SII-SWORD/CoKE huggingface dataset:
Protein of unknown function DUF7185 (DUF7185)
Type: Family

This entry represents an uncharacterised protein found in various mycobacteriophages. The protein is typically around 80 to 100 amino acids in length. It is found in phages belonging to cluster B, such as the Bclasvirinae and Coopervirus genera. The function of this protein is currently unknown.
Protein of unknown function DUF7186 (DUF7186)
Type: Family

This entry represents a small transmembrane protein found in Lactococcus 936-type phages. The function of this protein is unknown. It contains a single transmembrane helix.
Protein of unknown function DUF7187 (DUF7187)
Type: Family

This entry represents a family of small proteins of around 60 residues found in Omarvirus and related bacteriophages that infect Streptomyces species. The function of this protein family is currently unknown. Homologous proteins are also found in a small number of Streptomyces genomes. The AlphaFold model of

shows a pair of α helices at the C terminus of the protein.
Protein of unknown function DUF7188 (DUF7188)
Type: Family

This entry represents an uncharacterised protein of around 185-188 amino acids found in phages that infect Cutibacterium and Propionibacterium species. The function of this protein is currently unknown.
Protein of unknown function DUF7189 (DUF7189)
Type: Family

This entry represents an uncharacterised protein of approximately 60-70 amino acids that is found in various phages, predominantly phages that infect members of the Enterobacteriaceae family such as Escherichia, Shigella, and Klebsiella.
Protein of unknown function DUF7190 (DUF7190)
Type: Family

This entry represents a putative membrane protein found in several mycobacteriophages, especially those belonging to the genus Cheoctovirus. The function is unknown. Most members contain a predicted transmembrane helix near the N terminus. The family shows some length variation, especially at the C terminus.
Protein of unknown function DUF7191 (DUF7191)
Type: Family

This family of uncharacterised proteins is found in viruses, primarily cyanophages that infect cyanobacteria such as Synechococcus and Prochlorococcus species. The family contains short sequences, generally between 45-50 amino acid residues in length. No functional information is available for members of this family.
Domain of unknown function DUF7192 (DUF7192)
Type: Domain

This entry represents a bacterial domain of unknown function. The domain is around 270 to 300 amino acids in length. It is found in a variety of bacterial phyla including Actinobacteria, Bacteroidota, Pseudomonadota and Verrucomicrobiota. The domain is also found in some bacterial phages. The function of this domain is unknown. The structure of this domain shows similarity to VWFA domains.
Protein of unknown function DUF7193 (DUF7193)
Type: Family

This entry represents a family of viral proteins that are found in various bacteriophages infecting Gram-negative bacteria, such as Pseudomonas, Vibrio, Erwinia, Ralstonia, and Klebsiella. The family members are typically 800-1200 residues in length. Many are annotated as putative virion structural proteins, suggesting they may play a role in phage particle structure or assembly. However, the precise function of this family remains unknown.
Protein of unknown function DUF7194 (DUF7194)
Type: Family

This entry represents an uncharacterised protein family found in viruses from the order Caudoviricetes. The family contains proteins between 199 and 219 amino acids in length. The function of this family is currently unknown.
Protein of unknown function DUF7195 (DUF7195)
Type: Family

This entry represents a family of uncharacterised bacteriophage proteins, typically around 70-80 amino acids in length. They are found in phages infecting Escherichia, Pseudomonas, Salmonella, Vibrio, and other bacterial hosts.
Domain of unknown function DUF7196 (DUF7196)
Type: Domain

This entry represents an uncharacterised protein domain found in viruses and bacteria, including Mycobacteriophages, Nocardia, Streptomyces and Rhodococcus species. The domain is typically between 50-99 amino acids in length. In some proteins, the domain is found at the C terminus. AlphaFold prediction shows a small domain composed of three β-strands in a sheet with a single α-helix between strands 2 and 3.
Protein of unknown function DUF7197 (DUF7197)
Type: Family

This entry represents a domain of unknown function. It is typically between 120 and 250 amino acids in length.
Protein of unknown function DUF7198 (DUF7198)
Type: Family

This entry represents a family of putative phage membrane proteins. It is characterised by a single transmembrane helix at the N-terminal that likely serves to anchor these proteins to the membrane. The exact functions of the proteins containing this domain remain unknown.
Protein of unknown function DUF7199 (DUF7199)
Type: Family

