SII-SWORD/CoKE huggingface dataset:
Pfam PF10105: Uncharacterized protein conserved in bacteria (DUF2344) (family)
This domain, found in various hypothetical bacterial proteins and Radical Sam domain proteins, has no known function. This domain is distantly related to tRNA pseudouridine synthases, suggesting this family may carry out a function related to RNA modification. But this family appears to lack the catalytic aspartate found in pseudouridine synthases.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF23741: Domain of unknown function (DUF7164) (domain)
This domain is found either standalone or in tandem in uncharacterised eukaryotic proteins. It has a weak sequence similarity to Nucleotide-diphospho-sugar transferases, in particular to Glycolipid 2-alpha-mannosyltransferases ([pfam:PF01793]) and is predicted to adopt similar structure.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF08675: RNA binding domain (domain)
This domain corresponds to the RNA binding domain of Poly(A)-specific ribonuclease (PARN).
Pfam PF05116: Sucrose-6F-phosphate phosphohydrolase (family)
This family consists of Sucrose-6F-phosphate phosphohydrolase proteins found in plants and cyanobacteria. Sucrose-6(F)-phosphate phosphohydrolase catalyses the final step in the pathway of sucrose biosynthesis.
Pfam PF16764: Sharpin PH domain (domain)
This PH domain is found at the N-terminus of sharpin and is involved in dimerisation.
Pfam PF15463: Extracellular mutant protein 11 (family)
ECM11 is a family of largely fungal proteins. ECM11 interacts with Cdc6, an essential protein involved in the initiation of DNA replication, and is a nuclear protein involved in maintaining chromatin structure. It was previously identified as a protein involved in yeast cell wall biogenesis and organisation, but is also found to be required in meiosis where its function is related to DNA replication and crossing-over.
Pfam PF14810: Patch-forming domain C2 of tRNA-guanine transglycosylase (domain)
Domain C2 of tRNA-guanine transglycosylase is formed by a four-stranded anti-parallel beta-sheet lined with two alpha helices. It has conserved basic residues on the surface of the beta-sheets as does the C-terminal domain PUA, [pfam:PF01472]. The catalytic domain, TGT has conserved basic residues on the outer surface of the N-terminal three-stranded beta sheet, which closes the barrel, and it is postulated that these basic residues from the three domains form a continuous, positively charged patch to which the tRNA binds.
Pfam PF17378: Meiotic recombination protein REC104 (family)
REC104 is one of several meiosis specific genes required for generating meiotic DSBs (double strand breaks). It is suggested that Rec102 and Rec104 directly promote DSB formation as part of a multiprotein complex with Spo11. Rec102 and Rec104 are mutually dependent for proper sub-cellular localization, and share a requirement for Spo11 and Ski8 for their recruitment to meiotic chromosomes. Moreover, Rec102 is required for Rec104 to accumulate to normal steady-state levels and to be properly phosphorylated. It is likely that Rec102 and Rec104 move freely in and out of the nucleus but are most stably sequestered there only when they can form a complex on chromosomes. This domain family is found on Rec104 proteins in yeast.
Pfam PF04494: WD40 associated region in TFIID subunit, NTD2 domain (family)
This region is an all-alpha domain associated with the WD40 helical bundle of the TAF5 subunit of transcription factor TFIID. The domain has distant structural similarity to RNA polymerase II CTD interacting factors. It contains several conserved clefts that are likely to be critical for TFIID complex assembly.  The TAF5 subunit is present twice in the TFIID complex and is critical for the function and assembly of the complex, and the NTD2 and N-terminal domain is crucial for homodimerisation.
Pfam PF11027: Protein of unknown function (DUF2615) (family)
This small. approximately 100 residue, family is conserved from worms to humans. It is cysteine-rich with a characteristic FDxCEC sequence motif. The function is not known.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF10615: Domain of unknown function (DUF2470) (domain)
This domain is found in a group of putative heme-iron utilisation proteins, such as HugZ. It can also be found in C-terminal of the glutamyl-tRNA reductase-binding (GluTRBP) protein from Arabidopsis. GluTRBP is involved in the regulation of glutamyl-tRNA reductase (GluTR) which is important for the synthesis and distribution of 5-aminolevulinate, a precursor in heme and chlorophyll biosynthesis. GluTRBP is necessary for efficient photosynthetic electron transport in chloroplasts.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF20102: Family of unknown function (DUF6492) (family)
This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and eukaryotes. Proteins in this family are typically between 305 and 329 amino acids in length.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF07588: Protein of unknown function (DUF1554) (family)
A family of proteins identified in Leptospira interrogans.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF22838: COMMD8, helical N-terminal domain (domain)
This entry represents the alpha-helical N-terminal domain (HN) of COMMD8, one of the subunits of the CCC complex (Commander complex), which regulates the Retromer-independent retrieval and recycling of hundreds of proteins including integrins and lipoprotein receptors.
