SII-SWORD/CoKE huggingface dataset:
Domain of unknown function DUF5736 (DUF5736)
Type: Domain

This entry represents a highly conserved domain of unknown function found in various Platyhelminthes.
N-alpha-acetyl diaminobutyric acid deacetylase-like (N-alpha-Ac-DABA-like)
Type: Family

This family represents N-alpha-acetyl diaminobutyrate deacetylase and similar proteins, including succinylglutamate desuccinylase.

N-alpha-acetyl diaminobutyrate deacetylase DoeB (also known as EutE) is involved in the ectoine degradation pathway in Halomonas elongata. Ectoine is hydrolysed by DoeA to alpha-N-acetyl diaminobutyric acid which is then deacetylated to diaminobutyric acid by DoeB .
ESX-1 secretion-associated protein EspA/EspE-like (ESX-1_EspA/EspE-like)
Type: Domain

This entry represents a domain found in actinobacterial proteins, including EspA and EspE from Mycobacteria.

The ESX-1 operon is present in a number of Mycobacteria strains . In Mycobacterium tuberculosis (Mtb) the type VII ESX-1 secretion apparatus is used to translocate the key virulence factors EsxA (ESAT-6) and EsxB (CFP-10).

In Mtb, the EspA protein is encoded by the unlinked espACD operon . The EspA protein of Mycobacterium tuberculosis is essential for the type VII ESX-1 protein secretion apparatus . EspA, ESAT-6, and CFP-10 are each critical for virulence of pathogenic mycobacteria and secretion of these three proteins, is mutually dependent . EspA undergoes Cys138-mediated homodimerization, although the process is not required for EspA or ESAT-6 secretion .

EspE is encoded by the ESX-1 operon . In M. smegmatis it has been shown to colocalise with SaeC at, or near, the cell pole . In M. smegmatis secretion of the heterodimer of EsxAB (ESAT-6/CFP-10) is dependent on the co-secretion of proteins encoded from both esx1 (eg., EspE) and non-esx1 genes (eg., EspA) .
6-phospho-N-acetylmuramidase, N-terminal (MupG_N)
Type: Domain

This entry represents the N-terminal domain of 6-phospho-N-acetylmuramidase from bacteria. MupG is involved in the recycling pathway of the cell wall turnover product MurNAc-GlcNAc in S.aureus. It catalyses the hydrolysis of MurNAc 6-phosphate-GlcNAc, the disaccharide product of MurP-uptake and phosphorylation, yielding MurNAc 6-phosphate and GlcNAc . These proteins appear to consist of two structural subdomains as it can be seen in the two available crystal structures of Enterococcus faecalis (

) and Bacillus cereus (

). This is the larger N-terminal domain with a TIM-barrel like structure and the C-terminal domain is similar to the cyclophilin family.
Domain of unknown function DUF5737 (DUF5737)
Type: Domain

This entry represents a domain of unknown function found in various Platyhelminthes.
Domain of unknown function DUF5738 (DUF5738)
Type: Domain

This entry represents a domain of unknown function found in various Platyhelminthes.
Domain of unknown function DUF5739 (DUF5739)
Type: Domain

This entry represents a domain of unknown function found in various Platyhelminthes.
Domain of unknown function DUF5740 (DUF5740)
Type: Domain

This domain of unknown function is found in proteins from Platyhelminthes, including proteins annotated as death-domain containing proteins.
Domain of unknown function DUF5872 (DUF5872)
Type: Domain

This is a domain found in a family of uncharacterised proteins of unknown function predominantly found in viruses and Bacteria.
Protein of unknown function DUF5871 (DUF5871)
Type: Family

This is a family of uncharacterised proteins of unknown function predominantly found in Phycodnaviridae.
Uracil-DNA glycosylase inhibitor (Ugi)
Type: Family

