SII-SWORD/CoKE huggingface dataset:
Pfam PF01158: Ribosomal protein L36e (family)
A number of eukaryotic ribosomal proteins can be grouped on the basis of sequence similarities. The eL36 (also known as L36e) ribosomal family consists of mammalian , Caenorhabditis elegans and Drosophila L36, Candida albicans L39, and yeast YL39 ribosomal proteins .
Ribosomes are the particles that catalyse mRNA-directed protein synthesis in all organisms. The codons of the mRNA are exposed on the ribosome to allow tRNA binding. This leads to the incorporation of amino acids into the growing polypeptide chain in accordance with the genetic information. Incoming amino acid monomers enter the ribosomal A site in the form of aminoacyl-tRNAs complexed with elongation factor Tu (EF-Tu) and GTP. The growing polypeptide chain, situated in the P site as peptidyl-tRNA, is then transferred to aminoacyl-tRNA and the new peptidyl-tRNA, extended by one residue, is translocated to the P site with the aid the elongation factor G (EF-G) and GTP as the deacylated tRNA is released from the ribosome through one or more exit sites . About 2/3 of the mass of the ribosome consists of RNA and 1/3 of protein. The proteins are named in accordance with the subunit of the ribosome which they belong to the small (S1 to S31) and the large (L1 to L44). Usually they decorate the rRNA cores of the subunits.

Many ribosomal proteins, particularly those of the large subunit, are composed of a globular, surfaced-exposed domain with long finger-like projections that extend into the rRNA core to stabilise its structure. Most of the proteins interact with multiple RNA elements, often from different domains. In the large subunit, about 1/3 of the 23S rRNA nucleotides are at least in van der Waal's contact with protein, and L22 interacts with all six domains of the 23S rRNA. Proteins S4 and S7, which initiate assembly of the 16S rRNA, are located at junctions of five and four RNA helices, respectively. In this way proteins serve to organise and stabilise the rRNA tertiary structure. While the crucial activities of decoding and peptide transfer are RNA based, proteins play an active role in functions that may have evolved to streamline the process of protein synthesis. In addition to their function in the ribosome, many ribosomal proteins have some function 'outside' the ribosome .
Pfam PF00734: Fungal cellulose binding domain (domain)
The microbial degradation of cellulose and xylans requires several types of enzymes such as endoglucanases (3.2.1.4), cellobiohydrolases (3.2.1.91) (exoglucanases), or xylanases (3.2.1.8) . Structurally, cellulases and xylanases generally consist of a catalytic domain joined to a cellulose-binding domain (CBD) by a short linker sequence rich in proline and/or hydroxy-amino acids. The CBD of a number of fungal cellulases has been shown to consist of 36 amino acid residues, and it is found either at the N-terminal or at the C-terminal extremity of the enzymes. As it is shown in the following schematic representation, there are four conserved cysteines in this type of CBD domain, all involved in disulphide bonds.

                         +----------------+
                         |          +-----|---------+
                         |          |     |         |
                  xxxxxxxCxxxxxxxxxxCxxxxxCxxxxxxxxxCx
Wikipedia: In molecular biology, a carbohydrate-binding module (CBM) is a protein domain found in carbohydrate-active enzymes. The majority of these domains have carbohydrate-binding activity. Some of these domains are found on cellulosomal scaffoldin proteins. CBMs were previously known as cellulose-binding domains. CBMs are classified into numerous families, based on amino acid sequence similarity. There are currently 64 families of CBM in the CAZy database.
Pfam PF02416: mttA/Hcf106 family (family)
Members of this protein family are involved in a sec independent translocation mechanism. This pathway has been called the DeltapH pathway in chloroplasts. Members of this family in E.coli are involved in export of redox proteins with a "twin arginine" leader motif.
Wikipedia: The twin-arginine translocation pathway is a protein export, or secretion pathway found in plants, bacteria, and archaea. In contrast to the Sec pathway which transports proteins in an unfolded manner, the Tat pathway serves to actively translocate folded proteins across a lipid membrane bilayer. In plants, the Tat translocase is located in the thylakoid membrane of the chloroplast, where it acts to export proteins into the thylakoid lumen. In bacteria, the Tat translocase is found in the cytoplasmic membrane and serves to export proteins to the cell envelope, or to the extracellular space. The existence of a Tat translocase in plant mitochondria is also proposed.
