SII-SWORD/CoKE huggingface dataset:
Pfam PF22858: Domain of unknown function (DUF7016) (domain)
This entry represents a pair of OB fold domains found in a group of uncharacterised proteins from bacteria which have a [pfam:PF22707] domain at the C-terminal.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF12309: KIF-1 binding protein C terminal (family)
This family of proteins is found in bacteria and eukaryotes. Proteins in this family are typically between 365 and 621 amino acids in length. There is a conserved LLP sequence motif. KBP is a binding partner for KIF1Balpha that is a regulator of its transport function and thus represents a type of kinesin interacting protein.
Pfam PF21168: Chorismatase FkbO/Hyg5-like, N-terminal (domain)
This domain is found in the N-terminal region of Chorismatase from (FkbO) and 3-hydroxybenzoate synthase (Hyg5) from Streptomyces hygroscopicus and in similar bacterial proteins. These enzymes catalyse the hydrolysis of chorismate into pyruvate and (dihydro)benzoic acid derivatives and are involved in the biosynthetic pathways forming polyketidic immunosuppressants such as ascomycin (FK520) and tacrolimus (FK506), which prevent T-cell proliferation through initial binding to the immunophilin FKBP12. FkbO is organised into three domains: N-terminal, central and C-terminal. This entry represents the N-terminal and central domains of FkbO, which show two beta-sheets and three alpha-helices. This fold is also found in Hyg5, which employ a fundamentally different reaction mechanism than the typical hydrolysis seen in FkbO.
Pfam PF08891: YfcL protein (domain)
This family of proteins are functionally uncharacterised. THey are related to the short YfcL protein from E. coli.
Pfam PF24144: Phage tudor domain (domain)
This entry represents a small family of uncharacterised phage proteins that are structurally similar to tudor domains. Structure prediction suggests these proteins form a dimer arrangement.
Pfam PF21684: Secreted effector protein PipB2, N-terminal domain (domain)
This domain is found at the N-terminal end of Secreted effector protein PipB2 from Salmonella typhimurium, which is involved in the reorganisation of late endosome/lysosome compartments in host mammalian cells. It is required for virulence. This domain a two-layer alpha-beta structure.
Pfam PF11141: Protein of unknown function (DUF2914) (family)
This bacterial family of proteins has no known function.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF06818: Fez1 (coiled_coil)
This family represents the eukaryotic Fez1 protein. Fez1 contains a leucine-zipper region with similarity to the DNA-binding domain of the cAMP-responsive activating-transcription factor 5. There is evidence that Fez1 inhibits cancer cell growth through regulation of mitosis, and that its alterations result in abnormal cell growth. Note that some family members contain more than one copy of this region.
Pfam PF00692: dUTPase (domain)
dUTPase hydrolyses dUTP to dUMP and pyrophosphate.
Wikipedia: In Enzymology, a dUTP diphosphatase (EC 3.6.1.23) is an enzyme that catalyzes the chemical reactiondUTP + H2O  dUMP + diphosphate
Pfam PF13312: Domain of unknown function (DUF4081) (family)
This domain is often found N-terminal to the GNAT acetyltransferase domain, [pfam:PF00583] and FR47, [pfam:PF08445].
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF06327: Adenylate cyclase, conserved domain (family)
Adenylate cyclase (AC) enzyme uses ATP as its substrate to produce Cyclic AMP (cAMP), a ubiquitous signalling molecule that mediates many cellular processes by activating cAMP- dependent kinases and also inducing protein-protein interactions. Mammalian adenylate cyclase has nine closely related membrane-bound isoforms (AC1-9) showing significant sequence homology and sharing the same overall structure: two hydrophobic transmembrane domains, and two cytoplasmic domains that are responsible for the catalytic activity. These isoforms differ in both their tissue specificity and their regulation. This entry represents a region of unknown function found in many of these isoforms. It is part of the N-terminal cytoplasmic domain but its presence is not necessary for catalytic activity.
