SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Declined Guideline Adherence in Older Breast Cancer Patients: A Population-Based Study in The Netherlands

Older women with primary operable breast cancer might receive suboptimal care due to their advanced age. Although several studies reported age as an independent determinant for receiving none or less treatment according to accepted standards, prospective data are lacking. This study evaluates the adherence to a consensus protocol in unselected women aged 80 years and older in the Netherlands. Data were derived from the Dutch population-based Cancer Registry held by the Comprehensive Cancer Centre East. In this study all female patients, 60 years and older, diagnosed with breast cancer TNM stage I-IIIa in the period 2001 until 2006 were selected. Applied treatment according to the Dutch guideline was compared for different age groups. Differences between age groups were evaluated using a chi-square test. In total, 2336 breast cancer patients were studied. Treatment adherence was significantly lower for surgery, radiation therapy and systemic therapy in women aged 80 years and older, and all modalities were applied much less frequently, except for endocrine therapy which was more frequently applied in the oldest old. This study shows a sharp decline in guideline adherence for unselected women aged 80 years and older with primary operable breast cancer, with an observed shift from appropriate locoregional treatment toward endocrine therapy. Whether this approach is justified or not should preferably be tested prospectively.
METHOD FOR OPERATING A DRYER AT VARIABLE SPEED OF A DRIVE MOTOR AND DRYER SUITABLE THEREFOR

The invention relates to a method for operating a dryer (1) comprising a program control unit (8), a drum (3) for pieces of laundry to be dried, a process air duct (2) in which a process air blower (6) for conveying the process air and a heating unit (4) for heating the process air are located, and a variable-speed motor (13) which drives the drum (3) and the process air blower (6). The method comprises a heat-up phase, a semi-stationary drying phase and a cool-down phase, the variable-speed drive motor (13) being operated at an average speed alpha1 and the process air blower (6) being operated at an average speed omega1 during the semi-stationary drying phase, and the drive motor (13) being operated at a speed alpha2 which is smaller than alpha1 and the process air blower (6) being operated at a speed omega2 which is smaller than omega1 at least intermittently during the cool-down phase. The invention further relates to a dryer suitable for performing said method.
APPARATUS FOR MAINTAINING FLUID TEMPERATURE

An apparatus for maintaining water temperature comprised of an inlet, a mechanical temperature controlled shutoff valve, a check valve and an outlet. The shutoff valve and check valve are positioned between the inlet and outlet to provide for the shunting of water from the inlet to the outlet based upon the temperature of the water, thereby maintaining water temperature at the inlet. This permits continuous access to hot water at a faucet which has the apparatus installed between its inlets. The apparatus may be configured as a temperature control assembly and attached in line with a hot water supply system thereby maintaining the hot water temperature within the hot water supply side of the system. Tees may be attached to the to the inlet and outlet of the apparatus as well as the hot water inlet and cold water inlet of a faucet, thereby creating a temperature controlled faucet.
Postoperative ischemic changes following brain metastasis resection as measured by diffusion-weighted magnetic resonance imaging

Object Brain metastases occur in 10% to 40% of patients harboring cancer. In cases of neurosurgical metastasis resection, all postoperative neurological deterioration should be avoided. Reasons for postoperative deficits can be direct tissue damage due to resection, hemorrhage, venous congestive infarcts, or arterial ischemic events leading to tissue infarction. The aim of this study was to evaluate whether postoperative ischemic infarctions occur in surgery for brain metastasis and to determine their influence on new postoperative neurological deficits. Methods Patients who underwent resection of brain metastases and had preoperative and early postoperative (within 48 hours) MRI scans, including diffusion-weighted imaging sequences and apparent diffusion coefficient maps, between January 2009 and May 2012 were included in this study. Clinical and histopathological data (histopathological results, pre- and postoperative neurological status, and previous tumor-specific therapy) were recorded. Results One hundred twenty-two patients (56 male, 66 female) who underwent resection of brain metastases were included. The patients' mean age was 60 years (range 21–89 years). The mean time span from initial tumor diagnosis to resection of brain metastasis was 44 months (range 0–338 months). The mean preoperative Karnofsky Performance Status was 80% (exact mean 76% ± 17% [SD]), and the mean postoperative value was 80% (exact mean 78% ± 17%). Twelve (9.8%) of the 122 patients had postoperative permanent worsening of a neurological deficit or a new permanent neurological deficit; 44 (36.1%) of the 122 patients had postoperative ischemic lesions. When comparing patients with and without previous brain irradiation, 53.8% of patients with previous brain irradiation had ischemic lesions on postoperative imaging compared with 31.3% of patients without previous brain irradiation (p = 0.033). There was a significant association between ischemia and postoperative neurological status deterioration (transient or permanent); 13 (29.5%) of 44 patients with ischemic lesions had deterioration of their neurological status compared with 7 (9%) of the 78 patients who did not have ischemic lesions (p = 0.003). Conclusions This study demonstrates a high prevalence of vascular incidents in patients undergoing resection for metastatic brain disease. Patients harboring postoperative ischemic lesions detected by MRI have a higher rate of neurological deficits (transient or permanent). Patients who had previous irradiation therapy are at higher risk of developing postoperative ischemic lesions. A large number of postoperative neurological deficits are caused by ischemic incidents.
Structuring of material parameters in lithium niobate crystals with low-mass, high-energy ion radiation