Pfam PF14306: PUA-like domain (domain)
This PUA like domain is found at the N-terminus of ATP-sulfurylase enzymes.
Pfam PF14502: Helix-turn-helix domain (family)
This helix-turn-helix domain is found in uncharacterized protein YhfZ from E. coli and in other bacterial proteins.
Pfam PF05873: ATP synthase D chain, mitochondrial (ATP5H) (family)
This family consists of several ATP synthase D chain, mitochondrial (ATP5H) proteins. Subunit d has no extensive hydrophobic sequences, and is not apparently related to any subunit described in the simpler ATP synthases in bacteria and chloroplasts.
Wikipedia: The human gene ATP5PD encodes subunit d of the peripheral stalk part of the enzyme mitochondrial ATP synthase.
Pfam PF15439: Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter (family)
NYAP_N is an N-terminal family of eukaryotic proteins that are substrates of tyrosine kinase in the brain. When first identified, the family members were referred to as unconventional myosin XVI, or Myr 8. However, proteins have now been identified as being integrally involved in neuronal function and morphogenesis. The family is involved in both the activation of phosphoinositide 3-kinase (PI3K) and the recruitment of the downstream effector WAVE complex to the close vicinity of PI3K; it also appears to regulate the brain size and neurite outgrowth in mice.
Pfam PF02565: Recombination protein O C terminal (family)
Recombination protein O (RecO) is involved in DNA repair and [pfam:PF00470] pathway recombination.
Pfam PF03803: Scramblase (domain)
Scramblase is palmitoylated and contains a potential protein kinase C phosphorylation site.  Scramblase exhibits Ca2+-activated phospholipid scrambling activity in vitro. There are also possible SH3 and WW binding motifs. Scramblase is involved in the redistribution of phospholipids after cell activation or injury.
Wikipedia: Scramblase is a protein responsible for the translocation of phospholipids between the two monolayers of a lipid bilayer of a cell membrane. In humans, phospholipid scramblases (PLSCRs) constitute a family of five homologous proteins that are named as hPLSCR1–hPLSCR5. Scramblases are members of the general family of transmembrane lipid transporters known as flippases. Scramblases are distinct from flippases and floppases. Scramblases, flippases, and floppases are three different types of enzymatic groups of phospholipid transportation enzymes. The inner-leaflet, facing the inside of the cell, contains negatively charged amino-phospholipids and phosphatidylethanolamine. The outer-leaflet, facing the outside environment, contains phosphatidylcholine and sphingomyelin. Scramblase is an enzyme, present in the cell membrane, that can transport (scramble) the negatively charged phospholipids from the inner-leaflet to the outer-leaflet, and vice versa.
Pfam PF04118: Dopey, N-terminal (repeat)
DopA is the founding member of the Dopey family and is required for correct cell morphology and spatiotemporal organisation of multicellular structures  in the filamentous fungus Aspergillus nidulans. DopA homologues are found in mammals.  S. cerevisiae DOP1 is essential for viability and, affects cellular morphogenesis.
Pfam PF17828: N-terminal domain in fatty acid synthase subunit beta (domain)
This entry represents the N-terminal domain found in fatty acid synthase proteins such as [swissprot:P07149].
Pfam PF15016: Domain of unknown function (DUF4520) (family)
This family of proteins is found in eukaryotes. Proteins in this family are typically between 197 and 638 amino acids in length.This is the C-terminal domain of the member proteins.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF00876: Innexin (family)
This family includes the Drosophila proteins Ogre and shaking-B, and the C. elegans proteins Unc-7 and Unc-9. Members of this family are integral membrane proteins which are involved in the formation of gap junctions. This family has been named the Innexins.
Wikipedia: Innexins are transmembrane proteins that form gap junctions in invertebrates. Gap junctions are composed of membrane proteins that form a channel permeable to ions and small molecules connecting the cytoplasm of adjacent cells. Although gap junctions provide similar functions in all multicellular organisms, it was not known what proteins invertebrates used for this purpose until the late 1990s. While the connexin family of gap junction proteins was well-characterized in vertebrates, no homologues were found in non-chordates.
Pfam PF12454: GPI-anchored cell wall organization protein (family)
This domain family is found in eukaryotes, and is approximately 40 amino acids in length. Ecm33 is an essential cell wall component and is important for cell wall integrity.