Pfam PF11195: Thoeris anti-defense 2-like domain (domain)
This entry represents Thoeris anti-defense 2 from Bacillus phage SP01 (Tad2) and similar sequences from tailed bacteriophages and bacterial prophages. Tad2 is an anti-defence protein that counteracts the host Thoeris antiviral defence system. It sequesters the immune signalling molecules produced by Thoeris TIR-domain proteins in response to phage infection. This entry also includes AcrIIA7 Cas9 inhibitor protein gene.
Pfam PF04037: Domain of unknown function (DUF382) (family)
This domain is specific to the human splicing factor 3b subunit 2 and it's orthologues. Splicing factor 3b subunit 2 or SAP145 is a suppressor of U2 snRNA mutations. Pre-mRNA splicing is catalysed by a large ribonucleoprotein complex called the spliceosome. Spliceosomes are multi-component enzymes that catalyse pre-mRNA splicing and form step-wise by the ordered interaction of UsnRNPs and non-snRNP proteins with short conserved regions of the pre-mRNA at the 5' and 3' splice sites and branch site.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF11589: Domain of unknown function (DUF3244) (domain)
This domain adopts an immunoglobulin-like beta-sandwich fold and structurally is most similar to fibronectin. This domain is found at the C-terminus of the Listeria monocytogenes InlP protein. This domain shares some similarity with the secretion signal domain of type X secretion systems [pfam:PF18962]. This domain is also found at the C-terminus of likely cell surface proteins suggesting this domain has a similar function.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF22470: H-NS histone-like proteins, N-terminal domain (domain)
This entry corresponds to the N-terminal oligomerisation domain of H-NS histone-like proteins.
Pfam PF20689: Bacterial Death-like domain 1 (domain)
This bacterial adaptor domain of the Death-domain fold is involved in protein-protein interactions in biological conflict systems. bDLDs show a characteristic architectural pattern. One copy is always fused, typically to the N- or C-terminus, of a core component of a biological conflict system; examples include VMAP and iSTAND. Further copies of the same bDLD are fused to either effector or signal-transducing domains, or additional Effector-associated domains (EADs). bDLD pairs are frequently observed together on the genome in conserved gene neighborhoods, but can also be severed from such neighborhoods and located in distant regions, indicating the bDLD-bDLD coupling approximates the advantages of collinear transcription.
Pfam PF19838: LptD protein (domain)
This entry likely represents the LptD homologue of Bacteriodetes bacteria. LptD is an essential outer membrane protein that mediates the final transport of lipopolysaccharide (LPS) to outer leaflet.
Pfam PF16618: Linker region between SH3 and WW domains on ARHGAP12 (disordered)
SH3-WW_linker is a natively unstructured region on Rho-GTPase activating factor 12 proteins that lies between the SH3 and the WW domains. it is found in higher eukaryotes, and the function is not known.
Pfam PF10515: Beta-amyloid precursor protein C-terminus (family)
This is the amyloid, C-terminal, protein of the beta-Amyloid precursor protein (APP) which is a conserved and ubiquitous transmembrane glycoprotein strongly implicated in the pathogenesis of Alzheimer's disease but whose normal biological function is unknown. The C-terminal 100 residues are released and aggregate into amyloid deposits which are strongly implicated in the pathology of Alzheimer's disease plaque-formation. The domain is associated with family A4_EXTRA, [pfam:PF02177], further towards the N-terminus.
Pfam PF10395: Utp8, N-terminal beta propeller (repeat)
This entry represents the N-terminal beta propeller of U3 small nucleolar RNA-associated protein 8 from Saccharomyces cerevisiae (Utp8) and similar proteins mainly found in fungi. Utp8 is an essential component of the nuclear tRNA export machinery in S.cerevisiae. It is a tRNA binding protein that acts at a step between tRNA maturation /aminoacylation, and translocation of the tRNA across the nuclear pore complex.
Pfam PF18464: Proprotein convertase subtilisin-like/kexin type 9 C-terminal domain (domain)
This entry represents a subdomain found in the C-terminal cysteine/histidine-rich domain (CRD) of PCSK9 (also known as neural apoptosis-regulated convertase, NARC-1). PCSK9 has been shown to regulate circulating LDL-R levels by controlling LDL-R degradation.  Furthermore, numerous mutations in the PCSK9 gene have been identified and associated with hypercholesterolemia (gain of function) or hypocholesterolemia (loss of function). The fully folded CRD, shows structural similarity to the resistin homotrimer, a small cytokine associated with obesity and diabetes. The C-terminal domain from PCSK9 consists of three, three-stranded beta-subdomains arranged in a pseudothreefold, and each of the subdomains in the CRD of PCSK9 consists of three structurally conserved disulfide bonds.
