SII-SWORD/CoKE huggingface dataset:
Domain of unknown function DUF7647 (DUF7647)
Type: Domain

This domain is found in uncharacterised proteins mainly from plants. It is predicted to adopt a globular structure consisting of array of helices.
Domain of unknown function DUF7648 (DUF7648)
Type: Domain

This domain is found in uncharacterised proteins mainly from plants. It is predicted to adopt a globular structure consisting of array of helices.
Domain of unknown function DUF7649 (DUF7649)
Type: Domain

This domain is found in uncharacterised bacterial proteins. It is predicted to adopt a non-compact structure consisting of four highly hydrophobic α-helices that could potentially dimerise.
Domain of unknown function DUF7650 (DUF7650)
Type: Domain

This domain is found in uncharacterised proteins mainly from plants. It is predicted to adopt mainly helical structure.
EMF2-like, DUF7651 (EMF2-like_DUF7651)
Type: Domain

This domain of unknown function is found at the N-terminal end of Polycomb group protein EMBRYONIC FLOWER 2 (EMF2) from Arabidopsis thaliana and similar plant proteins. EMF2 is involved in flowering processes by repressing unknown target genes and preventing reproductive development . This domain is predicted to adopt a globular structure that resembles barrel-sandwich hybrid. The β-sandwich has a topology most similar to C2 domains found in diverse proteins such as CEP120, Dysferlin and Myoferlin.
Domain of unknown function DUF7652 (DUF7652)
Type: Domain

This is an Ig-like domain found towards the C-terminal of a group of uncharacterised sequences from Strongyloides spp. and similar sequences from nematodes.
Domain of unknown function DUF7653 (DUF7653)
Type: Domain

This domain is found in uncharacterised proteins mainly from plants.
Domain of unknown function DUF7654 (DUF7654)
Type: Domain

This domain is found in uncharacterised bacterial proteins. It is predicted to adopt a globular α/β structure.
SNTX, MACPF/CDC-like domain (SNTX_MACPF/CDC-like_dom)
Type: Domain

This MACPF/CDC-like domain is found N-terminal in a number of toxins including Stonustoxin (SNTX), Neoverrucotoxin (NeoVTX), Verrucotoxin (VTX), Sp-CTx and related proteins. This domain is a pore-forming domain and is involved in the formation of large ring-shaped pores in rat erythrocyte membranes . The formation of MACPF/CDC-like pores is probably central to the toxin's hemolytic activity, and cell lysis could explain physiological effects, including edema, increased vascular permeability, and muscle damage.
Domain of unknown function DUF7656 (DUF7656)
Type: Domain

This domain is found in a group of uncharacterised eukaryotic proteins. It shares detectable similarity to the Thioredoxin-like SNTX domain (Pfam:PF18078) and it is predicted to adopt similar structure.
Domain of unknown function DUF7657 (DUF7657)
Type: Domain

This domain is found in uncharacterised bacterial proteins. It contains a semi-conserved sequence motif TxYPGxR. It is likely that this domain is a transmembrane domain composed of α-helices.
Domain of unknown function DUF7658 (DUF7658)
Type: Domain

This is a presumed domain found towards the C-terminal of a group of uncharacterised sequences from nematodes, including the uncharacterised protein F54D1.6 from Caenorhabditis elegans. This domain is found immediately N-terminal to

.
Protein of unknown function DUF7659 (DUF7659)
Type: Family

This family of uncharacterised proteins is found in bacteria and phage. Proteins in this family are typically between 128 and 147 amino acids in length. The proteins contain two subdomains separated by an α-helical linker.
Domain of unknown function DUF7660 (DUF7660)
Type: Domain

This family represents a set of uncharacterised bacterial proteins. Structure prediction shows them to be composed of three α-helices.
Domain of unknown function DUF7661 (DUF7661)
Type: Domain

This entry represents a family of small uncharacterised bacterial proteins that adopts a compact domain composed of 5 β-strands and a single α-helix.
Domain of unknown function DUF7662 (DUF7662)
Type: Domain

This domain is found in uncharacterised bacterial proteins. It is frequently found in combination with

and

which suggests that it may be involved in DNA binding and recognition. It is predicted to adopt a globular structure consisting of a three-stranded antiparallel β-sheet and α-helices packed on one side of it.
Domain of unknown function DUF7663 (DUF7663)
Type: Domain

This domain is found in uncharacterised bacterial proteins. It is frequently found in combination with

