SII-SWORD/CoKE huggingface dataset:
Protein of unknown function DUF7543 (DUF7543)
Type: Family

This entry represents a family of small uncharacterised proteins found mainly in Halobacteria. They are predicted to adopt a globular α/β structure consisting of five-stranded β-sheet and an α-helix packed on it.
Protein of unknown function DUF7544 (DUF7544)
Type: Family

This entry represents a family of uncharacterised prokaryotic proteins. They are likely associated with the membrane and consists of several transmembrane helices.
Protein of unknown function DUF7545 (DUF7545)
Type: Family

This entry represents a family of uncharacterised proteins found mainly in Halobacteria. These proteins are likely to form a dimer structure as predicted by AlphaFold with significant ipTM score.
Protein of unknown function DUF7546 (DUF7546)
Type: Family

This entry represents a group of uncharacterised proteins found mainly in Halobacteria. These proteins are likely associated with the membrane.
Protein of unknown function DUF7547 (DUF7547)
Type: Family

This entry represents a group of uncharacterised archaeal proteins. These proteins probably do not adopt a globular structure.
Protein of unknown function DUF7548 (DUF7548)
Type: Family

This entry represents a group of uncharacterised archaeal proteins. They are predicted to fold into a four helical bundle.
Protein of unknown function DUF7549 (DUF7549)
Type: Family

This entry represents a group of uncharacterised archaeal proteins. They are predicted to adopt α/β structure consisting of five-stranded antiparallel β-sheet and five α-helices protruding from it.
Protein of unknown function DUF7550 (DUF7550)
Type: Family

This entry represents a group of small uncharacterised archaeal proteins. They are predicted to fold into a single α-helix.
Domain of unknown function DUF7551 (DUF7551)
Type: Domain

This entry represents a domain found in a group of uncharacterised proteins from Halobacteria. This domain contains a pair of highly conserved cysteine residues.
Domain of unknown function DUF7552 (DUF7552)
Type: Domain

This domain is found in a group of uncharacterised proteins mainly from Halobacteria. It is frequently found in combination with

.
Protein of unknown function DUF7553 (DUF7553)
Type: Family

This is a small family of uncharacterised archaeal proteins. They are predicted to fold into a helical hairpin.
Protein of unknown function DUF7554 (DUF7554)
Type: Family

This entry represents a small family of uncharacterised proteins found in archaea. These proteins are likely associated with the membrane. They are predicted to fold into a single helix.
Protein of unknown function DUF7555 (DUF7555)
Type: Family

This entry represents a small family of uncharacterised proteins found in Halobacteria. These proteins are likely associated with the membrane. They are predicted to fold into a three helical bundle.
Protein of unknown function DUF7556 (DUF7556)
Type: Family

This entry represents a small family of uncharacterised proteins found in archaea. These proteins are predicted to be largely disordered. They contain a semi-conserved VIADxx[DE]xAW sequence motif.
Protein of unknown function DUF7557 (DUF7557)
Type: Family

This entry represents a small family of uncharacterised proteins found in archaea. They may be part of toxin/antitoxin system.
Protein of unknown function DUF7558 (DUF7558)
Type: Family

This entry represents a small family of uncharacterised proteins found in archaea. They contain four pairs of conserved cysteines as well as several conserved histidines. It is likely that these residues are involved in metal coordination.
Protein of unknown function DUF7559 (DUF7559)
Type: Family

This entry represents a small family of uncharacterised proteins found in archaea. They contain two pairs of conserved cysteines that are likely involved in metal coordination. It is predicted to structurally resemble Zinc-beta ribbon domains.
Protein of unknown function DUF7560 (DUF7560)
Type: Family

This entry represents a small family of uncharacterised proteins found in archaea. They contain two pairs of conserved cysteines that are likely involved in metal coordination. It is predicted they may structurally resemble Zinc-beta ribbon domains.
Protein of unknown function DUF7561 (DUF7561)
Type: Family

This entry represents a small family of uncharacterised proteins found in archaea. They contain two pairs of conserved cysteines that are likely involved in metal coordination. These proteins are predicted to structurally resemble treble-clef zinc fingers.
Protein of unknown function DUF7562 (DUF7562)
Type: Family

This entry represents a small family of uncharacterised proteins found in archaea. They contain two pairs of conserved cysteines that are likely involved in metal coordination. These proteins are predicted to structurally resemble treble-clef zinc fingers.
Protein of unknown function DUF7563 (DUF7563)
Type: Family

