SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
METHOD AND DEVICE FOR MANUFACTURING OF INSULATING PIPE SECTION FROM MINERAL WOOL

FIELD: construction industry. ^ SUBSTANCE: according to presented method for forming of, actually, cylindrical insulating blank, cotton-wool is supplied in form of loose material to spacing between core and, actually, cylindrical external form enclosing core. For fixation of form of pipe section blank its inner and outer surfaces are heat-treated by means of heating of at least part of core and external form. Then processing of unprocessed layer located between processed inner and outer surfaces is performed. Forming device contains area of pipe section formation, this area consists of core and, actually, cylindrical external form enclosing it, and also of device for final thermal processing of formable pipe section. ^ EFFECT: invention provides continuity of process of pipe section forming, absence of waste material, it allows to change length of product depending on customer's requirements. ^ 28 cl, 3 dwg
Targeted intracellular delivery of antitubercular agents by functionalized nanocapsules

Tuberculosis (TB) is still a major public health problem worldwide. It is estimated that more than one-quarter of the world's population is infected with this airborne infectious disease. Moreover, the increase of multidrug- and extensively drug-resistant TB is alarming. TB is caused by Mycobacterium tuberculosis, an intracellular pathogen that can survive in host cells, mainly in macrophages. The uptake of the antitubercular drugs by infected host cells is limited. The orally or intravenously administered drugs are distributed throughout the body causing side effects and the majority of the drug molecules do not reach their targets. The elimination of the intracellular bacteria could be more efficient with host cell directed delivery. The TBNANO project aims to develop and in vitro evaluate antitubercular agent-loaded nanocapsules decorated with host cell targeting molecules. For this purpose, naturally occurring, biocompatible and biodegradable polysaccharide nanocapsules loaded with a recently approved anti-TB drug (bedaquiline) and antimicrobial peptides will be used. The surface of the nanocapsules will be functionalized with macrophage targeting ligands, such as peptides and mannose derivatives. With such nanotechnology-based drug delivery system, enhanced cellular uptake can be achieved by the host cell macrophages, therefore, the anti-TB agent can reach the intracellular bacteria as site of action. This approach leads to increased bioavailability and selectivity of the drugs while reducing their undesirable side effects. The proposed project could provide a breakthrough step in nanotechnology-based TB treatment to get closer to a world free of TB. Furthermore, this multidisciplinary project provide valuable transfer of knowledge to the host institution, as well as advanced training of the young researcher in the field of nanomaterial science to broaden her expertise in drug delivery systems.
Theoretical and experimental study of dimethyl sulfoxide and N-substituted DMSO

Infrared spectrum of dimethylsulfoxide (DMSO) has been studied using quantum chemical calculations and FTIR spectroscopy. Theoretical infrared and electronic absorption spectra for the ions of DMSO, DMSO in water solvent and nitrogen substituted DMSO (N-DMSO) have also been obtained using second order Moller-Plesset and 6-311++g(d,p) basis set. The IEFPCM model has been used to study the solvation effect for DMSO. The geometrical parameters and dipole moments for the neutral DMSO have been compared with the available experimental determinations. Calculated vibrational frequencies have been compared with the experimental frequencies for the DMSO obtained using FTIR spectrometer. Rotational and centrifugal distortional constants for these molecules have been reported. The electronic absorption spectra of DMSO, its ions, and N-DMSO have been obtained using time dependent density functional theory (TDDFT) approach. Almost all the vibrational modes in the vibrational spectrum of DMSO anion are intense whereas fewer intense modes have been observed in the vibrational spectra of DMSO, its cation, DMSO in water solvent and N-DMSO. The most intense mode is different for DMSO, its ions and N-DMSO. The S=O stretching mode is the most intense mode for DMSO as well as DMSO in water solvent and it is red shifted by 62 cm -1 in latter than the former.
Geomagnetic conjugate observations of plasma-sheet electrons by the FAST and THEMIS satellites

[1] We investigate pitch-angle distributions and spectral shapes of auroral electrons simultaneously observed during three conjunction events by the FAST satellite at altitudes of 2500–3500 km and by the THEMIS satellite in the plasma sheet at 7–13 RE. All three events were on the lower latitude of the auroral oval. Conjunction event 1 occurred at ~1914:45 UT on 10 April 2008. Electron spectra at energies of 0.1–3 keV are correlated well between the two satellites, while the precipitating electrons above 3 keV are missing at FAST. Event 2 occurred at 1255:26 UT on 26 April 2008. Electron spectra above 3 keV are correlated well between the two satellites. An additional broad spectral peak at energies of 0.1–0.5 keV was observed by FAST. Event 3 occurred at 0058:04 UT on 25 December 2008. Precipitating electrons of 0.5–5 keV obtained by FAST are correlated well with those of THEMIS-C, while a monoenergetic peak at 0.1–0.2 keV was observed only by FAST. For the three conjunction events, we conclude that high-energy precipitating auroral electrons observed by FAST directly come from the equatorial plasma sheet, while low-energy precipitating electrons may come from middle altitudes as a result of acceleration by static potential differences. For missing high-energy (>3 keV) electrons of event 1, we speculate that the pitch-angle scattering by waves occurs only at a limited energy range.
Enigmatic Liaisons in Lepidoptera: A Review of Same-Sex Courtship and Copulation in Butterflies and Moths

