SII-SWORD/CoKE huggingface dataset:
Pfam PF12720: Protein of unknown function (DUF3807) (family)
This is a family of conserved fungal proteins of unknown function.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF07009: NusG domain II (domain)
This domain is found in some NusG proteins where it forms domain II. However most NusG proteins are missing this domain. In other cases this domain is found in isolation. The function of this domain is unknown.
Pfam PF11617: Putative metal-binding motif (repeat)
The seqeunce of structure 2vov is not matched in any other sequence either in UniProt or in NCBI (Sep2014). The model is of a short repeat not found on the G1UBC6 - 2vov - protein. The presence of conserved cysteine residues and the lack of hydrophobic residues suggests that this repeat might be a metal-binding site, perhaps for zinc or calcium ions.
Pfam PF16258: Domain of unknown function (DUF4912) (family)
This family consists of uncharacterized proteins around 160 residues in length and is mainly found in various Clostridium species. The  function of this family is unknown.
Pfam PF22615: Alpha-isopropylmalate synthase, post-catalytic domain-like (domain)
This entry represents domain found in homologues of alpha-isopropylmalate synthase (IPMS). This domain follows the catalytic domain and is required for the enzymatic activity.
Pfam PF07234: Movement and RNA silencing protein (family)
This family consists of several Babuvirus proteins of around 120 residues in length. Proteins in this family include movement and RNA silencing protein (also known as MP) from Banana bunchy top virus. MP acts as a suppressor of RNA-mediated gene silencing, also known as post-transcriptional gene silencing (PTGS), a mechanism of plant viral defense that limits the accumulation of viral RNAs. It transports viral genome to neighbouring plant cells directly through plasmosdesmata, without any budding. The movement protein allows efficient cell to cell propagation, by bypassing the host cell wall barrier.
Pfam PF01583: Adenylylsulphate kinase (domain)
Enzyme that catalyses the phosphorylation of adenylylsulphate to 3'-phosphoadenylylsulfate.  This domain contains an ATP binding P-loop motif.
Wikipedia: In enzymology, an adenylyl-sulfate kinase is an enzyme that catalyzes the chemical reactionATP + adenylyl sulfate  ADP + 3'-phosphoadenylyl sulfate
Pfam PF10249: NADH-ubiquinone oxidoreductase subunit 10 (family)
NDUFB10 is a family of conserved proteins of up to 180 residues. It is one of the 41 protein subunits within the hydrophobic fraction of the NADH:ubiquinone oxidoreductase (complex I), a multiprotein complex located in the inner mitochondrial membrane whose main function is the transport of electrons from NADH to ubiquinone, which is accompanied by translocation of protons from the mitochondrial matrix to the intermembrane space. NDUFB10 is encoded in the nucleus.
Wikipedia: Respiratory complex I, EC 7.1.1.2 is the first large protein complex of the respiratory chains of many organisms from bacteria to humans. It catalyzes the transfer of electrons from NADH to coenzyme Q10 (CoQ10) and translocates protons across the inner mitochondrial membrane in eukaryotes or the plasma membrane of bacteria.
Pfam PF11379: Protein of unknown function (DUF3182) (family)
This family of proteins with unknown function appears to be restricted to Proteobacteria.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF08344: Transient receptor ion channel II (family)
This domain is found in the transient receptor ion channel (Trp) family of proteins.  There is strong evidence that Trp proteins are structural elements of calcium-ion entry channels activated by G protein-coupled receptors.  This domain does not tend to appear with the TRP domain ([pfam:PF06011]) but is often found to the C-terminus of Ankyrin repeats ([pfam:PF00023]).
Pfam PF14656: Rab3 GTPase-activating protein regulatory subunit C-terminus (family)
This family includes the N-terminus of the Rab3 GTPase-activating protein non-catalytic subunit. Rab3 GTPase-activating protein is a GTPase activating protein with specificity for Rab3 subfamily.
Pfam PF19340: Gamma-tubulin complex component 6 N-terminus (family)
This family represents the N-terminal alpha-helical region of Gamma-tubulin complex component 6 (GCP6), a protein indispensable for assembly of the gamma-tubulin complex and for microtubule nucleation. It is located at the centrioles and the pericentriolar material, being required for centriole formation and reduplication. It has been shown that the N-terminal domains define the functional identity of gamma-tubulin complex proteins. GCP6 carries a large internal insertion phosphorylated by Plk4 and contains a domain of interaction with keratins.
