SII-SWORD/CoKE huggingface dataset:
Protein of unknown function DUF3896 (DUF3896)
Type: Family

This family of bacterial proteins is functionally uncharacterised.
Protein of unknown function DUF3895 (DUF3895)
Type: Family

This family of bacterial proteins is functionally uncharacterised. There are two completely conserved residues (Y and L) that may be functionally important.
pPIWI_RE, RNaseH domain (RNaseH_pPIWI_RE)
Type: Domain

This entry represents the RNaseH domain of the pPIWI_RE PIWI/Argonaute module. pPIWI_RE is found in a conserved three-gene island that also contains a DinG-type helicase and an REase nuclease. This three gene island is predicted to form a conflict system which targets R-loop formation of invasive plasmids during plasmid replication .
Protein of unknown function DUF3892 (DUF3892)
Type: Family

DUF3892 is related to the truncated RNaseH fold-containing ribosome hibernation factors. Predicted to function as a possible conflict effector domain at the ribosome, based on comparable genome contextual associations with DUF2188, including repeated association with nucleotide-activated effector conflict systems .
Protein of unknown function DUF3906 (DUF3906)
Type: Family

This family of bacterial proteins is functionally uncharacterised. Family members are approximately 70 amino acids in length. There is a conserved EKK sequence motif.
Protein of unknown function DUF3905 (DUF3905)
Type: Family

This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 110 amino acids in length.
Protein of unknown function DUF3903 (DUF3903)
Type: Family

This family is functionally uncharacterised. Proteins in this family are found in bacteria, and they are approximately 40 amino acids in length.
Protein of unknown function DUF3902 (DUF3902)
Type: Family

This family of proteins found in firmicutes is functionally uncharacterised. Proteins in this family are approximately 170 amino acids in length. There is a conserved LGI sequence motif.
Domain of unknown function DUF3972 (DUF3972)
Type: Domain

This entry represents a domain whose function is not currently known.
Domain of unknown function DUF3973 (DUF3973)
Type: Domain

This presumed domain, approximately 40 amino acids in length, is functionally uncharacterised. It contains a conserved YCI sequence motif.
Transcriptional regulatory protein SenN/SenS (SenN/SenS)
Type: Family

This family of bacterial proteins includes the transcriptional regulatory proteins senN and senS, which regulate the expression of extracellular-protein genes of Bacillus subtilis .
Domain of unknown function DUF3974 (DUF3974)
Type: Domain

This presumed domain, approximately 130 amino acids in length, is functionally uncharacterised.
Protein of unknown function DUF3900 (DUF3900)
Type: Family

This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 360 amino acids in length.
Domain of unknown function DUF3899 (DUF3899)
Type: Domain

This domain is found in uncharacterised bacterial sequences, some described as possible tryptophanyl-tRNA synthetases.
Domain of unknown function DUF3976 (DUF3976)
Type: Domain

This presumed domain, approximately 40 amino acids in length, is functionally uncharacterised.
Protein of unknown function DUF3977 (DUF3977)
Type: Family

This family of proteins is functionally uncharacterised.
Protein of unknown function DUF3978 (DUF3978)
Type: Family

This family of proteins is functionally uncharacterised.
Protein of unknown function DUF3963 (DUF3963)
Type: Family

Proteins in this family are from Bacilli bacteria and arefunctionally uncharacterised. They are typically between 42 and 85 amino acids in length and contain a conserved DIQKW sequence motif.
Domain of unknown function DUF3898 (DUF3898)
Type: Domain

This presumed domain is functionally uncharacterised. It is found in bacterial sequences. There are two conserved sequence motifs: DFG and FEKG.
Protein of unknown function DUF3907 (DUF3907)
Type: Family

This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 160 amino acids in length. There is a conserved AYTG sequence motif.
Protein of unknown function DUF3958 (DUF3958)
Type: Family

This family of proteins is functionally uncharacterised. Proteins in this family are approximately 120 amino acids in length and contain two conserved sequence motifs: RLF and TWH.
Protein of unknown function DUF3975 (DUF3975)
Type: Family

This family of proteins is functionally uncharacterised.
Domain of unknown function DUF3955 (DUF3955)
Type: Domain

This entry represents a domain found in a family of bacterial and fungal proteins that are functionally uncharacterised. It contains two completely conserved residues (G and E) that may be functionally important.
Protein of unknown function DUF3954 (DUF3954)
Type: Family

This family of proteins has not yet been functionally characterised.
Protein of unknown function DUF3953 (DUF3953)
Type: Family

