SII-SWORD/CoKE huggingface dataset:
Pfam PF07119: Protein of unknown function (DUF1375) (family)
This family consists of several hypothetical, putative lipoproteins of around 80 residues in length. Members of this family seem to be specific to the Class Gammaproteobacteria. The function of this family is unknown.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF05836: Chorion protein S16 (family)
This family consists of several examples of the fruit fly specific chorion protein S16.  The chorion genes of Drosophila are amplified in response to developmental signals in the follicle cells of the ovary.
Pfam PF08814: XisH protein (domain)
The fdxN element, along with two other DNA elements, is excised from the chromosome during heterocyst differentiation in cyanobacteria. The xisH as well as the xisF and xisI genes are required.
Pfam PF14255: Cysteine-rich CPXCG (family)
This family of proteins is found in bacteria. Proteins in this family are approximately 60 amino acids in length. There are 5 conserved cysteines which occur in a CPXCG motif and a DCXXCCXP motif.
Pfam PF01894: Uncharacterised protein family UPF0047 (family)
This family has no known function. The alignment contains a conserved aspartate and histidine that may be functionally important.
Pfam PF21430: Distal tail protein pb9, B domain (domain)
This entry includes phage distal tail proteins which form a hexameric ring located at the tail tube end, such as pb9 from bacteriophage T5. pb9 consists of two domains, A and B. This entry represents domain B which adopts an OB fold and is inserted in domain A.
Pfam PF20938: DUF2264 C-terminal domain (domain)
This domain is found at the C-terminus of DUF2264 family proteins. This domain adopts a beta sandwich domain that is structurally related to [pfam:PF07940], suggesting that DUF2264 proteins are oligosaccharide degrading enzymes.
Pfam PF16514: putative NADH-ubiquinone oxidoreductase chain E (domain)
This putative NADH-ubiquinone oxidoreductase chain E family is found in Epsilonproteobacteria, chiefly in Helicobacter pylori. All proteins in the family are less than 100 residues in length.
Pfam PF20706: Family 4 Glycosyltransferase in conflict systems (family)
This entry corresponds to Family 4 Glycosyltransferase domain comprised of two Rossmann fold subdomains. The domain is found in architecturally-rich proteins of metazoan counter-invader systems and in bacterial conflict systems.
Pfam PF20624: DMRT5, DMB domain (domain)
This is the DMB domain found at the C-terminal of DMRT5 proteins (doublesex and mab-3 related transcription factor, also known as Doublesex- and mab-3-related transcription factor A2). These proteins are involved in sexual development although not restricted to the developing gonads in vertebrates. DMRT5, together with DMRT4, has been identified as an important regulator of neurogenesis. This domain is adjacent the DMA domain ([pfam:PF03474]), both of which are required for neuronal differentiation.
Pfam PF18256: Co-chaperone HscB tetracysteine metal binding motif (domain)
This is the N-terminal domain of human co-chaperone protein HscB (hHscB). This domain is capable of binding a metal ion through its tetracysteine metal binding motif. The metal atom is coordinated by a set of four cysteine residues (Cys41, Cys44, Cys58 and Cys61) on opposed beta-hairpins. Although the N-domain lacks any recognizable secondary structure elements, it has several distant structural homologs including C-4 zinc finger domains and rubredoxin.
Pfam PF05503: Poxvirus G7-like (family)
This family of proteins which include vaccinia virus G7L and fowlpox virus FPV120 are associated with the intracellualar mature virus particle. The function of this family of proteins is not known.
Pfam PF05231: MASE1 (domain)
Predicted integral membrane sensory domain found in histidine kinases, diguanylate cyclases and other bacterial signaling proteins. This domain has been reported to bind aspartate and participate in protein-protein interactions.
Pfam PF17068: Required for respiratory growth protein 8 mitochondrial (family)
RRG8 is a mitochondrial protein that plays an important role in maintenance of mtDNA due to is required for respiratory activity and maintenance and expression of the mitochondrial genome.
Pfam PF22771: Dermonecrotic toxin, barrel-like domain (domain)
Dermonecrotic toxin (ToxA), also known as Pasteurella multocida toxin (PMT), inhibits osteoblastic differentiation in mammals and birds. It consists of an N-terminal domain that binds to target cells, and a large C-terminal domain. This entry represents a presumed barrel-like domain found between the N- and C-terminal domains.
Pfam PF04954: Siderophore-interacting protein (family)
This entry includes the vibriobactin utilization protein viuB, which is involved in the removal of iron from iron-vibriobactin complexes, as well as several hypothetical proteins.
