SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Trace amine-associated receptor 1 (taar1) agonists in a chemogenetic/molecular imaging model of increased dopamine synthesis capacity (ki)

My research plan aims at generating an innovative chemogenetic/positron emission tomography (PET) imaging translational model of striatal dopamine (DA) over-reactivity, the most well-established pathophysiological mechanism underlying schizophrenia. I will use this platform to test the therapeutic efficacy of antipsychotic compounds with a totally new mechanism of action, i.e. targeting the trace amine-associated receptor 1 (TAAR1). Pre-clinical findings will have immediate translation to humans. I envisage a two-fold utility of this platform for the scientific community: 1) development of innovative therapeutic strategies for psychotic disorders; 2) ask fundamental questions about the pathophysiology of schizophrenia. 
A substantial share of patients treated with available antipsychotics do not respond and/or experience undesirable side effects. Available antipsychotics do not target the neurobiological mechanisms underlying schizophrenia symptoms, i.e., increased pre-synaptic DA synthesis capacity (Ki) in the striatum. They rather rely on blockade of DA receptors post-synaptically, possibly causing iatrogenic DA super-sensitivity. Therefore, there is a quest for improved therapeutic strategies, addressing DA over-reactivity. A novel target is represented by TAAR1, a G protein-coupled receptor that has been found to crosstalk with the DAergic system. Based on these premises, the objectives of this project are: 
-Work package 1. To develop a chemogenetic translational mouse model of increased striatal Ki. We will use [18F]-FDOPA PET imaging to determine if selective manipulation of midbrain neuron firing increases Ki.
-Work package 2. To determine if TAAR1 agonists (TAAR1 toolbox) decrease striatal Ki in the model from WP1. We will ascertain whether TAAR1 is necessary for the effect on Ki, using TAAR1 knock-out (KO) mice. 
-Work package 3. To determine whether TAAR1 toolbox modulate Ki in patients with a diagnosis of schizophrenia, applying [18F]-FDOPA PET imaging.
Fracture and mechanical properties of friction stir spot welds in 6063-T6 aluminum alloy

The influence of the tool dimensions and of the welding parameters on the fracture and lap shear properties of friction stir spot welds is investigated. Interrupted lap shear tests allow to follow the mechanisms leading to weld fracture. A triangular cavity opens at the hook during lap shear testing. The distance between this triangular cavity and the hole left by the pin is the main parameter controlling the type of fracture. A too short distance favors a fracture through the weld nugget and hence should be avoided. In particular, this happens when the tool pin diameter is too small and when the plunge rate is too large. Fracture initiating at the triangular cavity and following the thermomechanically affected zone, i.e., by the pullout of the weld nugget, is preferred. This fracture type leads to significant plastic deformation and generally favors a large ultimate force during lap shear testing. Large ultimate forces are observed when the welds are cooler (large plunge rates and low rotation speeds), but the welding conditions should be chosen so as not to lead to fracture trough the weld nugget.
The road to achieving the long-term Paris targets: energy transition and the role of direct air capture

In this paper, we quantify the energy transition and economic consequences of the long-term targets from the Paris agreement, with a particular focus on the targets of limiting global warming by the end of the century to 2 and 1.5 °C. The study assumes early actions and quantifies the market penetration of low carbon technologies, the emission pathways and the economic costs for an efficient reduction of greenhouse gas (GHG) emissions such that the temperature limit is not exceeded. We evaluate the potential role of direct air capture (DAC) and its impact on policy costs and energy consumption. DAC is a technology that removes emissions directly from the atmosphere contributing to negative carbon emissions. We find that, with our modelling assumptions, limiting global temperature to 1.5 °C is only possible when using DAC. Our results show that the DAC technology can play an important role in realising deep decarbonisation goals and in the reduction of regional and global mitigation costs with stringent targets. DAC acts a substitute to Bio-Energy with Carbon Capture and Storage (BECCS) in the stringent scenarios. For this analysis, we use the model MERGE-ETL, a technology-rich integrated assessment model with endogenous learning.
Globalization and the Work of Fashion in Early Modern German Letters

As historians of the material cultures of Italy, England, India, China, and the Americas continue to reconstruct the early modern overseas trade in fashionable commodities, economic historians increasingly urge the study of early modern (or first-wave) globalism. Drawing on insights from this vast body of work, this essay explores the German Alamode discourse of the seventeenth and early eighteenth centuries. Long a stepchild of national literatures, the Alamode discourse across European vernaculars offers a locus of remarkable critical potential, serving to illustrate how global energies shaped local, even apparently provincial, discussions. Via readings of widely circulated and translated illustrated broadsheets, satirical pamphlets, prosodies, and poetry (by Balde, Zesen, Lauremberg, and Logau), this essay also examines the strategies early modern German literati developed to tame the anxieties unleashed when the world arrived at home. Globalization was imagined to work foremost on women, and the backlash it engendered sought to refashion women’s “hard heads,” hammering out “fashionable” notions such as women’s intellectual and literary abilities.
Development of sustainable biogas strategies for integrated agroindustrial waste management

