SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Fluorofenidone protects against renal fibrosis by inhibiting STAT3 tyrosine phosphorylation

Signaling through the Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway, especially JAK2/STAT3, is involved in renal fibrosis. Fluorofenidone (FD), a novel pyridone agent, exerts anti-fibrotic effects in vitro and in vivo. Herein, we sought to investigate whether FD demonstrates its inhibitory function through preventing JAK2/STAT3 pathway. In this study, we examined the effect of FD on activation of rat renal interstitial fibroblasts, glomerular mesangial cells (GMC), and expression of JAK2/STAT3. Moreover, we explored the histological protection effects of FD in UUO rats, db/db mice, and phosphorylation of JAK2/STAT3 cascade. Our studies found that pretreatment with FD resulted in blockade of activation of fibroblast and GMC manifested by fibronectin (FN) and α-smooth muscle actin (α-SMA) protein expression and decline of STAT3 tyrosine phosphorylation induced by IL-6 or high glucose. In unilateral ureteral obstruction rats and a murine model of spontaneous type 2 diabetes (db/db mice), treatment with FD blocked the expression of FN and α-SMA, prevented renal fibrosis progression, and attenuated STAT3 activation. However, FD administration did not interfere with JAK2 activation both in vivo and in vitro. In summary, the molecular mechanism by which FD exhibits renoprotective effects appears to involve the inhibition of STAT3 phosphorylation.
Straßeninfrastruktur

Das Projekt betrifft die Unterstützung des Betriebskapitals eines Unternehmens im Falle eines Umsatzrückgangs (Umsatzerlöse), der durch die negativen Auswirkungen des COVID-19-Ausbruchs verursacht wird.
Spring contact for an electrical plug-in connection rail.

The invention relates to a spring contact for an electrical plug connection strip having a connecting part which is used for the electrical connection to a printed-circuit board connected to the plug connection strip. In order to distribute higher currents which are to be conducted through the spring contact, the connecting part has at least two connecting tabs (1) which can be soldered or pressed in each case into a corresponding mounting hole in the printed-circuit board. <IMAGE>
The Unintended Consequence of Diabetes Mellitus Pay-for-Performance (P4P) Program in Taiwan: Are Patients with More Comorbidities or More Severe Conditions Likely to Be Excluded from the P4P Program?

Taiwan has instituted a pay-for-performance (P4P) program for diabetes mellitus (DM) patients that rewards doctors based in part on outcomes for their DM patients. Doctors are permitted to choose which of their DM patients are included in the P4P program. We test whether seriously ill DM patients are disproportionately excluded from the P4P program.This study utilizes data from the National Health Insurance (NHI) database in Taiwan for the period of January 2007 to December 2007. Our sample includes 146,481 DM-P4P patients (16.56 percent of the total) and 737,971 non-DM-P4P patients.We use logistic and multilevel models to estimate the effects of patient and hospital characteristics on P4P selection.The results show that older patients and patients with more comorbidities or more severe conditions are prone to be excluded from P4P programs.We found that DM patients are disproportionately excluded from P4P programs. Our results point to the importance of mandated participation and risk adjustment measures in P4P programs.
Resolution of matrix interference: quantitative and quasi-quantitative ligand-binding assays case studies

Background: Matrix effects pose a constant challenge in developing robust ligand-binding assays to be validated for use in nonclinical and clinical study support. When notable matrix effects of any kind are present, it can render an otherwise sound method ineffective. We present two case studies detailing the mitigation of observed matrix effects. Method: A dimeric protein was removed from unknown samples in an anti-therapeutic antibody assay through protein extraction. Nonspecific matrix effects in a quantitative ligand-binding assays were mitigated through development of a specialized buffer. Results: The protein extraction method reproducibly reduced the artificially high responses of naïve samples, enabling the accurate detection of anti-therapeutic antibodies. Design of experiments was used to evaluate and select the optimal components and associated concentrations in order to reduce the observed matrix effect to acceptable limits. Conclusion: Our results suggest there are multiple techniques available for the bioanalytical scientist to mitigate both matrix effects in ligand-binding assays.
MINE ROOF SUPPORT

1487553 Advancing mine roof supports DOWTY MINING EQUIPMENT Ltd 20 Sept 1974 [18 Oct 1973 20 July 1974] 48620/73 and 32251/74 Heading E1P In a mine roof support having an advancing jack 18 connectible to an anchorage such as a conveyor by a relay bar 13, the jack is arranged to exert on the support a force having one component parallel to the direction of advance and another component which lifts the support from the floor. The thrust exerted by jack 18 acts in a straight line between pivot joints 19, 21 as shown, a slot 35 providing a lost motion connection between the jack and the bar 13. The jack is enclosed by a pair of telescopic tubes 27, 28 loaded by a spring-actuated plunger 38. In a modification, see Figs. 4..7 (not shown), the forward end of the jack is pivoted to a bridge member [119] extending between the front edges of the floor beams of the support and the plunger of the jack is pivotally. connected to the end of the relay bar.
A retrospective analysis of preferred and actual place of death for hospice patients

