SII-SWORD/CoKE huggingface dataset:
Nuclear SET domain-containing protein 2, SET domain (SET_NSD2)
Type: Domain

This entry represents the SET domain (including post-SET domain) of NSD2 and similar sequences from vertebrates.

Histone-lysine N-methyltransferase NSD2, also known as Nuclear SET domain-containing protein 2 or wolf-Hirschhorn syndrome candidate 1 protein (WHSC1), is overexpressed frequently in the t(4;14) translocation in 15% to 20% of multiple myeloma . It plays important roles in cancer cell proliferation, survival, and tumour growth, through mediating constitutive NF-kappaB signalling via the cytokine autocrine loop . It also enhances androgen receptor (AR)-mediated transcription . The principal chromatin-regulatory activity of NSD2 is dimethylation of histone H3 at lysine 36 (H3K36me2). NSD2 is highly overexpressed in several types of human cancers, including small-cell lung cancers, neuroblastoma, carcinomas of stomach and colon, and bladder cancers, and its overexpression tends to be associated with tumour aggressiveness . It is frequently deleted in Wolf-Hirschhorn syndrome. NSD2 contains a catalytic suppressor of variegation, enhancer of zeste and trithorax (SET) domain, two proline-tryptophan-tryptophan-prolin motif (PWWP) domains, a high mobility group (HMG) box, five PHD (plant-homeodomain) zinc finger motifs, and an NSD-specific Cys-His rich domain (C5HCH). The SET domain is responsible for histone methyltransferase activity. The PWWP, HMG, and PHD domains mediate chromatin interaction and recognition of histone marks.
Fragile X messenger ribonucleoprotein 1, first type I K homology domain (KH_I_FMR1_rpt1)
Type: Domain

This entry represents the first KH domain of FMR1, also known as KH0, which is a divergent KH domain that lacks the RNA-binding GXXG motif.

Fragile X messenger ribonucleoprotein 1 (FMRP/FMR1), and its paralogues, FXR1 and FXR2 (RNA-binding protein FXR1 and 2, respectively), comprise a family of RNA-binding proteins . These are multifunctional polyribosome-associated proteins that play a central role in neuronal development and synaptic plasticity. They are involved in regulation of alternative mRNA splicing, mRNA stability, mRNA dendritic transport and postsynaptic local protein synthesis of a subset of mRNAs . They are highly similar to one another and also retain highly conserved domain architecture comprising two tandem Tudor Agenet-like domains at the N-terminal, three ribonucleoprotein K homology (KH) domains and a cluster of arginine and glycine residues that constitute the RGG box .

FMR1 performs nucleocytoplasmic shuttling of mRNA by a non-canonical nuclear localization signal (NLS) and a nuclear export signal . This protein plays a central role in neuronal development and synaptic plasticity and is able to modulate the DNA damage response. It is also required for ovary development and function . FMR1 has also been shown to interact with components of the miRNA pathway . A large expansion of the CGG trinucleotide repeat in the 5'-untranslated region of the FMR1 gene causes Fragile X syndrome (FXS), an inherited developmental disorder that causes a broad range of intellectual and physical challenges .
Nuclear SET domain-containing protein 2, second PHD finger (PHD2_NSD2)
Type: Domain

This entry represents the second PHD finger found in NSD2 and similar sequences from vertebrates.

Histone-lysine N-methyltransferase NSD2, also known as Nuclear SET domain-containing protein 2 or wolf-Hirschhorn syndrome candidate 1 protein (WHSC1), is overexpressed frequently in the t(4;14) translocation in 15% to 20% of multiple myeloma . It plays important roles in cancer cell proliferation, survival, and tumour growth, through mediating constitutive NF-kappaB signalling via the cytokine autocrine loop . It also enhances androgen receptor (AR)-mediated transcription . The principal chromatin-regulatory activity of NSD2 is dimethylation of histone H3 at lysine 36 (H3K36me2). NSD2 is highly overexpressed in several types of human cancers, including small-cell lung cancers, neuroblastoma, carcinomas of stomach and colon, and bladder cancers, and its overexpression tends to be associated with tumour aggressiveness . It is frequently deleted in Wolf-Hirschhorn syndrome. NSD2 contains a catalytic suppressor of variegation, enhancer of zeste and trithorax (SET) domain, two proline-tryptophan-tryptophan-prolin motif (PWWP) domains, a high mobility group (HMG) box, five PHD (plant-homeodomain) zinc finger motifs, and an NSD-specific Cys-His rich domain (C5HCH). The SET domain is responsible for histone methyltransferase activity. The PWWP, HMG, and PHD domains mediate chromatin interaction and recognition of histone marks.
Fragile X messenger ribonucleoprotein 1, second type I K homology domain (KH_I_FMR1_rpt2)
Type: Domain

This entry represents the second KH domain of FMR1 and similar proteins from vertebrates.