. It is predicted to adopt a complex α/β structure composed of a curved β-sheet that encloses an α-helix and a number of helices packed on its exterior.
Domain of unknown function DUF7664 (DUF7664)
Type: Domain

This entry represents a small accessory domain found at the N-terminal of a small family of archaeal AGOG proteins. These proteins have 8-oxoguanine DNA glycosylase activity.
Bacterial E2-like ubiquitin protein BilB-like (BilB-like)
Type: Family

This protein family includes Bacterial E2-like ubiquitin protein BilB from Collimonas sp. and similar short uncharacterised bacterial proteins. BilB is a component of the Bil (bacterial ISG15-like) antiviral defense system. BilB probably accepts ubiquitin from the BilA-BilD (E1) complex and catalyses its covalent attachment to target protein (CTF) .
Domain of unknown function DUF7666 (DUF7666)
Type: Domain

This entry represents an uncharacterised protein domain that is sometimes found associated with

.
Protein of unknown function DUF7667 (DUF7667)
Type: Family

This entry represents a small family of uncharacterised bacterial proteins. Structure prediction shows these proteins are α-helical with a long central α-helix packed against two shorter N and C-terminal helices. Structure prediction suggests these proteins may form homodimers.
Domain of unknown function DUF7668 (DUF7668)
Type: Domain

This entry represents a bacterial protein domain of unknown function.
Domain of unknown function DUF7669 (DUF7669)
Type: Domain

This domain is found in a group of uncharacterised proteins primarily found in Bacteria. It has a detectable similarity to winged helix HTH domain and it is predicted to adopt similar structure. This domain is frequently found in combination with

and

.
Domain of unknown function DUF7670 (DUF7670)
Type: Domain

This entry represents a family of uncharacterised bacterial membrane proteins that contain four transmembrane α-helices.
Domain of unknown function DUF7671 (DUF7671)
Type: Domain

This entry represents a family of uncharacterised bacterial proteins. The protein forms a single β-barrel domain which shows some structural similarity to the N-terminal domain of the PriA protein. However, structure prediction does not support this protein having a DNA-binding function like PriA.
Protein of unknown function DUF7672 (DUF7672)
Type: Family

This family of uncharacterised proteins is found in bacteria (Bacteroidota and Chloroflexi). Proteins in this family are approximately 80 amino acids in length. The proteins are likely to be integral membrane proteins with two transmembrane α-helices. Structural modelling suggests that these proteins form a dimeric arrangement with the pairs of α helices tilted at close to 45 degrees angle compared to the lipid membrane. Based on the positive inside rule it is likely that the N and C-termini of the proteins have a cytoplasmic location. Given the geometry of the protein complex it may not span the entire membrane.
Domain of unknown function DUF7673 (DUF7673)
Type: Domain

This entry represents an uncharacterised family of proteins, which are typically between 100 and 122 amino acids in length. This protein is often found to be plasmid borne and in a few cases is associated with ParBc domains that are critical for plasmid segregation. This suggests that this domain may play a role in chromosome segregation or plasmid partitioning. Structural modelling suggests this domain will form a homodimeric complex.
Domain of unknown function DUF7674 (DUF7674)
Type: Domain

This family of proteins is found in bacteria. Proteins in this family are typically between 113 and 127 amino acids in length.
Domain of unknown function DUF7675 (DUF7675)
Type: Domain

This entry represents an uncharacterised family of proteins is found in bacteria and viruses. Proteins in this family are typically between 69 and 93 amino acids in length.
Protein of unknown function DUF7676 (DUF7676)
Type: Family

This entry represents a family of bacterial proteins that based on structural similarities are likely to bind to heme or a related derivative molecule. Structural modelling suggests these proteins are likely to form homodimers and that this complex can bind to two heme-like molecules. Each heme binding site is composed of parts of both subunits.
Domain of unknown function DUF7677 (DUF7677)
Type: Domain

This entry represents a group of uncharacterised proteins found in bacteria. These proteins are predicted to adopt globular structure that folds into a three helical bundle.
Domain of unknown function DUF7678 (DUF7678)
Type: Domain

This entry represents a conserved domain of unknown function found in various bacterial species. The domain is approximately 75-100 amino acids in length and contains several highly conserved residues. The function of this domain remains to be determined. Structure prediction suggests this domain is composed of a 6 stranded β-sheet with an α-helix packed on one side.
Protein of unknown function DUF7679 (DUF7679)
Type: Family

