SII-SWORD/CoKE huggingface dataset:
Pfam PF20169: Family of unknown function (DUF6537) (domain)
This entry represents a presumed domain that is found associated with a variety of enzyme domains. The function of this domain is unknown.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF01901: Putative O-antigen polymerase (family)
Archaebacterial proteins of unknown function. Members of this family may be transmembrane proteins. These are potentially O-antigen assembly enzymes, with up to 11 transmembrane regions.
Pfam PF06371: Diaphanous GTPase-binding Domain (repeat)
This domain is bound to by GTP-attached Rho proteins, leading to activation of the Drf protein.
Wikipedia: Formins (formin homology proteins) are a group of proteins that are involved in the polymerization of actin and associate with the fast-growing end (barbed end) of actin filaments. Most formins are Rho-GTPase effector proteins. Formins regulate the actin and microtubule cytoskeleton 
 and are involved in various cellular functions such as cell polarity, cytokinesis, cell migration and SRF transcriptional activity. Formins are multidomain proteins that interact with diverse signalling molecules and cytoskeletal proteins, although some formins have been assigned functions within the nucleus.
Pfam PF00272: Cecropin family (family)
Cecropins  are potent antibacterial proteins that constitute a main part of the cell-free immunity of insects. Cecropins are small proteins of about 35 amino acid residues active against both Gram-positive and Gram-negative bacteria. They seem to exert a lytic action on bacterial membranes. Cecropins have been given various names, including bactericidin, lepidopteran and sarcotoxin. All of these peptides are structurally related.
This entry also includes the antibacterial protein andropin. The andropin gene is closely linked to the cecropin gene cluster of Drosophila melanogaster .
Wikipedia: Cecropins are antimicrobial peptides. They were first isolated from the hemolymph of Hyalophora cecropia, whence the term cecropin was derived. Cecropins lyse bacterial cell membranes; they also inhibit proline uptake and cause leaky membranes.
Pfam PF16160: Domain of unknown function (DUF4866) (family)
This family consists of uncharacterized proteins around 250 residues in length and is mainly found in various human gut Firmicute species and abundant in human gut metagenomic datasets.  The function of this family is unknown.
Pfam PF16465: Domain of unknown function (DUF5046) (repeat)
This small family consists of C-terminal of several uncharacterized proteins around 500 residues in length and is mainly found in various Faecalibacterium species. The function of this family is unknown. This family has distant similarity to WD40 repeats.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF09699: Doubled CXXCH motif (Paired_CXXCH_1) (domain)
This entry represents a domain of about 41 amino acids that contains, among other motifs, two copies of the motif CXXCH associated with haem binding. This domain is predicted to be a high molecular weight c-type cytochrome and is often found in multiple copies. Members are found mostly in species of Shewanella, Geobacter, and Vibrio.
Pfam PF18751: P-loop Nucleotide Kinase3 (family)
A P-loop Nucleotide Kinase predicted to be involved in modified base biosynthesis.
Pfam PF24326: Domain of unknown function (DUF7496) (domain)
This domain is found in a group of uncharacterised eukaryotic proteins. It is predicted to fold into Ig-like beta-sandwich.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF05560: Bacillus thuringiensis P21 molecular chaperone protein (family)
This family contains several Bacillus thuringiensis P21 proteins. These proteins are thought to be molecular chaperones and have mosquitocidal properties.
Pfam PF20467: MmeI, C-terminal domain (domain)
Type IIL Restriction-Modification Enzyme MmeI is a large enzyme that integrates DNA recognition and methyltransferase and endonuclease activities within the same polypeptide. MmeI is composed of five domains. An N-terminal endonuclease domain (residues 1-155), connects to a DNA-methyltransferase domain (MTase, residues  301-320) via a multi-helical spacer (residues 156-300).  These are followed by the target recognition domain (TRD, residues 621-825), and a final C-terminal helical bundle (residues 826-919). The DNA is embedded between the TRD and the MTase domain. The TRD makes contacts to the DNA bases primarily in the major groove, while the MTase domain makes several contacts to the DNA in the minor groove. This domain corresponds to the C-terminal region.
