SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Dissecting the interplay between the dynamics of immune responses and pathogen proliferation in vivo

Pathogen proliferation has profound implications for its persistence, treatment strategies, and the induction and execution of protective immune responses. In vivo, pathogen proliferation rates are heterogenic, confronting the immune system with a variety of microbial physiological states. It is unknown if, and by what molecular mechanism, the immune response can distinguish these different states on a cellular level. Also, understanding the link between pathogen proliferation and immune cell dynamics could provide critical information on how infections can be controlled, and how to counteract pathogen persistence and antibiotic resistance. However, this question has never been addressed due to difficulties in studying the dynamics of immune cells and at the same time probing pathogen proliferation.
In this project, we will make use of a novel in vivo reporter system that I have developed, in order to determine the role of the pathogen's proliferation for its interaction with the immune system. Specifically, we will (1) determine the tissue niche in which the pathogen proliferates, (2) investigate the differential dynamics of phagocyte-pathogen- and of T cell-APC-interactions related to pathogen proliferation rate, (3) manipulate the relationship between pathogen proliferation and immune cell dynamics by using proliferation-deficient mutants and optogenetic pathogen inactivation, (4) identify signaling pathways that are differentially induced in cells infected by high versus low proliferating pathogens, and test their involvement in differential immune cell dynamics related to pathogen proliferation.
ImmProDynamics will for the first time provide insights into how cells of the immune system react to distinct pathogen proliferative states in vivo. This will greatly expand our knowledge of host-pathogen interactions, which will be critical for the design of efficient vaccines and antimicrobial therapy.
O primeiro lactário de Lisboa

N'uma epoca em que o principio da solidariedade social começa a ser comprehendido e a fructificar grandemente, a creação de uma obra destinada a beneficiar aquelles que dos beneficios da sociedade mais precisam -as creançasnão podia deixar de encontrar o mais largo auxilio."(Associação Protectora…, 1903, p. 3-4).No início do século XX, tal como em outros países europeus, também em Portugal a elite esclarecida e culta demonstrava uma sensibilidade social crescente face às dificuldades vividas pela maioria da população, sobretudo nas grandes cidades.O apoio e proteção à primeira infância, e às crianças, constituem uma preocupação partilhada sobretudo por médicos, higienistas, políticos e beneméritos.Preconizando os princípios fundamentais do positivismo, pretendiam afirmar nestes domínios valores de progresso científico e social que, frequentemente, se traduziam no apoio financeiro e/ou especializado a equipamentos existentes ou, ainda, dinamizando e viabilizando a sua construção.A pobreza atingia quem trabalhava, devido aos baixos salários e à escassez de apoios sociais, agudizando a fome, favorecendo a mendicidade e a proliferação de bairros precários e insalubres.Os fluxos migratórios para as cidades, sobretudo Lisboa e Porto, tiveram implicações diretas na imagem de ambas as urbes que, paulatinamente, foram perdendo marcas de uma ruralidade até então predominante, e geraram assimetrias que desde o início do século XX se foram acentuando numa tripla dimensão: urbana, socioeconómica e
В кармане у подпольного парадоксалиста

For many years, the F. Dostoyevsky researchers have been arguing about the function of money in the writer’s works. The majority of the Dostoyevsky specialists maintain that, even though the material issue remains urgent in all Dostoevsky’s works, it does not determine the characters’ attitudes and behavior. In order to refute this conventional opinion, the authors of the article have applied some of the most important aspects (Production, Internal Circulation, Metatheoretical) of the New Economic Criticism, a new method of literary analysis, originated a few decades ago in the United States, and also discuss various aspects of money as the economic category of Dostoyevsky’s works. The article is focused on the Notes from Underground, one of the most important novels of Dostoyevsky, written in the full swing of the incipient yet extensive reforms of the mid-19th century Russia. The article seeks to demonstrate that the economic practices of the main character not only determine the entire course of the story, but also reflect the essential principles of the Russian economic system functioning and its further change as well as help to reveal the meanings of the text no longer being recognized today.
AID TO NEW ENTERPRISES FOR THE ACQUISITION OF SERVICES IN THE GREEN AND BLUE ECONOMY SECTORS RELATED TO THE SUSTAINABLE TOURISM CHAIN ​​FOR THE ENTREPRENEURIAL DEVELOPMENT OF MARGINAL TERRITORIES OF THE COOPERATION AREA

