SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Sobrevida en pacientes con cirrosis de acuerdo con su etiología. Cohorte retrospectiva

Introducción: la cirrosis es el estadio final de enfermedades hepáticas crónicamente progresivas de diferentes etiologías. Es una enfermedad frecuente, con una prevalencia variable en cada país. Su pico de incidencia se presenta entre los 40 y 50 años, predominantemente en hombres.&#x0D; Objetivos: comparar una cohorte de pacientes con diagnóstico de cirrosis, evaluar sus complicaciones y sobrevida de acuerdo con su etiología, describir los aspectos clínicos y de laboratorio, y determinar el papel del hígado graso.&#x0D; Materiales y métodos: se realizó un estudio de cohorte retrospectiva, en donde se incluyeron pacientes que asistieron a consulta especializada de hepatología en el centro de enfermedades hepáticas y digestivas (CEHYD), en la ciudad de Bogotá, durante enero de 2010 y junio de 2019.&#x0D; Resultados: se revisaron un total de 1200 historias clínicas (56,8 % mujeres). No se evidenció diferencias estadísticamente significativas en las medianas de sobrevida entre los grupos por etiologías, sexo, presencia o no de complicaciones, o Child. Se evidenció que entre mayor edad en el diagnóstico de cirrosis, el riesgo de muerte es mayor; HR 1,04 (IC 95 % 1,02-1,075). Por cada mes que aumenta el seguimiento se reduce el riesgo de muerte en 90 %; HR 0,1 (IC 95 % 0,03-0,29). Por cada mes que aumenta el seguimiento de las complicaciones se reduce el riesgo de muerte en 2 %; HR 0,98 (IC 95 % 0,97-0,99).&#x0D; Conclusiones: La sobrevida por etiología fue similar en los diferentes grupos. La esteatohepatitis no alcohólica (NASH) fue la principal causa de cirrosis en esta cohorte. Se deben orientar esfuerzos a su diagnóstico y manejo en fases tempranas.
<b>Sima, Alexander:</b> <i>Die sabäischen Inschriften aus Ẓafār.</i> Aus dem nachgelassenen Manuskript herausgegeben von Norbert Nebes und Walter W. Müller. Wiesbaden: Harrassowitz 2020. VIII, 115 S. m. Abb. 8° = Jenaer Beiträge zum Vorderen Orient 10. Brosch. € 58,00. ISBN 978-3-447-11441-7.

Article Sima, Alexander: Die sabäischen Inschriften aus Ẓafār. Aus dem nachgelassenen Manuskript herausgegeben von Norbert Nebes und Walter W. Müller. Wiesbaden: Harrassowitz 2020. VIII, 115 S. m. Abb. 8° = Jenaer Beiträge zum Vorderen Orient 10. Brosch. € 58,00. ISBN 978-3-447-11441-7. was published on June 1, 2022 in the journal Orientalistische Literaturzeitung (volume 117, issue 1).
[Effects of metformin on the estrogen-induced proliferation and the expression of ER in human endometrial cancer cells].

