SII-SWORD/CoKE huggingface dataset:
Kinesin-like (Kinesin-like)
Type: Domain

This domain is found in eukaryotes, and is typically between 131 and 151 amino acids in length. There is a single completely conserved residue W that may be functionally important. It is found in some kinesin-like proteins and in Rab GTPase-activating protein 1.
Polo kinase kinase (PKK)
Type: Family

This domain family is found in eukaryotes, and is approximately 140 amino acids in length. The family is found in association with

. Polo-like kinase 1 (Plx1) is essential during mitosis for the activation of Cdc25C, for spindle assembly, and for cyclin B degradation. This family is Polo kinase kinase (PKK) which phosphorylates Polo kinase and Polo-like kinase to activate them. PKK is a serine/threonine kinase.
UBAP2/protein lingerer (UBAP2/Lig)
Type: Family

This entry includes ubiquitin-associated protein 2 (UBAP2) from humans and protein lingerer (lig) from Drosophila melanogaster. Lig is a cytoplasmic protein involved in initiation and termination of copulation . Lig can act as a growth suppressor that associates with the RNA-binding proteins Fragile X messenger ribonucleoprotein 1 (FMR1) and Caprin (Capr) and directly interacts with and regulates the RNA-binding protein Rasputin (Rin) .
Protein of unknown function DUF3698 (DUF3698)
Type: Family

This domain family is found in eukaryotes, and is typically between 89 and 105 amino acids in length.
Golgi associated RAB2 interactor protein-like, Rab2B-binding domain (GARIL-like_Rab2B-bd)
Type: Domain

This domain is found in Golgi-associated RAB2 interactor proteins and it is likely a Rab2B-binding domain . Some members included in this entry, such as GAR1A/B andGAR2, are RAB2B effector proteins required for accurate acrosome formation and normal male fertility . GARIL5 is a Rab2B effector protein which promotes cytosolic DNA-induced innate immune responses and GARI-L4 is a RAB2B effector protein required for the compacted Golgi morphology . This domain is also found in TASOR2, whose function is unknown.
Protein of unknown function DUF3701 (DUF3701)
Type: Family

This domain family is found in bacteria, and is approximately 100 amino acids in length. The family is found in association with

.
E3 Ubiquitin ligase MUL1-like (MUL1-like)
Type: Domain

This domain is found in mitochondrial ubiquitin ligase activator of NFKB 1 (MULAN, also known as MUL1) from animals and ubiquitin E3 Ligase SP1/SP2/SPL1/SPL2 from Arabidopsis.

MUL1 is a multifunctional E3 ubiquitin ligase anchored in the outer mitochondrial membrane with its RING finger domain facing the cytoplasm. Mul1 functions as a ubiquitin ligase to ubiquitinate molecules such as mitofusin2 (Mfn2), Akt, p53 and ULK1, through its RING finger domain, leading to proteins degradation. Moreover, Mul1 can also act as a small ubiquitin-like modifiers (SUMO) E3 ligase to sumoylate proteins such as dynamin-related protein 1 (Drp1), enhancing protein stabilization . It plays a role in the control of mitochondrial morphology, promotes mitochondrial fragmentation and influences mitochondrial localisation . When over-expressed in human cells, it activates JNK through MAP3K7/TAK1 and induces caspase-dependent apoptosis . MUL1 has also been shown to regulate RIG-I mediated antiviral response .
PPE family, C-terminal (PPE_C)
Type: Domain

This domain is found at the C-terminal of bacterial proteins from the PPE family, and is approximately 90 amino acids in length. The domain is found in association with

. There is a conserved SVP sequence motif. There is a single completely conserved residue W that may be functionally important. The proteins in this family are PE/PPE proteins implicated in immunostimulation and virulence.

The human pathogen Mycobacterium tuberculosis harbours a large number of genes that encode proteins whose N-terminals contain the characteristic motifs Pro-Glu (PE) or Pro-Pro-Glu (PPE). These proteins are exported to the bacterial surface via type VII secretion systems known as ESX . A subgroup of the PE proteins contains polymorphic GC-rich sequences (PGRS), while a subgroup of the PPE proteins contains major polymorphic tandem repeats (MPTR). The function of most of these proteins remains unknown . However, the PE_PGRS proteins from Mycobacterium marinum are secreted by components of the ESX-5 system that belongs to the recently defined type VII secretion systems . It has also been reported that the PE_PGRS family of proteins contains multiple calcium-binding and glycine-rich sequence motifs GGXGXD/NXUX. This sequence repeat constitutes a calcium-binding parallel β-roll or parallel β-helix structure and is found in RTX toxins secreted by many Gram-negative bacteria .

