SIRIS-Lab/unlabelled-sti-corpus huggingface dataset:
Controlling herpesviruses after allogeneic stem cell transplantation : predictive features of T-cell immunity

Infections with herpesviruses such as cytomegalovirus and Epstein-Barr virus occur often during childhood and have an asymptomatic course. After primary infection, both viruses persist lifelong in the host where there is a tightly regulated balance between virus infected cells and control through cytotoxic T-cell responses. During the immunosuppressed state following allogeneic stem cell transplantation, this balance is disrupted and reactivation of these viruses can lead to serious complications such as post transplant lymphoproliferative disease or CMV disease. This thesis focuses on identifying features of T-cell immunity which can predict adequate, or on the other hand lack of control, of viral reactivations. We investigated the general T-cell reconstitution by looking at both the quantity and quality of the reconstitution as well as the virus specific T-cell reconstitution. We found that measuring T-cell functionality shortly after transplantation is more important in determining adequate T-cell immunity than measuring absolute T-cell numbers. For example, we found an association between early expression of the cytotoxic molecule perforin in CD8+ T cells and subsequent severe viral reactivations. This could therefore provide a new tool for identifying patients at risk of viral complications early after SCT. The studies described in this thesis provide insight in the role of T-cell immunity in onset of viral reactivation after allogeneic stem cell transplantation as well as the role of general and virus specific T-cell reconstitution in reactivation severity
Miniaturitzed coherent soft x-ray source for research and industry

X-rays are a prime analytical tool across a diverse range of areas in our modern economy—from fundamental physics and chemistry research, to the pharmaceutical and semiconductor industries. In particular, sources of ultrafast coherent x-rays are expected to have a transformative impact in all of these areas due to their capacity to enable the study of interactions between charge carriers and atoms in gases, liquids and solids, in real-time, and with element specificity. Ease of use, compactness and price will prove vital for any new X-ray technology looking to find use in industrial applications. “miniX” will address all of these issues with the miniaturization of a laser-based soft x-ray source, designed for lay user operation and at low cost.
ARTICLES OF MANUFACTURE COMPRISING NANOCELLULOSE ELEMENTS

The present invention provides formulations comprising a suspension of nanocellulose (NC) elements and a drying/dispersal additive selected from the group consisting of temperature-responsive polymers, small molecule additives in volatile systems, and blocking agents and methods of preparing such formulations, and further provides NC-containing materials, composite materials and useful articles of manufacture made therefrom.
Estructura de carrocería trasera de vehículo y procedimiento para su fabricación

Una estructura de carrocería trasera de vehículo (2) que comprende un riel trasero (10, 12) que se extiende en una dirección longitudinal y una viga de parachoques trasera (21), que se extiende transversalmente a la dirección longitudinal, teniendo el riel trasero (10,12) un extremo trasero (10a) y un extremo delantero (10b), separados a lo largo de la dirección longitudinal, estando conectado el extremo trasero (10a) a la viga de parachoques trasera (21) y extendiéndose el riel trasero (10, 12) hacia la parte delantera del vehículo desde su extremo trasero (10a), caracterizada porque el riel trasero (10, 12) comprende al menos una porción delantera (37), una porción intermedia (39) y una porción trasera (41), estando destinada la porción delantera (37) a extenderse junto a un depósito de combustible del vehículo, siendo la resistencia a la deformación plástica de la porción delantera (37) mayor que la resistencia a la deformación plástica de la porción intermedia (39), que es en sí misma mayor que la resistencia a la deformación plástica de la porción trasera (41), y porque la estructura de carrocería trasera de vehículo (2) comprende además una estructura de guía (51) destinada a guiar la deformación del riel trasero (10,12) para impedir una deformación del mismo en una dirección perpendicular a la dirección longitudinal.
Larvicidal activity and seasonal variation of Annona muricata (Annonaceae) extract on Plutella xylostella (Lepidoptera: Plutellidae)

The diamondback moth Plutella xylostella is an important pest of cruciferous plants, particularly of cabbage (Brassica oleracea var. acephala). The activity of an ethanolic leaf extract of Annona muricata on the development of the larvae and pupae of a laboratory culture of P. xylostella was evaluated, together with the seasonal variation of this activity. Neonate larvae were fed with kale leaf discs that had been treated by immersion in solutions of A. muricata extracts, and the effects on the duration and viabilities of the larval and pupal phases of the insect were determined. The activities of the extracts varied significantly according to the time of collection of the leaf material and were maximal for leaves collected during the dry period of the year (October-February). At the highest concentration tested (5 mg.ml-1), the most active extract caused 100% larvae mortality; at lower concentrations, the duration of the larval phase was increased by up to 2.6 days and the larvae survival was significantly reduced. The pupal phase was affected far less by exposure to the extracts, although such duration was increased by up to 1 day in the presence of non-lethal concentrations. The significance of these results with respect to the use of extracts of A. muricata for their insecticidal activity is discussed.
Unraveling the molecular dialogue in microbial-assisted plant growth in the presence of heavy metals

