SII-SWORD/CoKE huggingface dataset:
Pfam PF24640: Domain of unknown function (DUF7635) (repeat)
This is a presumed domain found in uncharacterised sequences from plasmodium falciparum (SwissProt:Q8IBR8) and similar sequences from Apicomplexa. It may adopt a beta-propeller-like fold, which, from structure predictions, it seems incomplete.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF00759: Glycosyl hydrolase family 9 (repeat)
O-Glycosyl hydrolases (3.2.1.) are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycosyl hydrolases, based on sequence similarity, has led to the definition of 85 different families . This classification is available on the CAZy (CArbohydrate-Active EnZymes) website.
Glycoside hydrolase family 9 GH9 comprises enzymes with several known activities; endoglucanase (3.2.1.4); cellobiohydrolase (3.2.1.91). These enzymes were formerly known as cellulase family E.
Wikipedia: In molecular biology, glycoside hydrolase family 9 is a family of glycoside hydrolases.
Pfam PF12625: Arabinose-binding domain of AraC transcription regulator, N-term (domain)
AraC is a bacterial transcriptional regulatory protein with a DNA-binding domain at the C-terminus, HTH_AraC, [pfam:PF00165], and this dimerisation domain which harbours the arabinose-binding pocket at the N-terminus. AraC positively and negatively regulates expression of the proteins required for the uptake and catabolism of the sugar L-arabinose 1,2,3].
Pfam PF00009: Elongation factor Tu GTP binding domain (domain)
This domain contains a P-loop motif, also found in several other families such as [pfam:PF00071], [pfam:PF00025] and [pfam:PF00063]. Elongation factor Tu consists of three structural domains, this plus two C-terminal beta barrel domains.
Wikipedia: EF-Tu is a prokaryotic elongation factor responsible for catalyzing the binding of an aminoacyl-tRNA (aa-tRNA) to the ribosome. It is a G-protein, and facilitates the selection and binding of an aa-tRNA to the A-site of the ribosome. As a reflection of its crucial role in translation, EF-Tu is one of the most abundant and highly conserved proteins in prokaryotes. It is found in eukaryotic mitochondria as TUFM.
Pfam PF04465: Protein of unknown function (DUF499) (family)
Family of uncharacterised hypothetical prokaryotic proteins.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF07811: TadE-like protein (family)
The members of this family are similar to a region of  the protein product of the bacterial tadE locus ([swissprot:Q9S4A6]). In various bacterial species, the tad locus is closely  linked to flp-like genes, which encode proteins required  for the production of pili involved in adherence to  surfaces. It is thought that the tad loci encode  proteins that act to assemble or export an Flp pilus in  various bacteria. All tad loci but TadA have putative transmembrane regions, and in fact the region in  question is this family has a high proportion of hydrophobic  amino acid residues.
Pfam PF00664: ABC transporter transmembrane region (family)
This family represents a unit of six transmembrane helices. Many members of the ABC transporter family ([pfam:PF00005]) have two such regions.
Wikipedia: ABC transporter transmembrane domain is the main transmembrane structural unit of ATP-binding cassette transporter proteins, consisting of six alpha helixes that traverse the plasma membrane. Many members of the ABC transporter family have two such regions.
Pfam PF18775: APOBEC4 (family)
A member of the AID/APOBEC family of cytosine deaminases. The biological function of APOBEC4 is poorly understood. However, it is widely conserved across vertebrates.
Pfam PF14550: Putative phage serine protease XkdF (family)
This domain is largely found on phage proteins.  In a number of cases the domain is associated with a SAM-dependent methyltransferase. Members are serine peptidases.
Pfam PF13493: Domain of unknown function (DUF4118) (domain)
This domain is found in a wide variety of bacterial signalling proteins. It is likely to be a transmembrane domain involved in ligand sensing.
Pfam PF13631: Cytochrome b(N-terminal)/b6/petB (domain)
In the mitochondrion of eukaryotes and in aerobic prokaryotes, cytochrome b is a component of respiratory chain complex III (1.10.2.2) - also known as the bc1 complex or ubiquinol-cytochrome c reductase. In plant chloroplasts and cyanobacteria, there is a analogous protein, cytochrome b6, a component of the plastoquinone-plastocyanin reductase (1.10.99.1), also known as the b6f complex.

Cytochrome b/b6  is an integral membrane protein of approximately 400 amino acid residues that probably has 8 transmembrane segments. In plants and cyanobacteria, cytochrome b6 consists of two subunits encoded by the petB and petD genes. The sequence of petB is colinear with the N-terminal part of mitochondrial cytochrome b, while petD corresponds to the C-terminal part. Cytochrome b/b6 non-covalently binds two haem groups, known as b562 and b566. Four conserved histidine residues are postulated to be the ligands of the iron atoms of these two haem groups.