Pfam PF09297: NADH pyrophosphatase zinc ribbon domain (domain)
This domain is found in between two duplicated NUDIX domains. It has a zinc ribbon structure.
Pfam PF00486: Transcriptional regulatory protein, C terminal (domain)
Bacteria and plants frequently use two-components signal transduction systems (TCSs) to adapt to environmental changes and to survive under stress conditions. Typical TCSs couple a transmembrane histidine protein kinase (HK), which detects changes in the environmnent, to a cytosolic response regulator (RR), which often alters gene expression. Most RRs contain two distinct domains: an N-terminal receiver domain and a C-terminal effector domain. The former autophosphorylates on a histidine residue on detecting an external stimulus. The phosphate is then transferred to an invariant aspartate residue in a highly conserved receiver domain of the response regulator. Phosphorylation activates a variable effector domain of the response regulator, which triggers the cellular response. The C-terminal effector domain contains DNA and RNA polymerase binding sites. Several dimers or monomers bind head to tail to small tandem repeats upstream of the genes. The RNA polymerase binding sites interact with the alpha or sigma subunit of RNA polymerase. The OmpR/PhoB subfamily is the largest subfamily of RRs. Members of the OmpR/PhoB subfamily include such diverse transcriptional regulators as Escherichia coli PhoB (of the phosphate assimilation pathway), Enterococcus faecium VanR (which controls resistance to the antibiotic vancomycin), and Agrobacterium tumefaciens VirG (involved in the establishment of crown gall tumors in plant. The C-terminal effector domain of the OmpR/PhoB subfamily RRs binds DNA. This DNA-binding domain is also found in proteins other than response regulators, such as Vibrio cholerea ToxR, a transmembrane protein involved in cholera toxin expression .

The OmpR/PhoB-type DNA-binding domain has the typical fold of the winged helix-turn-helix DNA-binding domain. The structure of the OmpR/PhoB-type DNA- binding domain consists of three Î±-helices packed against two antiparallel Î²-sheets, an N-terminal four-stranded antiparallel Î²-sheet and a C- terminal hairpin. The hairpin interacts with a short stretch of Î²-strand, that connects helices Î±1 and Î±2, to generate a three- stranded antiparallel Î²-sheet. The topology for the domain is Î²1-Î²2- Î²3-Î²4-Î±1-Î²5-Î±2-Î±3-Î²6-Î²7. The hydrophobic core of the domain is formed by sidechains contributed by each of the seven Î²-strands and three Î±-helices .
Pfam PF22124: Glycosyl hydrolase family 95 catalytic domain (repeat)
The founding member of the GH95 family of glycosyl hydrolases is alpha-1,2-fucosidase that catalyses the hydrolysis of an alpha-1,2-linked fucose. A member of this family, FucOB from A. muciniphila was shown to hydrolyse all three types of H antigen structures to obtain the afucosylated Bombay phenotype. Members of this family are multidomain proteins and contain a central catalytic domain with an (alpha/alpha)6 helical barrel topology, represented by this entry.
Pfam PF19906: C-glycoside deglycosidase beta subunit (domain)
This is the structural domain of C-glycoside deglycosidase beta subunit (CGDB, also known as CarC), a carbon-carbon bond-cleaving enzyme which participates in the metabolism of C-glycosides. It acts on the C6-glycosylated compounds 3''-dehydroisovitexin (3''-oxo-isovitexin) and 3''-dehydroisoorientin (3''-oxo-homoorientin). In some members, this domain is found in combination with other domains.
Pfam PF04202: Foot protein 3 (family)
Mytilus foot protein-3 (Mfp-3) is a highly polymorphic protein family located in the byssal adhesive plaques of blue mussels.
Pfam PF12962: Protein of unknown function (DUF3851) (family)
A family of uncharacterised proteins found by clustering human gut metagenomic sequences.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF24142: EGF-like domain-containing protein ComC first beta-sandwich (domain)
This entry represents the first beta-sandwich domain found in EGF-like domain containing protein ComC from amoebas. This protein regulates aggregation, inhibiting lagC and activating lagD expression. The function of this domain is unknown.
Pfam PF24769: At2g29880 C-terminal domain (domain)
This domain is found C-terminal in Uncharacterized protein At2g29880 from Arabidopsis thaliana and related plant proteins. Some proteins containing this domain have also a Myb/SANT-like domain at the N terminus. The function of this domain is unknown.