Pfam PF21332: AmiR, N-terminal (domain)
This is the N-terminal domain of Aliphatic amidase regulator (AmiR) which acts as a transcriptional antitermination factor. It positively controls AmiE, the gene for aliphatic amidase.
Pfam PF17425: Arylsulfotransferase Ig-like domain (domain)
This family consists of several bacterial Arylsulfotransferase proteins. Arylsulfotransferase (ASST) transfers a sulfate group from phenolic sulfate esters to a phenolic acceptor substrate.  This domain has an Ig-like fold.
Wikipedia: An aryl sulfotransferase is an enzyme that 
transfers a sulfate group from phenolic sulfate esters to a phenolic acceptor substrate.3'-phosphoadenylyl sulfate + a phenol  adenosine 3',5'-bisphosphate + an aryl sulfate
Pfam PF14536: Domain of unknown function (DUF4441) (family)
This family is largely made up of uncharacterised proteins from the Ciliophora.  The function is not known.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF18228: CdiI N-terminal domain (domain)
This is the N-terminal domain of Contact-dependent growth inhibition immunity (CdiI) proteins present in Enterobacter cloacae. CdiI proteins neutralize CdiA-CT toxins to protect toxin-producing cells from auto-inhibition. Structural homology searches reveal that Enterobacter cloacae's CdiI is most similar to the Whirly family of single-stranded DNA-binding protein.
Pfam PF19483: Family of unknown function (DUF6019) (family)
This family of proteins is functionally uncharacterised. This family of proteins is found in Clostridia. Proteins in this family are typically between 51 and 67 amino acids in length and have a single transmembrane helix.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF01766: Birnavirus VP2 protein (family)
VP2 is the major structural protein of birnaviruses. The large RNA segment of birnaviruses codes for a polyprotein (N-VP2-VP4-VP3-C).
Wikipedia: Birnaviridae is a family of double-stranded RNA viruses. Salmonid fish, birds and insects serve as natural hosts. There are currently 11 species in this family, divided among seven genera. Diseases associated with this family include infectious pancreatic necrosis in salmonid fish, which causes significant losses to the aquaculture industry, with chronic infection in adult salmonid fish and acute viral disease in young salmonid fish.
Pfam PF18152: DAHP synthase ferredoxin-like domain (domain)
This domain is found in 3-Deoxy-d-arabino-heptulosonate-7-phosphate synthase (DAHPS) present in Thermotoga maritime. DAHPS catalyzes the first reaction of the aromatic biosynthetic pathway in bacteria, fungi, and plants, the condensation of PEP and E4P with the formation of DAHP. The domain is ferredoxin-like and is thought to play a critical role in feedback regulation of the enzyme.
Pfam PF22300: NGO_1070-like (domain)
This protein family includes the uncharacterised protein NGO_1070 from Neisseria gonorrhoeae ([swissprot:Q5F7U7]) and similar proteins found in proteobacteria. NGO_1070 adopts a beta barrel fold. Its function is unknown.
Pfam PF07399: Putative Na+/H+ antiporter (family)
This family consists of several hypothetical bacterial proteins of around 440 residues in length. The function of this family is unknown. Many members carry 11 or 12 transmembrane regions, suggesting that they might be transporters. One family member, UniProtKB:Q821X2 is classified by TCDB as being an NhaE type of Na+/H+ antiporter.
Pfam PF03238: ESAG protein (family)
Expression-site-associated gene (ESAG) proteins are thought  to be involved in VSG activation. This family includes ESAG 117A [swissprot:P04477] as well as ESAG IM Swiss: Q26705.
Pfam PF10657: Photosystem P840 reaction centre protein PscD (family)
The photosynthetic reaction centres (RCs) of aerotolerant organisms contain a heterodimeric core, built up of two strongly homologous polypeptides each of which contributes five transmembrane peptide helices to hold a pseudo-symmetric double set of redox components. Two molecules of PscD are housed within a subunit. PscD may be involved in stabilising the PscB component since it is found to co-precipitate with FMO (Fenna-Mathews-Olson BChl a-protein) and PscB. It may also be involved in the interaction with ferredoxin.
Pfam PF18945: EvpB/VC_A0108, tail sheath gpW/gp25-like domain (domain)
EvpB is a family of Gram-negative probable type VI secretion system components of the tail sheath. They have been known as COG:COG3517.  These sheath-components, of which there are many copies in the sheath, are also variously referred to as VipA/VipB and TssB/TssC. On contact with another bacterial cell the sheath contracts and pushes the puncturing device and tube through the cell envelope and punches the target bacterial cell. This entry represents the gpW/gp25-like domain.
