SII-SWORD/CoKE huggingface dataset:
Pfam PF24564: Domain of unknown function (DUF7605) (domain)
This is an helical domain found at the C-terminal of fungal sequences, whose function is unknown.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF12574: 120 KDa Rickettsia surface antigen (family)
This domain family is found in bacteria, and is approximately 40 amino acids in length. This family is a Rickettsia surface antigen of 120 KDa which may be used as an antigen for immune response against the bacterial species.
Pfam PF21051: ARMC9, LIS1 homology motif (domain)
This is the Lis1H domain of ARMC9, a protein involved in ciliogenesis required for appropriate acetylation and polyglutamylation  of ciliary microtubules, and regulation of cilium length.
Pfam PF20357: Family of unknown function (DUF6652) (family)
This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 189 and 210 amino acids in length.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF21449: RIF2, ASCE domain (domain)
RIF2 is involved in transcriptional silencing and telomere length regulation. It belongs to the ATPase family associated with diverse cellular activities. This domain represents the ASCE (NTPase) domain described in.
Pfam PF09211: Domain of unknown function (DUF1958) (domain)
Members of this functionally uncharacterised family are found in prokaryotic penicillin-binding protein 4.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF20419: Family of unknown function (DUF6701) (family)
This entry represents an uncharacterised region found in a wide range of bacterial cell surface proteins.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF15437: Plasminogen-binding protein pgbA C-terminal (disordered)
PGBA_C is an C-terminal family of bacterial proteins that bind plasminogen. This activity was identified in Helicobacter pylori where it is thought to contribute to the virulence of this bacterium.  Both PgbA and PgbB are surface-exposed proteins that mediate binding to plasminogen such that it can be converted into plasmin in the presence of a plasminogen activator.
Pfam PF06196: Protein of unknown function (DUF997) (family)
Family of predicted bacterial membrane protein with unknown function.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF12961: Domain of unknown function (DUF3850) (domain)
The search results from NCBI sequence alignment indicates a conserved domain belonging to ASCH superfamily. Dali searching results show that the protein is a structurally similar to the PUA domain, suggesting it may be involved in RNA recognition. It has been reported that the deletion of PUA genes results in impaired growth (RluD) and competitive disadvantage (TruB) in Escherichia coli.  Suggestions have been put forward that, apart from their usual catalytic role, certain PUS enzymes (e.g. TruB) may also act as chaperones for RNA folding. The interface interaction indicates that the biomolecule of protein NP_809782.1 should be a dimer.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF22709: Mu Gam/Sipho_Gp157-like domain of the TOTE conflict systems (domain)
This entry represents a DNA/RNA hybrid duplex binding domain found in the TOTE (TPR, OB, TBP, Effector) conflict systems. This domain occasionally displaces the more widely observed TOTE-TPR domain.
Pfam PF08529: NusA N-terminal domain (domain)
This domain represents the RNA polymerase binding domain of NusA.
Pfam PF22972: EVH1-like domain in PP4R3 protein (domain)
The PPP4R3 regulatory subunits contain a conserved N-terminal Enabled/VASP Homology 1 (EVH1) domain. EVH1 domains are found in numerous proteins and bind to proline-rich sequences that adopt a left-handed PPII polyproline helix. Common to all EVH1 domains is a conserved tryptophan residue interacting with a proline residue in the ligand. This domain has been shown to bind an FXXP motif.
Pfam PF16040: E3 ubiquitin-protein ligase APD1-4, N-terminal (domain)
This entry includes E3 ubiquitin-protein ligase APD1 to 4 from Arabidopsis. They are involved in pollen mitosis II (PMII) regulation during male gametogenesis. This entry represents a functionally uncharacterised domain found towards the N-terminal of APD1-4 and in uncharacterised sequences, mainly from arthropods.
Pfam PF11120: Cellulose biosynthesis protein BcsF (family)
CBP_BcsF is a family of bacterial cellulose biosynthesis proteins. Cellulose is necessary for biofilm formation in bacteria.
Pfam PF10803: Spore germination GerPB (family)
Members of this family are required for formation of functionally normal spores. They may be involved in the establishment of spore coat structure or permeability.
Pfam PF00045: Hemopexin (repeat)
Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metallopeptidases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metallopeptidases (TIMPs).
