SII-SWORD/CoKE huggingface dataset:
Pfam PF16057: Domain of unknown function (DUF4800) (family)
This presumed domain is functionally uncharacterised. This domain family is found in eukaryotes, and is approximately 310 amino acids in length. The family is found in association with [pfam:PF02138], [pfam:PF00400]. There is a conserved RDN sequence motif.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF07456: Heptaprenyl diphosphate synthase component I (family)
This family contains component I of bacterial heptaprenyl diphosphate synthase ([ec:2.5.1.30]) (approximately 170 residues long). This is one of the two dissociable subunits that form the enzyme, both of which are required for the catalysis of the biosynthesis of the side chain of menaquinone-7.
Pfam PF09526: Probable metal-binding protein (DUF2387) (family)
Members of this family are small proteins, about 70 residues in length, with a basic triplet near the N-terminus and a probable metal-binding motif CPXCX(18)CXXC. Members are found in various proteobacteria.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF19025: Family of unknown function (DUF5751) (domain)
The function of this archaeal family is unknown.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF24117: Family of unknown function (DUF7391) (family)
This entry represents a small family of uncharacterised phage proteins.  Many of them are annotated as phage tail assembly chaperones, but there does not appear to be any evidence to support this annotation.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF16540: Arf6-interacting domain of mitotic kinesin-like protein 1 (domain)
This family is a C-terminal region of mitotic kinesin-like proteins that is necessary for the interaction with the small GTPase Arf6. MKLP1 is a Flemming body-localising protein essential for cytokinesis, so its interaction with Arf6 shows how Arf6 is involved in cytokinesis. The Arf6-MKLP1 complex plays a crucial role in cytokinesis by connecting the microtubule bundle and membranes at the cleavage plane.
Pfam PF12232: Myogenic determination factor 5 (family)
This domain family is found in eukaryotes, and is approximately 70 amino acids in length. The family is found in association with [pfam:PF00010], [pfam:PF01586]. There is a conserved CSD sequence motif. Myf5 is responsible for directing cells to the skeletal myocyte lineage during development. Myf5 is likely to act in a similar way to the other MRF4 proteins such as MyoD which perform the same function. These are histone acetyltransferases and histone deacetylases which activate and repress genes involved in the myocyte lineage.
Wikipedia: In molecular biology, the myogenic determination factor 5 proteins are a family of proteins found in eukaryotes. This family includes the Myf5 protein, which is responsible for directing cells to the skeletal myocyte lineage during development. Myf5 is likely to act in a similar way to the other MRF4 proteins such as MyoD which perform the same function. These are histone acetyltransferases and histone deacetylases which activate and repress genes involved in the myocyte lineage.
Pfam PF18927: Glycosyl-4,4'-diaponeurosporenoate acyltransferase (domain)
This family of proteins is found in certain bacterial lineages. In staphylococcus this protein is known to be Glycosyl-4,4'-diaponeurosporenoate acyltransferase an enzyme involved in the final step of synthesis of staphyloxanthin, an orange pigment found in most S. aureus strains.  Proteins in this family are typically between 157 and 184 amino acids in length. Members of the family contain and EXXH motif that may be functionally important.
Pfam PF09829: Uncharacterized protein conserved in bacteria (DUF2057) (family)
This domain, found in various prokaryotic proteins, has no known function.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF04325: Protein of unknown function (DUF465) (family)
Family members are found in small bacterial proteins, and also in the heavy chains of fungal proteins that contain the domain kinesin, in which this region is located C-terminal of the motor domain ([pfam:PF00225]). It adopts a coiled-coil-like conformation.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF07559: Flagellar basal body protein FlaE D2 domain (domain)
This entry consists of several bacterial FlaE flagellar proteins. These proteins are part of the flagellar basal body rod complex.  FlgE comprises two domains, D1 and D2, this entry represents D2, a flattened, eight-strand beta-barrel with significant irregularity and extra loops.