Pfam PF07716: Basic region leucine zipper (coiled_coil)
The basic-leucine zipper (bZIP) domain transcription factors  of eukaryotic are proteins that contain a basic region mediating sequence-specific DNA-binding followed by a leucine zipper region required for dimerisation.

Several structure of bZIP have been solved. The basic region and the leucine zipper form a contiguous Î±-helix where the four hydrophobic residues of the leucine zipper are oriented on one side. This conformation allows dimerisation in parallel and it bends the helices so that the newly functional dimer forms a flexible fork where the basic domains, at the N-terminal open end, can then interact with DNA. The two leucine zipper are therefore oriented perpendicular to the DNA .
Wikipedia: The Basic Leucine Zipper Domain is found in many DNA binding eukaryotic proteins. One part of the domain contains a region that mediates sequence specific DNA binding properties and the leucine zipper that is required to hold together (dimerize) two DNA binding regions. The DNA binding region comprises a number of basic amino acids such as arginine and lysine. Proteins containing this domain are transcription factors.
Pfam PF15526: Novel toxin 21 (family)
Bacterial genomes and plasmids encode a variety of peptide and protein toxins that mediate inter-bacterial competition. Bacteriocins are diffusible proteins that parasitize cell-envelope proteins to enter and kill bacteria. Contact-dependent growth inhibition (CDI) is one mechanism of inter-bacterial competition. Novel Toxin 21 (alternatively 16S rRNA endonuclease CdiA) belongs to a family of prokaryotic polymorphic toxin systems implicated in intra-specific conflicts. This RNase toxin found in bacterial polymorphic toxin systems, is proposed to adopt the BECR (Barnase-EndoU-ColicinE5/D-RelE) fold, with two conserved lysine residues and [DS]xDxxxH, RxG[ST] and RxxD motifs. In bacterial polymorphic toxin systems, the toxin is usually exported by the type 2, type 4, type 5 or type 7 secretion systems. This is also referred to as the E. cloacae CdiAC. The CdiAC proteins carry a variety of sequence-diverse C-terminal domains, which represent a collection of distinct toxins. Many CdiA-CT toxins have nuclease activities. In accord with the structural homology, CdiA-CT cleaves 16S rRNA at the same site as colicin E3 and this nuclease activity is responsible for growth inhibition.
Pfam PF20902: C-X-C motif chemokine 16 domain (domain)
This family includes the CXCL16 protein, which acts as a scavenger receptor on macrophages, which specifically binds to OxLDL (oxidized low density lipoprotein). This entry covers the CXC chemokine-like domain.
Pfam PF09533: Predicted lipoprotein of unknown function (DUF2380) (family)
This family consists of at least 9 paralogs in Myxococcus xanthus, a member of the Deltaproteobacteria. One appears truncated toward the N-terminus; the others are predicted lipoproteins. The function is unknown.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF06456: Arfaptin-like domain (domain)
Arfaptin interacts with ARF1, a small GTPase involved  in vesicle budding at the Golgi complex and immature secretory granules.  The structure of arfaptin shows that upon binding to a small GTPase, arfaptin forms an elongated, crescent-shaped dimer of three-helix  coiled-coils. The N-terminal region of ICA69 is similar to arfaptin.
Wikipedia: In molecular biology, the arfaptin domain is a protein domain which interacts with ARF1, a small GTPase involved in vesicle budding at the Golgi complex and immature secretory granules. The structure of arfaptin shows that upon binding to a small GTPase, arfaptin forms an elongated, crescent-shaped dimer of three-helix coiled-coils. The N-terminal region of ICA69 is similar to arfaptin.
Pfam PF11457: Protein of unknown function (DUF3021) (family)
This is a bacterial family of uncharacterised proteins.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF18455: Gamma-aminobutyric acid type B receptor subunit 2 coiled-coil domain (coiled_coil)
This is the intracellular coiled-coil domain found in Gamma-aminobutyric acid type B receptor subunit 2 (GBR2). The coiled-coil complex between the GABAB receptor subunits GBR1 and GBR2 is responsible for facilitating the surface transport of the intact receptor. Disruption of the hydrophobic coiled-coil interface with single mutations in either subunit impairs surface expression of GBR1, confirming that the coiled-coil interaction is required to inactivate the adjacent ER retention signal of GBR1.
Pfam PF14789: Tetrahydrodipicolinate N-succinyltransferase middle (domain)
This is the middle domain of 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase.