SII-SWORD/CoKE huggingface dataset:
Domain of unknown function DUF6948 (DUF6948)
Type: Domain

This domain is found either as standalone or in combination with other domains in a group of uncharacterised proteins. It is distantly related to EDC3 mRNA-decapping protein 3 and it could be involved in RNA-binding. It is predicted to adopt a barrel-like structure with a typical Sm-like fold. The pair of glycines responsible for maintaining the Sm-barrel curvature are also conserved in the members of this family.
Protein of unknown function DUF6951 (DUF6951)
Type: Family

This is a family of uncharacterised proteins found in archaea and bacteria. These proteins are predicted to adopt similar structure to the members of SufE/NifU superfamily. They contain three invariant cysteine residues and a fourth semi-conserved residue either cysteine or histidine. These residues are likely to define a potential Zn-binding site similar to the binding site observed in SufU.
Protein of unknown function DUF6953 (DUF6953)
Type: Family

This is a family of uncharacterised bacterial proteins. They share significant sequence similarity to HTH winged helix domains, in particular to the N-terminal domain of transcriptional regulator BrxR and RNA polymerase III subunit RPC82.
Protein of unknown function DUF6954 (DUF6954)
Type: Family

This is a family of uncharacterised proteins from Firmicutes. They are enriched in hydrophobic residues and are likely associated with the membrane.
Protein of unknown function DUF6955 (DUF6955)
Type: Family

This is a family of small uncharacterised proteins found in bacteria and archaea. They are predicted to adopt an α/β globular structure consisting of a cradle-like β-sheet and α-helices packed on the convex side of the sheet.
Domain of unknown function DUF6956 (DUF6956)
Type: Domain

This domain is found in uncharacterised bacterial proteins either as standalone or in combination with other domains. It is predicted to adopt an α/β structure with ferredoxin-like topology.
Domain of unknown function DUF6957 (DUF6957)
Type: Domain

This domain is found in uncharacterised bacterial proteins. It is predicted to fold into a β-barrel that has some similarity to the replication focus targeting sequence (RFTS) domain of Dnmt1 methyltransferase 1.
Protein of unknown function DUF6958 (DUF6958)
Type: Family

This family is found in uncharacterised bacterial proteins. They share sequence similarity with several HTH winged helix domains, one of which Zinc uptake regulation protein FurB.
Protein of unknown function DUF6961 (DUF6961)
Type: Family

This is a family of small, about 60 residues in length, proteins found mainly in alphaproteobacteria. They are predicted to adopt a globular structure consisting of three helices. The N- and C-terminal helices contain highly conserved aromatic residues in addition to the nearly invariant glycines located at the interhelical connecting loops.
Protein of unknown function DUF6962 (DUF6962)
Type: Family

This is a family of uncharacterised proteins. They are related to HlyIII family

and are predicted to adopt the same structure consisting of seven transmembrane helices. Their predicted structure, suggests that, similarly to HlyIII, they may contain a Zn-binding site, albeit slightly rearranged as only two of the Zn-coordinating residues are in conserved positions.
Domain of unknown function DUF6963 (DUF6963)
Type: Domain

This domain is found N-terminal in uncharacterised bacterial proteins. It is distantly related to class-II glutamine amidotransferase domains

.
Domain of unknown function DUF6964 (DUF6964)
Type: Domain

This short helical domain is found in a small set of ribosomal S1 proteins from Rhodothermales species. It's function is unknown.
Domain of unknown function DUF6965 (DUF6965)
Type: Domain

This entry represents a domain found in a group of uncharacterised proteins which are predicted to form a small three helical bundle containing a β-hairpin between helices 1 and 2.
Domain of unknown function DUF6966 (DUF6966)
Type: Domain

This is a domain found in uncharacterised bacterial proteins that is predicted to be helical. It contains a nearly invariant tryptophan towards the N-terminal and a highly conserved motif [F/Y]GGMGSx(2)D towards the C-terminal.
Protein of unknown function DUF6967 (DUF6967)
Type: Family

This family of proteins is found in proteobacteria. Proteins in this family are approximately 70 amino acids in length. They are predicted to fold into a four-stranded β-sheet meander and an α-helix. One face of this β-sheet is enriched with conserved positively charged arginine and lysine residues.
Domain of unknown function DUF6968 (DUF6968)
Type: Domain

