SII-SWORD/CoKE huggingface dataset:
Protein of unknown function DUF6772 (DUF6772)
Type: Family

This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 292 and 316 amino acids in length. An AlphaFold prediction show similarity to the concanavalin superfamily suggesting that this family may be involved in carbohydrate binding.
Protein of unknown function DUF6773 (DUF6773)
Type: Family

This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 151 and 172 amino acids in length. This family has a conserved sequence motif DER and two conserved residues, a Tyr and a Gly.
Domain of unknown function DUF6774 (DUF6774)
Type: Domain

This presumed domain is found in a family of proteins that is functionally uncharacterised. This domain is found in firmicutes. There is a conserved sequence motif QLGDTL.
Protein of unknown function DUF6775 (DUF6775)
Type: Family

This family is functionally uncharacterised. This domain family is mainly found in archaea. An AlphaFold prediction shows close similarity to zinc dependent peptidases.
Domain of unknown function DUF6537 (DUF6537)
Type: Domain

This entry represents a presumed domain that is found normally found at the C-terminal end of prokaryotic sequences associated with

or with other enzyme domains. The function of this domain is unknown.
Domain of unknown function DUF6538 (DUF6538)
Type: Domain

This short presumed domain is found at the N-terminal of a variety of phage integrase proteins.
Protein of unknown function DUF6540 (DUF6540)
Type: Family

This entry contains a large diverse family of fungal proteins of unknown function.
Protein of unknown function DUF6541 (DUF6541)
Type: Family

This family is composed of a group of large bacterial integral membrane proteins that likely have a transporter function.
Protein of unknown function DUF6542 (DUF6542)
Type: Domain

This entry represents an integral membrane domain composed of four predicted transmembrane helices. The function of this region is unknown.
Dermonecrotic toxin, N-terminal domain (ToxA_N)
Type: Domain

This entry represents the N-terminal domain of bacterial proteins, such as the dermonecrotic toxin (ToxA, also known as PMT) from Pasteurella multocida, an osteolytic toxin that induces bone resorption. It is a potent mitogen. This toxin is associated with the severe progressive form of the atrophic rhinitis, a major respiratory disease in pigs. This domain contributes to the membrane localization of its C-terminal domains .
Protein of unknown function DUF6544 (DUF6544)
Type: Family

This entry represents a set of uncharacterised proteins found in bacteria and archaea.
Domain of unknown function DUF6545 (DUF6545)
Type: Domain

This entry represents a domain often found C-terminal in integral membrane proteins of unknown function, including Integral membrane protein from Mycobacterium abscessus (MAB_1171c,

, ). Proteins in this group are mainly found in Actinomycetes.
Domain of unknown function DUF6546 (DUF6546)
Type: Domain

This entry represents a domain found in uncharacterised fungal proteins. A few members contain an N-terminal F-box domain

.
Protein of unknown function DUF6547 (DUF6547)
Type: Family

This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 116 and 127 amino acids in length.
Protein of unknown function DUF6548 (DUF6548)
Type: Family

This family of proteins is functionally uncharacterised. This family of proteins is found in firmicutes. Proteins in this family are around 180 amino acids in length. They contain highly conserved motifs, YKxLD and I/LC at the N-terminal and LKxxRxxRN in the middle.
Protein of unknown function DUF6549 (DUF6549)
Type: Family

This family is functionally uncharacterised. It is mainly found in bacteroidetes, and is typically between 120 and 180 amino acids in length. There are two highly conserved residues, an aspartate and a tryptophan, and a NP conserved motif.
Protein of unknown function DUF6550 (DUF6550)
Type: Family

This family of proteins is functionally uncharacterised. This family of proteins is found in firmicutes. Proteins in this family are approximately 180 amino acids in length. There are two conserved sequence motifs at the C-terminal: FGW/I and I/VGxM.
Protein of unknown function DUF6551 (DUF6551)
Type: Family

