SII-SWORD/CoKE huggingface dataset:
Pfam PF06680: Protein of unknown function (DUF1181) (family)
This family consists of several hypothetical proteins of around 120 residues in length which are found specifically in Trypanosoma brucei. The function of this family is unknown.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF15054: Domain of unknown function (DUF4535) (family)
This family includes the uncharacterised protein C7orf73 that is found in eukaryotes. Members are generally less than 100 residues in length. Although the precise function of the domain is still unknown, members have a predicted N-terminal signal peptide sequence which suggests they are short secreted peptides.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF21198: Set1/Ash2 histone methyltransferase complex subunit ASH2-like, WH (domain)
This domain is found in Set1/Ash2 histone methyltransferase complex subunit ASH2 from humans (ASH2L, named after 'Absent, small, homeotic disks-2-like') and similar animal proteins. ASH2L is a non-catalytic component of the Set1/Ash2 histone methyltransferase (HMT) complex. Aberrant expression and recurrent recurrent mutations in components of this complex have been related to different diseases. This entry represents the winged-helix (WH) domain, which is found N-terminal to the SPRY domain ([pfam:PF00622]) in ASH2L. It binds directly to DNA and shows a compact alpha/beta structure consisting of three alpha-helices and a curved three-stranded beta-sheet.
Pfam PF20170: Plexin cytoplasmic RhoGTPase-binding domain (domain)
This entry represents the RhoGTPase-binding domain found in the cytoplasmic domain of plexins.
Pfam PF19256: LAIKA domain (domain)
This presumed domain is found exclusively in the CCAR1 protein.
Pfam PF04777: Erv1 / Alr family (family)
Biogenesis of Fe/S clusters involves a number of essential mitochondrial  proteins. Erv1p of Saccharomyces cerevisiae mitochondria is  required for the maturation of Fe/S proteins in the cytosol. The ALR  (augmenter of liver regeneration) represents a mammalian orthologue of yeast Erv1p. Both Erv1p and full-length ALR are located in the  mitochondrial intermembrane an d it thought to operate downstream of  the mitochondrial ABC transporter.
Pfam PF22062: DNA polymerase alpha subunit B, OB domain (domain)
This entry represents the OB domain of DNA polymerase alpha subunit B. B subunits of DNA polymerases stabilize the catalytic subunit, play a role in regulation of the DNA synthesis in a cell cycle-dependent manner and act as scaffolds mediating interactions with other components of the replication machinery.
Pfam PF11414: Adenomatous polyposis coli tumour suppressor protein (family)
The tumour suppressor protein, APC, has a nuclear export activity as well as many different intracellular functions. The structure consists of three alpha-helices forming two separate antiparallel coiled coils.
Pfam PF16744: KIAA1045 RING finger (domain)
This entry represents a zinc finger domain found in the uncharacterised protein from animals KIAA1045.
Pfam PF08018: Frog antimicrobial peptide (family)
This family includes antimicrobial peptides secreted from skins of frogs. The secretion of antimicrobial peptides from the skins of frogs plays an important role in the self defense of these frogs. Structural characterization of these peptides showed that they belonged to four known families: the brevinin-1 family, the esculentin-2 family, the ranatuerin-2 family and the temporin family.
Pfam PF14299: Phloem protein 2 (family)
Phloem protein 2 (PP2) is one of the most abundant and enigmatic proteins in the phloem sap. PP2 is translocated in the assimilate stream where its lectin activity or RNA-binding properties can exert effects over long distances.
Pfam PF01776: Ribosomal L22e protein family (family)
This entry represents the large ribosomal subunit protein eL22 family.
Ribosomal protein eL22 forms part of the 60S ribosomal subunit  found in eukaryotes. Rattus norvegicus (Rat) eL22 is related to ribosomal proteins from other eukaryotes and is identical in amino acid sequence to human EAP, the EBER 1 (Epstein-Barr virus (strain GD1) (HHV-4) (Human herpesvirus 4) encoded RNA) associated protein .
Ribosomes are the particles that catalyse mRNA-directed protein synthesis in all organisms. The codons of the mRNA are exposed on the ribosome to allow tRNA binding. This leads to the incorporation of amino acids into the growing polypeptide chain in accordance with the genetic information. Incoming amino acid monomers enter the ribosomal A site in the form of aminoacyl-tRNAs complexed with elongation factor Tu (EF-Tu) and GTP. The growing polypeptide chain, situated in the P site as peptidyl-tRNA, is then transferred to aminoacyl-tRNA and the new peptidyl-tRNA, extended by one residue, is translocated to the P site with the aid the elongation factor G (EF-G) and GTP as the deacylated tRNA is released from the ribosome through one or more exit sites . About 2/3 of the mass of the ribosome consists of RNA and 1/3 of protein. The proteins are named in accordance with the subunit of the ribosome which they belong to the small (S1 to S31) and the large (L1 to L44). Usually they decorate the rRNA cores of the subunits.

