SII-SWORD/CoKE huggingface dataset:
Pfam PF11736: Protein of unknown function (DUF3299) (family)
This is a family of bacterial proteins of unknown function.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF18562: Cysteine-Rich Interdomain Region 1 gamma (domain)
Rosetting is the capacity of infected RBCs to bind uninfected RBCs, which is consistently associated with severe malaria in African children. The rosette-forming PfEMP1 adhesins, namely IT4/R29, Palo Alto 89F5 VarO, 3D7/PF13_0003 and IT4/var60, belong to a specific sub-group called groupA/UpsA var genes and all four present a specific Duffy Binding-Like and and Cysteine-Rich Interdomain Region (DBL1alpha1-CIDR1gamma) double domain Head region found at the extracellular region of PfEMP1. This entry represents the CIDR1gamma domain which increases the binding affinity to VarO (Palo Alto VarO parasites).
Wikipedia: Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) is a family of proteins present on the membrane surface of red blood cells that are infected by the malarial parasite Plasmodium falciparum. PfEMP1 is synthesized during the parasite's blood stage inside the RBC, during which the clinical symptoms of falciparum malaria are manifested. Acting as both an antigen and adhesion protein, it is thought to play a key role in the high level of virulence associated with P. falciparum. It was discovered in 1984 when it was reported that infected RBCs had unusually large-sized cell membrane proteins, and these proteins had antibody-binding (antigenic) properties. An elusive protein, its chemical structure and molecular properties were revealed only after a decade, in 1995. It is now established that there is not one but a large family of PfEMP1 proteins, genetically regulated (encoded) by a group of about 60 genes called var. Each P. falciparum is able to switch on and off specific var genes to produce a functionally different protein, thereby evading the host's immune system. RBCs carrying PfEMP1 on their surface stick to endothelial cells, which facilitates further binding with uninfected RBCs, ultimately helping the parasite to both spread to other RBCs as well as bringing about the fatal symptoms of P. falciparum malaria.
Pfam PF24507: CFAP65, fourth Ig-like domain (domain)
This entry represents the fourth Ig-like domain of CFAP65 and related sequences. CFA65 plays a role in flagellar formation and sperm motility.
Pfam PF19500: Family of unknown function (DUF6035) (family)
This family of proteins is functionally uncharacterised. This family of proteins is found in Proteobacteria and Bacteroidetes. Proteins in this family are typically between 425 and 520 amino acids in length.  There is a conserved GVD sequence motif. This family contains a PD-(D/E)XK nuclease domain.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF20383: Family of unknown function (DUF6678) (family)
This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 112 and 148 amino acids in length.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF16038: TMIE protein (family)
This family of proteins includes the mammalian transmembrane inner ear expressed protein. It's function is unknown.
Pfam PF01270: Glycosyl hydrolases family 8 (repeat)
O-Glycosyl hydrolases (3.2.1.) are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycosyl hydrolases, based on sequence similarity, has led to the definition of 85 different families . This classification is available on the CAZy (CArbohydrate-Active EnZymes) website.
Glycoside hydrolase family 8 GH8 comprises enzymes with several known activities; endoglucanase (3.2.1.4); lichenase (3.2.1.73); chitosanase (3.2.1.132). These enzymes were formerly known as cellulase family D .
Wikipedia: In molecular biology, glycoside hydrolase family 8 is a family of glycoside hydrolases EC 3.2.1., which are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycoside hydrolases, based on sequence similarity, has led to the definition of &gt;100 different families. This classification is available on the CAZy website, and also discussed at CAZypedia, an online encyclopedia of carbohydrate-active enzymes.
Pfam PF17956: Nicotinate phosphoribosyltransferase C-terminal domain (domain)
This domain is found at the C-terminus of some Nicotinate phosphoribosyltransferase enzymes.  The function of this domain is uncertain.
Pfam PF11986: Influenza A Proapoptotic protein (domain)
PB1-F2 is a protein found in almost all known strains of Influenza A virus - a negative sense ssRNA Orthomyxovirus. It originates from translation of the viral polymerase gene in an alternative reading frame. PB1-F2 consists of two independent structural domains, two closely neighboring short helices at the N terminus, and an extended C-terminal helix. Although the protein has originally been described to induce apoptosis, it has now been shown that PB1-F2 more likely acts as an apoptosis promoter in concert with other apoptosis-inducing agents. PB1-F2 promotes apoptosis by localising to the mitochondria where it destabilises the membrane. This will cause release of cytochrome C which activates the caspase cascade of apoptosis through the endogenous pathway. In this way it acts like the Bcl-2 protein family which are physiological apoptotic regulators in cells.
