SII-SWORD/CoKE huggingface dataset:
Pfam PF19492: Family of unknown function (DUF6027) (family)
This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0001387) is described by MIBiG as an example of the following biosynthetic class, other (unspecified). This family  includes a protein from the nucleocidin biosynthetic gene cluster  from Streptomyces calvus and appear to be predominantly found in  Actinobacteria.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF13757: Vault protein inter-alpha-trypsin domain (domain)
Inter-alpha-trypsin inhibitors (ITIs) consist of one light chain and a variable set of heavy chains.  ITIs play a role in extracellular matrix (ECM) stabilisation and tumour metastasis as well as in plasma protease inhibition.  The vault protein inter-alpha-trypsin (VIT) domain described here is found to the N-terminus of a von Willebrand factor type A domain ([pfam:PF00092]) in ITI heavy chains (ITIHs) and their precursors.
Pfam PF23302: DNAJC9 HTH domain (domain)
This domain is found in human DnaJ homolog subfamily C member 9 (DNAJC9) and related proteins. DNAJC9 acts as a dual histone chaperone and heat-shock co-chaperone. This protein was shown to also assemble histones onto DNA in vitro. The domain represented in this entry has a weak similarity to HTH domains and it is predicted to adopt similar three helical bundle.
Pfam PF13558: SbcC/RAD50-like, Walker B motif (domain)
This entry represents the Walker B domain of RAD50 from eukaryotes and the prokaryotic homologue SbcCD complex subunit C. RAD50-ATPase forms a complex with Mre11-nuclease that detects and processes diverse and obstructed DNA ends. This domain is separated of the Walker A domain by a long coiled-coil domain and forms the nucleotide-binding domain (NBD) when the coiled coils fold back on themselves and bring together Walker A and B domains. Two RAD50-NBDs forms heterotetramers with a Mre11 nuclease dimer that assemble as catalytic head module that binds and cleaves DNA in an ATP-dependent reaction. Through secondary structural analysis, it has been suggested that there is a wide structural conservation in the Rad50/SMC protein family as seen in structural similarities between RAD50's hook and ABC-ATPase MukB's elbow region.
Pfam PF22950: Domain of unknown function (DUF7026) (domain)
This entry represents a helical domain found in plant proteins. The function of these proteins is unknown.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF02322: Cytochrome bd terminal oxidase subunit II (family)
This family consists of cytochrome bd type terminal oxidases that catalyse quinol-dependent, Na+-independent oxygen uptake. Members of this family are integral membrane proteins and contain a protohaem IX centre B558. One member of the family [swissprot:O05192] is implicated in having an important role in micro-aerobic nitrogen fixation in the enteric bacterium Klebsiella pneumoniae. The family forms an integral functional unit with subunit I, family Bac_Ubq_Cox, [pfam:PF01654].
Wikipedia: Ubiquinol oxidase (H+-transporting) (EC 7.1.1.3, cytochrome bb3 oxidase, cytochrome bo oxidase, cytochrome bd-I oxidase) is an enzyme with systematic name ubiquinol:O2 oxidoreductase (H+-transporting). This enzyme catalyses the following chemical reaction2 ubiquinol + O2 + n H+in  2 ubiquinone + 2 H2O + n H+out
Pfam PF24310: THSD1 second Ig-like domain (domain)
This domain is found in the human Thrombospondin type-1 domain-containing protein 1 (THSD1) and related proteins. THSD1 is involved in endothelial cell to extracellular matrix adhesion. THSD1 forms a multimeric protein complex with FAK/talin/ vinculin, wherein THSD1 promotes talin binding to FAK but not to vinculin, a key step in nascent adhesion assembly. The domain represented by this entry is predicted to adopt Ig-like beta-sandwich.
Pfam PF05615: Tho complex subunit 7 (family)
The Tho complex is involved in transcription elongation and mRNA export from the nucleus.
Pfam PF13269: Protein of unknown function (DUF4060) (family)
This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 80 amino acids in length. There are two conserved sequence motifs: VEVV and SYVAT.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF12231: Rap1-interacting factor 1 N terminal (family)
This domain family is found in eukaryotes, and is typically between 135 and 146 amino acids in length. Rif1 is a protein which interacts with Rap1 to regulate telomere length. Interaction with telomeres limits their length. The N terminal region contains many HEAT- and ARMADILLO- type repeats. These are helical folds which form extended curved proteins or RNA interface surfaces.
