SII-SWORD/CoKE huggingface dataset:
Protein of unknown function DUF6240 (DUF6240)
Type: Family

This family of bacterial proteins is functionally uncharacterised. Proteins in this family are typically between 969 and 1090 amino acids in length. Some members of this family are thought to be related to the Flagellar hook-length control protein FliK.
Protein of unknown function DUF6241 (DUF6241)
Type: Family

This family of proteins is functionally uncharacterised and it is found mostly in Firmicutes. There are some conserved sequences: HQK and KWG at the N-terminal, and HNxxW near the C-terminal.
Domain of unknown function DUF6242 (DUF6242)
Type: Domain

This presumed domain is functionally uncharacterised. This domain family is found in bacteria, and is approximately 290 amino acids in length. It contains a BNR/Asp box motif at the C-terminal, which contains the characteristic sequence motif SxDxGxT/xW of the BNR family, present as repeats in sialidases and other glycosyl hydrolases .
Protein of unknown function DUF6243 (DUF6243)
Type: Family

This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0001931) is described by MIBiG as an example of the following biosynthetic class, polyketide. It includes a member from the carrimycin biosynthetic gene cluster from unidentified unclassified sequences. This family appears to be predominantly found in Actinobacteria.
Protein of unknown function DUF6244 (DUF6244)
Type: Family

This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0000267) is described by MIBiG as an example of the following biosynthetic classes, polyketide and saccharide. This entry includes a member from the saquayamycin Z biosynthetic gene cluster from Micromonospora sp. Tu 6368 . This family appears to be predominantly found in Actinobacteria.
Protein of unknown function DUF6245 (DUF6245)
Type: Family

This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0000700) is described by MIBiG as an example of the following biosynthetic class, saccharide. It includes a member from the istamycin biosynthetic gene cluster from Streptomyces tenjimariensis .
Protein of unknown function DUF6246 (DUF6246)
Type: Family

This family of proteins found in bacteria and viruses is functionally uncharacterised.
Protein of unknown function DUF6247 (DUF6247)
Type: Family

This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0000345) is described by MIBiG as an example of the following biosynthetic classes, NRP (non-ribosomal peptide) and polyketide. It includes a member from the eponemycin biosynthetic gene cluster from Streptomyces hygroscopicus . This family appears to be predominantly found in Actinobacteria.
Protein of unknown function DUF6248 (DUF6248)
Type: Family

This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0000703) is described by MIBiG as an example of the following biosynthetic class, saccharide. It includes a member from the kanamycin biosynthetic gene cluster from Streptomyces kanamyceticus .
Domain of unknown function DUF6249 (DUF6249)
Type: Domain

This entry represents a domain mainly found in functionally uncharacterised bacterial proteins. It is thought to contain transmembrane regions.
Domain of unknown function DUF6250 (DUF6250)
Type: Domain

This domain is mainly found in bacterial proteins which are functionally uncharacterised. There is a conserved Tryptophan residue at the N-terminal and a highly conserved SDLN sequence.
Protein of unknown function DUF6251 (DUF6251)
Type: Family

This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0000700) is described by MIBiG as an example of the following biosynthetic class, saccharide. It includes a member from the istamycin biosynthetic gene cluster from Streptomyces tenjimariensis .
Protein of unknown function DUF6252 (DUF6252)
Type: Family

This family of proteins found mainly in Bacteroidetes is functionally uncharacterised. A conserved glycine residue and the conserved sequences GTF and GxF can be found at the C terminus.
Protein of unknown function DUF6253 (DUF6253)
Type: Family

This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0001778) is described by MIBiG as an example of the following biosynthetic class, other (unspecified). It includes a member from the showdomycin biosynthetic gene cluster from Streptomyces showdoensis .
Protein of unknown function DUF6254 (DUF6254)
Type: Family

This family of bacterial proteins is functionally uncharacterised. Proteins in this family are typically between 39 and 59 amino acids in length. This family contains a highly conserved sequence HGKV/IKS/T.
Protein of unknown function DUF6255 (DUF6255)
Type: Family

