SII-SWORD/CoKE huggingface dataset:
Pfam PF05974: Domain of unknown function (DUF892) (domain)
This protein family is found in bacteria, including Protein YciF from Escherichia coli. This protein is produced by bacteria in response to stress conditions. It adopts a dimeric configuration in which each monomer shows five alpha-helices. Its function is still unknown.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF16180: RelB leucine zipper (domain)
This domain is a leucine zipper found in RelB transcription factors.
Pfam PF10745: Protein of unknown function (DUF2530) (family)
This family of proteins with unknown function appears to be restricted to mycobacteria.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF02408: CUB-like domain (domain)
This is a family of hypothetical C. elegans proteins.  The aligned region has no known function nor do any of the proteins which possess it. However, this domain is related to the CUB domain.
Wikipedia: CUB domain  is an evolutionarily conserved protein domain. The CUB domain is a structural motif of approximately 110 residues found almost exclusively in extracellular and plasma membrane-associated proteins, many of which are developmentally regulated. These proteins are involved in a diverse range of functions, including complement activation, developmental patterning, tissue repair, axon guidance and angiogenesis, cell signalling, fertilisation, haemostasis, inflammation, neurotransmission, receptor-mediated endocytosis, and tumour suppression. Many CUB-containing proteins are peptidases belonging to MEROPS peptidase families M12A (astacin) and S1A (chymotrypsin).
Pfam PF23853: Family of unknown function (DUF7216) (family)
This entry represents a family of cyanophage proteins, including Gp130, that are found in a variety of Synechococcus and Prochlorococcus phages.  The family members are typically around 100 amino acids in length. Structure predictions do not show a globular fold for this protein. The exact function of this family is unknown.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF12986: Domain of unknown function (DUF3870) (family)
A family based on the C-terminal domain of 3KOG which shows structural similarity to pore-forming proteins, suggesting it may have a lytic function.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF17238: NUP160, helical domain (domain)
This entry represents a helical domain that can be found in NUP160, also known as SAR1, a nucleoporin protein in Arabidopsis thaliana. It is a member of the NUP107-160 nuclear pore sub-complex. NUP160 plays a role in normal auxin signalling, which works in synergy with ethylene to control various ethylene-dependent phenomena. Also, it contributes to pathogen defense, nucleocytoplasmic mRNA export, and is required for disease resistance.
Pfam PF18896: Lysozyme like domain (domain)
This entry represents a lysozyme like domain found in candidate phyla radiation bacteria. The domain contains several conserved cysteine and histidine residues suggesting that it may bind to zinc.
Pfam PF12652: CotJB protein (domain)
CotJ is a sigma E-controlled operon involved in the spore coat of Bacillus subtilis. This protein has been identified as a spore coat protein.
Pfam PF23591: Cartilage intermediate layer protein 1-like domain (domain)
This domain is found in human Cartilage intermediate layer protein 1 (CILP) and similar animal proteins. CILP is thought to play a role in cartilage scaffolding. This domain is predicted to show a 7 stranded beta sandwich fold. It is often found C-terminal to [pfam:PF13927].
Pfam PF15859: Deleted in esophageal cancer 1 family (family)
DEC1 is a family of proteins found in primates. The protein has been identified as being deleted in oesophageal cancers so is also referred to as candidate tumour suppressor CTS9.  Proteins in this family are approximately 70 amino acids in length.
Pfam PF04204: Homoserine O-succinyltransferase (family)
The activation of homoserine through succinylation of homoserine in some bacteria, such as Escherichia coli and Bacillus cereus, is carried out by homoserine O-succinyltransferase (HTS, [ec:2.3.1.46]), while other bacteria, such as Haemophilus influenzae, Pseudomonas aeruginosa, and Mycobacterium tuberculosis, acetylate homoserine via homoserine O-acetyltransferase (HTA;[ec:2.3.1.31]). This family also includes serine acetyltransferase CysE ([ec:2.3.1.30]) from Lactobacillus casei, which catalyses the formation of O-acetyl serine from L-serine and acetyl-CoA, and is involved in cysteine biosynthesis.
