SII-SWORD/CoKE huggingface dataset:
Protein of unknown function DUF7446 (DUF7446)
Type: Family

This entry represents a highly conserved domain found in various bacteriophages, particularly those infecting Salmonella and related bacteria. The domain is also present in some bacterial species, suggesting possible horizontal gene transfer. The function is unknown, but the high degree of conservation implies an important role in phage biology. A conserved motif DVT is present centrally in many family members. The aspartate and threonine form side chain hydrogen bonds that help stabilise the dimeric interaction. Structure prediction suggests these proteins form a confident homodimer (iPTM=0.83).
Protein of unknown function DUF7447 (DUF7447)
Type: Family

This entry represents an uncharacterised family found in various bacteriophage proteins. It is predominantly found in phages infecting diverse bacterial species including Burkholderia, Bacillus, Streptomyces, Listeria, and Caulobacter. The proteins are typically around 100-150 amino acids in length. Many of the proteins containing this domain are annotated as uncharacterised or hypothetical proteins. The proteins form a compact domain composed of a four stranded antiparallel β-sheet.
Domain of unknown function DUF7448 (DUF7448)
Type: Domain

This entry represents a conserved viral protein domain of unknown function. The domain is approximately 130-160 amino acids in length and is found in various bacteriophages and large DNA viruses. The alignment shows several conserved residues, including a highly conserved DCC motif. The protein contains a β-sandwich structural domain.
Domain of unknown function DUF7449 (DUF7449)
Type: Domain

This entry represents a small family of uncharacterised proteins found in pseudomonas phage. The protein contains a compact domain composed of two α-helices followed by four β-strands that form a β-sheet.
Domain of unknown function DUF7450 (DUF7450)
Type: Domain

This entry represents a group of uncharacterised proteins from bacteria that, according to structure predictions (

or

), they may contain novel repeats that fold into twisted long β-hairpins different from typical β-barrel hairpins and they do not exhibit homology to any β-barrel.
Domain of unknown function DUF7451 (DUF7451)
Type: Domain

This entry represents a presumed domain found in a group of uncharacterised sequences from bacteria. According to structure predictions, this domain may adopt and all-beta configuration with beta-strands of different lengths. This domain is usually associated with DUF7450 (Pfam:PF24247).
Domain of unknown function DUF7452 (DUF7452)
Type: Domain

This entry represents a presumed domain found in a group of uncharacterised proteins from bacteria. This domain may adopt an all-beta configuration.
Protein of unknown function DUF7453 (DUF7453)
Type: Family

This entry represents a group of uncharacterised sequences from bacteria. According to structure predictions, these proteins may comprise novel repeats consisting of an arrangement of four beta-strands in which the second one is longer and curved. This arrangement is repeated eight times in SwissProt:A0A5B9QB27, which form a closed repeat.
Domain of unknown function DUF7454 (DUF7454)
Type: Domain

This entry represents a small family of uncharacterised proteins from a set of mycobacterial phage including phage Bxb1 (gene 86). The members of the family range in length from 50 to 90 residues. Structurally, the domain shows some weak similarity to the N-terminal domain of IF5, which adopts an SH3 like barrel fold.
Domain of unknown function DUF7455 (DUF7455)
Type: Domain

This entry represents a family of uncharacterised actinobacterial zinc binding domains. The proteins contain a characteristic CXHH motif. Only the second of those two histidines acts as the zinc ligand according to structure prediction (ipTM = 0.94).
Protein of unknown function DUF7456 (DUF7456)
Type: Family

This entry represents a family of uncharacterised proteins found in Mycobacterial phage. The family includes gene 48 from phage Bxb1.
Protein of unknown function DUF7457 (DUF7457)
Type: Family

This entry represents a small family of uncharacterised phage proteins. This family includes gene 78 from Phage Bxb1.
Protein of unknown function DUF7458 (DUF7458)
Type: Family

This entry represents a small family of uncharacterised mycobacterial phage. Some members are annotated as DNA primase. The family includes gene 53 from phage Bxb1.
Domain of unknown function DUF7459 (DUF7459)
Type: Domain

This entry represents an uncharacterised protein domain found in a mycobacterial phage proteins. These domains form a zinc binding cluster where 8 cysteine and histidine residues bind two zinc ions according to structure prediction (iPTM=0.87).
Protein of unknown function DUF7460 (DUF7460)
Type: Family