This presumed domain is functionally uncharacterised. This domain family is found in bacteria, and is approximately 200 amino acids in length. Many sequences are related to ParB proteins, annotated as ParB-like or ParB domain-containing proteins. It contains the conserved motifs YQR, DGQH and EAxxF.
Protein of unknown function DUF6552 (DUF6552)
Type: Family

This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria, mainly proteobacteria. Proteins in this family are approximately 90 amino acids in length and some members are associated with Ubiquinone biosynthesis methyltransferases.
Protein of unknown function DUF6553 (DUF6553)
Type: Family

This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria, mainly firmicutes and actinobacteria. Proteins in this family are approximately 200 amino acids in length and contain the conserved motifs RY and DxF/Y
Protein of unknown function DUF6554 (DUF6554)
Type: Family

This family of proteins is functionally uncharacterised. This family of proteins is found in cyanobacteria. Proteins in this family are typically between 131 and 150 amino acids in length.
Protein of unknown function DUF6555 (DUF6555)
Type: Family

This family of proteins is functionally uncharacterised. This family of proteins is found in proteobacteria. Proteins in this family are typically between 76 and 94 amino acids in length.
Protein of unknown function DUF6556 (DUF6556)
Type: Family

This family of proteins is functionally uncharacterised. This family of proteins is found in firmicutes. Proteins in this family are typically between 130 and 155 amino acids in length. Some members are predicted histone acetyltransferases.
Protein of unknown function DUF6557 (DUF6557)
Type: Family

This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 140 and 200 amino acids in length. There is a quite conserved EMTFxxG motif.
DUF6558, N-terminal domain (DUF6558_N)
Type: Domain

This is a presumed domain found in uncharacterised proteins from firmicutes and phages, some members are phage tail-related proteins.
Protein of unknown function DUF6559 (DUF6559)
Type: Family

This family of proteins is functionally uncharacterised. This family of proteins is mainly found in gammaproteobacteria. Proteins in this family are approximately 120 amino acids in length. There are two conserved motifs, LxxxYG and Y/FT/SxxQI/V.
Protein of unknown function DUF6560 (DUF6560)
Type: Family

This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria, mainly firmicutes. Proteins in this family are typically between 157 and 193 amino acids in length. There are three highly conserved residues, tryptophan, phenylalanine/ tyrosine and lysine.
Protein of unknown function DUF6561 (DUF6561)
Type: Family

This family of proteins is functionally uncharacterised. This family of proteins is found in bacteriophages, mainly in Myovirus. Proteins in this family are approximately 80 amino acids in length. There are two conserved sequence motifs: EP and PxxxxxxxY.
Domain of unknown function DUF6562 (DUF6562)
Type: Domain

This domain is found in a family of proteins which is functionally uncharacterised. This is found in bacteroidetes. It contains the conserved motifs WAD, RP and TxxG. Some members are hypothetical Fimbrillin-A associated anchor protein Mfa1/Mfa2 and related to

.
Protein of unknown function DUF6563 (DUF6563)
Type: Family

This family of proteins is functionally uncharacterised. This family of proteins is found in bacteroidetes. Proteins in this family are around 230 amino acids in length. They contain the conserved motifs GGxDY and LYxNC in addition to three Y/F conserved residues.
Domain of unknown function DUF6564 (DUF6564)
Type: Domain

This domain is functionally uncharacterised and is found in proteins from bacteria and archaea. This domain is found in LicC proteins, CTP:phosphocholine cytidylyltransferases involved in LPS biosynthesis. Members containing this domain are annotated as nucleotidyltransferases. It is probable that this domain has a Rossmann-like fold.
Domain of unknown function DUF6565 (DUF6565)
Type: Domain

This domain is found in uncharacterised proteins, mainly from bacteroidetes and its function is unknown. It is approximately 60 amino acids in length. It contains a conserved motif DxxxW and a highly conserved tyrosine residue. It is related to apolipoproteins.
Domain of unknown function DUF6566 (DUF6566)
Type: Domain

