SII-SWORD/CoKE huggingface dataset:
Pfam PF02718: Herpesvirus UL31-like protein (family)
This is a family of Herpesvirus proteins including UL31 ([swissprot:P10215]), UL53 ([swissprot:P16794]), and the  product of ORF 69 in some strains (e.g. [swissprot:O36420]). The proteins in this family have no known function.
Pfam PF10716: NADH dehydrogenase transmembrane subunit (family)
The NdhL family is a component of the NDH-1L complex that is one of the proton-pumping NADH:ubiquinone oxidoreductases that catalyse the electron transfer from NADH to ubiquinone linked with proton translocation across the membrane. NDH-1L is essential for photoheterotrophic cell growth. NdhL appears to contain two transmembrane helices and it is necessary for the functioning of though not the correct assembly of the NDH-1 complex in Synechocystis 6803. The conservation between cyanobacteria and green plants suggests that chloroplast NDH-1 complexes contain related subunits.
Pfam PF18242: Legionella ubiquitin-specific protease A domain (domain)
This domain is found in Legionella ubiquitin-specific protease A (LupA). LupA removes a ubiquitin modification from LegC3 which inactivates the cognate effector. This domain is typical of eukaryotic ubiquitin proteases involved in deconjugation of ubiquitin or ubiquitin-like proteins from their targets.
Pfam PF00985: Merozoite Surface Antigen 2 (MSA-2) family (family)
This entry represents a protein family specific to the genus Plasmodium. The merozoite surface antigen 2 (MSA-2) may play a role in the merozoite attachment to the erythrocyte. This protein was proposed to be a candidate for a protective vaccine against malaria .
Pfam PF10934: Protein of unknown function (DUF2634) (family)
Some members in this family of proteins are annotated as phage related, xkdS however currently there is no known function.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF03563: Bunyavirus glycoprotein G2 (family)
Bunyavirus has three genomic segments: small (S), middle-sized (M), and large (L). The S segment encodes the nucleocapsid and a non-structural protein. The M segment codes for two glycoproteins, G1 and G2, and another non-structural protein (NSm). The L segment codes for an RNA polymerase.  This family contains the G2 glycoprotein which interacts with the [pfam:PF03557] G1 glycoprotein.
Pfam PF24046: At4g08330 beta-tent (domain)
This domain is found in uncharacterised protein At4g08330 from Arabidopsis thaliana and related plant proteins. It is closely related to SelR domain [[pfam:PF01641]]. It is predicted to adopt a typical beta-tent fold with zinc coordinating residues conserved.
Pfam PF23610: VWA7 beta-sandwich domain (domain)
This domain is found in the human von Willebrand factor A domain-containing protein 7 and related proteins. This protein is found in the major histocompatibility complex class III region and it is likely implicated in lung cancers. The domain represents in this entry is predicted to fold into a beta-sandwich.
Pfam PF08998: Bacterial epsilon antitoxin (domain)
The epsilon antitoxin, produced by various prokaryotes, forms part of a postsegregational killing system which is involved in the initiation of programmed cell death of plasmid-free cells. The protein is folded into a three-helix bundle that directly interacts with the zeta toxin, inactivating it.
Wikipedia: In molecular biology, the epsilon antitoxin, produced by various prokaryotes, forms part of a post-segregational killing system, which is involved in the initiation of programmed cell death of plasmid-free cells. The protein is folded into a three-helix bundle that directly interacts with the zeta toxin, inactivating it.
Pfam PF07688: KaiA C-terminal domain (domain)
The cyanobacterial clock proteins KaiA and KaiB are proposed as regulators of the circadian rhythm in cyanobacteria. The overall fold of the KaiA C-terminal domain is that of a four-helix bundle, which forms a dimer in the known structure.
Wikipedia: In molecular biology, the cyanobacterial clock proteins are the main circadian regulator in cyanobacteria. The cyanobacterial clock proteins comprise three proteins: KaiA, KaiB and KaiC. The kaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction. This complex is expressed from a KaiABC operon.
Pfam PF20351: Family of unknown function (DUF6646) (family)
This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 170 amino acids in length.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF13370: 4Fe-4S single cluster domain of Ferredoxin I (domain)
Fer4_13 is a ferredoxin I from sulfate-reducing bacteria. Chemical sequence analysis suggests that this characteristic [4Fe-4S] cluster sulfur environment is widely distributed among ferredoxins.
