SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Unravelling cross-presentation pathways using a chemical biology approach

Immune therapies are therefore currently being pursued to reinvigorate the immune reaction against tumours. This is not trivial, as the right type of immune cells must be activated against a tumour-specific antigen. One method to achieve this is by targeting tumour antigens to certain cross-presentation-promoting receptors on antigen presenting cells. The most intriguing of these is the mannose receptor (MR) as the method by which it does this is unknown.  
This glycoprotein-binding receptor appears to have two functions on APCs: general uptake-enhancement and, in certain isolated cases, cross-presentation-enhancment. What ligand parameters are important in causing cross-presentation enhancement is not known. Current tools, such as anti-MR antibodies and randomly glycosylated ligands fail to selectively enhance cross-presentation. The main aim of this proposal is to determine what structural parameters of the glycoprotein antigen result in enhanced cross-presentation upon MR-ligation. 
I will synthesise a library of biologically traceable single glycoform ligands - with controlled variation in glycan nature, stoichiometry and positioning - for the MR and study differences in uptake, routing and antigen presentation. 
A 2nd aim is to uncover what happens to the antigen after uptake by the MR. I.e. whether changes in antigen routing and proteolysis are responsible for enhanced cross presentation of different glycoforms. A 3rd aim is to develop a new method to study the kinetics of surface appearance of epitopes without T-cell reagents to quantify differences between glycoforms. 
With this approach I aim to gain new insight into methods for enhancing cross-presentation resulting in improved immune therapies against cancer. My background in carbohydrate and protein modification chemistry will provide the toolkit to synthesise the relevant reagents and my background in immunology will ensure the successful immunological validation of the synthetic single glycoforms.
A multivariate CBM model with a random and time-dependent failure threshold

Abstract In a condition-based maintenance setting, the degradation of an item is usually represented by several condition variables, and they can be combined into a composite condition variable. In this case, the functional failure threshold associated with the composite condition variable is usually not a fixed and known constant. It is an open issue to model the failure threshold and accordingly determine a threshold of preventive maintenance (PM). This paper addresses this issue. The condition variables are combined using a weighted power model, the failure threshold is represented by the Gaussian process model, and the PM threshold is determined by two approaches. Based on the gamma process and stress–strength interference models, the distributions of time to failure and to the PM threshold are derived, respectively. The appropriateness of the approach is illustrated by a real-world example.
Next-Comm: event-driven design approach to achieve maximum energy efficiency for the next generation digital communication circuits”

Dr. Christos Vezyrtzis is currently employed in the US as an IBM Research Staff Member, after concluding his PhD at Columbia University in the City of New York! Instead of a life-long career in the US, he decided to take the step back to Europe. Through his unique expertise in continuous-time digital signal processors, he will acquire a career in Europe, establishing himself in the field of next-generation communication circuits. 
The primary technical focus is the novel event-driven design approach to achieve maximum energy efficiency for the next generation digital communication circuits. This will lead to a drastic reduction in power cost, environmentally friendly products and significantly prolonged operation time. The novel radios will have a cleaner emitted spectrum, less interference which leads to higher data rates (closer to the theoretical limit). Improvement in energy-efficiency will help the European market get one step ahead of the competitors, mainly in the US and Asia.
Infineon, as the host organization, is highly supportive to this idea gaining one of the top-level experts in asynchronous and continuous-time digital circuits to strengthen the European Semiconductor Industry. Such effort will greatly benefit from Dr. Vezyrtzis’ extensive skills in the new and upcoming field of continuous-time digital circuits. The Marie S. Curie funding gives Dr. Vezyrtzis the freedom to develop his own strategy to re-integrate in Europe while gaining additional industry experience and support an application oriented research project for future communication solutions. 
 The career goal for the researcher is to find a long-term position in European research, starting in industry to get an additional set of capabilities while investing his know-how in the project. At the end of the Marie S Curie fellowship he will have clarity about his further path in Europe – being qualified for industry as well as for academia.
Petrographic and volatile signatures of primitive and differentiated achondrites