Pfam PF07045: Domain of unknown function (DUF1330) (domain)
This family consists of several hypothetical bacterial proteins of around 90 residues in length. The function of this family is unknown.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF13698: Domain of unknown function (DUF4156) (family)
The function of this family is unknown but members are annotated as putative lipoprotein outer membrane proteins.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF08657: DASH complex subunit Spc34 (family)
The DASH complex is a ~10 subunit microtubule-binding complex that is transferred to the kinetochore prior to mitosis. In Saccharomyces cerevisiae DASH forms both rings and spiral structures on microtubules in vitro.  Components of the DASH complex, including Dam1, Duo1, Spc34, Dad1 and Ask1, are essential and connect the centromere to the plus end of spindle microtubules.
Pfam PF08376: Nitrate and nitrite sensing (family)
The nitrate- and nitrite sensing domain (NIT) is found in receptor components of signal transducing pathways in bacteria which control gene expression, cellular motility and enzyme activity in response to nitrate and nitrite concentrations.  The NIT domain is predicted to be all alpha-helical in structure.
Pfam PF24228: Phage tail ring protein 1 (family)
This entry represents the Ring 1 (R1) protein, also known as gp43, which is part of the tail assembly in crassviruses. The R1 protein forms one of five stacked dodecameric rings that make up the tail barrel. These proteins share a conserved fold consisting of two domains: an alpha-helical domain and a beta-sandwich domain. The extended tail barrel formed by these ring proteins is a distinctive feature of crassviruses and may assist the tail muzzle in reaching the outer cell membrane through the compact capsular polysaccharide layer of the host bacteria.
Pfam PF13928: Flocculin type 3 repeat (repeat)
This repeat is found in the Flocculation protein FLO9 [swissprot:P39712] close to its C-terminus.
Pfam PF12030: Domain of unknown function (DUF3517) (family)
This presumed domain is functionally uncharacterised. This domain is found in eukaryotes. This domain is about 340 amino acids in length. This domain is found associated with [pfam:PF00443].
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF24763: CGL160, C-terminal (domain)
This domain is found in Protein CONSERVED ONLY IN THE GREEN LINEAGE 160 from Arabidopsis thaliana (CGL160) and similar proteins from plants and cyanobacteria. CGL160 facilitates the assembly of the membrane proton channel of the chloroplastic F-type ATPase.
Pfam PF11669: WW domain-binding protein 1 (family)
This family of proteins represents WBP-1, a ligand of the WW domain of Yes-associated protein. This protein has a proline-rich domain. WBP-1 does not bind to the SH3 domain.
Pfam PF11970: G protein-coupled glucose receptor regulating Gpa2 C-term (domain)
GPR1 is one of six proteins required for glucose-triggered adenylate cyclase activation, and is a G protein-coupled receptor responsible for the activation of adenylate cyclase through Gpa2 - heterotrimeric G protein alpha subunit, part of the glucose-detection pathway. The protein contains seven predicted transmembrane domains, a third cytoplasmic loop and a cytoplasmic tail. This family is the conserved C-terminal domain of the member proteins.
Pfam PF08525: Opacity-associated protein A N-terminal motif (conserved_site)
This family includes the Haemophilus influenzae opacity-associated protein. This protein is required for efficient nasopharyngeal mucosal colonisation, and its expression is associated with a distinctive transparent colony phenotype. OapA is thought to be a secreted protein, and its expression exhibits high-frequency phase variation. This motif occurs at the N-terminus of these proteins. It contains a conserved histidine followed by a run of hydrophobic residues.
Pfam PF15703: Linker for activation of T-cells family member 2 (family)
The adaptor protein linker activator of T-cells 2 (LAT2), also called non-T-cell activation linker (NTAL), linker activator for B-cells (LAB) or Williams Beuren Syndrome critical region 5 (WBSCR5), is expressed in various myeloid and lymphoid cells . Given the wide expression pattern, it may modulate signalling in most types of leukocytes . It has been shown to be involved in immunoreceptor signaling , B cell activation , negative regulation of T cell activation , and regulation of mast cell physiology .
Wikipedia: Linker for activation of T-cells family member 2 is a protein that in humans is encoded by the LAT2 gene.
