SII-SWORD/CoKE huggingface dataset:
Pfam PF23403: LTI65/LTI78 CAP160 N-terminal (disordered)
This entry represents a disordered region found at the N-terminal of LTI65/LTI78 ([pfam:PF07918]) from Arabidopsis thaliana and similar  sequences from plants. This domain is enriched in V/K/H/E/D amino acids. These proteins are involved in responses to abiotic stresses.
Pfam PF15747: Domain of unknown function (DUF4687) (family)
This family of proteins is found in eukaryotes. Proteins in this family are typically between 76 and 140 amino acids in length.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF17390: Bacterial alpha-L-rhamnosidase C-terminal domain (domain)
This family consists of bacterial rhamnosidase A and B enzymes. L-Rhamnose is abundant in biomass as a common constituent of glycolipids and glycosides, such as plant pigments, pectic polysaccharides, gums or biosurfactants. Some rhamnosides are important bioactive compounds. For example, terpenyl glycosides, the glycosidic precursor of aromatic terpenoids, act as important flavouring substances in grapes. Other rhamnosides act as cytotoxic rhamnosylated terpenoids, as signal substances in plants or play a role in the antigenicity of pathogenic bacteria.
Wikipedia: In molecular biology, glycoside hydrolase family 78 is a family of glycoside hydrolases.
Pfam PF24813: Domain of unknown function (DUF7709) (domain)
This domain is found in uncharacterised proteins. It is predicted to adopt a globular structure consisting of array of helices followed by a beta-hairpin.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF03692: Putative zinc- or iron-chelating domain (family)
This family of proteins contains 8 conserved cysteines. It has in the past been annotated as being one of the complex of proteins of the flagellar Fli complex.  However this was due to a mis-annotation of the original Salmonella LT2 Genbank entry of 'fliB'. With all its conserved cysteines it is possibly a domain that chelates iron or zinc ions.
Pfam PF19107: Family of unknown function (DUF5794) (family)
This is a family of proteins of unknown function predominantly found in Halobacteria.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF23401: Card1 hinge domain (domain)
This is the hinge domain found in a set of bacterial proteins, including Card1 (cyclic-oligoadenylate-activated single-stranded ribonuclease and single-stranded deoxyribonuclease 1) from Treponema succinifaciens ([swissprot:F2NWD3]), a protein that is part of type III CRISPR-Cas immune response system. This protein consists of a CARF (CRISPR-associated Rossmann fold) domain at the N-terminal, an helical hinge domain and a C-terminal endonuclease domain ([pfam:PF09002]).
Pfam PF14097: Stage V sporulation protein AE1 (family)
Members of this family are all described as putative stage V sporulation protein AE, although this could not be confirmed. Proteins in this family are approximately 190 amino acids in length.
Pfam PF03228: Adenoviral core protein VII (family)
The function of this protein is unknown. It has a conserved amino terminus of 50 residues followed by a positively charged tail, suggesting it may interact with nucleic acid. The major core protein of the adenovirus, protein VII, was found to be associated with viral DNA throughout infection. The precursor to protein VII were shown to be in vivo and in vitro acceptors of ADP-ribose. The ADP-ribosylated core proteins were assembled into mature virus particles. ADP-ribosylation of adenovirus core proteins may have a role in virus decapsidation.
Pfam PF06466: PCAF (P300/CBP-associated factor) N-terminal domain (domain)
This region is spliced out of [swissprot:Q92830] isoform 2. It is predicted to be of a mixed alpha/beta fold -  though predominantly helical.
Pfam PF15528: Bacterial toxin 23 (family)
A predicted RNase toxin found in bacterial polymorphic toxin systems.  The toxin possesses an all-beta fold and conserved ND and DxxR motifs and a histidine residue. In bacterial polymorphic toxin systems, the toxin is exported by the type 2 or TcdB/TcaC secretion system.
Pfam PF15672: Cell-membrane associated Mucin15 (family)
Mucin15 is a family of vertebrate mucins associated with the cell-membrane. The function is not known.  Members of the family are typically between 284 and 335 amino acids in length.
Pfam PF09259: Fungal immunomodulatory protein Fve (domain)
Fve is a major fruiting body protein from Flammulina velutipes, a mushroom possessing immunomodulatory activity. It stimulates lymphocyte mitogenesis, suppresses systemic anaphylaxis reactions and oedema, enhances transcription of IL-2, IFN-gamma and TNF-alpha, and haemagglutinates red blood cells. It appears to be a lectin with specificity for complex cell-surface carbohydrates. Fve adopts a tertiary structure consisting of an immunoglobulin-like beta-sandwich, with seven strands arranged in two beta sheets, in a Greek-key topology. It forms a non-covalently linked homodimer containing no Cys, His or Met residues; dimerisation occurs by 3-D domain swapping of the N-terminal helices and is stabilised predominantly by hydrophobic interactions.
