SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Contribution to the stratigraphy and sedimentology of the Upper Jurassic – lower Eocene succession of the Mitla–El Giddi stretches, west Central Sinai, Egypt

Abstract The present study deals with the stratigraphy, petrography and facies analysis of the stratigraphic succession of Mitla-El Giddi stretches (west Central Sinai, Egypt). Lithostratigraphically, the study area is covered by a thick succession extending from Late Jurassic to early Eocene time. This succession is subdivided into the Masajid Formation (Upper Jurassic (Oxfordian) at the base followed upwardly by the Risan Aneiza Formation (Lower Cretaceous (? Aptian- Albian), the Galala Fm. (Cenomanian), the Abu Qada Formation (lower Turonian), the Buttum Formation (middle Turonian), the Wata Formation (middle–upper Turonian), the Themed Formation (Coniacian–Santonian), the Sudr Chalk (Campanian–Maastrichtian), the Mitla Formation (= Esna Shale) (Paleocene–lower Eocene), the Thebes Formation (lower Ypresian) and the Minia Formation (upper Ypresian) at top. The Aptian – Albian Risan Aneiza Formation is first recorded at G. El Hamra in the study area. As well, a new formational name (the Mitla Formation) is used to describe the Paleocene – lower Eocene unit equivalent to the Esna Shale due to variation in lithology mainly represented by chalky limestone and argillaceous limestone. Many unconformities, represented by variable sedimentologic features, i.e., red paleosols, conglomerates, crustified laminated limestone and glauconitic facies were investigated and mostly attributed to the Syrian Arc System. The petrographic investigations especially for the lithified rocks revealed eighteen limestone microfacies, three dolostone microfacies and four sandstone microfacies, besides the non-lithified shale, sandy shale, clay and marl lithofacies. The recognized facies and their related paleoenvironments document lateral and common vertical transition between inner, middle and outer ramp setting. These facies could be subdivided into eight associations that are related to six depositional environments: peritidal flat/beach clastics, peritidal flat carbonates, lagoonal clastics, lagoonal carbonates, high energy shoal of ooids and patch reefs (oolitic shoal), intertidal-subtidal open marine, storm influenced subtidal open marine (mid-ramp) and hemipelagic outer ramp facies. The study indicates that, the area was controlled by a long-term transgressive phase and several higher order sea level fluctuations during the deposition of the studied succession. The main factors controlling the ramp deposition and the described events are; structure control mainly Syrian Arc deformation, eustatic sea level fluctuations combined with environmental influences such as autochthonous carbonate productivity-siliciclastic supply and paleorelief conditions.
The Predicaments of Bilateral Transfer in Shaoguan City and Its Solutions: From the Perspective of Intellectual Property Strategy

Bilateral Transfer is a major achievement in the liberation of thought discussion as well as a significant move with respect to optimized economic development in Guangdong Province, which is also a substantially theoretical and practical issue in the course of economic development and transfer in Shaoguan. As far as Shaoguan is concerned, we are supposed to positively implement intellectual property strategy, uphold cooperation among industries, universities and research institutes, construct modern enterprises with proprietary intellectual property rights and attach importance to human resources development strategy so as to engender low-lying land effect to personnel development. Simultaneously, it is beneficial for us to learn from Qianghua pattern to establish industrial innovation system in Shaoguan.
Advancing a novel peptide-based therapeutic for pancreatic cancer

