SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Exposing nature’s view of ligand recognition in ionotropic glutamate receptors

Molecular biology strives for the prediction of function, based on the genetic code. Within neuroscience, this is reflected in the intense study of the molecular basis for ligand recognition by neurotransmitter receptors. Consequently, structural and functional studies have rendered a profoundly high-resolution view of ionotropic glutamate receptors (iGluRs), the archetypal excitatory receptor in the brain. But even this view is obsolete: we don’t know why some receptors recognize glutamate yet others recognize other ligands; and we have been unable to functionally test the underlying chemical interactions. In other words, our view differs substantially from nature’s own view of ligand recognition. I plan to lead a workgroup attacking this problem on three fronts. First, bioinformatic identification and electrophysiological characterization of a broad and representative sample of iGluRs from across the spectrum of life will unveil the diversity of ligand recognition in iGluRs. Second, phylogenetic analyses combined with functional experiments will reveal the molecular changes that nature employed in arriving at existing means of ligand recognition in iGluRs. Finally, chemical-scale mutagenesis will be employed to overcome previous technical limitations and dissect the precise chemical interactions that determine the specific recognition of certain ligands. With my experience in combining phylogenetics and functional experiments and in the use of chemical-scale mutagenesis, the objectives are within reach. Together, they form a unique approach that will expose nature’s own view of ligand recognition in iGluRs, revealing the molecular blueprint for protein function in the nervous system.
Improvements in and relating to priming and regulating devices for pumps of the screw, centrifugal and valveless type

219,844. Seaborne, A. B. Oct. 23, 1923. Starting, facilitating; controlling.-A priming device for centrifugal and valveless pumps keeps water flowing through the pumps and only passes air in small controlled quantities. A tank a is connected above the pump c and between the pump inlet b and suction pipe d. Within the tank is an ejector device e of the type described in Specifications 202,595 and 206,878, and a float f controlling the valve g in the pipe h communicating between the reservoir i and the suction pipe d at the point where it enters the tank a. In normal operation all liquid passes through the tank a before entering the pump. If there is a break in the supply, the float f falls and opens the valve g. Liquid enters the tank a from the reservoir i and passes through the pump with entrained air from the suction pipe d until the break in supply is remedied and the float f rises to close the valve g. The reservoir i may have an independent supply or may be supplied from the pump discharge pipe k.
ANCLA MARINA MEJORADA.

UN ANCLA MARINA (1) TIENE UNA UÑA (2) CON UNA CAÑA (3) UNIDA A LA UÑA QUE COMPRENDE UN PUNTO DE FIJACION DE LINEA DE ANCLA (10). UN CONJUNTO DE PLACA TRASERA (4) DEBAJO DE LA UÑA (2) ESTA INCLINADA EN ANGULO OBTUSO (ALFA) HACIA LA UÑA (2) Y SIRVE PARA PREVER UN MOMENTO DE GIRO ALREDEDOR DEL PUNTO DE FIJACION (109 QUE SE OPONE A LOS MOMENTOS DE GIRO PRODUCIDOS POR EFECTO DE FRICCION SOBRE LA UÑA Y LA CAÑA Y POR RESISTENCIA DE BORDES DURANTE EL ENTIERRO DEL ANCLA PARA PROPORCIONAR UNA POTENCIA DE SUJECION MEJORADA AL ANCLA MIENTRAS EL SUELO SE ABRE PASO (5) ENTRE EL CONJUNTO TRASERO (4) Y LA UÑA (2) PERMITE EL ESCAPE DE ARENA Y FANGO BLANDO QUE PASA SOBRE LA UÑA. LOS BORDES PERIFERICOS (4A) DEL CONJUNTO TRASERO (4) ESTAN PERFILADOS PARA HACER QUE EL ANCLA RUEDA HACIA UNA POSICION DE ENTIERRO. UNA PARTE DE PUNTA GIRADA HACIA ARRIBA (9) EN LA PARTE FRONTAL DE LA UÑA FORTALECE LA OPERACION EFECTIVA DEL ANCLA EN SUELOS DE ARCILLA MIENTRAS QUE TAMBIEN FACILITA EL AGARRE EN ROCA DEL ANCLA.
Scientific Production on Cultural Exchange: an analysis of the literature

