SII-SWORD/CoKE huggingface dataset:
Protein of unknown function DUF7097 (DUF7097)
Type: Family

This protein family includes a group of proteins from halobacteria. It shows several conserved motifs DCPH, RGCL and RPLL/VEEHHLSxY. Members are predicted to show an α-β configuration.
Domain of unknown function DUF7099 (DUF7099)
Type: Domain

This is a β-propeller domain found in a group on uncharacterised proteins from fungi. The function of this domain is unknown.
Domain of unknown function DUF7100 (DUF7100)
Type: Domain

This is an α-helical domain found at the N-terminal of a group of uncharacterised proteins from fungi. The function of this domain is unknown. Members of this entry also have a β-propeller at the C-terminal (

).
Domain of unknown function DUF7101 (DUF7101)
Type: Domain

This is a domain found in a group on uncharacterised proteins from fungi. The function of this domain is unknown. According to structural predictions, this domain likely adopts an α-β-β-β-β-α fold. This domain is usually found associated with an α-helical domain at the N-terminal

and a β-propeller at the C-terminal

.
Domain of unknown function DUF7102 (DUF7102)
Type: Domain

This domain has a restriction endonuclease-like fold. The function of these proteins is unknown. Some members of the family are annotated as nucleoporins.
Protein of unknown function DUF7103 (DUF7103)
Type: Family

This is a family of unknown function. It is structurally similar to Frag1-like domain, composed of a six-α-helix bundle transmembrane region .
Repeat of unknown function DUF7104 (DUF7104)
Type: Repeat

This entry includes uncharacterised fungal sequences which consist of repeats that may adopt an α-solenoid structure related to ankyrin repeats. The overall arrangement of these repeats may have a horseshoe conformation similar to that in leucine-rich repeats.
Domain of unknown function DUF7107 (DUF7107)
Type: Domain

This entry represents a family of uncharacterised domains that show similarities to members of the colipase superfamily/
DUF7108, N-terminal domain (DUF7108_N)
Type: Domain

This domain is found at the N-terminal end of the uncharacterised protein HVO_0731 from Haloferax volcanii (

) and similar proteins from halobacteria. It has several conserved motifs RLTR/KLxR and LVxHPxEW and is predicted to adopt an α-β structure. The function of this domain is unknown.
Protein of unknown function DUF7109 (DUF7109)
Type: Family

This family represents a group of proteins from halobacteria. It has several conserved motifs LAGV/IVDLFG, DxPHI and LxDVxYD/ExExW and five highly conserved R residues. Members are predicted to show a mainly α-helical structure with a small β-sheet.
Protein of unknown function DUF7110 (DUF7110)
Type: Family

This family represents a group of proteins from halobacteria. Members are predicted to show an α-β configuration.
Protein of unknown function DUF7111 (DUF7111)
Type: Family

This family represents a group of proteins from halobacteria. It has several conserved motifs AxYxET, ERxL/VxF and GYAMLK/RVR. Members are predicted to show a β-sheet and an α-helix.
Protein of unknown function DUF7112 (DUF7112)
Type: Family

This family represents a group of proteins from halobacteria. It has several conserved R, D W and Y residues. Members are predicted to show a mainly beta configuration.
Protein of unknown function DUF7113 (DUF7113)
Type: Family

This family represents a group of proteins from halobacteria. It has several conserved motifs YVWVCD, RGF and RTQFxR. Members are predicted to show an α-β configuration.
Protein of unknown function DUF7114 (DUF7114)
Type: Family

This family represents a group of proteins from halobacteria. It has several conserved motifs GVQLIYEGLR, EPW and GR/K/QxQT/S. Members are predicted to show an all-alpha configuration.
Domain of unknown function DUF7115 (DUF7115)
Type: Domain

This domain is found at the N-terminal of HVO_2519 from Haloferax volcanii (

) and similar proteins mainly from halobacteria. It has several conserved motifs RTxxYR, Y/FxHxxxR an RRK. It is predicted to show an α-β configuration.
Protein of unknown function DUF7116 (DUF7116)
Type: Family

This family represents a group of proteins from halobacteria. It has several conserved motifs LGY, AERK/EWK/R, RCFV and YxWA. Members are predicted to show an α-β configuration.
Protein of unknown function DUF7117 (DUF7117)
Type: Family

This family represents a group of proteins from halobacteria. It has several conserved motifs WSYY, RxYxR and HxK/RR. Members are predicted to show a predominantly alpha configuration.
Protein of unknown function DUF7118 (DUF7118)
Type: Family