Pfam PF03942: DTW domain (domain)
This presumed domain is found in bacterial and eukaryotic proteins.  Its function is unknown. The domain contains multiple conserved motifs including a DTXW motif that this domain has been named after.
Pfam PF20413: BLTP1-like family N-terminal region (repeat)
This entry represents the N-terminal region of a group of very long eukaryotic proteins, including the human BLTP1 (also known as KIAA1109) protein. These proteins are tube-forming lipid transport proteins that belong to the RBG (repeating beta-groove) superfamily. They consist of long hydrophobic grooves made of multiple repeating modules of five beta-sheets followed by a loop. BLTP1 is a tube-forming lipid transport protein which provides phosphatidylethanolamine for glycosylphosphatidylinositol (GPI) anchor synthesis in the endoplasmic reticulum. It plays a role in endosomal trafficking and endosome recycling and it is also involved in the actin cytoskeleton and cilia structural dynamics. BLTP1 also acts as a regulator of phagocytosis. In humans, it has been associated with rheumatoid arthritis. Mutations of the BLTP1 gene has been associated with Alkuraya-Kucinskas syndrome (MIM 617822), a severe disorder of brain development and arthrogryposis.
Pfam PF19846: Domain of unknown function (DUF6321) (domain)
This presumed domain is functionally uncharacterised. This domain family is found in bacteria and viruses, and is approximately 80 amino acids in length. It has a conserved sequence GGLxxxGRxxY and a conserved tryptophan residue at the C-terminal.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF03587: EMG1/NEP1 methyltransferase (family)
Members of this family are essential for 40S ribosomal biogenesis.  The structure of EMG1 has revealed that it is a novel member of the superfamily of alpha/beta knot fold methyltransferases.
Pfam PF01925: Sulfite exporter TauE/SafE (family)
This is a family of integral membrane proteins where the alignment appears to contain two duplicated modules of three transmembrane helices. The proteins are involved in the transport of anions across the cytoplasmic membrane during taurine metabolism as an exporter of sulfoacetate. This family used to be known as DUF81.
Pfam PF00349: Hexokinase (domain)
Hexokinase ([ec:2.7.1.1]) contains two structurally similar domains represented by this family and [pfam:PF03727].  Some members of the family have two copies of each of these domains.
Wikipedia: A hexokinase is an enzyme that irreversibly phosphorylates hexoses, forming hexose phosphate. In most organisms, glucose is the most important substrate for hexokinases, and glucose-6-phosphate is the most important product. Hexokinase possesses the ability to transfer an inorganic phosphate group from ATP to a substrate.
Pfam PF14630: Origin recognition complex (ORC) subunit 5 C-terminus (domain)
This entry represents the C-terminus of origin recognition complex subunit 5, which consists of a winged helix domain (WHD).
Wikipedia: Origin recognition complex subunit 5 is a protein that in humans is encoded by the ORC5 (ORC5L) gene.
Pfam PF06283: Trehalose utilisation (domain)
This family consists of several bacterial ThuA-like proteins. ThuA appears to be involved in utilisation of trehalose. The thuA and thuB genes form part of the trehalose/sucrose transport operon thuEFGKAB, which is located on the pSymB megaplasmid. The thuA and thuB genes are induced in vitro by trehalose but not by sucrose and the extent of its induction depends on the concentration of trehalose available in the medium. ThuA is involved in the conversion of of disaccharides to their respective 3-keto derivatives.
Pfam PF20610: Thioester domain (domain)
This domain is related to the TED domain [pfam:PF08341].
Pfam PF15123: Domain of unknown function (DUF4562) (family)
This family of proteins is functionally uncharacterised. This family of proteins is found in eukaryotes. There is a conserved HRYQNPW sequence motif. This family includes the human protein C4orf45.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF00423: Haemagglutinin-neuraminidase (repeat)
This entry represents the haemagglutinin-neuraminidase (HN) glycoprotein found in a variety of paramyxoviruses (negative-stranded RNA viruses), including Mumps virus, Human parainfluenza virus 3, and the avian pathogen Newcastle disease virus. It also includes hemagglutinin glycoproteins from Morbiliviruses, a genus belonging to the Paramyxoviridae family that includes the Measles virus. Morbiliviruses hemagglutinins have no neuraminidase activity .