To assess the effects of metformin on estrogen-induced proliferation of human endometrial cancer cell lines and investigate whether metformin could regulate the expression of ER and estrogen-dependent proliferative genes.Human endometrial cancer cell lines Ishikawa and HEC-1A underwent treatment with metformin at various concentrations (0.5, 1, 5, 10, 15, 20, 25 and 30 mmol/L) for different durations (24, 48 and 72 hours), followed by assessment of cell proliferation by methyl thiazolyl tetrazolium (MTT) assay. Ishikawa and HEC-1A cells were exposed to 17β-estradiol (1×10(-6) mol/L) alone or in combination with metformin (5 mmol/L) for 24 hours. Cell proliferation was assessed by 5-bromo-2-deoxyuridine (BrdU) assay. Twenty-four hours after metformin treatment at the concentrations of 1, 5 and 15 mmol/L, the expression levels of estrogen-dependent proliferative genes c-fos and c-myc were determined by real-time quantitative fluorescent PCR (real-time FQ-PCR). Western blot analysis was performed to assess the effects of metformin on the expressions of estrogen receptors.As revealed by MTT assay, at different time points of metformin treatment at different concentrations, the proliferation rates of both cell lines were inhibited in a dose-dependent and time-dependent manner between metformin groups and the control group (P < 0.05). BrdU assay showed that the proliferation rate of Ishikawa and HEC-1A cells exposed to 17β-estradiol (1×10(-6) mol/L) in combination with metformin (5 mmol/L) was (62±7)% and (72±6)%, respectively, while that in 17β-estradiol groups was (124±16)% and (109±5)%, respectively, with significantly statistical differences (P < 0.01). By real-time FQ-PCR tested, the expression levels of c-fos and c-myc in both cell lines gradually declined subsequent to metformin treatment at different concentrations (1, 5 and 15 mmol/L). As compared with the control group, the c-myc and c-fos expressions in both cell lines in metformin groups had significant differences (P < 0.05) except for the c-myc expression of the concentration of 1 mmol/L in HEC-1A cell line (P = 0.074). Western blot analyses showed that with the increasing concentrations of metformin, the ERa expression was markedly down-regulated, while ERβ expression was up-regulated in the metformin group at the concentrations of 5 mmol/L and 15 mmol/L, compared to those at the control group, there were significant differences between them, respectively (all P < 0.01).Metformin could inhibit estrogen-mediated proliferation of human endometrial cancer cells, which might be correlated with its regulation of the expressions of estrogen receptors and estrogen-dependent proliferative genes.
BlueConnect 2 - "promoting the provision of services to cross-border businesses in priority blue and green sectors"

The objective of Blueconnect2 is to integrate the projects already completed as part of the previous BlueConnect and Marittimotech initiatives, further developing and structuring the potential of the cross-border dimension for the innovative entrepreneurial system that already exists in the cooperation area, in order to position companies in the blue and green supply chain on regional, national and international markets, thereby actively integrating them into innovation processes.

 The process that has been launched will help existing companies to acquire services to become stronger and further develop (diagnosis, consulting on access to specialised structures, access to facilitator networks, studies for the commercial positioning of products, business plans, foresight studies) in the priority cross-border supply chains, especially related to blue and green growth. During the project period, particular attention will be paid to defining the priorities of the innovation axes identified in the Blueconnect project.

 BlueConnect 2 aims to:
 - provide companies with a tool to boost their business.
 - support them in their efforts to promote innovation and seek new commercial opportunities.
 - create a link with the port operators who participated in the Blueconnect project.
 - offer innovative solutions in the short and medium term to meet the needs identified by the Blueconnect maritime operators.
Coating cylinder bores with ultra thin solid lubricant phase

Cylinder bores (16) are coated by preparing the cylinder bore surface to expose fresh metal free of contamination, generating through a nozzle (13) from a highly pressurised supply of emulsion a hollow conical spray consisting of fine mist droplets (38) of a solid lubricant emulsion, the conical spray having an effective base with a diameter greater than the diameter of the cylinder bore, and moving by means (15, 20, 21) the apex of the conical spray (28) along the axis of the bore at a uniform speed to deposit a coating of the emulsion on the interior of such cylinder bore in a thickness of no greater than 30 microns. The lubricant emulsion may consist of a mixture of molybdenum disulfide, boron nitride and graphite in a thermoset or thermoplastic polymer resin base. The nozzle may have diverging and converging conical surface sections (32, 33) to induce the flow of emulsion to exit from the nozzle with a hollow interior.
G.A. Cohen and what type of society we ought to seek