Apart from regions around some of the histidine haem ligands, there are a few conserved regions in the sequence of b/b6. The best conserved of these regions includes an invariant P-E-W triplet which lies in the loop that separates the fifth and sixth transmembrane segments. It seems to be important for electron transfer at the ubiquinone redox site - called Qz or Qo (where o stands for outside) - located on the outer side of the membrane. This entry represents the N-terminal region of these proteins.
Wikipedia: Cytochrome b is a protein found in the membranes of aerobic cells. In eukaryotic mitochondria and in aerobic prokaryotes, cytochrome b is a component of respiratory chain complex III — also known as the bc1 complex or ubiquinol-cytochrome c reductase. In plant chloroplasts and cyanobacteria, there is a homologous protein, cytochrome b6, a component of the plastoquinone-plastocyanin reductase, also known as the b6f complex. These complexes are involved in electron transport, the pumping of protons to create a proton-motive force (PMF). This proton gradient is used for the generation of ATP. These complexes play a vital role in cells.
Pfam PF18393: MotY N-terminal domain (domain)
The bacterial flagellar motor is a rotary motor complex composed of various proteins. MotX and MotY are essential for the Na+-driven flagellar motor motility of Vibrio, Shewanella and Aeromonas species. MotY is main component for T-ring formation and absence of MotY completely disrupt the T-ring formation. This is the N-terminal domain of MotY which is shown to be essential for motility and responsible for the interaction with both MotX and the basal body. Functional analysis suggests that MotY-N connects the basal body to MotX and that the PomA/PomB complex associates with MotX to form the functional stator complex around the rotor. MotY-N alone does not associate strongly with the basal body, but the partial T-ring structure made of the MotY-N/MotX complex is sufficient to allow at least a few PomA/PomB stator complexes to be incorporated into the motor.
Pfam PF09367: CpeS-like protein (domain)
This family, that includes CpeS proteins, is functionally uncharacterised.
Pfam PF06773: Bim protein N-terminus (family)
This family represents the N-terminal region of several mammal specific Bim proteins. The Bim protein is one of the BH3-only proteins, members of the Bcl-2 family that have only one of the Bcl-2 homology regions, BH3. BH3-only proteins are essential initiators of apoptotic cell death.
Pfam PF01457: Leishmanolysin (family)
This group of metallopeptidases belong to the MEROPS peptidase family M8 (leishmanolysin family, clan MA(M)). The protein fold of the peptidase domain for members of this family resembles that of thermolysin, the type example for clan MA.

Leishmanolysin (3.4.24.36) is an enzyme found in eukaryotes including Leishmania and related parasitic protozoa . The endopeptidase is the most abundant protein on the cell surface during the promastigote stage of the parasite, and is attached to the membrane by a glycosylphosphatidylinositol anchor . In the amastigote form, the parasite lives in lysosomes of host macrophages, producing a form of the protease that has an acidic pH optimum . This differs from most other metalloproteases and may be an adaptation to the environment in which the organism survives .

Tris entry also includes proteins from humans and other chordates, including Leishmanolysin-like peptidase or invadolysin  and Ciliated left-right organizer metallopeptidase, CIROP). CIROP plays a role in left-right patterning process .
Pfam PF08443: RimK-like ATP-grasp domain (domain)
This ATP-grasp domain is found in the ribosomal S6 modification enzyme RimK.
Pfam PF19779: Family of unknown function (DUF6264) (family)
This family of putative integral membrane proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 179 and 218 amino acids in length.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF19853: Family of unknown function (DUF6328) (family)
This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0000219) is described by MIBiG as an example of the following biosynthetic classes, polyketide and saccharide, in  particular the elloramycin biosynthetic gene cluster from Streptomyces olivaceus. This family appears to be predominantly found in Actinobacteria.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF20173: RZ type zinc finger domain (domain)
This entry represents the RZ type zinc finger domain, found in NFX1-type zinc finger-containing protein 1 (ZNFX1) and E3 ubiquitin-protein ligase RNF213 from humans. It contains two conserved histidine residues and four conserved cysteine residues in a CHC3H motif. It can bind divalent transition metals, with a preference for Zn2+. ZNFX1 is an RNA-binding protein that initiates the antiviral response and is required to restrict the replication of RNA viruses. RNF213 is a giant E3 ubiquitin ligase that can catalyse ubiquitination of both proteins and lipids, which is involved in various processes, such as lipid metabolism, angiogenesis and cell-autonomous immunity. It functions as a key immune sensor by catalysing ubiquitination of the lipid A moiety of bacterial LPS via its RZ-type zinc-finger and restricts the proliferation of cytosolic bacteria. RNF213 is a major susceptibility factor of Moyamoya disease.
