SII-SWORD/CoKE huggingface dataset:
Domain of unknown function DUF7363 (DUF7363)
Type: Domain

This entry represents a domain of unknown function found in CHAT domain-containing protein, such as SwissProt:A0A100JVW6, from Streptomyces scabiei. This domain may be found in association with TCAD7 (Pfam:PF19973) and CHAT (Pfam:PF12770) domains.
Protein of unknown function DUF7364 (DUF7364)
Type: Family

This entry represents a small uncharacterised family of Pseudomonas phage proteins. Structure prediction suggests that these proteins adopt a pair of α-helices. These proteins are predicted to dimerise to form a four helical bundle. In the predicted dimer there is a short C-terminal β-strand that forms an anti parallel cap at one end of the helical bundle.
Domain of unknown function DUF7365 (DUF7365)
Type: Domain

This entry includes a family of uncharacterised phage proteins that have a predicted N-terminal transmembrane helix and a coiled-coil region. Structure prediction suggests that these proteins may adopt a trimeric coiled-coil structure. Many of these proteins are annotated as holins, however the origin of that annotation is unclear.
Domain of unknown function DUF7366 (DUF7366)
Type: Domain

This entry represents a small uncharacterised domain from Staphylococcus phage. The domain is predicted to be largely composed of small α-helices.
Domain of unknown function DUF7367 (DUF7367)
Type: Domain

This entry represents a small family of uncharacterised phage proteins. These proteins range in length from 94 to 110 amino acids and adopt a small domain composed of four α-helices.
Protein of unknown function DUF7368 (DUF7368)
Type: Family

ThiS entry represents a family of uncharacterised phage proteins.
Domain of unknown function DUF7369 (DUF7369)
Type: Domain

This entry represents a small family of uncharacterised phage proteins. Structure prediction suggests that this protein forms a small domain that likely forms a stable dimeric complex. In this predicted complex there is a C-terminal α-helix that binds to the opposite oligomer in a helix swapped arrangement.
Protein of unknown function DUF7370 (DUF7370)
Type: Family

This entry represents a family of uncharacterised phage proteins. Many of these proteins are annotated as gp11, but the origin of this annotation is unclear. Structure prediction shows this protein adopts an α-helical fold.
Domain of unknown function DUF7371 (DUF7371)
Type: Domain

This domain is found in uncharacterised proteins mainly from fungi. It is predicted to adopt a β-sandwich with similarity to galactose-binding domains.
Domain of unknown function DUF7372 (DUF7372)
Type: Domain

This entry represents a small family of uncharacterised phage proteins. Structure prediction shows the proteins form a compact globular domain composed of a four stranded β-sheet, with a strand order of 4-1-2-3 with an α-helix between strands 3 and 4.
DUF7373, N-terminal (DUF7373)
Type: Domain

This domain is found at the N-terminal of uncharacterised proteins from actinomycetes. It is predicted to adopt a seven-stranded antiparallel β-sheet with similarity to Mog1p/PsbP-like domains. Some proteins containing this domain have a lipoprotein attachment motif at the N-terminal end suggesting they may be associated with the membrane. This domain is usually found in two copies that share little sequence similarity to each other.
Protein of unknown function DUF7374 (DUF7374)
Type: Family

This entry represents a small family of uncharacterised phage proteins. Structure prediction suggests that this protein dimerises.
Protein of unknown function DUF7375 (DUF7375)
Type: Family

This family represents a small family of uncharacterised proteins from Pseudomonas phage. These proteins range in length from 114 and 130 amino acids. Structure prediction suggests the proteins adopt an open set of α-helical segments as a monomer. However, homodimer prediction shows a confident interaction (iPTM 0.79). The dimer shows distinct charge distribution with a linear positively charged surface.
Protein of unknown function DUF7376 (DUF7376)
Type: Family

This entry represents a family of uncharacterised phage proteins. Structure prediction suggests these protein may form a homodimer. The dimer contains a large circular channel that is positively charged suggesting a possible DNA-binding function.
Domain of unknown function DUF7377 (DUF7377)
Type: Domain

This domain is found in uncharacterised plant proteins. It is predicted to adopt an α/β structure with a central four-stranded antiparallel β-sheet and α-helices packed on it. It has weak sequence and structural similarity to NIL domains. It is usually found N-terminal to protein kinase domains.
Domain of unknown function DUF7378 (DUF7378)
Type: Domain

