SII-SWORD/CoKE huggingface dataset:
Pfam PF05657: Protein of unknown function (DUF806) (family)
This family consists of several Siphovirus and Lactococcus proteins of unknown function. The viral sequences are thought to be tail component proteins.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF10523: BEN domain (domain)
The BEN domain is found in diverse animal proteins such as BANP/SMAR1, NAC1 and the Drosophila mod(mdg4) isoform C, in the chordopoxvirus virosomal protein E5R and in several proteins of polydnaviruses. Computational analysis suggests that the BEN domain mediates protein-DNA and protein-protein interactions during chromatin organisation and transcription. The BEN domain-containing protein 3 (BEND3) is shown to interact (via BEN domains 1 and 3) with ERCC6L (via N-terminal TPR repeat and SNF2 HeliC region of ERCC6L) which stimulates the ERCC6L translocase and ATPase activities.
Wikipedia: In molecular biology, BEN domain is a conserved protein domain found in a variety of eukaryotic transcriptional regulators and chromatin-associated proteins. It is named after three proteins in which it was first identified: BANP, E5R, and NAC1. The BEN domain is thought to play a critical role in protein-DNA and protein-protein interactions, particularly in gene silencing, transcriptional regulation, and chromatin organization. It is commonly involved in processes such as development, differentiation, and the maintenance of cellular identity through epigenetic regulation.
Pfam PF17063: Phenol-soluble modulin alpha peptide family (family)
This family includes various Phenol-soluble modulin proteins from S. Aureus.  Psma4 is a methicillin-resistant Staphylococcus aureus (MRSA) protein that may recruit, activate and induce the lysis of human neutrophils.  It stimulates the secretion of IL-8 and also has haemolytic activity during MRSA infection.
Pfam PF16736: Single Cache-like (domain)
This entry represents the N-terminal Cache-like domain of the alkaline phosphatase synthesis sensor protein PhoR. It covers part of the PAS-like fold that share a central five-stranded beta- sheet of identical topology to other PAS domains.
Wikipedia: In molecular biology, the cache domain is an extracellular protein domain that is predicted to have a role in small-molecule recognition in a wide range of proteins, including the animal dihydropyridine-sensitive voltage-gated Ca2+ channel alpha-2delta subunit, and various bacterial chemotaxis receptors. The name Cache comes from CAlcium channels and CHEmotaxis receptors. This domain consists of an N-terminal part with three predicted strands and an alpha-helix, and a C-terminal part with a strand dyad followed by a relatively unstructured region. The N-terminal portion of the (unpermuted) Cache domain contains three predicted strands that could form a sheet analogous to that present in the core of the PAS domain structure. Cache domains are particularly widespread in bacteria such as Vibrio cholerae. The animal calcium channel alpha-2delta subunits might have acquired a part of their extracellular domains from a bacterial source. The Cache domain appears to have arisen from the GAF-PAS fold despite their divergent functions.
Pfam PF25074: Domain of unknown function (DUF7798) (domain)
This domain is found in uncharacterised proteins mainly from plants. It is predicted to fold into an alpha-helical bundle.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF19664: Family of unknown function (DUF6167) (family)
This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 86 and 118 amino acids in length.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF09879: Predicted membrane protein (DUF2106) (family)
This domain, found in various hypothetical archaeal proteins, has no known function.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF24141: EGF-like domain-containing protein ComC LRR domain (repeat)
This entry represents the LRR domain found in N-terminal of EGF-like domain containing protein ComC from amoebas. This protein regulates aggregation, inhibiting lagC and activating lagD expression. The function of this domain is unknown.
