SII-SWORD/CoKE huggingface dataset:
Pfam PF09379: FERM N-terminal domain (domain)
This domain is the N-terminal ubiquitin-like structural domain of the FERM domain.
Wikipedia: In molecular biology, the FERM domain is a widespread protein module involved in localising proteins to the plasma membrane. FERM domains are found in a number of cytoskeletal-associated proteins that associate with various proteins at the interface between the plasma membrane and the cytoskeleton. The FERM domain is located at the N terminus in the majority of proteins in which it is found.
Pfam PF15537: Bacterial toxin 43 (family)
A predicted RNase toxin found in bacterial polymorphic toxin systems.  The toxin possesses an alpha+beta fold with two conserved histidine residues. In bacterial polymorphic toxin systems, the toxin is usually exported by the type 2 or TcdB/TcaC-type secretion system. An example of this, the Pseudomonas RhsT-C, has been experimentally characterised.
Pfam PF16476: Domain of unknown function (DUF5053) (family)
This family consists of C-terminal of uncharacterized proteins around 100 residues in length and is mainly found in various Prevotella species. The function of this family is unknown.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF05854: Non-histone chromosomal protein MC1 (family)
This family consists of archaeal chromosomal protein MC1 sequences which protect DNA against thermal denaturation.
Pfam PF12960: Protein of unknown function (DUF3849) (domain)
A family of uncharacterized proteins found by clustering human gut metagenomic sequences. This domain frequently seen with DUF3848.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF20643: TAF1C, C-terminal domain (domain)
This is the C-terminal domain of TAF1C (TATA box-binding protein-associated factor RNA polymerase I subunit C) from mammals, the orthologue of yeast Rrn6. TAF1C is a component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (preinitiation complex) during RNA polymerase I-dependent transcription.
Pfam PF15974: Cadherin C-terminal cytoplasmic tail, catenin-binding region (family)
Cadherin_tail is the cytoplasmic domain at the C-terminus of cadherin proteins. This domain binds p120 catenin, an action critical for the surface stability of cadherin-catenin cell-cell adhesion complexes.
Pfam PF20930: Dicer, partner-binding domain (domain)
This domain is found in Endoribonuclease Dicer from chordates. This dsRNA endoribonuclease is involved in the cleavage of long RNA precursors into short dsRNAs and plays a role in gene silencing. Dicer shows two N-terminal helicase domains ([pfam:PF04851] and [pfam:PF00271]), a dimerisation domain ([pfam:PF03368]), a Platform domain, a PAZ domain ([pfam:PF02170]), two RNase III a/b domains ([pfam:PF00636]) and a dsRNA-binding domain in its C-terminal region. This entry represents the partner-binding domain, which folds into a four-helix bundle. It is is responsible for the interactions with the dsRNA-binding proteins that support the enzymatic activity of Dicer.
Pfam PF13060: Protein of unknown function (DUF3921) (family)
This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 60 amino acids in length.
Pfam PF16269: Domain of unknown function (DUF4922) (family)
This family consists of uncharacterised proteins around 310 residues in length and is mainly found in various Bacteroides and Parabacteroides species. Several members are annotated as putative glycosyltransferases, but the specific function of this family is still unknown.
Pfam PF21589: AP-5 complex subunit beta-1, beta-barrel (domain)
AP5B1 is part of the AP-5 adaptor protein complex, which may be involved in endosomal transport. This entry represents a beta-barrel domain found towards the C-terminal region of AP5B1. Structure predictions suggests that it contains seven antiparallel beta-strands.
Pfam PF17514: Family of unknown function (DUF5442) (family)
This is a family of unknown function found in Chironomus.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF14206: Cysteine-rich CPCC (family)
This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria, archaea, eukaryotes and viruses.  Proteins in this family are typically between 68 and 104 amino acids in length. There are six conserved cysteines and a conserved CPCC sequence motif.
Pfam PF13685: Iron-containing alcohol dehydrogenase (family)
This entry includes glycerol-1-phosphate dehydrogenases (G1PDH) from archaea and bacteria. G1PDH catalyses the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol 1-phosphate (G1P) .
Pfam PF20953: Phage tail base-plate attachment protein C-terminal insertion domain (domain)
Caudo_bapla16 is a family of ORF16 tail-phage P2-like proteins that forms part of the base-plate at the tip of the phage tail. The whole base-plate complex is involved in host recognition and attachment, and consists of several proteins derived from consecutive open-reading-frames. This entry represents the insertion domain found within the C-terminal RIFT barrel domain.
