SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
The Rich Club of the C. elegans Neuronal Connectome

There is increasing interest in topological analysis of brain networks as complex systems, with researchers often using neuroimaging to represent the large-scale organization of nervous systems without precise cellular resolution. Here we used graph theory to investigate the neuronal connectome of the nematode worm Caenorhabditis elegans, which is defined anatomically at a cellular scale as 2287 synaptic connections between 279 neurons. We identified a small number of highly connected neurons as a rich club (N = 11) interconnected with high efficiency and high connection distance. Rich club neurons comprise almost exclusively the interneurons of the locomotor circuits, with known functional importance for coordinated movement. The rich club neurons are connector hubs, with high betweenness centrality, and many intermodular connections to nodes in different modules. On identifying the shortest topological paths (motifs) between pairs of peripheral neurons, the motifs that are found most frequently traverse the rich club. The rich club neurons are born early in development, before visible movement of the animal and before the main phase of developmental elongation of its body. We conclude that the high wiring cost of the globally integrative rich club of neurons in the C. elegans connectome is justified by the adaptive value of coordinated movement of the animal. The economical trade-off between physical cost and behavioral value of rich club organization in a cellular connectome confirms theoretical expectations and recapitulates comparable results from human neuroimaging on much larger scale networks, suggesting that this may be a general and scale-invariant principle of brain network organization.
Identification and characterization of cis-regulatory moduledysfunction in rett syndrome with roq-wach

Precise regulation of gene expression is achieved through the coordinated action of genomic cis-regulatory modules (CRMs). The identification of CRMs has long been a goal of functional genomics as CRM dysregulation can have devastating consequences for health and development such as autism. For example, mutations in the MeCP2 gene, which encodes protein that binds methylated DNA and regulates gene expression in neurons, results an Autism Spectrum Disorder termed Rett Syndrome. While thought to modulate CRM activity as a repressor, MeCP2’s function remains ambiguous and would benefit from a functional genomics characterization. To identify CRMs I recently developed a novel approach called FIREWACh. Here, I propose to utilize FIREWACh first to identify active CRMs within a homogenous population of neurons, identifying genomic loci of CRMs whose function may be compromised by MeCP2 mutations. I will adapt FIREWACh to allow the quantification of CRM output in a new method I propose to call ROQ-WACh (regulatory output quantification within accessible chromatin) by addition of barcodes to reporter mRNAs. This will allow high-throughput readout of CRM activity globally in vivo and will be broadly applicable to many biological fields. Lastly, I aim to combine the above approaches to quantify the changes in CRM output in response to pathological mutations in MeCP2. This Marie Sklodowska-Curie Action will allow me (the Experienced Researcher, Matthew Murtha) mobility to Spain to join the laboratory of Dr. Manel Esteller (Host Supervisor), renowned epigeneticist and expert in DNA-methylation biology to perform the research. Together the approaches and data generated by this MSCA action will provide key insights into the relationship between methylated DNA, precise control of gene expression, and high-order phenotypes such as cognitive behaviors.
IN SITU FORMATION OF CATALYTIC CIGARETTE PAPER

Methods for the in situ formation of catalyst particles (108) in cigarette paper (100) are provided. A catalyst precursor, which can be incorporated into the cigarette papermaking process or can be combined with cigarette paper after formation of the paper, can be decomposed to form catalyst particles (108) that are incorporated within the cigarette paper (104). Cigarette paper (104) comprising the catalyst particles (108) can be used to form a cigarette (100). During the smoking of a cigarette (100) comprising the catalyst particles (108) the amount of carbon monoxide in the mainstream smoke of the cigarette (100) can be reduced.
MULTIGRADE LUBRICATING COMPOSITIONS CONTAINING NO VISCOSITY MODIFIER