Pfam PF01279: Parathyroid hormone family (family)
Parathyroid hormone (PTH) is a polypeptidic hormone that elevates calcium level by dissolving the salts in bone and preventing their renal excretion. Parathyroid hormone-related protein (PTH-rP) is structurally related to PTH  and seems to play a physiological role in lactation, possibly as a hormone for the mobilisation and/or transfer of calcium to the milk. It also regulates chondrocytic differentiation and endochondral bone formation .

PTH and PTH-rP bind to the same G-protein coupled receptor.
This entry represents parathyroid hormone and parathyroid hormone-related protein.
Wikipedia: The parathyroid hormone family is a family of structurally and functionally related proteins. Parathyroid hormone (PTH) is a polypeptidic hormone primarily involved in calcium metabolism. The parathyroid hormone-related protein (PTH-rP) is a related protein with predominantly paracrine function and possibly an endocrine role in lactation, as PTHrP has been found to be secreted by mammary glands into the circulation and increase bone turnover. PTH and PTH-rP bind to the same G-protein coupled receptor. The related protein PTH-L has been found in teleost fish, which also have two forms of PTH and PTHrP. Three subfamilies can be identified: PTH, PTHrP and PTH-L.
Pfam PF23602: Dynein axonemal assembly factor 11-like, CS domain (domain)
This domain is found at the C-terminal end of human Dynein axonemal assembly factor 11 (DNAAF11) and similar sequences mainly found in animals. DNAAF11 is involved in dynein arm assembly. It is predicted to fold into a beta-sandwich domain and show structural similarity to the CS domain ([pfam:PF04969]).
Pfam PF24746: Domain of unknown function (DUF7694) (domain)
This entry represents a domain found in uncharacterised bacterial proteins. They are predicted to adopt a globular structure consisting of an antiparallel beta-sheet and alpha helix packed on it. Most members contain a highly conserved HhW sequence motif where h is hydrophobic residue.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF19633: Protein SET DOMAIN GROUP 2 C-terminal (domain)
Histone-lysine N-methyltransferase ATXR3, also known as protein SET DOMAIN GROUP 2 (SDG2), is a histone methyltransferase specifically required for trimethylation of Lys-4 of histone H3 (H3K4me3) and is crucial for both sporophyte and gametophyte development. This is the POST_SET domain located at the C-terminal of SDG2, although there is no significant sequence homology with other Arabidopsis SDGs outside of the SET domain.
Pfam PF00106: short chain dehydrogenase (domain)
This family contains a wide variety of dehydrogenases.
Wikipedia: The short-chain dehydrogenases/reductases family (SDR) is a very large family of enzymes, most of which are known to be NAD- or NADP-dependent oxidoreductases. As the first member of this family to be characterised was Drosophila alcohol dehydrogenase, this family used to be called 'insect-type', or 'short-chain' alcohol dehydrogenases. Most members of this family are proteins of about 250 to 300 amino acid residues. Most dehydrogenases possess at least 2 domains, the first binding the coenzyme, often NAD, and the second binding the substrate. This latter domain determines the substrate specificity and contains amino acids involved in catalysis. Little sequence similarity has been found in the coenzyme binding domain although there is a large degree of structural similarity, and it has therefore been suggested that the structure of dehydrogenases has arisen through gene fusion of a common ancestral coenzyme nucleotide sequence with various substrate specific domains.
Pfam PF13264: Domain of unknown function (DUF4055) (family)
This presumed domain is functionally uncharacterised. This domain family is found in bacteria and viruses, and is approximately 140 amino acids in length.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF22144: Fungal virus Capsid protein, C-terminal domain (domain)
This domain is found at the C-terminal end of Capsid protein from Penicillium chrysogenum virus (P2), which self-assembles to form an icosahedral capsid with a T=1 symmetry. It is organised into two domains with similar alpha-beta  morphology.
Pfam PF19395: Family of unknown function (DUF5970) (family)
This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0000616) is described by MIBiG as an example of the following biosynthetic class, RiPP (ribosomally synthesised and post-translationally modified peptide).
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF19111: Family of unknown function (DUF5798) (family)
Family of unknown function predominantly found in Halobacteria.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF09791: Oxidoreductase-like protein, N-terminal (family)
Members of this family are found in the N terminal region of various oxidoreductase like proteins. Their exact function is, as yet, unknown.
