SII-SWORD/CoKE huggingface dataset:
Pfam PF10702: Protein of unknown function (DUF2507) (family)
This family is conserved in Firmicutes. The function is not known.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF05093: Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis (domain)
Anamorsin, subsequently named CIAPIN1 for cytokine-induced anti-apoptosis inhibitor 1, in humans is the homologue of yeast Dre2, a conserved soluble eukaryotic Fe-S cluster protein, that functions in cytosolic Fe-S protein biogenesis. It is found in both the cytoplasm and in the mitochondrial intermembrane space (IMS).  CIAPIN1 is found to be up-regulated in hepatocellular cancer, is considered to be a downstream effector of the receptor tyrosine kinase-Ras signalling pathway, and is essential in mouse definitive haematopoiesis. Dre2 has been found to interact with the yeast reductase Tah18, forming a tight cytosolic complex implicated in the response to high levels of oxidative stress. These proteins consist of two domains, the N-terminal well-folded one, with a S-adenosylmethionine methyltransferase-like fold and the C-terminal more flexible domain, represented in this entry, which contains two highly conserved cysteine rich motifs that bind Fe-S clusters.
Pfam PF10146: Zinc finger-containing protein (family)
This is a family of proteins which appears to have a highly conserved zinc finger domain at the C terminal end, described as -C-X2-CH-X3-H-X5-C-X2-C-. The structure is predicted to contain a coiled coil. Members are annotated as being tumour-associated antigen HCA127 in humans but this could not confirmed.
Pfam PF12052: Voltage gated calcium channel subunit beta domain 4Aa N terminal (domain)
The beta subunit of voltage gated calcium channels is coded for by four genes 1-4. Gene 4 can produce two types of beta4A domain (beta4Aa and beta4Ab) according to how the gene splicing is carried out. This family is part of the beta4Aa N terminal domain. It is made up of an alpha helix and a beta strand. It is thought to regulate the channel properties through protein-protein interactions with non Ca channel proteins.
Pfam PF10654: Protein of unknown function (DUF2481) (family)
This is a hypothetical protein family homologous to Lmo2305 in Bacteriophage A118 systems.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF01690: Potato leaf roll virus readthrough protein (family)
This family consists mainly of the potato leaf roll virus readthrough protein. This is generated via a readthrough  of open reading frame 3 a coat protein allowing transcription of open reading frame 5 to give an extended coat protein  with a large c-terminal addition or read through domain. The readthrough protein is thought to play a role in the circulative aphid transmission of potato leaf roll virus. Also in the family is open reading frame 6 from beet western yellows virus and potato leaf roll virus both luteovirus and an unknown protein from cucurbit aphid-borne yellows virus a closterovirus.
Pfam PF07208: Protein of unknown function (DUF1414) (family)
This family consists of several hypothetical bacterial proteins of around 70 residues in length. Members of this family are often referred to as YejL. The function of this family is unknown.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF15464: Domain of unknown function (DUF4633) (family)
This family of proteins is found in eukaryotes. Proteins in this family are typically between 94 and 123 amino acids in length.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF25019: R13L1/DRL21 LRRs (repeat)
This entry represents Leucine-rich repeats (LRRs) found in R13L1, DRL21 from Arabidopsis thaliana and related plant proteins. R13L1 and DRL21 are likely disease resistance proteins. DRL21 has adenylate cyclase activity.
Pfam PF03364: Polyketide cyclase / dehydrase and lipid transport (family)
This family contains polyketide cylcases/dehydrases which are enzymes involved in polyketide synthesis. The family also includes proteins which are involved in the binding/transport of lipids.
Pfam PF02261: Aspartate decarboxylase (domain)
Decarboxylation of aspartate is the major route of beta-alanine production in bacteria, and is catalysed by the enzyme aspartate decarboxylase [ec:4.1.1.11] which requires a pyruvoyl group for its activity. It is synthesised initially as a proenzyme which is then proteolytically cleaved to an alpha (C-terminal) and beta (N-terminal) subunit and a pyruvoyl group. This family contains both chains of aspartate decarboxylase.
Pfam PF23049: Domain of unknown function (DUF7039) (domain)
This entry represents a domain found in a family of uncharacterised proteins in nematodes.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF04938: Survival motor neuron (SMN) interacting protein 1 (SIP1) (family)
Survival motor neuron (SMN) interacting protein 1 (SIP1) interacts with SMN protein and plays a crucial role in the biogenesis of spliceosomes. There is evidence that the protein is linked to spinal muscular atrophy (SMA) and amyotrophic lateral sclerosis(ALS) in humans.