 The objective of the proposed BioGAIA project is to increase the biogas productivity in AD plants that normally treat mixtures of wastewaters based on their seasonal availability and thus operate for periods with mono-substrates, e.g. cheese whey in Italy or cow manure in Greece during summer, to co-digest other agroindustrial wastes or agro-residues available in the area in order not only to operate efficiently but at the maximum of their operational capacity throughout the year.
Therefore, the BioGAIA project targets to increase the sustainability of such AD plants and convert them from waste treatment plants into biogas (bioenergy) production plants attractive for green entrepreneurs by efficiently combining the most appropriate agroindustrial wastes (of liquid or solid form) that are available in each partner area. The goal is dual in this cross-border joint action: protect the environment using AD while, at the same time, exploit the wastes’ energy content and the constructed plants in the most efficient and productive way in terms of energy (both electrical and thermal) and material production (digestate to be used as fertilizer).
Health Promotion in Kenya

This article presents a case study describing how nurses can improve the health behaviors of people living in developing countries. Difficulties and potential solutions are presented. Health promotion allows people to exert control over their health to improve it. A primary difficulty of health promotion in developing countries is communication between care providers and patients. One solution is the utilization of an interpreter; however, in the present study, no professional interpreters were available, thereby complicating the comprehension of new health-related concepts. Another challenge is to understand the patients' perspectives as related to healthcare values. Additionally, as a result of a dearth of evidence-based research in developing countries, difficulties arise in implementing, assessing, and evaluating health promotion programs. Despite these obstacles, nurses continue to travel to developing countries to promote health. Recommendations include respect for a community's health values and incorporation of these values into healthcare planning. To be accepted as a teacher by the local population, the nurse must be able to set aside his/her personal beliefs relating to healthcare, well-being, and disease. Health promotion initiatives should include the means for implementation, thereby enabling the local population to develop skills that will allow them to carry out health promotion projects.
Decreasing Aerosol Loading in the North American Monsoon Region

We examine the spatio-temporal variability of aerosol loading in the recent decade (2005-2014) over the North American Monsoon (NAM) region. Emerging patterns are characterized using aerosol optical depth (AOD) retrievals from the NASA Terra/Moderate Resolution Imaging Spectroradiometer (MODIS) instrument along with a suite of satellite retrievals of atmospheric and land-surface properties. We selected 20 aerosol hotspots and classified them into fire, anthropogenic, dust, and NAM alley clusters based on the dominant driver influencing aerosol variability. We then analyzed multivariate statistics of associated anomalies during pre-, monsoon, and post-monsoon periods. Our results show a decrease in aerosol loading for the entire NAM region, confirming previous reports of a declining AOD trend over the continental United States. This is evident during pre-monsoon and monsoon for fire and anthropogenic clusters, which are associated with a decrease in the lower and upper quartile of fire counts and carbon monoxide, respectively. The overall pattern is obfuscated in the NAM alley, especially during monsoon and post-monsoon seasons. While the NAM alley is mostly affected by monsoon precipitation, the frequent occurrence of dust storms in the area modulates this trend. We find that aerosol loading in the dust cluster is associated with observed vegetation index and has only slightly decreased in the recent decade.
Neoadjuvant and adjuvant chemotherapy with high-dose ifosfamide, doxorubicin, cisplatin and high-dose methotrexate in non-metastatic osteosarcoma of the extremities: a phase II trial in Japan

From 1997 to 2003, 40 patients (all <40 years of age) with non-metastatic osteosarcoma of the extremities were treated with OOS-D and definitive surgery. Two cycles of doxorubicin 90 mg/m(2) plus cisplatin 120 mg/m(2) and ifosfamide 15 g/m(2) were given as neoadjuvant chemotherapy, and two cycles of doxorubicin/cisplatin and ifosfamide, and two cycles of high-dose methotrexate (10-12 g/m(2)) were given post-operatively. All patients underwent limb salvage surgeries, and 66% showed good response to neoadjuvant chemotherapy. With a median follow-up period of 117 months, 31 of the evaluable 40 patients were continuously disease-free, 7 were currently alive with no evidence of disease, and 2 died of disease. There was no local recurrence. The 5-year event-free and overall survival rates were 83 and 98%, respectively. The 10-year event-free and overall survival rates were 80 and 95%, respectively. The major form of toxicity was haematological one.
Information technologies for shift to rail

