SII-SWORD/CoKE huggingface dataset:
Pfam PF03596: Cadmium resistance transporter (family)
These proteins are members of the Cadmium Resistance (CadD) family. The CadD family includes two close orthologues in two Staphylococcus species that have been reported to function in cadmium resistance .
Wikipedia: The cadmium resistance (CadD) protein family belongs to the Lysine exporter (LysE) superfamily. CadD members facilitate the export of cationic compounds such as cadmium ions.
Pfam PF04675: DNA ligase N terminus (family)
This region is found in many but not all ATP-dependent DNA ligase enzymes ([ec:6.5.1.1]).  It is thought to be involved in DNA binding and in catalysis. In human DNA ligase I ([swissprot:P18858]), and in Saccharomyces cerevisiae ([swissprot:P04819]), this region was necessary for catalysis, and separated from the amino terminus by targeting elements. In vaccinia virus ([swissprot:P16272]) this region was not essential for catalysis, but deletion decreases the affinity for nicked DNA and decreased the rate of strand joining at a step subsequent to enzyme-adenylate formation.
Pfam PF19282: Exportin-T (repeat)
Exportin-T mediates the nuclear export of aminoacylated tRNAs. Its budding yeast homologue, known as Los1, is involved in nuclear export of pre-tRNA and in re-export of mature tRNAs. It binds to RanGTP and mature tRNAs cooperatively to form a nuclear export complex.
Pfam PF19556: PRTRC system protein E (family)
A novel genetic system characterized by six or seven major proteins, included a ParB homolog and a ThiF homolog, is designated PRTRC, or ParB-Related,ThiF-Related Cassette. It is often found on plasmids. This protein family averages about 150 amino acids in length, but the last third contains low-complexity sequence that complicates sequence comparisons.
Pfam PF01101: HMG14 and HMG17 (family)
This entry represents the HMGN family, whose members promote chromatin unfolding, enhance access to nucleosomes, and modulate transcription from chromatin templates. HMGNs are expressed only in vertebrates .
The high mobility group (HMG) proteins are the most abundant and ubiquitous nonhistone chromosomal proteins. They bind to DNA and to nucleosomes and are involved in the regulation of DNA-dependent processes such as transcription, replication, recombination, and DNA repair. They can be grouped into three families: HMGB (HMG 1/2), HMGN (HMG 14/17) and HMGA (HMG I/Y). The characteristic domains are: AT-hook for the HMGA family, the HMG Box for the HMGB family, and the nucleosome-binding domain (NBD) for the members of the HMGN family .
Wikipedia: High mobility group protein HMG14 and HMG17 also known as nucleosomal binding domain is a family of evolutionarily related proteins.
Pfam PF06980: Protein of unknown function (DUF1302) (domain)
This entry represents a family of predicted outer membrane beta barrel proteins.  These proteins remain uncharacterised. They are approximately 600 residues long. These proteins are likely part of an exporter system that includes an MMPL exporter, a DUF1329 protein [pfam:PF07044] family protein that likely acts as a LolA-like chaperone.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF24579: Phage putative PDDEXK endonuclease (domain)
This entry represents a small family of phage proteins that are structurally related to the PD-(D/E)XK nuclease superfamily. The highest structural similarity is to Holliday junction resolvase Hjc proteins and tRNA-splicing endonucleases from archaebacteria. The exact function of this protein family is unknown.
Pfam PF13856: ATP-binding sugar transporter from pro-phage (domain)
Members of this short family are putative ATP-binding sugar transporter-like protein.
Pfam PF04850: Baculovirus E66 occlusion-derived virus envelope protein (repeat)
This entry represents the C-terminal domain of Non-sulfated chondroitin lyase E66 from Autographa californica nuclear polyhedrosis virus (ODV-E66) and similar sequences from baculovirus. This domain, predominantly formed by Î²-strands, is often found associated with IPR012970.
