SII-SWORD/CoKE huggingface dataset:
Mitochondrial protein cyt-4, winged helix domain (WH_CYT4)
Type: Domain

This entry represents a winged helix domain found in mitochondrial protein CYT4 from Neurospora crassa and related fungal sequences.

CYT4 is a nuclear-encoded protein that plays a crucial role in RNA processing and splicing within mitochondria . CYT4 is required for mitochondrial RNA 5'- and 3'-end processing and splicing .
Mitochondrial protein cyt-4, SH3 domain (SH3_CYT4)
Type: Domain

This entry represents a SH3 domain found in mitochondrial protein CYT4 from Neurospora crassa and related fungal sequences.

CYT4 is a nuclear-encoded protein that plays a crucial role in RNA processing and splicing within mitochondria . CYT4 is required for mitochondrial RNA 5'- and 3'-end processing and splicing .
Phage zinc binding domain (Znf_bind_phage)
Type: Domain

This entry represents a small zinc binding domain found in a small family of uncharacterised mycobacterium phage proteins.
Bacteriophage transmembrane helix (TM_bacteriophage)
Type: Family

This entry represents a family of proteins of unknown function found in mycobacteriophage. The family includes short proteins between 44-60 amino acids in length that contain a single predicted transmembrane helix. The presence of these proteins in numerous mycobacteriophage suggests they may play a role in phage biology, but their specific function has yet to be determined experimentally.
Monkey King protein, C-terminal domain (Mkg_C)
Type: Domain

This entry represents the C-terminal domain of a family of proteins largely found in insect species. This domain structurally resembles the KA1 domain

. This domain is found in the Monkey King proteins . Monkey King is a Drosophilidae-specific protein that emerged from duplication and divergence of the ancestral TUTase6 gene .
N4BP1, first type I KH-domain (KH_N4BP1_1st)
Type: Domain

This domain is found in the N4BP1 family which includes NEDD4-binding protein 1, KHNYN, NYNRIN and other related proteins. Members of this family contain two type I K homology (KH) domains. This entry represents the first KH domain.

N4BP1 is a potent suppressor of cytokine production that acts as a regulator of innate immune signalling and inflammation . It acts as a restriction factor against some viruses, such as HIV-1. N4BP1 restricts HIV-1 replication by binding to HIV-1 mRNAs and mediating their degradation via its ribonuclease activity .
N4BP1, second type I KH-domain (KH_N4BP1_2nd)
Type: Domain

This domain is found in the N4BP1 family which includes NEDD4-binding protein 1, KHNYN, NYNRIN and other related proteins. Members of this family contain two type I K homology (KH) domains. This entry represents the second KH domain. Besides the typical for the KH domains secondary structures and topology, this domain contains a C-terminal extension consisting of three α-helices that define a small helical bundle domain.

N4BP1 is a potent suppressor of cytokine production that acts as a regulator of innate immune signalling and inflammation . It acts as a restriction factor against some viruses, such as HIV-1. N4BP1 restricts HIV-1 replication by binding to HIV-1 mRNAs and mediating their degradation via its ribonuclease activity .
N4BP1, UBA-like domain (UBA_N4BP1)
Type: Domain

This domain is found in the human NEDD4-binding protein 1 (N4BP1) and related proteins. It has a significant sequence and structural similarity to UBA domains. This domain is predicted to adopt a globular structure consisting of a three helical bundle.

N4BP1 is a potent suppressor of cytokine production that acts as a regulator of innate immune signalling and inflammation . It acts as a restriction factor against some viruses, such as HIV-1. N4BP1 restricts HIV-1 replication by binding to HIV-1 mRNAs and mediating their degradation via its ribonuclease activity .
Domain of unknown function DUF7730 (DUF7730)
Type: Domain

This domain is found in uncharacterised fungal proteins, including the uncharacterised protein AN11006 from Emericella nidulans (

). It contains a highly conserved EXR sequence motif.
Domain of unknown function DUF7731 (DUF7731)
Type: Domain

This entry represents a domain found in uncharacterised plant proteins. It contains a set of conserved cysteines that are predicted to form disulfide bonds.
Domain of unknown function DUF7732 (DUF7732)
Type: Domain

This domain is found in uncharacterised proteins mainly from fungi. It contains a set of conserved cysteine residues which are predicted to form a disulfide bond.
Domain of unknown function DUF7733 (DUF7733)
Type: Domain

This domain is found in uncharacterised proteins mainly from plants. It is predicted to fold into a structure consisting of six transmembrane helices.
Domain of unknown function DUF7734 (DUF7734)
Type: Domain