In this thesis I attempt to clarify and evaluate G. A. Cohen’s positive contribution to the question of what type of society we ought to seek, following his turn from Marxism to normative political philosophy. I specifically focus on clarifying and evaluating certain views that appear in his critical engagement with Ronald Dworkin and John Rawls, and in his positive vision of society as set out in Why Not Socialism? I interpret Cohen as holding that, in principle, we ought to seek a society that reflects equal access to advantage (or some other luck egalitarian principle of equality of opportunity), Pareto-efficiency, freedom of occupational choice, and a principle of community that, by means of voluntary non-state agency, significantly tempers inequalities consistent with luck egalitarianism. With respect to evaluative matters, I argue: (i) that we ought not to embrace equal access to advantage but rather an alternative luck egalitarian principle of equality of opportunity where opportunities are specified in terms of resources; (ii) that although equality of opportunity, Pareto-efficiency and freedom of occupational choice might be co-obtainable in principle, they are not coobtainable in practice; and (iii) that in practice equality of opportunity ought to be constrained by a sufficiency qualification rather than by Cohen’s community principle. In addition, I interpret a concession from Cohen about Paretoefficiency often trumping equality of opportunity, in practice, in terms of a pluralist distributive ethic that combines telic egalitarian and telic prioritarian beliefs. I defend the plausibility of this ethic to some extent, but ultimately come to embrace a sufficiency-constrained luck egalitarianism that secures a decent life for all by means of state coercion, and which minimizes the unfairness of the prudent having to bear the costs of other’s imprudence.
Lançamento de novos serviços

O objetivo do projeto é aumentar as vendas e a quota de mercado dos serviços de OPR e reforçar a competitividade através da expansão dos serviços de manutenção existentes e da sua distribuição em novos mercados de exportação. Tal permitirá que a MRO Magnética alcance significativamente mais contratos de manutenção a longo prazo para toda a frota das companhias aéreas.
Analysis of the skill and methods of laparoscopic operation in the treatment of acute cholecystitis

Objective:To discuss the skill and methods of laparoscopic cholecystectomy in the treatment of acute cholecystitis.Methods:The clinical data of 3 700 patients who underwent laparoscopic cholecystectomy between Feb.2000 and Nov.2012 were retrospectively analyzed,including 485 patients who suffered from acute cholecystitis.Results:Laparoscopic cholecystectomy for acute cholecystitis was performed successfully in 461 cases,23 cases were converted to open surgery,1 case received T-tube drainage due to bile duct injury.The remainder were placed abdominal drainage tube.No serious complications such as hemorrhage,bile leakage occurred postoperatively.Abdominal drainage tubes were removed 2-4 d after operation,and all patients were discharged from hospital.Conclusions:Along with the maturity of laparoscopic technology and the perfection of equipment and appliances,bile duct injury and other complications can be effectively prevented,laparoscopic cholecystectomy in the treatment of acute calculous cholecystitis is safe and reliable based on sufficient exposure of the Calot triangle,distinction the relationship of the three tubes,grasping the indications for converting to open surgery,paying attention to skills and methods in operation.
Renewable Energies Transfer System

The ”RETS: Renewable Energies Transfer System” project has grown up out of a local experience of economic development through renewable energies (RES) in Northern Alsace (France).

The project aims to tackle the challenges of renewable energies for local and regional authorities (and in particular those with less than 25,000 inhabitants) in association with the expertise of existing competency centres that produce research and provide services on RES. These small sized authorities have to combat issues linked to their territorial competitiveness and access to project management skills for the implementation of complex projects (energy–mix).

The main objective of RETS is to improve the knowledge and competencies of local and regional policymakers (decision makers, civil servants …) in renewable energies, so as to facilitate the deployment of coherent and value added strategic renewable energies policies. This will be realised through the creation of a European community for local
authorities on RES, comprised of two key elements: physical tools for meeting and exchanging viewpoints and a virtual platform for collaborative exchange and transfer of good practice through an innovative online approach.

The RETS partnership counts 12 partners from 9 EU Member States: France, Germany, Hungary, Italy, Portugal, UK, the Netherlands, Romania, and Slovenia. It has been developed with the idea of obtaining partners with different types and levels of experiences in the deployment of RES and sustainable management. The panel contains local authorities, universities, energy agencies and associations, more or less advanced in their policy and experiences.

