SII-SWORD/CoKE huggingface dataset:
DMRT5/1, DMB domain (DMRT5_1_DMB_dom)
Type: Domain

This is the DMB domain found at the C-terminal of DMRT5 (also known as Doublesex- and mab-3-related transcription factor A2) and DMRT1 proteins (Doublesex- and mab-3-related transcription factor A1) . DMRT5 is involved in sexual development although not restricted to the developing gonads in vertebrates. This protein, together with DMRT4, has been identified as an important regulator of neurogenesis . This domain is adjacent the DMA domain (

), both of which are required for neuronal differentiation .
Sgo0707-like, N2 domain (Sgo0707-like_N2)
Type: Domain

This entry represents the N2 domain found in the Sgo0707 adhesin protein . This domain is closely related to

.
Domain of unknown function DUF6795 (DUF6795)
Type: Domain

This domain, mainly found in bacteria, is functionally uncharacterised. This domain is approximately 100 amino acids in length and, based on structure prediction and overlaps with other families, belongs to the transthyretin superfamily. It is likely to have a seven stranded β-sandwich fold.
Protein of unknown function DUF6796 (DUF6796)
Type: Family

This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and fungi. Proteins in this family are typically between 220 and 250 amino acids in length.
Domain of unknown function DUF6797 (DUF6797)
Type: Domain

This presumed domain is functionally uncharacterised. This domain is found in bacteria, and is around 100 amino acids in length. This domain is found in association with

. There is a conserved sequence motif GPLP.
Domain of unknown function DUF6798 (DUF6798)
Type: Domain

This presumed domain is functionally uncharacterised. This domain family is mainly found in bacteria and archaea, and is approximately 60 amino acids in length. There is a conserved WxxR sequence motif and a conserved Lys residue. Members of this entry may be transmembrane proteins.
Domain of unknown function DUF6799 (DUF6799)
Type: Domain

This domain is functionally uncharacterised. This domain is found in bacteria and it is approximately 50 amino acids in length.
Protein of unknown function DUF6800 (DUF6800)
Type: Family

This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 60 amino acids in length and have conserved Arginine residues. This family may have an α-helical structure.
Protein of unknown function DUF6573 (DUF6573)
Type: Family

This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and archaea. Proteins in this family are approximately 130 amino acids in length.
Protein of unknown function DUF6574 (DUF6574)
Type: Family

This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria, mainly Firmicutes. Proteins in this family are typically between 116 and 320 amino acids in length. Many members are thought to contain a zinc ribbon domain.
Domain of unknown function DUF6575 (DUF6575)
Type: Domain

This presumed domain is functionally uncharacterised. This domain is found at the N-terminal of bacterial sequences. There some conserved motifs, Y/FL, WL and LP.
Domain of unknown function DUF6576 (DUF6576)
Type: Domain

This presumed domain is functionally uncharacterised. This domain family corresponds to the C-terminal domain of proteins that are thought to belong to the rhomboid family. It is approximately 40 amino acids in length and it is found mainly in Bacteroidetes. It contains the conserved sequences DxILDKI, GYxxL and EKxxL.
Protein of unknown function DUF6577 (DUF6577)
Type: Family

This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria, mainly Bacteroidetes and Firmicutes. Proteins in this family are typically between 239 and 255 amino acids in length. There are some conserved sequences, GxY, EKxxVD and YAxxRR and a conserved His.
Protein of unknown function DUF6578 (DUF6578)
Type: Family

This family of proteins is functionally uncharacterised. This family of proteins is mainly found in Actinobacteria. Proteins in this family are typically between 132 and 185 amino acids in length. There are three conserved motifs, WQ, CCG and GxV.
Protein of unknown function DUF6579 (DUF6579)
Type: Family

This entry represents a family of proteins that is functionally uncharacterised. This family of proteins is found in Fungi. Proteins in this family are approximately 300 amino acids in length. There are some conserved motifs, HxFF, HPD and FHLLI.
Protein of unknown function DUF6580 (DUF6580)
Type: Family

This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and archaea. Proteins in this family are approximately 200 amino acids in length. Some members are hypothetical ECF transporters related to the Gx transporter superfamily.
Transcription factor tau subunit sfc3/Tfc3, C-terminal (Sfc3/Tfc3_C)
Type: Domain

This domain is found in a group of fungal transcription factors, including Tfc3 from budding yeast andSfc3 from fission yeasts .

