SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
IL-1β-Induced Mesenchymal Stem Cell Migration Involves MLCK Activation via PKC Signaling

Mesenchymal stem cells (MSCs) migrate via the bloodstream to sites of injury, possibly attracted by inflammatory cytokines. Although many cytokines can induce stem cell migration, the underlying mechanism is not fully understood. We found that tail vein-injected MSCs migrate to the pancreas in nonobese diabetic (NOD) mice. An ELISA assay revealed that hyperglycemic NOD mice have higher pancreatic levels of interleukin-1β (IL-1β) than normal NOD mice and that IL-1β stimulates MSC migration in a Transwell assay and electric cell–substrate impedance sensing system. Microarray analysis showed that myosin light chain kinase (MLCK) is involved in IL-1β-induced MSC migration, while Western blots showed that IL-1β stimulates MLCK expression and activation and that MLCK-siRNA transfection reduces MSC migration. Kinase inhibitors, chromatin immunoprecipitation, and a knockdown study revealed that IL-1β-induced MLCK expression is regulated by the PKCd/NF-κB signaling pathway, and a kinase inhibitor study revealed that IL-1β-induced MLCK activation occurs via the PKCa/MEK/ERK signaling pathway. These results show that IL-1β released from the pancreas of hyperglycemic NOD mice induces MSC migration and that this is dependent on MLCK expression via the PKCd/NF-κB pathway and on MLCK activation via the PKCa/MEK/ERK signaling cascade. This study increases our understanding of the mechanisms by which MSCs home to injury sites.
METHOD FOR MANUFACTURING WIND TURBINE TOWER STRUCTURE WITH EMBEDDED REINFORCEMENT ELEMENTS

A system for manufacturing a structure includes a supporting frame assembly (104) moveable in a vertical direction of the structure. Further, the system includes an additive printing assembly (118) secured to the supporting frame assembly. The additive printing assembly includes at least one printer head (120,122,130) configured to dispense a first cementitious material. The system also includes a reinforcement dispensing assembly (136) supported by the supporting frame assembly. Thus, the reinforcement dispensing assembly is configured to automatically and continuously dispense a plurality of reinforcing members as the structure is printed and built up via the at least one printer head and as the supporting frame assembly moves in the vertical direction.
How do Twitter, Wikipedia, and Harrison's principles of medicine describe heart attacks?

Social media, such as Wikipedia and Twitter, are an increasingly common source of medical information, including for medical students. It is unknown how medical information in social media compares to medical information in medical textbooks. Here we compare Wikipedia articles on heart attacks and palpitations and tweets mentioning heart attacks and palpitations to chapters from Harrison's Principles of Internal Medicine and Braunwald's Heart Disease on myocardial infarction and cardiac dysrhythmias. For heart attacks, the chapters from Harrison's had higher Jaccard similarity to Wikipedia than Braunwald's or Twitter. For palpitations, no pair of sources had a higher Jaccard (token) similarity than any other pair. For no source was the Jaccard (token) similarity attributable to semantic similarity. This suggests that technical and popular sources of medical information focus on different aspects of medicine, rather than one describing a simplified version of the other. We hope our work motivates further investigation into the representation of medical knowledge in different media.
Mast cell transcriptome elucidation: what are the implications for allergic disease in the clinic and where do we go next?

Mast cells (MCs) are principal effector cells of type-I-allergic reactions but still poorly defined in humans. The consortium Functional Annotation of the Mammalian Genome 5 has created a map of body-wide transcriptome data for a multitude of human cell types, including MCs. MCs were found to have a surprising transcriptional landscape expressing a range of genes not (or barely active) elsewhere in the body. Whereas several MC specific genes have no annotated function, others belong to networks defining specific MC traits and functions, such as granule architecture, IgER signaling, exocytosis and mediator production. Several of these genes are so highly enriched in MCs (versus all other cells), that they appear potentially specific targets for therapeutic interventions in diseases in which MCs are actively involved. We present some interesting candidates, highlight the uniqueness of MCs and discuss their role in allergy and itch sensation based on these renewed insights.
Optimization of operating parameters for efficient photocatalytic inactivation of Escherichia coli based on a statistical design of experiments

