SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Technical Note: Geotechnical Examination of the Geophysical Properties of Olokoro Borrow Site Lateritic Soil for Road Works

This present work was carried out to determine the geotechnical properties of Olokoro lateritic soil. Tests were carried out on the sample soil which includes the Atterberg limit tests, particle size distribution analysis; sedimentation test, compaction test using the West African standard and California Bearing Ratio (CBR) test as specied by the Nigerian General specication (1997). The liquid limit, plastic limit and plasticity index were found to fall into A-2-7 soil of AASTO classication and SP group of Unied Classication. The compaction characteristics of the soil were found to be 1.90mg/m3 and 14.76% for maximum dry density and optimum moisture content respectively on West African Standard. The CBR value was found to be 26%. It was recommended that the soil is good as a lling material in road subgrade and other construction works and require modication to improve its properties for sub-base and road base material. Keywords: olokoro lateritic soil, particle size distribution, compaction test, geophysical properties, california bearing ratio
Unique virtual reality solution recreating live indoor sports to increase audience

Nowadays, a major multibillion dollars battle about sports TV rights is going on between new digital players and traditional broadcasters. Sports TV rights on sports broadcasting images have never been so expensive. Increasing each year they reached more than € 40Bn in 2016. Stakeholders are looking urgently for new alternatives solutions to maintain attractiveness in an ocean of contents.
Mac-Lloyd has designed SPIKE a new extended reality (XR) broadcasting solution, alternative to TV images for indoor sports, based on a precise and powerful tracking system.  It is a significant new business opportunity for innovative virtualised sport contents associated to “live” or “on demand” immersive user experience. 
Mac Lloyd comes from outdoor sports and events tracking systems. Indoor sports synthetic images are the natural next market. From a technological perspective it is challenging area. SPIKE requires real time tracking data for indoor sports.
The interest of potential clients is big. Several discussions are on-going with international organizations, such as European sports teams, USA NBA and event organizers. Sports media is a growing worldwide market (€40Bn, +5%/year), and indoor sports is taking a large part of it. Major leagues like NBA gathers 13% of North America media rights and 6% of worldwide rights.
SPIKE SME Instrument project will allow the company to develop and industrialize its advanced XR solution, necessary for a global commercialisation. Mac-Lloyd will first complete a feasibility study to further analyze risks and costs, targeted markets regulatory frameworks and will conduct in-depth analysis of the global indoor sports XR broadcasting market. 
Mac-Lloyd plans to make deals with some of the 50 most valuable sport events worldwide (NBA playoffs, summer Olympic games, North American Hockey..) to become a European and worldwide champion of live indoor sports XR market with a planned turnover of €50 million by 2024 and the creation of 80 new jobs.
Territorial analysis of spatial progress and integrated development opportunities of large lakes in Europe

In the European Union there is not any specific approach developed for the integrated development for regions of large lakes, their social-economical space and catchment areas. This targeted analysis is aimed at overcoming that challenge and to provide to stakeholders’ regions and other regions in Europe recommendations for developing an effective spatial development tool for European large lakes.

By doing so, this targeted analysis is mainly focused on territorial policies and lake governance aspects, but due to the ecological dimension and environmental regulation of large lakes, consideration of environmental conditions is also necessary. The following key concepts are to be considered: place-based approach; multifunctionality; effective territorial governance, environmental regulations.

The project will also provide recommendations mainly to practitioners on how to identify and consider the specific territorial context and specificities in lake regions across Europe for better management and for integrated development of European large lakes.
PENERAPAN PP NO. 46 TAHUN 2013 MENGENAI PPh FINAL 1% DAN DAMPAKNYA PADA PENERIMAAN PAJAK DARI SEKTOR UMKM DI KOTA MALANG

This study was aims to describe the application of Regulation no. 46 of 2013 on the income tax final of 1% on MSMEs (Micro Small Medium Enterprises) and its impact on tax revenues from the SME sector in the city of Malang.

