SII-SWORD/CoKE huggingface dataset:
Pfam PF08709: Inositol 1,4,5-trisphosphate/ryanodine receptor (domain)
This domain corresponds to the ligand binding region on inositol 1,4,5-trisphosphate receptor, and the N terminal region of the ryanodine receptor.  Both receptors are involved in Ca2+ release. They can couple to the activation of neurotransmitter-gated receptors and voltage-gated Ca2+ channels on the plasma membrane, thus allowing the endoplasmic reticulum discriminate between different types of neuronal activity.
Pfam PF07124: Phytoreovirus outer capsid protein P8 (family)
This family consists of several Phytoreovirus outer capsid protein P8 sequences.
Pfam PF07374: Protein of unknown function (DUF1492) (family)
This family consists of several hypothetical, highly conserved Streptococcal and related phage proteins of around 100 residues in length.  The function of this family is unknown. It appears to be distantly related to [pfam:PF08281].
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF02837: Glycosyl hydrolases family 2, sugar binding domain (domain)
This family contains beta-galactosidase, beta-mannosidase and beta-glucuronidase activities and has a jelly-roll fold. The domain binds the sugar moiety during the sugar-hydrolysis reaction.
Wikipedia: In molecular biology, Glycoside hydrolase family 2 is a family of glycoside hydrolases EC 3.2.1., which are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycoside hydrolases, based on sequence similarity, has led to the definition of &gt;100 different families. This classification is available on the CAZy web site, and also discussed at CAZypedia, an online encyclopedia of carbohydrate active enzymes.
Pfam PF25039: BLTP1-like family middle region (repeat)
This entry represents the middle region of a group of very long eukaryotic proteins, including the human BLTP1 (also known as KIAA1109) protein. These proteins are tube-forming lipid transport proteins that belong to the RBG (repeating beta-groove) superfamily. They consist of long hydrophobic grooves made of multiple repeating modules of five beta-sheets followed by a loop. BLTP1 is a tube-forming lipid transport protein which provides phosphatidylethanolamine for glycosylphosphatidylinositol (GPI) anchor synthesis in the endoplasmic reticulum. It plays a role in endosomal trafficking and endosome recycling and it is also involved in the actin cytoskeleton and cilia structural dynamics. BLTP1 also acts as a regulator of phagocytosis. In humans, it has been associated with rheumatoid arthritis. Mutations of the BLTP1 gene has been associated with Alkuraya-Kucinskas syndrome (MIM 617822), a severe disorder of brain development and arthrogryposis.
Pfam PF12033: Protein of unknown function (DUF3519) (family)
This family of proteins is functionally uncharacterised. This protein is found in bacteria. Proteins in this family are typically between 117 to 1154 amino acids in length. This protein has a single completely conserved residue Q that may be functionally important.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF16322: Tubby N-terminal (family)
Tub_N is the N-terminal region of Tubby proteins. It carries a nuclear localisation signal and is able to activate transcription.
Pfam PF23535: Apicomplexa microprotein (family)
This protein family includes uncharacterised microproteins encoded by small open reading frames (smORFs) from apicomplexa, including [swissprot:A7AU56] from the parasite Babesia bovis.
Pfam PF14945: Normal lung function maintenance, Low in Lung Cancer 1 protein (family)
This protein is part of a family found in eukaryotes. It is 137 amino acids long in protein sequence length and mass is approximately 15.7 kDa. The protein is present in the normal lung epithelium, but absent or downregulated in most primary non-small lung cancers. The gene is known as Low in Lung Cancer 1 (LLC1). This protein is thought to have a role in the maintenance of normal lung function and its absence may lead to lung tumourigenesis.
Pfam PF24432: Family of unknown function (DUF7555) (family)
This entry represents a small family of uncharacterised proteins found in Halobacteria. These proteins are likely associated with the membrane. They are predicted to fold into a three helical bundle.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF22565: Minimal SLOG domain (domain)
This entry represents a domain predicted to be an active, minimal version of the SLOG domain. It is found N-terminally fused to the DUF4326 domain ([pfam:PF14216]). It may play a role in base cleavage, potentially forming abasic sites acted on by DuOB domain ([pfam:PF22557]).
Pfam PF14179: YppG-like protein (family)
The YppG-like protein family includes the B. subtilis YppG protein [swissprot:P50835], which is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 115 and 181 amino acids in length. There are two completely conserved residues (F and G) that may be functionally important.
Pfam PF13215: Protein of unknown function (DUF4023) (family)
This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 40 amino acids in length. There is a conserved KLP sequence motif.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF18324: Bacterial isocitrate dehydrogenase, C-terminal domain (domain)
This domain is found at the C-terminal end of Isocitrate dehydrogenase [NADP] from Rickettsia typhi and similar bacterial proteins. It is also found in  the hypothetical protein TT1725 from Thermus thermophilus HB8. The presence of positively-charged residues in the alpha-1 helix suggests this region binds to a protein with a negatively charged region or to nucleic acids.
