SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Decrypting mycobacterium cytochrome p450 (cyp) physiological functions by testing hypotheses emitted form large-scale comparative genomics analysis

More than 190 species belong to the Mycobacterium genus. Among those, several are pathogenic to human and animals. The high number of human lives lost and the economic consequences of livestock infection are important incentives in the control and eradication of the responsible organisms. M. tuberculosis, one of the causative agents of tuberculosis (TB), is the most problematic representative: in 2016, 1.7 million deaths worldwide have been attributed to TB. Like for other infectious organisms, antibiotic resistances have appeared in Mycobacterium. Thus, there is a fundamental need to develop new antimycobacterial drugs. The inhibition of enzymes belonging to the Cytochrome P450 (CYP) protein family has been shown to suppresses the growth of several Mycobacterium species, making CYPs targets for drug development. Unfortunately, most CYPs are considered orphan: proteins for which no physiological function is known. The deCrYPtion action aims to define the physiological function of a selected set of mycobacterial CYPs. It will prove determinant in the development of new antibiotics. I will perform a large-scale comparative genomics analysis of the CYPs encoded by Mycobacterium species, in order to define orthologous groups and identify, for each, conserved partners and pathway context. This approach is extremely powerful (even if not frequently used) and allow to propose physiological functions, based on the information obtained. Specific CYPs to be characterized will be selected based on a set of stringent considerations, including their potential as drug targets. A preliminary analysis illustrates the approach that will be used. A combination of complementary biochemical, genetics and physiological experiments will be performed to validate the hypotheses generated. deCrYPtion will be undertaken within the Centre for Cytochrome P450 Biodiversity, under the supervision of Prof Steven Kelly, at Swansea University (Wales, United Kingdom).
A Sustainable Development Model for Green Mountain Areas

Mountain territories are important ecosystems exposed to a series of risks and threats: abandonment, use of inappropriate development models, lack of an integrated sustainable approach, loss of biodiversity and degradation of ecosystems. To meet these challenges a transnational project team consisting of 11 organisations from 9 countries will develop and transfer a Sustainable Development and Management Model which can provide an integrated strategy to enhance the preservation and valorisation of mountain areas. Common work around 3 thematic areas will take place: a) identification of economic activities compatible with sustainable development of mountain territories; b) development of coordinated and integrated policies/management plans; c) methods and strategies for information, training and awareness raising. 4 action phases will be implemented to guarantee concrete results which can be transferred to each partner/territory and beyond: 1) Exchange of information, experiences and the identification of European good practices; 2) Development of a Sustainable Development and Management Model through 3 Working Groups; 3) The drawing up of Management Plans and carrying out of territorial concertation involving decision-makers and economic actors, and; 4) Test & transfer of the Model/Management Plans through e.g. mainstreaming workshops, pilot actions and awareness raising targeting decision-makers, economic actors and the public in general. This will result in a better capacity of decision-makers to coordinate and manage sensitive areas, improved capabilities of economic actors to invest in appropriate economic sectors, public participation through improved awareness of the natural value of the territory and ultimately, territories with enhanced biodiversity and valorisation of natural resources. The project outputs consists, amongst others, of the integrated Sustainable Development and Management Model, 9 Management Plans, an Online Platform and a Mountain Network.
Pre-disaster planning and preparedness: drought and flood forecasting and analysis in Zimbabwe