This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0001662) is described by MIBiG as an example of the following biosynthetic class, polyketide. It includes a member from the mediomycin A biosynthetic gene cluster from Kitasatospora mediocidica .
Protein of unknown function DUF6256 (DUF6256)
Type: Family

This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0001215) is described by MIBiG as an example of the following biosynthetic class, NRP (non-ribosomal peptide). It includes a member from the conglobatin biosynthetic gene cluster from Streptomyces conglobatus .
Protein of unknown function DUF6257 (DUF6257)
Type: Family

This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0000700) is described by MIBiG as an example of the following biosynthetic class, saccharide. It includes a member from the istamycin biosynthetic gene cluster from Streptomyces tenjimariensis .
Protein of unknown function DUF6258 (DUF6258)
Type: Family

This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0000974) is described by MIBiG as an example of the following biosynthetic classes, NRP (non-ribosomal peptide) and polyketide. It includes a member from the crocacin biosynthetic gene cluster from Chondromyces crocatus .
Domain of unknown function DUF6259 (DUF6259)
Type: Domain

This domain is mainly found in bacterial proteins and is functionally uncharacterised. However, some proteins containing this domain are putative glycoside hydrolases and this domain has some overlaps with clan family members of CL0058. Proteins containing this domain are typically between 678 and 749 amino acids in length.
Protein of unknown function DUF6260 (DUF6260)
Type: Family

This family of proteins, functionally uncharacterised, is found in bacteria and viruses. Some members are thought to be coat proteins.
Protein of unknown function DUF6261 (DUF6261)
Type: Family

This family of bacterial proteins is functionally uncharacterised. Proteins in this family are typically between 246 and 334 amino acids in length. Some members are thought to be hemagglutinin-related proteins.
Transposase for transposon Tn554-like (TnpC-like)
Type: Family

This entry represents Transposase for transposon Tn554 and related proteins mainly found in firmicutes and actinobacteria. This protein family is one of three encoded by transposon Tn554 and required for its transposition . There is a conserved sequence GV/LSR/K and a highly conserved Tyrosine residue.
Protein of unknown function DUF6263 (DUF6263)
Type: Family

This family of proteins found in bacteria is functionally uncharacterised. Proteins in this family are typically between 298 and 349 amino acids in length. There is a conserved sequence pattern PxxxI/VxxGxxW.
Protein of unknown function DUF6264 (DUF6264)
Type: Family

This family of putative integral membrane proteins is functionally uncharacterised. This family of proteins is found mostly in Actinobacteria.
Domain of unknown function DUF6265 (DUF6265)
Type: Domain

This entry represents a domain functionally uncharacterised. Proteins in this entry are primarily found in bacteria.
Protein of unknown function DUF6266 (DUF6266)
Type: Family

This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. There are two conserved sequence motifs: AMSY and DNS.
Protein of unknown function DUF6267 (DUF6267)
Type: Family

This family of proteins found in myoviruses is functionally uncharacterised.
Domain of unknown function DUF6268 (DUF6268)
Type: Domain

This domain, found in integral membrane β-barrel proteins, is functionally uncharacterised.
Protein of unknown function DUF6269 (DUF6269)
Type: Family

This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0001975) is described by MIBiG as an example of the following biosynthetic class, NRP (non-ribosomal peptide). It includes a member from the atratumycin biosynthetic gene cluster from Streptomyces atratus .
Protein of unknown function DUF6270 (DUF6270)
Type: Family

This family of proteins found in bacteria and archaea is functionally uncharacterised. Proteins in this family are typically between 258 and 528 amino acids in length. There is a conserved GSC sequence motif.
Protein of unknown function DUF6271 (DUF6271)
Type: Family

This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0000093) is described by MIBiG as an example of the following biosynthetic class, polyketide, in particular the meilingmycin biosynthetic gene cluster from Streptomyces nanchangensis . This family appears to be predominantly found in bacteria.
Protein of unknown function DUF6272 (DUF6272)
Type: Family

This family of proteins predominantly found in bacteria is functionally uncharacterised. Proteins in this family have two conserved sequence motifs, ExxQN and GAGLG.
Domain of unknown function DUF6273 (DUF6273)
Type: Domain