This family consists of several mycobacteriophage putative membrane proteins of around 99 amino acids in length. These proteins are characterised by an N-terminal transmembrane helix, a small central putative zinc binding domain containing 2 conserved cysteine and 2 histidine residues and disordered C-terminal region rich in basic and acidic residues.
Protein of unknown function DUF7200 (DUF7200)
Type: Family

This entry represents an uncharacterised protein found in various phages that infect bacteria including Escherichia, Salmonella, Shigella, Klebsiella, Enterobacter, Citrobacter and Cronobacter. The protein ranges in length from around 66 to 98 amino acids. The protein forms a single compact domain composed of a four stranded β sheet and two α helices. The structure shows some weak structural similarity to the BRICHOS domain. No clear function is known for these proteins.
Domain of unknown function DUF7201 (DUF7201)
Type: Domain

This entry includes a family of phage proteins found to be associated with membranes, based on transmembrane region predictions. They are typically around 110 amino acids in length with a C-terminal membrane helix. Many also contain predicted coiled-coil region spanning the rest of the protein. The specific function is unknown. However, it could play a role in membrane fusion.
Domain of unknown function DUF7202 (DUF7202)
Type: Domain

This entry describes a domain of unknown function (DUF). It is found in phage proteins, generally around 70 amino acids in length. The domain is found in a variety of phages infecting hosts such as Escherichia, Shigella, Yersinia, Erwinia, Providencia, and Pectobacterium. No functional information is known. An AlphaFold model shows this protein adopts a three stranded β sheet structure.
Protein of unknown function DUF7203 (DUF7203)
Type: Family

These proteins are found in various phages infecting bacteria from the Enterobacteriaceae family, such as Escherichia, Salmonella, Shigella, Klebsiella, and Yersinia. They are typically around 100 amino acids in length.
Domain of unknown function DUF7204 (DUF7204)
Type: Domain

This domain family is found in viruses that infect Streptococcus thermophilus bacteria. All members are from Caudoviricetes viruses. The domain is approximately 50 amino acids in length. The function of this domain is currently unknown. An AlphaFold model shows these proteins adopt a compact domain composed of a three stranded β sheet with a single α helix.
Protein of unknown function DUF7205 (DUF7205)
Type: Family

This entry represents a family of phage proteins that adopt a small β barrel-like fold. The family is found in phages infecting members of the Enterobacteriaceae, such as Escherichia, Salmonella, Klebsiella, Cronobacter, Citrobacter, Erwinia, and Pectobacterium. The exact function of this protein within the phage tail is unknown. The family shows a highly conserved length of around 60-75 amino acids, with a few members having N- or C-terminal extensions.
Protein of unknown function DUF7206 (DUF7206)
Type: Family

This entry represents a family of uncharacterised phage proteins including from bacteriophage T6.
Protein of unknown function DUF7207 (DUF7207)
Type: Family

This entry represents an uncharacterised protein found in various bacteriophages that infect cyanobacteria and other bacterial hosts. The protein ranges in length from approximately 75 to 136 amino acids.
Protein of unknown function DUF7208 (DUF7208)
Type: Family

This entry represents a domain of unknown function found in large phage virion structural proteins. The domain is approximately 290 to 330 amino acids in length. It is found in a variety of phage proteins infecting bacterial hosts such as Pseudomonas, Vibrio, Ralstonia, and Erwinia, among others.
Protein of unknown function DUF7209 (DUF7209)
Type: Family

This entry represents a component of the virion particle in several bacteriophages infecting hosts such as Bacillus, Staphylococcus, Listeria, Enterococcus and Lactobacillus, including Virion protein 6 from Enterococcus phage phiEF24C. The exact function is unknown but it is likely to play a structural role.
Domain of unknown function DUF7210 (DUF7210)
Type: Domain

This entry represents a small domain found in a variety of uncharacterised phage proteins.
DUF7211 (DUF7211)
Type: Conserved_site

This entry represents a short highly motif that is found in some phage proteins, usually at the N-terminal. The function of this motif is unknown.
Protein of unknown function DUF7212 (DUF7212)
Type: Family

This entry represents a small phage protein that is composed of two α helices. According to AlphaFold prediction this protein forms a confident head to tail oriented dimer, forming a four helix bundle. The function of these proteins is unknown.
Protein of unknown function DUF7213 (DUF7213)
Type: Family

