SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
The role of extra centrosomes on the tumour microenvironment

The centrosome, an organelle important for cell division, is frequently amplified in cancer, including breast cancer. In this fellowship I propose to investigate how cells with centrosome amplification change the tumour microenvironment (TME) to promote breast cancer development. Recent work has shown that having extra centrosomes drive tumour growth in vivo, indicating that centrosome amplification is not a bystander of cancer, but promotes tumorigenesis. Consistent with a direct role in cancer, we previously demonstrated that centrosome amplification leads to chromosome instability and cell invasion. In addition to the cell autonomous effects of centrosome amplification, our lab has recently found that cells containing extra centrosomes also have non-cell autonomous effects via secretion of proteins that induce a paracrine invasive phenotype in mammary organoids. We also found that cells with pancreatic cancer cells with extra centrosomes secrete small extracellular vesicles (sEVs) that induce activation of the fibroblast-like pancreatic stellate cells (PSCs). Moreover, using xenograft immunocompetent mouse models, we found that induction of centrosome amplification in SUM225 human breast cancer cells leads to a strong innate immune infiltration (e.g. macrophages and neutrophils) surrounding the tumours. Guided by our preliminary data we hypothesise that altered secretion in cells with centrosome amplification changes the TME. Currently there is no published link between centrosome amplification and TME. I aim to characterise TME changes induced by centrosome amplification in vivo and to identify factors secreted by cells with extra centrosomes responsible for such changes. This work will be the first in-depth characterisation of TME in tumours containing extra centrosomes. Importantly, this project will start an exciting and novel research avenue bridging the centrosome and the TME fields.
The temperature dependence of the acute toxicity of heavy metals (cadmium, copper and mercury) to a freshwater pond snail, Lymnae aluteola L.

Abstract Responses of a freshwater pulmonate snail Lymnae aluteola L. to copper, cadmium and mercury were observed at four temperatures in the range of 15.0 C to 30.0 C. Acute static bioassays were carried out at 15.0 C, 20.0 C, 25.0 C and 30.0 C to determine the percent mortality and median lethal concentrations (LC50) and their 95 percent confidence limits. The acute toxicity of mercury, copper and mercury increased with the increase of temperature from 15Cto 30C. The 96 h LC50 values and percent mortality indicate that metals at 15Cwas least toxic while at 30C it was highly toxic.
HEATING SYSTEM FOR HEATING FLUID IN A TANK

A heating system for heating fluid in a tank includes a heating device for heating and pumping water to a tank heater via a hose. The tank heater has a pump connected to a heat exchanger. The heat exchanger has a plurality of tubes disposed in a housing that receive fluid from the tank. The heating device pumps hot water through the heat exchanger to transfer heat to fluid in the tubes and the back to the heating device. The pump circulates fluid within the heat exchanger.
Inhibitory receptor expression on neonatal immune cells

Neonates are born with quantitative and qualitative defects in both adaptive and innate immune responses. The immune system is regulated by several mechanisms, including the signalling of inhibitory receptors. Increased expression of inhibitory receptors may result in a higher threshold for activation and suppressed function of neonatal cells. The aim of this study was to determine whether the expression of seven inhibitory receptors is increased on neonatal immune cells compared to adult immune cells. In a healthy birth cohort, we examined the expression of seven inhibitory immune receptors on neonatal neutrophils, monocytes, natural killer (NK) cells, CD4(+) and CD8(+)T cells. The expression of leucocyte-associated immunoglobulin (Ig)-like receptor-1 (LAIR-1), signal inhibitory receptor on leucocytes-1 (SIRL-1), CD31, signal-regulatory protein alpha (SIRPα), Siglec-9, CD200R, immune receptor expressed on myeloid cells-1 (IREM-1) and the membrane-bound ligand CD200 was studied by flow cytometry on leucocytes in cord blood (n = 14), neonatal venous blood (n = 24) and adult venous blood (n = 22). Expression of LAIR-1, CD31 and CD200 was increased consistently across all neonatal T cell subsets. Neonatal monocytes exhibited decreased expression of LAIR-1 and IREM-1 compared to adults. Furthermore, cord blood and neonatal venous blood samples contained a distinct LAIR-1-positive neutrophil population, which was not detected in adult blood. We demonstrated distinct expression of inhibitory receptors on neonatal peripheral blood immune cells in a healthy birth cohort. This is the first evidence that inhibitory receptors play a role in regulation of the neonatal immune system. Consistently increased inhibitory receptor expression on T cells may be an important mechanism in preventing the development of allergy and autoimmunity.
Cells-Self extracellular matrices-based bioinks to create accurate 3d diseased skin tissue models

