SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Skin tissue integrity under shear

The mechanical, chemical and biological properties of human skin may be challenged when in contact with another surface e.g. immobilized persons supported on a bed or in a wheelchair, amputees wearing a prosthesis, and individuals with orthoses or functional medical devices attached to the skin. This can result pressure ulcers, particularly in the elderly and those with comorbidities such as diabetes. Skin condition is also critical during interactions with personal care products such as creams, shavers, grooming devices, therapeutic lamps or massage equipment, which can result in various forms of irritation. The main scientific aim of STINTS is to understand the complex biomechanical and biochemical pathways leading to loss of skin integrity, following the exposure of the skin to prolonged pressure and shear forces that ultimately result in damage at the cellular level. The objective is to reduce the huge societal and financial costs of pressure ulcers by improving (a) the design of more effective preventative aids (mattresses, shoe insoles, incontinence products etc.), (b) early stage diagnosis (non-invasive biomarkers and sensors, and smart materials) and (c) ultrasound therapy. The new understanding of skin behaviour will also be exploited by application to personal care products (razors that cause minimal skin irritation and skin creams with more efficacious skin hydration and barrier properties). These objectives will be achieved by the deployment of experts in multi-scale computer simulation, experimental cellular and tissue biomechanics, biophysical monitoring, sensor design, medical devices and materials, and clinical studies. STINTS will create an ambitious environment of supradisciplinary inter-sectoral research training for early stage researchers that combines the needs for the creative skills of academic and industrial researchers, the entrepreneurial drive of the private sector and clinical innovation.
HOLE TRANSPORT COMPOSITIONS AND RELATED DEVICES AND METHODS (II)

A composition comprising: at least one compound comprising a hole transporting core, wherein the core is covalently bonded to a first arylamine group and also covalently bonded to a second arylamine group different from the first, and wherein the compound is covalently bonded to at least one intractability group, wherein the intractability group is covalently bonded to the hole transporting core, the first arylamine group, the second arylamine group, or a combination thereof, and wherein the compound has a molecular weight of about 5,000 g/mole or less. Blended mixtures of arylamine compounds, including fluorene core compounds, can provide good film formation and stability when coated onto hole injection layers. Solution processing of OLEDs is a particularly important application.
Bespoke acoustic emission system for real-time ship hull monitoring for all weather conditions

The European ship repair and maintenance industry suffers from outdated techniques, high labour costs and depressed prices: ship repair operations are inefficient because currently it is impossible to quantify accurately the extent of work required before the ship is in dock.  ETS Sistemi has developed ShipHullSHM solution (currently at TRL 6) to tackle the above issues. Our aim is to commercialise an innovative ship hull Structural Health Monitoring (SHM) system for use in noise-dominated dynamic and critical environment to improve safety and profitability of the European ship industry. The ShipHullSHM system seeks to implement continuous monitoring of ships hulls to localise incipient failures, thus greatly increasing the efficiency of the ship repair process, guiding shipyard operations by repair and maintenance providers and supporting vessel management by ship owner. ShipHullSHM will utilise the acoustic emission into noise-dominated dynamic, critical environments hosting structures requiring continuous SHM. The system comprises a networked array of passive acoustic emission sensors linked through fibre optics to an advanced signal processing unit that analyses and identifies initiated damage and incipient crack propagation in real-time. ShipHullSHM has the capability to save the EU and other countries a total of €6Bn from lost revenue, ship replacements and insurance compensation, €1.2Bn p.a.net savings for the ship operators from a ShipHullSHM installation. Due to the foreseen market opportunity for ShipHullSHM, we are interested to conduct a feasibility study for our product through SMEi Phase 1 project. In this feasibility study, we will produce a comprehensive commercialisation and business plan using the information that we gathered on market research, competitors’ analysis and profiling, SWOT and PESTLE analyses, patent reviews, certification requirements, distribution channels, pricing strategy, etc.
Revised Version of the Automobile Level-of-Service Methodology for Urban Streets in the Highway Capacity Manual 2010

