SII-SWORD/CoKE huggingface dataset:
Pfam PF04282: Family of unknown function (DUF438) (family)
This is a a group of uncharacterised proteins.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF12175: White spot syndrome virus structural envelope protein VP (domain)
This family of proteins is found in viruses. Proteins in this family are approximately 210 amino acids in length. There is a conserved NNT sequence motif.  These proteins are structural envelope proteins in viruses. This is the beta barrel C terminal domain. There is a protruding N terminal domain which completes the proteins. Three of four envelope proteins in white spot syndrome virus share sequence homology with each other and are present in this family - VP24, VP26 and VP28. VP19 is the other major envelope protein but shares no sequence homology with the other proteins. These proteins are essential for entry into cells of the crustacean host.
Pfam PF19114: EsV-1-7 cysteine-rich motif (repeat)
The EsV-1-7 repeat is a cysteine-rich motif of unknown function. The  motif was originally identified in the Ectocarpus "immediate upright" protein, which has an EsV-1-7 domain that contains five EsV-1-7  repeats. The name is derived from the Ectocarpus virus EsV-1  protein EsV-1-7, which possesses six EsV-1-7 repeats. Ectocarpus has  a large family of EsV-1-7 domain proteins with between one and 19  copies of the motif (C-X4-C-X16-C-X2-H-X12). In addition to brown  algae, EsV-1-7 domain proteins have been found in eustigmatophytes,  oomycetes, cryptophytes, two families of green algae (Coccomyxaceae  and Selenastraceae) and also in viral genomes, such as Emiliania huxleyi virus PS401 and Pithovirus sibericum. Based on this unusual distribution, it has been proposed that EsV-1-7 domain genes have been exchanged between lineages by horizontal gene transfer during  evolution.
Pfam PF03161: LAGLIDADG DNA endonuclease family (family)
This is a family of site-specific DNA endonucleases encoded by DNA mobile elements. Similar to [pfam:PF00961], the members of this family are also LAGLIDADG endonucleases.
Wikipedia: The homing endonucleases are a collection of endonucleases encoded either as freestanding genes within introns, as fusions with host proteins, or as self-splicing inteins. They catalyze the hydrolysis of genomic DNA within the cells that synthesize them, but do so at very few, or even singular, locations. Repair of the hydrolyzed DNA by the host cell frequently results in the gene encoding the homing endonuclease having been copied into the cleavage site, hence the term 'homing' to describe the movement of these genes. Homing endonucleases can thereby transmit their genes horizontally within a host population, increasing their allele frequency at greater than Mendelian rates.
Pfam PF04256: Protein of unknown function (DUF434) (family)
The function of DUF434 is not known.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF21968: TcdA1, receptor binding domain (domain)
This domain is found in TcdA1 from Photorhabdus luminescens and similar sequences from proteobacteria. TcdA1 is one of the three subunits of the Tc toxins. TcdA1 acts as an injecting device responsible for translocating the actual toxic component into host cells. TcA has four receptor-binding domains. This domain is one of 4 receptor binding domains found in TcA. All four domains have an immunoglobulin (Ig)-like beta-sandwich fold of two sheets with antiparallel beta-strands.
Pfam PF13075: Protein of unknown function (DUF3939) (family)
This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 150 amino acids in length.
Pfam PF12359: Protein of unknown function (DUF3645) (family)
This domain family is found in eukaryotes, and is approximately 40 amino acids in length. There is a conserved HPD sequence motif.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF14232: Domain of unknown function (DUF4334) (family)
This domain family is found in bacteria and eukaryotes, and is approximately 60 amino acids in length. This domain is frequently found at the C-terminus of [pfam:PF14231].
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF24576: Ionotropic receptor 75a N-terminal (domain)
This entry represents the N-terminal domain of the Ionotropic receptor 75a (IR75A) from Drosophila melanogaster and related sequences from arthropods. IR75A is an odorant receptor for acetic and propionic acid. It functions as part of an olfactory receptor complex including the ionotropic receptor coreceptor Ir8a. This domain may adopt a periplasmic-binding protein domain fold.
Pfam PF22965: Integrator complex subunit 7, C-terminal domain (domain)
This entry represents a C-terminal domain found in the Integrator complex subunit 7 (INTS7). INTS7 is a component of the integrator complex, a complex that is recruited to the U1 and U2 snRNA genes and mediates the snRNAs' 3' end processing. The integrator complex interacts with the C-terminal tail of the largest subunit of RNA-polymerase II to promote 3'-snRNA processing.