It has been recognized that growing cells within 3D structures reduces the gap between 2D in vitro cell cultures and native tissue physiology. This has been paving the way for the development of reliable 3D in vitro cell-based platforms with major impact in the reduction/elimination of animal experimentation, diseases modelling and drug development. So far, the many strategies that have been followed to bioengineer in vitro 3D human tissue models mostly rely on the random culture of cells within a 3D structure without reflecting the compositional and structural complexity of the native tissues. Recently proposed bioprinting technologies that allow accurate and high speed deposition of various cells and matrices at high resolution, have therefore great potential in the development of physiologically reliable 3D in vitro tissue models by recreating the different microenvironments/microfunctionalities found in each tissue. Nonetheless, among the components required for bioprinting, bioinks in particular have demanding requirements and much has still to be done regarding their intrinsic formulation to lead cell behaviour and support specific functionalities.
ECM_INK intends to tackle this issue by developing cells-self extracellular matrices-based bioinks to create accurate and pathophysiological relevant 3D in vitro diseased skin tissue models. The development of cell phenotype-driven bioinks will generate complex microenvironments comprising varied cell types within matrices that were specifically designed to attain a particular response from each one of those cell types. The use of cells from patients suffering from chronic, genetic and neoplastic skin diseases represents a major advantage that will be reflected in the accuracy and functionality of the respective 3D in vitro models. The ultimate confirmation of their potential will be complete after validation using animal-free approaches reinforcing the intrinsic relationship of ECM_INK with the 3Rs policy.
Laubschutzsystem für Kasten-Dachrinnen

Dachrinnenabdeckung zum Zwecke des Laubschutzes in Form eines Lochblechs aus Kunststoff oder Metall mit einer nahezu vollflächigen Lochung dadurch gekennzeichnet, dass es der Länge nach in etwa 1 cm Abständen so geknickt werden kann, dass es auf die Breite der Kastenrinne angepasst werden kann (Zeichnungen A und B).
Hydrogen production by oxidative steam reforming of methanol over Ni/CeO2–ZrO2 catalysts

Abstract Single ZrO 2 and mixed CeO 2 –ZrO 2 oxides with different CeO 2 /ZrO 2 ratios were prepared by the sol–gel method and the CeO 2 by precipitation. The prepared support were impregnated with an aqueous solution of NiCl 2 ·6H 2 O at an appropriate concentration to yield 3 wt.% of nickel respectively in the catalysts. Catalytic materials were characterized by BET (N 2 adsorption–desorption), SEM-EDS, XRD and TPR. The oxidative steam reforming of methanol (OSRM) reaction was investigated on these catalysts for H 2 production as a function of temperature. Depending of the CeO 2 /ZrO 2 ratio; the catalysts composition has a significant influence on the surface area (BET), reduction properties and methanol conversion. XRD patterns of the Ni-base catalysts showed well defined diffraction peaks of the metallic Ni except on the Ni/CeO 2 catalyst, suggesting that on this sample all of the active phase was highly dispersed. Ni/Ceria-rich catalysts were vastly active for OSRM, giving a total CH 3 OH conversion at 325 °C with GHSV = 0.3 × 10 5  h −1 . They also showed close selectivity toward H 2 , with high selectivity to CO 2 in all range of temperatures, this suggests that the reverse WGS reaction does not occur on these samples. It seems that the nickel is the phase mainly responsible of hydrogen production although the CeO 2 /ZrO 2 support reduces the CO formation.
Strengthen entrepreneurial skills of Cultural and Creative Industries for the valorization of cultural heritage and the development of sustainable tourism models in the Adriatic-Ionian regions