Tfc3 (also known as Tau138) is one of three subunits of the tauB subcomplex of yeast transcription factor IIIC (TFIIIC) that binds boxB DNA promoter sites of tRNA and similar genes. TFIIIC assembles the initiation complex TFIIIB-TFIIIC-tDNA, sufficient for RNA polymerase III recruitment and function. Tfc3 is essential for cell viability as it is required for RNA polymerase III-mediated transcription.
Protein of unknown function DUF6582 (DUF6582)
Type: Family

This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically around 100 amino acids in length. It includes two conserved motifs, FA and HVRxA.
Domain of unknown function DUF6583 (DUF6583)
Type: Domain

This presumed domain is found in functionally uncharacterised proteins from bacteria, mainly from Firmicutes. There are two highly conserved residues, a Tyr and an Asp.
Protein of unknown function DUF6584 (DUF6584)
Type: Family

This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria, mainly Actinobacteria and Firmicutes. Many members are thought to contain TPR regions. There are two conserved motifs, AxRL and LxxY.
Protein of unknown function DUF6585 (DUF6585)
Type: Family

This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 246 and 268 amino acids in length. There are seven highly conserved Gly residues.
Protein of unknown function DUF6586 (DUF6586)
Type: Family

This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria, mainly in Proteobacteria. Proteins in this family are approximately 150 amino acids in length. There is a conserved motif NQ and a highly conserved Tryptophan residue.
Protein of unknown function DUF6587 (DUF6587)
Type: Family

This family of proteins is functionally uncharacterised. This family of proteins is found in Proteobacteria. Proteins in this family are typically between 80 and 101 amino acids in length and contain four conserved cysteine residues at the C-terminal.
Protein of unknown function DUF6588 (DUF6588)
Type: Family

This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 332 and 351 amino acids in length. There are several conserved Gly residues and two conserved motifs, AQ and GW.
Domain of unknown function DUF6589 (DUF6589)
Type: Domain

This domain of unknown function is mainly found in fungal sequences.
Domain of unknown function DUF6590 (DUF6590)
Type: Domain

This presumed domain found in Fungi is functionally uncharacterised.
Membrane protein Rv1476 (Rv1476-like)
Type: Family

This entry, previously known as DUF6676, represents Membrane protein Rv1476 and related proteins found in actinobacteria. Rv1476 probably affects the expression of genes linked to host macrophage apoptosis and immune response, thereby promoting the survival of Mycobacterium tuberculosis in host macrophages .
Domain of unknown function DUF6677 (DUF6677)
Type: Domain

This domain is found in bacterial integral membrane proteins, which are functionally uncharacterised.
Protein of unknown function DUF6678 (DUF6678)
Type: Family

This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 112 and 148 amino acids in length.
Protein of unknown function DUF6679 (DUF6679)
Type: Family

This family of proteins is functionally uncharacterised. This family of proteins is found in cyanobacteria. Proteins in this family are approximately 100 amino acids in length. There is a conserved DQQRWIE sequence motif.
Domain of unknown function DUF6680 (DUF6680)
Type: Domain

This presumed domain is functionally uncharacterised. This domain family is found in bacteria, and is approximately 120 amino acids in length.
Protein of unknown function DUF6681 (DUF6681)
Type: Family

This family of proteins is functionally uncharacterised. This family of proteins is found in firmicutes. Proteins in this family are typically between 258 and 288 amino acids in length.
Protein of unknown function DUF6683 (DUF6683)
Type: Family

This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 228 and 260 amino acids in length.
Protein of unknown function DUF6684 (DUF6684)
Type: Family

This family of proteins is functionally uncharacterised. This family of proteins is found in archaea. Proteins in this family are typically between 77 and 127 amino acids in length.
Protein of unknown function DUF6685 (DUF6685)
Type: Family

