SII-SWORD/CoKE huggingface dataset:
Pfam PF06636: Protein of unknown function (DUF1157) (family)
This family consists of several uncharacterised proteins from Melanoplus sanguinipes entomopoxvirus (MsEPV). The function of this family is unknown.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF00041: Fibronectin type III domain (domain)
Fibronectin is a dimeric glycoprotein composed of disulfide-linked subunits with a molecular weight of 220-250kDa each. It is involved in cell adhesion, cell morphology, thrombosis, cell migration, and embryonic differentiation. Fibronectin is a modular protein composed of homologous repeats of three prototypical types of domains known as types I, II, and III .

Fibronectin type-III (FN3) repeats are both the largest and the most common of the fibronectin subdomains. Domains homologous to FN3 repeats have been found in various animal protein families including other extracellular-matrix molecules, cell-surface receptors, enzymes, and muscle proteins . Structures of individual FN3 domains have revealed a conserved Î²-sandwich fold with one Î²-sheet containing four strands and the other sheet containing three strands (see for example 1TEN) . This fold is topologically very similar to that of Ig-like domains, with a notable difference being the lack of a conserved disulfide bond in FN3 domains. Distinctive hydrophobic core packing and the lack of detectable sequence homology between immunoglobulin and FN3 domains suggest, however, that these domains are not evolutionarily related .

FN3 exhibits functional as well as structural modularity. Sites of interaction with other molecules have been mapped to short stretch of amino acids such as the Arg-Gly-Asp (RGD) sequence found in various FN3 domains. The RGD sequences is involved in interactions with integrin. Small peptides containing the RGD sequence can modulate a variety of cell adhesion invents associated with thrombosis, inflammation, and tumour metastasis. These properties have led to the investigation of RGD peptides and RGD peptide analogues as potential therapeutic agents .
Wikipedia: The Fibronectin type III domain  is an evolutionarily conserved protein domain that is widely found in animal proteins. The fibronectin protein in which this domain was first identified contains 16 copies of this domain. The domain is about 100 amino acids long and possesses a beta sandwich structure. Of the three fibronectin-type domains, type III is the only one without disulfide bonding present. Fibronectin domains are found in a wide variety of extracellular proteins. They are widely distributed in animal species, but also found sporadically in yeast, plant and bacterial proteins.
Pfam PF05400: Flagellar protein FliT (family)
This family contains several bacterial flagellar FliT proteins. The  flagellar proteins FlgN and FliT have been proposed to act as substrate specific export chaperones, facilitating incorporation of the enterobacterial hook-associated axial proteins (HAPs) FlgK/FlgL and FliD into the growing flagellum. In Salmonella typhimurium flgN and fliT mutants, the export of target HAPs is reduced, concomitant with loss of unincorporated flagellin into the surrounding medium.
Pfam PF24584: CYK3 C-terminal Ig-like domain (domain)
This domain is found C-terminal in the yeast Cytokinesis protein 3 (CYK3) and related proteins. CYK3 is involved in cytokinesis by recruiting INN1 to the bud neck. It is found in association with the actin ring and the mother-bud neck. The domain represented by this entry is predicted to fold into a beta-sandwich with an Ig-like topology. This domain has a detectable sequence similarity to Ig-like domains e.g. to filamin.
Pfam PF18999: Family of unknown function (DUF5728) (family)
This is a highly conserved domain of unknown function found in Platyhelminthes, with many of the sequences annotated as being the small conductance calcium-activated potassium channel protein. However, the location suggests that this domain belongs to the intracellular amino terminus of these transmembrane proteins, immediately next to the calcium-activated SK potassium channel.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF07575: Nup85 Nucleoporin (repeat)
A family of nucleoporins conserved from yeast to human. THe nuclear pore complex is a large assembly composed of two essential complexes: the heptameric Nup84 complex and the heteromeric Nic96-containing complex.  The Nup84 complex is composed of one copy each of Nup84, Nup85, Nup120, Nup133, Nup145C, Sec13, and Seh1. The structure of a complex of Nup85 and Seh1 was solved. The N-terminus of Nup85 is inserted and forms a three-stranded blade that completes the Seh1 6-bladed beta-propeller in trans. Following its N-terminal insertion blade, Nup85 forms a compact cuboid structure composed of 20 helices, with two distinct modules, referred to as crown and trunk.