Pfam PF23581: Domain of unknown function (DUF7135) (domain)
This domain of unknown function is found N-terminal in a group of uncharacterised proteins mainly from plants. This domain is predicted to adopt a beta-barrel with topology typical for PH domains. It has a weak sequence similarity to Dcp1 PH domain.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF23107: Two consecutive Zinc fingers C2H2 type, ZNF451 (domain)
This entry represents a domain consisting of two consecutive zinc fingers (of the C2H2 type), whose 4 beta-strands are arranged antiparallelly in a beta-sheet. This domain is found in the C-terminal of ZNF451 proteins. E3 SUMO-protein ligase ZNF451 is a key enzyme involved in the sumoylation process, exhibiting a preference for SUMO2 and SUMO3 over SUMO1. It facilitates the UBE2I/UBC9-mediated sumoylation of target proteins, particularly in response to DNA damage and proteasome inhibitors. ZNF451 is essential for MCM4 sumoylation,  and it negatively regulates transcriptional activation mediated by the SMAD4 complex in the context of TGF-beta signaling. Additionally, it inhibits EP300-mediated acetylation of histone H3 at 'Lys-9'.
Pfam PF12565: Protein of unknown function (DUF3747) (family)
This family of proteins is found in bacteria. Proteins in this family are typically between 215 and 413 amino acids in length. There is a conserved DSNGYS sequence motif.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF19923: Family of unknown function (DUF6386) (family)
This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0001796) is described by MIBiG as an example of the following biosynthetic class, NRP (non-ribosomal peptide), in  particular the tauramamide biosynthetic gene cluster from  Brevibacillus laterosporus DSM 25.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF19389: Family of unknown function (DUF5964) (family)
This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0000523) is described by MIBiG as an example of the following biosynthetic class, RiPP (ribosomally synthesised and post-translationally modified peptide).
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF07626: Protein of unknown function (DUF1587) (family)
A region of similarity shared by several Rhodopirellula baltica cytochrome-like proteins that are predicted to be secreted. These proteins also match [pfam:PF07624].
Pfam PF05627: Cleavage site for pathogenic type III effector avirulence factor Avr (domain)
This domain is conserved in small families of otherwise unrelated proteins in both mono-cots and di-cots, suggesting that it has a conserved, plant-specific function. It is found both in the plant RIN4 (resistance R membrane-bound host-target protein) where it appears to contribute to the binding of the protein to both RCS (AvrRpt2 auto-cleavage site) and AvrB, the virulence factor from the infecting bacterium. The cleavage site for the AvrRpt2 avirulence protein would appear to be the sequence motifs VPQFGDW and LPKFGEW, both of which are highly conserved within the domain.
Pfam PF07494: Two component regulator propeller (repeat)
A large group of two component regulator proteins appear to have the same N-terminal structure of  14 tandem repeats. These repeats show homology to [pfam:PF01011] and [pfam:PF00400] indicating that they are likely to form a beta-propeller. This family has been built with artificially high cut-offs in order to avoid overlaps with other beta-propeller  families. The fourteen repeats are likely to form two propellers; it is not clear if these structures are likely to recruit other proteins or interact with DNA.
Pfam PF17043: Mating type protein 1-1-2 of unknown function (family)
MAT1-1-2 is a family of proteins present in Sordariomycetes. They are encoded by the MAT1-1-2 gene which is present in the mating types of Sordariomycetes. The most famous representative if this family is Neurospora crassa. MAT1-1-2 is the generic nomenclature of all mating-type genes encoding proteins with HPG (also termed PPF) domain. This gene and its domain was first identified in Podospora anserina (its name in this species is SMR1) and Neurospora crassa (its name in this species is mat A-2) by Debuchy et al (1993).  HPG was the first name proposed for the domain found in MAT1-1-2 proteins see, based on the most conserved residues (histidine, proline and glycine). PPF was a second denomination proposed by Kanematsu et al (2007) for the same domain but these authors identified different conserved residues (proline, proline and phenylalanine). The function of this domain is not yet known.
