SII-SWORD/CoKE huggingface dataset:
Proteasome activator complex subunit 4-like, HEAT repeat-like (HEAT_PSME4)
Type: Domain

This domain is found in Proteasome activator complex subunit 4 (PSME4) and in similar sequences from animals and fungi as well as some uncharacterised proteins from plants. PSME4 is an associated component of the proteasome that specifically recognises acetylated histones and promotes ATP- and ubiquitin -independent degradation of core histones during spermatogenesis and DNA damage response. This protein adopts a dome-like structure composed of HEAT repeat-like modules interconnected through three long loops. This entry represents a region of HEAT repeats that contains a long loop .

This domain is also found in the yeast Proteasome activator BLM10 which has been structurally and mechanistically characterised as a component of the proteasome complex .
OST48, N-terminal domain (OST48_N)
Type: Domain

This is the N-terminal domain of OST48 subunits from animals and plants and the orthologue from yeast Wbp1. This domain is distantly related to the IFT52 N-terminal domain (

).

Members of this entry are involved in asparagine-linked protein glycosylation. In particular, dolichyl-diphosphooligosaccharide-protein glycosyltransferase (DDOST/OST48), also known as oligosaccharyltransferase, transfers the high-mannose sugar GlcNAc(2)-Man(9)-Glc(3) from a dolichol-linked donor to an asparagine acceptor in a consensus Asn-X-Ser/Thr motif in nascent polypeptide chains, the first step in protein N-glycosylation . In most eukaryotes, the DDOST complex is composed of three subunits, which in humans are described as a 48kD subunit, ribophorin I, and ribophorin II. However, the yeast DDOST appears to consist of six subunits (alpha, beta, gamma, delta, epsilon, zeta). The yeast beta subunit is a 45kD polypeptide, previously discovered as the Wbp1 protein, with known sequence similarity to the human 48kD subunit and the other orthologues.
IFT52, GIFT domain (IFT52_GIFT)
Type: Domain

This domain is found in various eukaryotic and prokaryotic intra-flagellar transport proteins involved in gliding motility, as well as in several hypothetical proteins. Intraflagellar transport protein 52 homolog (IFT52) from human is included in this entry, which is essential for anterograde complex integrity and for the biosynthesis and maintenance of cilia . This domain has been described as the GIFT domain in IFT52 whose function is not yet clear .
OST48, middle domain (OST48_MD)
Type: Domain

This entry represents the middle domain (MD) of OST48 from animals and its orthologue from yeast Wbp1 . This domain adopts a β-sandwich fold, which together with the N-terminal domain (

), interacts with riphophorin II/Swp1 subunit .

Members of this entry are involved in asparagine-linked protein glycosylation. In particular, dolichyl-diphosphooligosaccharide-protein glycosyltransferase (DDOST/OST48), also known as oligosaccharyltransferase, transfers the high-mannose sugar GlcNAc(2)-Man(9)-Glc(3) from a dolichol-linked donor to an asparagine acceptor in a consensus Asn-X-Ser/Thr motif in nascent polypeptide chains, the first step in protein N-glycosylation . In most eukaryotes, the DDOST complex is composed of three subunits, which in humans are described as a 48kD subunit, ribophorin I, and ribophorin II. However, the yeast DDOST appears to consist of six subunits (alpha, beta, gamma, delta, epsilon, zeta). The yeast beta subunit is a 45kD polypeptide, previously discovered as the Wbp1 protein, with known sequence similarity to the human 48kD subunit and the other orthologues.
IFT52, central domain (IFT52_central)
Type: Domain

This entry represents the central domain of IFT52 homolog from human and related proteins. IFT52 is a core component of the IFT-B complex which is involved in intraflagellar transport (IFT), the bidirectional movement of particles required for the assembly, maintenance and functioning of primary cilia . IFT52 interacts with IFT88 and IFT70 through the central domain, while its C-terminal domain (

) interacts with IFT46 and IFT74 .
Matrix protein, C-terminal domain, pneumovirus (Matrix_Pneumo_C)
Type: Domain

This entry represents the C-terminal domain of the pneumoviral matrix protein. The C-terminal domain of the RSV M protein (residues 140-255) consists of a flattened β-barrel formed by two 3-stranded antiparallel β-sheets . The regions linking the β-sheets between strands 2 and 3, and strands 5 and 6, are largely α-helical. This domain contains a positively charged pocket that may serve as an interaction site. A striking planar arrangement of conserved tyrosine residues (Y163, Y197, Y215, Y229, Y236, Y237) encircles the domain, suggesting a role in membrane association. Sequence comparisons indicate the C-terminal domain is more conserved among pneumoviruses compared to the N-terminal domain. However, surface-exposed loop regions still represent areas of significant diversity, likely involved in species-specific interactions. The C-terminal domain is loosely tethered to the N-terminal domain by a flexible linker.
Domain of unknown function DUF7034 (DUF7034)
Type: Domain