This family represents a group of proteins from halobacteria. Members are predicted to adopt an all-alpha structure.
Domain of unknown function DUF7119 (DUF7119)
Type: Domain

This domain is found in a group of uncharacterised proteins mainly from archaea. It is predicted to adopt an all-helical configuration.
Protein of unknown function DUF7120 (DUF7120)
Type: Family

This family represents a group of proteins from halobacteria. Members are predicted to adopt an α-helical configuration.
Protein of unknown function DUF7121 (DUF7121)
Type: Family

This family represents a group of proteins mainly from halobacteria. Members are predicted to show an alpha- helical configuration.
Domain of unknown function DUF7122 (DUF7122)
Type: Domain

This domain is found in a group of proteins from halobacteria. Members are predicted to show an α-β configuration.
Domain of unknown function DUF7123 (DUF7123)
Type: Domain

This domain is found in a group of proteins mainly from halobacteria. It is predicted to show an HTH fold.
Domain of unknown function DUF7124 (DUF7124)
Type: Domain

This domain is found in a group of proteins from halobacteria. It has several W and R conserved residues. This domain is predicted to show an α-β configuration.
Protein of unknown function DUF7125 (DUF7125)
Type: Family

This family represents a group of proteins from halobacteria. Members are predicted to show an α-β configuration with similarity to the KaiC domain (Pfam:PF06745).
Protein of unknown function DUF7126 (DUF7126)
Type: Family

This family represents a group of proteins from halobacteria. Members are predicted to show an α-β configuration with similarity to the Rossmann fold of the TrkA-N domain (

).
Protein of unknown function DUF7127 (DUF7127)
Type: Family

This family represents a group of proteins from halobacteria. Members adopt a beta configuration with high similarity to the CS domain (Pfam:PF04969).
Domain of unknown function DUF7128 (DUF7128)
Type: Domain

This domain is found in a group of small proteins mainly from Halobacteria. It contains highly conserved cysteine and histidine residues arranged in two CxxC and HxxC motifs that likely coordinate zinc. This domain is predicted to adopt a fold similar to the classical C2H2 and variant C2HC zinc fingers containing β-hairpin and an α helix. In addition, it is predicted to contain an extra N-terminal strand that contributes to the formation of a three-stranded antiparallel β-sheet. This domain also has a number of highly conserved negatively charged residues.
Domain of unknown function DUF7129 (DUF7129)
Type: Domain

This domain is found in a group of small proteins mainly from Halobacteria. It contains highly conserved cysteine residues arranged in two CxxC motifs that likely coordinate zinc. The first motif could be more broadly defined as YECxxCG. This domain is predicted to adopt zinc ribbon fold.
Domain of unknown function DUF7130 (DUF7130)
Type: Domain

This domain is found in a group of uncharacterised proteins mainly from Halobacteria. It contains highly conserved cysteine residues arranged in two CxxC motifs that likely coordinate zinc. The first motif could be more broadly defined as a semi-conserved MWRCxxCGEM sequence motif. This domain is predicted to adopt a zinc ribbon fold with similarity to rubredoxin-like domains.
PA-PLA1 probable phospholipase, DUF7131 (PA-PLA1_DUF7131)
Type: Domain

This entry represents a domain of unknown function found in some members of the PA-PLA1 family, which consists of mitochondrial proteins that are probable phospholipases with a specific function to hydrolyse phosphatidic acid. Members of this group are likely to be involved in the metabolism of phospholipids, which are critical components of cell membranes. By hydrolysing phosphatidic acid, these enzymes may play a role in the regulation of mitochondrial membrane composition and dynamics, as well as in signalling pathways related to lipid metabolism.
Protein of unknown function DUF7132 (DUF7132)
Type: Family

This entry represents a small family from archaebacteria based on protein PF1546. AlphaFold models show that a dimer of this protein forms a flattened 10 stranded β barrel structure.
L-sorbosone dehydrogenase-like (SNDH-like_dom)
Type: Domain

This domain is found in L-sorbosone dehydrogenase from Gluconacetobacter liquefaciens and related sequences from bacteria. It is predicted to form a a six-bladed β-propeller.
Domain of unknown function DUF7134 (DUF7134)
Type: Domain

This domain is composed of six transmembrane α-helices and is found at the N terminus of a large family of bacterial signalling proteins. It is structurally related to the N terminus of the DesK protein. This region is believed to be involved in sensing membrane fluidity.
CYPRO4-like, N-terminal DUF7135 (CYPRO4_DUF7135)
Type: Domain

