sight.
Contentotopic mapping: the topographical organization of object knowledge in the brain

Our ability to recognize an object amongst many others is one of the most important features of the human mind. However, object recognition requires tremendous computational effort, as we need to solve a complex and recursive environment with ease and proficiency. This challenging feat is dependent on the implementation of an effective organization of knowledge in the brain. In ContentMAP I will put forth a novel understanding of how object knowledge is organized in the brain, by proposing that this knowledge is topographically laid out in the cortical surface according to object-related dimensions that code for different types of representational content – I will call this contentotopic mapping. To study this fine-grain topography, I will use a combination of fMRI, behavioral, and neuromodulation approaches. I will first obtain patterns of neural and cognitive similarity between objects, and from these extract object-related dimensions using a dimensionality reduction technique. I will then parametrically manipulate these dimensions with an innovative use of a visual field mapping technique, and test how functional selectivity changes across the cortical surface according to an object’s score on a target dimension. Moreover, I will test the tuning function of these contentotopic maps. Finally, to mirror the complexity of implementing a high-dimensional manifold onto a 2D cortical sheet, I will aggregate the topographies for the different dimensions into a composite map, and develop an encoding model to predict neural signatures for each object. To sum up, ContentMAP will have a dramatic impact in the cognitive sciences by describing how the stuff of concepts is represented in the brain, and providing a complete description of how fine-grain representations and functional selectivity within high-level complex processes are topographically implemented.
Tratamentos anti-hipertensivos usados na Estratégia de Saúde da Família dos municípios polos das macrorregiões de saúde de Pernambuco: um estudo transversal

Caracterizar os esquemas terapêuticos anti-hipertensivos e suas associações, usados pelos hipertensos cadastrados na Estratégia Saúde da Família dos municípios polos das macrorregiões do estado de Pernambuco. Trata-se de um estudo transversal descritivo e analítico, realizado numa amostra aleatória de hipertensos. Dos 334 hipertensos participantes do estudo, 144 tinham diabetes. A maioria (62,27%) residia em Recife e era do sexo feminino (68,56%). A idade média dos entrevistados foi de 64,1 ± 13,0 anos. Mais de 50% referiram o uso de diuréticos, sendo predominante o uso da hidroclorotiazida. Este grupo foi o mais presente em politerapia, enquanto os bloqueadores dos receptores de angiotensina, representados por losartana (34,45%), e os inibidores da enzima conversora de angiotensina (30,25%) eram mais usados em monoterapia; observou-se em Recife uma maior utilização dos últimos, enquanto nos polos do interior privilegiava-se os primeiros. Predominou a politerapia com dois anti-hipertensivos e a maioria das associações estava condizente com as diretrizes nacionais e internacionais. Foram identificadas algumas associações inadequadas, como de inibidor da enzima conversora de angiotensina com bloqueador dos receptores de angiotensina. O estudo ampliou o conhecimento dos esquemas de tratamentos anti-hipertensivos utilizados na atenção primária numa amostra representativa de uma população com vulnerabilidades socioeconômicas, numa área em que informações e observações ainda são escassas. O confronto entre prática real e recomendações visa favorecer a escolha adequada da farmacoterapia, sabendo que o controle pressórico é essencial para evitar a ocorrência de complicações.
Geoamenazas Hidro-Geomorfológicas en subcuencas de los Andes Costeros de Chile Semiárido