El intercambio cultural es un tipo de producto conocido en el mercado turístico, sin embargo, existe una gran variación en las prácticas, así como en las formas en que el sujeto es tratado como objeto de estudio, asumiendo diversas nomenclaturas y significados polisémicos. En ese sentido, este trabajo está dedicado a comprender cómo se aborda el tema en la producción científica internacional, a través de una investigación bibliográfica a partir de un listado de términos que hacen referencia al tema bajo diversos enfoques: Intercultural exchange, Cultural exchange, Study abroad, Work and Travel, Academic mobility, Exchange tourism, Youth tourism. Se buscaron producciones científicas hasta mayo de 2021 que trajeran como parte del título alguno de estos términos asociados al turismo (presentes en las palabras clave de los trabajos). Para el análisis y visualización de los resultados se utilizaron las aplicaciones VOSViewer y el sitio web Wordclouds. Los resultados mostraron que, en el ámbito científico, los términos que más se han producido son Study Abroad, Cultural Exchange, y Academic Mobility, con cierta preponderancia de los temas educativos y de formación profesional, de forma independiente. Los resultados también mostraron que la producción científica en este campo de estudio comenzó a crecer exponencialmente a partir de la década de 2000, siendo Estados Unidos el principal país productor de publicaciones.
Magnetic Titanium Dioxide Nanocomposites for Surface-Enhanced Resonance Raman Spectroscopic Determination and Degradation of Toxic Anilines and Phenols

Mesoporous M-TiO2 NCs, functionalized by PATP, can capture toxic anilines and phenols by azo coupling. Loading these nanodevices with Ag NPs offers the possibility for a sensitive quantitative determination of target compounds by SERRS spectroscopy, which allows multiplex detection because of the specific vibrational fingerprints. Sensitivity and selectivity can be further enhanced by concentrating the hybrid particles by an external magnet and compound-specific binding (anilines versus phenols). The bound toxic compounds can be degraded by TiO2-assisted photocatalysis after removal of the loaded hybrid particles from the sample solution with an external magnet. The degradation process can be enhanced in the presence of plasmonic Ag nanostructures.
Macrocyclic receptors for selective anion extraction

Developing selective receptor molecules for biologically relevant anions will enable major technological advances for rapid sensing, and extraction and removal of toxic components from waste waters. However, selective binding in water with synthetic receptors is difficult to achieve since water effectively competes with receptor-anion interactions. MAREXT aims to offer pioneering solutions for the selective binding of targeted anions in water by novel calixpyrrole assemblies: micelles with hydrophilic polyethylene glycol tails for the selective recognition of anti-inflammatory drugs with carboxylate groups. The project focuses on advanced synthesis of the calixpyrrole receptors, preparation and characterization of the micellar assemblies, and extraction of target anions from water. MAREXT combines the expertise of the experienced researcher and Prof. Ballester’s group promoting multidisciplinarity and knowledge transfer in fields of colloids and molecular recognition. The fellowship provides training for the candidate in advanced synthesis, chromatography and DOSY NMR, and transferable skills such as research project management, grant writing and scientific communication. The results of the high-impact project will improve the capacity of the candidate to achieve her next career stage and improve the competitiveness of Europe in extraction technologies.
Histological Characteristics of Adult Yak Epididymis in Different Breeding Seasons

