SII-SWORD/CoKE huggingface dataset:
Pfam PF11369: Protein of unknown function (DUF3160) (family)
This family of proteins has no known function.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF21573: Formin C, N-terminal domain (domain)
This domain is found at the N-terminal end of Formin-C from Dictyostelium discoideum (ForC) and similar proteins predominantly found in amoebas. ForC is involved in the regulation of local actin cytoskeleton reorganisation. It contains a N-terminal putative GTPase-binding domain (GBD, this entry), an FH3, and an FH2 domain ([pfam:PF02181]). This domain adopts an ubiquitin-like alpha/beta-roll fold with an unusually long loop between the first and second beta- strands.
Wikipedia: Formins (formin homology proteins) are a group of proteins that are involved in the polymerization of actin and associate with the fast-growing end (barbed end) of actin filaments. Most formins are Rho-GTPase effector proteins. Formins regulate the actin and microtubule cytoskeleton 
 and are involved in various cellular functions such as cell polarity, cytokinesis, cell migration and SRF transcriptional activity. Formins are multidomain proteins that interact with diverse signalling molecules and cytoskeletal proteins, although some formins have been assigned functions within the nucleus.
Pfam PF20429: RNA-binding protein Tab2/Atab2, C-terminal domain (domain)
This is the C-terminal domain of Tab2 from plant and cyanobacteria. Tab2 was first identified in Chlamydomonas reinhardtii as a RNA binding protein required for translation of the chloroplast PsaB photosystem I subunit. Later, the Tab2 homologue from Arabidopsis (Atab2) was found involved in the signalling pathway of light-controlled synthesis of photosystem proteins during early plant development, presumably functioning as an activator of translation with targets at PSI and PSII. Directed mutagenesis experiments carried out in Chlamydomonas reinhardtii, Tab2 [swissprot:Q7X8Y6], indicated the importance of a highly conserved C-terminal tripeptide WLL for normal psaB translation.
Pfam PF00238: Ribosomal protein L14p/L23e (domain)
This entry represents the large ribosomal subunit protein uL14 (formerly known as L14) from all domains of life. In eubacteria, uL14 is known to bind directly to the 23S rRNA. It belongs to a family of ribosomal proteins, which have been grouped on the basis of sequence similarities. Based on amino-acid sequence homology, it is predicted that ribosomal protein L14 is a member of a recently identified family of structurally related RNA-binding proteins . L14 is a protein of 119 to 137 amino-acid residues.
Ribosomes are the particles that catalyse mRNA-directed protein synthesis in all organisms. The codons of the mRNA are exposed on the ribosome to allow tRNA binding. This leads to the incorporation of amino acids into the growing polypeptide chain in accordance with the genetic information. Incoming amino acid monomers enter the ribosomal A site in the form of aminoacyl-tRNAs complexed with elongation factor Tu (EF-Tu) and GTP. The growing polypeptide chain, situated in the P site as peptidyl-tRNA, is then transferred to aminoacyl-tRNA and the new peptidyl-tRNA, extended by one residue, is translocated to the P site with the aid the elongation factor G (EF-G) and GTP as the deacylated tRNA is released from the ribosome through one or more exit sites . About 2/3 of the mass of the ribosome consists of RNA and 1/3 of protein. The proteins are named in accordance with the subunit of the ribosome which they belong to the small (S1 to S31) and the large (L1 to L44). Usually they decorate the rRNA cores of the subunits.

Many ribosomal proteins, particularly those of the large subunit, are composed of a globular, surfaced-exposed domain with long finger-like projections that extend into the rRNA core to stabilise its structure. Most of the proteins interact with multiple RNA elements, often from different domains. In the large subunit, about 1/3 of the 23S rRNA nucleotides are at least in van der Waal's contact with protein, and L22 interacts with all six domains of the 23S rRNA. Proteins S4 and S7, which initiate assembly of the 16S rRNA, are located at junctions of five and four RNA helices, respectively. In this way proteins serve to organise and stabilise the rRNA tertiary structure. While the crucial activities of decoding and peptide transfer are RNA based, proteins play an active role in functions that may have evolved to streamline the process of protein synthesis. In addition to their function in the ribosome, many ribosomal proteins have some function 'outside' the ribosome .
Pfam PF12905: Endo-alpha-N-acetylgalactosaminidase (domain)
Virulence of pathogenic organisms such as the Gram-positive Streptococcus pneumoniae is largely determined by the ability to degrade host glycoproteins and to metabolise the resultant carbohydrates. This family is the enzymatic region, [ec:3.2.1.97], of the cell surface proteins that specifically cleave Gal-beta-1,3-GalNAc-alpha-Ser/Thr (T-antigen, galacto-N-biose), the core 1 type O-linked glycan common to mucin glycoproteins. This reaction is exemplified by the S. pneumoniae protein [swissprot:B2DRU5], where Asp764 is the catalytic nucleophile-base and Glu796 the catalytic proton donor.