The Highway Capacity Manual 2010 (HCM 2010) contains a significantly revised automobile analysis and level-of-service (LOS) methodology for arterials. This study compared the arterial LOS results of the HCM 2000 and HCM 2010 methodologies for an experimental set of arterial segments and analyzed the effects of the revised methodology. In addition, existing Florida field data sets were also analyzed with arterial segments obtained from Gainesville, Tallahassee, and Tampa, all in Florida, as well as data received from the Florida Department of Transportation Districts 2 and 3. The HCM 2010 results showed that for shorter, lower-speed arterial segments [such as in central business districts (CBDs)] it was not possible to obtain LOS Ratings A or B. Therefore, many CBD arterials that had good LOS values under the HCM 2000 methodology would now have moderate to poor LOS values. Consequently, the research team tested several revisions of the HCM 2010 methodology to find an approach that would not be as punitive to arterials with shorter segment lengths and that would provide a good balance of LOS values across a range of segment lengths, posted speeds, and traffic demands. Suggested revisions to the HCM 2010 methodology that allowed this objective to be achieved consisted of the following: the use of two classes instead of one (on the basis of the posted speed); the use of the average travel speed as the service measure instead of the ratio of the average travel speed to the base free-flow speed; and the setting of the free-flow speed to equal the posted speed plus 5 mph, instead of using the free-flow speed computations in the HCM 2010 methodology.
New epitopes and function of anti-M3 muscarinic acetylcholine receptor antibodies in patients with Sjögren's syndrome

M3 muscarinic acetylcholine receptor (M3R) plays a crucial role in the secretion of saliva from salivary glands. It is reported that some patients with Sjögren's syndrome (SS) carried inhibitory autoantibodies against M3R. The purpose of this study is to clarify the epitopes and function of anti-M3R antibodies in SS. We synthesized peptides encoding the extracellular domains of human-M3R including the N-terminal region and the first, second and third extracellular loops. Antibodies against these regions were examined by enzyme-linked immunosorbent assay in sera from 42 SS and 42 healthy controls. For functional analysis, human salivary gland (HSG) cells were preincubated with immunoglobulin G (IgG) separated from sera of anti-M3R antibody-positive SS, -negative SS and controls for 12 h. After loading with Fluo-3, HSG cells were stimulated with cevimeline hydrochloride, and intracellular Ca(2+) concentrations [(Ca(2+) )i] were measured. Antibodies to the N-terminal, first, second and third loops were detected in 42·9% (18 of 42), 47·6% (20 of 42), 54·8% (23 of 42) and 45·2% (19 of 42) of SS, while in 4·8% (two of 42), 7·1% (three of 42), 2·4% (one of 42) and 2·4% (one of 42) of controls, respectively. Antibodies to the second loop positive SS-IgG inhibited the increase of (Ca(2+) )i induced by cevimeline hydrochloride. Antibodies to the N-terminal positive SS-IgG and antibodies to the first loop positive SS-IgG enhanced it, while antibodies to the third loop positive SS-IgG showed no effect on (Ca(2+) )i as well as anti-M3R antibody-negative SS-IgG. Our results indicated the presence of several B cell epitopes on M3R in SS. The influence of anti-M3R antibodies on salivary secretion might differ based on these epitopes.
(14508.17092020.172000278) PG

