SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Regulation and function of endocrine-specific splicing programs in pancreas and their role in diabetes

Pancreatic beta cells are highly specialized cells that play a key role in maintaining glucose homeostasis by secreting insulin. Dysfunction or loss of beta cells results in diabetes, a worldwide growing epidemic. Extensive research has started to uncover the signals and transcriptional networks that control specification, differentiation and maturity of the different pancreatic cell lineages, and in particular of beta cells. However, posttranscriptional regulation during pancreas development has remained mostly unexplored. Alternative splicing (AS) is the main posttranscriptional mechanism that generates transcriptomic and proteomic diversity, playing essential roles in cell specification and functional specialization. My previous data suggest that beta cells activate neuron-related splicing programs involved in the regulation of insulin secretion. Moreover, pro-inflammatory cytokines (mediators of beta cell failure in type 1 diabetes) affect the splicing of signaling and pro-apoptotic genes that determine beta cell survival. However, the presence of beta- or endocrine-specific splicing programs and their role in diabetes remains to be clarified. In this project, we will investigate the regulation and function of endocrine-specific alternative exons. I will combine comparative transcriptomics, biochemical and functional studies, iPCS reprogramming and zebrafish knock-outs to: (i) comprehensively identify endocrine-AS exons, and study their regulation during beta cell differentiation and pancreas development; (ii) probe the phenotypic impact of endocrine-AS programs on beta cell differentiation and function; and (iii) Investigate the role of ENDO-AS exons in remodeling transcriptional and signaling networks involved in diabetes. We foresee that this project will provide new insights into beta cell pathophysiology and generate valuable knowledge for the development of splicing-modulating therapies and disease biomarkers.
Different exposure of infants and adults to ultrafine particles in the urban area of Barcelona

Air pollutants have been linked with a number of adverse health effects. Children are especially sensitive, particularly when they get close to the exhaust emissions of the vehicles on the street. The objective of this study was to measure the different exposure of infants and adults to ultrafine particles (UFP) as a surrogate marker of air pollution and of risk of deleterious health effects. Two different portable P-TRAK® were used to measure simultaneously exposure to UFPs at different heights, one corresponding to the height of an infant in a stroller (0.55 m) and the other one to the height of the face of an adult pedestrian (1.70 m). Measurements were taken on three different streets with high traffic density in Barcelona, in 10 consecutive days during spring, with two sampling sessions of 1 h each day, moving afoot and taking into account temperature, humidity, and wind speed. Fifty-two thousand and eight (52,008) paired values were obtained, and the results showed about 10 % higher levels of UFP concentration at 0.55 m (48,198 ± 25,296 pt/cm3) compared to 1.70 m (43,151 ± 22,517 pt/cm3). Differences between working and nonworking days were observed. Concentration patterns and variation by days of the week and time periods were related to traffic intensity. This study revealed that infants transported by stroller in urban areas are more exposed to air pollution than walking adults. As infants are more vulnerable and UFP have more effects on their health, measures should be taken to protect this population when it is transported in the street.
Shielding device, shielding process and crosslapper

A crosslapper, a process and a formed fabric web shielding device for a cross lapper shield a formed fabric web moved in the crosslapper. The formed fabric web has a bottom side, a top side and side surfaces located at formed fabric longitudinal edges. The crosslapper includes a displaceable main carriage and a crosslapper laying belt feeding the formed fabric web in a web direction to the displaceable main carriage with the formed fabric web bottom side located on the cross lapper laying belt. The shielding device includes a housing configured to be arranged in the crosslapper and configured to cover the side surfaces of the formed fabric web located on the laying belt and being fed to the displaceable main carriage, which side surfaces extend along the web direction, to shield the side surfaces of the formed fabric web against external environmental effects.
Holistic networking of creative industries via hubs

Greece and Italy have huge cultural and natural assets that can contribute to boost their economic growth and improve people’s quality of life.
 
The main objective of Creative@Hubs project is to establish an increased synergy between creative industries and Public authorities in order to contribute the capability of regions to create new knowledge and to generate innovation. The creative industries – which include advertising, marketing, architecture, arts and crafts, design, fashion, film, video, photography, music, performing arts, publishing, research & development, software, computer games, electronic publishing, and TV/radio – are the lifeblood of the creative economy, because their core business is the "ability to create", for the production of new ideas, concepts, plans, links, processes and clusters.

The project aims to support the integration of creative issues at governance level, to help creative entrepreneurs and resources in the field of innovative industries, by promoting innovation through existing local systems (clusters, laboratories, universities, science parks).