This invention relates to shear stable multigrade oils for crankcase lubrication of gasoline and diesel engines which oils are substantially free of viscosity modifier additives and comprise a detergent inhibitor package of lubricating oil additives, which package includes an ashless dispersant comprising an oil soluble polymeric hydrocarbon backbone having functional groups in which the hydrocarbon backbone is derived from an ethylene alpha-olefin (EAO) copolymer or alpha-olefin homo- or copolymer an <o>M</o>n of from 500 to 7000. Such multigrade crankcase oils without viscosity modifiers are more economical and may provide better diesel performance and seal compatibility. The oils are also substantially shear stable and may be used in turbocharged engines and racing engines, with reduced mechanical breakdown of the oil.
Sleep Problems Among Adolescent Survivors Following the 2008 Wenchuan Earthquake in China

To examine sleep problems and associated risk factors among adolescent survivors following the 2008 Wenchuan earthquake, the deadliest earthquake to strike China in 30 years.A cohort of students (N = 1,573) in the 7th and 10th grades from Dujiangyan City, 21 kilometers from the epicenter, was followed up periodically for 2 years. Participants were assessed at 12 months (n = 1,398; May 18-22, 2009), 18 months (n = 1,288; November 23-27, 2009), 24 months (n = 1,313; May 17-21, 2010), and 30 months (n = 1,038; November 22-26, 2010) after the earthquake. Adolescents were asked to complete the Pittsburgh Sleep Quality Index (PSQI; cutoff for sleep problems: total score of ≥ 8), Post-Traumatic Stress Disorder Self-Rating Scale (cutoff for probable posttraumatic stress disorder: ≥ 50), Depression Self-Rating Scale for Children (cutoff for depressive disorder: ≥ 15), Screen for Child Anxiety Related Emotional Disorders (cutoff for clinical anxiety: ≥ 25), Social Support Rate Scale, and Adolescent Self-Rating Life Events Checklist and provide demographic information. Trajectory analysis was used to examine sleep disturbance changes and associated risk factors.Twelve months after the earthquake, 48.90% of participants reported sleeping less than 7 hours per night, 27.68% disclosed difficulties initiating sleep, 8.82% experienced problems staying sleep, 22.60% felt their sleep quality was poor, and 40.01% had difficulties functioning during daytime hours. Overall sleep problems, as assessed by the PSQI global scale, were stable from 18 months to 30 months following the earthquake, and the prevalence rates were between 28.79% and 30.18%. The risk of sleep issues was significantly increased in senior high school students (OR = 2.29) and in those who witnessed the tragic events directly (OR = 1.21). Depression (OR = 1.69), anxiety (OR = 1.57), poor social support (OR = 1.83), and negative life events (OR = 2.62) were also associated with increased risk and persistence of sleep problems.Sleep disturbances are common and persistent in adolescent earthquake survivors. Multiple demographic, psychosocial, and earthquake-related factors are associated with the increased risk of sleep difficulties.
Suicide in Prisoners: An Italian Contribution

It is well-known that suicidal behavior is very common among criminal justice clients, both among those serv- ing community sentences and among prison inmates. Suicide rates among prisoners are considerably higher than in the general population. There is great concern over high rates of suicide and suicidal behavior in prisons, with suicide preven- tion becoming a major challenge for penal institutions in many countries. In particular, Italian prisons are facing an impor- tant crisis. The aim of the present descriptive review is to investigate suicide in prisons, with particular attention to the Italian situation. To date, there are no comprehensive data on this phenomenon for reasons that are critically discussed in this paper. First, we focus on epidemiology, and try to summarize existing heterogeneous data. Demographic, criminologi- cal and clinical risk factors associated with suicide in prisoners are then examined. Understanding the process by which certain prisoners, under specific circumstances, contemplate, plan and decide to end their lives is critical to suicidal pre- vention, as discussed in the third part of the review. Finally, we suggest possible future investigations to improve detection of specific risk factors and we discuss the challenges to be faced in order to decrease suicide rate among prisoners.
Electric energy storage device

