SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Mechanism and consequences of the interplay between mitosis and human papillomavirus initial infection

Human Papillomavirus Type 16 (HPV16), the paradigm cancer-causing HPV type, is a small, nonenveloped, DNA virus characterized by its complex life cycle coupled to differentiation of squamous epithelia. Due to this complexity, how HPV16 infects cells is an understudied field of research. Our previous work to define the cellular pathways that are hijacked for initial infection revealed uptake by a novel endocytosis mechanism, and the requirement for mitosis for nuclear delivery. Our findings indicated that nuclear envelope breakdown was required to access the nuclear space, and that the virus associated with mitotic chromatin during metaphase. This prolonged mitosis, a process beneficiary for infection. The viral L2 protein as part of incoming viruses mimics this on its own. The aim of this proposal is to reveal how HPV16 differentially modulates or takes advantage of the mitotic machinery for nuclear import in cells, tissues or during aging, and whether malignant cellular consequences arise. On the viral side, we will define the minimal properties of L2 to mediate association with cell chromatin and mitosis prolongation. On the cellular side, we will identify the protein(s) that mediate recruitment, and how it occurs in a detailed temporal/spatial manner. To elucidate the mechanism of mitotic prolongation and consequences thereof, we will identify which regulatory complex of mitosis is targeted, how it is induced, and whether it causes DNA damage or segregation errors. Finally, we will ascertain the influence of tissue differentiation and aging on this process. Using systems biology, proteomics, virology, cell biology, biochemistry, and a wide range of microscopy approaches we will unravel the complex interactions between HPV and the host cell mitosis machinery. In turn, as viruses often serve as valuable tools to study cell function, this work is likely to uncover new insights into how cells spatially and temporally regulate mitosis in differentiation and aging.
Ophthalmologic abnormalities among students with cognitive impairment in eastern Taiwan: The special group with undetected visual impairment

Students with cognitive impairment are at increased risk of suffering from visual impairment due to refractive errors and ocular disease, which can adversely influence learning and daily activities. The purpose of this study was to evaluate the ocular and visual status among students at the special education school in Hualien.All students at the National Hualien Special Education School were evaluated. Full eye examinations were conducted by a skilled ophthalmologist. The students' medical records and disability types were reviewed.A total of 241 students, aged 7-18 years, were examined. Visual acuity could be assessed in 138 students. A total of 169/477 (35.4%) eyes were found to suffer from refractive errors, including 20 eyes with high myopia (≤-6.0 D) and 16 eyes with moderate hypermetropia (+3.0 D to +5.0 D). A total of 84/241 (34.8%) students needed spectacles to correct their vision, thus improving their daily activities and learning process, but only 15/241 (6.2%) students were wearing suitable corrective spectacles. A total of 55/241 students (22.8%) had ocular disorders, which influenced their visual function. The multiple disability group had a statistically significant higher prevalence of ocular disorders (32.9%) than the simple intellectual disability group (19.6%).Students with cognitive impairment in eastern Taiwan have a high risk of visual impairment due to refractive errors and ocular disorders. Importantly, many students have unrecognized correctable refractive errors. Regular ophthalmic examination should be administered to address this issue and prevent further disability in this already handicapped group.
Geometrically defined basis functions for polyhedral elements with applications to computational electromagnetics

In the recent years, reformulating the mathematical description of physical laws in an algebraic form using tools from algebraic topology gained popularity in computational physics. Physical variables are defined as fluxes or circulations on oriented geometric elements of a pair of dual interlocked cell complexes, while physical laws are expressed in a metric-free fashion with incidence matrices. The metric and the material information are encoded in the discrete counterpart of the constitutive laws of materials, also referred to as constitutive or material matrices. The stability and consistency of the method is guaranteed by precise properties (symmetry, positive definiteness, consistency) that material matrices have to fulfill. The main advantage of this approach is that material matrices, even for arbitrary star-shaped polyhedral elements, can be geometrically defined, by simple closed-form expressions, in terms of the geometric elements of the primal and dual grids. That is why this original technique may be considered as a “Discrete Geometric Approach” (DGA) to computational physics. This paper first details the set of vector basis functions associated with the edges and faces of a polyhedral primal grid or of a dual grid. Then, it extends the construction of constitutive matrices for bianisotropic media.
Improving wet plastic recycling through innovative lagrangian particle-fluid simulations