Fragile X messenger ribonucleoprotein 1 (FMRP/FMR1), and its paralogues, FXR1 and FXR2 (RNA-binding protein FXR1 and 2, respectively), comprise a family of RNA-binding proteins . These are multifunctional polyribosome-associated proteins that play a central role in neuronal development and synaptic plasticity. They are involved in regulation of alternative mRNA splicing, mRNA stability, mRNA dendritic transport and postsynaptic local protein synthesis of a subset of mRNAs . They are highly similar to one another and also retain highly conserved domain architecture comprising two tandem Tudor Agenet-like domains at the N-terminal, three ribonucleoprotein K homology (KH) domains and a cluster of arginine and glycine residues that constitute the RGG box .

FMR1 performs nucleocytoplasmic shuttling of mRNA by a non-canonical nuclear localization signal (NLS) and a nuclear export signal . This protein plays a central role in neuronal development and synaptic plasticity and is able to modulate the DNA damage response. It is also required for ovary development and function . FMR1 has also been shown to interact with components of the miRNA pathway . A large expansion of the CGG trinucleotide repeat in the 5'-untranslated region of the FMR1 gene causes Fragile X syndrome (FXS), an inherited developmental disorder that causes a broad range of intellectual and physical challenges .
Nuclear SET domain-containing protein 2, third PHD finger (PHD3_NSD2)
Type: Domain

This entry represents the third PHD finger found in NSD2 and similar sequences from vertebrates.

Histone-lysine N-methyltransferase NSD2, also known as Nuclear SET domain-containing protein 2 or wolf-Hirschhorn syndrome candidate 1 protein (WHSC1), is overexpressed frequently in the t(4;14) translocation in 15% to 20% of multiple myeloma . It plays important roles in cancer cell proliferation, survival, and tumour growth, through mediating constitutive NF-kappaB signalling via the cytokine autocrine loop . It also enhances androgen receptor (AR)-mediated transcription . The principal chromatin-regulatory activity of NSD2 is dimethylation of histone H3 at lysine 36 (H3K36me2). NSD2 is highly overexpressed in several types of human cancers, including small-cell lung cancers, neuroblastoma, carcinomas of stomach and colon, and bladder cancers, and its overexpression tends to be associated with tumour aggressiveness . It is frequently deleted in Wolf-Hirschhorn syndrome. NSD2 contains a catalytic suppressor of variegation, enhancer of zeste and trithorax (SET) domain, two proline-tryptophan-tryptophan-prolin motif (PWWP) domains, a high mobility group (HMG) box, five PHD (plant-homeodomain) zinc finger motifs, and an NSD-specific Cys-His rich domain (C5HCH). The SET domain is responsible for histone methyltransferase activity. The PWWP, HMG, and PHD domains mediate chromatin interaction and recognition of histone marks.
Nuclear SET domain-containing protein 2, fifth PHD finger (PHD5_NSD2)
Type: Domain

This entry represents the fifth PHD finger found in NSD2 and similar sequences from vertebrates.

Histone-lysine N-methyltransferase NSD2, also known as Nuclear SET domain-containing protein 2 or wolf-Hirschhorn syndrome candidate 1 protein (WHSC1), is overexpressed frequently in the t(4;14) translocation in 15% to 20% of multiple myeloma . It plays important roles in cancer cell proliferation, survival, and tumour growth, through mediating constitutive NF-kappaB signalling via the cytokine autocrine loop . It also enhances androgen receptor (AR)-mediated transcription . The principal chromatin-regulatory activity of NSD2 is dimethylation of histone H3 at lysine 36 (H3K36me2). NSD2 is highly overexpressed in several types of human cancers, including small-cell lung cancers, neuroblastoma, carcinomas of stomach and colon, and bladder cancers, and its overexpression tends to be associated with tumour aggressiveness . It is frequently deleted in Wolf-Hirschhorn syndrome. NSD2 contains a catalytic suppressor of variegation, enhancer of zeste and trithorax (SET) domain, two proline-tryptophan-tryptophan-prolin motif (PWWP) domains, a high mobility group (HMG) box, five PHD (plant-homeodomain) zinc finger motifs, and an NSD-specific Cys-His rich domain (C5HCH). The SET domain is responsible for histone methyltransferase activity. The PWWP, HMG, and PHD domains mediate chromatin interaction and recognition of histone marks.
Nuclear SET domain-containing protein 2, HMG box (HMG-box_NSD2)
Type: Domain

This entry represents the high mobility group (HMG)-box found in NSD2 and similar sequences from vertebrates.

