SII-SWORD/CoKE huggingface dataset:
Pfam PF09323: DUF1980 N-terminal domain (domain)
Members of this family are found in a set of prokaryotic hypothetical proteins. Their exact function, has not, as yet, been defined. This entry represents the N-terminal 3-transmembrane helical domain.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF00533: BRCA1 C Terminus (BRCT) domain (domain)
The BRCT domain is found predominantly in proteins involved in cell cycle checkpoint functions responsive to DNA damage.  The BRCT domain of XRCC1 forms a homodimer in the crystal structure. This suggests that pairs of BRCT domains associate as homo- or heterodimers. BRCT domains are often found as tandem-repeat pairs. Structures of the BRCA1 BRCT domains revealed a basis for a widely utilised head-to-tail BRCT-BRCT oligomerisation mode. This conserved tandem BRCT architecture facilitates formation of the canonical BRCT phospho-peptide interaction cleft at a groove between the BRCT domains. Disease associated missense and nonsense mutations in the BRCA1 BRCT domains disrupt peptide binding by directly occluding this peptide binding groove, or by disrupting key conserved BRCT core folding determinants.
Wikipedia: BRCA1 C Terminus (BRCT) domain  is a family of evolutionarily related proteins. It is named after the C-terminal domain of BRCA1, a DNA-repair protein that serves as a marker of breast cancer susceptibility.
Pfam PF08260: Insect kinin peptide (family)
These neuropeptides are the first members of the insect kinin-family isolated from the American cockroach. Their occurrence in the retrocerebral complex suggests a physiological role as a neurohormone. The C-terminal sequence Phe-X-Ser-Trp-Gly-NH2 characterised the peptides as members of the insect kinin family.  Data suggest a possible involvement of insect kinins in water-balance by regulating the osmoregulation. These peptides have length from 6 to 14 amino acids.
Pfam PF03702: Anhydro-N-acetylmuramic acid kinase (family)
Anhydro-N-acetylmuramic acid kinase catalyses the specific phosphorylation of 1,6-anhydro-N-acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. It is also required for the utilization of anhMurNAc, either imported from the medium, or derived from its own cell wall murein, and in so doing plays a role in cell wall recycling.
Pfam PF08486: Stage II sporulation protein (family)
This domain is found in the stage II sporulation protein SpoIID. SpoIID is necessary for membrane migration as well as for some of the earlier steps in engulfment during bacterial endospore formation.  The domain is also found in amidase enhancer proteins.  Amidases, like SpoIID, are cell wall hydrolases.
Pfam PF03595: Voltage-dependent anion channel (family)
This family of transporters has ten alpha helical transmembrane segments.  The structure of a bacterial homologue of SLAC1 shows it to have a trimeric arrangement. The pore is composed of five helices with a conserved Phe residue involved in gating. One homologue, Mae1 from the yeast Schizosaccharomyces pombe, functions as a malate uptake transporter; another, Ssu1 from Saccharomyces cerevisiae and other fungi including Aspergillus fumigatus, is characterised as a sulfite efflux pump; and TehA from Escherichia coli is identified as a tellurite resistance protein by virtue of its association in the tehA/tehB operon. In plants, this family is found in the stomatal guard cells functioning as an anion-transporting pore. Many homologues are incorrectly annotated as tellurite resistance or dicarboxylate transporter (TDT) proteins.
Wikipedia: Two members of the Tellurite-Resistance/Dicarboxylate Transporter (TDT) family have been functionally characterised. One is the TehA protein of Escherichia coli which has been implicated in resistance to tellurite; the other is the Mae1 protein of Schizosaccharomyces pombe which functions in the uptake of malate and other dicarboxylates by a proton symport mechanism. These proteins have 10 putative transmembrane helices.
Pfam PF24199: Domain of unknown function (DUF7424) (domain)
This entry represents a family of uncharacterised lipoproteins. The family includes a range of both bacteria and phage proteins.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF16862: Glycosyl hydrolase family 79 C-terminal beta domain (domain)
This domain is found at the C-terminus of glycosyl hydrolase family 79 proteins. It's function is not yet known.
Pfam PF02798: Glutathione S-transferase, N-terminal domain (domain)
Function: conjugation of reduced glutathione to a variety of targets. Also included in the alignment, but not GSTs: S-crystallins from squid (similarity to GST previously noted); eukaryotic elongation factors 1-gamma (not known to have GST activity and similarity not previously recognised); HSP26 family of stress-related proteins including auxin-regulated proteins in plants and stringent starvation proteins in E. coli (not known to have GST activity and similarity not previously recognised). The glutathione molecule binds in a cleft between the N- and C-terminal domains - the catalytically important residues are proposed to reside in the N-terminal domain.
