SII-SWORD/CoKE huggingface dataset:
Pfam PF09945: Predicted membrane protein (DUF2177) (family)
This domain, found in various hypothetical bacterial proteins, has no known function.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF10358: N-terminal C2 in EEIG1 and EHBP1 proteins (domain)
This version of the C2 domain was initally identified in the vertebrate estrogen early-induced gene 1 (EEIG1), and its Drosophila ortholog required for uptake of dsRNA via  the endocytotic machinery to induce RNAi silencing.  It is also in C.elegans ortholog Sym-3  (SYnthetic lethal with Mec-3) and the mammalian protein EHBP1  (EH domain Binding Protein-1) that regulates endocytotic recycling  and two plant proteins, RPG that regulates Rhizobium-directed polar  growth and PMI1 (Plastid Movement Impaired 1) that is essential for intracellular movement of chloroplasts in response to blue light.
Pfam PF18150: Domain of unknown function (DUF5600) (domain)
This domain can be found in EH-domain-containing ATPase 2 (EHD2) present in Mus musculus. The domain is helical in nature and has extensive contacts with the G-domain.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF16947: N-terminal region of 4Fe-4S ferredoxin iron-sulfur binding (family)
Ferredoxin_N is a short domain that is often found at the N-terminus of 4Fe-4S ferredoxin iron-sulfur binding domain proteins from Archaea and a few bacteria.
Pfam PF15635: GHH signature containing HNH/Endo VII superfamily nuclease toxin 2 (family)
A predicted toxin of the HNH/Endonuclease VII fold present in bacterial polymorphic toxin systems with a characteristic s[AGP]HH signature motif. In bacterial polymorphic toxin systems, the toxin is exported by the type 2 or type secretion system.
Pfam PF21248: Protein adenylyltransferase SoFic-like, C-terminal domain (domain)
This domain is found at the C-terminal end of Protein adenylyltransferase SoFic from Shewanella oneidensis and similar bacterial sequences. SoFic mediates the addition of adenosine 5'-monophosphate (AMP) to specific residues of target proteins. This is a winged-helix DNA-binding domain often found associated with [pfam:PF02661].
Pfam PF24137: Diels-Alderase N-terminal domain (domain)
This entry represents the N-terminal domain found in a number of fungal Diels-Alderases, including cghA, eqx3, poxQ and phmD. These proteins catalyse different pericyclic [4+2] cycloaddition reactions that synthesise potential pharmaceuticals and mycotoxins. In CghA, this domain binds substrate alongside a similarly folded C-terminal domain and achieves catalysis by restricting the movement of the straight-chain substrate into a conformation that facilitates a stereoselective cycloaddition reaction.
Pfam PF22633: NedA-like, galactose-binding domain (domain)
This galactose-binding domain is found in Sialidase from Micromonospora viridifaciens (NedA), which releases sialic acids for use as carbon and energy sources. This domain shows a jelly-roll topology.
Pfam PF24052: Phage lipoprotein family (family)
This entry represents a small family of uncharacterised phage proteins that have an N-terminal lipoprotein attachment motif. This suggests that these proteins are expressed on the host bacterial cell membrane.
Pfam PF05504: Spore germination B3/ GerAC like, C-terminal (family)
The GerAC protein of the Bacillus subtilis spore is required for the  germination response to L-alanine. Members of this family are thought to be located in the inner spore membrane. Although the function of this family is unclear, they are likely to encode the components of the  germination apparatus that respond directly to this germinant,  mediating the spore's response.
Pfam PF24136: Domain of unknown function (DUF7403) (domain)
This entry represents a domain of unknown function found in some PRiA4b ORF-3-like proteins from bacteria, such as SwissProt:A0A1I7K0M5. This domain may adopt an all-helical fold and is generally found alongside the PriA4_ORF3 ([pfam:PF07929]) domain.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF21806: Family of unknown function (DUF6879) (domain)
This family of proteins are uncharacterised. However, they fold into a compact domain that is structurally related to the Phospholipase D protein family ([pfam:PF13091]). This suggests they may have an enzymatic activity.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF00050: Kazal-type serine protease inhibitor domain (domain)
Usually indicative of serine protease inhibitors. However, kazal-like domains are also seen in the extracellular part of agrins, which are not known to be protease inhibitors. Kazal domains often occur in tandem arrays. Small alpha+beta fold containing three disulphides. Alignment also includes a single domain from transporters in the OATP/PGT family [swissprot:P46721].
