SII-SWORD/CoKE huggingface dataset:
Pfam PF06656: Tenuivirus PVC2 protein (family)
This family consists of several Tenuivirus PVC2 proteins from Rice grassy stunt virus, Maize stripe virus and Rice hoja blanca virus. The function of this family is unknown.
Pfam PF20530: Domain of unknown function (DUF6745) (domain)
This presumed domain is functionally uncharacterised. This domain family is found in bacteria, and is typically 200 amino acids in length.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF06116: Transcriptional activator RinB (family)
This family consists of several Staphylococcus aureus bacteriophage RinB proteins and related sequences from their host. The int gene of staphylococcal bacteriophage phi 11 is the only viral gene responsible for the integrative recombination of phi 11. rinA and rinB, are both required to activate expression of the int gene.
Pfam PF03030: Inorganic H+ pyrophosphatase (family)
The H+ pyrophosphatase is an transmembrane proton pump involved in establishing the H+ electrochemical potential difference between the vacuole lumen and the cell cytosol. Vacuolar-type H(+)-translocating inorganic pyrophosphatases have long been considered to be restricted to plants and to a few species of photo-trophic bacteria. However, in recent investigations, these pyrophosphatases have been found in organisms as disparate as thermophilic Archaea and parasitic protists.
Wikipedia: Members of the H+, Na+-translocating Pyrophosphatase (M+-PPase) Family (TC# 3.A.10) are found in the vacuolar (tonoplast) membranes of higher plants, algae, and protozoa, and in both bacteria and archaea. They are therefore ancient enzymes.
Pfam PF12519: Mitochondrial distribution and morphology protein 10 (family)
MDM10 is a family of eukaryotic proteins that forms a subunit of the SAM complex for biogenesis of beta-barrel proteins, though not porins, into the outer mitochondrial membrane.
Pfam PF15470: C17orf50 C-terminal zinc-binding domain (domain)
This entry represents a likely zinc-binding domain found at the C-terminus of the C17orf50 protein found in eukaryotes. Proteins in this family are typically between 142 and 178 amino acids in length.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF06423: GWT1 (family)
Glycosylphosphatidylinositol (GPI) is a conserved post-translational modification to anchor cell surface proteins to plasma membrane in eukaryotes. PIGW and the yeast homologue GWT1 are involved in the  addition of the acyl-chain to inositol in an early step of GPI  biosynthesis. Mutations in PIGW are associated with West  syndrome and hyperphosphatasia with mental retardation syndrome.
Pfam PF01670: Glycosyl hydrolase family 12 (domain)
Glycoside hydrolase family 12 GH12 comprises enzymes with two known activities: Endo-Î²-1,4-glucanase (3.2.1.4) and Xyloglucan-specific endo-Î²-1,4-glucanase / endo-xyloglucanase (3.2.1.151). These enzymes were formerly known as cellulase family H.
O-Glycosyl hydrolases (3.2.1.) are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycosyl hydrolases, based on sequence similarity, has led to the definition of 85 different families . This classification is available on the CAZy (CArbohydrate-Active EnZymes) website.
Wikipedia: In molecular biology, Glycoside hydrolase family 12 is a family of glycoside hydrolases.
Pfam PF04781: Protein of unknown function (DUF627) (family)
This family represents the N-terminal region of several plant proteins of unknown function.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF14490: ATP-dependent RecD2 DNA helicase HHH domain (domain)
This presumed domain contains at least one helix-hairpin-helix motif. This domain is often found in ATP-dependent RecD2 DNA helicase from Bacillus subtilis and similar bacterial sequences. RecD2 may favour replication restart by preventing RecA from binding to blocked replication forks, avoiding unnecessary recombination during replication restart. It acts as a negative modulator of the RecA-ssDNA filament, and it may disassemble RecA threads. It can act as both a positive and negative regulator of strand exchange.
Pfam PF15573: Immunity protein 47 (family)
A predicted immunity protein with an alpha+beta fold and a conserved KxGDxxK motif. Proteins containing this domain are present in heterogeneous poly-immunity loci in polymorphic toxin systems.