Thanks to this project, 6 buildings will be renovated in Creative Hubs: 4 Hubs in Greece, in the town of Agrinio, in the neoclassical building in Messolonghi in the Agricultural School of Patras and in Pyrgos, while in Italy the pavillon 115 of Fiera del Levante and a Pavillon of Foggia Fair will be renovated. 
Lead partner is the Region of Western Greece, in cooperation with Region of Epirus, Region of Ionian Islands and Puglia Region - Department of Agriculture, Rural Development and Environmental Protection.
A proposal for a drug product Manufacturing Classification System (MCS) for oral solid dosage forms

This paper proposes the development of a drug product Manufacturing Classification System (MCS) based on processing route. It summarizes conclusions from a dedicated APS conference and subsequent discussion within APS focus groups and the MCS working party. The MCS is intended as a tool for pharmaceutical scientists to rank the feasibility of different processing routes for the manufacture of oral solid dosage forms, based on selected properties of the API and the needs of the formulation. It has many applications in pharmaceutical development, in particular, it will provide a common understanding of risk by defining what the "right particles" are, enable the selection of the best process, and aid subsequent transfer to manufacturing. The ultimate aim is one of prediction of product developability and processability based upon previous experience. This paper is intended to stimulate contribution from a broad range of stakeholders to develop the MCS concept further and apply it to practice. In particular, opinions are sought on what API properties are important when selecting or modifying materials to enable an efficient and robust pharmaceutical manufacturing process. Feedback can be given by replying to our dedicated e-mail address (mcs@apsgb.org); completing the survey on our LinkedIn site; or by attending one of our planned conference roundtable sessions.
Development of RFID dressing robot using DC servo motor with fuzzy-PID control system

This paper presents a combination of RFID and robotic technologies for developing a cloth-dressing robot system in the field of robot's body clothing innovation. By using the RFID as key elements for data management to command an adaptive cloth-dressing robot control with fuzzy-PID controller to create value add of dressing room services management system and also changes the customer's life styles especially in the body size clothing in the future. This RFID technique deals with multiusers and an adaptive cloth-dressing robot that can be provide an efficiency time management scheme with correctly data report of each user and can work out in the real time. In particular this paper also studies the problems of detection tracking of the RFID tag that is relatively with the data base and the cloth-dressing robot module platform correctly. This RFID tag is equipped by user via Wi-Fi connected between user and cloth-dressing data based server. The necessary data for the robot system to operate include dimensions of the user's shoulder, chest, waist, and body height. Based on details of the user's body size were given by RFID devices, the robot can adjust its size and shape allowing testing of dressing clothes to be performed. The robot module is controlled by fuzzy-PID controller for resizing the robot's body size that relatively with the user's body size data. The fuzzy-PID controllers can be used to solve this objective because of the main advantage of fuzzy logic is that no mathematical modeling of any cloth-dressing body is required but can be achieved higher performance with effective tuning initial setting parameters. Finally, experimental results are revealed that the data based software can work well and fuzzy-PID can perform high performance control but must be improved for more accuracy and practical to use the robot mechanism such in the real situation of any cloth-dressing room environmental.
Cooled scientific instrument assembly onboard SPICA

ABSTRACT The Space Infrared Telescope for Cosmology and Astrophysi cs (SPICA) is a 3.2m cooled (below 6K) telescope mission which covers mid- and far-IR waveband with unprecedented sensitivity. An overview of recent design updates of the Scientific Instrument Assembly (SIA), composed of the telescope assembly and the instrument optical bench equipped with Focal Plane Instruments (FPIs) are presented. The FPI international science and engineering review is on-going to determine the FPI suite onboard SPICA: at present the mandatory instruments and functions to perform the unique science objectives of the SPICA mission are now consolidated. The final decision on the composition of the FPI suite is expected in early 2013. Through the activities in the current pre-project phase, several key technical issues which impact directly on the instruments performances and the science requirements and the observing efficiency have been identified, and extensive works are underway both at instrument and spacecraft level to reso lve these issues and to enable the confirmation of the SPICA FPI suite. Keywords: SPICA, space telescope, Joule-T homson cooler , infrared astronomy
Image processing device, image forming apparatus, image processing method, and non-transitory computer-readable storage medium