Despite the richness of the cultural heritage in the Adriatic-Ionian (AI) area and its bustling social&cultural life, the tourism offer potential remains still largely unexpressed. Mass tourism schemes, strong seasonalization and concentration of flows in main destinations jeopardize a sustainable development and the undisclosed potential of creativity. Cultural and creative industries (CCIs) play an important role in fostering economic growth, job creation and innovation but are still poorly valued in their economic impact. This is partially due to the lack of strong key competences and the weakness of local ecosystems. 

CCI4TOURISM fixed a clear and ambitious objective: making CCIs key players of the tourism sector and a distinctive factor of growth in the AI macro-region. To achieve this goal new, unconventional approaches to tourism management strategies are needed, where a disruptive mind thinking matters. We want to dedicate the best of our business support services for the success of the cultural&creative sector, hardly working on 

a) Entrepreneurial discovery and talent mobilization.

b) Empowerment of entrepreneurial skills.

c) Hybridization between cultural, creative and tourist businesses, for the creation of new companies and for the design of new products. The main expected result is the enhancement of the entrepreneurial mindset of CCIs bringing them at the heart of a radical change in territorial development and sustainability strategies where cultural heritage is no more an option, but the main point. Main outputs:

1) Transnational Strategy for the strengthening CCIs skills and competences.

2) Setting up of a Creative Hubs network for the heritage valorization as the lighthouses of a renewed concept of creativity and culture where digital make the difference.

3) Transnational action plan for a “Cultural tourism 4.0” offer across the AI area. Transnational approach is crucial to meet and develop successful strategies based that are key for tourism sector growth.
Development of innovative cement concrete with increased durability and tightness using self-healing concrete.

Reference number of the aid programme: SA.42799(2015/X), help_de_minimis: §42 of the Decree of the Minister of Infrastructure and Development of 10 July 2015 on granting financial assistance by the Polish Agency for Enterprise Development under the Operational Programme Intelligent Development 2014-2020.The president plans to commission research and development services to the Department of Construction and Environmental Engineering in order to significantly improve the existing cement concrete product, which will be the target solution, i.e. product innovation at least in the country. The subject of the study is innovative cement concrete with increased tightness and durability with the use of self-repair effect. Innovative features are: —high durability-guarantee of watertightness for 50 years; —tight-limiting water penetration to 3 cm, which protects the reinforcement and interior of the construction made of the concrete concerned; —elimination of coating/coating insulation as a stage of industrial flooring technology; —self repair-damage, which in traditional concrete causes accelerated destruction in the concrete in question will be repaired without interference from outside. In addition, the proposed, competitive solution will meet the requirements of the new European standards – Eurocod 2, which means that it can gain an advantage in the case of exports. The subject matter of the project shall be included in KIS 8 and shall take into account the implementation of 4 tasks within 01.03.2017-31.08.2017: 1.Development of a cement concrete modifier to increase durability and tightness, with particular regard to the use for flooring 2.Development of the programme and implementation of studies covering at least: depth of water penetration at pressure of up to 30 mm, F200 frost resistance and own procedure for designed usability of 50 years, taking into account changes in humidity, temperature, sunshine, freezing cycles, etc. 3.Trying of flooring with Wisdom
Enhancing English-Japanese Translation Using Syntactic Pattern Recognition Methods