Wikipedia: In molecular biology, glycoside hydrolase family 101 is a family of glycoside hydrolases.
Pfam PF05624: Lipolysis stimulated receptor (LSR) (domain)
The lipolysis-stimulated receptor (LSR) is a lipoprotein receptor primarily expressed in the liver and activated by free fatty acids.  It is thought to be involved in the clearance of triglyceride-rich lipoproteins, and has been shown in mice to be critical for liver and embryonic development.
Pfam PF19338: Neutrophin-3 N-terminus (family)
This family represents the N-terminal region of neutrophin-3 (NTF3) which contains two precursor homology regions located upstream of the mature NTF3 sequence. These regions play important and specific roles in the folding, processing and transport of neurotrophic factors.
Pfam PF08524: rRNA processing (domain)
This is a family of proteins that are involved in rRNA processing.  In a localisation study they were found to localise to the nucleus and nucleolus. The family also includes other metazoa members from plants to mammals where the protein has been named BR22 and is associated with TTF-1, thyroid transcription factor 1. In the lungs, the family binds TTF-1 to form a complex which influences the expression of the key lung surfactant protein-B (SP-B) and -C (SP-C), the small hydrophobic surfactant proteins that maintain surface tension in alveoli.
Pfam PF10936: Protein of unknown function DUF2617 (family)
This bacterial family of proteins has no known function.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF08692: Mitochondrial protein Pet20 (family)
Pet20 is a mitochondrial protein which is thought to play a role in the correct assembly/maintenance of mitochondrial components.
Pfam PF18093: tRNA methyltransferase 5 N-terminal domain (domain)
This is the N-terminal domain of tRNA methyltransferase 5 (Trm5) present in Methanocaldococcus jannaschii. Trm5 catalyzes the methyl transfer from S-adenosyl methionine (AdoMet) to N1 of G37. This domain, also known as the D1 domain, contacts the tertiary core (elbow) region of the tRNA L shape in a ternary complex of the enzyme with tRNA and AdoMet.
Pfam PF11884: Domain of unknown function (DUF3404) (family)
This domain is functionally uncharacterised. This domain is found in bacteria. This presumed domain is about 260 amino acids in length. This domain is found associated with [pfam:PF02518], [pfam:PF00512].
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF11791: Aconitate B N-terminal domain (repeat)
This family represents the N-terminal domain of Aconitase B.
Pfam PF13828: Domain of unknown function (DUF4190) (domain)
This integral membrane domain is functionally uncharacterised. One of the membrane helices contains two GXXG motifs that are usually associated with dimerisation.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF15758: Histidine-rich carboxyl terminus protein 1 (family)
The function of this family of proteins is not known.
Pfam PF10940: Leader peptide SpeFL (family)
SpeFL is a small protein (arrest peptide) encoded upstream of inducible ornithine carboxylase gene (speF) that controls expression of downstream genes (speF and patE) by nascent chain-translational arrest and transcriptional attenuation. Ornithine capture by a translating ribosome controls bacterial polyamine synthesis, inducing the expression of ornithine decarboxylase SpeF4, in a mechanism involving ribosome stalling and transcription antitermination
Pfam PF04844: Transcriptional repressor, ovate (family)
This is a family of transcriptional repressors. In plants, these proteins are important regulators of growth and development.
Pfam PF05932: Tir chaperone protein (CesT) family (domain)
This family consists of a number of bacterial sequences which are highly similar to the Tir chaperone protein in E. Coli. In many Gram-negative bacteria, a key indicator of pathogenic potential is the possession of a specialised type III secretion system, which is utilised to deliver virulence effector proteins directly into the host cell cytosol. Many of the proteins secreted from such systems require small cytosolic chaperones to maintain the secreted substrates in a secretion-competent state. CesT serves a chaperone function for the enteropathogenic Escherichia coli (EPEC) translocated intimin receptor (Tir) protein, which confers upon EPEC the ability to alter host cell morphology following intimate bacterial attachment. This family also contains several DspF and related sequences from several plant pathogenic bacteria. The "disease-specific" (dsp) region next to the hrp gene cluster of Erwinia amylovora is required for pathogenicity but not for elicitation of the hypersensitive reaction. DspF and AvrF are small (16 kDa and 14 kDa) and acidic with predicted amphipathic alpha helices in their C termini; they resemble chaperones for virulence factors secreted by type III secretion systems of animal pathogens.