The core RETS activities concern the creation of simple usable tools for local authorities in order to help them make informed choices for the implementation of the right renewable energy strategy within their territories: 
- Collection and analysis of regional RES initiatives and production of a good practice guidebook
(45 good practices collected and 20 transferred)
- Study visits (6) to exchange on ideas and practices between network members
- Tailored RES seminars for local authorities (10 seminars) to transfer knowledge, good practices and stimulate policy implementation
- Creation of an online RES community bringing together local authorities and RES experts on a collaborative tool, allowing them to find, exchange, discuss and transfer information on RES in an innovative way (publication of 25 articles on the web portal). 
- Dissemination of the results using both traditional (3 conferences, paper publications (leaflet, brochure), 10 newsletters, press releases) and new forms of communication (website, online collaborative tool).

The immediate project result is expected within the members of the consortium and their regional local authority network contacts. RETS will then rapidly have a wider reach through the diffusion of its good practices and knowledge via the RETS web portal and guidebook.
SMALL MOLECULE CANCER TREATMENTS THAT CAUSE NECROSIS IN CANCER CELLS BUT DO NOT AFFECT NORMAL CELLS

A method of treating cancer in a subject, including: providing a subject having a plurality of cancer cells; and administering to the subject, a therapeutically effective amount of a composition including: an HDM-2 binding component; and a membrane resident component, the membrane resident component bound to the HDM-2 binding component. Also provided are a method of selectively necrosing cancer cells, a method of causing membranolysis in cancer cells, and a cancer treatment composition.
Re-irradiation of adenoid cystic carcinoma: Analysis and evaluation of outcome in 52 consecutive patients treated with raster-scanned carbon ion therapy

Treatment of local relapse in adenoid cystic carcinoma (ACC) following prior radiation remains a challenge: without the possibility of surgical salvage patients face the choice between palliative chemotherapy and re-irradiation. Chemotherapy yields response rates around 30% and application of tumouricidal doses is difficult due to proximity of critical structures. Carbon ion therapy (C12) is a promising method to minimize side-effects and maximize re-treatment dose in this indication. We describe our initial results for re-irradiation in heavily pre-treated ACC patients.Patients treated with carbon ion therapy between 04/2010 and 05/2013 (N=52pts, median age: 54 a) were retrospectively evaluated regarding toxicity (NCI CTC v.4), tumour response (RECIST) and control rates. 48pts (92.3%) received carbon ions only, 4pts received IMRT plus C12.4pts were treated following R1-resection, 43pts for inoperable local relapse. Most common tumour sites were paranasal sinus (36.5%), parotid (19.2%), and base of skull (17.3%). Pts received a median dose of 51GyE C12/63Gy BED and cumulative dose of 128Gy BED [67-182Gy] after a median RT-interval of 61months. Median target volume was 93ml [9-618ml]. No higher-grade (>°II) acute reactions were observed, 7pts showed blood-brain-barrier changes (°I/II: 8pts; °III: 2pts), 1 pt corneal ulceration, xerophthalmia 7pts, °IV bleeding 1 pt, tissue necrosis 2pts, otherwise no significant late reactions. Objective response rate (CR/PR) was 56.6%. With a median follow-up of 14months [1-39months] local control and distant control at 1a are 70.3% and 72.6% respectively. Of the 18pts with local relapse, 13pts have recurred in-field, 1 pt at the field edge, 3pts out of field, and one in the dose gradient.Despite high applied doses, C12 re-irradiation shows moderate side-effects, response rates even in these heavily pre-treated patients are encouraging and present a good alternative to palliative chemotherapy. Though most local recurrences occur within the high-dose area, further dose escalation should be viewed with caution.
Organic phosphorus immobilization in microbial biomass controls how N2-fixing trees affect phosphorus bioavailability in two tropical soils