The SINTURS project faces the territorial challenge of consolidating the entrepreneurial development of marginal areas through a structured intervention to help newly established or innovative companies in the sustainable tourism supply chain. During the first part of the project, after providing services to companies in Liguria and PACA, a methodology will be developed that will be tested during the last part of the project in the other similar cross-border areas of Sardinia, PACA and Liguria. The project will enhance the results achieved by the Art Lab Net project (1st Call of the PO Marittimo 14-20) using three of the centres created (resource centres for innovation in artistic craftsmanship). During the project, also having the companies involved in the Art Lab Net project as a point of reference and making use of procedures open to public scrutiny, the companies will be selected and the suppliers of cross-border services will be identified. The characteristics of the services are suitable for two different categories: shared solutions (e.g.,an innovative service platform to accelerate and incubate businesses) and solutions designed “jointly” (e.g., marketing plans, communication campaigns via social media, etc.).  SINTURS refers with varying levels of intensity to public and private targets (new and innovative companies, suppliers, public stakeholders, industry and trade associations, the population), with targeted and specific actions being launched to reach them effectively.
 The partnership is limited to effectively and efficiently addressing the problem that has been identified. The four public partners all boast significant experience in cross-border European planning to support existing businesses and in support activities for the development of new businesses. For a long time now, IRU and CMAR PACA have also been involved in business creation programmes aimed at young people, the long-term unemployed and NEETs.
FRancia Italia START2 - The specialized services of the network of cross-border incubators in the space of the Maritime OP

The experience developed as part of the FRI_Start project forms the basis for this project. FRI_Start created a network of incubators (six operators covering all the Programme territories) with ‘Quality Label Marittime IT_FR’ certification, which will now form the basis of a fertile context to establish innovative, cross-border start-ups that are able to firmly position themselves in the area, favouring a focus on innovation and cross-border and global collaboration. The aim is to provide the selected start-ups with a series of specialised services, chosen from among the services tested with the first project; these services will be in addition to the standard ones provided by the incubators. This specialist assistance will be dedicated to key aspects (IPR, digitalisation, seed and early stage financing, risk finance, identification of foreign markets/customers, etc.) and will be integrated with a series of business opportunities (trade fairs, mobility). The PO Marittimo area constitutes an ecosystem with average dynamics in terms of innovation (EU reports classify France as an Innovation Follower and Italy as a Modest Innovator); in order to achieve growth, new common/shared policies are needed among innovation facilitators, to improve the innovative standards of start-ups and SMEs (92% of companies in the area) and make them more competitive on the global market. The project will be implemented by a cross-border partnership made up of important players in terms of innovation/business creation and will extend to companies across the entire PO Marittimo area, based on the collaborations established when the Fristart incubator network was set up (this network is open to new incubators that wish to join). The level of competitiveness achieved by the start-ups being supported with specialised services will be tested at the end of the project, through a cross-border business plan competition.
Formal frameworks for modal notions conceived as predicates

Philosophy strives for a better understanding of modal notions such as necessity, possibility, truth, knowledge. Modal logic, however, the formal tool privileged by philosophers to shape their theories about intensional notions, displays severe drawbacks: its use determines an incoherent treatment of different kinds of modalities and it is expressively weak as important general claims are not fully formalizable in it. In the project I develop an alternative approach to modal notions. Instead of treating them as operators applying to formulas, I will consider them as predicates applying to terms naming formulas. The overarching aim of the proposal is to provide philosophy with an expressive and coherent framework that could represent a valid alternative to modal logic. More precisely, I will develop three research objectives corresponding to three fundamental research gaps traceable in the current literature on modal predicates: the formulation of a natural account of the bearers of modal notions, a consistent and mathematically powerful treatment of the interaction of modal predicates, a predicate approach to de re modal ascriptions that will open the way for a new approach to modal metaphysics in the predicate setting. The project will develop a unified effort to bridge mathematical logic, philosophy of mathematics and metaphysics. It will result in the establishment of leading research profile setting the agenda for a network of researchers in the flourishing area of mathematical philosophy.
Variations of geomagnetic cutoff rigidity in the southern hemisphere close to 70°W (South-Atlantic Anomaly and Antarctic zones) in the period 1975–2010