Pfam PF17228: Sulphur globule protein (family)
Sulphur globules are membrane-bounded intracellular globules, used by purple sulphur bacteria to transiently store sulphur during the oxidisation of reduced sulphur compounds. This proteobacterial family contains structural proteins of these sulphur globules, and includes sulphur globule protein CV1 (SgpA) and  sulphur globule protein CV2 (SgpB).
Pfam PF05211: Neuraminyllactose-binding hemagglutinin precursor (NLBH) (family)
This family is comprised of several flagellar sheath adhesin proteins also called neuraminyllactose-binding hemagglutinin precursor (NLBH) or N-acetylneuraminyllactose-binding fibrillar hemagglutinin receptor-binding subunits. NLBH is found exclusively in Helicobacter which are gut colonising bacteria and bind to sialic acid rich macromolecules present on the gastric epithelium.
Pfam PF13772: AIG2-like family (family)
This family is found in bacteria and metazoa.
Pfam PF20415: Family of unknown function (DUF6699) (family)
This entry represents a family of uncharacterised fungal proteins
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF17296: Arenavirus cap snatching domain (domain)
This domain represents the N-terminal domain of the Arenavirus polymerase that is involved in cap snatching during transcription initiation.
Pfam PF19639: Family of unknown function (DUF6142) (family)
This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 105 and 121 amino acids in length.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF02536: mTERF (family)
This family contains one sequence of known function  Human mitochondrial transcription termination factor (mTERF) the rest of the family consists of hypothetical proteins none of which have any functional information. mTERF is a multizipper protein possessing three putative leucine zippers one of which is bipartite. The protein binds DNA as a monomer.  The leucine zippers are not implicated in a dimerisation role as in other leucine zippers.
Pfam PF09273: Rubisco LSMT substrate-binding (domain)
Members of this family adopt a multihelical structure, with an irregular array of long and short alpha-helices. They allow binding of the protein to substrate, such as the N-terminal tails of histones H3 and H4 and the large subunit of the Rubisco holoenzyme complex.
Pfam PF10626: Conjugative transposon protein TraO (family)
This is a family of conjugative transposon proteins.
Pfam PF21141: Trehalose-6-phosphate phosphatase, C-terminal (domain)
This is the catalytic C-terminal domain of trehalose-6-phosphate phosphatase from parasitic nematodes such as Brugia malayi. This domain adopts a C2B-type HAD phosphatase fold. In C. elegans, T6PP is essential for survival due to the toxic effect(s) of the accumulation of trehalose 6-phosphate.
Pfam PF13116: YhdP protein (repeat)
This entry represents the Uncharacterized protein YhdP from E.coli and related proteins. Some members of this family are related to the AsmA family proteins.
Pfam PF02631: RecX, second three-helix domain (domain)
This entry represents the second three-helix domain (HTH-like) found in RecX family of proteins. RecX functions as a regulator of DNA recombination and repair pathways in bacterial cells. RecX protein is known to inhibit the activity of RecA protein in DNA recombination.
Pfam PF13079: Protein of unknown function (DUF3916) (family)
This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 170 amino acids in length. There is a single completely conserved residue S that may be functionally important.
Pfam PF18188: Prim-pol 4 (family)
Family of prim-pol enzymes with predicted roles in RNA processing and repair, potentially acting independently of a DNA template. One member of the family is fused to kinetoplastid DICER-like protein 1 (DCL1).
Pfam PF02462: Opacity family porin protein (family)
Pathogenic Neisseria spp. possess a repertoire of phase-variable Opacity proteins that mediate various pathogen--host cell interactions. These proteins are integral membrane proteins related to other porins.
Wikipedia: Opacity family porins are a family of porins from pathogenic Neisseria. 
These bacteria possess a repertoire of phase-variable opacity proteins that mediate various pathogen/host cell interactions. These proteins are related to OmpA-like transmembrane domain family.
Pfam PF17127: Domain of unknown function (DUF5106) (repeat)
This domain, found in Bacteroidetes proteins, is frequently associated with a putative thiol-disulfide oxidoreductase domain, [pfam:PF13905]. The function of this domain is not known.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF21693: Transcriptional protein SWT1, C-terminal domain (domain)
This domain is found at the C-terminal end of Transcriptional protein SWT1 from Saccharomyces cerevisiae and similar fungal proteins. SWT1 is an RNA endonuclease involved in quality control of nuclear messenger ribonucleoprotein particles (mRNPs). It consists of three domains: N-terminal, middle ([pfam:PF13638]), and C-terminal domain (this entry). This domain shows three long antiparallel helices and three shorter helices. It shares characteristics with members of the HEPN domain ([pfam:PF05168]).