PPE51 member has been described as a small molecule-selective channel required for the uptake of nutrients across the outer mycomembrane . This protein transports glycerol and glucose as well as maltose and lactose disaccharides. It is involved in sensitivity to M.tuberculosis growth inhibitory agrichemical 3,3-bis-di(methylsulfonyl)propionamide (3bMP1) and sensitivity to bactericidal thio-disaccharide T-6 compound .
Protein of unknown function DUF3703 (DUF3703)
Type: Family

This family of proteins is found in bacteria. Proteins in this family are typically between 113 and 135 amino acids in length.
Protein of unknown function DUF3704 (DUF3704)
Type: Family

This domain family is found in eukaryotes, and is approximately 30 amino acids in length.
Nuclear receptor coactivator 4, N-terminal (NCOA4_N)
Type: Domain

This entry represents a region found towards the N-terminal of NCOA4 which according to structure predictions it may consist of a long helix combined with disordered segments.

Nuclear receptor coactivator 4, also known as ARA70, is a coactivator for the androgen receptor (AR) and can function as a ligand-enhanced coactivator of PPARgamma. AR can suppress PPARgamma-ARA70 transactivation, suggesting cross-talk between PPARgamma- and AR-mediated responses in adipocytes . NCOA4 has been identified as a selective cargo receptor for the autophagic turnover of ferritinin, a critical process for regulation of iron homeostasis . This entry also includes Nuclear receptor coactivator 4-B from Xenopus laevis which inhibits activation of DNA replication origins, possibly by obstructing DNA unwinding via interaction with the MCM2-7 complex. This protein binds chromatin before initiation of DNA replication and detaches during replication .
BCAS3 domain (BCAS3_dom)
Type: Domain

This domain is found towards the C-terminal of BCAS3 and ATG18-like proteins from plants. In BCAS3, this domain seems to be important for PHAF1 interactions .

This entry includes BCAS3 microtubule associated cell migration factor (BCAS3) from animals and AT18F/G/H from Arabidopsis. BCAS3 is a microtubule associated cell migration factor that has been linked to the development of breast cancer and angiogenesis . It forms a complex with PHAF1 and associates with the preautophagosomal structure during both non-selective and selective autophagy .

AT18F/G/H are linked to autophagy .
Apolipoprotein B100 C-terminal (ApoB100_C)
Type: Domain

This domain is found in the C terminus of some apolipoprotein B100 (ApoB100) proteins. It is approximately 60 amino acids in length and contains two conserved sequence motifs: QLS and LIDL. ApoB100 has an essential role in the assembly and secretion of triglyceride-rich lipoproteins and lipids transport .
Protein of unknown function DUF3709 (DUF3709)
Type: Family

This domain family is found in bacteria, and is approximately 30 amino acids in length. There are two conserved sequence motifs: RCLMK and LIEL.
Cilia- and flagella-associated protein 276 (CFAP276)
Type: Family

This family of proteins is found in eukaryotes. There is a single completely conserved residue D that may be functionally important. The family includes CFAP276 and homologues. Bovin CFAP276 has been identified as a microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating . Members of this family have been suggested to be involved in intracellular Ca2 homeostasis .
Vegetative insecticide protein 3 (Vip3)
Type: Family

This entry includes Vip3A and related proteins, such as Vip3B and Vip3C. They are insecticidal proteins produced during the vegetative growth phase of B. thuringiensis. Vip3A contains a conserved N-terminal domain and a highly variable C-terminal region. After ingestion of the toxin by the larva, Vip3A is activated through proteolytic process by trypsin-like proteases .
Bcl2-/adenovirus E1B 19kDa-interacting protein 2 (Bcl2-/adenovirus-E1B)
Type: Family

This domain family is found in eukaryotes, and is typically between 119 and 133 amino acids in length. There is a conserved HGGY sequence motif. This family is Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2. It interacts with pro- and anti- apoptotic molecules in the cell.
ABC transporter phosphate permease PstC, N-terminal domain (PstC_N)
Type: Domain

This domain is found the high-affinity inorganic phosphate transporter PstC from some bacterial species . It is found in association with

. There is a single completely conserved residue P that may be functionally important.
Protein of unknown function DUF3710 (DUF3710)
Type: Family