This entry represents a small uncharacterised mycobacterial phage composed of two α-helices and three β-strands. The family includes Phage Bxb1 gene 81.
Protein of unknown function DUF7461 (DUF7461)
Type: Family

This entry represents a small uncharacterised family of mycobacterial phage proteins. The family includes gene 71 from phage Bxb1

. Structure prediction suggests this protein may form a pair of α-helices that form a helical hairpin structure.
Protein of unknown function DUF7462 (DUF7462)
Type: Family

This entry represents a family of uncharacterised mycobacterial phage proteins. The family includes Phage Bxb1 gene 76. These proteins are short around 40 residues in length.
Protein of unknown function DUF7463 (DUF7463)
Type: Family

This entry represents a small family of uncharacterised mycobacterial phage proteins. The family includes gene 82 from mycobacterial phage Bxb1.
Domain of unknown function DUF7464 (DUF7464)
Type: Domain

This entry represents a small family of uncharacterised phage proteins. The family includes the gene 83 from the mycobacterial phage Bxb1

. This family shows structural similarity to

. These proteins have an SH3-like barrel structure.
Protein of unknown function DUF7465 (DUF7465)
Type: Family

This entry represents a small family of uncharacterised phage proteins. The family includes Phage Bxb1 protein 85

.
Protein of unknown function DUF7466 (DUF7466)
Type: Family

This entry represents a family of uncharacterised phage proteins. Structurally these are composed of a pair of α-helices. Structure prediction suggests these proteins may homodimerise (iPTM=0.89). These proteins are annotated as RDF proteins but the source of this annotation is uncertain.
Domain of unknown function DUF7467 (DUF7467)
Type: Domain

This entry represents a β-sandwich domain found in a variety of bacterial cell surface proteins.
Protein of unknown function DUF7468 (DUF7468)
Type: Family

This entry represents a conserved protein family found in cyanophages that infect marine Synechococcus and Prochlorococcus. The function of this protein is unknown. It is typically 70-100 amino acids in length. The protein appears to be specific to cyanophages and is not found in their cyanobacterial hosts.
Protein of unknown function DUF7469 (DUF7469)
Type: Family

Members of this family are uncharacterised proteins found in cyanobacteria that grow with a filamentous morphology .
Protein of unknown function DUF7470 (DUF7470)
Type: Family

This family includes a group of short proteins from archaea. Members are predicted to adopt an α-helical structure.
Protein of unknown function DUF7471 (DUF7471)
Type: Family

This family includes a group of short proteins from archaea.
Protein of unknown function DUF7472 (DUF7472)
Type: Family

This family includes a group of short proteins from archaea. Members are predicted to adopt an α-helical structure.
Protein of unknown function DUF7473 (DUF7473)
Type: Family

This family includes a group of proteins from archaea. Members are predicted to adopt an α-helical structure.
Protein of unknown function DUF7474 (DUF7474)
Type: Family

This family includes a group of proteins from archaea. Members are predicted to adopt a mainly α-helical structure.
Protein of unknown function DUF7475 (DUF7475)
Type: Family

This family includes a group of proteins from archaea. Members are predicted to adopt an α-helical structure.
Protein of unknown function DUF7476 (DUF7476)
Type: Family

This family includes a group of proteins from nematodes.
Domain of unknown function DUF7477 (DUF7477)
Type: Domain

This entry represents a domain consisting of a novel repeat fold which contains five repeats, each of them comprising three antiparallel β-strands and a short α-helix, according to structure predictions (e.g

). This domain is mainly found in plant sequences, including casein kinase 1-like protein HD16 from rice, a protein involved in the regulation of flowering time through gibberellin (GA) signalling and independently of photoperiod .
Domain of unknown function DUF7478 (DUF7478)
Type: Domain

This entry represents a domain containing a novel repeat fold, according to structure predictions. It may comprise six repeats, each of them consisting of two antiparallel β-strands and a short α-helix.
Domain of unknown function DUF7479 (DUF7479)
Type: Domain

This domain is found in uncharacterised bacterial proteins. It contains four invariant cysteines and it is predicted to adopt a Zn-ribbon fold.
Domain of unknown function DUF7480 (DUF7480)
Type: Domain

This domain is found in uncharacterised bacterial proteins. These proteins contain a highly conserved lipoprotein-type signal peptide sequence at the N terminus and two invariant cysteine residues within this domain suggesting their extracytoplasmic localisation.
Domain of unknown function DUF7481 (DUF7481)
Type: Domain

