SII-SWORD/CoKE huggingface dataset:
Pfam PF24787: Testis-expressed protein 47 (domain)
This domain is found in the human Testis-expressed protein 47 (TEX47) and related proteins from animals. This domain has a detectable similarity to domains that are members of Acylphosphatase/BLUF domain-like superfamily and are predicted to adopt similar structure.
Pfam PF22818: ApeI dehydratase (domain)
This entry represents the homologues of ApeI dehydratase. This enzyme forms a heterodimer with ApeP that carries out dehydratation in APE biosynthesis. Both subunits in this complex adopt a typical hotdog fold comprising six antiparallel beta-strands and a central alpha-helix.
Pfam PF20540: Family of unknown function (DUF6755) (family)
This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 80 amino acids in length.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF16545: Cerebral cavernous malformation protein, harmonin-homology (domain)
CCM2_HHD is a folded-helical region of a family of vertebral proteins, mutations in which cause cerebral cavernous malformations (CCMs). These malformations are congenital vascular anomalies of the central nervous system that can result in haemorrhagic stroke, seizures, recurrent headaches, and focal neurologic deficits. This domain is structurally homologous to the N-terminal domain of harmonin, so it is named the CCM2 harmonin-homology domain or CCM2_HHD. This protein is often called Malcavernin.
Pfam PF04000: Sas10/Utp3/C1D family (family)
This family contains Utp3 and LCP5 which are components of the U3 ribonucleoprotein complex. It also includes the human C1D protein and Saccharomyces cerevisiae YHR081W (rrp47), an exosome-associated protein required for the 3' processing of stable RNAs, and Sas10 which has been identified as a regulator of chromatin silencing. This family also includes the human protein Neuroguidin an initiation factor 4E (eIF4E) binding protein.
Pfam PF08977: Bypass of Forespore C, N terminal (domain)
The N-terminal domain of 'bypass of forespore C' is composed of a four-stranded beta-sheet covered by an alpha-helix. The beta-sheet has a beta2-beta1-beta4-beta3 topology, where strands beta1 and beta2 and strands beta3 and beta4 are connected by beta-turns, whereas strands beta2 and beta3 are joined by an alpha-helix that runs across one face of the beta-sheet. This domain is similar to the third immunoglobulin G-binding domain of protein G from Streptococcus, the latter belonging to a large and diverse group of cell surface-associated proteins that bind to immunoglobulins. It has been hypothesised that this domain may be a mediator of protein-protein interactions involved in proteolytic events at the cell surface.
Pfam PF17103: Stealth protein CR4, conserved region 4 (family)
Stealth_CR4 is the fourth highly conserved region on stealth proteins in metazoa and bacteria. There are four CR regions on mammalian members.  CR4 carries a well-conserved CLND sequence-motif. The domain is found in tandem with CR1, CR2 and CR3 on both potential metazoan hosts and on pathogenic eubacterial species that are capsular polysaccharide phosphotransferases.  The CR domains also appear on eukaryotic proteins such as GNPTAB, N-acetylglucosamine-1-phosphotransferase subunits alpha/beta. Horizontal gene-transfer seems to have occurred between host and bacteria of these sequence-regions in order for the bacteria to evade detection by the host innate immune system.
Pfam PF04740: LXG domain of WXG superfamily (family)
This domain is present is the N-terminal region of a group of polymorphic toxin proteins in bacteria. It is predicted  to use Type VII secretion pathway to mediate export of bacterial toxins.
Pfam PF08148: DSHCT (NUC185) domain (domain)
This C terminal domain is found in DOB1/SK12/helY-like DEAD box helicases.
