SII-SWORD/CoKE huggingface dataset:
Putative acetyl-transferase (Acetyltransf_15)
Type: Family

This is a family of microsporidial proteins which may be distantly related to acetyl-transferase .
Armadillo-like helical domain-containing protein 4 (ARMH4)
Type: Family

The function of ARMH4 is not clear.
Coiled-coil domain-containing protein 190 (CC190)
Type: Family

This family of proteins is found in eukaryotes. Proteins in this family are typically between 234 and 297 amino acids in length.
Protein of unknown function DUF4698 (DUF4698)
Type: Family

This family of proteins is found in eukaryotes. They are also known as coiled-coil domain-containing protein 60. Proteins in this family are typically between 464 and 550 amino acids in length.
Protein of unknown function DUF5091 (DUF5091)
Type: Family

This is a group of microsporidial-specific proteins with unknown function.
PDCD10 and GCKIII kinases-associated protein 1 C4orf19/PGCKA1 (C4orf19)
Type: Family

This entry describes PDCD10 and GCKIII kinases-associated protein 1 C4orf19 (PGCKA1) proteins found in animals. C4orf19 is a member of the programmed cell death 10 (PDCD10)-germinal center kinase III (GCKIII) module, which is predicted to be located at the cell periphery . The function of C4orf19 (ex DUF4699) has been recently characterised. It was shown that it acts as a tumor suppressor for CRC cell proliferation by targeting the Keap1/USP17/Elk-1/CDK6 axis .
Interactor of HORMAD1 protein 1 (IHO1)
Type: Family

Interactor of HORMAD1 protein 1 (IHO1, previously known as coiled-coil domain-containing protein 36 or DUF4700) is required for DNA double-strand breaks (DSBs) formation in unsynapsed regions during meiotic recombination. It is thought to function, in collaboration with SPO11-auxiliary proteins MEI4 and REC114, through the formation of DSB-promoting recombinosomes on chromatin at the onset of meiosis .
UPF0688 family (UPF0688)
Type: Family

This family of proteins is found in eukaryotes. Proteins in this family are typically between 176 and 243 amino acids in length.
Dynein axonemal assembly factor 8 (DNAAF8)
Type: Family

DNAAF8 is a axonemal dynein regulator that interacts with outer dynein arm (ODA) subunits and is required for deployment of ODA to the axoneme .
Protein of unknown function DUF4702 (DUF4702)
Type: Family

This family of proteins is found in eukaryotes. Proteins in this family are typically between 346 and 637 amino acids in length.
Protein of unknown function DUF5093 (DUF5093)
Type: Family

This entry represents a group of microsporidial sequences that may be distantly related to Ribosomal RNA-processing protein 7 (

).
Sperm acrosome developmental regulator (SPACDR)
Type: Family

This family may play a role in acrosome formation and nucleus shaping during spermiogenesis .
Proline-rich protein 22 (PRR22)
Type: Family

This family of proteins is found in eukaryotes. Proteins in this family are typically between 217 and 420 amino acids in length.
Protein of unknown function DUF5092 (DUF5092)
Type: Family

This entry represent a group of largely microsporidial sequences with unknown function. There is one transmembrane domain towards the C terminus.
Tryptophan RNA-binding attenuator protein inhibitory protein (Anti-TRAP)
Type: Family

Tryptophan RNA-binding attenuator protein (TRAP) inhibitory protein, also known as anti-TRAP (AT), recognises the tryptophan-activated RNA-binding domain of TRAP, a protein that regulates expression of genes involved in tryptophan metabolism in response to the accumulation of l-tryptophan . Anti-TRAP relieves TRAP-mediated repression of the trp operon expression by binding directly to Trp-bound activated TRAP and excluding RNA binding .
Protein of unknown function DUF5090 (DUF5090)
Type: Family

This is a microsporidial-specific family of proteins with unknown function. The family is likely to have four transmembrane domains.
Protein of unknown function DUF5088 (DUF5088)
Type: Family

This is a family of microsporidial sequences of unknown function.
HTH-like domain-containing protein, Microsporidia (HTH_micro)
Type: Family