Pfam PF19204: Family of unknown function (DUF5876) (family)
This is a family of uncharacterised proteins of unknown function predominantly found in Iridoviridae.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF16120: Domain of unknown function (DUF4836) (family)
This family consists of several uncharacterized proteins around 520 residues in length and is mainly found in various Bacteroides species. The function of this family is unknown.
Pfam PF20092: Family of unknown function (DUF6483) (family)
This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 119 and 132 amino acids in length.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF04584: Poxvirus A28 family (family)
Family of conserved Poxvirus A28 family proteins. Conserved region spans entire protein in the majority of family members.
Pfam PF04887: Poxvirus M2 protein (family)
This family includes M2 protein from variola virus.  The function of this protein is not known.
Pfam PF10536: Plant mobile domain (domain)
This domain was identified by Babu and colleagues in a variety of transposases.
Pfam PF21094: Nup188 SH3-like domain (domain)
Nup188 is one of the many peptides that make up the nucleoporin complex (NPC), and is found across eukaryotes. The Nup188 subcomplex (Nic96p-Nup188p-Nup192p-Pom152p) is one of at least six that make up the NPC, and as such is symmetrically localised on both faces of the NPC at the nuclear end, being integrally bound to the C terminus of Pom34p. This protein folds into an extended stack of helices where the N-terminal forms a closed ring (subdivided into subdomains I-III in) and the C-terminal forms a more regular, superhelical structure. This entry represents a beta-stranded SH3-like domain inserted in subdomain III from Nup188 N-terminal region, which is a circular permutation from canonical SH3 domain.
Pfam PF16129: Domain of unknown function (DUF4841) (domain)
this domain is found on the N-terminal of several uncharacterize proteins found in various Bacteroides  species. Solved structure of one of them (BACOVA_00967)  from Bacteroides ovatus shows a small beta barrel with  an immunoglobulin-like fold. DUF4841 domain shows weak      overlap with the DUF4114 family, suggesting a possible  distant relation. Function of this domain is unknown.
Pfam PF12889: Protein of unknown function (DUF3829) (family)
This is a small family of proteins from several bacterial species, whose function is not known. It may, however, be related to the GvpL_GvpF family of proteins, [pfam:PF06386].
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF05758: Ycf1 (family)
The chloroplast genomes of most higher plants contain two giant open reading frames designated ycf1 and ycf2. Although the function of Ycf1 is unknown, it is known to be an essential gene.
Pfam PF17406: Nrap protein PAP/OAS1-like domain 5 (domain)
Members of this family are nucleolar RNA-associated proteins (Nrap) which are highly conserved from yeast (Saccharomyces cerevisiae) to human. In the mouse, Nrap is ubiquitously expressed and is specifically localised in the nucleolus. Nrap is a large nucleolar protein (of more than 1000 amino acids). Nrap appears to be associated with ribosome biogenesis by interacting with pre-rRNA primary transcript.
Pfam PF10778: Halocarboxylic acid dehydrogenase DehI (family)
Haloacid dehalogenases catalyse the removal of halides from organic haloacids. DehI can process both L- and D-substrates.  A crucial aspartate residue is predicted to activate a water molecule for nucleophilic attack of the substrate chiral centre resulting in an inversion of the configuration of either L- or D-substrates in contrast to D-only enzymes.
Pfam PF01108: Tissue factor (family)
This family is found in metazoa, and is very similar to the fibronectin type III domain.  The family is found in cytokine receptors, interleukin and interferon receptors and coagulation factor III proteins. It occurs multiple times, as does fn3, family [pfam:PF00041].
