SII-SWORD/CoKE huggingface dataset:
Pfam PF02270: TFIIF, beta subunit HTH domain (domain)
Accurate transcription in vivo requires at least six  general transcription initiation factors, in addition to RNA  polymerase II. Transcription initiation factor IIF (TFIIF) is a tetramer of two beta subunits associate with two alpha subunits which interacts directly with RNA polymerase II. The beta subunit  of TFIIF is required for recruitment of RNA polymerase II onto  the promoter.
Pfam PF07957: Protein of unknown function (DUF3294) (family)
This family was annotated as mitochondrial Ribosomal protein MRP8, based on the presumed similarity of the S.cerevisiae protein to an E.coli mitochondrial ribosomal protein; however, this similarity is spurious, and the function is not known [Wood, V].
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF00608: Adenoviral fibre protein (repeat/shaft region) (repeat)
There is no separation between signal and noise. Specific attachment of adenovirus is achieved through interactions between host-cell receptors and the adenovirus fibre protein and is mediated by the globular carboxy-terminal domain of the adenovirus fibre protein, rather than the 'shaft' region represented by this family. The alignment of this family contains two copies of a fifteen residue repeat found in the 'shaft' region of adenoviral fibre proteins.
Pfam PF16046: FAM76 protein (family)
This family of proteins is functionally uncharacterised. This family of proteins is found in eukaryotes. Proteins in this family are typically between 233 and 341 amino acids in length.
Pfam PF14063: Protein of unknown function (DUF4254) (family)
This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and eukaryotes. Proteins in this family are typically between 195 and 207 amino acids in length.
Pfam PF02974: Protease inhibitor Inh (domain)
The Inh inhibitor is secreted into the periplasm where its presumed physiological function is to protect periplasmic proteins against the action of secreted proteases. A range of proteases including A, B and C from E. chrysanthemi, alkaline protease from Pseudomonas aeruginosa and the 50 kDa protease from Serratia marcescens are inhibited.
Pfam PF17028: 8TM Microsporidial transmembrane domain (family)
This is a family of largely microsporidial-specific proteins that carry eight transmembrane regions, in two blocks of four. Such an arrangement of TMs suggests a transporter function of some kind. There is a highly conserved NFLNW sequence-motif at the C-terminus which might be of functional importance.
Pfam PF15282: BMP-2-inducible protein kinase C-terminus (family)
This family represents the C-terminus of BMP2K and related proteins.
Wikipedia: BMP-2-inducible protein kinase is an enzyme in humans encoded by the BMP2K gene.
Pfam PF11843: Protein of unknown function (DUF3363) (family)
This family of proteins are functionally uncharacterised. This protein is found in bacteria. Proteins in this family are typically between 323 to 658 amino acids in length.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF19689: Family of unknown function (DUF6190) (family)
This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0002018) is described by MIBiG as an example of the following biosynthetic class, other (unspecified). It includes a  member from the azomycin biosynthetic gene cluster from Streptomyces cattleya NRRL 8057 = DSM 46488. This family appears to be  predominantly found in bacteria.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF17855: MCM AAA-lid domain (domain)
This entry represents the AAA-lid domain found in MCM proteins.
Wikipedia: The minichromosome maintenance protein complex (MCM) is a DNA helicase essential for genomic DNA replication. Eukaryotic MCM consists of six gene products, Mcm2–7, which form a heterohexamer. As a critical protein for cell division, MCM is also the target of various checkpoint pathways, such as the S-phase entry and S-phase arrest checkpoints. Both the loading and activation of MCM helicase are strictly regulated and are coupled to cell growth cycles. Deregulation of MCM function has been linked to genomic instability and a variety of carcinomas.
Pfam PF24510: TXNDC16 third thioredoxin-like domain (domain)
This is the third thioredoxin-like domain of TXNDC16 proteins, whose function is unknown.
Pfam PF21874: CofJ protein (domain)
This entry describes the CofJ protein family. CofJ is a soluble protein secreted via the CFA/III apparatus in Enterotoxigenic Escherichia coli (ETEC), which colonize the human gut causing severe diarrhoea. CofJ is a single-domain protein of 326 residues, comprised of an elongated beta-sandwich core with three alpha-helices, four 3-10 helices and multiple loops on its surface. The protein has a cluster of exposed hydrophobic side-chains at one end and structural homology to the pore-forming proteins perfringolysin O and alpha-haemolysin. The crystal structure of CofJ was determined, revealing a large beta-sandwich protein that bears no sequence or structural homology to TcpF, a protein encoded by the syntenic gene in the TCP operon of Vibrio cholerae. CofJ binds to lipid vesicles and epithelial cells, suggesting a role in membrane attachment during ETEC colonization.