This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 188 and 325 amino acids in length.
Protein of unknown function DUF6686 (DUF6686)
Type: Family

This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 102 and 118 amino acids in length.
Protein of unknown function DUF6687 (DUF6687)
Type: Family

This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and eukaryotes. Proteins in this family are typically between 342 and 363 amino acids in length.
DUF6688, N-terminal domain (DUF6688_N)
Type: Domain

This entry represents the N-terminal integral membrane domain of a group of functionally uncharacterised bacterial proteins. Members are typically between 360 and 412 amino acids in length.
Protein of unknown function DUF6689 (DUF6689)
Type: Family

This family of proteins is functionally uncharacterised. This family of proteins is found in gamma proteobacteria. Proteins in this family are typically between 273 and 287 amino acids in length.
Domain of unknown function DUF6690 (DUF6690)
Type: Domain

This presumed domain is functionally uncharacterised. This domain family is found in Planctomycete bacteria, and is approximately 170 amino acids in length.
Protein of unknown function DUF6691 (DUF6691)
Type: Family

This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria, archaea and eukaryotes. Proteins in this family are typically between 137 and 165 amino acids in length. Proteins in this family are related to the thiosulfate transporter, but appear to be about half the length. This suggests that this family may operate as a dimer to make a functional transporter.
Domain of unknown function DUF6692 (DUF6692)
Type: Domain

Proteins in this entry are functionally uncharacterised. This presumed domain is found in proteins from Alphaproteobacteria. Proteins in this family are typically between 161 and 194 amino acids in length. This family is related to

and is therefore part of the ferritin superfamily.
Protein of unknown function DUF6693 (DUF6693)
Type: Family

This family of small integral membrane proteins is functionally uncharacterised. This family may be distantly related to

. This family of proteins is predominantly found in proteobacteria. Proteins in this family are typically between 104 and 121 amino acids in length.
Protein of unknown function DUF6694 (DUF6694)
Type: Family

This family of proteins is functionally uncharacterised. This family of proteins is found in proteobacteria. Proteins in this family are typically between 109 and 273 amino acids in length.
Domain of unknown function DUF6695 (DUF6695)
Type: Domain

This domain is found in functionally uncharacterised bacterial proteins. This domain is usually associated with

. It is predicted to fold into a partly open β-barrel.
DUF1583_N (DUF1583_N)
Type: Domain

Most of these Rhodopirellula baltica hypothetical proteins also match

.
X-Tfes, XVIPCD (X-Tfes_XVIPCD)
Type: Domain

This conserved domain is found in Xanthomonas VirD4 interacting proteins (XVIPs) and other type IV secretion system (T4SS) specialised in translocating effector proteins (toxic effector proteins, X-Tfes) into competing gram-negative species, leading to target cell death. This domain interacts with the central all-α domain of VirD4. Its structure shows two well ordered N-terminal antiparallel α-helices that pack against a carboxyl-terminal three-stranded antiparallel β-sheet .
Domain of unknown function DUF6697 (DUF6697)
Type: Domain

This entry represents a fungal domain of unknown function.
Protein of unknown function DUF6698 (DUF6698)
Type: Family

This entry represents an uncharacterised family of fungal proteins.
Domain of unknown function DUF6699 (DUF6699)
Type: Domain

This entry represents a domain of unknown function found in uncharacterised sequences mainly from fungi but also in some plants sequences.
U3 small nucleolar RNA-associated protein 20 domain (UTP20_dom)
Type: Domain

This region of tetratricopeptide-like (TPR) repeats is found towards the C-terminal the U3 small nucleolar RNA-associated protein 20 (UTP20) from yeast and its human homologue, also known as Small subunit processome component 20 homolog or DRIM (Down-Regulated In Metastasis) (

). DRIM is differentially expressed in metastatic and non-metastatic human breast carcinoma cells . Proteins of this entry are involved in processing of non-coding RNA
as components of the small-subunit (SSU) processome; SSU processome is involved in the biogenesis of the 18S rRNA . UTP20 is a huge α-solenoid that functions as a scaffold .
Domain of unknown function DUF6701 (DUF6701)
Type: Domain

