SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
The Talk about the City Culture and the Cultural Construction in Hengyang

City culture should be a kind of municipal culture which has a special and modern connotation.It has three levels: material culture,institutional culture and intellectual culture.In the cultural construction of Hengyang,Hengyang is orientated as city,ecological city,and city.To achieve the goal,we should work harder on the Three Creations and Promotions as follows:To create an livable city,continuously promote the material culture level in Hengyang city to let people enjoy the happiness of material culture life;to create an ecological city,constantly promote the taste of cultural life in Hengyang to make people have a more colorful cultural life and to create a harmonious city,ceaselessly promote the connotation of institutional culture in Hengyang city to have people's basic culture rights guaranteed better.This is the corporate responsibility for all people in Hengyang.
Infiltrating T cells promote prostate cancer metastasis via modulation of FGF11→miRNA-541→androgen receptor (AR)→MMP9 signaling

Early clinical studies suggested infiltrating T cells might be associated with poor outcomes in prostate cancer (PCa) patients. The detailed mechanisms how T cells contribute to PCa progression, however, remained unclear. Here, we found PCa cells have a better capacity to recruit more CD4(+) T cells than the surrounding normal prostate cells via secreting more chemokines-CXCL9. The consequences of more recruited CD4(+) T cells to PCa might then lead to enhance PCa cell invasion. Mechanism dissection revealed that infiltrating CD4(+) T cells might function through the modulation of FGF11→miRNA-541 signals to suppress PCa androgen receptor (AR) signals. The suppressed AR signals might then alter the MMP9 signals to promote the PCa cell invasion. Importantly, suppressed AR signals via AR-siRNA or anti-androgen Enzalutamide in PCa cells also enhanced the recruitment of T cells and the consequences of this positive feed back regulation could then enhance the PCa cell invasion. Targeting these newly identified signals via FGF11-siRNA, miRNA-541 inhibitor or MMP9 inhibitor all led to partially reverse the enhanced PCa cell invasion. Results from in vivo mouse models also confirmed the in vitro cell lines in co-culture studies. Together, these results concluded that infiltrating CD4(+) T cells could promote PCa metastasis via modulation of FGF11→miRNA-541→AR→MMP9 signaling. Targeting these newly identified signals may provide us a new potential therapeutic approach to better battle PCa metastasis.
Annegamenti

L’annegamento rimane un grave problema di sanità pubblica. La sua epidemiologia è meglio conosciuta grazie ai sondaggi estivi della Santé Publique France. L’analisi di queste indagini ci porta a considerare, per la Francia, l’annegamento come un fatto che presenta due facce principali. Quella dell’annegamento dei bambini piccoli, che si verifica maggiormente in acqua dolce e nelle piscine, e quella degli adulti maturi che avviene più in acqua di mare e nella banda dei 300 metri. La definizione di annegamento mette in evidenza il ruolo principale dell’insufficienza respiratoria acuta e dell’induzione dell’edema polmonare. La natura di questo edema polmonare deve essere meglio specificata perché senza dubbio non è esclusivamente lesionale. La gestione dell’annegamento comprende due aspetti complementari: un aspetto di primo soccorso e un aspetto medico. Il primo sottolinea l’importanza della rapida estrazione della vittima e il secondo l’importanza della gestione respiratoria. La prevenzione rimane il modo migliore di considerare il problema dell’annegamento. Pertanto, la prevenzione per i bambini deve concentrarsi sull’apprendimento del nuoto, sulla messa in sicurezza delle piscine e sull’attenzione dei genitori. Per quanto riguarda gli adolescenti e gli adulti, vanno sviluppate la riduzione dei comportamenti a rischio tra i più giovani e la riflessione sulla condizione fisica degli anziani. Infine, sono in corso di sviluppo degli studi sulla modellizzazione dei rischi di annegamento rispetto alle condizioni meteorologiche che potrebbero consentire di allertare i sistemi di emergenza nei periodi di maggior rischio.
Characteristic transport lengths (CTLs) in porous medium evaluated with classic diffusion solutions under infinite Biot number condition

Abstract In process engineering practice, including those in food industry, simple mathematical solutions are more useful. Learned assumptions are necessary to support effective simplifications. Previously it has been suggested that for a conduction and convection coupled system, there is an approximately linear temperature or concentration gradient between the surface and the average temperature, which occurs at a ‘fixed location’ within the conduction domain. The local temperature at the point is also said to be similar as the average temperature. This gradient is thus approximately the same as the temperature gradient at the interface between the conduction domain and the convection medium when thermal properties are considered constants. The distance from the surface to this ‘fixed location’ is marked as the characteristic transport length (CTL), which is a fraction of the size of the conduction medium. The previous findings were based on the agreements between the numerical solutions and compartmental, and then integral solutions in different occasions The argument has been validated among moderate Biot numbers (Bi) of 0.3. Similarly, one should find that the diffusional mass transfer process has the same property due to the same mathematical nature involved. Here, the mass diffusion process has been analyzed to yield the CTLs for the cases of infinite Biot number, where the analytical solutions for longer times for semi-infinite slab, infinite cylinder and sphere are available which can be put to great use. When applying these classical solutions for the above purpose, there are still new discoveries, which are interesting to report here.
Product Patent, the Problem of Availability of Patented Drugs and Parallel Trade: A Theoretical Approach