Pfam PF15554: FSIP1 family (family)
Found in the main part of the sperm flagellum, the fibrous sheath is a cytoskeletal structure comprising two longitudinal columns connected by closely spaced circumferential ribs . A-kinase anchoring proteins (AKAPs) secure cyclic AMP-dependent protein kinases within specific cytoplasmic domains; most abundant in the fibrous sheath is AKAP4 . AKAP4 has been shown to bind AKAP3 and two spermatogenic cell-specific proteins, Fibrous Sheath Interacting Proteins 1 and 2 (FSIP1, FSIP2) .

How the fibrous sheath assembles is not yet fully understood. AKAP4 is synthesised and incorporated into the nascent fibrous sheath late in spermatid development; its precursor is processed in the flagellum, and only the mature form of AKAP4 appears to bind AKAP3 . It is likely, therefore, that AKAP3 is involved in organising the basic structure of the fibrous sheath, while AKAP4 helps to complete fibrous sheath assembly.

The FSIP1 protein is 435 amino acids in length, and is rich in glutamine and asparagine . Minimum domains for its binding to AKAP4 have been localised to amino acids 351-359 and 692-721 of AKAP4 constructs .
Pfam PF24317: Plexin-B, PSI domain (domain)
This entry represents a PSI domain found in Plexin B proteins. These are SEMA4 and SEMA5 receptors that play a role in axon guidance,  invasive growth and cell migration. They play important roles in cell-cell signaling, glutamatergic (Plexin-B2) and GABAergic (Plexin-B1) synapse development and RHOA activation and subsequent changes of the actin cytoskeleton.
Pfam PF15116: CAMPATH-1 antigen (family)
CAMPATH-1 antigen (also known as CD52) is a very small glycosylphosphatidylinositol (GPI)-anchored glycoprotein present in lymphocytes , male reproductive tracts and female cumulus cells . CD52 on the lymphocyte membrane surface induces regulatory T cells with immunosuppressive activities . In the male reproductive tract, CD52 may protect sperm function from complement attack if antisperm antibody is generated in the female reproductive tracts . It has also been suggested that CD52 has some functional roles around fertilisation in females as well as in males .
Wikipedia: CAMPATH-1 antigen, also known as cluster of differentiation 52 (CD52), is a glycoprotein that in humans is encoded by the CD52 gene.
Pfam PF09832: Uncharacterized protein conserved in bacteria (DUF2059) (family)
This domain, found in various prokaryotic proteins, has no known function.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF22793: Domain of unknown function (DUF7013) (domain)
This is a presumed domain found at the N-terminal of phage sequences, which also have a FN3-like domain ([pfam:PF21470]) at the C-terminal.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF04994: TfoX C-terminal domain (domain)
TfoX may play a key role in the development of genetic competence by regulating the expression of late competence-specific genes. This family corresponds to the C-terminal presumed domain of TfoX. The domain is found associated with [pfam:PF00383] in [swissprot:Q9JZR1].  It is also found as an isolated domain in some proteins suggesting this is an autonomous domain.
Pfam PF13407: Periplasmic binding protein domain (family)
This domain is found in a variety of bacterial periplasmic binding proteins. This domain recognises fructose (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).
Pfam PF11341: Protein of unknown function (DUF3143) (family)
This family of proteins has no known function.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF18489: Alpha helical domain (domain)
This is the N-terminal domain found in putative tRNA-binding proteins found in archaea. Structural analysis from Pyrococcus horikoshii indicate that it is a helical domain where many conserved residues are found in the first three helices and are mainly located on the inverse side of the putative tRNA-binding site. A structural homology search suggested that this fold prefers to bind proteins/peptides.
Pfam PF05690: Thiazole biosynthesis protein ThiG (domain)
This family consists of several bacterial thiazole biosynthesis protein G sequences. ThiG , together with ThiF and ThiH, is proposed to be involved in the synthesis of 4-methyl-5-(b-hydroxyethyl)thiazole (THZ) which is an intermediate in the thiazole production pathway. This family also includes  triosephosphate isomerase and pyridoxal 5'-phosphate synthase subunit  PdxS.
