SII-SWORD/CoKE huggingface dataset:
Pfam PF20376: Domain of unknown function (DUF6671) (domain)
This family of proteins is functionally uncharacterised. It belongs to the PD-(D/E)XK nuclease superfamily suggesting it has a nuclease function. This family of proteins is found in bacteria. Proteins in this family are typically between 278 and 290 amino acids in length.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF02526: Glycophorin-binding protein (repeat)
This family contains glycophorin binding proteins from P. falciparum the malarial parasite. Glycophorin is a cell surface protein of erythrocytes. The Glycophorin binding protein contains a tandem 38 residue repeat. In [swissprot:P02895] the repeat occurs 11 times.
Pfam PF18556: Bacterial Tetracyclin repressor, C-terminal domain (domain)
This is the C-terminal tetracyclin repressor domain found in bacteria. Family members include TetR family transcriptional regulators Rv3249c and Rv1816 found in Mycobacterium tuberculosis. Palmitic acid (a fatty acid) and isopropyl laurate (a fatty acid ester), were identified as binding ligands to Rv3249c and Rv1816 respectively. Similar to other TetR family regulators, these proteins are alpha-helical dimeric proteins consisting of a smaller N-terminal DNA-binding domain and a larger C-terminal regulatory domain.
Pfam PF17810: Arginine decarboxylase helical bundle domain (domain)
This entry represents a helical bundle domain that is found between the two enzymatic domains of the arginine decarboxylases.
Pfam PF19698: Family of unknown function (DUF6197) (family)
This entry includes a member of a biosynthetic gene cluster (BGC).  This BGC (BGC0000703) is described by MIBiG as an example of the following biosynthetic class, saccharide. It includes a member from the kanamycin biosynthetic gene cluster from Streptomyces kanamyceticus. Structure prediction suggests these proteins contain five alpha helices forming a compact domain.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF15288: Zinc knuckle (domain)
This Zinc knuckle is found in FAM90A mammalian proteins.
Pfam PF14858: Cilia- and flagella-associated protein 54 (family)
This domain family is found in eukaryotes, and is typically between 542 and 565 amino acids in length. This entry represents the N-terminal region of the cilia- and flagella-associated protein 54 which is required for assembly and function of cilia and flagella.
Pfam PF03754: B3 domain-containing protein At2g31720-like (family)
This entry represents a group of uncharacterised plant proteins, including B3 domain-containing protein At2g31720 (also known as Protein AUXIN RESPONSE FACTOR 70) from Arabidopsis. These are DNA-binding proteins likely to be involved in stress response.
Pfam PF24631: Domain of unknown function (DUF7628) (domain)
This is a domain of unknown function found in uncharacterised sequences from Plasmodium and related sequences from Plasmodiidae.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF01629: Domain of unknown function DUF22 (family)
This domain is found in 1 to 3 copies in archaebacterial proteins.  The function of the domain is unknown. This family appears to be expanded in Archaeoglobus fulgidus.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF09505: Dimethylamine methyltransferase (Dimeth_PyL) (family)
This family consists of dimethylamine methyltransferases from the genus Methanosarcina. It is found in three nearly identical copies in each of Methanosarcina acetivorans, Methanosarcina barkeri, and Methanosarcina mazei. It is one of a suite of three non-homologous enzymes with a critical UAG-encoded pyrrolysine residue in these species (along with trimethylamine methyltransferase and monomethylamine methyltransferase). It demethylates dimethylamine, leaving monomethylamine, and methylates the prosthetic group of the small corrinoid protein MtbC. The methyl group is then transferred by methylcorrinoid:coenzyme M methyltransferase to coenzyme M. Note that the pyrrolysine residue is variously translated as K or X, or as a stop codon that truncates the sequence.
Pfam PF25111: AtTam9 family (family)
This entry represents the AtTam9 protein from Arabidopsis thaliana and related plant proteins. AtTam9 is a component of the AtYcf2-FtsHi complex. AtTam9 is a small soluble protein which mainly interacts with the NTD of FtsHi5, another component of the AtYcf2-FtsHi complex, and likely contributes to the local assembly and stability of the complex.
Pfam PF06017: Unconventional myosin tail, actin- and lipid-binding (domain)
Unconventional myosins, ie those that are not found in muscle, have the common, classical-type head domain, sometimes a neck with the IQ calmodulin-binding motifs, and then non-standard tails. These tails determine the subcellular localisation of the unconventional myosins and also help determine their individual functions. The family carries several different unconventional myosins, eg. Myo1f is expressed mainly in immune cells as well as in the inner ear where it can be associated with deafness, Myo1d has a lipid-binding module in their tail and is implicated in endosome vesicle recycling in epithelial cells. Myo1a, b, c and g from various eukaryotes are also found in this family.
