SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Disruption of systemic and microenvironmental barriers  to immunotherapy of antigenic tumors

The frontier in cancer therapy of orchestrating the immune system to attack tumors is producing unprecedented survival benefit in some patients. The corollary is lack of efficacy both in ostensibly responsive tumor types as well as others that are mostly non-responsive. The basis lies in pre-existing and adaptive resistance mechanisms that circumvent induction of tumor-reactive cytotoxic T cells (CTLs) capable of infiltrating solid tumors and eliminating cancer cells. A priori, cancers induced by expression of human papillomavirus oncogenes should be responsive to immunotherapy: these cancers encode immunogenic neo-antigens – the oncoproteins E6/7 – necessary for their manifestation. Rather, such tumors are poorly responsive to immunotherapies. Results from my lab and others using mouse models of HPV-induced cancer have established an actionable hypothesis:  during tumorigenesis, such tumors erect multiple barriers to the induction, infiltration, and killing of cancer cells by tumor antigen-reactive CTLs. These include overarching systemic antigen-nonspecific immunosuppression mediated by expanded populations of myeloid cells in spleen and lymph nodes, complemented by immune response-impairing barriers operative in the tumor microenvironment. A spectrum of models will probe these barriers, genetically and pharmacologically, establishing their functional importance, alone and in concert. A major focus will be on how oncogene-expressing keratinocytes elicit a marked expansion of immunosuppressive myeloid cells in spleen and lymph nodes, and how these myeloid cells in turn inhibit development and activation of CD8 T cells and antigen-presenting dendritic cells.  Then we’ll assess the therapeutic potential of barrier-breaking strategies combined with immuno-stimulatory modalities.  This project will deliver new knowledge about multi-faceted barriers to immunotherapy in these refractory cancers, helping lay the groundwork for efficacious immunotherapy.
Online estimation of atmospheric turbulence parameters and outer-scale profiling

Estimating the outer scale profile, L0(h) in the context of current very large and future extremely large telescopes is crucial, as it impacts the on-line estimation of turbulence parameters (Cn2(h), r0, θ0 and τ0) and the performance of Wide Field Adaptive Optics (WFAO) systems. We describe an on-line technique that estimates L0(h) using AO loop data available at the facility instruments. It constructs the cross-correlation functions of the slopes of two or more wavefront sensors, which are fitted to linear combinations of theoretical responses for individual layers with different altitudes and outer scale values. We analyze some restrictions found in the estimation process, which are general to any measurement technique. The insensitivity of the instrument to large values of outer scale is one of them, as the telescope becomes blind to outer scales larger than its diameter. Another problem is the contradiction between the length of data and the stationarity assumption of the turbulence (turbulence parameters may change during the data acquisition time). Our method effectively deals with problems such as noise estimation, asymmetric correlation functions and wavefront propagation effects. It is shown that the latter cannot be neglected in high resolution AO systems or strong turbulence at high altitudes. The method is applied to the Gemini South MCAO system (GeMS) that comprises five wavefront sensors and two DMs. Statistical values of L0(h) at Cerro Pachon from data acquired with GeMS during three years are shown, where some interesting resemblance to other independent results in the literature are shown.
Induced genetic variability, heritability and genetic advance in sesame (Sesamum indicum L.).

Three widely adapted sesame genotypes Rama, SI 1666, and IC 21706 were induced by 200 Gy, 400 Gy, and 600 Gy doses of γ rays as well as by 0.5%, 1.0%, 1.5%, and 2.0% concentrations of ethyl methane sulfonate (EMS) separately. Mutant generations from M1 to M2 were raised to assess the extent of variability, heritability, and genetic advance for yield and important yield components in mutant populations. Mutations surpassed the magnitude of variability over the control population in both generations. Mutagenic treatments caused a shift in the mean values of quantitative traits in both positive and negative directions, albeit the magnitude of the shift varying with mutagen, its dose, parental genotype, and character under consideration. Lower doses of mutagens were more proficient for induction of mutations. The chemical mutagen (EMS) was much more effective than the physical mutagen (γ rays) in producing polygenic variability. The genotype IC 21706 and the treatment using 0.5% concentration of EMS appeared to be the best for engendering variability, highlighting their potentiality for selecting higher yielding plants in early generations. In the M2 generation, there was considerable increase in genetic estimates for all the metric traits, as compared with that in the M1. In general, estimates of genetic variability and heritability dwindled with increasing doses of γ rays and EMS. All genotypes showed a promising increase in genotypic variability, heritability and genetic advance for all traits, implying that these characters can be transmitted to future generations. This means that a significant gain could be achieved through selection in early generations.
LIQUIFIED MATERIAL SQUEEZING METHOD AND APPARATUS FOR OIL AND GAS WELLS