This entry represents a group of microsporidial proteins whose function is not known. It is possible that they are DNA-binding as there is distant homology to helix-turn-helix domain containing proteins .
Cation channel complex component UNC80, N-terminal (UNC80_N)
Type: Domain

UNC80 is a protein associated with the NALCN sodium channel complex, and is required for the activation of this channel by the neuropeptide substance P. NALCN activation is G-protein-independent, but requires Src kinases. NUNC80 binds Src kinases and recruits Src into the channel complex . UNC80 is required for the proper localisation of C. elegans NCA-1 and NCA-2, the homologues of the vertebrate cation leak channel NALCN . NCA-1 and UNC-80 regulate neuronal activity in C. elegans .

This entry represents the N-terminal domain of UNC80.
Protein of unknown function DUF5087 (DUF5087)
Type: Family

This is a family of microsporidial sequences of unknown function.
WD40-like domain containing protein (WD40-like)
Type: Family

This is a family of proteins which have weak homology to the WD40 repeat family. Members are largely from microsporidia .
Signal recognition particle subunit SRP72, TPR-like repeat (SRP72_TPR-like)
Type: Repeat

This entry represents a TPR-like repeats found in a group of eukaryotic proteins, including signal recognition particle subunit SRP72, a component of the signal recognition particle (SRP) complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER) . This protein binds the signal recognition particle RNA (7SL RNA) in presence of SRP68 .
Putative actin-like (Actin-like)
Type: Family

This entry includes a group of eukaryotic proteins, mainly found in microsporidia. The specific function of its members is unknown. There is distant homology to the Actin family .
Protein of unknown function DUF5089 (DUF5089)
Type: Family

This is a family of largely microsporidial-specific proteins of unknown function. There is distant homology to synaptosomal-associated 25 family proteins .
Accessory secretory protein Asp5 (Asp5)
Type: Family

Asp4 and Asp5 are putative accessory components of the SecY2 channel of the SecA2-SecY2 mediated export system, but they are not present in all SecA2-SecY2 systems . This family of Asp5 proteins is found in Streptococcus spp.
Abnormal spindle-like microcephaly-associated protein, ASH domain (ASH)
Type: Domain

The ASH (ASPM-SPD-2-Hydin) domain or N-terminal domain of abnormal spindle-like microcephaly-associated protein (ASPM) is found in proteins associated with cilia, flagella, the centrosome and the Golgi complex . The domain is also found in Hydin and OCRL whose deficiencies are associated with hydrocephalus and Lowe oculocerebrorenal syndrome (OCRL), respectively. The presence of ASH in centrosomal and ciliary proteins indicates that ASPM may possess roles not only in mitotic spindle regulation, but also in ciliary and flagellar function .
Rad61, Wapl domain (Rad61_Wapl)
Type: Domain

The Wapl domain is found at the C terminus of fungal Wpl1 proteins (also known as Rad61), which are subunits of a complex that inhibits sister chromatid cohesion. The Wapl domain binds to the ATPase domain of cohesin subunit Smc3 .
Accessory secretory protein Asp4 (Asp4)
Type: Family

Asp4 and Asp5 are putative accessory components of the SecY2 channel of the SecA2-SecY2 mediated export system, but they are not present in all SecA2-SecY2 systems . This family of Asp4 proteins is found in Streptococcus spp.
ParE-like toxin (ParE-like_toxin)
Type: Family

ParE is the toxin family of a type II toxin-antitoxin family. This family consists of proteins of unknown function related to ParE, but does not include ParE.
Lysyl-tRNA synthetase, N-terminal transmembrane region (tRNA-synt_2_TM)
Type: Domain

This entry represents the N-terminal region of tRNA-synthase-2, with 6xTMs. The presence of this region indicates that the protein is anchored in the membrane.
Fibrous sheath-interacting protein 2, C-terminal (FSIP2_C)
Type: Domain