Pfam PF13702: Lysozyme-like (domain)
This domain is also present in poorly characterised proteins, namely the pneumococcal vaccine antigen A and YocA from B. subtilis .
CwlT is a bifunctional cell wall hydrolase containing an N-terminal lysozyme domain and a C-terminal NlpC/P60 endopeptidase domain, and has been implicated in the spread of transposons . This entry represents the N-terminal domain which acts as a N-acetylmuramidase that cleaves the bond between N-acetylmuramic acid and N-acetyl-D-glucosamine (MurNAc-GlcNAc) in peptidoglycan . It has structural similarities with lytic transglycosylases and lysozyme G. CwlT is required for ICEBs1 conjugation for which the muramidase activity is essential .
Pfam PF01404: Ephrin receptor ligand binding domain (domain)
The Eph receptors, which bind to ephrins [pfam:PF00812] are a large family of receptor tyrosine kinases.  This family represents the amino terminal domain which binds the ephrin ligand.
Wikipedia: Eph receptors are a group of receptors that are activated in response to binding with Eph receptor-interacting proteins (Ephrins). Ephs form the largest known subfamily of receptor tyrosine kinases (RTKs). Both Eph receptors and their corresponding ephrin ligands are membrane-bound proteins that require direct cell-cell interactions for Eph receptor activation. Eph/ephrin signaling has been implicated in the regulation of a host of processes critical to embryonic development including axon guidance, formation of tissue boundaries, cell migration, and segmentation. Additionally, Eph/ephrin signaling has been identified to play a critical role in the maintenance of several processes during adulthood including long-term potentiation, angiogenesis, and stem cell differentiation and cancer.
Pfam PF16777: Transcriptional regulator, RHH-like, CopG (domain)
RHH_7 is a ribbon-helix-helix protein family expressed by Helicobacter species. These proteins bind to specific DNA sequences with high affinity and usually act as repressors. Many are putatively named CopG.
Pfam PF11872: Protein of unknown function (DUF3392) (family)
This family of proteins are functionally uncharacterised. This protein is found in bacteria. Proteins in this family are about 110 amino acids in length.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF16344: FecR, C-terminal (domain)
This domain is found at the C-terminal of FecR, which adopts a secretin N0-like fold. FecARI are responsible for induction of the ferric citrate uptake system. When ferric citrate binds FecA, a signal is transmitted across the outer membrane to FecR, a cytoplasmic membrane protein that transmits signal across the membrane and activates the sigma-70 family protein FecI.
Pfam PF23597: Dyslexia-associated protein KIAA0319 N-terminal domain (domain)
This domain is found N-terminal in the human Dyslexia -associated protein KIAA0319 and related proteins. KIAA0319 is involved in neuronal migration during development of the cerebral neocortex. This protein is linked to migrational disturbances during brain development, and growth and differentiation of dendrites. Another protein containing this domain, KIAA0319L, is capable of rapid endocytosis from the plasma membrane and trafficking to the trans-Golgi network. This protein directly binds to Adeno-associated virus 2 particles and it is involved in the virus infection. The domain represented in this entry shares significant sequence similarity to MANEC domain and adopts the same structure.
Pfam PF03234: Cdc37 N terminal kinase binding (domain)
Cdc37 is a molecular chaperone required for the activity of numerous eukaryotic protein kinases.  This domain corresponds to the N terminal domain which binds predominantly to protein kinases and is found N terminal to the Hsp (Heat shocked protein) 90-binding domain [pfam:PF08565].  Expression of a construct consisting of only the N-terminal domain of Saccharomyces pombe Cdc37 results in cellular viability.  This indicates that interactions with the cochaperone Hsp90 may not be essential for Cdc37 function.