Wikipedia: The hemopexin family is a family of evolutionarily related proteins. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metallopeptidases (TIMPs).
Pfam PF16512: p190-A and -B Rho GAPs FF domain (domain)
RhoGAP-FF1 is the FF domain of the Rho GTPase activating proteins (GAPs). These are the key proteins that make the switch between the active guanosine-triphosphate-bound form of Rho guanosine triphosphatases (GTPases) and the inactive guanosine-diphosphate-bound form. Rho guanosine triphosphatases (GTPases) are a family of proteins with key roles in the regulation of actin cytoskeleton dynamics.  The RhoGAP-FF1 region contains the FF domain that has been implicated in binding to the transcription factor TFII-I; and phosphorylation of Tyr308 within the first FF domain inhibits this interaction. The RhoGAPFF1 domain constitutes the first solved structure of an FF domain that lacks the first of the two highly conserved Phe residues, but the substitution of Phe by Tyr does not affect the domain fold.
Pfam PF09677: Type-F conjugative transfer system protein (TrbI_Ftype) (family)
This entry represents TrbI, an essential component of the F-type conjugative transfer system for plasmid DNA transfer that has been shown to be localized to the periplasm.
Pfam PF17637: Family of unknown function (DUF5516) (family)
This is a family of unknown function found in T7 viruses.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF22483: Mu transposase, C-terminal domain (domain)
Members of this family are found in various prokaryotic integrases and transposases. They adopt a beta-barrel structure with Greek-key topology according to or an OB fold according to ECOD.
Pfam PF16698: Membrane-proximal domain, switch, for ADAM17 (domain)
ADAM17_MPD is the membrane-proximal domain of a family of disintegrin and metalloproteinase domain-containing protein 17 found in metazoan species.  ADAM17 is a major sheddase that is responsible for the regulation of a wide range of biological processes, such as cellular differentiation, regeneration, and cancer progression. This MPD region acts as the sheddase switch. PDI or protein-disulfide isomerase interacts with ADAM17 and to down-regulate its enzymatic activity.  The interaction is directly with the MPD, the region of dimerisation and substrate recognition, where it catalyses an isomerisation of disulfide bridges within the thioredoxin motif CXXC. this isomerisation results in a major structural change between an active, open state and an inactive, closed state of the MPD. This change is thought to act as a molecular switch, allowing a global reorientation of the extracellular domains in ADAM17 and regulating its shedding activity.
Pfam PF05421: Protein of unknown function (DUF751) (family)
This family contains several plant, cyanobacterial and algal proteins of unknown function. The family is exclusively found in phototrophic organisms and may therefore play a role in photosynthesis (personal obs:Moxon SJ).
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF20897: Domain of unknown function (DUF6846) (domain)
This domain is found at the N-terminal end of Uncharacterized protein AF_2093 from Archaeoglobus fulgidus and similar proteins from archaea. Its function is unknown.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF24180: Effector protein Avr2 (family)
This entry represents Fusarium oxysporum Avr2 effector protein. Avr2 targets a conserved defense mechanism in different hosts. It also suppresses FLS2-mediated immune responses, such as growth inhibition, ROS production, MAPK activation and callose deposition following flagellin22 treatment. Avr2 folds into a beta-sandwich with some similarity to TRAF domains.
Pfam PF06844: Protein of unknown function (DUF1244) (family)
This family consists of several short bacterial proteins of around 100 residues in length. The function of this family is unknown.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF13008: Zinc-binding domain of Paramyxoviridae V protein (domain)
The Paramyxoviridae, which include such respiroviruses as para-influenzae and measles, produce phosphoproteins - protein P - that are integral to the polymerase transcription-replication complex. Protein P consists of two functionally distinct moieties, an N-terminal PNT, and a C-terminal PCT. The P gene region transcribes proteins from all three ORFs, and the V protein consists of the PNT moiety and a more C-terminal 2-zinc-binding domain. This conserved region consists of the two-zinc-binding section sandwiched between beta sheets 6 and 7 of the overall V protein. It is the binding of this core domain of V protein with the DDB1 protein (part of the ubiquitin-ligase complex) of eukaryotes which represents the key element of the virus-host protein interaction. In the Henipavirus family which includes Nipah and Hendra viruses, the V protein is able to block IFN (interferon) signalling by preventing IFN-induced STAT phosphorylation and nuclear translocation.  The P gene of morbillivirus is co-transcriptionally edited leading to a V protein being produced.