Many ribosomal proteins, particularly those of the large subunit, are composed of a globular, surfaced-exposed domain with long finger-like projections that extend into the rRNA core to stabilise its structure. Most of the proteins interact with multiple RNA elements, often from different domains. In the large subunit, about 1/3 of the 23S rRNA nucleotides are at least in van der Waal's contact with protein, and L22 interacts with all six domains of the 23S rRNA. Proteins S4 and S7, which initiate assembly of the 16S rRNA, are located at junctions of five and four RNA helices, respectively. In this way proteins serve to organise and stabilise the rRNA tertiary structure. While the crucial activities of decoding and peptide transfer are RNA based, proteins play an active role in functions that may have evolved to streamline the process of protein synthesis. In addition to their function in the ribosome, many ribosomal proteins have some function 'outside' the ribosome .
Pfam PF22026: Alpha-amylase C-terminal domain (domain)
This is the C-terminal domain of alpha-amylase and related enzymes. This domain follows the catalytic beta/alpha domain. It folds into a beta-sandwich with a greek key topology.
Pfam PF10082: Putative beta-barrel porin 2 (family)
This domain is a putative beta-barrel porin type 2.
Wikipedia: Porins are beta barrel proteins that cross a cellular membrane and act as a pore, through which molecules can diffuse. Unlike other membrane transport proteins, porins are large enough to allow passive diffusion, i.e., they act as channels that are specific to different types of molecules. They are present in the outer membrane of gram-negative bacteria and some gram-positive mycobacteria, the outer membrane of mitochondria, and the outer chloroplast membrane.
Pfam PF14920: MDM2-binding (family)
MTBP, or MDM2-binding protein, binds to MDM2. The MDM2 protein, through its interaction with p53, plays an important role in the regulation of the G1 checkpoint of the cell cycle. MTBP promotes MDM2-mediated ubiquitination and degradation of p53 and also MDM2 stabilisation in an MDM2 RING finger-dependent manner. MTBP differentially regulates the E3 ubiquitin ligase activity of MDM2 towards two of its most critical targets (itself and p53) and in doing so significantly contributes to MDM2-dependent p53 homeostasis in unstressed cells. MTBP inhibits cancer cell migration by interacting with a protein involved in cell motility. This motility protein is alpha-actinin-4 (ACTN4). It is unclear which regions of MTBP interact with which binding-partner.  See PF14918, PF14919.
Pfam PF24231: Family of unknown function (DUF7444) (family)
This entry represents a conserved family found in various bacteriophages, particularly those infecting Escherichia, Klebsiella, and other Enterobacteriaceae. The function of this domain is currently unknown. This family is commonly found in phages belonging to the Drexlerviridae family, including genera such as Webervirus, Tempevirinae, and Tunavirinae. This entry shows some structurally similar features to [pfam:PF24227].
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF23215: Leucine-rich repeat and WD repeat-containing protein 1, WD domain (repeat)
This entry represents the WD (beta-propeller) domain found at the C-terminal of Leucine-rich repeat and WD repeat-containing protein 1 (LRWD1) from animals and related sequences. LRWD1 (also known as CENP-33 and ORCA) is required for for G1/S transition. It recruits and stabilizes the origin recognition complex (ORC) onto chromatin during G1 to establish pre-replication complex (preRC) and to heterochromatic sites in pre-replicated cells. This proteins consist of a LRR domain at the N-terminal and a WD domain at the C-terminal. This domain is required for chromatin association of LRWD1 and for its binding to ORC.
Pfam PF02978: Signal peptide binding domain (domain)
The signal recognition particle (SRP) is a multimeric protein, which along with its conjugate receptor (SR), is involved in targeting secretory proteins to the rough endoplasmic reticulum (RER) membrane in eukaryotes, or to the plasma membrane in prokaryotes . SRP recognises the signal sequence of the nascent polypeptide on the ribosome. In eukaryotes this retards its elongation until SRP docks the ribosome-polypeptide complex to the RER membrane via the SR receptor . Eukaryotic SRP consists of six polypeptides (SRP9, SRP14, SRP19, SRP54, SRP68 and SRP72) and a single 300 nucleotide 7S RNA molecule. The RNA component catalyses the interaction of SRP with its SR receptor . In higher eukaryotes, the SRP complex consists of the Alu domain and the S domain linked by the SRP RNA. The Alu domain consists of a heterodimer of SRP9 and SRP14 bound to the 5' and 3' terminal sequences of SRP RNA. This domain is necessary for retarding the elongation of the nascent polypeptide chain, which gives SRP time to dock the ribosome-polypeptide complex to the RER membrane. In archaea, the SRP complex contains 7S RNA like its eukaryotic counterpart, yet only includes two of the six protein subunits found in the eukaryotic complex: SRP19 and SRP54 .
