SII-SWORD/CoKE huggingface dataset:
Pfam PF24029: Domain of unknown function (DUF7340) (domain)
This entry represents the C-terminal zinc binding domain of an uncharacterised family of phage proteins.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF00023: Ankyrin repeat (repeat)
Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.
Wikipedia: Ankyrins are a family of proteins that mediate the attachment of integral membrane proteins to the spectrin-actin based membrane cytoskeleton. Ankyrins have binding sites for the beta subunit of spectrin and at least 12 families of integral membrane proteins. This linkage is required to maintain the integrity of the plasma membranes and to anchor specific ion channels, ion exchangers and ion transporters in the plasma membrane. The name is derived from the Greek word ἄγκυρα (ankyra) for "anchor".
Pfam PF22199: FKBP26, IF domain (domain)
This domain is centrally located in Long-type peptidyl-prolyl cis-trans isomerase from Methanocaldococcus jannaschii (FKBP26) and similar archaeal sequences. FKBP26 catalyses the cis-trans isomerisation of peptidyl prolyl bonds and exhibits chaperone -like activity. The latter activity requires a 50-residue insertion (IF domain, for 'Insert-in-Flap', this entry) in the catalytic FKBP domain ([pfam:PF00254]). It resembles a fractured four-stranded beta-barrel with the first and second strands connected by a helix that partially covers the fracture. It shows a highly hydrophobic surface.
Pfam PF03028: Dynein heavy chain region D6 P-loop domain (domain)
This family represents the C-terminal region of dynein heavy chain.  The chain also contains ATPase activity and microtubule binding ability and acts as a motor for the movement of organelles and vesicles along microtubules. Dynein is also involved in cilia and flagella movement. The dynein subunit consists of at least two heavy chains and a number of intermediate and light chains. The 380 kDa motor unit of dynein belongs to the AAA class of chaperone-like ATPases. The core of the 380 kDa motor unit contains a concatenated chain of six AAA modules, of which four correspond to the ATP binding sites with P-loop signatures described previously, and two are modules in which the P loop has been lost in evolution. This C-terminal domain carries the D6 region of the dynein motor where the P-loop has been lost in evolution but the general structure of a potential ATP binding site appears to be retained.
Wikipedia: Dyneins are a family of cytoskeletal motor proteins that move along microtubules in cells. They convert the chemical energy stored in ATP to mechanical work. Dynein transports various cellular cargos, provides forces and displacements important in mitosis, and drives the beat of eukaryotic cilia and flagella. All of these functions rely on dynein's ability to move towards the minus-end of the microtubules, known as retrograde transport; thus, they are called "minus-end directed motors". In contrast, most kinesin motor proteins move toward the microtubules' plus-end, in what is called anterograde transport.
Pfam PF14265: Capsid assembly scaffolding protein Gp46 (family)
This entry includes the capsid assembly scaffolding protein Gp46 from Staphylococcus phage 80alpha, which is involved in icosaedric procapsid assembly. It coassembles with capsid proteins to form the procapsid. The scaffolding protein is found within the capsid as a series of concentric shells. During DNA packaging, the scaffolding protein molecules are released from the procapsid.
Pfam PF07279: Protein of unknown function (DUF1442) (family)
This family consists of several hypothetical Arabidopsis thaliana proteins of around 225 residues in length. The function of this family is unknown.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF11590: DNA polymerase catalytic subunit Pol (family)
This family of proteins represents the catalytic subunit, Pol, of the Herpes simplex virus DNA polymerase. Pol binds UL42, making up the DNA polymerase. UL42 is a processivity subunit which binds to the C-terminal of Pol in a similar way that the cell cycle regulator p21 binds to PCNA.
Pfam PF05268: Phage tail fibre adhesin Gp38 (domain)
This family contains several Gp38 proteins from T-even-like phages. Gp38,  together with a second phage protein, gp57, catalyses the organisation of  gp37 but is absent from the phage particle. Gp37 is responsible for  receptor recognition.
Pfam PF02552: CO dehydrogenase beta subunit/acetyl-CoA synthase epsilon subunit (family)
This family consists of Carbon monoxide dehydrogenase I/II beta subunit  [ec:1.2.99.2] and acetyl-CoA synthase epsilon subunit. Carbon monoxide beta subunit catalyses the reaction: CO + H2O + acceptor  CO2 + reduced  acceptor.