Pfam PF20709: Family of unknown function (DUF6823) (family)
This family of proteins is functionally uncharacterised. This protein family is found in eukaryotes. There are highly conserved motifs: QQE and RFDLR.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF21847: Domain of unknown function (DUF6906) (domain)
This entry represents a small domain found in a range of phage and bacterial proteins. Structurally it is composed of a three stranded beta meander packed against an alpha helix. The function of these proteins is unknown.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF13341: RAG2 PHD domain (domain)
This domain is found at the C-terminus of the RAG2 protein. The structure of this domain has been shown bound to histone H3 trimethylated at lysine 4 (H3K4me3).
Pfam PF22446: Head N-terminal domain (domain)
This entry represents a compact jelly-roll beta-sandwich domain (head domain) of the polysaccharide receptor-binding protein from  Lactococcus phage 1358.
Pfam PF10232: Mediator of RNA polymerase II transcription complex subunit 8 (family)
Arc32, or Med8, is one of the subunits of the Mediator complex of RNA polymerase II. The region conserved contains two alpha helices putatively necessary for binding to other subunits within the core of the Mediator complex. The N-terminus of Med8 binds to the essential core Head part of Mediator and the C-terminus hinges to Med18 on the non-essential part of the Head that also includes Med20.
Wikipedia: Mediator of RNA polymerase II transcription subunit 8 is an enzyme that in humans is encoded by the MED8 gene.
Pfam PF21137: Protein arginine N-methyltransferase 3, C2H2 zinc finger domain (domain)
This is the N-terminal helical domain of protein arginine N-methyltransferase 3 (ANM3/PRMT3) which has a C2H2 zinc finger. ANM3 catalyses both the monomethylation and asymmetric dimethylation of the guanidino nitrogens of arginine residues in target proteins and may regulate retinoic acid synthesis and signaling by inhibiting ALDH1A1 retinal dehydrogenase activity. PRMT3 orthologue from fission yeast, is a ribosomal protein that methylates guanidino nitrogens of arginyl residues in ribosomal protein rps2 and may regulate ribosome biosynthesis. This ZnF is required for its optimal enzymatic activity and contributes to substrate specificity.
Pfam PF11002: RFPL defining motif (RDM) (domain)
The RDM domain is found on RFPL (Ret finger protein like) proteins.  In humans, RFPL transcripts can be detected at the onset of neurogenesis in differentiating human embryonic stem cells, and in the developing human neocortex.  The RDM domain is thought to have emerged from a neofunctionalisation event.  It is found N terminal to the SPRY domain ([pfam:PF00622]).
Pfam PF05840: Bacteriophage replication gene A protein (GPA) (family)
This family consists of a group of bacteriophage replication gene A protein (GPA) like sequences from both viruses and bacteria. The members of this family are likely to be endonucleases.
Pfam PF05954: Phage tail baseplate hub (GPD) (family)
This family includes a number of phage late expression gene D proteins and related bacterial sequences. This family also includes Bacteriophage Mu P proteins and related sequences. This protein forms the phage central baseplate hub.
Pfam PF21241: DNA helicase UvsW, N-terminal (domain)
This is the small N-terminal alpha+beta domain of the DNA helicase UvsW from bacteriophage T4, which consists of five beta-strands and two alpha-helices. This domain is structurally homologous to the DNA-binding domain of the T4 transcription factor MotA, thus, it likely binds the nucleic acid substrate.
Pfam PF09451: Autophagy-related protein 27 (family)
Autophagy is a degradative transport pathway that delivers cytosolic proteins to the lysosome (vacuole)  and is induced by starvation . Cytosolic proteins appear inside the vacuole enclosed in autophagic vesicles. Autophagy significantly differs from other transport pathways by using double membrane layered transport intermediates, called autophagosomes . The breakdown of vesicular transport intermediates is a unique feature of autophagy . Autophagy can also function in the elimination of invading bacteria and antigens .

There are more than 25 AuTophaGy-related (ATG) genes that are essential for autophagy, although it is still not known how the autophagosome is made. Atg9 is a potential membrane carrier to deliver lipids that are used to form the vesicle. Atg27 is another transmembrane protein, and is a cycling protein .

