SII-SWORD/CoKE huggingface dataset:
Glycerophosphocholine acyltransferase 1 (GPCAT)
Type: Family

Proteins in this family include glycerophosphocholine acyltransferase 1 (GPCAT). GPCAT homologues have been identified in most eukaryotes except chordates, but are not found in prokaryotes. GPCAT can acylate glycero-3-phosphocholine (GPC) with acyl groups from acyl-CoA. Thus it contributes to the maintenance of phosphatidylcholine (PC) homeostasis and may have specific functions in acyl editing of PC .
Protein of unknown function DUF2839 (DUF2839)
Type: Family

This bacterial family of unknown function appear to be restricted to Cyanobacteria.
Protein of unknown function DUF2840 (DUF2840)
Type: Family

This bacterial family of proteins have no known function.
Subtelomeric hrmA-associated cluster protein AFUB_079030/YDR124W-like (AFUB_079030/YDR124W-like)
Type: Family

This family represents Subtelomeric hrmA-associated cluster protein AFUB_079030 from Aspergillus fumigatus and similar fungal proteins. AFUB_079030 is part of the subtelomeric hrmA-associated cluster (HAC) containing genes that alter the hyphal surface (such as reduced total chitin or increased beta-glucan exposure) and perturb inter-hyphal interactions within the developing biofilms, resulting in a loss of vertically aligned polarised growing filaments . This group also includes yeast protein YDR124W. Null mutant showed severe fragmentation of mitochondria and its expression is strongly induced by alpha factor. Some members of this family may have role in maintenance of mitochondrial morphology .
Protein of unknown function DUF2842 (DUF2842)
Type: Family

This bacterial family of proteins have no known function.
Kdo hydroxylase (Kdo_hydroxlase)
Type: Family

This is a family of 3-deoxy-D-manno-oct-2-ulosonic acid 3-hydroxylases, which catalyse the conversion of 3-deoxy-D-manno-oct-2-ulosonic acid (Kdo) to D-glycero-D-talo-oct-2-ulosonic acid (Ko). It contains a potential iron-binding motif, HXDX(n)H (n>40). Hydroxylation activity is iron-dependent .
Protein of unknown function DUF2844 (DUF2844)
Type: Family

This bacterial family of proteins has no known function.
Protein of unknown function DUF2845 (DUF2845)
Type: Family

This bacterial family of proteins has no known function.
Protein of unknown function DUF2848 (DUF2848)
Type: Family

This bacterial family of proteins has no known function.
Protein of unknown function DUF2849 (DUF2849)
Type: Family

This bacterial family of proteins has no known function.
Protein of unknown function DUF2850 (DUF2850)
Type: Family

This family of proteins with unknown function appear to be restricted to Vibrionaceae.
Protein of unknown function DUF2851 (DUF2851)
Type: Family

This bacterial family of proteins has no known function.
Protein of unknown function DUF2852 (DUF2852)
Type: Family

This bacterial family of proteins has no known function.
Protein of unknown function DUF2853 (DUF2853)
Type: Family

This bacterial family of proteins has no known function.
Protein of unknown function DUF2854 (DUF2854)
Type: Family

This family of proteins has no known function.
Protein of unknown function DUF2855 (DUF2855)
Type: Family

This family of proteins has no known function.
Protein of unknown function DUF2610 (DUF2610)
Type: Family

This family of proteins is functionally uncharacterised. They are predicted to contain a ribbon-helix-helix fold, so may function as DNA-binding proteins.
ATP synthase subunit K (ATP19)
Type: Family

This entry represents ATP synthase subunit K (Atp19) from fungi. Atp19 is the subunit k of the mitochondrial F1F0 ATP synthase, which produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain . In the yeast Pichia angusta this is known as ATP synthase subunit L .
Protein of unknown function DUF2721 (DUF2721)
Type: Family

This family is conserved in bacteria. The function is not known.
Protein O-mannosyl-transferase TMEM260-like (TMEM260-like)
Type: Family

