SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Reverse-Engineering the development of embryos with physics-informed machine learning

Embryogenesis is archetypal of a self-organized process, where the emergence of a complex structure stems from the interaction of its elementary parts. Progress in imaging and molecular genetics allow us to delve into embryos at unprecedented spatiotemporal resolutions, but extracting biophysical information from this complex multidimensional data is a highly technical challenge. As a result the principles of multicellular self-organization remain far from understood. DeepEmbryo proposes to fill this gap by pioneering the use of deep learning to reverse-engineer early embryo development directly from high-resolution 3D microscopy movies. Focusing on four animal groups (mammals, ascidians, nematodes and annelids), the project will combine physical modeling and machine learning to tackle three fundamental questions from a unique transversal perspective: Q1 What are the forces shaping early embryos? Using convolutional neural networks, I will develop an automated method to directly infer cell forces from membrane-labeled images of embryos. Q2 How do cells coordinate forces, division and signaling? Regarding cells as dynamical systems, I will model them with minimal neural networks and design a multi-agent embryo model able to learn by reinforcement the fundamental feedback controls between mechanics and fate. Q3 What principles ensure developmental robustness? Using deep generative models, I will infer intra-specie developmental variability to identify robust developmental traits and mechanisms. Using dropout techniques as virtual analog to genetic knockout, I will produce experimentally testable new predictions, refining my inaugural virtual embryos. Pioneering a new field at the frontier of developmental biology, artificial intelligence and physics, DeepEmbryo will uncover the fundamental engineering principles of early embryogenesis, with far-reaching implications in multi-agent modeling, evolutionary biology, physical inference and tissue engineering.
A family of Full-Bridge Single-Stage PFCs topologies: Identification of technical problems

In order to provide AC-DC conversion and power factor correction (PFC), Full-Bridge Single-Stage (FBSS) topologies are the most popular for high performance converters with power levels above 500W. Their behaviour and features are in general well defined and analysed. However, these topologies may introduce several complex operating limits and control problems that are not yet described in literature. This is mainly due to the fact that these limitations devaluate and restrict the number of applications. The most concerning problems are identified as: transformer primary saturation and output voltage perturbations. Wide load range variation can also be considered a complex issue because it leads to uncontrollable circuit variables, namely, input current and DC bus voltage. With the objective of clarification, this paper analyses in detail the referred technical problems considering their impact in the FBSS topologies operation and presents design criteria and control solutions to minimize their effects. Experimental results are presented to verify the theoretical concepts.
POSITIONER, GUIDE AND/OR MAGAZINE FOR SCREWS AND NAILS

An aspect of some embodiments of the current invention relates to a positioner for holding one or more fasteners (e.g. screws and/or nails) which allows a user to push the fasteners out directly into a target material. For example, a user may locate the positioner over a location on the target material and/or drive the fastener through the positioner into the target. In some embodiments, the positioner includes multiple fasteners, for example the positioner maybe used as a magazine of fasteners and/or a storage box for fasteners. Optionally, the positioner includes a hard frame and/or a soft passage holding the fastener. For example, a fastener is inserted into the top of the passage and driven (e.g. pushed, hammered and/or screwed) through, out the bottom of the passage into the target. Optionally, multiple positioners may be arranged along a guide.
A detection device where a single measured value delivered which lies within a first and second measurement range corresponds to an actual measurement

The present invention relates to a detection device comprising means 3 able to measure the value of a parameter, said device 1 being able to deliver values lying within a first measurement range which is limited at least by a first limit value. According to the invention, this device 1 furthermore comprises means 5 for modifying before delivery thereof any measured value so as to deliver a corresponding value which is defined in a second measurement range, said second measurement range being limited by at least a first limitation value which is different from said first limit value and which forms part of said first measurement range.
Hermes - high efficiency real-time multithreading engine for space applications

