SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Redistribution of knee stress using laterally wedged insole intervention: Finite element analysis of knee–ankle–foot complex

Laterally wedged insoles are widely applied in the conservative treatment for medial knee osteoarthritis. Experimental studies have been conducted to understand the effectiveness of such an orthotic intervention. However, the information was limited to the joint external loading such as knee adduction moment. The internal stress distribution is difficult to be obtained from in vivo experiment alone. Thus, a three-dimensional finite element model of the human knee-ankle-foot complex, together with orthosis, was developed in this study and used to investigate the redistribution of knee stress using laterally wedged insole intervention.Laterally wedged insoles with wedge angles of 0, 5, and 10° were fabricated for intervention. The subject-specific geometry of the lower extremity with details was characterized in the reconstruction of MR images. Motion analysis data and muscle forces were input to drive the model. The established finite element model was employed to investigate the loading responses of tibiofemoral articulation in three wedge angle conditions during simulated walking stance phase.With either of the 5° or 10° laterally wedged insole, significant decreases in von Mises stress and contact force at the medial femur cartilage region and the medial meniscus were predicted comparing with the 0° insole.The diminished stress and contact force at the medial compartment of the knee joint demonstrate the immediate effect of the laterally wedged insoles. The intervention may contribute to medial knee osteoarthritis rehabilitation.
Ultrabright turn-on fluorescent organic nanoparticles for amplified molecular sensing in living cells

Existing fluorescent molecular probes, due to limited brightness, do not allow imaging individual biomolecules directly in living cells, whereas bright fluorescent nanoparticles are unable to respond to single molecular stimuli and their inorganic core is not biodegradable. The aim of BrightSens is to develop ultrabright fluorescent organic nanoparticles (FONs) capable to convert single molecular stimuli into collective turn-on response of >100 encapsulated dyes, and to apply them in amplified molecular sensing of specific targets at the cell surface (receptors) and in the cytosol (mRNA). The project is composed of three work packages. (1) Synthesis of FONs: Dye-doped polymer and micellar FONs will be obtained by self-assembly. Molecular design of dyes and the use of bulky hydrophobic counterions will enable precise control of dyes organization inside FONs, which will resolve the fundamental problems of self-quenching and cooperative on/off switching in dye ensembles. (2) Synthesis of nanoprobes: Using cooperative Forster Resonance Energy Transfer from FONs to originally designed acceptor-sensor unit, we propose synthesis of the first nanoprobes that (a) undergo complete turn-on or colour switch in response to single molecular targets and (b) harvest light energy into photochemical disruption of cell membrane barriers. (3) Cellular applications: The obtained nanoprobes will be applied in 2D and 3D cultures of cancer cells for background-free single-molecule detection of membrane receptors and intracellular mRNA, which are important markers of cancer and apoptosis. An original concept of amplified photochemical internalization is proposed to trigger by light entry of nanoprobes into the cytosol. This high-risk/high-gain multidisciplinary project will result in new organic nanomaterials with unique photophysical properties that will enable visualization of biomolecules at work in living cells with expected impact on cancer research.
Content Driven Profile Matching across Online Social Networks

Many publications deal with profile matching across online social networks and the approaches become increasingly complex. Almost all of them rely on common profile attributes like names and hobbies or structural attributes like relations to other user profiles. These approaches require high effort concerning computation, because each profile of one network has to be compared to all profiles of the other network. Complex approaches are not well suited to handle large datasets. Therefore, we present an approach to significantly reduce complexity by exploiting special properties of dataset IDs. We provide a proof of concept by an implementation of the use case of matching user profiles accross Twitter and Instagram. Additionally to the complexity problem of existing approaches, many profiles with similar attributes often lead to a restrictive trade-off between precision and recall of the matching strategy. Furthermore, profile attributes and relationships are not trustworthy, as these are due to arbitrary change by profile owners. In contrast to most existing approaches that rely on user definable attributes, we rather focus on timing properties of user publications across social media platforms. There are already profile matching approaches based on timing patterns. However, these do not aim to reduce complexity, what is a necessary requirement to be applicable to real-world online social networks. As we will show, the approach can be easily transferred to other networks.
Diálogos críticos y perspectivas actuales de investigación y pensamiento sobre comunicación en Latinoamérica en el 50 aniversario de Chasqui