Ferroelectric lithium niobate crystals offer a great potential for applications in modern optics. To provide powerful optical components, tailoring of key material parameters, especially of the refractive index n and the ferroelectric domain landscape, is required. Irradiation of lithium niobate crystals with accelerated ions causes strong structured modifications in the material. The effects induced by low-mass, high-energy ions (such as 3He with 41 MeV, which are not implanted, but transmit through the entire crystal volume) are reviewed. Irradiation yields large changes of the refractive index Δn, improved domain engineering capability within the material along the ion track, and waveguiding structures. The periodic modification of Δn as well as the formation of periodically poled lithium niobate (PPLN) (supported by radiation damage) is described. Two-step knock-on displacement processes, 3He→Nb and 3He→O causing thermal spikes, are identified as origin for the material modifications.
ISB News September 2011: from the President and Secretary

We are pleased to announce the Phenology 2012 Conference. This second interdisciplinary international conference will be held at the University of WisconsinMilwaukee, 10–13 September 2012. This conference aims to bring together experts from around the world in all sub-fields of phenology and related disciplines. The overall theme of the conference is Future Climate and the Living Earth. Conference products will include a set of peer-reviewed scientific papers in a special issue of the International Journal of Biometeorology. The conference will run over 4 days, starting on Monday 10 September 2012, and finishing on Thursday 13 September 2012. Main events will take place at the UWMilwaukee School of Continuing Education Conference Center located in the heart of Milwaukee's business and commercial district. The conference dinner will be held in the Pilot House at Discovery World and include access to the Reiman Aquarium. Keynote speakers will be Dr. Thomas R. Karl, Director of the USA National Climatic Data Center, and Regents Professor Steven W. Running, University of Montana. Field trips will be held on the last day of the conference and are under development. Please visit the conference website: to see more information and to register your interest in order to be included in future direct messages. The Chair of the Phenology 2012 Conference is Distinguished Professor Mark D. Schwartz, who is also Chair of the ISB Phenology Commission and Chair of the USA National Phenology Network Board of Directors. He hopes to see many of you in Milwaukee in September 2012!
The enforceability of time bar clauses in construction contracts : a comparative analysis between the Egyptian civil code and the English and Welsh common law jurisdictions

Construction claims are a fact of life on all projects across the world. In an attempt to safeguard themselves against the risk of claims, employers utilise time bar clauses in construction contracts to waive the contractor’s entitlement to any additional costs or time if a notice of claim is not served by the contractor within a specific period of time. The reality of whether such a time bar is enforceable depends on the law governing the contract. Therefore, it is incumbent upon professionals contracting across different regions of the world and using standard form construction contracts that were prepared under a different jurisdictional setting than their own to be aware and acquainted with the extent to which these time bar clauses are enforceable under the law governing the contract in question. This research provides an in-depth insight regarding the enforceability of time bar clauses in English law and the Civil Code jurisdiction of Egypt, using the time bar in sub-clause 20.1 of the FIDIC 1999 Red Book as the basis for comparison. The results of this research do not solely apply to the time bar clause in the FIDIC 1999 Red Book, but also to any time bar clause in a bespoke form of contract that acts as a condition precedent. The need for this research and its uniqueness stem from the fact that it aims to fill a critical gap in the construction law literature as, while there is an abundance of literature on the enforceability of time bar clauses under English law, there is scarcely any sizeable research dedicated to the same topic under the Egyptian Civil Code. The research utilises a comparative law methodology to compare the enforceability of the FIDIC time bar across the two jurisdictions utilising three key concepts as the basis for comparison, namely statutory limitation, good faith and the prevention principle. As part of this methodology, the research takes a step beyond the subject of the research and delves into the historical origin of the similarities and differences highlighted. In doing so, the research concludes with two key premises for the causes of the similarities and differences highlighted in the research, namely the principle of freedom of contract under English law and the effect of the French Civil Code on the formation of the Egyptian Civil Code. This, in turn, results in historical elaborations of both premises.
La pandemia de covid-19 y las mipymes saltoguaireñas del Paraguay