The “Petrographic and vOlatile SignaturEs of prImitive and Differentiated achONdrites” proposal aims to determine the water content and its hydrogen isotopic composition in nominally anhydrous minerals (NAMs), from a range of achondrite meteorites, using a combination of three techniques, namely transmission infrared spectroscopy, reflectance spectroscopy and nano secondary ion mass spectrometry. The leading goal is to estimate bulk-parent body volatile abundances of achondrites, which were among the first planetesimals formed in the Solar System, to develop a robust understanding of the distribution and source(s) of water in the inner Solar System. This project also aims at developing reflectance spectroscopy as a possible tool for direct/indirect estimation of water content by cross-calibration of multi-techniques. Four tasks have been elaborated to perform this proposal: 1) petrographic characterization of achondrites, 2) transmission and reflectance spectroscopy of achondrites, 3) secondary ion mass spectrometry of achondrites, 4) dissemination of results. The proposed study will be the first comprehensive study of its kind, combining a new approach using multi-techniques methodology for measuring volatile abundances and isotopic composition in NAMs, exploiting recent improvements in analytical techniques, developing new protocols for reflectance spectroscopy, and studying a range of planetary materials never studied before. The results from our work would make timely key contributions towards the ongoing debate of ‘wet’ vs. ‘dry’ scenario for accretion of volatiles in the inner Solar System as well as implications for the timing of water accretion into planetesimals, which is essential for developing dynamical models of Solar System formation. As such, this study is vital to comprehend the early stages of our Solar System evolution but also to understand other planetary systems in terms of habitability, as water is a key component for the emergence of life.
NETwork of small "in situ" WAste Prevention and management initiatives

NETWAP project will generate a set of guidelines for national and local governments, that will help them implement, based on the practical experiences with pilot actions,new methodologies in the field of sustainable waste management, with particular attention to the local and community dimension. These guidelines will be released in the form of a position paper including elements on how to set up the regulatory requirements in each territory, for the application of economic management models and environmentally sustainable procedures. In addition, there will be references on how to establish, starting from the analysis on economic sustainability, funding mechanisms to sustain economically the management models.
Creation of a short-term export development plan and long-term business strategy for international activities AKAT-GROUP Sp. z o.o.

The project consists of the development by an external specialised company, selected in the procedure for awarding the contract, respecting the principles of competitiveness, a multi-annual business strategy (2018-2022) and an export development plan (2018-2019), which will serve to internationalise the applicant’s business activity. Strategy papers will cover at least two foreign markets: Russian and Norwegian. It is assumed that both strategy papers will identify other markets in which the applicant should exist in order to optimise the business dimension of the company’s internationalisation. The strategy will include a comprehensive and detailed analytical part, including multiple types and objects of analysis, and a proposal (recommendation) part indicating specific, dedicated ways of entering and operating the target market (marketing tools, pricing strategy, etc.) which will have a key impact on optimising the company’s costs and profits in the long term. The strategy will include: 1. the date of commencement and completion of the preparation of the document; 2) the period for which the document was drawn up (more than 24 months); 3. the analytical part in the foreign country concerned: — SWOT analysis – PEST analysis – Porter’s 5 forces analysis A3 – benchmarking competition analysis – quantitative data on target markets. 4) the recommendation part in a given foreign country: — selection of optimal methods of communication, – selection of appropriate means of promotion, – recommendation to adapt the offered products to the requirements of the foreign markets (including the need to obtain legal assistance, adopt a specific pricing strategy, standardise services and record contract patterns, assistance from foreign and national advisers, specialists, graphic designers, advertising agencies), – recommendation in terms of opening new business channels
Nature based solutions for re-naturing cities: knowledge diffusion and decision support platform through new collaborative models

