Farmers&amp;rsquo; Cohort for Agricultural Work-Related Musculoskeletal Disorders (FARM) Study: Study Design, Methods, and Baseline Characteristics of Enrolled Subjects

The ongoing Farmers' Cohort for Agricultural Work-related Musculoskeletal Disorders (FARM) study was developed to evaluate health status and related factors in farmers.Farmers in Kangwon Province, South Korea, were recruited. Baseline characteristics were determined using questionnaires about sociodemographic and health characteristics and agricultural work-related factors. In addition, laboratory examinations (lumbar spinal radiography and serologic testing) were conducted.The FARM study covers eight rural areas and recruited 1013 subjects (534 women; mean [standard deviation {SD}] age, 57.2 [7.5] years). Musculoskeletal pain in multiple areas was reported by 925 subjects (91.3%), and low back pain (63.8%) was the most frequent site of pain. Farmer's Stress Inventory (mean [SD], 77.7 [10.2]; range, 28-112] and subjective stress index (mean [SD], 5.3 [2.4]; range, 0-10) were above median scale values, reflecting a stressful condition, while the EuroQol-5D-3L index and the EuroQol-Visual Analog Scale scores were high (mean [SD], 0.9 [0.1]; range -0.171-1 and mean [SD], 67.7 [18.7]; range 0-100, respectively), reflecting good life quality. In total, 53% of participants had worked in farming for more than 30 years, and workers involved in dry-field farming comprised the largest subgroup (41.5%). Most participants (94.3%) had no more than a high school education, and families with annual income below 20 million won constituted the largest subgroup (36.3%).The FARM study may provide data on the current health status and related sociodemographic and agricultural work-related risk factors in Korean farmers, with the goal of providing a scientific basis for developing coping interventions and preventive strategies.

section_content: 6] [7] The impact of MSDs in farmers is substantial and results in long-term disability and income loss. Chapman and Meyers reported that MSDs occur over 20 times more frequently than pesticide injuries and illness in United States agriculture, and MSDs have cost the American farming industry in excess of $167 million for reported injuries. 8, 9 dditionally, Kirkhorn et al. reported that agricultural workers are at particular risk of arthritis-related disability. 10 owever, while MSDs in farmers are the cause of significant health problems and result in loss of productivity, previous studies have only demonstrated the higher frequency of MSDs and the impact of workload on MSDs in farmers and have only followed participants for limited durations. Validated longitudinal information about overall agricultural work-related health status and risk factors related to MSDs is urgently needed to improve the health status of farmers. We hypothesized that there might be serial changes in MSDs that are affected by agricultural and work-related factors. 

The purpose of our study was to elucidate the sociodemographic conditions, health characteristics (agricultural work-related stress, frailty, musculoskeletal pain, quality of life, and back pain-related disability), and associated workrelated factors, such as agricultural conditions and workrelated ergonomic risk, in Korean farmers through long-term follow up.
section_name: INTRODUCTION

section_name: METHODS

section_content: The Farmers' Cohort for Agricultural Work-Related Musculoskeletal Disorders (FARM) study was conducted by the Center for Farmers' Safety and Health at Kangwon National University Hospital. We first selected 1822 farmers (aged 40-70 years) who owned or rented a farm in Kangwon Province in South Korea (including Chuncheon, Hongcheon, Hwacheon, Yang-gu, Injae, Cheorwon, Jeongseon, and Seogok) through the agricultural cooperative units. Kangwon Providence had a population of 1. 46 million people in 2010, of which 13. 1% are farmers (compared to the national average of 6. 4%). 11 f the 1822 farmers initially selected, 795 did not participated in our study (586 refusals, 190 unobtainable phone numbers, 9 traveling to other areas, 8 aged ≥70 years, 1 hospitalization, and 1 immobilization). We recruited the remaining 1027 participants from September 2013 through June 2014. Our research team visited each agricultural cooperative unit and conducted the baseline study. The participants were then verified as official farmers by the local representatives in the National Agricultural Cooperative Federation. Finally, amputees (n = 4), nonagricultural workers (n = 9), and very-low-weight (n = 1) subjects were excluded, leaving 1013 included participants in this prospective cohort study (Figure).
section_name: Subjects