Pancreatic cancer is a devastating disease with a median 5-year survival rate of 3-5%. One explanation for the dismal prognosis is the failure of many chemotherapies. Pancreatic tumor cells stimulate neighbouring non-tumor cells (stromal cells) to join and grow around them. This stroma forms a fibrous matrix that promotes 1) aggressive tumor growth, 2) distant metastasis, and 3) form a barrier to chemotherapy and drug delivery. There is a high need to enhance the success of pancreatic cancer treatment by intensively pursuing strategies that target the tumor stroma. We are developing a novel peptide-based drug (AV3), that targets and reduces tumor stroma in pancreatic cancer, and potentially in other fibrosis-associated cancers. We have demonstrated that AV3 reduces fibrosis (>50%) and enhanced the efficacy of chemotherapy in clinically relevant patient-derived xenograft models (achieving up to 80% tumor regression). Thus, our novel peptide has the potential to become a breakthrough add-on to chemotherapy in the treatment of pancreatic cancer. We are a biopharmaceutical company, spun-out in 2016 by the University of Twente. Our mission is to develop novel, targeted, peptide-based drugs to treat pancreatic cancer and other fibrosis-associated cancers and diseases with high unmet medical needs. The management team consists of its pioneering scientific founder and inventor of the technology Prof. Jai Prakash (CEO) and an experienced entrepreneur and drug developer Dr. Bart Metselaar (COO). The FIBROHALT project will (1) create a clear overview of the clinical opportunity for AV3 in pancreatic cancer, 2) develop a strategy to position the drug in the pancreatic cancer market, and (3) create an optimal development strategy, including a de-risk plan for future clinical studies. We will pursue a co-development or licensing deal for AV3 with a pharmaceutical company which will perform late-stage clinical development, obtain EMA/FDA approvals, market and sell AV3.
Overexpression of the vesicular acetylcholine transporter enhances dendritic complexity of adult-born hippocampal neurons and improves acquisition of spatial memory during aging

Aging is marked by progressive impairments in the process of adult neurogenesis and spatial memory performance. The underlying mechanisms for these impairments have not been fully established; however, they may coincide with decline of cholinergic signaling in the hippocampus. This study investigates whether augmenting cholinergic neurotransmission, by enhancing the expression of the vesicular acetylcholine transporter (VAChT), influences the age-related decline in the development of newborn hippocampal cells and spatial memory. We found that enhanced VAChT expression in the hippocampus of mice contributes to lifelong increases in the dendritic complexity of newborn neurons. Furthermore, enhanced VAChT expression improved memory acquisition through an increased use of spatially precise search strategies in the Morris water maze through the course of the aging process. These data suggest that VAChT overexpression contributes to increases in dendritic complexity and improved spatial memory during aging.
Cross-Border Bean Market Performance in Western Kenya and Eastern Uganda

Common bean (Phaseolus vulgaris) is an important grain legume in East Africa, providing food and income to rural households. Smallholder farmers in Kenya and Uganda have widely adopted improved varieties. The demand for common bean in Kenya outstrips domestic supply – hence the need for imports. There is significant border trade on common bean between Kenya and Uganda. This study assesses the efficiency of this trade and evaluates the performance of common bean marketing as well as the associated transport system. Purposive, multistage and systematic random sampling methods were used to select the 210 respondents for the study. SPSS was used for data analysis. Results indicate huge inefficiency in common bean marketing in Kenya and Uganda due to poor road infrastructure and high transaction costs (mostly due to transport costs). Primary market traders incurred a significantly higher cost than terminal market traders. Generally, Ugandan traders operated at relatively higher efficiency than Kenyan traders. However, all the traders made profits far in excess of their common bean transfer costs. The study recommends regional market, infrastructural, and institutional development as well as the abolition of illegal fees in order to improve bean market efficiency in the study area and similar environments.
Durchführung von FuE-Arbeiten zur Unterstützung der Umsetzung innovativer Projekte in der Kreativwirtschaft.

Das Projekt besteht aus der Umsetzung der Forschungs- und Entwicklungsergebnisse im Unternehmen des Antragstellers zur Unterstützung der Umsetzung innovativer Projekte in der Kreativwirtschaft. Dieses Ziel wird durch den Kauf von Sachanlagen und immateriellen Vermögenswerten erreicht, die für die Entwicklung und Einführung von IT-Tools erforderlich sind – eine intelligente Plattform für die Kommunikation mit dem Kunden und Neurodesign von Werbeflächen und ausgewählten Elementen von Marketingkampagnen und Neuromarketing-Infrastruktur (eye-tracking) zusammen mit kompatibler Software.
Silver tungstate nanostructures: electrochemical synthesis and its statistical optimization