Based on a detailed mapping of urban challenges and relevant nature-based solutions (NBS), Nature4Cities aims at developing complementary and interactive modules to engage urban stakeholders in a collective-learning process about re-naturing cities, develop and circulate new business, financial and governance models for NBS projects, as well as provide tools for the impacts assessment, valorisation and follow-up of NBS projects. The different modules are:
•	a database of generic NBS and associated environmental, economic and social performances  
•	an observatory of NBS projects best practices / case studies 
•	a set of innovative business, financial and governance models for the deployment of NBS in a range of different contexts, together with a tool to help urban stakeholders identify eligible models regarding their NBS project contexts 
•	a NBS project impact assessment toolbox providing capabilities for environmental, economic and social impacts evaluation at different stages in the project development cycle from opportunity/feasibility studies to design steps and project follow-up). This toolbox will built on a range of tools, from generic indicator-based assessment for early project stages, down to detailed modelisations of NBS behaviors.
These modules that already have a proper purpose on their own, will furthermore be integrated in a NBS dissemination and assessment self-learning platform [N4C Platform] to assist NBS project developers along the entire life cycle of their projects from opportunity studies and project definition down to performance monitoring.
Nature4Cities indicators, methodologies, tools and platform will be field tested in real working environments and on real nature-based solution projects and developments in selected cities in Europe, which will be partners of the project and engage their technical urban and environmental planning teams.
REMOTE-CONTROLLED DOOR LOCKING SYSTEM FOR AUTOMOTIVE VEHICLE

Bei einer Einrichtung zur berührungslosen fernbedienbaren Türverriegung insbesondere einerZentralverriegelung von Kraftfahrzeugen ist ein durch den Fahrer transportierbarer und betätigbarer, eine elektromagnetische Strahlung aussendender Kleinsender vorgesehen. In dem Kraftfahrzeug ist mindestens ein Empfänger angeordnet, der die ausgesendete elektromagnetische Strahlung empfängt und die Betätigung der Türverriegelung auslöst. Der Kleinsender umfaßt einen Speicher (Diodenmatrix 3) für einen Code sowie einen Modulator (Encoder 1, Flankenmodulator 9, Sendestufe 16) zur Modulation der elektromagnetischen Strahlung mit dem Code. In dem Empfänger sind ein die modulierte Strahlung empfangendes Empfangsteil, ein Demodulator (monostabile Kippstufe 20, D-Flip-Flop 21) und ein den demodulierten Code mit einem in einem Codespeicher gespeicherten Code vergleichenden Vergleicher (28) vorgesehen. Mit dem Vergleicher (28) steht ein Stellglied (31) für das Schloß in Wirkverbindung. In dem Sender ist der Modulator zur Modulation der Strahlung mit einer Pulscode-Pulslage-Modulation (PCM/PPM) ausgebildet. Dem steht in dem Empfänger ein Demodulator zur Demodulation der PCM/PPM modulierten Strahlung gegenüber.
A Critical Revision of the Nano-Morphology of Proton Conducting Ionomers and Polyelectrolytes for Fuel Cell Applications

A few aspects of the nano-morphology of hydrated Nafion and other ionomers and polyelectrolytes in their acid form are revisited by examining the evolution of small angle X-ray scattering (SAXS) data which are recorded for a wide range of water volume fractions (Φwater ≈ 7–56 vol%). A consistency check with the recent “parallel cylinder model” discloses that this is most likely biased by a large uncertainty of the experimentally determined water content. We rather find our data to be consistent with locally flat and narrow (around 1 nm) water domains. The formation of relatively thin water “films” is suggested to be a common feature of many ionomers and polyelectrolytes, and the underlying driving force is most likely electrostatics within these highly dissociated systems. The water films may act as a charged (e.g., with positive protonic charge carriers) “glue”, keeping together the oppositely charged polymer structures. While this interaction tends to produce flat morphologies, the formation process is suggested to be constraint by limited conformational degrees of freedom of the corresponding polymer and the interactions between polymer backbones. This may leave severe tortuosities on larger scales which depend on the sample history (including swelling, de-swelling, aging, stretching, and pressing).
FEniCS-HPC: Coupled Multiphysics in Computational Fluid Dynamics