A partir de la década de los años sesenta del siglo pasado se ha ido dando en Latinoamérica un conjunto de iniciativas investigativas orientado a constituir una escuela crítica de estudios de la comunicación. En un sentido amplio se pueden identificar estas experiencias como antecedentes relevantes de la rica discusión en materia de un nuevo orden mundial de la información y comunicación que se diera desde la mitad de los setenta hasta la mitad de los ochenta. Los aportes significativos de Luis Ramiro Beltrán, sus lúcidos análisis tendientes a desnudar la dominación mediática de agencias de información y medios norteamericanos, presente en la mayoría del panorama mediático latinoamericano, fueron un aliciente para las reflexiones dentro de UNESCO, que la condujo a convencerse de la necesidad histórica de modificar las condiciones desiguales que definían a la comunicación mundial. Fueron sin duda alguna, años en los que Latinoamérica cobraba un lugar importantísimo en el campo de los estudios de la comunicación, con una perspectiva no solo original desde el punto de vista académico o investigativo sino de alcance político, que contribuía a mostrar la necesidad de desentrañar la compleja articulación entre comunicación y poder.
A survey of contraceptive use and unplanned pregnancy in Perth, Western Australia

Abstract: Contraceptive use and unplanned pregnancy were studied in a stratified cluster sample of 1 511 couples with women aged 16 to 44 years resident in metropolitan Perth in 1988. Twenty-one couples were excluded from analysis owing to missing data. The proportion of couples using contraception was 76.8 per cent (1 144 of 1 490), and all but three of the remaining couples gave a reason for nonuse. Among users, surgical sterilisation made up 42.3 per cent (484 of 1 144) of all methods, with a slight predominance of tubal ligation over vasectomy. Oral contraceptives accounted for just over half of nonsurgical methods. Comparisons with a Victorian survey performed in 1978 suggested that surgical methods and condom use may have increased, whereas use of oral contraceptives and intrauterine devices may have fallen. Unplanned pregnancies conceived during the 12 months before the interview affected 3.4 percent (51 of 1 490) of respondents. The incidence of unplanned pregnancy was four times higher in couples with inconsistent usage patterns of contraception.
Supporting cyberinsurance from a  behavioural choice perspective

CYBECO will research, develop, demonstrate, evaluate and exploit a new framework for managing cybersecurity risks, one that is focusing on cyberinsurance, as key risk management treatment. CYBECO integrates multidisciplinary research methods from Behavioural Economics, Statistics, Game and Decision Theory, Security Engineering and Behavioral Psychology in order to develop new concepts and models that are combined within a prototype software architecture (CYBECO Toolbox 2.0). CYBECO recognizes that the cyberinsurance domain is not adequately developed, partly due to the lack of sufficiently large statistical data sample and partly due to the difficulties customers face when deciding on their cyberinsurance investment options. CYBECO will address both these barriers, aiming at delivering advances clearly positioned beyond the State-of-the-Art. We plan to implement a prototype tool that will demonstrate and promote the CYBECO model and concepts. We then foresee to perform behavioural experiments to validate current institutional cybersecurity frameworks and to provide relevant policy insights, particularly in reference to behavioural nudges in cybersecurity. The CYBECO consortium is composed by complementary partners, coming from the addressed research, technological and market domains, that have a proven track record of high quality research capacity. Thus, the carefully structured workplan, embodies a holistic approach towards meeting the CYBECO objectives and delivering market-relevant outcomes of significant exploitation potential.
Legislations to Cope with Climate Change:A Comparative Study and its Enlightenment to China