This family includes the Uracil-DNA glycosylase inhibitor (Ugi) found in Bacillus subtilis phage. Ugi is an inhibitor that inactivates the host uracil-DNA glycosylase (UDG), also known as (UNG) uracil-DNA N-glycosylase. UDG is a highly conserved enzyme responsible for the initiation of uracil-base excision repair . Ugi forms a tight non-covalent bond to UDG, completely inhibiting it from binding to DNA by inserting its β1 strand into the conserved DNA-binding groove of the enzyme . In complex with UDG, Ugi folds into an α-β-α sandwich structure formed by five-stranded antiparallel β-strands and two helices .
Protein of unknown function DUF5870 (DUF5870)
Type: Family

This entry represents uncharacterised proteins of unknown function found in Pandoraviruses.
Domain of unknown function DUF5869 (DUF5869)
Type: Domain

This is a domain of unknown function found in uncharacterised proteins predominately from Marseilleviridae.
Protein of unknown function DUF5790 (DUF5790)
Type: Family

This is a family of proteins of unknown function found, predominantly, in Halobacteria.
Protein of unknown function DUF5791 (DUF5791)
Type: Family

This is a family of proteins of unknown function predominantly found in Halobacteria.
Protein of unknown function DUF5792 (DUF5792)
Type: Family

Proteins in this family can be found in prasinoviruses.
Protein of unknown function DUF5793 (DUF5793)
Type: Family

This is a family of proteins of unknown function predominantly found in Halobacteria.
Protein of unknown function DUF5794 (DUF5794)
Type: Family

This is a family of proteins of unknown function predominantly found in Halobacteria.
Protein of unknown function DUF5795 (DUF5795)
Type: Family

Proteins in this family are predominantly found in Halobacteria.
Protein of unknown function DUF5796 (DUF5796)
Type: Family

This is a family of proteins of unknown function predominantly found in Halobacteria.
Protein of unknown function DUF5797 (DUF5797)
Type: Family

This is a family of proteins of unknown function predominantly found in Halobacteria.
Protein of unknown function DUF5798 (DUF5798)
Type: Family

DUF5798 is a family of unknown function predominantly found in Halobacteria.
Protein of unknown function DUF5799 (DUF5799)
Type: Family

This is a family of proteins of unknown function predominantly found in Halobacteria.
EsV-1-7 cysteine-rich motif (EsV_1_7_cys)
Type: Repeat

The EsV-1-7 repeat is a cysteine-rich motif of unknown function. The motif was originally identified in the Ectocarpus "immediate upright" protein, which has an EsV-1-7 domain that contains five EsV-1-7 repeats . The name is derived from the Ectocarpus virus EsV-1 protein EsV-1-7, which possesses six EsV-1-7 repeats. Ectocarpus has a large family of EsV-1-7 domain proteins with between one and 19 copies of the motif (C-X4-C-X16-C-X2-H-X12). In addition to brown algae, EsV-1-7 domain proteins have been found in eustigmatophytes, oomycetes, cryptophytes, two families of green algae (Coccomyxaceae and Selenastraceae) and also in viral genomes, such as Emiliania huxleyi virus PS401 and Pithovirus sibericum. Based on this unusual distribution, it has been proposed that EsV-1-7 domain genes have been exchanged between lineages by horizontal gene transfer during evolution .
Protein of unknown function DUF5800 (DUF5800)
Type: Family

This is a family of proteins of unknown function predominantly found in Halobacteria.
Domain of unknown function DUF5801 (DUF5801)
Type: Domain

This entry contains a presumed domain that is found as tandem repeats in a number of bacterial proteins. The domain is rich in negatively charged amino acids and contains multiple potential calcium binding sites.
Protein of unknown function DUF5802 (DUF5802)
Type: Family

DUF5802 is a family of unknown function predominantly found in Halobacteria.
Protein of unknown function DUF5803 (DUF5803)
Type: Family

DUF5803 is a family of unknown function predominantly found in Halobacteria and Methanomicrobia.
Protein of unknown function DUF5804 (DUF5804)
Type: Family

This is a family of unknown function predominantly found in Halobacteria and Methanomicrobia.
Protein of unknown function DUF5805 (DUF5805)
Type: Family