A situational analysis of future drought and flood impacts in Zimbabwe is outlined in this present study. The assessment under different scenarios is carried out using Aqueduct Global Flood Analyzer in which all the analyses are based on the gross domestic product (GDP), population, and the present and future (2030) urban damage. In this study, to effectively estimate future changes, three scenarios were employed, namely, IPCC Scenario A2, the Representative Concentration Pathways (RCP) scenario which represents climate change, and the Shared Socio-economic Pathways (SSP) scenario which represents socio-economic change. All these scenarios were employed from the Intergovernmental Panel on Climate Change 5th Assessment Report. To determine current mean monthly precipitation, 1981–2010 data were used and Meteonorm V7 software was employed for the generation of the mean monthly precipitation from 2011 to 2100. The level of flood protection employed is a 10-year one which is used to identify the population at risk, the effects of this event on the GDP and to determine the rate at which urban damage is happening. Utilizing Meteonorm V7 software, average monthly precipitation is predicted. This study determined that, in any year, the majority of Zimbabwe has a low to medium (2–3% probability) flood occurrence in which a 10-year flood has a 10% occurrence probability in any given year. If there is no flood protection employed, this 10-year flood could cause around 74.9 million USD affected GDP, 119 thousand affected population and 49.5 million USD urban damage. As much as it is impossible to eliminate drought and flood events, a diminution approach and proper planning and preparation before their occurrence reduce the economic and social losses.
Cp2 is a project to develop a new wrist placement technology that can detect anomalies with both the cardio and vascular systems simultaneously.

Combined Pressure and Cardiac Performance (CP2) is a project that develops a diagnostic device that enables a paradigm shift in physiological performance analysis. CP2 utilises multi-modal sensing to identify both Cardiac Performance as well as Vascular system performance from the subject, in 30 seconds, with the subject remaining clothed. The CP2 system draws on the experience from monitoring high performance engines within the world of F1 motorsport and transfers these techniques into medical care. By using new diagnostic sensing technologies and by analyzing the data for Biomarkers, the project is be able to identify the following disorders of the Cardio-Vascular system. Hypertension, Peripheral Arterial Disease, Aortic Stenosis, Atrial Fibrillation, Atrial Flutter, Ectopic beats, Bradycardia, Tachycardia and Type 1 & 2 Heart Block. The CP2 system works by placing an array of sensors under both wrists, with the subject actively engaged in the process. No straps or restraints are involved, the subject remains in complete control at all times throughout the process and so there is the potential to reduce ""Hypertensive White Coat"" syndrome. The new multimodal sensing system allows both the Vascular and Cardio side of the Heart and Circulatory system to be tested simultaneously and the results from both halves to the equation to be reviewed against each other. The CP2 project thus brings together existing physiological parameters in new forms that should not only allow the identification of known disease, but also might lead to the establishment of biomarkers previously undetected owing to the two systems being operated asynchronously. It is easy to produce a better incarnation of what has gone before, but CP2 seeks to produce a paradigm shift in the usage of medical devices in the proactive screening role. With a screening taking only 30 seconds the opportunity exists to optimise the patient care pathway and to enhance patient flow within Primary Care locations.
ON-PREMISES AND OFF-PREMISES COMMUNICATION

Proposed are concepts for managing communication between off-premises and on-premises servers. A file system event request from an application of a first server (such as an off- premises server or an on-premises server) is received and a requested file system is determined based on the received file system event request. Stored file system path data associated with the requested file system can then be identified. The file system event request is then communicated to a second server (such as an on-premises server or off-premises server) based on the identified file system path data.
Betriebskapital

Das Projekt betrifft die Unterstützung des Betriebskapitals eines Unternehmens im Falle eines Umsatzrückgangs (Umsatzerlöse), der durch die negativen Auswirkungen des COVID-19-Ausbruchs verursacht wird.
Postizanje i održavanje higijenskih uvjeta u instalacijama pitke vode

In this paper satisfactory hygiene conditions for the water supply system are proposed through guidances, specifications and recommendations. In addition to hygienic design of water installations, the thesis provides possibilities for maintaining hygiene. Additionally, impacts on water quality are discussed and microorganisms that can proliferate due to these impacts are described. 
Installation solutions were implemented using the example of an actual object in Dendrit computer program. A pressure drop calculation was performed. The system analysis obtained satisfactory water temperatures, corresponding flow rates, an overview of the system materials and the time required to reach the required water temperature at the point-of-use fittings. A thermal simulation was performed to check temperature drop in the recirculation part of water system.
5-imino-13-deoxy anthracycline derivatives, their uses, and processes for preparing them

5-imino-13-deoxy anthracycline derivatives, medical uses of 5-imino-13-deoxy anthracycline derivatives and methods for preparing 5-imino-13-deoxy anthracycline derivatives.
<b>Höhne, Steffen (Hg.)</b>. <i>Zusammenbruch, Trauma, Triumph. Das Epochenjahr 1918 und sein Nachleben in Zentral-, Ostmittel- und Südosteuropa.</i> Wiesbaden: Harrassowitz Verlag, 2020 (= Ostmitteleuropa interdisziplinär; 2). 386 pp., 12 Abb., 1 Karte.

