SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Influence of baseline ejection fraction on the prognostic value of paravalvular leak after transcatheter aortic valve implantation

Moderate or severe paravalvular leak (PVL ≥ moderate) after transcatheter aortic valve implantation (TAVI) is associated with poor outcomes. The aim of this study was to assess whether the baseline ejection fraction (EF) affects the impact of PVL on mortality after TAVI.We analyzed 514 consecutive patients with native severe aortic stenosis who underwent TAVI. Patients were divided into two groups: EF < 40% group (n = 84) and EF ≥ 40% group (n = 430) according to baseline EF.The mean age was 79.5 years and 49% were male. Patients in the EF < 40% group were younger and with higher logistic EuroSCORE compared to patients in the EF ≥ 40% group. Diabetes, coronary artery disease, atrial fibrillation and renal insufficiency were more prevalent in the EF < 40% group. Patients in the EF <40% group had more mitral regurgitation. In-hospital mortality was significantly higher in the EF < 40% group (8.3% vs. 0.9%, p < 0.0001). PVL ≥ moderate was significantly associated with increased 2-year estimated mortality only in the EF <40% group (65% vs. 20%, log-rank p < 0.0001) whereas no difference was seen in the EF ≥40% group (24% vs. 19%, log-rank p = 0.509). Interaction between PVL ≥ moderate and EF < 40% was statistically significant.The impact of PVL ≥ moderate on mortality after TAVI was significant in the EF <40% group but not in the EF ≥ 40% group in our study. Even though operators should aim to minimize PVL in all TAVI patients, special attention is required for patients with reduced baseline EF.
Studies on the effect of plant growth regulators on growth, flowering and yield of african marigold (Tagetes Erecta L.) cv. Pusa Narangi Gainda

The present investigation was conducted at Horticulture Research Farm, Department of Horticulture, ChoudharyCharan Singh University, Meerut, during the year 2007–2008.The experiment was laid out in Randomized Block Design, consisting 9 treatments with control.Two growth regulators namely gibberellic acid (GA3) and cycocel (CCC) were taken. There were four levels of GA3, i.e. 200 ppm, 250ppm, 300ppm and 350 ppm and four levels of cycocel, i.e. 1200ppm, 1600ppm, 2000 ppm and 2400 ppm along with one control (water spray), were taken for both the growth regulators. Gibberellic acid application at 350 ppm was found most effective as it gave highest flower yield per plant, maximum fresh weight per flower and highest number of flowers per plant and earlier flower bud initiation and flowering and also increase number of leaves as well as with maximum height of the plant. Cycocel application at 2400 ppm was found most effective as it gave highest number of leaves per plant and maximum number of main branches per plant. Application of cycocel2000 ppm also beneficial as it gave 28.71 percent more flower yield (i.e. 229.68g/plant) as compared to control (i.e. 178.44g/plant) with increasing number of flowers per plant without affecting initiation of flower bud and commencement of flowering.Thus the present investigation clearly indicate that the application of gibberellic acid at 350 ppm was best treatment in all respect as it enhanced vegetative growth and flower yield along with earlier. Further, cycocel at 2000 ppm was also beneficial as it increased flower yield and reduced vegetative growth without affecting initiation of flower bud and commencement of flowering.
Investigating the activity of transposon derived regulatory sequences in the placenta

Aberrant epigenetic regulation of placental function is implicated in several complications of pregnancy, such as preeclampsia, recurrent pregnancy loss and fetal growth restriction. Notably, the placenta has a unique epigenetic landscape, permissive for the activity of transposable element (TE) derived DNA sequences. TEs are often co-opted by the host genome as cis-regulatory elements, driving tissue- and species-specific gene expression programs. Indeed, TEs contribute many placental-specific enhancers in mouse trophoblast. However, the presence and role of a similar TE-derived regulatory network has not been explored in human trophoblast. As TEs are highly species-specific, such a network in humans would be expected to regulate species-specific placental characteristics, such as the deep interstitial invasion unique to great apes. TE-derived regulatory elements may therefore be important for placental homeostasis and be involved in diseases characterised by aberrant placental invasion. I propose to map TE-derived cis-regulatory sequences in human trophoblast ex vivo using their histone modification signatures. I will assess the regulatory potential of candidate TEs through transcriptomic analyses and motif analysis to reveal transcription factor binding sites, highlighting promising candidates of importance in the human placenta. I will then directly test the function of top TE candidates using CRISPR-Cas9 genome editing of the TEs in trophoblast in vitro, and measuring changes in expression of target genes. Finally, I will elucidate epigenetic and coding differences between complicated and normal control placentas at the functional regulatory TE loci I find, to identify correlations with disease. This project will provide a comprehensive analysis of an as-yet unexplored aspect of human placental epigenetic regulation, and potentially identify novel causes of common unexplained complications of human pregnancy.
Insulating varnish and insulating laminate