Abstract We report the existence of rapid variations in (effective) geomagnetic cutoff rigidity (Rc) between the equatorial and Antarctic zones adjacent to the Andes Mountains, revealed by the variation rate of geomagnetic cutoff rigidity (VRc) in the period 1975–2010. Our analysis is based on empirical records and theoretical models of the variations in cosmic rays and on the structure of geomagnetic fields. These have given us a different view of variations in Rc in time and space along the 70°W meridian, where secular variations in the geomagnetic field are strongly influenced by the proximity of the South Atlantic Magnetic Anomaly (SAMA), one of the most important characteristics of the terrestrial magnetic field that affects our planet, close from the equator to the 50°S parallel and from South America to South Africa. The VRc presents rapid changes in mid-latitudes where SAMA exerts its influence despite the existence of smooth changes in the geomagnetic field. This shows that these changes occur mainly in the spatial configuration, rather than in the temporal evolution of Rc. The analysis was performed using measurements from the Chilean Network of Cosmic Rays and Geomagnetism Observatories, equipped with BF-3 and latest generation He-3 neutron monitors, Fluxgate magnetometers, geomagnetic reference field (IGRF) and Tsyganenko 2001 model (just for completeness).
Study on primary productivity and secondary production of artificial structures next to the S. Croce seabed bulge

The study, a continuation of the research put in place under Programme INTERREG IIA/Phare-CBC Italy- Slovenia, aims at the characterization of the S. Croce seabed bulge site through the recording - by means of multiparameter probes - and the chemical analysis of the main parameters and factors that condition the biotic component, such as temperature, salinity, dissolved oxygen and transparency. Another stage concerns the analysis of biodiversity (number of species and respective abundance) and the ascertainment of maturity of the immersed structures according to the thigmotropic effects produced by the barrier on fish. The biomasses of species that are commercially interesting (mussels, oysters and cockles) are assessed in order to “weigh” their potential economic exploitation and to ascertain the effect of captation and passive repopulation produced by the Multilevel Underwater Structures (Ml.U.S.). An analysis of colonization dynamics is carried out with reference to the different types of substrate and the effects of experimenting innovative techniques for the restoration of the environment and the marine ecosystem. As regards the characterization of the bottom biocenosis and the thanatocenosis that are observed around the seabed bulge, research is carried out for an impact assessment of the artificial structure on the environment and the potential changes produced by the colonizing organisms on the surrounding sediments. Lastly, the existing structures are adjusted by parcelling the available space in order to widen the range of habitats for each size of fish; moreover, a surveillance service is envisaged, to prevent sport fishing in the area. At the end of the project, the results of the theoretical and applied research will be used for educational purposes, both on paper and multimedia supports.
Can i see quantum gravity?

The interplay between two of the most important building blocks of nature, quantum mechanics and gravity, has been a great source of inspiration for theoretical physics, leading to discoveries such as the Hawking radiation of black holes and the development of string theory. In turn, the following picture emerged: physics at the most fundamental level is governed by the rules of quantum mechanics while gravity is some effective coarse-grained description of the underlying microscopic theory. Given that the microscopic degrees of freedom are non-local, standard techniques such as the renormalization group and effective field theory a priori do not apply. Nevertheless, we use effective field theories that incorporate general relativity to describe our observations.