This entry represents a small family of uncharacterised proteins found in archaea. They contain two pairs of conserved cysteines that are likely involved in metal coordination. These proteins are predicted to structurally resemble Zinc beta-ribbon domains.
Protein of unknown function DUF7564 (DUF7564)
Type: Family

This entry represents a small family of uncharacterised proteins found in Haloferacales. They contain two pairs of conserved cysteines that are likely involved in metal coordination. These proteins are predicted to structurally resemble treble-clef zinc fingers.
Protein of unknown function DUF7565 (DUF7565)
Type: Family

This entry represents a small family of uncharacterised proteins found in archaea and eukaryotes. These proteins contain two pairs of conserved cysteines and two pairs of conserved histidines that are probably involved in zinc coordination. These proteins likely resemble two classical C2H2 zinc fingers that pack on each other and form a compact globular structure.
Protein of unknown function DUF7566 (DUF7566)
Type: Family

This entry represents a family of uncharacterised proteins from phage. Structure predictions suggest the protein is composed of a larger N-terminal domain with an 8 stranded β sheet. Followed by a C-terminal helical domain.
Protein of unknown function DUF7567 (DUF7567)
Type: Family

This entry represents a small family of uncharacterised proteins found in Halobacteria. They contain two pairs of conserved cysteines that are likely involved in metal coordination. These proteins are predicted to structurally resemble Zinc beta-ribbon domains.
Protein of unknown function DUF7568 (DUF7568)
Type: Family

This entry represents a small family of uncharacterised proteins found in Halobacteria. They contain two pairs of conserved cysteines that are likely involved in metal coordination. These proteins are predicted to contain two subdomains one of which is consisting of a five-stranded antiparallel β-sheet and a helix packed on it followed by a zinc β-ribbon domain.
Protein of unknown function DUF7569 (DUF7569)
Type: Family

This entry represents a small family of uncharacterised proteins found mainly in Halobacteria. They contain two pairs of conserved cysteines that are likely involved in metal coordination. These proteins are predicted to structurally resemble treble-clef zinc fingers.
Protein of unknown function DUF7570 (DUF7570)
Type: Family

This entry represents a family of uncharacterised phage proteins. The proteins are composed of an N-terminal three helical bundle followed by an α-helical region at the C-terminal.
Protein of unknown function DUF7571 (DUF7571)
Type: Family

This entry represents a small family of uncharacterised proteins found mainly in Halobacteria. They contain four pairs of conserved cysteines that are likely involved in metal coordination.
Domain of unknown function DUF7572 (DUF7572)
Type: Domain

This entry represents a family of uncharacterised mycophage proteins. These proteins form a compact domain composed of 5 or 6 antiparallel β-strands that curve around a C-terminal α-helix.
Domain of unknown function DUF7573 (DUF7573)
Type: Domain

This entry represents a small family of uncharacterised proteins found mainly in Halobacteria. They contain two pairs of conserved cysteines that are likely involved in metal coordination.
Domain of unknown function DUF7574 (DUF7574)
Type: Domain

This entry represents a small family of uncharacterised phage proteins.
Domain of unknown function DUF7575 (DUF7575)
Type: Domain

This domain is found in uncharacterised eu- and prokaryotic proteins. It contains four invariant cysteines and it is predicted to adopt a Zn-ribbon fold.
Protein of unknown function DUF7576 (DUF7576)
Type: Family

This entry represents a small family of uncharacterised archaeal proteins. They contain two pairs of conserved cysteine residues and are predicted to adopt a fold typical for Treble-clef zinc fingers.
Domain of unknown function DUF7577 (DUF7577)
Type: Domain

This entry represents a domain found in uncharacterised proteins from prokaryotes. It contains two pairs of conserved cysteines that are likely involved in metal coordination. This domain is predicted to structurally resemble Zinc beta-ribbon domains.
Domain of unknown function DUF7578 (DUF7578)
Type: Domain

This domain is found in uncharacterised eukaryotic proteins. It is sometimes found in tandem. This domain is predicted to adopt a globular structure consisting of α-helices with some similarity to SAM domains.
Domain of unknown function DUF7579 (DUF7579)
Type: Domain

This domain is centrally located in a group of uncharacterised plant proteins. It is often found associated to

.
Domain of unknown function DUF7580 (DUF7580)
Type: Domain

This domain is found in a group of uncharacterised eukaryotic proteins. It has a detectable sequence similarity to protein kinase domains and it is predicted to adopt similar structure.
CT398-like coiled coil hairpin domain (CT398_CC_hairpin)
Type: Domain