Wikipedia: The Kazal domain  is an evolutionary conserved protein domain usually indicative of serine protease inhibitors. However, kazal-like domains are also seen in the extracellular part of agrins, which are not known to be protease inhibitors.
Pfam PF12951: Passenger-associated-transport-repeat (repeat)
This Autotransporter-associated beta strand repeat model represents a core 32-residue region of a class of bacterial protein repeat found in one to 30 copies per protein. Most proteins with a copy of this repeat have domains associated with membrane autotransporters ([pfam:PF03797]). The repeats occur with a periodicity of 60 to 100 residues. A pattern of sequence conservation is that every second residue is well-conserved across most of the domain.  These repeats as likely to have a beta-helical structure. This repeat plays a role in the efficient transport of autotransporter virulence factors to the bacterial surface during growth and infection. The repeat is always associated with the passenger domain of the autotransporter. For these reasons it has been coined the Passenger-associated Transport Repeat (PATR). The mechanism by which the PATR motif promotes transport is uncertain but it is likely that the conserved glycines (see HMM Logo) are required for flexibility of folding and that this folding drives secretion. Autotransporters that contain PATR(s) associate with distinct virulence traits such as subtilisin (S8) type protease domains and polymorphic outer-membrane protein repeats, whilst SPATE (S6) type protease and lipase-like autotransporters do not tend to contain PATR motifs.
Pfam PF21725: Putative T7SS secretion signal domain (domain)
This alpha helical domain is likely to mediate secretion via a type VII secretion system due to similarity to [pfam:PF06013].
Pfam PF15040: Humanin family (family)
This family of proteins is found exclusively in humans. Humanin is a short anti-apoptotic peptide that interacts with Bax.
Pfam PF23921: Domain of unknown function (DUF7260) (domain)
This domain is found in uncharacterised proteins from Halobacteria. It is predicted to adopt a globular structure composed mainly of alpha-helices.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF24547: Domain of unknown function (DUF7601) (domain)
This domain is found in tandem in a number of bacterial proteins which are likely associated with the bacterial cell surface. It is predicted to fold into a beta-sandwich. Some members of this entry are likely to contain an intramolecular isopeptide bond connecting their N- and C-terminal strands. This family is closely related to [pfam:PF19407].
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF05334: Protein of unknown function (DUF719) (family)
This family consists of several eukaryotic proteins of unknown function.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF25089: Domain of unknown function (DUF7804) (domain)
This domain is found in uncharacterised plant proteins. It is predicted to fold into a globular structure consisting of a antiparallel beta-sheet curved around a central alpha-helix.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF05547: Immune inhibitor A peptidase M6, catalytic domain (domain)
The insect pathogenic Gram-positive Bacillus thuringiensis secretes immune inhibitor A, a metallopeptidase, which specifically cleaves host antibacterial proteins. A homologue of immune inhibitor A, PrtV, has been identified in the Gram-negative human pathogen Vibrio cholerae. The structure revealed four domains: a pro-peptide, a catalytic domain (represented in this entry), a domain reminiscent of viral envelope glycoproteins (VEG) and a MAM domain grafted into the latter.
Pfam PF15727: Domain of unknown function (DUF4678) (family)
This family of proteins is found in eukaryotes. Proteins in this family are typically between 318 and 395 amino acids in length.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF23019: Family of unknown function (DUF7033) (domain)
This uncharacterised domain is found in a group of polysaccharide deacetylases and similar proteins from bacteria. It is predicted to adopt an alpha-helical configuration.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF05956: APC basic domain (family)
This region of the APC family of proteins is known as the basic domain. It contains a high proportion of positively charged amino acids and interacts with microtubules.
Pfam PF21985: TR61B FKBP-like domain (domain)
This is the FKBP-like domain found towards the N-terminal of TR61B (tRNA (adenine(58)-N(1))-methyltransferase from human and similar proteins. This mitochondrion-specific protein catalyses the formation of N1-methyladenine at position 58 (m1A58) in various tRNAs and the formation of 1-methyladenosine at position 947 of mitochondrial 16S ribosomal RNA which is most likely important for mitoribosomal structure and function. TR61B is most similar to bacterial TrmI than to eukaryotic Trmt61A, according to phylogenetic tree analysis. The function of this domain is not clear but it may be necessary for overall folding and full enzymatic activity.