This domain is found in uncharacterised plant proteins. It is predicted to contain transmembrane helices that assemble in a four helical bundle.
Domain of unknown function DUF7379 (DUF7379)
Type: Domain

This entry represents a domain of unknown function found towards the N-terminal of CHAT domain-containing protein, such as SwissProt:A0A100JVW6, from Streptomyces scabiei. This domain may adopt a A/B hydrolase fold and is often found in association with TCAD7 (Pfam:PF19973) and CHAT (Pfam:PF12770) domains.
Domain of unknown function DUF7380 (DUF7380)
Type: Domain

This domain is found N-terminal in uncharacterised bacterial proteins. It is predicted to adopt a globular structure composed mainly of α-helices.
Domain of unknown function DUF7381 (DUF7381)
Type: Domain

This domain is found N-terminal in uncharacterised nematode proteins. It is predicted to adopt a globular α/β structure.
Domain of unknown function DUF7382 (DUF7382)
Type: Domain

This is a Ig-like domain found in a group of uncharacterised sequences, mainly from archaea.
Protein of unknown function DUF7383 (DUF7383)
Type: Family

This entry represents a group of uncharacterised archaeal sequences containing a galactose binding-like domain.
Protein of unknown function DUF7384 (DUF7384)
Type: Family

This is a group of uncharacterised sequences from archaea which are related to VapC (virulence-associated protein C) family of proteins. Members of this entry may adopt a PIN-like fold.
Protein of unknown function DUF7385 (DUF7385)
Type: Family

This entry represents a small group of archaeal sequences whose function is unknown.
Protein of unknown function DUF7386 (DUF7386)
Type: Family

This is a family of archaeal sequences of unknown function.
Protein of unknown function DUF7387 (DUF7387)
Type: Family

This entry includes uncharacterised archaeal sequences.
Protein of unknown function DUF7388 (DUF7388)
Type: Family

This entry represents uncharacterised archaeal sequences.
Domain of unknown function DUF7389 (DUF7389)
Type: Domain

This is a domain of unknown function found in a group of archaeal sequences.
Domain of unknown function DUF7390 (DUF7390)
Type: Domain

This entry represents a family of uncharacterised phage protein. These proteins adopt a compact globular domain. The predicted structure of the domain shows a positively charged surface suggesting a possible nucleic acid binding function.
Protein of unknown function DUF7391 (DUF7391)
Type: Family

This entry represents a small family of uncharacterised phage proteins. Many of them are annotated as phage tail assembly chaperones, but there does not appear to be any evidence to support this annotation.
Domain of unknown function DUF7392 (DUF7392)
Type: Domain

This domain is found in uncharacterised proteins from plants. It has sequence and structural similarity to domains members of dimeric α/β barrel superfamily.
Domain of unknown function DUF7393 (DUF7393)
Type: Domain

This small uncharacterised phage protein has a 5 stranded β-barrel fold.
Protein of unknown function DUF7394 (DUF7394)
Type: Family

This entry represents a protein of unknown function, found primarily in phage proteins of about 60 to 75 amino acids in length. It contains a single predicted transmembrane helix in many members. Most sequences also contain a region of predicted intrinsic disorder at the C-terminal rich in basic and acidic residues. Further experimental study is required to determine the function of these proteins. Some proteins are annotated as holins but the source of this annotation is unknown.
Domain of unknown function DUF7395 (DUF7395)
Type: Domain

This entry represents a small family of uncharacterised phage proteins, that includes the L1 protein from Lactococcus phage c2

. Structure prediction indicates this small protein adopts a compact domain composed of a three stranded sheet with a single α-helix.
Protein of unknown function DUF7396 (DUF7396)
Type: Family

This entry represents an uncharacterised protein found in several bacteriophages that infect bacteria such as Escherichia coli, Enterobacter, Klebsiella and Shigella. The protein is short, around 44-51 amino acids in length. It is predicted to contain a single transmembrane helix. The function of this protein is currently unknown. One representative of this family is the

protein from bacteriophage T4.
Protein of unknown function DUF7397 (DUF7397)
Type: Family

This entry represents a small family of uncharacterised phage proteins. These proteins are around 50-60 residues in length.
Protein of unknown function DUF7398 (DUF7398)
Type: Family