ASCOT SRL? A COMPANY? ESTABLISHED IN 1994 THAT HAS ALWAYS CARRIED OUT ACTIVITIES? COMMERCIAL IN THE METAL PARTS SECTOR FASHION AND PELLETTERIE.FROM 2020, THANKS TO THE EXPERIENCE GAINED IN RECENT YEARS BY THE ADMINISTRATOR AS WELL AS? PARTNER OF THE COMPANY? THE COMPANY’S INTENTION? CONVERTING PROPIA ACTIVITY? IN THE FIELD OF ELECTROPLATING METAL PARTS, FOR WHICH THE MARKET IS SEEN GOOD POSSIBILITIES? TO ACHIEVE POSITIVE ECONOMIC RESULTS.THE INVESTMENTS NEEDED TO START THE ACTIVITY? DO THEY CONSIST OF THE PURCHASE OF PLANTS AND EQUIPMENT AND IN THE INSTALLATION AND COMMISSIONING OF THE SAME FOR A TOTAL AMOUNT OF ABOUT EUR 853 THOUSAND, INCLUDING MASONRY AND PLUMBING WORKS AND AN INITIAL INVESTMENT IN PRECIOUS METALS OF ABOUT EUR 148 THOUSAND.IN RESPECT OF EMPLOYEES? DO YOU PLAN TO HIRE AN EMPLOYEE AT THE TIME OF THE START OF THE BUSINESS? AND ONE OR TWO APPRENTICES FROM THE FOLLOWING YEAR (2021)
SPRAY DEVICE AND DOSAGE CARTRIDGE

One aspect of the invention relates to a delivery device for spraying a medicament product as a series of sprays. The delivery device includes a spray device and a cartridge. The spray device includes a pump and the cartridge includes a vial and a plunger. The vial bounds in part a chamber in which is located a piston. The piston divides the chamber of the vial into a first part in which a medicament product is located and a second part which is open to atmosphere. When the spray device is connected to the vial, a dosage flow path is established between the first part of the chamber and an outlet of the pump. The plunger is arranged to be received in the vial and is operable by a user so that actuation of the plunger primes the pump by forcing air within the dosage flow path out of the outlet. That air is replaced with medicament product from the first part of the chamber. Thereafter, when the pump is operated, the piston is drawn along the chamber forcing medicament to move along the dosage flow path and out of the outlet of the pump. Another aspect of the invention relates to a tamper evident delivery device. A still further aspect of the invention relates to a tamper evident cartridge.
Peacebuilding in Timor-Leste: Finding a Way between External Intervention and Local Dynamics

This article highlights the importance of interaction between peace missions and local dynamics, drawing on Tsing's work on frictions. It is centred on the United Nations (UN) peace intervention in Timor-Leste, discussing different examples of frictions, which have the potential to undermine or empower the peacebuilding efforts underway. The analysis stresses the unpredictable effects of applying the UN liberal peace model. It is argued that processes of friction, often consisting of an incremental build-up of intermediate results shape and form the (un)sustainability of any peacebuilding process initiated by an external intervention and, consequently, should be identified and analysed in order to enhance or minimize their positive/negative contribution towards building peace.
Study of the tryptophan–terbium FRET pair coupled to silver nanoprisms for biosensing applications

Plasmonic coupling between fluorophores and metal surfaces has become a focal point of optical research during the last two decades, however, the interactions of FRET couples with metal surfaces remain relatively unexplored. In this study, interactions of the tryptophan-Tb(3+) FRET pair with silver nanoprisms for potential biosensor development have been investigated. For this purpose an engineered lanthanide binding peptide (LBTtrp) containing tryptophan as the sensitizer for bound lanthanide ions (Tb(3+)) as well as a trypsin cleavage site was synthesized. The modified LBTtrp peptide contained two N-terminal cysteine residues to provide a stronger coupling to the silver nanoprisms (~6 nm high, ~50 nm wide). This study investigated the interaction between tryptophan, chelated Tb(3+) ions, and silver nanoprisms in solution using fluorescence and transient absorption spectroscopy. We have found that Tb(3+) luminescence decreases upon binding of the LBTtrp-Tb(3+) to silver nanoprisms and increases upon trypsin cleavage. The transient absorption spectroscopy measurements showed a significant decrease in the lifetime of the excited singlet state of tryptophan upon Tb(3+) chelation, while coupling to the silver nanoprisms did not show a significant effect on tryptophan. The results obtained in this work demonstrate a first proof of concept for a new sensitive optical biosensor in solution.
The necklace of the Pleiades : studies in Persian Literature Presented to Heshmat Moayyad on his 80th Birthday : 24 essays on Persian literature, culture and religion