This family includes human Protein O-mannosyl-transferase TMEM260 and similar sequences from bacteria and eukaryota. TMEM260 transfers mannosyl residues to the hydroxyl group of serine or threonine residues of proteins .
Small nuclear RNA activating complex subunit 2 (SNAPC2)
Type: Family

The SNAPc complex allows the transcription of human small nuclear RNA genes to occur by recognition of the proximal sequence element, the TATA box . SNAPC2 functions both to specifically recognise the proximal sequence element present in the core promoters of human snRNA genes and to stimulate TBP recognition of the neighbouring TATA box present in human U6 snRNA promoters .
Dispersed gene family protein 1, domain 5 (Dispersed_gene_fam_prot1_dom5)
Type: Domain

Dispersed gene family protein 1 (DGF-1) of Trypanosoma cruzi is one of the most abundant proteins in T. cruzi genome . It seems to have a preferential expression in amastigotes (intracellular replicative forms that develop in the mammalian host) . The function of this protein is not yet clear, however, it is likely to play a role in cell-to-cell interactions or signal transduction . This entry represents domain 5 on this protein, found upstream the C-terminal domain. It may have adopt a β-sandwich fold.
Protein of unknown function DUF2612 (DUF2612)
Type: Family

This is a phage protein family expressed from a range of Proteobacteria species. The function is not known.
Protein of unknown function DUF2750 (DUF2750)
Type: Family

This family is conserved in Proteobacteria. The function is not known.
Transcription regulator, HycA (Tscrpt_reg_HycA)
Type: Family

This family is conserved in Proteobacteria. It is likely to be the transcriptional repressor molecule for the hyc and hyp operons, which express, amongst others, the protein HycA. This protein may be harnessed for the reduction of technetium oxide, an unwelcome product of radio-nucleotide bioaccumulation. HycA produces formate hydrogenlyase, one of the key proteins necessary for metal compound reduction .
Baculovirus, protein E26 (Baculovirus_E26)
Type: Family

DA26 (E26) is a multifunctional protein. One form of E26 associates with viral DNA or DNA binding proteins, while a second form associates with intracellular membranes . It functions to sort occlusion-derived virus envelope proteins to the inner nuclear membrane .
Trans-sialidase, conserved site (Trans-sialidase_CS)
Type: Conserved_site

This is a highly conserved region, of about 50aa, that is the very C terminus of a number of more diverse proteins from Trypanosoma cruzi. All members of the family are annotated putatively as being trans-sialidase but this appears to be a diverse group.
Sporulated oocyst TA4 antigen (Surface_antigen)
Type: Family

This family of proteins is a Eukaryotic family of surface antigens. One of the better characterised members of the family is the sporulated oocyst TA4 antigen from Eimeria tenella. The TA4 gene encodes a single polypeptide of 25kDa which contains a 17 and a 8kDa polypeptide .
Recombination, repair and ssDNA binding protein UvsY (UvsY)
Type: Family

UvsY protein enhances the rate of single-stranded-DNA-dependent ATP hydrolysis by UvsX protein. The enhancement of ATP hydrolysis by UvsY protein is shown to result from the ability of UvsY protein to increase the affinity of UvsX protein for single-stranded DNA .
Protein of unknown function DUF2861 (DUF2861)
Type: Family

This bacterial family of proteins has no known function.
Cytochrome b6f, subunit Tsr0524-like (Tsr0524-like)
Type: Family

This family of proteins is predominantly found in cyanobacteria and red algae, including Uncharacterized protein ORF65 from Porphyra purpurea and Tsr0524 from Thermosynechococcus vestitus. Tsr0524 (also known as PetP) is a component of the cyanobacterial cytochrome b6f that may play an essential role in the regulation of photosynthetic electron transport. It shows an SH3 domain fold with five antiparallel β-sheets .
Protein of unknown function DUF2863 (DUF2863)
Type: Family