Pfam PF14335: Domain of unknown function (DUF4391) (family)
This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and archaea. Proteins in this family are typically between 220 and 257 amino acids in length.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF15492: Neuroblastoma-amplified sequence, N terminal (repeat)
Nbas_N is an N-terminal family of metazoan sequences. This domain lies at the N-terminal of several WD40-containing proteins. The human protein is over-expressed in neuroblastoma cells.
Pfam PF02142: MGS-like domain (domain)
This domain composes the whole protein of methylglyoxal synthetase and the domain is also found in Carbamoyl phosphate synthetase (CPS) where it forms a regulatory domain that binds to the  allosteric effector ornithine. This family also includes inosicase. The known structures in this family show a common phosphate binding site.
Pfam PF11327: Egh16-like virulence factor (family)
This eukaryotic family of proteins includes a group of fungal proteins, including Egh16 from Erysiphe graminis f.sp. hordei and its homologues. They are found in pathogenic fungi and may play important roles during the early infection stage in fungal pathogens.
Pfam PF10765: Bacteriophage P22, NinX (family)
This family is represented by Bacteriophage P22, NinX. The characteristics of the protein distribution suggest prophage matches in addition to the phage matches.
Pfam PF24801: Tip attachment protein J,FNIII-A domain (domain)
This domain is found towards the N-terminal end of Tip attachment protein J from the bacteriophage lambda (GpJ) and similar sequences from tailed bacteriophages and bacterial prophages. GpJ is involved in the induction of viral DNA ejection. It attaches the virion to the host receptor. This domain shows an Ig-like structure.
Pfam PF16433: Domain of unknown function (DUF5030) (family)
This family consists of several uncharacterized proteins around 300 in length and is mainly found in various Bacteroides species. The function of this family is unknown.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF14468: Protein of unknown function (DUF4427) (family)
This domain is often found at the C-terminal of proteins with [pfam:PF10899] domain, for instance in STY1911 protein from a multiple drug resistant Salmonella enterica serovar Typhi CT18.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF07950: MDM10-complementing protein 1, transmembrane domain (domain)
This entry represents the transmembrane domains found in MDM10-complementing protein 1 from yeast, a mitochondrial protein involved in in mitochondrial lipid homeostasis.
Pfam PF15834: Testis highly expressed protein 4 (family)
THEG4, testis highly expressed protein 4, is a family of proteins found in eukaryotes. Proteins in this family are typically between 152 and 232 amino acids in length.
Pfam PF23248: PARP14, second type I KH domain (domain)
This domain is found in human Protein mono-ADP-ribosyltransferase PARP14 and related proteins. PARP14 is a large multidomain protein which in the N-terminal half contains a series of consecutive RRM and KH domains that are known to be nucleic acid-binding. PARP14 is involved in multiple signaling pathways linked to cancer, inflammation, and infection. PARP14 is an ADP-ribosyltransferase that mediates mono-ADP-ribosylation of glutamate residues on target proteins. In contrast to PARP1 and PARP2, it is not able to mediate poly-ADP-ribosylation. The domain represented by this entry is a KH domain found second in the human PARP14.
Pfam PF16152: Domain of unknown function (DUF4860) (family)
This family consists of uncharacterized proteins around 160 residues in length and is mainly found in various Eubacterium and Clostridium species. The function of this family is unknown.
Pfam PF23103: Fifth Zinc fingers C2H2 type, ZNF451 (domain)
This entry represents the fifth Zinc Finger C2H2 type found in the ZNF451 protein. E3 SUMO-protein ligase ZNF451 is a key enzyme involved in the sumoylation process, exhibiting a preference for SUMO2 and SUMO3 over SUMO1. It facilitates the UBE2I/UBC9-mediated sumoylation of target proteins, particularly in response to DNA damage and proteasome inhibitors. ZNF451 is essential for MCM4 sumoylation,  and it negatively regulates transcriptional activation mediated by the SMAD4 complex in the context of TGF-beta signaling. Additionally, it inhibits EP300-mediated acetylation of histone H3 at 'Lys-9'.