ODV-E66 is a component of the polyhedra envelope that plays an essential role in oral infectivity. It may digest, with its chondroitin lyase activity, the chondroitin sulfate barrier of the peritrophic matrix of the host midgut to facilitate viral infection in the epithelial cells .
Baculovirus occlusion-derived virus (ODV) derives its envelope from an intranuclear membrane source. N-terminal amino acid sequences of the Autographa californica MNPV nuclear polyhedrosis virus (AcMNPV) envelope protein ODV-E66 is highly hydrophobic. This defined hydrophobic domain was shown to direct the protein, E66, to induce membrane microvesicles within a baculovirus-infected cell nucleus and the viral envelope. In addition, it was suggested that movement of this protein into the nuclear envelope may initiate through cytoplasmic membranes, such as endoplasmic reticulum, and that transport into the nucleus may be mediated through the outer and inner nuclear membrane .
Pfam PF21639: ORC5, lid domain (domain)
ORC5 is a component of the origin recognition complex (ORC) that binds origins of replication. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. This is the lid domain, which with the N-terminal RecA-fold domain, constitutes the well-known AAA+ domain.
Pfam PF19372: Family of unknown function (DUF5947) (family)
This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0001065) is described by MIBiG as an example of the following biosynthetic class, polyketide.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF12383: Severe acute respiratory syndrome coronavirus 3b protein (family)
This family of proteins is found in viruses. Proteins in this family are typically between 32 and 154 amino acids in length. This family contains the SARS coronavirus 3b protein which is predominantly localized in the nucleolus, and induces G0/G1 arrest and apoptosis in transfected cells.
Pfam PF21282: APC1 beta sandwich domain (domain)
This domain is found close to the C-terminus of the APC1 protein which is a component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle.
Pfam PF04210: Tetrahydromethanopterin S-methyltransferase, subunit G (family)
The N5-methyltetrahydromethanopterin: coenzyme M ([ec:2.1.1.86]) of Methanosarcina mazei Go1 is a membrane-associated, corrinoid-containing protein that uses a transmethylation reaction to drive an energy-conserving sodium ion pump.
Pfam PF08125: Mannitol dehydrogenase C-terminal domain (domain)
Long-chain mannitol dehydrogenases are a group of secondary alcohol dehydrogenases that differ from other alcohol or polyol dehydrogenases in that they do not utilise Zn(2+) or other metal cofactors and do not contain a conserved catalytic tyrosine residue. The proteins in this family that have been studied are monomeric enzymes of ~54kDa and include:
 * Mannitol-1-phosphate 5-dehydrogenase (1.1.1.17) 
 * Mannitol 2-dehydrogenase (1.1.1.67) 
 * D-arabinitol 4-dehydrogenase (1.1.1.11) 
 * Altronate oxidoreductase (1.1.1.58)
 * D-mannonate oxidoreductase (1.1.1.57)

These enzymes are mostly found in bacteria, though they are also present in some fungal species.
Pfam PF14860: DrrA phosphatidylinositol 4-phosphate binding domain (domain)
This domain binds to phosphatidylinositol 4-phosphate. It is found in Legionella pneumophila DrrA, a protein involved in the redirection of endoplasmic reticulum-derived vesicles to the Legionella-containing vacuoles.
Pfam PF10853: Protein of unknown function (DUF2650) (family)
This family of proteins with unknown function appear to be restricted to Caenorhabditis elegans.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF25086: Domain of unknown function (DUF7803) (domain)
This domain is found in uncharacterised proteins mainly from plants. It is predicted to fold into four helices that form two helical hairpins arranged in V-shape.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF03384: Drosophila protein of unknown function, DUF287 (family)
This is a domain is found predominantly in Arabidopsis proteins. Its function is unknown.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF01115: F-actin capping protein, beta subunit (family)
The F-actin capping protein binds in a calcium-independent manner to the fast growing ends of actin filaments (barbed end) and thereby restricts its growth. The F-actin capping protein is a heterodimer composed of two unrelated subunits: alpha and beta. Neither of the subunits shows sequence similarity to other filament-capping proteins .

