SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Formas de apoio/suporte ao cuidador de pessoas em atenção domiciliar: protocolo de revisão de escopo

Objetivo: mapear as formas de organização de apoio/suporte ao cuidador domiciliar de pessoas dependentes funcionalmente no Brasil e em outros países. Metodologia: Protocolo de Revisão de Escopo, realizado segundo recomendações metodológicas do Joanna Briggs Institute (JBI) e checklist PRISMA Extension for Scoping Reviews (PRISMA- ScR), a fim de responder à pergunta de pesquisa “quais são as formas de organização de apoio/suporte ao cuidador domiciliar de pessoas dependentes funcionalmente no Brasil e em outros países?” elaborada conforme o acrônimo PCC (População; Conceito; Contexto), onde P refere-se aos cuidadores domiciliar, C formas de organização de apoio/suporte e C domicílio, atenção domiciliar. As fontes de informação serão: bases de dados internacionais e nacionais, repositórios, banco de teses e dissertações, fontes institucionais, referências encontradas em artigos selecionados. Serão desenvolvidas três etapas de busca com os termos “home care services”, “caregiver” e “social support”: 1) em bases de dados; 2) em repositórios de teses e dissertações; 3) em documentos institucionais. Para somar à etapa 1, serão identificadas referências das referências dos artigos selecionados para composição do material de análise.
Crucible for melting rare earth element alloy and rare earth element alloy

The present invention provides a crucible containing, as primary components, one or more selected from rare earth element oxides including Y2O3 and Al2O3, which is prepared through the firing at 500 to 1800 DEG C. Such that the rare earth element oxide is distributed in a finer part of a material for the firing having a particle diameter of 0.5 mm or less in a percentage higher than that of a coarser part of the material having a particle diameter of greater than 0.5 mm, and that it contains substantially no reaction products of the above rare earth element oxide with the at least one of Al2O3 and Al2TiO5; and a rare earth element alloy produced by the use of the crucible.
Engineering de novo production of chlorinated polyketides in pseudomonas putida

Sustainable economic development requires new biocatalysts to carry out novel, selective synthesis reactions in an environmentally-friendly fashion. Halogenated organic compounds, key products due to their multiple biological activities and industrial applications, continue to be produced via traditional chemistry and their efficient and cost-effective biosynthesis has not been yet achieved. In the present project, rooted in Metabolic Engineering and Synthetic Biology approaches, I will undertake a complete genetic and metabolic engineering of the model bacterium Pseudomonas putida KT2440 to create a platform for the bio-based production of chlorinated polyketides à la carte, which will contribute to the design of new drug analogues. I will establish and implement a clear roadmap from the extant bacterium to a re-factored version of the microorganism capable of efficiently producing chlorinated precursors, which will be channeled to the synthesis of new-to-nature chlorinated polyketides by reprogrammed modular polyketide synthases enzymes. Furthermore, the broad portfolio of halogenated molecules that can be synthetized with the cell factories from this project will contribute to the European knowledge-based bio-economy, enhance the EU's competitiveness in White Biotechnology and benefit the society as a whole. From a personal perspective, the implementation of this challenging and innovative project in The Novo Nordisk Foundation Center for Biosustainability (DTU Biosustain, the ideal scientific environment to pursue the tasks of DONNA), under the supervision of Dr. Pablo I. Nikel (an expert in the field of Metabolic Engineering of Pseudomonas), will be an unbeatable opportunity for both my professional and personal development. My solid scientific background, on the other hand, ensures a smooth progression as an independent researcher in the field of Metabolic Engineering that will result in a win-win situation for myself and the receiving laboratory.
Towards Efficient Execution of Erasure Codes on Multicore Architectures

Erasure codes can improve the availability of distributed storage in comparison with replication systems. In this paper, we focus on investigating how to map systematically the Reed-Solomon and Cauchy Reed-Solomon erasure codes onto the Cell/B.E. and GPU multicore architecture. A method for the systematic mapping of computation kernels of encoding/decoding algorithms onto the Cell/B.E. architecture is proposed. This method takes into account properties of the architecture on all three levels of its parallel processing hierarchy. The performance results are shown to be very promising. The possibility of using GPUs is studied as well, based on the Cauchy version of Reed-Solomon codes.
Educational-environmental project