Software development for the aerospace industry is currently performed with a number of proprietary solutions, all of them expensive and based mainly in computer technologies created 25 years ago. It misuses available resources and causes inefficiency on issues such as satellite data acquisition planning and satellite data processing.
HERMES is a software development kit targeting the Space Industry, which permits developing complex software systems at a fraction of cost and schedule, while providing competitive advantages in performance and visualization. It proposes a complete renewal of the core software used to manage satellite data acquisition functions through innovative methods of general purpose GPU processing, incorporating much of the latest innovations in hardware and software, in particular as regards visualization and processing with graphic hardware. We provide breakthrough innovations in this area, completely developed by us. With them, we achieve a proved increment in data processing speeds in the range 10x-100x, redounding in strong savings in time, money and power consumption. 
There is a big opportunity for HERMES, now and over the next 20 years, in view of the rapid growth of the Space Industry, especially the private sector, and considering client feedback received. Our target market is professional builders of software systems, either integrating HERMES in their development or by commissioning the development to us. In either case, the advantages provided by HERMES will justify the expenses incurred. We believe there is a sustainable business case through sales of HERMES licenses, maintenance support, and customized bespoke developments.
HERMES project will be implemented by TAITUS, an SME with 12 years of experience providing software solutions to the space sector and owner of SaVoir, a leader multi-satellite swath planner used in over 25 countries by all major space agencies and aerospace companies.
Perfectionistic Automatic Thoughts, Trait Perfectionism, and Bulimic Automatic Thoughts in Young Women

The current research examined the associations among perfectionistic automatic thoughts, trait perfectionism, negative automatic thoughts, and bulimic automatic thoughts. A non-clinical sample of 94 undergraduate women completed the Perfectionism Cognitions Inventory, the Multidimensional Perfectionism Scale, the Automatic Thoughts Questionnaire, and the Bulimic Automatic Thoughts Test. Correlational tests revealed that two automatic thoughts measures (perfectionistic automatic thoughts and negative automatic thoughts) and two trait perfectionism measures (self-oriented and socially prescribed perfectionism) were associated significantly with bulimic automatic thoughts with the strongest association being between perfectionistic automatic thoughts and bulimic automatic thoughts. Regression analyses showed that perfectionistic thoughts predicted unique variance in bulimic thoughts beyond variance attributable to trait perfectionism and negative automatic thoughts. The findings are discussed in terms of the need to incorporate an explicit focus on perfectionistic automatic thoughts into treatment interventions and conceptual models of perfectionism and eating disorders.
High flux high efficiency nanofiber membranes and methods of production thereof

A membrane is provided including a coating layer having cellulose nanofibers produced from oxidized cellulose microfibers and an electrospun substrate upon which the coating layer is applied. The nanofibers of the electrospun substrate have a diameter greater than that of the cellulose nanofibers. The membrane also has non-woven support upon which the electrospun substrate is disposed. Microfibers of the non-woven support have a diameter greater than that of the nanofibers of the electrospun substrate. Application of electrospun membrane is in microfiltration area, while the cellulose nanofiber membrane serves in ultrafiltration, nanofiltration, and reverse osmosis after chemical modification.
Why are names of people associated with so many phonological retrieval failures?

Two experiments are reported that revisit the issue of why people's names are more difficult to recall than common names such as the names of objects. In Experiment 1, retrieval of the names of a set of object pictures was compared with recall of a set of names of famous faces. The object and face sets were matched for preexperimental familiarity. The results showed significantly more tip-of-the tongue (TOT) states and significantly poorer name recall for faces than for objects. Although the overall numbers of incorrect answers for the two sets of items did not differ, the incorrect answers in the face condition were mostly "don't know" responses, whereas incorrect answers for objects were mostly alternative names. In Experiment 2, written definitions were used instead of pictures, and target items were selected so as to keep the number of alternatives to a minimum. Under these circumstances, there were no differences in either the number of items correctly named or the number of TOTs for common and people's names. These findings are consistent with the views of Brédart (Memory, 1, 351-366, 1993), who argued that there are fewer documented TOTs for common names because a semantically related alternative often comes to mind when a participant is experiencing, or is about to experience, a retrieval failure.
The contribution of experimental volcanology to the study of the physics of eruptive processes, and related scaling issues: A review

Abstract The experimental approach has become a major tool increasingly used by volcanologists in recent decades to investigate the physics of eruptive processes in complement to field and theoretical works. Researchers have developed various methodologies to study volcanic phenomena at reduced length scale. The works involve natural or analogue materials and their types range from first-order tests, to identify fundamental processes and make qualitative comparison with field observations, to more sophisticated experiments in which precise data obtained in a controlled environment can be used to validate outputs of theoretical models. Scaling is a central issue to ensure dynamic similarity between the small-scale experiments and the large-scale volcanic phenomena when natural conditions cannot be simulated due to inherent length scale difference and/or technical limitations. In this respect, dimensionless numbers are used to map physical regimes and to define scaling laws, which allow experimental results to be extrapolated to natural scale. This review presents the variety of experimental studies conducted to investigate subterraneous and aerial volcanic phenomena involving in particular fluid-particle mixtures. We focus on the major scaling issues and the physical regimes investigated, and we also highlight in a historical perspective some of the major advances achieved through experimental studies. Finally we conclude on some perspectives for future works.
Adriatic Identity through Development of Arts