Eucalyptus is the tree most widely planted in tropical countries to satisfy growing demand for wood products, but high yields require high fertilizer inputs. Introducing N2-fixing trees (NFT), such as Acacia mangium, has been proposed to improve soil fertility and aboveground tree biomass in Eucalyptus plantations. In addition to N inputs, NFT species may increase plant P nutrition through increased rates of organic P (Po) cycling. However, the positive effect of acacia on soil P availability and plant P nutrition was found to vary substantially between sites. The ability of acacia to improve P bioavailability might mainly depend on Po sequestration in microbial biomass, preventing Po mineralization by phosphatases and efficient Po recycling. This hypothesis was tested at two tropical sites, Itatinga (Brazil) and Kissoko (Congo) by measuring inorganic phosphate (Pi), Po and enzyme-labile Po in bicarbonate extracts from the topsoil collected from plots with Eucalyptus, acacias, or native vegetation. We used bicarbonate enzyme-labile Po after soil autoclaving as an indicator of microbial Po, and a Eucalyptus bioassay to measure the actual P bioavailability for Eucalyptus seedlings. At Itatinga, bicarbonate-Pi was very low, while Po was the main P form. Enzyme-labile Po was very weak in intact soils and high in autoclaved soils, indicating high immobilization in microbial biomass. At Kissoko, Po was highly enzyme-labile in both intact and autoclaved soils, especially from acacia plots, suggesting very low Po immobilization in microbial biomass. Growth and P accumulations in Eucalyptus seedlings were low in all soils at Itatinga and were the highest in Eucalyptus plants grown in acacia soils at Kissoko. Our results highlight the potential of acacia trees for improving P bioavailability for other tree species if labile Po enrichment in the soil provided by this N2-fixing tree is not locked into the microbial biomass.
D-Band radio 5g network technology

Nowadays there is a shared vision among industry, operators and academy that 5G wireless networks will have to provide wideband wireless access and ubiquitous computing anywhere and at any time. The human life of the majority of the EU citizens will be surrounded by intelligent wireless sensors, which will bring radical changes to the way we live and do things. Supporting this scenario is a challenge for network operators and wireless network infrastructures and it will demand a tremendous performance improvement of medium range wireless infrastructure. This challenge needs to be addressed by a convergence of advanced semiconductor nanotechnology and a robust wireless infrastructure based on meshed networks with seamless fiber performances.

The DRAGON project, through the exploitation of the radio spectrum in D-band (130-174.8 GHz) , will overcome the constraints of current E-band wireless backhaul solutions to achieve a small-form factor and high-capacity radio solution, suitable for massive deployment, that will enable bringing the speed of optical systems to backhaul systems in a cost effective way. The DRAGON project vision and objectives rely on a power efficient and silicon based BiCMOS transceiver analog front end, operating in D-band and enabling cost efficient deployment of telecommunications networks with seamless fiber performance. A beam steering integrated antenna array using an intelligent low-cost packaging technology will be developed for the implementation of the 5G network demo trial on field, with fine beam alignment for facilitating the installation and compensating pole vibration.

The DRAGON consortium has a well-balanced and complementary know-how in the relevant areas for designing and demonstrating the feasibility of a small cell cellular network architecture based on meshed D-band backhaul links. DRAGON will therefore secure Europe’s industrial leadership and pave the way towards innovative 5G telecommunications networks.
Antioxidative Activity and Texture Characteristics of Wanja-jeon with Soybean Powder

This study was conducted to improve the quality of Wanja-jeon, a Korean traditional food utilizing beef. Antioxidative evaluation of the ingredients in Wanja-jeon showed that soybean powder was highest in DPPH, ABTS radical scavenging activities and in reducing power among the food ingredients tested. Since soybean powder demonstrated high antioxidative activity, beef was replaced with soybean powder in Wanja-jeon to increase the antioxidative activity. All antioxidative activities such as DPPH and ABTS radical scavenging activities as well as reducing power increased with increases in the amount of soybean powder replacing beef. In texture analysis, the hardness, chewiness and brittleness of Wanja-jeon were highest when beef was replaced with 20% soybean powder, whereas the springiness and cohesiveness of the Wanja-jeon were highest with 50% of the beef replaced with soybean powder. The Hunter`s color L and b values were highest in Wanja-jeon with 50% soybean powder replacing beef, while the a value of the color was highest in Wanja-jeon with 30% soybean replacing beef.