The Necklace of the Pleiades is a volume on Persian literature, culture and religion by Persian scholars from around the world. This book reflects the state of the field of Persian literary studies and will be of substantial interest not only to scholars of Iranian culture, history and religions, but of Middle Eastern and South Asian studies, as well. The topics of the 24 essays range from the Persian Alexander romance, to Ferdowsi’s Shahnama and other epics, the poetics and imagery of the ghazal and the qasida, Mughal court poetry, Sufism, Ismaili history, Baha’i literature, Iranian linguistics, the modern writer Sadeq Hedayat, and the reception of Salman Rushdie’s novel in Persian translation.
Explaining the Discrepancy of Antisemitic Acts and Attitudes in 21st Century France

This paper assesses antisemitism in France and provides an overview of antisemitic acts and attitudes presented in survey results over the past decades. A clear rise in both the number of antisemitic incidents and the level of violence can be traced since 2000. Attitude surveys, on the other hand, do not show such a clear rise of antisemitic attitudes. There are two plausible explanations for this seeming discrepancy. The first is that antisemitic stereotypes may have changed over the years and that therefore no comparable survey data exist. Anti-Zionist forms of antisemitism, which are rarely surveyed, are likely to have become more widespread, whereas older biases contesting the Frenchness of French Jews have waned. The second is that perpetrators of antisemitic acts are a small minority of people who hardly influence the results of representative surveys. Particularly high levels of classic antisemitic attitudes can be found among Muslims and among sympathizers of the far right, and, to a lesser extent among the far left. Antisemitism seems to have radicalized within small groups of French society, including the use of extreme violence against Jews. Fringe groups of radicalized French Islamists pose an additional security threat to French Jews in particular and to society in general.
Conserved patterns of integrated developmental plasticity in a group of polyphenic tropical butterflies

Developmental plasticity is thought to have profound macro-evolutionary effects, for example, by increasing the probability of establishment in new environments and subsequent divergence into independently evolving lineages. In contrast to plasticity optimized for individual traits, phenotypic integration, which enables a concerted response of plastic traits to environmental variability, may affect the rate of local adaptation by constraining independent responses of traits to selection. Using a comparative framework, this study explores the evolution of reaction norms for a variety of life history and morphological traits across five related species of mycalesine butterflies from the Old World tropics.Our data indicate that an integrated response of a suite of key traits is shared amongst these species. Interestingly, the traits that make up the functional suite are all known to be regulated by ecdysteroid signalling in Bicyclus anynana, one of the species included in this study, suggesting the same underlying hormonal regulator may be conserved within this group of polyphenic butterflies. We also detect developmental thresholds for the expression of alternative morphs.The phenotypic plasticity of a broad suite of morphological and life history traits is integrated and shared among species from three geographically independent lineages of mycalesine butterflies, despite considerable periods of independent evolution and exposure to disparate environments. At the same time, we have detected examples of evolutionary change where independent traits show different patterns of reaction norms. We argue that the expression of more robust phenotypes may occur by shifting developmental thresholds beyond the boundaries of the typical environmental variation.
“El Mar nos Une”: imaginarios geopolíticos y frontera marítima en el diferendo Bolivia-Chile

Este artículo propone un acercamiento a los imaginarios geopolíticos surgidos en el contexto de la demanda jurídica presentada por Bolivia en la Corte Internacional de La Haya en 2013, resuelta en 2018. Desde un análisis crítico de discurso, este trabajo intentará mostrar como el tiempo legal, el tiempo de la demanda, abre un horizonte de diferentes planos de producción de representaciones en torno al mar y su recuperación como referente para la política exterior boliviana. En términos de materiales, se trabajará con textos y registros visuales publicados tanto por instituciones oficiales (ministerio de Justicia y Transparencia Institucional, Procuraduría General del Estado, etc.), como por actores no institucionales (artistas), así como con prácticas espaciales (el “banderazo”) con el propósito de mostrar la amplia y diversa imaginación geopolítica ligada a la demanda de un “Mar para Bolivia”.
Blueberry Polyphenols and Neuroprotection