Pfam PF22229: CofB C-terminal domain (domain)
CofB is a minor pilin involved in type IV pili assembly. It consists of a pilin domain at the N-terminal, followed by a beta-repeat hinge-like domain and a C-terminal beta-sheet-rich domain, similar to H-type lectins. This entry represents the C-terminal domain which is required for CofB to initiate pilus assembly.
Pfam PF21368: AI2M/AI1M-like, HNH endonuclease (domain)
This is the HNH endonuclease domain found in a set of group II intron proteins, including AIM1/2 from yeast and its orthologue from S. pombe. This domain is also found in related bacterial sequences.
Pfam PF06335: Protein of unknown function (DUF1054) (family)
This family consists of several hypothetical bacterial proteins of unknown function.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF10210: Mitochondrial 28S ribosomal protein S32 (family)
This entry is of a family of short, approximately 100 amino acid residues, proteins which are mitochondrial 28S ribosomal proteins named as MRP-S32.        Their exact function could not be confirmed.
Pfam PF06726: Bladder cancer-related protein BC10 (family)
This family consists of a series of short proteins of around 90 residues in length. The human protein [swissprot:O60629] or BC10 has been implicated in bladder cancer where the transcription of the gene coding for this protein is nearly completely abolished in highly invasive transitional cell carcinomas (TCCs). The protein is a small globular protein containing two transmembrane helices, and it is a multiply edited transcript.  All the editing sites are found in either the 5'-UTR or the N-terminal section of the protein, which is predicted to be outside the membrane. The three coding edits are all non-synonymous and predicted to encode exposed residues. The function of this family is unknown.
Pfam PF11979: Smad anchor for receptor activation-like, C-terminal (domain)
This domain is found at the C-terminal end of a group of animal zinc finger FYVE domain-containing proteins, including Smad anchor for receptor activation (SARA), which plays a significant role in TGF-mediated signalling. This domain is involved in the interaction with the TGF-beta receptor. This domain is found associated with [pfam:PF01363].
Pfam PF24993: Stalled ribosome sensor GCN1 N-terminal (repeat)
This entry represents a set of four HEAT repeats found towards the N-terminal of the stalled ribosome sensor GCN1, a ribosome collision sensor that plays a key role in the RNF14-RNF25 translation quality control pathway, a pathway that takes place when a ribosome has stalled during translation, and which promotes ubiquitination and degradation of translation factors on stalled ribosomes. This entry also includes ILA from Arabidopsis, a protein involved in immunity against bacterial infection and in non-host resistance.
Pfam PF05105: Bacteriophage holin family (family)
Phage holins and lytic enzymes are both necessary for bacterial lysis and virus dissemination. This family also includes TcdE/UtxA involved in toxin secretion in Clostridium difficile. The 1.E.10 family is represented by Bacillus subtilis phi29 holin; 1.E.16 represents the Cph1 holin; and the 1.E.19 family is represented by the Clostridium difficile TcdE holin. Toxigenic strains of C. difficile produce two large toxins (TcdA and TcdB) encoded within a pathogenicity locus. tcdE, encoded between tcdA and tcdB, encodes a 166 aa protein which causes death to E. coli when expressed, and the structure of TcdE resembles holins. TcdE acts on the bacterial membrane. Since TcdA and TcdB lack signal peptides, they may be released via TcdE either prior to or subsequent to cell lysis.
Pfam PF02117: Serpentine type 7TM GPCR chemoreceptor Sra (family)
Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Sra is part of the Sra superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.
Wikipedia: Nematode chemoreceptors are chemoreceptors of nematodes. Animals recognise a wide variety of chemicals using their senses of taste and smell. The nematode Caenorhabditis elegans has only 14 types of chemosensory neuron, yet is able to respond to dozens of chemicals because each neuron detects several stimuli. More than 40 highly divergent transmembrane proteins that could contribute to this functional diversity have been described. Most of the candidate receptor genes are in clusters of similar genes; 11 of these appear to be expressed in small subsets of chemosensory neurons. A single type of neuron can potentially express at least 4 different receptor genes. Some of these might encode receptors for water-soluble attractants, repellents and pheromones, which are divergent members of the G-protein-coupled receptor family. Sequences of the Sra family of C. elegans receptor-like proteins contain 6-7 hydrophobic, putative transmembrane, regions. These can be distinguished from other 7TM proteins by their own characteristic TM signatures.