Method and apparatus for melting a material and squeezing the melted material through casing perforations into a fault within the cement or formation of an oil or gas well. A heating tool carries solid material which is melted at depth within the well and adjacent to the casing perforations. The liquefied material is forced through the perforations and into the formation or the well cement. When the material cools and solidifies, the faults become sealed.
Secure and wireless multimodal biometric scanning device for passenger verification targeting land and sea border control

Every year a large number of visitors enter the European Union (EU) by cars, buses, trains or ships through land-border crossing points or sea ports bringing significant economic benefits; in particular, 9% of Europe’s GDP comes from tourism. This trend is set to continue, as Europe further considers visa liberalization agreements in a bid to sustain their competitive stance in the global tourism market. This will create major implications on the security and border management in the EU, as well as diminishing the Quality of Experience for passenger travel.  
Existing directives for controlling border crossing is to conduct checks using biometric data in conjunction with VIS (Visa Information Systems), as specified in the Schengen Border Code. However, current biometric systems rely on one mode of biometric data, that can at times can lead to false identification, in particular under uncontrolled conditions during live sample acquisition. Moreover, the current crop of scanning devices are limited in coverage and typically have fixed links, thus confining the range of border control applications and compromising the comfort of passengers. We aim to go beyond and propose an innovative passenger-centric biometric system that authenticates “on the fly”. We combine the scientific field of wireless security, biometric recognition and data fusion to develop a  secure and wireless multimodal biometric scanning device for passenger verification targeting land and sea border control applications. 
The research approach is the basis for a RISE training action that we refer to as eBORDER, that is foreseen to enhance both the career potential of staff members and innovation capacity at the institutional level. In this context, this action brings together key players from industry and academia with complementary expertise on security, biometrics, data fusion and practical experimentation to train staff by research through intersectorial and international staff exchanges.
Schur Polynomials and The Yang-Baxter Equation

We describe a parametrized Yang-Baxter equation with nonabelian parameter group. That is, we show that there is an injective map \({g \mapsto R (g)}\) from \({ \rm{GL}(2, \mathbb{C}) \times \rm{GL}(1, \mathbb{C})}\) to End \({(V \otimes V)}\) , where V is a two-dimensional vector space such that if \({g, h \in G}\) then R12(g)R13(gh) R23(h) = R23(h) R13(gh)R12(g). Here Rij denotes R applied to the i, j components of \({V \otimes V \otimes V}\) . The image of this map consists of matrices whose nonzero coefficients a1, a2, b1, b2, c1, c2 are the Boltzmann weights for the non-field-free six-vertex model, constrained to satisfy a1a2 + b1b2 − c1c2 = 0. This is the exact center of the disordered regime, and is contained within the free fermionic eight-vertex models of Fan and Wu. As an application, we show that with boundary conditions corresponding to integer partitions λ, the six-vertex model is exactly solvable and equal to a Schur polynomial sλ times a deformation of the Weyl denominator. This generalizes and gives a new proof of results of Tokuyama and Hamel and King.
Integrating physiological responses into species distribution models to forecast the effects of future ocean warming and oxygen depletion on fish larvae dynamics

Assessing the effects of climate change in larval ecology is fundamental to predict the future of fish stocks and fish diversity since connectivity among fish populations depends on larval distribution patterns. To forecast these effects on larvae is challenging because each species exhibits specific responses to ocean warming and O2 depletion by improving physiological performance to adapt or shifting dispersal features to preserve climatic niche. Thus, FUTURELARVAE will incorporate physiological responses to rising temperature and O2 depletion into SDMs to mechanistically forecast the future distribution of fish larvae aiming at understanding the magnitude at which climate change will affect the suitability of present vs. future habitats for larvae that exhibit different functional guilds (pelagic vs. demersal) and life history strategies (short vs. long pelagic duration). Experimental biology will be used to produce eco-physiological data representing the larval response to present and future scenarios of climate change. These data will be integrated into SDMs using Bayesian GLMs in order to understand whether these life history strategies will succeed under future climate conditions. For this, experts in environmental computational science (ER), experimental biology (supervisor) and eco-physiology modelling (advisor) will exchange knowledge and complement each other’s know-how. The ER will gain new technical skills on analytical tools, processing of mechanistic models and apply tools to generate science-based advice for the conservation of marine resources. By the end of the MSCA-IF, the ER will have acquired transferable skills in scientific management, leadership, science dissemination/communication and stakeholder engagement and have broaden his network, boosting his career. The ER will acquire much-needed conceptual/technical skills that are in high demand during this UN decade of the Oceans and commitment to SDG14, increasing his employment opportunities.
The Production of Urban Space by Violence and its Aftermath in Jakarta and Kota Ambon, Indonesia

