SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Identification of major clonal complexes and toxin producing strains among Staphylococcus aureus associated with atopic dermatitis

Staphylococcus aureus promotes the onset and severity of atopic dermatitis (AD), which is exacerbated by superantigen toxins SEB and SEC. The genetic identity of these isolates, and their relationship to common hospital- or community-associated methicillin resistant S. aureus (HA-MRSA and CA-MRSA) has not been defined. We conducted spa typing, partial multi-locus sequence typing (MLST), and toxin profiling (seb, sec, lukS-PV) of S. aureus from 119 pediatric and 40 adult AD patients. MLST clonal complexes CC45, CC5, CC15, CC1, CC8 and CC30 accounted for 79% of isolates, representing the same major groups reported for nosocomial S. aureus in hospital intensive care units. The highest disease severity was associated with CC1, which was significantly greater relative to CC15 (p = 0.017) or CC30 (p = 0.040), but with no significant difference relative to CC45, CC5 or CC8. Although there were two few lukS-PV, seb or sec isolates to infer a role in disease severity, CC45 was identified as a source of SEC producing strains, and lukS-PVL was associated with a small number of CC5 pediatric isolates. CC1 harbored the only CA-MRSA that was identified, and was a source of isolates that expressed both seb and sec, and closely resembled the USA400 strain of CA-MRSA.
Antitumour saccharide conjugates.

The invention concerns a process for preparing glycoconjugates of phosphoramides of general formula (1) and (1a) in which the sugar is linked to the phosphoramide mustard function or the ifosfamide mustard function preferably in the 1 position and R1 and R2 are identical or different and may denote hydrogen, lower C1-C4 alkyl or C1-C6 alkyl halide and the sugar may be present as mono-, di- or polysaccharides in all existing isomeric and enantiomeric forms by conjugating protected bromine sugar in a manner known per se with the corresponding phosphorus compounds and releasing it from the protective groups. Also described are D-glycopyranosyl-N,N'-di(2-chloroethyl)-phosphoric acid diamides and the use of the compounds as antitumoral agents.
High-quality single crystalline NiO with twin phases grown on sapphire substrate by metalorganic vapor phase epitaxy

High-quality single crystalline twin phase NiO grown on sapphire substrates by metalorganic vapor phase epitaxy is reported. X-ray rocking curve analysis of NiO films grown at different temperatures indicates a minimum full width at half maximum of the cubic (111) diffraction peak of 0.107° for NiO film grown at as low as 550 °C. Detailed microstructural analysis by Φ scan X-ray diffraction and transmission electron microscopy reveal that the NiO film consists of large single crystalline domains with two different crystallographic orientations which are rotated relative to each other along the [111] axis by 60°. These single crystal domains are divided by the twin phase boundaries.
REAL-TIME ESTIMATION OF RESERVOIR POROSITY FROM MUD GAS DATA

Systems and methods include a method for generating a real-time reservoir porosity log. Historical gas-porosity data is received from previously-drilled and logged wells. The historical gas-porosity data identifies relationships between gas measurements obtained during drilling and reservoir porosity determined after drilling. A gas-porosity model is trained using machine learning and the historical gas-porosity data. Real-time gas measurements are obtained during drilling of a new well. A real-time reservoir porosity log is generated for the new well using the gas-porosity model and real-time gas measurements.
Modelling Rainfall Runoff Relations Using HEC-HMS and IHACRES for a Single Rain Event in an Arid Region of Jordan