This entry represents a group of uncharacterised sequences from bacteria. They may consist on repeats with a novel fold which is organised in three units with twisted β-strands each.
Domain of unknown function DUF7482 (DUF7482)
Type: Domain

This entry includes a group of uncharacterised sequences from bacteria and archaea, which, according to structure predictions, they may have a novel repeat fold. They may consist of 5-6 antiparallel β-strands decorated with short α-helices.
Domain of unknown function DUF7483 (DUF7483)
Type: Domain

This entry includes uncharacterised sequences mainly from bacteria and viruses that may adopt a novel fold consisting on three repeat units, each of them are a type of β-sandwich with three β-strands on one side and four or five on the other.
Protein of unknown function DUF7484 (DUF7484)
Type: Family

This entry represents an uncharacterised family of phage proteins. These proteins consist of two domains. The first is composed of four α-helices that are contributed by both the N and C-terminal of the protein. The second domain is a central β domain. Structure prediction suggests that these proteins might form a large homo-oligomeric ring of 8-10 subunits, but the iPTM scores are marginal.
Domain of unknown function DUF7485 (DUF7485)
Type: Domain

This entry includes uncharacterised sequences mainly from actinobacteria. According to structure predictions, they may form a β-propeller-like fold consisting of four repeated units containing three (in one of them) and four (on the other three units) β-strands. There is an additional unit which is slightly different that resembles a seven stranded β-sandwich.
Domain of unknown function DUF7486 (DUF7486)
Type: Domain

This entry represents a group of uncharacterised sequences that, according to structure predictions, they may consist on a novel repeat fold which comprises β-hairpin-β units organised in four and five units, forming two domains.
Domain of unknown function DUF7487 (DUF7487)
Type: Domain

This entry represents a group of uncharacterised sequences mainly from viruses. They may have a novel repeat fold consisting of two domains at the N- and C-terminal with β-hairpin-β-α configuration that are connected by nine α-helices linked by loops.
Domain of unknown function DUF7488 (DUF7488)
Type: Domain

This entry represents a domain from uncharacterised proteins found mainly in Campylobacterota. Members of this entry contain two highly conserved cysteine residues.
Domain of unknown function DUF7489 (DUF7489)
Type: Domain

This entry represents a domain from uncharacterised proteins mainly found in Actinomycetes. They are predicted to adopt an OB fold-like β-barrel.
Domain of unknown function DUF7490 (DUF7490)
Type: Domain

This domain is found in uncharacterised archaeal proteins. Members of this family have a PGF-CTERM motif

at the C-terminal.
Domain of unknown function DUF7491 (DUF7491)
Type: Domain

This is a coiled-coil region found at the C-terminal of a group of uncharacterised sequences from fungi.
Domain of unknown function DUF7492 (DUF7492)
Type: Domain

This entry represents a domain of unknown function found in fungal sequences. It may adopt a Ig-like fold similar to that in Auxiliary Activity family 9 (AA9),

.
Domain of unknown function DUF7493 (DUF7493)
Type: Domain

This is a domain of unknown function found in uncharacterised sequences from fungi. Some of these sequences are annotated as sphingosine kinases. This domain may adopt a PH-like fold.
Domain of unknown function DUF7494 (DUF7494)
Type: Domain

This domain is found in a group of uncharacterised proteins mainly from Epsilonproteobacteria. It is predicted to adopt a globular structure with a β-sandwich topology.
Domain of unknown function DUF7495 (DUF7495)
Type: Domain

This domain is found in a group of uncharacterised eukaryotic proteins. It contains six highly conserved cysteines which are predicted to form disulfide bonds. This domain is predicted to adopt structure similar to C-type lectins.
Domain of unknown function DUF7496 (DUF7496)
Type: Domain

This domain is found in a group of uncharacterised eukaryotic proteins. It is predicted to fold into Ig-like β-sandwich.
Domain of unknown function DUF7497 (DUF7497)
Type: Domain

This domain is found in a group of uncharacterised eukaryotic proteins. It contains two highly conserved cysteines. This domain is predicted to fold into Ig-like β-sandwich.
Domain of unknown function DUF7498 (DUF7498)
Type: Domain

This domain is found in a group of uncharacterised eukaryotic proteins. It contains two highly conserved cysteines. This domain is predicted to fold into Ig-like β-sandwich.
Protein of unknown function DUF7499 (DUF7499)
Type: Family

This entry represents uncharacterised proteins found in Chlamydiia. They adopt a globular α/β structure consisting of a curved mixed β-sheet and α-helices packed on both sides (