This is a family of proteins of unknown function predominantly found in Halobacteria.
Protein of unknown function DUF5806 (DUF5806)
Type: Family

This is a family of proteins of unknown function predominantly found in Halobacteria and Methanomicrobia.
Protein of unknown function DUF5807 (DUF5807)
Type: Family

This is a family of proteins of unknown function found in Halobacteria.
Domain of unknown function DUF5808 (DUF5808)
Type: Domain

Proteins containing this domain can be found in bacteria and archaea. The function of this domain is not clear.
Protein of unknown function DUF5809 (DUF5809)
Type: Family

This is a family of proteins of unknown function predominantly found in Halobacteria.
Protein of unknown function DUF5810 (DUF5810)
Type: Family

This is a family of proteins of unknown function predominantly found in Halobacteria.
Response receiver domain (REC)
Type: Domain

Two-component systems (TCS) are widespread signal sensing and transduction machineries found mainly in bacteria and archaea, but can be also found in yeasts and plants. They comprise a homodimeric histidine kinase (HK) bound to the membrane that contains an extracellular sensor domain, and a response regulator (RR) that triggers the response modifying target genes expression. The signal transduction implies the ATP-dependent phosphorylation of a His residue present in the dimerisation and histidine phosphotransfer HK domain (DHp). The C-terminal catalytic domain (CA, also known as HATPase_c) binds ATP and phosphorylates the His residue. Then, the phosphoryl group in the His is transferred to an Asp present in a RR domain called the receiver domain (REC), which induces conformational changes of RR and modulates the affinity of an effector domain. In cases which lack an effector domain, the REC domain takes over that role .

This entry represents the receiver domain (REC) that, together with Histidine kinase (HK), constitutes the TCS system .
Protein of unknown function DUF5811 (DUF5811)
Type: Family

This is a family of proteins of unknown function predominantly found in Halobacteria.
Dimerisation and histidine phosphotransfer (DHp) domain (DHp)
Type: Domain

Two-component systems (TCS) are widespread signal sensing and transduction machineries found mainly in bacteria and archaea, but can be also found in yeasts and plants. They comprise a homodimeric histidine kinase (HK) bound to the membrane that contains an extracellular sensor domain, and a response regulator (RR) that triggers the response modifying target genes expression. The signal transduction implies the ATP-dependent phosphorylation of a His residue present in the dimerisation and histidine phosphotransfer HK domain (DHp). The C-terminal catalytic domain (CA, also known as HATPase_c) binds ATP and phosphorylates the His residue. Then, the phosphoryl group in the His is transferred to an Asp present in a RR domain called the receiver domain (REC), which induces conformational changes of RR and modulates the affinity of an effector domain. In cases which lack an effector domain, the REC domain takes over that role .

This entry represents the dimerisation and histidine phosphotransfer (DHp) domain found in Histidine kinases (HK).
Mtf2-like, C-terminal domain (Mtf2-like_C)
Type: Domain

Unlike mammalian mitochondrial DNAs (mtDNA), yeasts mtDNAs have introns. This entry represents the C-terminal region of Mtf2 from S. cerevisiae and its homologue in S. pombe, C5D6.12, although they share weak amino acid sequence similarity. Mtf2 from S. cerevisiae is required for overall mitochondrial protein synthesis, whereas the S. pombe counterpart has a more limited role, as it is required for cox1 gene expression .
Adhesion G protein-coupled receptor B, N-terminal domain (AGRB_N)
Type: Domain

This entry represents a region found at the N-terminal of various adhesion G-protein coupled receptor B proteins (AGRB), also known as Brain-specific angiogenesis inhibitors (BAIs), involved in cell adhesion and probably in cell-cell interactions. AGRBs are most abundantly expressed in brain tissue playing an important role in synapses, however, they are also found in other tissues such as heart, thymus and skeletal muscle . The The N-terminal domain of these receptors has an inhibitory effect on the constitutive signalling activity and is required to be removed to increase its activity
PafC, HTH domain (PafC_HTH)
Type: Domain