section_content: This study was approved by the Institutional Review Board of the Kangwon National University Hospital (IRB No. 2013-06-009-007) and Clinical Research Information Service of Korean National Institutes of Health (ID: KCT0000829) which became a member of the World Health Organization's International Clinical Trials Registry Platform. Additionally, written informed consent was obtained from all participants in the study.
section_name: Standard protocol approvals, registrations, and patient consent

section_name: Questionnaires

section_content: Questionnaires of sociodemographic conditions asked about age, sex, composition of family living together with respondent (number of members and their family relations), marital status, level of education, annual income, occupational history, systemic medical history, family medical history, history of smoking and drinking, and dietary habits (frequency of consumption of each of the foods listed). For women, reproductive history was also obtained.
section_name: Sociodemographic conditions

section_content: Table 1 shows the baseline health characteristics of participants. Agricultural stress was measured using the short form of the Farm Stressor Inventory, which consists of eight domains and 28 questions scored on a 4-point scale. 12 In addition, stress response was also evaluated using a subjective scoring method. 

To evaluate disability associated with back pain, the selfadministered Oswestry Disability Index was used. 13 The Korean Frailty Index, which was created by a panel of experts from the Korean Geriatrics Society, was used to estimate frailty 14 ; the scale includes eight items scored with 0 or 1, and scores of 5-8 were defined as frail, scores of 3-4 as pre-frail, and scores of 0-2 as normal. 

To evaluate the musculoskeletal condition, we used a structured self-reported questionnaire, which was developed by the Korean Occupational Safety and Health Agency. 15 he questionnaire assessed the general musculoskeletal condition and musculoskeletal pain characteristics, as well as consequences of pain during last year. 

We used the EuroQol-5D-3L (EQ-5D-3L) to measure health-related quality of life and stratified respondents into three levels of functioning (no problems, some problems, or extreme problems). The EQ-5D-3L index was calculated using a previously suggested formula. 16 Additionally, respondents rated their current health status according to the EuroQol-Visual Analog Scale (EQ-VAS) from 0 (worst imaginable health) to 100 (best imaginable health) (a detailed list of the evaluated health status items are listed in Table 1 ). Administration. 17 Self-reported agricultural work-related ergonomic risk was investigated using an ergonomic checklist developed by the Korean Rural Development Administration and will be verified by our study through official agreements for use of this checklist in this study. The checklist, composed of 20 items of agricultural work-related body positions, assesses the frequency (none, occasionally, frequently, or always) of adopting those positions per day.
section_name: Health characteristics

section_name: Agricultural work-related factors

section_content: Serologic tests Blood samples (5 cc) were collected, kept in a portable refrigerator after centrifugation, and analyzed at Kangwon National University Hospital for biomarkers related to or predictive of agricultural work-related stress, frailty, and spinal degenerative changes, including C-reactive protein, vitamin D, and dehydroepiandrosterone sulfate. 18, 19 adiographic tests To determine quantitative biomechanical properties of the spine, anteroposterior, neutral lateral, lateral (flexion), and lateral (extension) lumbar radiographs were taken using a portable X-ray vehicle. Disc height change was evaluated using the relative percentage of the disc height of L4-5 and L5-S1 compared with adjacent discs and were graded as 0 (normal), 1 (mild, >75%), 2 (moderate, >50%), 3 (severe, >25%), or 4 (very severe, <25%). Additionally, an L5 osteophyte score was obtained by summing the points of osteophyte formation on eight edges of the vertebral body (no osteophytes = 0, <3 mm = 1 point, ≥3 mm = 2 points) and then graded as 0 (0 points), 1 (1-4 points), 2 (5-8 points), 3 (9-12 points), or 4 (13-16 points). 20 Spondylolisthesis of L5 on S1, lumbar scoliosis, or spondylolysis, and a history of compression fracture or lumbar surgery, were also confirmed using radiographic findings.
section_name: Laboratory examinations