Pfam PF11943: Protein of unknown function (DUF3460) (family)
This family of proteins are functionally uncharacterised. This protein is found in bacteria. Proteins in this family are about 70 amino acids in length. This protein has a conserved WDK sequence motif.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF11706: CGNR zinc finger (domain)
This family consists of a C-terminal zinc finger domain. It seems likely to be DNA-binding given the conservation of many positively charged residues. The domain is named after a highly conserved motif found in many members of the family.
Pfam PF09826: Beta propeller domain (repeat)
Members of this family comprise secreted bacterial proteins containing C-terminal beta-propeller domain distantly related to WD-40 repeats. Jpred secondary-structure prediction shows family to be a series of 4 short beta-strands, characteristic of beta-propeller families.
Pfam PF24792: Domain of unknown function (DUF7701) (domain)
This domain is found in uncharacterised proteins mainly from bacteria. It is predicted to adopt an alpha-helical structure with a highly conserved DVHDxWxxW sequence motif which may constitute a ligand binding site. This domain is likely to form a homodimer. Investigation of STRING networks suggests this protein may functionally interact with [pfam:PF24838] a likely octameric membrane complex.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF07082: Protein of unknown function (DUF1350) (family)
This family consists of several hypothetical proteins from both cyanobacteria and plants. Members of this family are typically around 250 residues in length. The function of this family is unknown but the species distribution indicates that the family may be involved in photosynthesis.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF00378: Enoyl-CoA hydratase/isomerase (domain)
This family contains a diverse set of enzymes including: enoyl-CoA hydratase, napthoate synthase, carnitate racemase, 3-hydroxybutyryl-CoA dehydratase and dodecanoyl-CoA delta-isomerase.
Wikipedia: The crotonase family comprises mechanistically diverse proteins that share a conserved trimeric quaternary structure, the core of which consists of 4 turns of a (beta/beta/alpha)n superhelix.
Pfam PF21126: Katanin p60 subunit A1, MIT domain (domain)
Katanin is an ATP-dependent microtubule severing protein composed of 60kDa (katanin-p60) and 80kDa (katanin-p80) subunits (KATNA1 and KATNB1, respectively). In mammals, there are two additional A-like subunits (KATNAL1 and KATNAL2) and one additional B-like subunit (KATNBL1). KATNA1 has the enzymatic activity for microtubule severing and plays a key role in cytoskeletal reorganisation, while KATNB is the regulatory subunit. Formation of the katanin A/B heterodimer is mediated by the N-terminal Microtubule Interacting and Trafficking domain (MIT, represented in this entry) of KATNA1/KATNAL1) and a conserved C-terminal domain of KATNB. This domain is organised in an antiparallel three-helix bundle.
Pfam PF06728: GPI transamidase subunit PIG-U (family)
Many eukaryotic proteins are anchored to the cell surface via glycosylphosphatidylinositol (GPI), which is posttranslationally attached to the carboxyl-terminus by GPI transamidase. The mammalian GPI transamidase is a complex of at least four subunits, GPI8, GAA1, PIG-S, and PIG-T. PIG-U is thought to represent a fifth subunit in this complex and may be involved in the recognition of either the GPI attachment signal or the lipid portion of GPI.
Pfam PF05218: Protein of unknown function (DUF713) (family)
This family contains several proteins of unknown function from C.elegans. The GO annotation suggests that this protein is involved in nematode development and has a positive regulation on growth rate.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF07565: Band 3 cytoplasmic domain (domain)
This family contains the cytoplasmic domain of the Band 3 anion exchange proteins that exchange Cl-/HCO3-. Band 3 constitutes the most abundant polypeptide in the red blood cell membrane, comprising 25% of the total membrane protein. The cytoplasmic domain of band 3 functions primarily as an anchoring site for other membrane-associated proteins. Included among the protein ligands of cdb3 are ankyrin, protein 4.2, protein 4.1, glyceraldehyde-3-phosphate dehydrogenase (GAPDH), phosphofructokinase, aldolase, hemoglobin, hemichromes, and the protein tyrosine kinase (p72syk).
Wikipedia: The anion exchanger family is a member of the large APC superfamily of secondary carriers. Members of the AE family are generally responsible for the transport of anions across cellular barriers, although their functions may vary. All of them exchange bicarbonate. Characterized protein members of the AE family are found in plants, animals, insects and yeast. Uncharacterized AE homologues may be present in bacteria. Animal AE proteins consist of homodimeric complexes of integral membrane proteins that vary in size from about 900 amino acyl residues to about 1250 residues. Their N-terminal hydrophilic domains may interact with cytoskeletal proteins and therefore play a cell structural role. Some of the currently characterized members of the AE family can be found in the Transporter Classification Database.