). Most members of this family contain an N-terminal membrane lipoprotein attachment site.
Protein of unknown function DUF7500 (DUF7500)
Type: Family

This entry represents a family of uncharacterised archaeal proteins. They contain three highly conserved negatively charged (aspartate and glutamate) residues.
Protein of unknown function DUF7501 (DUF7501)
Type: Family

This entry represents a group of uncharacterised proteins found in Halobacteria. They contain three invariant cysteine residues and a histidine that probably constitute a metal binding site. These proteins are probably C2HC zinc fingers that are variant of the classical C2H2 zinc finger domains.
Protein of unknown function DUF7502 (DUF7502)
Type: Family

This entry represents a group of uncharacterised archaeal proteins.
Protein of unknown function DUF7503 (DUF7503)
Type: Family

This entry represents a group of uncharacterised archaeal proteins. These proteins are short in size (~50 residues long), contain a highly hydrophobic helix and are likely associated with the membrane.
Protein of unknown function DUF7504 (DUF7504)
Type: Family

This entry represents a group of uncharacterised archaeal proteins. They contain the typical P-loop motif and are probably structurally related to the P-loop NTPases.
Cadherin EGF LAG seven-pass G-type receptor fmi-1, DUF7505 (Fmi-1_DUF7505)
Type: Domain

This domain of unknown function is found ant the N-terminal of Cadherin EGF LAG seven-pass G-type receptor fmi-1 from Caenorhabditis elegans and in similar uncharacterised proteins from nematodes. Fmi-1 is required for axon fasciculation and navigation during ventral cord development, mediating both pioneer and follower axon extension, guidance and track formation .
This domain contain a semi-conserved PPChHPGQ motif (where h is a hydrophobic residue) and is predicted to fold into a incomplete β-sandwich.
Domain of unknown function DUF7506 (DUF7506)
Type: Domain

This domain is found in a group of uncharacterised proteins from parasitic secernentean nematodes. It is predicted to adopt an OB-fold.
Domain of unknown function DUF7508 (DUF7508)
Type: Domain

This domain is found in uncharacterised prokaryotic proteins. Is has significant sequence similarity to GIY-YIG endonuclease domains and it is predicted to adopt similar structure.
Domain of unknown function DUF7509 (DUF7509)
Type: Domain

This domain is found in a group of uncharacterised proteins from Halobacteria. It has detectable sequence similarity to domains members of the N-(deoxy)ribosyltransferase-like superfamily and it is predicted to adopt similar structure.
Protein of unknown function DUF7510 (DUF7510)
Type: Family

This entry represents a family of uncharacterised archaeal proteins. They are predicted to have a structure composed of seven nearly orthogonally packed strands, four of which are located at the N-terminal and three at the C-terminal. The N- and C-terminal strands clamp to form a β-sandwich. They are separated by a ~50 aa long disordered region which contains a repetitive SPY sequence motif.
Domain of unknown function DUF7511 (DUF7511)
Type: Domain

This domain is found in a group of uncharacterised archaeal proteins. It is predicted to fold into a three-stranded antiparallel β-sheet. It contains a highly conserved tryptophan residue located at the beginning of the third β-strand.
Protein of unknown function DUF7512 (DUF7512)
Type: Family

This entry represents a family of small uncharacterised proteins from Halobacteria. They are predicted to fold into a single α-helix and contain a highly conserved LYxGYG sequence motif.
Domain of unknown function DUF7513 (DUF7513)
Type: Domain

This domain is found in uncharacterised proteins from Halobacteria. It has a detectable sequence similarity to TRAM domains and it is predicted to adopt a similar structure. It is found as standalone domain.
Domain of unknown function DUF7514 (DUF7514)
Type: Domain

This domain is found in uncharacterised eukaryotic proteins. It is predicted to adopt a globular structure composed of α-helices.
Domain of unknown function DUF7515 (DUF7515)
Type: Domain

This domain is found in a group of uncharacterised metazoan proteins. It has a detectable sequence similarity to HTH winged helix domains and it is predicted to adopt similar structure.
Domain of unknown function DUF7516 (DUF7516)
Type: Domain

This domain is found in a group of uncharacterised metazoan proteins. It has a detectable sequence similarity to HTH winged helix domains and it is predicted to adopt similar structure. In some proteins, this domain is found two copies and usually associated with