Pfam PF09004: Alkylated DNA repair protein alkB homolog 8, N-terminal (domain)
This domain is the N-terminal domain of Alkylated DNA repair protein alkB homolog 8 (ALKBH8) and its homologues. This domain corresponds to the basic alpha-helix located at the N-terminal of the RRM domain, which enhances its RNA binding affinity.
Pfam PF15769: Domain of unknown function (DUF4698) (family)
This family of proteins is found in eukaryotes. Proteins in this family are typically between 464 and 550 amino acids in length.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF23918: Domain of unknown function (DUF7257) (domain)
This entry represents a phage protein which contains a C1q and TNF superfamily domain. Structure prediction suggests that this domain forms a confident homotrimeric interaction.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF16230: Domain of unknown function (DUF4889) (family)
This family consists of uncharacterized proteins  around 110 residues in length and is mainly found in  various Staphylococcus aureus species. The function  of this family is unknown.
Pfam PF20140: Family of unknown function (DUF6530) (family)
This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 160 amino acids in length.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF12990: Domain of unknonw function from B. Theta Gene description (DUF3874) (family)
Based on Bacteroides thetaiotaomicron gene BT_4228, a putative uncharacterized protein  As seen in gene expression experiments (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE2231), It appears to be upregulated in the presence of host or other bacterial species vs when in culture.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF01546: Peptidase family M20/M25/M40 (family)
This family includes a range of zinc metallopeptidases belonging to several families in the peptidase classification. Family M20 are Glutamate carboxypeptidases.  Peptidase family M25 contains X-His dipeptidases.
Pfam PF09314: Domain of unknown function (DUF1972) (family)
Members of this family of functionally uncharacterised domains are found in bacterial glycosyltransferases and rhamnosyltransferases.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF03755: Endoribonuclease YicC-like, N-terminal region (domain)
This domain is found at the N-terminal end of Endoribonuclease YicC from Escherichia coli and similar bacterial sequences. YicC, which is important for cells in the stationary phase, and essential for growth at high temperatures, contributes to degradation of the small RNA (sRNA) RhyB via collaboration with the exoribonuclease PNPase and seems to generate a 3'-OH and a 5'-phosphate group.
Pfam PF03229: Alphavirus glycoprotein J (family)
The exact function of the herpesvirus glycoprotein J is unknown, but it appears to play a role in the inhibition of apotosis of the host cell .
Pfam PF10103: Zincin-like metallopeptidase (family)
This family of proteins has a conserved HEXXH motif, suggesting they are putative peptidases of zincin fold. The structure of this family has similarity to Peptidase_M1 ([pfam:PF01433], PDB:3CMN).
Pfam PF09925: Predicted membrane protein (DUF2157) (family)
This domain, found in various hypothetical prokaryotic proteins, has no known function.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF02281: Transposase Tn5 dimerisation domain (domain)
Transposons are mobile DNA sequences capable of replication and insertion into the chromosome. Typically transposons code for the transposase enzyme, which catalyses insertion, found between terminal inverted repeats. Tn5 has a unique method of self- regulation in which a truncated version of the transposase enzyme acts as an inhibitor. The catalytic domain of the Tn5 transposon is found in [pfam:PF01609].  This domain mediates dimerisation in the known structure.
Wikipedia: A transposase is any of a class of enzymes capable of binding to the end of a transposon and catalysing its movement to another part of a genome, typically by a cut-and-paste mechanism or a replicative mechanism, in a process known as transposition. The word "transposase" was first coined by the individuals who cloned the enzyme required for transposition of the Tn3 transposon. The existence of transposons was postulated in the late 1940s by Barbara McClintock, who was studying the inheritance of maize, but the actual molecular basis for transposition was described by later groups. McClintock discovered that some segments of chromosomes changed their position, jumping between different loci or from one chromosome to another. The repositioning of these transposons allowed other genes for pigment to be expressed. Transposition in maize causes changes in color; however, in other organisms, such as bacteria, it can cause antibiotic resistance. Transposition is also important in creating genetic diversity within species and generating adaptability to changing living conditions.
Pfam PF21757: Family of unknown function (DUF6870) (domain)
This entry represents a small bacterial protein o unknown function. Proteins in this family are primarily found in Firmicutes.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF00800: Prephenate dehydratase (family)
This protein is involved in Phenylalanine biosynthesis. This protein catalyses the decarboxylation of prephenate to phenylpyruvate.
