SII-SWORD/CoKE huggingface dataset:
Pfam PF20710: Domain of unknown function (DUF6824) (domain)
This presumed domain is functionally uncharacterised. This domain family is found in eukaryotes. There are highly conserved motifs: DxxxGR/KG, HxGN and GRFL; and three highly conserved residues: W, K and R at the C-terminal.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF18462: Domain of unknown function (DUF5612) (domain)
This is a domain of unknown function which is mostly found at the C-terminal of ACT domains such as [pfam:PF01842].
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF18051: 26S proteasome non-ATPase regulatory subunit RPN1 C-terminal (domain)
This is the C-terminal domain found in RPN1 proteins (26S proteasome non-ATPase regulatory subunit 2).  The 26S proteasome holocomplex consists of a 28-subunit barrel-shaped core particle (CP) in the center capped at the top and bottom by 19-subunit regulatory particles (RPs). The CP forms the catalytic chamber and the RP is formed from two subcomplexes known as the lid and the base. The lid comprises nine Rpn subunits in yeast (Rpn3/5/6/7/8/9/11/12/15) and the base comprises three Rpn subunits (Rpn1/2/13) and six ATPases (Rpt1-6).
Pfam PF16142: Domain of unknown function (DUF4850) (family)
This family consists of several uncharacterized proteins around 250 residues in length and is mainly found in various Acinetobacter species. The function of this family is unknown.
Pfam PF10438: Cyclo-malto-dextrinase C-terminal domain (domain)
This domain is at the very C-terminus of cyclo-malto-dextrinase proteins and consists of 8 beta strands, is largely globular and appears to help stabilise the acitve sites created by upstream domains, Cyc-maltodext_N [pfam:PF09087], and Alpha-amylase [pfam:PF00128].  Cyclo-malto-dextrinases hydrolyse cyclodextrans to maltose and glucose and catalyse trans-glycosylation of oligosaccharides to the C3-, C4- or C6-hydroxyl groups of various acceptor sugar molecules.
Pfam PF05073: Baculovirus P24 capsid protein (family)
Baculovirus P24 is associated with nucleocapsids of budded and polyhedra-derived virions.
Pfam PF07735: F-box associated (family)
Most of these proteins contain [pfam:PF00646] at the N terminus, suggesting that they are effectors linked with ubiquitination.
Pfam PF05497: Destabilase (family)
Destabilase is an endo-epsilon(gamma-Glu)-Lys isopeptidase, which cleaves  isopeptide bonds formed by transglutaminase (Factor XIIIa) between  glutamine gamma-carboxamide and the epsilon-amino group of lysine.
Pfam PF17141: Domain of unknown function (DUF5114) (family)
This family lies further downstream of DUF5111, [pfam:PF17138], on proteins from Bacteroidetes that also carry a SusE family, [pfam:PF14292].
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF11580: Protein of unknown function (DUF3239) (family)
This bacterial family of proteins may be membrane proteins however this cannot be confirmed. Currently there is no known function.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF06625: Protein of unknown function (DUF1151) (family)
This family consists of several hypothetical eukaryotic proteins of unknown function.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF17321: Vacuole-related protein 17 (family)
Vac17 serves as an adaptor protein recruiting vacuole vesicles to the actin cable tracks by its dual interaction with Vac8 and the Myo2 motor protein. It is directly phosphorylated by Cdk1. Vac17 plays an important role in vacuole inheritance and segregation in cell division.
Pfam PF21626: Tetracyclin repressor, C-terminal domain (domain)
This domain is found at the C-terminal end of Transcriptional regulator from Lactococcus lactis (YgfC, also known as heme- regulated transporter regulator, HrtR) and similar proteins predominantly from firmicutes. YgfC senses and binds a heme molecule to regulate the expression of the heme-efflux system responsible for heme homeostasis in this bacteria. This member of the TetR family of transcriptional regulators shows two helical domains and adopts a dimeric configuration. This entry represents the heme-sensing (heme-binding) domain, which contains the alpha-helices that form the four-helix bundle that constitutes a dimer interface.
Pfam PF08923: Mitogen-activated protein kinase kinase 1 interacting (domain)
Mitogen-activated protein kinase kinase 1 interacting protein is a small subcellular adaptor protein required for MAPK signaling and ERK1/2 activation. The overall topology of this domain has a central five-stranded beta-sheet sandwiched between a two alpha-helix and a one alpha-helix layer.
Pfam PF02141: DENN (AEX-3) domain (family)
DENN (after differentially expressed in neoplastic vs normal cells) is a domain which occurs in several proteins involved in Rab- mediated processes or regulation of MAPK signalling pathways.
