SII-SWORD/CoKE huggingface dataset:
Pfam PF19070: Family of unknown function (DUF5766) (family)
This is a family of uncharacterised proteins of unknown function found in viruses.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF20675: Maintenance of Photosystem II under High light 2 (family)
This is a family of chloroplast thylakoid lumenal proteins, including Maintenance of Photosystem II under High light 2 (also known as Thylakoid lumenal 16.5 kDa protein, [swissprot:O22773]) encoded by At4g02530 in Arabidopsis thaliana. MPH2 is required for the adaptation of this organism to photoinhibitory light and fluctuating light environments.
Pfam PF10379: Virulence protein nec1 (family)
This is a family of virulence proteins that are found in pathogenic Streptomyces species.
Pfam PF23379: Domain of unknown function (DUF7096) (domain)
This domain is found at the N-terminal end of a group of proteins from eubacteria. It is predicted to show a mainly alpha-configuration. This entry is found associated with [pfam:PF23375] and [pfam:PF23374]
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF21031: WDR54 (repeat)
WDR54 has a regulatory effect on ERK signaling pathway activity in response to EGF stimulation, when is cross-linked to form dimers and trimers. It colocalizes with the EGF receptor in a WDR54-specific vesicle where it sustains the internalisation and controls the degradation of the EGF receptor after EGF stimulation.
Pfam PF02223: Thymidylate kinase (domain)
This entry represents a domain found in thymidylate kinase and mitochondrial UMP-CMP kinase.
Thymidylate kinase (2.7.4.9; dTMP kinase) catalyses the phosphorylation of thymidine 5'-monophosphate (dTMP) to form thymidine 5'-diphosphate (dTDP) in the presence of ATP and magnesium:

ATP + thymidine 5'-phosphate = ADP + thymidine 5'-diphosphate

Thymidylate kinase is an ubiquitous enzyme of about 25 Kd and is important in the dTTP synthesis pathway for DNA synthesis. The function of dTMP kinase in eukaryotes comes from the study of a cell cycle mutant, cdc8, in Saccharomyces cerevisiae. Structural and functional analyses suggest that the cDNA codes for authentic human dTMP kinase. The mRNA levels and enzyme activities corresponded to cell cycle progression and cell growth stages .
From a phylogenetic analysis, human mitochondrial UMP-CMP kinase has been shown to be closer to thymidylate kinase than to cytosolic UMP-CMP kinase. It phosphorylates dUMP, dCMP, CMP, and UMP with ATP as phosphate donor .
Wikipedia: Thymidylate kinase catalyzes the phosphorylation of thymidine 5'-monophosphate (dTMP) to form thymidine 5'-diphosphate (dTDP) in the presence of ATP and magnesium:ATP + thymidine 5'-phosphate  ADP + thymidine 5'-diphosphate
Pfam PF21365: Glycosyl hydrolase family 31 C-terminal domain (domain)
Glycosyl hydrolases are key enzymes of carbohydrate metabolism. Family 31 comprises of enzymes that are, or similar to, alpha- galactosidases. This entry represents the 3rd beta sandwich domain.
Wikipedia: In molecular biology, glycoside hydrolase family 31 is a family of glycoside hydrolases.
Pfam PF15660: Putative Immunity protein 75 (family)
This family is highly conserved suggesting it might derive from a phage protein. Members are less than 90 residues in length, and the function is not known.
Pfam PF15734: Migration and invasion-inhibitory (family)
This family of proteins binds to insulin-like growth factor binding protein 2 (IGFBP-2) and inhibits the invasion of glioma cells.
Pfam PF01851: Proteasome/cyclosome repeat (repeat)
A weakly conserved repeat module of unknown function, which occurs in two regulatory subunits of the 26S-proteasome and in one subunit of the anaphase-promoting complex .
Pfam PF21594: Maternal embryonic leucine zipper kinase, UBA domain (domain)
This domain is found in Maternal embryonic leucine zipper kinase from humans (MELK) and similar proteins from animals. MELK is a member of the snf1/AMPK family of serine-threonine kinases that has been associated with various cellular processes, including stem cell renewal, cell cycle progression, and pre-mRNA splicing. It is upregulated in several types of tumour. MELK is organised into three domains: an N-terminal kinase domain ([pfam:PF00069]), a ubiquitin associated (UBA) domain (this entry) and a C-terminal kinase associated domain (KA1, [pfam:PF02149]). This domain adopts a compact configuration consisting of three alpha-helices organised in a "U"-shaped fold, with the first helix antiparallel to the third one.