Pfam PF01545: Cation efflux family (family)
Members of this family are integral membrane proteins, that are found to increase tolerance to divalent metal ions such as cadmium, zinc, and cobalt. These proteins are thought to be efflux pumps that remove these ions from cells.
Wikipedia: Cation diffusion facilitators (CDFs) are transmembrane proteins that provide tolerance of cells to divalent metal ions, such as cadmium, zinc, and cobalt. These proteins are considered to be efflux pumps that remove these divalent metal ions from cells. However, some members of the CDF superfamily are implicated in ion uptake. All members of the CDF family possess six putative transmembrane spanners with strongest conservation in the four N-terminal spanners. The Cation Diffusion Facilitator (CDF) Superfamily includes the following families:1.A.52 - The Ca2+ Release-activated Ca2+ (CRAC) Channel (CRAC-C) Family
2.A.4 - The Cation Diffusion Facilitator (CDF) Family
2.A.19 - The Ca2+:Cation Antiporter (CaCA) Family
2.A.103 - The Bacterial Murein Precursor Exporter (MPE) Family
Pfam PF03130: PBS lyase HEAT-like repeat (repeat)
This family contains a short bi-helical repeat that is related to [pfam:PF02985]. Cyanobacteria and red algae harvest light energy using macromolecular complexes known as phycobilisomes (PBS), peripherally attached to the photosynthetic membrane. The major components of PBS are the phycobiliproteins. These heterodimeric proteins are covalently attached to phycobilins: open-chain tetrapyrrole chromophores, which function as the photosynthetic light-harvesting pigments. Phycobiliproteins differ in sequence and in the nature and number of attached phycobilins to each of their subunits. This family includes the lyase enzymes that specifically attach particular phycobilins to apophycobiliprotein subunits. The most comprehensively studied of these is the CpcE/F lyase [swissprot:P31967] [swissprot:P31968], which attaches phycocyanobilin (PCB) to the alpha subunit of apophycocyanin. Similarly, MpeU/V attaches phycoerythrobilin to phycoerythrin II, while CpeY/Z is thought to be involved in phycoerythrobilin (PEB) attachment to phycoerythrin (PE) I (PEs I and II differ in sequence and in the number of attached molecules of PEB: PE I has five, PE II has six). All the reactions of the above lyases involve an apoprotein cysteine SH addition to a terminal delta 3,3'-double bond.  Such a reaction is not possible in the case of phycoviolobilin (PVB), the phycobilin of alpha-phycoerythrocyanin (alpha-PEC). It is thought that in this case, PCB, not PVB, is first added to apo-alpha-PEC, and is then isomerised to PVB. The addition reaction has been shown to occur in the presence of either of the components of alpha-PEC-PVB lyase PecE or PecF (or both). The isomerisation reaction occurs only when both PecE and PecF components are present, i.e. the PecE/F phycobiliprotein lyase is also a phycobilin isomerase. Another member of this family is the NblB protein [swissprot:Q9Z3G5], whose similarity to the phycobiliprotein lyases was previously noted.  This constitutively expressed protein is not known to have any lyase activity. It is thought to be involved in the coordination of PBS degradation with environmental nutrient limitation. It has been suggested that the similarity of NblB to the phycobiliprotein lyases is due to the ability to bind tetrapyrrole phycobilins via the common repeated motif.
Pfam PF03865: Haemolysin secretion/activation protein ShlB/FhaC/HecB (family)
This family represents a group of sequences that are related to ShlB from Serratia marcescens. ShlB is an outer membrane protein pore involved in the Type Vb or Two-partner secretion system where it is functions to secrete and activate the haemolysin ShlA. The activation of ShlA occurs during secretion when ShlB imposes a conformational change in the inactive haemolysin to form the active protein.
Pfam PF09746: Tumour-associated protein (family)
Membralin is evolutionarily highly conserved; though it seems to represent a unique protein family. The protein appears to contain several transmembrane regions. In humans it is expressed in certain cancers, particularly ovarian cancers. Membralin-like gene homologues have been identified in plants including grape, cotton and tomato.