This bacterial family of proteins have no known function.
Protein of unknown function DUF2865 (DUF2865)
Type: Family

This bacterial family of proteins has no known function.
Protein of unknown function DUF2866 (DUF2866)
Type: Family

This bacterial family of proteins have no known function.
Protein of unknown function DUF2867 (DUF2867)
Type: Family

This family contains uncharacterised proteins, including the single-pass membrane protein YbjT from
Escherichia coli
which has an N-terminal NAD(P)-binding domain.
Protein of unknown function DUF2868 (DUF2868)
Type: Family

Some members in this family of proteins with unknown function are annotated as putative membrane proteins. However, this cannot be confirmed.
YlqD protein (YlqD)
Type: Family

The structure of a representative of this family has been solved and found to form a tetrameric structure of prefoldin-like architecture with the β-barrel core and helical coiled coil tentacles. This suggests that this family may act as molecular chaperones.
Cilia- and flagella-associated protein 298 (CFAP298)
Type: Family

This entry includes a group of cilia- and flagella-associated protein, including Kur from zebrafish and C21orf59 from humans. Kur has been shown to play a dual role in cilia motility and polarization .

Primary ciliary dyskinesia (PCD) is caused when defects of motile cilia lead to chronic airway infections, male infertility, and situs abnormalities. Mutations in the C21orf59 gene cause ciliary dyskinesia, primary, 26 (CILD26) .
Protein of unknown function DUF2871 (DUF2871)
Type: Family

This family of proteins has no known function.
Integrating conjugative element protein, PFL4695 (Integr_conj_element_PFL4695)
Type: Family

This model describes a protein family exemplified by PFL_4695 of Pseudomonas fluorescens Pf-5. Full-length proteins in this family show some architectural variety, but this model represents a conserved domain. Most or all member proteins belong to laterally transferred chromosomal islands called integrative conjugative elements, or ICE.
Domain of unknown functionDUF2779 (DUF2779)
Type: Domain

This domain is conserved in bacteria. The function is not known.
Protein of unknown function DUF2780, VcgC/VcgE (DUF2780_VcgC/VcgE)
Type: Family

This is a bacterial family of uncharacterised proteins.
Uncharacterised protein family, inner membrane, YbhQ (Uncharacterised_YbhQ)
Type: Family

This family is conserved in Proteobacteria. The function is not known but most members are annotated as being inner membrane protein YbhQ.
Adenovirus L4-33K/L4-22K (Adeno_L4-33K/L4-22K)
Type: Family

Adenoviruses express up to 20 distinct mRNAs from five major late transcription unit (MLTU) regions, L1 to L5. The L4 region expresses L4-33K and a related protein, L4-22K .
Protein of unknown function DUF2880 (DUF2880)
Type: Family

This bacterial family of proteins has no known function.
Protein of unknown function DUF2878 (DUF2878)
Type: Family

This bacterial family of proteins has no known function. Some members annotate the proteins as the permease component of a Mn2+/Zn2+ transport system however this cannot be confirmed.
Protein of unknown function DUF2884 (DUF2884)
Type: Family

Some members in this bacterial family of proteins are annotated as YggN which currently has no known function.
Group 4 capsule polysaccharide formation lipoprotein GfcB (GfcB)
Type: Family

This family includes lipoprotein GfcB (YmcC), involved in group 4 capsule polysaccharide formation .
Inner membrane protein YgaP-like, transmembrane domain (YgaP-like_TM)
Type: Domain

This entry represents a domain found in proteins from bacteria and archaea, including Inner membrane protein YgaP from Escherichia coli, a membrane protein with a rhodanese domain (

) that may have sulfurtransferase activity. YgaP adopts a dimeric assembly. This entry represents the transmembrane domain. It consist of two slightly tilted α-helices
.
Plant viral coat protein nucleocapsid (Nucleocap_ssRNA)
Type: Family