Agriculture is currently confronting (i) an increasing human population and (ii) limitations of soil use due to, among other reasons, pollution levels above food safety threshold values. Some agricultural practices increase the heavy metal content (HM) of agricultural soil, representing an important threat for the European agricultural development. The use of microorganisms as plant growth promoters has been increasingly studied for a number of years, but it has only recently been proposed to improve plant metal tolerance. Regrettably, plant-microorganism-pollutant interactions are still poorly understood and the molecular underlying mechanisms are mostly unknown. The abovementioned challenges for agricultural production require the study of these mechanisms to better promote a more efficient and sustainable agriculture. This project will venture into new unchartered territory by focusing on the molecular interactions between a probiotic actinobacterium (Micromonospora cremea) and its host, Pisum sativum (garden pea), in the presence of HMs. We will evaluate the capacity of M. cremea CR30 to improve plant tolerance to HM polluted soils, in addition to unraveling the molecular dialogue during the first and late steps of their interaction. Early step interactions are crucial in plant promotion and protection against external stresses, like pollution by HM. Here, we propose the use of new -omic technologies to study these molecular interactions between plants and microorganisms under metal stress, providing a new pathway for an improved soil management. This project addresses a crucial objective in food security, the development of sustainable agricultural practices to control potentially adverse HM effects on plant health.
OS DONOS DO VOTO: ELEIÇÕES, DINHEIRO, VIOLÊNCIA E DOMINAÇÃO NO BRASIL

O artigo problematiza a noção de patrimonialismo estatal como principal razão explicativa para a dominação no Brasil, como presente em vários autores, com destaque para Faoro (1958, 1974, 2022) e Swartzman (2003, 2007). A partir das pistas teóricas deixadas por Maria Sylvia de Carvalho Franco, o objetivo é a busca de uma interpretação que considere a relação entre dominação, violência e manutenção perene da desigualdade no Brasil no quadro de um capitalismo moderno desde sempre, colocado em comparação com uma interpretação da dominação baseada no patrimonialismo e no atraso. A metodologia analisa documentos da imprensa e do judiciário em torno da crise política brasileira iniciada em 2013, constrói um tipo-ideal e deduz um tipo empírico presente no sistema. A conexão de sentido da dominação brasileira informa uma relação forte entre o operador político nascido do capanga, as eleições, o exercício do poder político e uma criptoplutocracia, presente, ao menos desde o XIX e que deu o tom no sistema político brasileiro sob o manto do financiamento privado das eleições, controlando as riquezas do Brasil nas mãos da plutocracia e perpetuando ignóbeis desigualdades.
A PHARMACEUTICAL COMPOSITION CONTAINING VITAMIN B12

The invention relates to a pharmaceutical composition for intranasal administration for human subjects comprising vitamin B12 and a pharmaceutically acceptable carrier. According to the invention, vitamin B12 particles are dispersed in a hydrophobic continuous phase as the pharmaceutically acceptable carrier. Such a dispersion of solid vitamin B12 particles (crystals or amorphic) in a hydrophobic continuous phase displays very satisfactory bioavailability. Also, the intense red colour is reduced significantly, making the pharmaceutical composition acceptable for intranasal use.
Innovative ground interface concepts for structure protection

IINSPIRE aims to foster a new generation of highly qualified researchers and engineers, which will create a critical mass kernel, able to implement a holistic and novel soil-foundation-structure concept for the efficient protection of structures from all ground induced hazards, including earthquakes and all other sources of low-frequency noise and vibration excitations. This concept offers a drastic breakthrough over the existing approaches in crucial aspects:
A)Wave inhibition capabilities over broadband low-frequency excitation in all three spatial directions 
B)General applicability to broad classes of structures and infrastructures 
C)Simple, reliable and resilient design,  leading to easy and low-cost implementation and maintenance
INSPIRE mainly relies on recent innovative scientific and technological concepts, mainly developed within the broad concept of meta-materials.  The notion of “meta-materials” refers to natural or artificial materials or structures which exhibit extraordinary properties for inhibiting or conditioning wave propagation in all spatial directions over broad frequency bands.  Quite recently, the feasibility of the application of meta-material concepts has been also demonstrated for seismic and infrasound waves. These general developments of metamaterials will be further enriched and advanced through novel absorption and isolation concepts, such as negative effective mass and stiffness
Assigning Web News to Clusters

