SII-SWORD/CoKE huggingface dataset:
Pfam PF19430: TBC1 domain family member 23 C-terminal (domain)
TBC1 domain family member 23 (TBC1D23) belongs to a family of TBC domain-containing Rab-specific GTPase-activating proteins, which plays a role in endosome-to-Golgi trafficking. It acts as a bridging factor in which the TBC domain binds to Golgi adaptor proteins golgin-97 and golgin-245 and its C-terminal to FAM21 subunit of the WASH complex, which regulates multiple endosomal trafficking routes. TBC1D23 is important for normal brain development, especially in axonal and dendritic growth. This entry represents the C-terminal domain that contains residues for specific FAM21 binding and for the cargo of endosome-derived carriers. It adopts a fold similar to the Pleckstrin homology (PH) domain. Mutations in this protein, and particularly in this domain, are  linked with Pontocerebellar hypoplasia (PCH), suggesting that the TBC1D23 C-terminal domain is required for neuronal growth and brain development.
Pfam PF22968: E3 ubiquitin-protein ligase rififylin-like domain (domain)
This entry represents a domain found in human E3 ubiquitin -protein ligase rififylin (RNF34L) and similar eukaryotic proteins. RNF34L regulates several biological processes through the ubiquitin-mediated proteasomal degradation of various target proteins. This domain is predicted to adopt an helix-extended loop-helix (HeH) structure.
Pfam PF15558: Domain of unknown function (DUF4659) (family)
This family of proteins is found in eukaryotes. Proteins in this family are typically between 427 and 674 amino acids in length. There are two completely conserved residues (D and I) that may be functionally important.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF04596: Poxvirus protein F15 (family)
This entry represents Protein F15 from Vaccinia virus, also known as Protein OPG060, and similar sequences from poxvirus. The function of this protein is still unknown.
Pfam PF24546: TPPC8 fourth Ig-like domain (domain)
This entry represents the fourth Ig-like domain found in the middle region of TPPC8 from human and related sequences from vertebrates. TPPC8 plays a role in endoplasmic reticulum to Golgi apparatus trafficking at a very early stage. Together with TBC1D14, it maintains the cycling pool of ATG9 required for initiation of autophagy. It is one of the TRAPPIII complex specific subunits.
Pfam PF05929: Phage capsid scaffolding protein (GPO) serine peptidase (family)
This family consists of several bacteriophage capsid scaffolding proteins (GPO) and some related bacterial sequences. GPO is thought to function in both the assembly of proheads and the cleavage of GPN. The family is found to function as a serine peptidase, with a conserved Asp, His and Ser catalytic triad, as in subtilisin, and as represented in MEROPS:S73. The family includes SwissProt:P25478 from Enterobacteria phage P2 which cleaves itself and then becomes the scaffold protein upon which the bacteriophage prohead is built - a mechanism quite common amongst phages.
Pfam PF03617: IBV 3A protein (family)
The gene product of gene 3 from Avian infectious bronchitis virus. Currently, the function of this protein remains unknown.
Pfam PF25062: Tetratricopeptide repeat protein 21 N-terminal ARM repeat (repeat)
This entry represents the N-terminal segment of ARM repeats of Tetratricopeptide repeat protein 21 (TT21) from human and its homologues. TT21 is an intraflagellar transport (IFT)-associated protein required for spermatogenesis. It is involved in sperm flagellar formation and intraflagellar transport.
Pfam PF25123: SUPPRESSOR-OF-WHITE-APRICOT-like, C-terminal (domain)
This domain is found at the C-terminal end of SUPPRESSOR-OF -WHITE-APRICOT from Arabidopsis thaliana (SWAP1), a member of the SWAP1-SFPS-RRC1 splicing factor complex that modulates photomorphogenesis by regulating the gene expression and pre-messenger RNA alternative splicing of a large number of genes, including those involved in plant responses to light signalling.
Pfam PF24021: Phage ACT-like domain (domain)
This entry represents an uncharacterised phage protein family. It contains an N-terminal domain that looks like an ACT domain.
Pfam PF03908: Sec20 (domain)
Sec20 is a membrane glycoprotein and a SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptor) involved in retrograde transport from the Golgi to the endoplasmic  reticulum (ER). It is also required for N- and O-glycosylation in  the Golgi.
