SII-SWORD/CoKE huggingface dataset:
Pfam PF16761: Transcription-silencing protein, cryptic loci regulator Clr2 (family)
Clr2_transil is a domain carrying the first and second of three regions on Clr2 that are necessary for transcriptional silencing by the protein.  Clr2 is a protein in the SHREC complex that is a crucial factor required for heterochromatin formation and it plays a major role in mating-type and rDNA silencing. The third region is family [pfam:PF10383].
Pfam PF05706: Cyclin-dependent kinase inhibitor 3 (CDKN3) (domain)
This family consists of cyclin-dependent kinase inhibitor 3 or kinase associated phosphatase proteins from several mammalian species. The cyclin-dependent kinase (Cdk)-associated protein phosphatase (KAP) is a human dual specificity protein phosphatase that dephosphorylates Cdk2 on threonine 160 in a cyclin-dependent manner.
Pfam PF18920: Domain of unknown function (DUF5671) (family)
This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and archaea. Proteins in this family are typically between 168 and 339 amino acids in length. These proteins are likely to be integral membrane proteins.
Pfam PF09419: Mitochondrial PGP phosphatase (family)
This is a family of proteins that acts as a mitochondrial phosphatase in cardiolipin biosynthesis. Cardiolipin is a unique dimeric phosphoglycerolipid predominantly present in mitochondrial membranes. The inverted phosphatase motif includes the highly conserved DKD triad.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF14269: Arylsulfotransferase (ASST) (repeat)
This entry represents a group of arylsulfotransferase-like proteins from eukaryotes, archaea and bacteria.
Wikipedia: An aryl sulfotransferase is an enzyme that 
transfers a sulfate group from phenolic sulfate esters to a phenolic acceptor substrate.3'-phosphoadenylyl sulfate + a phenol  adenosine 3',5'-bisphosphate + an aryl sulfate
Pfam PF12836: Helix-hairpin-helix motif (domain)
The HhH domain is a short DNA-binding domain.
Pfam PF04986: Putative transposase (family)
Transposases are needed for efficient transposition of the insertion sequence or transposon DNA. This family includes transposases IS1294 and IS801. This is a rolling-circle transposase.
Pfam PF18192: DNTTIP1 dimerisation domain (domain)
This is the N-terminal domain of DNTTIP1, a protein that forms part of a novel histone deacetylase complex present in Homo sapiens. Histone deacetylase complexes comprise DNTTIP1, histone deacetylase (HDAC) and the repressor protein MIDEAS. The acetylation of histone tails plays a critical role in determining the accessibility of chromatin to transcriptional regulators and RNA polymerase complexes. This N-terminal domain is responsible for dimerization of histone deacetylase 1(HDAC1). The N-terminal domain also interacts and mediates the assembly of the HDAC1- MIDEAS complex.
Pfam PF05352: Phage Connector (GP10) (family)
The head-tail connector of bacteriophage 29 is composed of 12 36  kDa subunits with 12 fold symmetry. It is the central component  of a rotary motor that packages the genomic dsDNA into pre-formed  proheads. This motor consists of the head-tail connector, surrounded  by a 29-encoded, 174-base, RNA and a viral ATPase protein.
Pfam PF03144: Elongation factor Tu domain 2 (domain)
Elongation factor Tu consists of three structural domains, this is the second domain. This domain adopts a beta barrel structure. This the second domain is involved in binding to charged tRNA. This domain is also found in other proteins such as elongation factor G and translation initiation factor IF-2. This domain is structurally related to [pfam:PF03143], and in fact has weak sequence matches to this domain.
Wikipedia: EF-Tu is a prokaryotic elongation factor responsible for catalyzing the binding of an aminoacyl-tRNA (aa-tRNA) to the ribosome. It is a G-protein, and facilitates the selection and binding of an aa-tRNA to the A-site of the ribosome. As a reflection of its crucial role in translation, EF-Tu is one of the most abundant and highly conserved proteins in prokaryotes. It is found in eukaryotic mitochondria as TUFM.
