SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Mapping Reads on a Genomic Sequence: An Algorithmic Overview and a Practical Comparative Analysis

Mapping short reads against a reference genome is classically the first step of many next-generation sequencing data analyses, and it should be as accurate as possible. Because of the large number of reads to handle, numerous sophisticated algorithms have been developped in the last 3 years to tackle this problem. In this article, we first review the underlying algorithms used in most of the existing mapping tools, and then we compare the performance of nine of these tools on a well controled benchmark built for this purpose. We built a set of reads that exist in single or multiple copies in a reference genome and for which there is no mismatch, and a set of reads with three mismatches. We considered as reference genome both the human genome and a concatenation of all complete bacterial genomes. On each dataset, we quantified the capacity of the different tools to retrieve all the occurrences of the reads in the reference genome. Special attention was paid to reads uniquely reported and to reads with multiple hits.
Advanced networking for nuclear education and training and transfer of expertise

The present situation of nuclear energy in Europe asks for a continuing effort in the field of Education and Training aimed to assure a qualified workforce in the next decades. 

In this scenario, the present proposal is aimed at enhancing and networking the Europe-wide efforts initiated in the past decades by different organisations belonging to academia, research centres and industry to maintain and develop Education and Training in the nuclear fields. This will allow consolidating, developing and better exploiting the achievements already reached in the past and to tackle the present challenges in preparing the European workforce in the nuclear fields.

The main objectives of the proposal are:

1. SURVEY AND COORDINATION OF NETWORKING IN E&T AND VET IN THE NUCLEAR AREAS
2. DESIGN AND IMPLEMENTATION OF COORDINATED E&T AND VET EFFORTS (Master and Summer Courses for continuous professional development)
3. GENERATIONAL TRANSFER OF EXPERTISE (Sustainable production of educational material)
4. CROSS BORDER TRANSFER OF EXPERTISE (Implementation of ECVET based exchanges among industrial bodies)
5. REINFORCING ETI ACTIONS FOR SHARING AND ENHANCING NUCLEAR SAFETY CULTURE COMPETENCE
6. FACILITATING THE NUCLEAR TRANSITION IN FUSION: COORDINATING THE E&T ACTIONS

The European Nuclear Education Network (ENEN), as coordinator of the proposed action, together with the other Participants, is committed to pursue the above objectives, being fully coherent with the ones  suggested in the call (NFRP10) and proposed by the SET Plan Roadmap for Education and Training for the nuclear sector, tightening at the same time the links among the different nuclear areas and better coordinating their contributions in the E&T fields. Strict links with the SNE-TP; IGD-TP and MELODI platforms and other relevant associations and bodies (EHRO-N, NUGENIA, EUTERP, IAEA, HERCA, etc.) will be implemented to assure coherence of this effort with similar other efforts going on in Europe.
Pipeline closing apparatus

A pipeline closing apparatus comprises a lid member attachable to a downstream end portion of a sluice valve, a first control shaft extending through the lid member, a second control shaft extending through the first control shaft, an elastic annular member disposed between pressing plates and provided on inward end regions of the control shafts and elastically deformable to a diameter-increased position by being clamped and pressed, thereby to block between an inner peripheral surface of a branch pipe and the pressing plates, and a retaining device. The retaining device includes engaging link pairs flexing and bulging to a diameter-increased position in response to outward sliding movement of the second control shaft relative to the first control shaft. The apparatus further comprises a reversal preventing device F which, contacts and limits the engaging link pairs and to an outwardly bent position where flexing pivotal portions of the engaging link pairs project radially outward.
A Parametric Study of Bionic Airfoil Based on Long-eared Owl Wing