Pfam PF02926: THUMP domain (domain)
The THUMP domain is named after after thiouridine synthases, methylases and PSUSs. The THUMP domain consists of about 110 amino acid residues. This domain is found in many tRNA modification enzymes classified into five types, namely 4-thiouridine synthetase, deaminase, methyltransferase, a partner protein of acetyltransferase and pseudouridine synthase. The structure of ThiI reveals that the THUMP has a fold unlike that of previously characterised RNA-binding domains and was first predicted to function by delivering a variety of RNA modification enzymes to their targets. Studies performed in tRNA 4-thiouridine synthetase, tRNA methyltransferases and tRNA deaminase suggest that the THUMP domain captures the 3'-end of RNA but in some cases this is not applicable due to the modification patterns observed in tRNA. Several THUMP-related proteins are also involved in other RNAs modifications, such as rRNA modification.
Pfam PF11230: Glycyl radical enzyme YjjI-like (family)
Members in this family are homologues to enzymes known to undergo activation by a radical SAM protein to create an active site glycyl radical. This family appears to be activated by the YjjW radical SAM protein, usually encoded by an adjacent gene.
Pfam PF00341: PDGF/VEGF domain (domain)
Platelet-derived growth factor (PDGF)  is a potent mitogen for cells of mesenchymal origin, including smooth muscle cells and glial cells. In both mouse and human, the PDGF signalling network consists of four ligands, PDGFA-D, and two receptors, PDGFRalpha and PDGFRbeta. All PDGFs function as secreted, disulphide-linked homodimers, but only PDGFA and B can form functional heterodimers. PDGFRs also function as homo- and heterodimers. All known PDGFs have characteristic 'PDGF domains', which include eight conserved cysteines that are involved in inter- and intramolecular bonds. Alternate splicing of the A chain transcript can give rise to two different forms that differ only in their C-terminal extremity. The transforming protein of Woolly monkey sarcoma virus (WMSV) (Simian sarcoma virus), encoded by the v-sis oncogene, is derived from the B chain of PDGF.

PDGFs are mitogenic during early developmental stages, driving the proliferation of undifferentiated mesenchyme and some progenitor populations. During later maturation stages, PDGF signalling has been implicated in tissue remodelling and cellular differentiation, and in inductive events involved in patterning and morphogenesis. In addition to driving mesenchymal proliferation, PDGFs have been shown to direct the migration, differentiation and function of a variety of specialised mesenchymal and migratory cell types, both during development and in the adult animal .

Other growth factors in this family include vascular endothelial growth factors B and C (VEGF-B, VEGF-C)  which are active in angiogenesis and endothelial cell growth, and placenta growth factor (PlGF) which is also active in angiogenesis . VEGF is a potent mitogen in embryonic and somatic angiogenesis with a unique specificity for vascular endothelial cells. VEGF forms homodimers and exists in 4 different isoforms. Overall, the VEGF monomer resembles that of PDGF, but its N-terminal segment is helical rather than extended.

PDGF is structurally related to a number of other growth factors which also form disulphide-linked homo- or heterodimers. A cysteine knot motif is a common feature of this domain .
Wikipedia: Platelet-derived growth factor (PDGF) is one among numerous growth factors that regulate cell growth and division. In particular, PDGF plays a significant role in blood vessel formation, the growth of blood vessels from already-existing blood vessel tissue, mitogenesis, i.e. proliferation, of mesenchymal cells such as fibroblasts, osteoblasts, tenocytes, vascular smooth muscle cells and mesenchymal stem cells as well as chemotaxis, the directed migration, of mesenchymal cells. Platelet-derived growth factor is a dimeric glycoprotein that can be composed of two A subunits (PDGF-AA), two B subunits (PDGF-BB), or one of each (PDGF-AB).
Pfam PF13401: AAA domain (domain)
This entry represents a number of closely related AAA+ ATPase domains from proteins involved in diverse processes such as DNA replication, DNA transposition and mRNA splicing. Amongst the proteins containing this domain are Origin recognition complex (ORC) subunits , Transposon Tn7 transposition protein TnsC , cell division control proteins  and pre-mRNA-splicing factor ATP-dependent RNA helicases .
Wikipedia: AAA proteins are a large group of protein family sharing a common conserved module of approximately 230 amino acid residues. This is a large, functionally diverse protein family belonging to the AAA+ protein superfamily of ring-shaped P-loop NTPases, which exert their activity through the energy-dependent remodeling or translocation of macromolecules.
Pfam PF19100: Family of unknown function (DUF5787) (family)
Family of unknown function predominantly found in Halobacteria.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF15283: Domain of unknown function (DUF4595) with porin-like fold (domain)
Large family of predicted secreted proteins mostly from  CFG group, but also from Burkholderia, Pseudomonas and Streptomyces. Function of these proteins is not known. A 3D structure of a representative of this family from  Bacteroides uniformis was solved by JCSG and deposited to PDB as 4ghb. There is some overlap with RHS-repeat (PF05593) family despite lack of obvious repeats in the structure.
Pfam PF08795: Putative papain-like cysteine peptidase (DUF1796) (domain)
The proteins in this entry are uncharacterised; but are related to papain-like cysteine peptidases.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF20489: Birnavirus RNA dependent RNA polymerase (VP1), C-terminal (domain)
Birnaviruses are dsRNA viruses. This entry corresponds to the C-terminal domain of RNA dependent RNA polymerase also known as VP1. All of the birnavirus VP1 proteins contain conserved RdRp motifs that reside in the catalytic "palm" domain of all classes of polymerases. However, the birnavirus RdRps lack the highly conserved Gly-Asp-Asp (GDD) sequence, a component of the proposed catalytic site of this enzyme family that exists in the conserved motif VI of the palm domain of other RdRps. This RdRp has the five essential RNA polymerase motifs in a permuted order of C-A-B-D-E to form a conserved catalytic active site. This domain is mostly alpha-helical that runs across the canyon in the front of the palm, and wraps around the fingers subdomain, which may function to prevent back-primed RNA synthesis during protein priming.
Wikipedia: Birnaviridae is a family of double-stranded RNA viruses. Salmonid fish, birds and insects serve as natural hosts. There are currently 11 species in this family, divided among seven genera. Diseases associated with this family include infectious pancreatic necrosis in salmonid fish, which causes significant losses to the aquaculture industry, with chronic infection in adult salmonid fish and acute viral disease in young salmonid fish.
Pfam PF08667: BetR domain (domain)
This family includes an N-terminal helix-turn-helix domain.
Pfam PF22769: dCTP deaminase-like (domain)
This entry represents a dCTP deaminase (DCD) domain found in archaea and bacteria. Methanococcus jannaschii, has a bifunctional enzyme DCD-DUT, that harbors both dCTP deaminase and dUTP pyrophosphatase activities.
Pfam PF01176: Translation initiation factor 1A / IF-1 (domain)
This family includes both the eukaryotic translation factor eIF-1A and the bacterial translation initiation factor IF-1.
Pfam PF06182: ABC-2 family transporter protein (family)
This family acts as the transmembrane domain (TMD) of ABC transporters. The family includes proteins responsible for the transport of herbicides.
Wikipedia: The ABC transporters, ATP synthase (ATP)-binding cassette transporters are a transport system superfamily that is one of the largest and possibly one of the oldest gene families. It is represented in all extant phyla, from prokaryotes to humans. ABC transporters belong to translocases.
Pfam PF22228: CofB beta-repeat domain (repeat)
CofB is a minor pilin involved in type IV pili assembly. It consists of a pilin domain at the N-terminal, followed by a beta-repeat hinge-like domain and a C-terminal beta-sheet-rich lectin domain. This entry represents the central beta-repeat domain which has two three-stranded anti-parallel beta-sheets.
Pfam PF12495: Vegetative insecticide protein 3A N terminal (family)
This family of proteins is found in bacteria. Proteins in this family are typically between 170 and 789 amino acids in length. The family is found in association with [pfam:PF02018]. Vip3A represents a novel class of proteins insecticidal to lepidopteran insect larvae.
Pfam PF09649: Histone chaperone domain CHZ (domain)
This domain is highly conserved from yeasts to humans and is part of the chaperone protein HIRIP3 in vertebrates which interacts with the H3.3 chaperone HIRA, implicated in histone replacement during transcription. N- and C- termini of Chz family members are relatively divergent but do contain similar acidic stretches rich in Glu/Asp residues, characteristic of all histone chaperones.
Pfam PF20001: Family of unknown function (DUF6428) (family)
This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 155 and 220 amino acids in length. There are two conserved sequence motif, DCGG and QLW, and conserved cysteine residues at the C-terminal.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF18565: Glycoside hydrolase family 2 C-terminal domain 5 (domain)
Domain 5 is found in dimeric beta-D-galactosidase from Paracoccus sp. 32d, which contributes to stabilization of the functional dimer. It is suggested that the location of this domain 5, may be one of the factors responsible for the creation of a functional dimer and cold-adaptation of this enzyme.
Pfam PF08096: Bombolitin family (family)
This family consists of the bombolitin peptides that  are found in the venom of the bumblebee Megabombus  pennsylvanicus. Bombolitins are structurally and  functionally very similar. They lyse erythrocytes and  liposomes, release histamine from rat peritoneal mast  cells, and stimulate phospholipase A2 from different  sources.
Pfam PF02571: Precorrin-6x reductase CbiJ/CobK (family)
This family consists of Precorrin-6x reductase [ec:1.3.1.54]. This enzyme catalyses the reaction: precorrin-6Y + NADP(+)   precorrin-6X + NADPH.  CbiJ and CobK both catalyse the reduction of macocycle in the colbalmin biosynthesis pathway.
