SII-SWORD/CoKE huggingface dataset:
Pfam PF24554: Domain of unknown function (DUF7603) (domain)
This entry includes uncharacterised fungal sequences. It represents a long alpha-helix found near the C-terminal.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF17737: Ig domain in C19orf38 (HIDE1) (domain)
This entry represents an Ig domain found in the uncharacterized human protein C19orf38, which is found across mammals. Family members have one predicted transmembrane region which is not included in this entry. The C19orf38 protein is also known as HIDE1 after Highly expressed in Immature DEndritic cell transcript 1 protein.
Pfam PF08807: Bacterial domain of unknown function (DUF1798) (domain)
This domain is found in many hypothetical proteins.  The structure of one of the proteins in this family has been solved and it adopts an all alpha helical fold.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF16006: Nucleolar and spindle-associated protein (family)
This family of microtubule-associated proteins has a role in spindle microtubule organisation
Pfam PF04666: N-Acetylglucosaminyltransferase-IV (GnT-IV) conserved region (family)
The complex-type of oligosaccharides are synthesised through elongation by glycosyltransferases after trimming of the precursor oligosaccharides transferred to proteins in the endoplasmic reticulum. N-Acetylglucosaminyltransferases (GnTs) take part in the formation of branches in the biosynthesis of complex-type sugar chains. In vertebrates, six GnTs, designated as GnT-I to -VI, which catalyse the transfer of GlcNAc to the core mannose residues of Asn-linked sugar chains, have been identified. GnT-IV ([ec:2.4.1.145]) catalyses the transfer of GlcNAc from UDP-GlcNAc to the GlcNAc1-2Man1-3 arm of core oligosaccharide [Gn2(22)core oligosaccharide] and forms GlcNAc1-4(GlcNAc1-2)Man1-3 structure on the core oligosaccharide (Gn3(2,4,2)core oligosaccharide).  In some members the conserved region occupies all but the very for N-terminal, where there is a signal sequence on all members. For other members the conserved region does not occupy the entire protein but is still to the N-terminus of the protein.
Pfam PF24285: Family of unknown function (DUF7473) (family)
This family includes a group of proteins from archaea. Members are predicted to adopt an alpha-helical structure.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF17398: Nodulation protein NolB (family)
This domain family of unknown function is found in Rhizobiales. Family members are involved in Nodulation (nodule development in plants).
Pfam PF20047: Domain of unknown function (DUF6449) (domain)
This presumed domain is functionally uncharacterised found in ABC  transporter permeases. This domain family is found in bacteria and is approximately 300 amino acids in length.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF08784: Replication protein A C terminal (domain)
This domain corresponds to the C terminal of the single stranded DNA binding protein RPA (replication protein A).  RPA is involved in many DNA metabolic pathways including DNA replication, DNA repair, recombination, cell cycle and DNA damage checkpoints.
Wikipedia: Replication protein A (RPA) is the major protein that binds to single-stranded DNA (ssDNA) in eukaryotic cells. In vitro, RPA shows a much higher affinity for ssDNA than RNA or double-stranded DNA. RPA is required in replication, recombination and repair processes such as nucleotide excision repair and homologous recombination. It also plays roles in responding to damaged DNA.
Pfam PF20717: Family of unknown function (DUF6829) (family)
This family is functionally uncharacterised. This domain family is found in eukaryotes, and is around 420 amino acids in length. Structurally, this family is made of alpha helices.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF11795: Uncharacterized protein conserved in bacteria N-term (DUF3322) (domain)
This domain, found in various hypothetical bacterial proteins, has no known function. The family represents just the N-terminus.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF08510: PIG-P (family)
PIG-P (phosphatidylinositol N-acetylglucosaminyltransferase subunit P) is an enzyme involved in GPI anchor biosynthesis.
Pfam PF06390: Neuroendocrine-specific golgi protein P55 (NESP55) (family)
This family consists of several mammalian neuroendocrine-specific golgi protein P55 (NESP55) sequences. NESP55 is a novel member of the chromogranin family and is a soluble, acidic, heat-stable secretory protein that is expressed exclusively in endocrine and nervous tissues, although less widely than chromogranins.