It acts as an effector of VPS34 phosphatidylinositol 3-phosphate kinase signalling and regulates the cytoplasm to vacuole transport (Cvt) vesicle formation. It is also required for autophagy-dependent cycling of ATG9.
Pfam PF06346: Formin Homology Region 1 (repeat)
This region is found in some of the Diaphanous related formins (Drfs) (). It consists of low complexity repeats of around 12 residues.
Wikipedia: Formins (formin homology proteins) are a group of proteins that are involved in the polymerization of actin and associate with the fast-growing end (barbed end) of actin filaments. Most formins are Rho-GTPase effector proteins. Formins regulate the actin and microtubule cytoskeleton 
 and are involved in various cellular functions such as cell polarity, cytokinesis, cell migration and SRF transcriptional activity. Formins are multidomain proteins that interact with diverse signalling molecules and cytoskeletal proteins, although some formins have been assigned functions within the nucleus.
Pfam PF07451: Stage V sporulation protein AD (SpoVAD) (domain)
This family contains the bacterial stage V sporulation protein AD (SpoVAD), which is approximately 340 residues long. This is one of six proteins encoded by the spoVA operon, which is transcribed exclusively in the forespore at about the time of dipicolinic acid (DPA) synthesis in the mother cell. The functions of the proteins encoded by the spoVA operon are unknown, but it has been suggested they are involved in DPA transport during sporulation.
Pfam PF20382: Family of unknown function (DUF6677) (family)
This family of integral membrane proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 135 and 210 amino acids in length.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF02037: SAP domain (domain)
The SAP (after SAF-A/B, Acinus and PIAS) motif is a putative DNA/RNA binding domain found in diverse nuclear and cytoplasmic proteins.
Pfam PF11214: Mediator complex subunit 2 (family)
This family of mediator complex subunit 2 proteins is conserved in fungi. Cyclin-dependent kinase CDK8 or Srb10 interacts with and phosphorylates Med2. Post-translational modifications of Mediator subunits are important for regulation of gene expression.
Wikipedia: Mediator is a multiprotein complex that functions as a transcriptional coactivator in all eukaryotes. It was discovered in 1990 in the lab of Roger D. Kornberg, recipient of the 2006 Nobel Prize in Chemistry. Mediator complexes interact with transcription factors and RNA polymerase II. The main function of mediator complexes is to transmit signals from the transcription factors to the polymerase.
Pfam PF15592: Immunity protein 41 (family)
A predicted immunity protein with an alpha+beta fold and a conserved SF motif and tryptophan residue. Proteins containing this domain are present in bacterial polymorphic toxin systems as an immediate gene neighbour of the toxin gene, usually containing a domain of the Ntox21, Ntox29 or Tox-ART-RSE-like ADP-ribosyltransferase families.
Pfam PF09447: Cnl2/NKP2 family protein (family)
This family includes the Cnl2 kinetochore protein.
Pfam PF16262: Domain of unknown function (DUF4916) (domain)
This domain family consists of uncharacterized proteins around 175 residues in length and is mainly found in various Streptomyces species. The function of this family is unknown. This family is related to the NUDIX hydrolases.
Pfam PF06188: HrpE/YscL/FliH and V-type ATPase subunit E (family)
This is a prokaryotic family that contains proteins of the FliH and HrpE/YscL family.       These proteins are involved in type III secretion, which is the process that drives flagellar biosynthesis and mediates bacterial-eukaryotic interactions.  This family also V-type ATPase subunit E.     This subunit appears to form a tight interaction with subunit G in the F0 complex. Subunits E and G may act together as stators to prevent certain subunits from rotating with the central rotary element.  [pfam:PF01991] also contains V-type ATPase subunit E proteins.
Pfam PF09250: Bifunctional DNA primase/polymerase, N-terminal (domain)
Members of this family adopt a structure consisting of a core of antiparallel beta sheets. They are found in various bacterial hypothetical proteins, and have been shown to harbour both primase and polymerase activities.
Pfam PF17339: PH domain (domain)
This entry contains a PH domain.
Wikipedia: Pleckstrin homology domain or (PHIP) is a protein domain of approximately 120 amino acids that occurs in a wide range of proteins involved in intracellular signaling or as constituents of the cytoskeleton.