Pfam PF09016: Pas factor saposin fold (domain)
Members of this family adopt a compact structure comprising five alpha helices. Charged and polar residues are exposed mostly on the surface, while most of the hydrophobic residues are buried inside the hydrophobic core of the helical bundle. The precise function of this domain is unknown, but it is has been shown to induce secretion of periplasmic proteins, especially collagenase.
Pfam PF15076: Domain of unknown function (DUF4543) (family)
This family of proteins is found in eukaryotes. Proteins in this family are typically between and 90 amino acids in length. The human member of this family is C17orf67.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF24956: Mechanosensitive ion channel protein 2/3 C-terminal (domain)
This entry represents the C-terminal domain of Mechanosensitive ion channel proteins 2 and 3 from Arabidopsis and related plant sequences. These channels open in response to stretch forces in the membrane lipid bilayer and control plastid size, shape, and perhaps division during normal plant development by altering ion flux in response to changes in membrane tension. They act as a component of the chloroplast division machinery. These channels are closely related to MscS from bacteria.
Pfam PF12488: Protein of unknown function (DUF3704) (family)
This domain family is found in eukaryotes, and is approximately 30 amino acids in length.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF16478: Domain of unknown function (DUF5055) (family)
This family consists of several uncharacterized proteins around 100 residues in length and is mainly found in butyrate-producing bacteriums. The function of this family is unknown.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF22179: RickCE-like, catalytic domain (domain)
This entry represents the catalytic domain of a subset of ubiquitin-like proteases from the CE clan, including RickCE from Rickettsia.
Pfam PF22385: CRISPR-associated endonuclease Cas9, C-terminal domain (domain)
This domain is found at the C-terminal end of CRISPR-associated endonuclease Cas9 from the gammaproteobacteria Francisella tularensis.
Pfam PF03289: Poxvirus protein I1 (family)
This entry represents a family of proteins from poxvirus, including the vaccinia virus I1L (Late) encoded protein, which is also called Telomere-binding protein OPG077. It is a DNA-binding protein which binds to the hairpin form of the viral telomeric sequence. Required for the production of mature virions (MV) .
Pfam PF22185: Uncharacterized protein AF_0924 (domain)
This entry represents the AF_0924 protein from Archaeoglobus fulgidus. The structure of this protein is composed of three alpha helices and three strands.
Pfam PF03247: Prothymosin/parathymosin family (family)
Prothymosin alpha and parathymosin are two ubiquitous small acidic nuclear proteins that are thought to be involved in cell cycle progression, proliferation, and cell differentiation.
Pfam PF08938: HBS1 N-terminus (domain)
This domain is found at the N-terminus of HBS1 proteins. It interacts with the ribosomal protein rpS3 at the mRNA entry site.
Pfam PF08943: CsiD (domain)
This family consists of various bacterial proteins pertaining to the non-haem Fe(II)-dependent oxygenase family. Exact function is unknown, but a putative role includes involvement in the control of utilisation of gamma-aminobutyric acid.
Pfam PF04754: Putative transposase, YhgA-like (family)
This family of putative transposases includes the YhgA sequence from Escherichia coli ([swissprot:P31667]) and several prokaryotic homologues.
Pfam PF05428: Corticotropin-releasing factor binding protein N-terminal domain (domain)
This entry corresponds to the N-terminal domain from eukaryotic corticotropin-releasing factor binding proteins (CRF-BP or CRH-BP). Corticotropin-releasing hormone (CRH) plays multiple roles in vertebrate species. In mammals, it is the major hypothalamic releasing factor for pituitary adrenocorticotropin secretion, and is a neurotransmitter or neuromodulator at other sites in the central nervous system. In non-mammalian vertebrates, CRH not only acts as a neurotransmitter and hypophysiotropin, it also acts as a potent thyrotropin-releasing factor, allowing CRH to regulate both the adrenal and thyroid axes, especially in development. CRH-BP is thought to play an inhibitory role in which it binds CRH and other CRH-like ligands and prevents the activation of CRH receptors. There is however evidence that CRH-BP may also exhibit diverse extra and intracellular roles in a cell specific fashion and at specific times in development.