This domain is found in uncharacterised bacterial proteins either standalone or C-terminal to HTH winged helix domains. It has a partial sequence similarity to ribosome associated factors that are members of

.
Domain of unknown function DUF6969 (DUF6969)
Type: Domain

This domain is found in uncharacterised proteins mainly from Proteobacteria. It is predicted to adopt an α/β globular structure. It has three highly conserved histidines that are predicted to cluster together in space and are likely involved in metal coordination.
Domain of unknown function DUF6970 (DUF6970)
Type: Domain

This domain is found in uncharacterised proteins from bacteria and protostome animals. It is predicted to fold into a curved meander β-sheet. It contains four highly conserved cysteine residues, two of which are predicted to cluster together in space and are likely to be involved in disulfide bond formation.
Domain of unknown function DUF6971 (DUF6971)
Type: Domain

This is a domain of unknown function found at the N-terminal end of uncharacterised proteins from Gammaproteobacteria.
Domain of unknown function DUF6972 (DUF6972)
Type: Domain

This domain is found in uncharacterised cyanobacterial proteins either standalone or in combination with other domains. It is probably distantly related to the C-terminal domain of CdiA toxin (CdiA-CT), known member of RNase A superfamily.
Domain of unknown function DUF6973 (DUF6973)
Type: Domain

This domain is found in uncharacterised bacterial proteins including the Putative protein RhsE

. It is predicted to adopt a globular structure consisting of five α-helices. It is probably distantly related to Wnt domains.
Domain of unknown function DUF6974 (DUF6974)
Type: Domain

This entry represents a dimeric α/β barrel domain from an uncultured marine organism

and related proteins from Alphaproteobacteria. The function of this family is unknown.
Protein of unknown function DUF6975 (DUF6975)
Type: Family

This family of uncharacterised proteins is found in Alphaproteobacteria. It shares significant sequence similarity with enzymes, members of Heme oxygenase-like superfamily

and are predicted to adopt similar structure consisting of a bundle of six α-helices.
Protein of unknown function DUF6976 (DUF6976)
Type: Family

This family of uncharacterised proteins is found mostly in Proteobacteria. It is likely to consists of two domains that engage in extensive contacts mainly via hydrophobic residues. The predicted structure of the N-terminal domain has similarity to chorismatases.
Domain of unknown function DUF6981 (DUF6981)
Type: Domain

This entry represents an alpha-lytic protease prodomain-like domain present in a protein of unknown function from Desulfovibrio piger. Its structure has been characterised

.
Protein of unknown function DUF6982 (DUF6982)
Type: Family

This family of proteins is found in bacteria. Proteins in this family are typically between 135 and 1024 amino acids in length. This family of proteins are structurally related to

a family of transcriptional repressors of phase-1 flagellin genes. The family appears to contain two related subdomains with SH3-like fold.
Cyanophage baseplate Pam3 plug gp18 (Pam3_gp18)
Type: Domain

This family, previously known as DUF6983, represents Cyanophage baseplate Pam3 plug gp18 and related proteins. Gp18 has structural similarity to a component of the baseplate Complex for Myoviridae Phage XM1. The cyanophage Pam3 has a substantially simpler molecular organisation than the prototypical, contractile-tail bacteriophage T4, but it retains the essential elements required for DNA injection. The baseplate of Pam3 contains six protein components: the trimeric spike gp20, the trimeric hub gp19, the baseplate wedge (six heterotriplexes of gp22-gp23), the plug of six gp18 monomers, and the fibers (12 trimers of gp24)

. The plug gp18 consists of two-layered β-sheets and a C-terminal α-helix, resembling the immunoglobin fold. Each plug monomer is embedded between the two C-terminal helices of the tube initiator, forming a 'plug' to fix the core helical bundle of the wedge onto the hub .
Domain of unknown function DUF6984 (DUF6984)
Type: Domain

This entry represents a bacterial family of unknown function. They are predicted to adopt a globular α/β structure.
Domain of unknown function DUF6985 (DUF6985)
Type: Domain

This entry represents bacterial domain of unknown function.
Protein of unknown function DUF6986 (DUF6986)
Type: Family