This domain is found in functionally uncharacterised proteins, mainly from burkholderia. This domain is approximately 60 amino acids in length and it has a conserved tryptophan residue at the N-terminal, the conserved motifs PxW and AxRxxxE and an aspartate conserved residue at the C-terminal. Some members containing this domain are hypothetical transposases.
Protein of unknown function DUF6567 (DUF6567)
Type: Family

This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 120 amino acids in length. There is a conserved motif NF/Y and two conserved residues, a Cys and an Asn.
Protein of unknown function DUF6568 (DUF6568)
Type: Family

This family of proteins is functionally uncharacterised. This family of proteins is mainly found in firmicutes. Proteins in this family are approximately 170 amino acids in length. There are two conserved motifs, CxxF and YxN, and two conserved residues, Tyr at the N-terminal and a Gly at the C-terminal. Many members of this family are thought to belong to the Thioredoxin superfamily.
ARG and Rhodanese-Phosphatase-superfamily-associated domain (ARPP-1)
Type: Domain

ARPP-1 (ARG and Rhodanese-Phosphatase-superfamily-associated Protein domain 1) shows a distinguishing group of absolutely conserved residues, including a cysteine and a glutamine, suggestive of enzymatic activity. Structural predictions reveal a core β-sheet comprised of a duplicated four-stranded β-meander with a β-barrel domain bearing the absolutely conserved residues inserted into the first repeat. The unifying biochemical theme across its conserved contextual genome linkages is the presence of molecules with sugar moieties (ADPr, nucleotides, and polysaccharides). In genome contexts linking ARPP-1 with ARG and other counter viral ribosylation domains, ARPP is predicted to act on ribose moieties coming from ADPr. The presence of the conserved cysteine suggests that it could function analogous to the recently characterised SRAP domain by forming covalent cross-links with sugars .
Domain of unknown function DUF6570 (DUF6570)
Type: Domain

This entry represents a presumed domain of unknown function that is found in a wide range of eukaryotic proteins.
Domain of unknown function DUF6571 (DUF6571)
Type: Domain

This domain is found in functionally uncharacterised proteins found in Actinobacteria. According to structure predictions, this domain may adopt an α-helical fold.
Protein of unknown function DUF6572 (DUF6572)
Type: Family

This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 107 and 214 amino acids in length. These proteins may have a threefold symmetricβ-trefoil fold, a symmetric protein structure thought to be conserved in protein evolution .
Protein of unknown function DUF6776 (DUF6776)
Type: Family

This family of proteins is functionally uncharacterised. This family of proteins is found in proteobacteria. Proteins in this family are typically between 234 and 251 amino acids in length.
Domain of unknown function DUF6777 (DUF6777)
Type: Domain

This presumed domain is functionally uncharacterised. This domain family is mainly found in actinobacteria, and is approximately 160 amino acids in length.
Protein of unknown function DUF6778 (DUF6778)
Type: Family

This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria, predominantly in rhodobacteria. Proteins in this family are typically between 203 and 225 amino acids in length. This family contains the conserved sequence motifs DIVW, RFH and GGxH.
Domain of unknown function DUF6779 (DUF6779)
Type: Domain

This presumed domain is functionally uncharacterised. This domain family is mainly found in actinobacteria, and is approximately 100 amino acids in length.
Domain of unknown function DUF6780 (DUF6780)
Type: Domain

This presumed domain is functionally uncharacterised. This domain family is found at the C-terminal of fungal sequences, and is typically between 48 and 62 amino acids in length. The domain is found in association with

. There is a conserved sequence motif WxRHxAAxK that may be functionally important.
Protein of unknown function DUF6781 (DUF6781)
Type: Family

This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 223 and 298 amino acids in length.
Domain of unknown function DUF6782 (DUF6782)
Type: Domain

This domain found in bacteria is functionally uncharacterised. There is a conserved HEXRH sequence motif which is characteristic of metallopeptidase enzymes.
Protein of unknown function DUF6783 (DUF6783)
Type: Family