Pfam PF23803: Phage tail assembly chaperone (family)
This family represents a phage tail assembly chaperone protein based on structural similarities. This entry represents proteins found in bacteriophages from the Gordonvirus genus.
Pfam PF14258: Domain of unknown function (DUF4350) (domain)
This domain family is found in bacteria, archaea, and is approximately 170 to 200 amino acids in length. This domain is part of the glutaminase superfamily, suggesting it may have an enzymatic function. The domain is founded between two transmembrane helix domains giving it a membrane localisation.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF11663: Toxin with endonuclease activity, of toxin-antitoxin system (domain)
YhaV causes reversible bacteriostasis and is part of a toxin-antitoxin system in Escherichia coli along with PrlF. The toxicity of YhaV is counteracted by PrlF by the formation of a tight complex which binds to the promoter of the prlF-yhaV operon. In vitro, YhaV also has endonuclease activity.
Wikipedia: A toxin-antitoxin system consists of a "toxin" and a corresponding "antitoxin", usually encoded by closely linked genes. The toxin is usually a protein while the antitoxin can be a protein or an RNA. Toxin-antitoxin systems are widely distributed in prokaryotes, and organisms often have them in multiple copies. When these systems are contained on plasmids – transferable genetic elements – they ensure that only the daughter cells that inherit the plasmid survive after cell division. If the plasmid is absent in a daughter cell, the unstable antitoxin is degraded and the stable toxic protein kills the new cell; this is known as 'post-segregational killing' (PSK).
Pfam PF18550: Nitrososphaera output domain 2 (domain)
NitrOD2 (Nitrososphaera output domain 2) is found in thaumarchaea, either in stand-alone form or in combination with the Response_reg [pfam:PF00072] domain (Galperin et al., 2018, Phyletic distribution and lineage-specific domain architectures of archaeal two-component signal transduction systems).
Pfam PF07260: Progressive ankylosis protein (ANKH) (family)
This family consists of several progressive ankylosis protein (ANK or ANKH) sequences. The ANK protein spans the outer cell membrane and shuttles inorganic pyrophosphate (PPi), a major inhibitor of physiologic and pathologic calcification, bone mineralisation and bone resorption. Mutations in ANK are thought to give rise to Craniometaphyseal dysplasia (CMD) which is a rare skeletal disorder characterised by progressive thickening and increased mineral density of craniofacial bones and abnormally developed metaphyses in long bones. This family shows distant homology to the MOP (TCDB) superfamily of transporters.
Pfam PF02364: 1,3-beta-glucan synthase component (family)
This family consists of various 1,3-beta-glucan synthase components including Gls1, Gls2 and Gls3 from yeast. 1,3-beta-glucan synthase [ec:2.4.1.34] also known as callose synthase catalyses the formation of a beta-1,3-glucan polymer that is a major component of the fungal cell wall. The reaction catalysed is:- UDP-glucose + {(1,3)-beta-D-glucosyl}(N)  UDP + {(1,3)-beta-D-glucosyl}(N+1).
Wikipedia: 1,3-Beta-glucan synthase is a glucosyltransferase enzyme involved in the generation of beta-glucan in fungi. It serves as a pharmacological target for antifungal drugs such as caspofungin, anidulafungin, and micafungin, deemed 1,3-Beta-glucan synthase inhibitors. Under the CAZy classification system, fungi and plant members fall in the glycosyltransferase 48 family (GT48). Some members of the glycosyltransferase 2 family, such as the curdlan synthase CrdS, also has a similar activity.
Pfam PF16668: Adhesin from Campylobacter (family)
JLPA is a surface-exposed lipoprotein adhesin that promotes interaction with the host epithelial cells. It is found in the genus Campylobacter, and the structure is an unclosed half beta-barrel fold with a wide hydrophobic concave face; this represents a novel bacterial surface lipoprotein.
Pfam PF03786: D-mannonate dehydratase (UxuA) (family)
UxuA (this family) and UxuB are required for hexuronate degradation.
Pfam PF24408: wHTH-Calcineurin_assc (domain)
This entry represents a wHTH domain found at the C-terminal of proteins containing Calcineurin-CE (covered by [pfam:PF00149]), in antiviral immunity systems containing an ORC/CDC6 like AAA+ ATPase ([pfam:PF24389]).
Pfam PF16034: JAKMIP CC3 domain (coiled_coil)
This domain is found at the C-terminus of proteins belonging to the JAKMIP family (Janus kinase and microtubule-interacting proteins) and is predicted to be a coiled coil. It interacts with the Janus family kinases Tyk2 and Jak1.