This domain is predominantly found in Firmicute bacterial proteins and is functionally uncharacterised. It is found in proteins that are likely to be surface exposed. This domain is frequently found in combination with other carbohydrate-binding domains implying that it may be involved in carbohydrate recognition/binding.
Protein of unknown function DUF6274 (DUF6274)
Type: Family

This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0000119) is described by MIBiG as an example of the following biosynthetic classes, polyketide and saccharide, in particular the 7-deoxypactamycin biosynthetic gene cluster from Streptomyces pactum . This family appears to be predominantly found in Actinobacteria.
Protein of unknown function DUF6275 (DUF6275)
Type: Family

This family of proteins is functionally uncharacterised. This family of proteins is found in Firmicute bacteria and their phage.
Protein of unknown function DUF6276 (DUF6276)
Type: Family

This family of proteins found in archaea is functionally uncharacterised. Proteins in this family contain an N-terminal zinc binding domain.
Protein of unknown function DUF6277 (DUF6277)
Type: Family

This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0001096) is described by MIBiG as an example of the following biosynthetic classes, NRP (non-ribosomal peptide) and polyketide, in particular the FR901464 biosynthetic gene cluster from Pseudomonas sp. 2663 .
Protein of unknown function DUF6278 (DUF6278)
Type: Family

This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0001590) is described by MIBiG as an example of the following biosynthetic class, polyketide, in particular the formicamycins A-M biosynthetic gene cluster from Streptomyces sp. KY5 . This family appears to be predominantly found in Actinobacteria.
Protein of unknown function DUF6280 (DUF6280)
Type: Family

This family of proteins is functionally uncharacterised and found in Alphaproteobacteria.
Protein of unknown function DUF6281 (DUF6281)
Type: Family

This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0000703) is described by MIBiG as an example of the saccharide biosynthetic class. It includes a member from the kanamycin biosynthetic gene cluster from Streptomyces kanamyceticus .
Protein of unknown function DUF6282 (DUF6282)
Type: Family

This family of proteins is functionally uncharacterised and it is predominantly found in bacteria and archaea. This family has some overlaps with families from the clan CL0034.
Protein of unknown function DUF6283 (DUF6283)
Type: Family

This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0001735) is described by MIBiG as an example of the following biosynthetic class, other (unspecified), in particular the pentostatine biosynthetic gene cluster from Streptomyces antibioticus . This family appears to be predominantly found in bacteria.
Protein of unknown function DUF6284 (DUF6284)
Type: Family

This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0000700) is described by MIBiG as an example of the following biosynthetic class, saccharide, in particular the istamycin biosynthetic gene cluster from Streptomyces tenjimariensis . This family appears to be predominantly found in Actinoabactteria.
Domain of unknown function DUF6285 (DUF6285)
Type: Domain

This domain family is predominantly found in bacterial proteins and it is functionally uncharacterised. In some members of this family, thought to be aminoglycoside phosphotransferases, it is located at the C-terminal.
Domain of unknown function DUF6286 (DUF6286)
Type: Domain

This domain family is found in bacterial proteins and is functionally uncharacterised. It has a conserved GV motif.
Domain of unknown function DUF6287 (DUF6287)
Type: Domain

This presumed domain, found in bacteria, is functionally uncharacterised. It is around 50 amino acids in length and contains a conserved GTW sequence motif.
Protein of unknown function DUF6288 (DUF6288)
Type: Family

This family of bacterial proteins is functionally uncharacterised. Proteins in this family are approximately 800 amino acids in length and they presumably contain PDZ domains.
Protein of unknown function DUF6289 (DUF6289)
Type: Family

This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0000385) is described by MIBiG as an example of the following biosynthetic class, NRP (non-ribosomal peptide), in particular the lysobactin biosynthetic gene cluster from Lysobacter sp. ATCC 53042 .
Protein of unknown function DUF6290 (DUF6290)
Type: Family

This family of proteins is functionally uncharacterised, they are predominantly found in bacteria. Proteins in this family presumably contain a ribbon-helix-helix DNA-binding motif.
Domain of unknown function DUF6291 (DUF6291)
Type: Domain