Pfam PF15438: Antigenic membrane protein of phytoplasma (family)
Phyto-Amp is a family of phytopathogenic wall-less bacterial antigenic membrane proteins. The bacteria are limited to the phloem and pose a major threat to agriculture worldwide. They are transmitted in a persistent, propagative manner by phloem-sucking Hemipteran insects. Phytoplasma membrane proteins are in direct contact with hosts and are assumed to be involved in determining vector specificity. Phyto-Amp is thought to be one family of proteins that mediates such specificity. The proteins appear to be encoded by circular extrachromosomal elements, at least one of which is a plasmid.
Pfam PF02518: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (domain)
This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.
Wikipedia: The GHKL domain is an evolutionary conserved protein domain. It is an ATPase domain found in several ATP-binding proteins such as histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins.
Pfam PF14837: Integrator complex subunit 5 N-terminus (family)
This family of proteins represents the N-terminus of subunit 5 of the integrator complex involved in snRNA transcription and processing.
Pfam PF19662: Family of unknown function (DUF6165) (family)
This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria, eukaryotes and viruses. Proteins in this family are typically between 129 and 147 amino acids in length.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF13218: Protein of unknown function (DUF4026) N-terminal (domain)
This domain is found N-terminal in functionally uncharacterised bacterial proteins. This domain is found in association with [pfam:PF22789] and [pfam:PF10077], that are located C-terminal.
Pfam PF15129: ALK and LTK ligand 1/2 (family)
This entry includes ALK and LTK ligand 1 and 2 (ALKL1/2, also known as FAM150A and B, respectively) from vertebrates. ALKL1/2 are activating ligands for the receptor anaplastic lymphoma kinase (ALK) and the receptor leukocyte tyrosine kinase (LTK). However, ALKL1 does not act as a potent physiological ligand for ALK, in contrast to ALKL2. Monomeric ALKAL1 binds to LTK, leading to LTK homodimerisation and activation. It is not yet clear  if ALKL2 activates ALK as a homodimer or a monomer.
Pfam PF12752: SUZ domain (domain)
The SUZ domain is a conserved RNA-binding domain found in eukaryotes and enriched in positively charged amino acids. It was first characterised in the C.elegans protein Szy-20 where it has been shown to bind RNA and allow their localisation to the centrosome. Warning- the domain has a compositionally biased character.
Pfam PF00666: Cathelicidin (domain)
A novel protein family, showing a conserved proregion and a variable carboxyl-terminal antimicrobial domain. This region shows similarity to cystatins.
Wikipedia: Cathelicidin antimicrobial peptide (CAMP) is an antimicrobial peptide
encoded in the human by the CAMP gene. The active form is LL-37. In humans, CAMP encodes the peptide precursor CAP-18, which is processed by proteinase 3-mediated extracellular cleavage into the active form LL-37.
Pfam PF15753: Biogenesis of lysosome-related organelles complex 1 subunit 3 (family)
This family of proteins are components of the biogenesis of lysosome-related organelles complex-1 (BLOC-1).
Pfam PF10317: Serpentine type 7TM GPCR chemoreceptor Srd (family)
Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srd is part of the larger Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.
Pfam PF15171: Neuropeptide secretory protein family, NPQ, spexin (family)
Spexin, alternatively named NPQ, is a peptide hormone and is derived from a pro-hormone. This family of proteins has a role in inducing stomach wall contraction and is expressed in the submucosal layer of the mouse oesophagus and stomach. Spexin, like most peptide hormones, is a ligand for G-protein coupled receptors. Spexin is also thought to have a role in controlling arterial blood pressure as well as salt and water balance.
Pfam PF04551: GcpE protein (family)
In a variety of organisms, including plants and several eubacteria, isoprenoids are synthesised by the mevalonate-independent 2-C-methyl-D-erythritol 4-phosphate (MEP) pathway. Although different enzymes of this pathway have been described, the terminal biosynthetic steps of the MEP pathway have not been fully elucidated. GcpE gene of Escherichia coli is involved in this pathway.
Pfam PF06771: Viral Desmoplakin N-terminus (family)
This family represents the N-terminus of viral desmoplakin. Desmoplakin is a component of mature desmosomes, which are the main adhesive junctions in epithelia and cardiac muscle. Desmoplakin is also essential for the maturation of adherens junctions. Note that many family members are hypothetical.
Pfam PF06083: Interleukin-17 (family)
IL-17 is a potent proinflammatory cytokine produced by activated memory T cells. The IL-17 family is thought to represent a distinct signaling system that  appears to have been highly conserved across vertebrate evolution.