This entry represents an uncharacterised region found in a wide range of bacterial cell surface proteins.
Protein of unknown function DUF6702 (DUF6702)
Type: Family

This entry represents an uncharacterised family of proteins. Some members of the family are annotated as Peptidase E, but the does not appear to be any evidence to support that assertion.
Domain of unknown function DUF6591 (DUF6591)
Type: Domain

This presumed domain is functionally uncharacterised. This domain family is found in bacteria, mainly Firmicutes and Actinobacteria, and is approximately 80 amino acids in length. It contains a highly conserved tryptophan residue and the conserved sequence YxxxxxxY.
PIR2-like, helical domain (PIR2-like_helical)
Type: Domain

This helical domain is found at the N-terminal of plant E3-ligase proteins, including PP2CA INTERACTING RING FINGER PROTEIN 2 (PIR2, also known as MND1-interacting protein 1) and its paralogues RF4 and RF298 from Arabidopsis. The function of this domain is unknown. PIR2 is the closest homologue of PIR1 (PP2CA interacting RING finger protein 1) and both positively modulate ABA signaling by targeting PP2CA for degradation .
Domain of unknown function DUF6593 (DUF6593)
Type: Domain

This entry represents a domain found in uncharacterised fungal proteins.
Domain of unknown function DUF6594 (DUF6594)
Type: Domain

This entry represents a domain found in uncharacterised fungal proteins that contain a set of C-terminal transmembrane helices. This entry may be related to

.
Copper acquisition factor BIM1-like domain (BIM1-like_dom)
Type: Domain

This domain is found in fungal proteins, including copper acquisition factor BIM1 from Cryptococcus neoformans, a cell surface-bound protein that functions in the copper-accumulation pathway shared by the CUF1-dependent copper transporter CTR1 . BIM1 facilitates copper acquisition in the brain of mammalian hosts and acts as a copper-dependent virulence trait in fungal meningitis . This domain has a lytic polysaccharide monooxygenase-like (LPMO) fold, which are evolutionarily related but have diverged to a different biological function.
Domain of unknown function DUF6596 (DUF6596)
Type: Domain

This presumed domain is found towards the C-terminal of bacterial RNA polymerase ECF sigma factor proteins.
Domain of unknown function DUF6597 (DUF6597)
Type: Domain

This presumed domain is found at the N-terminal of bacterial transcription factor proteins, including the uncharacterised HTH-type transcriptional regulator in mcrB 3'region from Streptomyces lavendulae, suggesting that this may be a regulatory domain that binds to some as yet unknown ligand.
Domain of unknown function DUF6598 (DUF6598)
Type: Domain

This domain is found at the C-terminal of several plant proteins, including 60 kDa jasmonate-induced protein and in some fungal sequences. The function of the domain is unknown.
Protein of unknown function DUF6599 (DUF6599)
Type: Family

This entry represents a family of uncharacterised bacterial proteins.
Protein of unknown function DUF6600 (DUF6600)
Type: Family

This entry represents a bacterial protein of unknown function. It is rich in conserved tryptophan residues and contains a central HYGRW motif that may be of functional importance.
Protein of unknown function DUF6601 (DUF6601)
Type: Family

This entry represents a family found in fungi. The function of this region is unknown. It appears to contain a pair of C-terminal transmembrane helices.
Domain of unknown function DUF6602 (DUF6602)
Type: Domain

This entry represents a bacterial domain of unknown function. This domain is sometimes associated with a

domain. This could suggest this domain has a role in a bacterial cognate of a Ubiquitin-like pathway.
Domain of unknown function DUF6603 (DUF6603)
Type: Domain

This entry represents a large potential domain found in uncharacterised fungal and bacterial proteins.
Domain of unknown function DUF6604 (DUF6604)
Type: Domain

This entry represents a putative domain found at the N-terminal of a wide range of fungal proteins of unknown function.
N,N-dimethylformamidase beta subunit-like, C-terminal (DMFA2_C)
Type: Domain