This entry represents the beta subunit (CAPZB), which is a protein of about 280 amino acid residues whose sequence is well conserved in eukaryotic species . In Drosophila mutations in the alpha and beta subunits cause actin accumulation and subsequent retinal degeneration . In humans CAPZB is part of the WASH complex that controls the fission of endosomes .
Wikipedia: In molecular biology, the F-actin capping protein is a protein complex which binds in a calcium-independent manner to the fast-growing ends of actin filaments, thereby blocking the exchange of subunits at these ends. Unlike gelsolin and severin this protein does not sever actin filaments. The F-actin capping protein is a heterodimer composed of two unrelated subunits: alpha and beta. Neither of the subunits shows sequence similarity to other filament-capping proteins. The alpha subunit is a protein of about 268 to 286 amino acid residues and the beta subunit is approximately 280 amino acids, their sequences are well conserved in eukaryotic species.
Pfam PF22802: RsiG-like (domain)
This entry represents a domain found in homologues of RsiG protein from Streptomyces. This domain adopts an alpha-helix and in Streptomyces self associates to form a dimer. This dimer binds c-di-GMP via two E(X)3-S(X)2-R(X)3-Q(X)-D repeat motifs, one on each helix. The complex RsiG-(c-di-GMP) binds to the sporulation-specific sigma factor, WhiG. Some homologues of RsiG contain a second helix and hence two c-di-GMP binding motifs.
Pfam PF09256: BAFF-R, TALL-1 binding (domain)
Members of this family, which are predominantly found in the tumour necrosis factor receptor superfamily member 13c, BAFF-R, are required for binding to tumour necrosis factor ligand TALL-1.
Pfam PF02998: Lentiviral Tat protein (family)
This family contains retroviral transactivating (Tat) proteins, from a variety of Lentiviruses.
Pfam PF08635: Putative oxidoreductase C terminal domain (domain)
This is the C-terminal domain of a family of putative oxidoreductases.
Pfam PF15189: Meiosis-specific coiled-coil domain-containing protein MEIOC (family)
This family of proteins is found in eukaryotes. In humans,  it is encoded for on the chromosomal position C17orf104.
Pfam PF20919: DWD hypersensitive to UV-B 1, N-terminal (repeat)
This entry represents the N-terminal domain of DWD hypersensitive to UV-B 1 from Arabidopsis thaliana, which may act as a substrate receptor of a CUL4-RING E3 ubiquitin-protein ligase (CRL4) complex involved in the negative regulation of cellular responses to ultraviolet-B (UV-B) illumination, likely in coordination with RUP1. It interacts with COP1 and probably prevents the formation of active UVR8-COP1 complex thus avoiding UVR8-COP1-mediated positive regulation of UV-B responses. DHU1 consists of two distant domains, LRR included in this entry and WD40 ([pfam:PF00400]), which mediate protein-protein interactions.
Pfam PF13302: Acetyltransferase (GNAT) domain (domain)
This domain catalyses N-acetyltransferase reactions.
Wikipedia: An acetyltransferase is any of a class of transferase enzymes that transfers an acetyl group in a reaction called acetylation. In biological organisms, post-translational modification of a protein via acetylation can profoundly transform its functionality by altering various properties like hydrophobicity, solubility, and surface attributes. These alterations have the potential to influence the protein's conformation and its interactions with substrates, cofactors, and other macromolecules.
Pfam PF00164: Ribosomal protein S12/S23 (domain)
This protein is known as S12 in bacteria and archaea and S23 in eukaryotes.
Pfam PF01422: NF-X1 type zinc finger (family)
This domain is presumed to be a zinc binding domain. The following pattern describes the zinc finger. C-X(1-6)-H-X-C-X3-C(H/C)-X(3-4)-(H/C)-X(1-10)-C Where X can be any amino acid, and numbers in brackets indicate the number of residues. Two position can be either his or cys. This family includes [swissprot:P40798], [swissprot:Q12986] and [swissprot:P53971]. The zinc fingers in [swissprot:Q12986] bind to DNA.