Article Höhne, Steffen (Hg.). Zusammenbruch, Trauma, Triumph. Das Epochenjahr 1918 und sein Nachleben in Zentral-, Ostmittel- und Südosteuropa. Wiesbaden: Harrassowitz Verlag, 2020 (= Ostmitteleuropa interdisziplinär; 2). 386 pp., 12 Abb., 1 Karte. was published on November 1, 2022 in the journal Kritikon Litterarum (volume 49, issue 3-4).
COOKING APPARATUS

The present disclosure relates to a cooking appliance. In the present disclosure, a cavity (S) may be formed inside the casing (100, 200), and a plurality of heat source modules may be arranged inside the casing (100, 200). Additionally, a distance sensor (710) is disposed on an upper surface of the casing (100, 200) to measure a distance to the food placed inside the cavity (S). In this way, information on the height or thickness of the food may be obtained through the distance sensor (710) disposed in the casing (100, 200), and the distance sensor (710) may ensure an accurate measurement angle at the upper portion of the casing (100, 200).
Smart and sensing robotic system for endovascular interventions with haptic feedback

UAB ""Inovatyvi medicina"" has developed an innovative design of endovascular robotic system HAPGuide. This SMART and SENSING technology allows to perform endovascular procedures without medical personnel being exposed to harmful X-rays. HAPGuide solves the main issues of existing robotic systems and opens up possibilities for safer, faster and more effective endovascular interventions in EU and Worldwide. In comparison to existing systems (with only visual feedback and videogame like control) the main HAPGuide advantage is the haptic feedback and traditional control of endovascular instruments using fine-tuned surgeons’ perception-action-visualization abilities. Future developments involve HAPGuide use in telemedicine and partially automated functions via machine learning. Our system is designed to use all standard endovascular instruments and avoids the need of expensive catheters dedicated for the system. The primary target market of HAPGuide is cath labs performing percutaneous coronary interventions and peripheral vascular procedures in EU and US (more than 5.6 mln. procedures annually). The estimated market potential of HAPGuide robotic system in primary worldwide market exceeds €4 billion. The secondary target market would involve neurointerventional procedures while in the long-run expansion to telerobotics will create new market opportunities. Our revenue model involves four main components: 1) durable robotic HAPGuide system; 2) single use cassette; 3) annual service of the system; 4) HAPLearn training software. A multidisciplinary team with vast experience in medical sciences, medical device development, robotics, mechanical and electronic engineering, product design, commercialisation and business development has joined forces for the implementation of HAPGuide project aiming to bring the technology to clinical practice for benefit of patients, physicians and hospitals and exploit this €4 billion niche market commercial opportunity.
Feasibility study for multicursor - a non-contact sensor for curing quality control

Although manufacturing is moving towards digitalization and full automation, some industries, such as the furniture industry, are still heavily reliant on inefficient and outdated technologies. In particular, the furniture sector has been identified to lack any sort of automated solution for wood curing quality control, one of the critical manufacturing processes. Apart from causing a high defect rate, the absence of an inspection system creates a risk of manufacturing hundreds of thousands of pieces of furniture that are not adequately cured and potentially poisonous. This, in turn, leads to increased health risks and possible legal liabilities for the manufacturing company. To address the challenges, Factobotics, a Lithuanian robotics SME, has developed a novel solution– Multicursor. Multicursor is an intelligent non-contact polymerization quality system combining cutting-edge laser technology and machine learning models to provide a real-time response on wood surfaces curing level and quality. On the contrary to the existing solutions on the market, Multicursor is provided with a non-contact sensor, is easy to integrate into the process of manufacturing through, enabling automated quality control and data collection. Thanks to its competitive advantages the system will make measurement faster and allow zero defect manufacturing through real-time system monitoring and collection of valuable data. Multicursor is currently at TRL 6. The next step is moving on to TRL 7 that will require the introduction of the industry-grade prototype with further testing in the furniture production facilities. To ensure successful commercialization, in Phase 1 of SME Instrument, Factobotics intends to develop an elaborated feasibility study for Multicursor that is to include the finalization of Multicursor’s value proposition, the creation of the Technical Specifications for Artificial Intelligence and development of the Multicursor business plan.
Impact of the severity of chronic periodontal disease on quality of life