Pfam PF20721: C19orf12-like protein (family)
This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and eukaryotes. Proteins in this family are approximately 140 amino acids in length. This family includes the human protein C19orf12. These proteins contain a glycine zipper motif.
Pfam PF23963: Family of unknown function (DUF7291) (family)
This entry represents a small family of uncharacterised phage proteins. A structure prediction suggests this protein forms a compact alpha helical domain followed by a disordered region.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF05254: Uncharacterised protein family (UPF0203) (family)
This family of proteins is functionally uncharacterised.
Pfam PF13118: Protein of unknown function (DUF3972) (family)
This is a Proteobacterial family of unknown function.  Some of the proteins in this family are annotated as being kinesin-like proteins.
Pfam PF20167: Putative plant transposon protein (family)
This entry represents a likely transposon related protein from plants. This entry appears related to ORF1 from the ATHILA group of Arabidopsis thaliana retrotransposons [pfam:PF03078].
Pfam PF06005: Cell division protein ZapB (coiled_coil)
ZapB is a non-essential, abundant cell division factor that is required for proper Z-ring formation.
Pfam PF23827: Family of unknown function (DUF7197) (family)
This entry represents a domain of unknown function. It is typically between 120 and 250 amino acids in length.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF17739: Family of unknown function (DUF5576) (family)
This is a family of unknown function found in Hominidae.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF12645: Helix-turn-helix domain (domain)
This domain appears to be a helix-turn-helix domain suggesting that this might be a transcriptional regulatory protein. Some members of this family are annotated as conjugative transposon domains.
Wikipedia: Helix-turn-helix is a DNA-binding domain (DBD). The helix-turn-helix (HTH) is a major structural motif capable of binding DNA. Each monomer incorporates two α helices, joined by a short strand of amino acids, that bind to the major groove of DNA. The HTH motif occurs in many proteins that regulate gene expression. It should not be confused with the helix–loop–helix motif.
Pfam PF17269: Family of unknown function (DUF5335) (family)
This bacterial family of proteins has no known function.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF02324: Glycosyl hydrolase family 70 (family)
Members of this family belong to glycosyl hydrolase family 70 Glucosyltransferases or sucrose 6-glycosyl transferases (GTF-S) catalyse the transfer of D-glucopyramnosyl units from sucrose  onto acceptor molecules, [ec:2.4.1.5].  This family roughly corresponds to the N-terminal catalytic domain of the enzyme. Members of this family also contain the Putative cell wall binding domain [pfam:PF01473], which corresponds with the C-terminal glucan-binding domain.
Wikipedia: In molecular biology, glycoside hydrolase family 70 is a family of glycoside hydrolases.
Pfam PF12867: DinB superfamily (domain)
The DinB family are an uncharacterised family of potential enzymes. The structure of these proteins is composed of a four helix bundle.
Pfam PF08663: HalX domain (domain)
HalX is a domain of unknown function, previously (mis)annotated as HoxA-like transcriptional regulator.
Pfam PF12412: Protein of unknown function (DUF3667) (family)
This domain family is found in bacteria and eukaryotes, and is approximately 50 amino acids in length. There is a single completely conserved residue P that may be functionally important.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF05424: Duffy binding domain (family)
This domain is found in Plasmodium Duffy binding proteins. Plasmodium vivax and Plasmodium knowlesi merozoites invade human erythrocytes that express Duffy blood group surface determinants. The Duffy receptor family is localised in micronemes, an organelle found in all organisms of the phylum Apicomplexa. This family is closely associated on PfEMP1 proteins with PFEMP, [pfam:PF03011].
Wikipedia: In molecular biology, Duffy binding proteins are found in Plasmodium. Plasmodium vivax and Plasmodium knowlesi merozoites invade Homo sapiens erythrocytes that express Duffy blood group surface determinants. The Duffy receptor family is localised in micronemes, an organelle found in all organisms of the phylum Apicomplexa.
Pfam PF04576: Zein-binding (coiled_coil)
This domain binds to zein proteins, [pfam:PF01559]. Zein proteins are seed storage proteins.
Pfam PF10465: PinA peptidase inhibitor (family)
PinA inhibits the endopeptidase La.  It binds to the La homotetramer but does not interfere with the ATP binding site or the active site of La.
Wikipedia: In biology and biochemistry, protease inhibitors, or antiproteases, are molecules that inhibit the function of proteases. Many naturally occurring protease inhibitors are proteins.