Pfam PF10871: Protein of unknown function (DUF2748) (family)
This is a bacterial family of proteins with unknown function.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF04357: TamB, inner membrane protein subunit of TAM complex (repeat)
TamB is an integral inner membrane protein that forms a complex - the translocation and assembly module or TAM - with the outer membrane protein, TamA. TAM is responsible for the efficient secretion of the adhesin protein Ag43 in E.coli K-12.
Pfam PF11111: Centromere protein M (CENP-M) (family)
The prime candidate for specifying centromere identity is the array of nucleosomes assembles with CENP-A. CENP-A recruits a nucleosome associated complex (NAC) comprised of CENP-M along with two other proteins. Assembly of the CENP-A NAC at centromeres is partly dependant on CENP-M. The CENP-A NAC is essential, as disruption of the complex causes errors of chromosome alignment and segregation that preclude cell survival.
Pfam PF15678: Centriole duplication and mitotic chromosome congression (family)
SPICE is a family of proteins found in chordates. It localises to spindle microtubules in mitosis and to centrioles throughout the cell cycle. Deletion of SPICE compromises the architecture of spindles, the integrity of the spindle pole and the process of aligning chromosomes on the spindle (chromosome congression).
Pfam PF06193: Orthopoxvirus A5L protein-like (family)
This family includes several Orthopoxvirus A5L proteins. The vaccinia virus WR A5L open reading frame (corresponding to open reading frame A4L in vaccinia virus Copenhagen) encodes an immunodominant late protein found in the core of the vaccinia virion. The A5 protein appears to be required for the immature virion to form the brick-shaped intracellular mature virion.
Pfam PF24757: ASCIZ fist and second C2H2 zinc finger domains (domain)
This domains are found in the human ATM interactor (also known as ATM/ATR-substrate CHK2-interacting zinc finger protein (ASCIZ)) and related proteins from animals.  These proteins are transcription factors that are essential for cell survival and the formation of RAD51 foci, a response to methylating DNA damage. They are also involved in the regulation of ATM (ataxia telangiectasia mutated) kinase activity, particularly in the absence of DNA damage, potentially by stabilising ATM. ASCIZ is predicted to contain four zinc finger domains. This entry represents the first two of them.
Pfam PF15311: Hydrolethalus syndrome protein 1 C-terminus (family)
This entry represents the C-terminal domain of Centriolar and ciliogenesis-associated protein HYLS1. The HYLS1 gene shows alternative splicing and the transcript is found in multiple tissues during foetal development .
Wikipedia: Hydrolethalus syndrome protein 1 is a protein that in humans is encoded by the HYLS1 gene.
Pfam PF17162: Domain of unknown function (DUF5118) (family)
This domain falls upstream of a met-zincin domain.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF09766: Fms-interacting protein/Thoc5 (family)
This entry carries part of the crucial 144 N-terminal residues of the FmiP (Fms interacting protein). A member of the THO (suppressors of the transcriptional defects of hpr1delta by overexpression) complex which is a subcomplex of the transcription/export (TREX) complex. It is essential for the binding of the protein to the cytoplasmic domain of activated Fms-molecules in M-CSF induced haematopoietic differentiation of macrophages. Fmip is also known as THOC5 (THO complex subunit 5) a 683 amino acids long protein which contains a nuclear localisation sequence (NLS), a leucine zipper and a PEST like sequence (aa. 303-319) that carries three ataxia-telangiectasia mutated (ATM) kinase specific phosphorylation sites. The C-terminus contains a THOC1 binding site. The level of FMIP/Thoc5 expression might form a threshold that determines whether cells differentiate into macrophages or into granulocytes.
Pfam PF04229: GrpB protein (domain)
This family has been suggested to belong to the nucleotidyltransferase superfamily.  It occurs at the C-terminus of dephospho-CoA kinase (CoaE) in a number of cases, where it plays a role in the proper folding of the enzyme.
Pfam PF16310: Domian of unknown function (DUF4952) (family)
This family consists of several uncharacterized proteins around 150 residues in length and is mainly found in various Leptospira, Pseudomonas, Stenotrophomonas and Desulfovibrio species. The function of this family is unknown.
Pfam PF20368: Family of unknown function (DUF6663) (family)
This family of proteins is functionally uncharacterised. This family of proteins is found in archaea. Proteins in this family are typically between 194 and 253 amino acids in length.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF02185: Hr1 repeat (family)
The HR1 repeat was first described as a three times repeated homology region of the N-terminal non-catalytic part of protein kinase PRK1(PKN). The first two of these repeats were later shown to bind the small G protein rho known to activate PKN in its GTP-bound form. Similar rho-binding domains also occur in a number of other protein kinases and in the rho-binding proteins rhophilin and rhotekin. Recently, the structure  of the N-terminal HR1 repeat complexed with RhoA has been determined by X-ray crystallography. It forms  an antiparallel coiled-coil fold termed an ACC finger.