Pfam PF05585: Putative peptidase (DUF1758) (family)
This is a family of nematode proteins of unknown function. However, it seems likely that these proteins act as aspartic peptidases.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF10000: ACT domain (domain)
This domain, found in various hypothetical bacterial proteins, has no known function. However, its structure is similar to the ACT domain which suggests that it binds to amino acids and regulates other protein activity. This family was formerly known as DUF2241.
Pfam PF04197: Birnavirus RNA dependent RNA polymerase (VP1), palm domain (domain)
Birnaviruses are dsRNA viruses. This entry corresponds to the "palm" domain of the RNA dependent RNA polymerase, also known as VP1. All of the birnavirus VP1 proteins contain conserved RdRp motifs that reside in the catalytic "palm" domain of all classes of polymerases. However, the birnavirus RdRps lack the highly conserved Gly-Asp-Asp (GDD) sequence, a component of the proposed catalytic site of this enzyme family that exists in the conserved motif VI of the palm domain of other RdRps. The catalytic motifs are arranged in a permuted order in sequence.
Wikipedia: Birnaviridae is a family of double-stranded RNA viruses. Salmonid fish, birds and insects serve as natural hosts. There are currently 11 species in this family, divided among seven genera. Diseases associated with this family include infectious pancreatic necrosis in salmonid fish, which causes significant losses to the aquaculture industry, with chronic infection in adult salmonid fish and acute viral disease in young salmonid fish.
Pfam PF06744: Type VI secretion protein IcmF C2-like domain (domain)
IcmF_C family represents a conserved region situated towards the C-terminal end of IcmF-like proteins. It was thought to be involved in Vibrio cholerae cell surface reorganisation that results in increased adherence to epithelial cells leading to an increased conjugation frequency. IcmF as a whole interacts with DotU whereby these bind tightly and form the docking area of the T6SS within the inner membrane.  The exact function of this domain is not clear.
Pfam PF09175: Vitellinogen, beta-sheet shell (domain)
This entry represents the beta-sheet shell domain found in vitellinogen, which generally corresponds to the lipovitellin-2 peptide product. This domain consists of several large open beta-sheets.
Pfam PF09968: Uncharacterized protein domain (DUF2202) (domain)
This domain is found in Uncharacterized protein MJ0754 from Methanocaldococcus jannaschii and similar proteins from bacteria and archaea. MJ0754 adopts a dimeric assembly, with each monomer consisting of six alpha-helices. It is a member of a broad superfamily of ferritin-like diiron-carboxylate proteins whose function is unknown. The conserved residues of a diiron centre are present within the putative active site.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF01967: MoaC family (family)
Members of this family are involved in molybdenum cofactor biosynthesis. However their molecular function is not known.
Pfam PF14686: Polysaccharide lyase family 4, domain II (domain)
FnIII-like is domain II of rhamnogalacturonan lyase (RG-lyase). The full-length protein specifically recognises and cleaves alpha-1,4 glycosidic bonds between l-rhamnose and d-galacturonic acids in the backbone of rhamnogalacturonan-I, a major component of the plant cell wall polysaccharide, pectin. This domain displays an immunoglobulin-like or more specifically Fibronectin-III type fold and shows highest structural similarity to the C-terminal beta-sandwich subdomain of the pro-hormone/propeptide processing enzyme carboxypeptidase gp180 from duck. It serves to assist in producing the deep pocket, with domain III, into which the substrate fits.
Pfam PF16624: Unstructured region upstream of a zinc-finger (disordered)
zf-C2H2_assoc2 is a short region of natively unstructured sequence immediately upstream of a C2H2-type zinc-finger on eukaryotic Zinc-finger proteins 592 and 800.  The function is not known.
Pfam PF16005: KH-like RNA-binding domain (domain)
MOEP19 is a family of mammalian KH-like RNA-binding motifs. The family is expressed during early embryogenesis. It appears to effect an early form of molecular asymmetry within the murine oocyte cytoplasm. The family marks a defined cortical cytoplasmic domain in oocytes and provides evidence for mammalian oocyte polarity and a form of pre-patterning that persists in zygotes and early embryos through the morula stage.