The HEC-HMS and IHACRES rainfall runoff models were applied to simulate a single streamflow event in Wadi Dhuliel arid catchment that occurred on 30–31/01/2008. Streamflow estimation was performed on the basis of an hourly scale. The aim of this study was to develop a new framework of rainfall-runoff model applications in arid catchments by integrating a re-adjusted satellite-derived rainfall dataset (GSMaP_MVK+) to determine the location of the rainfall storm. The HEC-HMS model was applied using the HEC-GeoHMS extension in ArcView 3.3 while the IHACRES is Java-based version model. The HEC-HMS model input data include soil type, land use/land cover, and slope. By contrast, the lumped model IHACRES was also applied, based on hourly rainfall and temperature data. Both models were calibrated and validated using the observed streamflow data set collected at Al-Za’atari discharge station. The performance of IHACRES showed some weaknesses, while the flow comparison between the calibrated streamflow results fits well with the observed streamflow data in HEC-HMS. The Nash-Sutcliffe efficiency (Ef) for the two models was 0.51 and 0.88 respectively.
Monossialitização como principal processo de intemperismo químico no planalto alcalino de Poços de Caldas (MG)

As características das águas fluviais são fortemente influenciadas pelos processos de intemperismo químico das rochas em uma bacia hidrográfica. Assim, este trabalho investigou a influência do processo de intemperismo químico na composição das águas superficiais no planalto alcalino de Poços de Caldas, estudando-se a bacia do Córrego Ariranha. Os parâmetros físicos e químicos foram avaliados mensalmente, totalizando doze amostragens ao longo de 2016. Os resultados indicaram que as águas do Córrego Ariranha são constituídas majoritariamente pelos íons dissolvidos HCO3 - e Na+. A descarga dissolvida total foi de 247,6 t/a em 2016, com a maior parte sendo transportada no período úmido (75,6%). O fluxo anual específico de 25,3 t/km2 /a é inferior ao quantificado em outras bacias hidrográficas formadas por rochas alcalinas no Brasil e no mundo, independentemente das condições climáticas de cada região. As águas do Córrego Ariranha sãocontroladas pela mistura das águas pluviais e os processos de monossialitização dos minerais silicatos que compõe as rochasalcalinas do planalto de Poços de Caldas.
PANELES DE TABLERO PARA PUENTES, METODOS DE FABRICACION DE LOS MISMOS Y PUENTES QUE TIENEN DICHOS PANELES

Los paneles o tableros de puentes para paneles de puentes hechos de metal-plástico-enfrentados con un plástico unido a las placas de metal de manera de transmitir las fuerzas de deslizamiento entre las mismas. Las placas enfrentadas pueden ser construidas tanto con un nucleo plástico solido o un nucleo compuesto que esté formado por plástico, placas de metal o formas estructurales y formas, dentro o fuera de una estructura de vigas. Los paneles de placas enfrentadas para puentes sin estructuras de metal periféricas se unen solo mediante la adhesion del plástico a las placas de metal.
The (5‐4) and (6‐4) Adducts of 1‐Methylthymine and Their Dewar Valence Isomers

Previous studies of the photochemical reaction of 1-methylthymine (MeT) in frozen aqueous solution have indicated that four cyclobutane type dimers are formed. We have restudied this system and have found that, in addition to cyclobutane dimers, both a (5-4) adduct and a (6-4) adduct of MeT are formed in significant amounts. Upon standing in aqueous solution, the (5-4) adduct is susceptible to reaction to form an isomeric form of the parent adduct, possibly via ring-opening and closure reactions at C-6 of the saturated pyrimidine ring component of the adduct. Irradiation of each of these three adducts with UVB light produces a pair of Dewar-type adducts. The nine products were individually characterized by mass spectrometry, proton NMR spectroscopy and UV spectroscopy. A less comprehensive study showed that irradiation of thymidine in frozen aqueous solution produces a diastereomeric pair of (5-4) adducts, along with the previously known diastereomeric pair of (6-4) adducts.
Medical students, spirituality and religiosity-results from the multicenter study SBRAME