Pfam PF11135: Protein of unknown function (DUF2888) (family)
Some members in this family of proteins with unknown function are annotated as immediate early protein ICP-18 however this cannot be confirmed.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF07388: Alpha-2,8-polysialyltransferase (POLYST) (family)
This family contains the bacterial enzyme alpha-2,8-polysialyltransferase ([ec:2.4.99.-]) (approximately 500 residues long). This catalyses the polycondensation of alpha-2,8-linked sialic acid required for the synthesis of polysialic acid (PSA).
Pfam PF12075: KN motif (conserved_site)
This small motif is found at the N-terminus of Kank proteins and has been called the KN (for Kank N-terminal) motif. This protein is found in eukaryotes. Proteins in this family are typically between 413 to 1202 amino acids in length. This protein is found associated with [pfam:PF00023]. This protein has two conserved sequence motifs: TPYG and LDLDF. Kank1 was obtained by positional cloning of a tumor suppressor gene in renal cell carcinoma, while the other members were found by homology search. The family is involved in the regulation of actin polymerization and cell motility through signaling pathways containing PI3K/Akt and/or unidentified modulators/effectors.
Pfam PF01251: Ribosomal protein S7e (family)
A number of eukaryotic ribosomal proteins can be grouped on the basis of sequence similarities . This entry represents the small ribosomal subunit protein eS7 (also referred to as S7) . These proteins have about 200 amino acids.
Ribosomes are the particles that catalyse mRNA-directed protein synthesis in all organisms. The codons of the mRNA are exposed on the ribosome to allow tRNA binding. This leads to the incorporation of amino acids into the growing polypeptide chain in accordance with the genetic information. Incoming amino acid monomers enter the ribosomal A site in the form of aminoacyl-tRNAs complexed with elongation factor Tu (EF-Tu) and GTP. The growing polypeptide chain, situated in the P site as peptidyl-tRNA, is then transferred to aminoacyl-tRNA and the new peptidyl-tRNA, extended by one residue, is translocated to the P site with the aid the elongation factor G (EF-G) and GTP as the deacylated tRNA is released from the ribosome through one or more exit sites . About 2/3 of the mass of the ribosome consists of RNA and 1/3 of protein. The proteins are named in accordance with the subunit of the ribosome which they belong to the small (S1 to S31) and the large (L1 to L44). Usually they decorate the rRNA cores of the subunits.

Many ribosomal proteins, particularly those of the large subunit, are composed of a globular, surfaced-exposed domain with long finger-like projections that extend into the rRNA core to stabilise its structure. Most of the proteins interact with multiple RNA elements, often from different domains. In the large subunit, about 1/3 of the 23S rRNA nucleotides are at least in van der Waal's contact with protein, and L22 interacts with all six domains of the 23S rRNA. Proteins S4 and S7, which initiate assembly of the 16S rRNA, are located at junctions of five and four RNA helices, respectively. In this way proteins serve to organise and stabilise the rRNA tertiary structure. While the crucial activities of decoding and peptide transfer are RNA based, proteins play an active role in functions that may have evolved to streamline the process of protein synthesis. In addition to their function in the ribosome, many ribosomal proteins have some function 'outside' the ribosome .
Pfam PF13476: AAA domain (domain)
This entry represents the AAA domain found in some DNA repair proteins, such as Rad50, SbcC, RecF, RecN and structural maintenance of chromosomes proteins 5 and 6 (Smc5-Smc6) .
AAA ATPases belong to the AAA+ superfamily of ringshaped P-loop NTPases, which exert their activity through the energy-dependent unfolding of macromolecules .
Wikipedia: AAA proteins are a large group of protein family sharing a common conserved module of approximately 230 amino acid residues. This is a large, functionally diverse protein family belonging to the AAA+ protein superfamily of ring-shaped P-loop NTPases, which exert their activity through the energy-dependent remodeling or translocation of macromolecules.
Pfam PF24750: F-box protein At3g26010-like, beta-propeller (repeat)
This entry represents the C-terminal beta propeller domain of F-box protein At3g26010 from Arabidopsis thaliana and similar plant proteins. Members of this family contain an F-box domain ([pfam:PF00646]).
Pfam PF24181: TTI1 C-terminal TPR domain (repeat)
This entry represents the TPR domain found at the C-terminal of TELO2-interacting protein 1 homologue (TTI1) from animals and yeast. TTI1 binds to TELO2 and TTI2 proteins to form the TTT complex, which plays a role in the assembly and stability of all phosphatidylinositol 3-kinase-related protein kinases (PIKKs), pivotal proteins in various pathways related to cell metabolism, proliferation and differentiation. This domain binds to HEAT repeats of the ATM PIKK.