This domain of unknown function is found N-terminal in a group of uncharacterised proteins specific to plants, including Protein CYPRO4 from Cynara cardunculus (cardoon). This domain is predicted to adopt a β-barrel with topology typical for PH domains. It has a weak sequence similarity to Dcp1 PH domain.
Domain of unknown function DUF7136 (DUF7136)
Type: Domain

This domain is found in a group of uncharacterised proteins mainly from Fungi. It is predicted to fold into a β-sandwich with Ig-like topology.
Domain of unknown function DUF7137 (DUF7137)
Type: Domain

This domain is found in a group of uncharacterised proteins mainly from Fungi. It is predicted to adopt a β-sandwich with Ig-like topology and is likely distantly related to the delta subunit of translocon-associated protein (TRAP-delta,

).
Domain of unknown function DUF7138 (DUF7138)
Type: Domain

This domain is found in uncharacterised proteins mainly from plants. It has sequence similarity to PB1 domain and it is predicted to adopt similar structure with typical ubiquitin-like topology.
Domain of unknown function DUF7139 (DUF7139)
Type: Domain

This entry represents a family of 4 transmembrane helix domains found in archaebacteria. In some proteins these domains are associated with repeats of the

domain. AlphaFold predicts a confident dimeric structure for this domain.
Domain of unknown function DUF7140 (DUF7140)
Type: Domain

This entry represents a likely zinc-binding domain found at the C terminus of a set of archaebacterial proteins. AlphaFold prediction shows a structure forming 2-3 β-strands.
Domain of unknown function DUF7141 (DUF7141)
Type: Domain

This domain is found in uncharacterised proteins mainly from Fungi. These proteins are likely involved in chromatin remodelling. The domain represented by this entry is predicted to fold into a globular structure with significant similarity to chromo domain (Pfam:PF00385).
Putative E3 ubiquitin-protein ligase LIN, ARM-like domain (ARM_LIN)
Type: Domain

This entry represents a domain found in a group of plant proteins, including the putative E3 ubiquitin-protein ligase LIN from Medicago truncatula. This domain may adopt an ARM-repeat fold.

E3 ubiquitin-protein ligase LIN is involved in the rhizobial infection process . This protein plays an important role in the early steps of bacterial symbiont thread formation in roots, and in growth, differentiation and maintenance of nodules .
Domain of unknown function DUF7143 (DUF7143)
Type: Domain

This domain is found in a group of uncharacterised fungal proteins. It is predicted to adopt a globular α-helical structure.
Domain of unknown function DUF7144 (DUF7144)
Type: Domain

This domain is found in uncharacterised bacterial proteins. It is predicted to fold into a four-helical up-and-down bundle and it is likely transmembrane.
Domain of unknown function DUF7145 (DUF7145)
Type: Domain

This entry represents a domain of unknown function found in Trichuris sp., Trichinella sp. and similar sequences from nematodes. This domain is repeated in some sequences from Trichuris spp. (two to four times) and it may adopt a SH2-like fold.
Domain of unknown function DUF7146 (DUF7146)
Type: Domain

This domain is found in uncharacterised bacterial proteins. It has significant sequence similarity to the alpha+beta domain found in DNA primases and it is predicted to adopt similar structure.
Domain of unknown function DUF7147 (DUF7147)
Type: Domain

This domain is found in uncharacterised bacterial proteins. It is predicted to fold into an alpha/beta globular structure with topology similar to NADH-quinone oxidoreductase subunit 16.
Domain of unknown function DUF7148 (DUF7148)
Type: Domain

This domain is found in uncharacterised plant proteins. It is predicted to fold into an α/β structure that is topologically similar to BRSK1/2 KA1 domain (

).
Domain of unknown function DUF7149 (DUF7149)
Type: Domain

This domain is found in related bacterial proteins. It is predicted to adopt an alpha/beta globular structure and shares significant sequence and structural similarity to members of PD-(D/E)XK nuclease superfamily, in particular, BpuSI N-terminal nuclease domain (Pfam:PF15516).
Domain of unknown function DUF7151 (DUF7151)
Type: Domain

This entry represents a domain of unknown function found in bacterial and archaeal proteins. Some of the members of this family might contain an EF-hand calcium binding site. The predicted structure of this domain consists of three β-sheets.
Domain of unknown function DUF7152 (DUF7152)
Type: Domain

This domain is found in plant proteins that are probably related to NOMO family of proteins. The latter are components of the multi-pass translocon (MPT) complex which mediates insertion of multi-pass membrane proteins into the lipid bilayer of membranes . The domain represented by this entry is predicted to adopt a globular β-sandwich structure with a prealbumin-like topology.
Domain of unknown function DUF7153 (DUF7153)
Type: Domain