This entry describes an uncharacterised protein found in several bacteriophages that infect Bacillus species. The protein ranges in length from 158 to 189 amino acids. It is found in the virions of phages from the Bastillevirinae subfamily of the Herelleviridae family. Structure prediction suggests the proteins are composed of a bundle of five α-helices.
Protein of unknown function DUF7399 (DUF7399)
Type: Family

This entry represents a family of phage proteins. The proteins appear to contain two domains. The N-terminal domain contains a small β-sheet wrapped around an α-helix. The second domain is composed of a pair of α-helices. The proteins are found in several viruses within the proposed new Crassvirales order of bacteriophages.
Domain of unknown function DUF7400 (DUF7400)
Type: Domain

This entry represents a domain of unknown function found towards the N-terminal of some PRiA4b ORF-3-like proteins from bacteria, such as

. This domain may adopt a TPR-like fold and is generally associated to PriA4_ORF3 (

) domain.
Domain of unknown function DUF7401 (DUF7401)
Type: Domain

This entry represents a domain of unknown function found towards the centre of some PRiA4b ORF-3-like proteins from bacteria, such as

. This domain is generally associated to PriA4_ORF3 (

) domain.
Domain of unknown function DUF7402 (DUF7402)
Type: Domain

This entry represents the domain of unknown function found in bacterial and fungal sequences, including some F5/8 type C domain-containing proteins such as Swissprot:A0A4V0YDU8. This domain may adopt a galactose-binding domain-like fold. This domain is found in several copies, predominantly between two and six times, and it is found in association with PIG-L (Pfam:PF02585) domain.
Domain of unknown function DUF7403 (DUF7403)
Type: Domain

This entry represents a domain of unknown function found in some PRiA4b ORF-3-like proteins from bacteria, such as

. This domain may adopt an all-helical fold and is generally found alongside the PriA4_ORF3 (

) domain.
Protein of unknown function DUF7405 (DUF7405)
Type: Family

This entry represents a family or archaeal proteins whose function is unknown. They may adopt a dimeric α/β-barrel fold.
Domain of unknown function DUF7406 (DUF7406)
Type: Domain

This is a small domain found in a group of uncharacterised archaeal sequences. This small domain may have an all-beta fold.
Domain of unknown function DUF7407 (DUF7407)
Type: Domain

This is a domain of unknown function found in a group of uncharacterised sequences from archaea. This domain may have a β-sandwich fold.
Domain of unknown function DUF7408 (DUF7408)
Type: Domain

This is a domain of unknown function found in a group of uncharacterised sequences from archaea. It may adopt an amidotransferase-like fold.
Domain of unknown function DUF7409 (DUF7409)
Type: Domain

This is a domain of unknown function found in uncharacterised archaeal sequences.
Domain of unknown function DUF7410 (DUF7410)
Type: Domain

This is a C2H2 zinc finger found in a group of uncharacterised proteins from archaea.
Protein of unknown function DUF7411 (DUF7411)
Type: Family

This is a family of unknown function mainly found in archaea but also in some bacterial species. The structure of a member of this family from Methanocaldococcus jannaschii adopts a Rossmann-like α/β/α fold (

) with significant similarity to HUP domains, particularly to Queuosine biosynthesis protein QueC family

.
Domain of unknown function DUF7412 (DUF7412)
Type: Domain

This entry represents an uncharacterised protein family found in a range of bacteriophage including Phage T2. These proteins include a β-barrel domain. Many members of the family are annotated as IP4 internal head protein, although the source of evidence for this annotation was not found.
Domain of unknown function DUF7413 (DUF7413)
Type: Domain

This entry represents a small family of uncharacterised phage proteins. Structure prediction suggests these proteins are composed of a three stranded β-sheet packed against a pair of α-helices.
Domain of unknown function DUF7414 (DUF7414)
Type: Domain

This entry represents an uncharacterised family of proteins. Structure prediction suggests these proteins form a four stranded β sheet with a helix packed on one side. Structure prediction also suggests a confident dimer. The structure shows some weak similarity to large ribosomal subunit protein eL38.
Domain of unknown function DUF7415 (DUF7415)
Type: Domain

This entry represents a family of uncharacterised phage domains. This domain is found in one to two copies per proteins. It seems likely that the proteins with a single copy of the domain form homodimers.
Protein of unknown function DUF7416 (DUF7416)
Type: Family