Pfam PF08011: PD-(D/E)XK nuclease superfamily (family)
This family contains many hypothetical bacterial proteins.  It has been identified as a member of the PD-(D/E)XK nuclease superfamily through transitive meta profile searches. DUF1703 has the predicted secondary structure pattern of the restriction endonuclease-like fold core and contains an additional beta-strand at the C-terminus.
Pfam PF03461: TRCF domain (domain)
The transcription-repair coupling factor (TRCF, product of the mfd gene) couples transcription and DNA repair in bacteria. TRCF removes transcription elongation complexes stalled at DNA lesions and recruits the nucleotide excision repair (NER) machinery to the site. This protein, comprised of eight domains, including region of structurally similar to UvrB, shows to distinct activities: the relief of transcription-dependent inhibition of nucleotide excision repair (NER) by recognition and ATP-dependent removal of a stalled RNAP covering the damaged DNA; and the stimulation of DNA repair by recruitment of the Uvr(A)BC endonuclease. The C-terminal region of TRCF have been shown to be necessary for RNAP displacement .
Pfam PF18793: Nitrous oxide reductase propeller repeat 2 (repeat)
Nitrous oxide reductases usually contain a seven-bladed beta-propeller domain with external short alpha-helices. This entry represents a single blade of the propeller, without alpha- helical insertion.
Pfam PF24512: Domain of unknown function (DUF7592) (domain)
This is a domain found in uncharacterised sequences from Caenorhabditis spp. In SwissProt:O45754, it represents the second domain. It may adopt a CUB-like fold.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF18016: SAM domain (Sterile alpha motif) (domain)
SAM domains are found in a diverse set of proteins, which include scaffolding proteins, transcription regulators, translational regulators tyrosine kinases and serine/threonine kinases. Structures of SAM domains reveal a common five helical structure. The SAM domain is involved in a variety of functions. The most widespread function is in domain-domain interactions. This SAM (sterile alpha motif) domain is found in epidermal growth factor receptor kinase substrate (EPS8) and other proteins.
Wikipedia: In molecular biology, the protein domain Sterile alpha motif is a putative protein interaction module present in a wide variety of proteins involved in many biological processes. The SAM domain that spreads over around 70 residues is found in diverse eukaryotic organisms. SAM domains have been shown to homo- and hetero-oligomerise, forming multiple self-association architectures and also binding to various non-SAM domain-containing proteins, nevertheless with a low affinity constant.
Pfam PF19673: Family of unknown function (DUF6176) (family)
This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0000198) is described by MIBiG as an example of the following biosynthetic classes, polyketide and saccharide. It  includes a member from the arenimycin A biosynthetic gene cluster  from Salinispora arenicola CNB527.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF23418: Domain of unknown function (DUF7108) (domain)
This domain is found at the N-terminal end of the uncharacterised protein HVO_0731 from Haloferax volcanii ([swissprot:D4GTA0]) and similar proteins from halobacteria. It has several conserved motifs RLTR/KLxR and LVxHPxEW. It is predicted to adopt an alpha-beta structure. The function of this domain is unknown.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF18968: Family of unknown function (DUF5707) (family)
The function of DUF5707 is not clear.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF12668: Protein of unknown function (DUF3791) (family)
This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 71 and 125 amino acids in length.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF07883: Cupin domain (domain)
This family represents the conserved barrel domain of the 'cupin' superfamily ('cupa' is the Latin term for a small barrel).
Wikipedia: The cupin superfamily is a diverse superfamily of proteins named after its conserved barrel domain. The superfamily includes a wide variety of enzymes as well as non-enzymatic seed storage proteins.
Pfam PF16207: RAWUL domain RING finger- and WD40-associated ubiquitin-like (domain)
The RAWUL domain is found at the C-terminus of poly-comb group RING finger proteins.  It is a ubiquitin-like domain.  RAWUL binds directly to PUFD, a domain on BCOR proteins (BCL6 corepressor).  BCOR has emerged as an important player in development and health.
Pfam PF03258: Baculovirus FP protein (coiled_coil)
The FP protein is missing in baculovirus (Few Polyhedra) mutants.
Pfam PF17874: MalT-like TPR region (repeat)
This entry contains a series of TPR repeats.