A long-life electric energy storage device with superior high-input/output load resistance includes a cathode including a region having a faradic reaction mechanism and a region having a non-faradic reaction mechanism, and an anode including a region having a faradic reaction mechanism. When carbon material contained in the anode is represented by a diffraction line according to X-ray diffraction method, mainly the (001) plane is substantially detected.
Expanding potential in particle and radiation detectors, sensors and electronics in croatia

Modern experiments in astrophysics, nuclear and particle physics depend on specialized and complex detector systems. Development and testing of such unique instrumentation, essential for breakthrough research, requires expertise from a broad range of topics in physics, electronics and computing.  Research institutions able to make significant contributions in this field have a high reputation in the scientific community and increased odds to engage in related large collaborative projects. Participation in such activities requires a significant investment in infrastructure, but often leads to emergent technological progress and potential for technology transfer, positively impacting the local economy. RBI researchers collaborate with top European research centers, and have an excellent knowledge of the experimental techniques involved. However, RBI as an institution insufficiently contributes to instrumentation development. An important step to correct this weakness, and to increase related technological potential of Croatia, including material science, electronics and ICT, was successfully executed by the recently implemented REGPOT FP7 project Particle Detectors. Further actions will be taken through the proposed European Structural and Investment Funds project O-ZIP, designed in line with the national Smart Specialization strategy. PaRaDeSEC will provide funding for the required top staff to consolidate all available resources into the new Center for Detectors, Sensors & Electronics, an independent RBI unit which will strictly implement all conditions to foster state of the art research. The ERA Chair as the Center head will be involved in the RBI management structure and will be an integral component of ongoing structural changes at RBI, based on the best practices of the top EU research centers and ERA priorities. The Center will be focused on nuclear, particle and astro-physics, and is expected to also impact the broader research community and national economy.
Advanced architectures for ultra-thin high-efficiency cigs solar cells with high manufacturability

Advanced aRchitectures for ultra-thin high-efficiency CIGS solar cells 
with high Manufacturability (ARCIGS-M)
This project´s goal is advanced materials and nanotechnologies for novel CIGS PV device architectures with efficiencies ≥ 23.0 %, thus beyond that of the current state-of-the-art technologies. The technology targets the BIPV sector and enables several innovative solutions for BIPV.
The novel functional materials and material combinations are (1) surface functionalized steel substrates, (2) nano-structuring strategies for optical management of rear contact layers, (3) passivation layers with nano-sized point openings, and (4) ultra-thin CIGS thin film absorber layers. The concepts will be developed and established in production viable equipment. Additionally, this new design will also increase the system’s lifetime and materials resource efficiency, mainly due to the use of ultra-thin CIGS layers (less In and Ga), and barrier and passivation layers that hinder alkali metal movement. Hence, this project will lead to enhanced performance, but also yield and stability, while maintaining manufacturability. The consortium includes SME’s and industrial partners positioned throughout the complete solar module manufacturing value chain. Their roles will be to develop and commercialize new equipment, products and/or services. The consortium already pioneered the proposed advanced material solutions up to technology readiness level (TRL) 4, and this project targets to bring these innovative concepts to TRL 6 in a low-cost demonstrator. The aim is to develop and validate innovative, economic and sustainable BIPV applications, as a near future high value market for the European PV industries. An exploitation strategy, developed with the support of TTO (www.tto.dk), identifying BIPV as the most promising market has been used to validate the choice of technologies and will be further developed during the course of the project.
Filed test of comprehensive treatment method for high pressure dynamic grouting

Combining with hydro-geological conditions of No.2 auxiliary haulage roadway of Longgu Coal Mine,principle of security control for underground water disaster was put forward.Geological analysis,comprehensive detection,field tests and real-time monitoring were integrated together.Stratum structure and water source can be judged by geological analysis,aquifer and channel for water are detected by physical technologies,the connectivity conditions of water and grouting materials can be determined by field tests.Based on the above four points,the comprehensive treatment method for high pressure water inflow was found.The method was applied successfully in water plugging in the No.2 auxiliary haulage roadway of Longgu Coal Mine which ensure the security operations and help to save cost significantly for pumping water.It shows that this method has wide application prospect.
Surface lifetime investigation for characterization and enhancement of passivating contacts in c-si solar cells