This entry represents a family of bacterial TIM barrel proteins that are most closely related to

. This strongly suggests that these proteins are enzymes with a possibly related function.
Domain of unknown function DUF6987 (DUF6987)
Type: Domain

This α-helical domain is usually found at the C-terminal of proteins containing repeats of

.
Protein of unknown function DUF6988 (DUF6988)
Type: Family

This family of uncharacterised proteins is found mainly in Proteobacteria. These proteins are predicted to adopt an α-helical structure. They contain a highly conserved RXXXE-motif and an invariant histidine that may have a functional role.
Domain of unknown function DUF6989 (DUF6989)
Type: Domain

This domain is found in a number of uncharacterised bacterial proteins that are likely associated with the membrane.
Protein of unknown function DUF6990 (DUF6990)
Type: Family

This family of proteins is found in bacteria. Proteins in this family are typically between 185 and 199 amino acids in length. There are two semi-conserved sequence motifs: HLA and GFVPYI.
Domain of unknown function DUF6991 (DUF6991)
Type: Domain

This entry represents a C-terminal domain of a functionally unknown conserved protein from Bacillus anthracis

and related proteins from Bacillus.
Protein of unknown function DUF6992 (DUF6992)
Type: Family

This is a family of uncharacterised bacterial proteins. They are enriched with hydrophobic residues and are likely associated with the membrane. These proteins contain two conserved motifs GLDxxYxxxG and FLxxFD.
Domain of unknown function DUF6993 (DUF6993)
Type: Domain

This entry represents a bacterial domain of unknown function. It is predicted to adopt α+β structure consisting of four-stranded atiparallel beta-shsheet and α-helix that packs on it.
Protein of unknown function DUF6994 (DUF6994)
Type: Family

This is a family of uncharacterised bacterial proteins. They are probably remotely related to His-Me finger endonucleases. The conservation of the putative active site residues in this family is not strict, in particular the position of the catalytic histidine. The residues involved in metal coordination are conserved. The presence in the vicinity of two invariant aspartate residues that point toward the putative active site suggests that these proteins may still function as enzymes but probably via a somewhat different catalytic mechanism. They may still retain their catalytic activity by employing these conserved aspartates that in the predicted AF2 models are well positioned to undertake a role in a potential nucleophilic attack.
PolB1 binding protein 2 (PBP2)
Type: Family

This is a family of archaeal proteins, previously known as DUF6995, representing homologues of PolB1 binding protein 2 (PBP2). PBP2, is a subunit of PolB1 enzyme that is a member of the archaeal B-family of DNA polymerases. PBP2 along with PBP1, associate with distinct surfaces of the larger catalytic subunit and influence the enzymatic properties of the DNA polymerase . Members of this family adopt a winged helix (HTH) fold (

).
Domain of unknown function DUF6996 (DUF6996)
Type: Domain

This domain is found N-terminal in a group of uncharacterised proteins. It is remotely related to AbiEi winged helix domain and it is predicted to adopt the same structure. This domain is usually associated with

which is related to PD-(D/E)XK nucleases.
Domain of unknown function DUF6997 (DUF6997)
Type: Domain

This domain is found C-terminal in a group of uncharacterised proteins mainly bacterial. It usually follows winged helix domain

. This domain is related to PD-(D/E)XK nucleases and it is predicted to adopt the same structure with similar active site architecture.
Domain of unknown function DUF6998 (DUF6998)
Type: Domain

This domain is found in uncharacterised bacterial proteins either standalone or in combination with other domains. It shares significant sequence similarity with PvuII endonucleases (

) and is predicted to adopt similar structure. The predicted structures, however, do not suggest similarity in the active site architecture.
Protein of unknown function DUF6999 (DUF6999)
Type: Family

This is a family of uncharacterised prokaryotic proteins. They are predicted to adopt α-helical structure. These proteins contain several invariant histidines and aspartates that may have a functional role.
Domain of unknown function DUF7000 (DUF7000)
Type: Domain

This domain is found in uncharacterised archaeal proteins. It is predicted to adopt an α/β structure consisting of a cradle-like β-sheet with α-helices pocked on the convex side of it. It contains a highly conserved GYMDFTYF sequence motif that may be of functional importance.
Protein of unknown function DUF7001 (DUF7001)
Type: Family