Wikipedia: Interleukins (ILs) are a group of cytokines that are expressed and secreted by white blood cells (leukocytes) as well as some other body cells. The human genome encodes more than 50 interleukins and related proteins.
Pfam PF04319: NifZ domain (domain)
This short protein is found in the nif (nitrogen fixation) operon.  Its function is unknown but is probably involved in nitrogen fixation or regulating some component of this process. This 75 residue region is presumed to be a domain.  It is found in isolation in some members and in the amino terminal half of the longer NifZ proteins.
Pfam PF12135: Plasmodium repeat family (repeat)
This repeat is found in plasmodia. This entry contains two copies of the repeat.  The function of these proteins is unknown.
Pfam PF10661: WXG100 protein secretion system (Wss), protein EssA (family)
The WXG100 protein secretion system (Wss) is responsible for the secretion of WXG100 proteins ([pfam:PF06013]) such as ESAT-6 and CFP-10 in Mycobacterium tuberculosis or EsxA and EsxB in Staphylococcus aureus. In S. aureus, the Wss seems to be encoded by a locus of eight CDS, called ess (eSAT-6 secretion system). This locus encodes, amongst several other proteins, EssA, a protein predicted to possess one transmembrane domain. Due to its predicted membrane location and its absolute requirement for WXG100 protein secretion, it has been speculated that EssA could form a secretion apparatus in conjunction with the polytopic membrane protein EsaA, YukC ([pfam:PF10140]) and YukAB, which is a membrane-bound ATPase containing Ftsk/SpoIIIE domains ([pfam:PF01580]) called EssC in S. aureus and Snm1/Snm2 in Mycobacterium tuberculosis. Proteins homologous to EssA, YukC, EsaA and YukD seem absent from mycobacteria.
Pfam PF13268: Protein of unknown function (DUF4059) (family)
This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 70 amino acids in length. There is a conserved DKT sequence motif.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF09804: DENN domain-containing protein 11 (family)
DENN domain-containing protein 11 (also known as LCHN) is thought  to play a role in neuritogenesis, as well as in neuronal recovery  and/or restructuring in the hippocampus following transient cerebral  ischemia.
Pfam PF07956: Protein of Unknown function (DUF1690) (family)
Family of uncharacterised fungal proteins.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF17654: Selenocysteine tRNA 1 associated proteins (family)
This entry represents the C-terminal region of Selenocysteine tRNA 1 associated proteins (Trnau1ap also known as Secp43). Family members found in Eukaryotes have been shown to serve an essential role in the synthesis of selenoproteins, which have critical functions in numerous biological processes. Selenium deficiency results in a variety of diseases, including cardiac disease. Trnau1ap proteins harbor RNA recognition motifs (RRM) [pfam:PF00076] and Tyr-rich region found in the C-terminal. The Tyr-rich region (amino acids 185-225) is conserved among several mammals, including human, chimp, dog, cattle, mouse and rat. Furthermore, constitutive deletion of exons corresponding to the Tyr-rich region in mouse resulted in embryonic lethality.
Pfam PF13821: Domain of unknown function (DUF4187) (domain)
This family is found at the very C-terminus of proteins that carry a G-patch domain, [pfam:PF01585].  The domain is short and cysteine-rich.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF06041: Bacterial protein of unknown function (DUF924) (repeat)
This family consists of several hypothetical bacterial proteins of unknown function. Structurally, this family resembles TPR-like repeats.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF17413: Outer membrane lipoprotein virB7 (family)
The type IV secretion systems (T4SSs) are ancestrally related to bacterial conjugation machines and are able to translocate proteins and/or protein-DNA complexes to the extracellular milieu or the host interior, in many cases contributing to the ability of the bacterial pathogen to colonize the host and evade its immune system. In the pathogenic plant pathogen Agrobacterium tumefaciens T4SS allows the bacterium to transfer a segment of its tumor inducing (Ti-) plasmid DNA into plant cells causing crown gall tumor disease. Proteins in the virB and virD operons catalyze processing of the T-DNA and its transfer to plants. The VirB proteins assemble a secretion apparatus spanning both bacterial membranes to allow transfer of DNA and protein substrates into plant cells. VirB7 and VirB8, along with VirB6, VirB9 and VirB10, are the core components of the Agrobacterium DNA translocation apparatus. Structural studies with the Escherichia coli plasmid pKM101 VirB homologues showed that three proteins, TraN (VirB7 homologue), TraO (VirB9) and TraF (VirB10), form a hetero-tetradecameric structure with 14-fold symmetry forming an outer membrane channel through which the substrates pass. VirB7 stabilizes VirB9 and in its absence bacteria do not accumulate VirB9 preventing assembly of the secretion machine. Members of the VirB7 family are typically 45-65 residues long, becoming 15-20 residues shorter after removal of the N-terminal signal sequence and covalent attachment to lipid molecules.