Abstract Several studies have highlighted the health-promoting effects of antioxidants contained in fruit and vegetables. Blueberries are palatable fruits with one of the highest antioxidant contents to be found. Oxidative stress plays a key role in aging and neurodegeneration. In the last 15 years, the effects of blueberries’ polyphenolic compounds in neurons and their influence on brain performance have been explored. Blueberry polyphenols have been shown to enhance neuroprotection through molecular mechanisms involving, beyond a radical scavenging activity, the counteraction of β-amyloid toxicity, neuroinflammation, and excitotoxicity. They normalize sensitivity to neurotransmitters and promote synaptic plasticity, cell growth, and survival and also act by regulation of gene expression. These mechanisms can slow down the process of aging in young animals and reverse age-related decline in aged animals. Cognitive performance in humans is also improved. This represents the basis for new nutraceuticals in the prevention of brain aging and the therapy of neurologic diseases.
Creative agency and religious minorities: ‘hidden galleries’ in the secret police archives in 20th century central and eastern europe

This project concerns the creative agency of religious minorities in the transformation of Central and Eastern Europe societies in the 20th century. It constitutes the first comparative research on the secret police archives in the region from the perspective of the history and anthropology of religion and offers a radical perspectival shift on the value and uses of the secret police archives away from questions of justice and truth to questions of creative agency and cultural patrimony. Interdisciplinary in nature it combines archival, anthropological and cultural studies approaches to provide a re-examination and re-contextualization of the holdings of secret police archives in three states; Romania, Moldova and Hungary. The secret police archives, in addition to containing millions of files on individuals monitored by the state, also constitute a hidden repository of confiscated religious art and publications of religious minorities that were persecuted in the 20th century under fascism and communism. The investigation of these materials will be complemented by ethnographic research and the impact of the research will be extended through a public exhibition of previously hidden materials. The project has three principal stages: 1) copy/retrieve and catalogue examples of this creative material from the archives; 2) engage in ethnographic research with the communities that produced this material in order to explore the meaning and power of these artistic creations at the time of their production and in the context of post-socialism; 3) curate and stage a touring exhibition that re-presents the narratives and experiences of religious groups through their own artistic creations in order to conduct research in real time on questions of religious pluralism and intolerance in contemporary society. Through these three steps, this project will shed fresh light on the role that minority religious groups played in challenging the hegemonic order and in extending pluralism.
Preservation of semi-liquid Aloe gel: total phenolic and emodin content

Semi liquid Aloe gel (LBSC) was preserved using sodium chloride (1, 2 and 3%) and sugar (10, 20 and 30%) for 7 weeks at 4oC. Physical observations (color, odor and gas) and chemical analysis (total phenolic and emodin) were performed every week during preservation. Changing color was observed at the fourth week and until the seventh week. The total phenolic content decreased by 23.2, 12.9 and 19.0% in LBSC with 1, 2 and 3% salt respectively. The total phenolic content in LBSC with 10, 20 and 30% sugar decreased by 64.0, 53.8 and 30.4% respectively. The emodin content decreased by 60.7% for control (LBSC alone), but in LBSC with 1, 2 and 3% salt it was decreased by 26.2, 19.2 and 50.8% respectively. The emodin content in LBSC with 10, 20 and 30% sugar decreased by 70.5, 67.4 dan 82.4% respectively. Emodin was more unstable than total phenolic. Preservation using sugar was not preserve the availability of emodin, while salt could inhibit the decrease of emodin concentration in LBSC. Preservation of LBSC with 2% table salt gave the lowest decrease of emodin and total phenolic contents Key words: Aloe vera , fenol, emodin, preservation