The purpose of this study was to explore recording rates of preferences, and the preferred and actual place of death among hospice patients. Data was collected retrospectively from a group of three hospices over a 6-month period. Of 298 patients, 174 patients (58.4%) had no expressed preference for place of death. The congruence of preferred and actual place of death was: home 52.5%; hospice 86.2%; hospital 100%; and care home 50%. The overall congruence was 61.7% and kappa value was 0.38 (0.23-0.52, 95% confidence interval). The low rate of expressed preferences suggests that congruence of preferred and actual place of death was a suitable outcome measurement for less than half of hospice patients. A wider range of patient-focused indicators for identifying the quality of end-of life services is needed as preferred place of death may not be the only suitable indicator for all patients.
Hydrodynamic Studies of Three-Phase Fluidized Bed by Experiment and CFD Analysis

The complex hydrodynamics of three-phase (gas-liquid-solid) fluidized beds are not well understood due to complicated phenomena such as particle-particle, liquid-particle and particle-bubble interactions. In the present work both experimental and computational studies have been carried out on two and three dimensional fluidized beds to characterize there hydrodynamic behavior. Air, water and low density solid particles have been used as the gas, liquid and solid phase to analyze the system behaviors. Eulerian multi-phase model has been used to simulate the system by using the commercial CFD code ANSYS Fluent 13.0. Gidaspow and Schiller-Neumann drag models have been used to calculate inter-phase drag force. Two-equation standard k-e model has been used to describe the turbulent quantities. CFD simulation of three-phase fluidized bed systems with a distributor plate is not seen in literature. In the present work fluidized bed with distributor having orifice diameter 0.002 m has been studied. Result obtained from the simulation shows that fluidized bed with distributor has higher values of bed expansion and gas holdup compared to that of fluidized bed without distributor plate. It is also observed that in the bed having distributor the velocity magnitudes of solid particles, the liquid and gas phases are high and more fluctuating than in the bed without distributor. Simulation result obtained from CFD simulation with low density solid material is found agree with the experimental finding.
Estrategia didáctica y recursos tecnológicos para la enseñanza de los sistemas de numeración

In 2010 implemented a new Plan of Study Bachelors in Systems Analysis. This plan is formulated on the recommendations established by RedUNCI and standards formulated by the Ministry of Education, as part of the accreditation process that follows the CONEAU. In this setting, the new basic subjects are aimed at deepening the algorithmic concepts of Structured Programming, applying across all content of the course. Then presents the diagnostic analysis which investigates the relevance of the problem to teach classical content of Computer Science, from a computational problem solving by algorithmic design. Is described implementation Diagramar, used for building, debugging and documentation of algorithms from components. It illustrates the methodology used in the chairs by applying it to a case study in the context of numbering systems. The cross-linked algorithmic approach to this and to other contents of the subject seeking to enhance the skills of abstraction in various problem situations own Computer and reuse and adaptation of components to algorithmic design quality in the context of ICT mediated learning.
A temporal analysis of institutional repository research

Due to the vast array of fields that use or have used institutional repositories, and the varying degrees of technology used, it is important to identify the development of the field, institutional repositories, in order to understand the breadth and depth of studies involved. This longitudinal study of the subject terms associated with published journal articles allows for a clearer understanding of the field of institutional repositories as it developed, evolved, and changed over time. This study's uniqueness lies in its longitudinal nature, and its use of information visualization, multidimensional scaling, and parallel coordinate analysis provide information regarding the field of institutional repositories. The multidimensional scaling and parallel coordinate analysis in conjunction with temporal analysis reveal that institutional repositories transitioned through several development phases. Future studies of institutional repositories will most likely discover evaluation tactics and potential guidelines, resulting in a need for additional case studies. Observations from the parallel coordinate analysis reveal three major themes. The first theme is the maturity of institutional repositories as a field over time, the second is the fluctuation and developmental status of institutional repositories until 2010---2013 (Period IV), and the third theme is the emergence of the discipline information science and library science as the strong generator of institutional repository research. Through the visualization and temporal analysis, information was gained regarding the history, development, and future studies within institutional repositories.
5G for smart manufacturing