This domain is found in a group of uncharacterised proteins from Dictyostelia. It is predicted to adopt Ig-like fold with the fibronectin type III-like topology.
Domain of unknown function DUF7035 (DUF7035)
Type: Domain

This domain is found in a group of uncharacterised proteins from Dictyostelia. It is predicted to adopt Ig-like fold with the fibronectin type III-like topology.
Domain of unknown function DUF7036 (DUF7036)
Type: Domain

This entry represents a predicted ferredoxin-like domain found in a family of uncharacterised plant proteins. This group of proteins typically has this domain duplicated.
Domain of unknown function DUF7037 (DUF7037)
Type: Domain

This entry represents a small domain found in a family of uncharacterised proteins in nematodes. This domain is predicted to fold as a β-sheet composed of four anti-parallel β-strands.
Domain of unknown function DUF7038 (DUF7038)
Type: Domain

This entry represents a domain found in a family of uncharacterised proteins in nematodes. In some proteins, this domain appears internally duplicated.
Domain of unknown function DUF7039 (DUF7039)
Type: Domain

This entry represents a domain found in a family of uncharacterised proteins in nematodes.
Domain of unknown function DUF7040 (DUF7040)
Type: Domain

This entry represents a C-terminal domain found in a family of uncharacterised proteins in nematodes.
Domain of unknown function DUF7041 (DUF7041)
Type: Domain

This is a domain of unknown function predominantly found at the N-terminal of sequences from ticks, spiders and similar sequences from arthropods. According to structure predictions this domain may adopt a α-helical bundle fold similar to Ty3 transposon capsid-like proteins.
Domain of unknown function DUF7042 (DUF7042)
Type: Domain

This domain is found in a group of uncharacterised metazoan proteins. It is predicted to adopt a globular structure with lipocalin fold. It also contains several highly conserved cysteine residues that are likely involved in the formation of intra-domain disulfide bridges.
Domain of unknown function DUF7043 (DUF7043)
Type: Domain

This domain is found in a group of uncharacterised metazoan proteins. It is predicted to adopt a globular structure with lipocalin fold. It also contains several highly conserved cysteine residues that are likely involved in the formation of intra-domain disulfide bridges.
Domain of unknown function DUF7044 (DUF7044)
Type: Domain

This domain is found in a group of uncharacterised metazoan proteins. It is predicted to adopt a globular structure with lipocalin fold. It also contains several highly conserved cysteine residues that are likely involved in the formation of intra-domain disulfide bridges.
Domain of unknown function DUF7045 (DUF7045)
Type: Domain

This domain is found in a group of uncharacterised metazoan proteins. It is predicted to adopt a globular structure with lipocalin fold. It also contains several highly conserved cysteine residues that are likely involved in the formation of intra-domain disulfide bridges.
Domain of unknown function DUF7046 (DUF7046)
Type: Domain

This domain is found in a group of uncharacterised plant proteins. These proteins are probably distantly related to the plant-specific actin-binding protein SCAB1 and are predicted to contain a fusion domain composed of Ig and PH-like domains in a similar arrangement as in SCAB1 . The domain represented by this entry, which is often found associated with

, is predicted to fold as an atypical PH-like domain.
Domain of unknown function DUF7047 (DUF7047)
Type: Domain

This is a domain of unknown function mostly found in arthropods. This domain may adopt a three helical bundle fold. These sequences might be related to reverse transcriptase polymerases.
Domain of unknown function DUF7048 (DUF7048)
Type: Domain

This entry represents a domain found in uncharacterised proteins mainly from Trypanosoma sp. According to structural predictions, this domain is likely to adopt a β-propeller fold.
Domain of unknown function DUF7049 (DUF7049)
Type: Domain

This domain is found in a group of uncharacterised proteins mainly from plants. This domain is predicted to fold into a globular structure that adopts a ferredoxin-like fold.
Domain of unknown function DUF7050 (DUF7050)
Type: Domain

This domain is found N-terminal in a group of uncharacterised proteins mainly from plants. It shares a significant sequence similarity with the N-terminal domain of bHLH-MYC and R2R3-MYB transcription factors (Pfam:PF14215) and it is predicted to adopt similar structure.
Domain of unknown function DUF7051 (DUF7051)
Type: Domain

This is a domain of unknown function mostly found in organisms within the Trypanosoma genus. This domain adopt a multiple helical bundle fold.
NAD-dependent glutamate dehydrogenase, N-terminal domain (NAD-GDH_N)
Type: Domain

This domain is found in yeast NAD-specific glutamate dehydrogenase (GDH2, also known as DHE2) and similar fungal proteins. GDH2 is involved in the degradation of glutamate to ammonia and alpha-ketoglutarate.