Wet particle separation is used widely in mineral processing as well as plastic recycling to separate mixtures of particulate materials into further usable fractions due to density differences. Despite its wide usage wet particle separation processes are often attributed to operational problems especially if density differences of the feed material are low. A review of the state of the art clearly indicates that numerical modelling has not yet been applied to wet separation processes due to the lack of applicable numerical schemes. On this background numerical modelling can strongly contribute towards improving the design and process parameters of wet particle separation technologies especially in the field of plastic recycling - improvements have a strong environmental impact such as reduced landfill and lower overall pollution.

The proposed research consists of two parts. The first objective is the development of a novel, fully Lagrangian particle-fluid modelling framework applicable to systems of particles of complex shape in a wet environment. For modelling the particles, the Discrete Element Method (DEM) will be employed. For the fluid part, the Lagrangian Smooth Particle Hydrodynamics (SPH) will be used which enables handling free surfaces and large movements of the fluid, inherently. While unresolved fluid flow around particles is already used in mesh based methods, coupling the DEM and SPH in one computational framework is a challenging task addressed in this project. Thereby, a framework is developed for representing technical scale systems of complex shaped particles in a wet environment for the first time. In the second part of the project, the developed framework will be applied to the modelling of a wet separation process involving a sink-float drum separator for plastic recycling. Both design and operational parameters will be optimized and results exchanged towards technology improvements with interested European companies from the recycling sector.
SYSTEM WITH WIRELESS INTEGRATED SPA TOPSIDE CONTROL PANEL

Embodiments of the present invention advantageously locate a wireless transceiver within the "topside" control panel of a spa. The wireless transceiver can communicate with a remote controller for control signal communication and to receive data (e.g., music). Since the wireless transceiver of the present invention is located "topside," it avoids the interferences and blockages associated with lower mounted transceivers. Further, since the transceiver is located on the topside controller, there is no need to run a wired communication bus from the Spa pack main controller to a lower mounted transceiver, as done in the prior art systems. Instructions received wirelessly to the topside controller are formatted and sent to the Spa pack main controller. The wireless commands received through the topside controller are passed to the Spa pack main controller and can control all the spa equipment, including, heaters, pumps, lights, speakers, cleaning systems, jets, etc.
Fluorodeoxyglucose positron emission tomography/computerized tomography in differentiated thyroid cancer management: Importance of clinical justification and value in predicting survival

The purpose of this study was to evaluate the added value of follow-up fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET/CT) to clinical assessment and predicting survival outcome in patients with differentiated thyroid cancers.This is an institutional review board approved, retrospective study of 202 biopsy-proven thyroid cancer patients at a single tertiary centre. A total of 327 follow-up or surveillance PET/CT scans done 6 or more months from initial treatment completion were included in this study. Median follow-up from completion of primary treatment was 94 months (range, 6.17-534.1 months). Overall survival benefit was measured using Kaplan-Meier plots with a Mantel-Cox log-rank test. Multivariate Cox regression model is provided with clinical covariates.Of the 327 PET/CT scans from 202 patients, 161 were positive and 166 as negative for recurrence or metastasis. A total of 23 patients died during the study period. Patients with a positive PET/CT scan had shorter overall survival than those who had a negative scan (P < 0.0001, hazard ratio 6.1 (3.0-14.3) ). In the context of clinical assessment, PET/CT identified recurrence in 50% (25/50) of scans without prior clinical suspicion and ruled out recurrence in 36.8% (102/277) of scans with prior clinical suspicion. In a multivariate Cox regression model, factors associated with overall survival were stage (P < 0.0001), time to scan (P = 0.0005) and PET/CT result (P < 0.0001).FDG PET/CT performed in follow-up more than 6 months from primary treatment completion adds value to clinical judgment and a prognostic marker of overall survival in thyroid cancer patients.
Activities on drone integration and demonstration in vll operations