Pfam PF15613: Williams-Beuren syndrome DDT (WSD), D-TOX E motif (family)
This family represents the combined alpha-helical module found in diverse eukaryotic chromatin proteins. Based on the Ioc3 structure, the N-terminus of this module is inferred to interact with nucleosomal linker DNA and the SLIDE domain of ISWI proteins. The resulting complex forms a protein ruler that measures out the spacing between two adjacent nucleosomes. The acidic residue from the GxD signature at the N-terminus is a major determinant of the interaction between the ISWI and WHIM motifs. The N-terminal portion also contacts the inter-nucleosomal linker DNA. The module shows a great domain architectural diversity and is often combined with other modified histone peptide recognizing and DNA binding domains, some of which discriminate methylated DNA. The WSD module constitutes the inter-nucleosomal linker DNA binding site in the major groove of DNA, and was first identified as WSD, the D-TOX E motif of plant homeodomains homologous with the mutant transcription factor causing Williams-Beuren syndrome in association with the DDT-domain.
Pfam PF16936: Putative holin (family)
This is a family of putative holins from Actinobacteria with three TM regions.
Pfam PF12974: ABC transporter, phosphonate, periplasmic substrate-binding protein (family)
This is a family of periplasmic proteins which are part of the transport system for alkylphosphonate uptake.
Pfam PF11995: Domain of unknown function (DUF3490) (family)
This presumed domain is functionally uncharacterised. This domain is found in eukaryotes. This domain is about 160 amino acids in length. This domain is found associated with [pfam:PF00225]. This domain is found associated with [pfam:PF00225]. This domain has two conserved sequence motifs: EVE and ESA.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF07699: Tyrosine-protein kinase ephrin type A/B receptor-like (domain)
This family has repeats of a region rich in cysteines. It is found in various ephrin type A and B receptors, which have tyrosine kinase activity.
Pfam PF23821: Family of unknown function (DUF7191) (family)
This family of uncharacterized proteins is found in viruses, primarily cyanophages that infect cyanobacteria such as Synechococcus and Prochlorococcus species. The family contains short sequences, generally between 45-50 amino acid residues in length. No functional information is available for members of this family.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF08586: RSC complex, Rsc14/Ldb7 subunit (family)
RSC is an ATP-dependent chromatin remodelling complex found in yeast. The RSC components Rsc7/Npl6 and Rsc14/Ldb7 interact physically and/or functionally with Rsc3, Rsc30, and Htl1 to form a module important for a broad range of RSC functions.
Pfam PF20239: Family of unknown function (DUF6596) (family)
This presumed domain is found at the C-terminus of bacterial RNA polymerase ECF sigma factor proteins.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF19004: Family of unknown function (DUF5733) (family)
A highly conserved domain of unknown function found in Platyhelminthes.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF07958: Protein of unknown function (DUF1688) (family)
A family of uncharacterised proteins.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF17301: Putative lipoprotein LpqV (family)
This is a family of cell surface proteins found in Mycobacterium with no known function.
Pfam PF07758: Protein of unknown function (DUF1614) (family)
This is a family of sequences coming from hypothetical proteins found in both bacterial and archaeal species.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF04725: Photosystem II 10 kDa polypeptide PsbR (family)
This protein is associated with the oxygen-evolving complex of photosystem II.  Its function in photosynthesis is not known. The C-terminal hydrophobic region functions as a thylakoid transfer signal but is not removed.
Pfam PF05623: Protein of unknown function (DUF789) (family)
This family consists of several plant proteins of unknown function.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF00218: Indole-3-glycerol phosphate synthase (domain)
Indole-3-glycerol phosphate synthase (4.1.1.48) (IGPS) catalyses the fourth step in the biosynthesis of tryptophan, the ring closure of 1-(2-carboxy-phenylamino)-1-deoxyribulose into indol-3-glycerol-phosphate. In some bacteria, IGPS is a single chain enzyme. In others, such as Escherichia coli, it is the N-terminal domain of a bifunctional enzyme that also catalyses N-(5'-phosphoribosyl)anthranilate isomerase (5.3.1.24) (PRAI) activity (see IPR001240), the third step of tryptophan biosynthesis. In fungi, IGPS is the central domain of a trifunctional enzyme that contains a PRAI C-terminal domain and a glutamine amidotransferase (2.4.2) (GATase) N-terminal domain.