In the context of high-efficiency solar cells based on crystalline silicon (c-Si), the integration of passivating contacts between the metal electrodes and the c-Si substrate has been identified as the next step to further improve the photovoltaic conversion efficiency. Passivating contacts consisting in a highly-doped poly-crystalline silicon (poly-Si) layer on top of a thin layer of silicon oxide (SiOx) offer the most promising approach to bridge the gap between device efficiencies in R&D and those in production. However, their development has mainly proceeded through “trial and error” so far, resulting in a limited understanding of their underlying working principle. More specifically, the surface passivation provided by poly-Si contacts is a combination of different mechanisms, among which the limiting one is still unclear due to: i) the interplay between these different mechanisms and ii) the challenge of characterizing thin-film stacks with features to the nanometric scale. Moreover, p-type poly-Si contacts, which are of prime interest since they could provide an alternative to the conventional contact at the rear side of mainstream p-type c-Si solar cells, have so far demonstrated lower passivation properties than their n-type counterparts, the fundamental reason for this difference remaining unclear. Within the SLICE project, a dedicated methodology based on lifetime spectroscopy scpecially adapted to the c-Si surface will be applied to identify electrically active defects limiting the lifetime of charge carriers at the interface between poly-Si contacts and the c-Si.  The investigation of different passivating thin-film stacks of iterative complexity will enable to relate their properties to their fabrication process. The insights gained from this original characterization of interfacial defects will support the fabrication of better passivating poly-Si contacts and ultimately solar cells with higher efficiency.
Application of Virtual Reality in Side Clamp Fixture Assembly

Background/Objectives: The main objective of this paper is dealt with the application of virtual reality in side clamp fixture assembly. Methods/Statistical Analysis: The proposed methodology utilized the geometry and assembly details of side clamp assembly and makes the fixture assembly as close as possible to the real one. It includes two stages. The first stage demonstrates the procedure used for creating virtual prototype of an assembly and the second stage includes the creation of virtual fixture assembly. Findings: VRML coding is used to simulate virtual assembly process. Based on interference analysis errors can be rectified. Fixture assembly planning in virtual environment gives better understanding of the design engineer and the virtual assembly planning gives clear detail for virtual manufacturing. It enables intuitive assembly sequences which are then evaluated by Vizard inspector module. Application/Improvement: In this paper fixture assembly sequences are simulated using VIZARD software. Future research will investigate the fixture assembly plan in a complex virtual manufacturing environment.
Effect of essential oils from Eucalyptus on the growth of aflatoxigenic species.

In Brazil, Eucalyptus species has been cultivated as source of energy and cellulose. They represent the most important cultivated forest in the country. In production areas, the leaves from the trees decay on the soil as green fertilizer. In this study were evaluated pure and blends of essential oils from different species of eucalyptus trees grown in Brazil for antifungal activity against aflatoxigenic species Aspergillus flavus and A. parasiticus . These fungal species can grow and contaminate grains during the storage period under high r.h. conditions, with an eventual production of aflatoxins. Antifungal activity was evaluated by the radial growth measurement of the fungi inoculated on maize meal extract agar basic medium. The eucalyptus oils were evaluated in a contact assay and a fumigant assay using pure and blended oils. Six concentrations of pure and blended oils were evaluated at the following doses: 0, 2, 4, 16, 32 and 84 μL per 20 mL of fungi culture medium. Fungal inocula from conidia suspensions containing 106 spores/mL was inoculated by a needle. Glass Petri dishes were incubated for 9 days at 28°C (± 0.3°C) in the dark. Antifungal activity was observed in all pure and blended oils, in different concentrations of contact and fumigant assay, for both fungi. Eucalyptus stageiriana oil and E. stageiriana + the hybrid E. grandis x E. urophylla oils blend controlled the total fungal growth at the lowest dose (20 μL). Keywords : Essential oil; Eucalyptus spp.; Aspergillus flavus; Aspergillus parasiticus ; Antifungal activity.
Role of denileukin diftitox in the treatment of persistent or recurrent cutaneous T-cell lymphoma