Pfam PF04029: 2-phosphosulpholactate phosphatase (family)
Thought to catalyse 2-phosphosulpholactate = sulpholactate + phosphate. Probable magnesium cofactor.  Involved in the second step of coenzyme M biosynthesis.  Inhibited by vanadate in Methanococcus jannaschii.  Also known as the ComB family.
Pfam PF21098: MTMR6-9, GRAM domain (domain)
This entry represents a PH-like domain found in a variety of myotubularin proteins, including MTMR6-9. MTMR6-8 are lipid phosphatases that specifically dephosphorylates the D-3 position of phosphatidylinositol 3-phosphate (PtdIns3P) and inositol 1,3-bisphosphate (Ins(1,3)P2). MTMR8, in complex with MTMR9 negatively regulates autophagy. Moreover, MTMR6 in complex with MTMR9 negatively regulates DNA damage-induced apoptosis. MTMR9 acts as an adapter for myotubularin-related phosphatases, positively regulating the catalytic activity of MTMR6 and MTMR7. MTMR9 lacks the conserved active site cysteine residue at position 333 in the dsPTPase catalytic loop, suggesting that it has no phosphatase activity.
Pfam PF11900: Domain of unknown function (DUF3420) (repeat)
This presumed domain is functionally uncharacterised. This domain is found in eukaryotes. This domain is about 50 amino acids in length. This domain is found associated with [pfam:PF00023].
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF14740: Domain of unknown function (DUF4471) (domain)
This family is conserved from fungi to Metazoa and includes plants.  The function is not known, but several members have zinc-finger domain, zf-MYND, [pfam:PF01753], at their very C-terminus. Others are also associated with DUF1279, [pfam:PF06916]. This domain is more C-terminal in many members to DUF4470, [pfam:PF14737].
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF08067: ROKNT (NUC014) domain (domain)
This presumed domain is found at the N-terminus of RNP K-like proteins that also contains KH domains [pfam:PF00013].
Pfam PF07959: Fucose pyrophosphorylase domain (domain)
This entry represents the fucose pyrophosphorylase domain found at the N-terminal of the bifunctional L-Fucokinase/GDP-Fucose Pyrophosphorylase (FKP) enzymes such as FKGP from Arabidopsis and L-fucose kinase from animals. In fucose-1-phosphate guanylyltransferase from human, this is the main domain of the protein, which catalyses the formation of GDP-L-fucose from GTP and L-fucose-1-phosphate and functions as a salvage pathway to reutilise L-fucose arising from the turnover of glycoproteins and glycolipids. In the salvage pathway of GDP-L-fucose, free cytosolic fucose is phosphorylated by fucokinase to form L-fucose-L-phosphate, which is then further converted to GDP-L-fucose in the reaction catalysed by GDP-L-fucose pyrophosphorylase. The structure of this domain has been determined; it consists of a typical Rossmann fold and a left-handed beta-helix fold inserted on it. This domain contains a loop region that is critical to the GDP-fucose pyrophosphorylase activity of FKP and may be the putative GTP binding site during catalysis (which contains the HXGGXSXRXP(X)5GK motif).
Pfam PF07698: 7TM receptor with intracellular HD hydrolase (domain)
These bacterial 7TM receptor proteins have an intracellular [pfam:PF01966].  This entry corresponds to the 7 helix transmembrane domain.  These proteins also contain an N-terminal extracellular domain.
Pfam PF00347: Ribosomal protein L6 (domain)
This entry represents the Î±-Î² domain found duplicated in ribosomal uL6 proteins. This domain consists of two Î²-sheets and one Î±-helix packed around single core .
Large ribosomal subunit protein uL6 was previously known as L6. In Escherichia coli, it is located in the aminoacyl-tRNA binding site of the peptidyltransferase centre, and is known to bind directly to 23S rRNA. It belongs to a family of ribosomal proteins, including L6 from bacteria, cyanelles (structures that perform similar functions to chloroplasts, but have structural and biochemical characteristics of Cyanobacteria) and mitochondria; and L9 from mammals, Drosophila, plants and yeast. L6 contains two domains with almost identical folds, suggesting that is was derived by the duplication of an ancient RNA-binding protein gene. Analysis reveals several sites on the protein surface where interactions with other ribosome components may occur, the N terminus being involved in protein-protein interactions and the C terminus containing possible RNA-binding sites .