Histone-lysine N-methyltransferase NSD2, also known as Nuclear SET domain-containing protein 2 or wolf-Hirschhorn syndrome candidate 1 protein (WHSC1), is overexpressed frequently in the t(4;14) translocation in 15% to 20% of multiple myeloma . It plays important roles in cancer cell proliferation, survival, and tumour growth, through mediating constitutive NF-kappaB signalling via the cytokine autocrine loop . It also enhances androgen receptor (AR)-mediated transcription . The principal chromatin-regulatory activity of NSD2 is dimethylation of histone H3 at lysine 36 (H3K36me2). NSD2 is highly overexpressed in several types of human cancers, including small-cell lung cancers, neuroblastoma, carcinomas of stomach and colon, and bladder cancers, and its overexpression tends to be associated with tumour aggressiveness . It is frequently deleted in Wolf-Hirschhorn syndrome. NSD2 contains a catalytic suppressor of variegation, enhancer of zeste and trithorax (SET) domain, two proline-tryptophan-tryptophan-prolin motif (PWWP) domains, a high mobility group (HMG) box, five PHD (plant-homeodomain) zinc finger motifs, and an NSD-specific Cys-His rich domain (C5HCH). The SET domain is responsible for histone methyltransferase activity. The PWWP, HMG, and PHD domains mediate chromatin interaction and recognition of histone marks.
TDRD6, first Tudor domain (Tudor_TDRD6_rpt1)
Type: Domain

This is the first Tudor domain of TDRD6 and similar proteins mainly from mammals.

TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localised to the chromatoid bodies in germ cells, and is involved in spermatogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression . Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality . TDRD6 contains seven Tudor domains.
TDRD6, second Tudor domain (Tudor_TDRD6_rpt2)
Type: Domain

This is the second Tudor domain of TDRD6 and similar proteins, mainly from vertebrates.

TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localised to the chromatoid bodies in germ cells, and is involved in spermatogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression . Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality . TDRD6 contains seven Tudor domains.
TDRD6, fourth Tudor domain (Tudor_TDRD6_rpt4)
Type: Domain

This is the fourth Tudor domain of TDRD6 and similar proteins from primates.

TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localised to the chromatoid bodies in germ cells, and is involved in spermatogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression . Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality . TDRD6 contains seven Tudor domains.
TDRD6, third Tudor domain (Tudor_TDRD6_rpt3)
Type: Domain

This is the third Tudor domain of TDRD6 and similar proteins from primates.

TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localised to the chromatoid bodies in germ cells, and is involved in spermatogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression . Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality . TDRD6 contains seven Tudor domains.
TDRD7, second Tudor domain (Tudor_TDRD7_rpt2)
Type: Domain

This entry represents the second Tudor domain of TDRD7 and similar proteins from vertebrates.

TDRD7 (also called PCTAIRE2-binding protein, or Tudor repeat associator with PCTAIRE-2 (Trap)) belongs to the evolutionary conserved Tudor domain-containing protein (TDRD) family involved in germ cell development. It is a component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes; it probably acts by binding to specific mRNAs and regulating their translation. It is required for lens transparency during lens development, by regulating translation of genes such as CRYBB3 and HSPB1 in the developing lens . It is also essential for dynamic ribonucleoprotein (RNP) remodelling of chromatoid bodies during spermatogenesis. In mice, TDRD7 together with TDRD1/MTR-1, TDRD5 and TDRD6 forms a ribonucleoprotein complex in the intermitochondrial cements (IMCs) and the chromatoid bodies (CBs) involved in RNA processing for spermatogenesis . TDRD7 is functionally essential for the differentiation of germ cells .

TDRD7 contains three N-terminal LOTUS domains and three Tudor domains at the C-terminal. The LOTUS domain adopts the winged helix-turn-helix fold that may bind RNA .
TDRD7, third Tudor domain (Tudor_TDRD7_rpt3)
Type: Domain

This entry represents the third Tudor domain of TDRD7 and similar proteins from vertebrates.