Pfam PF18668: Tail spike TSP1/Gp66 receptor binding N-terminal domain (domain)
Bacteriophages recognize and bind to their hosts with the help of receptor-binding proteins (RBPs) that emanate from the phage particle in the form of fibers or tailspikes. RBPs of podovirus G7C tailspikes gp63.1 and gp66 are essential for infection of its natural host bacterium E. coli 4s. Gp63.1 and gp66 form a stable complex, in which the N-terminal part of gp66 serves as an attachment site for gp63.1 and anchors the gp63.1-gp66 complex to the G7C tail. The two N-terminal domains show 70% sequence identity to the N-terminal region of the CBA120 phage tailspike 1 (orf210, TSP1). The N-terminal domain of TSP1 is the virion head binding domain that interfaces with the phage baseplate. The N-terminal domain can be further divided into two subdomains, each beginning with a alpha-helix followed by an anti-parallel beta-sandwich. Subdomain two folds similarly to the chitin binding domain of Chitinase from Bacillus circulans.
Pfam PF08755: Hemimethylated DNA-binding protein YccV like (domain)
YccV is a hemimethylated DNA binding protein which has been shown to regulate dnaA gene expression.  The structure of one of the hypothetical proteins in this family has been solved and it forms a beta sheet structure with a terminating alpha helix.
Wikipedia: In molecular biology, YccV protein domain is also, alternatively named, Heat shock protein HspQ. This entry describes the small protein from Escherichia coli YccV and its homologs in other Pseudomonadota. YccV is now described as a hemimethylated DNA binding protein. The model entry describes a protein domain in longer eukaryotic proteins.
Pfam PF19234: Family of unknown function (DUF5887) (family)
This is a family of uncharacterised proteins of unknown function predominantly found in viruses. This family includes proteins that are thought to have acetyltransferase activity.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF06367: Diaphanous FH3 Domain (repeat)
This region is found in the Formin-like and and diaphanous proteins.
Wikipedia: Formins (formin homology proteins) are a group of proteins that are involved in the polymerization of actin and associate with the fast-growing end (barbed end) of actin filaments. Most formins are Rho-GTPase effector proteins. Formins regulate the actin and microtubule cytoskeleton 
 and are involved in various cellular functions such as cell polarity, cytokinesis, cell migration and SRF transcriptional activity. Formins are multidomain proteins that interact with diverse signalling molecules and cytoskeletal proteins, although some formins have been assigned functions within the nucleus.
Pfam PF08579: Mitochondrial ribonuclease P subunit (RPM2) (repeat)
Ribonuclease P (RNase P) generates mature tRNA molecules by cleaving their 5' ends.  RPM2 is a protein subunit of the yeast mitochondrial RNase P.  It has the ability to act as transcriptional activator in the nucleus where it plays a role in defining the steady-state levels of mRNAs for some nucleus-encoded mitochondrial components.
Pfam PF05198: Translation initiation factor IF-3, N-terminal domain (domain)
Initiation factor 3 (IF-3) (gene infC) is one of the three factors required for the initiation of protein biosynthesis in bacteria. IF-3 is thought to function as a fidelity factor during the assembly of the ternary initiation complex which consist of the 30S ribosomal subunit, the initiator tRNA and the messenger RNA. IF-3 is a basic protein that binds to the 30S ribosomal subunit . The chloroplast initiation factor IF-3(chl) is a protein that enhances the poly(A,U,G)-dependent binding of the initiator tRNA to chloroplast ribosomal 30s subunits in which the central section is evolutionary related to the sequence of bacterial IF-3 .
Wikipedia: In molecular biology, translation initiation factor IF-3 is one of the three factors required for the initiation of protein biosynthesis in bacteria. IF-3 is thought to function as a fidelity factor during the assembly of the ternary initiation complex which consists of the 30S ribosomal subunit, the initiator tRNA and the messenger RNA. IF-3 is a basic protein that binds to the 30S ribosomal subunit. The chloroplast homolog enhances the poly(A,U,G)-dependent binding of the initiator tRNA to its ribosomal 30s subunits. IF1–IF3 may also perform ribosome recycling.
Pfam PF15763: Regulator of human erythroid cell expansion (RHEX) (family)
This family of proteins is found in eukaryotes. Family members include human RHEX proteins which regulates erythroid progenitor cell expansion and erythroblast development.
