SII-SWORD/CoKE huggingface dataset:
Pfam PF24284: Family of unknown function (DUF7472) (family)
This family includes a group of short proteins from archaea. Members are predicted to adopt an alpha-helical structure.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF23556: Vps41 TPR-like region (repeat)
This entry represents the central TPR-like region of Vps41 proteins.  The VPS41 family is involved in vesicle-mediated protein trafficking to lysosomal compartments, including endocytic membrane transport and autophagic pathways. Members of the VPS41 family are believed to act as core components of the putative HOPS and CORVET endosomal tethering complexes, which are essential for the conversion of early endosomes to late endosomes, implicating specific Rab GTPases in the process. They are involved in tethering and docking events during SNARE-mediated membrane fusion, and regulate endocytic, phagocytic, and autophagic traffic towards lysosomes. The family plays a role in the fusion of autophagosomes with lysosomes and may be involved in sorting to the regulated secretory pathway. Additionally, VPS41 proteins contribute to the normal development of certain cellular structures in some organisms and may have a role in the negative regulation of apoptosis. They are also required for the uptake of exogenous dsRNA in experimental RNA silencing.
Pfam PF04091: Exocyst complex subunit Sec15 C-terminal (repeat)
Sec15 is a component of the exocyst complex involved in the tethering of post-Golgi Golgi secretory vesicles to the plasma membrane during exocytosis and plays a role in several cellular functions such as cell polarisation, cytokinesis, ciliogenesis and tumour invasion. The exocyst is one of the  members of the complexes associated with tethering containing helical rods (CATCHR), together with COG, GARP, and Dsl1 complexes, which share a fold consisting of alpha-helical bundles forming a rod structure. This is the C-terminal domain of Sec15 which mediates Rab GTPases binding in a GTP-dependent manner.
Pfam PF18740: EC042_2821-like Restriction Endonuclease-like domain (domain)
This entry represents a Restrictions Endonuclease-like fold fused to a HEPN-like domain [pfam:PF12358] (EC042_2821).
Pfam PF19787: Family of unknown function (DUF6271) (family)
This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0000093) is described by MIBiG as an example of the following biosynthetic class, polyketide, in particular the meilingmycin biosynthetic gene cluster from Streptomyces nanchangensis. This family appears to be predominantly found  in bacteria.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF21080: Virus-capping methyltransferase, connector domain (domain)
This is the connector domain (CD) from Mononegavirales single-stranded RNA viral RNA polymerase enzymes (L proteins). This domain flanks the methyltransferase domain (MT, [pfam:PF14314]) and together with the C-terminal domain (CTD), in conjunction with its phosphoprotein cofactor, likely facilitates the structural rearrangements that appear to coordinate the enzymatic activities during transcription and replication.
Pfam PF11705: DNA-directed RNA polymerase III subunit Rpc31 (family)
RNA polymerase III contains seventeen subunits in yeasts and in human cells. Twelve of these are akin to RNA polymerase I or II and the other five are RNA pol III-specific, and form the functionally distinct groups (i) Rpc31-Rpc34-Rpc82, and (ii) Rpc37-Rpc53. Rpc31, Rpc34 and Rpc82 form a cluster of enzyme-specific subunits that contribute to transcription initiation in S.cerevisiae and H.sapiens. There is evidence that these subunits are anchored at or near the N-terminal Zn-fold of Rpc1, itself prolonged by a highly conserved but RNA polymerase III-specific domain.
Pfam PF10733: Protein of unknown function (DUF2525) (family)
This family of proteins with unknown function appears to be restricted to Enterobacteriaceae. The family has a highly conserved sequence.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF19342: MGP3 C-terminal domain (domain)
This entry represents the C-terminal domain from the Mycoplasma genitalium p110 adhesin protein. This domain has an Ig fold. It is adjacent to the membrane. This domain contains a bound potassium ion.