Pfam PF20725: Domain of unknown function (DUF6832) (domain)
This domain is functionally uncharacterised. It is predominantly found in eukaryotic sequences mostly from Alveolata. There are several highly conserved motifs: FGFNSFWS, FKxxxYD, PRxxY and YRC. Predictions of its structure suggest it folds into seven alpha helices.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF13701: Transposase DDE domain group 1 (domain)
Transposase proteins are necessary for efficient DNA transposition. This domain is a member of the DDE superfamily, which contain three carboxylate residues that are believed to be responsible for coordinating metal ions needed for catalysis.
Pfam PF19441: Astrotactin 1/2 N-terminal (domain)
This entry represents the N-terminal domain of Astrotactin (ASTN) proteins 1 and 2, which includes the transmembrane and cytosolic regions. These are vertebrate-specific proteins involved in neuronal migration during neurodevelopment. ASTN1 is a neuronal receptor required for neuroblasts migration along glial fibers, especially in the cerebellum. ASTN2 is an endosome membrane protein that binds ASTN1 and mediates its recycling by promoting ASTN1 internalisation and transport during its endocytosis.
Pfam PF08284: Retroviral aspartyl protease (domain)
Single domain aspartyl proteases from retroviruses, retrotransposons, and badnaviruses (plant dsDNA viruses). These proteases are generally part of a larger polyprotein; usually pol, more rarely gag. Retroviral proteases appear to be homologous to a single domain of the two-domain eukaryotic aspartyl proteases.
Pfam PF22280: VtrC lipocalin-like domain (domain)
This entry represents a lipocalin-like beta barrel domain found in the Vibrio parahaemolyticus VtrC protein. VtrC, along with VtrA and VtrB, are required for activating the virulence type III secretion system 2 in response to bile salts. The VtrA/VtrC complex activates VtrB in the presence of bile salts. The crystal structure of the periplasmic domains of the VtrA/VtrC heterodimer reveals a beta-barrel with a hydrophobic inner chamber.
Pfam PF09724: Sister chromatid cohesion protein Dcc1 (family)
Sister chromatid cohesion protein Dcc1 is a component of the Ctf18-RFC complex. This complex is required for the efficient establishment of chromosome cohesion during S-phase and for loading the replication clamp Pol30/PCNA, which functions in DNA replication and repair. Ctf18-RFC loads PCNA onto DNA in an ATP-dependent manner. It may also have PCNA-unloading activity.
Pfam PF17888: Carmil pleckstrin homology domain (domain)
This is a non-canonical pleckstrin homology (PH) domain connected to a 16-leucine-rich repeat domain found in CARMIL (CP Arp2/3 complex myosin-I linker) proteins. The PH domain is interconnected with an N-terminal helix (N-helix), residues 10-20 and a C-terminal linker (Linker), residues 129-147 in [swissprot:Q6EDY6] . Structural and functional studies indicate that the PH domain involved in direct binding to the PM (plasma membrane) and a HD (helical domain) responsible for antiparallel dimerization and enhancement of CARMIL's membrane-binding activity. Furthermore, it appears that CARMIL's PH domain mediates non-specific binding to the membrane, in contrast to other PH domains that bind polyphosphorylated phosphatidylinositides, which are thought to function as signalling lipids.
Pfam PF11825: Nuclear/hormone receptor activator site AF-1 (family)
Nuclear receptors (NRs) are a family of ligand-inducible transcription factors, and, like other transcription factors, they contain a distinct DNA binding domain that allows for target gene recognition and several activation domains that possess the ability to activate transcription. One of these activation domains is at the N-terminal, although there are two distinct motifs within this domain, between residues 20-36 and between 74 and the end of this domain, which are the binding regions. One of the co-activators is TIF1beta, which appears to bind at the first motif.
Pfam PF13873: Myb/SANT-like DNA-binding domain (domain)
This presumed domain appears to be related to other Myb/SANT like DNA binding domains.  This family is greatly expanded in arthropods and higher eukaryotes.