Pfam PF24803: Domain of unknown function (DUF7704) (domain)
This domain is found in a group of uncharacterised eukaryotic proteins. It has a detectable similarity to Tumor protein p53-inducible protein 11 (TP53I11) and it is predicted to adopt similar structure.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF23598: Leucine-rich repeat region (repeat)
This entry represents a region containing leucine-rich repeats found in a variety of plant resistance proteins.
Pfam PF11586: Protein of unknown function (DUF3242) (family)
This protein from Thermotoga maritima is a hypothetical ORFan protein, TM1622, whose structure has been determined. The protein is composed of seven beta strands and three alpha helices.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF08112: ATP synthase epsilon subunit (family)
This family consists of epsilon subunits of the ATP  synthase. The ATP synthase complex is composed of an  oligomeric transmembrane sector (CF0), and a catalytic  core (CF1). CF1 is composed of 5 subunits, of which  the epsilon subunit functions as a potent inhibitor of  ATPase activity in both soluble and bound CF1. Only  when the epsilon inhibition is disabled is high ATPase activity detected in ATPase
Pfam PF00778: DIX domain (family)
The DIX domain is present in Dishevelled and axin. This domain is involved in homo- and hetero-oligomerisation. It is involved in the homo- oligomerisation of mouse axin [swissprot:O35625]. The axin DIX domain also interacts with the dishevelled DIX domain. The DIX domain has also been called the DAX domain.
Pfam PF10006: Uncharacterized conserved protein (DUF2249) (domain)
Members of this family of hypothetical bacterial proteins have no known function.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF21729: IRX15/IRX15L/GXM (domain)
This entry represents a group of sugar methyltransferases found in plants and bacteria, including protein IRREGULAR XYLEM IRX15/IRX15L, glucuronoxylan 4-O-methyltransferases 1-3 (GXM1-3) and AMG1/2 (probable methyltransferase At1g27930 and At1g67330, respectively) from Arabidopsis. GXMs and IRX15/15L are all expressed in secondary wall-forming cells and they are all involved in xylan biosynthesis. However, they have different functions. IRX15/IRX15L are required for xylan biosynthesis and/or xylan deposition, although their enzymatic activity is unknown. GXMs catalyse the 4-O-methylation of the glucuronic acid substituent on xylan. This entry also includes AGM1 (also known as probable methyltransferase At1g27930) and AGM2 (At1g67330) which are required for 4-O-methylation of glucuronic acid of arabinogalactan proteins, a different plant cell wall component.
Pfam PF12604: Tail fibre protein gp37 C terminal domain (domain)
This domain family is found in bacteria and viruses, and is typically between 49 and 166 amino acids in length. The family is found in association with [pfam:PF03906]. In T-even phages, gp37 and gp38 are components of the tail fibre that are critical for phage-host interaction.
Pfam PF07498: Rho termination factor, N-terminal domain (domain)
The Rho termination factor disengages newly transcribed RNA from its DNA template at certain, specific transcripts.  It it thought that two copies of Rho bind to RNA and that Rho functions as a hexamer of protomers. This domain is found to the N-terminus of the RNA binding domain ([pfam:PF07497]).
Pfam PF05910: Plant protein of unknown function (DUF868) (family)
This family consists of several hypothetical proteins from Arabidopsis thaliana and Oryza sativa. The function of this family is unknown.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF12902: Ferritin-like (domain)
This is a family of bacterial ferritin-like substances that also includes a C-terminal domain of VioB, polyketide synthase enzymes, that make up one of the key components of the violacein biosynthesis pathway. Violacein is a purple-coloured, broad-spectrum antibacterial pigment.
Pfam PF18857: Large polyvalent protein associated domain 38 (domain)
This is an alpha and beta fold  domain found in polyvalent proteins of phages and prophages.
Pfam PF05050: Methyltransferase FkbM domain (domain)
This domain is characterised by two well-conserved short regions separated by a variable region in both sequence and length. Proteins containing this domain have been characterised as methyltransferases. FkbM, was shown to be required for a specific methylation in the biosynthesis of the immunosuppressant FK506 in Streptomyces strain MA6548. This domain is also found in other methyltransferases such as SdnD from the fungus Sordaria araneosa, involved in the biosynthesis of glycoside antibiotics with tetracyclic diterpene aglycone structure.