Insulating varnish comprises a base coat and an additive of a lubricant. Independent claims are also included for: (1) an insulation laminate (12) comprising a base laminate layer (14), which is at least on one of its flat sides coated with a layer of an insulation varnish; and (2) introducing at least one winding in one winding groove of a stator or rotor, comprising (i) laying out at least one winding groove with an insulating laminate, (ii) pulling a winding conductor in at least one winding groove under room temperature conditions, and (iii) grouting of the winding conductor in at least one winding groove under an elevated temperature.
Sediment Resuspension and Transport by Internal Solitary Waves

Large-amplitude internal waves induce currents and turbulence in the bottom boundary layer (BBL) and are thus a key driver of sediment movement on the continental margins. Observations of internal wave–induced sediment resuspension and transport cover significant portions of the world's oceans. Research on BBL instabilities, induced by internal waves, has identified several mechanisms by which the BBL is energized and sediment may be resuspended. Due to the complexity of the induced currents, process-oriented research using theory, direct numerical simulations, and laboratory experiments has played a vital role. However, experiments and simulations have inherent limitations as analogs for oceanic conditions due to disparities in Reynolds number and grid resolution, respectively. Parameterizations are needed for modeling resuspension from observed data and in larger-scale models, with the efficacy of parameterizations based on the quadratic stress largely determining the accuracy of present field-scale efforts.
Method of and apparatus for strip blow-off

The invention relates to a method of strip blow-off at an exit of rolling mills for producing a spotless and clean rolled strip, according to which the strip (5) is blown off with at least one nozzle (16) arranged above the upper side (14) of the strip, and a rolling oil/emulsion stuck on the strip (5) is aspirated from their edges (18′, 18″) by a suction device (20), and wherein on the upper side (14) and a lower side (15) of the strip (5), a chamber (21, 22) in which overpressure prevails, is formed and to a corresponding device.
SlowFood-CE: Culture, Heritage, Identity and Food

“I need to know the history of what I eat, not only the price. I need to know where it comes form, the hands that farmed and produced it … the day food has lost its true value and its history, there will be no hope for the future.” Carlo Petrini, Slow Food President. The intangible cultural heritage of food is an enormous yet underestimated resource, gastronomy treasures the entire history of a territory and embodies how different cultures have merged over the centuries. It is largely used to promote tourism but hardly ever treated as a resource that can leverage environmental sustainability and social integration. Our objective is to improve the capacities of local actors to valorise the intangible heritage of food in a vision that integrates economic, environmental and social sustainability, increasing as a result their knowledge of the richness of the gastronomic heritage and the skills needed to valorise it creatively. Cities are a perfect laboratory where such a change can be successfully achieved: small enough to strongly influence the entrepreneurial and social scene but also large enough to serve as gateways to international markets. The project is founded on the “new-gastronomy” concept that Slow Food as a movement promotes, A multidisciplinary approach to food that recognizes the strong connections between plate, planet, and people. The project intends to build a transferable model capable to valorise traditional foods with their producers, the breeds and seeds, the traditional processing techniques, the folklore, the cultural landscape, the natural resources nurturing and connecting urban dwellers and rural communities, enhancing the common assets of food heritage in CE and leading to a new alliance among 5 CE heritage cities for the benefit of local administrators, civil society, small business in the food, hospitality and creative sector and citizens at large.
Identifying Preferences for Equal College Access, Income, and Income Equality

Revealed preferences for equal college access may be due to beliefs that equal access increases societal income or income equality. To isolate preferences for those goods, we implement an online discrete choice experiment using social statistics generated from true variation among commuting zones. We find that, ceteris paribus, the average income that individuals are willing to sacrifice is (1) $4,984 to increase higher education enrollment by 1 standard deviation (14 percent); (2) $1,168 to decrease rich/poor gaps in higher education enrollment by 1 standard deviation (8 percent); and (3) $2,900 to decrease the 90/10 income inequality ratio by 1 standard deviation (1.66). In addition, we find that political affiliation is an important moderator of preferences for equality. While both Democrats and Republicans are willing to trade over $4,000 to increase higher education enrollment by 1 standard deviation, Democrats are willing to sacrifice nearly three times more income to decrease either rich/poor gaps in higher education enrollment or the 90/10 income inequality ratio by 1 standard deviation.
Impacto de líderes regionales en construcción de organismos de cooperación regional-Hugo Chávez en Unasur