Pfam PF19277: Glycerol-3-phosphate acyltransferase C-terminal region (family)
This entry represents the C-terminal region of Glycerol-3-phosphate acyltransferase and Dihydroxyacetonephosphate acyltransferase (DHAPAT).
Pfam PF12735: TRAPP trafficking subunit Trs65 IgD3 (domain)
This entry includes Trp65, an essential subunit of the TRAPP Golgi trafficking complex. TRAPP subunits are found in three forms-core TRAPP/TRAPPI, TRAPPII, and TRAPPIII and they function in various vesicle trafficking pathways. TRAPPI mediates transport from endoplasmic reticulum to cis-Golgi by tethering COPII-coated vesicles; TRAPPII interacts with COPI-coated vesicles in mammalian cells and aids in endosome-to-Golgi transport, and TRAPPIII plays a unique role in autophagy. TRAPP complexes act as GEFs and play an essential role in catalysing nucleotide exchange for Ypt/Rab GTPase. The three complexes share a core of six different proteins (Bet3, Bet5, Trs20, Trs23, Trs31, and Trs33) that make up core TRAPPI. TRAPPII contains four additional proteins (Trs120, Trs130, Trs65, and Tca17), and TRAPPIII has one additional Trs85 in yeast. while Trp65 has been implicated in cell wall biogenesis and stress response, the role of Trs65 in TRAPPII is supported by the findings that the protein co-localises with Trs130p, and deletion of Trs65 in yeast leads to a conditional lethal phenotype if either one of the other TRAPPII-specific subunits is modified. Trs65 is essential to the formation of TRAPPII dimer and consists of three Ig-like domains (IgD1, IgD2 and IgD3). This entry represents IgD3 domain of Trs65.
Pfam PF23539: Domain of unknown function (DUF7134) (domain)
This domain is composed of 6 transmembrane alpha helices and is found at the N-terminus of a large family of bacterial signalling proteins. It is structurally related to the N-terminus of the DesK protein. That region is believed to be involved in sensing membrane fluidity.ED   A0A1A9IX15.1/7-166; A0A1A9IX15.1/7-50;
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF15479: Domain of unknown function (DUF4639) (family)
This family of proteins is found in eukaryotes. Proteins in this family are typically between 161 and 601 amino acids in length.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF09470: Telethonin protein (domain)
Telethonin is a 167-residue protein which complexes with the large muscle protein, titin. The very N-terminus of titin, composed of two immunoglobulin-like (Ig) domains, referred to as Z1 and Z2, interacts with the N-terminal region (residues 1-53) of telethonin, mediating the antiparallel assembly of two Z1Z2 domains. The C-terminus of the telethonin appears to induce dimerisation of this 2:1 titin/telethonin structure which thus forms a complex necessary for myofibril assembly and maintenance of the intact Z-disk of skeletal and cardiac muscles.
Pfam PF03707: Bacterial signalling protein N terminal repeat (repeat)
Found as an N terminal triplet tandem repeat in bacterial signalling proteins. Family includes CoxC ([swissprot:Q9KX27]) and CoxH ([swissprot:Q9KX23]) from P.carboxydovorans. Each repeat contains two transmembrane helices. Domain is also described as the MHYT domain.
Pfam PF00523: Fusion glycoprotein F0 (family)
The fusion glycoproteins from this family are found in ssRNA negative-strand viruses. This protein directs fusion of viral and cellular membranes, resulting in viral penetration, and can direct fusion of infected cells with adjoining cells, resulting in the formation of syncytia. The mature form is a dimer of polypeptides F1 and F2 linked by a disulphide bond .
Pfam PF17482: Phage tail sheath C-terminal domain (domain)
This entry represents the C-terminal domain in a variety of phage tail sheath proteins.