This domain is found in uncharacterised proteins. It is predicted to adopt globular structure consisting of a curved β-sheet and α-helices packed on one side of it. It contains a semi-conserved FKGFSS sequence motif.
Domain of unknown function DUF7735 (DUF7735)
Type: Domain

This domain is found in uncharacterised proteins mainly from fungi. It is predicted to form a globular structure consisting of α-helices. It contains a set of conserved cysteine residues which are predicted to form disulfide bridges.
Domain of unknown function DUF7736 (DUF7736)
Type: Domain

This entry represents a small family of bacterial and phage proteins that are uncharacterised. The domain is composed of three α-helices, which dimerise to create a larger structure. Some members of the families contain two copies of this domain, most appear to homodimerise.
Domain of unknown function DUF7737 (DUF7737)
Type: Domain

This domain is found in proteins that contain

. The function of this domain is unknown.
Domain of unknown function DUF7738 (DUF7738)
Type: Domain

This entry represents a family of uncharacterised bacterial protein domains. The structure of these proteins shows some structural similarity to the PePSy domain.
Domain of unknown function DUF7739 (DUF7739)
Type: Domain

This entry includes the Shigella phage Sf6 gene 22 protein

.
Domain of unknown function DUF7740 (DUF7740)
Type: Domain

This entry represents a family of phage proteins. The core structure of these proteins is a conserved four helix bundle. The function of these proteins is unknown.
Domain of unknown function DUF7741 (DUF7741)
Type: Domain

This is a presumed domain found in a group of uncharacterised sequences from worms. This domain may consist of eight beta-strands.
Domain of unknown function DUF7742 (DUF7742)
Type: Domain

This entry represents a likely uncharacterised phage protein. The protein is composed of three α-helices.
Domain of unknown function DUF7743 (DUF7743)
Type: Domain

This is a presumed domain of unknown function found in uncharacterised proteins from Dictyosteliales. It may adopt a Ig-like fold.
Domain of unknown function DUF7744 (DUF7744)
Type: Domain

This entry represents the C-terminal domain of a small set of proteins belonging to the

. Structure prediction suggests that this domain may mediate dimerisation.
Domain of unknown function DUF7745 (DUF7745)
Type: Domain

This domain is found in uncharacterised proteins mainly from plants. It has detectable similarity to plant mobile domains and it is predicted to adopt similar structure.
Domain of unknown function DUF7746 (DUF7746)
Type: Domain

This presumed domain is found in a group of plant sequences, whose function is unknown. This domain may adopt a three-helical bundle fold.
Domain of unknown function DUF7747 (DUF7747)
Type: Domain

This domain is found in uncharacterised protein ZK892.6 from Caenorhabditis elegans and related proteins. It is found either standalone or in combination with other domains. Some proteins contain multiple copies of this domain. It is predicted to adopt a globular structure consisting of an antiparallel six-stranded β-sheet and α-helices packed on both sides of it. This domain contains a highly conserved PxxPP motif.
Domain of unknown function DUF7748 (DUF7748)
Type: Domain

This domain is found in uncharacterised proteins from plants. It is predicted to fold into a β-sandwich.
Ras guanine nucleotide exchange factor glfB-like, C-terminal (GlfB-like_C)
Type: Domain

This domain is found at the C-terminal of Ras guanine nucleotide exchange factor glfB from Dictyostelium discoideum and in similar uncharacterised proteins from lower eukaryotes. GflB is a GpaB-activated, rapA-specific guanine nucleotide exchange factor, involved in the regulation of the balance between Ras and Rap signalling at the leading edge of chemotaxing cells . This protein also acts as a key regulator of actin-driven membrane protrusions during processes such as phagocytosis and cytokinesis, possibly by modulating rapA signalling pathways . This domain is predicted to adopt a globular α/β structure.
Domain of unknown function DUF7750 (DUF7750)
Type: Domain

This is a domain of unknown function found in plant sequences. It may adopt a three-helical bundle fold.
Domain of unknown function DUF7751 (DUF7751)
Type: Domain

This domain is found in a group of uncharacterised plant proteins with the AAA domain (

). This domain is predicted to adopt an all alpha configuration.
Domain of unknown function DUF7752 (DUF7752)
Type: Domain

This domain is found in a group of uncharacterised animal proteins that also contain

. This domain is predicted to adopt a mainly α-helical structure. Its specific function is unknown.
Domain of unknown function DUF7753 (DUF7753)
Type: Domain

This is a presumed domain found at the C-terminal of a group of worm proteins. This domain may adopt a hairpin fold.
Domain of unknown function DUF7754 (DUF7754)
Type: Domain