We examined the impact of the severity of periodontal disease on quality of life in adults with chronic periodontitis. One hundred patients (age, 30-58 years) who were assisted at the Basic Health Care Unit in the city of Passo Fundo, RS, Brazil underwent clinical examination of all standing teeth, including gingival bleeding on probing, probing depth, and clinical attachment level, and were divided into those with mild/moderate (n = 49; group G1) and severe (n = 51; group G2) chronic periodontitis. The participants were then interviewed, using a structured questionnaire. The Brazilian Oral Health Impact Profile (OHIP-14Br) questionnaire was used to assess oral health-related quality of life. Associations were investigated, and those with a P value of less than 0.2 were tested using multiple logistic regression models. Those with a P value of 0.05 or less were considered significant. There was a significant association between G2 and education level (P = 0.00051). OHIP-14Br score was higher for G2 (24.1) than for G1 (18.2) (P = 0.0455). Severe chronic periodontitis was associated with low education level (≤8 years) (odds ratio [OR], 3.0; 95% confidence interval [CI], 1.2-7.3) and pronunciation difficulties (OR, 3.1; 95% CI, 1.0-9.3). In conclusion, periodontal disease severity was inversely associated with quality of life among Brazilian adults.
Composite fan aerodynamic, aeroelastic, and aeroacoustic validation rig

The main aim of the CA3ViAR project is the design of an Open-Test-Case Fan geometry that will develop instability mechanisms which are representative for UHBR fans of civil aircrafts and perform a comprehensive experimental investigation to measure aerodynamic, aeroelastic and aero-acoustic performance in a wide range of operational conditions. Experimental tests will be performed in the Propulsion-Test-Facility (PTF) of the Institut für Flugantriebe und Strömungsmachinen (IFAS) of Braunschweig, Germany. The proposal CA3ViAR will target several objectives. Initially a literature review of the main issues affecting composite UHBR engine fans will be performed by the Technische Universität Braunschweig (TUBS). The design of the Low-Transonic Fan (LTF) will be led by TUBS with support from DREAM (an Italian SME) in terms of aerodynamic shaping as well as from Leibniz Universität Hannover (LUH) and IBK in terms of aeroelasticity and aeroacoustics. The LTF test article, to be mechanically designed by IBK, will be conceived in a way to experience aerodynamic and aeroelastic instabilities in an expected way during wind-tunnel operations. Manufacturing-related activities will be performed by ADC, a well-recognized manufacturer specialized in aerospace parts and components made of composite and metallic materials, while requirements for the test article integration will be provided by TUBS, responsible of WT instrumentation and operations. The execution of the experimental tests aimed at measuring fan instabilities (e.g. stall, flutter, etc.) will be performed by TUBS with support from LUH. The last technical phase of the project will be the calibration and the eventual validation of aerodynamic, aeroelastic and aeroacoustic models according to WT test data acquired in the PTF. This last technical phase will be led by LUH, with a strong support from all the other partners.
The ∼860 Ma mafic dikes and granitoids from the northern margin of the Yangtze Block, China: A record of oceanic subduction in the early Neoproterozoic