This article theoretically examines the potential effect of product patent on the availability of an essential drug in developing countries like India. Previous studies have indicated the possibility of a product patent making a drug unavailable in a developing nation. This has been shown under the uniform pricing policy adopted by the multinational company (MNC) that produces the drug. Allowing for price discrimination and comparing it with the above situation, we have argued that the problem of non-availability of a patented drug is, indeed, much less serious. However, successful price discrimination is not possible when markets are not perfectly segmented and “parallel trade” (a form of arbitrage) by the distributors exists. Our model incorporates such a possibility and establishes that even in the presence of parallel trade, the MNC can earn higher profits by supplying the drug to both the developed and the developing nations than by confining itself to the markets of developed countries.
Tourist enhancement of Venetian territories in the reclamation Consortium Bacchiglione Brenta

This project is designed for the tourist enhancement of the Consortium territories which belong to the province of Venice, and in particular the municipalities of Chioggia, Campagna Lupia, Campolongo Maggiore, Fosso, Vigonovo, Camponogara, Dolo and Stra. This territory, which possesses a valuable environmental and landscape heritage and is characterized by the reclamation construction work, bears witness to significant human activities. Hence this project, to direct tourist attention away from the most important and most visited centres (the beaches and the main urban centres) to these “lesser” sites which, if properly enhanced, can represent an interesting destination for visitors seeking personal fulfilment in the history and culture of a territory. The historical and cultural heritage is first rediscovered by safeguarding and making available online available historical records, which are then shared with the residents but also with potential tourists through the organization of public meetings and guided tours. The Consortium also promotes useful initiatives in order to enhance the knowledge of the territory outside the area. Project implementation should lead to the inclusion of the interested territory and the reclaimed sites in the main tourist circuits centring on the surrounding area. These sites can become an interesting alternative for tourists who crowd the most important places of the Venetian province and are interested in learning about the historical and cultural aspects of the visited territory.
Adaptation of the SDHC activity to the context of COVID-19

This project aims to support Simposium in adapting its office, methods of organisation of work and relationship with customers and suppliers, to the new conditions of the COVID-19 disease context, ensuring compliance with the established standards and recommendations of the competent authorities.
Sputter coated nanocrystalline ZnO for fabrication of thin film transistors

Fabrication of zinc oxide based thin-film transistors (ZnO-TFT), by RF magnetron sputtering at room temperature has been realized on thermally oxidized silicon wafer followed by the metal evaporation and lift-off process. The configuration of the TFT was bottom gate with the gold contacts on P-doped silicon. The device was observed to be a “normally on” device. Electrical characteristics, mainly, channel mobility, on/off ratio, and threshold voltage were extracted from the electrical characterization of TFT. The ZnO-TFT was found to operate with a threshold voltage of 12.075 V, channel mobility of 110.44 cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> /Vs, and an on/off ratio of approximately 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">5</sup> . Thickness of the ZnO film was confirmed by the UV spectrometer. No photo effect was observed, making it an ideal material for flat-panel displays. X-ray diffraction was performed to find out the orientation of the ZnO layer on the substrates. Preferred orientation was in the 002 plane. The high mobilities, ease of fabrication and cost-effectiveness make the ZnO-TFT a very desirable electronic device for futuristic flexible electronics.
Contract efficiency: demand uncertainty, price sensitivity and information asymmetry

Consider a supplier who is concerned with choosing a contract offered to the retailer. In addition to a wholesale price, the supplier looks for additional contract levers to improve performance. The three commonly used levers are inventory buyback, fixed payment and revenue sharing. This paper shows that the effectiveness of each of these contracts depends critically on the presence of three characteristics that define the complexity of the operating environment: demand uncertainty, demand price-sensitivity and information asymmetry. When the complexity is only about demand uncertainty, it is known that any of the three contracts can be utilised effectively by the supplier to extract all the first-best channel profit. When price-sensitivity of demand is added to the complexity, both revenue sharing and fixed payment remain perfectly effective. Inventory buyback, however, becomes a useless contract lever. We show that when the system is further complicated with information asymmetry, revenue sharing continues to be (almost) perfectly effective and inventory return stays to be useless. On the other hand, fixed payment proves to be useful, allowing the supplier to improve performance, but not to the degree of achieving first-best channel profit.
The Complete Genome Sequence of Bacillus safensis BRM1 Isolated from Brazilian Mangrove Sediment: A Potential Source of Biomass Converting Enzymes

