SII-SWORD/CoKE huggingface dataset:
Protein of unknown function DUF6374 (DUF6374)
Type: Family

This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0002024) is described by MIBiG as an example of the following biosynthetic class, polyketide, in particular the nargenicin biosynthetic gene cluster from Nocardia argentinensis .
Protein of unknown function DUF6375 (DUF6375)
Type: Family

This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0001020) is described by MIBiG as an example of the following biosynthetic classes, NRP (non-ribosomal peptide) and polyketide, in particular the muraymycin C1 biosynthetic gene cluster from Streptomyces sp. NRRL 30471 .
Protein of unknown function DUF6376 (DUF6376)
Type: Family

This family of proteins predominantly found in Firmicutes is functionally uncharacterised. This entry includes Uncharacterized lipoprotein YybP from Bacillus subtilis (YYBP). Probably, this family correspond to lipoproteins.
Domain of unknown function DUF6377 (DUF6377)
Type: Domain

This presumed domain is functionally uncharacterised. Proteins in this entry are mainly found in Bacteroidetes. This domain is likely to be present in transcriptional regulators.
Domain of unknown function DUF6378 (DUF6378)
Type: Domain

This domain of unknown function is found in proteins from bacteria and phages and is functionally uncharacterised. This domain is about 100 amino acids in length. It contains two conserved sequence motifs, KxxR and DxxxDxxGY.
C-glycoside deglycosidase beta subunit (CGDB)
Type: Domain

This is the structural domain of C-glycoside deglycosidase beta subunit (CGDB, also known as CarC), a carbon-carbon bond-cleaving enzyme which participates in the metabolism of C-glycosides . It acts on the C6-glycosylated compounds 3''-dehydroisovitexin (3''-oxo-isovitexin) and 3''-dehydroisoorientin (3''-oxo-homoorientin) . In some members, this domain is found in combination with other domains.
Protein of unknown function DUF6380 (DUF6380)
Type: Family

This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0000663) is described by MIBiG as an example of the following biosynthetic class, terpene, in particular the hopene biosynthetic gene cluster from Streptomyces coelicolor A3(2) .
Protein of unknown function DUF6381 (DUF6381)
Type: Family

This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0001558) is described by MIBiG as an example of the following biosynthetic class, polyketide, in particular the cosmomycin C biosynthetic gene cluster from Streptomyces sp. CNT302 . This family appears to be predominantly found in Actinobacteria.
Domain of unknown function DUF6382 (DUF6382)
Type: Domain

This domain of unknown function is present at the N terminaus of uncharacterised proteins predominantly found in Firmicutes, which also contain a FHA (Forkhead-associated) domain. It is approximately 160 amino acids in length and contains a conserved sequence YxI/V motif and a Proline conserved residue.
Domain of unknown function DUF6383 (DUF6383)
Type: Domain

This presumed domain is functionally uncharacterised. This domain is mainly found at the C-terminal of uncharacterised proteins, predominantly from Bacteriodetes. It is about 74 amino acids in length and it contains the GQ and GxxV/IV conserved sequence motifs. This domain has similarity to the Type IX secretion system targeting domain.
Protein of unknown function DUF6384 (DUF6384)
Type: Family

This family of proteins is functionally uncharacterised. Proteins in this family are typically between 306 and 346 amino acids in length and they are predominantly found in Proteobacteria. There is a conserved sequence MDXXdTLRH at the N terminus and a conserved sequence YxxVEA at the C terminus.
Domain of unknown function DUF6385 (DUF6385)
Type: Domain

This presumed domain is functionally uncharacterised. It is mainly found in Firmicutes, and is approximately 80 amino acids in length. There is a conserved sequence motif SG.
HAM1-like, N-terminal domain (HAM1-like_N)
Type: Domain

This entry represents a domain found at the N-terminal end of the putative cell signalling protein HAM1 from Cryptococcus neoformans and similar fungal sequences. HAM1 may act as a negative regulator of mating during vegetative growth . Proteins with this domain often also contain a C-terminal domain (