Pfam PF01917: Archaebacterial flagellin (family)
Archaeal motility occurs by the rotation of flagella that show similarity to bacterial type IV pili, including the multiflagellin nature of the flagellar filament, N-terminal sequence similarities, as well as the presence of homologous proteins in the two systems. Similar to type IV pilins, archaeal flagellins are initially synthesised with a short leader peptide that is cleaved by a membrane-located peptidase. The enzyme responsible for the removal of the this leader peptide is FlaK. Archaeal flagella are composed of a number of distinct flagellin proteins, specified by genes in two separate operons (A and B).
Pfam PF21071: LARP1 HEAT repeat region (repeat)
This entry represents the HEAT repeat region of the LARP1 protein. La-related protein 1 (LARP1) regulates the stability of many mRNAs. These include 5'TOPs, mTOR-kinase responsive mRNAs with pyrimidine-rich 5' UTRs, which encode ribosomal proteins and translation factors. The repeats within this protein have been called DM15 repeats.
Pfam PF03012: Phosphoprotein (family)
This family includes the M1 phosphoprotein non-structural RNA polymerase alpha subunit, which is thought to be a  component of the active polymerase, and may be involved in template binding.
Pfam PF13177: DNA polymerase III, delta subunit (domain)
DNA polymerase III, delta subunit (EC 2.7.7.7) is required for, along with delta' subunit, the assembly of the processivity factor beta(2) onto primed DNA in the DNA polymerase III holoenzyme-catalysed reaction. The delta subunit is also known as HolA.
Pfam PF16248: Domain of unknown function (DUF4905) (family)
A small family of uncharacterized proteins around 270 residues in length and found in various Cytophagales, Sphingobacteriaceae and Ignavibacteriaceae species. The function of this family is unknown.
Pfam PF18222: PilN biogenesis protein dimerization domain (domain)
This domain is found in PilN type IV pilus biogenesis protein present in Thermus thermophiles. PilN is an integral inner membrane protein needed for the formation of type IV pilus. This domain forms a dimer which is mediated by symmetric contacts between residues in alpha-1, beta-1, beta-3 and alpha-3.
Pfam PF06001: CREB-binding protein/p300, atypical RING domain (domain)
CBP (CREB-binding protein) and p300 (also known as CREBBP or KAT3A and EP300 or KAT3B, respectively) are two histone acetyltransferases (HATs) that associate with and acetylate transcriptional regulators and chromatin. The catalytic core of animal CBP-p300 contains a bromodomain, a CH2 region containing a discontinuous PHD domain interrupted by this RING domain, and a HAT domain. Bromodomain-RING-PHD forms a compact module in which the RING domain is juxtaposed with the HAT substrate-binding site. This RING domain contains only a single zinc ion-binding cluster instead of two; instead of a second zinc atom, a network of hydrophobic interactions stabilizes the domain. The RING domain has an inhibitory role. Disease mutations that disrupt RING attachment lead to upregulation of HAT activity. HAT regulation may require repositioning of the RING domain to facilitate access to an otherwise partially occluded HAT active site. Plant CBP-p300 type HATs lack a bromodomain whose role in the animal animal CBP-p300's is to bind acetylated histones; it has been suggested that these plant proteins may utilise a different domain or another bromodomain protein to perform this function. This RING domain has also been referred to as DUF902.
Pfam PF08009: CDP-alcohol phosphatidyltransferase 2 (domain)
This domain is found on CDP-alcohol phosphatidyltransferases. These enzymes catalyse the displacement of CMP from a CDP-alcohol by a second alcohol with formation of a phosphodiester bond and concomitant breaking of a phosphoride anhydride bond.
Pfam PF05199: GMC oxidoreductase (domain)
This domain found associated with [pfam:PF00732].
Wikipedia: In molecular biology, the glucose-methanol-choline oxidoreductase family is a family of enzymes with oxidoreductase activity.
Pfam PF15808: BCL-6 co-repressor, non-ankyrin-repeat region (family)
BCOR is a domain family found in eukaryotes, and is approximately 220 amino acids in length. This domain lies just upstream of the ankyrin-repeat region at the C-terminus of BCL-6 co-repressor proteins. The function of this region is not known.
Pfam PF12808: Micro-tubular organiser Mto1 C-term Mto2-binding region (coiled_coil)
The C-terminal region of the micro-tubular organiser protein 1 (mto1) is the binding domain for attachment to Mto2p.The full-length Mto1 protein is required for microtubule nucleation from non-spindle pole body MTOCs in fission yeast. The interaction of Mto2p with this region of Mto1 is critical for anchoring the cytokinetic actin ring to the medial region of the cell and for proper coordination of mitosis with cytokinesis.