This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 61 and 97 amino acids in length.
Domain of unknown function DUF6784 (DUF6784)
Type: Domain

This presumed domain is found at the C-terminal of uncharacterised proteins from bacteria and archaea. It contains the conserved sequence motifs WW/FPLHPLGY and RxGG.
Domain of unknown function DUF6785 (DUF6785)
Type: Domain

This presumed domain is functionally uncharacterised and it is found in bacteria and archaea. There are highly conserved sequence motifs: FSxWFF and ExxxFP. There are eleven conserved tryptophan residues, which may suggest to play an important role.
Protein of unknown function DUF6786 (DUF6786)
Type: Family

This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and archaea. Proteins in this family are typically between 397 and 433 amino acids in length.
Domain of unknown function DUF6787 (DUF6787)
Type: Domain

This presumed domain is found in bacteria and fungi. It is functionally uncharacterised and is approximately 100 amino acids in length. Some members of this family are putative diacylglyceryl transferases.
Protein of unknown function DUF6607 (DUF6607)
Type: Family

This family of proteins is functionally uncharacterised. This family of proteins is predominantly found in bacteroidetes and proteobacteria. Proteins in this family are typically between 300 and 331 amino acids in length.
Protein of unknown function DUF6608 (DUF6608)
Type: Family

This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 130 amino acids in length.
Protein of unknown function DUF6609 (DUF6609)
Type: Family

This family of integral membrane proteins is functionally uncharacterised. This family of proteins is found mainly in firmicutes and actinobacteria. Proteins in this family are approximately 180 amino acids in length.
Protein of unknown function DUF6610 (DUF6610)
Type: Family

This family of proteins is functionally uncharacterised. This family of proteins is found in archaea, bacteria and viruses. Proteins in this family are typically between 304 and 335 amino acids in length.
Protein of unknown function DUF6611 (DUF6611)
Type: Family

This family of proteins is functionally uncharacterised. This family of proteins is found in actinobacteria. Proteins in this family are typically between 165 and 185 amino acids in length.
Protein of unknown function DUF6612 (DUF6612)
Type: Family

This family of proteins is functionally uncharacterised. However, based on similarity to other families it is likely to be involved in lipoprotein biosynthesis. This family of proteins is found in bacteria. Proteins in this family are typically between 263 and 293 amino acids in length.
Domain of unknown function DUF6613 (DUF6613)
Type: Domain

This domain is functionally uncharacterised, found in bacterial sequences. Proteins in this entry contain an N-terminal methylation site

suggesting these may be pilin proteins.
Protein of unknown function DUF6614 (DUF6614)
Type: Family

This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 120 amino acids in length.
Protein of unknown function DUF6615 (DUF6615)
Type: Family

This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 301 and 317 amino acids in length. These proteins contain a conserved sequence motif FREE that may be functionally important.
Protein of unknown function DUF6616 (DUF6616)
Type: Family

This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 120 amino acids in length.
Protein of unknown function DUF6617 (DUF6617)
Type: Family

This family of proteins is functionally uncharacterised. This family of proteins is found in bacteroidetes. Proteins in this family are typically between 315 and 341 amino acids in length.
Protein of unknown function DUF6618 (DUF6618)
Type: Family

This family of proteins is functionally uncharacterised. This family of proteins is found in firmicutes. Proteins in this family are typically between 98 and 116 amino acids in length.
Domain of unknown function DUF6619 (DUF6619)
Type: Domain

This presumed domain is functionally uncharacterised. This domain family is found in bacteria, and is approximately 100 amino acids in length.
Protein of unknown function DUF6620 (DUF6620)
Type: Family

This presumed domain is functionally uncharacterised. It is found in bacteria, mainly in bacteroidetes.
Protein of unknown function DUF6621 (DUF6621)
Type: Family

This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 200 amino acids in length.
Protein of unknown function DUF6622 (DUF6622)
Type: Family

This family of proteins is functionally uncharacterised, found in bacteria. Proteins in this family are approximately 170 amino acids in length.
Protein of unknown function DUF6623 (DUF6623)
Type: Family