We present a framework for coupled multiphysics in computational fluid dynamics, targeting massively parallel systems. Our strategy is based on general problem formulations in the form of partial differential equations and the finite element method, which open for automation, and optimization of a set of fundamental algorithms. We describe these algorithms, including finite element matrix assembly, adaptive mesh refinement and mesh smoothing; and multiphysics coupling methodologies such as unified continuum fluid-structure interaction (FSI), and aeroacoustics by coupled acoustic analogies. The framework is implemented as FEniCS open source software components, optimized for massively parallel computing. Examples of applications are presented, including simulation of aeroacoustic noise generated by an airplane landing gear, simulation of the blood flow in the human heart, and simulation of the human voice organ.
Algorithms Solving the Matching Cut Problem

In a graph, a matching cut is an edge cut that is a matching. Matching Cut is the problem of deciding whether or not a given graph has a matching cut, which is known to be NP-complete. This paper provides a first branching algorithm solving Matching Cut in time $$O^*2^{n/2}=O^*1.4143^n$$ for an $$n$$-vertex input graph, and shows that Matching Cut parameterized by vertex cover number $$\tau G$$ can be solved by a single-exponential algorithm in time $$2^{\tau G} On^2$$. Moreover, the paper also gives a polynomially solvable case for Matching Cut which covers previous known results on graphs of maximum degree three, line graphs, and claw-free graphs.
Militant science. european physicists and the emergence of transnational radical science movements

MISHA’s research objective is to understand the transnational emergence and flourishing of radical science movements with a particular focus on the physics communities in Italy, France, United Kingdom, and the United States. I aim at elucidating the dynamic of the two-way transfer of knowledge and people between the US and Europe. The project consists of the following research actions: archival research (e.g., Niels Bohr Library & Archives, American Institute of Physics, Cambridge University Library, Wellcome Library, Archives de Jussieu, Sorbonne, Fondazione Lelio e Lisli Basso, University of Rome La Sapienza, Archivio della Società Italiana di Fisica); systematic analysis of written sources, (European and American journals, monographs, and translations of essays and articles); reconstruction of scientific networks from the examination of conferences proceedings, summer schools programs and lectures, and seminars, as well as programmatic documents; reconstruction of institutional and informal networks (political militancy, correspondences, internal reports); definition of the epistemological and political features of the debate on non-neutrality in science at transnational European level. On the methodological side, I will employ the most advanced conceptual tools of transnational history and political epistemology to provide an integrated narrative able to combine political, philosophical, and historical analysis.
Worker 4.0 – connected. empowered. safe and healthy. the first intelligent and interoperable platform based on ai and wearable/iot devices for real-time workers safety and health monitoring

Artificial intelligence is a key priority for the European Union and is a field in which experts are in high demand. US tech giants are paying huge salaries for AI and machine learning talent, creating the potential for an EU brain-drain in the field. European AI research is well funded, but European ‘deep tech’ SMEs are generally less successful than the Americans at leveraging AI R&D into successful commercial ventures.  
WearHealth is an intelligent decision support system that can use any 3rd party wearables and IoT devices. 3rd party hardware is integrated into our proprietary cognitive technologies to build an intelligent software platform that can identify markers of workers’ occupational risks, health, workload, and work efficiency. With these insights, businesses will be able to detect and predict worker safety and health risks, thus preventing accidents and managing their workforce to improve productivity and operational efficiency.
WearHealth’s disruptive character is defined by its unparalleled performance, interoperability, and potential utility in a wide variety of market verticals, unlike any competitive commercial solutions. Following 10 years of R&D at the Artificial Intelligence Institute at the University of Bremen, our team has created a self-learning platform that improves as it analyzes new streams of data.
EU industry leaders are already paying to use our version 1.0 platform for worker safety applications in transportation and energy.
The goal of this project is to further segment target user groups and refine our go-to-market strategy for WearHealth version 2.0, guided by feedback from large-scale target user and client interviews and surveys.
We project generating €40M annual revenue by year 3 after market launch, and directly creating 180 jobs over the same time period.
EnvironmentAl integrated, multilevel knoWledge and approaches to counteract critical AIR pollution events, improving vulnerable citizens quality of life in Central Europe Functional Urban Areas