AIDA wants to show that it is possible to consider the entire program area (Ita Alb Mon) from a single point of view, highlighting the many points of contact that exist between the citizens and the communities of the different territories involved. AIDA will create an Adriatic Identity Model based on memory awareness of the communities. The model will be develop along two paths: a desk research (with scientific purpose) and a field research (for a specific work with community through arts tool). The project will create local community networks in the cities of Lecce, Campobasso, Tirana and Ulcinj that will later be put together with the aim of creating a crossborder network of communities in the Adriatic area. The cities will be “pilot cities” in a perspective of development and follow-up of the project that aims to transfer this model to other cities and to map the entire program area. In each city, artistic projects will be carried out that will actively involve the entire community and all stakeholders. These activities will consider an in-depth work to recover the memory of the community and of the cities through storytelling and performing activities. The results from each city will be transformed into a single work of contemporary art: an original theatrical production that will involve artists from all areas. All activities will be closely connected to abandoned and forgotten places that are a symbol of the lost memory of the cities and of citizens. The project will enhance these forgotten places in terms of tourism through specific cultural and environmental actions involving communities and stakeholders. Project will improve the area by planting some trees chosen by the communities. The model of the project it is, as well, a brand building because it is exactly an innovative way to be part of artist and community project: PEOPLE, PLACES AND TREES, is a clear claim that would be a way for audience and tourism development.
Era-Net cofund on ict-enabled agri-food systems

This proposal responds to topic “SFA-31-2019 A” of the work programme 2018-2020 of societal challenge 2 under Horizon 2020. The overall objective of “ICT-enabled agri-food systems” is strengthening the cooperation in research, development and innovation between EU Member and associated States to foster, verifiably and perceptibly, the use of smart digital technology to make European food systems more sustainable, resilient and secure.
With financial support of the European Commission (EC), the proposing consortium will organise and fund joint calls for transnational research projects on an annual basis. Funded research projects will contribute to introducing and exploring digital technology that enhances the sustainability of the agri-food sector to the benefit of our and future generations. Beyond co-funded calls, other joint activities in this thematic area will be implemented, thus contributing to the establishment of a fair and societally accepted bioeconomy in the EU and beyond. The consortium will intensify, broaden and deepen the successful cooperation established in the framework of its predecessor FP7 ERA-NET; ICT-AGRI-2.
Multiscale modeling and simulation of soft adhesion and contact of stem cells

Recently, we have developed a multiscale soft matter model for stem cells or primitive cells in general, aiming at improving the understanding of mechanotransduction mechanism of cells that is responsible for information exchange between cells and their extracellular environment. In this paper, we report the preliminary results of our research on multiscale modeling and simulation of soft contact and adhesion of cells. The proposed multiscale soft matter cell model may be used to model soft contact and adhesion between cells and their extracellular substrates. This model is a generalization of the Fluid Mosaic Model (Singer and Nicolson, 1972), or an extension of Helfrich's liquid crystal membrane model (Helfrich, 1973). To the best of the authors' knowledge, this may be the first time that a soft matter model is developed for cell contact and adhesion. Moreover we have developed and implemented a Lagrange type meshfree Galerkin formulation and the computational algorithm for the proposed cell model. Comparison study with experimental data has been conducted to validate the parameters of the model. By using the soft matter cell model, we have simulated the soft adhesive contact process between cells and their extracellular substrates. The simulation shows that the cell can sense substrate elasticity by responding in different manners from cell spreading motion to cell contact configurations.
Characterizing gene regulation in single cells through integration of scrna-seq and scatac-seq data with generic multi-modal prior information

The advent of single cell technologies has enabled the characterization of cell types and developmental processes. Observations from different cells allow one to identify underlying patterns at higher resolution than convoluted bulk data, and integration of different omics data can yield a more differentiated picture of mechanistic connections. In this proposal, Gene REgulatory Cell States (GReCS) from multi-modal data, I plan to develop a computational method that combines these aspects to generate insights into gene regulation at the level of single cells.

Measurements of chromatin accessibility in single cells are becoming increasingly common. The method I propose to develop combines sc/sn-ATAC- and scRNA-sequencing data to characterize gene regulation. My approach will integrate and use transcriptomics and open chromatin data to filter comprehensive prior information about candidate interactions and predict cell-specific gene regulatory network versions using machine learning, while sparse single cell measurements are imputed using local cell similarities. In this way, rare measurements across cell types and a larger condition space for network inference can be exploited, using the natural potential of chromatin accessibility data as a filter to map interactions into a cell-specific context.