This family of proteins is found in bacteria. Proteins in this family are typically between 237 and 284 amino acids in length. There are two conserved sequence motifs: DLG and DGPRW.
Cucumber mosaic virus 1a protein C-terminal (CMV_1a_C)
Type: Domain

This domain family is found in viruses, and is approximately 90 amino acids in length. It is found in association with

,

. and contains a conserved GLG sequence motif. 1a protein is the major virulence factor of the (Cucumber mosaic virus. The Ns strain of CMV causes necrotic lesions to Nicotiana spp. while other strains cause systemic mosaic. The determinant of the pathogenesis of these different strains is the specific amino acid residue at the 461 residue of the 1a protein .
Protein of unknown function DUF3712 (DUF3712)
Type: Family

This domain family is found in Fungi, and is approximately 130 amino acids in length. This domain has a distant similarity to LEA-2 domain .
Protein of unknown function DUF3713 (DUF3713)
Type: Family

This family of proteins is found in bacteria, specifically in Mycoplasmatota. Proteins in this family are typically between 92 and 1225 amino acids in length. There is a single completely conserved residue S that may be functionally important.
Conjugative transposon, TraM (Conjug_transposon_TraM)
Type: Family

Proteins in this entry are designated TraM and are found in a proposed transfer region of a class of conjugative transposon found in the Bacteroides lineage.
TASOR, DUF3715 (TASOR_DUF3715)
Type: Domain

This domain is found in eukaryotes, and is approximately 170 amino acids in length. Proteins containing this domain include TASOR and TASOR 2 (also known as FAM208A/B) proteins .

TASOR is a key component of the HUSH complex, a vertebrate-specific multiprotein complex that mediates epigenetic repression of both exogenous and endogenous genetic elements . The HUSH complex regulates H3K9me3 deposition by promoting recruitment of SETDB1 and also recruits MORC2 to compact chromatin . The HUSH complex represses L1 retrotransposons and is also involved in the silencing of unintegrated retroviral DNA by being recruited by ZNF638: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed . TASOR is crucial in early embryonic development , and contains a catalytically-inactive PARP domain, necessary for epigenetic regulation of target elements.
Smoothelin (SMTN)
Type: Domain

This entry represents a domain found in the smoothelin protein, which is a smooth muscle-specific cytoskeletal protein exclusively found in differentiated smooth muscle cells . This domain is found in association with the calponin homology domain (

).
Protein of unknown function DUF3716 (DUF3716)
Type: Family

This domain family is found in eukaryotes, and is approximately 60 amino acids in length.
Protein of unknown function DUF3717 (DUF3717)
Type: Family

This family of proteins is found in bacteria. Proteins in this family are typically between 75 and 117 amino acids in length. There is a conserved AIN sequence motif. There are two completely conserved residues (L and Y) that may be functionally important.
ATP-dependent RNA helicase SUV3, C-terminal domain (SUV3_C)
Type: Domain

This domain is found in ATP-dependent RNA helicase SUV3. It is found in bacterial and eukaryotic proteins, it is approximately 50 amino acids in length and it is usually found in association with

.

The yeast mitochondrial degradosome (mtEXO) is an NTP-dependent exoribonuclease involved in mitochondrial RNA metabolism. mtEXO is made up of two subunits: an RNase (DSS1) and an RNA helicase (SUV3). These co-purify with mitochondrial ribosomes .
Protein of unknown function DUF3718 (DUF3718)
Type: Family

This domain family is found in bacteria, and is approximately 70 amino acids in length. There is a single completely conserved residue C that may be functionally important.
Domain of unknown function DUF3719 (DUF3719)
Type: Domain

This domain is found in eukaryotes, and is approximately 70 amino acids in length. There is a conserved HLR sequence motif. There are two completely conserved residues (W and H) that may be functionally important. This domain is present in proteins such as primary cilium assembly protein FAM149B1.
Protein of unknown function DUF3720 (DUF3720)
Type: Family

This entry represents a family of uncharacterised proteins found in Trypanosoma.
Protein of unknown function DUF3721 (DUF3721)
Type: Family

This domain family is found in bacteria and eukaryotes, and is approximately 30 amino acids in length. There is a conserved WMPC sequence motif. There are two completely conserved residues (A and C) that may be functionally important.
Protein of unknown function DUF3723 (DUF3723)
Type: Family

This family of proteins is found in eukaryotes. Proteins in this family are typically between 374 and 1069 amino acids in length. There is a conserved LGF sequence motif.
Protein of unknown function DUF3725 (DUF3725)
Type: Family

This domain family is found in viruses, and is approximately 70 amino acids in length. The family is found in association with

. There is a conserved FLE sequence motif.
Herpesvirus glycoprotein L, C-terminal (Herpes_gL_C)
Type: Domain

Herpesviruses are enveloped by a lipid bilayer that contains at least a dozen glycoproteins. The virion surface glycoproteins mediate recognition of susceptible cells and promote fusion of the viral envelope with the cell membrane, leading to virus entry. No single glycoprotein associated with the virion membrane has been identified as the fusogen .