This domain is the C-terminal portion of FSIP2, fibrous sheath-interacting protein 2, a protein found in mammals. The function is not known, but the domain appears to be repeated up to 10 times in some members.
DNA-directed RNA polymerase subunit Rpo8 (RNA_pol_Rpo8)
Type: Family

This is a family of archaeal DNA-directed RNA polymerase G subunits (RpoG/Rpo8) .
Sir4, SID domain (SIR4_SID)
Type: Domain

This is the Sir2 interaction domain (SID domain) of silent information regulator 4 (Sir4) . Sir4 is a silent information regulator (SIR) required for transcriptional repression of the silent mating type loci, HML and HMR. It also and helps maintain a repressed chromatin structure near telomeres .
N-CoR, GPS2-interacting domain (N-CoR_GPS2_interact)
Type: Domain

The G-protein pathway suppressor 2 (GPS2)-interacting domain is found in NCoR (nuclear receptor corepressor) proteins. NCoR1 and NCoR2 (also known as SMRT) are related corepressors that mediate transcriptional repression by unliganded nuclear receptors and other classes of transcriptional repressors. GPS2 is a stoichiometric subunit of the N-CoR-HDAC3 complex. GPS2 links the complex to membrane receptor-related intracellular JNK (c-Jun amino-terminal kinase) signalling pathways .
Vacuolar protein-sorting-associated protein 36, NZF-N zinc-finger domain (Vps36-NZF-N)
Type: Domain

This NZF-N zinc-finger domain of Vps36 protein interacts with the C terminus of vacuolar protein sorting 28 .
Serine/threonine-protein kinase SMG1 (SMG1)
Type: Family

Serine/threonine-protein kinase SMG1 is a phosphatidylinositol kinase-related protein that acts as an mRNA-surveillance protein and is a key component of nonsense-mediated decay (NMD) . In C.elegans, SMG1 is a key regulator of growth. Loss of SMG1 leads to hyperactive responses to injury and subsequent growth that continues out of control. It has an antagonistic role to mTOR signalling in worms and possibly also in higher eukaryotes.
Heavy-metal resistance protein CzcE (CzcE)
Type: Family

CzcE is involved in heavy-metal resistance . It binds copper , which induces a conformational change. It is thought that CzcE acts both as a Cu(I) and Cu(II) sensor and mediator of the multiple cross-responses of C. metallidurans CH34 against heavy metals by linking copper and cobalt-zinc-cadmium resistance .
Protein of unknown function DUF5086 (DUF5086)
Type: Family

This family includes uncharacterised proteins predominantly found in Proteobacteria, such as

from Pseudomonas aeruginosa. This protein folds into a five-stranded antiparallel β-sheet sandwiched between two short α-helices .
Molybdate transporter 1/2 (MOT1/MOT2)
Type: Family

This is a family of molybdenate transporters, including MOT1 and MOT2 from Arabidopsis. Molybdenum is an essential element that is taken up into the cell in the oxyanion molybdate. Molybdenum is used in the form of molybdopterin-cofactor, which participates in the active site of enzymes involved in key reactions of carbon, nitrogen, and sulfur metabolism .
Putative Flagellin, Flp1-like domain (Flp1-like)
Type: Domain

This entry represents the Flp1-like domain of putative Flagellin proteins.
T-superfamily conotoxin (T-conotoxin)
Type: Family

Conotoxins are Cone snail venom bioactive peptides. The T-superfamily of conotoxins includes two types of peptides, the T-1-conotoxins group (tau-conotoxin) and the T-2-conotoxin group (chi-conotoxin) . T-1-conotoxin Lt5d has been shown to inhibit voltage-gated sodium channels . Chi-conotoxins show a unique ability to highly selectively and non-competitively inhibit the noradrenaline transporter (NET/SLC6A2) . They show an unusual cysteine-stabilised scaffold that presents a γ-turn in an optimised conformation for high affinity interactions with the noradrenaline transporter .
Putative citrate transporter (CitMHS_2)
Type: Family

This is a family of putative citrate transporters, belonging to the Na+/H+ antiporter NhaD-like permease superfamily.
Sin1, middle CRIM domain (CRIM_dom)
Type: Domain