It has entered a crucial period to address climate change.Different countries promulgate domestic law and relevant specific law to fulfill their commitment pursuant to the common but differentiated responsibility,which proposed in United Nations Framework Convention on Climate Change and Kyoto Protocol.Their experience in legislation showed that there is no direct relationship between specific lawmaking and the camp a country belongs to or the condition of legal system in that country.On the contrary,it has been strongly connected to the international obligation,the suffering from climate change,the attitude to respond such challenge.There is no specific law in this area in China.While it is indispensable for several concerns,the author believed that to make Climate Change Act by drawing lessons on the experience of other countries as well as involving Chinese characteristics is the best choice for China.
Strategies for the Hyperpolarization of Acetonitrile and Related Ligands by SABRE

We report on a strategy for using SABRE (signal amplification by reversible exchange) for polarizing (1)H and (13)C nuclei of weakly interacting ligands which possess biologically relevant and nonaromatic motifs. We first demonstrate this via the polarization of acetonitrile, using Ir(IMes)(COD)Cl as the catalyst precursor, and confirm that the route to hyperpolarization transfer is via the J-coupling network. We extend this work to the polarization of propionitrile, benzylnitrile, benzonitrile, and trans-3-hexenedinitrile in order to assess its generality. In the (1)H NMR spectrum, the signal for acetonitrile is enhanced 8-fold over its thermal counterpart when [Ir(H)2(IMes)(MeCN)3](+) is the catalyst. Upon addition of pyridine or pyridine-d5, the active catalyst changes to [Ir(H)2(IMes)(py)2(MeCN)](+) and the resulting acetonitrile (1)H signal enhancement increases to 20- and 60-fold, respectively. In (13)C NMR studies, polarization transfers optimally to the quaternary (13)C nucleus of MeCN while the methyl (13)C is hardly polarized. Transfer to (13)C is shown to occur first via the (1)H-(1)H coupling between the hydrides and the methyl protons and then via either the (2)J or (1)J couplings to the respective (13)Cs, of which the (2)J route is more efficient. These experimental results are rationalized through a theoretical treatment which shows excellent agreement with experiment. In the case of MeCN, longitudinal two-spin orders between pairs of (1)H nuclei in the three-spin methyl group are created. Two-spin order states, between the (1)H and (13)C nuclei, are also created, and their existence is confirmed for Me(13)CN in both the (1)H and (13)C NMR spectra using the Only Parahydrogen Spectroscopy protocol.
Comparative Evaluation of MRSA Nasal Colonization Epidemiology in the Urban and Rural Secondary School Community of Kurdistan, Iraq

To study the nasal carriage rate of Staphylococcus aureus (S. aureus) (including methicillin-resistant strains) in secondary school community of the urban and rural districts of the Kurdistan region of Iraq, a cross-sectional population based survey was carried out in the city Duhok and rural areas of Amedya, Akre and Zakho.Nasal swabs were obtained from nostrils of 509 students aged 14-23 years. Resistance to methicillin was assessed by Kirby-Bauer disk diffusion and agar dilution assay. Vancomycin sensitivity was also tested on Muller-Hinton agar.It was found that the frequency of overall S. aureus nasal carriage (SANC) was 17.75% (90/509, CI95, 14.58-21.42%). In urban areas, the carriage rate was 20.59% (49/239, CI95, 15.64-26.29%), whereas it was 15.24% (41/270, CI95, 11.17-20.10%) in rural districts. The frequency of methicillin-resistant S. aureus (MRSA) among the isolated strains was found to be 2.04% (1/49) and 21.95% (9/41) in urban and rural areas respectively. It was found that in urban residents, the odd ratio (OR) of acquiring SANC was 1.44 (CI95, 0.91-2.27%) and risk ratio (RR) was at least 1.35 (CI95, 0.92-1.96%) while OR decreased to 0.12 (CI95, 0.01-0.96%) for MRSA carriage. Hence, the S. aureus carriage rate was higher in urban districts compared to rural areas while more MRSA were found in rural areas compared to urban districts. All studied strains were sensitive to vancomycin.This study provided baseline information for S. aureus nasal colonization in the region. Also, it showed that living in rural areas increased the odds of MRSA colonization. More attention should be paid to control MRSA colonization in rural communities.
Developing the INTERNISA network of synergies to increase the number of digitally skilled women employed in the ENI CBC MED territories via matching demand and supply in the labour market