This entry represents a domain found at the C-terminal of bacterial proteins, including N,N-dimethylformamidase beta (DMFA2) subunit from Paracoccus , the large subunit of dimethylformamidase (DMFase), an enzyme containing a Fe3 ion in the active site that catalyses the hydrolytic cleavage of the amide bond in N,N-dimethyl formamide. This domain is described as domain III, which adopts an α/β/α fold, with five β-strands that are parallel and sandwiched between α-helices. This domain is also found in some uncharacterised fungal sequences.
Domain of unknown function DUF6606 (DUF6606)
Type: Domain

This entry represents a domain of unknown function found at the N-terminal of a variety of proteins that contain

.
Domain of unknown function DUF6801 (DUF6801)
Type: Domain

This domain is found in a variety of bacterial extracellular proteins. It contains a β-barrel structure.
Domain of unknown function DUF6802 (DUF6802)
Type: Domain

This presumed domain is functionally uncharacterised. This domain is found in actinobacteria and itr is typically between 101 and 135 amino acids in length.
Glycoside hydrolase GH146, substrate-binding domain (GH146_SB_dom)
Type: Domain

This domain is found C-terminal in zinc-dependent retaining glycoside hydrolase family GH146 where it is directly involved in substrate binding . This substrate binding domain is usually associated with

,

. Members of GH146 family share with family GH127 a common catalytic domain and an active site structure that is centred around an unusual Zn(Cys)3(Glu) coordination complex.
Protein of unknown function DUF6806 (DUF6806)
Type: Family

This family of proteins is functionally uncharacterised. This family of proteins is found in proteobacteria. Proteins in this family are approximately 210 amino acids in length and their N-terminal share a similar structure with the Crispr-associated endoribonuclease Cas2.
DUF4784_N (DUF4784_N)
Type: Domain

This domain is found to the N-terminal of a WD40-like domain

in a group of uncharacterised proteins from Bacteroidetes.
Protein of unknown function DUF6803 (DUF6803)
Type: Family

This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 162 and 222 amino acids in length. Structurally, proteins in this family are made of four-helix bundle.
Protein of unknown function DUF6804 (DUF6804)
Type: Family

This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 98 and 195 amino acids in length and adopt a helix-rich bundle structure and share a similar fold with a flagellin homologue, hook-associated protein.
Protein of unknown function DUF6703 (DUF6703)
Type: Family

This family of putative integral membrane proteins is functionally uncharacterised. This family of proteins is found in actinobacteria. Proteins in this family are typically between 85 and 118 amino acids in length.
Protein of unknown function DUF6704 (DUF6704)
Type: Family

This family of presumed integral membrane proteins is functionally uncharacterised. This family of proteins is found in actinobacteria. Proteins in this family are typically between 76 and 89 amino acids in length.
Domain of unknown function DUF6705 (DUF6705)
Type: Domain

This presumed domain is functionally uncharacterised. This domain is found in bacteroidetes, and is approximately 170-200 amino acids in length.
Protein of unknown function DUF6706 (DUF6706)
Type: Family

This family of proteins is functionally uncharacterised. This family of proteins is found in bacteroidetes. Proteins in this family are approximately 100 amino acids in length.
Protein of unknown function DUF6707 (DUF6707)
Type: Family

This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 190 and 350 amino acids in length.
Domain of unknown function DUF6708 (DUF6708)
Type: Domain

This presumed domain is functionally uncharacterised. This domain is found in proteobacteria and is approximately 200 amino acids in length.
Protein of unknown function DUF6709 (DUF6709)
Type: Family

This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 340 and 435 amino acids in length.
Protein of unknown function DUF6710 (DUF6710)
Type: Family

This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 220 and 300 amino acids in length.
Protein of unknown function DUF6711 (DUF6711)
Type: Family

This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and viruses. Proteins in this family are typically between 115 and 155 amino acids in length.
Protein of unknown function DUF6712 (DUF6712)
Type: Family

This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and some viral sequences. Proteins in this family are typically between 270 and 340 amino acids in length.
Protein of unknown function DUF6713 (DUF6713)
Type: Family

This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and archaea. Proteins in this family are typically between 117 and 141 amino acids in length.