SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Sex-Specific Mortality Risk by QRS Morphology and Duration in Patients Receiving CRT

Prior studies have suggested that women have better outcomes than men after cardiac resynchronization therapy-defibrillator (CRT-D) implantation. The purpose of this study was to compare mortality after CRT-D implantation by sex, QRS morphology, and duration. Survival curves and covariate adjusted hazard ratios (HR) were used to assess mortality by sex in 31,892 CRT-D patients in the National Cardiovascular Data Registry (NCDR), implantable cardioverter defibrillator (ICD) registry between 2006 and 2009, with up to 5 years’ follow-up (median 2.9 years, interquartile range: 2.0 to 3.9 years). Patients were grouped by QRS morphology and 10-ms increments in QRS duration. Among patients with left bundle branch block (LBBB), women had a 21% lower mortality risk than men (HR: 0.79; 95% CI: 0.74 to 0.84; p < 0.001); however, there was no sex difference in non-LBBB (HR: 0.95; 95% CI: 0.85 to 1.06; p = 0.37). Longer QRS duration was associated with better survival in both sexes with LBBB, but not in patients without LBBB. Compared with women with LBBB and QRS of 120 to 129 ms, women with LBBB and QRS of 140 to 149 ms had a 27% lower mortality (HR: 0.73; 95% CI: 0.60 to 0.88; p = 0.001); this difference was 18% in men (HR: 0.82; 95% CI: 0.71 to 0.93; p = 0.003). Mortality in LBBB and QRS of 150 ms or longer compared with those with LBBB and QRS of 120 to 129 ms was similar between sexes (HR: 0.61 to 0.68; p < 0.001 for women and HR: 0.58 to 0.66; p < 0.001 for men). Sex interactions within 10-ms groups were not significant. Among patients with LBBB who received CRT-D, mortality is lower in women than men. Additionally, longer QRS duration in LBBB is associated with better survival in both sexes. In contrast, there is no sex difference in patients without LBBB, regardless of QRS duration. Further studies should include a non-CRT comparator group to confirm these findings.
Lupus and autoimmune shock: Use of intravenous gammaglobulin. Case report and proposal for a new designation

Shock is a state of hypotension and hypoperfusion which in turn leads to cellular dysfunction, neuroendocrine responses, inflammatory mediator release, and alterations of the microcirculation. There are various ways of classifying tissue perfusion failure. A simple method is dividing them into a distributive category, such as septic or anaphylactic shock, and a non-distributive category such as hypovolemic shock. There is extensive knowledge on septic shock; the interaction between bacteria and the antigen presenting cell receptor (TRL-2, TRL-4) releases a proinflammatory cytokine storm, favoring the production of nitric oxide, thus perpetuating the hypotensive state. The imbalance between proinflammatory and anti-inflammatory cytokines creates an immunologic dysfunction, which favors the systemic inflammatory response syndrome and unleashes a shock state, a situation named immunologic dissonance by Dr. Roger Bone in 1996. From our perspective, this term explains the alterations presented in one particular case, where the cornerstone is the dysfunction of the patient’s immune system and its culmination in a distributive form of shock, which from our hypothetical perspective is of autoimmune origin. We consider autoimmunity to be the platform leading to the state of immunologic dissonance responsible for autoimmune shock, which we believe merits a non-traditional approach. For this reason in a case in which we suspect shock based on autoimmunity, intravenous gammaglobulin was used in conjunction with a bolus of methylprednisolone in an attempt to counteract the immunologic dissonance; satisfactory results were obtained.
METHODS OF INCREASING RESISTANCE OF CROP PLANTS TO HEAT STRESS AND SELECTING CROP PLANTS WITH INCREASED RESISTANCE TO HEAT STRESS

Methods of increasing the resistance of a crop plant to heat stress and in particular methods of improving the grain yield and quality of crop plants grown under heat stress in the form of increased minimal temperatares are provided. The methods include selecting plants with increased expression of HYR and growing these plants in regions expected to experience minimal temperatures above 25°C during the growing season. Methods of screening plants for increased resistance to heat stress and methods of producing grain in regions having minimal temperatures of 25°C or more are also provided.
Genesis of Streamwise-Localized Solutions from Globally Periodic Traveling Waves in Pipe Flow

The aim in the dynamical systems approach to transitional turbulence is to construct a scaffold in phase space for the dynamics using simple invariant sets (exact solutions) and their stable and unstable manifolds. In large (realistic) domains where turbulence can co-exist with laminar flow, this requires identifying exact localized solutions. In wall-bounded shear flows the first of these has recently been found in pipe flow, but questions remain as to how they are connected to the many known streamwise-periodic solutions. Here we demonstrate the origin of the first localized solution in a modulational symmetry-breaking Hopf bifurcation from a known global travelling wave that has 2-fold rotational symmetry about the pipe axis. Similar behaviour is found for a global wave of 3-fold rotational symmetry, this time leading to two localized relative periodic orbits. The clear implication is that all global solutions should be expected to lead to more realistic localised counterparts through such bifurcations, which provides a constructive route for their generation.
Improving policy instruments to increase the energy efficiency in industrial SMEs