This entry represents a small family of Lactobacillus proteins of unknown function. The predicted structure suggests these proteins contain two subdomains, with an N-terminal partly open β barrel and C-terminal α/β subdomain.
Domain of unknown function DUF7680 (DUF7680)
Type: Domain

This entry represents a group of uncharacterised prokaryotic proteins. These proteins share a common semi-conserved EExxWY sequence motif which is predicted as a solvent-exposed in a α/β structure consisting of a four-stranded antiparallel β-sheet and α-helices packed on one side of it.
Acb2/Tad1, hairpin domain (Acb2/Tad1_hairpin)
Type: Domain

This domain, previously known as DUF7681, is found in phage proteins including Anti-CBASS protein 2 (Acb2) and Thoeris anti-defense 1 (Tad1). It folds into an α-helical hairpin that is found either standalone (in Acb2) or in combination with a four-stranded antiparallel β-sheet domain (in Tad1) .

Prokaryotic anti-phage immune systems use TIR and cGAS-like enzymes to produce 1-3-glycocyclic ADP-ribose; and cyclic dinucleotide and trinucleotide signalling molecules, respectively, which limit phage replication. The Thoeris anti-defence proteins Tad1 and Tad2 are both pronged inhibitors and antagonise immunity alongside Anti-CBASS protein 2. These proteins achieve anti-cyclic-oligonucleotide-based anti-phage signalling system (anti-CBASS) activity by sequestering a considerable amount of cyclic nucleotides. Each of these proteins is using distinct binding pockets. The residues conserved in Tad1 and Acb2 are located near these binding sites .
Domain of unknown function DUF7682 (DUF7682)
Type: Domain

This entry represents a small zinc-binding domain found to the N-terminal of proteins that belong to the ParE toxin superfamily. The exact function of this domain is unknown. The zinc ligands are composed of the Cys and His in the N-terminal CGH motif and the Cys residues in the C-terminal CHXC motif.
Domain of unknown function DUF7683 (DUF7683)
Type: Domain

This family represents uncharacterised proteins found in bacteria. These proteins are related to members of

which are described as immunity proteins. They are predicted to adopt similar structure composed of a four-stranded antiparallel β-sheet with α-helices packed on one side of it.
Domain of unknown function DUF7684 (DUF7684)
Type: Domain

This entry represents a group of uncharacterised bacterial proteins found in bacteria. They are predicted to adopt a globular α/β structure that has some similarity to MurD C-terminal domain.
Domain of unknown function DUF7685 (DUF7685)
Type: Domain

This domain is found in uncharacterised bacterial proteins. It contains two pairs of conserved cysteine residues and it is predicted to adopt a fold typical for treble clef zinc fingers. It has a detectable similarity to the N-terminal zinc finger domain of the bacterial AAA+ disaggregase ClpG, which confers extreme heat resistance to bacteria. The latter is is crucial for structural integrity and disaggregase functionality of ClpG.
Domain of unknown function DUF7686 (DUF7686)
Type: Domain

This domain is found in uncharacterised bacterial proteins. It is usually found next to

. It is predicted to adopt α/β structure consisting of a four-stranded β-sheet curved around an α-helix.
Domain of unknown function DUF7687 (DUF7687)
Type: Domain

This entry represents a domain found in uncharacterised bacterial proteins. It shares detectable similarity to a number of type II restriction endonucleases such as DpnII and Ecl18kI and it is predicted to adopt similar structure. It is likely to possess endonuclease activity given the conservation of putative functional site residues.
Domain of unknown function DUF7688 (DUF7688)
Type: Domain

This entry represents a small family of uncharacterised protein found in bacteria. They are predicted to adopt α+β structure defined as β(2)α(2)β(2) structural elements in which the β-strands form an antiparallel β-sheet. The function of these proteins is unknown.
Domain of unknown function DUF7689 (DUF7689)
Type: Domain

This entry represents a group of uncharacterised proteins. They are predicted to adopt a fold typical for cysteine proteinases and topology similar to that of NlpC/P60 family proteins. These proteins are likely enzymes as they have similar active site architecture.
Domain of unknown function DUF7690 (DUF7690)
Type: Domain

This entry represents a domain found in uncharacterised bacterial proteins. It is found N-terminal to

. This domain is predicted to adopt a globular structure composed of four α-helices.
Domain of unknown function DUF7691 (DUF7691)
Type: Domain

This entry represents a group of uncharacterised bacterial proteins. They share detectable similarity to proteins members of

whose function is unknown. Their predicted structures resemble the structure of DNA mimic protein DMP12 but elaborated with additional α-helices.
Domain of unknown function DUF7692 (DUF7692)
Type: Domain