Pfam PF12841: YvrJ protein family (family)
This family of short proteins are related to B. subtilis YvrJ protein. None of the members of this family have been functionally characterised.
Pfam PF21262: Exosome complex component RRP40, S1 domain (domain)
RRP40 is a non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. It consists of a N-terminal beta-sandwich hybrid domain ([pfam:PF21261]), a central S1 domain and a C-terminal KH domain ([pfam:PF15985]). This entry represents the S1 RNA binding domain, which has an OB fold.
Pfam PF15527: Bacterial toxin 22 (family)
A predicted RNase toxin found in bacterial polymorphic toxin systems.  The toxin possesses a mostly beta fold and two conserved histidines, two aspartates and a glutamate residue. In bacterial polymorphic toxin systems, the toxin is usually exported by the type 5 secretion system.
Pfam PF18900: Protein of unknown function (DUF5656) (family)
This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 237 and 274 amino acids in length. These proteins are likely to be integral membrane proteins.
Pfam PF20526: Domain of unknown function (DUF6741) (domain)
This presumed domain is functionally uncharacterised. This domain family is found in fungi, and is approximately 130 amino acids in length.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF22991: Gag1-like, lock domain (domain)
This domain found in Gag1 from Saccharomyces cerevisiae and similar fungal sequences. Gag1 interacts with Cka2, the fourth subunit of the eukaryotic kinase CK2. This protein is organised into three domains: lock (this entry), Gag and Clap ([pfam:PF13259]). This short domain is predicted to adopt a predominantly alpha-helical configuration.
Pfam PF21855: Treslin, STD domain (domain)
This entry represents the STD (Sld3-Treslin domain) domain from treslin, the metazoan counterpart of Sld3 from yeast, which are the hub proteins mediating protein associations critical for the helicase formation. Treslin, as Sld3, interacts with TopBP1 in a Cdk2-dependent manner, which then collaborate in the Cdk2-mediated loading of Cdc45 onto replication origins. Treslin and Sld3 differ in their molecular sizes and amino acid sequences, however, they share this conserved Sld3/Treslin domain (STD), essential for replication origin firing. According to their similarities, it has been suggested that helicase activation in mammals has diverged in complexity during evolution from that in yeasts and may involve additional partners that interact with TopBP1.
Pfam PF23371: Capsid protein Vp24 (family)
This entry represents the capsid Vp24 protein from apple-latent spherical virus (ALSV) and related picorna-like plant viruses. This protein is encoded in a polyprotein that is cleaved into three proteins, Vp25, Vp20 and Vp24 which all have jellyroll fold and form one protomer; 60 copies of this unit compose one virion. Vp25, Vp20 and Vp24 contribute to capsid stabilization. Vp24 form a pentameric protrusion around a fivefold axis, and the protrusion sits on a base of Vp25 and Vp20. Vp24 is more loosely held and is supported by Vp25 nd Vp20.
Pfam PF17763: Glutaminase/Asparaginase C-terminal domain (domain)
This domain is found at the C-terminus of asparaginase enzymes.
Pfam PF17470: Phage gene product 45.2 (family)
This is a family of unknown function found in Myoviridae.
Pfam PF24080: AP-3 complex subunit beta-1, C-terminal domain (domain)
This domain is found at the C-terminal end of human AP-3 complex subunit beta-1 (AP3B1) and similar eukaryotic proteins. AP3B1 is a subunit of non-clathrin- and clathrin-associated AP-3 complex, which plays a role in protein sorting in the late-Golgi/trans -Golgi network (TGN) and/or endosomes. This domain is predicted to adopt a structure consisting of a 5 stranded beta-sheet, flanked by one-alpha helix on the outer side, and by two alpha -helices on the inner side.
Pfam PF02907: Hepatitis C virus NS3 protease (domain)
Hepatitis C virus NS3 protein is a serine protease which has a trypsin-like fold.  The non-structural (NS) protein NS3 is one of the NS proteins involved in replication of the HCV genome. NS2-3 proteinase, a zinc-dependent enzyme, performs a single proteolytic cut to release the N-terminus of NS3.  The action of NS3 proteinase (NS3P), which resides in the N-terminal one-third of the NS3 protein, then yields all remaining non-structural proteins.  The C-terminal two-thirds of the NS3 protein contain a helicase. The functional relationship between the proteinase and helicase domains is unknown. NS3 has a structural zinc-binding site and requires cofactor NS4A.
Pfam PF20085: Protein-glutamine gamma-glutamyltransferase (domain)
This entry represents a protein-glutamine gamma-glutamyltransferase which may play a role in the assembly of the spore coat proteins by catalysing epsilon-(gamma-glutamyl)lysine cross-links.
Pfam PF03420: Prohead core protein serine protease (family)
This group of peptidases belongs to MEROPS peptidase family U9 (phage prohead processing peptidase family, clan U-), which play a role in the head assembly of Bacteriophage T4.
The peptidases families associated with clan U-have an unknown catalytic mechanism as the protein fold of the active site domain and the active site residues have not been reported.
Pfam PF03455: dDENN domain (domain)
This region is always found associated with [pfam:PF02141]. It is predicted to form a globular domain. Although not statistically supported it has been suggested that this domain may be similar to members of the Rho/Rac/Cdc42 GEF family. This N-terminal region of DENN folds into a longin module, consisting of a central antiparallel beta-sheet layered between helix H1 and helices H2 and H3 (strands S1-S5). Rab35 interacts with dDENN via residues in helix 1 and in the loop S3-S4.
Pfam PF06553: BNIP3 (family)
This family consists of several mammalian specific BCL2/adenovirus E1B 19-kDa protein-interacting protein 3 or BNIP3 sequences. BNIP3 belongs to the Bcl-2 homology 3 (BH3)-only family, a Bcl-2-related family possessing an atypical Bcl-2 homology 3 (BH3) domain, which regulates PCD from mitochondrial sites by selective Bcl-2/Bcl-XL interactions. BNIP3 family members contain a C-terminal transmembrane domain that is required for their mitochondrial localisation, homodimerisation, as well as regulation of their pro-apoptotic activities. BNIP3-mediated apoptosis has been reported to be independent of caspase activation and cytochrome c release and is characterised by early plasma membrane and mitochondrial damage, prior to the appearance of chromatin condensation or DNA fragmentation.
Pfam PF18291: HU domain fused to wHTH, Ig, or Glycine-rich motif (domain)
Rapidly-diverging family of HU domains predominantly observed in the bacteroidetes lineage with a predicted role in recognition and possible interception of the DNA of parasitic elements, a counter-conflict strategy preventing incorporation of these elements into the host genome.
Pfam PF04521: ssRNA positive strand viral 18kD cysteine rich protein (family)
This family represents the 18kDa cysteine-rich protein from ssRNA positive strand viruses.

This entry includes Suppressor of RNA silencing Q06392. This protein is a suppressor of RNA-mediated gene silencing, also known as post-transcriptional gene silencing (PTGS), a mechanism of plant viral defense that performs sequence-specific inhibition of viral mRNAs expression .
Pfam PF01258: Prokaryotic dksA/traR C4-type zinc finger (domain)
This domain is found in the members of the DksA/TraR family. It adopts a treble clef fold.
Pfam PF13257: Domain of unknown function (DUF4048) (family)
This presumed domain is functionally uncharacterised. This domain family is found in eukaryotes, and is typically between 228 and 257 amino acids in length.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF09615: CRISPR-associated protein (Cas_Csy3) (family)
CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) is a widespread family of prokaryotic direct repeats with spacers of unique sequence between consecutive repeats. This entry, typified by YPO2463 of Yersinia pestis, is a CRISPR-associated (Cas) entry strictly associated with the Ypest subtype of CRISPR/Cas locus. It is designated Csy3, for CRISPR/Cas Subtype Ypest protein 3.
Pfam PF05549: Allexivirus 40kDa protein (family)
This family of sequences contains the 40kDa polypeptides from garlic viruses (Allexiviruses), which do not resemble any other plant virus gene products reported so far .

Rod-shaped flexuous viruses have been isolated from garlic plants, Allium sativum. Infection by this virus creates typical mosaic symptoms. The core-like sequence of a zinc finger protein preceded by a cluster of basic amino acid residues shows similarities to the corresponding 12K proteins of the potexviruses and carlaviruses . Viral epidemics by allexiviruses are also known to be caused by aphids and eriophyid mites (Aceria tulipae) carrying Potyviruses, Carlaviruses, and Allexiviruses .
Pfam PF23197: AIR9 A9 domain (domain)
This entry represents an Ig-like domain known as the A9 domain that is repeated in the members included here, such as AIR9 from A. thaliana and related proteins from plants, in which it appears 10/11 times, which in other sequences, it appears 5/6 times such as AMP-ACTIVATED PROTEIN KINASE from Trypanosoma cruzi. AIR9 and TAN1 function redundantly to maintain POK1 at the division site to ensure correct cell wall placement and interactions between POK1 and AIR9 are important for division plane orientation and plant growth.