Pfam PF21812: Domain of unknown function (DUF6881) (domain)
This entry represents a small bacterial protein of unknown function. Its predicted structure shows a 6 stranded beta sheet with a C-terminal helix packed on one side. In a few proteins this domain is associated with [pfam:PF15595] a presumed immunity protein, which could suggest this domain may have a toxin function or be involved in a toxin/antitoxin system or in phage defence.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF14636: Folliculin-interacting protein N-terminus (family)
This is the N-terminus of folliculin-interacting proteins.
Pfam PF06657: Centrosome microtubule-binding domain of Cep57 (domain)
This C-terminal region of Cep57 binds, nucleates and bundles microtubules. The N-terminal part, family Cep57_CLD, [pfam:PF14073], is the centrosome localisation domain Cep57.
Pfam PF18642: Immunomodulating metalloprotease helical domain (domain)
IMPa is an immunomodulator metalloprotease that belongs to the peptidase M60 family [pfam:PF13402]. This entry represents the helical domain found at the N-terminal of the Ig domain.
Pfam PF07581: The GLUG motif (family)
This family is found in the IgA1 (M26) peptidases, which attached to the cell wall peptidoglycan by an amide bond (). IgA1 protease selectively cleaves human IgA1 and  is likely to be a pathogenicity factor in some pathogens (). This family is also found in various other contexts, including with [pfam:PF05860]. It is named GLUG after the mostly conserved G-L-any-G motif.
Pfam PF19400: Family of unknown function (DUF5975) (family)
This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0000486) is described by MIBiG as an example of the following biosynthetic class, RiPP (ribosomally synthesised and post-translationally modified peptide).
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF16577: UBA domain (domain)
UBA_2 is a domain found on eukaryotic ubiquitin-interacting proteins. Sequestosome 1/p62 has recently been shown to interact with polyubiquitinated proteins through its UBA domain. This domain selectively binds K63-polyubiquitinated proteins.
Pfam PF17821: Family of unknown function (DUF5583) (family)
This is a family of unknown function found in chordata.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF15471: Transmembrane protein family 171 (family)
This family of proteins is found in eukaryotes. TMEM171 is also known as parturition-related protein 2. Proteins in this family are typically between 242 and 326 amino acids in length.
Pfam PF12192: Fungal calcium binding protein (domain)
This domain is found in eukaryotes, and is approximately 60 amino acids in length. There is a single completely conserved residue C that may be functionally important. This is a calcium binding domain from the fungal protein CBP (calcium binding protein). This protein is a virulence factor with unknown virulence mechanisms. CBP complexes as a highly intertwined homodimer. Each monomer is comprised of four alpha helices which adopt the saposin fold, characteristic of a protein family that binds to membranes and lipids.
Pfam PF23799: Domain of unknown function (DUF7175) (domain)
This entry represents an uncharacterized protein family found in various phages infecting Gram-negative bacterial hosts, including Salmonella, Shigella, Erwinia, Aeromonas, Vibrio and Klebsiella phages.  The family typically contains proteins between 80-120 amino acids in length. The function of this protein family is currently unknown.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF18858: Large polyvalent protein associated domain 39 (domain)
This is a predicted enzymatic alpha-helical domain that is associated with polyvalent proteins of phages and prophages.
Pfam PF15826: Bcl-2-binding component 3, p53 upregulated modulator of apoptosis (family)
PUMA (p53 upregulated modulator of apoptosis) is a family of eukaryotic proteins that are a target for activation by p53. The proteins contain BH3 domains and are induced in cells after p53 activation. They bind to Bcl-2, localise to the mitochondria to induce cytochrome c release, and activate the rapid induction of apoptosis.
Pfam PF08188: Spermatozal protamine family (family)
This family consists of the spermatozal protamines.  Spermatozal protamines play an important role in remodelling of the sperm chromatin during mammalian spermiogenesis. Nuclear elongation and chromatin condensation are concomitant with modifications in the basic protein complement associated with DNA.  Somatic histones are initially replaced by testis -specific histone variants, then by transitional proteins, and ultimately by protamines.
Pfam PF07918: CAP160 repeat (repeat)
This region featured in this family is repeated in spinach cold acclimation protein CAP160 ([swissprot:O50054]) CAP160 is induced during periods of drought stress; its precise function is unknown but it has been implicated in the stabilisation of membranes, cytoskeletal elements, and ribosomes. By acting as a compatible solute, it may reduce the toxic effects of cellular solutes that accumulate at high concentration during dehydration; it may also function as an enzyme that produces such a solute. Other members of this family are also induced by water stress, abscisic acid, and/or low temperature, such as desiccation-responsive protein 29B ([swissprot:Q04980]) and CDet11-24 protein ([swissprot:O23764]).