Pfam PF04456: Protein of unknown function (DUF503) (family)
Family of hypothetical bacterial proteins.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF10813: Herpesvirus UL11 homologue (family)
This entry contains viral proteins that are involved in virion envelopment and egress. It includes Epstein-Barr virus (EBV) BBLF1 protein (also known as cytoplasmic envelopment protein 3), which is present in the tegument layer of EBV and is involved in virion maturation. BBLF1 also participates in viral entry at the fusion step probably by regulating the core fusion machinery. BBLF1 has been shown to localise to the trans-Golgi network along with gp350/220, a site where final envelopment of EBV particles takes place. BBLF1 shares 13 to 15% amino acid sequence identity with the herpes simplex virus 1 UL11 and cytomegalovirus UL99 tegument proteins, and like these it is a myristoylated and palmitoylated protein.
Pfam PF13600: N-terminal domain of unknown function (DUF4140) (family)
This family is often found at the N-terminus of its member proteins, with DUF4139, [pfam:PF13598], at the C-terminus.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF09964: Uncharacterized protein conserved in bacteria (DUF2198) (family)
This domain, found in various hypothetical bacterial proteins, has no known function.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF10658: Protein of unknown function (DUF2484) (family)
A role of this family in UDP-N-acetylenolpyruvoylglucosamine reductase, as MurB, could not be confirmed.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF23104: Sixth Zinc fingers C2H2 type, ZNF451 (domain)
This entry represents the sixth Zinc Finger C2H2 type found in the ZNF451 protein. E3 SUMO-protein ligase ZNF451 is a key enzyme involved in the sumoylation process, exhibiting a preference for SUMO2 and SUMO3 over SUMO1. It facilitates the UBE2I/UBC9-mediated sumoylation of target proteins, particularly in response to DNA damage and proteasome inhibitors. ZNF451 is essential for MCM4 sumoylation,  and it negatively regulates transcriptional activation mediated by the SMAD4 complex in the context of TGF-beta signaling. Additionally, it inhibits EP300-mediated acetylation of histone H3 at 'Lys-9'.
Pfam PF21683: Mu phage baseplate assembly protein GpP-like, N-terminal (domain)
This domain is found at the N-terminal end of Mu phage baseplate assembly protein GpP from Shewanella oneidensis and similar proteins predominantly found in tailed bacteriophages and bacterial prophages.
Pfam PF18599: Limiting CO2-inducible proteins B/C beta carbonyic anhydrases (domain)
Limiting CO2-inducible B protein (LCIB)-LCIC complex plays an important role in the microalgal CO2-concentrating mechanisms (CCMs).LCIB and homologs (LCIB1-4 and LCIC) structurally resemble beta carbonyic anhydrases (b-CAs) with striking similarities in overall fold, zinc-binding motif, and especially putative active site architecture.
Pfam PF05449: Putative 3TM holin, Phage_holin_3 (domain)
This is a family of putative proteobacterial phage three-transmembrane-domain holins.
Pfam PF12452: Protein of unknown function (DUF3685) (family)
This domain family is found in bacteria and eukaryotes, and is approximately 190 amino acids in length. There are two completely conserved residues (L and D) that may be functionally important.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF16650: Unstructured region on SPEG complex protein (disordered)
SPEG_u2 is a region of natively unstructured but conserved sequence on Striated muscle-specific serine/threonine-protein kinase proteins in higher eukaryotes.  It lies between two I-set immunoglobulin, [pfam:PF07679], domains.  The function is not known.
Pfam PF24001: Family of unknown function (DUF7317) (family)
This family includes a group of short archaeal proteins, that are distantly related to [pfam:PF03683].
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF20945: Ribonuclease MRP protein subunit RMP1 (family)
This family represents Ribonuclease MRP protein subunit RMP1 from yeast, a component of ribonuclease MRP (RNase MRP), which is involved in rRNA processing in mitochondria. This protein is found only in RNase MRP and is involved in extensive interactions with RNA, contributing to the formation of the substrate binding pocket of MRP. It is, likely, orthologue to human NEPRO.