Pfam PF09843: Predicted membrane protein (DUF2070) (family)
This is a family of Archaeal 7-TM proteins. There are 6 closely assembled TM-regions at the N-terminus followed by a long intracellular, from residues 220-590, highly conserved region, of unknown function, terminating with one more TM-region. The short 25 residue section between TMs 5 and 6 might lie on the outer surface of the membrane and be acting as a receptor (from TMHMM).
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF07628: Protein of unknown function (DUF1589) (family)
A family of short hypothetical proteins in Rhodopirellula baltica.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF05648: Peroxisomal biogenesis factor 11 (PEX11) (family)
This family consists of several peroxisomal biogenesis factor 11 (PEX11) proteins from several eukaryotic species. The PEX11 peroxisomal membrane proteins promote peroxisome division in multiple eukaryotes.
Wikipedia: Peroxisomal biogenesis factor 11 (PEX11)  are peroxisomal membrane proteins which promote peroxisome division in eukaryotic cells.
Pfam PF16050: Paf1 complex subunit CDC73 N-terminal (family)
CDC73_N is the N-terminal region of the members of CDC73_C, [pfam:PF05179]. CDC73 forms part of the Paf1 post-initiation complex. The exact function within the complex is not known.
Pfam PF22745: DNA ligase-like, N-terminal NAD+-binding domain (domain)
The alpha-helical Nlig-Ia domain is found at the N-terminal of DNA ligases and it has been proposed to either swivel the NAD+ close to the ligase active site lysine on the RAGNYA domain or function as an allosteric NAD+ binding site. The Nlig-Ia domain is also observed as a solo protein in phages that do not encode a separate NAD+-dependent ligase catalytic  module, suggesting the domain can function independently of a DNA ligase. It has been proposed that these domains likely function as NAD+ sensors which might help indicate to the phage the development of NADase host effectors or shield NAD+ from the action of such effectors.
Pfam PF14703: Cytosolic domain of 10TM putative phosphate transporter (domain)
PHM7_cyt is the predicted cytosolic domain of integral membrane proteins, such as yeast PHM7 and TM63A_HUMAN TRANSMEMBRANE PROTEIN 63A, SwissProt:O94886. This domain usually precedes the 7TM region, [pfam:PF02714], and follows a RSN1_TM, [pfam:PF13967]. Fold recognition programs consistently and with high significance predict this domain to be distantly homologous to RNA binding proteins from the RRM clan.
Pfam PF11148: Protein of unknown function (DUF2922) (family)
This bacterial family of proteins has no known function.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF05541: Entomopoxvirus spheroidin protein (family)
Entomopoxviruses (EPVs) are large (300-400 nm) oval-shaped viruses replicating in the cytoplasm of their insect host cells. At the end of their replicative cycle EPVs virions are occluded in a highly expressed protein called spheroidin. This protein forms large (5-20 mm long) oval-shaped occlusion bodies (OBs) called spherules. The infectious cycle of EPVs begins with the ingestion by the insect host of the spherules, their dissolution by the alkaline reducing conditions of the midgut fluid and the release of virions in the midgut lumen. The infective particles first replicate in midgut epithelial cells, then pass the gut barrier to colonise the internal tissues, mainly the fat body cells. Whilst spheroidin has been demonstrated to be non-essential for viral replication, it plays an essential role in the natural biological cycle of the virus in protecting virions from adverse environmental conditions (e.g. UV degradation) and thus improving transmission efficacy. In this respect, spheroidins are functionally similar to polyhedrins of baculoviruses or cypoviruses.
Pfam PF02814: UreE urease accessory protein, N-terminal domain (domain)
UreE is a urease accessory protein. Urease [pfam:PF00449] hydrolyses  urea into ammonia and carbamic acid.
Pfam PF11645: PD-(D/E)XK endonuclease (domain)
This family of endonucleases includes a group I intron-encoded endonuclease. This family belongs to the PD-(D/E)XK superfamily.
