SII-SWORD/CoKE huggingface dataset:
Domain of unknown function DUF4770 (DUF4770)
Type: Domain

This presumed domain is functionally uncharacterised. This domain is found in insects, and is typically between 169 and 182 amino acids in length. There is a single completely conserved residue L that may be functionally important.
Domain of unknown function DUF4771 (DUF4771)
Type: Domain

This domain is found in proteins from insects. There is a conserved RYGK sequence motif.
PNN-interacting serine/arginine-rich protein (PNISR)
Type: Family

Pinin (PNN) has been identified as central in the establishment and maintenance of corneal epithelial cell-cell adhesion. Three SR-rich proteins have been identified that interact with the C terminus of PNN; one of them is this 130kDa nuclear protein, SRrp130, also known as PNISR . SRrp130 is a protein of 805 amino acid residues with multiple arginine-serine (RS) repeats but had no RNA recognition motif . Its function is unknown.
Protein inscuteable homologue, LGN-binding domain (INSC_LBD)
Type: Domain

This is the LGN-binding domain (LBD) of the inscuteable homologue protein. It interacts with the TPR motifs of G-protein-signaling modulator 2 (GPSM2, also known as LGN) and stabilises LGN .
Surface-adhesin protein E-like (Adhesin_E-like)
Type: Domain

Adhesin E plays a role in pathogenesis . It binds to host proteins including plasminogen, vitronectin and laminin . This entry also includes putative uncharacterised protein YjhD from E. coli.
Domain of unknown function DUF4772 (DUF4772)
Type: Domain

This presumed domain is functionally uncharacterised. This domain is found in eukaryotes, and is typically between 107 and 124 amino acids in length. There is a single completely conserved residue V that may be functionally important.
Domain of unknown function DUF4773 (DUF4773)
Type: Domain

This presumed domain is functionally uncharacterised. This domain family is found in eukaryotes, and is approximately 120 amino acids in length.
Domain of unknown function DUF4774 (DUF4774)
Type: Domain

This presumed domain is functionally uncharacterised. This domain is typically found in insects, and is approximately 50 amino acids in length.
CARMIL, C-terminal domain (CARMIL_C)
Type: Domain

This domain is found near to the C terminus of leucine-rich repeat-containing proteins in the CARMIL family, whose members are potential regulators of actin capping proteins. In leucine-rich repeat-containing protein 16A (LRRC16A) it includes the region responsible for interaction with F-actin-capping protein subunit alpha-2 (CAPZA2) .
Ribosome biogenesis GTPase RsgA, N-terminal (RsgA_N)
Type: Domain

This domain has an OB fold and is found at the N terminus of bacterial circularly permutated GTPase RsgA/YloQ . RsgA is a late-stage ribosome biogenesis factor involved in the 30S subunit maturation .
Protein of unknown function DUF4775 (DUF4775)
Type: Family

This family of insect proteins is functionally uncharacterised. Proteins in this family are typically between 308 and 484 amino acids in length.
KIAA1045, RING finger (KIAA1045_Zf_RING)
Type: Domain

This entry represents a zinc finger domain found in the uncharacterised protein from animals KIAA1045.
Headcase, middle domain (Headcase_mid)
Type: Domain

This domain is found in Drosophila headcase protein and the human headcase protein homologue. Drosophila headcase protein is involved in dendrite pruning and is a branching inhibitor during tracheal development . It also promotes cell survival and niche maintenance in the Drosophila testis . Human headcase protein may play an important role in human carcinogenesis .
Periplasmic lysozyme inhibitor, I-type (PliI)
Type: Family

This entry includes the PliI protein from Aeromonas hydrophila (PliI-Ah). PliI is a dimeric periplasmic protein that enables bacteria to resist permeabilisation of the outer membrane by the bactericidal action of lysozyme. PliI achieves its inhibitory action via an insertion of a loop containing the conserved SGxY motif into the active centre of I-type lysozymes .
Domain of unknown function DUF4776 (DUF4776)
Type: Domain