This entry, previously known as DUF7581, represents a coiled coil hairpin domain found N-terminal in CT398 from C. trachomatis, MSMEG_4306 M. smegmatis and related bacterial sequences predominantly from actinobacteria. Both CT398 and MSMEG_4306 proteins have been structurally characterised . CT398 protein is involved in several aspects of chlamydial biology and pathogenesis, and is capable of interacting with multiple binding partners. The coiled coil hairpin domain of CT398 engages in interaction with RpoN as well as both T3SS ATPase-regulators FliH and CdsL .
Domain of unknown function DUF7582 (DUF7582)
Type: Domain

This domain is found in uncharacterised sequences from fungi. It may adopt a nucleotidyl transferase-like fold.
Domain of unknown function DUF7583 (DUF7583)
Type: Domain

This is an Ig-like domain found in a group of uncharacterised sequences from nematodes. The function of this domain is unknown.
Domain of unknown function DUF7584 (DUF7584)
Type: Domain

This is an Ig-like domain found in the middle region of a group of uncharacterised sequences from nematodes.
Domain of unknown function DUF7585 (DUF7585)
Type: Domain

This is a presumed domain found at the N-terminal of uncharacterised sequences from Strongyloides species. This domain may consist of a β-sandwich fold.
Domain of unknown function DUF7586 (DUF7586)
Type: Domain

This domain is found in bacterial uncharacterised proteins that probably belong to the penicillin-binding protein-type class of thioesterases. This domain is predicted to fold into a meander β-barrel consisting of eight antiparallel β-strands. It contains a semi-conserved GxWxW sequence motif near the N terminus.
Domain of unknown function DUF7587 (DUF7587)
Type: Domain

This domain is found in a group of uncharacterised proteins predominantly from fungi. It has a detectable similarity to ADP ribosyltransferase domains and it is predicted to adopt a similar structure.
Domain of unknown function DUF7588 (DUF7588)
Type: Domain

This domain is found in uncharacterised proteins mainly from plants. It is predicted to adopt an α-helical structure consisting of four helices. This domain contains several conserved aromatic hydrophobic residues that may have a functional role.
Domain of unknown function DUF7589 (DUF7589)
Type: Domain

This domain is found in uncharacterised proteins mainly from plants. It is predicted to fold into a six-stranded β-barrel. Inserted in this barrel is an α-helix that packs on the barrel side and it is enriched with positively charged residues which may have a functional importance.
Domain of unknown function DUF7590 (DUF7590)
Type: Domain

This domain is found in uncharacterised proteins mainly from Fungi. It has a detectable similarity to known galactose-binding domains, in particular to the C-terminal domain of Bacillus sp. alkaline serine protease, and is predicted to adopt similar structure.
Domain of unknown function DUF7591 (DUF7591)
Type: Domain

This entry represents a domain of unknown function found in proteins from C. elegans and related sequences from Caenorhabditis species. It may adopt a CUB-like domain fold.
Domain of unknown function DUF7592 (DUF7592)
Type: Domain

This is a domain found in uncharacterised sequences from Caenorhabditis spp. In SwissProt:O45754, it represents the second domain. It may adopt a CUB-like fold.
Domain of unknown function DUF7593 (DUF7593)
Type: Domain

This domain of unknown function is found in uncharacterised fungal sequences.
Domain of unknown function DUF7595 (DUF7595)
Type: Domain

This entry represents a domain of unknown function found in uncharacterised plant sequences. This domain may have a β-propeller structure.
Domain of unknown function DUF7596 (DUF7596)
Type: Domain

This is a GNAT-like domain found at the N-terminal of uncharacterised sequences from nematodes.
Domain of unknown function DUF7597 (DUF7597)
Type: Domain

This domain is found in uncharacterised plant proteins.
Domain of unknown function DUF7598 (DUF7598)
Type: Domain

This domain is found in a group of uncharacterised fungal proteins. It is predicted to adopt an all-alpha configuration.
Domain of unknown function DUF7599 (DUF7599)
Type: Domain

This is a domain of unknown function found in a group of uncharacterised proteins from plants and some fungal species. This domain is usually found associated with

and

.
Domain of unknown function DUF7600 (DUF7600)
Type: Domain

This domain of unknown function is found once or twice in a group of fungal uncharacterised proteins. It is predicted to adopt a mainly beta configuration.
Domain of unknown function DUF7602 (DUF7602)
Type: Domain

This domain is found in uncharacterised sequences from Plasmodium falciparum and related sequences from Apicomplexa. The function is unknown.
Domain of unknown function DUF7603 (DUF7603)
Type: Domain

This entry includes uncharacterised fungal sequences. It represents a long α-helix found near the C-terminal.
Domain of unknown function DUF7605 (DUF7605)
Type: Domain