Same-sex sexual interactions (SSSI) have been observed in many animal groups and have intrigued evolutionists. In this paper, reports on SSSI in Lepidoptera are reviewed and evolutionary hypotheses that could explain these behaviors are discussed. SSSI have been documented in males of 25 species and in females from role-reversed populations of one species. Four types of SSSI have been reported: pupal guarding, courtship, copulation attempt, and copulation. Although the hypotheses cannot be tested with the limited data, evidence suggests that in some Lepidoptera SSSI could result from selection for imposing costs on other males, or could be a by-product of sexual selection favoring individuals that exhibit high sexual willingness. In agreement with both hypotheses, in the 17 species whose mating systems are known, there is intense competition for mates in the sex exhibiting SSSI. We propose lines of research on SSSI in Lepidoptera.
Functional adjustment of Fernetti traffic centre, in keeping with the new customs provisions, with special regard to the setting up of Fernetti - Sežana Logistic Platform at the time of Slovenian entry into the European Union (main works functional lot)

As is known, the process of functional upgrading of cross-border traffic centres is made necessary by the entry of the Republic of Slovenia in the European Union and the new customs provisions. This project falls within said context and is aimed at the creation of the Fernetti-Sežana freight yard with two connected import-export sections in order to significantly reduce the operation time. From a technical point of view, the project consists of two parts: the first regarding main works, the second complementary works. As far as the main works for the construction of the freight yard are concerned, an interconnecting shed will be built between warehouses, internal and external roads will be re-organized through the re-asphalting of the tracks and the yards and public green space will be renovated. The traffic centre will also be equipped with specific IT technology (software, hardware and optic fibre) for the creation of the single freight yard. The initiative also requires the drawing up of a survey on the implementation of a comprehensive development plan for the Terminal - starting with the examination of legislative and bibliographical documentation available regarding inter-port facilities and the transport system in general - and the reconversion of the enterprises operating inside the centre.
Impact of rna modifications on neuronal fate

The Epitranscriptome is the assembly of over 170 chemical RNA modifications that play fundamental roles in the majority of cellular processes. RNA modifying enzymes and proper control of neuronal cell fate are essential for brain development and dysfunction in any of these processes results in severe neurodevelopmental disorders. To date, the role of non-coding RNAs (ncRNAs) as key regulators of sophisticated molecular pathways is becoming increasingly clear. A key regulatory ncRNA that modulates the transcriptional output of RNA polymerase II is Rn7sk. Other abundant ncRNAs, like transfer RNAs and ribosomal RNAs, are highly modified; yet the modifications occurring in Rn7sk are largely unknown. In this proposal, I aim to investigate the Rn7sk RNA modification status and the impact of these modifications on neuronal cell fate and brain development. To accomplish this, I will; i) Characterize Rn7sk RNA modifications using a highly sensitive RNA mass spectrometry approach and evaluate the impact of selected modifications in recruiting protein binding partners using stable isotope labelling by amino acids in cell culture (SILAC) based mass spectrometry; ii) Determine the biological function of selected Rn7sk modifications during neuronal differentiation using genetically manipulated embryonic cell lines; iii) Investigate the role of Rn7sk during brain development using genome-wide sequencing technologies and a forebrain-specific Rn7sk knock-out mouse model. Results stemming from this project will reveal several novel aspects about how neuronal fate is controlled by tiny RNA modifications. My ultimate ambition is to establish my own laboratory and become an independent research leader in the field of Epitranscriptomics. This proposal, with the support from the experienced Prof Frye and the excellent host institute, DKFZ, is key for me to reach my goal.
Topological nano-photonics

One of the most fascinating phenomena in nature is the interplay between quantum mechanics and the flow of electrons in solids. A tangible example is the quantum hall effect, where electrons flow with virtually zero dissipation. That is because electrons can flow only in one direction, which makes them move around objects without scattering, representing robustness by topological protection. Essential for this effect is the magnetic field that breaks time-reversal symmetry.

