SII-SWORD/CoKE huggingface dataset:
Pfam PF17313: Family of unknown function (DUF5359) (family)
This is a family of unknown function found in Bacillales.  Most of the family members are predicted to have one trans-membrane region.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF01987: Mitochondrial biogenesis AIM24 (family)
In eukaryotes, this domain is involved in mitochondrial biogenesis. Its function in prokaryotes in unknown.
Pfam PF07707: BTB And C-terminal Kelch (domain)
This domain is found associated with [pfam:PF00651] and [pfam:PF01344]. The BACK domain is found juxtaposed to the BTB domain; they are  separated by as little as two residues. This family appears to be closely related to the BTB domain (Finn RD, personal observation).
Pfam PF02548: Ketopantoate hydroxymethyltransferase (family)
Ketopantoate hydroxymethyltransferase ([ec:2.1.2.11]) is the first enzyme in the pantothenate biosynthesis pathway.
Pfam PF24636: Domain of unknown function (DUF7633) (domain)
This presumed domain is found at the C-terminal of uncharacterised sequences from diatoms, which is usually associated with a beta-solenoid at the N-terminal. This domain may adopt a beta-sandwich fold.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF14639: Holliday-junction resolvase-like of SPT6 (domain)
The YqgF domain of SPT6 proteins is homologous to the E.coli RuvC but its putative catalytic site lacks the carboxylate side chains critical for coordinating magnesium ions that mediate phosphodiester bond-cleavage
Pfam PF23354: NUP160/120 middle TPR (repeat)
This entry represents a segment of TPRs found in the middle region of nucleoporin Nup160 from human, mouse, Drosophila and Arabidopsis thaliana, as well as in the homologues from yeast, Nucleoporin 120 (Nup120). NUP160 depletion could restore autophagy and inhibit fibrosis and inflammatory response in high glucose-treated. The Arabidopsis Nup160, a scaffold Nup, is important for regulating the floral transition, a key developmental phase change in flowering plants, through modulating the subcellular localization of HOS1 at NPCs. Nup120 is part of a Nuclear Pore Complex (NPC) as a component of the ctNup84 complex.
Pfam PF19932: Family of unknown function (DUF6395) (family)
This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0000755) is described by MIBiG as an example of the following biosynthetic class, saccharide, in particular the capsular polysaccharide biosynthetic gene cluster from Avibacterium paragallinarum 221. This family appears to be predominantly found in Actinobacteria and Firmicutes.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF21859: Replitron, HUH endonuclease domain (domain)
This entry represents the Rep HUH endonuclease domain of the eukaryotic transposase encoded by replitrons, a fourth independent group of DNA transposons found in genomes of green algae and plants, diverse stramenopiles including brown seaweeds and likely also cryptophytes and haptophytes, which suggests an ancient origin and broad eukaryotic distribution. This domain contains motif I (SUTU), motif II (HUQ) and motif III (YxxK), the latter including the catalytic tyrosine residue. There is also a conserved Glu upstream of motif II, which may represent the third metal-binding ligand, analogous to those in the Reps of CRESS-DNA virus PCV2 or Helraiser Helitron.
Pfam PF01972: ClpP-like SDH-type serine proteinase (family)
This family of archaebacterial proteins, formerly known as DUF114, has been found to be a serine proteinase distantly related to ClpP proteinases that belong to the serine proteinase superfamily. The family has a catalytic triad of Ser, Asp, His residues in a linear sequential arrangement (SDH), which shows an altered residue ordering compared with the classical ClpP proteinases (SHD) but similar to that of the carboxypeptidase clan.
Pfam PF04925: SHQ1 protein, Shq1 domain (domain)
This domain is found at the C-terminal end of Protein SHQ1 homolog from humans and similar eukaryotic proteins. SHQ1 is a factor required for the biogenesis and assembly of H/ACA small nucleolar ribonucleoparticle (snoRNP), which are essential for ribosomal RNA and telomerase RNA processing and metabolism. This protein contains two domains: an N-terminal CS or HSP20-like domain ([pfam:PF21413]) and a C-terminal region called the Shq1 domain (this entry). This domain adopts a mostly helical structure that consists of 17 alpha-helices and two short beta-strands.