Data collection techniques used is questionnaires. A questionnaire was used to collect data regarding the information about understanding and awareness the about the obligations owner of MSMEs in the field of taxation, government regulations information of understanding for MSMEs about application of government regulation no.46 in 2013 and information about role of government in application taxation for SME. 

Data analysis technical is to tabulate the data from questionnaires, analyzing MSME income tax calculation, and apply the results of the analysis and then make conclusions. 

The results of the analysis are MSME owners understand the tax obligations that should be done, the owners of MSMEs do not have enough of understand the PP 46 in 2013, the socialization of the application of Regulation 46 of 2013 has not been felt by SMEs. 

Keywords: taxes, PP No. 46 of 2013, MSMEs
Projected 21st century decrease in marine productivity: a multi-model analysis

Abstract. Changes in marine net primary productivity (PP) and export of particulate organic carbon (EP) are projected over the 21st century with four global coupled carbon cycle-climate models. These include representations of marine ecosystems and the carbon cycle of different structure and complexity. All four models show a decrease in global mean PP and EP between 2 and 20% by 2100 relative to preindustrial conditions, for the SRES A2 emission scenario. Two different regimes for productivity changes are consistently identified in all models. The first chain of mechanisms is dominant in the low- and mid-latitude ocean and in the North Atlantic: reduced input of macro-nutrients into the euphotic zone related to enhanced stratification, reduced mixed layer depth, and slowed circulation causes a decrease in macro-nutrient concentrations and in PP and EP. The second regime is projected for parts of the Southern Ocean: an alleviation of light and/or temperature limitation leads to an increase in PP and EP as productivity is fueled by a sustained nutrient input. A region of disagreement among the models is the Arctic, where three models project an increase in PP while one model projects a decrease. Projected changes in seasonal and interannual variability are modest in most regions. Regional model skill metrics are proposed to generate multi-model mean fields that show an improved skill in representing observation-based estimates compared to a simple multi-model average. Model results are compared to recent productivity projections with three different algorithms, usually applied to infer net primary production from satellite observations.
Healthcare performance intelligence professionals

Balancing between improving population health, delivering quality care for individuals, and containing costs is a timely social/economical challenge in Europe. There is great potential achieving this through healthcare (HC) system performance intelligence optimizing effective use of available HC data in countries. Effective implementation of HC performance intelligence (HPI) by skilled professionals will improve integrated service delivery; patient engagement; equality in access to HC; health outcomes; and reduce waste in HC. Translating HC data into meaningful, valid, actionable performance intelligence that is transferrable into actions to improve HC systems requires multidisciplinary skills & innovative competencies; currently not well developed in training programmes and the scientific community and missing in today’s European HC market. The ETN for HPI Professionals (HealthPros) fills this gap and directly impacts the European Research Area by training innovative “Healthcare Performance Intelligence Professionals” uniting a multidisciplinary consortium tackling private, public, academic sectors.13 ESRs will be trained in multidisciplinary innovative scientific technical and complementary skills, seconded to private / public / academic HC sectors in multiple countries and build relations with potential future employers. 5 ESRs work on PhD projects related to HC performance measurement optimizing the use of available registry and administrative data and applying statistical models to provide actionable input to HC performance management. 4 ESRs work on PhDs to translate performance intelligence into value-creating HC governance mechanisms; 4 ESRs work on PhDs aimed to impact the actual use of performance intelligence by different end-users. ESRs will have unique HC data access.
Engineering the AAV capsid to optimize vector–host-interactions