Wikipedia: Hsp90 co-chaperone Cdc37 is a protein that in humans is encoded by the CDC37 gene. This protein is highly similar to Cdc 37, a cell division cycle control protein of Saccharomyces cerevisiae. This protein is a HSP90 Co-chaperone with specific function in cell signal transduction. It has been shown to form complex with Hsp90 and a variety of protein kinases including CDK4, CDK6, SRC, RAF1, MOK, as well as eIF-2 alpha kinases. It is thought to play a critical role in directing Hsp90 to its target kinases.
Pfam PF21183: Histone acetyltransferase type B catalytic subunit, C-terminal (domain)
Histone acetyltransferase type B catalytic subunit (HAT1) is the catalytic subunit of the histone acetylase B (HAT-B) complex (composed on HAT1 and HAT2 at least). It is involved in different biological processes including cell progression, glucose metabolism, histone production or DNA damage repair. HAT1 acetylates histone H4 at Lys-5 and Lys-12, and to a lesser extend, Lys-5 in histone H2A. The C-terminal domain of HAT1 is highly variable and not required for HAT activity. It consists of a bundle of helices and a short beta-strand. This entry includes HAT1 from animals.
Pfam PF24468: LRP2-like, EGF-like domain (domain)
This EGF-like domain is found in human Low-density lipoprotein receptor-related protein 2 (LRP2) and similar animal proteins. LRP2 is a multiligand endocytic receptor.
Pfam PF08216: Catenin-beta-like, Arm-motif containing nuclear (repeat)
CTNNBL is a family of eukaryotic nuclear proteins of the catenin-beta-like 1 type that contain an armadillo motif. A human nuclear protein with this domain ([swissprot:Q8WYA6]) is thought to have a role in apoptosis. The interaction of CTNNBL1 with its known partners (the Prp19-CDC5L complex and AID) is mediated by recognition of NLS (nuclear localisation signal) motifs. The RNA-splicing factor Prp31 is also an interactor, with recognition also occurring through the NLS. CTNNBL1 uses its central armadillo (ARM) domain to bind NLS-containing partners.
Pfam PF17438: Family of unknown function (DUF5417) (family)
This is a family of unknown function found in Proteobacteria.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF06746: Protein of unknown function (DUF1216) (family)
This family represents a conserved region, within Arabidopsis thaliana proteins, of unknown function. Family members sometimes contain more than one copy.It has been reported that this domain will be found in other Brassicaceae.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF18795: DNA mismatch repair protein HSM3, N terminal domain (repeat)
Hsm3 is a proteasome-dedicated chaperone that forms a base precursor, Hsm3-Rpt1-Rpt2-Rpn1. Hsm3 consists of 23 alpha-helices forming 11 repeats similar to the HEAT repeats. This entry includes the first 5  repeats at the N-terminal.
Pfam PF13208: TerB N-terminal domain (family)
The TerB_N domain is found N-terminal to TerB, and TerB_C containing proteins. It has a predominantly alpha-helical structure and contains an absolutely conserved glutamate. The presence of a conserved acidic residue suggests that it might chelate metal like TerB. These proteins occur in a two-gene operon containing an AAA+ ATPase and SF-II DNA helicase suggesting a role in stress-response or phage defence.
Pfam PF22795: DUF4796 N-terminal (domain)
This cysteine-rich domain is functionally uncharacterised and is found in eukaryotes. Proteins with this domain are typically between 194 and 289 amino acids in length. AlphaFold structural models reveal a C-terminal beta-strand, usually located after the DUF4796_C domain ([pfam:PF16044]). This beta-strand (not included in this entry's seed alignment) contributes to the beta-sheet structure within this domain.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF19513: Family of unknown function (DUF6047) (family)
This family of proteins is functionally uncharacterised. This family of proteins is found in Bacteroidetes bacteria. Proteins in this family are typically between 238 and 400 amino acids in length.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF05953: Allatostatin (family)
This family consists of allatostatins, bombystatins, helicostatins, cydiastatins and schistostatin from several insect species. Allatostatins (ASTs) of the Tyr/Phe-Xaa-Phe-Gly Leu/Ile-NH2 family are a group of insect neuropeptides that inhibit juvenile hormone biosynthesis by the corpora allata.