Pfam PF08764: Staphylococcus aureus coagulase (domain)
Staphylococcus aureus secretes a cofactor called coagulase. Coagulase is an extracellular protein that forms a complex with human prothrombin, and activates it without the usual proteolytic cleavages.  The resulting complex directly initiates blood clotting.
Pfam PF02959: HTLV Tax (family)
Human T-cell leukaemia virus type I (HTLV-I) is the etiological agent for adult T-cell leukaemia (ATL), as well as for tropical spastic paraparesis (TSP) and HTLV-I associate myelopathy (HAM). A biological understanding of the involvement of HTLV-I and in ATL has focused significantly on the workings of the virally-encoded 40 kDa phospho-oncoprotein, Tax. Tax is a transcriptional activator. Its ability to modulate the expression and function of many cellular genes has been reasoned to be a major contributory mechanism explaining HTLV-I-mediated transformation of cells. In activating cellular gene expression, Tax impinges upon several cellular signal-transduction pathways, including those for CREB/ATF and NF-kappaB.
Pfam PF20296: Methylase-associated X1 (domain)
This is a globular domain found across several restriction- modification systems.
Pfam PF24089: Family of unknown function (DUF7374) (family)
This entry represents a small family of uncharacterised phage proteins. Structure prediction suggests that this protein dimerises.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF16421: E2F transcription factor CC-MB domain (domain)
This is the coiled coil (CC) - marked box (MB) domain of E2F transcription factors. This domain forms a heterodimer with the corresponding domain of the DP transcription factor, the heterodimer binds the C-terminus of retinoblastoma protein.
Pfam PF12698: ABC-2 family transporter protein (family)
This family is related to the ABC-2 membrane transporter family [pfam:PF01061].
Wikipedia: The ABC transporters, ATP synthase (ATP)-binding cassette transporters are a transport system superfamily that is one of the largest and possibly one of the oldest gene families. It is represented in all extant phyla, from prokaryotes to humans. ABC transporters belong to translocases.
Pfam PF06059: Domain of Unknown Function (DUF930) (family)
Family of bacterial proteins with undetermined function.  All bacteria in this family are from the Rhizobiales order.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF15361: Resistance to inhibitors of cholinesterase homologue 3 (family)
RIC3 is a protein associated with nicotinic acetylcholine receptors (nAChRs), neurotransmitter-gated ion channels expressed at the neuromuscular junction and within the central and peripheral nervous systems. It can enhance functional expression of multiple nAChR subtypes. RIC3 promotes functional expression of homomeric alpha-7 and alpha-8 nicotinic acetylcholine receptors at the cell surface.
Pfam PF12607: Protein of unknown function (DUF3772) (family)
This domain family is found in bacteria, and is approximately 60 amino acids in length. The family is found in association with [pfam:PF00924].
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF08286: Spc24 subunit of Ndc80 (family)
Spc24 is a component of the evolutionarily conserved kinetochore-associated Ndc80 complex and is involved in chromosome segregation
Pfam PF20278: C-terminal domain 2 of the ABC-three component (ABC-3C) systems (domain)
C-terminal domains (CTDs) of ABC-3C systems, contain distinct patterns of charged and polar residues and are not yet unifiable with known domains. These domains are found at the C-terminus of the effector component of the systems, which are upstream of the Middle Component and ABC ATPase components on the genome. Due to the typically large size of these CTDs relative to the actual effector and MC domains, the CTDs are predicted to serve as the platform on which the remaining two components assemble. Therewith, conformational changes transmitted by the ABC ATPase-mediated detection of invasive elements like DNA viruses would result in an unfurling and activation of the CTD-associated effector.
Pfam PF16314: Domain of unknown function (DUF4954) (repeat)
This entry consists of an uncharacterised domain found in proteins of around 660 residues in length and is mainly found in various Bacteroides species. The function of these proteins is unknown. This domain consists of repeated strands.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF04294: VanW like protein (family)
Family members include vancomycin resistance protein W (VanW). Genes encoding members of this family have been found in vancomycin  resistance gene clusters vanB and vanG.  The function of VanW is  unknown.