The Web is overcrowded with news articles, an overwhelming information source both with its amount and diversity. Assigning news articles to similar groups, on the other hand, provides a very powerful data mining and manipulation technique for topic discovery from text documents. In this paper, we are investigating the application of a great spectrum of clustering algorithms, as well as similarity measures, to news articles that originate from the Web and compare their efficiency for use in an online Web news service application. We also examine the effect of preprocessing on clustering. Our experimentation showed that k-means, despite its simplicity, accompanied with preliminary steps for data cleaning and normalizing, gives better aggregate results when it comes to efficiency.
Nanoparticle enhanced molten salts for solar energy storage

Thermal energy storage is a useful method to adjust temporal mismatch between the demand and supply of solar energy systems, and latent thermal energy storage (LTES) using phase change material (PCM) has drawn increasing attentions for its high energy storage density and small temperature variation. Molten salt is a promising candidate for solar energy storage media at middle temperature range (140~300 oC). However, the low thermal conductivity of pure salt hampers the development of this technology. This proposal aims to introduce high conductive nanoparticles (NP) to improve the stability and thermo-physical properties of conventional PCMs for solar energy storage, termed as NPMSSES. Molten salts will be used as the matrix, and NPs (i.e., nickel, graphite platelet nanofibers and graphene) or expanded graphite (EG) will be introduced. It is a highly challenging yet exciting project that unites and advances the boundaries of three state-of-the-art disciplines: functional nanoparticles / nanocomposite, solar energy storage, and multiscale modelling. This work will address four main tasks: i) synthesis and characterization of NP-PCMs with good stability ii) identification thermo-physical properties of NP-PCMs under high temperature; iii) investigating their operational and heat transfer characteristics in a LTES system, including shell-tube and fluidized bed types, and iv) multiscale modeling thermo-physical properties of composite PCMs. My strong experience in experimentation with PCM and heat transfer and the vast knowledge on advanced nanomaterials synthesis and characterisation, and multiscale modelling of the host university will create the optimal environment to deliver the objectives of NPMSSES. The fellowship will be highly beneficial to establish myself as an independent researcher. It is expected that significant innovation should be made in the area of NP-PCM fabrication and mechanistic understanding of heat transfer mechanisms.
iniciativas de verificación y su relación con los medios en los países del sur de Europa.

En los últimos años la proliferación de fake news se ha convertido en un tema habitual y la lucha contra este fenómeno en uno de los principales retos en medios de comunicación, instituciones y gobiernos, sobre todo al hilo de la crisis sanitaria provocada por la Covid-19 en la que la desinformación y el concepto de infodemia han tenido gran protagonismo. La pandemia y las restricciones de movilidad han supuesto un revulsivo para las audiencias televisivas siendo este medio el más utilizado para la informarse. En este sentido, han tomado especial relevancia las estrategias y recursos dedicados por los medios de comunicación a la verificación de datos. Este estudio analiza los sistemas de verificación de los países que conforman el modelo mediterráneo, Portugal, España, Italia y Grecia. Dado el contexto extraordinario que ha supuesto la infodemia originada por la COVID-19 y sus consecuencias en el ecosistema político resulta de interés evaluar qué tratamiento se ha llevado a cabo en los mencionados países debido a sus características mediáticas singulares. El enfoque metodológico eminentemente cualitativo se ha centrado en la revisión de fuentes documentales y en la comprobación empírica de los sistemas de verificación de Portugal, España, Italia y Grecia y cómo estas iniciativas ejecutan la difusión de la información verificada. En total se han identificado 30 iniciativas que responden a estrategias de verificación basadas en recursos humanos, en recursos tecnológicos o mixtas, en XX casos tienen un espacio de emisión propio o sección en medios de comunicación tradicionales, suponiendo estas experiencias una vía de difusión de la información verificada. Se comprueba la hipótesis de partida que sostiene que las iniciativas de verificación de la información son herramientas útiles y necesarias que actualmente no tienen un reflejo efectivo para conectar con las audiencias, si no es a través de la búsqueda activa de los espectadores.
SP-D and regulation of the pulmonary innate immune system in allergic airway changes