The territories involved in the ENI CBC Med Programme suffer from high unemployment rate and low participation of women in the labour market. At the same time, job growth is hindered by the low penetration of digital innovation in Mediterranean territories which hampers the capacity of small enterprises to find access to know-how or venture capital for innovation. With the aim of providing training in digital skills to women and know-how about digitalization approaches to businesspeople, INTERNISA will combine training in the digital sector with professional development in the agri-food, textile, tourism and financial sectors. To reach its objective, the project will develop online and offline services addressed to women and employers providing training curricula and personal consulting. Project activities will culminate with interventions related to match-making of labour demand and supply through an online platform and job fairs to foster contacts among job seekers and employers.
討論式教學法的原理和實際操作－以國中三年級歷史科「古文明的誕生」為例

This study is aiming to research the practical implement of discussion method in the history class of junior high school. The study manipulated the example of the instruction of history on the birth of ancient civilization in the third grade of junior high school. It through the teaching process and class records of discussion which is interacted between teacher and students to analyze the influence of history learning attitude and history thinking for students in the class situation of real teaching field. The further discussion that the teacher should notice the discussion skill and discussion content under the manipulation of practical teaching. It is for practical useful for case study of teaching base on the limited of teaching hour at school. The conclusion of this study prove the discussion method of interaction between teacher and students is certainly useful in history class. The students will be inspired the ability of history thinking and the ability of expression the opinion of history events personally through the discussion method of interaction between teacher and students. The students will not be passive under lacking the ability of thinking in history problems to receive the history knowledge from teacher anymore. During the studying process, the times of asking questions and participating discussion were enhanced generally by the calculation of guidance and learning manner from the teacher. Therefore , the teacher can lead the discussion, thinking and building the manner by manipulating the discussion method of interaction between teacher and student for students to own the ability of history thinking. The interaction between teacher and students will let the history meaning and life meaning interact each other, the history will come to the reality meaning closely, it helps the students to get and use the ability of historical thinking in class, it also can utilize on problem solving and personal relationship in daily life.
A team-building, thematically-focused and lean-training summer academy system for young future ict entrepreneurs

An innovative training structure focused on addressing the limited capability of young European ICT future entrepreneurs is needed. This is a challenging task, since existing European ICT entrepreneurship training initiatives are characterised by a general fragmentation and a lack of a ‘learning-by-doing’ training approach. STARTIFY7 is an innovative and ambitious project aiming to go beyond the state-of-the-art and create strong synergies with existing initiatives and projects. It suggests a unique approach to ICT entrepreneurial education for the youth, with the following objectives: 1) Perform a thorough Training Needs Analysis for the future ICT entrepreneurs. 2) Embed a team-building process within a lean-training structure. 3) Establish an effective network of trainers. 4) Create innovative lean-training curricula with thematic ICT focus. 5) Ignite competition and strong synergies with existing initiatives. 6) Disseminate, exploit and ensure long-term sustainability. 
The innovative outcomes of the project are the following: 1) Seven Summer Academies in 7 different European cities within a timeframe of two sequential summers (i.e. 2015 and 2016). 2) Seven lean-training and thematically-focused training curricula, embedding a strong team-building process. 3) An integrated network of trainers focused on hands-on and real-world knowledge transfer. 4) A competition based on the best performing teams after the completion of each round of summer academies. 5) Complement, extend and enrich similar existing actions. 6) A centralized social networking service. 7) ECTS credits provision. 8) An integrated exploitation and sustainability plan with the aim of making STARTIFY7 a long-term viable Summer Academy.
STARTIFY7 will aim for 1.400 applications from potential entrepreneurs, 280 student participants, 90 produced demos, 70 engaged teachers/coaches/mentors, 2 boot-camps with 63 participants, 10 VC/angels investors engaged, and, 16 investment-ready proposals.
Effect of virtualization on the cooling infrastructure's power consumption in enclosed aisle data centers

Enclosed aisle data centers with bypass recirculation have previously been shown to reduce significantly the cooling infrastructure's power consumption compared to a typical open-aisle configuration. Enclosed aisle configurations also facilitate IT load placement through so-called thermally aware, energy-optimized virtualization. The formidable problem of optimal workload placement, which has received increased interest by the IT industry and has been the subject of numerous investigations, becomes much simpler, almost trivial, when the aisles are enclosed. This is because there is no preference among identical servers in an enclosed aisle based on the thermal environment, which will be uniform in this case, making for a wide range of equivalent load placement possibilities within the data center, or at least those racks in the data center that share enclosed cold aisles. However, the reduction in IT load can have a significant impact on the energy consumption of the cooling infrastructure due to the off-design operation of equipment. The work presented in this paper uses an experimentally validated thermo-hydraulic model of the data center's cooling infrastructure, previously developed by the authors, to explore optimization possibilities in air-cooled, enclosed aisle data centers. The model is used to evaluate the total energy consumption of the data center's cooling infrastructure for data centers operated at reduced IT load. The analysis highlights the importance of reducing the total power required for moving the air within the CRACs, the plenum, and the servers, rather than focusing primarily or exclusively on reducing the refrigeration system's power consumption and shows the benefits of bypass recirculation in enclosed aisle configurations. Energy efficient operating strategies for data centers with enclosed aisles are given for a range of IT loads and ambient conditions.
ARYL DIPHOSPHINES AND CATALYSTS CONTAINING THE SAME

The present invention provides novel aryl diphosphines having formula (I) wherein X, Y, R1-18, m, m' and n are defined herein, and which can be complexed with a transition metal to form a novel catalyst useful in such applications as hydroformylation.
Tracking conformational dynamics of cohesin with minflux

The DNA contained in each of our cells has a size of about 2 m and is fitted into the nucleus which is about six orders of magnitude smaller. It is unclear, how this extraordinary compaction is achieved and how the cell can still carry out highly regulated processes like gene expression, DNA replication, and DNA repair in such a dense environment.
Cohesin is a protein that has been shown to play an important part in DNA compaction, especially in sister-chromatid cohesion. Recently, it has been observed that cohesin extrudes loops of DNA to achieve compaction, but how exactly it carries out its function is unknown.
Fluorescence spectroscopy is a powerful tool to investigate conformational dynamics of biomolecules. MINFLUX is a recently developed method which localizes single molecules with a precision of a few nanometers. Here, I propose a new method based on MINFLUX which will allow to track fluorescent labels on large bio-molecular complexes with nanometer spatial and millisecond time resolution. The method will be used to study conformational dynamics of cohesin in vitro and investigate the mechanism of loop extrusion.
A Fast Scalable Implicit Solver with Concentrated Computation for Nonlinear Time-Evolution Problems on Low-Order Unstructured Finite Elements

Many supercomputers are shifting to architectures with low B (byte/s; memory transfer capability) per F (FLOPS capability) ratios. However, utilizing increased F is difficult for applications that inherently require large B. Targeting an implicit unstructured low-order finite-element analysis solver, which typically requires large B, we have developed a concentrated computation algorithm that yields significant performance improvements on low B/F supercomputers. 35.7% peak performance was achieved for a sparse matrix-vector multiplication kernel, and 15.6% peak performance was achieved for the whole solver on the second generation Xeon Phi-based Oakforest-PACS. This is 5.02 times faster than (and 6.90 times the peak performance of) the state-of-the-art solver (the SC14 Gordon Bell finalist solver). On Oakforest-PACS, the proposed solver was approximately 2.42 times faster than the state-of-the-art solver running on the K computer. The proposed approach has implications for systems and applications and is expected to have significant impact on various fields that use finite-element methods for nonlinear time evolution problems.