Pfam PF22132: TilS-like substrate binding domain (domain)
This entry represents a C-terminal domain (CTD) present in TilS ligases proteins, probably implicated in the recognition of the tRNA accetor stem. TilS ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner.
Pfam PF11090: Bacteriophage T7, probable scaffold protein Gp13 (family)
This family represents Bacteriophage T7 Gp13, which may act as an organiser for the correct association of several proteins in the surrounding of the head-tail connector protein gp8.
Pfam PF22246: NeqB N-terminal domain (domain)
This entry represents the N-terminal domain of the NeqB, a regulatory ATP synthase subunit.
Pfam PF21087: Glycosyl hydrolase family 134 (domain)
This entry represents glycoside hydrolase family 134 which contains beta-1,4-mannanase enzymes. This enzyme has a lysozyme like fold.
Pfam PF14263: Domain of unknown function (DUF4354) (family)
Several members of this family are annotated as being ATP/GTP-binding site motif A (P-loop) proteins, but this could not be confirmed. The one PDB:3NRF structure solved for this family exhibits an immunoglobin-like beta-sandwich fold. Crystal packing suggests that a tetramer is a significant oligomerisation state, and a disulfide bridge is formed between Cys 125 at the C-terminal end of the monomer, and Cys 69.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF04201: Tumour protein D52 family (family)
The hD52 gene was originally identified through its elevated expression level in human breast carcinoma. Cloning of D52 homologues from other species has indicated that D52 may play roles in calcium-mediated signal transduction and cell proliferation. Two human homologues of hD52, hD53 and hD54, have also been identified, demonstrating the existence of a novel gene/protein family. These proteins have an amino terminal coiled-coil that allows members to form homo- and heterodimers with each other.
Pfam PF18034: Bacterial Glycosyl hydrolase family 3 C-terminal domain (domain)
This is the C-terminal domain of the glycoside hydrolase family ([pfam:PF00933])
Wikipedia: In molecular biology, glycoside hydrolase family 3 is a family of glycoside hydrolases. Glycoside hydrolases EC 3.2.1. are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycoside hydrolases, based on sequence similarity, has led to the definition of over 100 different families. This classification is available on the CAZy web site, and also discussed at CAZypedia, an online encyclopedia of carbohydrate active enzymes.
Pfam PF02951: Prokaryotic glutathione synthetase, N-terminal domain (domain)
Prokaryotic glutathione synthetase 6.3.2.3 (glutathione synthase) catalyses the conversion of gamma-L-glutamyl-L-cysteine and glycine to orthophosphate and glutathione in the presence of ATP. This is the second step in glutathione biosynthesis. The enzyme is inhibited by 7,8-dihydrofolate, methotrexate and trimethoprim. This domain is the N terminus of the enzyme.
Wikipedia: Glutathione synthetase (GSS) is the second enzyme in the glutathione (GSH) biosynthesis pathway. It catalyses the condensation of gamma-glutamylcysteine and glycine, to form glutathione. Glutathione synthetase is also a potent antioxidant. It is found in many species including bacteria, yeast, mammals, and plants.
Pfam PF11863: Protein of unknown function (DUF3383) (family)
This family of proteins are functionally uncharacterised. This protein is found in bacteria and viruses. Proteins in this family are typically between 356 to 501 amino acids in length.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF03022: Major royal jelly protein (repeat)
Royal jelly is the food of queen bee larvae, and is responsible for the high reproductive ability of the queen.  Major royal jelly  proteins make up around 90% of larval jelly proteins. This family also the sequence-related yellow protein of drosophila  which controls pigmentation of the adult cuticle and larval mouth  parts.
Pfam PF12791: Anti-sigma factor N-terminus (domain)
The heat shock genes in B. subtilis can be classified into several groups according to their regulation, and the sigma gene, sigI, of Bacillus subtilis belongs to the group IV heat-shock response genes and has many orthologues in the bacterial phylum Firmicutes. Regulation of sigma factor I is carried out by RsgI from the same operon, and this N-terminal cytoplasmic portion of RsgI ('upstream' of the single transmembrane helix) has been shown to interact directly with Sigma-I.
Pfam PF21187: Yeast adenylate cyclase, C-terminal (domain)
Yeast adenylate cyclase (CYAA/CYR1) is required for cAMP production and cAMP-dependent protein kinase signaling. It scaffold protein for Ras2-Ira interaction. This is the C-terminal domain which contains a second Ras binding site (the first resides in the LRR region) which is involved in a GTP-independent weak interaction between Ras and a complex of adenylate cyclase and Srv2 protein. These two Ras binding sites are required for normal Ras2 downregulation.