Pfam PF20207: Family of unknown function (DUF6568) (family)
This family of proteins is functionally uncharacterised. This family of proteins is mainly found in Firmicutes. Proteins in this family are approximately 170 amino acids in length. There are two conserved motifs, CxxF and YxN, and two conserved residues, Tyr at the N-terminal and a Gly at the C-terminal. Many members of this family are thought to belong to the Thioredoxin superfamily.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF20565: Probable metallopeptidase family (DUF6775) (domain)
This family is functionally uncharacterised. This domain family is found in archaea. An AlphaFold prediction shows close similarity to zinc dependent peptidases.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF11830: Domain of unknown function (DUF3350) (family)
This domain is functionally uncharacterised and is found in eukaryotic proteins, such as TBC1 domain family members 1 and 4. This presumed domain is typically between 50 to 64 amino acids in length. TBC domain proteins may act as GTPase-activating proteins for RAB2A, RAB8A, RAB10 and RAB14.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF05347: Complex 1 protein (LYR family) (family)
Proteins in this family include an accessory subunit of the higher eukaryotic NADH dehydrogenase complex.  In Saccharomyces cerevisiae, the Isd11 protein ([swissprot:Q6Q560]) has been shown to play a role in Fe/S cluster biogenesis in mitochondria. We have named this family LYR after a highly conserved tripeptide motif close to the N-terminus of these proteins.
Wikipedia: Respiratory complex I, EC 7.1.1.2 is the first large protein complex of the respiratory chains of many organisms from bacteria to humans. It catalyzes the transfer of electrons from NADH to coenzyme Q10 (CoQ10) and translocates protons across the inner mitochondrial membrane in eukaryotes or the plasma membrane of bacteria.
Pfam PF08200: Bacteriophage 1.1 Protein (family)
Gene 1.1 in Bacteriophage T7 encodes a 42 amino acid protein, rich in basic amino acids suggesting its interaction with nucleic acids.  Many homologs are present in different T7 and T3-like bacteriophage.
Pfam PF01661: Macro domain (domain)
The Macro or A1pp domain is a module of about 180 amino acids which can bind ADP-ribose (an NAD metabolite) or related ligands. Binding to ADP-ribose could be either covalent or non-covalent: in certain cases it is believed to bind non-covalently; while in other cases (such as Aprataxin) it appears to bind both non-covalently through a zinc finger motif, and covalently through a separate region of the protein. This domain is found in a number of otherwise unrelated proteins. It is found at the C-terminus of the macro-H2A histone protein 4 and also in the non-structural proteins of several types of ssRNA viruses such as NSP3 from alpha-viruses and coronaviruses. This domain is also found on its own in a family of proteins from bacteria, archaebacteria and eukaryotes.    The 3D structure of the SARS-CoV Macro domain has a mixed alpha/beta fold consisting of a central seven-stranded twisted mixed beta sheet sandwiched between two alpha helices on one face, and three on the other. The final alpha-helix, located on the edge  of the central beta-sheet, forms the C terminus of the protein.   The crystal structure of AF1521 (a Macro domain-only protein from Archaeoglobus fulgidus) has also been reported and compared with other Macro domain containing proteins. Several Macro domain only proteins are shorter than AF1521, and appear to lack either the first strand of the beta-sheet or the C-terminal helix 5. Well conserved residues form a hydrophobic cleft and cluster around the AF1521-ADP-ribose binding site.
Wikipedia: In molecular biology, the Macro domain or A1pp domain is an ancient, evolutionary conserved structural module found in all kingdoms of life as well as some viruses. Macro domains are modules of about 180 amino acids that can bind ADP-ribose, an NAD metabolite, or related ligands. Binding to ADP-ribose can be either covalent or non-covalent: in certain cases it is believed to bind non-covalently, while in other cases it appears to bind both non-covalently through a zinc finger motif, and covalently through a separate region of the protein.
Pfam PF17658: Family of unknown function (DUF5520) (family)
This is a family of unknown function found in Mammalia.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF05912: Caenorhabditis elegans protein of unknown function (DUF870) (family)
This family consists of a number of hypothetical proteins which seem to be specific to Caenorhabditis elegans. The function of this family is unknown.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF19940: Family of unknown function (DUF6402) (family)
This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0000464) is described by MIBiG as an example of the following biosynthetic class, NRP (non-ribosomal peptide), in  particular the xenoamicin A biosynthetic gene cluster from  Xenorhabdus doucetiae. This family appears to be  predominantly found in proteobacteria.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF00499: NADH-ubiquinone/plastoquinone oxidoreductase chain 6 (family)
This entry represents chain 6 from NADH:ubiquinone oxidoreductase and NADH-plastoquinone oxidoreductase. Bacterial proton-translocating NADH-quinone oxidoreductase (NDH-1) is composed of 14 different subunits. The chain belonging to this family is a subunit that constitutes the membrane sector of the complex. It reduces ubiquinone to ubiquinol utilising NADH. Plant chloroplastic NADH-plastoquinone oxidoreductase reduces plastoquinone to plastoquinol. Mitochondrial NADH-ubiquinone oxidoreductase from a variety of sources reduces ubiquinone to ubiquinol.