Wikipedia: Glutathione S-transferases (GSTs), previously known as ligandins, are a family of eukaryotic and prokaryotic phase II metabolic isozymes best known for their ability to catalyze the conjugation of the reduced form of glutathione (GSH) to xenobiotic substrates for the purpose of detoxification. The GST family consists of three superfamilies: the cytosolic, mitochondrial, and microsomal—also known as MAPEG—proteins. Members of the GST superfamily are extremely diverse in amino acid sequence, and a large fraction of the sequences deposited in public databases are of unknown function. The Enzyme Function Initiative (EFI) is using GSTs as a model superfamily to identify new GST functions.
Pfam PF08753: NikR C terminal nickel binding domain (domain)
NikR is a transcription factor that regulates nickel uptake. It consists of two dimeric DNA binding domains separated by a tetrameric regulatory domain that binds nickel.  This domain corresponds to the C terminal regulatory domain which contains four nickel binding sites at the tetramer interface.
Pfam PF24611: Nuclear anchorage protein 1, spectrin-like repeat (domain)
This entry represents spectrin-like repeats found in Nuclear anchorage protein 1 from Caenorhabditis elegans, which plays a central role in nuclear and mitochondrial anchoring.
Pfam PF02340: PRRSV putative envelope protein (family)
This family consists of a conserved probable envelope protein or ORF2 in porcine reproductive and respiratory syndrome virus (PRRSV) also in the family is a minor structural protein from lactate dehydrogenase-elevating virus.
Pfam PF21938: CAP, N-terminal domain (domain)
Cyclase-associated proteins (CAPs) are highly conserved actin-binding proteins present in a wide range of organisms including yeast, fly, plants, and mammals. CAPs are multifunctional proteins that regulate actin remodelling in response to cellular signals. They consist of an N-terminal conserved motif ([pfam:PF01213]) followed by an N-terminal and C-terminal domains which are separated by a Pro-rich region. This entry represents the N-terminal domain which contains the adenylyl cyclase binding site and has an all-alpha structure consisting of six helices in a bundle with a left-handed twist and up-and-down topology.
Pfam PF12045: Protein of unknown function (DUF3528) (family)
This family of proteins is functionally uncharacterised. This protein is found in eukaryotes. Proteins in this family are typically between 185 to 298 amino acids in length. This protein is found associated with [pfam:PF00046].
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF05636: HIGH Nucleotidyl Transferase (family)
This family consists of HIGH Nucleotidyl Transferases
Pfam PF03260: Lepidopteran low molecular weight (30 kD) lipoprotein (family)
This family includes Lepidopteran low molecular weight (30kDa) lipoproteins (30KPs), which belong to the Lipoprotein 11 family. They are abundant proteins found in the hemolymph, mainly synthesized in the fat body and then secreted into the hemolymph during the last instar larval stage. They have very similar amino acid and nucleotide sequences which are also similar to those of microvitellogenin in Manduca sexta . Structure resolution of some of its members revealed that they belong to the Î²-sheet superfamily and share a characteristic fold, with differences in loop conformations thought to confer ligand specificity .

Studies from Bombyx mori, showed that these proteins function as storage proteins during growth and development but they are used only during embryonic development, thought to act as storage units of amino acids for use in de novo synthesis of other proteins. They are also involved in energy transport and metabolic processes such as release of diacylglycerol and the transport of steroids and hormones. 30KPs may be involved in defense response mechanisms as they can be conjugated to glucose, dextran, maltose and glycoproteins . These proteins may also inhibit apoptosis, thereby having a role in cell survival .
Pfam PF19168: Family of unknown function (DUF5850) (family)
This is a family of uncharacterised proteins of unknown function predominantly found in Iridoviridae. The family contains a conserved motif towards the C-terminus of these proteins. This motif contains a central RGD sequence which suggests these viral proteins may bind to integrins.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF19158: Family of unknown function (DUF5840) (family)
This family contains uncharacterised proteins. It also contains the anacyclamide synthesis protein AcyE. Cyanobactins are small, cyclic peptides found in cyanobacteria. They are ribosomally synthesised and post-translationally modified. Cyanobactin biosynthesis clusters contain 7-12 genes. Anaclyclamides are a  type of cyanobactin produced in strains of the cyanobacteria Anabaena. AcyE is a 49-amino-acid protein with N-terminal homology to the peptide precursor proteins in the other cyanobactin  pathways. The core peptide of AcyE is cleaved during  post-translational processing of the precursor peptide.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF15722: FAM153 family (family)
This family of proteins is found in eukaryotes. Proteins in this family are typically between 109 and 289 amino acids in length.
