SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Colostage : a new prognosis test for the prediction of metastasis in colorectal cancer and hepatocellular carcinoma

ColoStage is a new prognostic test, based on a novel gene expression signature, able to predict robustly the risk of disease relapse after therapeutic intervention in colorectal cancer (CRC) and potentially in hepatocellular carcinoma (HCC).  We have previously demonstrated that CRC recurrence and metastasis strictly depend on high TGF-beta signaling (Calon et al., 2012). ColoStage is a gene expression signature that reflects the TGF-beta status of the primary tumor. Therefore, the expression of the ColoStage  geneset is tightly linked to the formation of recurrent CRC after therapeutic intervention in CRC. Importantly, Colostage may also aid in the selection of patients for clinical trials who will likely benefit from newly developed drugs that target the TGF-beta signaling pathway in CRC, and possibly in other types of tumors, HCC among others, (potential use as a companion diagnostic test; i.e. Companion Dx). This proposal aims to develop the Colostage Test for competitive use in the clinical setting. This includes validation of the predictive power of the Colostage Test in an independent cohort of patient samples. Worldwide, CRC and HCC are the 3rd and 6th most commonly diagnosed cancers, with nearly 1.4 million and 800.000 new cases diagnosed in 2012 respectively. The primary treatment for CRC and HCC is surgical resection of the tumor. Prescription of chemotherapy depends on the stage of the disease at the time of diagnosis, yet current staging systems have a limited power to predict disease relapse which is usually associated with poor prognosis. Thus, an accurate method for selecting treatment based on aggressiveness and recurrence probability of the tumor such as Colostage will allow to allocate resources in a cost-effectively way and to make existing drug therapies safer and more effective
Lattice-based equation of state at finite baryon number, electric charge, and strangeness chemical potentials

We construct an equation of state for Quantum Chromodynamics (QCD) at finite temperature and chemical potentials for baryon number $B$, electric charge $Q$ and strangeness $S$. We use the Taylor expansion method, up to the fourth power for the chemical potentials. This requires the knowledge of all diagonal and non-diagonal $BQS$ correlators up to fourth order: these results recently became available from lattice QCD simulations, albeit only at a finite lattice spacing $N_t=12$. We smoothly merge these results to the Hadron Resonance Gas (HRG) model, to be able to reach temperatures as low as 30 MeV; in the high temperature regime, we impose a smooth approach to the Stefan-Boltzmann limit. We provide a parameterization for each one of these $BQS$ correlators as functions of the temperature. We then calculate pressure, energy density, entropy density, baryonic, strangeness, electric charge densities and compare the two cases of strangeness neutrality and $\mu_S=\mu_Q=0$. We also calculate the isentropic trajectories and compare them in the two cases. Our equation of state can be readily used as an input of hydrodynamical simulations of matter created at the Relativistic Heavy Ion Collider (RHIC).
Cell-Penetrating Recombinant Peptides for Potential Use in Agricultural Pest Control Applications

Several important areas of interest intersect in a class of peptides characterized by their highly cationic and partly hydrophobic structure. These molecules have been called cell-penetrating peptides (CPPs) because they possess the ability to translocate across cell membranes. This ability makes these peptides attractive candidates for delivery of therapeutic compounds, especially to the interior of cells. Compounds with characteristics similar to CPPs and that, in addition, have antimicrobial properties are being investigated as antibiotics with a reduced risk of causing resistance. These CPP-like membrane-acting antimicrobial peptides (MAMPs) are α-helical amphipathic peptides that interact with and perturb cell membranes to produce their antimicrobial effects. One source of MAMPs is spider venom. Because these compounds are toxic to insects, they also show promise for development as biological agents for control of insecticide-resistant agricultural pests. Spider venom is a potential source of novel insect-specific peptide toxins. One example is the small amphipathic α-helical peptide lycotoxin-1 (Lyt-1 or LCTX) from the wolf spider (Lycosa carolinensis). One side of the α-helix has mostly hydrophilic and the other mainly hydrophobic amino acid residues. The positive charge of the hydrophilic side interacts with negatively charged prokaryotic membranes and the hydrophobic side associates with the membrane lipid bilayer to permeabilize it. Because the surface of the exoskeleton, or cuticle, of an insect is highly hydrophobic, to repel water and dirt, it would be expected that amphipathic compounds could permeabilize it. Mutagenized lycotoxin 1 peptides were produced and expressed in yeast cultures that were fed to fall armyworm (Spodoptera frugiperda) larvae to identify the most lethal mutants. Transgenic expression of spider venom toxins such as lycotoxin-1 in plants could provide durable insect resistance.
MED ITALIA BIOMEDICA LIMITED LIABILITY COMPANY