To compare the histological changes of the adult yak’s epididymis in different breeding seasons,six adult yak testis in breeding season and nine adult yak testis in breeding interval were collected for structure investigation by HE staining,Masson’s and Gomori ’s histochemistry methods,and IPP (Image-Pro Plus)statistics method was used to quantitative statistics.The re-sults showed that comparing with the adult yak in the breeding interval,the epididymis ducts of adult yak in the breeding season were covered with the columnar ciliated epithelium.The collagen and reticular fiber in cauda epididymis were obviously more abundant than caput and corpus epi-didymitis.And the thickness of columnar epithelium cells in caput and corpus epididymitis,the length of the cilia in caput,and also the internal and external lumen diameter of caput and corpus epididymitis were all significantly increased in the breeding season (P 0.05).In conclusion, the research showed that the distribution of collagen and reticular fiber in adult yak’s epididymis interstitial were similar,and they were more rich in cauda epididymis,which might relate to the capacity and the sperm transport;The changes of the epithelial thickness,the length of cilia,the internal and external lumen diameter were close related to the different breeding seasons,and it might be a common phenomenon in plateau mammals that the enlargement and reduction of the epididymal duct in different breeding seasons.
Enhancing the Environmental Impact Assessment for the Foreign Direct Investment Regime in Vietnam: an Analysis from Integration Perspective

Foreign direct investment (FDI) plays an important role in the economic growth of Vietnam, contributing to nearly 22 per cent of the GDP. To attract FDI the government has committed to promoting investment climate and ensuring FDI protection under various international arrangements. FDI inflows into the manufacturing and processing sectors have seen a strong increase after Vietnam’s successful accession to the WTO. However, FDI also contributes to various environmental problems and challenges in Vietnam. From 2008 to 2017, most serious environmental disputes related to manufacturing activities were caused by FDI enterprises. The sanctions against FDI enterprises, however, may jeopardise the state’s responsibilities under investment protection treaties. One of the few realistic approaches to strengthening the environmental management of FDI is to promote the participation of the public in the environmental risk assessment and amend the investment treaties to regulate the issue of environment management. This study will adopt an integrative approach by integrating the rules and principles of environmental management into the FDI regime of Vietnam.
The Impact of Advertising on the Profitability of Public &Private Sector Commercial Banks

The purpose of this study is to investigate the impact of advertising on the profitability of commercial banks over the period of 2008- 2012, in the presence of control variables: Credit risk, Operating Efficiency, total advances to total deposits, total loans to total assets and Size(total assets) ratio. Bank’s profitability is measured in terms of return on equity (ROE) .The data has been obtained from the publications of  State Bank of Pakistan (SBP) and commercial banks. The regression results confirm the positive and significant effects of advertising expenditure on ROE for private sector banks than public sector banks. Keywords: ROE, ROA, Advertising, Credit Risk, Operating Efficiency, Bank Deposits & Advances JEL- Classification :  G-21
Uncaging Calcium in Neurons

Changes in intracellular free calcium concentration (Δ[Ca 2+ ] i ) driving physiological events such as neurotransmitter release or Ca 2+ -dependent currents can be monitored using Ca 2+ -sensitive fluorescent dyes. Although these dyes can correlate Δ[Ca 2+ ] i with a physiological event, they cannot directly test for causality between changes in [Ca 2+ ] i and that event. Photolabile Ca 2+ chelators are Ca 2+ -binding molecules that can alter and, to a certain extent, control [Ca 2+ ] i in an inducible manner and with temporal and spatial resolution that surpasses microinjection or ionophore application. Here we discuss the properties of caged Ca 2+ compounds as well as some practical considerations for their use in neuronal cells, where they have proven particularly effective.
Siade saas: spatial decision support system for transportation planning