Wikipedia: The K Homology (KH) domain is a protein domain that was first identified in the human heterogeneous nuclear ribonucleoprotein (hnRNP) K. An evolutionarily conserved sequence of around 70 amino acids, the KH domain is present in a wide variety of nucleic acid-binding proteins. The KH domain binds RNA, and can function in RNA recognition. It is found in multiple copies in several proteins, where they can function cooperatively or independently. For example, in the AU-rich element RNA-binding protein KSRP, which has 4 KH domains, KH domains 3 and 4 behave as independent binding modules to interact with different regions of the AU-rich RNA targets. The solution structure of the first KH domain of FMR1 and of the C-terminal KH domain of hnRNP K determined by nuclear magnetic resonance (NMR) revealed a beta-alpha-alpha-beta-beta-alpha structure. Autoantibodies to NOVA1, a KH domain protein, cause paraneoplastic opsoclonus ataxia. The KH domain is found at the N-terminus of the ribosomal protein S3. This domain is unusual in that it has a different fold compared to the normal KH domain.
Pfam PF21635: Helicase MOV-10, helical domain (domain)
Helicase MOV-10 is a 5'-3' RNA helicase required for RNA-mediated gene silencing by the RNA-induced silencing complex (RISC). It is involved in mRNA metabolism and translation, modulation of viral infectivity, inhibition of retrotransposition and regulation of synaptic transmission. It interacts with FMRP1 and regulates miRNA-mediated translational repression by AGO2. This is a presumed helical domain found between [pfam:PF21633] and [pfam:PF21634].
Pfam PF22365: PfNDH2 helical insertion domain (domain)
This entry represent the helical insertion domain of NDH2, a NADH-ubiquinone oxidoreductase from Plasmodium falciparum, an interesting target for antimalarial drug development. This domain seems to be present exclusively in Plasmodium sequences.
Pfam PF01983: Guanylyl transferase CofC like (family)
Coenzyme F420 is a hydride carrier cofactor that functions during methanogenesis.  This family of proteins represents CofC, a nucleotidyl transferase that is involved in coenzyme F420 biosynthesis.  CofC has been shown to catalyse the formation of lactyl-2-diphospho-5'-guanosine from 2-phospho-L-lactate and GTP.
Pfam PF08389: Exportin 1-like protein (repeat)
The sequences featured in this family are similar to a region close to the N-terminus of yeast exportin 1 (Xpo1, Crm1, [swissprot:P14068]). This region is found just C-terminal to an importin-beta N-terminal domain ([pfam:PF03810]) in many members of this family. Exportin 1 is a nuclear export receptor that interacts with leucine-rich nuclear export signal (NES) sequences, and Ran-GTP, and is involved in translocation of proteins out of the nucleus.
Pfam PF10123: Mu-like prophage I protein (family)
Members of this family of proteins comprise various viral Mu-like prophage I proteins.
Pfam PF20754: Thermo-DBP-RP2 C-terminal domain (domain)
This domain is found in proteins from archaea, including ThermoDBP- related protein (ThermoDBP-RP) 2 from hyperthermophilic crenarchaea. This protein shows great affinity in vitro for single-stranded DNA and consists of two globular domains. The C-terminal domain (this entry) is composed of a five-stranded, anti-parallel beta sheet sandwiched between two alpha helices.
Pfam PF14082: Shedu protein SduA, C-terminal (domain)
This domain is found mostly in bacteria. It is found at the C-terminal of Shedu protein SduA, the only component of antiviral defense system Shedu. Expression of Shedu in B.subtilis (strain BEST7003) confers resistance to phages phi105, phi29, rho14 and to a lesser extent to SPP1. This domain may have endonuclease activity.
Pfam PF18021: Agglutinin C-terminal (domain)
This is the C-terminal domain of the alpha chain found in Marasmius Oreades lectin protein (MOA) which binds specifically with Gal.alpha(1,3)Gal-containing sugar epitopes. The enzymatic activity of the MOA may be associated with this domain. The domain has an alpha/beta-fold, which features a central six-stranded, mostly anti-parallel, beta-sheet flanked by three alpha-helices, and a short two-stranded beta-sheet.
Pfam PF10655: Hypothetical protein of unknown function (DUF2482) (family)
All the members of this very small, very short family are derived from bacteriophages, of the SA bacteriophages 11, Mu50B, system, and from the Staphylococcal_phi-Mu50B-like_prophages subsystem. All members are hypothetical proteins.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.