Pfam PF17793: ANC1 homology domain (AHD) (domain)
This entry corresponds to the ANC1 homology domain (AHD) found in AF-9.
Pfam PF12947: EGF domain (domain)
This family includes a variety of EGF-like domain homologues. This family includes the C-terminal domain of the malaria parasite MSP1 protein.
Pfam PF07520: Virulence factor SrfB (family)
This family includes homologues of  SsrAB is a two-component regulatory system encoded within the Salmonella pathogenicity island SPI-2.  Among the products of genes activated by SsrAB within epithelial and macrophage cells is [swissprot:Q9KIJ9]. Homologues are found in several other proteobacteria.
Pfam PF23696: YneP (family)
This protein family includes Protein YneP from Escherichia coli, a 40-residues long sequence.
Pfam PF18043: T4 RNA ligase 2 C-terminal (domain)
This is the C-terminal domain of Enterobacteria phage T4 RNA ligase 2 (Rnl2). The C-terminal domain consists of a four-helix bundle. The C-terminal domain is thought to be critical for binding the Rnl2 to adenylylated nicked duplex. This is known as step 2 of the ligation pathway.
Pfam PF23608: ILCR1 Ig-like domain (domain)
This domain is found in Interleukin cytokine receptor-related protein 1 (ILCR1) from C.elegans and related proteins. This protein forms a receptor complex together with receptor ILCR2, which upon activation acts as a modulator of neuronal activity. When IL-17 binds to the ILCR-1/2 receptor complex, a signaling cascade is triggered that activates the downstream signaling components and results in increased neuronal activity in response to input from oxygen-sensing neurons. The domain represented by this entry is predicted to adopt a beta-sandwich with Ig-like topology.
Pfam PF07443: HepA-related protein (HARP) (family)
This family represents a conserved region approximately 60 residues long within eukaryotic HepA-related protein (HARP). This exhibits single-stranded DNA-dependent ATPase activity, and is ubiquitously expressed in human and mouse tissues. Family members may contain more than one copy of this region.
Pfam PF02082: Iron-dependent Transcriptional regulator (domain)
Several proteins in this family form iron-sulfur clusters enabling iron dependent DNA transcription regulation. The iron binding is mediated by three conserved cysteine residues. Members of this family can also bind O-acetyl-L-serine, [Fe-S] and nitric oxide (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).
Pfam PF24414: Family of unknown function (DUF7547) (family)
This entry represents a group of uncharacterised archaeal proteins. These proteins probably do not adopt a globular structure.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF08630: Dfp1/Him1, central region (family)
This is the middle regions described by Ogino et al.  This region, together with the C-terminal zinc finger ([pfam:PF07535]) is essential for the mitotic and kinase activation functions of Dfp1/Him1.
Pfam PF17008: Domain of unknown function (DUF5088) (family)
This is a family of microsporidial sequences of unknown function.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF07531: NHR1 homology to TAF (family)
This corresponds to the region NHR1 that is  conserved between the product of the nervy gene in Drosophila and the human mtg8b protein, which is hypothesised to be a transcription factor.
Wikipedia: The TBP-associated factors (TAF) are proteins that associate with the TATA-binding protein in transcription initiation. It is a part of the transcription initiation factor TFIID multimeric protein complex. It also makes up many other factors, including SL1. They mediate the formation of the transcription preinitiation complex, a step preceding transcription of DNA to RNA by RNA polymerase II.
Pfam PF12819: Malectin-like domain (domain)
Malectin is a membrane-anchored protein of the endoplasmic reticulum that recognises and binds Glc2-N-glycan. The domain is found on a number of plant receptor kinases and is distantly related to malectin domains.
Pfam PF02767: DNA polymerase III beta subunit, central domain (domain)
A dimer of the beta subunit of DNA polymerase beta forms a ring which encircles duplex DNA.  Each monomer contains three domains of identical topology and DNA clamp fold.
Wikipedia: A DNA clamp, also known as a sliding clamp, is a protein complex that serves as a processivity-promoting factor in DNA replication. As a critical component of the DNA polymerase III holoenzyme, the clamp protein binds DNA polymerase and prevents this enzyme from dissociating from the template DNA strand. The clamp-polymerase protein–protein interactions are stronger and more specific than the direct interactions between the polymerase and the template DNA strand; because one of the rate-limiting steps in the DNA synthesis reaction is the association of the polymerase with the DNA template, the presence of the sliding clamp dramatically increases the number of nucleotides that the polymerase can add to the growing strand per association event. The presence of the DNA clamp can increase the rate of DNA synthesis up to 1,000-fold compared with a nonprocessive polymerase.