This entry represents an uncharacterised protein of approximately 70-100 amino acids found in mycobacteriophages. The function of this protein is currently unknown. It is found in phages belonging to the Gracegardnervirinae subfamily, including Cheoctovirus and Terapinvirus genera. This protein forms a confident dimer according to an AlphaFold model of

. The dimer forms a central four stranded β sheet with two α helices packed orthogonally to the direction of the β strands on each face of the sheet.
Protein of unknown function DUF7214 (DUF7214)
Type: Family

This entry represents a phage protein of unknown function. According to AlphaFold models the domain forms a four stranded β sheet followed by a single α helix. This domain forms a confident dimer according to AlphaFold.
Protein of unknown function DUF7215 (DUF7215)
Type: Family

This entry represents a domain of unknown function found in phage proteins, typically 45-60 amino acids in length. It is found in Streptomyces phages of the Caudoviricetes order, primarily in the Arquatrovirinae subfamily. The domain does not contain any conserved motifs or residues that provide hints about its function. A structure prediction shows that it is composed of two non-interacting α helices.
Protein of unknown function DUF7216 (DUF7216)
Type: Family

This entry represents a family of cyanophage proteins, including Gp130, that are found in a variety of Synechococcus and Prochlorococcus phages. The family members are typically around 100 amino acids in length. Structure predictions do not show a globular fold for this protein. The exact function of this family is unknown.
Domain of unknown function DUF7217 (DUF7217)
Type: Domain

This entry represents an uncharacterised protein domain found in phage and bacterial proteins.
Protein of unknown function DUF7218 (DUF7218)
Type: Family

This entry represents a small conserved sequence region found in a variety of largely mycobacterial phage proteins as well as bacterial proteins. It is often found N-terminal to

.
Protein of unknown function DUF7219 (DUF7219)
Type: Family

This entry represents a domain of unknown function. The domain is found in bacteria, primarily in cyanobacteria and their phage. It is typically around 80-90 amino acids in length. AlphaFold prediction suggests this protein is composed of two longer paired α helices followed by a shorter third helix.
Protein of unknown function DUF7220 (DUF7220)
Type: Family

This short protein is found among some phage. It is possibly distantly related to the small terminase family

.
DeoxyPurine in DNA protein A (DpdA)
Type: Domain

This entry, previously known as DUF7221, represents the DpdA family of proteins, which are involved in the insertion of deazapurine modifications in bacterial and phage DNA. DpdA proteins are paralogues of tRNA-guanine transglycosylases (TGT), but have evolved to act on DNA rather than RNA. They catalyze the incorporation of 7-deazaguanine derivatives such as dADG (7-amido-7- deazaguanine) and dpreQ0 (7-cyano-7-deazaguanine) into DNA, which is thought to function as a protection mechanism against endonucleases. The dpdA gene is typically part of a genomic island, along with dpdB, dpdC and dpdD genes, and is proposed to be part of a restriction/ modification system that protects bacteria from foreign DNA .
Domain of unknown function DUF7222 (DUF7222)
Type: Domain

This entry represents a family of uncharacterised proteins found in various cyanophages, bacteriophages and bacteria species. The domain is approximately 100-160 amino acids in length. Structure prediction shows this domain is α helical.
Domain of unknown function DUF7223 (DUF7223)
Type: Domain

This domain is found in uncharacterised proteins mainly from fungi. It is frequently found associated with

. This domain is predicted to adopt a globular structure with an elongated β-sandwich topology.
Domain of unknown function DUF7224 (DUF7224)
Type: Domain

This entry represents a metalloprotease-like domain found in ABC transporter permease from bacteria, predominantly Streptomyces spp. The function of this domain is unknown.
Domain of unknown function DUF7225 (DUF7225)
Type: Domain

This domain is found in uncharacterised protein YnaC and related bacterial proteins. It is usually associated with (

). This domain is a winged helix (WH) domain decorated at the C terminus with a small three stranded β-sheet that packs on the WH domain to form a single globular structure.
Domain of unknown function DUF7226 (DUF7226)
Type: Domain

This domain is found in uncharacterised proteins. It is usually found in combination with

and

. It is predicted to contain a winged helix (WH) domain that is flanked at the C terminus with a small helical subdomain. The latter packs on the WH domain to form a compact globular structure.
Domain of unknown function DUF7227 (DUF7227)
Type: Domain