Violence has an enormous potential impact on the production of urban space. This article presents an analysis of how violence has made an impact on Indonesian cities since 1998. Using case material from communal violence in Kota Ambon, and lynching and vigilantism in Jakarta, the article addresses the question what impact did violence have on the spatial restructuring of some Indonesian cities and, conversely, – assuming that the people who used violence are slowly relinquishing its use – what impact does the restoration of law and order have on urban space? How enduring are some of the underlying, historical patterns of violence and do many of them still exist, hidden under the surface, today?
Low-Cost led headlamp system for increased safety, efficiency and sustainability in automotive lighting

As LED lighting becomes more mature and affordable, it is increasingly used in a broad range of lighting applications. This includes automotive lighting: LEDs are already widely used for interior lighting and signal functions such as parking lamps, brake lamps and turn signals as well as daytime running lamps. LEDs are, however, still rarely used in headlamps, despite its advantages in terms of safety and environmental impact; and despite the fact that it represents the single largest market opportunity within automotive lighting. One of the major reasons for this apparent paradox is the cost for the automakers to implement them at a price the consumer is willing to pay. Hungaro Lux Light is developing is a novel optical system for motor vehicle headlamps, designed specifically for LED light sources. Our solution uses only refractive elements, resulting in better optical efficiency and far lower manufacturing costs than current solutions, making LED headlamps economically feasible across all vehicle classes. Increased use of LED headlamps will have considerable benefits both for the end-users and for the society at large: cost and energy savings; reduced environmental impact and better road safety. This proposal aims a Phase 1 project to define the optimal technological roadmap and commercialisation strategy for the successful market introduction of the LEDHEAD technology.
Combined action filter press

The present invention concerns a filter press (10, 60), comprising a supporting frame, constituted of at least one longitudinal rail or guide (11, 61) supported at its opposite ends by a fixed headpiece (12, 62) on one side and by a foot (13, 63) on the other side, a movable headpiece (15, 65) supported by said at least one guide (11, 61), a plurality of filtering plates (14, 64) arranged side by side between said fixed headpiece (12, 62) and said movable headpiece (15, 65), pneumatic elements or cushions (20, 70) for pressing and a compression plate (21, 71), wherein said movable headpiece (15, 65) comprises threaded cylindrical holes, supported on relative endless screws (19, 69) the ends of which are rotationally mounted on supports integral with the relative guides (11, 61).
The dawn of writing in western mediterranean: a comparative approach to the iberian epigraphic corpus

This project proposes a study of all known Iberian inscriptions (about 2.000 documents dating from the 5th century BC to the 1st century AD) in a comparative and interdisciplinary perspective. The study of the Iberian corpus will be set in a broad cultural context, including the rise of the first Western written traditions and their linguistic and cultural contacts. I will focus on issues such as the relationship between text and object, the Iberian adoption of exogenous epigraphic models (mainly Phoenician/Punic, Greek and Latin), and the level of literacy within the male and female spheres of this society.
 
Although the Iberian language in not yet fully deciphered, its epigraphic texts represent a cornerstone of the ethnological and cultural understanding of the protohistoric peninsular peoples and their insertion within the Mediterranean world. For the time being, however, there is no comprehensive study of the Iberian corpus, which has grown considerably over the past decades. On the other hand, there has been a tendency to study the Iberian world and its written culture in an overly isolated way, without sufficiently considering the panorama of neighbouring territories, which provide significant parallels. 

The specific objectives of this project can be synthetized as follows: publication of the entire corpus of Iberian inscriptions according to current academic criteria, including a digital open access version; linguistic analysis of these texts with a special attention to the cultural context in which they were produced; study of the Iberian written culture in a broad cultural context, including neighbouring territories such as Northern Africa. This project will therefore contribute to the understanding of the Iberian language as well as the circulation of cultural models within the Western Mediterranean. It will ultimately represent an innovative step toward the comprehension of the birth of European identities.
ν¯linduced pion production from nuclei at∼1 GeV

We have studied charged current $\bar\nu_l$ induced one pion production from $^{12}$C and $^{16}$O nuclear targets at MiniBooNE and atmospheric antineutrino energies. The calculations have been done for the incoherent pion production process as well as for the pions coming from the hyperons in the quasielastic production of $\Lambda$ and $\Sigma$. The calculations are done in the local density approximation. For the inelastic processes the calculations have been done in the $\Delta$ dominance model and we take into account the effect of Pauli blocking, Fermi motion of the nucleon and renormalization of $\Delta$ properties in the nuclear medium. The effect of final state interaction(FSI) of pions is also taken into account. For the hyperon production, the nuclear medium effects due to Fermi motion and FSI effects due to hyperon-nucleon scattering have been taken into account. These results may be quite useful in the analysis of SciBooNE, MicroBooNE, MINER$\nu$A, and ArgoNeuT experiments when the pion analysis is done by using antineutrino beams.
Strategic Hubs for the Analysis and Acceleration of the Mediterranean Solar Sector