Pfam PF09849: Uncharacterized protein conserved in bacteria (DUF2076) (family)
This domain, found in various hypothetical prokaryotic proteins, has no known function. The domain, however, is found in various periplasmic ligand-binding sensor proteins.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF00104: Ligand-binding domain of nuclear hormone receptor (domain)
This all helical domain is involved in binding the hormone in these receptors.
Wikipedia: In the field of molecular biology, nuclear receptors are a class of proteins responsible for sensing steroids, thyroid hormones, vitamins, and certain other molecules. These intracellular receptors work with other proteins to regulate the expression of specific genes, thereby controlling the development, homeostasis, and metabolism of the organism.
Pfam PF24309: IMEF cargo Flp protein (family)
This entry represents the IMEF cargo Flp protein from Bacillus thermotolerans and related proteins. This protein is a cargo protein of a type 1 encapsulin nanocompartment which is probably involved in iron mineralization. It adopts a four-helical bundle fold. It has ferroxidase activity even when encapsulated, the rate is probably controlled by the rate of Fe flux across the nanocompartment pores.
Pfam PF11792: Baculoviridae late expression factor 5 C-terminal domain (domain)
This C-terminal domain is likely to be a zinc-binding domain.
Pfam PF20764: Domain of unknown function (DUF6837) (domain)
This domain is found in proteins from tailed bacteriophages and eukaryotes, including 201phi2-1p060 from Pseudomonas phage 201phi2-1 Its function is unknown.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF18500: CadC C-terminal domain 1 (domain)
CadC is an integral membrane protein of 512 amino acids comprising an N-terminal cytoplasmic DNA-binding domain, a transmembrane helix, and a C-terminal periplasmic domain. CadC belongs to the ToxR-like regulators that encompass biochemically non-modified one-component systems with similar gross topology, including several low pH-induced transcription regulators. Structural analysis of the C-terminal periplasmic domain indicates that it resembles the sensory domain of a (pH-activated) ToxR-like regulator. Furthermore, it is composed of two subdomains with a cavity at their interface that is suited to accommodate cadaverine, the feedback inhibitor of the Cad system. This is the N-terminal subdomain of the C-terminal periplasmic domain. It is composed of five-stranded beta-sheets.
Pfam PF01091: PTN/MK heparin-binding protein family, C-terminal domain (domain)
Several extracellular heparin-binding proteins involved in regulation of growth and differentiation belong to a new family of growth factors. These growth factors are highly related proteins of about 140 amino acids that contain 10 conserved cysteines probably involved in disulphide bonds, and include pleiotrophin  (also known as heparin-binding growth-associated molecule HB-GAM, heparin-binding growth factor 8 HBGF-8, heparin-binding neutrophic factor HBNF and osteoblast specific protein OSF-1); midkine (MK) ; retinoic acid-induced heparin-binding protein (RIHB) ; and pleiotrophic factors alpha-1 and -2 and beta-1 and -2 from Xenopus laevis, the homologues of midkine and pleiotrophin respectively. Pleiotrophin is a heparin-binding protein that has neurotrophic activity and has mitogenic activity towards fibroblasts. It is highly expressed in brain and uterus tissues, but is also found in gut, muscle and skin. It is thought to possess an important brain-specific function. Midkine is a regulator of differentiation whose expression is regulated by retinoic acid, and, like pleiotrophin, is a heparin-binding growth/differentiation factor that acts on fibroblasts and nerve cells.
This entry represents the C-terminal domain of pleiotrophin and midkine .
Pfam PF09528: Ehrlichia tandem repeat (Ehrlichia_rpt) (repeat)
This entry represents 30 amino acid tandem repeat, found in a variable number of copies in an immunodominant outer membrane protein of Ehrlichia chaffeensis, a tick-borne obligate intracellular pathogen. These short tandem-repeats elicit a strong antibody response in the hosts.
Pfam PF07029: CryBP1 protein (family)
This family consists of several CryBP1 like proteins from Bacillus thuringiensis and Paenibacillus popilliae. Members of this family are thought to be involved in the overall toxicity of the bacteria to their hosts.