CRIM is a domain in the middle of Sin1 protein that is important in the substrate recognition of TORC2. It is conserved from yeast to humans. TOR is a serine/threonine-specific protein kinase and forms functionally distinct protein complexes referred to as TORC1 and TORC2 .
Protein Pet117, mitochondrial (Pet117)
Type: Family

Pet117 is a family of eukaryotic proteins found from fungi and plants to human. It is likely to be involved in the assembly of cytochrome C oxidase, and is found in the mitochondrion .
Apextrin, C-terminal domain (ApeC)
Type: Domain

The apextrin C-terminal domain (ApeC) was first identified from two apextrin-like proteins (ALP) of the amphioxus Branchiostoma japonicum. Amphioxus ALP1 and ALP2 are important anti-bacterial effectors. The apeC domain of the ALP1/2 mediates the bacterial recognition by binding to bacterial muramyl dipeptide (MDP). Further analysis shows that the apeC domain is present in various proteins from cnidarians, molluscs, arthropods, hemichordates, echinoderms and amphioxus. The apeC domain is also found to form different domain combinations with other domains .
Neurobeachin/BDCP, DUF4704 (NBEA/BDCP_DUF4704)
Type: Domain

This domain of unknown function is found in eukaryotes, on neurobeachin and BEACH domain-containing proteins (BDCPs) . Mutations in this proteins are associated with Lipopolysaccharide-responsive and beige-like anchor (LRBA) deficiency .
Flp pilus assembly protein RcpC/CpaB domain (RcpC_dom)
Type: Domain

This entry represents a domain found in the putative pilus assembly protein RcpC and RcpC-like protein CpaB. RcpC is a bacterial protein expressed from the tight-adherence tad locus. The Tad machine assembles type IVb pili, and RcpC could have a role modifying the Flp pilin . It is an auxiliary protein that sits in the inner membrane and interacts with TadB and TadZ, an AAA ATPase . A recent study has identified two tandem β-clip domains in RcpC95. β-Clip domains are known to interact with carbohydrate moieties in other systems .
Domain of unknown function DUF4705 (DUF4705)
Type: Domain

DUF4705 is a repeated domain found in eukaryotes. It can occur up to 10 times in any one sequence. The repeat is rich in glycine and proline residues.
GPI-anchored cell wall protein repeat (Cell_wall_rpt)
Type: Repeat

This repeat is found in cell wall proteins from fungi, including some members of the HYR/IFF families .
E1A-binding protein p400, N-terminal (EP400_N)
Type: Domain

This entry represents the N-terminal domain of EP400, a component of the NuA4 histone acetyltransferase complex that was first identified through its ability to bind the adenovirus E1A protein . The exact function of this domain is not known. This domain is largely low-complexity residues.
Flagellar motor switch protein FliN, N-terminal (FliN_N)
Type: Domain

This entry represents the N-terminal domain of FliN. FliN is one of three proteins that form a switch-complex at the base of the basal body of the flagellum; the switch regulates the flagellum-motor .
Doublesex- and mab-3-related transcription factor C1/C2, C-terminal (DMRT-C1/C2_C)
Type: Domain

The vertebrate DMRT (doublesex-and mab-3-related transcription factor) gene family encodes putative transcription factors related to the sexual regulators Doublesex (Drosophila melanogaster) and MAB-3 (Caenorhabditis elegans). They share a highly conserved DNA binding motif, the DM domain. This entry represents a domain found in the C-terminal of the DMRT C1 and C2 proteins. DMRTC1 (also known as DMRT8) is located on the X chromosome in placental mammals. It is related to DMRTC2 (DMRT7) but has lost the DM domain .
Na+ channel auxiliary subunit TipE (TipE)
Type: Family

TipE appears to be a family of insect Na+ channel auxiliary subunit proteins . It is required during pupal development to rescue adult paralysis and also protects adult flies against heat-induced lethality .
Rough colony protein B (RcpB)
Type: Family