Background: Bacillus safensis BRM1 was isolated from Brazilian mangrove sediment and selected for its ability to grow in xylan as the sole carbon source. To identify genes encoding biomass conversion enzymes, the genome of this bacterium was sequenced. Methods: Genome wide analysis revealed 99% nucleotide identity to the Bacillus safensis genome. The isolated strain was named B. safensis BRM1, and its genome consists of a circular chromosome of 3.74 Mb with a GC content of 41.8%. Genes encoding a plethora of hydrolytic enzymes are present in the BRM1 genome but absent from the other B. safensis genomes. Results: A total of 23 genes encoding putative cellulases or hemicellulases were identified. Conclusion: These data support that B. safensis BRM1 is an interesting candidate for the prospection of enzymes that can be applied in the conversion of cellulosic biomass to biofuel.
Education and Training of Referring Physicians Decreases At-Home Call Demand

Abstract Background Excessive, sometimes unnecessary consultation challenges the ophthalmology resident's ability to obtain adequate rest and personal time while taking at-home calls. Basic training of nonophthalmologists in assessing and treating common ophthalmic emergencies offers a potential solution to this problem by providing primary caregivers the knowledge base, tools, and confidence to manage them independently. Objective We measured ophthalmic consultation requests at a large teaching institution and the impact of an educational intervention on the number and type of requests. Methods During a 31-day period in 2009 all requests for urgent ophthalmic consultation were logged and characterized by reason, urgency, and source of the call. A 3-part educational intervention was targeted to residents and attending physicians in the departments of emergency medicine (half-day lecture and practice), anesthesiology (grand rounds lecture), and otolaryngology (guidelines for traumatic orbital fractures). Six months later we conducted a 26-day call log to evaluate the impact. Results Pre intervention, we received 63 total and 56 after-hours calls for urgent ophthalmic consultation as compared to 39 total and 35 after-hours calls post intervention. Ophthalmology residents reported seeing more urgent and fewer nonessential consultations in the postintervention period, and there was greater agreement between calling physicians' initial diagnosis and consulting physicians' final diagnosis. No adverse patient outcomes occurred as a result of the change in practices. Conclusion Basic education of nonophthalmologists in ophthalmic diagnostic and treatment concepts, through relatively brief educational interventions, was associated with a decrease in total consultation requests and more appropriate consultations in this pilot study at a single institution.
Robust features of the source process for the 2004 Parkfield, California, earthquake from strong-motion seismograms

SUMMARY We explore a recently developed procedure for kinematic inversion based on an elliptical subfault approximation. In this method, the slip is modelled by a small set of elliptical patches, each ellipse having a Gaussian distribution of slip. We invert near-field strong ground motion forthe2004September28Mw 6.0Parkfield,California,earthquake.Thedatasetconsistsof10 digital three-component 18-s long displacement seismograms. The best model gives a moment of 1.21 × 10 18 N m, with slip on two distinct ellipses, one with a high-slip amplitude of 0.91 m located 20 km northwest of the hypocentre. The average rupture speed of the rupture process is ∼2.7 kms −1 . We find no slip in the top 5 km. At this depth, a lineation of small aftershocks marks the transition from creeping above to locked below, in the interseismic period. The highslip patch coincides spatially with the hypocentre of the 1966 Mw6.0 Parkfield, California, earthquake. The larger earthquakes prior to the 2004 Parkfield earthquake and the aftershocks of the 2004 earthquake (Mw > 3) also lie around this high-slip patch, where our model images a sharp slip gradient. This observation suggests the presence of a permanent asperity that breaks during large earthquakes, and has important implications for the slip deficit observed on the Parkfield segment, which is necessary for reliable seismic hazard assessment.
Effects of Native Grass Cover Crops on Beneficial and Pest Invertebrates in Australian Vineyards

Indigenous cover crops have the potential to promote an increase in natural enemies providing fortuitous control of pest species and other ecosystem services. We test this idea in a vineyard in south eastern Australia, where reduced water availability because of drought coupled with increased temperatures has generated interest in sustainable alternatives to the exotic perennial cover crops commonly planted. Three endemic perennial cover crops, comprising the grasses Austrodanthonia richardsonii and Chloris truncata and a mix of two saltbushes (Atriplex semibaccata and Atriplex suberecta) were established as cover crops and compared with introduced oats (Avena sativa). Abundance of a range of predators and parasitoids was higher in vines with native cover crops compared with the oat control. In addition, predation levels of sentinel eggs of a common vineyard pest, light brown apple moth (Epiphyas postvittana), were increased in the native cover crops. However, the native cover crops also increased the abundance of some potential pest species. Native plants therefore have potential to increase abundance of beneficial invertebrates that assist in pest control, but need to be used carefully to ensure that they do not increase local pest problems.
Conect4Children (collaborative network for european clinical trials for children)