The present research seeks to determine if charismatic leaders influence during the construction of international organizations, and if this influence becomes the reflection of the most important aspects of a leader personality over the institution. The international relations theory that guides this study is constructivism, since, in it, the leaders play a very important role in the construction of intersubjective structures and concepts in specific topics, such as Latin American cooperation. The empirical case analyzed to determine this influence is Hugo Chavez and the creation of the Union of South Amrican Nations. The methodology of analysis used to fulfill these objectives is composed of three steps. During the first step, characteristics of Chavez are examined to determine if they are consistent with those of a charismatic leader, through the application of a three-dimensional definition: social, relational, and psychological. The second step refers to the description and analysis of the structure of UNASUR, in the light of its constitutive treaty. And during the third step, the most important components of both leader and institution are contrasted to determine if there are similar features sufficient to establish a meaningful correlation. The results reached is that Hugo Chavez is a charismatic leader. However, his influence on the construction of UNASUR was not sufficient to determine that it reflects characteristics of its personality.
Early stage investing launchpad - unleashing the potential of early stage investing in europe

ESIL will establish an EU Framework for capacity building for early-stage investors in Europe, facilitating the take up of Angel Investing, overcoming obstacles related to market outreach and engaging key actors e.g. entrepreneurs, unconventional early stage investors and crowdfunding.
To maximise impact ESIL will deliver dedicated actions, tools and mobilise expertise for every investor at any given stage of his/her experience, from awareness to actual investment to ""bring on board” local and international investment capacities, increasing the conversion rate in the journey from the awareness raising to the actual investments
ESIL will use state of the art on line material and best in class technology platform, but at the same time will engage top Business Angels in intimate events with local champions boosting the process in an informal, peer2peer fashion especially in countries with a younger Angel market
The potential is huge, even if we want to count on the most optimistic estimates of 250k business angels today active in Europe this is still far from e.g. the 3mln HWNI Europe can count on
ESIL will take special care of less developed market, transferring and adapting all the knowledge of its partners but will also work on improving the more developed market that have big challenges such as illiquidity and co-investments
ESIL will target all the members of local BA groups, as well as individual investors, successful entrepreneurs, institutional players in EU28 and H2020 Associate Countries
Connecting ecosystem actors (including policy makers) and investors and demonstrating how this pays off will contribute to short-term impact and sustainability. The interaction among different communities and typology of stakeholders (for profit and not for profit, conventional and unconventional, etc.) made possible by the nature of the consortium partners, will promotes cross-fertilization, mutual understanding and open up opportunities for further cooperation and take up.
The role of 5ht3a inhibitory interneurons in sensory processing

How do cortical circuits process sensory stimuli that leads to perception? Sensory input is encoded by complex interactions between principal excitatory neurons and a diverse population of inhibitory cells. Distinct inhibitory neurons control different subcellular domains of target principal neurons, suggesting specific roles of different cells during sensory processing. However, the individual contribution of these inhibitory subtypes to sensory processing remains poorly understood. This is mainly due to the technical challenges of recording the activity of identified cell types in-vivo, in response to quantified sensory stimuli. Therefore, I propose a novel approach based on four pillars: 1) An optically accessible circuit in the superficial layers of the cortex, comprised of inhibitory cells expressing the serotonin receptor 5HT3a, and the distal dendrites of pyramidal neurons. 2) A novel combination of electrophysiology and 3D two-photon imaging to simultaneously record the activity of morphologically identified 5HT3a cells and their dendritic targets. 3) A head-fixed perceptual decision task, whereby mice use their whiskers to determine the location of an object, allowing an accurate description of the sensory stimulus. 4) The integration of experimental data and computer models to gain mechanistic insights into circuit functions. The 5HT3a cells and the distal dendrites of pyramidal neurons receive ‘top-down’ contextual information from other cortical areas that is essential for constructing meaningful perceptions of sensory stimuli. Thus I hypothesize that 5HT3a cells influence sensory perceptions by controlling the excitability of the pyramidal cell distal dendrites that integrate top-down and sensory input. Thus, I will not only reveal novel functions of inhibitory neurons, I will also shed light on how top-down and sensory input is integrated, and I will provide novel methods to test the functions of other cell types in normal mice and disease models.
Manganese Alkane Complexes: An IR and NMR Spectroscopic Investigation