Air pollution is both an environmental & a social problem and is considered a common challenge for CE territories in particular dealing with Severe Air Pollution Episodes.AWAIR aims at improving environmental management capacity in CE through  promotion&adoption of agreed measures&strategies able to reduce SAPEs impacts on environment & human health in particular of vulnerable people.Transnational approach to a transnational problem with a local application, AWAIR answers to the lack of coordination of environmental policies between core urban areas and their surroundings: it defines a common,transnational approach for Mitigation&Adaptation actions’management at Funtional Urban Area that will be used as framework for each FUA at local level.Those potential M&A actions can be of different kind,depending on identified characteristics of FUA, translated in ad hoc action plans.Screening of novel solutions & tools is conducted at wide scientific level (BAT) & at EU funded projects level. Specific monitoring tools of the effectiveness of actions at each FUA are foreseen. AWAIR also aims at promoting innovative preventive approach with introduction of new indicators (e.g. ultrafine particles, black carbon) & inclusion of air quality forecasting systems among actions established for health effect’s prevention during SAPEs.The whole project is inspired by a participative approach,since project conceiving,of stakeholders involvement,that foresees feedbacks and inputs from them.AWAIR organises ad hoc stakeholder plans to deeply identify, address &reach each category of them in a customized way  ensuring knowledge transfer at wider level: other FUAs, cities in CE &EU(spread FUA model), local administrators&representative from vulnerable groups (guidelines&trainings) &vulnerable citizens (alert system).Pervasive,wide-ranging communication is structured to guarantee maximum AWAIR visibility& information on opportunities in FUA-cities but also for other citizens in other cities
Genetics of pancreatitis with a focus on the pancreatic ducts.

Genetic risk for acute pancreatitis (AP), recurrent acute pancreatitis (RAP) and chronic pancreatitis (CP) are increasingly recognized. The exocrine pancreas is composed of both acinar cells and duct cells, with genetic factors associated with AP, RAP and CP linked to one cell type or the other. Increased susceptibility to pancreatitis occurs when the normal physiological mechanisms that allow the pancreas to respond to common stresses or injury are altered. Currently, most our knowledge about genetics focuses on three genes that play critical roles in pancreatic function (PRSS1, CFTR, SPINK1) such that isolated defects lead to disease. However, recent data suggest that more complex combination of genetic and environmental factors are also as important, or more important than Mendelian genetic risk. Understanding of complex interactions requires modeling of these factors so that the response to stresses or injury can be simulated and critical interactions understood. A simple duct cell model is given to illustration the relationship between CFTR, CASR, aquaporins, claudins, and SPINK1, and how they interact. The role of CFTR variants in pancreatic diseases is then discussed.
Reliability-based maintenance scheduling of haulage system of drum shearer

Drum shearer is the most important component of production chain in longwall mining. This machine is driven along the face by a powerful haulage system. In this paper, the reliability of haulage system of shearer has been analysed. The result showed that Time Between Failures (TBF) data of this system obeys the three-parameter Weibull distribution. On the basis of the achieved reliability model, the Preventive Maintenance (PM) scheduling has been suggested for different reliability levels. The reliability-based maintenance intervals for 90, 80, 70 and 50% reliability are 19.4, 35, 49 and 96.8 h, respectively. If 35 h are considered as the PM intervals, mean TBF will be increased by 16.2%.