As the bionic prototype,five feature points of the lower surface of the long-eared owl wing are extracted by using the reverse reconstruction technique.The B-spline curve is adopted to establish the bionic airfoil model.Three-dimensional viscous Reynolds-averaged Navier-Stokes equations and SST(shear stress transport) turbulence model coupled with Langtry-Menter transition model are solved to perform the orthogonal experiment.The effects of front arc curvature,leading edge thickness,leading edge angle,lower surface curvature and trailing edge thickness on the lift-drag ratio are investigated.Based on the orthogonal experiment results,an optimal bionic airfoil that suppressed effectively the flow separation under the higher angle of attack is obtained.The numerical results show that the leading edge thickness is the most important factor to influence the airfoil performance. The lift-drag ratio increases while the leading edge thickness is reduced.There are optimal lower surface curvature and trailing edge thickness for the maximum lift-drag ratio of the bionic airfoil.
AEROSOL PROVISION SYSTEM

An aerosol provision system comprising: a substrate comprising aerosol generating medium, the substrate including a first surface and a second surface facing the first surface; a source of energy for heating arranged to face the second surface of the substrate, wherein the source of energy for heating is configured to cause heating of the aerosol generating medium to form an aerosol; and a movement mechanism arranged to enable movement of the aerosol generating medium relative to the source of energy for heating, wherein the aerosol generating medium is rotationally movable relative to the source of energy for heating such that portions of the aerosol generating medium are presented to the source of energy for heating, and wherein the aerosol generating medium is rotated around an axis at an angle to the first surface.
Identification of a Rare Gecko from North Island New Zealand, and Genetic Assessment of Its Probable Origin: A Novel Mainland Conservation Priority?

Abstract The largest extant New Zealand gecko, Hoplodactylus duvaucelii (Duvaucel's Gecko), is a nocturnal, viviparous species of conservation concern. Hoplodactylus duvaucelii, once widespread throughout New Zealand, is now confined to offshore islands, the majority of which are free from all introduced mammalian predators (mice, rats, cats, mustelids, brushtail possums). A single H. duvaucelii, caught within a fenced reserve on North Island in 2010 was genotyped to determine whether it represents a recent introduction or a previously unknown native relict population. Genotypes from seven nuclear loci and a minimum spanning network of mtDNA haplotypes revealed two clusters representing southern (Cook Strait) and northern island populations. This genetic structure is concordant with variation between these two groups observed in body size, color pattern, and scalation. The mainland specimen was found to possess a mixture of morphological character states typical of northern and southern island populations...
Carr·E: lightweight and versatile electric vehicle applied to urban logistics

Spirit Design has designed Carr.e, an innovative urban vehicle that exploit the technical components of e-bikes and applies them to a 4wheeler cargo so to exploit a 125,25M€ (by 2020) business opportunity. We are an internationally leading strategic design company born in 1993 in Vienna.
European cities are expected to reach 75% of the total population by 2020, besides Urban Freight Transport (UFT) represents 8% to 15% of the total.  Urgent is the need of countermeasures to avoid road congestions, lower environmental pollution, from greenhouse gases (25% due to transport) to noise. Besides, e-commerce heavily relies on UFT and B2C sales are growing at a rate of 14% per year, urban logistics need to find solutions that are cost-effective, productive, efficient and environmentally sustainable. 
Consequently, we propose Carr·e, which exploits electric power-assisted cycles features to create a 4-wheeler, innovative pedelec (pedal electric cycle) designed for UFT that needs no driving license and no homologation. Carr.e includes a modular architecture to provide flexible driver protection in a highly space-saving way. Carr.e is designed so that batteries can be easily changed and not recharged. 
Carr.e is supported by the interest of main UFT stakeholders: POST AG, ÖAMTC and REWE and will be manufactured by the KSR Group. Carr·e will accumulate by 2020 a turnover of 125,25M€ and 32 new employees, ROI of 4,71%. Carr·e contributes to the EC goal for UFT of ""CO2-free city logistics in urban centres by 2030"".
Carr·e has been designed to address UFT issues:
•Reduction of urban environmental pollution.
•Increase of the cargo companies' delivery efficiency.
•An extension of B2B market applications for public administrations, SME business and corporations, tourism agencies or large-sized recreational areas thanks to its modularity. 
•Energy efficient and low-cost solution for a wider range of cargo.
•No need to spend time to recharge batteries.
INPUT SENSOR AND DISPLAY DEVICE HAVING THE SAME