The project´s core challenge is to increase energy efficiency in SMEs. The European Parliament set a binding target of increasing, by a minimum of 35%, the energy efficiency by 2030 compared to the 2005 level, in all Member States. Therefore, the project partners are sharing their good practices to find the best solutions to contribute to the achievement of the target set. Engaging in discussions and exchanging experiences with relevant actors is the best way to find solutions to increase the involvement of the industrial SMEs in energy efficiency improvement. Common barriers to overcome in the regions are the:

- the low interest of industrial SMEs participating in energy efficiency policy programmes,
- the low number of industrial SME energy efficiency policy programmes.

Therefore the project partner will a) improve the energy policies by exchanging and comparing the regional policy instruments in the eight regions, b) jointly develop regional policy action plans supporting the implementation of energy efficiency programmes and thus utilize the potential in the industrial SME sector c) exchange information and experience and by this help the stakeholders supporting the regional action plans set to overcome the barriers.

Therefore, our actions will:

- increase the interest of industrial SMEs in participating in the energy efficiency policy programmes,
- support starting-up effective industrial SME´ energy efficiency policy programmes,
- help integrate energy-related policy measures from other sectors in the industrial SME sector.

The exchange of experience, workshops and study visits with the stakeholders will help us achieve the project´s objectives. The jointly developed regional action plans will also influence the policies for the next Regional Operational Programme period 2021-2027.
Association between<i>Serine/Threonine Kinase 39</i>Gene Polymorphism, Hypertension, and Other Cardiovascular Risk Factors in Koreans

Although the association between single nucleotide polymorphisms (SNPs) of Serine/Threonine Kinase 39 (STK39) and hypertension has been reported, the prior studies have been inconsistent. The aim of this study is to evaluate the association between rs3754777 and rs6749447, the two SNPs of STK39, and hypertension and other cardiovascular risk factors in Koreans, residing in the Republic of Korea.We included 238 hypertensive patients and 260 controls. The associations between genotype and haplotype combination and hypertension were examined. In addition, possible SNP-related differences in the adjusted blood pressure and other cardiovascular risk factors were analyzed.There was no significant association between the two SNPs and hypertension. However, the carriers of AA genotype of rs3754777 showed lower blood glucose and cholesterol levels, particularly in females. Genotype of rs6749447 was associated with the waist circumference, triglyceride, and high density lipoprotein-cholesterol levels, only in gender-stratified analysis. The effects of haplotype combinations on risk factors were compatible with genotype effects of each SNP.Associations between the two SNPs of STK39, rs3754777 and rs6749447, and hypertension were not significant. However, the two SNPs showed genotype-related differences in blood glucose, lipids, and waist circumference, especially in women. Further studies are needed to clarify the effect of STK39 variants in these cardiovascular risk factors.
MAGNETICALLY-ACTUATED LATCH MECHANISM FOR DISPLAY MODULE

A display module comprises a support, a plurality of light-emitting elements coupled to the support and a latch mechanism (150) to removeably couple the support to a chassis (154). The latch mechanism includes a movable member (156), a latch member (168), and a linkage mechanism (166). The movable member is moved from a first position to a second position when magnetically engaged by a tool magnet. The latch member moves between a first latch member position and a second latch member position and can engage a chassis mating structure when in the first latch member position. The linkage mechanism mechanically connects the movable member to the latch member so that they move together such that the latch member is in the first latch member position when the movable member is in the first position and is in the second latch member position when the movable member is in the second position.
Smart cultural tourism as a driver of sustainable development of european regions

SmartCulTour aims to support regional development in European regions, with special attention to rural peripheries and the urban fringe, through sustainable cultural tourism. The project redefines cultural tourism through a contemporary lens and provides a comprehensive measurement framework for supply, demand and impacts. In order to support knowledge-led destination management, a decision-support system (DSS) will be developed for wide-scale monitoring purposes across European regions. The DSS will synthesize both traditional and non-traditional data sources, the latter particularly related to big data analytics, thereby assisting smart regional development. Besides a contribution to conceptual development and cultural tourism measurement, the main objective of SmartCulTour relates to the facilitation of community-led rural development through field experimentation in 6 living labs. Prior to these living labs, a comprehensive desk research will identify significant sustainable cultural tourism policies, their impacts and critical success factors. These best cases will inspire a series of possible local interventions. Within the living labs, novel creative approaches to stakeholder engagement are tested, notably arts-based methods, serious games, and service design which will help to provide local context and support. A toolkit will be designed to help destinations implement local actions towards sustainable cultural tourism development. SmartCulTour will therefore contribute to theory development, empirical validation of best practices within a living labs setting, and procedural development, particularly by providing European regions with a set of strategies to optimally engage with stakeholders and co-create sustainable cultural tourism experiences.
Improved biodiversity for a waste-free exploitation of traditional crops