HN is a multi-functional protein with three distinct functions: a receptor-binding (haemagglutinin) activity, a receptor-destroying (neuraminidase) activity, and a membrane fusion activity that fuses the viral envelope to the host cell membrane in order to infect the cell.
Wikipedia: Hemagglutinin-neuraminidase refers to a single viral protein that has both hemagglutinin and (endo) neuraminidase EC 3.2.1.18 activity. This is in contrast to the proteins found in influenza, where both functions exist but in two separate proteins. Its neuraminidase domain has the CAZy designation glycoside hydrolase family 83 (GH83).
Pfam PF14339: Domain of unknown function (DUF4394) (repeat)
This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 262 and 476 amino acids in length.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF21619: Family of unknown function (DUF6855) (domain)
This single domain protein is found a range of bacteria such as actinobacteria, bacteroidetes and firmicutes. It is functionally uncharacterised. The proteins are about 130 amino acids in length.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF01858: Retinoblastoma-associated protein A domain (domain)
This domain has the cyclin fold as predicted.
Pfam PF07514: Putative helicase (family)
Some members of this family have been annotated as helicases.
Pfam PF15548: Domain of unknown function (DUF4655) (disordered)
This family of proteins is found in eukaryotes. Proteins in this family are typically between 533 and 570 amino acids in length.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF10209: Uncharacterized conserved protein (DUF2340) (family)
This is a family of small proteins of approximately 150 amino acids of unknown function.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF02760: HIN-200/IF120x domain (family)
This domain is found in one or two copies per protein, and is found associated with the PAAD/DAPIN domain [pfam:PF02758]. This domain recognises and interacts with the phosphate backbone of dsDNA in a sequence-independent manner.
Pfam PF18615: Short myomegalin-like EB1 binding proteins, N-terminal domain (family)
This N-terminal region is found in SMYLE (for short myomegalin-like EB1 binding protein). It does not include the SMYLE homology (SmyH) domain found in the first 100 residues at the N terminus. The conserved SmyH domain is required and sufficient for PKA scaffolding protein AKAP9, and the pericentrosomal protein CDK5RAP2 binding.
Pfam PF20961: Bacteriophage phiKZ, gp29PR (family)
This domain is found in the Tail sheath protein gp29 from the giant Bacteriophage phiKZ. This entry represents a protease resistant fragment of this protein, gp29PR, which consists of a single domain showing a seven-stranded beta-sandwich with long insertions connecting adjacent beta-strands, including a long alpha-helix.
Pfam PF11723: Homotrimeric ring hydroxylase (domain)
This domain is found on aromatic hydroxylating enzymes such as 2-oxo-1,2-dihydroquinoline 8-monooxygenase from Pseudomonas putida and carbazole 1,9a-dioxygenase from Janthinobacterium. These enzymes are homotrimers and are distantly related to the typical oxygenase.  This domain is found C terminal to the Rieske domain which binds an iron-sulphur cluster.
Pfam PF11969: Scavenger mRNA decapping enzyme C-term binding (family)
This family consists of several scavenger mRNA decapping enzymes (DcpS) and is the C-terminal region. DcpS is a scavenger pyrophosphatase that hydrolyses the residual cap structure following 3' to 5' decay of an mRNA. The association of DcpS with 3' to 5' exonuclease exosome components suggests that these two activities are linked and there is a coupled exonucleolytic decay-dependent decapping pathway. The C-terminal domain contains a histidine triad (HIT) sequence with three histidines separated by hydrophobic residues. The central histidine within the DcpS HIT motif is critical for decapping activity and defines the HIT motif as a new mRNA decapping domain, making DcpS the first member of the HIT family of proteins with a defined biological function.
Wikipedia: Scavenger mRNA-decapping enzyme DcpS is a protein that in humans is encoded by the DCPS gene.
Pfam PF23475: FmdE treble clef zinc finger (domain)
This treble clef zinc finger is found C-terminal in some members of FmdE family that are implicated in microbial methanogenesis. This domain follows the alpha/beta core domain ([pfam:PF02663]) and contains four invariant cysteine residues that coordinate the zinc atom.