This domain of unknown function is found in various phage and bacterial proteins. The domain length ranges from approximately 200 to 260 amino acids.
Protein of unknown function DUF7228 (DUF7228)
Type: Family

This family of uncharacterised proteins is found in several Lactococcus phages. All members are short proteins, between 33-59 amino acids in length. The family shows some conserved polar residues at the N-terminal. These proteins appear to be disordered.
Domain of unknown function DUF7229 (DUF7229)
Type: Domain

This small helical domain is found a small family of phage proteins.
Protein of unknown function DUF7230 (DUF7230)
Type: Family

This entry represents a family of uncharacterised proteins found in phage and bacterial species, particularly in the Gammaproteobacteria class. Members of this family are typically short proteins, ranging from 32 to 85 amino acids in length. Many members are predicted to contain disordered regions and AlphaFold predictions show a non-globular structure.
Protein of unknown function DUF7231 (DUF7231)
Type: Family

This entry represents a family of unknown function found in phage proteins, typically 120-130 amino acids in length. Some members contain a C-terminal region enriched in basic residues that is predicted to be disordered. The N-terminal of the proteins contain a small globular domain. These proteins are found in the Ackermannviridae family of phages that infect Enterobacteria such as Salmonella, Escherichia, Shigella, and Dickeya.
Protein of unknown function DUF7232 (DUF7232)
Type: Family

This entry represents an uncharacterised phage family. A structure prediction suggests that the proteins consist of a three stranded β meander followed by a C-terminal α helix.
Domain of unknown function DUF7233 (DUF7233)
Type: Domain

This domain is found in the phages infecting Mycobacterium and Gordonia. The domain is around 70-100 amino acids long.
Protein of unknown function DUF7234 (DUF7234)
Type: Family

This family represents a domain of unknown function, which is found in phage proteins ranging in length from 75 to 88 amino acids. The domain is found in phage that infect Salmonella, Shigella, Serratia, and Enterobacter species.
Protein of unknown function DUF7235 (DUF7235)
Type: Family

This entry represents an uncharacterised protein found in various phages that infect bacteria. The function of this protein is currently unknown. It is typically around 300-340 amino acids in length. This protein contains a predicted coiled-coil region near its C-terminal.
Protein of unknown function DUF7236 (DUF7236)
Type: Family

This entry represents a family of uncharacterised mycobacterium phage proteins.
Protein of unknown function DUF7237 (DUF7237)
Type: Family

This entry represents a protein of unknown function found in phage proteins. The domain contains approximately 77 residues and may contain a single transmembrane helix near the N terminus.
Protein of unknown function DUF7238 (DUF7238)
Type: Family

This entry represents a domain of unknown function. It is found in uncharacterised phage proteins in the size range 90 to 120 amino acids. The domain does not appear to be related to any other known domain. The function of this domain remains to be determined.
Protein of unknown function DUF7239 (DUF7239)
Type: Family

This entry reprepsents a family of uncharacterised proteins found in mycobacterial phage.
Protein of unknown function DUF7240 (DUF7240)
Type: Family

This protein is found in uncharacterised proteins from various mycobacteriophages and bacterial species including Nocardia and Mycobacterium. The protein is typically around 100 amino acids in length.
Domain of unknown function DUF7241 (DUF7241)
Type: Domain

This entry represents a family of small phage proteins found in a variety of mycobacteriophage genomes. The family members are typically around 70-75 amino acids in length. The function of these proteins is currently unknown.
Protein of unknown function DUF7242 (DUF7242)
Type: Family

This entry represents a family of uncharacterised phage proteins. AlphaFold multimer suggests this protein may form a dimeric ring arrangement.
Protein of unknown function DUF7243 (DUF7243)
Type: Family

This family of phage proteins adopt a structure composed of a pair of jelly roll fold domains with one nested within the other. This fold is suggestive of a phage head structural protein. Structure predictions suggest that these proteins can form pentameric or hexameric arrangements mediated by the outer of the two domains.
Domain of unknown function DUF7244 (DUF7244)
Type: Domain

This entry represents an uncharacterised protein found in various bacteriophages that infect bacteria in the family Enterobacteriaceae, including phages of Escherichia, Shigella and Citrobacter. The protein is approximately 55-60 amino acids in length. An AlphaFold model shows this domain adopts a small β barrel structure. This domain is possibly related to the KOW motif.
Protein of unknown function DUF7245 (DUF7245)
Type: Family