Wikipedia: Respiratory complex I, EC 7.1.1.2 is the first large protein complex of the respiratory chains of many organisms from bacteria to humans. It catalyzes the transfer of electrons from NADH to coenzyme Q10 (CoQ10) and translocates protons across the inner mitochondrial membrane in eukaryotes or the plasma membrane of bacteria.
Pfam PF21782: PKMT, C-terminal winged helix domain (domain)
This entry represents the C-terminal winged helix domain of PKMTs. PKMTs are protein-lysine methyltransferases that catalyze the methylation of lysine residues on many different proteins. They consist of N-terminal S-adenosylmethionine binding domain, a middle domain and a C-terminal domain. The middle and the C-terminal domain share significant structural similarity and are both distantly related to HTH winged helix DNA-binding domains.
Pfam PF21959: Repeat of unknown function (DUF6923) (repeat)
This entry represents a beta propeller domain composed of five blades. It is often found in large extracellular proteins in one or more copies. It is uncertain whether this domain might have an enzymatic function or a ligand binding function. Structurally this domain appears to have a sixfold symmetry, but one of the blades takes up the space of normal repeats. This unusual blade is composed of three strands of the first repeat and a final C-terminal strand from the last repeat.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF05095: Protein of unknown function (DUF687) (family)
This family contains several uncharacterised Chlamydia proteins.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF11001: YDR124W-like, helical bundle domain (domain)
This entry represents mitochondrial proteins from fungi, such as subtelomeric hrmA-associated cluster protein AFUB_079030 from Aspergillus fumigatus and YDR124W from yeast. Null mutant showed severe fragmentation of mitochondria and its expression  is strongly induced by alpha factor. These proteins may have a role in maintenance of mitochondrial morphology. This entry represents an helical bundle domain which seems to adopt a similar arrangement than the EIN3-like DNA-binding domain (Based on structural comparison, DALI server). AFUB_079030 is part of the subtelomeric hrmA-associated cluster (HAC) containing genes that alter the hyphal surface (such as reduced total chitin or increased beta-glucan exposure) and perturb inter-hyphal interactions within the developing biofilms, resulting in a loss of vertically aligned polarised growing filaments.
Pfam PF17687: Family of unknown function (DUF5535) (family)
This is a family of unknown function found in mammals.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF05046: Mitochondrial large subunit ribosomal protein (Img2) (domain)
This family of proteins have been identified as part of the mitochondrial large ribosomal subunit in yeast.
Pfam PF24434: Family of unknown function (DUF7557) (family)
This entry represents a small family of uncharacterised proteins found in archaea. They may be part of toxin/antitoxin system.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF18218: Lantibiotic immunity protein Spa1 C-terminal domain (domain)
This is the C-terminal domain found in SpaI present in Bacillus subtilis. SpaI is an immunity lipoprotein that protects the Gram-positive bacteria against their own lantibiotics, in this case subtilin. SpaI together with the ABC transporter SpaFEG protects the membrane from subtilin insertion.
Pfam PF05416: Southampton virus-type processing peptidase (family)
Corresponds to Merops family C37. Norwalk-like viruses (NLVs), including the Southampton virus, cause acute non-bacterial gastroenteritis in humans. The NLV genome encodes three open reading frames (ORFs). ORF1 encodes a polyprotein, which is processed by the viral protease into six proteins.