Pfam PF13400: Putative Flp pilus-assembly TadE/G-like (domain)
This is an N-terminal domain on a family of putative Flp pilus-assembly proteins. The exact function is not known. The Flp-pilus biogenesis genes include the Tad genes, and some members of this family are putatively assigned as being TadG.
Pfam PF20128: Family of unknown function (DUF6518) (family)
This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 205 and 220 amino acids in length.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF02945: Recombination endonuclease VII (domain)
This family of proteins which includes Bacteriophage T4 endonuclease VII, Mycobacteriophage D29 gene 59, and other as yet uncharacterised proteins. The T4 endonuclease VII (Endo VII) recognises a broad spectrum of DNA substrates ranging from branched DNAs to single base mismatches. The structure of this enzyme has been resolved and it was found that the monomers form an elongated, intertwined molecular dimer that exibits extreme domain swapping. Two pairs of antiparallel helices which form a novel 'four-helix cross' motif are the major dimerisation elements .
Pfam PF12569: N-terminal acetyltransferase A, auxiliary subunit (repeat)
This entry represents N-terminal acetyltransferase A (NatA) auxiliary subunit (also known as NMDA receptor-regulated protein 1), which is a non-catalytic component of the NatA N-terminal acetyltransferase that catalyses acetylation of proteins beginning with Met-Ser, Met-Gly and Met-Ala. N-terminal acetylation plays a role in normal eukaryotic translation and processing, protecting against proteolytic degradation and protein turnover. NAT1 anchors ARD1 and NAT5 to the ribosome, and may present the N terminus of nascent polypeptides for acetylation.
Pfam PF00284: Lumenal portion of Cytochrome b559, alpha (gene psbE) subunit (family)
This family is the lumenal portion of cytochrome b559 alpha chain, matches to this family should be accompanied by a match to the [pfam:PF00283] family also. The Prosite pattern pattern matches the transmembrane region of the cytochrome b559 alpha and beta subunits.
Wikipedia: Cytochrome b559 is an important component of Photosystem II (PSII) is a multisubunit protein-pigment complex containing polypeptides both intrinsic and extrinsic to the photosynthetic membrane. Within the core of the complex, the chlorophyll and beta-carotene pigments are mainly bound to the antenna proteins CP43 (PsbC) and CP47 (PsbB), which pass the excitation energy on to chlorophylls in the reaction centre proteins D1 and D2 that bind all the redox-active cofactors involved in the energy conversion process. The PSII oxygen-evolving complex (OEC) provides electrons to re-reduce the PSII reaction center, and oxidizes 2 water molecules to recover its reduced initial state. It consists of OEE1 (PsbO), OEE2 (PsbP) and OEE3 (PsbQ). The remaining subunits in PSII are of low molecular weight, and are involved in PSII assembly, stabilisation, dimerization, and photoprotection.
Pfam PF21570: Arginine dihydrolase ArgZ-like, C-terminal, Rossmann fold (domain)
This domain is found at the C-terminal end of Arginine dihydrolase ArgZ from Synechocystis sp (also known as Sll1336 protein) and similar prokaryotic sequences. ArgZ is involved in an ornithine- ammonia cycle (OAC) in cyanobacteria, which confers substantial adaptability under environmental nitrogen fluctuations. This protein is organised into three domains: a N-terminal domain belonging to the guanidino group-modifying enzyme (GME) family, a middle oxoglutarate reductase/saccharopine dehydrogenase bifunctional enzyme ([pfam:PF04455]) and a C-terminal uncharacterized region that can be divided in two subdomains. This entry represents the most C-terminal region, which forms a large Rossmann fold domain. Its specific function is unknown.
Pfam PF24087: Domain of unknown function (DUF7372) (domain)
This entry represents a small family of uncharacterised phage proteins. Structure prediction shows the proteins form a compact globular domain composed of a four stranded beta sheet, with a strand order of 4-1-2-3 with an alpha helix between strands 3 and 4.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF20560: Motility protein A N-terminal (domain)
This entry represents the N-terminal domain of Motility protein A (MotA). MotA is a membrane protein that forms the stator element of the flagellar motor complex together with MotB with 5:2 stoichiometry, which couples ion flow across the cytoplasmic membrane to generate torque, and thus, it is required for rotation of the flagellar motor. This domain contains conserved torque-generating charged residues at the C-terminal and is adjacent [pfam:PF01618], which represents MotA TMH3 and TMH4.
