SII-SWORD/CoKE huggingface dataset:
Pfam PF10866: Protein of unknown function (DUF2704) (family)
This viral family of proteins has no known function.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF00350: Dynamin family (domain)
This entry represents the N-terminal domain found in dynamins.
Membrane transport between compartments in eukaryotic cells requires proteins that allow the budding and scission of nascent cargo vesicles from one compartment and their targeting and fusion with another. Dynamins are large GTPases that belong to a protein superfamily  that, in eukaryotic cells, includes classical dynamins, dynamin-like proteins, OPA1, Mx proteins, mitofusins and guanylate-binding proteins/atlastins , and are involved in the scission of a wide range of vesicles and organelles. They play a role in many processes including budding of transport vesicles, division of organelles, cytokinesis and pathogen resistance.

The minimal distinguishing architectural features that are common to all dynamins and are distinct from other GTPases are the structure of the large GTPase domain (300 amino acids) and the presence of two additional domains; the middle domain and the GTPase effector domain (GED), which are involved in oligomerization and regulation of the GTPase activity.
Wikipedia: Dynamin is a GTPase protein responsible for endocytosis in the eukaryotic cell. Dynamin is part of the "dynamin superfamily", which includes classical dynamins, dynamin-like proteins, Mx proteins, OPA1, mitofusins, and GBPs. Members of the dynamin family are principally involved in the scission of newly formed vesicles from the membrane of one cellular compartment and their targeting to, and fusion with, another compartment, both at the cell surface as well as at the Golgi apparatus. Dynamin family members also play a role in many processes including division of organelles, cytokinesis and microbial pathogen resistance.
Pfam PF22886: Domain of unknown function (DUF7021) (domain)
This entry represents a beta barrel domain which is found associated with [pfam:PF10020].
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF05894: Podovirus DNA encapsidation protein (Gp16) (family)
This family consists of several DNA encapsidation protein (Gp16) sequences from the phi-29-like viruses. Gene product 16 catalyses the in vivo and in vitro genome-encapsidation reaction.
Pfam PF21669: Shieldin complex subunit 2, first OB fold domain (domain)
This entry represents the first OB fold domain found in the middle of Shieldin complex subunit 2 (SHLD2, formerly known as FAM35A). SHLD2 is a component of the shieldin complex, which plays an important role in repair of DNA double-stranded breaks (DSBs).
Pfam PF24947: Phosphoglucomutase-1, C-terminal domain (domain)
This entry represents the C-terminal domain of phosphoglucomutase-1 (PGM1) from human, and its homologues from vertebrates and fungi, which catalyses the bi-directional interconversion between alpha-D-glucose 1-phosphate (G1P) and alpha-D-glucose 6-phosphate (G6P), a reaction that is essential for normal carbohydrate metabolism and is also important in the cytoplasmic biosynthesis of nucleotide sugars needed for glycan biosynthesis. This domain contains a six-stranded antiparallel beta-sheet with two alpha-helices lying on the face of the sheet opposite the active site which is located centrally, in a deep cleft between the four domains of these proteins. This domain contains the phosphate-binding loop which interacts with the substrate phosphate moiety.
Pfam PF14101: Domain of unknown function (DUF4275) (family)
This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 140 amino acids in length.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF23779: Bacteriophage Baseplate Tube Protein Family (family)
The Baseplate tube protein family is involved in the assembly of the simplified baseplate structure of bacteriophages. Members of this family, such as Baseplate tube protein p140, interact with other proteins including the p132 collar protein ring and components of the cone, namely DTP-pb9 and BHP-pb3, to form a crucial part of the phage's baseplate. This structure is essential for the phage to attach to and penetrate the host bacterial cell wall during infection.
Pfam PF15162: Protein SPO16 homolog (family)
This entry represents the Protein SPO16 homolog (SPO16, also known as Synaptonemal complex reinforcing element SCRE), including the mammalian orthologue of budding yeast Spo16. It plays a key role in reinforcing the integrity of the central element of the synaptonemal complex (SC), resulting in the SC stabilization which ensures the progression of meiotic prophase I in male and female germ cells [1. It promotes homologous recombination and crossing-over in meiotic prophase I via its association with SHOC1. It is also required for the localization of TEX11 and MSH4 to recombination intermediates.