This entry represents the N-terminal helix-turn-helix DNA-binding domain from the proteasome accessory factor C (PafC), which upregulates most of the genes induced by DNA damage. It mediates protein-DNA interactions as well as protein-protein interactions. The conformation of HTH exerts a regulatory mechanism, which prevents PafBC from efficient DNA binding under normal conditions .
Protein of unknown function DUF5868 (DUF5868)
Type: Family

This is a family of uncharacterised proteins of unknown function predominantly found in Mimiviridae.
Domain of unknown function DUF5867 (DUF5867)
Type: Domain

This domain of unknown function is found in pandoraviruses proteins.
Domain of unknown function DUF5866 (DUF5866)
Type: Domain

This is a domain of unknown function predominantly found in Mimiviridae proteins.
Domain of unknown function DUF5865 (DUF5865)
Type: Domain

This entry represents a domain of unknown function present in hypothetical pandoraviruses proteins.
Protein of unknown function DUF5864 (DUF5864)
Type: Family

This is a family of uncharacterised proteins of unknown function predominantly found in Mimiviridae.
Protein of unknown function DUF5863 (DUF5863)
Type: Family

This entry represents proteins of unknown function predominantly found in Betabaculoviruses.
Domain of unknown function DUF5862 (DUF5862)
Type: Domain

This domain of unknown function found in proteins from viruses and bacteria.
Domain of unknown function DUF5860 (DUF5860)
Type: Domain

This domain is found in uncharacterised proteins predominantly from pandoraviruses.
Protein of unknown function DUF5859 (DUF5859)
Type: Family

This family of proteins represents uncharacterised proteins of unknown function predominantly found in Mimiviridae.
Protein of unknown function DUF5812 (DUF5812)
Type: Family

Proteins in this family are predominantly found in Halobacteria.
Protein of unknown function DUF5813 (DUF5813)
Type: Family

Proteins in this family are predominantly found in Halobacteria.
Protein of unknown function DUF5814 (DUF5814)
Type: Family

This is a family of proteins that are thought to have helicase activity, predominantly found in Halobacteria and Methanomicrobia.
Protein of unknown function DUF5815 (DUF5815)
Type: Family

Proteins in this family are predominantly found in Halobacteria.
Protein of unknown function DUF5816 (DUF5816)
Type: Family

This is a family of proteins predominantly found in Halobacteria. They are thought to be GNAT (Gcn5-related N-acetyltransferases) family acetyltransferases.
Domain of unknown function DUF5817 (DUF5817)
Type: Domain

This entry represents a presumed domain found at the N-terminal of a family of proteins predominantly found in Halobacteria. These proteins are thought to be the replication protein H.
Protein of unknown function DUF5818 (DUF5818)
Type: Family

This is a group of uncharacterised bacterial proteins.
Protein of unknown function DUF5819 (DUF5819)
Type: Family

This is a group of uncharacterised bacterial proteins.
Protein of unknown function DUF5820 (DUF5820)
Type: Family

Proteins in this family are predominantly found in Halobacteria.
Transcriptional regulator TbsP, N-terminal domain (TbsP-like_N)
Type: Domain

This entry represents the N-terminal domain of the putative transcriptional regulator TbsP (TrmB suppressor, or "tablespoon") from Halobacterium volcanii (HVO_2861,

) and similar sequences predominantly found in Halobacteria. TbsP is required for adhesion to abiotic surfaces (i.e., biofilm formation) and maintains wild-type cell morphology and motility. It is predicted to have a C-terminal MarR-type helix-turn-helix (HTH) DNA- binding domain .
Protein of unknown function DUF5822 (DUF5822)
Type: Family

This is a family of proteins of unknown function predominantly found in Halobacteria. This family includes some members which are thought to be peptidoglycan binding proteins.
Protein of unknown function DUF5823 (DUF5823)
Type: Family

This is a group of uncharacterised bacterial proteins.
Domain of unknown function DUF5824 (DUF5824)
Type: Domain