Pfam PF15538: Bacterial toxin 46 (family)
A predicted toxin domain found in bacterial polymorphic toxin systems. The toxin possesses an alpha+beta fold with a conserved glutamine residue and a [KR]STxxPxxDxx[ST] motif. In bacterial polymorphic toxin systems, the toxin is exported by the type 2 or type 6 secretion system.
Pfam PF13155: Toprim-like (family)
This is a family or Toprim-like proteins.
Pfam PF15115: Domain of unknown function with conserved HDNR motif (family)
This family of proteins is found in eukaryotes. Proteins in this family are typically between 117 and 219 amino acids in length. There is a conserved HDNR sequence motif. The function is not known.
Pfam PF16228: Domain of unknown function (DUF4887) (disordered)
This family consists of uncharacterised proteins around 210 residues in length and is mainly found in various Staphylococcus species. The function of this family is unknown.
Pfam PF10143: 2,3-bisphosphoglycerate-independent phosphoglycerate mutase (family)
This family represents 2,3-bisphosphoglycerate-independent phosphoglycerate mutase (iPGAM), a metalloenzyme found particularly in archaea and some eubacteria, which catalyses the interconversion of 2-phosphoglycerate and 3-phosphoglycerate in the reaction: [(2R)-2-phosphoglycerate = (2R)-3-phosphoglycerate] (EC 5.4.2.12).
Pfam PF19868: Family of unknown function (DUF6341) (family)
This family of uncharacterised proteins is found in bacteria. Proteins in this family are approximately 70 amino acids in length. There are two conserved sequence motifs, WIF and YW. Probably, they are Uracil phosphoribosyltransferases.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF16025: Calcium-dependent calmodulin binding (family)
This domain is found at the N-terminus of centriolar coiled-coil protein of 110 kDa (CCP110), where it binds calmodulin. Binding of calmodulin to this domain is calcium dependent.
Pfam PF12601: Rubivirus non-structural protein (family)
This domain family is found in viruses, and is approximately 70 amino acids in length. The family is found in association with [pfam:PF05407]. The rubella virus (RUB) nonstructural (NS) protein (NSP) ORF encodes a protease that cleaves the NSP precursor (240 kDa) at a single site to produce two products.
Pfam PF17368: Spore morphogenesis and germination YwcE (family)
The ywcE gene codes for a holin-like protein that localizes to the cell and spore membranes. It is expressed at the onset of sporulation and transcription is repressed during growth by the transition-state regulator AbrB. YwcE is an 83-residue protein with three trans-membrane regions and a highly charged C-terminal tail. Moreover, YwcE has a dual start motif, which plays a role in the regulation of class I or class II holins. It is likely to have the N terminus on the outside of the membrane and the C terminus in the cytoplasm. This family is found in YwcE proteins in Bacilli.
Pfam PF23517: TCERG1 WW domain (domain)
This entry corresponds to the C-terminal WW domain.  The Transcription Elongation Regulator 1 (TCERG1) family comprises proteins that play a critical role in the regulation of transcription elongation. Members of the TCERG1 family are known to bind RNA polymerase II and inhibit the elongation of transcripts from target promoters. They are involved in the regulation of transcription elongation in a TATA box-dependent manner and are necessary for TAT-dependent activation of the HIV-1 promoter. The family is characterized by the presence of FF domains, which bind the phosphorylated C-terminus of RNA polymerase II and mediate interactions with other proteins such as HTATSF1. These domains also show a preference for peptides with a specific consensus sequence.  Additionally, the WW domains within these proteins are responsible for binding to Pro-rich domains, facilitating further protein-protein interactions.
Wikipedia: The WW domain is a modular protein domain that mediates specific interactions with protein ligands. This domain is found in a number of unrelated signaling and structural proteins and may be repeated up to four times in some proteins. Apart from binding preferentially to proteins that are proline-rich, with particular proline-motifs, [AP]-P-P-[AP]-Y, some WW domains bind to phosphoserine- and phosphothreonine-containing motifs.