Wikipedia: Cobalamin biosynthesis is the process by which bacteria and archea make cobalamin, vitamin B12. Many steps are involved in converting aminolevulinic acid via uroporphyrinogen III and adenosylcobyric acid to the final forms in which it is used by enzymes in both the producing organisms and other species, including humans who acquire it through their diet.
Pfam PF13811: Domain of unknown function (DUF4186) (family)
This protein family is functionally uncharacterised.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF06442: R67 dihydrofolate reductase (domain)
R67 dihydrofolate reductase is a plasmid encoded enzyme that provides resistance to the antibacterial  drug trimethoprim. The R67 dihydrofolate reductase does not share significant similarity to the chromosomal encoded dihydrofolate reductase.
Wikipedia: Dihydrofolate reductase, or DHFR, is an enzyme that reduces dihydrofolic acid to tetrahydrofolic acid, using NADPH as an electron donor, which can be converted to the kinds of tetrahydrofolate cofactors used in one-carbon transfer chemistry. In humans, the DHFR enzyme is encoded by the DHFR gene. It is found in the q14.1 region of chromosome 5.
Pfam PF09716: Malarial early transcribed membrane protein (ETRAMP) (family)
These sequences represent a family of proteins from the malaria parasite Plasmodium falciparum, several of which have been shown to be expressed specifically in the ring stage as well as the rodent parasite Plasmodium yoelii. A homologue from Plasmodium chabaudi was localised to the parasitophorous vacuole membrane. Members have an initial hydrophobic, Phe/Tyr-rich, stretch long enough to span the membrane, a highly charged region rich in Lys, a second putative transmembrane region and a second highly charged, low complexity sequence region. Some members have up to 100 residues of additional C-terminal sequence. These genes have been shown to be found in the sub-telomeric regions of both Plasmodium falciparum and P. yoelii chromosomes.
Pfam PF12409: P5-type ATPase cation transporter (family)
This domain family is found in eukaryotes, and is typically between 110 and 126 amino acids in length. The family is found in association with [pfam:PF00122], [pfam:PF00702]. P-type ATPases comprise a large superfamily of proteins, present in both prokaryotes and eukaryotes, that transport inorganic cations and other substrates across cell membranes.
Pfam PF06215: Infectious salmon anaemia virus haemagglutinin (family)
This family consists of several infectious salmon anaemia virus haemagglutinin proteins. Infectious salmon anaemia virus (ISAV), an orthomyxovirus-like virus, is an important fish pathogen in marine aquaculture.
Pfam PF11005: Protein of unknown function (DUF2844) (family)
This bacterial family of proteins has no known function.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF00748: Calpain inhibitor (family)
This region is found multiple times in calpain inhibitor proteins.
Pfam PF15893: Domain of unknown function (DUF4739) (family)
This presumed domain is functionally uncharacterised. This domain family is found in eukaryotes, and is typically between 138 and 167 amino acids in length.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF21759: AIR2-like, CCHC-type 1 zinc finger 4 (conserved_site)
This motif is found in Protein AIR2 from Saccharomyces cerevisiae, also known as Arginine methyltransferase-interacting RING finger protein 2, and similar proteins from yeasts. AIR2 is an RNA-binding subunit of the TRAMP complex which has a poly(A) RNA polymerase activity and is involved in a post-transcriptional quality control mechanism limiting inappropriate expression of genetic information. This protein contain five tandemly arranged zinc-knuckle (ZnK) motifs of the CCHC-type (CX2CX4HX4C), which been shown to bind nucleic acids and proteins in unrelated proteins. This entry represents the fourth CCHC-type 1 zinc finger  (ZnK4) of AIR2, which is important for TRAMP functions and integrity.
Pfam PF18007: Rv3651-like, N-terminal (domain)
This domain is found in Rv3651 from Mycobacterium tuberculosis ([swissprot:I6YCP0]) and similar proteins from Actinobacteria. Rv3651 adopts a three-domain configuration. This entry represents the N-terminal domain, a GAF domain that shows a central antiparallel beta-sheet of six beta-strands.
Pfam PF05217: Stabilizer of axonemal microtubules 1/2 (family)
Neurons contain abundant subsets of highly stable microtubules that resist de-polymerising conditions such as exposure to the cold. Stable  microtubules are thought to be essential for neuronal development, maintenance, and function. This entry includes Stabilizer of axonemal microtubules 1/2 (SAXO1/2), which may play a role in the regulation of cilium length. Human SAXO1 binds specifically to centriole and cilium microtubules. It stabilizes microtubules at low temperature.