This family contains a domain of unknown function, which is predominantly found in Algavirales and Caudovirales proteins. This domain is also found in bacterial proteins.
Protein of unknown function DUF5825 (DUF5825)
Type: Family

This is a group of uncharacterised bacterial proteins.
OMP85-like, membrane spanning beta-barrel domain (Omp85-like_dom)
Type: Domain

This entry represents the membrane spanning β-barrel domain of various Omp85 superfamily related proteins that have often have POTRA and Patatin domains.
Protein of unknown function DUF5826 (DUF5826)
Type: Family

Proteins in this family are mostly found in prasinoviruses and are likely to be membrane proteins with two transmembrane regions.
E3 ubiquitin-protein ligase TTC3/DZIP3 domain (TTC3/DZIP3_dom)
Type: Domain

This domain is found in E3 ubiquitin-protein ligase TTC3 and DZIP3, its function is unknown.

TTC3 mediates ubiquitination and degradation of phosphorylated Akt, which seems to be its preferable target .

DZIP3 is able to bind RNA through a Lys-rich region, which enhances its ubiquitination activity. It is suggested that RNA-binding proteins or ribonucleoprotein particles (RNPs) might be physiological targets for this enzyme, which could be important during viral infections as the ubiquitin process also mediates virus budding, especially for those replicating through RNA intermediates .
Protein of unknown function DUF5827 (DUF5827)
Type: Family

This is a family of proteins of unknown function predominantly found in Halobacteria.
Protein of unknown function DUF5828 (DUF5828)
Type: Family

This is a family of proteins of unknown function predominantly found in Halobacteria.
Protein of unknown function DUF5829 (DUF5829)
Type: Family

This is a group of uncharacterised bacterial proteins.
Protein of unknown function DUF5830 (DUF5830)
Type: Family

This is a family of proteins predominantly found in Halobacteria. Some members includes the MarR family transcriptional regulator.
Protein of unknown function DUF5831 (DUF5831)
Type: Family

Proteins in this family are found mostly in Bamfordvirae.
Protein of unknown function DUF5832 (DUF5832)
Type: Family

This entry contains proteins of unknown function mostly found in virus.
Domain of unknown function DUF5858 (DUF5858)
Type: Domain

This is a domain of unknown function found in uncharacterised proteins predominately from Marseilleviridae.
Protein of unknown function DUF5834 (DUF5834)
Type: Family

This entry represents an uncharacterised protein associated with the thiocillin biosynthetic gene cluster.
Domain of unknown function DUF5857 (DUF5857)
Type: Domain

This is a domain of unknown function found in membrane proteins from viruses.
Protein of unknown function DUF5856 (DUF5856)
Type: Family

This is a family of uncharacterised proteins of unknown function predominantly found in viruses. This family was also found in Bacteria.
Domain of unknown function DUF5855 (DUF5855)
Type: Domain

This entry represents a domain found in viral inclusion proteins of unknown function from Phycodnaviridae.
Protein of unknown function DUF5854 (DUF5854)
Type: Family

This is a family of uncharacterised proteins of unknown function predominantly found in Mimiviridae.
Domain of unknown function DUF5853 (DUF5853)
Type: Domain

This is a domain of unknown function found in chloroviruses.
Protein of unknown function DUF5852 (DUF5852)
Type: Family

This is a family of uncharacterised proteins of unknown function found in ranaviruses.
Protein of unknown function DUF5851 (DUF5851)
Type: Family

This is a family of uncharacterised proteins of unknown function predominantly found in Mimiviridae.
Protein of unknown function DUF5850 (DUF5850)
Type: Family

This is a family of uncharacterised proteins found in Iridoviridae. These proteins possess a conserved motif towards the C-terminal, containing a central RGD sequence, which suggests that these viral proteins may bind to integrins.
Protein of unknown function DUF5849 (DUF5849)
Type: Family

This is a family of uncharacterised proteins of unknown function found in pandoraviruses.
Domain of unknown function DUF5848 (DUF5848)
Type: Domain