The IT²RAIL -“Information Technologies for Shift to rail” proposal, first step towards the long term IP4 -“IT for an Attractive Railway” SHIFT²RAIL Innovation Programme, aims at providing a new seamless travel experience, giving access to a complete multimodal travel offer which connects the first and last mile to long distance journeys.
This is achieved through the introduction of a ground breaking Technical Enabler based on two concepts:
• the traveler is placed at the heart of innovative solutions, accessing all multimodal travel services (shopping, ticketing, and tracking) through its travel-companion.
• An open published framework is providing full interoperability whilst limiting impacts on existing systems, without prerequisites for centralized standardization. 
This Technical Enabler will be completely settled in the context of the SHIFT²RAIL IP4, and IT²RAIL is proposing a reduced approach to the scale of a specified use case without weakening any of the key concepts of IP4, such as the usage of Semantic Web technologies, meta planning on distributed data, travel companion with a protected and secured personal wallet stored in the cloud and including the rights to travel. 
The use case will be defined as a specific instantiation of our open concepts, and will benefit from a completely scalable architecture fully instantiated in IP4. 
This approach is addressing all the key challenges of the work program, supporting a complete door-to- door intermodal travel offer and proposing a seamless integration of the very diverse existing and future services for planning, one-stop-shop ticketing, and real-time re-accommodation.
Moreover, thanks to an Interoperability framework which insulates travel applications from the standards fragmentation in multimodal transport, IT²RAIL liberates business-model innovations in the market-place, guaranteeing the economic self-sustainability of these e-services in the long-term.
Legislating home : the impact of the regulation of small house settings for long term care residents in Nova Scotia, Canada

In May 2006, the Province of Nova Scotia, Canada announced a Continuing Care Strategy (CCS)
in which issues of home care and long term care were addressed. The strategy is a 10-year plan
to enhance and expand Nova Scotia’s continuing care system. The CCS covers issues which
include home health care, adult day support, respite care, improved access to services, as well as
funds to build 1320 new long term care (LTC) beds. As a result of the CCS, the Provincial
government has built 11 new LTC facilities to support the vision of “living well in a place you
can call home” (CCS, 2006). A key feature within the guidelines is that all of the new LTC
facilities be built in the model of the small house (SH) community, with multiple households
(cottages) of 12-15 residents each. Each cottage is required to have a living room, dining room,
residentially scaled kitchen, and private bedrooms. In addition, implementation of person
centered care in which residents are given choices in the daily activities is an operational
requirement in the new facilities. In order to gain a better understanding of the implications of a
LTC system where resident choice and empowerment are provided for and regulated by
legislated policy, a qualitative case study was conducted in early 2012 in two LTC facilities in
Nova Scotia. The first facility was designed and built prior to the 2006 CCS regulations (n=48).
The second facility opened in 2009 as one of the first in the Province to be built to the new
guidelines (n=49). Observations took place for eight weeks at both facilities and interviews were
conducted with residents, family members, staff, providers, and legislators. Through place theory
and an ecological theoretical framework, key themes emerged relating to the philosophy behind
the SH model of care which include the need for shared goals, expectations and consistency in
leadership; frontline staff empowerment through the strength of teamwork; and the balance of
choice, risk and autonomy for residents in the setting. The physical environment had a direct
impact on the social environment in the communities and while the actuality of ‘home’ was a
very personal distinction based on the history and past preferences of each individual, the shared
themes between the two study communities were related to the core elements of LTC: the need
for and the provision of care.
Compressor having discharge valve means adapted to enhance the coefficient of performance of the compressor

A cylinder has at least one valve seating surface-forming portion which has an outer surface formed therein with at least one recess, the bottom surface of which serves as a valve seating surface. A discharge valve is arranged on the valve seating surface-forming portion to close or open outlet holes each formed in corresponding ones of the valve seating surface. The discharge valve has at least one valve body formed of an elastic plate member disposed in close contact with a corresponding one of the valve seating surface. Preferably, the valve seating surface is arcuately concavely curved and the corresponding valve body has a correspondingly curved surface. The outlet holes are each formed in a thinnest portion of the valve seating surface-forming portion.
METHODS OF NEUTRALIZING VIRAL INFECTION

Isolated, antigenic polypeptides including a pre-hairpin intermediate conformation of gp41 and vectors encoding such polypeptides are provided. Antibodies that bind to a pre-hairpin intermediate conformation of gp41 and methods of making antibodies a that bind to pre-hairpin intermediate conformation of gp41 are also provided. Vaccines against a pre-hairpin intermediate conformation of gp41, as well as methods of treating subjects infected with HIV, preventing HIV infection, and inhibiting HIV-mediated activities are also provided. Methods of screening compounds that bind to an isolated, pre-hairpin intermediate conformation of gp41 are further provided.
Clothing, Society and Culture in Nineteenth-Century England

Recently, the history of clothing has been the subject of intense scholarly interest, but there has been a shortage of source material available. This three-volume collection redresses the balance, bringing together rare documents and unpublished manuscript material in both reset and facsimile form. The volumes cover the economics of buying and selling clothes, the art of dressmaking and its democratization and issues specific to working class dress during the Victorian and Edwardian periods.