Pfam PF09703: CRISPR-associated protein (Cas_Csa4) (family)
CRISPR loci appear to be mobile elements with a wide host range. This entry represents a protein that tends to be found near CRISPR repeats. The species range for this species, so far, is exclusively archaeal. It is found so far in only four different species, and includes two tandem genes in Pyrococcus furiosus DSM 3638. CRISPR is a term for Clustered, Regularly Interspaced Short Palindromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins.
Pfam PF06391: CDK-activating kinase assembly factor MAT1 (family)
MAT1 is an assembly/targeting factor for cyclin-dependent kinase-activating kinase (CAK), which interacts with the transcription factor TFIIH.  The domain found to the N-terminal side of this domain is a C3HC4 RING finger.
Pfam PF19597: Conjugal transfer protein TrbL (family)
This family includes conjugal transfer proteins predominantly found in Firmicutes. Proteins in this family are typically between 198 and 292 amino acids in length.
Pfam PF18926: 2TM family of unknown function (DUF5676) (family)
This family of presumed integral membrane proteins is found in bacteria and archaea. Proteins in this family are approximately 90 amino acids in length and contain two predicted transmembrane helices.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF24341: P-granule-associated protein DEPS-1, sixth OB-fold domain (domain)
This domain is found in the P-granule-associated protein DEPS-1 from C.elegans and related proteins. DEPS-1 is a component of the P-granules and is required for their formation and integrity in adult germ cells. This protein is also involved in RNA-mediated silencing (RNAi) of germline-expressed genes. DEPS-1 is predicted to contain six OB-fold-like beta-barrel domains. This entry represents the sixth of these domains.
Pfam PF09972: Predicted membrane protein (DUF2207) N-terminal domain (domain)
This domain, found in various hypothetical bacterial proteins, has no known function.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF21436: STT3/PglB/AglB core domain (domain)
This entry represents the C-terminal core domain found in the oligosaccharyl transferase STT3 subunit and related proteins, such as bacterial PglB and archaeal AlgB. STT3 is part of the oligosccharyl transferase (OTase) complex and required for its activity, which transfers a lipid-linked core-oligosaccharide to selected asparagine residues in the ER. In the archaea STT3 occurs alone, rather than in an OTase complex,  and is required for N-glycosylation of asparagines. This is a globular domain which adopts a mixed alpha/beta fold and contains the highly conserved WWDYG motif, in which the aspartate residue is thought to function as a catalytic residue.
Pfam PF01721: Class II bacteriocin (family)
The bacteriocins are small peptides that inhibit the growth of various bacteria. Bacteriocins of lactic acid  bacteria may inhibit their target cells by permeabilising the cell  membrane.
Wikipedia: Class II bacteriocins  are a class of small peptides that inhibit the growth of various bacteria.
Pfam PF13962: Domain of unknown function (domain)
The PGG domain is named for the highly conserved sequence motif found at the startt of the domain. The function is not known.
Pfam PF08253: Erm Leader peptide (family)
These short proteins are Leader peptides (15-19 amino acids) of erm genes that code for resistance determinants in Staphylococcus  aureus.
Pfam PF07467: Beta-lactamase inhibitor (BLIP) (family)
The structure of BLIP reveals two structural domains, which form a polar, concave surface that docks onto a predominantly polar, convex protrusion on beta-lactamase. The ability of BLIP to adapt to a variety of class A beta-lactamases is thought to be due to flexibility between these two domains.
Wikipedia: Beta-Lactamase Inhibitor Proteins (BLIPs) are a family of proteins produced by bacterial species including Streptomyces. BLIP acts as a potent inhibitor of beta-lactamases such as TEM-1, which is the most widespread resistance enzyme to penicillin antibiotics. BLIP binds competitively the surface of TEM-1 and inserting residues into the active site to make direct contacts with catalytic residues. BLIP is able to inhibit a variety of class A beta-lactamases, possibly through flexibility of its two domains. The two tandemly repeated domains of BLIP have an α2-β4 structure, the β-hairpin loop from domain 1 inserting into the active site of beta-lactamase. BLIP shows no sequence similarity with BLIP-II, even though both bind to and inhibit TEM-1.