Pfam PF08882: Acetone carboxylase gamma subunit (domain)
Acetone carboxylase is the key enzyme of bacterial acetone metabolism, catalysing the condensation of acetone and CO(2) to form acetoacetate.
Pfam PF09084: NMT1/THI5 like (family)
This family contains the NMT1 and THI5 proteins.  These proteins are proposed to be required for the biosynthesis of the pyrimidine moiety of thiamine.  They are regulated by thiamine. The protein adopts a fold related to the periplasmic binding protein (PBP) family. Both pyridoxal-5'-phosphate (PLP) and an iron atom are bound to the protein suggesting numerous residues of the active site necessary for HMP-P biosynthesis. The yeast protein is a dimer and, although exceptionally using PLP as a substrate, has notable similarities with enzymes dependent on this molecule as a cofactor.
Pfam PF18986: Family of unknown function (DUF5719) (repeat)
This is a family of unknown function, mostly found in bacteria. According to structure predictions, members of this entry may consist of a novel repeat fold containing four repeat units, each of them containing eight antiparallel beta-strands.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF14707: C-terminal region of aryl-sulfatase (domain)
Wikipedia: In biochemistry, sulfatases EC 3.1.6.- are a class of enzymes of the esterase class that catalyze the hydrolysis of sulfate esters into an alcohol and a bisulfate:
Pfam PF20712: Cyanobacterial TRADD-N associated 2-Transmembrane domain (domain)
This is a domain with two transmembrane helices predicted to function as a pore-forming effector and found mainly in bacterial conflict systems.
Pfam PF05753: Translocon-associated protein beta (TRAPB) (family)
This family consists of several eukaryotic translocon-associated protein beta (TRAPB) or signal sequence receptor beta subunit (SSR-beta) proteins. The normal translocation of nascent polypeptides into the lumen of the endoplasmic reticulum (ER) is thought to be aided in part by a translocon-associated protein (TRAP) complex consisting of 4 protein subunits. The association of mature proteins with the ER and Golgi, or other intracellular locales, such as lysosomes, depends on the initial targeting of the nascent polypeptide to the ER membrane. A similar scenario must also exist for proteins destined for secretion.
Pfam PF09752: Alpha/beta hydrolase domain containing 18 (family)
This entry represents alpha/beta hydrolase domain-containing protein 18 (ABHD18). Its function is not clear.
Pfam PF06009: Laminin Domain II (coiled_coil)
It has been suggested that the domains I and II from laminin A, B1 and B2 may come together to form a triple helical coiled-coil structure.
Wikipedia: Laminins are a family of glycoproteins of the extracellular matrix of all animals. They are major constituents of the basement membrane, namely the basal lamina. Laminins are vital to biological activity, influencing cell differentiation, migration, and adhesion.
Pfam PF07317: Flagellar regulator YcgR, PilZN domain (domain)
This domain is found N terminal to [pfam:PF07238], therefore named PilZN. Proteins which contain PilZN (also known as YcgR) are know to interact with the flagellar switch-complex proteins FliG and FliM. This interaction results in a reduction of torque generation and induces CCW motor bias. This domain exhibits a similar structur as PilZ domains comprising a beta-barrel fold but lack the C-terminal alpha-helix.
Pfam PF18443: Tle cognate immunity protein 4 N-terminal domain (domain)
T6SS bacteria employ toxic effectors to inhibit rival cells and concurrently use effector cognate immunity proteins to protect their sibling cells. The effector and immunity pairs (E-I pairs) endow the bacteria with a great advantage in niche competition. This is the C-terminal domain of Tli4. The Tle cognate immunity proteins (Tlis) can directly disable the transported Tle protein and thereby mediate the self-protection process. The Tle-Tli effector-immunity (E-I) pairs confer substantial advantage to the donor cell during interbacterial competition. Tli4 displays a two-domain conformation (domains I and II) and contains 17 beta-strands and four helices . These two domains pack into a crab claw-like conformation functioning as an inhibitor of Tle4. Both domains adopt an alpha+beta architecture. Domain I features a central antiparallel beta-sheet sandwiched by two helices and a short antiparallel beta-sheet. This entry comprises the N-terminal domain I found in Tli4 proteins.