This entry represents a small uncharacterised enterobacterial phage protein family. Structure prediction suggests these proteins might adopt a pair of α-helices.
Domain of unknown function DUF7417 (DUF7417)
Type: Domain

This entry represents an uncharacterised protein domain found in various phage and bacterial proteins. The domain is approximately 60-80 amino acids in length. The domain is composed of four α-helices that form a small bundle. The surface of the domain is negatively charged.
Domain of unknown function DUF7418 (DUF7418)
Type: Domain

This entry represents a small uncharacterised family of phage proteins. It adopts a novel triangular beta prism structure.
Protein of unknown function DUF7419 (DUF7419)
Type: Family

This entry represents a family of uncharacterised mycobacteria phage proteins that adopt a zinc binding domain composed of 5 potential ligand residues. The zinc binding motif is composed of a CXXC and a CXXHH motif.
Protein of unknown function DUF7420 (DUF7420)
Type: Family

This entry represents an uncharacterised family of phage integral membrane proteins. The proteins are found in phage of S. aureus and B. subtilis. These proteins contain three potential transmembrane helices. There is a conserved GXXPL motif that is highly conserved between helices 1 and 2.
Protein of unknown function DUF7421 (DUF7421)
Type: Family

This entry represents a small family of uncharacterised enterobacterial phage proteins.
Protein of unknown function DUF7422 (DUF7422)
Type: Family

This entry represents a small family of phage proteins. The family includes members from Phage T2 and T6. These proteins contain a small three stranded beta domain. Some members have an additional small C-terminal domain composed of a beta-alpha-alpha-beta hairpin domain.
Domain of unknown function DUF7423 (DUF7423)
Type: Domain

This entry represents a family of uncharacterised mycobacterial phage proteins. The proteins have a domain that contains a four helical bundle.
Domain of unknown function DUF7424 (DUF7424)
Type: Domain

This entry represents a family of uncharacterised lipoproteins. The family includes a range of both bacteria and phage proteins.
Domain of unknown function DUF7425 (DUF7425)
Type: Domain

This entry represents a domain of unknown function found in bacteriophage proteins. The domain is around 90-95 amino acids in length. It is found in uncharacterised proteins from phages that infect Enterobacteria such as Salmonella and Shigella species as well as Dickeya. The specific function of this domain remains unknown. Structure prediction suggests that these proteins may form a homotetramer (iPTM=0.88). The domain contains a three twisted stranded β-sheet.
Domain of unknown function DUF7426 (DUF7426)
Type: Domain

This entry represents an uncharacterised domain found in phage proteins.
Protein of unknown function DUF7427 (DUF7427)
Type: Family

This entry represents a family of uncharacterised phage proteins. Family members are largely found in mycobacterial phage.
Domain of unknown function DUF7428 (DUF7428)
Type: Domain

This entry represents a small family of uncharacterised phage proteins. The structure of this family is predicted to be composed of a four stranded β-sheet and a single α-helix.
Protein of unknown function DUF7429 (DUF7429)
Type: Family

This entry represents a family of small uncharacterised proteins found in mycobacterial phage.
Protein of unknown function DUF7430 (DUF7430)
Type: Family

This entry represents a family of uncharacterised phage proteins.
Domain of unknown function DUF7431 (DUF7431)
Type: Domain

This entry represents the domain of unknown function found towards the C-terminal of some MACPF domain-containing proteins from fungi, such as SwissProt:A0A2P4PCT2. It is found associated with MACPF_1 (Pfam:PF22693) domain.
Protein of unknown function DUF7432 (DUF7432)
Type: Family

This entry represents a family of uncharacterised phage proteins that are composed of two small domains connected by an α-helix. Structure prediction suggests that these proteins may homodimerise or tetramerise. These proteins are primarily found in Gordonia phage.
Protein of unknown function DUF7433 (DUF7433)
Type: Family

This entry represents a small region that is found in a variety of uncharacterised mycobacterial phage proteins. Structure prediction suggests it adopts an α-helix and β-hairpin structure that likely homodimerises.
Protein of unknown function DUF7434 (DUF7434)
Type: Family