The integrated “Spelaion Logos” projects aim at enhancing the Karst cave environment of naturalistically-relevant protected areas - that are part of Natura 2000 - in the Eastern Alpine Arc. They are the result of the cooperation among the various partners, and envisage environmental restoration and improvement activities (creation of thematic routes and infrastructural interventions to improve site fruition) as well as educational/cultural initiatives (educational exhibitions, conferences, promotional and publicity literature). As regards Valcellina, the project aims at the creation of a naturalistic-educational trail with a low impact on the environment, both epygean and hypogean, that comprises - in its open-air portion - the Natural Reserve of Forra del Cellina, and - in its underground portion - the Grotta Vecchia Diga (Old Dam Cave) of Barcis. Also envisaged is the establishment of an multifunctional Educational-naturalistic Centre, that will promote knowledge dissemination and a correct fruition of the fossil caves and the exceptional natural resources present in the Reserve. Project activities also include the setting up of an Image Laboratory/Archives for the study and the dissemination of information on the territory and the creation of a multimedia network for the cultural, technical and scientific exchange between project partners; the organisation of cultural initiatives and events; promotional literature; and symbolic naturalistic/educational itinerary will be set up, targeting school and excursionist tourism, leading from the Pordenone Prealps area to the Julian Prealps and the Slovenian National Park of Triglav. The project is coordinated by a Technical Committee consisting of both Italian and Slovenian partners who, by sharing the competences acquired by individuals, aims at attaching to the actions proposed a high technical and scientific value.
Improving eco-efficiency of bio-energy production and supply in riparian areas of the Danube river basin and other floodplains in Central Europe - DANUBENERGY.

Conventional production of biomass for biogas plants is often eco-inefficient due to the dominant use of maize and the increased risk of soil erosion and nutrient losses, as well as the low use of thermal energy during the generation of electricity in the combined heat and power plant. Furthermore, competition with food production on fertile land and the resulting increase of prices for land and agricultural products causes ethical and socio-economic problems.

Thus, the eco-friendly improvement of bioenergy production processes as well as the opening-up of abandoned natural and agricultural areas for energy production is necessary. Within the project DANUBENERGY the partners will join their forces in order to improve the eco-efficiency of bio-energy production and supply in riparian areas of the Danube river basin and other floodplains in central Europe.
Software Process Architecture: Roadmap

Software Process Architecture is an emergent area of research, with little understanding, scarce experience and confusing terminology. Thus, technical concerns along with its evolution are difficult to express. And it has been until recent time that has received increasing attention as an important sub-area of Software Process Engineering. This paper aims to briefly present main topics of software process architecture addressing three main issues: What is a software process architecture?, How it is created? And who is responsible for building it? (i.e. definition, process and role). It also identifies some challenges and research directions by delineating a roadmap to facilitate its understanding and growth.
Exploring probable reasons for record fatalities: the case of 2011 Joplin, Missouri, Tornado

On the evening of 22 May 2011, an EF-5 tornado tore a path six miles long across Joplin, Missouri, USA, killing 162 people as it passed through the heart of the city. This tornado stands as the deadliest single tornado to hit the United States since modern recordkeeping began in 1950, surpassing the tornado of 8 June 1953 that claimed 116 lives in Flint, Michigan. The record number of deaths caused by the single tornado in Joplin was far higher than the average annual number of US tornado deaths over the last three decades. This study explores the reasons for the high number of fatalities caused by the 2011 Joplin tornado. Questionnaire surveys administered among tornado survivors and informal discussions with emergency management personnel and others suggest that five reasons are associated with the high number of tornado fatalities experienced in Joplin: (1) the sheer magnitude of this event; (2) its path through commercial and densely populated residential areas; (3) the relatively large size of damage area; (4) the physical characteristics of affected homes in Joplin; and (5) the fact that some residents ignored tornado warnings. Several recommendations are offered, the implementation of which should reduce future tornado fatalities not only in Joplin, but elsewhere in the United States.
A comparative study on clinical effect of application of warm gutta- percha filling and cold lateral condensation of gutta- percha for root canal filling

Objective To compare the clinical effect of root canal filling with thermal gutta- percha and cold lateral condensation of gutta- percha filling. Methods Sixty patients with root canal filling were randomly divided into trial group and control group,each group with 30 cases. Patients in trial group were applied with the warm gutta- percha filling,and patients in control group were applied with cold gutta- percha lateral pressure filling,after a follow- up period of 3 months,the postoperative effects were compared between patients of these two groups. Results The filling time for root canal filling in patients of trial group was significantly lower than that of patients in control group( P 0. 05); the difference in case number with periodontal pain after operation between these 2 groups was not significant( P 0. 05); the total clinical effective rate in patients of trial group after 3 months was 96. 7%,it was significantly higher than that( 80. 0%) of patients in control group( P 0. 05).Conclusion The application of thermal gutta- percha root canal filling can decrease the times of periodontal pain,shorten the time for treatment,and effectively improve the clinical curative effect,hence it can be used as the preferred method for root canal filling.
Artificial endosymbiosis