Adeno-associated viral (AAV) vectors are the most widely used delivery system for in vivo gene therapy. Vectors developed from natural AAV isolates achieved clinical benefit for a number of patients suffering from monogenetic disorders. However, high vector doses were required and the presence of pre-existing neutralizing antibodies precluded a number of patients from participation. Further challenges are related to AAV's tropism that lacks cell type selectivity resulting in off-target transduction. Conversely, specific cell types representing important targets for gene therapy like stem cells or endothelial cells show low permissiveness. To overcome these limitations, elegant rational design- as well as directed evolution-based strategies were developed to optimize various steps of AAV's host interaction. These efforts resulted in next generation vectors with enhanced capabilities, that is increased efficiency of cell transduction, targeted transduction of previously non-permissive cell types, escape from antibody neutralization and off-target free in vivo delivery of vector genomes. These important achievements are expected to improve current and pave the way towards novel AAV-based applications in gene therapy and regenerative medicine.
Nest density, egg conspicuity, vegetation structure and seasonality affect artificial nest predation in the Brazilian Cerrado

Abstract Nest predators use visual, acoustic and chemical cues to locate nests. In the Neotropics, predation is high being the main cause of nest failure. Despite that, it is still not completely clear what kind of information predators are using to find nests or whether predators respond differently according to habitat characteristics. Here, we executed an experimental manipulation to investigate how different ecological factors influence nest predation probability. We hypothesised that egg conspicuousness, nest clustering and a more open vegetation structure would increase nest predation probability, and that nest predation would be higher during the breeding season of most avian species in the region. We used artificial nests baited with plasticine and quail eggs ( Coturnix coturnix ), manipulated egg coloration and nest density. Artificial nests were distributed over forest and savanna-like vegetations. Overall predation rate was 40.9%. We found that nests baited with conspicuous eggs, located in open habitats, at higher densities and during the dry period were more predated. Results suggest that main predators must be visually orientated, and that egg crypsis is an important trait for open-nest species in the area. Moreover, a higher nest density may affect predator behaviour, favouring an increase in nest searching, which may be facilitated in open habitats.
Mechanism for fostering innovation in South East Europe

SEE countries elaborate and implement the innovation policies with various level of effectiveness. There is a lack of cooperation, capacity and common understanding of innovation performance, policies and supporting instruments in the region. The aim of the FINNO project is to contribute to better productivity and achieve more comparable level of innovativeness between countries in SEE region. The project will create a communication platform of decision-makers supported by sustainable mechanism for fostering innovation in SEE area, the FINNO Committee, a legal body providing governance level with constant and relevant policy recommendations. The mechanism for fostering innovation in SEE region will be developed in the project by key innovation supporting actors. On the basis of the analysis of innovation performance and existing measures in SEE countries and region, a common methodology for measuring Technology Innovation Assessment Scoreboard (TIAS) will be developed. TIAS Scoreboard rate will be measured in companies as direct users of innovation supporting measures by the pilot application of the on-line Self-Assessment Tool (SAT). On the basis of identified TIAS rate and identification of existing economy and policy gaps, policy recommendations for the FINNO Committee will be prepared, while enhancing capacity of stakeholders. Main project results include coherent methodology for implementation and usage of TIAS and SAT, innovation policy recommendations for each participating country and establishment of the FINNO Committee to ensure durability after project end. Results achieved will provide an overview of innovation efforts of the involved SEE countries in a unified and comparable way, also enabling benchmarks with other European regions. Results will be disseminated throughout the entire project, providing relevant stakeholders with useful guidelines on how to improve innovation policy and measure innovation performance in their country and beyond.
Malaja — Packaging Centre for Online Shops

The purpose of the operation is to successfully build a packing centre for online shops, to expand it to the wider European market and to help local businesses expand into foreign markets in Europe.
Internationalisation de la marque de produits Camfero à la suite de la mise en œuvre du programme de promotion de l’industrie