This presumed domain is functionally uncharacterised. This domain family is found in insects, and is typically between 444 and 485 amino acids in length. There is a conserved TLR sequence motif.
116kDa U5 small nuclear ribonucleoprotein component, N-terminal (EFTUD2_N)
Type: Domain

This entry represents the N-terminal domain of U5 small nuclear ribonucleoprotein (snRNP) protein (U5-116kDa). It is also found in Snu114p, a 114kDa protein homologous to U5-116kDa that has been identified in Saccharomyces cerevisiae . Both proteins seem to have a role in pre-mRNA splicing process.
Interleukin 17 receptor D, N-terminal (IL17R_D_N)
Type: Domain

This entry represents the N-terminal domain of interleukin-17 receptor D (IL17RD) . The function of this domain is not known.
KH-like RNA-binding domain (MOEP19_KH-like)
Type: Domain

This entry represents a KH-like RNA-binding motif found in MOEP19 (also known as Ooep19 or Floped) , Filia (also known as Ecat or KH domain-containing protein 3) , and related proteins.

MOEP19 is a mammalian protein expressed during early embryogenesis . Filia is expressed in oocytes and embryo . RNA-binding domain may mediate RNA transcript regulation in oogenesis and embryogenesis.
mRNA-decapping enzyme, C-terminal (mRNA_decap_C)
Type: Domain

This entry represents the C-terminal domain of animal mRNA-decapping enzyme DCP1 that is responsible for its trimerisation. DCP1 trimerisation is required for its incorporation into active decapping complexes and for efficient mRNA decapping in vivo. The structure of this domain has been revealed .
Domain of unknown function DUF4777 (DUF4777)
Type: Domain

This presumed domain is functionally uncharacterised. This domain is found in proteins from insects, and is approximately 70 amino acids in length.
Protein of unknown function DUF4778 (DUF4778)
Type: Family

This family of insect proteins is functionally uncharacterised. Proteins in this family are typically between 321 and 791 amino acids in length. There is a single completely conserved residue P that may be functionally important.
Protein of unknown function DUF4779 (DUF4779)
Type: Family

This family of insect proteins is functionally uncharacterised.
Domain of unknown function DUF4780 (DUF4780)
Type: Domain

This presumed domain is functionally uncharacterised. This domain is found in insect proteins, and is typically between 132 and 144 amino acids in length. There is a single completely conserved residue W that may be functionally important.
Domain of unknown function DUF4781 (DUF4781)
Type: Domain

This presumed domain is functionally uncharacterised. It is typically between 288 and 306 amino acids in length.
Histone deacetylase complex subunit SAP130, C-terminal domain (SAP130_C)
Type: Domain

SAP130 (Sin3-associated protein 130) is a component of the histone deacetylase-dependent co-repressor complex mSin3A that acts as a transcriptional repressor. It may function in the assembly and/or enzymatic activity of mSin3A or in mediating interactions between the complex and other regulatory complexes .

This entry represents the C-terminal domain of SAP130.
Caspase recruitment domain (CARD_dom)
Type: Domain

This entry represents the CARD domain found in the DDX58 protein (also known as RIG1), which is a key protein in the cellular chordates' sentinel system to detect viral infection. This domain is near the N terminus of RIG1 and interacts with its C-terminal domain .
Starch-binding module 26 (CBM26)
Type: Domain

CBM26 is a carbohydrate-binding module that binds starch .
PHD finger protein 12, MRG binding domain (PHF12_MRG-bd)
Type: Domain

This domain found in PHF12 (PHD finger protein 12, also known as
Pf1) binds to the MRG domain of mortality factor 4-like protein 1 (MORF4L1, also known as MRG15) . In mammals, the corepressor Sin3B, the histone deacetylase HDAC1, MRG15 and Pf1 form a complex that plays important roles in regulation of transcription .
PhoR, single Cache-like domain (PhoR_single_Cache-like_dom)
Type: Domain

This entry represents the N-terminal Cache-like domain of the alkaline phosphatase synthesis sensor protein PhoR. It covers part of the PAS-like fold that share a central five-stranded β-sheet of identical topology to other PAS domains .

Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins, including the animal dihydropyridine-sensitive voltage-gated Ca2 channel alpha-2delta subunit, and various bacterial chemotaxis receptors. The name Cache comes from CAlcium channels and CHEmotaxis receptors.
VASt domain (VASt)
Type: Domain

The VASt (VAD1 Analog of StAR-related lipid transfer) domain is conserved across eukaryotes and is structurally related to Bet v1-like domains, including START lipid-binding domains. The ~190-amino acid VASt domain is predominantly associated with lipid binding domains such as GRAM, C2 and PH domains. The VASt domain is likely to have a function in binding large hydrophobic ligands and may be specific for sterol .

The predicted structure of the VASt domain is a two-layer sandwich α/β fold, also called "helix grip fold", containing three α-helices (α1 to 3), six β-sheets (β1 to 6) and two loops (ω1 and 2) numbered from N to C terminus .

Some proteins known to contain a VASt domain are listed below:

Plant vascular associated death1 (VAD1), a regulator of programmed cell death (PCD) harboring a GRAM putative lipid-binding domain.

Yeast SNF1 Interacting Protein 3 (SIP3), may be involved in sterol transfer between intracellular membranes.

Yeast Suicide Protein 1 (YSP1), a mitochondrial protein specifically required for the mitochondrial thread-grain transition, de-energization, and the cell death. May be involved in sterol transfer between intracellular membranes.

Yeast Suicide Protein 2 (YSP2), a mitochondrial membrane protein involved in mitochondrial fragmentation. May be involved in sterol transfer between intracellular membranes.

Human GramD1a-c.
Anillin, N-terminal domain (Anillin_N)
Type: Domain

This domain is found towards the N terminus of anillin (ANLN), a F-actin-binding protein with important roles in cell cytokinesis . In mammalian anillin, this domain is repeated. This domain overlaps with the region responsible for nuclear localisation of anillin .
Unconventional myosin-X, coiled coil domain (MYO10_CC)
Type: Domain

This coiled coil domain is found in unconventional myosin-X and is responsible for its dimerisation .
Cysteine/serine-rich nuclear protein, N-terminal domain (CSRNP_N)
Type: Domain

This presumed domain is found at the N terminus of cysteine/serine-rich nuclear proteins. These proteins act as transcriptional activators .
Deltamethrin resistance protein prag01 (Deltameth_res_prag01)
Type: Domain

This presumed domain is found in the deltamethrin-resistance protein prag01 (

) from Culex pipiens pallens .
Programmed cell death protein 7 (PDCD7)
Type: Family

Programmed cell death protein 7 (PDCD7, ES18) may be involved in specific apoptotic processes . This entry also includes Arabodopsis At2g46200 protein, which is predicted to be U11/U12 small nuclear ribonucleoprotein .
Type IV pilin-like putative secretion pathway protein G/H (Pilin_GH)
Type: Family

This entry represents a family from Cyanobacteria. All the proteins are putatively annotated as being general secretion pathway proteins G and H, and are likely to be pilins of the type IV secretory pathway.
Rhomboid protease, N-terminal (NRho)
Type: Domain

Rhomboids are integral membrane proteases that release cellular signals from membrane-bound substrates through a general signal transduction mechanism known as regulated intramembrane proteolysis (RIP).