Volume 1 examines clothing from a commercial perspective and contains material from retailers’ catalogues, advertizements, pricelists, posters and dressmakers’ manuals. Illustrations are reproduced in facsimile while print material is presented in reset format. Volume 2 concentrates on changing social attitudes and dress reform, including a series of articles by or about Oscar Wilde. Other sources come from a variety of newspaper and magazine articles, extracts from books and the lyrics of comic songs. Volume 3 looks at the problems and solutions which were faced by the working class in their consumption of clothing. Various perspectives are examined through Parish newsletters and reports, as well as other local and national sources, to produce a picture of hardship and deprivation tempered with charity and ingenuity.
N-gram support vector machines for scalable procedure and diagnosis classification, with applications to clinical free text data from the intensive care unit

Background Existing risk adjustment models for intensive care unit (ICU) outcomes rely on manual abstraction of patient-level predictors from medical charts. Developing an automated method for abstracting these data from free text might reduce cost and data collection times.

Objective To develop a support vector machine (SVM) classifier capable of identifying a range of procedures and diagnoses in ICU clinical notes for use in risk adjustment.

Materials and methods We selected notes from 2001–2008 for 4191 neonatal ICU (NICU) and 2198 adult ICU patients from the MIMIC-II database from the Beth Israel Deaconess Medical Center. Using these notes, we developed an implementation of the SVM classifier to identify procedures (mechanical ventilation and phototherapy in NICU notes) and diagnoses (jaundice in NICU and intracranial hemorrhage (ICH) in adult ICU). On the jaundice classification task, we also compared classifier performance using n-gram features to unigrams with application of a negation algorithm (NegEx).

Results Our classifier accurately identified mechanical ventilation (accuracy=0.982, F1=0.954) and phototherapy use (accuracy=0.940, F1=0.912), as well as jaundice (accuracy=0.898, F1=0.884) and ICH diagnoses (accuracy=0.938, F1=0.943). Including bigram features improved performance on the jaundice (accuracy=0.898 vs 0.865) and ICH (0.938 vs 0.927) tasks, and outperformed NegEx-derived unigram features (accuracy=0.898 vs 0.863) on the jaundice task.

Discussion Overall, a classifier using n-gram support vectors displayed excellent performance characteristics. The classifier generalizes to diverse patient populations, diagnoses, and procedures.

Conclusions SVM-based classifiers can accurately identify procedure status and diagnoses among ICU patients, and including n-gram features improves performance, compared to existing methods.
Effect of solution and post-mortem time on mechanical and histological properties of liver during cold preservation

In this study, we examine the mechanical and histological properties of the bovine liver tissue stored in Lactated Ringers (control), HTK and UW solutions as a function of preservation period. The mechanical experiments are conducted with a shear rheometer on cylindrical tissue samples extracted from 3 bovine livers and the change in viscoelastic material properties of the bovine liver is characterized using the fractional derivative Kelvin-Voigt Model. Also, the histological examinations are performed on the same liver samples under a light microscope. The results show that the preservation solution and period have a significant effect on the mechanical and histological properties of the liver tissue.
Feasibility of selko ai

SelkoAI is the world’s first AI for engineering making your engineering team’s unique expertise scalable across massive engineering projects.

All technology, especially complex projects, is based on written technical specification documents. Processing these documents requires months of high-level expert team work in companies per project, and costs up to hundreds of thousands of euros. 

SelkoAI is the first productized deep learning solution allowing engineers to train their own expert AI for technical text analysis, delivering 10X efficiency increase in simplifying project specifications in large-scale engineering projects. 

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Institutionalized Organizational Learning and Strategic Renewal

Strategic renewal depends on achieving an appropriate balance between using what an organization has learned and continuing to gain new insights and solutions. The process of institutionalizing organizational learning is at the center of this tension since it occurs at the pivot point of exploitation and exploration. We apply a dynamic perspective of Perrow’s typology of work technologies to explore the relation between the number of exceptions and analyzability of the problems likely to be encountered in various work settings and institutionalized learning. We propose that the nature of what is learned and actions leading to institutionalization differ across work contexts because of the varying complexity of problems and solutions. We explore the interactions surrounding institutionalized learning, exploration, and exploitation and argue that strategic renewal is strongly influenced by the way institutionalized learning effects the dynamic tension between exploration and exploitation.