In this work, the individual and interaction effects of three key operating parameters of the photocatalytic disinfection process were evaluated and optimized using response surface methodology (RSM) for the first time. The chosen operating parameters were: reaction temperature, initial pH of the reaction mixture and TiO2 P-25 photocatalyst loading. Escherichia coli concentration, after 90 minutes irradiation of UV-A light, was selected as the response. Twenty sets of photocatalytic disinfection experiments were conducted by adjusting operating parameters at five levels using the central composite design. Based on the experimental data, a semi-empirical expression was established and applied to predict the response. Analysis of variance revealed a strong correlation between predicted and experimental values of the response. The optimum values of the reaction temperature, initial pH of the reaction mixture and photocatalyst loading were found to be 40.3 °C, 5.9 g/L, and 1.0 g/L, respectively. Under the optimized conditions, E. coli concentration was observed to reduce from 107 to about 11 CFU/mL during the photocatalytic process. Moreover, all these results showed the great significance of the RSM in developing high performance processes for photocatalytic water disinfection.
FLEXIBLE FUEL GENERATOR AND METHODS OF USE THEREOF

A portable flexible fuel generator, having an engine, includes: a cylinder and a spark plug in the cylinder, a primary fuel tank fluidly connected to the cylinder, an air intake path fluidly connecting atmosphere to the cylinder, a start module including a starting fuel tank holder and a starting fuel line, where the starting fuel line is fluidly connected to the air intake path, a coolant path which provide a flow path for coolant to cool the cylinder, and a thermal controller along the coolant path. Furthermore, the engine has full cylinder cooling.
Canvassing conversations: obstinate issues in studies of elites and elite education

Studies of elites and elite education have largely not involved rigorous debate, either with regard to the conceptual resources deployed or methodologies adopted. Even the concepts elite and elite schools have not been problematized much. Further, there is a tendency for people to cite, rather than engage or dispute each other. So while the number of published studies increases and the field grows in size, and expands in focus, it is not necessarily growing through spirited dialog and critique. The first part of this paper considers the ways in which the methodological scope in the study of elites and elite education has been restrained and limited through the repetition of particular methodological frameworks and practices. Drawing on the work included in this special issue and other recent research, we then suggest some methodological possibilities for expanding this scope. In the second main part, we offer some provocations about the theoretical resources that are conventionally deployed. We argue that...
Insurance-Based Discrimination During Prenatal Care, Labor, and Delivery: Perceptions of Oregon Mothers

The purpose of this study was to improve understanding of who experiences insurance-based discrimination during prenatal care, labor, and delivery and how their health care may differ from that of other women. We pooled data from the 1998-1999, 2000, and 2001 Oregon Pregnancy Risk Assessment Monitoring System and conducted univariate, bivariate, and multivariate analyses. The women who perceived that they had been treated differently by health care providers during prenatal care, labor, or delivery based on their insurance status were largely a lower income group. Insurance-based discrimination was significantly associated with lower annual household incomes, being unable to pay bills during pregnancy, and being without employer-sponsored insurance for their baby's delivery, when adjusted for other factors. Insurance-based discrimination was less likely among Hispanic mothers. With respect to the relationship between insurance-based discrimination and receipt of health care, our findings were mixed. Insurance-based discrimination was not significantly associated with the number of topics covered by providers during prenatal care. In contrast, insurance-based discrimination was significantly associated with fewer breastfeeding support actions taken at the hospital and with having had a provider discuss birth control after delivery among women with employer sponsored insurance. These findings draw attention to the need to better understand women's experiences and perceptions of insurance-based discrimination during prenatal care, labor, and delivery.
Desarrollo de la capacidad de gestión y crecimiento sostenible de «Ultracom» Ltd.