To evaluate the relationship between spirituality/religiosity (S/R) and the attitudes, beliefs and experiences of medical students in Brazil with respect to S/R in their undergraduate training and clinical practice.SBRAME (Spirituality and Brazilian Medical Education) is a multicenter study involving 12 Brazilian medical schools with 5950 medical students (MS). Participants completed a questionnaire that collected information on socio-demographic data and S/R in their undergraduate training and practice.Of all MS, 3630 participated in the survey (61.0%). The sample was 53.8% women and the mean age was 22.5 years. The majority of MS believed that spirituality has an impact on patients' health (71.2%) and that this impact was positive (68.2%). The majority also wanted to address S/R in their clinical practice (58.0%) and considered it relevant (75.3%), although nearly one-half (48.7%) felt unprepared to do so. Concerning their training, most MS reported that they had never participated in a "spirituality and health" activity (81.0%) and that their medical instructors had never or rarely addressed this issue (78.3%). The majority also believed that they should be prepared to address spiritual issues related to the health of their patients (61.6%) and that this content should be included in the medical curriculum (62.6%).There is a large gap between MS attitudes and expectations and the S/R training that they are receiving during their undergraduate training. The majority of MS surveyed believe that patients should have their beliefs addressed and that these beliefs could have important effects on their health and the doctor-patient relationship. These results should stimulate discussion about the place that S/R training should have in the medical curriculum.
Patterns of land-use and human mobility in a time of climate changes (italy, 6th to 10th cc.)

The period from the sixth- to eleventh- century in Italy is one of the most profound political and social laboratories in European history. Centered on this region and period, the primary goal of the In&Around project is to chart the effects of climate change on human behaviour. By focusing on early and high medieval Italy, the project aims at exploring the interaction between climate variability and human agency with a lens towards management of the environment and in the light of shifting political regimes, while capturing details on past issues of contemporary significance like human mobility and workforce relocation.  Within the area of Italy, two micro-regions with distinct medieval histories are targeted for specific investigation: Lucca and Rieti.  The project will generate new long-duration and high-resolution climate records from recently cored lake sediments combined with data derived from written sources and already extant climate reconstructions. By way of its innovation-through-interdisciplinary approach, the project will offer important opportunities for expanding the applicant’s expertise through integrating different kind of datasets, while contributing enormously to an expanding field of study in i) determining how data drawn from historical archives, natural proxies and modelling may inform respectively one another; ii) filling in a gap in research both chronologically (the first millennium of the Common Era) and geographically (the Italian peninsula) and iii) producing two new research tools useful for future studies, i.e. a repertory of 'reclaimed lands' and climatic extremes and a statistical model for climate reconstructions. Through its foci on the human responses to climate and environmental change, the project responds directly to the Horizon 2020 Work Programme to understand “the causes of climate change and to pave the way for pathways and solutions to address them”.
ARRANGEMENT AND METHOD FOR COOLING A SOLUTION

The invention relates to a cooling equipment for cooling liquid, comprising: a cooling tower that is mainly cylindrical in the vertical direction, in which case the cooling air feed equipment and the exhaust air discharge equipment are arranged, with respect to the cooling tower, so that both the cooling air flowing direction from the inlet aperture to the cooling space and the exhaust air flowing direction from the discharge equipment is horizontal and parallel to the tangent of the outer surface of the cooling tower. The invention also relates to a method for cooling liquid.
Assessment of the Role of Agricultural Cooperatives in Achieving Socio-Economic Development in Sululta Woreda, Oromia Special Zone

The study was conducted with the main objective of assessing role of Agricultural Cooperatives in achieving socio-economic development in Sululta woreda, Oromia Special Zone. Both primary and secondary sources of data were used to obtain the desired qualitative and quantitative data and semi-structured questionnaire was used to collect the necessary information. Quantitative data would analyzed by using simple descriptive statistics like percentage, frequency and mean and qualitatively .data was analyzed through concepts of explanation and elaboration of description of ideas and opinions of respondents. The result of this study shows only 14(15.2%) of the sampled respondents from the two kebeles were participant of agricultural cooperatives. The cooperative members obtained different types of services from agricultural cooperatives including agricultural input supply (92.31%).  Regarding with socio-economic challenges of agricultural cooperatives, lack of information is the main factor that affects participation of the respondents in agricultural cooperatives that accounts 85.87%.  Poor infrastructure is another factor that hinders the participation of non-participants in cooperatives as well as discourage member of cooperatives. In conclusion, agricultural cooperatives have  a great contribution for the farming community in the study area through supplying agricultural inputs i.e. improved seeds, fertilizers, and agro-chemicals with balanced price. Despite these facts, the number of participants of agricultural cooperative is small (15%).Lack of information is the main constraint that affects the participation of the respondents as mentioned by majority of study participants and key informants. Therefore, education and training program as a strategy should be designed to increase awareness about cooperatives. Keywords: cooperative, Socio-economic development, Agricultural cooperative
IL-8 RECEPTOR ANTAGONISTS