An input sensor includes a first pattern and a second pattern overlapping with the first pattern with an intermediate insulating layer interposed therebetween. The second pattern is disposed on the intermediate insulating layer and connected to the first pattern via a contact hole defined through the intermediate insulating layer. The first pattern includes a first mesh line extending along a reference direction, and the second pattern includes a second mesh line extending along the reference direction and overlapping with the first mesh line. An edge of the first mesh line and an edge of the second mesh line are not aligned with each other along a direction perpendicular to a line width direction and the reference direction.
DEVICE FOR SEPARATING AND RETAINING FLUID-SUSPENDED MAGNETIC PARTICLES

The present invention relates to a device for retaining and separating fluid-suspended magnetic particles, the device comprising a filter for a conventional internal combustion engine which includes inlet and outlet means, as well as internal filtration means; the device has at least one arrangement of magnetic means for the separation and retention of magnetic particles, said assembly being located inside the filter and whose function is to catch and retain magnetic particles which circulate suspended in a fluid.
Dynamics of dark energy and scalar field models in non-flat universe

This paper is devoted to study the effect of different scalar field models under the influence of interacting generalized ghost pilgrim dark energy model in the framework of non-flat FRW universe. For this purpose, we examine the behavior of equation of state and Hubble parameters for two different values of interaction term. Moreover, we consider Lagrangian density of quintessence, tachyon, k-essence and dilaton models to check the consistency of dark energy model with scalar field models. We also evaluate their corresponding potentials and discuss the behavior of kinetic as well as potential energies graphically. We also check the consistency of fractional density of matter and dark energy with Planks 2018.
An accurate mass and radius measurement for an ultracool white dwarf

Studies of cool white dwarfs in the solar neighbourhood have placed a limit on the age of the Galactic disk of 8-9 billion years. However, determining their cooling ages requires the knowledge of their effective temperatures, masses, radii, and atmospheric composition. So far, these parameters could only be inferred for a small number of ultracool white dwarfs for which an accurate distance is known, by fitting their spectral energy distributions (SEDs) in conjunction with a theoretical mass-radius relation. However, the mass-radius relation remains largely untested, and the derived cooling ages are hence model-dependent. Here we report direct measurements of the mass and radius of an ultracool white dwarf in the double-lined eclipsing binary SDSS J013851.54-001621.6. We find M(WD)=0.529+/-0.010Msol and R(WD)=0.0131+/-0.0003Rsol. Our measurements are consistent with the mass-radius relation and we determine a robust cooling age of 9.5 billion years for the 3570K white dwarf. We find that the mass and radius of the low mass companion star, M(sec)=0.132+/-0.003Msol and R(sec)=0.165+/-0.001Rsol, are in agreement with evolutionary models. We also find evidence that this >9.5 Gyr old M5 star is still active, far beyond the activity lifetime for a star of its spectral type. This is likely caused by the high tidally-enforced rotation rate of the star. The companion star is close to filling its Roche lobe and the system will evolve into a cataclysmic variable in only 70 Myr. Our direct measurements demonstrate that this system can be used to calibrate ultracool white dwarf atmospheric models.
AWNING WITH FLEXIBLE SOLAR MODULES

An awning has a frame (12a, 12b, 12c) and a flexible canopy (1) mounted to the frame so as to be retractable into a retracted position and extendable into an extended position. The canopy has flexible solar modules (2). The frame has a roller onto which the canopy is rolled in the retracted position. At least one storage cell is connected to the solar modules and mounted in the roller. It stores electrical energy produced by the solar modules (2). The awning can be operated by the energy stored in the storage cell.
Deep earth elastic properties and effective rheology