TDRD7 (also called PCTAIRE2-binding protein, or Tudor repeat associator with PCTAIRE-2 (Trap)) belongs to the evolutionary conserved Tudor domain-containing protein (TDRD) family involved in germ cell development. It is a component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes; it probably acts by binding to specific mRNAs and regulating their translation. It is required for lens transparency during lens development, by regulating translation of genes such as CRYBB3 and HSPB1 in the developing lens . It is also essential for dynamic ribonucleoprotein (RNP) remodelling of chromatoid bodies during spermatogenesis. In mice, TDRD7 together with TDRD1/MTR-1, TDRD5 and TDRD6 forms a ribonucleoprotein complex in the intermitochondrial cements (IMCs) and the chromatoid bodies (CBs) involved in RNA processing for spermatogenesis . TDRD7 is functionally essential for the differentiation of germ cells .

TDRD7 contains three N-terminal LOTUS domains and three Tudor domains at the C-terminal. The LOTUS domain adopts the winged helix-turn-helix fold that may bind RNA .
TDRD15, first Tudor domain (Tudor_TDRD15_rpt1)
Type: Domain

This entry represents the first Tudor domain of human TDRD15 and similar sequences mainly found in vertebrates. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions .

TDRD15 is an uncharacterised Tudor domain-containing protein that contains seven Tudor domains.
Histone-lysine N-methyltransferase NSD3, first PWWP domain (PWWP_NSD3_rpt1)
Type: Domain

This entry represents the first PWWP domain of NSD3 and similar sequences from vertebrates. The PWWP domain specifically recognises DNA and histone methylated lysines.

Nuclear receptor-binding SET domain-containing protein 3 (NSD3), also called histone-lysine N-methyltransferase NSD3 or Wolf-Hirschhorn syndrome candidate 1-like protein 1 (WHSC1L1) , is a lysine methyltransferase encoded by gene NSD3, which is amplified in human breast cancer cell lines . Moreover, translocation resulting in NUP98 fusion to NSD3 leads to the development of acute myeloid leukaemia . NSD3 contributes to tumourigenesis by interacting with bromodomain-containing protein 4 (BRD4), the bromodomain and extraterminal (BET) protein, which is a potential therapeutic target in acute myeloid leukaemia . NSD3 contains a SET, two PWWP domains, five plant-homeodomain (PHD) zinc finger motifs, and an NSD-specific Cys-His rich domain (C5HCH). The SET domain is responsible for histone methyltransferase activity. The PWWP and PHD domains are involved in protein-protein interactions .
TDRD15, second Tudor domain (Tudor_TDRD15_rpt2)
Type: Domain

This entry represents the second Tudor domain of human TDRD15 and similar sequences mainly found in vertebrates. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions .

TDRD15 is an uncharacterised Tudor domain-containing protein that contains seven Tudor domains.
Histone-lysine N-methyltransferase NSD3, second PWWP domain (PWWP_NSD3_rpt2)
Type: Domain

This entry represents the second PWWP domain of NSD3 and similar sequences from vertebrates. The PWWP domain specifically recognises DNA and histone methylated lysines.

Nuclear receptor-binding SET domain-containing protein 3 (NSD3), also called histone-lysine N-methyltransferase NSD3 or Wolf-Hirschhorn syndrome candidate 1-like protein 1 (WHSC1L1) , is a lysine methyltransferase encoded by gene NSD3, which is amplified in human breast cancer cell lines . Moreover, translocation resulting in NUP98 fusion to NSD3 leads to the development of acute myeloid leukaemia . NSD3 contributes to tumourigenesis by interacting with bromodomain-containing protein 4 (BRD4), the bromodomain and extraterminal (BET) protein, which is a potential therapeutic target in acute myeloid leukaemia . NSD3 contains a SET, two PWWP domains, five plant-homeodomain (PHD) zinc finger motifs, and an NSD-specific Cys-His rich domain (C5HCH). The SET domain is responsible for histone methyltransferase activity. The PWWP and PHD domains are involved in protein-protein interactions .
TDRD15, third Tudor domain (Tudor_TDRD15_rpt3)
Type: Domain

This entry represents the third Tudor domain of human TDRD15 and similar sequences mainly found in vertebrates. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions .

TDRD15 is an uncharacterised Tudor domain-containing protein that contains seven Tudor domains.
TDRD15, fourth Tudor domain (Tudor_TDRD15_rpt4)
Type: Domain

This entry represents the fourth Tudor domain of human TDRD15 and similar sequences mainly found in mammals. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions .

TDRD15 is an uncharacterised Tudor domain-containing protein that contains seven Tudor domains.
Histone-lysine N-methyltransferase NSD3, second PHD finger (PHD2_NSD3)
Type: Domain

This entry represents the second PHD finger found in NSD3 and similar sequences from vertebrates.

Nuclear receptor-binding SET domain-containing protein 3 (NSD3), also called histone-lysine N-methyltransferase NSD3 or Wolf-Hirschhorn syndrome candidate 1-like protein 1 (WHSC1L1) , is a lysine methyltransferase encoded by gene NSD3, which is amplified in human breast cancer cell lines . Moreover, translocation resulting in NUP98 fusion to NSD3 leads to the development of acute myeloid leukaemia . NSD3 contributes to tumourigenesis by interacting with bromodomain-containing protein 4 (BRD4), the bromodomain and extraterminal (BET) protein, which is a potential therapeutic target in acute myeloid leukaemia . NSD3 contains a SET, two PWWP domains, five plant-homeodomain (PHD) zinc finger motifs, and an NSD-specific Cys-His rich domain (C5HCH). The SET domain is responsible for histone methyltransferase activity. The PWWP and PHD domains are involved in protein-protein interactions .
TDRD15, seventh Tudor domain (Tudor_TDRD15_rpt7)
Type: Domain

This entry represents the seventh Tudor domain of human TDRD15 and similar sequences from vertebrates. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions .

TDRD15 is an uncharacterised Tudor domain-containing protein that contains seven Tudor domains.
Histone-lysine N-methyltransferase NSD3, fourth PHD finger (PHD4_NSD3)
Type: Domain

This entry represents the fourth PHD finger found in NSD3 and similar sequences from vertebrates.

Nuclear receptor-binding SET domain-containing protein 3 (NSD3), also called histone-lysine N-methyltransferase NSD3 or Wolf-Hirschhorn syndrome candidate 1-like protein 1 (WHSC1L1) , is a lysine methyltransferase encoded by gene NSD3, which is amplified in human breast cancer cell lines . Moreover, translocation resulting in NUP98 fusion to NSD3 leads to the development of acute myeloid leukaemia . NSD3 contributes to tumourigenesis by interacting with bromodomain-containing protein 4 (BRD4), the bromodomain and extraterminal (BET) protein, which is a potential therapeutic target in acute myeloid leukaemia . NSD3 contains a SET, two PWWP domains, five plant-homeodomain (PHD) zinc finger motifs, and an NSD-specific Cys-His rich domain (C5HCH). The SET domain is responsible for histone methyltransferase activity. The PWWP and PHD domains are involved in protein-protein interactions .
TDRD15, sixth Tudor domain (Tudor_TDRD15_rpt6)
Type: Domain

This entry represents the sixth Tudor domain of human TDRD15 and similar sequences from vertebrates. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions .

TDRD15 is an uncharacterised Tudor domain-containing protein that contains seven Tudor domains.
TDRD15, fifth Tudor domain (Tudor_TDRD15_rpt5)
Type: Domain

This entry represents the fifth Tudor domain of human TDRD15 and similar sequences mainly found in vertebrates. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions .

TDRD15 is an uncharacterised Tudor domain-containing protein that contains seven Tudor domains.
Histone-lysine N-methyltransferase NSD3, SET domain (SET_NSD3)
Type: Domain

This entry represents the SET domain (including post-SET domain) of NSD3 and similar sequences from vertebrates.

Nuclear receptor-binding SET domain-containing protein 3 (NSD3), also called histone-lysine N-methyltransferase NSD3 or Wolf-Hirschhorn syndrome candidate 1-like protein 1 (WHSC1L1) , is a lysine methyltransferase encoded by gene NSD3, which is amplified in human breast cancer cell lines . Moreover, translocation resulting in NUP98 fusion to NSD3 leads to the development of acute myeloid leukaemia . NSD3 contributes to tumourigenesis by interacting with bromodomain-containing protein 4 (BRD4), the bromodomain and extraterminal (BET) protein, which is a potential therapeutic target in acute myeloid leukaemia . NSD3 contains a SET, two PWWP domains, five plant-homeodomain (PHD) zinc finger motifs, and an NSD-specific Cys-His rich domain (C5HCH). The SET domain is responsible for histone methyltransferase activity. The PWWP and PHD domains are involved in protein-protein interactions .