This domain, predominantly found in bacterial and viral proteins, is functionally uncharacterised. It has two conserved residues, a leucine and a tyrosine.
Domain of unknown function DUF6292 (DUF6292)
Type: Domain

This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0001203) is described by MIBiG as an example of the following biosynthetic classes, NRP (non-ribosomal peptide) and polyketide, in particular the clarexpoxcin biosynthetic gene cluster from uncultured bacterium AR_456 . This domain family appears to be predominantly found in Actinobacteria.
HFX_2341-like, N-terminal (HFX_2341-like_N)
Type: Domain

This domain is found at the N-terminal of HFX_2341 from Haloferax mediterranei (

) and similar archaeal proteins. HFX_2341 is a general regulator that affects many metabolic genes and genes of unknown function and is involved in cas gene regulation. It has a significant structural similarity to several CRISPR-associated proteins from archaea specially to Csa3a from Sulfolobus solfataricus . This domain, which has a conserved sequence motif HxxPxxG and a conserved Asparagine residue, is usually associated with an helix-turn-helix domain. It was previously known as DUF6293.
Domain of unknown function DUF6294 (DUF6294)
Type: Domain

This BGC (BGC0000081) is described by MIBiG as an example of the following biosynthetic class, polyketide, in particular the kedarcidin biosynthetic gene cluster from Streptoalloteichus sp. ATCC 53650CC . This domain family appears to be predominantly found in bacteria.
Protein of unknown function DUF6295 (DUF6295)
Type: Family

This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0001922) is described by MIBiG as an example of the following biosynthetic class, polyketide, in particular the isoindolinomycin biosynthetic gene cluster from Streptomyces sp. SoC090715LN-16 . This family appears to be predominantly found in bacteria.
Protein of unknown function DUF6296 (DUF6296)
Type: Family

This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0000187) is described by MIBiG as an example of the following biosynthetic class, polyketide, in particular the asukamycin biosynthetic gene cluster from Streptomyces nodosus subsp. asukaensis . This family appears to be predominantly found in actinobacteria.
Protein of unknown function DUF6297 (DUF6297)
Type: Family

This family of proteins is functionally uncharacterised. Proteins in this family are predominantly found in bacteria and have a conserved sequence motif GPV. Some members of this family are hypothetical ABC transporter permeases.
Domain of unknown function DUF6298 (DUF6298)
Type: Domain

This domain found in bacterial proteins is functionally uncharacterised. Some members of this domain family are thought to be pectin/pectate lyases.
Domain of unknown function DUF6299 (DUF6299)
Type: Domain

This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0000376) is described by MIBiG as an example of the following biosynthetic class, NRP (non-ribosomal peptide), in particular JBIR-34 biosynthetic gene cluster from Streptomyces sp. Sp080513GE-23 . This family appears to be predominantly found in actinobacteria.
Protein of unknown function DUF6300 (DUF6300)
Type: Family

This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0002024) is described by MIBiG as an example of the following biosynthetic class, polyketide, in particular, the nargenicin biosynthetic gene cluster from Nocardia argentinensis . This family appears to be predominantly found in bacteria and unclassified phages.
Protein of unknown function DUF6301 (DUF6301)
Type: Family

This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0001381) is described by MIBiG as an example of the following biosynthetic class, polyketide, in particular the brasilinolide A biosynthetic gene cluster from Nocardia terpenica . This family appears to be predominantly found in Actinobacteria.
Protein of unknown function DUF6302 (DUF6302)
Type: Family

This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0000703) is described by MIBiG as an example of the saccharide biosynthetic class. It includes a member from the kanamycin biosynthetic gene cluster from Streptomyces kanamyceticus .
Protein of unknown function DUF6303 (DUF6303)
Type: Family

This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0000700) is described by MIBiG as an example of the following biosynthetic class, saccharide, in particular the istamycin biosynthetic gene cluster from Streptomyces tenjimariensis . This family appears to be predominantly found in actinobacteria.
Protein of unknown function DUF6304 (DUF6304)
Type: Family