This entry represents the N-terminal cytosolic domain of rhomboid intramembrane proteases from Pseudomonas. This domain, known as NRho, consists of a novel α/β fold and displays a strong and specific association with micelles of the zwitterionic lysophospholipid-analogue C16PN .
Protein of unknown function DUF4783 (DUF4783)
Type: Family

This family of proteins is found in bacteria. Proteins in this family are approximately 130 amino acids in length. There is a single completely conserved residue F that may be functionally important.
Domain of unknown function DUF4784 (DUF4784)
Type: Domain

This is a domain found in a group of uncharacterised proteins from Bacteroidetes. It is predicted to adopt a 6-bladed β-propeller structure.
DUF4785, N-terminal domain (DUF4785_N)
Type: Domain

This entry represents the N-terminal jelly roll domain found in a group of proteins mainly from proteobacteria. Proteins in this family are typically between 392 and 442 amino acids in length.
Mitochondria-eating protein, C-terminal domain (MIEAP_C)
Type: Domain

This domain is found at the C terminus of mitochondria-eating proteins. Proteins containing this domain regulate mitochondrial quality. They have a role in damaged mitochondrial protein degradation and in damaged mitochondria degradation .
Type IV pilus non-core minor pilin PilE-like (PilE-like)
Type: Family

This entry represents the type IV pilus non-core minor pilin PilE. It is an essential component of the type IV pilus (T4P) that plays a role in surface and host cell adhesion, colonization, biofilm maturation, virulence, and twitching, a form of surface-associated motility facilitated by cycles of extension, adhesion, and retraction of T4P fibers .
Protein of unknown function DUF4786 (DUF4786)
Type: Family

This family of proteins is functionally uncharacterised. Proteins in this family are typically between 209 and 353 amino acids in length.
Solute carrier family 3 member 2, N-terminal domain (SLC3A2_N)
Type: Domain

Heteromeric amino acid transporters (HATs) are composed of two subunits, a heavy (SLC3 family) and a light subunit [SLC7 or L-type amino acid transporter (LAT) family] linked by a conserved disulfide bridge . HATs are amino acid exchangers, and the transport activity resides in the light subunit. The heavy chain of the surface antigen 4F2 (4F2hc), also known as amino acid transporter heavy chain SLC3A2, is a HAT heavy subunit . 4F2hc controls the cell surface expression as well as the membrane topology of the 4F2 heterodimer .

SLC3A2 is essential for plasma membrane localization, stability, and the transport activity of SLC7A5 and SLC7A8 . It forms heterodimers with SLC7 family transporters (SLC7A5, SLC7A6, SLC7A7, SLC7A8, SLC7A10 and SLC7A11), a group of amino-acid antiporters . The heterodimer with SLC7A11 functions as an antiporter by mediating the exchange of extracellular anionic L-cystine and intracellular L-glutamate across the cellular plasma membrane .

This entry represents the N-terminal domain of SLC3A2.
Protein of unknown function DUF4787 (DUF4787)
Type: Family

This presumed protein family is functionally uncharacterised. It is found in eukaryotes, and is approximately 70 amino acids in length.
Serine protease gd, N-terminal domain (GD_N)
Type: Domain

This domain is found at the N terminus of the serine protease GD (gastrulation defective) in insects . GD functions in the establishment of embryonic polarity .
Trypanosoma glutamic acid/alanine-rich protein (GARP)
Type: Domain

GARP, or glutamic acid/alanine-rich protein, is one of a subset of major surface molecules on Trypanosoma species. They are all surface-orientated, immunodominant, and highly charged. GARP is interesting as its expression coincides with the loss and gain of variant surface glycoprotein (VSG) molecules in the tsetse vector. It has an extended helical bundle structure that is homologous to the core surface structure of VSG, suggesting that it might replace the bloodstream VSG as the trypanosomes differentiate inside the tsetse vector after a blood-meal .
DNA primase DnaG, C-terminal helicase-binding domain (DnaG_HBD)
Type: Domain

This entry represents the C-terminal domain of the eubacterial primase DnaG, which is a single-stranded DNA (ssDNA)-dependent RNA polymerase responsible for the synthesis of oligonucleotide primers needed for DNA replication. This domain interacts with helicase at the replication fork .
Domain of unknown function DUF5067 (DUF5067)
Type: Domain