Pfam PF24814: Prp19 WD40 domain (repeat)
This entry represents the WD40 domain of Prp19 from animals, which consists of a regular beta-propeller architecture. Prp19 is essential for spliceosome assembly and stability, a core component of the NCT complex, part of the spliceosome. Prp19 self-associates through this domain and a central coiled-coil which is key for the foundation of NTC complex assembly.
Pfam PF14406: Ribosomally synthesized peptide in Bacteroidetes (family)
Ribosomally synthesized peptide that is usually in the gene neighborhood of a RimK-like ATP-grasp, and an ABC ATPase fused to  a papain-like domain. It is often present in multiple tandem gene copies. The gene contexts suggest that it is modified by the  ATP-grasp as in the biosynthesis of microviridin and marinostatin.  They might function in defense or development or as peptide antibiotics.
Pfam PF25072: Domain of unknown function (DUF7796) (domain)
This domain is found in uncharacterised proteins mainly from plants. It is predicted to adopt a globular alpha/ beta structure containing several disulfide bonds made by highly conserved cysteine residues.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF25043: Domain of unknown function (DUF7788) (domain)
This is a vWA-like domain found at the C-terminal of uncharacterised proteins containing the [pfam:PF11443] domain at the N-terminal.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF15291: Dermcidin, antibiotic peptide (domain)
Dermcidin is a family of peptides produced in the sweat to protect against pathogenic Gram-positive bacteria.
Pfam PF04863: Alliinase EGF-like domain (domain)
Allicin is a thiosulphinate that gives rise to dithiines, allyl sulphides and ajoenes, the three groups of active compounds in Allium species. Allicin is synthesised from sulfoxide cysteine derivatives by alliinase ([ec:4.4.1.4]), whose C-S lyase activity cleaves C(beta)-S(gamma) bonds. It is thought that this enzyme forms part of a primitive plant defence system. This family represents the  N-terminal EGF-like domain.
Wikipedia: In enzymology, an alliin lyase is an enzyme that catalyzes the chemical reactionan S-alkyl-L-cysteine S-oxide  an alkyl sulfenate + 2-aminoacrylate
Pfam PF20692: Circularly permuted SF2 helicase found in GREB1 proteins (domain)
This entry represents a circularly-permuted Superfamily 2 helicase found N-terminal to the Glycosyltransferase domain in eukaryotic GREB1-like proteins. Some versions, such as the human GREB1 and GREB1L are predicted to be inactive.
Pfam PF24100: Domain of unknown function (DUF7381) (domain)
This domain is found N-terminal in uncharacterised nematode proteins. It is predicted to adopt a globular alpha/beta structure.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF15833: Domain of unknown function (DUF4714) (family)
This family of proteins is found in eukaryotes. Proteins in this family are typically between 143 and 164 amino acids in length.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF22469: RavJ, Peptidase domain (domain)
This entry represents the N-terminal cysteine proteinase domain of RavJ from Legionella pneumophila.
Pfam PF04973: Nicotinamide mononucleotide transporter (family)
Members of this family are integral membrane proteins that are involved in transport of nicotinamide mononucleotide.
Wikipedia: The Nicotinamide Ribonucleoside (NR) Uptake Permease (PnuC) Family is a family of transmembrane transporters that is part of the TOG superfamily. Close PnuC homologues are found in a wide range of Gram-negative and Gram-positive bacteria, archaea and eukaryotes.
Pfam PF23229: Alpha-glucan water dikinase, DUF7067 (domain)
This domain is found in two tandem copies in the Alpha-glucan water dikinase (GWD1 and GWD2) from Arabidopsis thaliana and related proteins. It is predicted to adopt a globular structure consisting of three helical bundle. GWD1 is involved in the incorporation of phosphate into starch-like alpha-glucan, mostly at the C-6 position of glucose units. This enzyme acts as regulator of starch mobilization by controlling the phosphate content of starch. The function of the domain represented in this entry is unknown.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF05004: Interferon-related developmental regulator (IFRD) (repeat)
Interferon-related developmental regulator (IFRD1) is the human homologue of the rat early response protein PC4 and its murine homologue TIS7.  The exact function of IFRD1 is unknown but it has been shown that PC4 is necessary to muscle differentiation and that it might have a role in signal transduction. This family also contains IFRD2 and its murine equivalent SKMc15 which are highly expressed soon after gastrulation and in the hepatic primordium, suggesting an involvement in early hematopoiesis.