).
Domain of unknown function DUF5924 (DUF5924)
Type: Domain

This entry represents a domain of unknown function found in bacteria. It is likely to be an integral membrane region with six transmembrane helices. The domain is found in association with PF11141.
Domain of unknown function DUF5925 (DUF5925)
Type: Domain

This domain is functionally uncharacterised and is approximately 180 amino acids in length. In bacteria, this domain is found at the N-terminal of AAA domain-containing proteins. There are three conserved sequence motifs: GWT, ELA and MGFW.
Protein of unknown function DUF5926 (DUF5926)
Type: Domain

This entry represents a presumed domain that is functionally uncharacterised.
Domain of unknown function DUF5927 (DUF5927)
Type: Domain

This entry represents a presumed domain that is functionally uncharacterised. This domain is primarily found in Rhodobacterales, and is approximately 300 amino acids in length. It is found to the C terminus of PF02485 and so is likely to have a role in carbohydrate modification.
Domain of unknown function DUF5928 (DUF5928)
Type: Domain

This presumed domain is functionally uncharacterised. This domain is found predominantly in Rhodobacterales, and is approximately 260 amino acids in length. It is found to the C terminus of PF02485 and therefore is likely to have a role in carbohydrate modification.
Domain of unknown function DUF5929 (DUF5929)
Type: Domain

This presumed domain is functionally uncharacterised. This domain is found in flavobacteria, and is approximately 220 amino acids in length. The family is found to the C terminus of PF04326.
Domain of unknown function DUF5930 (DUF5930)
Type: Domain

This domain is functionally uncharacterised. The domain is found N-terminal to

.
Domain of unknown function DUF5931 (DUF5931)
Type: Domain

This domain is functionally uncharacterised found in actinobacteria, and is approximately 170 amino acids in length. This domain is found at the N terminus of 2 component signalling proteins which also contain PF07730 and PF02518. This domain presumably binds an as yet unknown ligand.
Domain of unknown function DUF5932 (DUF5932)
Type: Domain

Proteins containing this domain are found in bacteria. This domain, which is approximately 110 amino acids in length, is found in association with (

). There is a conserved PIL sequence motif.
Domain of unknown function DUF5933 (DUF5933)
Type: Domain

This domain is functionally uncharacterised, but is found in the PAP2 superfamily and membrane proteins in Bacteria. It is approximately 140 amino acids in length and found in association with PF14378.
Domain of unknown function DUF5935 (DUF5935)
Type: Domain

This presumed domain is functionally uncharacterised, but is is found in O-antigen polymerase proteins. It is mainly found in proteobacteria, and is approximately 190 amino acids in length. The domain is found in association with PF04932.
Domain of unknown function DUF5936 (DUF5936)
Type: Domain

This presumed domain is functionally uncharacterised although it is found in the Type 2 secretion protein F. This domain family is found in Actinobacteria, and is approximately 140 amino acids in length. The family is found in association with PF00482.
Domin of unknown function DUF5937 (DUF5937)
Type: Domain

Proteins containing this domain are functionally uncharacterised but contain a C-terminal DNA-binding HTH domain. This domain is distantly related to PF02624 suggesting it is likely to be a ligand binding domain.
Domain of unknown function DUF5938 (DUF5938)
Type: Domain

This presumed domain is functionally uncharacterised. This domain is found in proteobacteria and actinobacteria, and is approximately 240 amino acids in length. It is found in association with PF03435.
Guanylate cyclase domain-containing protein, N-terminal (GUC-dom-containing_N)
Type: Domain

This presumed domain is found at the N terminus of guanylate cyclase domain-containing proteins and is functionally uncharacterised. It is found mainly in proteobacteria and spirochaetes, and is approximately 280 amino acids in length. It is N-terminal to PF00211.
Domain of unknown function DUF5940 (DUF5940)
Type: Domain

This presumed domain is functionally uncharacterised. This domain family is found mainly in firmicutes, and is approximately 170 amino acids in length. The family is found in association with PF08545.
Domain of unknown function DUF5941 (DUF5941)
Type: Domain