A structure of the IGPS domain of the bifunctional enzyme from the mesophilic bacterium E. coli (eIGPS) has been compared with the monomeric indole-3-glycerol phosphate synthase from the hyperthermophilic archaeon Sulfolobus solfataricus (sIGPS). Both are single-domain (Î²/Î±)8 barrel proteins, with one (eIGPS) or two (sIGPS) additional helices inserted before the first Î² strand .
Wikipedia: The enzyme indole-3-glycerol-phosphate synthase (IGPS) (EC 4.1.1.48) catalyzes the chemical reaction1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate  1-C-(indol-3-yl)-glycerol 3-phosphate + CO2 + H2O
Pfam PF19651: Family of unknown function (DUF6154) (family)
This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 80 amino acids in length.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF17744: Family of unknown function (DUF5581) Fn3-like domain (domain)
This is a family of unknown function found in chordates. This entry represents a C-terminal fibronectin type III domain.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF14389: Leucine-zipper of ternary complex factor MIP1 (family)
This leucine-zipper is towards the N-terminus of MIP1 proteins. These proteins, here largely from plants, are subunits of the TORC2 (rictor-mTOR) protein complex controlling cell growth and proliferation. The leucine-zipper is likely to be the region that interacts with plant MADS-box factors,
Pfam PF01807: CHC2 zinc finger (domain)
This domain is principally involved in DNA binding in DNA primases.
Pfam PF02905: Epstein Barr virus nuclear antigen-1, DNA-binding domain (domain)
This domain has a ferredoxin-like fold.
Pfam PF03081: Exo70 exocyst complex subunit C-terminal (repeat)
The Exo70 protein is a subunit of the exocyst complex, first identified in yeast, it is evolutionarily conserved. It mediates the tethering of post-Golgi secretory vesicles to the plasma membrane and promotes the assembly of the SNARE complex for membrane fusion. It also plays a role in cell polarisation, primary ciliogenesis, cytokinesis, pathogen invasion, tumourigenesis and metastasis. It is a member of the the Complex Associated with Tethering Containing Helical Rods (CATCHRs) family which also includes Conserved Oligomeric Golgi complex (COG) and Golgi-Associated Retrograde Protein complex (GARP) and DSL1 complexes, all evolutionarily related and share structural features consisting of alpha-helical bundles at the C-terminus and coiled-coil region at the N-terminus. Exo70 interacts with phospholipids and Rho3 GTPase. This interaction mediates one of the three known functions of Rho3 in cell polarity: vesicle docking and fusion with the plasma membrane (the other two functions are regulation of actin polarity and transport of exocytic vesicle from the mother cell to the bud). This is the C-terminal domain of Exo70, which consists of alpha-helical bundles involved in binding the small GTPase Rho3 and it is important for localization to the plasma membrane as it directly interacts with phosphatidylinositol 4,5-biphosphate The interaction with phospholipids is essential for the membrane association of the exocyst complex.
Wikipedia: Exocyst complex component 7 is a protein that in humans is encoded by the EXOC7 gene. It was formerly known as Exo70.
Pfam PF15119: Apolipoprotein C4 (family)
Apolipoprotein C-IV, also known as apolipoprotein C4, may play a role in lipid metabolism .
Wikipedia: Apolipoprotein C-IV, also known as apolipoprotein C4, is a protein that in humans is encoded by the APOC4 gene.
Pfam PF15683: Testis development-related protein (family)
TDRP is a family of proteins found in chordates. It is predominantly expressed in the testis. distributed in both cytoplasm and the nuclei of spermatogenic cells. It may act as a nuclear factor with an important role in spermatogenesis.
Pfam PF06610: L-alanine exporter (family)
AlaE is a family of Gram-negative amino-acid transporters.  It is not entirely clear why bacteria export metabolites but recent studies have shown that many excrete alanine. AlaE is likely to be the exporter protein for L-alanine. UniProtKB:A8ANM6, UniProt:G4R961 and UniProt:H5SVY7 are classified as putative alanine exporters.