Ribosomes are the particles that catalyse mRNA-directed protein synthesis in all organisms. The codons of the mRNA are exposed on the ribosome to allow tRNA binding. This leads to the incorporation of amino acids into the growing polypeptide chain in accordance with the genetic information. Incoming amino acid monomers enter the ribosomal A site in the form of aminoacyl-tRNAs complexed with elongation factor Tu (EF-Tu) and GTP. The growing polypeptide chain, situated in the P site as peptidyl-tRNA, is then transferred to aminoacyl-tRNA and the new peptidyl-tRNA, extended by one residue, is translocated to the P site with the aid the elongation factor G (EF-G) and GTP as the deacylated tRNA is released from the ribosome through one or more exit sites . About 2/3 of the mass of the ribosome consists of RNA and 1/3 of protein. The proteins are named in accordance with the subunit of the ribosome which they belong to the small (S1 to S31) and the large (L1 to L44). Usually they decorate the rRNA cores of the subunits.

Many ribosomal proteins, particularly those of the large subunit, are composed of a globular, surfaced-exposed domain with long finger-like projections that extend into the rRNA core to stabilise its structure. Most of the proteins interact with multiple RNA elements, often from different domains. In the large subunit, about 1/3 of the 23S rRNA nucleotides are at least in van der Waal's contact with protein, and L22 interacts with all six domains of the 23S rRNA. Proteins S4 and S7, which initiate assembly of the 16S rRNA, are located at junctions of five and four RNA helices, respectively. In this way proteins serve to organise and stabilise the rRNA tertiary structure. While the crucial activities of decoding and peptide transfer are RNA based, proteins play an active role in functions that may have evolved to streamline the process of protein synthesis. In addition to their function in the ribosome, many ribosomal proteins have some function 'outside' the ribosome .
Pfam PF05695: Ycf2 family (family)
This entry, previously known as DUF825, represents Ycf2 protein from Arabidopsis thaliana and related plant proteins. Ycf2 is a component of the Ycf2-FtsHi complex which has been identified as chloroplast import motor. The Ycf2-FtsHi complex is composed of six distinct components. This heterohexameric assembly is organized in a counterclockwise order with components arranged as Ycf2, FtsHi5, FtsHi1, FtsHi2, FtsHi4, and FtsH12. A collaborative interplay between the Ycf2-FtsHi complex and the TIC (translocon at the inner chloroplast membrane) complex, contributes to the efficient translocation of preproteins into the chloroplasts.
Pfam PF15995: Domain of unknown function (DUF4771) (family)
This domain family is found in eukaryotes, and is approximately 160 amino acids in length. There is a conserved RYGK sequence motif.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF23355: IFT52 GIFT domain (domain)
This domain is found in various eukaryotic and prokaryotic intra-flagellar transport proteins involved in gliding motility, as well as in several hypothetical proteins. Intraflagellar transport protein 52 homolog from human is included in this entry, which is essential for anterograde complex integrity and for the biosynthesis and maintenance of cilia. This domain has been described as the GIFT domain in IFT52 whose function is not yet clear.
Pfam PF23048: UBE2O, N-terminal SH3-A domain (domain)
This domain is found in the human E3-independent E2 ubiquitin-conjugating enzyme UBE2O and related proteins. UBE2O is involved in the monoubiquitination of diverse targets to mediate important processes such as targeting proteins for quality control, regulation of nuclear trafficking of chromatin-associated proteins and clearing ribosomes during erythropoiesis. UBE2O is a multidomain protein composed of several SH3-like domains, UBC domain and a CR3 helix. The domain represented by this entry folds into an open beta-barrel with a typical SH3-like topology. This domain contains a large unstructured insertion that is rich with glycine residues.