In this paper, we present a novel approach to Machine Translation (MT) using syntactic Pattern Recognition (PR) methods. Our aim is to evaluate the possibility of using syntactic PR techniques in this mature field, and to identify any potential benefits that can be gleaned by such an approach. To make use of syntactic PR techniques, we propose a system that performs string-matching to pair English sentence structures to Japanese (The specific languages, namely English and Japanese, were chosen because their sentence structures are completely dissimilar. This, however, proves the point that such syntactic methods will be applicable for other pairs of languages too.) structures – as opposed to matching strings in and of themselves, and to thus facilitate translation between the languages. In order to process the sentence structures of either language as a string, we have created a representation that replaces the tokens of a sentence with their respective Part-of-Speech tags. Further, to perform the actual string-matching operation, we make use of the OptPR algorithm, a syntactic award-winning PR scheme that has been proven to achieve optimal accuracy, and that also attains the information theoretic bound. Through our experiments, we show that our implementation obtains superior results to that of a standard statistical MT system on our data set. Our results provide the additional guarantee of generating a known sentence structure in the target language. With further research, this system could be expanded to have a more complete coverage of the languages worked with. The incorporation of such PR techniques in MT, in general, and the OptPR algorithm, in particular, are both pioneering.
Does a moving hybrid zone leave a genomic footprint?

Species are the currency of biodiversity. However, during the early stages of their evolution, species are difficult to delineate, as barriers to gene flow are not yet complete. Range expansions and contractions exaggerate the reshuffling of the genomes of hybridizing species. The key objective of this project is to experimentally test the theoretical prediction that, under hybrid zone movement, genes derived from a displaced species are left behind in the genome of an invading species, leaving a ‘genomic footprint’. I will fill an empirical void by, for the first time, testing this critical hypothesis in the wild, using genome-scale data. I have established a study system (the newt genus Triturus) that is particularly appropriate because it shows strong evidence in support of hybrid zone movement over considerable time and distance. To obtain genome-wide data, I will be trained in the cutting-edge genomic technique of target enrichment through sequence capture during the outgoing phase at the lab of Prof. Shaffer at the University of California, Los Angeles (UCLA). To transfer this important new piece of knowledge back to Europe, I will implement target enrichment through sequence capture during the return phase at the beneficiary, the University of Sheffield (USFD). At USFD the group of Prof. Butlin has unmatched expertise in hybridization/speciation research and excels in the analytical approaches required to uncover a genomic footprint. Human activities have intensified hybridization and I propose a secondment to work together with conservationists and legislators to tackle the insidious conservation problem of genetic pollution by exotic species.
Fabrication of micro-capacitive inclination sensor by resin molding

Capacitive inclination sensors have the advantage that they can easily provide a linear analog output with respect to inclination. Although inclination sensors featuring this advantages are already commercially available, they are generally too large. We fabricated a micro-capacitive inclination sensor by a combination of a resin forming method and a mold. Electrodes of the sensor are 40 μm in a gap and 12 mm2 in area. The sensor detects difference of capacitance, which varies with movement of silicone oil accompanying with inclination of the sensor. Since the dimensions of the sensing region are 5 × 5 × 3 mm3 this inclination sensor is expected to be widely used in fields where efficient and reliable position control is a primary factor to be considered. The use of resins is also expected to contribute to a reduction in the costs of materials. We successfully fabricated a micro inclination sensor as a molded product. In future, we will wire up the device to complete this inclination sensor, and will then conduct performance evaluations. If techniques using resin-molded parts are introduced to the low-cost mass-production of Micro Electro Mechanical Systems devices, the range of applications will further expand to new areas of technology and industry.
Gutter Design and Business Development for Domestic Rainwater Harvesting Systems: A Case Study

