SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Elucidating transcriptional rewiring on hematological malignancies via computational methods

Genes and their corresponding pathways form networks that regulate various cellular functions that are critical in tumor development. These networks, coined Gene Regulatory Networks (GRNs), define the regulatory relationships among genes and provide a concise representation of the transcriptional regulatory landscape of the cell. Further, different phenotypes can lead to activation of different functional pathways by different global rewiring of the underlying GRNs. To uncover such transcriptional rewiring, in this project I will further advance and optimize a recent efficient computational method developed by myself, coined LINKER,  aiming at uncovering GRNs from RNAseq data; and given those networks, develop efficient differential network analysis methods that will shed light into the regulatory rewiring associated with phenotype. As one of the key goals of this proposal is the translation of computational methods to advance clinical cancer knowledge, I will work with the hosting group to apply LINKER to uncover the transcriptional rewiring associated to hematological malignancies. Specifically, I will apply LINKER in a stepwise model first on available RNA-seq data from multiple myeloma and acute myeloblastic leukemia, and second to primary data from patients with these diseases provided by the hosting supervisor. Rewired GRNs between MM and normal BM plasma cells and between leukemic blast and normal hematopoietic progenitor cells, potentially implicated in the pathogenesis of the disease, will be functionally validated by state of the art gain and loss of function technologies (CRISPR/cas9). As data provided by the host institution includes clinical follow up from patients we will also examine the prognostic value of our identified GRN.  I envision that LINKER will provide additional novel insights to our understanding of the key rewiring associated with these malignancies, increased by our ability to translate the discovered biomarkers to patient treatment.
Evapotranspiration Trend and Its Relationship with Precipitation over the Loess Plateau during the Last Three Decades

There have been few studies conducted on the changes in actual ET over the Loess Plateau, due to the lack of reliable ET data. Based on ET data simulated by the Community Land Model, the present study analyzed the changes in ET over the Loess Plateau. The results showed the domain-average ET to have decreased in the past 31 years, at a rate of 0.78 mm year −1 . ET fluctuated much more strongly in the 1990s than in the 1980s and 2000s, and, apart from in autumn, ET decreased in all seasons. In particular, ET in summer comprised about half of the annual ET trend and had the sharpest trend, dominating the interannual decline. ET also decreased more sharply in the semiarid than semihumid regions. The declining trend of ET was attributed to declining precipitation and air humidity. Locally, the ET trend was closely related to local mean annual precipitation: in areas with precipitation less than 400 mm, ET showed a decreasing trend; in areas with precipitation larger than 600 mm, ET showed an increasing trend; and in areas with precipitation in the range of 400–600 mm could be classified as a transitional zone.
Acrylic polymers derived from high solid emulsions as excipients to pharmaceutical applications: synthesis and characterization

Novel polymeric excipients need to be designed to allow for the controlled delivery of many drugs to treat a variety of diseases. In this work, two polymers based on different proportions of ethyl acrylate, methyl methacrylate, and butyl methacrylate were synthesized by multistage emulsion polymerization using a redox initiator system to yield excipients for the manufacture of prolonged release tablets by the coating or compression technique. Fourier Transform Infrared spectrometer (FTIR) indicated that the polymerization reaction of the monomers was complete without carbon double bond absorption bands. Differential Scanning Calorimetry (DSC) analysis indicated that the glass transition temperature (T
 g) of the polymers was around 50 °C. The dispersions obtained were characterized in terms of particle size and particle size distribution (PSD) using Dynamic Light Scattering (DLS), and the particle charge (zeta potential) was measured by electrophoretic mobility. The measurements showed particle diameters of approximately 200 nm and a zeta potential close to −60 mV. The low viscosity obtained for the polymers was attributed to bimodal PSD. The dispersions were freeze dried and the particles were submitted to in vitro cell tests to make a preliminary check of the toxicity of the materials. The low viscosity of the polymers, the absence of volatile solvents, and the high solid content (>50%) are ideal for these polymers to be used as coatings and matrices pharmaceutical excipients for prolonged release tablets. In vitro MTT tests suggested that the materials can be considered nontoxic.
Fracture mechanics testing of irradiated rpv steels by means of sub-sized specimens (fractesus)

Fracture mechanics testing of irradiated RPV steels by means of sub-sized specimens (FRACTESUS).