Today smart manufacturing sector is undergoing a digital transformation addressing the challenge of reducing manual processes and increasing efficiency. 5G is foreseen as key enabler for the future manufacturing ecosystem termed Industry 4.0. 5G-SMART unlocks the value of 5G for smart manufacturing through demonstrating, validating and evaluating its potential in real manufacturing environments. 5G-SMART trials will test the most advanced 5G integrated manufacturing applications such as digital twins, industrial robotics and machine vision based remote operations by bringing first ever 5G deployment in manufacturing setup. 5G-SMART will undertake the evaluation of Electromagnetic compatibility (EMC), channel measurements and co-existence between public and private industrial networks in real manufacturing environments easing the integration of 5G. The new 5G features, developed in 5G-SMART such as time synchronisation and positioning for manufacturing use cases represent a technological leap. 

To further accelerate the take-up of 5G in the manufacturing ecosystem, 5G-SMART will explore new business models, including the roles of mobile network operators. 5G-SMART will result in the development of future 5G standards for the manufacturing sector complemented by new 5G enabled manufacturing products and solutions. 5G-SMART open days will directly address small and medium enterprises making 5G-SMART technology accessible to them. 5G-SMART lead by Ericsson brings together a strong consortium of partners involved in every aspect of the manufacturing ecosystem.
SCanning INNOvation POLicy Impact

All 9 involved SCINNOPOLI partner regions are already fully aware that only the existence and regular application of a impact assessment system will allow a continuous improvement of the need oriented regional innovation policy with the aim to increase the firms’ and regional competitiveness, to create new high quality jobs and thus to increase the regional welfare.

SCINNOPOLI is a Capitalisation Project based on the insights and Good Practices of 4 interregional projects on ‘Regional Innovation Policy Impact Assessment and Benchmarking’ (Specific Support Action “Research and Innovation” activity area, Sixth Framework Programme) and further Good Practices of the partner regions in impact assessment of regional innovation policy. The partnership consists of 9 regions from 8 countries spread over Europe with a good mixture of advanced regions and catching up regions. All partners are involved in the development of their own regional innovation policy as being the
Regional Operational Programme managing authority or an intermediate body with full support of the respective ROP managing authority confirmed by a signed letter of support for SCINNOPOLI.

Therefore, all partner regions will implement/improve their impact scanning activities directly within their Regional Operational Programmes according to the regional action plan which  partners  will jointly develop with the interregional partners with strong involvement of the own managing authority and further stakeholders of its region.

The work programme over 24 months is characterised by an intensive interregional exchange (8 Training Sessions, 9 Study Visits combined with 9 Transfer Workshops, minimum 9 Staff Exchanges, 9 Regional Contact Points) among the partners about the current system of scanning the impact of the regional innovation system as well as about already identified and acknowledged methodologies in monitoring, evaluation and impact assessment.
This approach will facilitate the development of these regional action plans which will be approved by the ROP managing authorities at the end of SCINNOPOLI.

The SCINNOPOLI Recommendations on SCanning INNOvation POLicy Impact will be published at the end of the project summarising the experiences of the partner regions in learning from each other and the joint interregional elaboration of the transfer action plans with the show cases from the 9 partner regions.
The SCINNOPOLI consortium is open for the stakeholders and intermediaries in the partner regions and also to other European regions for further exchange and the dissemination of the SCINNOPOLI results by organising promotion workshops in the partner regions, hosting two conferences with invitation of observer regions, releasing a brochure, 2 newsletters and setting up a website which will remain available for a minimum of five years after the closure of the project.
Violencia laboral por razón de género en el sector agropecuario de Aguascalientes

Objetivo: evaluar la percepción que las trabajadoras del sector agropecuario de Aguascalientes, México, tienen de la violencia de género. Metodología: el estudio es de tipo descriptivo-transversal. Se encuestaron 75 mujeres seleccionadas de acuerdo con el método no probabilístico. Resultados: se obtuvo que 58.67% aseguró haber sido objeto o testigo de algún comentario sexista y 25.33% confirmó haber sido objeto o testigo de acoso sexual (físico o verbal) en su área de trabajo. Limitaciones: el principal obstáculo ha sido la escasez de información empírica y científica sobre estudios de violencia laboral en el sector agropecuario. Otra limitación fue que las encuestas se tuvieron que realizar de manera virtual, debido a las restricciones por la pandemia de COVID-19. Valor: se dan a conocer las desigualdades de género en un sector económico y laboral poco estudiado. Conclusiones: la información presentada demuestra que las trabajadoras detectan la violencia de género en su espacio laboral. Por eso se recomienda hacer cambios en el sector que aseguren equidad de género, seguridad y dignidad humana.
Complexity and classroom learning