This is an helical domain found at the C-terminal of fungal sequences, whose function is unknown.
ACP-like domain (ACP_dom)
Type: Domain

This domain, previously known as DUF7606, is found in Neisseria Adhesin Complex Protein (ACP) and in a group of uncharacterised sequences from proteobacteria. It folds into an eight-stranded β-barrel, stabilised by a disulphide bond between the first and last β-strands . Nm-ACP is structurally similar to the MliC/PliC protein family of lysozyme inhibitors. Despite it does not share any conserved MliC/PliC sequence motifs associated with lysozyme recognition, ACP is capable of inhibiting lysozyme.
Domain of unknown function DUF7607 (DUF7607)
Type: Domain

This domain is found in uncharacterised proteins mainly from fungi. It is predicted to fold into an α-helical structure composed of three helices.
Domain of unknown function DUF7608 (DUF7608)
Type: Domain

This domain is found in uncharacterised fungal proteins. It is predicted to adopt an α-helical structure consisting of four helices.
Domain of unknown function DUF7609 (DUF7609)
Type: Domain

This entry represents a domain found in a family of uncharacterised phage proteins. Structure prediction suggests that this protein may homodimerise (A0A377YTN9 ipTM=0.68).
Domain of unknown function DUF7610 (DUF7610)
Type: Domain

This domain is found in uncharacterised proteins mainly from plants. It is predicted to adopt three-helical bundle.
Domain of unknown function DUF7611 (DUF7611)
Type: Domain

This domain is found in uncharacterised proteins mainly from fungi. It is predicted to fold into a β-barrel with a PH-like topology.
Domain of unknown function DUF7612 (DUF7612)
Type: Domain

This domain is found in uncharacterised proteins mainly from fungi. It is predicted to fold into a β-barrel with a PH-like topology.
Domain of unknown function DUF7613 (DUF7613)
Type: Domain

This domain is found in uncharacterised proteins mainly from fungi. It is predicted to fold into a β-barrel with a PH-like topology.
Domain of unknown function DUF7614 (DUF7614)
Type: Domain

This domain is found in uncharacterised proteins mainly from fungi. It is predicted to fold into a β-barrel with a PH-like topology.
Domain of unknown function DUF7615 (DUF7615)
Type: Domain

This domain is found in uncharacterised proteins mainly from plants. This domain is predicted to fold into an α-helical hairpin.
Protein of unknown function DUF7616 (DUF7616)
Type: Family

This entry represents a small family of uncharacterised proteins from enterobacterial phage. The proteins are around 56 residues in length.
Protein of unknown function DUF7618 (DUF7618)
Type: Family

This entry represents a small family of uncharacterised phage proteins.
Protein of unknown function DUF7620 (DUF7620)
Type: Family

This entry represents a family of small uncharacterised phage proteins that are predicted to form a coiled-coil. However, structure predictions do not predict homodimeric or homotrimeric complexes.
Protein of unknown function DUF7621 (DUF7621)
Type: Family

This entry represents a small family of uncharacterised phage proteins.
Domain of unknown function DUF7622 (DUF7622)
Type: Domain

This domain is found several times in a group of uncharacterised proteins from nematodes. It is predicted to adopt a mainly beta configuration.
Domain of unknown function DUF7623 (DUF7623)
Type: Domain

Several copies of this domain of unknown function are found in a group of uncharacterised proteins from lower eukaryotes. It is often found associated to

and

.
Domain of unknown function DUF7624 (DUF7624)
Type: Domain

This domain is found in uncharacterised proteins mainly from fungi. It is predicted to adopt a globular structure composed of α-helices. This domain has a number of conserved positively changed residues that in the predicted structure define a large positively charged patch on the surface.
Domain of unknown function DUF7625 (DUF7625)
Type: Domain

This domain is found in uncharacterised proteins mainly from plants. This domain is predicted to fold into a globular structure with a winged helix HTH topology.
Domain of unknown function DUF7626 (DUF7626)
Type: Domain

This is a HTH-like domain found in uncharacterised sequences from fungi.
Domain of unknown function DUF7627 (DUF7627)
Type: Domain

This entry represents a domain found in the uncharacterised protein B0303.14 (

) from C.elegans and related sequences from nematodes.
Domain of unknown function DUF7628 (DUF7628)
Type: Domain

This is a domain of unknown function found in uncharacterised sequences from Plasmodium and related sequences from Plasmodiidae.
Domain of unknown function DUF7629 (DUF7629)
Type: Domain