MED-ITALIA WAS FOUNDED IN 1986 BY A GROUP OF SELECTED SPECIALISTS IN THE MEDICAL SECTOR, WITH THE AIM OF CREATING ‘INSIDE THE COMPANY’ A RANGE OF DISPOSABLE MEDICAL-SURGICAL PRODUCTS TO MEET THE SPECIFIC NEEDS OF EACH CUSTOMER, MED-ITALIA BIOMEDICAL MAKES AVAILABLE TO ITS CUSTOMERS A KNOW-HOW ACQUIRED IN YEARS OF STUDY AND DESIGN, BUT ABOVE ALL EQUIPMENT DESIGNED, TESTED, CONTROLLED AND PRODUCED IN ITALY THAT GIVE LIFE TO STANDARD PRODUCTS AND CUSTOMISED PRODUCTS TO MEET ALL THE DEMANDS AND REQUIREMENTS OF THE MEDICAL SECTOR. THE FOUNDERS OF MED-ITALIA, ALREADY PROTAGONISTS OF BIOMEDICAL TECHNOLOGICAL DEVELOPMENT, HAVE EMBARKED ON THE NEW ACTIVITY, BEING ABLE TO EASILY DISPOSE OF MATERIALS, COMPONENTS AND EXPERT STAFF. AMONG THE MAIN ACTIVITIES OF MED-ITALIA BIOMEDICA THERE IS ALSO THE MANAGEMENT IN SERVICE FOR THE SUPPLY AND MAINTENANCE OF MEDICAL-SURGICAL PRODUCTS AND DEVICES FOR THE INTERVENTIONAL RADIOLOGY DEPARTMENTS, NEU
Characteristics of Reflective Light over Red and Black Plastic Mulch, and Effect on the Quality and Yield of the Oriental Melon and Tomato

우리나라에서 주로 사용되고 있는 흑색 비닐멀칭과 신개발된 적색 비닐멀칭의 표면 반사광 특성을 분석하고 참외와 토마토에 대한 영향을 구명하여 작물생산에 대한 적용 가능성을 검토하였다. 적색 비닐멀칭의 표면에서 반사된 적색광과 초적색광의 일일 누적 강도는 흑색 비닐멀칭보다 2.6배 강했다. 적색광과 초적색광 반사광의 강도는 적색 비닐멀칭의 표면 높이 30 cm에서 가장 강하였다. 일중 태양광 강도가 강한 오후 1시 20분의 흑색 비닐멀칭의 Red/F-Red는 1.14, 적색 비닐멀칭은 0.93, 태양광은 1.16으로 적색 비닐멀칭이 흑색 비닐멀칭보다 초적색광 강도가 높았다. 적색 비닐멀칭의 Red/F-Red는 표면 높이 30 cm에서 가장 낮았으며 표면높이가 높아질수록 초적색광 강도가 감소하여 Red/F-Red는 증가하였다. 적색 비닐멀칭 반사광의 Red/F-Red는 정오부터 오후 4시경까지는 흑색 비닐멀칭보다 낮게 경과하였다. 흑색 비닐멀칭 처리구보다 적색 비닐멀칭 처리구의 참외 과실의 무게가 증가하여 수량이 증가하였고 당도가 높았다. 토마토의 과실 무게와 당도도 적색 비닐멀칭 처리가 흑색 비닐멀칭 처리구보다 높았다. 지중온도는 적색 비닐멀칭 처리가 흑색 비닐멀칭 처리보다 다소 낮은 경향이었다. 따라서 적색 비닐멀칭으로 토양을 피복하면 작물생산에 적색광과 초적색광을 더 많이 이용할 수 있을 것으로 판단된다. BACKGROUND: Plastic mulches widely used in raised-bed culture mainly to conserve water, control weeds and raise soil temperature. The most widely used plastic mulch colour is black. Reflective red and far-red light can affect on growth and yield of various vegetable crops. Objectives of this study were to investigate the characteristics of reflective light of black and red plastic mulches, and to evaluate the reflective red and far-red light on the quality characteristics and yield of the Oriental melon (Cucumis. Melo L.) and tomato (Lycopersicon esculentum L.). METHODS AND RESULTS: Oriental melon and tomato were cultivated over the reflective red and black plastic mulches in plastic house. Reflected red and far-red light over the red plastic mulch were 2.6 times higher than those of black plastic mulch. Red to F-Red ratio of black plastic mulch, red plastic mulch and sunlight were 1.14, 0.93 and 1.16 respectively. Intensity of reflected red and far-red light over red plastic mulch were highest at surface height of 30 cm. The higher the height of the surface decrease the intensity of far-red light. Accordingly, Red to F-Red ratio were increased. Reflective red plastic mulch increased the weight of fruit and content of sugar in Oriental melon and tomato. CONCLUSION(s): Yield of Oriental melon over reflective red plastic mulch was higher than that of black plastic mulch. These results suggested that reflected red and far-red light over the red plastic mulch affected allocation of photosynthate in growing Oriental melon.
Cervical cancer detection platform based on novel laser processing