Pfam PF10313: Uncharacterised protein domain (DUF2415) (repeat)
This is a short, 30 residue domain, from a family of proteins conserved in fungi. The function is unknown. There is a characteristic DLL sequence motif.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF12634: Inheritance of peroxisomes protein 1 (family)
Inp1 is a family of peripheral membrane proteins of peroxisomes. Inp1p binds Pex25p, Pex30p, and Vps1p, all of which are involved in controlling peroxisome division. The levels of Inp1p vary with the cell cycle, and Inp1 acts as a factor that retains peroxisomes in cells and controls peroxisome division. Inp1p promotes the retention of peroxisomes in mother cells and buds of budding yeast by attaching peroxisomes to as-yet-unidentified cortical structures.
Pfam PF06421: GTP-binding protein LepA C-terminus (family)
This family consists of the C-terminal region of several pro- and eukaryotic GTP-binding LepA proteins.
Pfam PF03188: Eukaryotic cytochrome b561 (family)
Cytochrome b561 is a secretory vesicle-specific electron transport protein. It is an integral membrane protein, that binds two heme groups non-covalently.  This is a eukaryotic family. Members of the 'prokaryotic cytochrome b561' family can be found in Pfam: PF01292.
Wikipedia: Cytochrome b561 is an integral membrane protein responsible for electron transport, binding two heme groups non-covalently. It is a family of ascorbate-dependent oxidoreductase enzymes.
Pfam PF21497: Conjugal transfer protein-like, C-terminal domain (domain)
This domain is found at the C-terminal end of Conjugal transfer protein from Clostridium perfringens (TcpC) and similar proteins predominantly found in enterobacteria. TcpC is essential for efficient conjugative transfer. Its structure is similar to this of TraM from Enterococcus and the conjugative type IV secretion systems (T4SS) VirB8 proteins from Agrobacterium tumefaciens. The region represented in this entry contains two NTF2-like domains separated by a seven-amino acid linker.
Pfam PF00891: O-methyltransferase domain (domain)
This family includes a range of O-methyltransferases. These enzymes utilise S-adenosyl methionine.
Pfam PF01369: Sec7 domain (domain)
The Sec7 domain is a guanine-nucleotide-exchange-factor (GEF) for the [pfam:PF00025] family.
Pfam PF17502: Family of unknown function (DUF5434) (family)
This is a family of unknown function found in Varicellovirus.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF24626: Tf2-1-like, SH3 domain (domain)
This domain is found towards the C-terminal end of Transposon Tf2-1 polyprotein from Schizosaccharomyces pombe (Tf2-1), a retrotransposon that belong to the gypsy-like elements.
Pfam PF15204: Kita-kyushu lung cancer antigen 1 (family)
This is a family of cancer antigens.
Pfam PF20612: SHOCT domain (domain)
This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and viruses. Proteins in this family are typically between 53 and 72 amino acids in length. This family of proteins is related to the SHOCT domain.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF22137: T6SS, Phospholipase effector Tle1-like, C-terminal domain (domain)
This domain is found in the type VI secretion system (T6SS) Phospholipase effector Tle1 from Pseudomonas aeruginosa ([swissprot:Q9HYV3]), which hydrolyse membrane phospholipids. Tle1 is organised into two distinct parts, the phospholipase catalytic module ([pfam:PF09994]) and the putative membrane-anchoring module (this entry), that can be divided into three independent domains: a three-helix bundle, a six-helix bundle and an alpha/beta mixed fold with a two-layer sandwich structure.
Pfam PF00684: DnaJ central domain (domain)
The central cysteine-rich (CR) domain of DnaJ proteins contains four repeats of the motif CXXCXGXG where X is any amino acid. The isolated cysteine rich domain folds in zinc dependent fashion. Each set of two repeats binds one unit of zinc. Although this domain has been implicated in substrate binding, no evidence of specific interaction between the isolated DNAJ cysteine rich domain and various hydrophobic peptides has been found.
Wikipedia: In molecular biology, chaperone DnaJ, also known as Hsp40, is a molecular chaperone protein. It is expressed in a wide variety of organisms from bacteria to humans.
Pfam PF10935: Protein of unknown function (DUF2637) (family)
This family of proteins has no known function.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF06953: Arsenical resistance operon protein ArsD (domain)
ArsD was initially reported to be a trans-acting repressor of the  arsRDABC operon, which confers resistance to arsenicals and antimonials in Escherichia coli. It has since been shown to be a metallochaperone that delivers As(III) to ArsA (the catalytic  subunit of the ArsAB pump encoded by arsRDABC), increasing its  affinity for As(III) allowing resistance to environmental  concentrations of arsenic. ArsD has three conserved cysteines Cys(12), Cys(13), and Cys(18), which form a three sulfur-coordinated  As(III) binding site that is essential for delivery of As(III) to,  and activation of the ArsAB pump. This family also includes  ArsD homologues which do not contain the conserved CCxxxxC required  for function.