This domain is found at the N terminus of GDH2 and is predicted to adopt a globular structure composed of four α-helices.
Domain of unknown function DUF7053 (DUF7053)
Type: Domain

This domain is found in a group of uncharacterised proteins mainly from Fungi. It shares significant sequence similarity with domains members of the Bet v1-like superfamily and it is predicted to adopt similar structure.
Domain of unknown function DUF7054 (DUF7054)
Type: Domain

This domain is found in the uncharacterised protein At4g22758 from Arabidopsis thaliana and related proteins. It shares significant sequence similarity with CRIM domain and it is predicted to adopt a similar structure with ubiquitin-like topology.
Domain of unknown function DUF7055 (DUF7055)
Type: Domain

This is a presumed domain found in a group of uncharacterised sequences from bacteria. According to structure predictions, this domain is found at the C-terminal and may adopt an all-β structure consisting of eight anti-parallel β-sheets. These proteins also have a glycosyltransferase domain at the N-terminal (

).
Domain of unknown function DUF7056 (DUF7056)
Type: Domain

This is a presumed domain found in a group of uncharacterised sequences from bacteria. According to structure predictions, this domain is found towards the C-terminal, after a glycosyltransferase domain (

), and it may adopt an α/β structure. In some instances, this domain is followed by and all-β domain at the very C-terminal of the sequences (

). The function of this domain is unknown.
Domain of unknown function DUF7057 (DUF7057)
Type: Domain

This is a presumed domain found at the C-terminal of sequences from Gammaproteobacteria. According to structure predictions it may have an α/β fold.
CUL7/CUL9, N-terminal domain (CUL7/CUL9_N)
Type: Domain

This domain is found N-terminal in the homologues of human Cullin-7 and Cullin-9. It adopts a β-barrel structure with some similarity to chromodomains and is known as a small beta-domain (SBD) . This domain is usually followed by an ARM-like domain.

Cullins are a family of hydrophobic proteins that act as scaffolds for ubiquitin ligases (E3). Cullins are found throughout eukaryotes. Humans express several cullins (Cul1, 2, 3, 4A, 4B, 5, 7 and 9), each forming part of a multi-subunit ubiquitin complex . Cullin-RING ubiquitin ligases (CRLs), such as Cul1 (SCF) , play an essential role in targeting proteins for ubiquitin-mediated destruction; as such, they are diverse in terms of composition and function, regulating many different processes from glucose sensing and DNA replication to limb patterning and circadian rhythms. The catalytic core of CRLs consists of a RING protein and a cullin family member. For Cul1, the C-terminal cullin-homology domain binds the RING protein. The RING protein appears to function as a docking site for ubiquitin-conjugating enzymes (E2s). Other proteins contain a cullin-homology domain, such as the APC2 subunit of the anaphase-promoting complex/cyclosome and the p53 cytoplasmic anchor PARC; both APC2 and PARC have ubiquitin ligase activity. The N-terminal region of cullins is more variable, and is used to interact with specific adaptor proteins .
Domain of unknown function DUF7059 (DUF7059)
Type: Domain

This domain is found N-terminal in a group of uncharacterised bacterial proteins. These proteins are probably distantly related to Aeronamide N-methyltransferases AerE. They share two similar domains that are predicted in the same arrangement. This domain is found N-terminal to the methyltransferase domain and has a weak sequence similarity to various HTH domains.
Domain of unknown function DUF7060 (DUF7060)
Type: Domain

This entry represents a domain found at the C-terminal of a group of proteins from nematodes, members of the BPI/LBP/Plunc family of proteins which share homology with cholesterol ester transfer protein (CETP) and phospholipid transfer protein (PLTP). The exact function of these proteins is unknown, however, according to their structure predictions and homology to CEPT/PLTP, they may play a role in lipid binding.
Domain of unknown function DUF7061 (DUF7061)
Type: Domain