The European Union has defined clear short and long term objectives to achieve its energy transition towards sustainable energy and climate neutral economy by 2050. The success of this transition relies on the combination of energy efficiency and low carbon energy in all sectors of the economy. In particular, the industry and transport sector will need to rely more heavily on electricity to achieve this goal.  In all electricity mix scenarios up to 2050, one needs to rely on one or a combination of existing nuclear power plants, long term operation, new nuclear build and future nuclear systems. Safety and operability of any nuclear systems heavily relies on a defense in depth strategy where the integrity of structural material plays an essential role. Due to material availability and/or irradiation constraints, the use of small size specimen to obtain reliable measurement of the resistance to fracture is needed by the nuclear industry to comply with the amended Nuclear Safety Directive. Small size specimen fracture toughness measurement has already been shown possible. However, some effort is still requested to achieve European regulatory acceptance of this approach. The goal of this project is to join European and International effort to establish the foundation of small specimen fracture toughness validation and demonstration to achieve change in code and standards allowing to address the various national regulatory authority concerns.  FRACTESUS is involving in a very early stage regulatory bodies, code and standardization committee, the industry and the international community in order for the consortium to optimize available resources and expertise.
Advanced Glycation End Products and Acute Myocardial Infarction

The aim of this study was to analyse the dynamics of advanced glycation end products (AGEs) after acute myocardial infarction (MI).Blood samples were taken from 20 non-diabetic patients with acute MI on the 1st, 2nd, 3rd and 5th day after the onset of symptoms. Serum AGE levels were estimated spectrofluorometrically.A marked decrease in the AGE-specific fluorescence was observed, especially between the 1st and the 2nd days after MI.The findings of this study tend to contradict the suggestion that AGEs are relatively stable markers of carbonyl stress. Although the reason for this is currently unknown, this observation may have implications for ongoing studies of AGEs in cardiovascular diseases.
Las variaciones Dippel. Aria constitucional con cuarenta y tres cánones

Recensión de Horst Dippel, Moderner Konstitutionalismus. Entstehung und Ausprägungen. England – Nordamerika – Frankreich – Deutschland – Europa / Europäische Union – Lateinamerika. Schriften zur Verfassungsgeschichte. Band 88. Duncker &amp; Humblot, Berlín, 2021. 848 pp. Enviado el (Submission Date): 24 de abril de 2022Aceptado el (Acceptance Date): 1 de mayo de 2022
Novelties, biases, and landscapes in evolution

Several challenges undermine our ability to predict the course of evolution: the likelihood of evolutionary novelties, the impact of the adaptive landscape, and the influence of developmental biases. NOBLE (NOvelties, Biases, and Landscapes in Evolution) will make use of cutting-edge machine learning, fossil times series, and biomechanical modelling to generate a synthesis of the predictability of phenotypic evolution.  

First, NOBLE will use ancestral state reconstruction to determine if origination of and loss of novelties are predictable over macroevolutionary timescales (>113 million years).  Trait origination may be predictable from ancestral morphology, while degree of trait specialization may predict loss. 

Next,NOBLE will investigate whether convergent evolution is a product of adaptation (as is so often assumed) or chance (rendering it less predictable).  This phase will quantify the magnitude and frequency of morphological convergence between functionally and structurally homologous traits in different lineages. Then, observed convergence will be compared to converge achieved in simulations of Brownian motion (and biased random walks over biomechanically-derived adaptive landscapes.

Finally, NOBLE will determine the impact of integration between traits on 1) the strength of within-trait developmental biases and 2) morphological diversity. This is possible because NOBLE’s model organism, cheilostome bryozoans, have a rich fossil record and a colonial growth form – allowing within-genotype, within-population phenotypic variation to be quantified. The influence of trait integration will be examined at five levels of comparison (from within a single species to across multiple clades).

Not only will NOBLE begin untangling the Gordian Knot of evolutionary predictability, it will provide an emerging researcher with an advanced statistical skillset (incorporating phylogenetic and paleontological analyses).
Development of Daszer s.c. through a design audit completed by a design strategy.