This entry represents a small family of uncharacterised mycobacterial phage proteins. Structure prediction suggests that this protein forms a single α-helix. It is quite hydrophobic with a negatively charged C-terminal. Some proteins are annotated as RDF proteins but there does not appear to be any evidence to support their function as recombination directionality factors.
Domain of unknown function DUF7435 (DUF7435)
Type: Domain

This entry represents a family of uncharacterised proteins found in Mycobacterium phages. The family members are typically around 67 amino acids in length. Structure prediction suggests these proteins form a small compact domain composed of four β-strands followed by an α-helix. The domain possibly shows weak structural similarity to integrase arm-type binding domain.
Domain of unknown function DUF7436 (DUF7436)
Type: Domain

This domain is found at the C-terminal end of a group of archaeal sequences that contain

at the N-terminal. It is predicted to adopt an α-β configuration.
Domain of unknown function DUF7437 (DUF7437)
Type: Domain

This domain is found at the C-terminal end of a group of archaeal sequences that contain

at the N-terminal. It is predicted to adopt an all-α configuration.
Protein of unknown function DUF7438 (DUF7438)
Type: Family

This entry represents a family of uncharacterised proteins found in bacteriophages, including members from Phage T2, T4 and T6. Members of this family are typically short proteins of around 60-67 amino acids in length. The structure of these proteins is predicted to be composed of two α-helices that pack together. Structure prediction suggests these proteins may homodimerise (iPTM=0.83). Its function is currently unknown.
Protein of unknown function DUF7439 (DUF7439)
Type: Family

This entry represents a family of small putative transmembrane proteins found primarily in Streptomyces phages and some bacteria. The family is characterised by a conserved transmembrane region typically located between residues 20-45 of the alignment. Many members of this family are around 70 amino acids in length. The function of this protein family is currently unknown.
Protein of unknown function DUF7440 (DUF7440)
Type: Family

This entry represents a protein family of unknown function found in various bacterial phage proteins. The family typically consists of proteins around 140-160 amino acids in length. It is found in phages that infect bacteria such as Salmonella, Escherichia, Shigella, and Dickeya. The function of this family remains unclear. Some members of this family are annotated as uncharacterised or hypothetical proteins. AlphaFold predictions suggest the proteins in this family contain two distinct domains, with a central domain composed of a three stranded β-sheet and a C-terminal small 3-helix bundle domain.
Domain of unknown function DUF7441 (DUF7441)
Type: Domain

This entry represents a conserved domain found predominantly in bacteriophage proteins. The domain is characterised by a highly conserved YDRH motif, which likely plays an important role in the domain's function or structure. This group includes proteins from various phages that infect cyanobacteria, particularly Synechococcus and Prochlorococcus species. The proteins contain a central small domain composed of a three stranded β-sheet with an α-helix inserted between the second and third strands.
Phage membrane protein-like (Phage_memb_DUF7442)
Type: Family

This entry represents a family of putative membrane proteins found in various bacteriophages. The proteins in this family typically contain two transmembrane helices. The function of these proteins is currently unknown. They are predominantly found in phages infecting Salmonella, Escherichia, and other enterobacteria. The proteins in this family are generally short, with most members being around 80-81 amino acids in length
Domain of unknown function DUF7443 (DUF7443)
Type: Domain

This entry represents an uncharacterised protein family found in bacteriophages. The function of this family is currently unknown. Members of this family are typically around 90-100 amino acids in length. The family includes proteins from various phage species infecting bacteria such as Salmonella, Klebsiella, and Proteus. Some members of this family contain disordered regions, particularly in their C-terminal portions. Conserved basic and acidic residues are present in many family members, which may be functionally important. This entry represents the globular N-terminal domain of these proteins.
Protein of unknown function DUF7444 (DUF7444)
Type: Family

This entry represents a conserved family found in various bacteriophages, particularly those infecting Escherichia, Klebsiella, and other Enterobacteriaceae. The function of this domain is currently unknown. This family is commonly found in phages belonging to the Drexlerviridae family, including genera such as Webervirus, Tempevirinae, and Tunavirinae. This entry shows some structurally similar features to

.
Protein of unknown function DUF7445 (DUF7445)
Type: Family

This entry represents an uncharacterised protein family found in mycobacteriophages. The function of this protein is currently unknown. The family is approximately 147 amino acids long. These proteins contain two small domains. The most N-terminal one contains a CXXC and HXXC motif that likely bind to zinc.