Pfam PF13292: 1-deoxy-D-xylulose-5-phosphate synthase (family)
This family contains 1-deoxyxylulose-5-phosphate synthase (DXP synthase), an enzyme which catalyses the thiamine pyrophosphoate-dependent acyloin condensation reaction between carbon atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate, to yield 1-deoxy-D- xylulose-5-phosphate, a precursor in the biosynthetic pathway to isoprenoids, thiamine (vitamin B1), and pyridoxol (vitamin B6).
Pfam PF19654: Family of unknown function (DUF6157) (family)
This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 140 amino acids in length.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF15420: Alpha/beta-hydrolase family N-terminus (family)
This is the N-terminal transmembrane domain of a family of alpha/beta hydrolases which may function as lipases. The C-terminal domain ([pfam:PF10081]) is the catalytic domain.
Pfam PF08232: Striatin family (family)
Striatin is an intracellular protein which has a caveolin-binding motif, a coiled-coil structure, a calmodulin-binding site, and a WD ([pfam:PF00400]) repeat domain. It acts as a scaffold protein and is involved in signalling pathways.
Pfam PF18247: Flax-rust effector AvrM N-terminal domain (domain)
This is the N-terminal domain found in AvrM present in Melampsora lini. AvrM is a secreted effector protein that can internalize into plant cells in the absence of pathogens, binds to phosphoinositides and results in effector-triggered immunity. This domain is related to the WY domain core in oomycete effectors.
Pfam PF12584: Trafficking protein particle complex subunit 10, TRAPPC10 (family)
This domain forms part of the TRAPP complex for mediating vesicle docking and fusion in the Golgi apparatus. The fungal version is referred to as Trs130, and an alternative vertebrate alias is TMEM1.
Pfam PF13598: Domain of unknown function (DUF4139) (family)
This family is usually found at the C-terminus of proteins.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF22941: Transcriptional adapter 2-alpha-like domain (domain)
This domain is found in human Transcriptional adapter 2-alpha (TADA2A) and similar eukaryotic proteins. TADA2A is a component of the ATAC complex that plays a role in chromatin remodelling. This domain is predicted to adopt an alpha-beta structure.
Pfam PF22514: EXPB1-like domain 1 (domain)
Expansins are small extracellular proteins that promote turgor-driven extension of plant cell walls. EXPB1 is a member of the beta-expansin subfamily induces extension and stress relaxation of grass cell walls. This entry represents EXPB1 domain 1 and domains found in similar proteins..
Pfam PF22989: Domain of unknown function (DUF7030) (domain)
This domain of unknown function is found in Lysine-specific demethylase 3B (KDM3B, also known as JmjC domain-containing histone demethylation protein 2B or JHDM2B) and related proteins. KDM3B is a histone demethylase that specifically demethylates lysine at position 9 of histone H3. This enzyme plays a central role in histone code. This domain is predicted to adopt an open beta-barrel with an SH3-like topology.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF01323: DSBA-like thioredoxin domain (domain)
This family contains a diverse set of proteins with a thioredoxin-like structure [pfam:PF00085]. This family also includes 2-hydroxychromene-2-carboxylate (HCCA) isomerase enzymes catalyse one step in prokaryotic polyaromatic hydrocarbon (PAH) catabolic pathways.  This family also contains members with functions other than HCCA isomerisation, such as Kappa family GSTs (e.g. [swissprot:P24473]), whose similarity to HCCA isomerases was not previously recognised.  The sequence [swissprot:O07298] has been annotated as a dioxygenase but is almost certainly an HCCA isomerase enzyme. Similarly, the sequence [swissprot:Q9ZI67] has been annotated as a dehydrogenase, but is most probably also an HCCA isomerase enzyme. In addition, the Rhizobium leguminosarum [swissprot:Q52782] protein has been annotated as a putative glycerol-3-phosphate transfer protein, but is also most likely to be an HCCA isomerase enzyme (see).
Wikipedia: DsbA is a bacterial thiol disulfide oxidoreductase (TDOR). DsbA is a key component of the Dsb family of enzymes. DsbA catalyzes intrachain disulfide bond formation as peptides emerge into the cell's periplasm.
Pfam PF17335: Ino80 complex subunit 5 (family)
The INO80 chromatin remodeling complex is known to be related to DNA repair in yeast, mammals, and plants. In yeast, the INO80 complex is recruited to the DSBs (DNA double-strand breaks) through the direct interaction of its Nhp10 (non-histone protein 10) or Arp4 (Actin-Related Protein) subunits with phosphorylated histone H2A. However, the ortholog of yeast Nhp10 does not exist in mammals. The Nhp10 module consists of Nhp10, Ies1, Ies3, and Ies5. These yeast-specific subunits cross-link to the N terminus of Ino80 and form a stable complex in-vitro, which helps high-affinity targeting of INO80 to nucleosome-binding.