This domain is found in a group of proteins from Halobacteria. It is predicted to adopt a structure that is reminiscent of ribbon-helix-helix fold. Members of this entry are likely to form dimers. They have a stretch of positively charged residues at the N terminus.
Domain of unknown function DUF7693 (DUF7693)
Type: Domain

This entry represents a group of uncharacterised bacterial proteins. They are predicted to adopt a globular structure consisting of a five-stranded antiparallel β-sheet and helices packed on one side of it.
Domain of unknown function DUF7694 (DUF7694)
Type: Domain

This entry represents a domain found in uncharacterised bacterial proteins. They are predicted to adopt a globular structure consisting of an antiparallel β-sheet and α-helix packed on it. Most members contain a highly conserved HhW sequence motif where h is hydrophobic residue.
Domain of unknown function DUF7695 (DUF7695)
Type: Domain

This domain is found in uncharacterised bacterial proteins. It contains a pair of conserved cysteines and it is predicted to adopt a fold which is typical for zinc-ribbon domains.
Protein of unknown function DUF7696 (DUF7696)
Type: Family

This entry represents a small uncharacterised protein family. Members are composed of an N-terminal β-hairpin followed by three α-helices.
Protein of unknown function DUF7697 (DUF7697)
Type: Family

This entry represents a small family of uncharacterised proteins. Although apparently having a bacterial origin these proteins appear in genomic contexts suggesting they are part of an integrated phage genome. Structurally these proteins are composed of a β-hairpin followed by a pair of α-helices.
Domain of unknown function DUF7698 (DUF7698)
Type: Domain

This entry represents a domain from uncharacterised proteins found mainly in Firmicutes. It is predicted to adopt a globular structure consisting of a curved β-sheet and α-helices packed on one side of it. It contains a number of conserved aromatic hydrophobic residues, some of which are predicted to be solvent-exposed.
Domain of unknown function DUF7699 (DUF7699)
Type: Domain

This domain of unknown function is found in Zinc finger CCCH domain-containing protein 62 from Oryza sativa (C3H62) and similar proteins from plants. Members of this family also show a SAP domain (Pfam:PF02037). This domain is predicted to adopt a mainly beta configuration.
Domain of unknown function DUF7700 (DUF7700)
Type: Domain

This domain is usually found in tandem in uncharacterised bacterial proteins. It is predicted to adopt a globular structure consisting of a curved anti-parallel β-sheet and α-helices packed on one side of it. It contains highly conserved aspartate and histidine residues that may constitute a metal binding site.
Domain of unknown function DUF7701 (DUF7701)
Type: Domain

This domain is found in uncharacterised proteins mainly from bacteria. It is predicted to adopt an α-helical structure with a highly conserved DVHDxWxxW sequence motif which may constitute a ligand binding site. This domain is likely to form a homodimer. Investigation of STRING networks suggests this protein may functionally interact with

a likely octameric membrane complex.
Domain of unknown function DUF7702 (DUF7702)
Type: Domain

This entry represents a domain found in uncharacterised proteins mainly from fungi. It has a detectable similarity to domains members of Lipid-translocating exporter superfamily and are predicted to adopt similar structure.
Domain of unknown function DUF7703 (DUF7703)
Type: Domain

This domain is found in a group of uncharacterised proteins mainly from fungi. It is predicted to contain seven transmembrane helices.
Domain of unknown function DUF7704 (DUF7704)
Type: Domain

This domain is found in a group of uncharacterised eukaryotic proteins. It has a detectable similarity to Tumor protein p53-inducible protein 11 (TP53I11) and it is predicted to adopt similar structure.
Domain of unknown function DUF7705 (DUF7705)
Type: Domain

This domain is found in a group of uncharacterised plant proteins. It has remote similarity to some glucanases and it is predicted to adopt similar β-sandwich structure but elaborated with additional strands.
Protein of unknown function DUF7706 (DUF7706)
Type: Family

This entry represents an uncharacterised family of bacterial proteins. Structure prediction (

, AF3 iPTM=0.93) suggests that these proteins form dimers. The monomer is composed of three α helices. STRING provides some weak evidence that these proteins may be immunity proteins or perhaps part of a plasmid addiction system.
Domain of unknown function DUF7707 (DUF7707)
Type: Domain

This domain is found in uncharacterised fungal proteins. It contains a set of highly conserved cysteine residues that are predicted to form disulfide bonds. It is likely that proteins containing this domain are secreted.
Domain of unknown function DUF7708 (DUF7708)
Type: Domain