Pfam PF06049: Coagulation Factor V LSPD Repeat (disordered)
These repeats are found in coagulation factor V (five). The name LSPD derives from the conserved residues in the middle of the repeat.They occur in the B domain, which is cleaved prior to activation of the protein. It has been suggested that domain B bring domains A and C together for activation ().
Pfam PF09118: Galactose oxidase-like, Early set domain (domain)
E or 'early' set domains are associated with the catalytic domain of galactose oxidase at the C-terminal end. Galactose oxidase is an extracellular monomeric enzyme which catalyzes the stereospecific oxidation of a broad range of primary alcohol substrates, and possesses a unique mononuclear copper site essential for catalysing a two-electron transfer reaction during the oxidation of primary alcohols to corresponding aldehydes. The second redox active centre necessary for the reaction was found to be situated at a tyrosine residue. The C-terminal domain of galactose oxidase may be related to the immunoglobulin and/or fibronectin type III superfamilies. These domains are associated with different types of catalytic domains at either the N-terminal or C-terminal end, and may be involved in homodimeric/tetrameric/dodecameric interactions.  Members of this family adopt a secondary structure consisting of a bundle of seven, mostly antiparallel, beta-strands surrounding a hydrophobic core. The 7 strands are arranged in 2 sheets, in a Greek-key topology. This domain is found in sugar-utilising enzymes, such as galactose oxidase or chitinase.
Pfam PF20298: Prokaryotic E2 domain (domain)
This is an E2 domain observed in certain prokaryotic Ubiquitin systems found as secondary effectors in nucleotide-activated effector conflict systems.
Pfam PF12117: Parvovirus non-structural protein 1, C-terminal (domain)
This domain is the transactivation domain of the Parvovirus NS1 protein, located immediately C-terminal to the helicase. Parvovirus are some of the smallest viruses containing linear, non-segmented single-stranded DNA genomes, with an average genome size of 5000 nucleotides. They infect a wide range of invertebrates and vertebrates and are well known for causing enteric disease in mammals. Genomes contain two large ORFs: NS1 and VP1; other ORFs are found in some sub-types and different gene products can arise from splice variants and the use of different start codons. NS1 protein is essential for viral life cycle stages, including DNA replication, trans-regulation of the two viral promoters and modulation of heterologous promoters. It exhibits DNA binding, endonuclease and helicase activities and is the major contributor to the toxic effect on host cells.
Pfam PF08669: Glycine cleavage T-protein C-terminal barrel domain (domain)
This is a family of glycine cleavage T-proteins, part of the glycine  cleavage multienzyme complex (GCV) found in bacteria and the mitochondria of eukaryotes. GCV catalyses the catabolism of glycine in eukaryotes. The T-protein is an aminomethyl transferase.
Wikipedia: The glycine cleavage system (GCS) is also known as the glycine decarboxylase complex or GDC. The system is a series of enzymes that are triggered in response to high concentrations of the amino acid glycine. The same set of enzymes is sometimes referred to as glycine synthase when it runs in the reverse direction to form glycine. The glycine cleavage system is composed of four proteins: the T-protein, P-protein, L-protein, and H-protein. They do not form a stable complex, so it is more appropriate to call it a "system" instead of a "complex". The H-protein is responsible for interacting with the three other proteins and acts as a shuttle for some of the intermediate products in glycine decarboxylation. In both animals and plants, the glycine cleavage system is loosely attached to the inner membrane of the mitochondria. Mutations in this enzymatic system are linked with glycine encephalopathy.
Pfam PF10510: Phosphatidylinositol-glycan biosynthesis class S protein (family)
PIG-S is one of several key, core, components of the glycosylphosphatidylinositol (GPI) trans-amidase complex that mediates GPI anchoring in the endoplasmic reticulum. Anchoring occurs when a protein's C-terminal GPI attachment signal peptide is replaced with a pre-assembled GPI. Mammalian GPITransamidase consists of at least five components: Gaa1, Gpi8, PIG-S, PIG-T, and PIG-U, all five of which are required for function. It is possible that Gaa1, Gpi8, PIG-S, and PIG-T form a tightly associated core that is only weakly associated with PIG-U.  The exact function of PIG-S is unclear.
Pfam PF09825: Biotin-protein ligase, N terminal (domain)
The function of this structural domain is unknown. It is found to the N terminus of the biotin protein ligase (BPL) catalytic domain. This domain is essential in BPL activity.