The airway mucosal surfaces are constantly exposed to inhaled particles that can be potentially toxic, infectious or allergenic and should elicit inflammatory changes. The proximal and distal air spaces, however, are normally infection and inflammation free due to a specialized interplay between cellular and molecular components of the pulmonary innate immune system. Surfactant protein D (SP-D) is an epithelial-cell-derived immune modulator that belongs to the small family of structurally related Ca(2+)-dependent C-type collagen-like lectins. While collectins can be detected in mucosal surfaces of various organs, SP-A and SP-D (the 'lung collectins') are constitutively expressed in the lung at high concentrations. Both proteins are considered important players of the pulmonary immune responses. Under normal conditions however, SP-A-/- mice display no pathological features in the lung. SP-D-/- mice, on the other hand, show chronic inflammatory alterations indicating a special importance of this molecule in regulating immune homeostasis and the function of the innate immune cells. Recent studies in our laboratory and others implied significant associations between changes in SP-D levels and the presence of airway inflammation both in animal models and patients raising a potential usefulness of this molecule as a disease biomarker. Research on wild-type and mutant recombinant molecules in vivo and in vitro showed that SP-D binds carbohydrates, lipids and nucleic acids with a broad spectrum specificity and initiates phagocytosis of inhaled pathogens as well as apoptotic cells. Investigations on gene-deficient and conditional over expressor mice in addition, provided evidence that SP-D directly modulates macrophage and dendritic cell function as well as T cell-dependent inflammatory events. Thus, SP-D has a unique, dual functional capacity to induce pathogen elimination on the one hand and control of pro-inflammatory mechanisms on the other, suggesting a potential suitability for therapeutic prevention and treatment of chronic airway inflammation without compromising the host defence function of the airways. This paper will review recent findings on the mechanisms of immune-protective function of SP-D in the lung.
Overview of the<i>CCP</i>4 suite and current developments

The CCP4 (Collaborative Computational Project, Number 4) software suite is a collection of programs and associated data and software libraries which can be used for macromolecular structure determination by X-ray crystallography. The suite is designed to be flexible, allowing users a number of methods of achieving their aims. The programs are from a wide variety of sources but are connected by a common infrastructure provided by standard file formats, data objects and graphical interfaces. Structure solution by macromolecular crystallography is becoming increasingly automated and the CCP4 suite includes several automation pipelines. After giving a brief description of the evolution of CCP4 over the last 30 years, an overview of the current suite is given. While detailed descriptions are given in the accompanying articles, here it is shown how the individual programs contribute to a complete software package.
Sequence and analysis of a whole genome from Kuwaiti population subgroup of Persian ancestry

The 1000 Genome project paved the way for sequencing diverse human populations. New genome projects are being established to sequence underrepresented populations helping in understanding human genetic diversity. The Kuwait Genome Project an initiative to sequence individual genomes from the three subgroups of Kuwaiti population namely, Saudi Arabian tribe; "tent-dwelling" Bedouin; and Persian, attributing their ancestry to different regions in Arabian Peninsula and to modern-day Iran (West Asia). These subgroups were in line with settlement history and are confirmed by genetic studies. In this work, we report whole genome sequence of a Kuwaiti native from Persian subgroup at >37X coverage.We document 3,573,824 SNPs, 404,090 insertions/deletions, and 11,138 structural variations. Out of the reported SNPs and indels, 85,939 are novel. We identify 295 'loss-of-function' and 2,314 'deleterious' coding variants, some of which carry homozygous genotypes in the sequenced genome; the associated phenotypes include pharmacogenomic traits such as greater triglyceride lowering ability with fenofibrate treatment, and requirement of high warfarin dosage to elicit anticoagulation response. 6,328 non-coding SNPs associate with 811 phenotype traits: in congruence with medical history of the participant for Type 2 diabetes and β-Thalassemia, and of participant's family for migraine, 72 (of 159 known) Type 2 diabetes, 3 (of 4) β-Thalassemia, and 76 (of 169) migraine variants are seen in the genome. Intergenome comparisons based on shared disease-causing variants, positions the sequenced genome between Asian and European genomes in congruence with geographical location of the region. On comparison, bead arrays perform better than sequencing platforms in correctly calling genotypes in low-coverage sequenced genome regions however in the event of novel SNP or indel near genotype calling position can lead to false calls using bead arrays.We report, for the first time, reference genome resource for the population of Persian ancestry. The resource provides a starting point for designing large-scale genetic studies in Peninsula including Kuwait, and Persian population. Such efforts on populations under-represented in global genome variation surveys help augment current knowledge on human genome diversity.
An Empirical Analysis of the Austrian Business Cycle Theory

The Austrian economists Ludwig von Mises and Friedrich A. Hayek developed a unique theory of the business cycle. In their view, an unsustainable boom ensues when the rate of interest prevailing in the market falls below the natural rate. The boom is characterized not only by an increase in aggregate production but also by a distortion of the structure of production. Similarly, the recession that follows is characterized by a decline in aggregate production as the structure of production is repaired. Hence, the Austrian account of macroeconomic fluctuation stresses the misallocation and reallocation of resources in addition to the overproduction and underproduction of more conventional business cycle theories. In a recent article, Lester and Wolff (Review of Austrian Economics 26(4):433–461, 2013) attempt to consider the empirical relevance of the Austrian view. We argue that the authors’ use of the federal funds rate as an indicator of monetary policy is inappropriate in that it fails to distinguish a low market interest rate from a market interest rate that is low relative to the natural rate. Using an estimate of the natural rate provided by Selgin et al. (2011), we attempt to improve upon their analysis.