«Ultracom» Ltd. es una empresa que ofrece servicios de alta calidad en el campo de la tecnología de la información, procesamiento de datos, hosting, etc. La cartera contiene una variedad de servicios que se ofrecen a más de 1000 clientes en el país y en el extranjero. Los requisitos del mercado para los servicios de software se incrementan considerablemente debido al entorno empresarial altamente competitivo y a la dinámica con la que se está desarrollando este sector. Se buscan soluciones modernas para optimizar los procesos y ampliar oportunidades para ofrecer a los clientes calidad, cantidad y seguridad de los bienes y servicios ofrecidos. «Ultracom» Ltd. maneja la rica nomenclatura, que requiere la contratación y gestión del personal; gestión de flujo de caja, marketing y publicidad, trato con clientes y proveedores, etc. Todo esto, en los volúmenes con los que se trabaja, a menudo conduce a un derrame de información, lo que resulta en decisiones de gestión inexactas, devoluciones de clientes, incapacidad para ejecutar determinados pedidos rápidamente, retrasos y coste total del flujo de trabajo debido a costes operativos adicionales, especialmente actividades de protección del medio ambiente. Esto expone a la empresa a la necesidad de construir un único sistema de software de base de datos común que abarque todos los procesos de negocio — planificación, presupuestación y control en el campo de la prestación de servicios, ventas, recursos, contabilidad, así como un sistema unificado para la normalización de la calidad de los servicios ofrecidos. Para satisfacer esta necesidad identificada, es necesario implementar un sistema integrado de gestión de procesos empresariales — 1 pcs., acompañado de un servidor — 1 pcs., 1 sistema de gestión ambiental ISO 14 001 y 1 sistema de gestión de la calidad ISO 9001, que cubrirá todos los procesos de negocio y ofrecerá una amplia gama de funcionalidades y conducirá a una organización interna de innovación altamente eficiente, mejores posiciones en el mercado, aumento de los ingresos de exportación.
Delivering services on behalf of h2020 for enhancing the innovation management capacity of smes by the enterprise  europe network in flanders

This proposal aims at continuing the services of EEN in Flanders with regard to the key account management for the SME instrument under the H2020 programme as entrusted by the European Commission to the Enterprise Europe network. It also concerns the additional support services that EEN will deliver in Flanders with regard to the enhancement of the innovation management capacities of SMEs as decided in the H2020 programme. The present proposal describes how the Flemish VEBIN consortium - being selected for delivering the EEN services in Flanders -will deliver the services concerned in their region in 2015 and 2016, how these will be coordinated with the H2020 NCP for SMES in Flanders, how the services will be embedded in the regional innovation support system to the benefit of Flemish companies, how the consortrium will manage the services and how feedback will be organised in order to ensure a high quality service provision and an added European value, while respecting the principles of additionality. It particularly reflects on the signposting of clients among all relevant support stakeholders and to the efficient use of resources and tools. It also confirms the consortium's willingness to cooperate whenever requested by EAME or the Commission to share best practices among the participating EEN consortia and to give feedback on the implementation of the services in the region of Flanders (Belgium).
Demonstration of a new diagnostic device for the overactive bladder syndrome

ALBYN MEDICAL has developed, in cooperation with the Chemnitz University of Technology and the University Hospital of Cologne (Germany), a specific diagnostic system for the Overactive Bladder syndrome. This diagnostic device is implanted by cystoscopy and measures the bladder pressure autonomously, relating the bladder pressure with the urination, controlled or not, and it determines if the pressure rise appears only when a voluntary urination occurs or if also occurs other times as in the accidental urine loss.
Thanks to the new diagnostic device a reliable diagnostic evaluation is obtained and thus high treatment costs of the current Overactive Bladder over-diagnosis are avoided improving the sustainability of the European Health and Care systems.
Esquentador de circulação de ar forçado paciente inteligente para uso com capas de uso único dedicados