Role of denileukin diftitox in the treatment of persistent or recurrent cutaneous T-cell lymphoma Frederick Lansigan1, Diane M Stearns1, Francine Foss21Hematology/Oncology, Norris Cotton Cancer Center, Dartmouth Hitchcock Medical Center, Lebanon, NH, USA; 2Yale Comprehensive Cancer Center, Yale University School of Medicine, New Haven, CT, USAAbstract: Denileukin diftitox (Ontak&reg;) is indicated for the treatment of patients with persistent or recurrent cutaneous T-cell lymphoma (CTCL), a rare lymphoproliferative disorder of the skin. Denileukin diftitox was the first fusion protein toxin approved for the treatment of a human disease. This fusion protein toxin combines the IL2 protein with diphtheria toxin, and targets the CD25 subunit of the IL2 receptor, resulting in the unique delivery of a cytocidal agent to CD-25 bearing T-cells. Historically, immunotherapy targeting malignant T-cells including monoclonal antibodies has been largely ineffective as cytocidal agents compared to immunotherapy directed against B-cells such as rituximab. This review will summarize the development of denileukin diftitox, its proposed mechanism of action, the pivotal clinical trials that led to its FDA approval, the improvements in quality of life, and the common toxicities experienced during the treatment of patients with CTCL. CTCL is often a chronic progressive lymphoma requiring the sequential use of treatments such as retinoids, traditional chemotherapy, or biological response modifiers. The incorporation of the immunotoxin denileukin diftitox into the sequential or combinatorial treatment of CTCL will also be addressed.Keywords: denileukin diftitox, cutaneous T-cell lymphoma, fusion protein toxin
The influence of an online auction’s product price and e-retailer reputation on consumers’ perception, attitude, and behavioral intention

Online auctions combine the conventional auction model with information technology. However, information asymmetry within such auctions causes risks and uncertainties that influence consumer purchase intentions. In this study, a 2 (product price: high vs. low) × 2 (e-retailer reputation: high vs. low) experimental design was used to understand whether the product price and e-retailer reputation will influence consumers' perceived risk, attitude toward the website and purchase intention. The results of this study indicate that perceived risk negatively influences consumer attitude toward the website and online purchase intention, while consumer attitude toward the website positively influences purchase intention. Moreover, involvement moderates the influence of product price and e-retailer reputation only on social risk but does not have a significant effect on consumer attitude toward the website. This study contributes to a more comprehensive understanding of online auction users' behavior. Finally, the managerial implications, limitations and future research directions are also provided.
INNOVATION DANS LES PROCÉDÉS D’USINAGE DES DIAMÈTRES INTÉRIEURS

BENCIVENNI IVO E FIGLIO SRL ET UNE ENTREPRISE HISTORIQUE DU TISSU RÉGIONAL, DANS LE DOMAINE DE LA TRANSFORMATION MÉCANIQUE, QUI A TOUJOURS SOUTENU ET SOUTENU SON SAVOIR-FAIRE, ÉGALEMENT DANS LE RENOUVELLEMENT GÉNÉRATIONNEL, GRÂCE À DES INVESTISSEMENTS STRATÉGIQUES.
PERIPROSTHETIC BONE PLATES

The present disclosure relates to bone plates that are configured for use with bones having periprosthetic fractures. For example, in the event that a proximal femur is fractured in an area that is adjacent to a prosthetic component, such as a femoral stem used in a hip replacement, the periprosthetic bone plates of the present invention may be used. In one exemplary embodiment, the periprosthetic bone plates include a periprosthetic zone having a plurality of central apertures and a plurality of outer apertures that are offset from the central apertures. The periprosthetic zone may further include a plurality of indentations, each indentation extending longitudinally between adjacent outer apertures to narrow a width of the bone plate.