RcpB is part of the tad operon of proteins . The Tad (tight adherence) macromolecular transport system, present in many bacterial and archaeal species, represents an ancient and major new subtype of type II secretion. The three Rcp proteins (RcpA, RcpB, and RcpC) and TadD, a putative lipoprotein, are localised to the bacterial outer membrane .
Pilus assembly protein TadZ, N-terminal (TadZ_N)
Type: Domain

This entry represents the N-terminal region of the Flp pilus assembly protein TadZ, which carries an AAA, ATPase domain immediately downstream (

). Proteins containing this domain are signal-transduction-response receivers. They are localised to the cytoplasmic side of the inner bacterial cell-membrane, contacting also with both TadA and RcpC .
Mannosyl phosphorylinositol ceramide synthase regulatory protein Csg2 (Csg2)
Type: Family

Csg2 is an integral membrane protein with up to 10 transmembrane segments that, when over-expressed, localises to the endoplasmic reticulum . It regulates mannosyl phosphorylinositol ceramide synthase and is thereby implicated in calcium homoeostasis in the cell .
Putative tight adherence pilin protein F (TadF)
Type: Family

TadF is a family of proteins from the tad locus that is part of the type IV bacterial secretory system .
PelD, GGDEF domain (PelD_GGDEF)
Type: Domain

This degenerate GGDEF domain is found at the C-terminal of PelD, a membrane-bound c-di-GMP-specific receptor. It contains an RXXD motif similar to the allosteric inhibition site found in diguanylate cyclases. In PelD this RXXD motif binds to dimeric c-di-GMP .
Putative ABC exporter (Put_ABC_export)
Type: Family

This is a family of putative ABC exporters mostly from Firmicutes.
Putative OmpA-OmpF-like porin family (OmpA_OmpF-like)
Type: Family

This is a family of putative OmpA-OmpF-like porins from Bacteroidetes.
Haemoglobin-haptoglobin utilisation, porphyrin transporter (HpuA)
Type: Family

HpuA is a family of Neisseria spp proteins from the hpuAB operon, which are putative porphyrin transporters .
Lung adenoma susceptibility protein 2 (LAS2)
Type: Family

LAS2 is a family of eukaryotic proteins. Deletion of LAS2 is observed in approx. 40% of human lung adenocarcinomas, suggesting that loss of function of LAS2 may be a key step for promoting lung tumourigenesis .
Collectrin domain (Collectrin_dom)
Type: Domain

This domain is found in collectrin, a single-pass transmembrane protein that regulates SNARE complex function . This domain can be also found in the C-terminal region of human angiotensin-converting enzyme 2, ACE2 .

The transmembrane protease angiotensin converting enzyme 2 (ACE2) is a protective regulator within the renin angiotensin system and additionally represents the cellular receptor for SARS-CoVs. It functions as carboxypeptidase and cleaves the C-terminal amino acid of angiotensin I to
angiotensin 1-9 or directly converts angiotensin II to angiotensin 1-7. ACE2 consists of an N-terminal catalytically active metalloprotease domain and a C-terminal collectrin-like domain .

Collectrin is a type I membrane protein and shares significant homology with the C-terminal domain of ACE2. However, collectrin lacks catalytic domain and it suggests the presence of uncharacterised physiological functions of collectrin. Collectrin binds to SNARE complex protein such as snapin and the collectrin-mediated processes of vesicle transport and fusion to the plasma membrane in a polarized manner is crucial for delivering insulin and amino acid transporters .

The collectrin-like domain mediates homodimerization. It consists of a small extracellular neck subdomain, which adopts a ferredoxin-like fold, a long
linker, and a single transmembrane (TM) helix

.
Shieldin complex subunit 2, C-terminal domain (SHLD2_C)
Type: Domain

This entry represents the C-terminal OB fold domain found in Shieldin complex subunit 2 (SHLD2, formerly known as FAM35A). SHLD2 is a component of the shieldin complex, which plays an important role in repair of DNA double-stranded breaks (DSBs) .
Pre-mRNA-splicing factor Prp9, N-terminal (PRP9_N)
Type: Domain