This presumed domain is functionally uncharacterised, found in proteins from bacteria and eukaryotes.
Protein of unknown function DUF6624 (DUF6624)
Type: Family

This presumed domain is functionally uncharacterised. This domain is found in bacteria. Proteins in this family are typically between 188 and 316 amino acids in length.
Protein of unknown function DUF6625 (DUF6625)
Type: Family

This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and eukaryotes. Proteins in this family are typically between 292 and 338 amino acids in length.
Protein of unknown function DUF6626 (DUF6626)
Type: Family

This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 110 amino acids in length.
Protein of unknown function DUF6627, PA2779-like (PA2779-like)
Type: Family

This entry represents a group of proteins mainly found in proteobacteria, including PA2779 from Pseudomonas aeruginosa (

). The most distinctive feature is an extremely hydrophobic region at or near the C terminus, consisting almost entirely of the bulkier hydrophobic residues Val, Ile, Leu, and Phe. The function is unknown. Proteins in this family are approximately 130 amino acids in length.
Protein of unknown function DUF6628 (DUF6628)
Type: Family

This family of proteins is functionally uncharacterised. This family of proteins is found in proteobacteria. Proteins in this family are approximately 140 amino acids in length.
Protein of unknown function DUF6629 (DUF6629)
Type: Family

This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 212 and 228 amino acids in length.
Protein of unknown function DUF6788 (DUF6788)
Type: Family

This family of proteins is functionally uncharacterised. This family of proteins is mainly found in bacteria and archaea. Proteins in this family are around 100 amino acids in length. There are two conserved sequence motifs, CGxxxCxC containing three conserved Cys residues and HGP.
Protein of unknown function DUF6789 (DUF6789)
Type: Family

This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and archaea. These are likely membrane proteins.
Protein of unknown function DUF6790 (DUF6790)
Type: Family

This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and archaea. Proteins in this family are typically between 159 and 176 amino acids in length.
Domain of unknown function DUF6791 (DUF6791)
Type: Domain

This presumed domain is functionally uncharacterised. This domain family is found in bacteria, and is approximately 160 amino acids in length. The domain is found in sequences that belong to the Thif family and is in association with

, located at its N-terminal.
Domain of unknown function DUF6792 (DUF6792)
Type: Domain

This presumed domain is functionally uncharacterised. This domain is found in bacteria, and is around 250 amino acids in length. There is a conserved sequence motif GHSLGG. It may have an α/β hydrolase fold suggesting a catalytic role.
Protein of unknown function DUF6793 (DUF6793)
Type: Family

This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 110 amino acids in length. Proteins in this family might have an RNA polymerase activity.
Domain of unknown function DUF6794 (DUF6794)
Type: Domain

This domain is functionally uncharacterised, found in bacteria. It is around 120 amino acids in length. There is a conserved sequence motif GxxxRN.
Protein of unknown function DUF6675 (DUF6675)
Type: Family

This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria, mainly in spirochaetes. Proteins in this family are typically between 242 and 267 amino acids in length.
Bacterial Ig domain 15 (Big_15)
Type: Domain

This bacterial Ig-like domain is found in the stalk regions of bacterial cell surface adhesins.
RNAse III-like, virus (Mycovirus_RNAse)
Type: Domain

This domain is found in viruses infecting fungi (mycoviruses), either as a standalone domain in short proteins (e.g. in deltaflexiviruses), or in polyproteins (e.g. endornaviruses or hypoviruses). It is homologous to RNAse III domains (

,

) as seen using sequence-based searches. Its function is unknown.
HipA-like kinase (HipA_2)
Type: Domain

This entry represents a domain found in proteins that are distantly related to the HipA protein

. Members of this group of proteins are found in bacteria.
SHOCT-like domain (SHOCT_2)
Type: Domain

This entry represents a region related to the SHOCT domain found in bacteria and viruses that are functionally uncharacterised.