Wikipedia: Corticotropin-releasing hormone binding protein (CRH-BP) binds corticotropin-releasing hormone (CRH) and several related peptide hormones. It is an ancient, highly conserved protein whose origin predates the divergence of protostomes and deuterostomes.
Pfam PF06890: Bacteriophage Mu Gp45, N-terminal (domain)
This entry represents the N-terminal domain of Bacteriophage Mu Gp45 and related proteins from both phages and bacteria. Gp45 is a component of the baseplate that forms a central needle-like spike used to puncture the host cell membrane for tube insertion during virus entry. It serves as the distal plug of tail tube channel and might regulate the process of the phage DNA and protein ejection into the host cell. According to structure predictions and comparison, this domain may adopt and OB-fold.
Pfam PF25012: Family of unknown function (DUF7786) (family)
This family represents a group of uncharacterised proteins from arthropod-infecting viruses.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF05435: Phi-29 DNA terminal protein GP3 (family)
This family consists of DNA terminal protein GP3 sequences from Phi-29 like bacteriophages. DNA terminal protein GP3 is linked to the 5' ends of both strands of the genome through a phosphodiester bond between the beta-hydroxyl group of a serine residue and the 5'-phosphate of the terminal deoxyadenylate. This protein is essential for DNA replication and is involved in the priming of DNA elongation.
Pfam PF14013: MT0933-like antitoxin protein (family)
This family of proteins contains the MT0933 protein [swissprot:O05901] which has been identified as an antitoxin to /protein MT0934. This family of proteins is found in bacteria. Proteins in this family are typically between 61 and 90 amino acids in length.
Pfam PF02991: Autophagy protein Atg8 ubiquitin like (domain)
Light chain 3 is proposed to function primarily as a subunit of microtubule associated proteins 1A and 1B and that its expression may regulate microtubule binding activity. Autophagy is generally known as a process involved in the degradation of bulk cytoplasmic components that are non-specifically sequestered into an autophagosome, where they are sequestered into double-membrane vesicles and delivered to the degradative organelle, the lysosome/vacuole, for breakdown and eventual recycling of the resulting macromolecules. The yeast proteins are involved in the autophagosome, and Atg8 binds Atg19, via its N-terminus and the C-terminus of Atg19.
Pfam PF13449: Esterase-like activity of phytase (repeat)
This is a repeated domain that carries several highly conserved Glu and Asp residues indicating the likelihood that the domain incorporates the enzymic activity of the PLC-like phospho-diesterase part of the proteins.
Pfam PF20498: Family of unknown function (DUF6728) (family)
This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 45 and 78 amino acids in length.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF04327: Cysteine protease Prp (family)
This is a family of cysteine protease that are found to cleave the N-terminus extension of ribosomal subunit L27 in eubacteria. Proteins in this family are distinguished by a pair of invariant histidine and cysteine residues with conserved spacing that form the classic catalytic dyad of a cysteine protease.
Pfam PF20337: Family of unknown function (DUF6632) (family)
This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and eukaryotes. Proteins in this family are typically between 127 and 139 amino acids in length.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF03453: MoeA N-terminal region (domain I and II) (family)
This family contains two structural domains. One of these contains the conserved DGXA motif. This region is found in proteins involved in biosynthesis of molybdopterin cofactor however the exact molecular function of this region is uncertain.
Pfam PF09518: HindIII restriction endonuclease (family)
This family includes the HindIII (recognises and cleaves A^AGCTT) restriction endonuclease.
Wikipedia: HindIII (pronounced "Hin D Three") is a type II site-specific deoxyribonuclease restriction enzyme isolated from Haemophilus influenzae that cleaves the DNA palindromic sequence AAGCTT in the presence of the cofactor Mg2+ via hydrolysis.
Pfam PF21020: Spectrin-like repeat (domain)
This entry represents a spectrin repeat found in the plectin protein.