This family of proteins has not yet been functionally characterised.
Domain of unknown function DUF3952 (DUF3952)
Type: Domain

This presumed domain is functionally uncharacterised, found in some species of Bacillus. It is approximately 110 amino acids in length and contains a conserved VMSAS sequence motif.
Protein of unknown function DUF3908 (DUF3908)
Type: Family

This family of proteins is functionally uncharacterised. There is a single completely conserved residue Y that may be functionally important.
Protein of unknown function DUF3910 (DUF3910)
Type: Family

This family of proteins is functionally uncharacterised.
Protein of unknown function DUF3911 (DUF3911)
Type: Family

This family of proteins is functionally uncharacterised.
Protein of unknown function DUF3912 (DUF3912)
Type: Family

This family of proteins is functionally uncharacterised.
Protein of unknown function DUF3913 (DUF3913)
Type: Family

This family of proteins is functionally uncharacterised.
Protein of unknown function DUF3914 (DUF3914)
Type: Family

This family of proteins is functionally uncharacterised. There are two conserved sequence motifs: KFDIR and DLW.
Protein of unknown function DUF3915 (DUF3915)
Type: Family

This family of proteins is functionally uncharacterised.
Protein of unknown function DUF3917 (DUF3917)
Type: Family

This family of proteins is functionally uncharacterised.
Protein of unknown function DUF3951 (DUF3951)
Type: Family

This family of proteins is functionally uncharacterised. Proteins in this family are typically between 56 and 71 amino acids in length and contain a conserved YTP sequence motif.
Protein of unknown function DUF3918 (DUF3918)
Type: Family

This family of proteins is functionally uncharacterised. There are two completely conserved residues (G and R) that may be functionally important.
Domain of unknown function DUF3950 (DUF3950)
Type: Domain

This presumed domain is functionally uncharacterised. It is approximately 30 amino acids in length and contains a conserved NFS sequence motif.
Protein of unknown function DUF3919 (DUF3919)
Type: Family

This family of proteins is functionally uncharacterised. There is a conserved YLNG sequence motif.
Protein of unknown function DUF3949 (DUF3949)
Type: Family

This family of proteins is functionally uncharacterised.
Protein of unknown function DUF3920 (DUF3920)
Type: Family

This family of proteins is functionally uncharacterised.
Protein of unknown function DUF3948 (DUF3948)
Type: Family

This family of proteins is functionally uncharacterised.
Protein of unknown function DUF3922 (DUF3922)
Type: Family

This family of proteins is functionally uncharacterised.
Protein of unknown function DUF3921 (DUF3921)
Type: Family

This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 60 amino acids in length.
External database links
Protein of unknown function DUF3923 (DUF3923)
Type: Family

This family of proteins is functionally uncharacterised.
Protein of unknown function DUF3924 (DUF3924)
Type: Family

This family of proteins is functionally uncharacterised.
Protein of unknown function DUF3947 (DUF3947)
Type: Family

This family of proteins has not been functionally characterised
Protein of unknown function DUF3984 (DUF3984)
Type: Family

This family of proteins is currently functionally uncharacterised.
Protein of unknown function DUF3983 (DUF3983)
Type: Family

This family of proteins is functionally uncharacterised. Proteins in this family contain a conserved AWRN sequence motif.
Domain of unknown function DUF3981 (DUF3981)
Type: Domain

This presumed domain, approximately 110 amino acids in length, is functionally uncharacterised.
Domain of unknown function DUF3980 (DUF3980)
Type: Domain

This presumed domain, approximately 90 amino acids in length, is functionally uncharacterised.
Protein of unknown function DUF3979 (DUF3979)
Type: Family

This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 120 amino acids in length.
Domain of unknown function DUF3960 (DUF3960)
Type: Domain

This presumed domain, typically between 72 and 89 amino acids in length, is functionally uncharacterised.
Protein of unknown function DUF3986 (DUF3986)
Type: Family

This family of proteins is functionally uncharacterised.
Protein of unknown function DUF3987) (DUF3987)
Type: Family

This entry represents a family of uncharacterised proteins that was originally found by clustering human gut metagenomic sequences .
Fimbrillin-like 1 (Mfa-like_1)
Type: Family

A family of putative fimbrillin proteins found by clustering human gut metagenomic sequences . Analysis of structural comparisons shows this family to be part of the FimbA (CL0450) superfamily of adhesin components or fimbrillins.
Conjugative transposon protein TraL (TraL_transposon)
Type: Family

This entry represents a family that contains conjugal transfer protein TraL .
Protein of unknown function DUF3990 (DUF3990)
Type: Family