Este artículo analiza el impacto de la pandemia del COVID-19 en los negocios de las micro, pequenas y medianas empresas de la ciudad de Salto del Guairá en Paraguay. La metodología utilizada fue la aplicación de un cuestionario estructurado a un grupo de emprendedores, según una muestra estadística. La encuesta se realizó en el segundo semestre de 2021. Los resultados mostraron que incluso antes de la pandemia, las micro y pequeñas empresas de Salto del Guairá ya estaban sufriendo los impactos de la crisis económica en Brasil. Luego, la pandemia profundizó la crisis económica en la frontera Paraguay-Brasil. La asimetría de información sobre la legislación y los beneficios otorgados por el gobierno paraguayo dificultó la gestión y mantenimiento de las empresas.
Mimicking Nature, or At Least Trying To

It's fairly well known that the inspiration for Velcro came from cockleburs caught in the hair of George de Mestral's dog, and that Leonardo da Vinci drew on the bird's wing for ideas for his flying machines. It seems that humans have been attempting to copy nature for a very long time, and this impulse continues today, though much of the observation and experimentation is now done at the microscopic and molecular levels. If anything, nature's ingenuity is even more in evidence there. For example, tree frogs have hexagonal cells on their toe pads that are surrounded by mucus-filled channels. The cricket Tettigonia has smooth adhesive pads with a hexagonal pattern of grooves. In each case, the combination of form and material makes for very effective adhesion. Researchers have found that the channels and grooves greatly augment adhesion when combined with the hexagonal pattern of surfaces (Barnes, 2007).

Geckos' feet, too, have gotten a lot of attention in the last few years as a source of insights into how to create an adhesive that is strong, reversible, and reusable. This is a tall order, but geckos obviously have a good solution to the problem because they easily walk, even run, across ceilings. Analysis of their foot pads revealed foot hairs called ‘‘setae’’ that are made of keratin and subdivided into spatulae, creating a large surface area for adhesion (Lee et al., 2007). Humans have devised substances that mimic this ability, but there are two problems. First, the substances weaken with reuse, and second, they don't work well when wet.

To deal with these issues, researchers have looked to another organism noted for its bonding powers, the mussel, which has powerful adhesive proteins in its holdfast. A synthetic polymer with similar properties was coated onto a surface with nano-scale pillars …
Maternal–infant biomarkers of prenatal exposure to arsenic and manganese

Because arsenic (As) and manganese (Mn) are able to pass the placenta, infants among exposed populations may be exposed to considerable levels in utero. The main objective of this paper is to evaluate infant toenails, hair, and cord blood as biomarkers of prenatal exposure to As and Mn and determine the relationship between maternal and infant As and Mn concentrations in these biomarkers. Of the 1196 pregnant women in Bangladesh who were monitored throughout pregnancy until 1 month post-partum and completed all study visits, we included 711 mother-infant pairs who had at least one maternal and one infant biomarker of exposure available for analysis. Toenail and hair samples were collected from the women during the first trimester and 1 month post-partum and from the infants at the age of 1 month. Cord blood was collected at the time of delivery. Maternal toenail concentrations were correlated with infant toenail concentrations for As and Mn (n=258, r=0.52, 95% CI: 0.43-0.60, P<0.0001 and r=0.39, 95% CI: 0.28-0.49, P<0.0001), respectively. Similarly, maternal hair concentrations were correlated with infant hair As (n=685, r=0.61, 95% CI: 0.56-0.65, P<0.0001) and infant hair Mn (n=686, r=0.21, 95% CI: 0.14-0.28, P<0.0001). Cord blood As was correlated with infant toenail and hair As, although cord blood Mn was only correlated with infant toenail. Toenails and cord blood appear to be valid biomarkers of maternal-fetal transfer of As and Mn, whereas hair may not be a suitable biomarker for in utero exposure to Mn.
100K+ words, machine-readable, pronunciation dictionary for the Romanian language