Manganese propane and manganese butane complexes derived from CpMn(CO)(3) were generated photochemically at 130-136 K with the alkane as solvent and characterized by FTIR spectroscopy and by (1)H NMR spectroscopy with in situ laser photolysis. Time-resolved IR spectroscopic measurements were performed at room temperature with the same laser wavelength. The ν(CO) bands in the IR spectra of the photoproducts in propane are shifted to low frequency with respect to CpMn(CO)(3), consistent with formation of CpMn(CO)(2)(propane). The (1)H NMR spectra conform to the criteria for alkane complexes: a high-field resonance for the η(2)-CH protons that shifts substantially on partial deuteration of the alkane and exhibits a coupling constant J(C-H) on (13)C-labeling of ca. 120 Hz. The NMR spectrum of each system exhibits two diagnostic product resonances in the high-field region for the η(2)-CH protons, corresponding to CpMn(CO)(2)(η(2)-C1-H-alkane) and CpMn(CO)(2)(η(2)-C2-H-alkane) isomers. Partial deuteration of the alkane at C1 results in characteristic strong isotopic perturbation of equilibrium of the η(2)-CH resonance of CpMn(CO)(2)(η(2)-C1-H-alkane). With propane-(13)C(1), the η(2)-CH resonance of CpMn(CO)(2)(η(2)-C1-H-alkane) isomer exhibits (13)C satellites with J(C-H) = 119 Hz. The corresponding resonance of CpMn(CO)(2)(η(2)-C2-H-alkane) is identified by use of propane-2,2-d(2). The lifetimes of the (η(2)-C1-H-alkane) isomers of the manganese complexes were determined by NMR spectroscopy as 22 ± 2 min at 134 K (propane) and 5.5 min at 136 K (butane). The corresponding spectra and lifetimes of the CpRe(CO)(2)(alkane) complexes were measured for reference (CpRe(CO)(2)(propane) lifetime ca. 60 min at 161 K; CpRe(CO)(2)(butane) 13 min at 171 K). The lifetimes determined by IR spectroscopy were similar to those determined by NMR spectroscopy, thereby supporting the assignments. These measurements extend the range of alkane complexes characterized by NMR spectroscopy from rhenium and rhodium derivatives to include less stable manganese derivatives.
Processing of Global and Selective Stop Signals

This paper applied Donders’ subtraction method to examine the processing of global and selective stop signals in the stop-signal paradigm. Participants performed on three different versions of the stop task: a global task and two selective tasks. A global task required participants to inhibit their response to a go signal whenever a stop signal was presented (Stop-a task). A selective stop task required participants to inhibit to one stop signal but not to the other (Stop-c task). Another selective stop task required them to inhibit when the response indicated by go and stop signals was the same but not when they were different (Stop-b task). Stop-signal reaction time (SSRT) was shortest for Stop-a and longest for Stop-b, with intermediate values for the Stop-c task. Additional control experiments that manipulated stop probability confirmed the robustness of global and selective stopping latencies even when the stop-signal probability varied. The current findings contribute to the conclusion that Donders’ subtraction method provides a useful tool for estimating the durations of subprocesses that together comprise SSRT.
Comparative study on feature descriptors for brain image analysis

A key obstacle to developing automated histopathology assessment tools is the difficulty of defining quantifiable image features that could serve as fundamental data elements capable of distinguishing key disease types and subtypes. A variety of feature extraction and selection methods for histology images have been proposed. However, comparisons of different feature descriptor approaches remains challenging because of varying datasets and emphases chosen by different authors. As an example of how a shared reference atlas could accelerate efforts in this area. In this study, we constructed normal and disease sample datasets by standardizing histology images employed from Allen Brain Atlas. After preparing the datasets, we extracted features mentioned in the preceding studies from the datasets to characterize normal and disease tissues. To confirm statistical significance between the normal and disease images, Kolmogorov-Smirnov test was employed. The experimental results indicated that topological features are effective to distinguish the normal images from the disease ones. This paper also shows the details of construction of the datasets, segmentation of nuclei, feature descriptors and the experimental results. We discuss the effectiveness and generalizability of derived features.
Establishment and exploitation of a european-latin american research consortium towards eradication of preventable gallbladder cancer

Gallbladder cancer (GBC) is a neglected disease with huge potential for prevention. This project aims at significantly improving the accuracy of risk estimation and early detection of GBC by identifying and adequately considering geographical, environmental, lifestyle, ethnic, gender and molecular differences. We plan to generate the information needed to establish and refine current prevention programmes, including the primary, secondary and tertiary prevention of GBC. We will (1) build a unique European–Latin American GBC biorepository integrated into a tailored IT platform, (2) identify, validate and functionally characterize novel GBC biomarkers, (3) develop a multifactorial risk score that integrates established and newly identified epidemiological and molecular risk factors, (4) improve the understanding of the causal mechanisms that link lifestyle, cultural and behavioural factors to GBC development, (5) unravel novel opportunities for the targeted therapy of incidental GBC, (6) exploit existing and newly generated epidemiological and multi-omics data to improve the accuracy of GBC risk prediction and (7) contribute to the training of the next generation of Latin American researchers in precision medicine for GBC. The generated information will permit identification of individuals at high GBC risk, guiding surveillance and individual decisions on the possible benefit of preventive gallbladder removal in regions of low and high GBC incidence. Novel data on genomic alterations in incidental GBC will pave the way towards implementation of future clinical trials. The planned European–Latin American GBC biorepository and IT platform will constitute a prime resource for translational research on individualized prevention, personalized early detection and targeted therapy of GBC. The participation in our project of representatives of health authorities, patients and the industry guarantees the efficient incorporation of project results into national health policies.