Pfam PF03721: UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain (domain)
The UDP-glucose/GDP-mannose dehydrogenaseses are a small group of enzymes which possesses the ability to catalyse the NAD-dependent 2-fold oxidation of an alcohol to an acid without the release of an aldehyde  intermediate.
Pfam PF23121: AIPP2, SPOC-like domain (domain)
This entry represents the SPOC-like domain found in PHD-containing proteins present in plants, including Arabidopsis thaliana. This domain might be involved in protein interactions.
Pfam PF09241: Herpesviridae viral cyclin (domain)
Members of this family of viral cyclins adopt a helical structure consisting of five alpha-helices, with one helix surrounded by the others. They specifically activate CDK6 of host cells to a very high degree.
Pfam PF14084: Protein of unknown function (DUF4264) (family)
This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 60 amino acids in length.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF08062: NOP2 repeat (repeat)
This entry represents a characteristic repeat found in 28S rRNA (cytosine-C(5))-methyltransferase (NOP2, also known as proliferating cell nuclear antigen p120, which it is found in three copies. NOP2 is involved in ribosomal large subunit assembly. It is also a SAM-dependent methyltransferase that specifically methylates the C5 position of cytosine 4447 in 28S rRNA.
Pfam PF02045: CCAAT-binding transcription factor (CBF-B/NF-YA) subunit B (family)
Diverse DNA binding proteins are known to bind the CCAAT box, a common cis- acting element found in the promoter and enhancer regions of a large number of genes in eukaryotes. Amongst these proteins is one known as the CCAAT-binding factor (CBF) or nuclear transcription factor Y (NF-Y) . CBF is a heteromeric transcription factor that consists of two different components both needed for DNA-binding.

The HAP protein complex of yeast binds to the upstream activation site of cytochrome C iso-1 gene (CYC1) as well as other genes involved in mitochondrial electron transport and activates their expression. It also recognises the sequence CCAAT and is structurally and evolutionary related to CBF.

The first subunit of CBF is known as CBF-A or NF-YB in vertebrates, and HAP3 in budding yeast. The second subunit is known as CBF-B or NF-YA in vertebrates and HAP2 in budding yeast. It is a protein of 265 to 350 amino-acid residues which contains a highly conserved region of about 60 residues. This region, called the 'essential core' , seems to consist of two subdomains: an N-terminal subunit-association domain and a C-terminal DNA recognition domain.

This entry represents the NF-YA subunit.
Pfam PF16780: AIMP2 lysyl-tRNA synthetase binding domain (domain)
This is the lysyl-tRNA synthetase binding domain of aminoacyl tRNA synthase complex-interacting multifunctional protein 2 (AIMP2).
Pfam PF06308: 23S rRNA methylastransferase leader peptide (ErmCL) (family)
This family consists of several very short bacterial 23S rRNA methylase leader peptide (ErmCL) sequences. ermC confers resistance to macrolide-lincosamide streptogramin B antibiotics by specifying a ribosomal RNA methylase, which results in decreased ribosomal affinity for these antibiotics. ermC expression is induced by exposure to erythromycin and is controlled by an uORF encoding the leader peptide ErmCL.  It has been shown that the four C-terminal ErmCL residues I6F7V8I9 are crucial for ribosome stalling and that translation is arrested likely due to the PTC adopting an inactive conformation that prevents peptide bond formation with the incoming Ser-tRNASer at the 10th ermCL codon position.