Pfam PF07732: Multicopper oxidase (domain)
This entry contains many divergent copper oxidase-like domains that are not recognised by the [pfam:PF00394] model.
Wikipedia: In molecular biology, multicopper oxidases are enzymes which oxidise their substrate by accepting electrons at a mononuclear copper centre and transferring them to a trinuclear copper centre; dioxygen binds to the trinuclear centre and, following the transfer of four electrons, is reduced to two molecules of water. There are three spectroscopically different copper centres found in multicopper oxidases: type 1, type 2 and type 3. Multicopper oxidases consist of 2, 3 or 6 of these homologous domains, which also share homology with the cupredoxins azurin and plastocyanin. Structurally, these domains consist of a cupredoxin-like fold, a beta-sandwich consisting of 7 strands in 2 beta-sheets, arranged in a Greek-key beta-barrel.
Pfam PF04847: Calcipressin (family)
Calcipressin is also known as calcineurin-binding protein, since it inhibits calcineurin-mediated transcriptional modulation by binding to calcineurin's catalytic domain.
Wikipedia: In molecular biology, the calcipressin family of proteins negatively regulate calcineurin by direct binding. They are essential for the survival of T helper type 1 cells. Calcipressin 1 is a phosphoprotein that increases its capacity to inhibit calcineurin when phosphorylated at the conserved FLISPP motif; this phosphorylation also controls the half-life of calcipressin 1 by accelerating its degradation.
Pfam PF02184: HAT (Half-A-TPR) repeat (repeat)
The HAT (Half A TPR) repeat is found in several RNA processing proteins.
Pfam PF24691: TreTu toxin, C-terminal domain (domain)
This entry represents the C-terminal domain of TreTu from Salmonella enterica and related proteins. TreTu is a part of the TreTu/TriTu toxin/antitoxin system and is involved in the ADP-ribosylation of the EF-Tu GTP-bound form. The C-terminal domain of TreTu adopts a typical ADP-ribosyltransferase fold. The TreTu activity is neutralised by TriTu immunity protein which acts like a lid that closes the TreTu catalytic site and traps the NAD+.
Pfam PF24114: Family of unknown function (DUF7388) (family)
This entry represents uncharacterised archaeal sequences.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF14577: Sieve element occlusion C-terminus (family)
Sieve element occlusion (SEO) proteins, or forisomes, are phloem proteins which accumulate during sieve element differentiation. This domain represents the C-terminus of SEO proteins.
Pfam PF20451: Calmodulin binding protein central domain (domain)
The members of this family are putative or actual calmodulin binding proteins expressed by various plant  species. Some members (for example, [swissprot:Q8H6T7]), are known to be involved in the induction of plant defence responses. However, their precise function in this regards is as yet unknown.
Pfam PF05544: Proline racemase (family)
This family consists of proline racemase (EC 5.1.1.4) proteins which catalyse the interconversion of L- and D-proline in bacteria. This family also contains several similar eukaryotic proteins including [swissprot:Q9NCP4] a sequence with B-cell mitogenic properties which has been characterised as a co-factor-independent proline racemase.
Wikipedia: In enzymology, a proline racemase is an enzyme that catalyzes the chemical reactionL-proline  D-proline
Pfam PF16557: CUT1-like DNA-binding domain of SATB (domain)
CUTL is part of the N-terminal region of SATB proteins, special AT-rich sequence-binding proteins that are global chromatin organisers and gene expression regulators essential for T-cell development and breast cancer tumour growth and metastasis. CUTL carries a DNA-binding region just as CUT domains do.
Pfam PF07130: YebG protein (family)
This family consists of several bacterial YebG proteins of around 75 residues in length. The exact function of this protein is unknown but it is thought to be involved in the SOS response. The induction of the yebG gene occurs as cell enter into the stationary growth phase and is dependent on  is dependent on cyclic AMP and H-NS.