This entry represents a family of uncharacterised proteins that was originally found by clustering human gut metagenomic sequences .
Domain of unknown function DUF3967 (DUF3967)
Type: Domain

This presumed domain is functionally uncharacterised.
Protein of unknown function DUF3985 (DUF3985)
Type: Family

This family of proteins is functionally uncharacterised.
Domain of unknown function DUF3991 (DUF3991)
Type: Domain

The function is this domain is not known. It is often associated with a Toprim (topoisomerase-primase) domain (

).
Endospore appendages core (Ena_core)
Type: Domain

The surface of Bacillus and Clostridium endospores is decorated with long filamentous endospores appendages that resemble pili from Gram-negative and Gram-positive bacteria. They show two morphologies, the main or Staggered-type (S-Ena) which accounts for 90% of the fibres, and the Ladder-like (L-Ena) which is smaller and less abundant. They are a novel class of Gram-positive pili, consisting in single domain subunits with a jellyroll topology comprised by two juxtaposed β-sheets. This entry represents the S-Ena core. Disulfide bonding through the N-terminal connector peptide that precedes this domain stabilizes longitudinally the fibres, bridging the helical turns. This results in flexible pili, highly resistant to environmental harsh such as heat, drought, and chemical damage .
Protein of unknown function DUF3993 (DUF3993)
Type: Family

This family of proteins is functionally uncharacterised.
Domain of unknown function DUF3994 (DUF3994)
Type: Domain

This domain is found at the C-terminal of a group of proteins from Bacillus that have

at the N-terminal. Members are functionally uncharacterised.
Protein of unknown function DUF3995 (DUF3995)
Type: Family

This family of proteins is functionally uncharacterised. Proteins in this family are typically between 138 and 149 amino acids in length and contain two completely conserved residues (W and P) that may be functionally important.
Protein of unknown function DUF3997 (DUF3997)
Type: Family

This family of proteins is functionally uncharacterised.
Protein of unknown function DUF3999 (DUF3999)
Type: Family

This family of proteins is functionally uncharacterised. Proteins in this family are typically between 440 and 470 amino acids in length and contain a single completely conserved residue D that may be functionally important.
Diedel (Diedel)
Type: Family

Diedel (die) was identified as an insect immune response protein. It is up-regulated after a septic injury and may act as a negative regulator of the JAK/STAT signalling pathway . Its homologues can be found in Drosophila and Acyrtosiphon pisum. Interestingly, the orthologues of the die gene are present in the genome of insect DNA viruses of the Baculoviridae and Ascoviridae families. The viral homologues suppress the immune deficiency (IMD) pathway in Drosophila .
Protein of unknown function DUF4003 (DUF4003)
Type: Family

This family of proteins is functionally uncharacterised.
Protein of unknown function DUF4004 (DUF4004)
Type: Family

This family of proteins is functionally uncharacterised.
Domain of unknown function DUF4005 (DUF4005)
Type: Domain

This domain is found towards the C terminus of a number of plant IQ domain-containing proteins. These proteins may be involved in cooperative interactions with calmodulins or calmodulin-like proteins, and may associate with nucleic acids and regulate gene expression at the transcriptional or post-transcriptional level.
Protein of unknown function DUF4006 (DUF4006)
Type: Family

This family of proteins is functionally uncharacterised.
Coiled-coil domain-containing protein 174-like (CCDC174-like)
Type: Family

This entry represents CCDC174 and related proteins from animals, fungi and plants.

CCDC174 is a ubiquitous protein which is restricted to the cell nucleus and co-localises with EIF4A3 . Mutations in this gene have been linked to a syndrome characterised by hypotonia (low muscle tone) and psychomotor developmental delay .
Protein of unknown function DUF4079 (DUF4079)
Type: Family

This is an uncharacterised family of proteins.
Protein of unknown function DUF3937 (DUF3937)
Type: Family

This family of proteins is functionally uncharacterised.
Cleavage and polyadenylation specificity factor 2, C-terminal (Cpsf2_C)
Type: Domain

This domain lies at the C terminus of many fungal and plant cleavage and polyadenylation specificity factor subunit 2 proteins. The exact function of the domain is not known, but is likely to function as a binding domain for the protein within the overall CPSF complex .
Protein of unknown function DUF3938 (DUF3938)
Type: Family

This family of proteins is functionally uncharacterised.
Protein of unknown function DUF3939 (DUF3939)
Type: Family

This family of proteins is functionally uncharacterised.
Fur-regulated basic protein A (Fur_reg_FbpA)
Type: Family