The function of DUF5067 is not clear.
Protein of unknown function DUF5066 (DUF5066)
Type: Family

The function of DUF5066 is not clear.
DNA repair protein Rev1, C-terminal (Rev1_C)
Type: Domain

This entry represents the C-terminal domain of DNA repair protein Rev1, an enzyme which allows DNA synthesis to proceed even in the presence of DNA damage. Rev1 belongs to the Y-family of TLS polymerases. Rev1 possess a limited catalytic activity but it has a second and more important function which involved the recruitment and coordination of other Y-family TLS polymerases and the regulatory subunit Rev7 of the B-family polymerase pol. This interaction is mediated by its C-terminal domain which therefore serves as a scaffold that allows access of the Y-family polymerases to their cognate DNA lesions and the subsequent exchange to pol, which then extends the distorted DNA primer terminus opposite the lesion . This domain adopts a four-helix bundle that interacts with Rev7, Polkappa and Poleta. However, the Rev7-binding interface is distinct from the binding site of DNA polymerase eta or kappa .
Domain of unknown function DUF4788 (DUF4788)
Type: Domain

This presumed domain is functionally uncharacterised. It is found in proteins from insects, and is approximately 230 amino acids in length. There is a single completely conserved residue D that may be functionally important.
Domain of unknown function DUF4789 (DUF4789)
Type: Domain

This presumed domain is functionally uncharacterised. This domain is found in arthropods, and is typically between 87 and 100 amino acids in length. There is a conserved GPC sequence motif. There are two completely conserved C residues that may be functionally important.
Janus kinase and microtubule-interacting protein, C-terminal domain (JAKMIP_C)
Type: Domain

This domain is found at the C terminus of proteins belonging to the JAKMIP family (Janus kinase and microtubule-interacting proteins) and is predicted to be a coiled coil. It interacts with the Janus family kinases Tyk2 and Jak1 .
Inositol polyphosphate 5-phosphatase, clathrin binding domain (OCRL_clath-bd)
Type: Domain

This domain is a clathrin binding domain found at the N terminus of inositol polyphosphate 5-phosphatase OCRL. It has a PH domain-like fold .
NVL2, nucleolin binding domain (NVL2_nucleolin-bd)
Type: Domain

This entry represents a domain found at the N terminus of nuclear valosin-containing protein (VCP)-like protein 2 (NVL2). This domain adopts a three helix fold resembling part of a winged helix motif and binds to nucleolin, a multifunctional phosphoprotein ubiquitously distributed in the nucleolus, nucleus and cytoplasm of the cell .
Myoviridae tail sheath stabiliser (T4-gp15_tss)
Type: Family

This entry represents the gp15 protein, which is the tail-sheath-stabiliser or tail-terminator protein of T4-like myoviridae phage. It forms a hexamer and attaches to the top of the phage tail stabilising the contractile sheath and forming the interface for binding of the independently assembled head . The gp15 hexamer interacts with the gp3 hexamer and, presumably, with the C-terminal domains of gp18 molecules located in the last ring of the contractile sheath. It also creates the binding site for attachment of the capsid with mutant phage tails lacking gp15 being unable to join the heads. The tail binds to the head via interactions of gp15 with gp14 (or with both gp13 and gp14) since the latter form a complex that seals the portal vertex and creates an attachment site of the independently assembled tail .
Protein of unknown function DUF5065 (DUF5065)
Type: Family

This family is found in found in Bacillus species. The function is not known.
Pathogenicity island protein gp6, Staphylococcus (SAPIS-gp6)
Type: Family

Gp6, a Staphylococcus aureus pathogenicity island 1 protein, is a mobile genetic element that carries genes for several superantigen toxins. It is a dimeric protein produced from the pathogenicity island with a helix-loop-helix motif similar to that of bacteriophage scaffolding proteins. It is thought to determine the size of the capsids of distribution of the SAPI1 genome as it acts as an internal scaffolding protein during capsid size determination .
Albumin I chain a (Albumin_I_a)
Type: Domain