Wikipedia: In molecular biology, the ars operon is an operon found in several bacterial taxon. It is required for the detoxification of arsenate, arsenite, and antimonite. This system transports arsenite and antimonite out of the cell. The pump is composed of two polypeptides, the products of the arsA and arsB genes. This two-subunit enzyme produces resistance to arsenite and antimonite. Arsenate, however, must first be reduced to arsenite before it is extruded. A third gene, arsC, expands the substrate specificity to allow for arsenate pumping and resistance. ArsC is an approximately 150-residue arsenate reductase that uses reduced glutathione (GSH) to convert arsenate to arsenite with a redox active cysteine residue in the active site. ArsC forms an active quaternary complex with GSH, arsenate, and glutaredoxin 1 (Grx1). The three ligands must be present simultaneously for reduction to occur.
Pfam PF16028: Solute carrier family 3 member 2 N-terminus (family)
This domain is found at the N-terminus of solute carrier family 3 member 2 proteins (4F2 cell-surface antigen heavy chain).
Wikipedia: 4F2 cell-surface antigen heavy chain is a protein that in humans is encoded by the SLC3A2 gene.
Pfam PF06820: Putative prophage tail fibre C-terminus (family)
This family represents the C-terminus of a prophage tail fibre protein found mostly in E. coli. All family members contain a conserved RLGP motif.
Pfam PF24789: SAC9 second GBDL domain (domain)
This domain is found toward the C terminus of the  SAC9 from Arabidopsis thaliana which is a probable phosphoinositide phosphatase that is involved in modulating phosphoinositide signals during the stress response. SAC9 contains three domains (GBDL) with topology similar to the galactose binding domains (GBD), in particular to the anaphase promoting complex subunit 10. These domains are located in the second half of the proteins. The domain represented by this entry is the second of the the three. It is predicted to contain a large insertion (~40 residues long) before the last beta-strand.
Pfam PF24185: Domain of unknown function (DUF7413) (domain)
This entry represents a small family of uncharacterised phage proteins. Structure prediction suggests these proteins are composed of a three stranded beta sheet packed against a pair of alpha helices.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF19869: Family of unknown function (DUF6342) (family)
This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0001877) is described by MIBiG as an example of the following biosynthetic class, polyketide, in particular the  cyphomycin biosynthetic gene cluster from Streptomyces sp. ISID311.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF06187: Protein of unknown function (DUF993) (domain)
This family consists of several hypothetical bacterial proteins of unknown function.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF07034: Origin recognition complex (ORC) subunit 3 N-terminus (domain)
This family represents the N-terminus (approximately 300 residues) of subunit 3 of the eukaryotic origin recognition complex (ORC). Origin recognition complex (ORC) is composed of six subunits that are essential for cell viability. They collectively bind to the autonomously replicating sequence (ARS) in a sequence-specific manner and lead to the chromatin loading of other replication factors that are essential for initiation of DNA replication. This domain is predicted to contain an AAA+ fold but lack the residues important for ATP hydrolysis, thus, it is called AAA+ like.
Wikipedia: Origin recognition complex subunit 3 is a protein that in humans is encoded by the ORC3 (ORC3L) gene.
Pfam PF07790: Archaeal Type IV pilin, N-terminal (family)
This entry represents the N-terminal domain of archaeal  pilins, which play important roles in surface adhesion. Sequences covered by this domain are not mixed up with sequences having such an extremely high sequence conservation as described in.
Pfam PF05729: NACHT domain (domain)
This NTPase domain is found in apoptosis proteins as well as those involved in MHC transcription activation. This family is closely related to [pfam:PF00931].
Wikipedia: The NACHT domain is an evolutionarily conserved protein domain. This NTPase domain is found in apoptosis proteins as well as those involved in MHC transcription. Its name reflects some of the proteins that contain it: NAIP, CIITA, HET-E and TEP1.
Pfam PF19763: Domain of unknown function (DUF6250) (domain)
This domain is found in bacterial proteins which are functionally uncharacterised. Proteins in this family are typically between 225 and 1025 amino acids in length. There is a conserved Tryptophan residue at the N-terminal and a highly conserved SDLN sequence.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF23089: ELAPOR1-like, C-terminal domain (domain)
This domain is found at the C-terminal of Endosome/lysosome- associated apoptosis and autophagy regulator family member 2 from humans (ELAPOR1), which may protect cells from cell death by inducing cytosolic vacuolisation and up-regulating the autophagy pathway and may play a role in apoptosis and cell proliferation. It is predicted to adopt a predominantly beta structure.