This is an Ig-like domain found at the N-terminal of proteins from Plasmodium falciparum and related sequences from Plasmodiidae. The function of these protein is unknown.
Cysteine repeat modular protein A-like, DUF7630 (CRMPA-like_DUF7630)
Type: Domain

This presumed domain is found in Cysteine repeat modular protein A from Toxoplasma gondii (CRMPA), uncharacterised sequences from Plasmodium falciparum and similar sequences from lower eukaryotes. CRMPA is required for triggering rhoptry secretion and plays a role in host cell invasion . This domain may adopt a TNF receptor-like fold.
Cysteine repeat modular protein A/B-like, DUF7631 (CRMPA/B-like_DUF7631)
Type: Domain

This presumed domain is found in Cysteine repeat modular protein A/B from Toxoplasma gondii (CRMPA/B), uncharacterised sequences from Plasmodium falciparum and similar sequences from Apicomplexa. CRMPA/B are required for triggering rhoptry secretion and play a role in host cell invasion . This domain may adopt a TNF receptor-like fold.
Domain of unknown function DUF7632 (DUF7632)
Type: Domain

This is a presumed helical domain found at the C-terminal of a group of uncharacterised sequences from Plasmodium falciparum and related sequences from Apicomplexa.
Domain of unknown function DUF7633 (DUF7633)
Type: Domain

This presumed domain is found at the C-terminal of uncharacterised sequences from diatoms, which is usually associated with a β-solenoid at the N-terminal. This domain may adopt a β-sandwich fold.
Domain of unknown function DUF7634 (DUF7634)
Type: Domain

This is a presumed β-sandwich domain found near the central region of uncharacterised sequences from Plasmodium falciparum (

) and similar sequences from Apicomplexa.
Domain of unknown function DUF7635 (DUF7635)
Type: Domain

This is a presumed domain found in uncharacterised sequences from Plasmodium falciparum (

) and similar sequences from Apicomplexa. It may adopt a β-propeller-like fold, which, from structure predictions, it seems incomplete.
Domain of unknown function DUF7636 (DUF7636)
Type: Domain

This domain is found in uncharacterised proteins mainly from nematodes. It is predicted to adopt a globular structure consisting of a three-stranded antiparallel β-sheet and three α-helices packed on one side of it.
Domain of unknown function DUF7637 (DUF7637)
Type: Domain

This domain is found in uncharacterised proteins mainly from nematodes. It is predicted to adopt a globular structure consisting of a four-stranded antiparallel β-sheet and two α-helices packed on one side of it.
Domain of unknown function DUF7638 (DUF7638)
Type: Domain

This domain is found in uncharacterised bacterial proteins. It is predicted to adopt an α/β structure consisting of curved β-sheet and α-helices packed on the concave side of it.
Domain of unknown function DUF7639 (DUF7639)
Type: Domain

This domain is found in uncharacterised bacterial proteins. It is predicted to adopt a globular structure composed of a three helical bundle.
Domain of unknown function DUF7640 (DUF7640)
Type: Domain

This is a presumed domain found in a group of uncharacterised sequences from diatoms, in some members this domain is repeated twice or three times. This domain may adopt a β-solenoid fold.
Domain of unknown function DUF7641 (DUF7641)
Type: Domain

This entry includes uncharacterised sequences from Plasmodium sp. and similar sequences from Apicomplexa. This entry may represent transmembrane helices.
Domain of unknown function DUF7642 (DUF7642)
Type: Domain

This domain is found in uncharacterised sequences from plants.
Tal, N-terminal tail tube TT1 domain (Tal_TT1_dom)
Type: Domain

This domain, previously known as DUF7643, is found N-terminal in the tail-associated lysin (Tal, gp59) and related sequences from phages and bacteriophages. gp59 is comprising the tip of the phage tail. The domain represented by this entry is one of the two tail tube domains (TT1 and TT2) that form a quasi-sixfold adapter to the distal tail protein (Dit, gp58) hexamer . These two domains merge into a continuous eight-stranded β-sheet on one side.
Domain of unknown function DUF7644 (DUF7644)
Type: Domain

This entry represents a small family of uncharacterised staphylococcal phage proteins. Structure prediction suggests they form a compact domain composed of a three stranded β-sheet packed against an α-helix.
Domain of unknown function DUF7645 (DUF7645)
Type: Domain

This domain is found in uncharacterised proteins mainly from plants. It is predicted to fold into a three helical bundle.
Domain of unknown function DUF7646 (DUF7646)
Type: Domain

This domain is found in uncharacterised proteins mainly from plants. It has detectable similarity to winged helix HTH domains and it is predicted to adopt similar structure.