Glycoprotein L (gL) forms a non-covalently linked heterodimer with glycoprotein H (gH). This heterodimer is essential for virus-cell and cell-cell fusion since the association of gH and gL is necessary for correct localisation of gH to the virion or cell surface. gH anchoring the heterodimer to the plasma membrane through its transmembrane domain. gL lacks a transmembrane domain and is secreted from cells when expressed in the absence of gH .

This entry represents Herpesvirus glycoprotein L (gL), which is a virion associated envelope glycoprotein . Heterodimer formation between gH and gL has been demonstrated in both virions and infected cells . Heterodimer formation between gL and gH is important for the proper folding of gH and its insertion into the membrane because the anti-gH conformation-dependent monoclonal antibodies (mAbs) 53S and LP11 bind gH only when gL is present .
Protein of unknown function DUF3726 (DUF3726)
Type: Family

This domain family is found in bacteria and eukaryotes, and is approximately 80 amino acids in length. There is a single completely conserved residue E that may be functionally important.
Hepatitis E virus, hinge domain (Hepatitis-E_hinge)
Type: Domain

This domain of unknown function is found in viruses. Proteins in this family are typically between 145 and 1707 amino acids in length. The family is found in association with

,

,

,

,

. There is a single completely conserved residue L that may be functionally important.
Protein of unknown function DUF3727 (DUF3727)
Type: Family

This domain family is found in bacteria and eukaryotes, and is approximately 100 amino acids in length.
Prepilin peptidase dependent protein C-like, C-terminal domain (PpdC-like_C)
Type: Domain

This entry represents a domain found al proteins mainly found in Enterobacterales, including Prepilin peptidase-dependent protein C from Escherichia coli (PpdC). PpdC is predicted to be a bitopic inner membrane protein. This domain is found in association with

. There are two completely conserved C residues that may be functionally important.
Protein of unknown function DUF3732 (DUF3732)
Type: Family

This domain family is found in bacteria and eukaryotes, and is typically between 180 and 198 amino acids in length. There is a conserved DQP sequence motif.
Firmicutes EssC, N-terminal (Firmicutes_EssC_N)
Type: Domain

This entry represent the N-terminal domain of the proteins EssC from Firmicutes. EssC contains the FtsK domains and is typically between 107 and 121 amino acids in length. It is required for secretion of EsxA and EsxB. It is related to the FtsK/SpoIIIE proteins (

), which are DNA transporters responsible for translocating missegregated chromosomes after the completion of cell division .
Genetic suppressor element-like (GSE-like)
Type: Domain

This domain is found in genetic suppressor element coiled-coil proteins.
Protein of unknown function DUF3737 (DUF3737)
Type: Family

This family of proteins is found in bacteria, archaea and eukaryotes. Proteins in this family are typically between 281 and 297 amino acids in length.
Pre-mRNA splicing factor (CWC25)
Type: Family

This domain family is found in eukaryotes, and is approximately 100 amino acids in length. The family is found in association with

. There is a single completely conserved residue Y that may be functionally important. Cwc25 has been identified to associate with pre-mRNA splicing factor Cef1/Ntc85, a component of the Prp19-associated complex (NTC) involved in spliceosome activation. Cwc25 is neither tightly associated with NTC nor required for spliceosome activation, but is required for the first catalytic reaction.
Transcription activator GCR1-like domain (TF_GCR1-like)
Type: Domain

This domain is approximately 80 amino acids in length and is found in yeast transcriptional activators such as MSN1 , GCR1 and osmostress-induced transcription factor Hot1 .
Poly-beta-hydroxybutyrate polymerase N-terminal (PHBC_N)
Type: Domain

This domain family is found in bacteria and eukaryotes, and is approximately 50 amino acids in length. The family is found in association with

,

. There is a single completely conserved residue W that may be functionally important. PHBC is the third enzyme of the poly-beta-hydroxybutyrate biosynthetic pathway.
Domain of unknown function DUF3741 (DUF3741)
Type: Domain