Pfam PF07602: Protein of unknown function (DUF1565) (repeat)
These proteins share a region of homology in their N termini, and are found in several phylogenetically diverse bacteria and in the archaeon Methanosarcina acetivorans. Some of these proteins also contain characterised domains such as [pfam:PF00395] (e.g. [swissprot:Q8YWJ6]) and [pfam:PF03422] (e.g. [swissprot:Q9FBS2]).
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF20080: ALTTAQ repeat (repeat)
This repeat is called after the short repeat ALTTAQ found in uncharacterised proteins from Proteobacteria, some eukaryotes and viruses, and it is functionally uncharacterised.
Pfam PF17971: Leukemia inhibitory factor receptor D2 domain (domain)
This is the D2 domain in cytokine-binding module 1 (CBM1) found in Leukemia inhibitory factor receptor (LIFR) and OSM receptors (OSMR). LIFR has an extracellular region with a modular structure containing two cytokine-binding modules (CBM) separated by an Ig-like domain and followed by three membrane-proximal fibronectin type-III (FNIII) domains. The D2 domain in CBM1 shows structural similarity to the corresponding CBM domains of both gp130 and IL-6Ralpha because it contains conserved structural features like the WSXWS motif. The WSXWS motif in cytokine receptors is a molecular switch involved in receptor activation.
Pfam PF10922: Bacteriophage T7-like, gene 1.2 (family)
The T7-like bacteriophage gene 1.2 protein is an inhibitor of the Escherichia coli dGTP triphosphohydrolase (dGTPase) and is implicated in DNA replication.
Pfam PF16328: Domain of unknown function (DUF4961) (family)
This small family consists of several uncharacterized proteins around 350 residues in length and is mainly found in various Bacteroides species. The function of this protein is unknown.
Pfam PF21335: Metazoan delta subunit of F1F0-ATP synthase, C-terminal domain (domain)
F-type ATPases consist of two structural domains, F1 containing the extramembraneous catalytic core, and F0 which contains the membrane proton channel. This entry includes ATP synthase subunit delta from animals (called epsilon in bacteria or chloroplast ATPase), which interacts with subunit C from F0 which is important for connecting the rotor of F1 (gamma subunit) to the rotor of F0 C subunit). This entry represents the C-terminal alpha-helical domain which is likely to act as an inhibitor of ATPase activity.
Pfam PF23194: NOMO fifth transthyretin-like domain (domain)
This domain is found in the family of human Nodal modulators NOMO1, NOMO2, NOMO3 and in other related proteins. The Nodal modulators are components of the multi-pass translocon (MPT) complex that mediates insertion of multi-pass membrane proteins into the membrane lipid bilayer. They play important role in the protein topogenesis and cells lacking these components show reduced multipass protein stability. The domain represented by this entry has a weak sequence similarity to Transthyretin-like domains and it is predicted to adopt similar structure that consists of seven-stranded beta-sandwich. Nodal modulators are predicted to contain a tandem of twelve Transthyretin-like domains and this domain is the fifth in the tandem.
Pfam PF10868: Cysteine-rich antifungal protein 2, defensin-like (domain)
This is a family of plant antifungal proteins. It has insecticidal and antifungal activity against certain plant pathogens.
Pfam PF04802: Phosphatase 4 regulatory subunit 3 (repeat)
This entry represents the Serine/threonine-protein phosphatase 4 regulatory subunit 3 (also known as SMEK homologue) PP4R3, which forms a complex with the phosphatase 4 catalytic subunit (PP4c), localising it to the DNA damage repair machinery and regulates its activity. PP4c is involved in developmental progression, chemotaxis, expression of stress response genes and cell movement.  These proteins contain an N-terminal EVH1 domain and this alpha solenoid region.
Pfam PF17497: Family of unknown function (DUF5432) (family)
This is a family of unknown function found in Orthopoxvirus.
Pfam PF20015: vWA-MoxR associated protein middle region (VMAP-M) 12 (family)
Highly variable central region of the vWA-MoxR associated protein (VMAP) of the classical ternary system (vWA-MoxR-VMAP) in NTP-dependent conflict systems. VMAP-Ms may be involved in sensing of invasive entities.
Pfam PF08272: Topoisomerase I zinc-ribbon-like (domain)
Some Proteobacteria topoisomerase I contain two zinc-ribbon-like domains at the C-terminus that structurally homologous to [pfam:PF01396]. However, this domain no longer bind zinc.  Indeed, only one of the four cysteine residues remains.