This domain is functionally uncharacterised and mainly found in proteins from actinobacteria. It is found in association with

.
Domain of unknown function DUF5942 (DUF5942)
Type: Domain

This presumed integral membrane domain is functionally uncharacterised. This domain family is found mainly in cyanobacteria and proteobacteria, and is approximately 190 amino acids in length. It is found to the C terminus of PF00082.
Domain of unknown function DUF5943 (DUF5943)
Type: Domain

This presumed domain is functionally uncharacterised. It is found in proteobacteria and sporadically in archaea, and is approximately 100 amino acids in length. There are two conserved sequence motifs: NNH and RLS. This domain is often found to the N terminus of the 4-vinyl reductase (4VR) domain.
Protein of unknown function DUF5944 (DUF5944)
Type: Family

This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0001797) is described by MIBiG as an example of the following biosynthetic class, RiPP (ribosomally synthesised and post-translationally modified peptide).
Protein of unknown function DUF5945 (DUF5945)
Type: Family

This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0000561) is described by MIBiG as an example of the following biosynthetic class, RiPP (ribosomally synthesised and post-translationally modified peptide).
Protein of unknown function DUF5946 (DUF5946)
Type: Family

This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0001707) is described by MIBiG as an example of the following biosynthetic class, RiPP (ribosomally synthesised and post-translationally modified peptide).
Protein of unknown function DUF5947 (DUF5947)
Type: Family

This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0001065) is described by MIBiG as an example of the following biosynthetic class, polyketide.
Protein of unknown function DUF5948 (DUF5948)
Type: Family

This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0001281) is described by MIBiG as an example of the following biosynthetic class, polyketide.
Protein of unknown function DUF5949 (DUF5949)
Type: Family

This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0000700) is described by MIBiG as an example of the following biosynthetic class, saccharide.
DurN substrate-assisted peptide maturase (DurN)
Type: Family

This entry represents a member of a biosynthetic gene cluster (BGC) involved in duramycin biosynthesis, a ribosomally synthesized and post-translationally modified peptide (RiPP) produced by various actinomycetes and marine symbionts. Duramycin binds phosphatidylethanolamine (PE), a major structural phospholipid in mammalian and microbial cell membranes which contains 19 amino acids and 5 post-translational modifications (PTMs).

This entry represents DurN, an enzyme that forms (2S,9S)-Lal one of the two last PTMs. DurN catalyses stereospecific and diastereoselective Lal formation in an unusual substrate-assisted mechanism in which the active site residues that make the reaction proceed come from the substrate itself, maneuvered into position by DurN .
Protein of unknown function DUF5951 (DUF5951)
Type: Family

This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0001805) is described by MIBiG as an example of the following biosynthetic class, NRP (non-ribosomal peptide).
Protein of unknown function DUF5952 (DUF5952)
Type: Family

This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0000178) is described by MIBiG as an example of the following biosynthetic class, polyketide.
Protein of unknown function DUF5953 (DUF5953)
Type: Family

This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0001431) is described by MIBiG as an example of the following biosynthetic classes, NRP (non-ribosomal peptide) and polyketide.
Protein of unknown function DUF5954 (DUF5954)
Type: Family

This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0001973) is described by MIBiG as an example of the following biosynthetic class, other (unspecified).
Protein of unknown function DUF5955 (DUF5955)
Type: Family

This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0001731) is described by MIBiG as an example of the following biosynthetic class, other (unspecified).
Protein of unknown function DUF5956 (DUF5956)
Type: Family

This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0001073) is described by MIBiG as an example of the following biosynthetic classes, NRP (non-ribosomal peptide) and polyketide.
Protein of unknown function DUF5957 (DUF5957)
Type: Family

This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0001062) is described by MIBiG as an example of the following biosynthetic class, polyketide.
Protein of unknown function DUF5958 (DUF5958)
Type: Family

This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0001920) is described by MIBiG as an example of the following biosynthetic class, RiPP (ribosomally synthesised and post-translationally modified peptide).
Protein of unknown function DUF5959 (DUF5959)
Type: Family