Recently, however, with the advent of novel exotic quantum materials, completely new concepts for topological and non-reciprocal phenomena have appeared on the horizon, without the need to apply any magnetic field. These materials exhibit intrinsic topological character due to quantum mechanical interferences. TOPONANOP’s vision is to exploit these extraordinary quantum properties in order to control light at the nanoscale in a radically new way. One of the main objectives is to generate nanoscale optical fields (plasmons) that propagate in only one direction and implement topologically protected plasmons such that they move around defects and corners. At the same time, visualizing and controlling electromagnetic excitations will be used as a tool to unravel extraordinary phenomena in exotic quantum materials. 

To this end, TOPONANOP will apply novel low-temperature, THz and infrared, near-field imaging and spectroscopy techniques to directly spatially visualize the plasmon non-reciprocity and topological character.
Topological nano-photonics is a new paradigm for novel quantum materials and will enable novel future applications in miniaturized photonic isolators, diodes and logic circuits and could lead to completely new concepts for communication systems, optical transistors and optical information processing.
A clinical, randomized, controlled study on the use of desensitizing agents during tooth bleaching

To evaluate the efficacy of experimental proposals of desensitizing agents during tooth bleaching.140 participants without tooth sensitivity (TS) received 16% carbamide peroxide (14 days-04 h each) (T1) or 35% hydrogen peroxide (single session-45 min) (T2). Participants used concomitantly (10 per group): desensitizing dentifrices (D1-experimental bioactive glass-ceramic; D2-commercial potassium nitrate; D3-commercial calcium and sodium phosphosilicate) in-home, daily and, desensitizing pastes (D4-experimental bioactive glass-ceramic; D5-experimental Bioglass type 45S5; D6-commercial calcium phosphate), in-office, immediately after the treatment and more 4 times. Participants in the control group did not use any desensitizing agent. We assessed TS with Visual Analogue Scale. Assessment point 1 was immediately after the first participant's exposure to the treatments; and points 2, 3, 4, and 5 were every 72 h along the period of the study. Two-way ANOVA (considering time and desensitizing as factors) and post-hoc Tukey test (α=0.05) analyzed the data.In the control group treated with 35% hydrogen peroxide, TS increased significantly on assessment points 1 and 2. The participants who used a 5% potassium nitrate dentifrice and in-office experimental pastes did not experience TS because of the 35% in-office bleaching treatment.TS caused by 35% hydrogen peroxide in-office tooth bleaching was controlled by experimental products prepared as pastes D4-experimental bioactive glass-ceramic and D5-experimental Bioglass type 45S5, but not by D1-experimental dentifrice containing bioactive glass-ceramic.There is no a gold standard protocol for TS caused by tooth bleaching. The study of novel desensitizing agents that can obliterate the dentinal tubules in a faster-acting and long-lasting way may help meet this clinical need.
Infilling Monthly Rain Gauge Data Gaps with Satellite Estimates for ASAL of Kenya

Design and operation of water resources management systems in sub-Saharan Africa suffer from inadequate observation data. Long running uninterrupted time series of data are often not available for water resource planning. Incomplete datasets with missing gaps is a challenge for users of the data. Inadequate data compromise results of analyses leading to wrong inference and conclusions of scientific assessments and research. Infilling of missing sections of data is necessary prior to the practical use of hydrometeorological time series. This paper proposes the use of Tropical Rainfall Measuring Mission satellite data as a viable alternate source of infill for missing rain gauge records. The least square regression method, using satellite-based estimates of rainfall was tested to fill in the missing data for 153 data points at nine rain gauge stations in Machakos, Makueni and the Kitui region of Kenya. Results suggest that the satellite rainfall estimates can be used as an alternative data source for rainfall series where the missing data gaps are large. The infilled data series were used in the development of monitoring, forecasting and drought early warning for Arid and Semi-Arid Lands (ASAL) in Kenya.
Some aspects of the Upper Palaeolithic period in Sindh, Pakistan

The study of the Upper Palaeolithic of Sindh is still in its infancy. Although it has slightly improved during the last twenty years, and a few more sites have been discovered in different parts of the province, we are still far from achieving a good knowledge of the sequence of the events that took place during the final stages of the Pleistocene in this region of the Indian Subcontinent. Despite the archaeological importance of the southern part of the country, the Arabian Sea coast in particular, which represents the suggested route followed by Modern Humans to move to India and farther east, most of this territory has not yielded any tangible trace of their passage. The scope of this paper is to update the evidence available for the Upper Palaeolithic of Sindh, and to discuss it within the general framework of the Upper Palaeolithic period of the Indian Subcontinent. L’étude du Paléolithique supérieur du Sindh en est encore à ses balbutiements. Bien qu’elle se soit légèrement améliorée au cours des vingt dernières années et que quelques sites supplémentaires aient été découverts dans différentes parties de la province, nous sommes encore loin d’avoir une bonne connaissance de la séquence des événements qui se sont déroulés lors des étapes finales du Pléistocène dans cette région du sous-continent indien. Malgré l’importance archéologique de la partie sud du pays, la côte de la mer d’Oman en particulier, qui représente la route suggérée suivie par les humains modernes pour se déplacer vers l’Inde et plus à l’est, la majeure partie de ce territoire n’a livré aucune trace tangible de leur passage. Le but de cet article est de mettre au jour les preuves disponibles pour le Paléolithique supérieur du Sindh et de les discuter dans le cadre général de la période du Paléolithique supérieur du sous-continent indien.
Pathways to math difficulties -a longitudinal study from birth to school-age