This is a family of uncharacterised proteins found in Archaea. They have sequence similarity to Zincin-like metalloproteases and are predicted to adopt the same structure. Only one of the two zinc binding sites are conserved suggesting that these proteins may possess different function.
Protein of unknown function DUF7002 (DUF7002)
Type: Family

This is a family of uncharacterised bacterial proteins. They share some sequence similarity with DarT toxin (

) and are likely to adopt the same structure.
Protein of unknown function DUF7003 (DUF7003)
Type: Family

This is a family of uncharacterised bacterial proteins. It is predicted to adopt a globular α/β structure with a central antiparallel β-sheet and helices packed on it.
Protein of unknown function DUF7004 (DUF7004)
Type: Family

This family of proteins is found in mainly bacteria. Proteins in this family are approximately 160 amino acids in length. They are predicted to adopt globular α/β structure. These proteins contain two highly conserved sequence motifs GxFDxWC and KRxKRLG that may be of functional importance.
Protein of unknown function DUF7005 (DUF7005)
Type: Family

This is a family of uncharacterised bacterial proteins. These proteins share partial sequence similarity to the collagenase catalytic core with invariant HExxH motif.
Family of unknown function DUF7006 (DUF7006)
Type: Family

Proteins in this family are found in Firmicutes. They are approximately 120 amino acids in length and are predicted to adopt an α-helical structure. Members of this family contain two highly conserved acid residues aspartate and glutamate.
Domain of unknown function DUF7007 (DUF7007)
Type: Domain

This domain is found in uncharacterised bacterial proteins. It is predicted to adopt a globular structure consisting of segregated α-helices and a five-stranded antiparallel β-sheet. This domain contains two highly conserved sequence motifs TxxHGG and YEED that may be of a functional importance.
Domain of unknown function DUF7008 (DUF7008)
Type: Domain

This domain is found in uncharacterised bacterial proteins. It contains a number of highly conserved positively charged residues that may have a functional role. This domain is frequently found in combination with

.
Domain of unknown function DUF7012 (DUF7012)
Type: Domain

This domain of unknown function is found in a group of proteins mainly from alphaproteobacteria. It is normally found N-terminal to

. It is predicted to adopt a configuration formed mainly by β-strands.
Domain of unknown function DUF7013 (DUF7013)
Type: Domain

This is a presumed domain found in combination with different domains of phage sequences. In some proteins, at the N-terminal, followed by FN3-like domain (

) at the C-terminal. In others, flanked on both sides by an N-terminal domain (

) and a C-terminal domain (

).
Domain of unknown function DUF7014 (DUF7014)
Type: Domain

This domain is found in a group of bacterial proteins. It is often found C-terminal to

. It is predicted to adopt an all-α helical fold.
Domain of unknown function DUF7015 (DUF7015)
Type: Domain

This domain of unknown function is found at the C terminus of a group of bacterial proteins and, according to structure predictions, it may adopt a β-barrel structure. It is often associated with an Ig-like domain

.
Domain of unknown function DUF7016 (DUF7016)
Type: Domain

This entry represents an OB fold domain found in a group of uncharacterised proteins from bacteria which have a

domain at the C-terminal which also represents OB-fold domain.
Domain of unknown function (DUF7017) (DUF7017)
Type: Repeat

This entry represents a domain consisting of TPR repeats found at the N-terminal in a group of uncharacterised sequences predominantly from bacteria, which seems to be related to TOTE conflict systems as they are associated with

and

.
Protein of unknown function DUF7019 (DUF7019)
Type: Family

This is a family of uncharacterised proteins found mainly in actinomycetes. Their function is unknown. They are predicted to adopt OB fold (

) with significant similarity to Rpa.
Protein of unknown function DUF7020 (DUF7020)
Type: Family

This entry represents a family of phage proteins of unknown function. AlphaFold shows confident dimer interaction.
Domain of unknown function DUF7021 (DUF7021)
Type: Domain

This entry represents a β-barrel domain from uncharacterised bacterial proteins which is found associated with

.
Protein of unknown function DUF7022 (DUF7022)
Type: Family

This family of uncharacterised proteins is found in the T5 bacteriophage and other viruses within the family Demerecviridae. The function of this protein is unknown.
Domain of unknown function DUF7024 (DUF7024)
Type: Domain