Abstract There are voluminous Neoproterozoic arc-related volcano-sedimentary sequences and small intrusions on the northern margin of the Yangtze Block, South China. The understanding the origin of the Sanligang granitoid intrusion and the spatially associated mafic dikes in the region is crucial for unraveling the tectonic evolution and continental crust growth processes in the Yangtze Block. Zircon U–Pb dating suggests that the mafic dikes (ca. 871 Ma) and granitoids (ca. 860 Ma) are contemporaneous. The mafic dikes have low SiO2 (45.37–46.55 wt.%), K2O (0.32–0.82 wt.%) and Na2O (2.01–2.85 wt.%), and are characterized by enrichment in large ion lithophile elements (LILEs) and depletion in high-field strength elements (HFSEs), suggesting that their mantle source was modified by subducted materials. The Sanligang granitoids have intermediate to high SiO2 (60.35–71.38 wt.%), intermediate K2O (1.38–3.67 wt.%) and Na2O (3.97–5.33 wt.%), and high MgO (1.03–3.16 wt.%). They show LREE-enriched REE patterns (La/YbN = 7.2–12.3) with no or minor negative Eu anomalies. Their primitive mantle-normalized trace element patterns are characterized by enrichment of LILEs and depletion of HFSEs. Both the mafic dikes and granitoids share similar zircon ɛHf(t) values (+10.5 to +12.9, +7.9 to +11.7, respectively), whole-rock initial 87Sr/86Sr ratios (0.7051–0.7057, 0.7033–0.7041, respectively) and ɛNd(t) values (+4.0 to +7.1, +3.4 to +4.9, respectively), suggesting that the granitoids were generated by partial melting of juvenile basaltic crust. High Mg# values (49–58) in the granitoids may have resulted from assimilation of residual mafic minerals in their source region. Based on its arc-related geochemical affinity and contemporaneous arc-related magmatism, the Sanligang pluton is proposed to be generated in a Neoproterozoic arc setting during crustal growth and reworking. The early Neoproterozoic assemblage from the Sangligang–Sanyang fault belt provides an important record of oceanic slab subduction in the northern margin of the Yangtze Block.
Race, Status, and Biodiversity: The Social Climbing of Quinoa

This article investigates the scientific and local knowledge of biodiversity of quinoa in Peru and its association with racialized classification schemes—both for humans and for plants. While race is purportedly used as a classificatory tool, it has a deep history of negative discrimination that transcends application to people and has been applied to other species associated with racialized humans. This article reports compiled data on the nomenclature of quinoa varietals from Andean farmers from the altiplano in Puno, Peru. This research demonstrates that domesticated plants that have deep connections to human diversity and traditional cultures can be racialized. These plants are also critical to the maintenance of biological diversity.
Innovative ice protection and shielding system for hlfc demonstrator

Aircraft manufacturers are continuously seeking for decreasing their CO2 emissions and trying to make flights more efficient and eco friendly. As part of this searching one major warhorse is the drag reduction during flight; One of this systems is the Laminar Flow Control LFC, where Hybrid Laminar Flow Control (HLFC) is included. Classic systems as IPS and shielding systems have to coexist with the new HLFC system in a much reduced allocation space. 

Towards the new generation of more efficient aircraft the use of More Electric Aircraft (MEA) is increasing during the recent years and modern aircrafts such as Airbus A350 and especially Boeing 787 are mounting more electrical systems.

This project faces two challenges. Firstly to develop an electrical harness for power feed and monitoring systems of the HLFC, and secondly to develop an innovative way of carrying electricity in an aircraft to solve the big problem of lack of space in the leading edge where these HLFC systems operate. Regarding the first challenge IcePass proposal includes a detailed study of the new routings, with selection of components, and application of additive manufacturing tecnologies for brackets, in order to fullfill the complex space requirements of HLFC. For the second challenge  IcePass proposes an innovative flat harness concept with application of 3d printing technology which will solve the space problem in the L/E and make possible an HLFC system. Whatismore, IcePass proposes aswell an innovative way of routing harnesses through mechanisms, and particularly for the actuation system, by application of slip rings.

Solving both challenges, IcePass will manage to design and manufacture the electrical system of the HLFC thanks to the application of innovative wiring system concept which will change the state of the art in aerospace industry and manage to achieve the bigger MEA challenge.