This is a presumed domain found at the C-terminal of worm proteins. It may be related to BACK domains.
Domain of unknown function DUF7755 (DUF7755)
Type: Domain

This is a domain of unknown function found in plants. This domain is structurally related to Lipase/lipooxygenase domain (PLAT/LH2 domain).
Domain of unknown function DUF7756 (DUF7756)
Type: Domain

This is a presumed domain found in sequences from Strongyloides stercoralis and similar worms. It may adopt a β-sandwich fold related to MATh domains.
Domain of unknown function DUF7757 (DUF7757)
Type: Domain

This is a presumed domain found at the N-terminal of a set of sequences from Strongyloides stercoralis and similar worms. It may adopt a β-sandwich fold, related to MATH domains.
Repeat of unknown function DUF7758 (DUF7758)
Type: Domain

This domain is found in uncharacterised proteins mainly from nematodes. It is composed of repetitive α-helical hairpins and has detectable similarity to 14-3-3 proteins.
Domain of unknown function DUF7759 (DUF7759)
Type: Domain

This domain is found in uncharacterised proteins mainly from flagellate Discoba. It has detectable similarity to known PDZ domains and it is predicted to adopt similar structure. It is frequently found in multiple tandem copies.
Domain of unknown function DUF7760 (DUF7760)
Type: Domain

This domain is found in uncharacterised proteins mainly from flagellate Discoba. It is predicted to adopt a globular structure consisting of array of helices.
Domain of unknown function DUF7761 (DUF7761)
Type: Domain

This domain is found in uncharacterised proteins mainly from flagellate Discoba.
Domain of unknown function DUF7762 (DUF7762)
Type: Domain

This domain is found in uncharacterised proteins mainly from flagellate Discoba. It has detectable similarity to known PDZ domains and it is predicted to adopt similar structure. It is frequently found in multiple tandem copies.
Domain of unknown function DUF7763 (DUF7763)
Type: Domain

This domain is found in uncharacterised proteins mainly from Streptococcus. It is predicted to adopt globular structure consisting of four α-helices.
DISARM protein DrmE, C-terminal (DrmE_C)
Type: Domain

This domain is found at the C-terminal end of DISARM protein DrmE from Bacillus paralicheniformis and similar uncharacterised prokaryotic proteins.

DrmE is a component of antiviral defense system DISARM (defense island system associated with restriction-modification), composed of DrmE, DrmA, DrmB, DrmC and DrmMII. DISARM is probably a multi-gene restriction module, but DrmE has an unknown function. Expression of DISARM in B.subtilis (strain BEST7003) confers resistance to phages Nf, phi29, phi105, phi3T, SPO1, SPR and SPP1. DISARM does not interfere with phage adsorption, but instead interferes with (phi3T) DNA replication early in its cycle, preventing replication, circularization and lysogeny and probably causes phage DNA degradation .
Domain of unknown function DUF7765 (DUF7765)
Type: Domain

This domain is found in uncharacterised proteins mainly from Enterobacterales. It is predicted to fold into a β-barrel.
Outer surface lipoprotein BB0158 (BB0158-like)
Type: Domain

This domain, previously known as DUF7766, is found in Outer surface lipoprotein BB0158 from Borrelia burgdorferi and related proteins mainly from Spirochaetales. It folds into a double β-barrel structure capped with α-helices

. This domain forms a swapped dimer in which the N-terminal β-strand from one monomer is replaced the N-terminal β-strand from the other monomer . BB0158 is part of a family of paralogous proteins found in B. burgdorferi, known as paralogous gene family 44 (PFam44) . This protein potentially plays a role in the pathogenesis of Lyme disease.
Domain of unknown function DUF7767 (DUF7767)
Type: Domain

This is a domain of unknown function found at the C-terminal of fungal sequences. It may adopt a ubiquitin-like fold.
Domain of unknown function DUF7768 (DUF7768)
Type: Domain

This entry represents a domain found in uncharacterised bacterial proteins. It has a detectable similarity to domains members of N-(deoxy)ribosyltransferase-like superfamily and is predicted to adopt similar structure.
Domain of unknown function DUF7769 (DUF7769)
Type: Domain

This is a presumed domain found in plant sequences. It may consist in a tri-helical fold.
Domain of unknown function DUF7770 (DUF7770)
Type: Domain

This entry represents a domain found in uncharacterised proteins. It is predicted to adopt a globular structure that resembles the conserved core of the PPPDE superfamily (after Permuted Papain fold Peptidases of DsRNA viruses and Eukaryotes) which consists of thiol peptidases with a circularly permuted papain-like fold. This domain is found either standalone or in combination with other domains.
Domain of unknown function DUF7771 (DUF7771)
Type: Domain