This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0001707) is described by MIBiG as an example of the following biosynthetic class, RiPP (ribosomally synthesised and post-translationally modified peptide).
Protein of unknown function DUF5960 (DUF5960)
Type: Family

This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0000561) is described by MIBiG as an example of the following biosynthetic class, RiPP (ribosomally synthesised and post-translationally modified peptide).
Protein of unknown function DUF5961 (DUF5961)
Type: Family

This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0000573) is described by MIBiG as an example of the following biosynthetic class, RiPP (ribosomally synthesised and post-translationally modified peptide).
Protein of unknown function DUF5962 (DUF5962)
Type: Family

This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0000498) is described by MIBiG as an example of the following biosynthetic class, RiPP (ribosomally synthesised and post-translationally modified peptide).
Protein of unknown function DUF5963 (DUF5963)
Type: Family

This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0001171) is described by MIBiG as an example of the following biosynthetic class, RiPP (ribosomally synthesised and post-translationally modified peptide).
Protein of unknown function DUF5964 (DUF5964)
Type: Family

This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0000523) is described by MIBiG as an example of the following biosynthetic class, RiPP (ribosomally synthesised and post-translationally modified peptide).
Protein of unknown function DUF5965 (DUF5965)
Type: Family

This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0000561) is described by MIBiG as an example of the following biosynthetic class, RiPP (ribosomally synthesised and post-translationally modified peptide).
Protein of unknown function DUF5966 (DUF5966)
Type: Family

This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0000498) is described by MIBiG as an example of the following biosynthetic class, RiPP (ribosomally synthesised and post-translationally modified peptide).
Protein of unknown function DUF5967 (DUF5967)
Type: Family

This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0000571) is described by MIBiG as an example of the following biosynthetic class, RiPP (ribosomally synthesised and post-translationally modified peptide).
Protein of unknown function DUF5969 (DUF5969)
Type: Family

This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0000604) is described by MIBiG as an example of the following biosynthetic class, RiPP (ribosomally synthesised and post-translationally modified peptide).
Protein of unknown function DUF5970 (DUF5970)
Type: Family

This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0000616) is described by MIBiG as an example of the following biosynthetic class, RiPP (ribosomally synthesised and post-translationally modified peptide).
Protein of unknown function DUF5972 (DUF5972)
Type: Family

This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0001634) is described by MIBiG as an example of the following biosynthetic class, RiPP (ribosomally synthesised and post-translationally modified peptide).
Lantibiotic duramycin/duramycin B-like (Dur/DurB-like)
Type: Family

This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0001577) is described by MIBiG as an example of the following biosynthetic class, RiPP (ribosomally synthesised and post-translationally modified peptide). It includes lantibiotic duramycin, duramycin B and cinnamycin. Duramycin B is a potent inhibitor of human phospholipase A2. It exhibits only a weak antibacterial activity against B.subtilis, and does not display antimicrobial activity against S.aureus, S.mitis, E.coli, K.pneumoniae, P.vulgaris and C.albicans
Protein of unknown function DUF5974 (DUF5974)
Type: Family

This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0000576) is described by MIBiG as an example of the following biosynthetic class, RiPP (ribosomally synthesised and post-translationally modified peptide).
Protein of unknown function DUF5975 (DUF5975)
Type: Family

This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0000486) is described by MIBiG as an example of the following biosynthetic class, RiPP (ribosomally synthesised and post-translationally modified peptide).
Protein of unknown function DUF5976 (DUF5976)
Type: Family

This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0000624) is described by MIBiG as an example of the following biosynthetic class, RiPP (ribosomally synthesised and post-translationally modified peptide).
Protein of unknown function DUF5977 (DUF5977)
Type: Domain

Domain found as tandem repeats in bacterial surface proteins, commonly associated with PA14 adhesive domain.
Protein of unknown function DUF5978 (DUF5978)
Type: Domain