This domain has a structure that resembles the galactose-binding domain. This domain is often associated with a sulfatase like domain (

). Suggesting that this domain may be part of an enzyme that modifies some kind of carbohydrate.
Domain of unknown function DUF7025 (DUF7025)
Type: Domain

This entry represents an SH3 barrel-like domain found in a large family of AAA proteins. The function of these proteins is uncertain.
Domain of unknown function DUF7026 (DUF7026)
Type: Domain

This entry represents a helical domain found in plant proteins. The function of these proteins is unknown.
Domain of unknown function DUF7027 (DUF7027)
Type: Domain

This is a domain of unknown function found in a group of uncharacterised proteins mainly from nematodes and arthropods. This is likely an α-helical transmembrane segment.
Domain of unknown function DUF7028 (DUF7028)
Type: Domain

This domain is found in a group of uncharacterised proteins mainly from plants. It is predicted to adopt a globular structure that has significant sequence and structural similarity to MBD domains.
Domain of unknown function DUF7029 (DUF7029)
Type: Domain

This domain is found in uncharacterised proteins mainly from fungi. It is predicted to adopt a globular structure that has some similarity to SRA domain (

). The function of this domain is unknown.
Domain of unknown function DUF7030 (DUF7030)
Type: Domain

This domain of unknown function is found N-terminal in Lysine-specific demethylase 3B (KDM3B, also known as JmjC domain-containing histone demethylation protein 2B or JHDM2B) and related proteins. KDM3B is a histone demethylase that specifically demethylates lysine at position 9 of histone H3 . This enzyme plays a central role in histone code. This domain is predicted to adopt an open β-barrel with an SH3-like topology.
Chitin synthase 4-like domain (CHS4-like_dom)
Type: Domain

This entry represents a domain found in a group of fungal proteins, including Chitin synthase 4 from Gibberella zeae (CHS4). CHS4 plays a role in the polymerisation of chitin, a structural polymer of the cell wall and septum, and shows additive effects in septum formation with the chitin synthases CHS1/2/3A/5/6/7 . This domain is predicted to adopt a globular structure with similarity to Cytochrome b5-like heme/steroid binding domain (

). However, it lacks heme coordinating residues and is probably not involved in heme binding.
Domain of unknown function DUF7032 (DUF7032)
Type: Domain

This domain is found N-terminal in a group of uncharacterised proteins mainly from plants. This domain is predicted to adopt a globular structure that folds into a four helical bundle and has a significant sequence and structural similarity to MLKL executioner domain (

).
Domain of unknown function DUF7033 (DUF7033)
Type: Domain

This uncharacterised domain is found in a group of polysaccharide deacetylases and similar proteins from bacteria.
BACOVA_00961-like (BACOVA_00961-like)
Type: Family

This family represents BACOVA_00961 from Bacteroides ovatus (

) and similar sequences mainly found in bacteroidetes. This protein shows an α/β configuration.
Glucuronosyltransferase GumK, N-terminal domain (GumK_N)
Type: Domain

Beta-1,2-glucuronosyltransferase GumK is a membrane- associated protein that is involved in the biosynthesis of xanthan. The GumK enzyme is the founding member of the glycosyltransferase family 70 of carbohydrate-active enzymes, which is composed of bacterial glycosyltransferases involved in exopolysaccharide synthesis. This protein consists of two domains; the N-terminal one is represented in this entry .
DNA polymerase alpha subunit B, OB domain (DPOA2_OB)
Type: Domain

This entry represents the OB domain of DNA polymerase alpha subunit B . B subunits of DNA polymerases stabilize the catalytic subunit, playing a role in regulation of the DNA synthesis in a cell cycle-dependent manner and act as scaffolds mediating interactions with other components of the replication machinery .
Pdc1, Ge1 domain (Pdc1_Ge1)
Type: Domain

This entry represents the Ge1 domain of Pdc1 from S.pombe. Pdc1 is known to be related to metazoan Edc4 (also known asGe-1) family, although the sequence similarity is very low. EDC4 (enhancer of mRNA-decapping protein 4) is a regulator of mRNA decapping in cytoplasmic processing bodies (P-bodies) .