The scope of the SAFEDRONE project is to acquire practical experience in Very Low Level (VLL) operations where general aviation, state aviation and optionally piloted aircrafts and drones will share the airspace. It is important to highlight that this project will have a clear practical focus which primary activities will be innovation, integration, and especially, demonstrating activities with flight tests.

The specific objectives of SAFEDRONE are the following: 

1. Demonstrate how to integrate general aviation, state aviation, optionally piloted aircrafts and drones into non-segregated airspace in a multi-aircraft and manned flight environment, in order to explore the feasibility of U-Space vision by 2019.

2. Perform a large number of demonstrations in order to accumulate evidences and experience about the required services and procedures necessary to operate drones in a safe, efficient and secure way within U-Space.

3. Validate proof of concept implementations of a large variety of U-Space services and procedures.

4. Provide evidences to EASA and National Aviation Authorities to reinforce the safe integration of drones under U-Space for the different drone categories. Also, the lessons learnt and the technologies used during the project will be proposed to the different standardization bodies.

5. Coordination with the recently approved SESAR-RPAS projects in order to align the demonstrations with the CONOPS and technological developments of these projects. 

6. Increase the awareness of the advances in U-Space within Europe through the dissemination of the obtained results. 

Finally, SAFEDRONE consortium is formed by 2 private companies (INDRA and UNIFLY), 2 government-owned companies (IAI and ENAIRE), two aeronautical research centres (CATEC and CRIDA) and one university (University of Seville) obtaining a balance among accessing to novel technology, integration and operational experience, and orienting the demonstrations towards real market needs.
Tra utopia e alteritá

A partire dal III secolo a.C. si delinea in maniera più nitida quella feconda ma, al tempo stesso, ambivalente relazione tra Egitto e Roma. Con la stipula del trattato di amicitia nell’anno 273 a.C., appaiono sempre più evidenti le ripercussioni sul piano politico, culturale, economico e religioso sul suolo italico. Peculiare interesse riveste anche il ruolo della produzione artistica generata dall’incontro-scontro tra il mondo romano e quello egiziano. In particolare, l’interesse di questo contributo è indirizzato verso l’elaborazione del paesaggio ispirato alla terra del Nilo nella produzione pittorica romana di I secolo d.C. La delineazione di questa tipologia iconografica si fonda su alcuni dettagli figurativi specifici, tra cui quelli legati al mondo della flora e della fauna. Un insieme di elementi che, fondendosi armoniosamente insieme, conducono verso la configurazione di un’ambientazione naturale tesa ad un’ideale di fluttuante utopia che, tuttavia, collide con l’insita portata di alterità dell’immaginario nilotico. Un’alterità fortemente vincolata alla presenza dei pigmei, figure contraddistinte nella maggior parte dei casi da tratti caricaturali e grotteschi, inseriti spesso in situazioni comiche, se non paradossali. Obiettivo del presente articolo è quello di mettere in luce la relazione chiaroscurale tra la “natura” costituente il paesaggio nilotico, ovvero la flora e la fauna tipica, riflesso di una cristallizzata utopia naturalistica, e l’elemento umano, in questo caso i pigmei, sinonimo di alterità per antonomasia, concretizzazione non tanto di una realtà esistente quanto più di uno status estraneo ai limiti del tempo e dello spazio umanamente concepiti.
Gain Estimation of a Digital-to-Time Converter for Phase-Prediction All-Digital PLL