Se analiza la dinámica geomorfológica de cuencas y subcuenca de la Región de Coquimbo, Chile, para establecer las condiciones que generan los eventos de 'flashflood' de verano-otoño, asociado a eventos de precipitaciones extremas. Se consideran los eventos ENSO como antecedentes previos de precipitaciones extremas, de invierno. El trabajo realizado se sustenta en la geomorfología de las laderas, de las formas de depositación y de erosión, dinámica de lechos y canales, como formas heredadas desde el Mioceno y Pleistoceno con una condición dinámica actual, más su vinculación implícita al Antropoceno. Se realizó trabajo de fotointerpretación y modelación de proxies dinámicos de escurrimiento en las subcuencas. Los resultados fueron levantados y contrastados en terreno. Como resultados se estableció que en la cuenca Santa Gracia, se presenta dos secciones, denominadas como knickpoints (Knp 1 y 2), que marcan diferencias dinámicas. La subcuenca, del mismo nombre, drena hacia el curso principal en Knp1. A partir de este umbral geomorfodinámico y estructural, se establecen las áreas con amenazas de inundación, siendo identificada en el lecho del Holoceno, la localidad de Lambert, que histórica y recurrentemente es afectada por estos eventos hidrogeomorfológicos y potencialmente en el futuro, también.
NOVEL AEROSOL-GENERATING SUBSTRATE COMPRISING ANETHUM SPECIES

An aerosol-generating article (1000)(4000a,4000b)(5000) comprises an aerosol-generating substrate (1020), the aerosol-generating substrate formed of a homogenised dill seed material comprising dill seed particles, an aerosol former and a binder. The aerosol-generating substrate further comprises at least 100 micrograms of carvone per gram of the substrate, on a dry weight basis; and at least 2 micrograms of limonene per gram of the substrate, on a dry weight basis. The amount of carvone per gram of the substrate is no more than 50 times the amount of limonene per gram of the substrate.
A study on surface slant encoding in V1

Inter-ocular differences in spatial frequency occur during binocular viewing of a surface slanted in depth. Cortical cells with inter-ocular differences in preferred spatial frequency (dif-frequency cells) are expected to detect surfaces slanted in depth or vertical surface slant. Using our reaction-diffusion model, we obtain receptive fields and responses of simple cells in layer IV in cat V1. The dif-frequency cells in the model cortex have tilt in binocular receptive field but we show that tilt by itself does not indicate slant selectivity. We studied cell responses to binocular combination of spatial frequencies (SFs) by varying the SF ratio of the input gratings to the left and right eye in the range of 0.35 to 3. This range of SF ratio corresponds to surface slant variation of −85&#176; to 85&#176;. The mean binocular tuning hwhh (half width at half height) is 41&#176;. Except for a small number (2.5%) of cells, most dif-frequency cells respond almost equally well for fronto-parallel surfaces. In the literature cells with inter-ocular difference in preferred orientation (IDPO) were expected to encode horizontal surface slant. In the model cat V1 mean hwhh in binocular orientation tuning curve for cells with IDPO is 39&#176;. The wide binocular tuning width in dif-frequency cells and cells with IDPO imply that in cat V1 neither dif-frequency cells nor cells with IDPO detect surface slant.
Advanced hybrid theranostic nanoplatforms for an active drug delivery in the cancer treatment

Cancer is one of the leading causes of death worldwide. Great efforts are still necessary to individuate new therapeutic strategies aimed to reduce cancer recurrence and to define new potential adjuvant targets for inhibiting invasion and metastasis, two significant contributors to death among patients. The combination therapy based on the simultaneous administration of two or more pharmacologically active agents with different modes of action using nanocarriers for the delivery could represent an effective strategy for the treatment. The increase in efficacy of a therapeutic formulation is causally related to its ability to selectively target diseased tissue, overcome biological barriers, and smartly respond to the disease environment to release therapeutic agents. The increasing interest in the employment of nanostructured materials to medicine-related branches is attributable to its unique properties allowing highly efficient drug delivery, molecular sensing applicable in diagnosis, multiplex imaging, or construction of point of care therapeutic devices. This project aims at an establishment of a consortium consisted of Regional centre of advanced technologies and materials (part of Palacký University), The Institute of Science and Technology for Ceramics (part of CNR) and Maynooth University which will through a set of workshops, seminars and extensive exchange of early-stage researchers develop an efficient scientific cluster. The research of the cluster will aim the development of functional 3D dual-modality nanostructures for targeted drug delivery and cell imaging.
Startup of “CANDLE” burnup in a Gas-cooled Fast Reactor using Monte Carlo method