This project aims to promote the creation of a thematic tourist route in the program area based on the exploitation of biodiversity, environmental and cultural resources, and on the concept that waste must not be produced. Flax, hemp and nettles, are traditional regional crops and a perfect example of a “No Waste Lifecycle”, since they grow very rapidly, also on marginal land, without requiring pesticides, and all of their components are basic commodities: fibers for paper, textiles or composites; seeds for traditional foods and high quality oils; extracts for cosmetics. They are therefore an ideal tool for the creation of a “thematic route” that winds through our region and introduces visitors to the “NO WASTE” concept, with concrete examples and tangible products. The aim of this project is to promote a common understanding between active parties, through workshops and meetings, to identify the key features of this thematic route, that links knowledge, inquiry, and action. It would promote commercialization of the products while stimulating visitors to consider a healthier and more sustainable future. An additional key aspect of the project will be the dissemination of these principles among students, with demonstrations and experiments in cooperation with schools.
La trayectoria vital de los actores del siglo XVIII: Un componente de la historia teatral por explorar

Los datos sobre la vida y la actividad de los actores, vistos como seres individuales y no como grupo, son numerosos pero muy dispersos. Recopilarlos gracias a herramientas modernas como MOVACT parece indispensable hoy en día: a través del prisma de la trayectoria vital de los actores, su movilidad por la Península, las compañías de las que formaron parte y las obras en las que actuaron, no solamente podremos conocerlos mejor, sino que afinaremos nuestro conocimiento de la actividad teatral en España en la segunda mitad del siglo XVIII y podremos abrir nuevas perspectivas de investigación.
Lumbar spine radiographic features and demographic, clinical, and radiographic knee, hip, and hand osteoarthritis

To determine the prevalence of lumbar spine individual radiographic features (IRFs) of disc space narrowing (DSN), osteophytes (OST), and facet joint osteoarthritis (FOA); to describe the frequencies of demographic, clinical, and radiographic knee, hip, and hand osteoarthritis (OA) across lumbar spine IRFs; and to determine factors associated with lumbar spine IRFs.We conducted a cross-sectional study of 840 participants enrolled in the Johnston County Osteoarthritis Project (2003-2004). Sample-based prevalence estimates were generated for each lumbar spine IRF. The associations between lumbar spine IRFs and demographic, clinical, and peripheral joint OA were determined with logistic regression models.Sample-based prevalence estimates were similar for DSN (57.6%) and FOA (57.9%) but higher for OST (88.1%), with significant differences across race and sex. Hand and knee OA frequencies increased across IRFs, whereas the effect was absent for hip OA. African Americans had lower odds of FOA (adjusted odds ratio [OR(adj) ] 0.45 [95% confidence interval (95% CI) 0.32-0.62]), while there was no racial association with DSN and OST. Low back symptoms were associated with DSN (OR(adj) 1.37 [95% CI 1.04-1.80]) but not OST or FOA. Knee OA was associated with OST (OR(adj) 1.62 [95% CI 1.16-2.27]) and FOA (OR(adj) 1.69 [95% CI 1.15-2.49]) but not DSN. Hand OA was associated with FOA (OR(adj) 1.67 [95% CI 1.20-2.28]) but not with DSN or OST. No associations were found with hip OA.These findings underscore the importance of analyzing lumbar spine IRFs separately as the associations with demographic, clinical, and radiographic knee, hip, and hand OA differ widely.
Banking for the public good

Bank shareholders cannot be expected to provide good stewardship to banks because there is a conflict of interests between the shareholder owners and a non-mutually owned bank's depositors; who provide the bulk of the funds in traditional retail banks and are willing to accept a lower return on their savings than shareholders, in return for lower risk exposure. Regulation is required to protect depositors where deposit insurance schemes are at best partially funded and underwritten by taxpayers, who in turn need to be protected, and to deliver financial stability, a public good. Once some banks become ‘too big (to be allowed) to fail’ (TBTF), they enjoy additional implicit public (taxpayer) insurance that enables them to fund themselves more cheaply than smaller banks, which gives them a competitive advantage. The political influence of big banks in the US and the UK is such that they can be regarded as financial oligarchies that have hitherto successfully blocked far reaching structural reform in the wake of the ‘Global Financial Crisis’ and lobbied successfully for the financial sector liberalisation that preceded it. The TBTF problem and associated moral hazard have been worsened by mergers to save failing banks during the crisis and as a result competition within a number of national banking systems, notably the UK, has been significantly reduced. Solutions alternative to making the banks small enough to be allowed to fail are considered in this paper, but it is difficult to be convinced that they will deliver banks that promote the common or public good. It is argued that regulating retail banking as a utility and pooling insurance against financial instability using pre-funded deposit insurance schemes, with risk related premiums that can also serve as bank resolution funds, should be pursued; and that capital leverage ratios and/or Financial Activity Taxes might be used to ‘tax’ the size of banks.
Fabrication of Three Different Types of Porous Carbonate-Substituted Apatite Ceramics for Artificial Bone