.
Domain of unknown function DUF7517 (DUF7517)
Type: Domain

This domain is found in a group of uncharacterised metazoan proteins. It is predicted to adopt a structure typical for HTH winged helix domains. This domain is usually found associated with

and

.
Protein of unknown function DUF7518 (DUF7518)
Type: Family

This family includes a group of short proteins from archaea. Members are predicted to adopt an α-helical structure at the N terminus and show a disordered C-terminal region. In some lineages of archaea, the gene encoding these proteins is found upstream of SMC (chromosome segregation protein).
Protein of unknown function DUF7519 (DUF7519)
Type: Family

This family includes a group of proteins from archaea. Members are predicted to adopt a mainly α-helical structure.
Protein of unknown function DUF7520 (DUF7520)
Type: Family

This family includes a group of proteins from archaea.
Protein of unknown function DUF7521 (DUF7521)
Type: Family

This family includes a group of proteins from archaea.
Protein of unknown function DUF7522 (DUF7522)
Type: Family

This family includes a group of proteins from archaea. Members are predicted to adopt an α-β structure.
Protein of unknown function DUF7523 (DUF7523)
Type: Family

This family includes a group of proteins from archaea. Members are predicted to be organised into two domains, an N-terminal with an all-α configuration and a C-terminal with an α-β structure.
Protein of unknown function DUF7524 (DUF7524)
Type: Family

This family includes a group of proteins from archaea. Members are predicted to be organised into two domains, an N-terminal with an all-beta configuration and a C-terminal with a mainly alpha-structure.
Protein of unknown function DUF7525 (DUF7525)
Type: Family

This family includes a group of short archaeal proteins. Members are predicted to adopt an α-helical configuration.
Protein of unknown function DUF7526 (DUF7526)
Type: Family

This family includes a group of short archaeal proteins. Members are predicted to adopt an α-β configuration.
Domain of unknown function DUF7527 (DUF7527)
Type: Domain

This domain of unknown function is found at the C-terminal end of a group of archaeal proteins. It is predicted to adopt an α-β structure.
Protein of unknown function DUF7528 (DUF7528)
Type: Family

This family includes a group of proteins from archaea. Members are predicted to adopt an α-β structure.
Protein of unknown function DUF7529 (DUF7529)
Type: Family

This family includes a group of proteins from archaea. Members are predicted to adopt an α-β structure.
Protein of unknown function DUF7530 (DUF7530)
Type: Family

This family includes a group of proteins from archaea. Members are predicted to adopt an all-alpha structure.
Protein of unknown function DUF7531 (DUF7531)
Type: Family

This family includes a group of proteins from archaea. Members are predicted to adopt an α-β structure.
Protein of unknown function DUF7532 (DUF7532)
Type: Family

This family includes a group of proteins from archaea. Members are predicted to adopt an α-β structure.
Protein of unknown function DUF7533 (DUF7533)
Type: Family

This family includes a group of proteins from archaea. Members are predicted to adopt an α-helical structure.
Protein of unknown function DUF7534 (DUF7534)
Type: Family

This family includes a group of proteins from archaea. Members are predicted to adopt an α-helical structure.
Protein of unknown function DUF7535 (DUF7535)
Type: Family

This family includes a group of proteins from archaea. Members are predicted to adopt an alpha structure.
Protein of unknown function DUF7536 (DUF7536)
Type: Family

This family includes a group of short proteins from archaea.
Protein of unknown function DUF7537 (DUF7537)
Type: Family

This family includes a group of proteins from archaea. Members are predicted to adopt a mainly beta structure.
Protein of unknown function DUF7538 (DUF7538)
Type: Family

This family includes a group of proteins from archaea. Members are predicted to adopt an α-β structure.
Protein of unknown function DUF7539 (DUF7539)
Type: Family

This family includes a group of proteins from archaea. Members are predicted to adopt a mainly alpha structure.
Domain of unknown function DUF7540 (DUF7540)
Type: Domain

This entry represents a small family of uncharacterised enterobacterial phage proteins. These proteins adopt a compact domain composed of a small three stranded β-sheet, with an α-helix inserted between the first and second strand.
Protein of unknown function DUF7541 (DUF7541)
Type: Family

This entry represents a family of uncharacterised proteins found mainly in Halobacteria. They are predicted to adopt a structure consisting of four α-helices.
Protein of unknown function DUF7542 (DUF7542)
Type: Family

This entry represents a family of small uncharacterised proteins found mainly in Halobacteria. They are predicted to adopt a globular α/β structure consisting of three-stranded β-sheet and two α-helices one of which is packed on the β-sheet.