Pfam PF12014: Cyclin D1 binding domain (domain)
Ubiquitin-dependent proteolysis of cyclin D1 is associated with normal and tumour cell proliferation and survival. The best characterised member of this family is the SCF FBXO31 (Skp1-Cul1-Rbx1-FBXO31) ubiquitin ligase complex mediates genotoxic stress-induced cyclin D1 degradation. FBXO31 possesses a unique substrate-binding beta barrel domain, whereas cyclin D1 binds to FBXO31 by tucking its free C-terminal carboxylate tail into an open cavity of the C-terminal FBXO31 beta-barrel. Biophysical and functional studies demonstrated that SCFFBXO31 is capable of recruiting and ubiquitinating cyclin D1 in a phosphorylation-independent manner.
Pfam PF06653: Tight junction protein, Claudin-like (family)
This is a family of probable membrane tight junction, Claudin-like, proteins.
Wikipedia: Claudins are a family of proteins which, along with occludin, are the most important components of the tight junctions. Tight junctions establish the paracellular barrier that controls the flow of molecules in the intercellular space between the cells of an epithelium. They have four transmembrane domains, with the N-terminus and the C-terminus in the cytoplasm.
Pfam PF15819: Fin bud initiation factor homologue (family)
Fibin is a family of eukaryotic proteins expressed in the lateral plate mesoderm of presumptive pectoral fin bud regions. It acts as a signal molecule for the expression of Tbx5, a gene involved in the specification of fore-limb identity. Fibin is found to be expressed in cerebellum, skeletal muscle and many other embryonic as well as adult mouse tissues, suggesting roles in both embryogenesis and in adult life. Although Fibin is routed through the endoplasmic reticulum (ER) no significant evidence for secretion is found. Fibin is post-translationally modified and forms dimers when expressed heterologously and its expression is regulated by a number of cellular signalling pathways.
Pfam PF18474: Family of unknown function (DUF5614) (domain)
This is an N-terminal domain found in C7orf25 protein UPF0415. It is distantly related to the PD-(D/E)XK nucleases.
Wikipedia: C7orf25 protein UPF0415 (UPF0415) is a protein encoded on chromosome 7, in open reading frame 25 (C7orf25) and are located at domain of unknown function 1308. C7orf25 is located at the minus strand and encodes 12 proteins, one of them being UPF0415. This protein is believed to be active in the proteosome pathway. C7orf25 protein UPF0415 is not a transmembrane protein and has no signal peptide. UPF0415 has two isoforms, Q9BPX7-1 and Q9BPX7-2. Both consists of two exons that are both highly conserved among vertebrates.
Pfam PF07921: Fibritin C-terminal region (family)
This family features sequences bearing similarity to the C-terminal portion of the bacteriophage T4 protein fibritin ([swissprot:P10104]). This protein is responsible for attachment of long tail fibres to virus particle, and forms the 'whiskers' or fibres on the neck of the virion. The region seen in this family contains an N-terminal coiled-coil portion and the C-terminal globular foldon domain (residues 457-486), which is essential for fibritin trimerisation and folding. This domain consists of a beta-hairpin; three such hairpins come together in a beta-propeller-like arrangement in the trimer, which is stabilised by hydrogen bonds, salt bridges and hydrophobic interactions.
Pfam PF23546: DNA topoisomerase 3-beta zinc ribbon domain (domain)
This domain is found in human DNA topoisomerase 3-beta (TOP3B) and related proteins. TOP3B, a recently identified member of the topoisomerase superfamily, is essential for chromosome stability, including in cancer cells. The domain represented by this entry is predicted to adopt a zinc ribbon fold. It contains a pair of invariant CxxC sequence motifs.
Pfam PF07352: Bacteriophage Mu Gam like protein (family)
This family consists of bacterial and phage Gam proteins. The gam gene of bacteriophage Mu encodes a protein which protects linear double stranded DNA from exonuclease degradation in vitro and in vivo.
Pfam PF01280: Ribosomal protein L19e (family)
This entry represents a structural domain of large ribosomal subunit protein eL19, found in archaea and eukaryotes .
Pfam PF03119: NAD-dependent DNA ligase C4 zinc finger domain (domain)
DNA ligases catalyse the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilising either ATP or NAD(+) as a cofactor. This family is a small zinc binding motif that is presumably DNA binding. IT is found only in NAD dependent DNA ligases.
Pfam PF21633: Helicase MOV-10, Ig-like domain (domain)
Helicase MOV-10 is a 5'-3' RNA helicase required for RNA-mediated gene silencing by the RNA-induced silencing complex (RISC). It is involved in mRNA metabolism and translation, modulation of viral infectivity, inhibition of retrotransposition and regulation of synaptic transmission. It interacts with FMRP1 and regulates miRNA-mediated translational repression by AGO2. The function of this domain is unknown. According to structure predictions, it seems to adopt an Ig-like fold.