Pfam PF24091: Family of unknown function (DUF7376) (family)
This entry represents a family of uncharacterised phage proteins. Structure prediction suggests these protein may form a homodimer. The dimer contains a large circular channel that is positively charged suggesting a possible DNA-binding function.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF15966: F-box (domain)
First identified in cyclin-F as a protein-protein interaction motif, the F-box is a conserved domain that is present in numerous proteins with a bipartite structure . Through the F-box, these proteins are linked to the Skp1 protein and the core of SCFs (Skp1-cullin-F-box protein ligase) complexes. SCFs complexes constitute a new class of E3 ligases . They function in combination with the E2 enzyme Cdc34 to ubiquitinate G1 cyclins, Cdk inhibitors and many other proteins, to mark them for degradation. The binding of the specific substrates by SCFs complexes is mediated by divergent protein-protein interaction motifs present in F-box proteins, like WD40 repeats, leucine rich repeats  or ANK repeats.
Wikipedia: F-box proteins are proteins containing at least one F-box domain. The first identified F-box protein is one of three components of the SCF complex, which mediates ubiquitination of proteins targeted for degradation by the 26S proteasome.
Pfam PF14009: PADRE domain (domain)
This entry represents the Pathogen and abiotic stress response, cadmium tolerance, disordered region-containing (PADRE) domain, which is specifically found in plants. PADRE typically occurs in small single-domain proteins with a bipartite architecture. PADRE contains conserved sequence motifs at the N-terminal, and its C-terminal includes an intrinsically disordered region with multiple phosphorylation sites. This domain is associated with plant defense upon diverse stress stimulus and has a role in disease resistance to fungi.
Pfam PF24504: Rod, N-terminal (repeat)
This entry represents the beta-propeller domain found at the N-terminal of Rod (SwissProt:Q9V9W7) protein from Drosophila and relates sequences from arthropods, which is the orthologue of human KNTC1. Rod is the major subunit of the Rod-Zw10-Zwilch (RZZ) complex. RZZ is an essential component of the outer kinetochore during mitosis and helps monitor and correct kinetochore-microtubule attachments during pro-metaphase, thus, regulating mitotic progression.
Pfam PF07627: Protein of unknown function (DUF1588) (family)
A region of similarity shared by several Rhodopirellula baltica cytochrome-like proteins that are predicted to be secreted. These proteins also match [pfam:PF07626] and [pfam:PF07624].
Pfam PF00274: Fructose-bisphosphate aldolase class-I (domain)
Fructose-bisphosphate aldolase (4.1.2.13)  is a glycolytic enzyme that catalyses the reversible aldol cleavage or condensation of fructose-1,6-bisphosphate into dihydroxyacetone-phosphate and glyceraldehyde 3-phosphate. There are two classes of fructose-bisphosphate aldolases with different catalytic mechanisms: class I enzymes  do not require a metal ion, and are characterised by the formation of a Schiff base intermediate between a highly conserved active site lysine and a substrate carbonyl group, while the class II enzymes require an active-site divalent metal ion. This entry represents the class I enzymes.

In vertebrates, three forms of this enzyme are found: aldolase A is expressed in muscle, aldolase B in liver, kidney, stomach and intestine, and aldolase C in brain, heart and ovary. The different isozymes have different catalytic functions: aldolases A and C are mainly involved in glycolysis, while aldolase B is involved in both glycolysis and gluconeogenesis. Defects in aldolase A cause Glycogen storage disease 12 (GSD12) , while defects in aldolase B result in hereditary fructose intolerance .
Wikipedia: Fructose-bisphosphate aldolase, often just aldolase, is an enzyme catalyzing a reversible reaction that splits the aldol, fructose 1,6-bisphosphate, into the triose phosphates dihydroxyacetone phosphate (DHAP) and glyceraldehyde 3-phosphate (G3P). Aldolase can also produce DHAP from other (3S,4R)-ketose 1-phosphates such as fructose 1-phosphate and sedoheptulose 1,7-bisphosphate. Gluconeogenesis and the Calvin cycle, which are anabolic pathways, use the reverse reaction. Glycolysis, a catabolic pathway, uses the forward reaction. Aldolase is divided into two classes by mechanism.