Pfam PF10217: Uncharacterized conserved protein (DUF2039) (family)
This entry is a region of approximately 100 residues containing three pairs of cysteine residues. The region is conserved from plants to humans but its function is unknown.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF23618: Bacteriophage T4 gp9/10-like protein, C-terminal (domain)
This entry represents the C-terminal domain of Baseplate protein gp9 from Bacteriophage T4, a component of the viral baseplate. Gp9 connects the long tail fibres of the virus to the baseplate and triggers tail contraction after viral attachment to a host cell. The protein is active as a trimer, with each monomer being composed of three domains. The C-terminal domain is thought to be essential for trimerisation and is organised into an eight- stranded antiparallel beta-barrel, which was found to resemble the 'jelly roll' fold found in many viral capsid proteins. Together with gp11, gp10 initiates the assembly of wedges that then go on to associate with a hub to form the viral baseplate.
Pfam PF06333: Mediator complex subunit 13 C-terminal domain (domain)
Mediator is a large complex of up to 33 proteins that is conserved from plants through fungi to humans - the number and representation of individual subunits varying with species. It is arranged into four different sections, a core, a head, a tail and a kinase-activity part, and the number of subunits within each of these is what varies with species. Overall, Mediator regulates the transcriptional activity of RNA polymerase II but it would appear that each of the four different sections has a slightly different function. Med13 is part of the ancillary kinase module, together with Med12, CDK8 and CycC, which in yeast is implicated in transcriptional repression, though most of this activity is likely attributable to the CDK8 kinase. The large Med12 and Med13 proteins are required for specific developmental processes in Drosophila, zebrafish, and Caenorhabditis elegans but their biochemical functions are not understood. This domain is also identified as an RNaseH domain of the medPIWI PIWI/Argonaute module. medPIWI is the core domain found in the Med13 protein. The medPIWI module in Med13 is predicted to bind double-stranded nucleic acids, triggering the experimentally-observed conformational switch in the CDK8 subcomplex which regulates the Mediator complex.
Wikipedia: Mediator complex subunit 13 is a protein that in humans is encoded by the MED13 gene.
Pfam PF17229: Serine/threonine-protein kinase SMG1 N-terminal (disordered)
This entry represents the N-terminal disordered region of SMG1, which is a member of the phosphoinositide 3 kinase-like kinase (PIKK) family. SMG1 associates with components of the mRNA surveillance complex and is involved in the regulation of nonsense-mediated mRNA decay. It also plays an important role in genotoxic stress responses to DNA damage.
Pfam PF10312: Conserved mid region of cactin (family)
This is the conserved middle region of a family of proteins referred to as cactins. The region contains two of three predicted coiled-coil domains. Most members of this family have a CactinC_cactus [pfam:PF09732] domain at the C-terminal end. Upstream of Mid_cactin in Drosophila members are a serine-rich region, some non-typical RD motifs and three predicted bipartite nuclear localisation signals, none of which are well-conserved. Cactin associates with IkappaB-cactus as one of the intracellular members of the Rel (NF-kappaB) pathway which is conserved in invertebrates and vertebrates. In mammals, this pathway controls the activities of the immune and inflammatory response genes as well as viral genes, and is critical for cell growth and survival. In Drosophila, the Rel pathway functions in the innate cellular and humoral immune response, in muscle development, and in the establishment of dorsal-ventral polarity in the early embryo.
Pfam PF11833: Protein CHAPERONE-LIKE PROTEIN OF POR1-like (family)
This entry includes proteins from bacteria and eukaryotes. The plant  member, CHAPERONE-LIKE PROTEIN OF POR1 (CPP1),  is an essential protein for chloroplast development, plays a role in the regulation of POR (light-dependent protochlorophyllide oxidoreductase) stability and function.
Pfam PF19103: Family of unknown function (DUF5790) (family)
This is a family of proteins of unknown function found predominantly in Halobacteria.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF09072: Translation machinery associated TMA7 (family)
TMA7 plays a role in protein translation. Deletions of the TMA7 gene results in altered protein synthesis rates.
Pfam PF07901: Protein of unknown function (DUF1672) (family)
This family is composed of hypothetical bacterial proteins of unknown function.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.