section_content: A follow-up study will be conducted after 1 year, which will include in-depth medical evaluations focused on agricultural work-related musculoskeletal disease, such as spinal bone mineral density, lumbar body composition CT (to show the lumbar back muscle), back muscle strength test, and several performance tests (eg, grip strength, and walking speed). Of the subjects recruited for the primary survey, farmers with <30% of total activity as agriculture-related activity, <30% of total income as agricultural income, and <991. 7 m 2 cultivated land area will be excluded from the secondary survey because of their low representativeness for active farmers' characteristics. below 20 million won (36. 3%), followed by 20-30 million won (20. 6%), 30-40 million won (14. 1%), >50 million won (11. 6%), and 40-50 million won (8. 7%). Regarding smoking status, 35. 7% of participants have smoked more than five packs of cigarettes during the preceding year, and 22. 0% of participants were current smokers. The majority of participants had experience with alcohol drinking (63. 5%), and 54. 3% of participants reported current alcohol consumption (Table 3 ). Table 4 shows the results of health status assessment. Musculoskeletal pain in multiple areas was reported by 925 subjects (91. 3%), and the 1-year prevalence rates were as follows: low back pain (63. 8%), leg/foot pain (43. 3%), shoulder pain (42. 9%), wrist/hands/finger pain (26. 6%), arm/ elbow pain (25. 3%), and neck pain (21. 8%). Farmers' stress was above the median value of the Farmer's Stress Inventory (mean [SD], 77. 7 [10. 2]; range, 28-112) and Subjective Stress Index (mean [SD], 5. 3 [2. 4]; range, 0-10), reflecting a stressful status, while the EuroQol-5D-3L index and the EuroQol-Visual Analog Scale scores were high (mean [SD], 0. 9 [0. 1]; range, -0. 171-1 and mean [SD], 67. 7 [18. 7]; range, 0-100, respectively), reflecting good life quality and subjective health status. Regarding frailty, 174 (17. 2%) subjects were classified as frail or pre-frail.
section_name: Follow-up surveys

section_name: RESULTS

section_content: Medical diagnoses are shown in Table 5. Cardiovascular disease was the most frequently reported disease (28. 8%), followed by musculoskeletal disease (26. 5%) and gastrointestinal disease (25. 6%). Of those reporting a history of cardiovascular disease, patients with hypertension com-prised the highest proportion (26. 0%). For musculoskeletal disease, arthritis comprised the highest proportion (16. 5%).
section_name: Baseline characteristics are described in

section_content: The FARM study is a population-based cohort study that was developed to assess the musculoskeletal health status and related sociodemographic and agricultural work-related risk factors in Korean farmers. A previous systemic review 4 showed that lifetime prevalence of any form of MSD among farmers was 90. 6%, while 1-year MSD prevalence was 76. 9%. Additionally, lifetime low back pain prevalence was 75%, while 1-year low back pain prevalence was 47. 8%. We found self-reported prevalence of MSDs in multiple body parts (91. 3%), and the most frequent pain site was the low back. 

Regarding the characteristics of the study participants compared to overall estimates for farmers in Kangwon Province in 2010, 11 the sex ratio was similar (47. 3% men and 52. 7% women in our study vs 49. 7% men and 50. 3% women in Kangwon province), while the proportions aged ≥65 years (21. 2% vs 33. 4%) and married (91. 1% vs 72. 5%) were different because our study recruited farmers aged 40-70 years in order to improve representativeness of active agricultural workers. Agricultural work involves labor-intensive practices and is related to a multitude of MSD risk factors. 1 There have been some interventions to reduce the demand for labor-intensive practices 21 and to improve working efficacy in an effort to reduce the risk of MSDs. 21, 22 Nevertheless, most Korean farmers suffer due to the harsh working conditions and agricultural work-related MSDs, and there have been few scientific studies to show the actual health status of farmers and the association of MSDs with agricultural workload. Kangwon Province of South Korea is a mountainous area with a high proportion of agricultural workers and a majority of farms that are small in size and that lack access to agricultural machinery. The FARM study may provide information regarding typical farming conditions with high physical demand in Korea. 

The purpose of this study is not only to investigate farmers' baseline characteristics related to MSDs but also to encourage efforts among health professionals, epidemiologists, engineers, and government organizations to reduce incidence of MSDs among farmers. Based on the data acquired, we may report the farmers' health statuses and trends, and the associations of farmers' health statuses with sociodemographic and agricultural work-related risk factors. This data will further identify exposures and contribute to the development of valid interventions for agricultural populations using a multidisciplinary approach. The FARM study may also provide a scientific basis for developing interventions and preventive strategies in Korean farmers.
section_name: DISCUSSION

section_name: ACKNOWLEDGEMENTS

section_content: This study was supported by a Research Grant for Kangwon Center for Farmers' Safety and Health from the Korean Ministry of Agriculture, Food and Rural Affairs.
section_name: ACKNOWLEDGEMENTS

section_content: Conflicts of interest: None declared.