The function of this domain is unknown, it appears to be restricted to pandoraviruses.
Protein of unknown function DUF5847 (DUF5847)
Type: Family

This is a family of uncharacterised proteins of unknown function predominantly found in Mimiviridae.
Protein of unknown function DUF5846 (DUF5846)
Type: Family

This is a family of uncharacterised proteins of unknown function predominantly found in Mimiviridae.
Protein of unknown function DUF5845 (DUF5845)
Type: Family

This family of uncharacterised proteins of unknown function is mainly found in Mimiviridae and Marseilleviridae.
Protein of unknown function DUF5844 (DUF5844)
Type: Family

This is a family of uncharacterised proteins found in Iridoviridae. Its function is unknown.
Protein of unknown function DUF5843 (DUF5843)
Type: Family

This is a family of uncharacterised proteins predominantly found in viruses.
SPARK domain (SPARK)
Type: Domain

This entry represents an extracellular domain of plant receptor-like kinases (SIMILAR PROTEIN TO ARK, SPARK), many of which play a role in signalling during plant-fungal symbiosis. The precise function of this domain is unknown (Montero H et. al., PNAS June 22, 2021 118 (25) e2105281118; https://doi.org/10.1073/pnas.2105281118).
Protein of unknown function DUF5841 (DUF5841)
Type: Family

This is a family of proteins of unknown function from Enterococcus associated with the biosynthetic gene cluster for enterocin A.
6-phospho-N-acetylmuramidase, C-terminal (MupG_C)
Type: Domain

This entry represents the C-terminal domain of 6-phospho-N-acetylmuramidase found in bacteria. MupG is involved in the recycling pathway of the cell wall turnover product MurNAc-GlcNAc in S. aureus. It catalyses the hydrolysis of MurNAc 6-phosphate-GlcNAc, the disaccharide product of MurP-uptake and phosphorylation, yielding MurNAc 6-phosphate and GlcNAc . These proteins appear to consist of two structural subdomains as it can be seen in the two available crystal structures of Enterococcus faecalis (

) and Bacillus cereus (

). The larger N-terminal domain has a TIM-barrel like structure, while this C-terminal domain is similar to the cyclophilin family.
Protein of unknown function DUF5839 (DUF5839)
Type: Family

This entry represents a family of uncharacterised proteins of unknown function associated with the biosynthetic gene cluster for glycocin F. The family appears to be restricted to Firmicutes.
AbpIP induction peptide (AbpIP)
Type: Family

This family represents the induction peptide AbpIP, which regulates the biosynthesis of the bacteriocin ABP-118 in Lactobacillus salivarius subsp. salivarius UCC118 .
Protein of unknown function DUF5835 (DUF5835)
Type: Family

This entry represents a family of uncharacterised proteins of unknown function found in Lactobacillus salivarius. It is associated with the biosynthetic gene cluster for the bacteriocin salivaricin CRL 1328, which is similar to the gene cluster for the bacteriocin ABP118 .
FANCL, UBC-like domain 2 (FANCL_d2)
Type: Domain

This entry represents the second of three UBC-like domains found in the FANCL protein, which is the catalytic E3 ubiquitin ligase subunit of the FA complex (Fanconi anaemia). Eight subunits encoded by the Fanconi anaemia gene products form a multisubunit nuclear complex which is required for mono-ubiquitination of a downstream FA protein, FANCD2 .
Protein of unknown function DUF5789 (DUF5789)
Type: Family

This is a family of proteins of unknown function predominantly found in Halobacteria.
Protein of unknown function DUF5788 (DUF5788)
Type: Family

This is a family of uncharacterised proteins of unknown function found in Halobacteria and Methanomicrobia.
Protein of unknown function DUF5787 (DUF5787)
Type: Family

This is a family of proteins of unknown function predominantly found in Halobacteria.
Domain of unknown function DUF5786 (DUF5786)
Type: Domain

This entry represents a domain found in uncharacterised proteins from Halobacteria. Its function is unknown.