The albumin I protein, a hormone-like peptide, stimulates kinase activity upon binding a membrane bound 43kDa receptor . It is cleaved into two chains; this domain represents the "a" chain.
SAWADEE domain (SAWADEE_dom)
Type: Domain

The SAWADEE domain, found in plant homeobox proteins SHH1 and SHH2, has a tudor-like fold and binds chromatin . SHH1 protein is involved in RNA-directed DNA methylation (RdDM) .
Immunity factor for SPN (IFS)
Type: Family

Immunity factor for SPN (IFS) binds to and inhibits the SPN toxin. IFS inhibits SPN enzymatic activity by binding over the active site and completely blocking its access to beta-NAD+ .
Ribosome-associated complex head domain (RAC_head)
Type: Domain

The ribosome-associated complex (RAC) head domain is involved in ribosome binding . It can be found at the C terminus of the yeast Zuotin (Zuo1) protein. Zuo1 is a component of RAC, a stable ribosome-associated heterodimer that functions as a chaperone at the ribosome .
Protein of unknown function DUF4790 (DUF4790)
Type: Family

This family of proteins is functionally uncharacterised. This family of proteins is found in insects. Proteins in this family are typically between 134 and 191 amino acids in length. There is a single completely conserved residue C that may be functionally important.
Tyrosyl-tRNA synthetase, C-terminal (TyrRSs_C)
Type: Domain

This domain is found at the C terminus of fungal mitochondrial tyrosyl-tRNA synthetases (mt TyrRS; CYT-18 protein), which are bifunctional proteins that both aminoacylate mitochondrial tRNA-Tyr and promote the splicing of mitochondrial group I introns. This C-terminal domain has been found to bind to group I intron RNAs .
Transmembrane inner ear expressed protein (TMIE)
Type: Family

This family of proteins includes the mammalian transmembrane inner ear expressed protein. Its function is unknown .
Protein of unknown function DUF4791 (DUF4791)
Type: Family

This family of insect proteins is functionally uncharacterised. Proteins in this family are typically between 189 and 203 amino acids in length. There are two conserved sequence motifs: PLPL and LGN. There is a single completely conserved residue N that may be functionally important.
E3 ubiquitin-protein ligase APD1-4, N-terminal (APD1-4_N)
Type: Domain

This domain is functionally uncharacterised, found towards the N-terminal of APD1-4 and in uncharacterised sequences, mainly found in plants and arthropods.

This entry includes E3 ubiquitin-protein ligase APD1 to 4 from Arabidopsis. They are involved in pollen mitosis II (PMII) regulation during male gametogenesis .
Stomatal closure-related actin-binding protein, coiled-coil domain (SCAB_CC)
Type: Domain

This entry represents the two coiled-coil dimerisation domains of plant-specific actin-binding proteins or SCABs, CC1 and CC2, both of which contribute independently to dimerisation. CC1 is also required for actin binding, indicating that SCAB1 is a bivalent actin cross-linker, since CC1 adopts an antiparallel helical hairpin that further dimerises into a four-helix bundle. SCAB proteins bind, bundle and stabilise actin filaments and regulate stomatal movement .
E3 ubiquitin-protein ligase APD1-4, middle domain (APD1-4_M)
Type: Domain

This domain is functionally uncharacterised, found in the middle of APD1-4 and in uncharacterised sequences, mainly found in plants and arthropods. There are two completely conserved C residues that may be functionally important.

This entry includes E3 ubiquitin-protein ligase APD1 to 4 from Arabidopsis. They are involved in pollen mitosis II (PMII) regulation during male gametogenesis .
Domain of unknown function DUF4794 (DUF4794)
Type: Domain

This presumed domain is functionally uncharacterised. It is found in insect proteins, and is typically between 74 and 92 amino acids in length.