This invention relates to novel compounds of Formula (I), and compositions thereof, useful in the treatment of disease states mediated by the chemokine, Interleukin-8 (IL-8).
Musings on primordial black holes: the formation and evolution of primordial black holes and binary primordial systems

Born in the first moments of the universe, primordial black holes (PBHs) could provide the answers to many of the biggest open questions in cosmology. How did the universe begin? What is dark matter made of? PBHs are one of the oldest candidates to explain the nature of dark matter (DM), and considered by many to be one of the leading candidates — DM may be nothing more than swarms of PBHs clustered in haloes around every galaxy, and even if PBHs only make up a sub-dominant component of DM, their possible existence still has great implications not only for the evolution of the Universe, but also its creation.  It is the aim of this project to improve constraints on the primordial universe, and to determine the origin of the black holes observed by LIGO-Virgo. To achieve this, I will perform studies fitting into 3 broad categories. Firstly, the formation of PBHs and binary systems in the early universe will be studied. The results will be used to determine an appropriate window function for use when calculating the PBH abundance - eliminating the largest source of uncertainty when calculating constraints on the primordial power spectrum from PBH constraints. Secondly, small-scale simulations will be used to determine the effect of PBHs on structure formation, which will be important for determining how external forces/objects might affect the evolution of binary PBH systems. Potentially, this may also lead to observable differences in the substructure of dark matter haloes between models with and without PBHs. Finally, the formation, evolution and possible disruption of systems containing 2 (or more) PBHs (or other compact objects) will be studied, making use of results from the previous sections.
A theoretical framework towards understanding of emotional and behavioural difficulties

Children’s emotional and behavioural difficulties are the result of multiple individual, social and contextual factors working in concert. The current paper proposes a theoretical framework to interpret students’ emotional and behavioural difficulties in schools, by taking into consideration teacher–student relationships, students’ social and emotional skills and classroom context. Based on Bronfenbrenner’s bioecological model, according to which process, person and context are the main sources of children’s development, the current paper combines three theoretical approaches: firstly, in terms of process, the systems communication approach referring to teacher–students’ relationships; secondly, in terms of person, the Social and Emotional Learning, which refers to children’s social and emotional competences and skills; and thirdly, in terms of classroom context, the achievement goal theory, with emphasis on mastery classroom goal structure. The derived framework provides a means to capture the dynamic multidimensional process through which emotional and behavioural difficulties arise. This perspective provides educators with a comprehensive theoretical and practical preventative tool for emotional and behavioural difficulties.
The developmental origins and lineage contributions of endocardial endothelium

Endocardial development involves a complex orchestration of cell fate decisions that coordinate with endoderm formation and other mesodermal cell lineages. Historically, investigations into the contribution of endocardium in the developing embryo was constrained to the heart where these cells give rise to the inner lining of the myocardium and are a major contributor to valve formation. In recent years, studies have continued to elucidate the complexities of endocardial fate commitment revealing a much broader scope of lineage potential from developing endocardium. These studies cover a wide range of species and model systems and show direct contribution or fate potential of endocardium giving rise to cardiac vasculature, blood, fibroblast, and cardiomyocyte lineages. This review focuses on the marked expansion of knowledge in the area of endocardial fate potential. This article is part of a Special Issue entitled: Cardiomyocyte Biology: Integration of Developmental and Environmental Cues in the Heart edited by Marcus Schaub and Hughes Abriel.
Explainable ai pipelines for big copernicus data