Pfam PF19644: Family of unknown function (DUF6147) (family)
This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 155 and 173 amino acids in length.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF13670: Peptidase propeptide and YPEB domain (domain)
This region is likely to have a protease inhibitory function (personal obs:C Yeats).  The name is derived from Peptidase & Bacillus subtilis YPEB.
Pfam PF11415: Antifungal peptide termicin (domain)
Termicin is a cysteine-rich antifungal peptide which exhibits antibacterial activity. A cysteine stabilised alpha beta motif is formed due to an alpha-helical segment and a two-stranded antiparallel beta-sheet.
Pfam PF18860: AbiJ N-terminal domain 3 (domain)
Alpha + beta domain. Found fused to AbiJ-like HEPN. Fused to other domains presumably involved in defense.
Pfam PF14195: Domain of unknown function (DUF4316) (family)
This domain is functionally uncharacterised. This domain is found in bacteria, and is typically between 56 and 95 amino acids in length.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF09051: Stannin cytoplasmic (domain)
Members of this family consist of a distorted cytoplasmic helix that is partially absorbed into the plane of the lipid bilayer with a tilt angle of approximately 80 degrees from the membrane normal. They interact with the surface of the lipid bilayer, and contribute to the initiation of the apoptotic cascade on binding of the unstructured linker domain to dimethyltin.
Pfam PF25049: 3'-5' exoribonuclease HELZ2, OB-fold domain (domain)
This domain is found in human 3'-5' exoribonuclease HELZ2 and similar animal proteins. HELZ2 can degrade highly structured RNAs through its concerted ATP-dependent RNA helicase and 3' to 5' exoribonuclease activities.
Pfam PF00780: CNH domain (repeat)
Domain found in NIK1-like kinase, mouse citron and yeast ROM1, ROM2. Unpublished observations.
Pfam PF24539: Domain of unknown function (DUF7600) (domain)
This domain of unknown function is found once or twice in a group of fungal uncharacterised proteins. It is predicted to adopt a mainly beta configuration.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF18205: VPDSG-CTERM motif (conserved_site)
The PEP-CTERM/exosortase system has been previously identified through in silico analysis. This entry describes a PEP-CTERM-like variant C-terminal protein sorting signal, as found at the C terminus of twenty otherwise unrelated proteins in Verrucomicrobiae bacterium DG1235. The variant motif, VPDSG, seems an intermediate between the VPEP motif of typical exosortase systems and the classical LPXTG of sortase in Gram-positive bacteria.
Pfam PF01344: Kelch motif (repeat)
The kelch motif was initially discovered in Kelch ([swissprot:Q04652]). In this protein there are six copies of the motif.  It has been shown that [swissprot:Q04652] is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet.  Several of these sheets associate to form a beta propeller structure as found in [pfam:PF00064], [pfam:PF00400] and [pfam:PF00415].
Wikipedia: The Kelch motif is a region of protein sequence found widely in proteins from bacteria and eukaryotes. This sequence motif is composed of about 50 amino acid residues which form a structure of a four stranded beta-sheet "blade". This sequence motif is found in between five and eight tandem copies per protein which fold together to form a larger circular solenoid structure called a beta-propeller domain.
Pfam PF22465: Spike protein P1, second jelly-roll domain (domain)
This entry represents the second jelly-roll domain of Spike protein P1 from Pseudoalteromonas phage PM2.
Pfam PF03034: Phosphatidyl serine synthase (family)
Phosphatidyl serine synthase is also known as serine exchange enzyme.  This family represents eukaryotic PSS I and II which are membrane bound proteins which catalyses the replacement of the head group of a phospholipid (phosphotidylcholine or phosphotidylethanolamine) by L-serine.
Pfam PF13876: Phage protein (N4 Gp49/phage Sf6 gene 66) family (family)
This family of phage proteins is functionally uncharacterised. The family includes bacteriophage Sf6 gene 66 [swissprot:Q716B1] as well as phage N4 GP49 protein [swissprot:A0MZD7]. Proteins in this family are typically between 87 and 154 amino acids in length. There is a conserved NGF sequence motif.
Pfam PF13390: Protein of unknown function (DUF4108) (family)
This family of putative proteins are found in Trichomonas vaginalis in large numbers.      The function of this protein is unknown.