Pfam PF10614: Type VIII secretion system (T8SS), CsgF protein (family)
The extracellular nucleation-precipitation (ENP) pathway or Type VIII secretion system (T8SS) in Gram-negative (diderm) bacteria is responsible for the secretion and assembly of prepilins for fimbiae biogenesis, the prototypical curli. Besides the T2SS that can be involved in the assembly of prototypical Type 4 pilus, the T4SS that can be involved in the biogenesis of the prototypical pilus T, the T3SS involved in the assembly of the injectisome and the T7SS involved in the formation of the prototypical Type 1 pilus, the T8SS differs in that fibre-growth occurs extracellularly. The curli, also called thin aggregative fimbriae (Tafi), are the only fimbriae dependent on the T8SS. Tafi were first identified in Salmonella spp and the controlling operon termed agf; however subsequent isolation of the homologous operon in E coli led to its being called csg. In the absence of extracellular polysaccharides Tafi appear curled, although when expressed with such polysaccharides their morphology appears as a tangled amorphous matrix. CsgF is one of three putative curli assembly factors appearing to act as a nucleator protein. Unlike eukaryotic amyloid formation, curli biogenesis is a productive pathway requiring a specific assembly machinery.
Pfam PF18574: C2HC Zing finger domain (domain)
This is a zinc finger domain together with a linker region found in RNF125, a small protein (25kD) that contains a RING domain, three zinc fingers (ZnFs) and a ubiquitin interacting motif (UIM). The C2HC ZnF plays an essential role in the interaction of RNF125 with the E2 UbcH5a, which originates from the requirement of the C2HC-ZnF for the structural stability of the RING domain. A mutation at one of the contact residues in the C2HC-ZnF, a highly conserved M112, resulted in the loss of ubiquitin ligase activity. Furthermore, mutations at the Zn2+ chelating cysteine residues, C100 and C103 of this domain resulted in a loss of activity.
Pfam PF21794: RAD51D, N-terminal domain (domain)
RAD51D plays an important role in DNA repair by homologous recombination (HR) and together with other RAD51 paralogues, RAD51B, RAD51C, XRCC3 and XRCC2, helps recruiting RAD51 to the break site. This entry represents the N-terminal domain which is essential for protein-protein interaction with XRCC2 and consists of four short helices flanked by long N- and C-terminal tails. This domain can bind DNA, preferentially ssDNA.
Pfam PF02701: Dof domain, zinc finger (family)
The Dof domain is a zinc finger DNA-binding domain, that shows resemblance to the zinc beta-ribbon domains.
Pfam PF24509: TXNDC16 second thioredoxin-like domain (domain)
This entry represents the second thioredoxin-like domain of TXNDC16. The function of these proteins is unknown.
Pfam PF11915: Protein of unknown function (DUF3433) (family)
This is a family of functionally uncharacterised proteins. The family is found in eukaryotes, and represents the conserved central region of the member proteins.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF17948: DnaT DNA-binding domain (domain)
This domain is found in E.coli primosomal protein 1 (Pp1). PP1 domain (residues 84-153) in [swissprot:P0A8J2] can bind to different types of ssDNA, which is fundamental for its physiological substrate bindings. Functional analysis indicate that both N- and C- terminals are essential to having the cooperative effect in binding ssDNA. The ssDNA bound complex displays a spiral filament assembly that is adopted by many proteins that are involved in DNA replication, such as DnaA, RecA and PriB. This domain is similar to [pfam:PF08585] except that it contains an extra loop at the N-terminus (84-99). Structural analysis indicate that this extra loop might be essential for the stabilisation of the three-helix bundle.
Pfam PF02422: Keratin (family)
This family represents avian keratin proteins, found in feathers, scale and claw.
Wikipedia: Beta-keratin (β-keratin) is a member of a structural protein family found in the epidermis of reptiles and birds. Beta-keratins were named so because they are components of epidermal stratum corneum rich in stacked beta sheets, in contrast to alpha-keratins, intermediate-filament proteins also found in stratum corneum and rich in alpha helices. Because the accurate use of the term keratin is limited to the alpha-keratins, the term "beta-keratins" in recent works is replaced by "corneous beta-proteins" or "keratin-associated beta-proteins."
Pfam PF15868: Transcription activator MBF2 (family)
MBF2 activates transcription via its interaction with TFIIA. In Bombyx mori, it has been found to form a complex with MBF1 and the DNA-binding regulator FTZ-F1.