DeepCube leverages advances in the fields of AI and semantic web to unlock the potential of big Copernicus data. DeepCube is impact driven; our objective is to address new and ambitious problems that imply high environmental and societal impact, enhance our understanding of Earth’s processes, correlated with Climate Change, and feasibly generate high business value. 
To achieve this we bring mature and new ICT technologies, such as the Earth System Data Cube, the Semantic Cube, the Hopsworks platform for distributed DL, and a state-of-the-art visualisation tool tailored for linked Copernicus data, and integrate them to deliver an open and interoperable platform that can be deployed in several cloud infrastructures and HPC, including DIAS environments.
We then use these tools to develop novel DL pipelines to extract value from big Copernicus data. We implement a shift in the use of AI pipelines. DeepCube 1) develops novel DL architectures that extend to non-conventional data and problems settings, such as interferometric SAR, social network data, and industrial data, 2) introduces a novel hybrid modeling paradigm for data-driven AI models that respect physical laws, and 3) opens-up the DL black box through Explainable AI and Causality. We showcase these in five Use Cases (UC), two business, two on earth system sciences, and one for humanitarian aid. These are: 
UC1: Forecasting localized extreme drought and heat impacts in Africa, 
UC2: Climate induced migration in Africa, 
UC3: Fire hazard short-term forecasting in the Mediterranean, 
UC4a: Automatic volcanic deformation detection and alerting and UC4b: Deformation trend change detection on PSI time-series for critical infrastructure monitoring,
UC5: Copernicus services for sustainable and environmentally-friendly tourism.
Portable electronic apparatus e.g. mobile telephone, support device, has fixation units integrated to buckle of belt, where each fixation unit is axially retained on plate of buckle using blocking unit

The apparatus has fixation units (12, 13) integrated to a buckle (1) of a belt (2). Each fixation unit is axially retained on a plate (3) of the buckle using a blocking unit. The plate comprises of a compartment to house electrical energy supply units e.g. rechargeable batteries, which supplies a portable electronic apparatus. The fixation units are mounted on a support plate articulated on the buckle.
Samarium-Catalyzed asymmetric radical transformations

Complex biologically-active molecules, containing linked rings of atoms and possessing elaborate 3D forms, represent the ultimate challenge for synthetic chemists. As many of society’s established and future drugs, agrochemicals, and biological probes, boast intricate architectures, the ability to efficiently generate molecular complexity from simple starting materials is vital. Radical cyclization cascade reactions could well provide the solution; they have the potential to deliver complex architectures, with control of three dimensional shape, in one-step. Unfortunately, carrying out reactions with radicals in an enantiocontrolled fashion remains challenging due to their high reactivity. This is particularly the case for radicals generated using the classical reagent, samarium(II) diiodide (SmI2). SmI2 is one of the global community’s most important and widely used reagents for radical chemistry, as evidenced by its commercial availability and its pivotal use in numerous scientific studies around the world. Despite over 40 years of widespread use, and 1000s of publications describing its chemistry, two well-known disadvantages shadow SmI2: 1. An inability to control the enantioselectivity of radical reactions using SmI2, and; 2. The requirement for the use of a significant stoichiometric excess of SmI2 thus raising issues of cost and waste.  Bringing together the Procter group’s recent breakthroughs in chiral ligand control and catalysis using SmI2, Dr Agasti’s ‘SmART’ project will develop the first catalytic enantioselective reactions using SmI2. Furthermore, the new catalytic processes will be used to convert simple feedstocks into high-value, complex, cyclic molecules bearing multiple stereocenters with high enantio- and diastereocontrol. Previously, such molecules could only be prepared by laborious multi-step synthesis. Dr Agasti’s approach will therefore streamline complex molecule synthesis, saving time and money, and minimizing chemical waste.