Pfam PF15805: Acidic C-terminal region of sodium channel modifier 1 SCNM1 (family)
SCNM1_acidic is the C-terminal acidic region of eukaryotic sodium channel modifier protein 1. Deletion of this region affects the splicing and normal activity of the sodium channel Nav1.6 from gene Scn8a. SCNM1 sits within the U1C subfamily of RNA binding proteins that is commonly found in RNA-processing proteins, suggesting that SCNM1 is involved in splicing activities. SCNM1 and LUC7L2 associate with the mammalian spliceosomal subunit U1 snRNP.
Pfam PF17822: Armadillo-like helical domain-containing protein 2 (family)
The function of this Armadillo-like helical domain-containing protein is not known.
Pfam PF12438: Protein of unknown function (DUF3679) (family)
This domain family is found in bacteria, and is approximately 60 amino acids in length.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF00874: PRD domain (domain)
The PRD domain (for PTS Regulation Domain), is the phosphorylatable regulatory domain found in bacterial transcriptional antiterminator such as BglG, SacY and LicT, as well as in activators such as MtlR and LevR. The PRD is phosphorylated on one or two conserved histidine residues. PRD-containing proteins are involved in the regulation of catabolic operons in Gram+ and Gram- bacteria and are often characterised by a short N-terminal effector domain that binds to either RNA (CAT-RBD for antiterminators [pfam:PF03123]) or DNA (for activators), and a duplicated PRD module which is phosphorylated by the sugar phosphotransferase system (PTS) in response to the availability of carbon source. The phosphorylations modify the conformation and stability of the dimeric proteins and thereby the RNA- or DNA-binding activity of the effector domain. The structure of the LicT PRD domains has been solved in both the active (pdb:1h99,) and inactive state (pdb:1tlv), revealing massive structural rearrangements upon activation.
Pfam PF22133: Botulinum neurotoxin, helical domain (domain)
This entry represents an elongated helical domain present in Clostridium neurotoxins. The Clostridium neurotoxin family is composed of tetanus neurotoxin and seven serotypes of botulinum neurotoxin.
Pfam PF07428: 15-O-acetyltransferase Tri3 (family)
This family represents a conserved region approximately 400 residues long within 15-O-acetyltransferase (Tri3), which seems to be restricted to ascomycete fungi. In Fusarium sporotrichioides, this is required for acetylation of the C-15 hydroxyl group of trichothecenes in the biosynthesis of T-2 toxin.
Pfam PF16325: Peptidase family U32 C-terminal domain (domain)
This domain is found at the C-terminus of many members of Peptidase family U32 ([pfam:PF01136]).
Pfam PF23000: Chitin synthase N-terminal putative transporter domain (domain)
This entry represents an N-terminal integral membrane domain found in chitin synthases. The Chitin Synthase Class IV family is involved in the synthesis of chitin, which is a key structural component in various biological structures. Members of this family are essential for specific developmental processes in organisms. For instance, CHS1 is crucial for the embryonic synthesis of chitin that forms part of the eggshell, indicating a role in protecting and structuring the embryo. On the other hand, CHS2 appears to be involved in the synthesis of chitin within the pharynx during larval development, suggesting a function in the morphogenesis and maintenance of larval structures. The activities of the Chitin Synthase Class IV family members are indicative of their importance in the developmental stages of organisms that produce chitin as a component of their extracellular matrix or exoskeleton.
Pfam PF03562: MltA specific insert domain (domain)
This beta barrel domain is found inserted in the MltA a murein degrading transglycosylase enzyme. This domain may be involved in peptidoglycan binding.
Pfam PF01468: GA module (domain)
The GA (protein G-related Albumin-binding) module is composed of three alpha helices. This module is found in a range of bacterial cell surface proteins. The GA module from [swissprot:Q51911] shows a strong affinity for albumin.
Wikipedia: In molecular biology, the GA module, or protein G-related albumin-binding module, is a protein domain which occurs on the surface of numerous Gram-positive bacterial pathogens. Protein G of group C and G Streptococci interacts with the constant region of IgG and with human serum albumin. The GA module is composed of a left-handed three-helix bundle and is found in a range of bacterial cell surface proteins. GA modules may promote bacterial growth and virulence in mammalian hosts by scavenging albumin-bound nutrients and camouflaging the bacteria. Variations in sequence give rise to differences in structure and function between GA modules in different proteins, which could alter pathogenesis and host specificity due to their varied affinities for different species of albumin. Proteins containing a GA module include PAB from Peptostreptococcus magnus.