Living organisms have acquired new functionalities by uptake and integration of species to create symbiotic life-forms. This process of endosymbiosis has intrigued scientists over the years, albeit mostly from an evolution biology perspective. With the advance of chemical and synthetic biology, our ability to create molecular-life-like systems has increased tremendously, which enables us to build cell and organelle-like structures. However, these advances have not been taken to a level to study comprehensively if endosymbiosis can be applied to non-living systems or to integrate living with non-living matter. The aim of the research described in the ARTISYM proposal is to establish the field of artificial endosymbiosis. Two lines of research will be followed. First, we will incorporate artificial organelles in living cells to design hybrid cells with acquired functionality. This investigation is scientifically of great interest, as it will show us how to introduce novel compartmentalized pathways into living organisms. It also serves an important societal goal, as with these compartments dysfunctional cellular processes can be corrected. We will follow both a transient and a permanent approach. With the transient route biodegradable nanoreactors are introduced to supply living cells temporarily with novel function. Functionality is permanently introduced using genetic engineering to express protein-based nanoreactors in living cells, or via organelle transplantation of healthy mitochondria in diseased living cells. Secondly I aim to create artificial cells with the ability to perform endosymbiosis; the uptake and presence of artificial organelles in synthetic vesicles allows them to dynamically respond to their environment. Responses that are envisaged are shape changes, motility, and growth and division. Furthermore, the incorporation of natural organelles in liposomes provides biocatalytic cascades with the necessary cofactors to function in an artificial cell
Application of Numerical Simulation in Land Subsidence Analysis in Xiqing District of Tianjing

Land subsidence,the main geological disaster in Tianjin,is mainly caused by water resource shortage and over-exploitation. By using Processing Modflow,the paper makes a numerical simulation of groundwater flow to explore the relationship between land subsidence and groundwater. To build the numerical simulation model,the study build a concept model and math model of the hydrogeological conditions,according to which hydrogeological parameters which may reflet the reality are identified. The comparison between data from numerical simulation model and on-site data indicates that the model is accurate,and the groundwater flow curve is in accordance with land subsidence curve. Tests in this paper indicate that when the parameters used in numerical simulation model establishment can reflect real hydrogeological conditions,the numerical simulation method could be used to present the process of land subsidence though the simulate data has few errors with field measurements.
An Overview of Recent Phased Array Measurements at NASA Glenn

A review of measurements made at the NASA Glenn Research Center using an OptiNAV Array 48 phased array system is provided. Data were acquired on a series of round convergent and convergent-divergent nozzles using the Small Hot Jet Acoustic Rig. Tests were conducted over a range of jet operating conditions, including subsonic and supersonic and cold and hot jets. Phased array measurements were also acquired on a Williams International FJ44 engine. These measurements show how the noise generated by the engine is split between the inlet-radiated and exhaust-radiated components. The data also show inlet noise being reflected off of the inflow control device used during the test.
Training in mountain occupations

The FORMEMO project intends to work on mountain professions and culture in order to enhance the professional heritage of the Alpine territories in the ALCOTRA area, and in particular Piedmont, the Aosta Valley and Haute-Savoie. The aim is to revalorise the mountain territory from the point of view of the present professions so that they add value to the available territorial heritage. FORMEMO aims to fill a gap in the field of professional training through a joint and synergistic design of training courses aimed at enhancing the skills of people who already live and work in the Alps.
Peanut allergen in house dust of eating area and bed - a risk factor for peanut sensitization?

It has been hypothesized that high environmental exposure to peanut allergens may be a potent risk factor for cutaneous sensitization. Therefore, we wanted to investigate whether peanut proteins are detectable in house dust of different household areas. Peanut levels of dust samples were measured with ELISA. Overall, peanut was detectable in 19 of 21 households in the eating area and/or in bed. The frequency of peanut consumption correlated with peanut levels. Forty-eight hours after intentional peanut consumption, peanut levels were highly increased. Nevertheless, further research is required to prove whether peanut allergen in house dust can cause sensitization via skin.
Who were the urban gentry? Social elites in an English provincial town, c. 1680–1760

ABSTRACT This paper explores the identity and social worlds of the ‘urban gentry’ of Chester as they developed from the late seventeenth to the mid eighteenth century. In place of the political and cultural definitions which characterise analyses of this group, it takes the self-defined ‘occupational’ titles of probate records as a starting point for an investigation into the background and activities of those styling themselves ‘gentleman’. Central to their identity were networks of friendship and trust. These reveal the urban gentry to have been closely tied with both the urban middling sorts and the rural gentry: a position which at once reflected and underpinned their particular situation within eighteenth-century society.
Mass Spectrometric/Bioinformatic Identification of a Protein Subset That Characterizes the Cellular Activity of Anticancer Peptides