With the discovery of gravitational waves and the various ongoing and upcoming experiments that will put general relativity to the test, it has become urgent to assess the validity of the standard framework of effective field theory for describing observable quantum gravity effects. Recent developments in resolving the information loss paradox and the quantum nature of black holes concluded that effective field theory must be modified in a way that uniquely incorporates quantum gravity. The main purpose of this proposal is to describe this modification in a precise and quantitative way, ultimately connecting it to potential experimental discoveries.

In order to achieve this goal, I will approach the problem using a combination of thermodynamics, hydrodynamics and quantum information theory, mostly in the context of the AdS/CFT correspondence, where a precise description of quantum gravity is available. As a by-product of identifying observational features of quantum gravity, I will also make substantial progress in several foundational problems. My broad track record and expertise, and the fact that I have already obtained promising preliminary results, makes me uniquely qualified to lead this endeavor.
Where silicon valley meets silicon prairie: exploring the research and development of digital farming technologies

This research aims to understand how, by whom, and with what intentions and objectives digital farming technologies are being developed, and what this means for the future of food production. Digital innovations in agriculture have attracted much interest in recent years, and are often touted as the solution to feed the world with less resources, inputs, pesticides, human labour, and detrimental environmental impacts than the current food system. At this point, however, it is unclear whether digital farming technologies will indeed fulfil such promises. This research project presumes that digital farming technologies need to be studied at their initial research and development levels – to fully understand the various motivations, goals, practices, and decisions made during these early, but critical, stages of technological development – and therefore the products that will come to market. Long before technologies arrive at the farm, various actors – scientists, technology developers, engineers, Start-Up entrepreneurs, ‘urban hipsters’, financiers, and business leaders – begin to imagine, develop, and make key decisions concerning the future use of technologies. Understanding these initial stages of development will allow us to gauge how these processes determine how, by whom, and under what conditions digital farming technologies will be used in society. This research will be done by undertaking participant observation and qualitative interviews within two of the most expansive and innovative clusters of agricultural technology development in the world, the University of California (UC) system, coupled with Silicon and Central Valleys in the US; and Wageningen University & Research (WUR), with Food Valley, in the Netherlands. Within these sites, I focus on two major funding structures and entrepreneurial cultures, university-based Public Private Partnerships (PPPs), and finance-capital funded Agtech Start-Ups to draw my larger conclusions.
Mind the last spike — firing rate models for mesoscopic populations of spiking neurons

The dominant modeling framework for understanding cortical computations are heuristic firing rate models. Despite their success, these models fall short to capture spike synchronization effects, to link to biophysical parameters and to describe finite-size fluctuations. In this opinion article, we propose that the refractory density method (RDM), also known as age-structured population dynamics or quasi-renewal theory, yields a powerful theoretical framework to build rate-based models for mesoscopic neural populations from realistic neuron dynamics at the microscopic level. We review recent advances achieved by the RDM to obtain efficient population density equations for networks of generalized integrate-and-fire (GIF) neurons - a class of neuron models that has been successfully fitted to various cell types. The theory not only predicts the nonstationary dynamics of large populations of neurons but also permits an extension to finite-size populations and a systematic reduction to low-dimensional rate dynamics. The new types of rate models will allow a re-examination of models of cortical computations under biological constraints.
Safety device having pivoting member preventing doors from slamming

The mechanism includes a board 20, an arm rotatably attached at a first end 26 to board 20 by pivot 28. A door arresting wedge 25 attached perpendicularly to the other end of the arm 26 away from pivot 28. At least one magnet 49 disposed on the board 20 for attracting arm 26. At least one magnet 30 disposed on an edge of the arm, and at least one stopper means to limit the rotation of the arm 37, 46, 48. When a door is shut is excessive force the centrifugal force causes arm 26 to swing outward and extend beyond the periphery of the door edge and engages the door frame preventing the door from fully closing; thus avoiding injuries from trapped hands or fingers. Stopper 37 may be adjustable to alter the centrifugal force required to overcome the grip of the stopper. A flexible buffer (72, fig.3C, 3D) may be provided which automatically urges the door arresting projection 25 back to its initial retracted starting position. A second door arrestor may be provided retained in initial retracted position by engagement with the first door arrestor and urged into an extended position by a spring (figure 4A, 4B). The anti-slamming device may be mounted on the surface of a door or within the door, particularly within a vehicle door.
MERANET- CHAMADA 2019- SMARTMATTER-ANÁLISE BIOQUÍMICA CENTRAL S.A.S.