This domain is found in uncharacterised plant proteins. It is predicted to fold into a β-sandwich with structural similarity to Transthyretin-like domains in particular to SPH (Self-Incompatibility Protein Homologue) proteins.
Protein of unknown function DUF7772 (DUF7772)
Type: Family

This entry represents a group of uncharacterised worm proteins. They contain highly conserved cysteine residues that are predicted to form disulfide bonds. It is likely that these proteins are secreted.
Domain of unknown function DUF7773 (DUF7773)
Type: Domain

This domain is found in uncharacterised worm proteins mainly from clade Rhabditida. It contains a number of highly conserved cysteine residues that are predicted to form disulfide bonds. This domain is predicted to fold into a four-stranded antiparallel meander decorated with α-helices.
Domain of unknown function DUF7774 (DUF7774)
Type: Domain

This domain is found in uncharacterised worm proteins mainly from clade Rhabditida. It is predicted to adopt a globular structure composed of array of α-helices.
Domain of unknown function DUF7775 (DUF7775)
Type: Domain

This domain is found in uncharacterised insect proteins mainly from clade Diptera. It is predicted to fold into a four helical bundle which shares detectable similarity to Marvel-like domains. Some proteins contain two copies of this domain. It is likely to be associated with membrane.
Domain of unknown function DUF7776 (DUF7776)
Type: Domain

This domain is found in HFX_2341 from Haloferax mediterranei and similar archaeal proteins. HFX_2341 is a global regulator involved in cas gene regulation. This domain is often found associated with

.
Domain of unknown function DUF7777 (DUF7777)
Type: Domain

This domain is found exclusively in Trichomonas proteins. It is predicted to fold into an α/β structure.
Domain of unknown function DUF7778 (DUF7778)
Type: Domain

This domain is found in uncharacterised worm proteins. It has a detectable similarity to known PH domains and it is predicted to adopt similar structure.
Domain of unknown function DUF7779 (DUF7779)
Type: Domain

This is a presumed domain found in uncharacterised sequences from fungi. It may be a winged helix domain according to structure predictions.
Domain of unknown function DUF7780 (DUF7780)
Type: Domain

This domain is found in uncharacterised plant proteins. It has a detectable similarity to known glycosyltransferases clan GT-A and is predicted to adopt similar structure.
Domain of unknown function DUF7781 (DUF7781)
Type: Domain

This domain is found in uncharacterised plant proteins. It is predicted to fold into a β-meander that coils to form an open barrel-like structure.
Domain of unknown function DUF7782 (DUF7782)
Type: Domain

This is a presumed domain found at the C-terminal of a group of uncharacterised sequences from Nocardia sp. According to structure predictions, this domain may adopt a winged helix fold with an insertion consisting of a long β-hairpin and a short β-strand.
Domain of unknown function DUF7783 (DUF7783)
Type: Domain

This domain is found in uncharacterised fungal proteins. It is predicted to fold into a four-helical up-and-down bundle. It has a detectable similarity to Talin 1-like four-helical domains.
Domain of unknown function DUF7784 (DUF7784)
Type: Domain

This domain is found in uncharacterised fungal proteins. It is predicted to adopt an up-and-down four-helical bundle.
Domain of unknown function DUF7785 (DUF7785)
Type: Domain

This is a presumed domain found in a group of uncharacterised fungal sequences.
Protein of unknown function DUF7786 (DUF7786)
Type: Family

This family represents a group of uncharacterised proteins from arthropod-infecting viruses.
Domain of unknown function DUF7787 (DUF7787)
Type: Domain

This domain is found in uncharacterised plant proteins. It contains the so-called HeH motif (helix-extended loop-helix). This motif is known to engage in protein-protein and/or nucleic acid interactions. Some proteins contain two copies of this domain.
Domain of unknown function DUF7788 (DUF7788)
Type: Domain

This is a vWA-like domain found at the C-terminal of uncharacterised proteins containing the

domain at the N-terminal .
Domain of unknown function DUF7789 (DUF7789)
Type: Domain

This domain is found in uncharacterised eukaryotic proteins. It is predicted to fold into a four-helical up-and-down bundle. It is usually found in two tandem copies. This domain is likely associated with the membrane.
Domain of unknown function DUF7790 (DUF7790)
Type: Domain

This domain is found in uncharacterised protein from Leptospira interrogans serogroup Icterohaemorrhagiae serovar Copenhageni and related bacterial proteins. Its structure was determined (

) and shares a significant similarity to various methyltransferases.
Domain of unknown function DUF7791 (DUF7791)
Type: Domain