This domain is found in Caenorhabditis elegans uncharacterised protein C01C4.2 and related proteins. It is predicted to adopt an α+β barrel with some similarity to the dimeric α+β barrel structures, in particular REDY-like protein Hapk (

).
Domain of unknown function DUF7154 (DUF7154)
Type: Domain

This domain is found in the Caenorhabditis elegans uncharacterised protein Clec-72 and related eukaryotic proteins. It is predicted to adopt a globular structure with similarity to Galactose-binding domains.
Protein of unknown function DUF7155 (DUF7155)
Type: Family

This protein family includes a group of uncharacterised short sequences from actinobacteria, including the predicted secreted protein

from Mycolicibacterium hassiacum .
Protein of unknown function DUF7156 (DUF7156)
Type: Family

This protein family includes a group of uncharacterised short sequences from actinobacteria .
Domain of unknown function DUF7157 (DUF7157)
Type: Domain

This domain is found at the C-terminal end of a group of uncharacterised sequences from actinobacteria.
Protein of unknown function DUF7158 (DUF7158)
Type: Family

This domain is found at the N-terminal end of a group of uncharacterised sequences from actinobacteria.
Domain of unknown function DUF7159 (DUF7159)
Type: Domain

This domain is found at the C-terminal end of a group of uncharacterised sequences from actinobacteria. It is normally found associated with

.
Protein of unknown function DUF7160 (DUF7160)
Type: Family

This protein family includes a group of uncharacterised short sequences from actinobacteria.
Protein of unknown function DUF7161 (DUF7161)
Type: Family

This protein family includes a group of uncharacterised short sequences from actinobacteria. Many members are annotated as UbiD family decarboxylases. They are predicted to adopt an all beta configuration.
Protein of unknown function DUF7162 (DUF7162)
Type: Family

This protein family includes a group of uncharacterised short sequences from actinobacteria. Some members are annotated as ESX-1 secretion-associated proteins. They are predicted to adopt a mainly α-helical configuration.
Domain of unknown function DUF7163 (DUF7163)
Type: Domain

This domain is found N-terminal in a group of uncharacterised proteins from Trypanosomes. It has a very weak similarity to the vWA-like domain of the SSL1 subunit of general transcription and DNA repair factor IIH and it is predicted to adopt a structure with similarity to known vWA-like domains.
Domain of unknown function DUF7164 (DUF7164)
Type: Domain

This domain is found either standalone or in tandem in uncharacterised eukaryotic proteins. It has a weak sequence similarity to Nucleotide-diphospho-sugar transferases, in particular to Glycolipid 2-alpha-mannosyltransferases (Pfam:PF01793) and is predicted to adopt similar structure.
Domain of unknown function DUF7165 (DUF7165)
Type: Domain

This entry represents a domain of unknown function found towards the N-terminal of mainly fungal proteins. This domain adopts a β-propeller like fold and may be found in association with an N-terminal F-box motif.
TscA antitoxin (TscA)
Type: Family

This protein family, previously known as DUF7166, is found in a variety of staphylococcus phage. It was shown to be the antitoxin TscA of a toxin-antitoxin system , with TscT being the toxin

. It is composed of two α helices and a β hairpin and shows weak structural similarity to archaeal prefoldins. Members of this family form a confident homodimer structure with AlphaFold 3.
Domain of unknown function DUF7167 (DUF7167)
Type: Domain

This small phage protein forms a predicted strand swapped dimer using AlphaFold. It is composed of three β strands and two α helices. There is also some weaker evidence for a tetramer. The function of these proteins is unknown.
Domain of unknown function DUF7168 (DUF7168)
Type: Domain

This entry represents a protein domain found in phage proteins that usually contain an N-terminal

. The function of these protein is unknown.
Protein of unknown function DUF7169 (DUF7169)
Type: Family

This family consists of a group of uncharacterised proteins, typically between 99 to 116 amino acids in length, found in bacteriophages that infect Microbacterium and Arthrobacter bacterial hosts. These proteins are encoded in the genomes of phages belonging to the Caudoviricetes class, primarily within the families Azeevirinae, Dismasvirus, Yangvirus, Manhattanvirus, Liebevirus, Zetavirus, and Armstrongvirus. An AlphaFold prediction shows these proteins are composed of two α helices. AlphaFold also predicts that these proteins likely form homodimers.
Protein of unknown function DUF7170 (DUF7170)
Type: Family