An image processing device includes: an image classifying section which, through a convolutional neural network, classifies each pixel of input image data as expressing or not expressing a handwritten image to calculate a classification probability of each pixel, the classification probability being a probability that the handwritten image is expressed; a threshold setting section which sets a first threshold when removal processing to remove the handwritten image is performed and a second threshold which is smaller than the first threshold when emphasis processing to emphasize the handwritten image is performed; and an image processor which adjusts a gradation value of pixels with a classification probability no smaller than the first threshold to remove the handwritten image when the removal processing is performed and adjusts the gradation value of pixels with a classification probability no smaller than the second threshold to emphasize the handwritten image when the emphasis processing is performed.
Les sciences participatives au service du patrimoine côtier menacé par les changements globaux dans les îles françaises de la Caraïbe : la démarche du projet ALOA

La montée du niveau marin et la multiplication des épisodes extrêmes (fortes tempêtes, cyclones) induits par le changement climatique global, conjugués à une pression anthropique accrue sur les rivages, sont autant de phénomènes qui affectent de façon grandissante les zones côtières. Sur le littoral caribéen, des centaines de sites archéologiques sont aujourd’hui menacés par une destruction plus ou moins rapide. Dans ce contexte, le projet « Archéologie Littorale Outre-Atlantique » (ALOA), pour l’heure initié en Guadeloupe, contribue à renforcer l’action des services de l’État dans les domaines de la connaissance et de la préservation du patrimoine archéologique côtier des Petites Antilles. Le projet ALOA vise ainsi à développer diverses actions de sciences participatives par l’activation d’un réseau d’observateurs utilisant un outil interactif en ligne spécifiquement créé à cet effet. Il permet de signaler les sites archéologiques littoraux nouvellement exposés. Le dispositif ALOA propose alors des préconisations à l’attention des services de l’État et des gestionnaires du territoire, concernant l’intérêt scientifique des sites menacés, leur degré de vulnérabilité, et les mesures de prévention ou d’intervention prioritaires pouvant être envisagées.
Innovative quality of experience management in emerging multimedia services

The realization of the paradigm of Internet anywhere, anytime and any-device and the diffusion of end-user multimedia devices with powerful and user-friendly capabilities such as smartphones, tablets PCs, mobile gaming terminals and e-books, are leading to the proliferation of a significant amount of emerging multimedia services: immersive environments, mobile online gaming, 3D virtual world, book/newspaper consumption, social networking, IPTV applications, just to cite a few. Some of these services have already reached a major market success, such as the case of newspaper/magazine mobile readers and smartphone multimedia apps. Their success has been achieved especially because a user-centered approach has been followed to design the whole process of content production, service activation, content consumption, service management and updating. From these considerations it arises that management of the Quality of Experience (QoE) is undoubtedly a crucial concept in the deployment of future successful services and it is straightforward to be understood but complex to be implemented in real systems, since there are many variables which will affect QoE, and these variables are changeable and span multidisciplinary areas including multimedia signal processing, communications, computer networking, psychology and sociology. 
This Network focuses on the analysis, design, optimization and management of the QoE  in advanced multimedia services, creating a fully-integrated and multi-disciplinary network of 12 ESRs working in and seconded by 7 academic institutions, 3 private companies and 1 standardization institute distributed in 6 European countries and in Korea. This Network will offer to a group of newly recruited Fellows in a cross-sectoral environment to shape their long-term research view and get fundamental methodological tools on various research fields, namely: multimedia networking, signal processing, communications,  business,  psychology and sociology.
An Oscillation Criterion for First Order Difference Equations

This paper is concerned with the oscillatory behavior of first order difference equation with general argument

 $$\Delta x(n) + p(n)x\left( \tau (n)\right) = 0,\quad n = 0,1,\ldots \qquad\qquad (\star)$$
 where $${{(p(n))_{n\geq 0}}}$$
 is a sequence of nonnegative real numbers and $${{(\tau (n))_{n\geq 0}}}$$
 is a sequence of integers. Let the numbers k and L be defined by

 $$k = \liminf\limits_{n \rightarrow \infty} \sum \limits_{j=\tau (n)}^{n-1}p(j)$$
 and

 $$L=\limsup\limits_{n\rightarrow \infty} \sum\limits_{j=\tau(n)}^{n}p(j).$$
 It is proved that, when L < 1 and $${{0 < k \leq \frac{1}{e},}}$$
 all solutions of Equation (
 $${{\star}}$$
 ) oscillate if the condition

 $$L > 2k+\frac{2}{{\rm \lambda} _{1}}-1$$
 where $${{{\rm \lambda} _{1}\in \lbrack 1,e]}}$$
 is the unique root of the equation $${{{\rm \lambda} =e^{k\lambda },}}$$
 is satisfied.
PKDE4J: Entity and relation extraction for public knowledge discovery