Pfam PF22362: Argonaute, middle domain, bacteria (domain)
This entry represents the middle domain of bacterial argonaute (Ago). Ago bind small RNA or DNA guides which provide base-pairing specificity for recognition and cleavage of complementary nucleic acid targets. Bacterial Ago adopt a bilobed structure; an N-terminal and a PAZ domain constitute one lobe, the second one consists of a middle (MID) domain and the catalytic PIWI domain. This domain mediates the recognition of the 5' end of the guide.
Pfam PF12200: Domain of unknown function (DUF3597) (domain)
This family of proteins is found in bacteria, eukaryotes and viruses.  Proteins in this family are typically between 126 and 281 amino acids in length. The function of this domain is unknown. The structure of this domain has been found to contain five helices with a long flexible loop between helices one and two.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF03067: Lytic polysaccharide mono-oxygenase, cellulose-degrading (domain)
This domain is found associated with a wide variety of cellulose binding domains. This is a family of two very closely related proteins that together act as both a C1- and a C4-oxidising lytic polysaccharide mono-oxygenase, degrading cellulose. This domain is also found in baculoviral spheroidins and spindolins, protein of unknown function.
Wikipedia: In molecular biology, a carbohydrate-binding module (CBM) is a protein domain found in carbohydrate-active enzymes. The majority of these domains have carbohydrate-binding activity. Some of these domains are found on cellulosomal scaffoldin proteins. CBMs were previously known as cellulose-binding domains. CBMs are classified into numerous families, based on amino acid sequence similarity. There are currently 64 families of CBM in the CAZy database.
Pfam PF24034: Domain of unknown function (DUF7343) (domain)
This entry represents the HTH domain found in group of uncharacterised archaeal proteins.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF02424: ApbE family (family)
This prokaryotic family of lipoproteins are related to ApbE from Salmonella typhimurium. ApbE is involved in thiamine synthesis.  It acts as an FAD:protein FMN-transferase, catalysing the attachment of an FMN residue to a threonine residue of a protein via a phosphoester bond in such bacterial flavoproteins.
Pfam PF11810: Domain of unknown function (DUF3332) (family)
This family of proteins are functionally uncharacterised. This family is only found in bacteria.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF20130: Family of unknown function (DUF6520) (family)
This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 89 and 103 amino acids in length.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF24754: Macrodomain effector MavL (family)
This entry represents the Legionella macrodomain effector MavL, an ADP-ribosyl hydrolase that reverses the arginine ADP-ribosylation, to minimize potential detrimental effects caused by the modified ubiquitin. Legionella pneumophila mediates atypical ubiquitination of host targets using the SidE effector family.
Pfam PF03118: Bacterial RNA polymerase, alpha chain C terminal domain (domain)
The alpha subunit of RNA polymerase consists of two independently folded domains, referred to as amino-terminal and carboxyl terminal domains.  The amino terminal domain is involved in the interaction with the other subunits of the RNA polymerase.  The carboxyl-terminal domain interacts with the DNA and activators.  The amino acid sequence of the alpha subunit is conserved in prokaryotic and chloroplast RNA  polymerases. There are three regions of particularly strong  conservation, two in the amino-terminal and one in the carboxyl- terminal.
Pfam PF19796: Family of unknown function (DUF6280) (family)
This family of proteins is functionally uncharacterised. This family of proteins is found in Alphaproteobacteria. Proteins in this family are approximately 110 amino acids in length.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF11259: Protein of unknown function (DUF3060) (family)
Some members in this family of proteins are annotated as membrane proteins however this cannot be confirmed.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF10337: Putative ER transporter, 6TM, N-terminal (family)
This is a family of proteins conserved in fungi. The function is not known. This family is the C-terminal half of some member proteins which contain the DUF2421 [pfam:PF10334] domain at their N-terminus. These proteins are putative endoplasmic reticulum tranpsorters, with a total of 12 TMs.
Pfam PF10977: Protein of unknown function (DUF2797) (family)
This family of proteins has no known function.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF17126: RsmF rRNA methyltransferase first C-terminal domain (domain)
This is the first of two distinct C-terminal domains of the 16S rRNA methyltransferase RsmF. It is necessary for stabilising the catalytic core, [pfam:PF01189].