Pfam PF23394: Domain of unknown function (DUF7102) (domain)
This domain has a restriction endonuclease-like fold. The function of these proteins is unknown. Some members of the family are annotated as nucleoporins.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF15623: Cancer/testis gene family 47 (family)
CT47 is a family of proteins found in eukaryotes. Proteins in this family are typically between 262 and 291 amino acids in length. There is a conserved HIL sequence motif. The function of this family is not known.
Pfam PF01297: Zinc-uptake complex component A periplasmic (family)
ZnuA includes periplasmic solute binding proteins such as TroA that interacts with an ATP-binding cassette transport system in Treponema pallidum. ZnuA is part of the bacterial zinc-uptake complex ZnuABC, whose components are the following families, ZinT, [pfam:PF09223], [pfam:PF00950], [pfam:PF00005], all of which are regulated by the transcription-regulator family FUR, [pfam:PF01475]. ZinT acts as a Zn2+-buffering protein that delivers Zn2+ to ZnuA (TroA), a high-affinity zinc-uptake protein.  In Gram-negative bacteria the ZnuABC transporter system ensures an adequate import of zinc in Zn2+-poor environments, such as those encountered by pathogens within the infected host.
Pfam PF24575: Surface lipoprotein assembly modifier, N-terminal TPR repeats (repeat)
This is a region of tetratricopeptide repeats (TPR) found at the N-terminal of Surface lipoprotein assembly modifier from the proteobacteria Pasteurella multocida (Slam) and similar sequences. Slam plays a role in the export to the cell surface of some cell outer membrane lipoproteins.
Pfam PF01946: Thi4 family (family)
This family includes [swissprot:P32318] a putative thiamine biosynthetic enzyme.
Pfam PF17730: Centrosomal C10orf90 (family)
This is the N-terminal region found on proteins encoded by C10orf90. Most of the family members carry ALMS motif on their C-terminal [pfam:PF15309].SiRNA mediated functional analysis suggest that the C10orf90 encoded proteins have a role in centrosomal functions.
Pfam PF12724: Flavodoxin domain (domain)
This is a family of flavodoxins.  Flavodoxins are electron transfer proteins that carry a molecule of non-covalently bound FMN.
Pfam PF09111: SLIDE (domain)
The SLIDE domain adopts a secondary structure comprising a main core of three alpha-helices. It has a role in DNA binding, contacting DNA target sites similar to c-Myb ([pfam:PF00249]) repeats or homeodomains.
Pfam PF22524: Nlrc4-like, winged helix domain (domain)
This entry represents the winged helix domain (WHD) of NLR family CARD domain-containing protein 4 from mouse (Nlrc4) and similar sequences from vertebrates. Nlrc4 is a component of the inflammasome activated as part of the innate immune response.
Pfam PF07343: Protein of unknown function (DUF1475) (family)
This family consists of several hypothetical plant proteins of around 250 residues in length. Members of this family seem to be found exclusively in Arabidopsis thaliana. The function of this family is unknown.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF11397: Glycosyltransferase (GlcNAc) (family)
GlcNAc is an enzyme that carries out the first glycosylation step of hydroxylated Skp1, a ubiquitous eukaryotic protein, in the cytoplasm.
Pfam PF16075: Domain of unknown function (DUF4815) (family)
This domain is found in viral and bacterial proteins. Its function is not known.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF02002: TFIIE alpha subunit (family)
The general transcription factor TFIIE has an essential role in eukaryotic transcription initiation together with RNA polymerase II and other general factors. Human TFIIE consists of two subunits TFIIE-alpha [swissprot:P29083] and TFIIE-beta [swissprot:P29084] and joins the pre-initiation complex after RNA polymerase II and TFIIF. This family consists of the conserved amino terminal region of eukaryotic TFIIE-alpha and proteins from archaebacteria that are presumed to be TFIIE-alpha subunits also [swissprot:O29501].
Pfam PF12094: Protein of unknown function (DUF3570) (family)
This family of proteins is functionally uncharacterised. This protein is found in bacteria. Proteins in this family are typically between 396 to 444 amino acids in length. Proteins in this family contain the [S/T]GA[S/T] motif and thus, is flavinylated by ApbE. This suggests that they may be involved in extracytosolic redox activities.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF22535: Family of unknown function (DUF7003) (family)
This is a family of uncharacterised bacterial proteins. It is predicted to adopt a globular alpha/beta structure with a central antiparallel beta-sheet and helices packed on it.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.