Pfam PF02248: Small coat protein (domain)
This family contains the small coat protein (SCP) of the comoviridae viral family.
Pfam PF10477: Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E (family)
EIF4E-T is the transporter protein for shuttling the mRNA cap-binding protein EIF4E protein, targeting it for nuclear import. EIF4E-T contains several key binding domains including two functional leucine-rich NESs (nuclear export signals) between residues 438-447 and 613-638 in the human protein. The other two binding domains are an EIF4E-binding site, between residues 27-42 in Q9EST3, and a bipartite NLS (nuclear localisation signals) between 194-211, and these lie in family EIF4E-T_N. EIF4E is the eukaryotic translation initiation factor 4E that is the rate-limiting factor for cap-dependent translation initiation.
Pfam PF13660: Domain of unknown function (DUF4147) (domain)
This domain is frequently found at the N-terminus of proteins carrying the glycerate kinase-like domain MOFRL, [pfam:PF05161].
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF24455: Family of unknown function (DUF7571) (family)
This entry represents a small family of uncharacterised proteins found mainly in Halobacteria. They contain four pairs of conserved cysteines that are likely involved in metal coordination.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF23119: Telomerase reverse transcriptase, CTE domain (domain)
This is the CTE (C-terminal element) domain of Telomerase reverse transcriptase from Tetrahymena thermophila (TERT), the catalytic component of the telomerase. This domain adopts a predominantly alpha-helical structure.
Pfam PF19183: Family of unknown function (DUF5865) (family)
This is a family of uncharacterised proteins of unknown function predominantly found in viruses.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF14373: Superinfection immunity protein (family)
This family includes the E. coli bacteriophage T4 superinfection immunity (imm) protein, [swissprot:P08986]. When E. coli is sequentially infected with two T-even type bacteriophage the DNA of the superinfecting phage is excluded from the host, into the periplasmic space. The immunity protein plays a role in this process.
Pfam PF16080: Bacteriophage holin family HP1 (family)
Phage_holin_2_3 is a family of small hydrophobic phage proteins called holins with one transmembrane domain. Holins are produced by double-stranded DNA bacteriophages that use an endolysin-holin strategy to achieve lysis of their hosts. The endolysins are peptidoglycan-degrading enzymes that are usually accumulated in the cytosol until access to the cell wall substrate is provided by the holin membrane lesion 1,2].
Pfam PF20942: Domain of unknown function (DUF4785) central domain (domain)
This family of proteins is found in bacteria. Proteins in this family are typically between 392 and 442 amino acids in length. This entry represents the central immunoglobulin-like domain.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF18809: phage-Barnase-EndoU-ColicinE5/D-RelE like nuclease1 (domain)
A predicted endoRNase of the Barnase-EndoU-ColicinE5/D-RelE like nuclease fold found in polyvalent proteins of phages and conjugative elements. The predicted active site contains a conserved histidine and threonine residues.
Pfam PF04587: ADP-specific Phosphofructokinase/Glucokinase conserved region (family)
In archaea a novel type of glycolytic pathway exists that is deviant from the classical Embden-Meyerhof pathway. This pathway utilises two novel proteins: an ADP-dependent Glucokinase and an ADP-dependent Phosphofructokinase.  This conserved region is present at the C-terminal of both these proteins.  Interestingly this family contains sequences from higher eukaryotes..
Pfam PF16611: Unstructured region between RBD and GoLoco (disordered)
RGs12_us2 is a region of Regulator of G-protein signalling 12 proteins that is natively unstructured and lies between an RBD domain and a GoLoco motif, [pfam:PF02196] and [pfam:PF02188].  The function is not known.
Pfam PF11069: Cilia- and flagella-associated protein 298 (family)
This is a eukaryotic family of proteins which includes a group of cilia- and flagella-associated protein, including Kur from zebrafish and C21orf59 from humans. Kur has been shown to play a dual role in cilia motility and polarization. Primary ciliary dyskinesia (PCD) is caused when defects of motile cilia lead to chronic airway infections, male infertility, and situs abnormalities. Mutations in the C21orf59 gene cause ciliary dyskinesia, primary, 26 (CILD26).