The preclinical study of the mechanism of action of anticancer small molecules is challenging due to the complexity of cancer biology and the fragmentary nature of available data. With the aim of identifying a protein subset characterizing the cellular activity of anticancer peptides, we used differential mass spectrometry to identify proteomic changes induced by two peptides, LR and [d-Gln(4)]LR, that inhibit cell growth and compared them with the changes induced by a known drug, pemetrexed, targeting the same enzyme, thymidylate synthase. The quantification of the proteome of an ovarian cancer cell model treated with LR yielded a differentially expressed protein data set with respect to untreated cells. This core set was expanded by bioinformatic data interpretation, the biologically relevant proteins were selected, and their differential expression was validated on three cis-platinum sensitive and resistant ovarian cancer cell lines. Via clustering of the protein network features, a broader view of the peptides' cellular activity was obtained. Differences from the mechanism of action of pemetrexed were inferred from different modulation of the selected proteins. The protein subset identification represents a method of general applicability to characterize the cellular activity of preclinical compounds and a tool for monitoring the cellular activity of novel drug candidates.
Microfluidic pillar array sandwich immunofluorescence assay for ocular diagnostics

Uveitis and primary intraocular lymphoma (PIOL) are diseases associated with the invasion of lymphocytes into various regions of the eye, accompanied by expression of inflammatory cytokines. While these diseases are very different in terms of survivability and treatment options they have similar symptoms that make accurate diagnosis challenging. Furthermore, the diagnostic yield with state-of-the-art techniques for cell and cytokine analysis of vitreous and aqueous humor samples is under 20% due to inadequate sensitivity. This paper describes a simple sandwich immunofluorescence assay (sIFA) microfluidic device that is capable of identifying important analytes in ocular biopsies as a potential alternative to current diagnostic approaches. Detection is accomplished by capture of the target molecules on antibody-coated, vertical, oval shaped pillars in a microfluidic device followed by a biotinylated detection antibody and finally fluorescent avidin for target molecule quantification. Cytokine concentration measurements were carried out on aqueous humor samples from rats with endotoxin-induced uveitis as well as human cataract patients. Results correlated well with conventional protein quantification techniques and additionally, measurements from the human samples surpassed detection limits of current state-of-the-art immunoassay techniques. The single-digit femtomolar range of detection of this sIFA system provides lower limits of detection when compared to traditional techniques and allows for the mapping of the cytokine content of vitreous biopsies with detection limits that have yet to be realized using cost effective microfluidics. Furthermore, the relative simplicity of the device design, fabrication and ability to automate makes it easily translatable from the laboratory to a clinical setting.
The challenges of understanding glycolipid functions: An open outlook based on molecular simulations

Glycolipids are the most complex lipid type in cell membranes, characterized by a great diversity of different structures and functions. The underlying atomistic/molecular interactions and mechanisms associated with these functions are not well understood. Here we discuss how atomistic and molecular simulations can be used to shed light on the role of glycolipids in membrane structure and dynamics, receptor function, and other phenomena related to emergence of diseases such as Parkinson's. The cases we discuss highlight the challenge to understand how glycolipids function in cell membranes, and the significant added value that one would gain by bridging molecular simulations with experiments. This article is part of a Special Issue entitled Tools to study lipid functions.
Ovage: an innovative, user-friendly digital methodology that quantifies ovarian reserve by integratingclinical, biochemical and 3d-sonographic data to help decision-making in all phases of woman life

OvAge s.r.l. is the owner of a pioneering patented medical device-software able in quantifying women ovarian reserve (both in term of fertility potential and distance to menopause) by integrating clinical, biochemical and 3D-ultrasonographic data.
For the first time in this field of medicine, this instrument, also called OvAge®, gives as a result explicitly the ovarian age of a woman, a ready-to-use information that is going to revolutionize the relationship of women with themselves and with the Specialists in the field of Gynaecology.
OvAge s.r.l. objective is to diffuse its innovative research product all over the world, with the purpose of helping both women (healthy or affected by infertility, benign or malignant pathologies) and physicians (general and specialists) in the management of many frequent conditions affecting the reproductive life of a woman.
In this way, OvAge® aims to contribute the sustainability of health care systems, by reducing both costs related to late diagnosis of infertility and those related to useless surgeries in women affected by benign pathologies for which menopause is the best and cheaper therapy. Moreover, OvAge® will solve women needs for life planning by predicting reproductive potential and for safely solving common pathologies by predicting distance to menopause.
To reach these goals, a feasibility study is needed. It will produce a market study for each European member state,proposals on best practice to enhance customer loyalty, a risk assessment of the plan and a potential licensing in order to launch OvAge® software medical device in the EU market initially through a web site. Later, OvAge s.r.l. aim to commercialize its product in the rest of the world (phase 2) as a medical hardware device.
The most relevant market segment for OvAge® is the population of women residents in all EU countries, although our challenges and markets are global, since infertility and female pathologies are the same in all parts of the world.