This entry represents a domain found towards the N-terminal of a group of proteins from nematodes such as Trichuris suis and Trichinella britovi, members of the BPI/LBP/Plunc family of proteins which share homology with cholesterol ester transfer protein (CETP) and phospholipid transfer protein (PLTP). The exact function of these proteins is unknown, however, according to their structure predictions and homology to CEPT/PLTP, they may be involved in lipid binding.
Domain of unknown function DUF7062 (DUF7062)
Type: Domain

This domain is found in a group of uncharacterised proteins from digenean species.
Domain of unknown function DUF7063 (DUF7063)
Type: Domain

This is a SH2 domain found mainly in nematodes such as Trichuris trichura, Toxocara canis and Trichinella sp. The function of this domain is unknown.
Domain of unknown function DUF7064 (DUF7064)
Type: Domain

This is a domain of unknown function found in fungi, bacteria and archaea, which, according to structure predictions it adopts a lipocalin-like fold. This domain is found as a pair of two flattened, orthogonally packed, beta-barrels. This entry represents the C-terminal barrel of the pair.
Domain of unknown function DUF7065 (DUF7065)
Type: Domain

This is a domain of unknown function found in fungi and bacteria, which, according to structure predictions it adopts a lipocalin-like fold. This domain is found as a pair of two flattened, orthogonally packed, beta-barrels. This entry represents the N-terminal barrel of the pair. In some members, the lipocalin-like domains (also referred to as AttH-like) are associated with a protein kinase-like domain at the N-terminal (Pfam:PF01636).
Domain of unknown function DUF7066 (DUF7066)
Type: Domain

This is a beta-beta-alpha zinc finger found in a group of uncharacterised sequences, mainly from fungi.
Alpha-glucan water dikinase, DUF7067 (CWD_DUF7067)
Type: Domain

This domain is found in in Alpha-glucan water dikinase (GWD1 and GWD2) from Arabidopsis thaliana and in two-tandem copies in GWD1 from Citrus reticulata and Solanum tuberosum. It is predicted to adopt a globular structure consisting of a three helical bundle. GWD1 is involved in the incorporation of phosphate into starch-like alpha-glucan, mostly at the C-6 position of glucose units . This enzyme acts as regulator of starch mobilization by controlling the phosphate content of starch. The function of the domain represented in this entry is unknown.
Domain of unknown function DUF7068 (DUF7068)
Type: Domain

This domain is found C-terminal to the NTPase domain

in a group of fungal proteins, including

from Sporothrix schenckii. It is predicted to adopt an α-helical configuration.
Domain of unknown function DUF7069 (DUF7069)
Type: Domain

This domain of unknown function is found in a fro up of fungal proteins. It is often N-terminal to several copies of ankyrin repeats. It is predicted to adopt an α-helical configuration.
Domain of unknown function DUF7070 (DUF7070)
Type: Domain

This domain is found in a group of uncharacterised proteins mainly from actinopterygians that are distantly related and share overall similar domain organisation to the human NEDD4-binding protein 1 (N4BP1). This domain shares a weak sequence similarity to known UBA domains and it is predicted to fold into a typical three helical bundle.
Domain of unknown function DUF7071 (DUF7071)
Type: Domain

This domain is found C-terminal in a group of uncharacterised proteins mainly from fungi. It is predicted to adopt a globular structure consisting of two α-helical repeats.
Domain of unknown function DUF7072 (DUF7072)
Type: Domain

This domain is found in a group of uncharacterised proteins mainly from Fungi. It shares a weak sequence similarity to the C-terminal domain of the Escherichia Coli ProQ RNA binding protein (Pfam:PF17516) and it is predicted to adopt a similar structure with SH3-like topology.
Domain of unknown function DUF7073 (DUF7073)
Type: Domain

This domain is found in Histone-lysine N-methyltransferase, H3 lysine-4 specific from Plasmodium falciparum (

) and similar sequences from alveolates. In some proteins this domain is found associated with

. It shows a conserved motif LLxxYKxKI/LxDLL.
Domain of unknown function DUF7074 (DUF7074)
Type: Domain

This domain is found in a group of uncharacterised plant proteins. It is predicted to adopt a globular structure with a Cystatin-like topology consisting of a curved four-stranded β-sheet and an α-helix packed on the concave side of it.
Domain of unknown function DUF7075 (DUF7075)
Type: Domain

This domain is found in a group of uncharacterised plant proteins. It shares a significant sequence similarity with members of the GDP-fucose protein O-fucosyltransferase family (Pfam:PF10250) and it is predicted to adopt similar structure.
Domain of unknown function DUF7076 (DUF7076)
Type: Domain