DESENVOLVIMENTO DE NANOFILMES POLIMÉRICOS INTELIGENTES QUE CONTENHAM NANOPARTÍCULAS FUNCIONAIS, TAIS COMO METAMATERIAIS FUNCIONAIS COM COMPORTAMENTO ÓTICO DE CONDUÇÃO MODULADO POR INTERAÇÕES ESPECÍFICAS COM ANALITOS-ALVO.
Design, synthesis, and biological evaluation of 2-(phenoxyaryl)-3-urea derivatives as novel P2Y1 receptor antagonists

A novel series of 2-(phenoxyaryl)-3-urea derivatives were designed, synthesized, and biologically evaluated for their anti-thrombotic activity. Most of compounds exhibited good inhibition against P2Y1 receptor. Among them, three compounds 11, 12, and 13 demonstrated good P2Y1 receptor antagonistic potency in vitro (IC50 = 0.62 μM, 0.82 μM, and 0.21 μM, respectively). In antiplatelet aggregation study, four compounds 2, 3, 9, and 13 showed good antiplatelet activity. The possible binding modes of compounds with P2Y1 receptor were also explored by molecular docking simulation. The docking studies demonstrated that compound 13 interacted well with Phe119 through hydrophobic interaction and modestly improved the P2Y1 receptor antagonistic activity, making it justifiable for further investigation.
Monitoramento de vespas galhadoras em viveiro florestal

As plantações florestais com espécies e clones de Eucalyptus no Brasil tem crescido muito e o aumento de ocorrência de pragas também, principalmente as pragas exóticas. Dentre essas, as vespas-de-galha Leptocybe invasa (Hymenoptera: Eulophidae) foi detectada no Brasil em 2008 e Ophelimus maskelli (Hymenoptera: Eulophidae) em 2020, sendo L. invasa formadora de galhas no pecíolo e nervura central de folhas, ramos novos e ponteiros e O. maskelli na região do limbo foliar. Essas galhas resultam na interferência no transporte de nutrientes das folhas, causando senescência precoce das mesmas. O controle biológico é realizado pelos parasitoides Selitrichodes neseri e Quadrastichus mendeli (Hymenoptera: Eulophidae) para L. invasa e o parasitoide Closterocerus chamaeleon (Hymenoptera: Eulophidae) para O. maskelli. Devido a tal importância desses insetos-praga, o trabalho teve por objetivo monitorar as vespas galhadoras L. invasa e O. maskelli e seus parasitoides em viveiro florestal. O monitoramento foi realizado no viveiro florestal localizado no munícipio de Piracicaba, SP, com uso de armadilhas amarelas adesivas de coloração amarela, instalado em quatro pontos do viveiro. O monitoramento foi realizado mensalmente de junho de 2020 a janeiro de 2022. As armadilhas foram avaliadas com uso de microscópio esteroscópico contando o número de adultos das espécies-praga e seus inimigos naturais. Os meses sem a ocorrência de vespas galhadoras e seus parasitoides foi em agosto de 2021 e janeiro de 2022. Os períodos de maior ocorrência das vespas galhadoras e seus parasitoides foi entre setembro de 2020 a janeiro de 2021 e entre abril a julho de 2021. Os picos populacionais das vespas ocorreram em abril de 2021 para L. invasa, em dezembro de 2020 para Q. mendeli, em setembro 2020 e abril de 2021 para S. neseri, em setembro de 2021 para O. maskelli e em julho de 2021 para C. chamaeleon. Os resultados obtidos serão importantes para tomadas de decisões no manejo integrado das vespas galhadoras em viveiros do eucalipto.