Paediatric medicines development is embedded in the European policy, legislation and in the work of the pharmaceutical industry but currently the potential of this effort is not realised. 
The conect4children (c4c) project will address the critical problems with the design, implementation and operational conduct of paediatric clinical trials, for example the fragmented and redundant efforts between sponsors, sites and countries.
This project will generate a sustainable infrastructure that optimises the delivery of clinical trials in children through: a) a single point of contact for all sponsors, sites and investigators; b) efficient implementation of trials adopting consistent approaches, aligned quality standards and coordination of sites at national and international level; c) collaboration with specialist networks; d) high quality input to study design and preparation through rigorous strategic and operational feasibility assessment and e) the promotion of innovative methodologies. 
The project will be managed according to IMI2 best practice with a dedicated communications effort. The clinical trials infrastructure will be setup, implemented and tested by implementing 3-4 industry and at least 1 non-industry proof-of-viability studies. Expert advice groups will promote innovative methodologies and engagement with regulators. The business model for a sustainable infrastructure will be based on the European landscape of paediatric networks and available trial sites, the evaluation of services needs of sponsors of all kinds, and will be informed by the proof-of-viability studies. Supporting activities will include: data management (data about the trials and the network, including performance metrics for network management and promotion; handling trial data for non-industry sponsors; support for common data dictionaries); education and training. 
The voices of children, young people and their families will be central to the network.
Law and Society in Ostrogothic Italy: Evidence from the Edictum Theoderici

1Long after Rome’s collapse in 476, Roman law continued to function as a source of prestige and power in some of the barbarian kingdoms that emerged in the former provinces of the western empire. More than just a symbol of a distant and bygone culture, Roman law served as an important medium through which authority could be articulated by the barbarian kings who replaced imperial authorities in the west. This study proposes to investigate how Roman law survived and evolved in Italy to refl ect the profound social, political, and economic changes that occurred from the fourth through the sixth centuries. Evidence is drawn primarily from the Edictum Theoderici, a brief collection and emendation of Roman law drawn up in the tradition of the Praetor’s Edict by Roman jurisprudents working under the auspices of the Ostrogothic king Theoderic the Great (493–526). The little-studied Edictum yields valuable historical insights into Italy’s transition from Roman province to barbarian kingdom. It also raises important questions as to just how peaceful, prosperous, and Roman-like Theoderic’s kingdom really was. In the autumn and winter of 488/9, after concluding a formal treaty with the emperor Zeno (474–491), Theoderic the Amal set out from Thrace with his followers to create a Gothic kingdom in the rich and famous lands of Italy. Standing in his way was Odovacar (476–493), a general of Germanic extraction who had usurped power in the peninsula following his removal of Romulus “Augustulus” in 476. 2 During four years of campaigning, Theod
The gravity model, African Growth and Opportunity Act (AGOA) and US trade relations with sub-Saharan Africa

The United States of America enacted the African Growth and Opportunity Act (AGOA) in 2000 to grant sub-Saharan African countries (SSA) a preferential treatment in their exports to the USA. With this Act, most of the exports from SSA can now enter the USA duty-free, and this is expected to boost the exporting and manufacturing sectors in SSA. Hopefully, this singular act of assistance from the USA will spur entrepreneurship in SSA, thereby creating jobs and jump starting meaningful economic growth in the region. Since trade is a major catalyst in economic development, AGOA is arguably the most meaningful intervention from a developed country to an under-developed region such as SSA in recent times. Has AGOA had any impact on US trade with SSA? This paper sheds some light on this issue by examining the flow and composition of trade between the USA and AGOA countries. The analysis uses trade data (US imports) for 36 countries over 12 years. Empirical estimations based on the gravity model show that receivin...
Hoja de ruta de digitalización de Kitman Thulema

El objetivo del proyecto es identificar las principales necesidades en el ámbito de la digitalización y elaborar una visión y un plan de acción para el desarrollo digital de la empresa. Se analizará el flujo de datos en los principales procesos de la cadena de valor y los vínculos entre los procesos y las aplicaciones informáticas. La ejecución de los proyectos de mejora previstos en el Plan de Acción de Ictalización tiene por objeto aumentar la eficiencia de los procesos y mejorar la calidad de los datos. Esto, a su vez, aumenta la creación de valor añadido y aumenta la ventaja competitiva.