This domain is found in a group of uncharacterised proteins mainly from fungi. It shares a significant sequence similarity of Ig-like domains found in Trs120 and it is predicted to adopt a structure with a similar topology.
Domain of unknown function DUF7077 (DUF7077)
Type: Domain

This domain is found in a group of uncharacterised proteins mainly from fungi. It shares a weak sequence similarity with the Ig-like domains found in Trs130, particularly the second Ig-like domain, and it is predicted to adopt a structure with a similar topology.
Domain of unknown function DUF7078 (DUF7078)
Type: Domain

This domain is found in uncharacterised proteins mainly from fungi. This domain is predicted to adopt a globular structure consisting of a four helical bundle and having structural similarity to the α-helical domain inserted in the third Ig domain of the Trs130 component of the TRAPPII complex .
Domain of unknown function DUF7079 (DUF7079)
Type: Domain

This is a presumed domain found in a set of bacterial sequences, whose function is unknown.
Domain of unknown function DUF7081 (DUF7081)
Type: Domain

This presumed domain is found in a group of plant sequences related to Oberon-like proteins. According to structure predictions this domain may consist of mainly three β-sheets and two α-helices.
Domain of unknown function DUF7082 (DUF7082)
Type: Domain

This domain is found in uncharacterised proteins mainly from Fungi. This domain is predicted to adopt a globular structure consisting of a curved β-sheet and α-helices packed on it. This domain is probably distantly related to the N-terminal domain of STE-like transcription factors (

) based on the similarity of their predicted structures. The predicted structure of this domain has a partial similarity to pseudo Winged helix domains.
Domain of unknown function DUF7083 (DUF7083)
Type: Domain

This is a presumed domain found at the N-terminal of the uncharacterised protein K02A2.6 from C.elegans and similar worm sequences. This domain may adopt a fold similar to retrotransposons.
Domain of unknown function DUF7084 (DUF7084)
Type: Domain

This domain is found in a group of uncharacterised proteins mainly from Arthropods. This is a relatively small domain that is predicted to contain mainly α-helices.
Domain of unknown function DUF7085 (DUF7085)
Type: Domain

This domain is found in a group of uncharacterised proteins from flatworms. It is predicted to adopt a PH-like fold with similarity to the PH-like domain found in Shulin and Spt16.
Domain of unknown function DUF7086 (DUF7086)
Type: Domain

This domain is found in a group of uncharacterised plant proteins. It is predicted to adopt a globular structure consisting of a rubredoxin-like zinc finger capped with an elaborated α-helical subdomain. This arrangement is similar to the zinc finger domain found in hypA

.
Domain of unknown function DUF7087 (DUF7087)
Type: Domain

This entry represents a four helical integral membrane domain found in nematode species. The function of this domain is unknown.
Protein of unknown function DUF7089 (DUF7089)
Type: Family

This entry represents a family of uncharacterised proteins from halobacteria. Members are predicted to adopt an α-β configuration.
Protein of unknown function DUF7090 (DUF7090)
Type: Family

This entry represents a family of proteins from halobacteria. Members of this family, often annotated as ATPases, are predicted to show a central β-sheet with α-helices in both sides.
Protein of unknown function DUF7091 (DUF7091)
Type: Family

This family represents a group of proteins from halobacteria. It has a conserved motif VCRRH/YAE and conserved R, Y and W residues. Members are predicted to show an α-β configuration.
Domain of unknown function DUF7092 (DUF7092)
Type: Domain

This domain represents a small β-barrel domain that is found at the N terminus of some bacterial peptidase M48 proteins. It has a PH-domain like structure. It likely acts as a chaperone for membrane protein complexes and may interact with

members based on AlphaFold predictions.
Protein of unknown function DUF7093 (DUF7093)
Type: Family

This family represents a group of proteins from halobacteria. It shows two conserved motifs WP and several conserved D and R residues. Members are predicted to show β-sheets at the N- and C-terminal ends.
Domain of unknown function DUF7094 (DUF7094)
Type: Domain

This domain is found in a group of proteins from halobacteria. It shows several Y and Q conserved residues and is predicted to show an antiparallel β-sheet and an α-helix. This entry is found associated with

and

.
Protein of unknown function DUF7095 (DUF7095)
Type: Family

This family represents a group of proteins from halobacteria. They show several highly conserved motifs PVPV, LGL/MDP, AxWA, and PV/IHLEVC. Many members are annotated as nucleotidyltransferases.
Domain of unknown function DUF7096 (DUF7096)
Type: Domain

This domain is found at the N-terminal end of a group of proteins from halobacteria. It is predicted to show a mainly α-configuration. This entry is found associated with

and

.