The demand for passenger transport will grow 51% by 2050, triggering a market growth to €100.6 billion by 2019. Smart Mobility enabled by Smart Public transport is key for cities’ economy and development. Worldwide transport operators are implementing AFCs (Automated Fare Collection) for a better urban transportation experience, generating Big Data, but lacking passenger destination information. However, turning these data into knowledge is challenged by the difficulty to accurately describe transport network states and computational burden coming from processing Big Spatial Data to derive metrics of capacity utilization, punctuality, passenger volumes at stops, or travel patterns of different user groups. SIADE SaaS is a spatial decision support system for bus transportation planning and other transportation systems where user destination is unknown. It delivers the most complete and accurate OD matrix in the transport industry using GIS and AFCs data. Our current SW has already attracted the attention of several Transport Operators in 7 countries. We are making a strategic transition from offering consultancy services to software product commercialization on global scale, using a user driven improvement of SIADE based on an incremental methodology. The evaluation of the transportation network and the potential information provided by SIADE SaaS is multidimensional: social equity, service quality, network structure and environmental impact. It helps transit agencies plan per the actual demand, enabling economic and sustainable operations, while providing the population a service more adapted to its needs. For Terrain Technologies, innovation is a key point for growth. The company devotes an average of at least 50% of its resources to RD activities in an annual basis Our consolidated business plan predicts: up to 78 licenses will be sold in the period 2019-2023, resulting in accumulated revenues of over €7.8 million while also creating 25 new positions.
On the Assessment of Anhui Forestry Input-output Ratio Based on the Super-ratio Model DEA

In order to promote the construction of ecological forestry,Anhui Province has sharply increased its input on forestry from the year 1998.This article has assessed and analyzed its forestry input-output ratio with the assessment model DEA.The result suggests that the ratio is generally high from the year 1998 to 2002,but from the year 2003,the number of invalid years in the view of DEA has obviously increased,most of which the scale outputs are decreasing by degrees.In the background of the practical forestry development,it can be found that the reasons for such a low ratio are the unsteady input,the improper input output-structure and the sufficient technological input.
Monetary Policies,Asset Collateralability,Cash Flow and Corporate Investment:Evidence from Chinese Listed Company of Manufacturing Industry

By using quarterly data of the Chinese manufacturing listed companies from 2003 to 2011,following the calculation method of Berger et al.(1996) and AlmeidaCampello(2007) to estimate firm-specific asset collateralability and considering the monetary policy,the paper investigates the between the asset collateralability and cash flow on corporate investment from the combination of different investment opportunities and cash flow.It can be found that:(1) there is a substitution relationship between asset collateralability and cash flow on corporate investment when the corporations face high investment opportunities and plentiful cash flow,While,there is a complementary relationship between asset collateralability and cash flow on corporate investment when the corporations face high investment opportunities but insufficient cash flow;(2) tightening of ? monetary policy can improve the complementary relationship between asset collateralability and cash flow on corporate investment when corporations face high investment opportunities but insufficient cash flow.Our results are conducive to profound understanding of monetary policy and asset collateralability on investment and financing activities of micro enterprise,and make macro economic policy more scientific and reasonable, in order to improve the effect of macroscopic readjustment and control policies,and promote China's macro economic stable growth.
Reconstruction using ‘triangular approximation’ of bone grafts for orbital blowout fractures

There are many orbital wall reconstruction materials that can be used in surgery for orbital blowout fractures. We consider autogenous bone grafts to have the best overall characteristics among these materials and use thinned, inner cortical tables of the ilium. A bone bender is normally used to shape the inner iliac table to match the orbital shape. Since orbital walls curve three-dimensionally, processing of bone grafts is not easy and often requires much time and effort. We applied a triangular approximation method to the processing of bone grafts. Triangular approximation is a concept used in computer graphics for polygon processing. In this method, the shape of an object is represented as combinations of polygons, mainly triangles. In this study, the inner iliac table was used as a bone graft, and cuts or scores were made to create triangular sections. These triangular sections were designed three-dimensionally so that the shape of the resulting graft approximated to the three-dimensional orbital shape. This method was used in 12 patients with orbital blowout fractures, which included orbital floor fractures, medial wall fractures, and combined inferior and medial wall fractures. In all patients, bone grafts conformed to the orbital shape and good results were obtained. This simple method uses a reasonable and easy-to-understand approach and is useful in the treatment of bone defects in orbital blowout fractures when using a hard graft material.
In vitro and ex vivo evaluation of an intestinal permeation enhancing self-microemulsifying drug delivery system (SMEDDS)