This entry represents the M domain of the 54kDa SRP54 component, a GTP-binding protein that interacts with the signal sequence when it emerges from the ribosome. SRP54 of the signal recognition particle has a three-domain structure: an N-terminal helical bundle domain, a GTPase domain, and the M-domain that binds the 7s RNA and also binds the signal sequence. The extreme C-terminal region is glycine-rich and lower in complexity and poorly conserved between species.

This group of proteins include human SRP54 ; Escherichia coli and Bacillus subtilis Ffh protein (Fifty-four homologue), which seems to be the prokaryotic counterpart of SRP54 ; the PilA protein from Neisseria gonorrhoeae, the homologue of FtsY  and archaeal SRP54.
Pfam PF06511: Type III secretion systems tip complex components (family)
This family consists of several invasion plasmid antigen IpaD proteins found in Shigella as well as homologues such as SipD from Salmonella and BipD from Burkholderia. Gram-negative bacteria use type III secretion systems (T3SSs) as protein transport devices for injecting virulence effector proteins into eukaryotic cells during infection. T3SSs consist of a needle complex (NC) and a tip complex (TC). In Shigella the TC is composed of two proteins, each essential to host cell sensing: IpaD and IpaB. IpaD is hydrophilic and required for tip recruitment of the hydrophobic proteins IpaB and IpaC, which later form the pore in host cell membranes.
Pfam PF17156: Gammaproteobacterial periplasmic sensor domain (family)
GAPES2 (GAmmaproteobacterial PEriplasmic Sensor) domain is a periplasmic sensor domain found in diguanylate cyclases, including the diguanylate cyclase DgcI (YliF) of Escherichia coli. It contains three conserved Cys residues that might participate in thiol-disulfide exchange.
Pfam PF00317: Ribonucleotide reductase, all-alpha domain (domain)
Ribonucleotide reductase (RNR, 1.17.4.1)  catalyses the reductive synthesis of deoxyribonucleotides from their corresponding ribonucleotides. It provides the precursors necessary for DNA synthesis. RNRs divide into three classes on the basis of their metallocofactor usage. Class I RNRs, found in eukaryotes, bacteria, bacteriophage and viruses, use a diiron-tyrosyl radical, Class II RNRs, found in bacteria, bacteriophage, algae and archaea, use coenzyme B12 (adenosylcobalamin, AdoCbl). Class III RNRs, found in anaerobic bacteria and bacteriophage, use an FeS cluster and S-adenosylmethionine to generate a glycyl radical. Many organisms have more than one class of RNR present in their genomes.

Ribonucleotide reductase is an oligomeric enzyme composed of a large subunit (700 to 1000 residues) and a small subunit (300 to 400 residues) - class II RNRs are less complex, using the small molecule B12 in place of the small chain .

The reduction of ribonucleotides to deoxyribonucleotides involves the transfer of free radicals, the function of each metallocofactor is to generate an active site thiyl radical. This thiyl radical then initiates the nucleotide reduction process by hydrogen atom abstraction from the ribonucleotide . The radical-based reaction involves five cysteines: two of these are located at adjacent anti-parallel strands in a new type of ten-stranded Î±/Î²-barrel; two others reside at the carboxyl end in a flexible arm; and the fifth, in a loop in the centre of the barrel, is positioned to initiate the radical reaction . There are several regions of similarity in the sequence of the large chain of prokaryotes, eukaryotes and viruses spread across 3 domains: an N-terminal domain common to the mammalian and bacterial enzymes; a C-terminal domain common to the mammalian and viral ribonucleotide reductases; and a central domain common to all three .
Wikipedia: Ribonucleotide reductase (RNR), also known as ribonucleoside diphosphate reductase, is an enzyme that catalyzes the formation of deoxyribonucleotides from ribonucleotides. It catalyzes this formation by removing the 2'-hydroxyl group of the ribose ring of nucleoside diphosphates. This reduction produces deoxyribonucleotides. Deoxyribonucleotides in turn are used in the synthesis of DNA. The reaction catalyzed by RNR is strictly conserved in all living organisms. Furthermore, RNR plays a critical role in regulating the total rate of DNA synthesis so that DNA to cell mass is maintained at a constant ratio during cell division and DNA repair. A somewhat unusual feature of the RNR enzyme is that it catalyzes a reaction that proceeds via a free radical mechanism of action. The substrates for RNR are ADP, GDP, CDP and UDP. dTDP is synthesized by another enzyme from dTMP.