Pfam PF05523: WxcM-like, C-terminal (domain)
This family includes FdtA ([swissprot:Q6T1W8]) from Aneurinibacillus thermoaerophilus, which has been characterised as a dtdp-6-deoxy-3,4-keto-hexulose isomerase. It also includes WxcM ([swissprot:Q93S92]) from Xanthomonas campestris (pv. campestris).
Pfam PF06103: Bacterial protein of unknown function (DUF948) (family)
This family consists of bacterial sequences several of which are thought to be general stress proteins.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF11999: Ice-binding-like (family)
This family includes members found in bacteria, fungi and archaea, many of which are ice-binding proteins (IBPs). In Antarctic  bacterium Flavobacterium frigoris PS1, FfIBP is an ice-binding  protein that inhibits ice growth through direct interaction with  ice crystals to permit the survival of polar organisms in extremely  cold environments. In arctic yeast Leucosporidium sp, LeIBP,  an ice-binding protein, can lower the freezing point below the  melting point once it binds to ice. Family members also have a  single completely conserved glycine residue that may be functionally  important.
Wikipedia: Antifreeze proteins (AFPs) or ice structuring proteins refer to a class of polypeptides produced by certain animals, plants, fungi and bacteria that permit their survival in temperatures below the freezing point of water. AFPs bind to small ice crystals to inhibit the growth and recrystallization of ice that would otherwise be fatal. There is also increasing evidence that AFPs interact with mammalian cell membranes to protect them from cold damage. This work suggests the involvement of AFPs in cold acclimatization.
Pfam PF00437: Type II/IV secretion system protein (domain)
This entry contains both Type II protein secretion system (T2SS), including Type 4 pilus (T4P), and Type IV protein secretion system (T4SS) from Gram-negative bacteria. [swissprot:P07169] VirB11 ATPase is a subunit of the Agrobacterium tumefaciens transfer DNA (T-DNA) transfer system, a type IV secretion pathway required for delivery of T-DNA and effector proteins to plant cells during infection. The cytoplasmic T2S E ATPase is a Zn-containing protein thought to provide the mechanical force for the secretion process. T2S-E contains Walker A and B motifs, that are essential for secretion and ATPase activity. ATPase PulE and XcpR from Klebsiella oxytoca and Pseudomonas aeruginosa respectively are required for protein secretion via the T2SS. ATPase PilB is required for T4P extension. The type II protein secretion system (T2SS) is a sophisticated  multi-protein machinery containing 12-15 different proteins.  Historically, this system was described as the main terminal branch  (MTB) of the general secretory pathway (GSP), but this nomenclature  is now on obsolete.
Pfam PF03925: SeqA protein C-terminal domain (domain)
The binding of SeqA protein to hemimethylated GATC sequences is important in the negative modulation of chromosomal initiation at oriC, and in the formation of SeqA foci necessary for Escherichia coli chromosome segregation. SeqA tetramers are able to aggregate or multimerise in a reversible, concentration-dependent manner. Apart from its function in the control of DNA replication, SeqA may also be a specific transcription factor.
Wikipedia: In molecular biology the SeqA protein is found in bacteria and archaea. The function of this protein is highly important in DNA replication. The protein negatively regulates the initiation of DNA replication at the origin of replication, in Escherichia coli, OriC. Additionally the protein plays a further role in sequestration. The importance of this protein is vital, without its help in DNA replication, cell division and other crucial processes could not occur. This protein domain is thought to be part of a much larger protein complex which includes other proteins such as SeqB.
Pfam PF03134: TB2/DP1, HVA22 family (family)
This family includes members from a wide variety of eukaryotes. It includes the TB2/DP1 (deleted in polyposis) protein  (e.g. [swissprot:Q00765]), which in humans is deleted in severe forms of familial adenomatous polyposis, an autosomal dominant oncological inherited disease. The family also includes the plant protein of known similarity to TB2/DP1, the HVA22 abscisic acid-induced protein (e.g. [swissprot:Q07764]), which is thought to be a regulatory protein.