As part of the audit, actions will be carried out to lead to the analysis of the company, and this will contribute to the creation of a design strategy. The activities to be carried out as part of the audit are: — design analysis which consists of analysing product offer, business model, technology, organizational structure, communication processes, marketing strategy and defining and characterising customers, competition, key industry trends. The experts assigned to this action are: Zbigniew Chmielewski, Wojciech Klęsk, Paweł Wacnik After the analysis, a design strategy will be created. The experts assigned to the strategy are: Zbigniew Chmielewski, Paweł Wacnik. The audit will cover 1-3 months, while the fourth month of the strategy, i.e. 30 days, will be built. The project aims to help the company make new, key decisions related to the design process.
Crystal structure of DszC from Rhodococcus sp. XP at 1.79 Å

The dibenzothiophene (DBT) monooxygenase DszC, which is the key initiating enzyme in "4S" metabolic pathway, catalyzes sequential sulphoxidation reaction of DBT to DBT sulfoxide (DBTO), then DBT sulfone (DBTO2). Here, we report the crystal structure of DszC from Rhodococcus sp. XP at 1.79 Å. Intriguingly, two distinct conformations occur in the flexible lid loops adjacent to the active site (residue 280-295, between α9 and α10). They are named "open"' and "closed" state respectively, and might show the status of the free and ligand-bound DszC. The molecular docking results suggest that the reduced FMN reacts with an oxygen molecule at C4a position of the isoalloxazine ring, producing the C4a-(hydro)peroxyflavin intermediate which is stabilized by H391 and S163. H391 may contribute to the formation of the C4a-(hydro)peroxyflavin by acting as a proton donor to the proximal peroxy oxygen, and it might also be involved in the protonation process of the C4a-(hydro)xyflavin. Site-directed mutagenesis study shows that mutations in the residues involved either in catalysis or in flavin or substrate-binding result in a complete loss of enzyme activity, suggesting that the accurate positions of flavin and substrate are crucial for the enzyme activity.
High-Quality energy performance assessment and certification in europe accelerating deep energy renovation (qualdeepc)

The QualDeEPC project is aiming to both improve quality and cross-EU convergence of Ener-gy Performance Certificate (EPC) schemes, and the link between EPCs and deep renovation: High-quality Energy Performance Assessment and Certification in Europe Accelerating Deep Energy Renovation (QualDeEPC). The objective of the project is to improve the practical implementation of the assessment, is-suance, design, and use of EPCs as well as their renovation recommendations, in the partici-pating countries and beyond. Recommendations for renovation shall be made coherent with deep energy renovation towards a nearly-zero energy building stock by 2050. In order to reach these objectives, the project will organise its activities in four stages: 1 | Analysis of existing EPC schemes, good practice, shortcomings, and priorities for improvement 2 | Development and testing of concrete proposals and tools for enhanced EPC assessment, certifi-cation, and verification, as well as Deep Renovation Network Platforms 3 | Adaptation to country needs and implementation of consensus elements, and developing a roadmap for further dialogue and  4 | Sustainability Strategy and Conclusive policy recommendations, dialogue, and transfer. Project partners will work to achieve consensus and implementation during the project for as many improvements as possible, seeking the cooperation of certification bodies, energy agen-cies and other organisations. Some of these are project partners, many others agreed to sup-port the project as associated partners. However, many of the potential improvements to EPC assessment, certification, and independent monitoring and verification will need adaptation of standards, regulations, or even legislation. The QualDeEPC project will stimulate such changes by (1) intensive dialogue involving the important stakeholders at all levels from the very beginning in the above four project stages and (2) disseminating its findings among the relevant target audiences in Europe.
CANIBEXIDENTIFY VARIATIONS IN THE GALACTIC ENVIRONMENT OF THE SUN USING ENERGETIC NEUTRAL ATOMS?