A distinguishing feature of the proposed method is the characterization of local gene regulatory states, which allows the observation of continuous changes throughout a cell-cell similarity embedding. This will be useful to examine changes during cell differentiation and along gradients in spatial reconstructions, for example of embryonic development. The developed methods will be made available to the community as a computational toolkit to improve the characterization of gene regulation by combining different types of data.
Italian-Slovene ecosystem for electronic and mobile health

The goal of ISE-EMH (Italian-Slovene Ecosystem for Electronic and Mobile Health) is to extend and improve the e-health and mobile health project, part of the EcoSMART project http://ekosmart.net/it/about/. The value of the latter project is 8.66 million euros. It is a three-year-project ending within 6 months. Its results are already very evident: a distributed ecosystem of services, systems and data. Some of them are integrable or usable in other systems. The emphasis is on EMH services. The EMH ecosystem will be extended to improve Slovene backbone,by using Italian skills in medical field and ICT and through cross-border knowledge transfer to create an improved EMH ecosystem. It will allow cooperation in participant Italian and Slovenian regions: Industry will gain access to innovative solutions developed by the academic world. Academia advanced research will be validated and capitalized in production environments. Patients will have access to available innovative healthcare services and applications, some for free and some upon payment. Hospitals will be connected to their patients through ICTs to give them access to patient data in a secure and easily accessible way. Elderly will gain remote home assistance. Healthcare Providers e developers will offer easy use and promotion of innovative solutions, through direct connection with end users. The ecosystem will be validated with at least 6 applications within the EMH ecosystem
developed.
EFFECTS OF NEPOTISM AND FAMILY CONFLICTS ON THE PERFORMANCE OF

Drawing on the agency theory and stewardship perspective, this article examines the extent to which nepotism and family conflicts affect the performance of family-owned firms in Tanzania. From a sample of 163 family firms and the Structural Equation Model (SEM) results, our article indicates that nepotism and family conflicts have no significant negative effect on both the financial and market-based performance of family firms. Contrary to previous studies which report that nepotism and family conflicts are detrimental to firm performance, this article demonstrates that the small family-owned firms operating in a developing economy with an inadequate institutional environment are better off engaging committed and productive staff from those with a common family background and culture. While our article supports the stewardship perspective regarding family enterprises, it indicates the need for further investigation into the impact of family characteristics on firm performance given the differing views that exist in the academic literature.
Dynamics and diversity of the ‘Atopobium cluster' in the human faecal microbiota, and phenotypic characterization of ‘Atopobium cluster' isolates

This study monitored the dynamics and diversity of the human faecal ‘Atopobium cluster’ over a 3-month period using a polyphasic approach. Fresh faecal samples were collected fortnightly from 13 healthy donors (six males and seven females) aged between 26 and 61 years. FISH was used to enumerate total (EUB338mix) and ‘Atopobium cluster’ (ATO291) bacteria, with counts ranging between 1.12×1011 and 9.95×1011, and 1.03×109 and 1.16×1011 cells (g dry weight faeces)−1, respectively. The ‘Atopobium cluster’ population represented 0.2–22 % of the total bacteria, with proportions donor-dependent. Denaturing gradient gel electrophoresis (DGGE) using ‘Atopobium cluster’-specific primers demonstrated faecal populations of these bacteria were relatively stable, with bands identified as Collinsella aerofaciens, Collinsella intestinalis/Collinsella stercoris, Collinsella tanakaei, Coriobacteriaceae sp. PEAV3-3, Eggerthella lenta, Gordonibacter pamelaeae, Olsenella profusa, Olsenella uli and Paraeggerthella hongkongensis in the DGGE profiles of individuals. Colony PCR was used to identify ‘Atopobium cluster’ bacteria isolated from faeces (n = 224 isolates). 16S rRNA gene sequence analysis of isolates demonstrated Collinsella aerofaciens represented the predominant (88 % of isolates) member of the ‘Atopobium cluster’ found in human faeces, being found in nine individuals. Eggerthella lenta was identified in three individuals (3.6 % of isolates). Isolates of Collinsella tanakaei, an ‘Enorma’ sp. and representatives of novel species belonging to the ‘Atopobium cluster’ were also identified in the study. Phenotypic characterization of the isolates demonstrated their highly saccharolytic nature and heterogeneous phenotypic profiles, and 97 % of the isolates displayed lipase activity.