This domain is found in a group of uncharacterised fungal proteins that also contain the domain

at its N-terminal end. This domain is predicted to have a mainly α-helical configuration.
Domain of unknown function DUF7792 (DUF7792)
Type: Domain

This domain is found N-terminal in uncharacterised eukaryotic proteins. It has detectable similarity to domains members of the MLKL N-terminal domain superfamily and is predicted to adopt similar structure.
Domain of unknown function DUF7793 (DUF7793)
Type: Domain

This domain is found in uncharacterised bacterial proteins. A member from Arthrobacter sp. FB24 forms a swapped dimer (

) in which one monomer exchanges a three-stranded β-sheet and an α-helix with the other monomer. The structure of this domain shares detectable similarity to SpoIIAA-like domains.
Domain of unknown function DUF7794 (DUF7794)
Type: Domain

This domain is found in uncharacterised plant proteins. It is predicted to fold into a globular structure with significant structural similarity to alkaline phosphatases.
Domain of unknown function DUF7795 (DUF7795)
Type: Domain

This domain is fund in uncharacterised plant proteins. It is predicted to fold into alpha- helical bundle.
Domain of unknown function DUF7796 (DUF7796)
Type: Domain

This domain is found in uncharacterised proteins mainly from plants. It is predicted to adopt a globular alpha/ beta structure containing several disulfide bonds made by highly conserved cysteine residues.
Domain of unknown function DUF7797 (DUF7797)
Type: Domain

This domain is found in a group of uncharacterised plant proteins. This domain is often found associated with

and is predicted to have an all-α helical configuration.
Domain of unknown function DUF7798 (DUF7798)
Type: Domain

This domain is found in uncharacterised proteins mainly from plants. It is predicted to fold into an α-helical bundle.
Repeat of unknown function DUF7799 (DUF7799)
Type: Domain

This entry represents a presumed domain found towards the N-terminal of a group of uncharacterised sequences from C. elegans and related proteins from nematodes. This domain may consist of spectrin repeats.
Domain of unknown function DUF7800 (DUF7800)
Type: Domain

This domain is found at the N-terminal end of a group of uncharacterised bacterial proteins that also contain

. This domain is predicted to show an immunoglobulin-like fold.
Domain of unknown function DUF7801 (DUF7801)
Type: Domain

This domain is found in a group of uncharacterised fungal proteins. This domain is often found associated with

and is predicted to show a helical configuration.
Domain of unknown function DUF7802 (DUF7802)
Type: Domain

This domain is found in uncharacterised bacterial and eukaryotic proteins. It is predicted to contain nine transmembrane helices arranged in a bundle. This domain has similarity to domains members of the INSIG-like superfamily.
Domain of unknown function DUF7803 (DUF7803)
Type: Domain

This domain is found in uncharacterised proteins mainly from plants. It is predicted to fold into four helices that form two helical hairpins arranged in V-shape.
Domain of unknown function DUF7804 (DUF7804)
Type: Domain

This domain is found in uncharacterised plant proteins. It is predicted to fold into a globular structure consisting of a antiparallel β-sheet curved around a central α-helix.
Domain of unknown function DUF7805 (DUF7805)
Type: Domain

This domain is found in a group of uncharacterised proteins from animals. Many proteins in this group also contain

.
Domain of unknown function DUF7806 (DUF7806)
Type: Domain

This domain is found in uncharacterised plant proteins. It is predicted to adopt a globular structure with similarity to members of the Kinetochore globular domain-like superfamily.
Protein of unknown function DUF7807 (DUF7807)
Type: Family

This entry represents uncharacterised worm proteins. They are predicted to fold into two alpha-hairpins arranged in V-shape.
Domain of unknown function DUF7808 (DUF7808)
Type: Domain

This domain is found in Uncharacterized protein T05H10.3 from C.elegans and related nematode proteins. It is predicted to adopt a β-sandwich with similarity to domains members of H-lectin-like superfamily. This domain contains several highly conserved cysteine residues that are predicted to form disulfide bonds.
Domain of unknown function DUF7809 (DUF7809)
Type: Domain

This domain is found in a group of uncharacterised proteins from animals. It is predicted to adopt a mainly α-helical configuration.
Protein of unknown function DUF7810 (DUF7810)
Type: Family

This entry represents uncharacterised plant proteins that share detectable similarity with members of the Glycosyl transferase clan GT-B.
Domain of unknown function DUF7811 (DUF7811)
Type: Domain

This domain is found in uncharacterised plant proteins. It is predicted to fold into a five-stranded antiparallel β-sheet and two α-helices packed on it.