This is the N-terminal domain of pre-mRNA-splicing factor Prp9 . mRNA splicing factors, PRP9, PRP11, and PRP21, are necessary for binding of the U2 snRNP to the pre-mRNA in an early step of spliceosome assembly .
Coiled-coil domain-containing protein 106 (CCDC106)
Type: Family

CCDC106, coiled-coil domain-containing protein 106, is a family of eukaryote proteins. Yeast two-hybrid screening has identified CCDC106 as a p53-interacting partner . CCDC106 is a negative regulator of p53 and may be involved in tumourigenesis in some cancers by promoting the degradation of p53 protein and inhibiting its transactivity .
Putative general bacterial porin (Porin_7)
Type: Family

This entry represent a group of putative general bacterial porins.
Putative iron/lead transporter (OFeT_1)
Type: Family

This is a family of conserved archaeal and bacterial membrane proteins that are putative oxidase-dependent Fe2+/Pb2+ transporters.
Protein-only RNase P, C-terminal (PRORP_C)
Type: Domain

This entry represents a domain found in protein-only RNase P (PRORP), an enzyme that processes precursor tRNAs in human mitochondria and in all tRNA-using compartments of Arabidopsis thaliana. PRORP catalyses the maturation of the 5' ends of tRNA precursors .
Putative methionine and alanine importer, small subunit (MaAIMP_sms)
Type: Family

This is a family of hypothetical proteins from eubacteria purported to be small subunits of a methionine and alanine importer.
KELK-motif containing domain (KELK)
Type: Domain

KELK is a domain of eukaryotic proteins found in serine/threonine-protein kinase MRCK-type proteins . The region is low-complexity, but it is not a predicted disordered-binding domain. The name comes from a highly conserved sequence motif within the domain. The function is not known.
Putative ATP-binding cassette (ABC_tran_2)
Type: Family

This is the permease protein of a putative two component ABC exporter. It is a membrane protein of approximately 573 residues and twelve transmembrane domains. It is encoded adjacent to an ATPase.
Domain of unknown function DUF4706 (DUF4706)
Type: Domain

This domain is found in eukaryotes, and is approximately 110 amino acids in length.
Coiled-coil domain-containing protein 48 (CCD48)
Type: Family

The function of coiled-coil domain-containing protein 48 (CCDC48), also known as EF-hand and coiled-coil domain-containing protein 1 (EFCC1), is not known. Proteins in this family are typically between 161 and 575 amino acids in length.
Clock-interacting pacemaker (CIPC)
Type: Family

Clock-interacting pacemaker or clock-interacting circadian protein (CIPC) is an additional negative-feedback regulator of the circadian clock, through inhibition of CLOCK-BMAL1 activity . Studies in knockout mice suggest that it may not be critically required for basic clock function .
4Fe-4S ferredoxin iron-sulfur binding domain-containing protein, N-terminal (Ferredoxin_N)
Type: Domain

This is a short domain that is often found in the N-terminal of 4Fe-4S ferredoxin iron-sulfur binding domain proteins from Archaea and a few bacteria.
Putative OMPG-porin 1 family (Porin_OmpG_1_2)
Type: Family

This is a family of putative porins of the OmpG-type. These are channels without solute specificity.
Potassium transporter Kch (Kch1/2)
Type: Family

Kch family members are potassium transporters that mediate K+ influx. Budding yeast Kch1 and its paralogue, Kch2, promote low-affinity K+ uptake and are essential for K+-dependent activation of HACS during mating pheromone response .
Cag pathogenicity island, type IV secretory system (T4SS_CagC)
Type: Family

This is a family of putative pathogenicity island, type IV, conjugal DNA-protein transfer, secretory system proteins from bacteria .
Putative cyclic bacteriocin (CclA_1)
Type: Family

This is a family of short proteins from Gram-positive bacteria, putatively from the carnocylcin A family of bacteriocins.
Cyclodextrin porin CymA (CymA)
Type: Family

CymA has been identified in Klebsiella oxytoca as the outer membrane component of the cyclodextrin (CD) uptake and metabolism system .