This domain is found N-terminal in uncharacterised fungal proteins. It shares detectable similarity to the N-terminal domain of NACHT proteins and it is predicted to adopt similar structure.
Domain of unknown function DUF7709 (DUF7709)
Type: Domain

This domain is found in uncharacterised proteins. It is predicted to adopt a globular structure consisting of array of helices followed by a beta-hairpin.
Domain of unknown function DUF7710 (DUF7710)
Type: Domain

This entry represents a small family of uncharacterised bacterial proteins.
Domain of unknown function DUF7711 (DUF7711)
Type: Domain

This entry represents a small family of uncharacterised Actinomycete proteins. These proteins may form homodimers (AlphaFold3 A6WE73 ipTM = 0.79). The dimerisation is mediated by a C-terminal α-helical subdomain.
Domain of unknown function DUF7712 (DUF7712)
Type: Domain

This entry represents a small family of uncharacterised bacterial proteins.
Domain of unknown function DUF7713 (DUF7713)
Type: Domain

This entry represents a protein domain that forms an intimate self-self dimer. The domain is found at the C-terminal of proteins that often have a

domain.
Protein of unknown function DUF7714 (DUF7714)
Type: Family

This entry represents a group of uncharacterised prokaryotic proteins. They are likely to contain two domains that create a compact elongated structure. Toward the C terminus, these proteins have two highly conserved pairs of cysteines which are likely to be involved in metal coordination.
Domain of unknown function DUF7715 (DUF7715)
Type: Domain

This entry represents a family of uncharacterised actinobacterial proteins that are related to

.
Domain of unknown function DUF7716 (DUF7716)
Type: Domain

This domain is found in uncharacterised bacterial proteins either standalone or in combination with other domains. It is predicted to adopt a globular structure consisting of an antiparallel three-stranded β-sheet and α-helices packed on one side of it.
Protein of unknown function DUF7717 (DUF7717)
Type: Family

This entry represents a group of uncharacterised proteins mainly from tailed bacteriophages.
Domain of unknown function DUF7718 (DUF7718)
Type: Domain

This domain is found in uncharacterised prokaryotic proteins. It is predicted to adopt α/β structure consisting of a meander β-sheet and a kinked α-helix. It contains several conserved aspartate and histidine residues that are predicted to come close in space and may constitute a metal binding site.
Domain of unknown function DUF7719 (DUF7719)
Type: Domain

This domain is found in uncharacterised proteins mainly from fungi. It is predicted to fold into three transmembrane helices.
Domain of unknown function DUF7720 (DUF7720)
Type: Domain

This entry represents a small domain found in streptococcal phage proteins. Structurally the domain is composed of a three stranded β-sheet followed by an α-helix.
Domain of unknown function DUF7721 (DUF7721)
Type: Domain

This domain is found in uncharacterised proteins from fungi. It is predicted to adopt globular structure consisting of array of helices.
Domain of unknown function DUF7722 (DUF7722)
Type: Domain

This domain is found in uncharacterised plant proteins. It is predicted to contain helix-extended loop-helix (HeH) structure and has similarity to domains containing this motif.
Domain of unknown function DUF7723 (DUF7723)
Type: Domain

This small family of uncharacterised bacterial proteins are often found adjacent to proteins from

. Structure prediction shows that these proteins are very likely to form a complex.
Domain of unknown function DUF7724 (DUF7724)
Type: Domain

This entry represents a family of bacterial proteins composed of an all β strand domain composed of 7 β-strands. Structure prediction suggests that these proteins will form a complex with proteins from

.
Domain of unknown function DUF7725 (DUF7725)
Type: Domain

This domain is found in uncharacterised plan proteins. It has detectable similarity to winged helix HTH domains and it is predicted to adopt similar structure.
Domain of unknown function DUF7726 (DUF7726)
Type: Domain

This domain is found in uncharacterised fungal proteins. It has detectable similarity to HTH domains and it is predicted to adopt similar structure.
Domain of unknown function DUF7727 (DUF7727)
Type: Domain

This domain is found in uncharacterised fungal proteins. It has detectable similarity to proteins members of the Cytochrome b558 subunit alpha family and it is predicted to adopt similar structure composed of four helices.
Domain of unknown function DUF7728 (DUF7728)
Type: Domain

This domain is found in uncharacterised fungal proteins. It is predicted to fold into a β-sandwich. It contains highly conserved cysteine residues that are predicted to form a disulfide bond.