Pfam PF02876: Staphylococcal/Streptococcal toxin, beta-grasp domain (domain)
Staphylococcal enterotoxins and streptococcal pyrogenic exotoxins constitute a family of biologically and structurally related toxins produced by Staphylococcus aureus and Streptococcus pyogenes . These toxins share the ability to bind to the major histocompatibility complex proteins of their hosts. A more distant relative of the family is the S. aureus toxic shock syndrome toxin, which shares only a low level of sequence similarity with this group.

All of these toxins share a similar two-domain fold (N and C-terminal domains) with a long Î±-helix in the middle of the molecule, a characteristic Î²-barrel known as the "oligosaccharide/oligonucleotide fold" at the N-terminal domain and a Î²-grasp motif at the C-terminal domain. Each superantigen possesses slightly different binding mode(s) when it interacts with MHC class II molecules or the T-cell receptor .

The Î²-grasp domain has some structural similarities to the Î²-grasp motif present in immunoglobulin-binding domains, ubiquitin, 2Fe-2 S ferredoxin and translation initiation factor 3 as identified by the SCOP database.
Wikipedia: An enterotoxin is a protein exotoxin released by a microorganism that targets the intestines. They can be chromosomally or plasmid encoded. They are heat labile, of low molecular weight and water-soluble. Enterotoxins are frequently cytotoxic and kill cells by altering the apical membrane permeability of the mucosal (epithelial) cells of the intestinal wall. They are mostly pore-forming toxins, secreted by bacteria, that assemble to form pores in cell membranes. This causes the cells to die.
Pfam PF06719: AraC-type transcriptional regulator N-terminus (family)
This family represents the N-terminus of bacterial ARAC-type transcriptional regulators. In E. coli, these regulate the L-arabinose operon through sensing the presence of arabinose, and when the sugar is present, transmitting this information from the arabinose-binding domains to the protein's DNA-binding domains. This family might represent the N-terminal arm of the protein, which binds to the C-terminal DNA binding domains to hold them in a state where the protein prefers to loop and remain non-activating. All family members contain the [pfam:PF00165] domain.
Pfam PF09575: Small spore protein J (Spore_SspJ) (family)
Spore_SspJ represents a group of small acid-soluble proteins (SASP) from Bacillus sp., which are present in spores but not in growing cells. The sspJ gene is transcribed in the forespore compartment by RNA polymerase with the forespore-specific sigmaG. Loss of SspJ causes a slight decrease in the rate of spore outgrowth in an otherwise wild-type background.
Pfam PF06587: Protein of unknown function (DUF1137) (family)
This family consists of several hypothetical proteins specific to Chlamydia species. The function of this family is unknown.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF21197: PgaA membrane beta barrel domain (domain)
The partially de-N-acetylated poly-beta-1,6-N-acetyl-d-glucosamine (dPNAG) polymer serves as an intercellular biofilm adhesin that plays an essential role for the development and maintenance of integrity of biofilms of diverse bacterial species. Translocation of dPNAG across the bacterial outer membrane is mediated by a tetratricopeptide repeat-containing outer membrane protein, PgaA. This entry represents the PgaA membrane beta barrel domain.
Pfam PF15836: SSTK-interacting protein, TSSK6-activating co-chaperone protein (family)
SSTK-IP, SSTK-interacting protein or TSSK6-activating co-chaperone, is a family of proteins found in eukaryotes. SSTK-IP directly binds to HSP70, is found associated with HSP70 and HSP90 in cells, and facilitates HSP90-dependent enzymatic activation of SSTK. SSTK is a small serine/threonine kinase expressed post-meiotically and essential for male fertility along with two other serine threonine kinases. SSTK is one of the smallest protein kinases, consisting only of N- and C-lobes of a kinase catalytic domain, and forms stable associations with heat shock protein (HSP) 70 and 90. SSTK-IP, its interacting protein, thus represents the first germ cell-specific co-chaperone and protein kinase that requires the HSP90 machinery for catalytic activation.
Pfam PF16992: DNA-directed RNA polymerase, subunit G (family)
RNA_pol_RpbG is a family of archaeal and fungal subunit G of DNA-directed RNA polymerase.