This paper intends to present a newly developed Romanian language pronunciation dictionary called NaviRo. The dictionary contains more than 100k words from the DexOnline dictionary together with their phonetic transcriptions in Speech Assessment Method Phonetic Alphabet (SAMPA), a machine readable alphabet. The development of the pronunciation dictionary and the system architecture are also described in the paper. NaviRo pronunciation dictionary is freely available on the project website in HTK (Hidden Markov Model Toolkit) and Festival Speech Synthesis System dictionary format. There are also available for download the used grapheme and phoneme set and the audio samples for the used phonemes. The use of these resources is completely unrestricted for any research purposes in order to promote Romanian language speech technology research.
Increasing the scope of co2-utilising photoreactions: asymmetric photosynthesis of amino acids

Carbon dioxide is released into the atmosphere at an ever-increasing rate due to the burning of fossil fuels. At the same time, the production of bulk and fine chemistry mostly relies on the same crude oil as a carbon source. This situation is unsustainable and therefore calls for the recycling of CO2 as a carbon source. State-of-the-art methods are not sufficient to balance the carbon cycle and therefore it is important to increase the scope of available reactions using CO2. In this proposal, we aim to develop a new methodology using CO2 as a C1-synthon to open up new synthetic pathways. We will bind CO2 to a metal centre and use a radical-coupling pathway to form C-C bonds through an atom-efficient transformation. In this way, we aim to synthesise both natural and unnatural chiral amino acids from amines using visible light and combined photoredox- and CO2-catalysis. The project will contribute to uphold Europe as a world-leader in sustainability by developing novel green methodologies, as well as maintain it as a respected destination for outstanding research by dissemination of the results to both experts and a broader audience. Furthermore, the highly interdisciplinary project and extensive training will prepare the researcher to pursue a successful career in sustainable chemistry.
Framework cooperativo per l’infomobilità intermodale interregionale delle persone

The project 3i addresses the problem of accessibility simply trying to promote regional integrated mobility (inter) of the areas concerned with regard to intermodal transport (private mobility and public transport) of persons (citizens / general user). 
Systems and services produced in the future with 3i will be made available on the territory of cooperation. 
The project aims to create the basis for cooperation in the future information infrastructure for the mobility, which facilitates the movement of people into a strong logic of integration and intermodality; through integration between different modes of transport (private vehicles, bus, ship, plane, train), will be reduced travel time and unnecessary journeys.We want to involve all the actors who act in the process of mobility management. We recognize three basic categories: supplier (holders of information: the PA, which typically issue orders on the accessibility conditions of the road network), managers (: actions of those responsible for processing the basic information provided by the supplier, typically the regional administrations) , users (users: among the latter are all citizens / users of the regions concerned and the various organizations involved in the process). 
The main activities and tasks planned to achieve the general objective stated above can be summarized as follows: 
• In-depth study of the cooperation area in terms of accessibility and territorial conditions of supply and demand for mobility; 
• Design and development of systems for communication with users of mobility within the area of ​​interest and for the management and analysis of the application; 
• Define a governance model and business architecture for ITS services.
Historicizing the Uses of the Past

This book presents new developments in Scandinavian memory cultures related to World War II and the Holocaust by combining this focus with the perspective of history didactics. The theoretical framework of historical consciousness offers an approach linking individual and collective uses and re-uses of the past to the question how history can and should be taught. It also offers some examples of good practice in this field. The book promotes a teaching practice which, in taking the social constructivist notions of historical consciousness as a starting point, can contribute to self-reflecting and critical thinking -- being fundamental for any democratic political culture.
CNC stroj za graviranje - konstrukcija mobilne izvedbe stroja za obradu granita

Although the hand-engraving granite and granite blasting is still very much present, appeared
in the modern world the need for faster and more precise production of engravings and
inscriptions on granite surfaces. The big problem appears in situations when we try to make
engravings and inscriptions directly on granite monuments or granite slabs of large dimensions
which can not be set as the workpiece on the machine tool. Also, engraving machines and
machines that produce images one can find today on the market are dependent on electricity
(must be connected to the grid or generator).
For all these reasons, mobile engraving granite machine will come to the fore. It will shorten
the time of production, increase productivity, and also we do not need electricity connected to
cable, but we have a battery with which we can work a few hours.
SIMULTANEOUS QUANTITATIVE MULTIPLE PRIMER DETECTION OF CLOSTRIDIUM DIFFICILE

This invention comprises a multiplex-capable oligonucleotide which is capable of hybridizing to at least one of the C. difficile tcdB, tcdC, or cdtB genes, wherein, wherein said primer consists of a sequence selected from the group consisting of SEQ ID NOS: 1 through 9, or a sequence that exhibits no more than one substitution of a base to a sequence selected from the group consisting of SEQ ID NOS: 1 through 9 and method for polymerase chain reaction (PCR) determining of the presence of a toxigenic strain of C. difficile in a biological sample utilizing said probes.