The objective of this study was to develop a self-microemulsifying drug delivery system (SMEDDS) that enhances drug absorption through intestinal membranes and to evaluate the mechanism of improvement. The developed formulation was optimized in order to reduce the droplet size and characterized in several environments. Furthermore, a pseudo-ternary phase diagram was mapped in order to identify the o/w microemulsion region. The formulation contains 30 % (m/m) Cremophor EL, 30 % (m/m) Capmul MCM, 10 % (m/m) propylene glycol and 30 % (m/m) Captex 355. Permeation studies were carried out in vitro on Caco-2 cell monolayers and ex vivo on rat intestine in Ussing-type chambers using model compounds rhodamine-123 (Rho-123) and fluorescein isothiocyanate-dextran 4 (FD4). The selected formulation improved in a concentration of 0.5 % (m/v) absorption of FD4 1.85-fold in vitro and 1.65-fold ex vivo via tight junction opening. Furthermore, the system had the ability to inhibit P-glycoprotein and improved the permeation of Rho-123 1.49 fold in vitro and 1.64 fold ex vivo. Stability studies were carried out to assure that the SMEDDS was stable during transport studies and in several media and buffers. According to these results, the developed formulation showed great promise in terms of improving the bioavailability of low-permeability drugs—often the rate-limiting step for oral drug delivery systems.
Electrical apparatus and electrical apparatus system

An electrical apparatus includes a circuit structure, a case provided with a bottom panel and a case peripheral wall, and a cover provided with a cover panel and a cover peripheral wall. At least a part of an inner surface of the cover peripheral wall and an outer surface of the case peripheral wall face one another, thereby forming a housing space and housing the circuit structure within the housing space. A groove is formed in at least one of (i) the entire periphery of the outer surface of the case peripheral wall or (ii) the entire periphery of the inner surface of the cover peripheral wall. This configuration provides a structure that suppresses infiltration of liquid to the inside of the case, and suppresses adhesion of liquid to the circuit structure.
Reply on RC1

<strong class="journal-contentHeaderColor">Abstract.</strong> This paper aims to analyze the risk of municipal urban water shortage in the state of Rio Grande do Norte (RN) through the results of the Index of Water Shortage Risk (IRDH). The theoretical-methodological assumptions are based on Walle and Birkmann (2015); Almeida, Welle and Birkman (2016); Medeiros (2018); Oliveira (2018); Macedo et al. (2020 e 2021). In this context, the IRDH was structured in a systemic perspective, where the territories of water shortage risk were identified through environmental, social and economic, and state planning indicators, using 19 variables as instruments of analysis. The research was conducted qualitatively and quantitatively, evaluating and analyzing the risk of water shortage in RN and the 153 cities that compose the system of supply managed by the Company of Waters and Sewers of Rio Grande do Norte (CAERN), a state concessionaire (representing 92 % of the 167 cities of the State), in its seven regions of water supply. The result of the IRDH of Rio Grande do Norte proved the relationship between the indicators in the water shortage problem in the State, classifying 49 % of the analyzed cities in the classes of &ldquo;high&rdquo; and &ldquo;very high&rdquo; risk, which places them in a situation of higher attention regarding the potential damages derived from the water shortage, 40.5 % of them being &ldquo;medium&rdquo; and 10 % &ldquo;low&rdquo; risks, with no occurrences of &ldquo;very low&rdquo; risk examples. In absolute values, 1 city was classified as &ldquo;very high&rdquo;; 74 were classified as &ldquo;high&rdquo;; 62 as &ldquo;medium&rdquo;; and 16 were considered of &ldquo;low&rdquo; risk of water shortage. With the goal of reducing/mitigating the results of the IRDH in the State, a transposition of watersheds, integration of supply systems, hydrogeologic research, among others, were proposed.