This family of proteins is regulated by the ferric uptake regulator protein Fur . This family does not regulate the lutABC operon encoding iron sulfur-containing enzymes necessary for growth on lactate .
Protein of unknown function DUF3909 (DUF3909)
Type: Family

This family of proteins is functionally uncharacterised.
Protein of unknown function DUF3942 (DUF3942)
Type: Family

This family of proteins is functionally uncharacterised.
Protein of unknown function DUF3916 (DUF3916)
Type: Family

This family of proteins is functionally uncharacterised. There is a single completely conserved residue S that may be functionally important.
Protein of unknown function DUF3926 (DUF3926)
Type: Family

This family of proteins is functionally uncharacterised. There is a single completely conserved residue P that may be functionally important.
Protein of unknown function DUF3941 (DUF3941)
Type: Family

This family is functionally uncharacterised. Proteins in this family are mainly found in Bacillus and contain a conserved YSK sequence motif.
Protein of unknown function DUF3931 (DUF3931)
Type: Family

This family of proteins is functionally uncharacterised.
Domain of unknown function DUF3943 (DUF3943)
Type: Domain

This presumed domain is functionally uncharacterised. It is approximately 110 amino acids in length.
Protein of unknown function DUF3959 (DUF3959)
Type: Family

This family of proteins is functionally uncharacterised.
Domain of unknown function DUF3961 (DUF3961)
Type: Domain

This presumed domain is functionally uncharacterised. It is approximately 40 amino acids in length.
Protein of unknown function DUF3964 (DUF3964)
Type: Family

This family of proteins is functionally uncharacterised. There are two conserved sequence motifs: FYF and AFW.
Protein of unknown function DUF3969 (DUF3969)
Type: Family

This family of proteins is functionally uncharacterised.
Protein of unknown function DUF3966 (DUF3966)
Type: Family

This family of proteins is functionally uncharacterised.
pPIWI_RE module, N-terminal domain (pPIWI_RE_X)
Type: Domain

This entry represents a domain N-terminal to the pPIWI_RE domain module. PIWI/Argonaute modules are typically N-terminally fused to the PTND1 and PTND2 domains , pPIWI_RE_X may represent an ancestral version of these domains or represent a N-terminal innovation predating the emergence of PTND1 and PTND2 .
SDE2/SF3A3, SAP domain (SDE2/SF3A3_SAP)
Type: Domain

This is the SAP domain found at the C-terminal of SDE2 and in the middle region of splicing factor 3A subunit 3 (SF3A, also known as noisette) . SDE2 is both an RNA-binding protein and also a trans-acting adaptor protein that functions to regulate RNA splicing and ribosome biogenesis. SF3A is involved in pre-mRNA splicing as a component of pre-catalytic spliceosome 'B' complexes .
Domain of unknown function DUF3965 (DUF3965)
Type: Domain

This presumed domain is functionally uncharacterised.
Protein of unknown function DUF3970 (DUF3970)
Type: Family

This family of proteins is functionally uncharacterised.
Protein of unknown function DUF4018 (DUF4018)
Type: Family

This family of proteins is functionally uncharacterised.
Protein of unknown function DUF4017 (DUF4017)
Type: Family

This family of proteins is functionally uncharacterised.
Protein of unknown function DUF4019 (DUF4019)
Type: Family

This family of proteins is functionally uncharacterised. There is a single completely conserved residue E that may be functionally important.
Glycosyl hydrolase family 66 (Glyco_hydro_66)
Type: Family

This family is a set of glycosyl hydrolase enzymes including cycloisomaltooligosaccharide glucanotransferase ([ec:2.4.1.-]) and dextranase (

) activities.
Domain of unknown function DUF4020 (DUF4020)
Type: Domain

This presumed domain is functionally uncharacterised. This domain is found in bacteria, and is typically between 176 and 195 amino acids in length.
Protein of unknown function DUF4021 (DUF4021)
Type: Family

This family of proteins is functionally uncharacterised. There is a conserved YGM sequence motif.
Protein of unknown function DUF4022 (DUF4022)
Type: Family

This family of proteins is functionally uncharacterised.
Protein of unknown function DUF4014 (DUF4014)
Type: Family

This is a bacterial and viral family of uncharacterised proteins.
Protein of unknown function DUF4023 (DUF4023)
Type: Family

This family of proteins is functionally uncharacterised. There is a conserved KLP sequence motif.
Protein of unknown function DUF4013 (DUF4013)
Type: Family

This family consists of functionally uncharacterised proteins.
Protein of unknown function DUF4024 (DUF4024)
Type: Family