Pfam PF08102: Scorpion antimicrobial peptide (family)
This family consists of antimicrobial peptides secreted by scorpions. Novel antimicrobial peptides have been isolated from scorpions, namely the opistoporin and the pandinin. These peptides form essentially helical structures and demonstrate high antimicrobial activity against Gram-negative and Gram-positive bacteria respectively.
Pfam PF24488: Domain of unknown function (DUF7584) (domain)
This is an Ig-like domain found in the middle region of a group of uncharacterised sequences from nematodes.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF01752: Collagenase (family)
This family of enzymes break down collagens.
Wikipedia: Collagenases are enzymes that break the peptide bonds in collagen. They assist in destroying extracellular structures in the pathogenesis of bacteria such as Clostridium. They are considered a virulence factor, facilitating the spread of gas gangrene. They normally target the connective tissue in muscle cells and other body organs.
Pfam PF14795: Leucine-tRNA synthetase-specific domain (domain)
This short region is found only in leucyl-tRNA synthetases. It is flexibly linked to the enzyme-core by beta-ribbons structures
Pfam PF02532: Photosystem II reaction centre I protein (PSII 4.8 kDa protein) (family)
This family consists of various Photosystem II (PSII) reaction centre I proteins or PSII 4.8 kDa proteins, PsbI, from the chloroplast genome of many plants and Cyanobacteria. PsbI is a small, integral membrane component of PSII the role of which is not clear.  Synechocystis mutants lacking  PsbI have 20-30% loss of PSII activity however the PSII complex is not destabilised.
Pfam PF12269: CpG binding protein C-terminal domain (domain)
CpG-binding protein is a transcriptional activator that exhibits a DNA binding specificity for unmethylated CpG motifs. CpG is made of a PHD1, an acidic, a basic, a coiled-coil, and a PHD2 domains. This protein contains three cysteine-rich domains identified at the N-terminal, central region and C-terminal of the protein, where the central cysteine-rich domain is located within the DNA-binding domain, found between PHD1 and the acidic domains. This domain is found in eukaryotes, and is approximately 240 amino acids in length. It is found at the C-terminal of the CpG-binding protein containing the coiled-coil and PHD2 domains.
Pfam PF21956: Family of unknown function (DUF6922) (family)
This family is found in bacterial proteins either as a standalone domain or in combination with an HTH domain that resembles lambda C1 repressor DNA-binding domain. This family has a partial sequence similarity to the RAP1 C-terminal (RCT) domain.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF04599: Poxvirus G5 protein (family)
This protein has been predicted to be related to the FEN-1 endonuclease.
Pfam PF16521: Myosin VI cargo binding domain (domain)
Myosin-VI_CBD is a C-terminal family that allows unconventional myosin-VI to recognise and select its binding cargoes. Several adaptor proteins have been reported to interact specifically with the CBD, thus defining the specific subcellular functions of myosin VI. The crystal structure determination of the myosin VI CBD/Dab2 (an endocytic adaptor protein Disabled-2 that is a cargo) complex shows that the Myosin-VI_CBD forms a cargo-induced dimer, suggesting that the motor undergoes monomer-to-dimer conversion that is dependent upon cargo binding. In the absence of cargo myosin VI exists as a stable monomer. This cargo binding-mediated monomer-to-dimer conversion mechanism adopted by myosin VI may be shared by other unconventional myosins, such as myosin VII and myosin X.
Pfam PF08427: Armadillo-like helical domain-containing protein 3, C-terminal (domain)
This is the C-terminal domain of Armadillo-like helical domain- containing protein 3 (ARMH3), the previously uncharacterised peripheral Golgi protein C10orf76. ARMH3 interacts with and is involved in GBF1 recruitment, Golgi maintenance and protein secretion. The function of this domain is unknown.
Pfam PF05340: Protein of unknown function (DUF740) (family)
This family consists of several uncharacterised plant proteins of unknown function.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF04245: 37-kD nucleoid-associated bacterial protein (family)
The Escherichia coli nucleoid contains DNA in a condensed but functional form. Analysis of proteins released from isolated spermidine nucleoids after treatment with DNase I revealed significant amounts of two proteins not previously detected in wild-type E. coli. Partial amino-terminal sequencing has identified them as the products of rdgC and yejK. These proteins are strongly conserved in Gram-negative bacteria, suggesting that they have important cellular roles .

This entry represents the product of gene yejK, nucleoid associated protein NdpA.