Pfam PF15232: Domain of unknown function (DUF4585) (family)
The function of this protein domain family is yet to be characterised. It is putatively thought to lie in the C-terminal domain of the DNA nucleotide repair protein, Xeroderma pigmentosa complementation group A (XPA). The function of XPA is to bind to DNA and repair any mismatched base pairs.  This domain family is often found in eukaryotes, and is approximately 70 amino acids in length. There is a conserved DPE sequence motif. In humans, this protein is encoded for in the chromosomal position, Chromosome 5 open reading frame 65. Mutations in the gene lead to myelodysplastic syndromes, where there is inefficient stem cell production in the bone marrow. This suggests that the protein may have a role in forming blood cells.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF21435: Shigella glutamine deamidase OspI (domain)
This entry represents OspI, a Shigella flexneri effector encoded by ORF169b that suppresses the TNF-receptor-associated factor 6 (TRAF6)-mediated signalling pathway and inhibits acute inflammatory responses in the initial stage of infection. This is a glutamine deamidase essential for the deamidation of UBC13.
Pfam PF13879: Hemingway/CFA97 (family)
Drosophila Hemingway (Hmw) is required for motile cilia function and sperm flagella assembly. The human orthologue, known as cilia- and flagella-associated protein 97 (CFAP97) or KIAA1430, localises to the primary cilium. Another member of this family is the uncharacterised protein CFAP97D1/2 (CFAP97 domain-containing protein 1/2).
Pfam PF21974: Snurportin1, m3G cap-binding domain (domain)
This entry represents the m3G cap-binding domain of Snurportin1 (SPN1), a nuclear import adaptor for m3G-capped spliceosomal U small nucleoproteins (snRNPs). After capping and assembly, the U snRNPs are transported into the nucleus by SPN1 and importin beta; SPN1 is then returned to the cytoplasm by exportin 1 (CRM1).
Pfam PF24964: Domain of unknown function (DUF7769) (domain)
This is a presumed domain found in plant sequences. It may consist in a tri-helical fold.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF16622: zinc-finger C2H2-type (domain)
Zinc-finger of C2H2 type found in higher eukaryotes.
Wikipedia: A zinc finger is a small protein structural motif that is characterized by the coordination of one or more zinc ions (Zn2+) which stabilizes the fold. It was originally coined to describe the finger-like appearance of a hypothesized structure from the African clawed frog (Xenopus laevis) transcription factor IIIA. However, it has been found to encompass a wide variety of differing protein structures in eukaryotic cells. Xenopus laevis TFIIIA was originally demonstrated to contain zinc and require the metal for function in 1983, the first such reported zinc requirement for a gene regulatory protein followed soon thereafter by the Krüppel factor in Drosophila. It often appears as a metal-binding domain in multi-domain proteins.
Pfam PF23873: Family of unknown function (DUF7228) (family)
This family of uncharacterized proteins is found in several Lactococcus phages. All members are short proteins, between 33-59 amino acids in length. The family shows some conserved polar residues at the N-terminus. These proteins appear to be disordered.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF22622: MFE-2 hydratase 2 N-terminal domain (domain)
This entry represents a domain found in N-terminal in MFE-2 hydratase 2 and related enzymes. This domain is housing the cavity for the aliphatic acyl part of the substrate molecule. The flexibility of region within this domain plays a role in substrate binding in mammalian hydratase 2.
Pfam PF09813: Cytochrome c oxidase assembly factor 3 (coiled_coil)
This entry represents a coiled-coil domain found in cytochrome c oxidase assembly factor 3 and homologues. Cytochrome c oxidase assembly factor 3, previously known as coiled coil domain-containing protein 56 (CCDC56), plays a critical role in the biogenesis and activity of cytochrome c oxidase (COX).
Wikipedia: The enzyme cytochrome c oxidase or Complex IV is a large transmembrane protein complex found in bacteria, archaea, and the mitochondria of eukaryotes.
Pfam PF02144: Repair protein Rad1/Rec1/Rad17 (family)
This family consists of the repair proteins Rad1, Rec1 and Rad17.

Rad1 is a component of the 9-1-1 cell-cycle checkpoint response complex (Rad9-Rad1-Hus1) that plays a major role in DNA repair . Rad1 isoform 1 possesses 3'->5' double stranded DNA exonuclease activity .

Rec1 of Ustilago maydis plays a key role in regulating the genetic system of this fungus. Rec1 mutants are very sensitive to UV light. Mutation leads to a complex phenotype with alterations in DNA repair, recombination, mutagenesis, meiosis and cell division . Rec1 shows 3'--5' exonuclease activity, but only in cells over-expressing Rec1.