Pfam PF08518: Spa2 homology domain (SHD) of GIT (family)
GIT proteins are signaling integrators with GTPase-activating function which may be involved in the organisation of the cytoskeletal matrix assembled at active zones (CAZ).  The function of the CAZ might be to define sites of neurotransmitter release.  Mutations in the Spa2 homology domain (SHD) domain of GIT1 described here interfere with the association of GIT1 with Piccolo, beta-PIX, and focal adhesion kinase.
Pfam PF23128: YbjQ-like domain (domain)
This is a domain found in a group of eukaryotic proteins. This domain is predicted to adopt a YbjQ-like fold.
Pfam PF10506: Harmonin-binding protein USHBP1, PDZ-binding domain (domain)
The protein has a high homology to the tumour suppressor MCC (mutated in colon cancer; or MCC1 hereafter) and was named MCC2. MCC2 protein binds the first PDZ domain of AIE-75 with its C-terminal amino acids -DTFL. A possible role of MCC2 as a tumor suppressor has been put forward. The carboxyl terminus of the predicted protein was DTFL which matched the consensus motif X-S/T-X-phi (phi: hydrophobic amino acid residue) for binding to the PDZ domain of AIE-75.
Pfam PF15398: Domain of unknown function (DUF4619) (family)
This family of proteins is found in eukaryotes. Proteins in this family are typically between 128 and 299 amino acids in length.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF20107: Family of unknown function (DUF6497) (family)
This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 121 and 153 amino acids in length.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF22521: Carbamoyltransferase, Kae1-like Domain, second subdomain (domain)
This domain is found at the C-terminal end of Carbamoyltransferase from Caldanaerobacter subterraneus (HypF, [swissprot:Q8RDB0]) and similar prokaryotic sequences. HypF is involved in the biosynthesis of the nitrile group as a precursor of the cyano groups of hydrogenases. HypF consists of four domains: the acylphosphatase domain ([pfam:PF00708]), the Zn finger-like domain ([pfam:PF07503]), the YrdC-like domain ([pfam:PF01300]) and the Kae1 (kinase-associated endopeptidase 1)-like domain, which is composed of two alpha-beta subdomains ([pfam:PF17788] and this entry).
Pfam PF07755: Domain of unknown function (DUF1611_C) P-loop domain (domain)
This region is found in a number of hypothetical bacterial and archaeal proteins. According to structure it has a P-loop structure.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF18928: Family of unknown function (DUF5677) (family)
This family of proteins is found in bacteria, archaea, eukaryotes and viruses. Proteins in this family are typically between 250 and 347 amino acids in length. These proteins contain a conserved RXXXE motif an invariant Histidine that may be functionally important.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF00786: P21-Rho-binding domain (domain)
Small domains that bind Cdc42p- and/or Rho-like small GTPases. Also known as the Cdc42/Rac interactive binding (CRIB).
Pfam PF23397: Domain of unknown function (DUF7104) (repeat)
This entry includes uncharacterised fungal sequences which consist of repeats that may adopt an alpha-solenoid structure related to ankirin repeats. The overall arrangement of these repeats may have a horseshoe conformation similar to that in leucine-rich repeats.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF06823: Protein of unknown function (DUF1236) (family)
This family contains a number of hypothetical bacterial proteins of unknown function. Some family members contain more than one copy of the region represented by this family.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF21631: A9CJY8-like, N-terminal domain (domain)
This domain is found at the N-terminal end of a group of prokaryotic uncharacterised proteins that contain an ACT domain ([pfam:PF13840]) in the C-terminal region, including [swissprot:A9CJY8] from Agrobacterium fabrum. This domain folds into several beta-strands.
Pfam PF10490: Rb-binding domain of kinetochore protein Cenp-F/LEK1 (domain)
Cenp-F, a centromeric kinetochore, microtubule-binding protein consisting of two 1,600-amino acid-long coils, is essential for the full functioning of the mitotic checkpoint pathway. This domain is at the very C-terminus of the C-terminal coiled-coil, and is one of the key Rb-binding domains.