This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0000262) is described by MIBiG as an example of the following biosynthetic classes, polyketide and saccharide, in particular the prejadomycin biosynthetic gene cluster from Streptomyces sp. PGA64 . This family appears to be predominantly found in bacteria.
Domain of unknown function DUF6305 (DUF6305)
Type: Domain

This domain is functionally uncharacterised. Proteins with this domain are predominantly found in bacteria. This domain family may be distantly related to PF09370 suggesting these proteins may function as an enzyme of unknown activity.
Domain of unknown function DUF6306 (DUF6306)
Type: Domain

This domain is functionally uncharacterised. It is predominantly found in bacterial proteins. Protein in this family belong to the ferritin clan.
Protein of unknown function DUF6307 (DUF6307)
Type: Family

This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0000202) is described by MIBiG as an example of the following biosynthetic class, polyketide.
Protein of unknown function DUF6308 (DUF6308)
Type: Family

This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0000699) is described by MIBiG as an example of the following biosynthetic class, saccharide, in particular the hygromycin A biosynthetic gene cluster from Streptomyces hygroscopicus subsp. hygroscopicus . This family appears to be predominantly found in Actinobacteria.
Protein of unknown function DUF6309 (DUF6309)
Type: Family

This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0000078) is described by MIBiG as an example of the following biosynthetic class, polyketide, in particular the incednine biosynthetic gene cluster from Streptomyces sp. ML694-90F3 .
Domain of unknown function DUF6310 (DUF6310)
Type: Domain

This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0001417) is described by MIBiG as an example of the following biosynthetic classes, NRP (non-ribosomal peptide) and polyketide, in particular the myxochromide D biosynthetic gene cluster from Cystobacterineae bacterium . This domain family appears to be predominantly found in Cystobacterineae.
Domain of unknown function DUF6311 (DUF6311)
Type: Domain

This presumed integral membrane domain is functionally uncharacterised. Proteins containing this domain are found in bacteria.
Protein of unknown function DUF6312 (DUF6312)
Type: Family

This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0001772) is described by MIBiG as an example of the following biosynthetic class, polyketide, in particular the scytophycin biosynthetic gene cluster from Anabaena sp. UHCC 0451 .
Protein of unknown function DUF6313 (DUF6313)
Type: Family

This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0000703) is described by MIBiG as an example of the saccharide biosynthetic class. It includes a member from the kanamycin biosynthetic gene cluster from Streptomyces kanamyceticus .
Domain of unknown function DUF6318 (DUF6318)
Type: Domain

This domain, found in Actinobacteria proteins, is functionally uncharacterised.
Protein of unknown function DUF6319 (DUF6319)
Type: Family

This family of proteins found in bacteria is functionally uncharacterised.
Protein of unknown function DUF6320 (DUF6320)
Type: Family

This family of proteins is functionally uncharacterised. This family of proteins is mainly found in Firmicute bacteria.
Domain of unknown function DUF6321 (DUF6321)
Type: Domain

This presumed domain is functionally uncharacterised. This domain family is predominantly found in bacteria and viruses, and is approximately 80 amino acids in length. It has a conserved sequence GGLxxxGRxxY and a conserved tryptophan residue at the C-terminal.
Protein of unknown function DUF6322 (DUF6322)
Type: Family

This family of proteins, predominantly found in Caudovirales, is functionally uncharacterised. Proteins in this family are approximately 150 amino acids in length. There are conserved sequences: ETINSMDYNTGY at the N-terminal, WTG in the centre and TDTTS at the C-terminal.
Protein of unknown function DUF6323 (DUF6323)
Type: Family

This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0001520) is described by MIBiG as an example of the following biosynthetic class, polyketide, in particular the aurantinin B biosynthetic gene cluster from Bacillus subtilis . This family appears to be predominantly present in Firmicutes.
Protein of unknown function DUF6324 (DUF6324)
Type: Family

This family of proteins is functionally uncharacterised and is found in bacteria. Proteins in this family have two conserved sequence motifs: QIGPT and GMVR.
Protein of unknown function DUF6325 (DUF6325)
Type: Family

This family of proteins is functionally uncharacterised and is predominantly found in bacteria.