Pfam PF16804: Domain of unknown function (DUF5071) (repeat)
The function of DUF5071 is not known. This domain adopts a right-handed superhelix assembled from eight, repeated in tandem, Î±-helices 3ut4 .
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF03057: DUF236 repeat (repeat)
This family represents a short repeat region found a number of C. elegans proteins of unknown function.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF13217: Protein of unknown function (DUF4025) (family)
This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 60 amino acids in length. There is a conserved EGT sequence motif.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF24654: CEP76 N-terminal domain (domain)
This entry represents a domain found at the N-terminal of centrosomal protein of 76 kDa, a protein involved in regulation of centriole duplication to limit centriole duplication to once per cell cycle by preventing centriole reduplication.
Pfam PF14076: Domain of unknown function (DUF4258) (domain)
This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria, archaea and eukaryotes. Proteins in this family are typically between 95 and 124 amino acids in length.  Structural models show this family adopts a structure found in bacterial toxins, suggesting this family are the toxins in a toxin-antitoxin system.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF17253: Family of unknown function (DUF5320) (family)
A number of this family members have a coiled coil domain at the C terminal.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF09905: DNA-binding protein VF530 (family)
VF530 contains a unique four-helix motif that shows some similarity to the C-terminal double-stranded DNA (dsDNA) binding domain of RecA, as well as other nucleic acid binding domains.
Pfam PF20900: Pasteurella multocida toxin, C3 domain (domain)
Pasteurella multocida toxin (PMT) inhibits osteoblastic differentiation in mammals and birds. Its N-terminal region binds to target cells, while its C-terminal region, with a Trojan horse-like shape, carries the intracellularly active moiety. The latter consists of three distinct domains: C1 ([pfam:PF11647]), C2 and C3. This entry represents the C-terminal catalytic domain C3, which has a Cys-His-Asp triad known to perform acyl-hydrolysis such as peptidase activity or an acyl-transfer reaction. This domain adopts a typical alpha-beta protein fold with seven beta-strands and eight helices. It is organised into two subdomains that form the the biologically active cleft space.
Pfam PF14203: Putative transposon-transfer assisting protein (family)
TTRAP is a family of small bacterial proteins largely from Clostrium difficile. From comparative and other structural studies of the PDB:2L7K, UniProtKB:Q18AW3, it has been suggested that this family is required for interacting with other proteins in order to facilitate the transfer of the transposon CTn4 between different bacterial species. PDB:2L7K comprises an alpha-helical fold of four alpha-helices leading to the production of two clefts, the larger of which displays two highly conserved residues in close proximity, Glu-8 and Lys-48. The gene concerned is part of an operon within transposon CTn4, and is expressed alongside a putative DNA primase, a DNA topoisomerase and conjugal transfer proteins.
Pfam PF02610: L-arabinose isomerase N-terminal domain (domain)
This entry represents a domain found N-terminal in L-arabinose isomerases, AraA, [ec:5.3.1.4]. These enzymes catalyse the reaction: L-arabinose  L-ribulose. This reaction is the first step in the pathway of L-arabinose utilisation as a carbon source after entering the cell L-arabinose is converted into L-ribulose by the L-arabinose isomerases enzyme. The domain represented by this entry is composed of a central parallel beta-sheet packed with alpha-helices on both sides and with topology similar to the topology of the middle domain.
Wikipedia: In enzymology, a L-arabinose isomerase is an enzyme that catalyzes the chemical reactionL-arabinose  L-ribulose
Pfam PF17879: DNA ligase C-terminal domain (domain)
This is the C-terminal domain found in ATP-Dependent DNA Ligase from Bacteriophage T7. This domain has no ligase activity, however together with the N-terminal domain they bind to double-stranded DNA consistent with the idea that the DNA-binding site is between the domains in the intact protein. Furthermore, although the fold of domain 2 is very similar to a number of other proteins that bind single-stranded DNA, this domain does not bind to single-stranded DNA but instead has a high affinity for double-stranded DNA.
Pfam PF24928: Domain of unknown function (DUF7748) (domain)
This domain is found in uncharacterised proteins from plants. It is predicted to fold into a beta-sandwich.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF10016: Predicted secreted protein (DUF2259) (family)
Members of this family of hypothetical bacterial proteins have no known function.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.