Pfam PF19451: Family of unknown function (DUF5989) (family)
This family of proteins is primarily found in bacteria. Proteins in this family are integral membrane proteins that are approximately 50 amino acids in length. There is a C-terminal conserved APFIY sequence motif. This family may have distant partial similarity to [pfam:PF02694] suggesting this may be a transporter protein.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF00705: Proliferating cell nuclear antigen, N-terminal domain (domain)
N-terminal and C-terminal domains of PCNA are topologically identical.  Three PCNA molecules are tightly associated to form a closed ring encircling duplex DNA.
Wikipedia: A DNA clamp, also known as a sliding clamp, is a protein complex that serves as a processivity-promoting factor in DNA replication. As a critical component of the DNA polymerase III holoenzyme, the clamp protein binds DNA polymerase and prevents this enzyme from dissociating from the template DNA strand. The clamp-polymerase protein–protein interactions are stronger and more specific than the direct interactions between the polymerase and the template DNA strand; because one of the rate-limiting steps in the DNA synthesis reaction is the association of the polymerase with the DNA template, the presence of the sliding clamp dramatically increases the number of nucleotides that the polymerase can add to the growing strand per association event. The presence of the DNA clamp can increase the rate of DNA synthesis up to 1,000-fold compared with a nonprocessive polymerase.
Pfam PF14154: Domain of unknown function (DUF4306) (family)
This family includes the B. subtilis YjdJ protein [swissprot:O05524], which is functionally uncharacterised.  This is not a homologue of E. coli YjdJ, which belongs to [pfam:PF00583].  This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 95 and 152 amino acids in length.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF05024: N-acetylglucosaminyl transferase component (Gpi1) (family)
Glycosylphosphatidylinositol (GPI) represents an important anchoring  molecule for cell surface proteins.The first step in its synthesis is the transfer of N-acetylglucosamine (GlcNAc) from UDP-N-acetylglucosamine to  phosphatidylinositol (PI). This chemically simple step is genetically  complex because three or four genes are required in both yeast  (GPI1, GPI2 and GPI3) and mammals (GPI1, PIG A, PIG H and PIG C), respectively.
Pfam PF17354: Family of unknown function (DUF5382) central domain (domain)
This is a domain of unknown function found in Caenorhabditis. It has an NTF2-like fold.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF16737: PHD finger protein 12 MRG binding domain (domain)
This domain found in PHD finger protein 12 binds to the MRG domain of Mortality factor 4-like protein 1.
Pfam PF10009: Uncharacterized protein conserved in bacteria (DUF2252) (family)
This domain, found in various hypothetical bacterial proteins, has no known function.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF03820: Sideroflexins (family)
This family contains sideroflexin 1, 2 and 3 (SFXN1/2/3). SFXN1 is a multipass mitochondrial membrane protein and is part of the sideroflexin family of proteins conserved throughout eukaryotes. In humans, SFXN1 is highly expressed in the blood, liver, and kidney, which are tissues with high one-carbon metabolism activity. SFXN1 functions as a mitochondrial serine transporter in one-carbon metabolism. SFXN1 and SFXN3 (and perhaps SFXN2) are the main mitochondrial serine transporters in human cells and Sfxn1-3 also have this function in D. melanogaster. SFXN1 and SFXN3 likely have other physiologically relevant substrates besides serine, such as alanine or cysteine. Because SFXN1 is expressed in many cancers most highly in leukemias and lymphomas and its expression is likely regulated by the Myc transcription factor, it is suggested that it may have roles in cancer cell growth. Furthermore, Myc-binding sites were found in the promoters of SFXN1, SFXN2, and SFXN3.
Pfam PF12373: Major surface glycoprotein 2 C terminal (family)
This domain family is found in eukaryotes, and is approximately 30 amino acids in length. The family is found in association with [pfam:PF02349]. This family is the C terminal of major surface glycoprotein 2 of virulent bacteria. It is a virulence factor antigen.
Pfam PF01954: AF2212-like (family)
This family includes short bacterial and archaebacterial proteins thought to be antitoxin components of the a type II toxin-antitoxin (TA) system. This entry includes AF2212 from Archaeoglobus fulgidus which has sequence similarity with the AbrB superfamily of DNA-binding proteins, identified as antitoxins. The secondary structure of AF2212 revealed at least three beta-strands that are most conserved in other AbrB superfamily members.
Pfam PF08437: Glycosyl transferase family 8 C-terminal (family)
This domain is found at the C-terminus of the Pfam: PF01501 domain in bacterial glucosyltransferase and galactosyltransferase proteins.
Pfam PF13453: Transcription factor zinc-finger (domain)
This entry represents a zinc-finger domain.