The interface between the Earth’s rocky mantle and molten outer core, located 2900 km below the surface, is marked by a patchwork of enigmatic structures. These structures, revealed by anomalous reductions in the speed of traveling seismic waves, are characterized by high density, partial melting, and low topographic heights (10-40 km above the core-mantle boundary). Due to the low seismic wave speeds, they are called UltraLow Velocity Zones (ULVZs). Since their ﬁrst discovery in the 90s, our understanding of the ULVZs has been based on seismic observations. The inﬂuence of microscale distribution of melt and minerals on the seismic signature and the internal structure of the ULVZs remain a challenging question in geophysics. To address this question, this project will use a cross-scale approach to quantify the inﬂuence of partial melting and solid composition on the elastic properties and rheology of the UL-VZs based on a microstructural model. Using the microscale constraints on the physical properties, the km-scale internal structure of the ULVZs will be simulated using a ﬁnite elements model.

The interdisciplinary approach of this project relies on using state-of-the-art high performance computational ﬂuid mechanics models to answer fundamental questions in Earth Sciences. The uniqueness of this approach arises from the special consideration of microstructures, a crucial, but difﬁcult to quantify aspect in Earth sciences. The multidisciplinary aspect of this work will train the researcher in new modeling skills. Upon his return to India, where research in deep Earth is still in its infancy, the researcher will be able to establish his own research agenda leading the country’s effort in that area. Continued inter-national collaboration between the host institution and the researcher’s future group will be of enduring value to the EU.
Epigenetics, experience and responsibility: implications for neurodevelopmental disorders

In folk psychology and in bioethical discussions, the central dogma of genetics is often taken for granted: humans are seen as defined in a genetic blueprint. The conceptualization of psychiatric conditions as innate or acquired, biological or psychosocial, genetic or environmental, influences the ascription of both capacity responsibility (the capacity to adapt or adjust one’s own behavior) and normative responsibility of individuals or the society towards those diagnosed. But findings in the field of epigenetics indicate that the social and physical environment influence how genes are expressed. Indeed, epigenetics may shed a new light on distinctions such as innate/acquired, genetic/environmental, biological/psychosocial: a far more complex view on neurodevelopmental disorders may emerge, with ethical implications. However, the implications of epigenetics for discussions on the scope and extent of normative responsibility have not been adequately addressed. 

NEUROEPIGENETHICS aims to investigate the ethical implications of epigenetics for neurodevelopmental disorders. We will use theoretical and empirical methods to investigate how certain concepts (innate/biological/genetic) affect the ways in which professionals and stakeholders (persons with a neurodevelopmental disorder and their families) conceive of responsibility. We will evaluate how the emerging field of epigenetics alters the ascription of capacity responsibility and normative responsibility. We will research how individuals with Autism Spectrum Disorder (ASD), Tourette Syndrome (TS) and Attention Deficit Hyperactivity Disorder (ADHD)and their families experience the interaction between their condition and their biological and social environment. Finally, we will define moral responsibility in light of the emerging field of epigenetics in the area of neurodevelopmental disorders and child psychiatric practice.
Spectrum of Clinical Symptoms in Children with Elevated Lactate: Pyruvate Ratio in a Tertiary Care Setting

Introduction: This study is designed to study clinical symptoms in children with elevated lactate: pyruvate ratio to understand the magnitude of respiratory chain disorder. 
Materials and Method: Children attending pediatric outpatient department in our center who showed clinical symptoms suggestive of inherited metabolic disorder were enrolled into the study. Arterial blood gas, lactate and lactate: pyruvate ratio were analysed by collecting arterial blood from selected children. Clinical symptoms of those children with elevated lactate: pyruvate ratio was evaluated. 
Result: 304 patients who showed clinical symptoms of either developmental delay without asphyxia, seizures, vomiting, poor suck or weak cry at birth were evaluated. Of them 147 showed one or more of positive biochemical findings such as metabolic acidosis, elevated lactate or lactate: pyruvate ratios which were the basic laboratory data to suspect energy metabolic disorder. Elevated lactate: pyruvate ratio was found in 81 patients, which is one of the biochemical markers to narrow down diagnosis of respiratory chain disorder. 
Conclusion: Our study showed that suspected energy metabolic disorders are not uncommon. Clinical suspicion is crucial to start further diagnostic profile. Children with delay in attaining milestones despite being born at term without asphyxia need to be referred for metabolic work up. There is a need to create awareness in primary health care providers about this in order to initiate further diagnosis and intervention. Elevated lactate: pyruvate ratio suggests this and warrants further work up. Serum alanine and beta-hydroxy butyrate: acetoacetate ratio may help us to know more about energy metabolic disorders like respiratory chain disorders.
A diagnostic approach to pruritus.