Pfam PF04140: Isoprenylcysteine carboxyl methyltransferase (ICMT) family (family)
The isoprenylcysteine o-methyltransferase ([ec:2.1.1.100]) family carry out carboxyl methylation of cleaved eukaryotic proteins that terminate in a CaaX motif. In Saccharomyces cerevisiae this methylation is carried out by Ste14p, an integral endoplasmic reticulum membrane protein. Ste14p is the founding member of the isoprenylcysteine carboxyl methyltransferase (ICMT) family, whose members share significant sequence homology.
Wikipedia: The isoprenylcysteine o-methyltransferase carries out carboxyl methylation of cleaved eukaryotic proteins that terminate in a CaaX motif. In Saccharomyces cerevisiae this methylation is carried out by Ste14p, an integral endoplasmic reticulum membrane protein. Ste14p is the founding member of the isoprenylcysteine carboxyl methyltransferase (ICMT) family, whose members share significant sequence homology.
Pfam PF13467: Ribbon-helix-helix domain (domain)
This short bacterial protein contains a ribbon-helix-helix domain that is likely to be DNA-binding.
Pfam PF17447: Uncharacterized YkpC-like (family)
This is a family of unknown function found in Bacillus.
Pfam PF04168: A predicted alpha-helical domain with a conserved ER motif. (family)
An uncharacterized alpha helical domain containing a highly conserved ER motif and typically found as a tandem duplication. Contextual analysis suggests that it functions in a distinct peptide  synthesis/modification system comprising of a transglutaminase,  a peptidase of the NTN-hydrolase superfamily, an active and inactive  circularly permuted ATP-grasp domains and a transglutaminase fused  N-terminal to a circularly permuted COOH-NH2 ligase domain.
Pfam PF19207: Family of unknown function (DUF5879) (family)
This is a family of uncharacterised proteins of unknown function predominantly found in viruses.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF20181: Family of unknown function (DUF6544) (domain)
This entry represents a set of uncharacterised proteins found in bacteria. They share remote similarity to LolA, LolB outer-membrane lipoproteins.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF03689: Nepovirus coat protein, N-terminal domain (domain)
The members of this family are derived from nepoviruses. Together with comoviruses and picornaviruses, nepoviruses are classified in the picornavirus superfamily of plus strand single-stranded RNA viruses. This family aligns several nepovirus coat protein sequences. In several cases, this is found at the C-terminus of the RNA2-encoded viral polyprotein. The coat protein consists of three trapezoid-shaped beta-barrel domains, and forms a pseudo T = 3 icosahedral capsid structure.
Pfam PF03362: Herpesvirus UL47 protein (family)
The herpes simplex virus type 1 gene UL47 encodes the tegument proteins referred to collectively as VP13/14, which are believed to be differentially modified forms of the same protein. These proteins have been show to target to the nucleus. The function of this family is unknown but it contains a number of Herpesviridae proteins.
Pfam PF04404: ERF superfamily (family)
The DNA single-strand annealing proteins (SSAPs), such as RecT, Red-beta, ERF and Rad52, function in RecA-dependent and RecA-independent DNA recombination pathways. This family includes proteins related to ERF.
Pfam PF07898: Protein of unknown function (DUF1676) (family)
This family contains sequences derived from proteins of unknown function expressed by Drosophila melanogaster and Anopheles gambiae.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF24315: Domain of unknown function (DUF7489) (domain)
This entry represents a domain from uncharacterised proteins mainly found in Actinomycetes. They are predicted to adopt an OB fold-like beta-barrel.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF00956: Nucleosome assembly protein (NAP) (family)
NAP proteins are involved in moving histones into the nucleus, nucleosome assembly and chromatin fluidity.  They affect the transcription of many genes.
Pfam PF22430: Ago, N-terminal domain (domain)
This entry represents the N-terminal domain of Argonaute (Ago) from Aquifex aeolicus. This domain is composed of an antiparallel five-stranded beta sheet core that has one alpha helix positioned along one face of the sheet. Ago use short ssDNA sequences as guides (gDNA) to bind complementary target strands, resulting in cleavage of the target RNA.
Pfam PF09310: POU domain, class 2, associating factor 1 (domain)
Members of this family are transcriptional coactivators that specifically associate with either OCT1 or OCT2, through recognition of their POU domains. They are essential for the response of B-cells to antigens and required for the formation of germinal centres.