This thesis provides a theoretical basis for applying complexity theory to classroom learning. Existing accounts of complexity in social systems fail to adequately situate human understanding within those systems. Human understanding and action is embedded within the complex systems that we inhabit. As such, we cannot achieve a full and accurate representation of those systems. This challenges epistemological positions which characterise learning as a simple mechanistic process, those which see it as approaching a view of the world ‘as it is’ and also positions which see learning as a purely social activity. This thesis develops a materialist position which characterises understandings as emergent from, but not reducible to, the material world. The roles of embodied neural networks as well as our linguistic and symbolic systems are considered in order to develop this materialist position. Context and history are shown to be important within complex systems and allow novel understandings to emerge. Furthermore, shared understandings are seen as emergent from processes of response, replication and manipulation of patterns of behaviour and patterns of association. Thus the complexity of learning is accounted for within a coherent ontological and epistemological framework. The implications of this materialist position for considering classroom learning are expounded. Firstly, our models and descriptions of classrooms are reconciled with the view of our understandings as sophisticated yet incomplete models within complex social systems. Models are characterised as themselves material entities which emerge within social systems and may go on to influence behaviour. Secondly, contemporary accounts of learning as the conceptual representation of the world are challenged.
Uncaught signal imputation for accuracy enhancement of WLAN-based positioning systems

In this paper we propose a technique to enhance the accuracy of WiFi fingerprint-based localization by imputing uncaught access point (AP) signals of WiFi fingerprints. Two techniques were developed for this; one is to impute uncaught AP signals by referring to WiFi radio map (WRM) fingerprints at the very previous location, another is referring to WRM fingerprints obtained by predicting the next location. When we measured the accuracy of localization at an E-Mart, Seoul, Korea and a KAIST Library, Daejeon, Korea with and without uncaught signal imputation, the imputed signal resulted in around 30% better accuracy improvement than the signals without imputation. In addition, the imputation methods using WRM information showed significantly better accuracy than using a fixed value for uncaught AP signals. This indicates that the uncaught signal imputation, which was overlooked in the WLAN-based localization, should be incorporated with other filtering techniques for a more reliable and accurate localization.
Expert Network on Textile Recycling

ENTeR focuses on waste reduction to prevent depletion of non-renewable resources in the textile industry. It will strengthen the innovation capacity of textile companies in central Europe, improve sustainable links among industrial textile areas and foster closer cooperation on waste management and circular economy._x000D_
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The project partners are located in five central European countries with a relevant presence of the textile industry and with a national textile platform each. The project aims to accelerate cooperation between the involved textile territories, promoting a joint offer of innovative services by the main local research centres and business associations (‘Virtual Centre’). It will also involve public stakeholders in defining a strategic agenda and related action plan to drive circular economy considerations and actions._x000D_
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The approach of the project is oriented to the management and optimisation of waste, in a life cycle design (or eco design) perspective. The aim is to demonstrate the benefit of an operational collaborative model amongst research and business partners, based on an online tool and shared skills focused on waste eco design and resource efficiency._x000D_
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Information added on 2020-05-18, regarding the mitigation of the effects of COVID-19 (the coronavirus pandemic that started in 2019) (English language only): The dramatic increase in the need for single-use masks by the population produces a new waste stream for which the recycling potential is unknown. ENTeR partners apply their knowledge to this textile waste in their new pilot. They analyse possible sorting methods, dismantling procedures, cleaning treatments, and recycling processes to minimise the loss of non-renewable resources. As a result, a set of guidelines and best practices will fill this knowledge gap for local authorities, allowing them to adopt sustainable waste management models.
Microwave-assisted green synthesis of silver nanoparticles and the study on catalytic activity in the degradation of dyes

Abstract Biogenic methods are considered to be a safer alternative to usual physical and chemical methods of nanosynthesis due to their environment friendly nature and cost effectiveness. One major shortcoming of biological methods is their characteristically slow nature. In this study, we report a novel microwave-assisted green method for the rapid synthesis of silver nanoparticles. We synthesized silver nanoparticles by microwave irradiation using the leaf extract of Biophytum sensitivum as both the reducing and stabilizing agent. The nanoparticles are characterized by UV–vis, FTIR, XRD and HR-TEM studies. The FTIR spectrum provides sufficient evidences for the involvement of phytochemicals in stabilizing the nanoparticles. The XRD and HR-TEM studies clearly demonstrate the crystalline nature of the nanoparticles. From the TEM images, the silver nanoparticles are found to be almost spherical with an average diameter of 19.06 nm. The synthesized silver nanoparticles have been successfully applied as a catalyst in the degradation of methyl orange and methylene blue by NaBH4.