This family of nucleocapsid proteins is from ssRNA negative-strand viruses of plant origin.
Rev protein of equine infectious anaemia virus (EIAV_Rev)
Type: Family

The sequence of this family is highly conserved and carries a nuclear export signal from residues 31-55, and RNA binding/nuclear localisation signals of RRDR at residue 76 and KRRRK at residue 159. Rev is an essential regulatory protein required for nucleocytoplasmic transport of incompletely spliced viral mRNAs that encode structural proteins. Rev has been shown to down-regulate the expression of viral late genes and alter sensitivity to Gag-specific cytotoxic-T-lymphocytes (CTL). Equine infectious anaemia virus (EIAV) exhibits a high rate of genetic variation in vivo, and results in a clinically variable disease in infected horses.
Protein of unknown function DUF2889 (DUF2889)
Type: Family

This bacterial family of proteins has no known function.
Protein of unknown function DUF2909 (DUF2909)
Type: Family

This is a family of proteins conserved in Proteobacteria of unknown function.
Protein of unknown function DUF2911 (DUF2911)
Type: Family

This bacterial family of proteins has no known function.
Glycolipid exporter Gap/Sap (Gap/Sap)
Type: Family

This entry includes glycolipid exporters form bacteria and archaea, including peptidoglycolipid exporter Gap from Mycobacterium smegmatis and Sulfolipid-1 exporter Sap from Mycobacterium tuberculosis. Sap is required for the transport across the inner membrane of sulfolipid-1 (SL-1), which is a major cell wall lipid of pathogenic mycobacteria . Gap is required for the transport of peptidoglycolipids (GPLs) to the cell surface .
Protein of unknown function DUF2913 (DUF2913)
Type: Family

This family of proteins with unknown function appear to be restricted to Gammaproteobacteria.
Protein of unknown function DUF2917 (DUF2917)
Type: Family

This bacterial family of proteins appears to be restricted to Proteobacteria.
Protein of unknown function DUF2919 (DUF2919)
Type: Family

This entry represents a group of bacterial proteins, including the inner membrane protein YfeZ from E. coli. The function of YfeZ is not clear.
SWEET-like domain (DUF2921)
Type: Domain

This entry describes a domain of unknown function, which could adopt a similar fold to the SWEET-like (TM helices) domain. It was found in transmembrane E3 ubiquitin-proteins and members of the DSC E3 ubiquitin ligase complex. It is predominant in fungi and plants, including the FLY1/2 proteins from Arabidopsis thaliana, the DSC complex protein from Schizosaccharomyces pombe, and TUL1 from Saccharomyces cerevisiae. This domain hasn't been functionally characterised yet but it is formed by seven α-helices .

The DSC E3 ubiquitin ligase complex, located in the Golgi and endosomes, identifies and ubiquitinates orphaned proteins with short transmembrane domains for degradation, maintaining membrane protein homeostasis. It includes subunits like Tul1 (E3 ligase) and Dsc2 (substrate recognition) . The Transmembrane E3 ubiquitin-protein ligase FLY1, a plant homologue of Tul1, regulates pectin methyl esterification in seed mucilage, affecting cell wall properties and cell adhesion in Arabidopsis thaliana .
Protein of unknown function DUF2905 (DUF2905)
Type: Family

This is a family of bacterial proteins conserved of unknown function.
Protein of unknown function DUF2922 (DUF2922)
Type: Family

This bacterial family of proteins has no known function.
Protein of unknown function DUF2924 (DUF2924)
Type: Family

This family of proteins has not been functionally characterised.
Protein of unknown function DUF2927 (DUF2927)
Type: Family

This family is conserved in Proteobacteria. Several members are described as being putative lipoproteins, but otherwise the function is not known.
Protein of unknown function DUF2929 (DUF2929)
Type: Family

This family of proteins with unknown function appears occur predominantly in Firmicutes.
Cofactor assembly of complex C subunit B, CCB2/CCB4 (CCB2/CCB4)
Type: Family