Pfam PF24721: Half a barrel family (family)
This entry represents a region found in proteins possibly related to plasmid partitioning. This domain is composed of two copies of this region each of which forms three strands of a 6-stranded beta barrel.  This entry is named the HAB region for Half A Barrel. The beta barrel is capped at one end by two short beta strands, one from each region and at the other end of the barrel by a pair of longer alpha helices, again one contributed by each subunit.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF13106: Domain of unknown function (DUF3961) (family)
This presumed domain is functionally uncharacterised. This domain family is found in bacteria and viruses, and is approximately 40 amino acids in length.
Pfam PF16601: Rabosyn-5 repeating NPF sequence-motif (disordered)
NPF is a natively unstructured but well-conserved region found in eukaryotic proteins of the Rabenosyn-5 type, wherein the sequence motif arginine-proline-phenylalanine followed by several glutamates and aspartates is repeated up to four times along the sequence. NPF lies between the two Rab-binding domains, for Rab-4 and Rab-5, at the C-terminal end of these proteins. Rabosyn-5 (or rabenosyn) is also involved in cell-polarity determination in developing wing epithelia of Drosophila, when the NPF-motif may be implicated. These NPF motifs create a region of strong positive surface potential which appear to bind Eps15 homology, EH or EF-hand, domains on proteins involved in vesicle trafficking.
Pfam PF07872: Protein of unknown function (DUF1659) (family)
This family consists of hypothetical bacterial proteins of unknown function.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF22010: AKP thiolase subunit OrtA (family)
This entry represents 2-amino-4-ketopentanoate thiolase (also known as AKP thiolase) subunit OrtA. OrtA is a subunit of a PLP-dependent enzyme that catalyses the thiolytic cleavage with coenzyme A (CoA) to form acetyl-CoA and alanine. OrtA is predicted to adopt a beta-barrel structurally similar to the beta-barrel of Tudor/PWWP/MBT superfamily.
Pfam PF08711: TFIIS helical bundle-like domain (domain)
Mediator is a large complex of up to 33 proteins that is conserved from plants to fungi to humans - the number and representation of individual subunits varying with species {1-2]. It is arranged into four different sections, a core, a head, a tail and a kinase-activity part, and the number of subunits within each of these is what varies with species. Overall, Mediator regulates the transcriptional activity of RNA polymerase II but it would appear that each of the four different sections has a slightly different function. Mediator exists in two major forms in human cells: a smaller form that interacts strongly with pol II and activates transcription, and a large form that does not interact strongly with pol II and does not directly activate transcription. Notably, the 'small' and 'large' Mediator complexes differ in their subunit composition: the Med26 subunit preferentially associates with the small, active complex, whereas cdk8, cyclin C, Med12 and Med13 associate with the large Mediator complex. This family includesthe C terminal region of a number of eukaryotic hypothetical proteins which are homologous to the Saccharomyces cerevisiae protein IWS1. IWS1 is known to be an Pol II transcription elongation factor and interacts with Spt6 and Spt5.
Wikipedia: Mediator of RNA polymerase II transcription subunit 26 is an enzyme that in humans is encoded by the MED26 gene. It forms part of the Mediator complex.
Pfam PF15721: Annexin-2 receptor (family)
This family of proteins acts as annexin-2 receptors.
Pfam PF12162: STAT1 TAZ2 binding domain (conserved_site)
This domain family is found in eukaryotes, and is approximately 20 amino acids in length, and the family is found in association with [pfam:PF02865], [pfam:PF00017], [pfam:PF01017], [pfam:PF02864]. This domain is the C terminal domain of STAT1. This domain binds selectively to the TAZ2 domain of CRB (CREB-binding protein). In this process it becomes a transcriptional activator and can initiate transcription of certain genes.
Pfam PF22078: Large ribosomal subunit protein bL9m C-terminal domain (domain)
This entry represents a presumed domain found at the C-terminal of the large ribosomal subunit protein bL9m (mitochondrial) from animals. This domain may adopt a similar fold than prokaryotic large ribosomal subunit protein bL9.