Pfam PF23542: Domain of unknown function (DUF1512) C-terminal (domain)
This family consists of several archaeal proteins of around 370 residues in length. This entry corresponds to the C-terminal domain.  The function of this family is unknown. This domain shows structural similarity to peptidyl tRNA hydrolase enzymes.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF14977: FAM194 protein (family)
This family is found in eukaryotes, and is approximately 210 amino acids in length. There is a conserved YPSG sequence motif. The function of this family is unknown.
Pfam PF21264: Cytoplasmic dynein 2 heavy chain 1, AAA+ ATPase domain (domain)
This domain is found in Cytoplasmic dynein 2 heavy chain 1 from humans (DYNC2H1) and similar sequences from eukaryotes. Dynein-2 is essential for the dynamic remodelling of the ciliary proteome and is associated with human skeletal ciliopathies. DYNC2H1, one of its specific components, is the motor-domain- containing heavy chain. This protein consists of a compact N-terminal region, an elongated tail and a C-terminal AAA+ motor domain. There are two copies of this protein in the complex, each adopting a different configuration, which contributes to the asymmetry of Dynein-2. This entry covers one of the six motor's ring AAA+ domains (ATPases associated with various cellular activities).
Pfam PF12408: Ribose-5-phosphate isomerase (family)
This domain family is found in bacteria, and is approximately 50 amino acids in length. The family is found in association with [pfam:PF02502]. There are two completely conserved residues (D and F) that may be functionally important.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF04025: Extracellular matrix regulatory protein A-like (family)
This family of mostly uncharacterised proteins includes the extracellular matrix regulatory protein A (RemA) from Bacillus subtilis. RemA is required for biosynthesis of the extracellular matrix and biofilm formation. It binds to DNA at multiple sites upstream of the promoters of the operons eps and tapA-sipW-tasA, which are required for the synthesis of the extracellular matrix components, extracellular polysaccharide and TasA amyloid proteins. SinR negatively regulates eps operon expression by occluding RemA binding. Structure of RemA homologue from Geobacillus thermodenitrificans revealed that it forms an unique octameric ring with the potential to form a 16-meric superstructure and suggests that RemA can wrap DNA around its ring-like structure.
Pfam PF06628: Catalase-related immune-responsive (family)
This family represents a small conserved region within catalase enzymes ([ec:1.11.1.6]). All members also contain the Catalase family, [pfam:PF00199] domain. Catalase decomposes hydrogen peroxide into water and oxygen, serving to protect cells from its toxic effects. This domain carries the immune-responsive amphipathic octa-peptide that is recognised by T cells.
Wikipedia: In molecular biology, the catalase-related immune-responsive domain is a protein domain found in catalases. This domain carries the immune-responsive amphipathic octa-peptide that is recognised by T cells.
Pfam PF08902: Domain of unknown function (DUF1848) (family)
This family of proteins are functionally uncharacterised. The C-terminus contains a cluster of cysteines that are similar to the iron-sulfur cluster found at the N-terminus of [pfam:PF04055].
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF18539: Domain of unknown function (DUF5625) (domain)
This is a domain of unknown function found in proteobacteria.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF12433: Parvovirus non-structural protein 1 (family)
This family of proteins is found in viruses. Proteins in this family are typically between 109 and 668 amino acids in length. Parvoviral NSPs regulate host gene expression through histone acetylation.
Pfam PF15268: Dapper (disordered)
This is a family of signalling proteins. They act in a diverse range of signaling pathways and have a range of binding partners. They act as homo- and heterodimers.
Pfam PF20752: Structural protein 2 C-terminal domain (domain)
This entry represents the third domain of structural protein 2 of the hepatitis E virus. This domain has a RIFT-like fold. The high basic amino acid content of this protein has lead to the suggestion of a role in viral genomic RNA encapsidation.
Pfam PF24032: YQBQ-like (domain)
This entry represents a domain found standalone in the Uncharacterized protein YqbQ, Phage-like element PBSX protein XkdQ and other related proteins. This domain is also found N-terminal in Clostridioides difficile endolysin (Ecd09610). It is predicted to adopt a globular structure comprised mainly of two beta-barrels arranged in a head-to-tail manner. The function of this domain is unknown.