Pruritus can be a symptom of a distinct dermatologic condition or of an occult underlying systemic disease. Of the patients referred to a dermatologist for generalized pruritus with no apparent primary cutaneous cause, 14 to 24 percent have a systemic etiology. In the absence of a primary skin lesion, the review of systems should include evaluation for thyroid disorders, lymphoma, kidney and liver diseases, and diabetes mellitus. Findings suggestive of less serious etiologies include younger age, localized symptoms, acute onset, involvement limited to exposed areas, and a clear association with a sick contact or recent travel. Chronic or generalized pruritus, older age, and abnormal physical findings should increase concern for underlying systemic conditions. Initial evaluation for systemic disease includes complete blood count and measurement of thyroid-stimulating hormone, fasting glucose, alkaline phosphatase, bilirubin, creatinine, and blood urea nitrogen. Hodgkin lymphoma is the malignant disease most strongly associated with pruritus, which affects up to 30 percent of patients with the disease. Chest radiography is needed when lymphoma is suspected. A wheal and flare response indicates histamine-induced pruritus in patients with urticaria or an allergic dermatitis. These patients benefit from continuous dosing of a long-acting antihistamine. Second-generation antihistamines, such as cetirizine, loratadine, and fexofenadine, may be more effective because of improved patient compliance.
Blue Growth Community - Capitalization & Communication project for Blue Economy Innovation in the Mediterranean

Interreg Med promotes horizontal projects, which main objective is to ensure the communication/capitalisation activities of modular projects in order to increase their impacts towards common identified targets and “increase the transnational activity of innovative clusters and networks of key sectors of the MED area" (S.O.. With a specific focus on non-financial support to SMEs, BG therefore proposes concrete activities to enhance the capitalization nature of this second phase, going beyond the reinforcement of the cross-cutting and integrated approach between modular projects and transnational key stakeholders. BG enhances the dissemination and transferability of modular projects results to ensure stronger, wider and deeper capitalization, mainstreaming and strategic liaising processes aimed at external multilevel stakeholders, allowing a better take-on of technical modular projects results into policy-making at a multi-level governance scale, and benefitting the further development of the blue economy and entrepreuneurship notably for SMEs. These actions also keep contributing to the sustainable socio-economic development of the Med area through innovative investments in the Blue economy, while ensuring a close communication and coordination with PANORAMED as with key on-going Mediterranean strategies and initiatives (WestMed, BLUEMED...). The results will reach not only the projects and programmes scales, but also beyond, at the Member States & Mediterranean levels.
NOVEL 3,4-DIARYL THIOPHENES AND ANALOGS THEREOF HAVING USE AS ANTIINFLAMMATORY AGENTS

A class of 3,4-diaryl substitued thiophene, furan and pyrrole derivatives and analogs thereof, pharmaceutical compositions containing them and methods of using them to treat inflammation and inflammation-related disorders. Compounds of particular interest are defined by formula (I), wherein Y is selected from O, S and NR<1>; wherein R<1> is selected from hydrido and lower alkyl; wherein X is one or two substituent selected from hydrido, halo, lower alkoxycarbonyl and carboxyl; wherein R<2> and R<3> are independently aryl or heteroaryl; and wherein R<2> and R<3> are optionally substituted at a substitutable position with one or more radicals selected from sulfamyl, alkylsulfonyl, halo, lower alkoxy and lower alkyl; or a pharmaceutically-acceptable salt thereof.