Pfam PF21901: TMEM87A/B, GOLD domain (domain)
This entry represents the GOLD (Golgi-dynamics) domain of TMEM87A and TMEM87B. Members of this entry are evolutionary related to GPR107 and GPR108. Together with GPR180, TMEM145, TMEM181 and WLS, they have been described as GOST proteins (for GOLD domain seven-transmembrane helix proteins) given they share the same domain architecture consisting of a GOLD domain atop of a membrane-spanning seven-transmembrane helix domain. TMEM87s localise to the Golgi and have suggested roles in protein trafficking to and from the Golgi. TMEM87 has been proposed to act as mechanosensitive ion channels, however, structural and functional analysis suggest that they do not act as ion channels or G-protein coupled receptors.
Pfam PF14827: Double sensory domain of two-component sensor kinase (domain)
Cache_3 is the periplasmic sensor domains of sensor histidine kinase of E. coli DcuS. This domain forms one of the components of the two-component signalling system that allows bacteria to adapt to changing environments. The ability of bacteria to monitor and adapt to their environment is crucial to their survival, and two-component signal transduction systems mediate most of these adaptive responses. One component is a histidine kinase sensor - this domain - most commonly part of a homodimeric transmembrane sensor protein, and the second component is a cytoplasmic response regulator. The two components interact in tandem through a phospho-transfer cascade.
Pfam PF23504: YodE (family)
This protein family includes Protein YodE from Escherichia coli, a 48-residues micropeptide encoded by a small open reading frame (smORF) that overlaps on the same strand with small regulatory RNA RyeG. Proteins 50 or fewer residues-long have been shown to regulate the functions of larger proteins in a variety of organisms.
Pfam PF17115: N-terminal domain of toast_rack, DUF2154 (repeat)
This short domain lies at the N-terminus of DUF2154, [pfam:PF09922], hereafter named Toast_rack from its structural resemblance. The function of both domains is unknown though DUF2154 is proposed to be a cell-adhesion protein.
Pfam PF12840: Helix-turn-helix domain (domain)
This domain represents a DNA-binding Helix-turn-helix domain found in transcriptional regulatory proteins.
Wikipedia: Helix-turn-helix is a DNA-binding domain (DBD). The helix-turn-helix (HTH) is a major structural motif capable of binding DNA. Each monomer incorporates two α helices, joined by a short strand of amino acids, that bind to the major groove of DNA. The HTH motif occurs in many proteins that regulate gene expression. It should not be confused with the helix–loop–helix motif.
Pfam PF18434: Kazal-type serine protease inhibitor domain (domain)
Kazal domain found in factor I-like modules (FIMs) region on the carboxyl-terminal of complement component C7 proteins. Complement component C7 is a subunit of the membrane attack complex (MAC), a fundamental machinery in the mammalian innate immunity.  KAZAL domains are common in serine protease inhibitors.
Wikipedia: The Kazal domain  is an evolutionary conserved protein domain usually indicative of serine protease inhibitors. However, kazal-like domains are also seen in the extracellular part of agrins, which are not known to be protease inhibitors.
Pfam PF14017: Protein of unknown function (DUF4233) (family)
This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 122 and 147 amino acids in length. Proteins in this family are integral membrane proteins.
Pfam PF17131: Outer membrane lipoprotein-sorting protein (domain)
This is likely to be a family of outer-membrane lipoprotein-sorting proteins.
Pfam PF18602: Rap1a immunity proteins (domain)
The structures of the immunity proteins, Rap1a , responsible for the inhibition and neutralization of Ssp1 endopeptidase, revealed two distinct folds. The structure of the Ssp1-Rap1a complex revealed a tightly bound heteromeric assembly with two effector molecules flanking a Rap1a dimer. The Rap1a subunit displays a compact globular structure constructed from five alpha-helices that assemble to form the highly stable symmetric dimer.
Pfam PF09640: Domain of unknown function (DUF2027) (domain)
This protein domain is of unknown function. though putatively involved in DNA mismatch repair. It is associated with [pfam:PF01713].
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF01470: Pyroglutamyl peptidase (domain)
This group of cysteine peptidases belong to MEROPS peptidase family C15 (pyroglutamyl peptidase I, clan CF). The type example being pyroglutamyl peptidase I of Bacillus amyloliquefaciens. There are similarities in structure between members of clan CF and members of three clans of metallopeptidases (MC, MF and MH) and all four are included in the same superfamily (phosphorylase/hydrolase-like fold) by the SCOP database. Members of clan CF have an Î±/Î²/Î± sandwich fold .