Pfam PF11681: Bacteriophage KPP10, Structural protein ORF10 (family)
This family is represented by Bacteriophage KPP10, Structural protein ORF10, whose function is unknown. The characteristics of the protein distribution suggest prophage matches in addition to the phage matches.
Pfam PF11815: Domain of unknown function (DUF3336) (family)
This family of proteins are functionally uncharacterised. This family is found in bacteria and eukaryotes. This presumed domain is typically between 143 to 227 amino acids in length.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF01451: Low molecular weight phosphotyrosine protein phosphatase (domain)
Protein tyrosine (pTyr) phosphorylation is a common post-translational modification which can create novel recognition motifs for protein interactions and cellular localisation, affect protein stability, and regulate enzyme activity. Consequently, maintaining an appropriate level of protein tyrosine phosphorylation is essential for many cellular functions. Tyrosine-specific protein phosphatases (PTPase; 3.1.3.48) catalyse the removal of a phosphate group attached to a tyrosine residue, using a cysteinyl-phosphate enzyme intermediate. These enzymes are key regulatory components in signal transduction pathways (such as the MAP kinase pathway) and cell cycle control, and are important in the control of cell growth, proliferation, differentiation and transformation . The PTP superfamily can be divided into four subfamilies :


 * (1) pTyr-specific phosphatases
 * (2) dual specificity phosphatases (dTyr and dSer/dThr)
 * (3) Cdc25 phosphatases (dTyr and/or dThr)
 * (4) LMW (low molecular weight) phosphatases


Based on their cellular localisation, PTPases are also classified as:


 * Receptor-like, which are transmembrane receptors that contain PTPase domains 
 * Non-receptor (intracellular) PTPases 


All PTPases carry the highly conserved active site motif C(X)5R (PTP signature motif), employ a common catalytic mechanism, and share a similar core structure made of a central parallel Î²-sheet with flanking Î±-helices containing a Î²-loop-Î±-loop that encompasses the PTP signature motif . Functional diversity between PTPases is endowed by regulatory domains and subunits.
This entry represents the low molecular weight (LMW) protein-tyrosine phosphatases (or acid phosphatase), which act on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates . The structure of a LMW PTPase has been solved by X-ray crystallography  and is found to form a single structural domain. It belongs to the Î±/Î² class, with 6 Î±-helices and 4 Î²-strands forming a 3-layer Î±-Î²-Î± sandwich architecture.
Wikipedia: Protein tyrosine phosphatases (EC	3.1.3.48, systematic name protein-tyrosine-phosphate phosphohydrolase) are a group of enzymes that remove phosphate groups from phosphorylated tyrosine residues on proteins:[a protein]-tyrosine phosphate + H2O = [a protein]-tyrosine + phosphate
Pfam PF05875: Ceramidase (family)
This family consists of several ceramidases. Ceramidases are enzymes involved in regulating cellular levels of ceramides, sphingoid bases, and their phosphates, [ec:3.5.1.23]. This family belongs to the CREST superfamily, which are distantly related to the GPCRs.
Pfam PF05335: Protein of unknown function (DUF745) (coiled_coil)
This family consists of several uncharacterised Drosophila melanogaster proteins of unknown function.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF23772: Phage g100-like protein (domain)
This entry includes Yersinia phage phiR1-RT g100 protein [swissprot:I7LH63] which shows a partial beta barrel topology according to AlphaFold prediction. The function of members of this family is unknown.
Pfam PF24522: KRIT1/FRMD8, FERM domain C-lobe (domain)
KRIT1, also known as CCM1, a Rap1-binding protein, is expressed in endothelial cells where it is present in cell-cell junctions and associated with junctional proteins. Together with CCM2/MGC4607 and CCM3/PDCD10, KRIT1 constitutes a set of proteins whose mutations are found in cerebral cavernous malformations, characterised by cerebral hemorrhages and vascular malformations in the central nervous system. KRIT1 localization is mediated by its FERM domain. This entry represents the FERM domain C-lobe. This entry also includes the paralogue of KRIT1, FRMD8, a protein that promotes the cell surface stability of iRhom1/RHBDF1 and iRhom2/RHBDF2 and prevents their degradation via the endolysosomal pathway. By acting on iRhoms, FRMD8 is involved in ADAM17-mediated shedding of TNF, amphiregulin/AREG, HBEGF and TGFA from the cell surface.
Pfam PF17041: E domain (domain)
This short domain is about 50 amino acids in length.  Its structure shows that it is composed of two beta sheets each of three strands. This domain is found associated with the [pfam:PF07501] domain and it has structural similarity with that domain although it is somewhat shorter. The E domain forms part of a rod like structure.