The Interstellar Boundary Explorer (IBEX) spacecraft is providing the first all-sky maps of the energetic neutral atoms (ENAs) produced by charge-exchange between interstellar neutral \HI\ atoms and heliospheric solar wind and pickup ions in the heliosphere boundary regions. The 'edge' of the interstellar cloud presently surrounding the heliosphere extends less than 0.1 pc in the upwind direction, terminating at an unknown distance, indicating that the outer boundary conditions of the heliosphere could change during the lifetime of the IBEX satellite. Using reasonable values for future outer heliosphere boundary conditions, ENA fluxes are predicted for one possible source of ENAs coming from outside of the heliopause. The ENA production simulations use three-dimensional MHD plasma models of the heliosphere that include a kinetic description of neutrals and a Lorentzian distribution for ions. Based on this ENA production model, it is then shown that the sensitivities of the IBEX 1.1 keV skymaps are sufficient to detect the variations in ENA fluxes that are expected to accompany the solar transition into the next upwind cloud. Approximately 20% of the IBEX 1.1 keV pixels appear capable of detecting the predicted model differences at the $ 3 \sigma$ level, with these pixels concentrated in the Ribbon region. Regardless of the detailed ENA production model, the success of the modeled \BdotR\ directions in reproducing the Ribbon locus, together with our results, indicate that the Ribbon phenomenon traces the variations in the heliosphere distortion caused by the relative pressures of the interstellar magnetic and gaseous components.
Active & intelligent packaging materials and display cases as a tool for preventive conservation of cultural heritage.

Most Cultural Heritage objects housed by museums are often stored under unsuitable climate conditions. APACHE will develop a cutting edge technology to control and prevent the degradation of such patrimony. The novel approach is based on three pillars: 1) advanced sensing and absorbing materials to control the artifacts’ environment; 2) modeling to define the threshold of artifacts’ degradation and to discriminate between the need for preventive or remedial conservation; 3) remote control of the works of art stressors. The unique combination of these pillars will reduce to the lowest possible level the costs actually required by conventional technology for art conservation. New generation of active and intelligent display cases, crates, and storage boxes, will be implemented thanks to: i) The unique APACHE partnership, comprising the most important experts in the three aforementioned pillars; ii) The development of easy-to-use sensing devices able to communicate through Wireless Sensor Networks and Radio Frequency Identification Devices thanks to Industry 4.0-5.0 ICT technologies, granting the optimal environmental conditions around the art objects. Multiscale models integrated in an open simulation environment will be used to predict the degradation of artefacts and set the properties of sensors (detection limits) and polyfunctional absorbents. APACHE includes small, medium, and large museums exhibiting representative variety of display and storage conditions. For instance, the Venice Peggy Guggenheim Collection features one of the most important collections of modern/contemporary art, which experiences highly unfavorable environmental conditions, difficult to control with conventional tools. Centre Pompidou and National Museum of Hungary possess a vast amount of artefacts stored in deposits (e.g. in crates and boxes). Moreover, a decision-making tool composed by a modular set of decision trees will be offered to end-users to guide them through the best solutions.
Mitochondrial Apoptosis and FAK Signaling Disruption by a Novel Histone Deacetylase Inhibitor, HTPB, in Antitumor and Antimetastatic Mouse Models

Compound targeting histone deacetylase (HDAC) represents a new era in molecular cancer therapeutics. However, effective HDAC inhibitors for the treatment of solid tumors remain to be developed.Here, we propose a novel HDAC inhibitor, N-Hydroxy-4-(4-phenylbutyryl-amino) benzamide (HTPB), as a potential chemotherapeutic drug for solid tumors. The HDAC inhibition of HTPB was confirmed using HDAC activity assay. The antiproliferative and anti-migratory mechanisms of HTPB were investigated by cell proliferation, flow cytometry, DNA ladder, caspase activity, Rho activity, F-actin polymerization, and gelatin-zymography for matrix metalloproteinases (MMPs). Mice with tumor xenograft and experimental metastasis model were used to evaluate effects on tumor growth and metastasis. Our results indicated that HTPB was a pan-HDAC inhibitor in suppressing cell viability specifically of lung cancer cells but not of the normal lung cells. Upon HTPB treatment, cell cycle arrest was induced and subsequently led to mitochondria-mediated apoptosis. HTPB disrupted F-actin dynamics via downregulating RhoA activity. Moreover, HTPB inhibited activity of MMP2 and MMP9, reduced integrin-β1/focal adhesion complex formation and decreased pericellular poly-fibronectin assemblies. Finally, intraperitoneal injection or oral administration of HTPB efficiently inhibited A549 xenograft tumor growth in vivo without side effects. HTPB delayed lung metastasis of 4T1 mouse breast cancer cells. Acetylation of histone and non-histone proteins, induction of apoptotic-related proteins and de-phosphorylation of focal adhesion kinase were confirmed in treated mice.These results suggested that intrinsic apoptotic pathway may involve in anti-tumor growth effects of HTPB in lung cancer cells. HTPB significantly suppresses tumor metastasis partly through inhibition of integrin-β1/FAK/MMP/RhoA/F-actin pathways. We have provided convincing preclinical evidence that HTPB is a potent HDAC targeted inhibitor and is thus a promising candidate for lung cancer chemotherapy.
PROJECT TITLE: GO FAR — GO WINE