The project in brief _x000D_
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The last decades have witnessed a growing interest for solar energy initiatives in the Mediterranean region, coupled with a growing pressure to ensure an actual shift from traditional energies towards a more efficient energy system. While many successful national and regional projects have been implemented in order to develop market, policy and technical actions, the transition to solar energy needs to be supported by a comprehensive and unified process at Mediterranean level. _x000D_
As a response to this challenge, SHAAMS aims to raise public awareness on energy efficiency through the transferability and implementation of good practices in legal, regulatory, economic, organizational issues and new financing mechanisms, in order to facilitate the take up of solar technologies in Mediterranean countries. _x000D_
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Specific objectives_x000D_
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• To establish efficiency-proven governance solutions aimed at identifying innovative, transferable and sustainable solar energy strategies _x000D_
• To promote a cultural, behavioural and operational change towards the success of solar energy-driven solutions _x000D_
• To facilitate the transfer of solar technologies by implementing shared mechanisms and procedures
Implication of anthropometric profile and alimentary consumption on risk for diseases among school children in the 1st to 4th grades

This study aimed to determine the anthropometric profile and diet of 652 school children from the 1st to 4th grades of elementary education in six private schools in the city of Maringá, Paraná, Brazil. Children's weight and height were classified according to the Body Mass Index proposed by Must et al. (1991). Food consumption was evaluated by means of a questionnaire about daily food frequency. Statistical analysis was carried out using linear and logistic regression tests, with a significance level of 5%. High rates of overweight and obesity, 21.9% and 13.3% respectively, were observed, which did not show a significant relationship with total food consumption. The data obtained were: high consumption of foods rich in energy, such as sugar- and fat-rich foods, and insufficient consumption of low-energy foods that are sources of micronutrients, such as vegetables. It is necessary to enhance the promotion of good alimentary and health habits within schools to lower risk factors for developing diseases, as well as to develop and validate a questionnaire to reliably assess the diet of the infant population.
Wireless Network Behavior under ICMP Ping Flood DoS Attack and Mitigation Techniques

Internet Control Message Protocol (ICMP) is an erro r reporting and diagnostic utility and it is consider ed as a part of Internet Protocol (IP) suite. Although this protoco l is very important for ensuring correct data distribution, i t can be exploited by malicious users for conducting different Denial of Service (DoS) attacks. Due to the broadcast nature of wireless co mmunication, exploitation of this kind of attack is even easier. By sending bogus ICMP redirect packets, a malicious user can either disrupt or intercept communication from a wireless access poin t. In this paper, we present our approach to simulate the ICMP Ping Flood Attack, and to analyze the effects of th is attack on wireless networks using OPNET Modeler. We propose several countermeasures against this type of attack. Simula tion results regarding the effects of link failure recovery mech anism against this type of attack are discussed .
Formulations and computational engineering

The FORCE consortium is a 10 pan-European expert partnership with the objective to develop a integrated Business Decision Support System (BDSS) based on open standards for industries engaged in formulating chemical ingredients.  The generic BDSS is an open framework that connects any existing or future materials models at various levels of complexity and discretion (electronic, atomistic, mesoscopic, continuum and empirical), experimental data sets, and structured and unstructured commercial information (e.g. on cost, forecasting, intellectual property (IP)). In combination with multi-criteria (objective) optimizers (MCO) for key performance indicators (KPI’s) the BDSS generates data driven formulation and product options for facilitating business decision making.  The project has a generic focus but targets 3 specific important industrial sectors as main demonstrators, namely Personal Care (liquid detergents), Insulating Rigid PolyUrethane (PU) based Foams and Industrial Inks (PU-based) for the purpose of focus and generating a real ready to use BDSS available to large, medium and small enterprises alike. The proposed options are tailored for use into problem specific Apps. These provide an additional level of tailored user-friendliness and a data driven operational tool for product optimization, development and quality checks including faster and tailored customer services for the formulators and the providers of formulation components. Accordingly the project is positioning materials modeling as an integrated part of a business decision process. The consortium strives to change the modus operandi of mainly empiricism-based formulation industries into a science and technology and data driven industry by taking advantage of materials modelling and advanced computational learning methodologies for handling “big data”. The partners subscribe to the activities of the European Materials Modelling Council (EMMC).