This family consists of several uncharacterised phage proteins of around 50 amino acids in length. The family is found in a variety of phages that infect bacterial hosts such as Escherichia, Salmonella, Klebsiella, Vibrio, Citrobacter, Shigella, Pseudomonas and Aeromonas. A few longer proteins of around 60-90 amino acids are also included.
Protein of unknown function DUF7171 (DUF7171)
Type: Family

This entry represents a domain of unknown function found in bacterial and phage proteins, particularly in Gordonia phages. The domain is approximately 140 amino acids in length. It contains regions of disorder at the N- and C-termini.
Domain of unknown function DUF7172 (DUF7172)
Type: Domain

This entry represents a domain found in proteins typically around 200 amino acids in length. It is found in phage that infect Mycobacteria, Gordonia, and Nocardia. The exact function is unknown. The structure of the domain shows an extended β sandwich fold where one sheet is hinged in the middle to form a kink.
Protein of unknown function DUF7173 (DUF7173)
Type: Family

This family contains a set of uncharacterised proteins found predominantly in viruses, particularly bacteriophages. The proteins are typically 130-150 amino acids in length. AlphaFold models of this family show some weak partial structural similarity to the Recombination-associated protein RdgC.
Protein of unknown function DUF7174 (DUF7174)
Type: Family

This protein is found in caudoviruses, which are tailed bacteriophages. The protein is typically around 150-180 amino acids in length. Its function is currently unknown. It is found in viruses from the Drexlerviridae family, including Rogunavirinae, Braunvirinae, Tempevirinae, and Kyungwonvirus genera.
Protein of unknown function DUF7175 (DUF7175)
Type: Family

This entry represents an uncharacterised protein family found in various phages infecting Gram-negative bacterial hosts, including Salmonella, Shigella, Erwinia, Aeromonas, Vibrio and Klebsiella phages. The family typically contains proteins between 80-120 amino acids in length. The function of this protein family is currently unknown.
Protein of unknown function DUF7176 (DUF7176)
Type: Family

This family consists of short bacterial phage proteins, typically around 90 amino acids in length, that contain two transmembrane helices. The family is found in phages that infect Enterobacteria.
Protein of unknown function DUF7177 (DUF7177)
Type: Family

The domain is around 80 amino acids in length. It occurs in phage that infect a variety of bacteria including Escherichia, Salmonella, Shigella, Klebsiella, Vibrio, Pantoea, Pectobacterium, Yersinia and Serratia.
Protein of unknown function DUF7178 (DUF7178)
Type: Family

This entry describes a family of identified in phage metagenomic datasets. The family contains proteins from a variety of phages that infect actinobacteria, particularly Mycobacterium, Gordonia, and Streptomyces. The exact specificity and function of this metagenomic family is currently unknown. Some members are described as N-glycosylases but the source of that information is uncertain.
Protein of unknown function DUF7179 (DUF7179)
Type: Family

This entry represents an uncharacterised protein domain found in phage, predominantly those infecting bacteria in the Enterobacteriaceae family such as Escherichia, Salmonella, Klebsiella and Vibrio. The protein is typically around 80 to 100 amino acids in length. In some phage the protein contains a predicted central coiled-coil region. The function of this protein family is currently unknown.
Protein of unknown function DUF7180 (DUF7180)
Type: Family

This entry represents an uncharacterised protein that is found in a variety of phage, predominantly infecting bacteria from the Enterobacteriaceae family such as Escherichia and Salmonella. The protein is typically between 75-120 amino acids in length. These proteins have a highly conserved N terminus.
Domain of unknown function DUF7181 (DUF7181)
Type: Domain

This entry represents an uncharacterised protein domain found in bacteriophage proteins, particularly those infecting Salmonella and Dickeya species. The domain is approximately 150 residues in length. The function of this domain is currently unknown.
Protein of unknown function DUF7182 (DUF7182)
Type: Family

This entry represents an uncharacterised protein found in various mycobacteriophages. The protein contains a predicted transmembrane helix and is typically around 60 amino acids in length. Its function is unknown.
Domain of unknown function DUF7183 (DUF7183)
Type: Domain

This entry represents an uncharacterised protein domain found in various mycobacteriophages. The domain averages around 150 amino acids in length. It is found as a single domain in the phage proteins. The function of this domain is currently unknown. One protein in this family

contains an N-terminal associated domain

.
Anti-DarT factor A-like (AdfA-like)
Type: Family

This entry represents Anti-DarT factor A from Escherichia phage RB69 (AdfA) and similar phage proteins. AdfA plays a role in counteracting the host DarT defense system, when mutated at Arg-164 .