Pfam PF20179: MSS51 C-terminal domain (domain)
This presumed domain is found at the C-terminus of the MSS51 protein.
Pfam PF14251: PterinBD-DUF4346 (domain)
This domain is found in bacteria, archaea and a few lower eukaryotes species. There are two conserved sequence motifs: LDP and DHA. Many members of this family have been annotated as dihydropteroate synthases, however no experimental evidence can be found for this and [swissprot:Q57571] has been shown not to possess dihydropteroate synthase activity. In bacteria, this domain is found in predicted conflict systems that also encode genes for an active Thymidylate synthase and a pterin-dependent one-carbon carrier (MtrA domain). This system is predicted to deplete virally generated nucleotides and replace them with a nucleotide that restricts invasive DNA or protects host DNA.
Pfam PF20205: Family of unknown function (DUF6567) (family)
This family of proteins is functionally uncharacterised. This family of proteins is found mainly in Bacteroidetes. Proteins in this family are approximately 120 amino acids in length. There is a conserved motif NF/Y and two conserved residues, a Cys and an Asn.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF14748: Pyrroline-5-carboxylate reductase dimerisation (domain)
Pyrroline-5-carboxylate reductase consists of two domains, an N-terminal catalytic domain ([pfam:PF03807]) and a C-terminal dimerisation domain. This is the dimerisation domain.
Pfam PF05015: RelE-like toxin of type II toxin-antitoxin system HigB (domain)
This family carries several different examples of type II bacterial toxins of toxin-antitoxin systems including many HigB-like ones. The fold is referred to as the RelE/YoeB/Txe/Yeeu fold suggesting all examples of these are present in this family. Several plasmids with proteic killer gene-systems have been reported.  All of them encode a stable toxin and an unstable antidote. Upon loss of the plasmid, the less stable inhibitor is inactivated more rapidly than the toxin, allowing the toxin to be activated. The activation of these systems results in cell filamentation and cessation of viable cell production. It has been verified that both the stable killer and the unstable inhibitor of the systems are short polypeptides. This family corresponds to the toxin.
Wikipedia: A toxin-antitoxin system consists of a "toxin" and a corresponding "antitoxin", usually encoded by closely linked genes. The toxin is usually a protein while the antitoxin can be a protein or an RNA. Toxin-antitoxin systems are widely distributed in prokaryotes, and organisms often have them in multiple copies. When these systems are contained on plasmids – transferable genetic elements – they ensure that only the daughter cells that inherit the plasmid survive after cell division. If the plasmid is absent in a daughter cell, the unstable antitoxin is degraded and the stable toxic protein kills the new cell; this is known as 'post-segregational killing' (PSK).
Pfam PF05394: Avirulence protein (family)
This family consists of several avirulence proteins from Pseudomonas syringae and Xanthomonas campestris.
Pfam PF08840: BAAT / Acyl-CoA thioester hydrolase C terminal (domain)
This catalytic domain is found at the C terminal of acyl-CoA thioester hydrolases and bile acid-CoA:amino acid N-acetyltransferases (BAAT).
Pfam PF00611: Fes/CIP4, and EFC/F-BAR homology domain (family)
Alignment extended from. Highly alpha-helical.  The cytosolic endocytic adaptor proteins in fungi carry this domain at the N-terminus; several of these have been referred to as muniscin proteins. These N-terminal BAR, N-BAR, and EFC/F-BAR domains are found in proteins that regulate membrane trafficking events by inducing membrane tubulation. The domain dimerises into a curved structure that binds to liposomes and either senses or induces the curvature of the membrane bilayer to cause biophysical changes to the shape of the bilayer; it also thereby recruits other trafficking factors, such as the GTPase dynamin. Most EFC/F-BAR domain-family members localise to actin-rich structures.
Pfam PF15074: Cilia and flagella associated protein 90 (family)
This family represents the homologues of Cilia and flagella associated protein 90 (CFAP90, also known as C5orf49). CFAP90 is a microtubule inner protein (MIP) part of the doublet microtubules (DMTs) in cilia and sperm axoneme. It belongs to the core-MIPs and binds to protofilament B09 in the sperm DMTs. Members of this family contain a conserved KLHRDDR sequence motif.