Pfam PF08301: Hepatitis C virus non-structural 5a domain 1b (domain)
The molecular function of the non-structural 5a protein is uncertain.  The NS5a protein is phosphorylated when expressed in mammalian cells.  It is thought to interact with the ds RNA dependent (interferon inducible) kinase PKR, [swissprot:P19525]. This region corresponds to the 1b domain.
Pfam PF00504: Chlorophyll A-B binding protein (family)
The light-harvesting complex (LHC) consists of chlorophylls A and B and the chlorophyll A-B binding protein. LHC functions as a light receptor that captures and delivers excitation energy to photosystems I and II with which it is closely associated. Under changing light conditions, the reversible phosphorylation of light harvesting chlorophyll a/b binding proteins (LHCII) represents a system for balancing the excitation energy between the two photosystems .

The N terminus of the chlorophyll A-B binding protein extends into the stroma where it is involved with adhesion of granal membranes and photo-regulated by reversible phosphorylation of its threonine residues . Both these processes are believed to mediate the distribution of excitation energy between photosystems I and II.

This family also includes the photosystem II protein PsbS, which plays a role in energy-dependent quenching that increases thermal dissipation of excess absorbed light energy in the photosystem .
Wikipedia: The light-harvesting complex is an array of protein and chlorophyll molecules embedded in the thylakoid membrane of plants and cyanobacteria, which transfer light energy to one chlorophyll a molecule at the reaction center of a photosystem.
Pfam PF01415: Interleukin 7 (domain)
IL-7 is a cytokine that acts as a growth factor for early lymphoid cells of both B- and T-cell lineages. IL-7 and IL-7Ralpha bind the gamma-c receptor forming a complex crucial to several signaling cascades leading to the development and homeostasis of T and B cells.
Wikipedia: Interleukins (ILs) are a group of cytokines that are expressed and secreted by white blood cells (leukocytes) as well as some other body cells. The human genome encodes more than 50 interleukins and related proteins.
Pfam PF21099: DNA_pol_Q helicase like region helical domain (domain)
DNA polymerase theta (Pol Theta, encoded the POLQ gene) is one of ~15 DNA polymerases in the human genome. PolQ is distinct among human DNA polymerases, exhibiting not only a C-terminal DNA polymerase domain but also an N-terminal domain exhibiting similarity and motifs typical of superfamily 2 (SF2) helicases. This entry corresponds to the helical domain.
Pfam PF17167: Glycosyl hydrolase 36 superfamily, catalytic domain (repeat)
This is the catalytic region of the superfamily of enzymes referred to as GH36. UniProtKB:Q76IQ9 is a chitobiose phosphorylase that catalyses the reversible phosphorolysis of chitobiose into alpha-GlcNAc-1-phosphate and GlcNAc with inversion of the anomeric configuration. The full-length enzyme comprises a beta sandwich domain and an (alpha/alpha)(6) barrel domain. The alpha-helical barrel component of the domain, this family, is the catalytic region.
Pfam PF24238: CDGP domain (domain)
This entry represents a family of small lipoproteins found in mycobacteriophage and some mycobacteria. These proteins contain a highly conserved motif CDGPXXPDG that is likely to be functionally important. The domain has been named after part of this motif. The structure of the proteins consists of a four stranded beta meander.
Pfam PF04187: Haem-binding uptake, Tiki superfamily, ChaN (domain)
This is a family of putative bacterial lipoproteins necessary for the uptake of haem-iron.  The structure of UniProtKB:Q0PBW2, PDB:2g5g, comprises a large parallel beta-sheet with flanking alpha-helices and a smaller domain consisting of alpha-helices. Two cofacial haem groups (~3.5 Angstom apart with an inter-iron distance of 4.4 Angstrom) bind in a pocket formed by a dimer of two ChaN monomers.