Pfam PF18457: Up-Regulated in long-lived daf-2 (domain)
This entry includes C. elegans PUD-1 and PUD-2, two proteins up-regulated in daf-2(loss-of-function) (PUD), are homologous 17-kD proteins with similar beta-sandwich folds that further associate with each other into a V-shaped heterodimer.
Pfam PF01300: Telomere recombination (family)
This domain has been shown to bind preferentially to dsRNA. The domain is found in SUA5 [swissprot:P32579] as well as HypF and YrdC [swissprot:P45748]. It has also been shown to be required for telomere recombniation in yeast.
Pfam PF18607: ParA helix turn helix domain (domain)
The accurate segregation of DNA is essential for the faithful inheritance of genetic information. Segregation of the prototypical P1 plasmid par system requires two proteins, ParA and ParB, and a centromere. When bound to ATP, ParA mediates segregation by interacting with centromere-bound ParB, but when bound to ADP, ParA fulfills a different function: DNA-binding transcription autoregulation. ParA consists of an elongated N-terminal alpha-helix which mediates dimerization, a winged-HTH and a Walker-box containing C-domain. This entry describes the N-terminal alpha helix domain combined with the winged HTH region.
Pfam PF19180: Family of unknown function (DUF5862) (family)
This is a family of uncharacterised proteins of unknown function predominantly found in Ascoviridae. This family also includes uncharacterised proteins found in Bacteria.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF15397: Domain of unknown function (DUF4618) (family)
This family of proteins is found in eukaryotes. Proteins in this family are typically between 238 and 363 amino acids in length. There are two conserved sequence motifs: EYP and KCTPD.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF04451: Large eukaryotic DNA virus major capsid protein (domain)
This family includes the major capsid protein of iridoviruses, chlorella virus and Spodoptera ascovirus, which are all dsDNA viruses with no RNA stage. This is the most abundant structural protein and can account for up to 45% of virion protein.  In Chlorella virus PBCV-1 the major capsid protein is a glycoprotein. The four families of large eukaryotic DNA viruses, Poxviridae, Asfarviridae, Iridoviridae, and Phycodnaviridae, are referred to collectively as nucleocytoplasmic large DNA viruses or NCLDV. The virions of different NCLDV have dramatically different structures. The major capsid proteins of iridoviruses and phycodnaviruses, both of which have icosahedral capsids surrounding an inner lipid membrane, showed a high level of sequence conservation. A more limited, but statistically significant sequence similarity was observed between these proteins and the major capsid protein (p72) of ASFV, which also has an icosahedral capsid. It was surprising, however, to find that all of these proteins shared a conserved domain with the poxvirus protein D13L, which is an integral virion component thought to form a scaffold for the formation of viral crescents and immature virion.
Pfam PF24483: Domain of unknown function (DUF7582) (domain)
This domain is found in uncharacterised sequences from fungi. It may adopt a nucleotidyl transferase-like fold.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF08290: Hepatitis core protein, putative zinc finger (domain)
This short region is found at the N-terminus of some hepatitis core proteins.      Its conservation of four cys and his suggests a zinc binding domain.
Pfam PF13618: Gluconate 2-dehydrogenase subunit 3 (family)
This family corresponds to subunit 3 of the Gluconate 2-dehydrogenase enzyme that catalyses the conversion of gluconate to 2-dehydro-D-gluconate [ec:1.1.99.3].
Pfam PF10269: Transmembrane Fragile-X-F protein (family)
This is a family of conserved transmembrane proteins that appear in humans to be expressed from a region upstream of the FragileXF site and to be intimately linked with the Fragile-X syndrome. Absence of TMEM185A does not necessarily lead to developmental delay, but might in combination with other, yet unknown, factors. Otherwise, the lack of the TMEM185A protein is either disposable (redundant) or its function can be complemented by the highly similar chromosome 2 retro-pseudogene product, TMEM185B.
Pfam PF23053: N4BP1, UBA-like domain (domain)
This domain is found in the human NEDD4-binding protein 1 (N4BP1) and related proteins. It has a significant sequence and structural similarity to UBA domains. This domain is predicted to adopt a globular structure consisting of a three helical bundle.