We propose a gain estimation technique of a digital-to-time converter (DTC) and a time-to-digital converter (TDC) intended for an all-digital phase-locked loop (ADPLL) that is based on a recently introduced phase-prediction (PP) technique. Such a PP-ADPLL reduces the timing range and thus complexity of the fractional part of the phase detection mechanism. The conventional TDC gain estimation methods based on measuring the DCO clock period are not feasible for PP-ADPLLs due to the TDC timing range being much smaller than one DCO clock period. The proposed gain estimation method can run concurrently with the normal ADPLL phase locking process and its feasibility is confirmed through behavioral simulations. Although the estimation method is specifically proposed for the PP-ADPLL, its operating principle can also be applied to conventional ADPLL architectures that require an accurate TDC gain estimation.
European quality in preclinical data

Pharmaceutical industry, as well as basic science, depend on robust data and scientific rigor as key drivers for decision making, patent strength and time-to-market, which in turn will determine knowledge gain and availability of new treatments to patients. Recent publications report challenges with the robustness, rigor, and/or validity of research data, which may impact decisions about whether to proceed to preclinical and clinical testing as well as conclusions on the predictability of preclinical models. There is a need for simple, sustainable solutions that facilitate data quality.
 
We will propose simple, sustainable solutions that facilitate data quality without impacting innovation and freedom of research. Our consortium will pool resources from both academia and industry to pilot this action in Neuroscience and Safety, but with applicability beyond these R&D areas.
The European Quality In Preclinical Data (EQIPD) consortium will 
(i)                  define those variables in study design and data analysis that influence outcome in pre-clinical neuroscience (focus on Alzheimer’s disease and psychosis) and (neuro-)safety studies conducted in industry; and establish whether these are the same variables which influence outcome in academia;
(ii)                define the components which will make up the EQIPD quality management system;
(iii)               define consensus quality management recommendations for non-regulated R&D;
(iv)               validate the feasibility of the quality management system in prospective studies;
(v)                deliver an online educational platform providing certified education and training in the principles and application of quality and rigour. 
 
We will use systematic review and meta-analysis of historical data sets from industry and academia to identify variables of study design which determine outcomes in preclinical studies. Informed by the outcome of these analyses, we will use a Delphi approach to reach consensus around core principles for preclinical robustness, validate these approaches in cross site experiments and establish ring testing experiments in non-regulated research. We will develop a quality system framework to attest to compliance and a governance system to ensure sustainability and relevance. We will develop an educational platform to ensure research community-wide expansion of knowledge on criteria and principles necessary to address robustness and quality.
Junior researchers are involved in many of the tasks and are enrolled in an academia/industry joint exchange scheme. They will form the core from where a cultural change should emerge in form of a ripple effect.
Consortium members have made pivotal scientific and policy contributions relating to the robustness, rigor and validity of pre-clinical research in the past and together have the know-how and infrastructure necessary to succeed in this highly ambitious project.
Delivery of Basic Fibroblast Growth Factor Using Heparin-Conjugated Fibrin for Therapeutic Angiogenesis

Heparin-conjugated fibrin (HCF, a mixture of heparin-conjugated fibrinogen and thrombin) was developed as an injectable carrier for long-term delivery of fibroblast growth factor 2 (FGF2), and the therapeutic potential of the HCF system was investigated by evaluating neovascularization in a mouse hind limb ischemia model. HCF released FGF2 for a much longer period than normal fibrin containing free heparin in vitro. The FGF2 released from HCF was bioactive, as it stimulated growth of human dermal fibroblasts in a serum-depleted medium in vitro. In contrast, FGF2 released from normal fibrin did not induce significant cell growth, probably because of its short-term release. HCF alone, HCF loaded with FGF2, and normal fibrin containing free heparin and FGF2 were implanted into mouse ischemic hind limbs for 4 weeks. Histological analysis, Western blot analysis, and immunohistological analysis revealed that ischemic limbs treated with normal fibrin containing free heparin and FGF2, or treated with HCF only, showed severe muscle fibrosis, inflammation, and a low vasculature density. In contrast, mice treated with FGF2-loaded HCF showed significantly reduced muscle fibrosis and inflammation, and dramatically enhanced neovascularization. FGF2 delivery using HCF could be useful for therapeutic angiogenesis as HCF delivery enhances the therapeutic efficacy of FGF2.
Towards a new sociology of innovation The case of bioenergy in Norway and Sweden