Pfam PF20172: Domain of unknown function (DUF6538) (domain)
This short presumed domain is found at the N-terminus of a variety of phage integrase proteins.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF14316: Domain of unknown function (DUF4381) (family)
This family of proteins is found in bacteria and eukaryotes. Proteins in this family are typically between 158 and 180 amino acids in length.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF15346: Arginine and glutamate-rich 1 (coiled_coil)
ARGLU, arginine and glutamate-rich 1 protein family, is required for the oestrogen-dependent expression of ESR1 target genes. It functions in cooperation with MED1. The family of proteins is found in eukaryotes.
Pfam PF15830: Domain of unknown function (DUF4712) (family)
This family of proteins is found in eukaryotes. Proteins in this family are typically between 133 and 267 amino acids in length.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF09709: CRISPR-associated protein (Cas_Csd1) (family)
CRISPR loci appear to be mobile elements with a wide host range. This entry represents proteins that tend to be found near CRISPR repeats. The species range, so far, is exclusively bacterial and mesophilic, although CRISPR loci are particularly common among the archaea and thermophilic bacteria. Clusters of short DNA repeats with nonhomologous spacers, which are found at regular intervals in the genomes of phylogenetically distinct prokaryotic species, comprise a family with recognisable features. This family is known as CRISPR (short for Clustered, Regularly Interspaced Short Palindromic Repeats). A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins.
Pfam PF17557: I2-superfamily conotoxins (family)
Conotoxins (or conopeptides) are the peptidic components of the venoms of marine cone snails (genus Conus). They are classified in one of three ways: gene superfamily, cysteine framework or pharmacological family. Several distinct cysteine frameworks have been described in conotoxins. Members of this family display a XI cysteine pattern (C-C-CC-CC-C-C) and belong to the I2- superfamily conotoxins. Family members such as Kappa-conotoxin ViTx [swissprot:Q7YZS9] and Kappa-conotoxin SrXIA [swissprot:P0C615] inhibit voltage gated potassium channels (Kv).
Pfam PF05427: Acidic fibroblast growth factor binding (FIBP) (family)
Acidic fibroblast growth factor (aFGF) intracellular binding protein (FIBP) is a protein found mainly in the nucleus that is thought to be involved in the intracellular function of aFGF.
Pfam PF06074: Portal protein of Mu bacteriophage (family)
This entry represents phage portal proteins found in bacteriophage Mu (gp29 protein [swissprot:Q9T1W5]). This protein Forms the portal vertex of the capsid. This portal plays critical roles in head assembly, genome packaging, neck/tail attachment, and genome ejection. The portal protein multimerizes as a single ring-shaped homododecamer arranged around a central channel.
Pfam PF08021: Siderophore-interacting FAD-binding domain (domain)
Proteins in this entry are siderophore-interacting FAD-binding proteins.

This entry includes the vibriobactin utilization protein ViuB, which is involved in the removal of iron from iron-vibriobactin complexes, as well as several hypothetical proteins.
Pfam PF16397: Domain of unknown function (DUF5006) (family)
This small family of proteins is functionally uncharacterised. This family is found in bacteroides. Proteins in this family are around 600 amino acids in length.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF18918: Family of unknown function (DUF5669) (family)
This is a family of unknown function. Family members are mostly found in gammaproteobacteria.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF10391: Fingers domain of DNA polymerase lambda (domain)
DNA polymerases catalyse the addition of dNMPs onto the 3-prime ends of DNA chains. There is a general polymerase fold consisting of three subdomains that have been likened to the fingers, palm, and thumb of a right hand. DNA_pol_lambd_f is the central three-helical region of DNA polymerase lambda referred to as the F and G helices of the fingers domain. Contacts with DNA involve this conserved helix-hairpin-helix motif in the fingers region which interacts with the primer strand. This motif is common to several DNA binding proteins and confers a sequence-independent interaction with the DNA backbone.
Pfam PF05762: VWA domain containing CoxE-like protein (family)
This family is annotated by SMART as containing a VWA (von Willebrand factor type A) domain.  The exact function of this family is unknown.  It is found as part of a CO oxidising (Cox) system operon is several bacteria.