THE AIM OF THE PROJECT IS TO — INCREASE THE — CURRENT LEVEL OF INTERNATIONALISATION OF THE COMPANIES BELONGING TO — ATI (TEMPORARY ASSOCIATION OF ENTERPRISES) THROUGH THE — JOINT ACQUISITION OF SPECIALISED SERVICES FOR THE PROMOTION OF — EXPORT AND THE SHARING OF STRUCTURED ACTIVITIES THAT ALSO ALLOW SMALL COMPANIES COMPETITIVENESS IN THE MARKETS TARGET.THE WINE SECTOR HAS UNDERGONE IMPORTANT TRANSFORMATIONS DUE TO THE INTERNATIONALISATION AND THE ENTRY OF NEW ATTORI.CIO' HAS LED TO A PROFOUND CHANGE IN CONSUMPTION TRENDS AT INTERNATIONAL LEVEL.THE VENETO REGION, WHICH BOASTS CENTURIES-OLD TRADITIONS IN THE PRODUCTION OF WINE, MUST FACE THE RENEWED COMPETITION AND TAKE NOTE OF THE REORGANISATION OF THE SECTOR AT WORLD LEVEL.
PENGARUH CORPORATE SOCIAL RESPONSIBILITY DISCLOSURE DAN UKURAN PERUSAHAANTERHADAP NILAI PERUSAHAAN DENGAN KINERJA KEUANGAN SEBAGAI VARIABEL INTERVENING (Studi Empiris Pada Perusahaan Manufaktur Sektor Barang Konsumsiyang tercatat di BEITahun 2013-2017)

The purpose of this research was to reveal the influence of CSR Disclosure and company size on corporate performance as an intervening variable.The research population is a company that produces goods and services that are suitable for the period 2013-2017 which discusses 37 companies. By using pupose sampling technique, 26 companies were obtained. The analysis is done by multiple regression and diference, the coefficience, the coefficience of determinattion of Adjusted R, t test and f. The CSR ratio has a positive and significant effect on financial performance by using t count of 3.425 and the significance level of t count 0.001 α with one tail = 0.05 and a positive sign, thus it can be said that the SIZE ratio has a positive and significant effect on financial performance. the ratio of CSR and SIZE affects financial performance. F values of 13.412 and sig = 0.000 are smaller than 0.005 of these variables are CSR and SIZE simultaneously on financial performance. Variable ratios of CSR and SIZE affect financial performance. F values of 13.412 and sig = 0.000 smaller than 0.005 are CSR variables and SIZE simultaneously between financial performance. for more corporate responsibility to be able to increase the value of the company. Keywords: CSR, company size, company value, ROA
Evaluation of ionic liquids as solvent for aromatic extraction: Experimental, correlation and COSMO-RS predictions

For the study of the separation of benzene or toluene from octane, nonane and cyclooctane, the ionic liquids 1-butyl-3-methylimidazolium methylsulfate, BMimMSO 4 , and 1-butyl-3-methylimidazolium bis(trifluoromethylsulfonyl)imide, BMimNTf 2 , were used as solvents. The (liquid + liquid) equilibria of the ternary systems {octane, or nonane, or (cyclooctane + benzene + BMimMSO 4 )}, and {(nonane + toluene + BMimMSO 4 ) or BMimNTf 2 } at T  = 298.15 K were determined, and an analysis of the influence of the structure of each compound was carried out. Besides, the experimental data have been compared with literature data with sulfolane as solvent. The experimental results obtained have been correlated using NRTL and UNIQUAC models. Finally, COSMO-RS has been used to predict the (liquid + liquid) equilibrium of the systems studied. The differences between the predicted and experimental values were used to evaluate the ability of the COSMO-RS model to describe the impact of the structure of the alkane, aromatic and ionic liquid on the (liquid + liquid) equilibria.