This domain is found in plant proteins, and is approximately 50 amino acids in length.
Protein of unknown function DUF3742 (DUF3742)
Type: Family

This domain family is found in bacteria, and is approximately 50 amino acids in length. There is a single completely conserved residue Y that may be functionally important.
Mitotic-spindle organizing protein 1 (MZT1)
Type: Family

MOZART1 or Mzt1 is a component of the gamma-tubulin complex and is required for its recruitment to the microtubule organizing centre in humans and yeast . This function is conserved in plant homologues, known as gamma-tubulin complex protein 3 (GCP3)-interacting proteins (GIPs) . Studies in plant homologues GIP1 and GIP2 indicate that they play a major role in nuclear envelope shaping in both cycling and differentiated cells and that they are essential for centromere architecture .
SteA-like C-terminal (SteA-like_C)
Type: Domain

This domain family is found in bacteria, and is approximately 50 amino acids in length. This domain is found at the C-terminal of SteA proteins from Corynebacterium . SteA and SteB are conserved components of the cytokinetic ring among Corynebacterineae that may play a critical role in the final stages of cytokinesis as they probably form a complex to promote cell separation by RipC-FtsEX. They may coordinate peptidoglycan remodeling with the biogenesis of other envelope layers during cell division .
Putative ABC cobalt transporter (ABC_Co_transporter)
Type: Family

This domain family is found in bacteria, and is approximately 70 amino acids in length. The family is found in association with

. There is a conserved REP sequence motif. There is a single completely conserved residue P that may be functionally important. The proteins in this family are frequently annotated as ABC Cobalt transporters however there is little accompanying literature to confirm this.
Protease inhibitor I10, marinostatin (Prot_inh_I10_marinostatin)
Type: Family

This family includes both microviridins and marinostatins. It seems likely that in both cases it is the C terminus which becomes the active inhibitor after post-translational modifications of the full length, pre-peptide. it is the ester linkages within the key, 12-residue. region that circularise the molecule giving it its inhibitory conformation.
ToxR activated gene A lipoprotein domain (TagA_dom)
Type: Domain

This domain is found in bacterial lipoprotein, and is approximately 140 amino acids in length. The domain is found in association with

. There is a conserved GAG sequence motif.
Poxvirus I6, C-terminal (Poxvirus_I6_C)
Type: Domain

This C-terminal domain characterises the poxvirus I6 proteins (also known as OPG082), it is approximately 40 amino acids in length. The domain is found in association with

.
Hemolytic toxin, N-terminal (Hemolysin_N)
Type: Domain

This domain family is found in bacteria, and is approximately 190 amino acids in length. The family is found in association with

,

. This family is a bacterial virulence factor - hemolysin - which forms pores in erythrocytes and causes them to lyse.
Type III restriction/modification enzyme methylation subunit (TypeIII_RM_meth)
Type: Domain

This domain family is found in bacteria, and is approximately 60 amino acids in length. It is found in association with

. There are two completely conserved residues (F and S) that may be functionally important. It is found in bacterial phage resistance proteins, in particular in the methylation subunit of the type III restriction/modification enzyme complex .
Protein of unknown function DUF3747 (DUF3747)
Type: Family

This family of proteins is found in bacteria. Proteins in this family are typically between 215 and 413 amino acids in length. There is a conserved DSNGYS sequence motif.
Protein of unknown function DUF3748 (DUF3748)
Type: Family

This domain family is found in bacteria and eukaryotes, and is approximately 120 amino acids in length.
Protein of unknown function DUF3750 (DUF3750)
Type: Family

This family of proteins is found in bacteria. Proteins in this family are typically between 175 and 265 amino acids in length.
Phage tail fibre protein, N-terminal domain (Phage_tail_fibre_N)
Type: Domain

This entry represents a presumed N-terminal domain found in bacteria and viruses. Some annotation suggests that it may be a tail fibre protein. There are two completely conserved residues (K and W) in these proteins that may be functionally important.
Domain of unknown function DUF3752 (DUF3752)
Type: Domain

This entry represents a domain is found in proteins from eukaryotes. It is typically between 140 and 163 amino acids in length. It is found at the C terminus of GPALPP motifs-containing protein 1 (GPAM1).
Protein of unknown function DUF3754 (DUF3754)
Type: Family

This domain family is found in bacteria, archaea and eukaryotes, and is typically between 135 and 166 amino acids in length. There is a single completely conserved residue P that may be functionally important.