EARLYMATH is an early-onset longitudinal research program with multiple longitudinal studies that cover birth to nine years of age in order to pursue an integrative understanding of early math development and pathways to math difficulties (MD). EARLYMATH investigates the roles of individual factors (i.e., neural, cognitive, affective and motivational), as well as environmental factors in the home and early childhood education and care (ECEC) and processes of intergenerational transmission of MD. A carefully selected range of measures, including cognitive assessments, parental and teacher questionnaires, interviews, parent-child and classroom observations, and brain electrophysiology measures, will be used. The findings will produce novel understanding of the dynamics of the environmental and constitutional factors that affect the development of early-onset developmental difficulties, as well as inform theory and preventive and remediation practices.
Management of adults and children receiving CAR T-cell therapy: 2021 best practice recommendations of the European Society for Blood and Marrow Transplantation (EBMT) and the Joint Accreditation Committee of ISCT and EBMT (JACIE) and the European Haematology Association (EHA)

Several commercial and academic autologous chimeric antigen receptor T-cell (CAR-T) products targeting CD19 have been approved in Europe for relapsed/refractory B-cell acute lymphoblastic leukemia, high-grade B-cell lymphoma and mantle cell lymphoma. Products for other diseases such as multiple myeloma and follicular lymphoma are likely to be approved by the European Medicines Agency in the near future.The European Society for Blood and Marrow Transplantation (EBMT)-Joint Accreditation Committee of ISCT and EBMT (JACIE) and the European Haematology Association collaborated to draft best practice recommendations based on the current literature to support health care professionals in delivering consistent, high-quality care in this rapidly moving field.Thirty-six CAR-T experts (medical, nursing, pharmacy/laboratory) assembled to draft recommendations to cover all aspects of CAR-T patient care and supply chain management, from patient selection to long-term follow-up, post-authorisation safety surveillance and regulatory issues.We provide practical, clinically relevant recommendations on the use of these high-cost, logistically complex therapies for haematologists/oncologists, nurses and other stakeholders including pharmacists and health sector administrators involved in the delivery of CAR-T in the clinic.
The history of intellectual property rights in the creative industries

CREATIVE IPR aims to study the rise of intellectual property rights in the creative industries, from the international treaties of the late nineteenth century to the present day, with a focus on Europe in the global world. 

CREATIVE IPR examines the consequences of this development for the creators. What did intellectual property rights mean to a musician, or to a fashion designer in twentieth century Europe? Who captured economic value or failed to do so? In order to answer these questions, CREATIVE IPR proposes an original bottom-up approach, examining from the ground the macro and the micro aspects of the rise of intellectual property rights in the creative industries. 
CREATIVE IPR pursues the questions in three arenas. The first arena is the formation and impact of national and international institutions and organizations for intellectual property. The second and third arenas are the role of authors’ rights societies in the music industries, and the management of creativity in the fashion industries. For each arena, cross-cutting themes are pursued: authorship and creativity, firms, technological change, legal frameworks, and the role of the commons – the public domain.

In recent years, intellectual property rights have, due to technological and economic change, attracted significant scholarly interest. Yet attention has not been paid to their impact on creators in a historical perspective. By analyzing the micro histories of the creators who negotiated the growing legal regime in the light of a transnational context CREATIVE IPR will fill a significant knowledge gap, help refine our ideas about the impact of intellectual property rights on creators, and open paths for future research. Ultimately it will help us understand how societies can foster rich and diverse creative industries.
COMPOSITION POUR LA SOUDURE TENDRE

<P>L'invention a pour objet une composition de fondant notamment pour la soudure tendre </P><P>Elle comprend comme constituants essentiels 1 au moins un ester d'un polyalcool et 2 au moins un composant supplémentaire choisi parmi les acides organiques solubles dans ledit ester quand celui-ci est à l'état fondu, des agents d'activation du fondant et des agents de durcissement des résidus du fondant, l'ester étant présent en une proportion d'au moins 25 % par rapport au poids total des constituants 1 et 2. </P><P>Utilisation de la composition pour le soudage des composants électroniques de plaques de circuits imprimés.</P>