This family of proteins is functionally uncharacterised. There is a conserved RDE sequence motif.
Protein of unknown function DUF4025 (DUF4025)
Type: Family

This family of proteins is functionally uncharacterised. There is a conserved EGT sequence motif.
Protein of unknown function DUF4012 (DUF4012)
Type: Family

This is a family of uncharacterised proteins found in archaea and bacteria.
DUF4026, N-terminal (DUF4026_N)
Type: Domain

This entry represents a domain is found N-terminal in functionally uncharacterised bacterial proteins. This domain is found in association with

and

, that are located C-terminal.
Uncharacterized ATP-dependent helicase MG140 (DUF4011)
Type: Family

This family of proteins is found in archaea and bacteria. Many members are annotated as being putative DNA helicase-related proteins.
Protein of unknown function DUF4027 (DUF4027)
Type: Family

This family of proteins is functionally uncharacterised. There is a conserved CLGGF sequence motif.
Domain of unknown function DUF4010 (DUF4010)
Type: Domain

This domain is found in putative membrane proteins from archaea and bacteria.
Protein of unknown function DUF4028 (DUF4028)
Type: Family

This family of proteins is functionally uncharacterised. There are two conserved sequence motifs: IVKI and YVKKWF.
Protein of unknown function DUF4029 (DUF4029)
Type: Family

This family of proteins is functionally uncharacterised.
Protein of unknown function DUF4030 (DUF4030)
Type: Family

This family of proteins is functionally uncharacterised.
Domain of unknown function DUF4031 (DUF4031)
Type: Domain

This presumed domain is functionally uncharacterised. It contains a conserved HYD sequence motif.
AMP-binding enzyme, C-terminal domain (AMP-bd_C)
Type: Domain

This is a small domain that is found C-terminal to

in ATP-dependent AMP-binding enzymes from eukaryotes, bacteria and archaea, including Acetyl-coenzyme A synthetase (Acs). In Acs, this domain undergoes a large rotation to allow for both half-reaction to occur. It shows a central β-sheet core that is flanked by α-helices .
Domain of unknown function DUF4032 (DUF4032)
Type: Domain

This presumed domain is functionally uncharacterised. It is found in bacteria, and is approximately 170 amino acids in length.
Putative carbohydrate metabolism domain (PCMD)
Type: Domain

This domain has been suggested to participate in carbohydrate metabolism . Structural evidence indicates that it might be a carbohydrate binding domain, with or without enzymatic activity. In particular, it has been hypothesised that it might act as a glycoside hydrolase .
TRL-like protein family (TRL-like)
Type: Family

This family includes the

TRL protein that is found in a locus that includes several tRNAs. The function of this protein is not known . The proteins in this family usually have a lipoprotein attachment site at their N terminus.
Beta-carotene isomerase D27-like, C-terminal (D27-like_C)
Type: Domain

Beta-carotene isomerase D27 (also known as Protein DWARF-27) from plants is involved in strigolactones biosynthesis. It is a beta-carotene isomerase that converts all-trans-beta-carotene into 9-cis-beta-carotene, which is cleaved by CCD7 into a 9-cis-configured aldehyde . This is an iron-containing protein that localises in chloroplasts and is expressed mainly in vascular cells of shoots and roots . This entry also includes some uncharacterised proteins from bacteria.

This entry represents the C-terminal domain of Beta-carotene isomerase D27 that may contain an iron binding domain .
Domain of unknown function DUF4034 (DUF4034)
Type: Domain

This presumed domain is functionally uncharacterised. It contains a conserved PRW sequence motif.
Domain of unknown function DUF4037 (DUF4037)
Type: Domain

This presumed domain is functionally uncharacterised. There is a single completely conserved residue P that may be functionally important.
Domain of unknown function DUF4045 (DUF4045)
Type: Domain

This presumed domain is functionally uncharacterised.
Domain of unknown function DUF4046 (DUF4046)
Type: Domain

This presumed domain is functionally uncharacterised.
Domain of unknown function DUF4047 (DUF4047)
Type: Domain

This presumed domain is functionally uncharacterised. There are two conserved sequence motifs: TEA and FPKT.
GTPase HflX, N-terminal (GTPase_HflX_N)
Type: Domain

This domain represents the N-terminal region of GTP-binding HflX-like proteins . These proteins interact with the 50S ribosome and are GTPases, hydrolysing GTP/GDP/ATP/ADP . The N-terminal region is necessary for stability of the whole protein.
Domain of unknown function DUF4048 (DUF4048)
Type: Domain

This presumed domain is functionally uncharacterised.