SA 42799(2015/X) O tema do projeto é o desenvolvimento de um novo dispositivo, «esquentador inteligente de pacientes com circulação de ar forçada com coberturas de uso único dedicados», projetado para prevenir a hipotermia, mantendo a temperatura corporal adequada em um paciente exposto a resfriamento e/ou aquecimento do paciente resfriado. O dispositivo será especialmente dedicado à aplicação de áreas que, devido à especificidade, requerem o uso de coberturas para uso em apenas um paciente — ou seja, internações hospitalares, pronto-socorro hospitalar, anestesiologia e departamento de terapia intensiva, enfermarias infecciosas. Durante a criação da nova, será tida em conta a experiência do contratante recolhida durante o projeto «Sistema de Aquecimento de Doentes Inteligentes». Entre outras coisas, será implementada uma interface gráfica de utente, utilizando um ecrã tátil com um sistema de comunicação conversacional, o que representará uma inovação significativa em relação às soluções presentes no mercado. Um sistema avançado de segurança do trabalho será usado, incluindo o uso de múltiplos sensores de temperatura e funções de autodiagnóstico. O novo dispositivo atenderá aos crescentes requisitos relacionados ao cumprimento dos padrões epidemiológicos, através do uso de capas de uso único, do uso de filtros de ar de alta qualidade, da adaptação do dispositivo principal para desinfeção em condições hospitalares. O projeto terá em conta as necessidades dos utilizadores e dos atuais clientes do requerente. Entre outras coisas, o dispositivo será caracterizado por trabalho silencioso, permitirá monitorar a terapia individual do paciente e terá várias opções de montagem, incluindo a disponibilidade de um stand móvel. O envolvimento dos utilizadores finais no processo de criação de um novo produto consistirá em examinar as necessidades e, em seguida, em ensaios funcionais do protótipo do dispositivo e verificar o seu desempenho em relação aos requisitos e pressupostos definidos.
Foreign Direct Investment &amp;amp; Economic Growth in Sub-Saharan Africa: An Empirical Study

This study has made an attempt to investigate and analyze empirically the impact of Foreign Direct Investment (FDI) on the economic growth for a panel of 32 Sub-Saharan African countries during the period 2008-2014. Both static panel regression techniques and dynamic panel estimates were employed to assess the causal link of our regressors, namely, FDI, trade openness, domestic investment, working population size and the effects of the 2009 European debt crisis on our dependent variable, Gross Domestic Product (GDP) per capita. The evidence from the statistical analysis suggests that aggregated FDI does have a positive and significant impact on economic growth and is thus consistent with the literature, especially with respect to developing countries. Based on static random effects, the inclusion of the 2009 Euro zone crisis did not diverge the results despite its negative impact on economic growth. The contribution of FDI is observed to be relatively higher than domestic investment.
Royal ideology and legitimacy at the beginning of new kingdom: the function and decorative program of temples of millions of years

The iconography of temples is an aspect that has been frequently treated in Egyptian research. Yet, it is still an important source of knowledge for understanding the religion, thought, or ideology of ancient Egypt. In the 18th dynasty (ca. 1539-1292 BC), a time of ideological rebirth and political stability, specific constructions proliferate: the temples of millions of years. This action will conceive how the decoration of these temples possessed a particular iconographic program and how their iconographic programs may reflect the needs of the kingship and legitimacy, as well as to explore the relations of power and identity established at that period. For this purpose, the proposal will focus on a specific aspect: the analysis of the interactions between the royal and funerary worship of the sovereign in the temples of millions of years and in other types of temples dedicated to deities, as well as in relation to the royal and private tombs. A database will, for the first time, gather scenes related to the project. The action will be carried out in the section Égypte Nilotique et Méditerranéenne (ENiM) of the laboratory of Archéologie des Sociétés Méditerranéennes (ASM, UMR 5140, CNRS, University Paul-Valéry, Montpellier) under the supervision of Prof. Marc Gabolde and Prof. Sébastien Biston-Moulin. The host institution is one of the best in the Egyptological field. It has huge experience in editing epigraphic and iconographic primary sources, in project management in Egypt, and has a strong network. The allocation will contribute to the research activities of the host laboratory while developing the own candidate network of contacts through the dissemination/publication of the results and by organizing a scientific workshop. The candidate will particularly develop skills in: database creation, management, and use, with specific training activities at the host institution; budget management; teaching at the university level; organizing scientific conferences.
Applicability of Data Mining Technique Using Bayesians Network in Diagnosis of Genetic Diseases