SA 42799(2015/X) CAMFERO en tant que marque est sur le marché depuis 5 ans, dont 4 ans d’activité d’exportation. L’entreprise fabrique des meubles en métal. Actuellement, l’entreprise emploie 8 personnes et crée ses propres collections chaque année. La société a développé son image sur le marché et a une position établie. CAMFERO est considéré comme un fournisseur de meubles métalliques de haute qualité et le rapport qualité-prix proposé est très compétitif. Le projet concerne le programme de promotion de l’industrie du meuble. Les marchés tournés vers l’avenir où seront menées les activités du programme de promotion de l’industrie sont les suivants: Marchés des Émirats arabes unis, de l’Ukraine et de l’Europe: Italie, France, Allemagne. Activités promotionnelles entreprises dans le cadre du projet: 1. Index International Design, Émirats arabes unis, Dubaï, 09.2020 (stand national) 2. Varsovie Home, Pologne, Varsovie, 10.2020 3. IMM Koln, Cologne, Allemagne 01.2021 4. Kiff Ukraine, Kiev, 02.2021 5. Salone del Mobile Milan, Italie, 04.2021 6. Maison Obje France, Paris, 09.2021 7. Varsovie Home, Varsovie, 10.2021 8. IMM Koln, Cologne, Allemagne 01.2022 9. Maison Obje France, Paris 01.2022 10. Salone del Mobile Milan, Italie 04.2022 Supplémentaire: — service de conseil pour le marché potentiel: Le projet sera financé par les fonds propres de l’entrepreneur et la subvention obtenue. Le demandeur demandera un paiement anticipé pour la mise en œuvre du projet.
Artificial intelligence expert to boost growth of a high-potential digital diagnostics start-up

Ellogon AI is an innovative start-up established in 2019 as a spin-off from University of Amsterdam, by leading academic experts in artificial intelligence, medical imaging, and computational pathology. The company develops a unique approach to analysis of complex histopathology images of tumour biopsies by directly connecting them to treatment outcomes. The developed technology is based on self-learning algorithms able to analyse whole-slide image big data and with a near-perfect accuracy to identify and detect specific cellular structures serving as potential cancer biomarkers. The company’s leading product will be the first AI-driven digital biomarker to assess the anti-tumor immune response in biopsies using identification and quantification of tumour infiltrating lymphocytes (TILs). The company’s future strategy is to integrate clinical/genomic data with multiple visual biomarkers for >95% accurate diagnostics and prediction of treatment outcome. Currently, only the management team works for the company and seeks to recruit the core technology expert associate that will be in charge of the technology development, with the outlook to become the leader of the development team and eventually the chief technology officer (CTO). In the company’s strategy to build leading technology expert team, filling this particular vacancy represent the critical recruitment milestone. The associate will develop and expand skills in high-performance machine learning applications working with state-of-the-art deep learning models, but also towards managing position in innovative small enterprise. The proposed grant will allow the company to secure the necessary financial resources to overcome the competition (scarcity in the candidates/ salary level) and resources barrier, as well as the visibility barrier to attract the needed expert. Competition in the national market is severe, hence acquiring talent outside the Netherlands is necessary.
Ras/C-Raf interaction: a new pharmacological target in kras-driven lung cancer.

Lung adenocarcinoma is the most frequent subtype of lung cancer and patients harbour activating mutations in the KRAS gene in approximately 25% of the cases. Unfortunately, regardless of the outcome of recent studies identifying specific KRASG12C inhibitors, so far, oncogenic KRAS is not a druggable target yet. The best-characterized KRAS effector pathway, the ERK cascade consists of RAF, MEK and ERK proteins that can be inhibited with small molecules targeting their kinase activities. As the development of RAF and MEK kinases inhibitors progressed, feedback loop reactivating the ERK cascade have emerged, inducing resistance to treatment. Thus, new innovative strategies are needed to achieve a more long-term inhibition of this signalling pathway, while reducing detrimental side effects due to MAPK inhibition in normal cells. It has been described more than 20 years ago that RAF directly interacts with RAS through its Ras Binding Domain (RBD), and many research groups have been trying to disrupt this interaction developing allosteric inhibitors as a cancer therapy. At the moment, those molecules need to be improved in order to achieve a strong inhibition of this pathway. Surprisingly, no mouse model actually demonstrates the requirement of RAS/RAF interaction during KRAS-induced lung tumourigenesis. Here, we propose to investigate this crucial question using a new mouse model allowing us to conditionally disrupt RAS/RAF interaction in vivo. Using the leading mouse model to study lung cancer (LSL-KrasG12D/+; p53-/- mice), we will take advantage of both Cre/LoxP and FLIPo/Frt technologies to investigate the role of RAS/RAF interaction during lung tumours maintenance, as well as its function in tumour/host crosstalk and normal physiology. All together, these investigations will provide important insights into the clinical relevance of developing RAS interaction inhibitors for the treatment of RAS-driven tumours.
Liquid biopsies and imaging for improved cancer care