There is widespread agreement that the mitigation of climate changes requires societies across the globe to speed up the diffusion of renewable energy technologies. This article pursues an interest in the diffusion of one such technology: bioenergy. It does so through a study of how bioenergy is covered and communicated in the news media of Norway and Sweden, countries where the diffusion of this technology looks radically different. Mobilizing a domestication perspective, it finds that the news media in the two countries ascribe diverging meaning to the technology, offering audiences clearly varied images of what bioenergy “is.” In other words, the technology is domesticated in different ways, suggesting that media coverage plays a role in systems of innovation and diffusion. How this affects the public, however, is an under analyzed element in the innovation and diffusion literature, and the article calls for further investigation into this matter.
Sexual Sensation Seeking and Internet Sex-Seeking of Middle Eastern Men Who Have Sex with Men

Despite recent evidence of stabilization in many developed nations, new human immunodeficiency virus (HIV) infections remain a public health concern globally. Efforts remain fragile in a number of world regions due to incomplete or inconsistent social policies concerning HIV, criminalization of same-sex encounters, social stigma, and religious doctrine. Middle Eastern men who have sex with men (MSM) remain one of the most hidden and stigmatized of all HIV risk groups. High-risk sexual bridging networks from these men to low prevalence populations (e.g., to spouse to offspring) are emerging HIV transmission pathways throughout the region. This cross-sectional, exploratory study investigated Sexual Sensation Seeking Scale (SSSS) scores to predict numbers of recent MSM sexual activities and to predict any recent unprotected receptive anal intercourse (URAI) activities in 86 Middle Eastern MSM who resided in the Middle East and who used the Internet to sex-seek. In a multivariate hierarchical regression, higher SSSS scores predicted higher numbers of recent MSM sexual activities (p = .028) and URAI (p = .022). In a logistic regression, higher SSSS scores increased the likelihood of engaging in URAI activities threefold (OR 3.0, 95 % CI 1.15-7.85, p = .025). Age and drug/alcohol use during sexual activities served as covariates in the regression models and were not significant in any analyses. Despite numerous hurdles, adopting Internet-based, non-restricted HIV education and prevention public health programs in the Middle East could instrumentally enhance efforts toward reducing the likelihood of new HIV transmissions in MSM and their sexual partners, ultimately contributing to an improved quality of life.
Creating a Platform for Precise Anti-Cancer Medicine

Therapeutic strategies that are based on the individual genetic profile of a patient represent a new frontier of applied cancer research. These strategies are expected to reduce the socio-economic impact of current cancer therapies that are cost-intensive and often ineffective, thus releasing pressure on regional health systems. In this context, tumor-organoids are of special relevance. Tumor-organoids are three-dimensional cellular complexes that are cultivated in vitro from cells that were previously obtained from patient tumors or biopsies. Tumor-organoids have the special property to mirror the key-features of the original patient’s tumor. Thus, Tumor-organoids represent an ideal tool to develop patient-specific therapies by performing drug-screenings. _x000D_
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The PreCanMed project aims to strengthen the collaboration between Italian and Austrian institutions that perform genetic, clinical and biotechnology research in order to establish a common competence-platform for the generation, cultivation and storage (Live-biobank) of numerous patient-derived Tumor-organoids. Tumor-organoids and know-how will be freely accessible, thus making this cutting edge technology accessible to the academic, translational, clinical and pharmaceutical research and development sector.