Pyroglutamyl peptidase I (also known as pyrrolidone carboxyl peptidase, Pcp or PYRase) is an exopeptidase that hydrolytically removes the pGlu from pGlu-peptides or pGlu-proteins . PYRase has been found in prokaryotes and eukaryotes where at least two different classes have been characterised: the first containing bacterial and animal type I PYRases, and the second containing animal type II and serum PYRases. Type I and bacterial PYRases are soluble enzymes, while type II PYRases are membrane-bound. The primary application of PYRase has been its utilisation for protein or peptide sequencing, and bacterial diagnosis . The conserved residues Cys-144 and His-168 have been identified by inhibition and mutagenesis studies .
Pyroglutamyl-peptidase 1-like protein belongs to the petidase C15 family, though its exact function is not known.
Pfam PF21162: ETF-QO, ubiquinone-binding (domain)
Electron transfer flavoprotein-ubiquinone oxidoreductase (ETF-QO) is a a 4Fe4S flavoprotein located in the inner mitochondrial membrane and catalyses ubiquinone (UQ) reduction. It forms a single structural domain with three functional regions (that bind FAD, the 4Fe4S cluster, and UQ) which are closely packed and share structural elements. This domain includes the residues involved in UQ binding. This domain is also found in FixC proteins from bacteria, which share similarities with ETF-QO.
Pfam PF05616: Neisseria meningitidis TspB protein (family)
This family consists of several Neisseria meningitidis TspB virulence factor proteins.
Pfam PF05412: Equine arterivirus Nsp2-type cysteine proteinase (family)
Corresponds to Merops family C33. These peptidases are involved in viral polyprotein processing in replication.
Pfam PF19381: Family of unknown function (DUF5956) (family)
This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0001073) is described by MIBiG as an example of the following biosynthetic classes, NRP (non-ribosomal peptide) and polyketide.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF05580: SpoIVB peptidase S55 (family)
The protein SpoIVB plays a key role in signalling in the final sigma-K checkpoint of Bacillus subtilis.
Pfam PF21331: Isoamylase, C-terminal (domain)
Isoamylase from Pseudomonas amyloderamosa hydrolyses alpha-1,6-glucosidic linkages of amylopectin and glycogen. It consists of three domains: the N-terminal ([pfam:PF02922]), the catalytic domain ([pfam:PF00128]) and the C-terminal all-beta domain, presented in this entry.
Pfam PF03771: Domain of unknown function (DUF317) (domain)
This a sequence family found in a set of bacterial proteins with no known function. This domain is currently only found in streptomyces bacteria.                 Most proteins contain two copies of this domain.
Pfam PF22176: AF_0587-like, pre-PUA domain (domain)
This domain is found in AF_0587 from Archaeoglobus fulgidus. It is found N-terminal to the PUA domain ([pfam:PF01472]).
Pfam PF06964: Alpha-L-arabinofuranosidase C-terminal domain (domain)
This family represents the C-terminus (approximately 200 residues) of bacterial and eukaryotic alpha-L-arabinofuranosidase ([ec:3.2.1.55]). This catalyses the hydrolysis of nonreducing terminal alpha-L-arabinofuranosidic linkages in L-arabinose-containing polysaccharides.
Pfam PF16829: Avirulence protein ATR13, RxLR effector (family)
ATR13 is expressed by the plant pathogen oomycete Hyaloperonospora. Such phytopathogenic oomycetes like the one that infects Arabidopsis, Hyaloperonospora arabidopsidis (Hpa), grow intercellularly, forming parasitic structures called haustoria. Haustoria play a role in feeding and suppression of host defence systems. A whole range of pathogen proteins, called effectors, are secreted across this haustorial membrane, a subset of which are further translocated across the plant plasma membrane by an unknown mechanism that is present in both plants and animals.  ATR13 is an RxLR effector from the downy mildew oomycete, and is a very dynamic protein. It contains two surface-exposed patches of polymorphism, one of which is involved in the specific recognition by host R-genes. The R-gene-products detect the presence of the infection by recognising the effector proteins. Once detected, the host R-genes trigger apoptosis of the host cell. The R-gene-products carry a specific motif, RxLR, that is recognises the effector proteins.
Pfam PF07133: Merozoite surface protein (SPAM) (family)
This family consists of several Plasmodium falciparum SPAM (secreted polymorphic antigen associated with merozoites) proteins. Variation among SPAM alleles is the result of deletions and amino acid substitutions in non-repetitive sequences within and flanking the alanine heptad-repeat domain. Heptad repeats in which the a and d position contain hydrophobic residues generate amphipathic alpha-helices which give rise to helical bundles or coiled-coil structures in proteins. SPAM is an example of a P. falciparum antigen in which a repetitive sequence has features characteristic of a well-defined structural element.