Pfam PF04434: SWIM zinc finger (domain)
This domain is found in bacterial, archaeal and eukaryotic proteins. It is predicted to be organised into two N-terminal beta-strands and a C-terminal alpha helix, thus possibly adopting a fold similar to that of the C2H2 zinc finger ([pfam:PF00096]). SWIM is thought to be a versatile domain that can interact with DNA or proteins in different contexts.
Pfam PF08966: Domain of unknown function (DUF1882) (domain)
This domain is found in a set of hypothetical bacterial proteins.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF21271: Sortin nexin 17/31, FERM domain, F2 lobe (domain)
Sortin nexin 17/31 are known as PX-FERM proteins, a sub-group of the PX superfamily that contain a defining PtdInsP-binding PX domain, and a C-terminal 4.1, ezrin, radixin, moesin (FERM) domain. They are modular peripheral membrane proteins that act as central scaffolds mediating protein-lipid interactions, cargo binding, and regulatory protein recruitment. The FERM domain omprises three lobes termed F1, F2, and F3: F1 adopts a ubiquitin-like fold, F2 is a helical structure similar to acyl-CoA binding protein, and F3 is similar to the phosphotyrosine binding (PTB)/pleckstrin homology domain and referred to as atypical FERM domain ([pfam:PF18116]). This entry represents the F2 lobe.
Pfam PF20522: Domain of unknown function (DUF6737) (domain)
This presumed domain is functionally uncharacterised. This domain is approximately 57 amino acids in length.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF03154: Atrophin-1 family (disordered)
Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteristic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.
Pfam PF24823: RDR2 PH-like domain (domain)
This domain is found in RNA-dependent RNA polymerase 2 (RDR2) from Arabidopsis thaliana and related proteins. RDR2 is involved in the production of small interfering RNAs (siRNAs). It binds to single-stranded RNA (ssRNA), engages ssRNAs longer than 7 nucleotides and initiates internal to their 3' ends. RDR2 is non-functional in the absence of associated Pol IV. The domain represented by this entry adopts a beta-barrel structure with significant similarity to known PH domains.
Pfam PF18088: Glycoside Hydrolase 20C C-terminal domain (domain)
This is the C-terminal domain of Glycoside hydrolase 20 C (GH20C) present in S. pneumoniae. GH20C possesses the ability to hydrolyze the beta-linkages joining either N-acetylglucosamine or N-acetylgalactosamine to a wide variety of aglycon residues. The C-terminal domain is commonly known as Domain III is important in dimerization as it forms the primary interface of the dimer. However, there is presently no evidence supporting dimerization as being necessary for catalysis. Domain III is unusual among structurally characterized GH20 enzymes but in GH20 enzymes possessing domain III, dimerization seems to be a conserved feature.
Pfam PF17710: Family of unknown function (DUF5555) (family)
This is a family of unknown function found in mammals.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF14988: Domain of unknown function (DUF4515) (family)
This family of proteins is found in bacteria and eukaryotes. Proteins in this family are typically between 198 and 469 amino acids in length. There are two completely conserved L residues that may be functionally important.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF14556: AF2331-like protein (domain)
AF2331-like is a 11-kDa orphan protein of unknown function from Archaeoglobus fulgidus. The structure consists of an alpha + beta fold formed by an unusual homodimer, where the two core beta-sheets are interdigitated, containing strands alternating from both subunits. AF2331 contains multiple negatively charged surface clusters and is located on the same operon as the basic protein AF2330. It is suggested that AF2331 and AF2330 may form a charge-stabilized complex in vivo, though the role of the negatively charged surface clusters is not clear.
Pfam PF08158: SDA1, HEAT repeat (repeat)
SDA1 is a HEAT repeat-containing protein required for 60S pre-ribosomal subunits export to the cytoplasm and may also be required for 60S ribosomal subunit maturation and accumulation. This entry represents the N-terminal domain of SDA1 proteins (also referred to as NUC130), which consists of HEAT repeats.
Pfam PF07380: Pneumovirus M2 protein (family)
This family consists of several Pneumovirus M2 proteins. The M2-1 protein of respiratory syncytial virus (RSV) is a transcription processivity factor that is essential for virus replication.
Pfam PF23642: YnhH-like (family)
This protein family includes Protein YnhH from Escherichia coli, a 64-residues long microprotein encoded by a small open reading frame (smORF).