Rainwater harvesting is a simple and effective tool to collect and store water for domestic and institutional use. In developing countries, captured rainwater can be used to replace or supplement government-supplied or manually-transported water. A rainwater harvesting system consists of a catchment area, gutter, and storage tank. Gutters typically have a V-shaped, trapezoidal or rectangular cross-section. This work presents a case study on the design and performance analysis of three conventional and one novel, “wrapped” gutter cross-section along with the implementation of a novel gutter design in the developing world. A Team of undergraduate students performed the design and analysis and, though a service-learning experience in May 2013, investigated barriers to implementing rainwater harvesting in central Kenya. It was found that while gutters can be easily fabrication and installed using locally-available materials and skill-sets, for consumer, the potential return on investment was low and the cost of implementation was high. For producers and installers, non-uniform roof designs and conditions was a major obstacle.
Linear regressive forecasting parallel control strategy of the ship power station

A quick synchronization parallel control strategy for multi-paralleled generators based on linear regressive forecasting algorithm is presented in this paper. The proposed controller consists of a speed regulator of diesel engine and an Air Circuit Breaker (ACB) of synchronous generator. The task of the speed regulator is to automatically adjust frequency and load; ACB is used to control the generator either to work in the ship power system or trip off. Regressive forecasting algorithm is applied to estimate the closing time of a paralleled synchronous generator. The main contribution of this paper is to give some insights into closing instruction of ACB. In this way, to overcome the shortcomings of the parallel method of phase difference, the proposed control strategy is evaluated via power station onboard and the result shows that the accuracy of ACB closing is improved.
METHOD AND PROCESS ARRANGEMENT IN THE SHORT CIRCULATION OF A PAPER MACHINE

A process arrangement in the short circulation of a paper machine comprises devices (10-13) for dilution of thick stock, centrifugal cleaners (14), and a headbox fan pump (16), as well as a pipe system connecting these. There is a direct flow connection from the centrifugal cleaners (14) along a pipeline (30) to the headbox fan pump (16), through which pipeline (30) a centrifugally cleaned stock flow (F6) is passed direct to the headbox fan pump (16) without any deaeration or dilution stages in between. A secondary line (32) is connected to the pipeline (30) for passing through it part of the centrifugally cleaned stock flow as a return flow (F7) back to the thick stock dilution devices (10-13). By this arrangement it can be ensured that the pressure on the suction side of the fan pump (16) remains substantially constant.
Molecular Detection of Staphylococcus aureus by polymerase chain reaction assay in mastitic milk

Staphylococcus aureus is a leading cause of mastitis throughout the world. The aim of the present study was to detect S.aureus directly from mastitic milk using polymerase chain reaction assay (PCR) based on 16S to 23S rRNA intergenic spacer. 564 milk samples were subjected to PCR assays and bacteriological examination. Samples were processed for DNA extraction by phenol chloroform isoamyl alcohol method and then amplified using PCR assay. In case of S.aureus positive milk samples, amplified product size of 420 bp was obtained using optimum concentration of primers, 2X master mix and annealing temperature. Of 564 milk samples, 172 milk samples (30.49%)were characterized as S.aureus by bacteriological examination and other biochemical tests while PCR assay was able to detect 188 (33.33%) samples positive for S. aureus. None of the culturally positive milk sample was found negative by PCR based molecular detection of S. aureus. PCR assay was found rapid, sensitive and specific tool for screening large dairy herd for early diagnosis of mastitis.
Violent settlements: strategic villages and clandestine burial sites in latin america

In contemporary warfare the power to destroy cities exists alongside with the power to built urban places ex nihilo. In the 70s and 80s, various Latin American States forcedly displaced people to villages created as an instrument of counterinsurgency; at the same time massacres and forced disappearances occurred in these regions. How does the simultaneous creation of strategic villages and clandestine burial sites affect the ways of inhabiting and imagining space in the aftermath of political violence? My study aims at analysing for the first time the connexion between mass violence and the forced creation of built environment. Based on qualitative fieldwork undertaken in Tucumán (Argentina) and Ayacucho (Peru) and framed within social anthropology, sociology and human geography, this research will produce a seminal in-depth study of the daily life among the strategic villages in Latin America, by analysing the experience of subjects that were forced to inhabit there.