This entry represents an uncharacterised protein domain found in viral proteins, primarily from Mycobacterium and Gordonia phages. The domain is approximately 120 amino acids in length. These proteins are composed of a small N-terminal zinc binding domain connected by an α-helix to a small β-barrel domain at the C-terminal.
Domain of unknown function DUF7246 (DUF7246)
Type: Domain

This entry describes a domain of unknown function found in phage proteins. The proteins containing this domain average 90 to 100 amino acids in length and is found in a variety of phage proteins, particularly those from Streptomyces and Mycobacterium phages. The domain usually occurs near the middle or C-terminal of proteins. The domain forms a small β-barrel.
Domain of unknown function DUF7247 (DUF7247)
Type: Domain

This entry represents an uncharacterised phage domain composed of a seven stranded β sheet with a C-terminal α helix. Structure prediction suggests this protein may form a homodimer.
Protein of unknown function DUF7248 (DUF7248)
Type: Family

This entry represents a small family of uncharacterised phage proteins that have a single transmembrane helix followed by a conserved C-terminal sequence. The family includes proteins from phage T4 and T6.
Protein of unknown function DUF7249 (DUF7249)
Type: Family

This family represents an uncharacterised protein domain found in phage proteins, mostly from Caudovirales. The domain is around 70-120 amino acids in length.
Domain of unknown function DUF7250 (DUF7250)
Type: Domain

This entry represents a domain of unknown function found in phage proteins, approximately 100 residues in length. The domain is found in Microbacterium phages.
Protein of unknown function DUF7251 (DUF7251)
Type: Family

This entry represents a family of protein of unknown function found in phage. The proteinσ are predicted to be largely disordered, with a C-terminal small β barrel domain.
Domain of unknown function DUF7252 (DUF7252)
Type: Domain

This entry represents a domain of unknown function found in bacteriophage proteins. The domain is around 115-125 residues long composed of a four stranded β sheet with helices packed on one side. There is evidence for a confident dimer from structure prediction. In addition the dimer shows a strong electrostatic polarity possibly suggesting a nucleic acid binding function.
Domain of unknown function DUF7253 (DUF7253)
Type: Domain

This entry represents a domain of unknown function, which is found in phage proteins, predominantly from Arthrobacter and Gordonia phages. The domain is approximately 110 amino acids in length. It shows similarity to the Phage_barrel superfamily. These proteins are often components of the phage neck complex.
Domain of unknown function DUF7254 (DUF7254)
Type: Domain

This entry represents a small family of uncharacterised phage proteins that adopt a compact domain composed of a four stranded β sheet followed by two α helices packed on one side of the sheet.
Protein of unknown function DUF7255 (DUF7255)
Type: Family

This entry represents uncharacterised bacterial proteins that were predicted to possess defence functions . They contain highly conserved aspartate and histidine residues that may have functional role.
Domain of unknown function DUF7256 (DUF7256)
Type: Domain

This entry represents a domain found in uncharacterised proteins from proteobacteria. This domain is sometimes found N-terminal to

.
Domain of unknown function DUF7257 (DUF7257)
Type: Domain

This entry represents a phage protein which contains a C1q and TNF superfamily domain. Structure prediction suggests that this domain forms a confident homotrimeric interaction.
Domain of unknown function DUF7258 (DUF7258)
Type: Domain

This domain is found in uncharacterised proteins from Bacteroidota. It is predicted to adopt a globular structure with SH3-like topology. It is sometimes found N-terminal to

.
Domain of unknown function DUF7259 (DUF7259)
Type: Domain

This domain is found in uncharacterised proteins from proteobacteria. It is usually found C-terminal to

. It is predicted to adopt a globular structure with a β-barrel shape.
Domain of unknown function DUF7260 (DUF7260)
Type: Domain

This domain is found in uncharacterised proteins from Halobacteria. It is predicted to adopt a globular structure composed mainly of α-helices.
Protein of unknown function DUF7261 (DUF7261)
Type: Family

This entry represents uncharacterised proteins found mainly in Halobacteria.
Protein of unknown function DUF7262 (DUF7262)
Type: Family

This entry represents uncharacterised proteins found mainly in Halobacteria. They are composed of N-terminal transmembrane helix and alpha/beta globular domain.