Pfam PF12683: Protein of unknown function (DUF3798) (family)
This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 247 and 417 amino acids in length. Most of the proteins in this family have an N-terminal lipoprotein attachment site. These proteins have distant similarity to periplasmic ligand binding families such as [pfam:PF02608], which suggests that this family have a similar role.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF19491: Family of unknown function (DUF6026) (family)
This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0001285) is described by MIBiG as an example of the following biosynthetic class, other (unspecified). This family  includes a protein from the pseudopyronine A biosynthetic gene  cluster from Pseudomonas putida and appears to be predominantly  found in Pseudomonas.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF16186: Atypical Arm repeat (repeat)
This atypical Arm repeat appears at the very C-terminus of eukaryotic proteins such as importin subunit alpha-2, as the last of the repeating units.
Pfam PF18653: Arcadin 1 (domain)
Arcadin-1 is encoded by arcade gene cluster which also encodes cernactin.  Crenactin is a filament-forming protein from the crenarchaeon Pyrobaculum calidifontis which shows exceptional similarity to eukaryotic F-actin. Arcadin-1 on the other hand does not seem to be related to any known eukaryotic actin binding proteins nor does it affect crenactin polymerisation.
Pfam PF22175: 8-oxoguanine DNA glycosylase (domain)
This entry represents 8-oxoguanine DNA glycosylases (Ogg) that are responsible for the recognition and excision of one of the most common DNA oxidative product, 7,8-dihydro-8-oxoguanine (8-oxoG). These enzymes share a common all-alpha architecture build around a central HhH motif.
Pfam PF01758: Sodium Bile acid symporter family (family)
This family consists of Na+/bile acid co-transporters. These transmembrane proteins function in the liver in the uptake of bile acids from portal blood plasma a process mediated by the co-transport of Na+. Also in the family is ARC3 from S. cerevisiae [swissprot:Q06598] this is a putative transmembrane protein involved in resistance to arsenic compounds.
Wikipedia: This family of proteins are found both in prokaryotes and eukaryotes. In mammals, they are transmembrane proteins with functions in the liver and in the intestine. They are members of the solute carrier family of cotransporter genes which include SLC10A1 and SLC10A2.
Pfam PF23247: Plant disease resistance protein RPS2-like, leucine-rich repeats (repeat)
This entry represents a region of leucine-rich repeats found in Disease resistance protein RPS2 from Arabidopsis thaliana and similar proteins predominantly from plants. RPS2 specifically recognises the AvrRpt2 type III effector avirulence protein from Pseudomonas syringae.
Pfam PF12570: Protein of unknown function (DUF3750) (family)
This family of proteins is found in bacteria. Proteins in this family are typically between 175 and 265 amino acids in length.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF14120: YhzD-like protein (family)
The YhzD-like protein family includes the B. subtilis YhzD protein [swissprot:C0H3Y1] which is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 60 amino acids in length. There is a conserved GKL sequence motif.
Pfam PF12027: Protein of unknown function (DUF3514) (family)
This family of proteins is functionally uncharacterised. This protein is found in bacteria. Proteins in this family are typically between 368 to 823 amino acids in length.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF22659: YycE-like C-terminal domain (domain)
This entry represents a VOC-like domain found at the C-terminal of a group of uncharacterised bacterial sequences, such YycE from Bacillus subtilis.
Pfam PF03066: Nucleoplasmin/nucleophosmin domain (domain)
Nucleoplasmins are also known as chromatin decondensation proteins.  They bind to core histones and transfer DNA to them in a reaction that requires ATP.  This is thought to play a role in the assembly of regular nucleosomal arrays.
Pfam PF12182: Bacterial lipoprotein (domain)
This domain family is found in bacteria, and is approximately 60 amino acids in length. There is a single completely conserved Y residue that may be functionally important. This domain is from a bacterial lipoprotein, a major virulence factor in Gram negative bacteria.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF23611: C2H2 zinc finger (domain)
This entry represents C2H2 zinc finger domains found in multiple copies in a number of transcriptional regulators such as BCL11A, CTCF, ZNF142. BCL11A is involved in the regulation of the developmental switch from gamma- to beta-globin. CTCF acts as atranscriptional activator and also as a repressor of the MYC gene.
Pfam PF23127: DotM, C-terminal cytoplasmic domain (domain)
This entry represent the C-terminal cytoplasmic domain of DotM from Legionella pneumophila and related proteins found mainly in gammaproteobacteria. DotM is a component of Type 4B secretion (T4BS) system that translocates over 300 effectors into the host cell during infection. The DotM cytoplasmic domain adopts an alpha-helical structure consisting of 13 alpha-helices. In the membrane-embedded T4 coupling complex (T4CC), DotM makes extensive contacts with DotL and also interacts with the DotN and DotZ proteins. The DotLMNYZ components form a hetero-pentameric core of the T4CC complex from which the flexible IcmSW module protrudes. These hetero-pentameric complexes assemble and form an inner membrane channel for effectors to pass through.