Pfam PF23429: Family of unknown function (DUF7116) (family)
This family represents a group of proteins from halobacteria. It has several conserved motifs LGY, AERK/EWK/R, RCFV and YxWA. Members are predicted to show an alpha-beta configuration.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF12240: Angiomotin C terminal (coiled_coil)
This domain family is found in eukaryotes, and is typically between 197 and 211 amino acids in length. This family is the C terminal region of angiomotin. Angiomotin regulates the action of angiogenesis inhibitor angiostatin. The C terminal region of angiomotin appears to be involved in directing the protein chemotactically.
Pfam PF06776: Invasion associated locus B (IalB) protein (family)
This family consists of several invasion associated locus B (IalB) proteins and related sequences. IalB is known to be a major virulence factor in Bartonella bacilliformis where it was shown to have a direct role in human erythrocyte parasitism. IalB is upregulated in response to environmental cues signaling vector-to-host transmission. Such environmental cues would include, but not be limited to, temperature, pH, oxidative stress, and haemin limitation. It is also thought that IalB would aide B. bacilliformis survival under stress-inducing environmental conditions. The role of this protein in other bacterial species is unknown.
Pfam PF22669: Endonuclease/Exonuclease/phosphatase family 2 (domain)
This large family of proteins includes a number of nucleases and phosphatases such as DNAase I, Exonuclease III and Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase.
Pfam PF11789: Zinc-finger of the MIZ type in Nse subunit (domain)
Nse1 and Nse2 are novel non-SMC subunits of the fission yeast Smc5-6 DNA repair complex. This family is the zinc-finger domain similar to the MIZ type of zinc-finger.
Pfam PF17522: Family of unknown function (DUF5446) (family)
This is a family of unknown function found in Bacillales.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF24847: Domain of unknown function (DUF7722) (domain)
This domain is found in uncharacterised plant proteins. It is predicted to contain helix-extended loop-helix (HeH) structure and has similarity to domains containing this motif.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF23198: PDE8A-like, N-terminal domain (domain)
This domain is found at the N-terminal of human High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A (PDE8A), which hydrolyses the the second messenger cAMP, a key regulator of many important physiological processes. This domain is predicted to adopt a Rossmann fold similar to CheY-type chemotaxis response regulators.
Pfam PF12818: dsDNA viral tegument protein (family)
This is a family of tegument proteins from double-stranded DNA herpesvirus and related viral species.
Pfam PF03335: Phage tail fibre repeat (repeat)
This entry represents repeat 1 of Tail fibre protein from Bacteriophage lambda (Stf or Gp27) and similar proteins from the tailed bacteriophages Caudovirales, such as Long-tail fibre protein gp37 from Bacteriophage T4 (Gp37), and prophages mainly found in Gammaproteobacteria such as Prophage side tail fibre protein homologue StfQ from Escherichia coli (strain K12).

The strain of the Bacteriophage lambda used in most laboratories in the early 1990's carried some mutations respect to the wild type. Stf is the gene product of one of these mutations, which allow the virus to bind to an additional outer membrane receptor and accelerate the rate of adsorption onto the host cell surface but a higher failed infection frequency .
Pfam PF06250: YhcG PDDEXK nuclease domain (domain)
This domain can be found in uncharacterised proteins in viruses, archaea and bacteria, most notably it is found in YhcG proteins found in E.coli. This entry represents the C-terminal PDDEXK domain belonging to the PD-(D/E)XK superfamily of nucleases involved in DNA recombination and repair. Profile HMM analysis identified a relationship between this C-terminal domain of YhcG and [pfam:PF01939] , a family of NucS endonucleases. YHcG was identified in association with DNA processing enzymes, including the restriction complexes HsdMRS and McrABC, the integrases IntF and IntS, and the recombinase PinE.
Pfam PF06637: PV-1 protein (PLVAP) (family)
This family consists of several PV-1 (PLVAP) proteins which seem to be specific to mammals. PV-1 is a novel protein component of the endothelial fenestral and stomatal diaphragms. The function of this family is unknown.
Pfam PF06353: Protein of unknown function (DUF1062) (family)
This family consists of several hypothetical bacterial proteins of unknown function.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF24270: Cmi2, C-terminal (domain)
This domain is found at the C-terminal end of the predicted ArsR family transcription regulator Cmi2.