Pfam PF09624: Protein of unknown function (DUF2393) (family)
The function of this protein is unknown. It is always found as part of a two-gene operon with IPR013416, a protein that appears to span the membrane seven times. It has so far been found in the bacteria Nostoc sp. PCC 7120, Agrobacterium tumefaciens, Rhizobium meliloti, and Gloeobacter violaceus.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF21686: LigD, primase-polymerase domain (domain)
This entry represents the primase-polymerase domain (Prim-Pol) of bacterial LigD proteins, such as LigD from Pseudomonas aeruginosa and Mycobacterium tuberculosis. LigD, together with Ku protein, is required for nonhomologous end-joining (NHEJ)-mediated repair of DNA double-strand breaks (DSB). This domain belongs to the archaeal/eukaryal primase (AEP) superfamily and mediates several nucleotidyl transferase activities, including DNA-dependent RNA primase, terminal transferase and DNA-dependent DNA/RNA gap-filling polymerase activities.
Pfam PF12126: PML-like, coiled-coil (coiled_coil)
This is the coiled-coil region of PML, also known as TRIM19. PML acts in association with PML-nuclear bodies (PML-NBs) in a wide range of important cellular processes, such as tumour, suppression, transcriptional regulation, apoptosis, senescence, DNA damage response, and viral defense mechanisms. PML is defined by the TRIM/RBCC motif which consists of an N-terminal RING zinc finger, two BBox type zinc fingers followed by a coiled-coil region. This coiled-coil region is thought to mediate interactions with cytomegalovirus IE1 protein and/or other partners. This entry also includes RNF207, which has a similar organisation.
Pfam PF02609: Exonuclease VII small subunit (family)
This family consist of exonuclease VII, small subunit [ec:3.1.11.6] This enzyme catalyses exonucleolytic cleavage in either 5'->3' or 3'->5'  direction to yield 5'-phosphomononucleotides.  This exonuclease VII enzyme is composed of one large subunit and 4 small ones.
Wikipedia: The enzyme exodeoxyribonuclease VII is a bacterial exonuclease enzyme. It is composed of two nonidentical subunits; one large subunit and 4 small ones. that catalyses exonucleolytic cleavage in either 5′- to 3′- or 3′- to 5′-direction to yield nucleoside 5′-phosphates. The large subunit also contains an N-terminal OB-fold domain that binds to nucleic acids.
Pfam PF10413: Amino terminal of the G-protein receptor rhodopsin (domain)
Rhodopsin is the archetypal G-protein-coupled receptor. Such receptors participate in virtually all physiological processes, as signalling molecules. They utilise heterotrimeric guanosine triphosphate (GTP)-binding proteins to transduce extracellular signals to intracellular events.  Rhodopsin is important because of the pivotal role it plays in visual signal transduction. Rhodopsin is a dimeric transmembrane protein and its intradiskal surface consists of this amino terminal domain and three loops connecting six of the seven transmembrane helices. The N-terminus is a compact domain of alpha-helical regions with breaks and bends at proline residues outside the membrane. The transmembrane part of rhodopsin is represented by 7tm_1 ([pfam:PF00001]). The N-terminal domain is extracellular is and is necessary for successful dimerisation and molecular stability.
Pfam PF18978: Family of unknown function (DUF5714) (domain)
This is a family of unknown function, mainly found in bacteria. It is distantly related to Pfam family [pfam:PF09719], which is a heme binding cytochrome. This domain is found associated with other domains such as the Radical SAM domain and a methyltransferase.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF18686: Family of unknown function (DUF5636) (domain)
This is a domain of unknown function mostly found in gammaproteobacteria.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF22473: PilJ, Pilin domain (domain)
This entry represents a N-terminal Pilin-like domain of PilJ from  Clostridium difficile.
Pfam PF11286: Protein of unknown function (DUF3087) (family)
This family of proteins with unknown function appears to be restricted to Gammaproteobacteria.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF21994: AGAO-like N2 domain (domain)
This entry represents the first N-terminal domain (N2) of a group of copper amine oxidases, including PAOX from Arthrobacter globiformis ([swissprot:P46881], also known as AGAO).
Pfam PF07515: Putative conjugal transfer nickase/helicase TraI C-term (domain)
This entry contains proteins some of which are from pathogenic strains of Gammaproteobacteria. Though the function of these proteins is unknown, they could be involved in pathogenesis. This domain is found at the C terminus of proteins that contain a N-terminal metal-dependent phosphohydrolase (HD) region and are considered to be helicases/relaxases .
Pfam PF13406: Transglycosylase SLT domain (domain)
This family is related to the SLT domain [pfam:PF01464].
Pfam PF15419: Leukemia NUP98 fusion partner 1 (family)
This family of proteins includes leukemia NUP98 fusion partner 1, the gene encoding this protein is involved in a chromosomal translocation with the NUP98 locus in a form of T-cell acute lymphoblastic leukemia.