About 10% of all cancers diagnosed in women worldwide, are cancers of the cervix, the organ that connects the uterus and the vagina. Alone in the European Union over 16,000 deaths are reported annually due to cervical cancer effecting women mainly between the ages of 25 and 50.
Within the scope of this fellowship, hosted by Dublin City University (Ireland) in collaboration with Arrows Biomedical GMBH (Germany), a highly sensitive platform to detect Human Papillomavirus (HPV), causative agent of about 99.7% of cervical cancer, will be developed. The proposed diagnostic platform will be based on a laser textured biopolymer as device substrate, functionalized with nanoparticles produced via the Pulsed Laser Ablation in Liquid (PLAL) technique. This on-chip immunoassay will allow rapid detection of the HPV. The novelty of this project lies in the high-quality bio-nanostructures as nano-labels via PLAL designed for ultrasensitive detection of HPV. 
Two major aspects of this project are: (1) the development of complex nano-labels specifically targeting high risk HPV; and (2) improvement in the performance of the developed assay  increasing their sensitivity and specificity, relative to current start of the art. 
Ultrapure HPV-specific nano-labels will be prepared using pulsed laser ablation in liquid, a green synthesis route independent of any chemical processing. The proposed technique is advantageous due to the enhanced surface activity of laser-generated nanoparticles, which will reduce the amount of sample molecules needed for the successful detection by improving the limit of detection and overall detection time. This project aims at making substantial contribution to the advancement of cancer immunosensing based on a novel on-chip immunoassay design for medical applications. Through this project, the applicant aims to develop intellectual property related to the manufacturing of biomedical devices via laser processed surfaces.
Improving regional policies to reduce light pollution and protect and valorise dark night skies

A satellite image of night-time Europe shows a continent that is covered in light. Over 85% of the EU territory is subject to some degree of artificial illumination. This increasing loss of natural darkness has a negative impact on biodiversity and ecosystems and on the quality of nature and the environment. Regions across Europe must intensify their policy efforts to reduce light pollution and protect areas with naturally dark night skies to help preserve their nature and vulnerable landscapes and prevent biodiversity loss. 
At the same time there are opportunities for sustainable economic development linked to the protection of dark skies. Several EU regions already demonstrate this by creating areas where the dark sky has a protected status and successfully positioning this as an asset to develop new eco-tourism services. 

In the Night Light project regional authorities from The Netherlands, Hungary, Spain, Luxemburg, Denmark, Slovenia and Italy join forces to improve their regional policies for the prevention of light pollution, preservation of dark skies and the sustainable exploitation of dark sky places. The project will introduce packages of regional policy measures for each of the partner regions that will result in a lasting reduction of light pollution, the designation of nature areas where dark skies are protected and the introduction of new services and facilities to attract eco-tourism to these dark sky areas.
Replication Data for: Efeitos da pandemia sobre o abandono escolar no Espírito Santo

Script para o software R e dataset
Manufacturing of tumour-reactive natural killer cells

This project will provide future-oriented translational research training designed to bridge the gap between basic research and applied development of new cell-based therapeutic products by the biotech industry and their clinical use for incurable diseases. This will be done on the example of activated/genetically manipulated natural killer (NK) cells, which are classified as Advanced Therapy Medicinal Products (""ATMPs""), and their use in treatment of cancer refractory to classical therapies. For this we combine experts in NK cell biology supported by bioinformatics, clinical groups pioneering NK cell therapies and biotech companies with NK cell-based portfolios. A student exchange will ensure training in basic, clinical and private sectors. Network-wide training modules organized in summer/winter schools include immunotechnology, business management and intellectual property rights. This will train competences important to translate research findings to personalized medicine.
In research we build on information from clinical trials of NK cell-based therapies. We will improve anti-tumor reactivity of NK cells including selection of NK subsets and modulation of NK receptor/ligand interactions. First, this will comprise i) improved donor/recipient combination and NK subsets and ii) modification of NK cells by chimeric antigen receptors (""CAR"") and bispecifc antibody reagents to cross-link NK cells to tumor targets. Second, it will fortify NK cell reactivity by i) blocking ligand interactions of inhibitory receptors (""checkpoint inhibitors"") and ii) defining unknown ligands of activating NK receptors on tumor cells. Third, procedures and NK products in their best combination will be developed by i) evaluation in humanized mouse models, ii) building a GMP-compliant manufacturing process and iii) design of a clinical trial protocol. The project should provide for manufacturing of NK cell-based therapeutic products and their evaluation in clinical trials.
Solid state detectors for dosimetry in the BNCT beam of the LVR-15 research reactor