LIMA’s overall objective is to develop and validate technologies and tools to include liquid biopsies in the clinical workflow, aiming at introducing a more precise and dynamic genetic characterization of tumor at the diagnosis and during treatment phases. This will be done by combining molecular information from liquid biopsies and direct in-vivo tumor characterization from advanced MR imaging, taking into account the current clinical workflow.
The LIMA project will be based on following 5 conceptual pillars:
1. A robust method to measure and genomically analyze ct-DNA for tumor-driving mutations, which can be measured in a quantitative manner allowing therapy response prediction and monitoring.
2. A workflow for Circulating Tumor Cell isolation and computational model-based quantitative signal pathway analysis on single CTC mRNA expression levels. This allows for assessment of tumor heterogeneity in pathway activity (to relate back to tumor heterogeneity), targeted therapy response prediction and monitoring
3. Correlation of computational, model-based cancer pathway activity assessment from cancer tissue samples before and after neoadjuvant treatment and from liquid biopsies with MR imaging features.
4. Advance in MR imaging to better probe and image the cancer lesion and its microenvironment 
5. Clinical analysis, correlating liquid biopsy/imaging –based results to clinical outcome, that is the response to (targeted drug) neoadjuvant therapy in selected breast cancer and rectal cancer patients.
These 5 pillars will be investigated in longitudinal observational studies that will follow patients undergoing neoadjuvant treatment (either chemotherapy or targeted therapy or the combination) for primary rectal and breast cancer. LIMA will demonstrate that prediction of drug therapy response, monitoring of response and detection of resistance can be improved over the current state of the art.
Pulleys' Axial Movement Mechanism for Electro-Mechanical Continuously Variable Transmission

Pulley-based continuously variable transmission (CVT) with Metal Pushing V-belt (V-belt) is a type of automotive transmission that is widely applied currently by many car manufacturers worldwide. Unlike the conventional automotive transmissions, in a pulley-based CVT with V-belt, the transmission ratio (CVT ratio) is changed continuously without the use of discrete gears. Instead, the CVT ratio is varied through the simultaneous axial movement of the primary pulley and the secondary pulley. By axially moving both pulleys simultaneously, the radius of the V-belt on both pulleys will be changed accordingly, resulting in the change of the CVT ratio. The existing pulley-based CVTs in the market use electro-hydro-mechanical (EHM) actuation system to change and to maintain the desired CVT ratio through the hydraulic pressure. However, the application of EHM actuation system leads to some disadvantages, particularly in term of the high power consumption from the engine needed to maintain the desired CVT ratio. This reduces the efficiency of the powertrain system, which eventually increases the fuel consumption of the vehicles. In addition to that, the existing pulley-based CVTs also use single acting pulley mechanism to axially move the pulleys for changing the CVT ratio. Therefore, the issue of V-belt's misalignment, which shortens the lifespan of the V-belt, is inevitable here. In this paper, the pulleys' axial movement mechanism that uses electro-mechanical (EM) actuation system is proposed. Consequently, the working principle of the proposal is described and its potential benefits are discussed.