Pfam PF24211: Family of unknown function (DUF7432) (family)
This entry represents a family of uncharacterised phage proteins that are composed of two small domains connected by an alpha helix. Structure prediction suggests that these proteins may homodimerise or tetramerise. These proteins are primarily found in Gordonia phage.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF13998: MgrB protein (family)
The MgrB protein is a short lipoprotein.  The mgrB gene has a mg2+ responsive promoter. Deletion of mgrB results in a potent increase in PhoP-regulated transcription. The PhoQ/PhoP signaling system responds to low magnesium and the presence of certain cationic antimicrobial peptides. Over-expression of mgrB decreased transcription at both high and low concentrations of magnesium. Localization and bacterial two-hybrid studies suggest that MgrB resides in the inner-membrane and interacts directly with PhoQ. This domain family is found in bacteria, and is approximately 40 amino acids in length. There are two conserved sequence motifs: CDQ and GIC.
Pfam PF18523: Sld3 N-terminal domain (domain)
Sld3 is conserved in yeast and fungi, and treslin, also known as Ticrr, has been identified as the functional counterpart of Sld3 in metazoans. However, they differ in size and amino acid sequence. Yeast Sld3 and its metazoan counterpart treslin are the hub proteins mediating protein associations critical for formation of the helicase. This entry represents the N-terminal domain of Sld3 which is shown to bind to the N-terminal domain of Sld7. This domain adopts a Ku70-like beta-barrel fold which in Sld3 is truncated, containing five beta-strands.
Pfam PF20529: Family of unknown function (DUF6744) (family)
This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 290 and 350 amino acids in length.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF12638: Staygreen protein (domain)
This family of proteins have been implicated in chlorophyll degradation. Intriguingly members of this family are also found in non-photosynthetic bacteria.
Pfam PF07501: G5 domain (domain)
This domain is found in a wide range of extracellular proteins. It is found tandemly repeated in up to 8 copies.  It is found in the N-terminus of peptidases belonging to the M26 family which cleave human IgA.  The domain is also found in proteins involved in metabolism of bacterial cell walls suggesting this domain may have an adhesive function.
Pfam PF12243: CTD kinase subunit gamma CTK3 (repeat)
The C-terminal domain kinase (CTDK-1), is a three-subunit complex comprised of Ctk1, Ctk2, and Ctk3, that plays a key role in regulation of transcription and translation and in coordinating these two processes. Both Ctk2 and Ctk3 are regulated at the level of protein turnover, and are unstable proteins processed through a ubiquitin-proteasome pathway. Their physical interaction is required to protect both subunits from degradation, and both Ctk2 and Ctk3 are required for Ctk1 CTD kinase activation. The mammalian P-TEFb is mirrored by the combined complexes in yeast of the CTDK1 and the Bur1/2.
Pfam PF24653: Cyanophage outer membrane protein like beta barrel domain (domain)
This entry represents a family of small uncharacterised membrane bound beta barrel-like proteins found in cyanophage. The putative membrane beta barrel is incomplete composed of only 6 beta strands. However, the proteins form a confident homodimer (ipTM=0.78) composed of a flattened 12 stranded beta barrel. The proteins likely contain an N-terminal signal peptide that is cleaved during membrane insertion.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF14143: YrhC-like protein (family)
The YrhC-like protein family includes the B. subtilis YrhC protein [swissprot:O05395] which is functionally uncharacterised. YrhC is on the same operon as the MccA and MccB genes, which are involved in the conversion of methionine to cysteine. Expression of this operon is repressed in the presence of sulphate or cysteine. This family of proteins is found in bacteria. Proteins in this family are approximately 80 amino acids in length.
Pfam PF16008: Domain of unknown function (DUF4778) (family)
This family of proteins is functionally uncharacterised. This family of proteins is found in eukaryotes. Proteins in this family are typically between 321 and 791 amino acids in length. There is a single completely conserved residue P that may be functionally important.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF11385: Protein of unknown function (DUF3189) (family)
This family of proteins with unknown function appears to be restricted to Firmicutes
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.