Abstract Dosimetry measurements have been carried out at the epithermal neutron beam of LVR-15 reactor (Řež) moderated by a polyethylene disk placed through the collimator exit. The spatial distributions of thermal neutron fluence rate and of gamma and fast neutron dose rates have been attained. The contributions to the dose of the radiation field components have been assessed with Fricke-gel-layers, by pixel-to-pixel elaboration of the light transmittance images of samples having different isotopic composition and with thermoluminescence detectors, by analysing the shape of the glow curve. An analogous experiment has been carried out at the thermal column HK1 of the same LVR-15 reactor, aimed at neutronography research. Good consistency of all results was obtained.
Le sans-abrisme au féminin. Quand les haltes pour femmes interrogent les dispositifs d’urgence sociale

Cet article présente les résultats d’une enquête de terrain ethnographique réalisée entre novembre 2018 et octobre 2019 dans des haltes pour femmes sans-abri à Paris. Il rend compte des difficultés à définir et accueillir un public que les acteur·trice·s institutionnel·le·s et associatifs n’avaient pas anticipé. Loin d’accueillir seulement des femmes isolées, très désocialisées, en refus d’hébergement ou éloignées des dispositifs d’hébergement existants, les haltes rendent visibles des femmes en situation de grande vulnérabilité, présentant des caractéristiques sociales très différentes de celles des hommes accueillis dans des structures d’urgence comparables. Ce faisant, ces haltes questionnent le principe de la simple mise à l’abri d’urgence au regard des besoins d’accompagnement spécifiques de ces femmes longtemps restées invisibles dans les représentations sociales, les politiques publiques et les travaux scientifiques.
Establishing services enhancing the innovation management capacity of smes by the enterprise europe network in north rhine-westphalia, germany, in 2017 -2018

This project is to be understood as an integrated component of the Enterprise Europe Network activities in North Rhine-Westphalia for the years 2017 -2018. For this period ZENIT will undertake - as part of the future NRW.Europa project - the additional task of ""Enhancing the innovation manangement capacities of SMEs"".

This task consists of two service packages pre-defined by the European Commission / EASME and foreseen for a limited number of enterprises:
1. Beneficiaries of the SME Instrument of Horizon 2020 (Key Account Management, KAM)
2. SMEs with significant innovation activities and a high potential for internationalization (promising SMEs with gaps in the innovation management systems).

Whereas the first action is reserved for beneficiaries of the new SME instrument with a dedicated coaching scheme, the second is targeted at highly promising innovative enterprises, which will be assisted with a two-step support scheme:
1. Recording, analysis and evaluation of the individual status quo and of fundamental requirements and possibilities as well as of the threats and risks of the participating enterprises (analysis of needs and gaps, SWOT analysis).
2. Development and implementation of individual concepts, measures, and activities (action and / or coaching plan).

ZENIT considers a combination of self-assessment and interview with a senior consultant to be the most effective solution for the first stage and to fulfil the requirements of CEN / TS 16555-1 (innovation management system). The ZENIT Self Assessment tool will be used as priority, other tools like IMP³rove, Steinbeis or N-Bank will be introduced to meet specific needs of SMEs.
CYCLODEXTRIN SULFONATES, GUEST INCLUSION COMPLEXES, METHODS OF MAKING THE SAME AND RELATED MATERIALS

This invention relates to new cyclodextrin derivatives, processes for producing these cyclodextrin derivatives, and inclusion complexes comprised of the new cyclodextrin derivatives and guest molecules, as well as methods of making such materials and methods of using the same.
In vitro cell response to Co-containing 1393 bioactive glass

Cobalt ions are known to stimulate angiogenesis via inducing hypoxic conditions and hence are interesting agents to be used in conjunction with bioactive glasses (BGs) in bone tissue engineering approaches. In this work we investigated in vitro cell biocompatibility of Co releasing 1393 BG composition (in wt.%: 53SiO2, 6Na2O, 12K2O, 5MgO, 20CaO, and 4P2O5) derived scaffolds with osteoblast-like cells (MG-63) and human dermal microvascular endothelial cells (hDMECs). Cell viability, cell number and cell morphology of osteoblast-like cells in contact with particulate glass and 3D scaffolds were assessed showing good biocompatibility of 1393 reference material and with 1 wt.% CoO addition whereby 5 wt.% of CoO in the glass showed cytotoxicity. Furthermore for 1393 with 1 wt.% of CoO increased mitochondrial activity was measured. Similar observations were made with hDMECs: while 1393 and 1393 with 1 wt.% CoO were biocompatible and the endothelial phenotype was retained, 5 wt.% CoO containing BG showed cytotoxic effects after 1 week of cell culture. In conclusion, 1 wt.% Co containing BG was biocompatible with osteoblast like cells and endothelial cells and showed slightly stimulating effects on osteoblast-like cells whereas the addition of 5 wt.% CoO seems to exceed the vital therapeutic ranges of Co ions being released in physiological fluids.
Efficient Visible-Light-Driven Photocatalytic Degradation with Bi<sub>2</sub>O<sub>3</sub> Coupling Silica Doped TiO<sub>2</sub>

A new TiO2-based visible light photocatalyst (Bi2O3/Si–TiO2) was synthesized by both Bi2O3 coupling and Si doping via a two-step method. The structural, morphological, light absorption, and photocatalytic properties of as-prepared samples were studied using various spectroscopic and analytical techniques. The results showed that Bi2O3/Si–TiO2 catalysts held an anatase phase and possessed high thermal stability. The doped Si was woven into the lattice of TiO2, and its content had a significant effect on the surface area and the crystal size of Bi2O3/Si–TiO2. The introduced Bi species mainly existed as oxides on the surface of TiO2 particles, and the Bi2O3 photosensitization extended the light absorption into the visible region. Bi2O3 coupling also favored the separation and transfer of photoinduced charge carriers to inhibit their recombination and Si doping enlarged the surface area of photocatalysts. Compared to bare TiO2, Bi2O3/TiO2, and Si–TiO2, Bi2O3/Si–TiO2 samples showed better activities for the de...
Europe'S transformation: where people matter

The project will organise the presidency event (conference) “Europe’s Transfomation: Where People Matter” in Vienna, Austria, November 2018.    It encompasses the operational and strategic work required to host this event, including Innovation and Content Management (e.g. collaboration with stakeholders to jointly design the conference programme); the Conference Logistics (e.g. organising a venue and the registration process); and Dissemination and Exploitation of the conference outcomes (e.g. setting up a conference website and collaborating with media).    With regard to the wider context of the UN's Sustainable Development Goals, the overall aim of the conference is to foster an improved synergy between pertinent initiatives launched by the Commission and by the Member States, to the benefit of the overall coherence of actions within the field of research and innovation in the areas covered by Societal Challenge 5.
Pensar la ciudad haciendo ensayo: la antropología social de Manuel Delgado

El presente artículo se centra en algunos ensayos realizados por M. Delgado en torno al espacio urbano. Desde la antropología social, su trabajo escruta con mirada crítica el resultado de la planificación urbana de la que ha sido objeto Barcelona, para concluir que numerosas ciudades contemporáneas se rigen por los mismos esquemas de acción. En defensa de la diversidad, indaga entre los lenguajes al uso mediante un minucioso análisis de los significados que encierran. Apoyándose en una escritura que se balancea entre el rigor científico, una subjetividad a flor de piel, múltiples lecturas y un perfecto dominio de las figuras retóricas, elabora una poética en la que el factor social es protagonista. Como actor social, acude a las posibilidades del ensayo, tan prolijo para des-velar opacidades, colaborando en una sociopoética urbana que se esfuerza, ofreciendo claras muestras de su capacidad creativa, por recuperar el espacio público y el ágora prometida por las democracias neoliberales.
Laboratory Model Test on Foundation Reinforcement by Locating Lime-Soil Pileat both Side of Strip Footing

Using similarity theory as guidance ,the paper designs the laboratory model test on foundation reinforcement by locating lime-soil pile at both side of strip footing, and researches foundation bearing capacity, p-s curve, the magnitude and distribution discipline of the foundation stress before and after reinforcement, and analyzes the load-bearing mechanism, strengthening mechanism and reinforcement effect of the strengthening technology. The results show that the lime-soil pile can effectively improve the foundation bearing capacity, and reduce the amount of ground settlement; under the role of the lime-soil pile, the stress spread lesser to the outside of pile in the ground, and causes the foundation stress to the deeper place.