Silver tungstate (Ag2WO4) nanoparticles were synthesized by a simple electrochemical method with the aid of silver electrode and sodium tungstate as starting reagents. In this study, synthesis conditions of silver tungstate nanoparticles were optimized by Taguchi robust design. Besides, the effects of several synthesis conditions such as tungstate ion concentration, applied voltage, stirring rate, and reaction temperature on the particle size of product were investigated by SEM images. Furthermore, the significance of these factors on the diameter of silver tungstate nanoparticles was evaluated by the analysis of variance and the optimum conditions for the preparation of silver tungstate nanoparticles by electrochemical method was investigated. The resulted nanoparticles were characterized by different routes, i.e., XRD, FTIR, SEM, and PL analysis. Also, the optical band gap corresponding to the resulted Ag2WO4 nanoparticles was predicted to be 2.75 eV.
Computer simulation of electrokinetics in colloidal systems

The contribution gives a brief overview outlining how our theoretical understanding of the phenomenon of colloidal electrophoresis has improved over the decades. Particular emphasis is put on numerical calculations and computer simulation models, which have become more and more important as the level of description became more detailed and refined. Due to computational limitations, it has so far not been possible to study “perfect” models. Different complementary models have hence been developed, and their various strengths and deficiencies are briefly discussed. This is contrasted with the experimental situation, where there are still observations waiting for theoretical explanation. The contribution then outlines our recent development of a numerical method to solve the electrokinetic equations for a finite volume in three dimensions, and describes some new results that could be obtained by the approach.
Elucidation of Corrosion and Failure of Stainless Steel Tubing buried in Soil for Potable Water

Since buried pipes contact the soil directly, corrosion by the soil could be occurred. Recently, some stainless steel pipes after 8 years burial at G area were corroded and leaked. In order to elucidate highly corroded phenomena(its rate was about 0.175 mm/y) of these pipes, the investigation for corrosion environment, soil, stray current`s effect, and chemical analysis on the pipes were performed. Most of investigated sites were close to traditional water-closet and showed high moisture and thus those areas could be highly corrosive. In the investigation by two kinds of soil evaluation methods, it was revealed that the soils at G areas were highly corrosive, and moreover the contents of sulfate reducing bacteria in the soils were high. Also, open circuit potentials of many pipes showed different values and its potentials were high positive. Therefore, it was considered that corrosion of buried pipes at G area could be affected by high corrosive soil`s environment and stray current corrosion.
The unknown science: understanding the epistemology of logic through practice

We take ourselves to know certain logical claims, for example that no contradictions are true. However, we currently fail to have an adequate account of how we possess logical knowledge. Historical attempts to explain this knowledge, such as appeals to intuition, have been found to be ultimately unsatisfactory, either because they are metaphysically obscure or fail to explain logical disagreements. Yet, it is imperative that we have a complete understanding of logical knowledge. While we use logic to form beliefs in all areas of life, such as when testing scientific theories and engaging in rational debate, we now have many competing logics at our disposal to do so, all of which lead us to reasoning differently in certain situations. So, in order to ensure we reason correctly, it is paramount that we choose the right logic. Yet, in order to make these choices, we require suitable criteria to adjudicate between the logics, which can only be developed with a full understanding of what constitutes logical evidence. Without an account of logical evidence, we lack the resources to make principled and holistic decisions about the correct logic to use. EpiLog solves these problems, by: i) Advancing a theory of logical epistemology, called 'logical abductivism', which proposes that, contrary to historical consensus, we come to know logical truths similarly to how scientists know truths about the world; and, ii) Developing a set of criteria for the logical community to use to successfully adjudicate between competing logics. To support its findings, EpiLog uses a practice-based approach, inferring from logicians’ practice the underlying methods through which we gain logical knowledge. While this approach has been successful in elucidating how we gain empirical knowledge in the sciences, it has yet to be used in the study of logic. Consequently, EpiLog addresses an important gap in the literature, transferring techniques from methodological studies of the sciences to logic.
Information diffusion on networks

This two-year research project aims to analyse the simultaneous diffusion of multiple pieces of information on (social) networks; how messages may interact, how rumours diffuse in the presence of truthful information and verification, and how network structure interacts with the virality of information. Misinformation can have severe consequences, such as the debunked myth of a link between vaccinations and autism or AIDS denialism. Political examples also abound. The rise in communication through online networks is often quoted as contributing to an increased spread of rumours and misinformation. Yet, in truth the state of the art has little to say about how alternative pieces of information interact on networks, and even less why rumours might be propagated without prior verification. This project aims to build rigorous economic models which can shed light on the processes and decisions involved, thus addressing the tangible threat that the spread of misinformation poses to society. I am an experienced researcher and have worked for various years in the area of information diffusion on networks, providing me with excellent insights and methodological tools to work on this project under the supervision of Professor Sergio Currarini, a leading expert in network theory. My stay at Ca’Foscari University of Venice will allow me to establish new (international) collaborations and additional training, particularly regarding interdisciplinary tools to bring to the economic study of (mis)information diffusion. Together the training, network, and publications inherent in the development of this project will have an extremely positive impact on my career, including increased possibilities to apply for future funding calls by the EU. By forming the basis of a long-run research agenda focusing on online information diffusion the project will contribute to the EU’s Digital Market Strategy and to its international reputation as a world leading research destination.
Advance nacelle aerodynamic optimisation

ANACO will facilitate the multi-objective optimisation of short and slim nacelle design for the next generation of ultra-high bypass ratio (UHBPR) aero engines. UHBPR engine architectures offer increased propulsive efficiency through operation at reduced specific thrust, enabled by increased engine diameter. This poses special challenges, both in terms of the aerodynamic drag of the isolated nacelle and the potential for interference effects which may be imposed by a close-coupled installation on the aircraft wing.
ANACO will initially generate a population of short and slim nacelle designs which seek to minimise overall mission, rather than single design point, drag. These designs will be optimised using the latest numerical methods prior to down-select for isolated, high speed wind tunnel test enabling validation of the design tools applied. As part of this testing, experimental data quality will be improved by the enhancement of existing, and the development and application of novel, measurement techniques. The feasibility of simulating the installed wing pressure field during wind tunnel test will be assessed. The success of the optimised, down-selected geometries will also be investigated by simulation in an installed situation enabling both the overall performance improvements of the integrated wing and nacelle and the individual contributions to be understood. Finally, ANACO will deliver design rules and guidelines for future application in the design of novel, short and slim nacelles.
Alessandro RECCHIA, Symoniaca heresis. Denaro e corruzione nella Chiesa da Gregorio Magno a Graziano, Roma: Urbaniana University Press,

Alessandro RECCHIA, Symoniaca heresis.Denaro e corruzione nella Chiesa daGregorio Magno a Graziano, Roma:Urbaniana University Press,
HIGHLY REFRACTIVE, SCRATCHPROOF TIO2 COATINGS IN MONO- AND MULTILAYERS

The invention relates to coated products comprising a substrate (S) having a coating made of a single, highly refractive, and scratchproof layer (A) or having a multilayer construction, wherein layers (A) alternate with less refractive layers (B), wherein the layers (A) are characterized in that they comprise particularly finely distributed TiO2 nanoparticles.
Innovative diagnostic device for the early detection of diabetic neuropathy in diabetes patients

The objective of the innovation project is to develop and clinically validate the first diagnostic device for the early detection of diabetic neuropathy (also referred to as diabetic foot). Diabetic foot is a common complication of both type 1 and type 2 diabetes. Current methods are only able to detect diabetic foot once the patient is already experiencing loss of sensation. This can result in an increased number of amputations and costs as a result of those amputations. The disruptiveness and the market potential of the new device lie in its capacity to identify diabetic neuropathy at a very early stage. The device will fill the identified niche on the market and contribute to better clinical outcomes for the patients. The main need of the users (physicians, nurses, policy makes, and patients) is access to an efficient dependable method for early detection of diabetic neuropathy.  These needs will be met through the prototype device allowing physicians and nurses to assess the condition and determine appropriate treatment.  The Phase 1 project will develop a strategic business plan for the commercialisation of the innovative diagnostic device for the early detection of diabetic neuropathy. The project will strengthen VibroSense’s understanding of the European market in general and verify the economic viability of the clinical validation to be pursued within the Phase 2 project.  The late diagnosis of diabetic foot results in patient’s suffering and substantial health-care costs. It is estimated that approximately 1/9 of the total healthcare expenditures in Europe is spent on diabetes, with foot care being one of the more dominant costs. The project addresses this EU-wide challenge by proposing a new early-diagnostic method. The new device will build a strong case for introducing more cost-effective, personalised medicine approaches in the management of diabetic foot. The commercial output will be new competitive advantages and accelerated growth for VibroSense.
Urban adaptation to extreme heat events

The U-ADAPT! project proposes a novel approach for the dynamic measuring of urban adaptation to extreme heat. Extreme Heat Events (EHE) are the deadliest weather- and climate-related hazard in Europe. In recent years, heat waves have overwhelmed the continent, and projections show an alarming increase in EHE risk driven by natural and socioeconomic factors . Mitigation, adaptation, and transformative strategies need immediate implementation, but the rate of adaptation and depth of the transformation are in question. 

Reports stress that the progress of adaptation in European cities is patchy, uncoordinated, and of varied quality. Cities are still implementing their first adaptive measures and developing ideas for monitoring and reporting adaptation strategies. However, concrete norms or indicators for adaptation monitoring are scarce. In the research sphere, adaptation has mostly been discussed in terms of adaptive capacity, rather than implementation, which is the focus of this proposal. Despite the efforts, there is still very little consensus as to what constitutes effective and adequate adaptation, and therefore little agreement about models and indicators to measure it. 

The scientific aim of U-ADAPT! is to advance and test a theoretical integrated framework to examine the actual implementation of adaptation strategies to the risk of EHE in urban areas of the European Union (EU), in the context of Disaster Risk Reduction (DRR) and Climate Change Adaptation (CCA). The ultimate societal goal is to develop a model to assist cities in their responsibility to provide a safe and sustainable environment. The output of this research will also empower citizens to audit the commitment of their cities to EHE risk reduction and evaluate measures to reduce short- and long-term negative impacts of heat.
On the Functional Differentiation of F- and V-Type Rotary Atpases Atomic Mechanism of a Hybrid F/V Membrane Rotor

Rotary ATPases/ATP synthases have a common architecture and overall mechanism, whereby the activity of the soluble catalytic domain is coupled to the rotation of a membrane-embedded sub-complex, or c-ring, which in turn is coupled to the translocation of H+ or Na+ across the membrane. Physiologically, however, V-ATPases function only as ion pumps, while F-type enzymes function as ATP synthases. It has been proposed that this differentiation stems from the greater spacing between consecutive ion-binding sites along the circumference of V-type c-rings, relative to the F class, resulting from the different topology of the constituent c-subunits. Here, we use molecular simulation methods and bioinformatic tools to assess the atomic mechanism of the Na+-coupled ATP synthase from Acetobacterium woodii, whose unusual c-ring features one V-type c-subunit inserted along nine of the F-type, and therefore lacks one ion-binding site. Our results demonstrate that rotation of the A. woodii c-ring in either direction is not fundamentally hampered by the inserted V-type c-subunit, and explain in atomic detail why this enzyme can be driven by a transmembrane Na+-gradient and thus function as an ATP synthase. In sum, we conclude that the physiological differentiation between V- and F-type enzymes is likely to arise primarily from the availability of suitable substrates and ionic gradients in the specific environment of these enzymes, rather than from a precise structural feature.