This presumed domain is found as highly identical tandem repeats in bacterial cell surface proteins associated with Bact_lectin.
Domain of unknown function DUF5979 (DUF5979)
Type: Domain

This domain is found as tandem repeats in bacterial cell surface proteins, associated with TED adhesive domains. This domain contains a conserved lysine, glutamic acid and asparagine diagnostic of an intradomain thioester bond.
Protein of unknown function DUF5980 (DUF5980)
Type: Family

This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0000666) is described by MIBiG as an example of the following biosynthetic class, terpene.
Protein of unknown function DUF5982 (DUF5982)
Type: Domain

This short domain of unknown function is found at the N terminus of PF01103.
Domain of unknown function DUF5983 (DUF5983)
Type: Domain

This domain is mostly found in proteins from proteobacteria that are likely to be phage derived. It is predicted to fold into a β-sheet with α-helices packed on one face. Structure prediction suggests that this domain is likely to form a homodimeric structure. This domain covers the whole legth of the sequence in many proteins and is found at the C-terminal end, associated with

, in others.
Protein of unknown function DUF5984 (DUF5984)
Type: Family

This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0000838) is described by MIBiG as an example of the following biosynthetic class, polyketide, in particular the flexirubin biosynthetic gene cluster from Flavobacterium johnsoniae. This protein has no known function.
Protein of unknown function DUF5985 (DUF5985)
Type: Family

This family of uncharacterised proteins is found mainly in bacteria. Proteins in this family are approximately 90 amino acids in length and contain three transmembrane helices.
Protein of unknown function DUF5986 (DUF5986)
Type: Family

This family of proteins is found mainly in Firmicutes. Proteins in this family are typically between 235 and 254 amino acids in length. There is a single completely conserved residue R that may be functionally important.
Protein of unknown function DUF5987 (DUF5987)
Type: Family

This family of uncharacterised proteins is found in actinobacteria. Many protein in this family are annotated as regulator, but the source of this annotation is uncertain.
Protein of unknown function DUF5988 (DUF5988)
Type: Family

This family of proteins is found in bacteria. There are two conserved sequence motifs: GGP and YEHF.
Protein of unknown function DUF5989 (DUF5989)
Type: Family

This family of proteins is primarily found mainly in bacteria. Proteins in this family are integral membrane proteins that are approximately 50 amino acids in length. There is a C-terminal conserved APFIY sequence motif. This family may have distant partial similarity to PF02694 suggesting this may be a transporter protein.
Protein of unknown function DUF5990 (DUF5990)
Type: Family

This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0001048) is described by MIBiG as an example of the following biosynthetic classes, NRP (non-ribosomal peptide), polyketide, and saccharide. This family includes a protein in the tallysomycin A biosynthetic gene cluster from Streptoalloteichus hindustanus . Some members of this family have been annotated as monooxygenase, but this could not be confirmed.
Protein of unknown function DUF5991 (DUF5991)
Type: Family

This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0001890) is described by MIBiG as an example of the following biosynthetic class, NRP (non-ribosomal peptide). The exemplar is the amphi-enterobactin 1 biosynthetic gene cluster from Vibrio campbellii .
Protein of unknown function DUF5992 (DUF5992)
Type: Family

This family of uncharacterised proteins is found in bacteria.
Protein of unknown function DUF5993 (DUF5993)
Type: Family

This family of integral membrane proteins is found primarily in proteobacteria.
Protein of unknown function DUF5994 (DUF5994)
Type: Family

This entry represents a member of a biosynthetic gene cluster (BGC) mainly found in actinobacteria. This BGC (BGC0000202) is described by MIBiG as an example of the following biosynthetic class, polyketide. This family contains a protein found in the azicemicin B biosynthetic gene cluster from Kibdelosporangium sp. MJ126-NF4 . The function of this protein is unknown.
Protein of unknown function DUF5995 (DUF5995)
Type: Family

This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0000354) is described by MIBiG as an example of the following biosynthetic class, NRP (non-ribosomal peptide). This includes a protein from the friulimicin A biosynthetic gene cluster from Actinoplanes friuliensis .