Pfam PF13513: HEAT-like repeat (repeat)
The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see [pfam:PF00514]). These EZ repeats are found in subunits of cyanobacterial phycocyanin lyase and other proteins and probably carry out a scaffolding role.
Wikipedia: A HEAT repeat is a protein tandem repeat structural motif composed of two alpha helices linked by a short loop. HEAT repeats can form alpha solenoids, a type of solenoid protein domain found in a number of cytoplasmic proteins. The name "HEAT" is an acronym for four proteins in which this repeat structure is found: Huntingtin, elongation factor 3 (EF3), protein phosphatase 2A (PP2A), and the yeast kinase TOR1. HEAT repeats form extended superhelical structures which are often involved in intracellular transport; they are structurally related to armadillo repeats. The nuclear transport protein importin beta contains 19 HEAT repeats.
Pfam PF15903: Filopodia upregulated, FAM65 (family)
PL48 is associated with cytotrophoblast and lineage-specific HL-60 cell differentiation. The N-terminal part of the family is found to induce the formation of filopodia. It is found in vertebrates.
Pfam PF16369: C-terminal lipocalin-like domain (domain)
This is the C-terminal domain of Glycosyl hydrolases family 43. It is around 100 residues in length from various Bacteroides species. The function of this family is unknown. The domain is distantly related to lipocalins.
Pfam PF07794: Protein of unknown function (DUF1633) (family)
This family contains sequences derived from a group of hypothetical proteins expressed  by Arabidopsis thaliana. These sequences are  highly similar and the region concerned is  about 100 residues long.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF23479: Apicomplexa microprotein (family)
This protein family includes uncharacterised microproteins encoded by small open reading frames (smORFs) from apicomplexa, including [swissprot:A7AMA3] from the parasite Babesia bovis.
Pfam PF12393: Dr family adhesin (family)
This domain family is found in bacteria, and is approximately 20 amino acids in length. The family is found in association with [pfam:PF04619]. This family is the Dr-family adhesin expressed by uropathogenic E. coli.
Pfam PF19929: Family of unknown function (DUF6392) (family)
This family of proteins is functionally uncharacterised and it is predominantly found in Proteobacteria. Proteins in this family are typically between 55 and 170 amino acids in length. Proteins in this family are likely to be related to pyocin immunity protein.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF05283: Multi-glycosylated core protein 24 (MGC-24), sialomucin (family)
This family consists of several MGC-24 (or Cd164 antigen) proteins from eukaryotic organisms.  MGC-24/CD164 is a sialomucin expressed in many normal and cancerous tissues. In humans, soluble and transmembrane forms of MGC-24 are produced by alternative splicing.
Pfam PF22458: Methyltr_RsmF/B-like, ferredoxin-like domain (domain)
This entry represents a ferredoxin-like domain found in methyltransferases RsmB, RsmF and related sequences.
Pfam PF17437: Family of unknown function (DUF5416) (family)
This is a family of unknown function found in Campylobacteria.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF24761: ASCIZ forth C2H2 zinc finger domain (domain)
This domain is found in the human ATM interactor (also known as ATM/ATR-substrate CHK2-interacting zinc finger protein (ASCIZ)) and related proteins from animals. These proteins are transcription factors that are essential for cell survival and the formation of RAD51 foci, a response to methylating DNA damage. They are also involved in the regulation of ATM (ataxia telangiectasia mutated) kinase activity, particularly in the absence of DNA damage, potentially by stabilising ATM. ASCIZ is predicted to contain four zinc finger domains. This entry represents the forth zinc finger domain.
Pfam PF22685: Gal80p, C-terminal domain (domain)
This domain is found in the homologues of Gal80p, an yeast regulatory protein closely related to glucose-fructose oxidoreductase. In Gal80p, this domain is likely involved in the binding of Gal4p.
Pfam PF10291: Muniscin C-terminal mu homology domain (domain)
The muniscins are a family of endocytic adaptors that is conserved from yeast to humans.This C-terminal domain is structurally similar to mu homology domains, and is the region of the muniscin proteins involved in the interactions with the endocytic adaptor-scaffold proteins Ede1-eps15. This interaction influences muniscin localisation. The muniscins provide a combined adaptor-membrane-tubulation activity that is important for regulating endocytosis.
Pfam PF14951: Domain of unknown function (DUF4503) (family)
This family of proteins is found in eukaryotes. Proteins in this family are typically between 313 and 876 amino acids in length.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF23720: Family of unknown function (DUF7161) (family)
This protein family includes a group of uncharacterised short sequences from actinobacteria. Many members are annotated as UbiD family decarboxylases. They are predicted to adopt an all beta configuration.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.