Pfam PF03372: Endonuclease/Exonuclease/phosphatase family (domain)
This large family of proteins includes magnesium dependent endonucleases and a large number of phosphatases involved in intracellular signalling. This family includes: AP endonuclease proteins [ec:4.2.99.18] e.g [swissprot:P27695], DNase I proteins [ec:3.1.21.1] e.g. [swissprot:P24855], Synaptojanin an inositol-1,4,5-trisphosphate phosphatase [ec:3.1.3.56] [swissprot:O43426], Sphingomyelinase [ec:3.1.4.12] [swissprot:P11889] and Nocturnin [swissprot:O35710].
Wikipedia: Endonuclease/Exonuclease/phosphatase family is a structural domain found in the large family of proteins including magnesium dependent endonucleases and many phosphatases involved in intracellular signaling.
Pfam PF11805: Protein of unknown function (DUF3326) (family)
This protein is functionally uncharacterized. It is about 300-500 amino acids in length.  This family is found in plants and bacteria.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF17674: HHH domain (domain)
This domain is part of a pfam clan of helix-hairpin-helix DNA-binding domains.
Pfam PF24916: Fungal GCN1-like, HEAT repeats (repeat)
This region of HEAT repeats is found in eIF-2-alpha kinase activator GCN1 from Saccharomyces cerevisiae and similar fungal sequences. GCN1 is a ribosome collision sensor that activates a translation quality control pathway when a ribosome has stalled during translation.
Pfam PF23092: Neuron navigator 1-like, ubiquitin-like domain (domain)
This domain is found in human Neuron navigator 1 (NAV1) and similar sequences from animals. NAV1 may be involved in neuronal migration. This domain is predicted to adopt a ubiquitin-like fold.
Pfam PF24037: Family of unknown function (DUF7346) (family)
This entry represents uncharacterised archaeal sequences containing a presumed HTH domain.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF12924: Copper-binding of amyloid precursor, CuBD (domain)
This short domain, part of the extra-cellular N-terminus of the amyloid precursor protein, APP, can bind both copper and zinc, CuBD.  The structure of Cu2+-bound CuBD reveals that the metal ligands are His147, His151, Tyr168 and two water molecules, which are arranged in a square pyramidal geometry. The structure of Cu+-bound CuBD is almost identical to the Cu2+-bound structure except for the loss of one of the water ligands. The geometry of the site is unfavourable for Cu+, thus providing a mechanism by which CuBD could readily transfer Cu ions to other proteins.
Pfam PF21392: Ubiquinone biosynthesis protein COQ9, N-terminal domain (domain)
This domain is found at the N-terminal end of Ubiquinone biosynthesis protein COQ9 from humans and similar proteins predominantly from vertebrates. COQ9 is a lipid-binding protein involved in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration.  This protein has structural homology to the TFR family of bacterial transcriptional regulators. This domain contains an a helix-turn- helix (HTH) motif that largely lacks the positive charges required for DNA binding.
Pfam PF20539: Domain of unknown function (DUF6754) (domain)
This presumed domain is functionally uncharacterised. This domain family is found in bacteria, and is approximately 250 amino acids in length.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF22018: LPP20 lipofamily protein, middle domain (domain)
This domain is found in LPP20 lipofamilyprotein [swissprot:K2KM35] from from Helicobacter pylori (HP1454) and similar sequences mainly found in epsilonproteobacteria. HP1454 is a secreted protein composed of three distinct domains: the N-terminal [pfam:PF02169], this domain and the C-terminal [pfam:PF22017]. This domain forms an anti-parallel three-helix bundle.
Pfam PF22737: NACHT N-terminal Helical domain 6 (domain)
This is the helical domain found at the N-terminus of bacterial NACHT conflict systems. This position is frequently occupied by an effector domain.
Pfam PF02309: AUX/IAA family (family)
Transcription of the AUX/IAA family of genes is rapidly induced by the plant hormone auxin. Some members of this family are longer and contain an N terminal DNA binding domain, such as [swissprot:O64965]. The function of this region is uncertain.
Pfam PF08366: LLGL2 (repeat)
This domain is found in lethal giant larvae homolog 2 (LLGL2) proteins and syntaxin-binding proteins like tomosyn.  It has been identified in eukaryotes and tends to be found together with WD repeats ([pfam:PF00400]).
Pfam PF08969: USP8 dimerisation domain (domain)
This domain is predominantly found in the amino terminal region of Ubiquitin carboxyl-terminal hydrolase 8 (USP8). It forms a five helical bundle that dimerises.
Pfam PF14376: Haem-binding domain (family)
This domain contains a potential haem-binding motif, CXXCH. This family is found in association with [pfam:PF00034] and [pfam:PF03150].