This study aims to identify a methodology to aid in the identification of diagnosis for chromosomal abnormalities and genetic diseases, presenting as a tutorial model the Turner Syndrome. So, it has been used classification techniques based in decision trees, probabilistic networks (Naïve Bayes, TAN e BAN) and neural MLP network (Multi-Layer Perception) and training algorithm by error retro-propagation. Described tools capable of propagating evidence and developing techniques of generating efficient inference techniques to combine expert knowledge with data defined in a database. We have come to a conclusion about the best solution to work out the show problem in this study that was the Naïve Bayes model, because this presented the greatest accuracy. The decision - ID3, TAN e BAN tree models presented solutions to the indicated problem, but those were not as much satisfactory as the Naïve Bayes. However, the neural network did not promote a satisfactory solution.
Analysis of CCN activity of Arctic aerosol and Canadian biomass burning during summer 2008

Abstract. The NASA DC-8 aircraft characterized the aerosol properties, chemical composition, and cloud condensation nuclei (CCN) concentrations of the summertime Arctic during the 2008 NASA Arctic Research of the Composition of the Troposphere from Aircraft and Satellites (ARCTAS) campaign. Air masses characteristic of fresh and aged biomass burning, boreal forest, Arctic background, and anthropogenic industrial pollution were sampled. Observations were spatially extensive (50–85° N and 40–130° W) and exhibit significant variability in aerosol and CCN concentrations. The chemical composition was dominated by highly oxidized organics (66–94% by volume), with a water-soluble mass fraction of more than 50%. The aerosol hygroscopicity parameter, κ, ranged between κ = 0.08–0.32 for all air mass types. Industrial pollution had the lowest κ of 0.08 ± 0.01, while the Arctic background had the highest and most variable κ of 0.32 ± 0.21, resulting from a lower and more variable organic fraction. Both fresh and aged (long-range transported) biomass burning air masses exhibited remarkably similar κ (0.18 ± 0.13), consistent with observed rapid chemical and physical aging of smoke emissions in the atmosphere, even in the vicinity of fresh fires. The organic hygroscopicity (κorg) was parameterized by the volume fraction of water-soluble organic matter (εWSOM), with a κ = 0.12, such that κorg = 0.12εWSOM. Assuming bulk (size-independent) composition and including the κorg parameterization enabled CCN predictions to within 30% accuracy for nearly all environments sampled. The only exception was for industrial pollution from Canadian oil sands exploration, where an external mixture and size-dependent composition was required. Aerosol mixing state assumptions (internal vs. external) in all other environments did not significantly affect CCN predictions; however, the external mixing assumption provided the best results, even though the available observations could not determine the true degree of external mixing and therefore may not always be representative of the environments sampled. No correlation was observed between κorg and O : C. A novel correction of the CCN instrument supersaturation for water vapor depletion, resulting from high concentrations of CCN, was also employed. This correction was especially important for fresh biomass burning plumes where concentrations exceeded 1.5×104 cm−3 and introduced supersaturation depletions of &amp;amp;geq;25%. Not accounting for supersaturation depletion in these high concentration environments would therefore bias CCN closure up to 25% and inferred κ by up to 50%.
FALSE TWIST TEXTURING MACHINE

The invention relates to a false twist texturing machine for carrying out the false twist texturing of several synthetic fibers in a number of processing locations respectively having several supply devices, a primary heating device, a cooling device, a false twist unit, a secondary heating device and a winding device. A winding module is provided for accommodating the winding devices, and a process module is provided for accommodating the false twist units. A doffing passage is formed along the winding module, and a servicing passage is formed along the process module. In order to realize a short threadline, the process module and the winding module are assembled to form a frame part situated between the servicing passage and the doffing passage. The thread transition from the process module to the winding module is formed by the secondary heating device oriented in a horizontal direction so that the thread is guided between the false twist unit and the winding device on the frame part in an essentially U-shaped threadline.