Abstract During the past decade, the CANDLE burnup strategy has been proposed as an innovative fuel cycle and reactor design for complete utilization of uranium resources. In this strategy the shapes of neutron flux, nuclide densities and power density distribution remain constant but the burning region moves in axial direction. The feasibility of this strategy has been demonstrated widely by using the diffusion technique in conjunction with nuclide transmutation equations. On the other hand since the Monte Carlo method provides the exact solution to the neutron transport, the Monte Carlo technique is becoming more widely used in routine burnup calculations. The main objective of this work is startup of CANDLE burnup in a Gas cooled Fast Reactor using a Monte Carlo burnup scheme. In this case only natural or depleted uranium is required for fresh fuel region. However, the construction of the first CANDLE core is faced with a big problem. In equilibrium state the burning region contains a spectrum of fission products as well as higher actinides. These isotopes are not easily available for constructing the initial CANDLE core. The solution is startup of a special reactor using the enriched uranium in starter zone. At the end of core life the fuel for the next core is produced with the composition close to the equilibrium state. An originally MCNP–ORIGEN linkage program named MOBC has been used for criticality and isotopic evaluation of the core. The results of analysis showed that the use of burnable absorber rods for positive reactivity swing offset is necessary. In this regard the multiplication factor changes are limited in acceptable margin where the maximum reactivity swing is 655 pcm during a transient and 180 pcm during equilibrium state. On the other hand, although the power shape changes drastically in the earlier stage of core operation, it remains constant during the equilibrium state. In summary, by using the enriched uranium as a starter fuel the achievement of an equilibrium state is possible.
Performance Analysis of Multiple Access 60 GHz System Using Frequency-shifted Gaussian Pulse and Non-carrier PSWF Pulse

In this paper, a kind of impulse radio (IR) 60 GHz pulse based on Prolate Spheroidal Wave Functions (PSWF) is proposed. The capacity and performance for multiple access 60 GHz communication system based on carrier pulse and impulse radio pulse are analyzed separately. Both frequency-shifted Gaussian pulse and Prolate Spheroidal Wave Functions (PSWF) pulse are considered and devised according to the federal communication commission (FCC) power constraints. Pulse position modulation (PPM) with time hopping spread spectrum (THSS) is employed in the multiple access 60GHz communication system. The channel capacity and error probability for 60GHz communication system with different pulse waveforms over additive white Gaussian noise (AWGN) channel are compared and analyzed. The simulation results showed that the PSWF pulse 60GHz system with has better channel capacity and error probability performance than frequency-shifted Gaussian pulse 60GHz system.
Statistical approaches for analyzing immunologic data of repeated observations: A practical guide

Translational research not only encompasses transitioning from animal to human models but also must address the greater heterogeneity of humans when designing and analyzing experiments. Appropriate study designs can address heterogeneity through a priori data collection, and taking repeated measures can improve the power and efficiency of a study to detect clinically meaningful differences. Although common in other areas of biomedical research, modern statistical methods using repeated measurements on the same subject and accounting for their potential correlations are not widely utilized in immunologic studies. To highlight these analytic issues, we present a practical guide to understanding and applying analytic methods from commonly used T-tests without adjusting for multiple comparisons to mixed models with subject-specific adjustments for correlations using our data on Toll-like receptor-induced cytokine production in monocytes from young and older adults.
Branch holder

Die Erfindung betrifft eine Aststütze, insbesondere für Bäume, mit einem gabelartigen Auflager (2) für einen Ast, welches z.B. eine im Wesentlichen U- oder V-förmige Auflagefläche (3) aufweist, und mit einer Halterung (4) zur Anbringung des Auflagers (2) an einem Stützstab (5) in vorgegebener Höhe, wobei die Halterung (4) einen mit Mitteln zum werkzeugfreien Festlegen an dem Stützstab (5) ausgestalteten Seitenausleger (6) aufweist und das Auflager (2) sich an dem freien Ende des Seitenauslegers (6) befindet.