Pfam PF23224: Zinc finger protein 462, second C2H2 zinc finger (domain)
This domain is found in the human Zinc finger protein 462 and related proteins. This protein is involved in transcription by regulating chromatin structure and organisation. ZNF462 is a multidomain protein that contains a number of classical C2H2 zinc fingers. This entry represents one of them.
Pfam PF23746: Tail assembly protein gp41 (family)
This entry includes the probable tail assembly protein gp41 from Bacteriophage Mu (Mup41 and FS-gp41) and Mu-like prophage FluMu protein gp41 from H. influenzae. Mup41 and FS-gp41 may act as a chaperone mediating the interaction between the tape measure protein (TMP) and the tail tube protein (TTP) thereby directing the polymerization of TTP to form a tail of the correct length.
Pfam PF18970: Family of unknown function (DUF5709) (disordered)
The function of this domain is not clear.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF11853: Protein of unknown function (DUF3373) (family)
This family of proteins are functionally uncharacterised. This protein is found in bacteria. Proteins in this family are typically between 472 to 574 amino acids in length.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF17823: Family of unknown function (DUF5585) (family)
This is a family of unknown function found in chordata.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF24189: RSC4 Ig-like domain (domain)
This entry represents the C-terminal Ig-like domain of RSC4 from S.cerevisiae and closely related sequences which are not matched by [pfam:PF22994] as this domain has a long insertion not present in its homologue from S.pombe. RSC4 is a component of the chromatin structure remodeling complex (RSC), which is involved in transcription regulation and nucleosome positioning. This C-terminal region mediates assembly into the RSC complex and seems to be required for cell growth.
Pfam PF17002: Domain of unknown function (DUF5089) (family)
This is a family of microsporidial-specific proteins of unknown function. There is distant homology to synaptosomal-associated 25 family proteins.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF05904: Plant protein of unknown function (DUF863) (family)
This family consists of a number of hypothetical proteins from Arabidopsis thaliana and Oryza sativa. The function of this family is unknown.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF20747: Lactophage receptor-binding protein N-terminal shoulder domain (domain)
Caudo_bapla_RBP is a family of proteins expressed from ORF18 of the Lactococcus P2-like phage. This is one of three protein domain, shoulder, neck, and head, that form the phage tail base-plate. This entry represents the shoulder domain. This domain contains a beta sandwich fold.
Pfam PF24453: Family of unknown function (DUF7569) (family)
This entry represents a small family of uncharacterised proteins found mainly in Halobacteria. They contain two pairs of conserved cysteines that are likely involved in metal coordination. These proteins are predicted to structurally resemble treble-clef zinc fingers.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF13488: Glycine zipper (domain)
This entry represents a glycine zipper domain.
Pfam PF11352: Protein of unknown function (DUF3155) (family)
This family of proteins with unknown function appears to be restricted to Cyanobacteria.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF13865: C-terminal duplication domain of Friend of PRMT1 (family)
Fop, or Friend of Prmt1, proteins are conserved from fungi and plants to vertebrates. There is little that is actually conserved except for this C-terminal LDXXLDAYM region where X is any amino acid). The Fop proteins themselves are nuclear proteins localised to regions with low levels of DAPI, with a punctate/speckle-like distribution. Fop is a chromatin-associated protein and it co-localises with facultative heterochromatin. It is is critical for oestrogen-dependent gene activation.
Pfam PF21701: Glyoxalasedomain-containing protein 4-like, C-terminal domain (domain)
This domain is found at the C-terminal end of Glyoxalase domain- containing protein 4 from humans (GLOD4) and similar eukaryotic sequences. This group includes structurally related proteins that provide a metal coordination environment to promote direct electrophilic participation of the metal ion in catalysis. This domain shows an alpha-beta structure.
Pfam PF02673: Bacitracin resistance protein BacA (family)
Bacitracin resistance protein (BacA) is a putative undecaprenol kinase. BacA confers resistance to bacitracin, probably by phosphorylation of undecaprenol. More recent studies show that BacA has undecaprenyl pyrophosphate phosphatase activity. Undecaprenyl phosphate is a key lipid intermediate involved in the synthesis of various bacterial cell wall polymers. Bacitracin, a mixture of related cyclic polypeptide antibiotics, is used to treat surface tissue infections. Its primary mode of action is the inhibition of bacterial cell wall synthesis through sequestration of the essential carrier lipid undecaprenyl pyrophosphate, C55-PP, resulting in the loss of cell integrity and lysis. The characteristic phosphatase sequence-motif in this family is likely to be the PGxSRSGG, compared with the PSGH of the PAP family of phosphatases.
Wikipedia: In enzymology, an undecaprenyl-diphosphatase (EC 3.6.1.27) is an enzyme that catalyzes the chemical reactionundecaprenyl diphosphate + H2O  undecaprenyl phosphate + phosphate