Cofactor maturation pathways such as the CCB system (system IV) for cytochrome c-heme attachment are conserved in all organisms performing oxygenic photosynthesis . The CCB system consists of four proteins: CCB1-4. CCB2 and CCB4 are paralogues derived from a unique cyanobacterial ancestor . Orthologues are conserved in higher plants .
Protein of unknown function DUF2931 (DUF2931)
Type: Family

Some members in this family of proteins are annotated as lipoproteins however this cannot be confirmed. Currently, there is no known function.
Protein of unknown function DUF2934 (DUF2934)
Type: Family

This bacterial family of proteins has no known function.
Spore coat protein CotB-like (CotB-like)
Type: Family

This family of proteins, previously known as DUF2935, includes Spore coat protein CotB from Clostridioides difficile and similar sequences mainly found in firmicutes. CotB contributes to the formation of thick-exosporium spores .
Protein of unknown function DUF2938 (DUF2938)
Type: Family

This bacterial and archaeal family of proteins has no known function. Some members are thought to be membrane proteins, however this has not been confirmed.
Protein of unknown function DUF2939 (DUF2939)
Type: Family

This bacterial family of proteins has no known function.
Hypervirulence associated protein, TUDOR domain (Hva1_TUDOR)
Type: Domain

Proteins containing this domain include HVA1 (hypervirulence-associated protein 1) from Cryptococcus neoformans (

), whose absence is associated with a hypervirulent phenotype in mice. Metabolomics analysis suggests that when HVA1 is absent there is a block in the citric acid cycle, while structural analysis of the Hva1 protein suggests a potential interaction with NADPH. Its structural architecture bears similarity with Tudor domains. Hva1 may play a role in primary metabolism .
Protein of unknown function DUF2944 (DUF2944)
Type: Family

This family of proteins with unknown function appear to be restricted to Proteobacteria.
Protein of unknown function DUF2946 (DUF2946)
Type: Family

This family of proteins has no known function.
Protein of unknown function DUF2947 (DUF2947)
Type: Family

This family of proteins with unknown function appears to be restricted to Gammaproteobacteria.
Protein of unknown function DUF2948 (DUF2948)
Type: Family

This family of proteins with unknown function appear to be restricted to Proteobacteria.
Protein of unknown function DUF2949 (DUF2949)
Type: Family

This family of proteins with unknown function appear to be restricted to Cyanobacteria.
Protein of unknown function DUF2951 (DUF2951)
Type: Family

This family of proteins has no known function. It has a highly conserved sequence.
Protein of unknown function DUF2953 (DUF2953)
Type: Family

This family of proteins has no known function.
Protein of unknown function DUF2956 (DUF2956)
Type: Family

This family of proteins with unknown function appears to be restricted to Gammaproteobacteria.
Protein of unknown function DUF2957 (DUF2957)
Type: Family

Some members annotate the proteins to be putative lipoproteins however this cannot be confirmed. Currently no function is known for this family of proteins.
Protein of unknown function DUF2958 (DUF2958)
Type: Family

Some members are annotated as lipoproteins however this cannot be confirmed. This family of proteins has no known function.
Protein of unknown function DUF2959 (DUF2959)
Type: Family

DUF2959 is a family of uncharacterised proteins.
Protein of unknown function DUF2960 (DUF2960)
Type: Family

This family of proteins with unknown function appears to be restricted to Gammaproteobacteria.
Protein of unknown function DUF2970 (DUF2970)
Type: Family

This short family is conserved in Proteobacteria. The function is not known.
Protein of unknown function DUF2961 (DUF2961)
Type: Family

This family of proteins has no known function.
Translation machinery-associated protein 16 (Tma16)
Type: Family

Proteins in this family localise to the nucleus . Their function is not clear.
Protein of unknown function DUF2964 (DUF2964)
Type: Family