Pfam PF16558: Amino-terminal Zinc-binding domain of ubiquitin ligase E3A (domain)
The AZUL or amino-terminal zinc-binding domain of ubiquitin E3a ligase is found in eukaryotes, and is an unusual zinc-finger domain.  The final cysteine is usually mutated in Angelman syndrome patients. It is likely that AZUL plays a role in Ube3A substrate-recognition.
Pfam PF23311: Domain of unknown function (DUF7084) (domain)
This domain is found in a group of uncharacterised proteins mainly from Arthropods. This is a relatively small domain that is predicted to contain mainly alpha-helices.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF12689: Acid Phosphatase (family)
This family contains phosphatase enzymes and other proteins of the HAD superfamily.  It includes MDP-1 which is a eukaryotic magnesium-dependent acid phosphatase.
Pfam PF05725: FNIP Repeat (repeat)
This short repeat is predominantly found in proteins from mimivirus and lower eukaryotes, including Calmodulin-binding protein CmbB from Dictyostelium discoideum (Social amoeba).  It appears to be related to [pfam:PF00560] (personal obs:C Yeats). The alignment consists of two tandem repeats. It is termed the FNIP repeat after the pattern of conserved residues.
Pfam PF13055: Protein of unknown function (DUF3917) (family)
This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 90 amino acids in length.
Pfam PF07080: Protein of unknown function (DUF1348) (domain)
This family consists of several highly conserved hypothetical proteins of around 150 residues in length. The function of this family is unknown.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF11291: Protein of unknown function (DUF3091) (family)
This eukaryotic family of proteins has no known function.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF21186: Domain of unknown function (DUF6852) (domain)
This domain is found at the C-terminal end of BVU_3817 from Phocaeicola vulgatus ([swissprot:A6L6W4]) and similar proteins mostly found in Bacteroidetes. This domain shows an alpha/beta structure and is normally found associated with [pfam:PF18347]. Its function is unknown.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF04103: CD20-like family (family)
This family includes the CD20 protein and the beta subunit of the high affinity receptor for IgE Fc. The high affinity receptor for IgE is a tetrameric structure consisting of a single IgE-binding alpha subunit, a single beta subunit, and two disulfide-linked gamma subunits. The alpha subunit of Fc epsilon RI and most Fc receptors are homologous members of the Ig superfamily. By contrast, the beta and gamma subunits from Fc epsilon RI are not homologous to the Ig superfamily. Both molecules have four putative transmembrane segments and a probably topology where both amino- and carboxy termini protrude into the cytoplasm. This family also includes LR8 like proteins from humans, mice and rats. The function of the human LR8 protein is unknown although it is known to be strongly expressed in the lung fibroblasts. This family also includes sarcospan is a transmembrane component of dystrophin-associated glycoprotein. Loss of the sarcoglycan complex and sarcospan alone is sufficient to cause muscular dystrophy. The role of the sarcoglycan complex and sarcospan is thought to be to strengthen the dystrophin axis connecting the basement membrane with the cytoskeleton.
Wikipedia: In molecular biology, the CD20-like family of proteins includes the CD20 protein and the beta subunit of the high affinity receptor for IgE Fc, MS4A2. MS4A2 has a tetrameric structure consisting of a single IgE-binding alpha subunit, a single beta subunit, and two disulfide-linked gamma subunits. It has four putative transmembrane segments and a probable topology where both amino- and carboxy termini protrude into the cytoplasm. This family also includes LR8 like proteins from humans (TMEM176B), mice and rats. The function of the human LR8 protein is unknown although it is known to be strongly expressed in the lung fibroblasts. This family also includes sarcospan, a transmembrane component of dystrophin-associated glycoprotein. Loss of the sarcoglycan complex and sarcospan alone is sufficient to cause muscular dystrophy. The role of the sarcoglycan complex and sarcospan is thought to be to strengthen the dystrophin axis connecting the basement membrane with the cytoskeleton.
Pfam PF04788: Protein of unknown function (DUF620) (domain)
Family of uncharacterised proteins.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF09261: Alpha mannosidase middle domain (domain)
Members of this family adopt a structure consisting of three alpha helices, in an immunoglobulin/albumin-binding domain-like fold. They are predominantly found in the enzyme alpha-mannosidase.
Wikipedia: In molecular biology, glycoside hydrolase family 38 is a family of glycoside hydrolases.