The purposes of this study were to fabricate porous carbonate-substituted apatite (CAp) ceramics and characterize important properties such as compressive strengths and dissolution rates for an artificial bone. Porous A-type CAp (A-CAp) with uniaxial pores was fabricated by sintering porous hydroxyapatite green bodies at 1000°C in carbon dioxide gas atmosphere. B-type CAp (B-CAp) nanocrystals prepared by a wet method were mixed with an organic binder, freeze-dried and heated at 800°C in air, and AB-type CAp (AB-CAp) was fabricated by heating B-CAp porous bodies including the organic binder at 1100°C in carbon dioxide gas atmosphere. From the morphological observations with a scanning electron microscope, the porous A-CAp had uniaxially oriented pores of 104±33 μm in diameter, while the porous B-CAp and AB-CAp had large pores of 143±48 μm and 181±46 μm in diameter, of which pores were interconnected with small pores of 31±11 μm and 45±17 μm in diameter. The dissolution rates of CAps were apparently larger than that of HAp; the calcium concentrations increased in the order of AB-CAp &gt; B-CAp &gt; A-CAp &gt; HAp. This is mainly attributed to carbonate content although it could be partialy depended on the different porous structures and diameters.
The Impact of Capital Market and Economic Growth in Nigeria.

The Nigerian capital market has witnessed obvious transformation over the years, evident by the increased level of participation of the private and public investors at the floor of the stock exchange and in various public offers of quoted companies. The emerging market has also attracted and embraced the attention and the interest of international investors, thus increasing capital inflow. The overall market capitalisation had risen from 1,698.1 million naira in 1980 to 7030.8 billion naira in 2009, thus signifying an increase within the period. Transaction at the floor of NSE has risen to a total of 685716.2 million naira in 2009 from a previous value of 16.6m recorded in 1970. From the result obtained, capital market has positive and significant impact on economic growth in Nigeria. The capital market variables captured in the model such as market capitalization, number of deals and value of transactions were all positive and significant in promoting economic growth in Nigeria. It is important that the government should implement policies that will make the market more efficient and re-position it for growth within the Nigerian economy. Keywords: Capital Market, Economic Growth, Stock Exchange, Market Capitalisation.
Parallel multiple observer siting on terrain

This paper presents the optimization and parallelization of the multiple observer siting program, originally developed by Franklin and Vogt. Siting is a compute-intensive application with a large amount of inherent parallelism. The advantage of parallelization is not only a faster program but also the ability to solve bigger problems. We have parallelized the program using two different techniques: OpenMP, using multi-core CPUs, and CUDA, using a general purpose graphics processing unit (GPGPU). Experiment results show that both techniques are very effective. Using the OpenMP program, we are able to site tens of thousands of observers on a 16385 × 16385 terrain in less than 2 minutes, on our workstation with two CPUs and one GPU. The CUDA program achieves the same in about 30 seconds.
“Animal-Free testing for acute toxicity”

XCellR8 Limited aims to offer the first completely animal-free test for human acute toxicity. The primary focus is cosmetic product safety but the test may also later be applied to other industry sectors including household products, agrochemicals, medical devices and pharmaceuticals. In this context, animal-free means in vitro human cell culture based methods that do not utilise any animal-derived components. There are currently no validated in vitro tests for acute toxicity. Previous attempts to develop such tests used mouse cells and animal-derived components in the culture system and therefore still ultimately required the sacrifice of animals – an approach that is not considered acceptable by ethical cosmetic companies or by the public. The technological feasibility of the project has already been established, through existing tests of XCellR8’s internally developed proprietary methods.  This feasibility assessment project is primarily required to address other practical, commercial, regulatory and financial aspects. It will also expand existing market research to assess the appetite of a greater cross-section of industry for such tests. During the project XCellR8 will investigate the alternative routes for test development and adoption by industry as a non-regulatory test to support product development. The ultimate objective is the international validation of the test and regulatory acceptance via incorporation into OECD Guidelines. The proposed project constitutes scientific advancement, using a fully human based method to assess human safety, as well as providing ethical, financial and commercial advantages over the use of animal tests. This offers true SME business model innovation, with an SME creating a pioneering solution that could bring a fundamental change to the manner in which cosmetic companies (and their suppliers) validate the safety of the ingredients used in their products.