• The study presents PKDE4J, an extensible and flexible text mining system. • The system consists of two modules, entity extraction and relation extraction. • The performance achieves 85% for entity extraction and 81% for relation extraction. • PKDE4J can be a middleware for applications like building a knowledge graph. Due to an enormous number of scientific publications that cannot be handled manually, there is a rising interest in text-mining techniques for automated information extraction, especially in the biomedical field. Such techniques provide effective means of information search, knowledge discovery, and hypothesis generation. Most previous studies have primarily focused on the design and performance improvement of either named entity recognition or relation extraction. In this paper, we present PKDE4J, a comprehensive text-mining system that integrates dictionary-based entity extraction and rule-based relation extraction in a highly flexible and extensible framework. Starting with the Stanford CoreNLP, we developed the system to cope with multiple types of entities and relations. The system also has fairly good performance in terms of accuracy as well as the ability to configure text-processing components. We demonstrate its competitive performance by evaluating it on many corpora and found that it surpasses existing systems with average F -measures of 85% for entity extraction and 81% for relation extraction.
Utilizing innovation potential of urban ecosystems

URBAN INNO is addressing the challenge to make CE more innovative and competitive by maximising the innovation potential of smaller and medium sized urban ecosystems.
A significantly better linkage of actors within urban innovation ecosystems (public authorities, research organizations, industry as well as end-users respectively customers and citizens) is needed for a better use of innovation potentials. Public and private sectors recognize that there is especially a significant gap in the field of participation in innovation processes from people as citizens and as users/customers. Many smart solutions, technologies and services are not used widely because of the lack of knowledge and motivation or acceptance of end-users.
URBAN INNO focuses on maximising innovation potentials of urban ecosystems through: a) better linkage of actors in innovation systems by establishing and interlinking quadruple helix clusters/networks in the partner regions, and b) by the development and implementation of new participatory methods and tools to engage end-users in innovation processes with the objective to have educated and motivated users – SMART USERS.
URBAN INNO will be implemented in small-medium sized urban ecosystems in CE with strong replication potential due to the big number of similar-sized cities in EU.
Quadruple-helix networks will be established and regional/urban innovation action plans developed (setup of demo centres and testbeds for industry). In parallel, new participatory methods and tools will be developed and tested in pilot projects. Participative urban environments will substantially improve their innovation performance with the established innovation environment.
A transnational cooperation strategy and platform will provide all interested regions the best available participatory tools and qualified facilitators and best practice will enable transfer and exchange of urban innovation models and practices throughout CE.
Research on Big Data Reference Architecture Model

For ISO / / IEC TS 25011:2017 some deficiencies of big data reference system. In this paper, we redesigned the big data reference system structure model, and proposed a goal (big data information service quality), three chains (information value chain, information technology value chain and information assurance value chain) and five roles (big data application provider, big data framework provider and big data information assurance provider) 1-3-5 model of data provider and data consumer, and all the attributes of the model are described. In the part of big data information service quality, the deficiencies in ISO / / IEC TS 25011:2017 are corrected. Then, the basic system of big data is proposed. Under the big data reference architecture model proposed in this paper, compared with some other typical models, the conclusion is that other typical models can be replaced completely.
An evaluation of the robustness of global amphibian range maps

Aim

Maps of species ranges are among the most frequently used distribution data in biodiversity studies. As with any biological data, range maps have some level of measurement error, but this error is rarely quantified. We assessed the error associated with amphibian range maps by comparing them with point locality data.



Location

Global.



Methods

The maps published by the Global Amphibian Assessment were assessed against two data sets of species point localities: the Global Biodiversity Information Facility (GBIF), and a refined data set including recently published, high-quality presence data from both GBIF and other sources. Range fit was measured as the proportion of presence records falling within the range polygon(s) for each species.



Results

Using the high-quality point data provided better fit measures than using the raw GBIF data. Range fit was highly variable among continents, being highest for North American and European species (a fit of 84–94%), and lowest for Asian and South American species (a fit of 57–64%). At the global scale, 95% of amphibian point records were inside the ranges published in maps, or within 31 km of the range edge. However, differences among continents were striking, and more points were found far from range edges for South American and Asian species.



Main conclusions

The Global Amphibian Assessment range maps represent the known distribution of most amphibians well; this study provides measures of accuracy that can be useful for future research using amphibian maps as baseline data. Nevertheless, there is a need for greater investment in the continuous updating and improvement of maps, particularly in the megadiverse areas of tropical Asia and South America.