Pfam PF03753: Human herpesvirus 6 immediate early protein (family)
The proteins in this family are poorly characterised, but an investigationhas indicated that the immediate early protein is required the down-regulation of MHC class I expression in dendritic cells. Human herpesvirus 6 immediate early protein is also referred to as U90.
Pfam PF18817: Repeat of uncharacterized protein PH0542 (repeat)
Repeat found in PH0542 showing some sequence similarity to HEAT repeat.
Pfam PF22323: Uncharacterised protein aq_1974-like (family)
This protein family includes the uncharacterised protein aq_1974 from Aquifex aeolicus and similar sequences from thermophilic bacteria. This protein has a tryptophan content five times the average. Its structure is mainly alpha-helical with a small two-stranded beta-sheet forming a fold named 'Aromatic Claw'.
Pfam PF12201: Bcl2-interacting killer, BH3-domain containing (domain)
This is a family of pro-apoptotic Bcl-x proteins, B cell leukaemia/lymphoma 2, or BIKs.  BIK proteins rely for their activity upon an intact BH3 domain lying between residues 48 and 80, as in UniProt:Q13323.
Pfam PF10183: ESSS subunit of NADH:ubiquinone oxidoreductase (complex I) (family)
This subunit is part of the mitochondrial NADH:ubiquinone oxidoreductase (complex I). It carries mitochondrial import sequences.
Wikipedia: Respiratory complex I, EC 7.1.1.2 is the first large protein complex of the respiratory chains of many organisms from bacteria to humans. It catalyzes the transfer of electrons from NADH to coenzyme Q10 (CoQ10) and translocates protons across the inner mitochondrial membrane in eukaryotes or the plasma membrane of bacteria.
Pfam PF09991: Predicted membrane protein (DUF2232) (family)
This family of bacterial proteins are multi-pass membrane proteins with up to 10 (2 x 4/5) transmembrane regions. The exact function of this potential pore molecule is not known, but in many instances it is associated with ABC-transporter-like domains, implying that it is part of a secretion system that uses energy.
Pfam PF03180: NlpA lipoprotein (family)
This entry represents bacterial lipoproteins that belong to the NlpA family. It contains several antigenic members, that may be  involved in bacterial virulence. This entry includes the D-methionine binding lipoprotein MetQ, which is the substrate-binding component of a D-methionine permease, a binding protein-dependent,  ATP-driven transport system. Other members of this family, such as NlpA, have been identified as putative substrate-binding  components of ABC transporters. NlpA, is an inner-membrane-anchored  lipoprotein that has been shown to have a minor role in methionine  import.
Pfam PF16357: Putative PepSY_TM-like (family)
This is a family of bacterial proteins with three PepSY-like TM regions.
Pfam PF00133: tRNA synthetases class I (I, L, M and V) (domain)
Other tRNA synthetase sub-families are too dissimilar to be included.
Pfam PF01358: Poly A polymerase regulatory subunit (domain)
This family contains viral proteins that are bifunctional, acting as both an mRNA (nucleoside-2'-O-)-methyltransferase and a poly(A) polymerase processivity factor . The family also includes a number of uncharacterised eukaryotic sequences.
Pfam PF21892: TMEM145, N-terminal domain (domain)
This entry represents the N-terminal domain of TMEM145, which is a Golgi-dynamics (GOLD) domain. The function of TMEM145 is currently unknown. It is homologous to GPR180, TMEM181 and WLS, which together with TMEM87A/B, GPR107 and GPR108, are grouped as GOLD domain seven-transmembrane helix (GOST) proteins, regarding they share the same domain architecture.
Pfam PF03457: Helicase associated domain (domain)
This short domain is found in multiple copies in bacterial helicase proteins. The domain is predicted to contain 3 alpha helices.  The function of this domain may be to bind nucleic acid.
Pfam PF19006: Family of unknown function (DUF5735) (family)
A highly conserved domain of unknown function found in different Platyhelminthes.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.