This family of proteins with unknown function appears to be restricted to Proteobacteria.
Domiain of unknown function DUF2963 (DUF2963)
Type: Domain

This domain of unknown function is found mainly in Mollicutes.
Protein of unknown function DUF2967 (DUF2967)
Type: Family

This family of proteins with unknown function appears to be restricted to Drosophila.
Protein of unknown function DUF2968 (DUF2968)
Type: Family

This family of proteins has no known function.
Protein of unknown function DUF2969 (DUF2969)
Type: Family

This family of proteins with unknown function appears to be restricted to Lactobacillales.
Protein of unknown function DUF2971 (DUF2971)
Type: Family

This bacterial family of proteins has no known function.
Protein of unknown function DUF2972 (DUF2972)
Type: Family

Some members in this family of proteins with unknown function are annotated as sugar transferase proteins, however this cannot be confirmed.
Protein of unknown function DUF2975 (DUF2975)
Type: Family

This family of bacterial proteins have no known function. These proteins are likely to be integral membrane proteins. The proteins contain a highly conserved glutamic acid close to their C terminus.
Bacteriophage Syn9, Gp224 (Phage_Syn9_Gp224)
Type: Family

This entry is represented by Bacteriophage Syn9, Gp224. The characteristics of the protein distribution suggest prophage matches in addition to the phage matches.

Some members in this family of proteins are annotated as membrane proteins however this cannot be confirmed. Currently they have no known function.
Integrating conjugative element protein PFL4702 (Integr_conj_element_PFL4702)
Type: Family

Members of this protein family are found occasionally on plasmids such as the Pseudomonas putida TOL plasmid pWWO_p085. Usually, however, they are found on the bacterial main chromosome in a region flanked by markers of conjugative transfer and/or transposition.
Protein of unknown function DUF2782 (DUF2782)
Type: Family

This is a bacterial family of proteins whose function is unknown.
Protein of unknown function DUF2977 (DUF2977)
Type: Family

This entry includes Bacteriophage 96, Orf38. The characteristics of the protein distribution suggest prophage matches in addition to the phage matches.
Protein of unknown function DUF2812 (DUF2812)
Type: Family

This is a bacterial family of uncharacterised proteins, however some members of this family are annotated as membrane proteins.
Thoeris anti-defense 2-like domain (Tad2-like_dom)
Type: Domain

This entry represents Thoeris anti-defense 2 from Bacillus phage SP01 (Tad2) and similar sequences from tailed bacteriophages and bacterial prophagues. Tad2 is an anti-defence protein that counteracts the host Thoeris antiviral defence system. It sequesters the immune signalling molecules produced by Thoeris TIR-domain proteins in response to phage infection .
Protein of unknown function DUF2834 (DUF2834)
Type: Family

The function of DUF2834 is not clear.
Protein of unknown function DUF2835 (DUF2835)
Type: Family

This is a bacterial family of uncharacterised proteins. One member of this family (

) is annotated as the A subunit of Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV).
Protein of unknown function DUF2857 (DUF2857)
Type: Family

This is a bacterial family of uncharacterised proteins.
Protein of unknown function DUF2891 (DUF2891)
Type: Family

This is a bacterial family of uncharacterised proteins.
Protein of unknown function DUF2981 (DUF2981)
Type: Family

This eukaryotic family of proteins has no known function.
Protein of unknown function DUF2982 (DUF2982)
Type: Family

This family of proteins with unknown function appears to be restricted to Gammaproteobacteria.
Type VII secretion system protein EccE (T7SS_EccE)
Type: Family

This entry represents the transmembrane protein EccE and similar proteins found in Actinobacteria, which are part of type VII secretion system (T7SS) .
Protein of unknown function DUF2985 (DUF2985)
Type: Family

This eukaryotic family of proteins has no known function.
Protein of unknown function DUF2987 (DUF2987)
Type: Family

This family of proteins with unknown function appears to be restricted to Gammaproteobacteria.