Pfam PF22686: Exo-oligoalginate lyase-like, C-terminal domain (domain)
This domain is found at the C-terminal end of Exo-oligoalginate lyase from Saccharophagus degradans (Alg17C) and similar sequences from proteobacteria. Alg17C catalyses the depolymerisation of alginate through an exolytic mode of action, via a beta-elimination mechanism. This protein consists of two domains: an N-terminal imperfect alpha-barrel ([pfam:PF05426]) and a C-terminal beta-sheet domain ([pfam:PF07940] and this entry). This domain adopts an all-beta configuration.
Pfam PF20339: Family of unknown function (DUF6634) (family)
This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 106 and 169 amino acids in length.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF04133: Vacuolar protein sorting 55 (family)
Vps55 is involved in the secretion of the Golgi form of the soluble vacuolar carboxypeptidase Y, but not the trafficking of the membrane-bound vacuolar alkaline phosphatase.  Both Vps55 and obesity receptor gene-related protein are important for functioning membrane trafficking to the vacuole/lysosome of eukaryotic cells.
Pfam PF12260: Protein-kinase domain of FAM69 (family)
This is the C-terminal region of a family of FAM69 proteins from Metazoa and Viridiplantae that are active protein-kinases. The family members have a short transmembrane helix close to the N-terminus, and thereafter are highly enriched with cysteines. FAM69 proteins are localised to the endoplasmic reticulum. Many members also have a short EF-hand, calcium-binding, domain just upstream of the kinase domain. The exact function of the more N-terminal family is uncertain.
Pfam PF06560: Glucose-6-phosphate isomerase (GPI) (domain)
This family consists of several bacterial and archaeal glucose-6-phosphate isomerase (GPI) proteins ([ec:5.3.1.9]).
Pfam PF17939: Tetracyclin repressor-like, C-terminal domain (domain)
TetR family regulators are involved in the transcriptional control of multidrug efflux pumps, pathways for the biosynthesis of antibiotics, response to osmotic stress and toxic chemicals, control of catabolic pathways, differentiation processes, and pathogenicity. The TetR proteins identified in overm ultiple genera of bacteria and archaea share a common helix-turn-helix (HTH) structure in their DNA-binding domain. However, TetR proteins can work in different ways: they can bind a target operator directly to exert their effect (e.g. TetR binds Tet(A) gene to repress it in the absence of tetracycline), or they can be involved in complex regulatory cascades in which the TetR protein can either be modulated by another regulator or TetR can trigger the cellular response. TetR regulates the expression of the membrane-associated tetracycline resistance protein, TetA, which exports the tetracycline antibiotic out of the cell before it can attach to the ribosomes and inhibit protein synthesis. TetR blocks transcription from the genes encoding both TetA and TetR in the absence of antibiotic. The C-terminal domain is multi-helical and is interlocked in the homodimer with the helix-turn-helix (HTH) DNA-binding domain. This entry represents the C-terminal domain present in the Pseudomonas aeruginosa PsrA which regulates the fadBA5 beta-oxidation operon. Functional analysis of PsrA indicated its importance in regulating b-oxidative enzymes. It has also been suggested that PsrA, a member of the TetR family of repressors, could affect global gene expression including activation of rpoS.
Pfam PF11752: Protein of unknown function (DUF3309) (family)
This family is conserved in bacteria but its function is not known.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF20197: Family of unknown function (DUF6560) (family)
This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria, mainly Firmicutes. Proteins in this family are typically between 157 and 193 amino acids in length. There are three highly conserved residues, tryptophan, phenylalanine/ tyrosine and lysine.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF09048: Cro (domain)
Members of this family are involved in the repression of transcription by binding as a homodimer to palindromic DNA operator sites in phage lambda: they repress genes expressed in early phage development and are necessary for the late stage of lytic growth. These proteins have a secondary structure consisting of three alpha-helices and three beta-sheets, and dimerise through interactions between the two antiparallel beta-strands.
Wikipedia: In molecular biology, the Cro repressor family is a family of repressor proteins in bacteriophage lambda that includes the Cro repressor.
Pfam PF15163: Meiosis-expressed (family)
This family of proteins is essential for spermiogenesis.
Pfam PF18384: Unkempt Zinc finger domain 1 (Znf1) (domain)
This is CCCH zinc finger 1 domain found in Unkempt N-terminal region. Unkempt is an evolutionary conserved RNA-binding protein that regulates translation of its target genes and is required for the establishment of the early bipolar neuronal morphology. It carries six CCCH zinc fingers (ZnFs) forming two compact clusters, ZnF1-3 and ZnF4-6, that recognize distinct trinucleotide RNA substrates. These clusters, recognize an unexpectedly short stretch of RNA sequence-only three consecutive ribonucleotides-with a varying degree of specificity. ZnF1-3 binds to the UUA motif of RNA substrates.
Pfam PF08248: Tryptophyllin-3 skin active peptide (family)
PdT-3 or Tryptophyllin-3 peptide is a subfamily of the family Tryptophyllin and of the superfamily FSAP (Frog Skin Active Peptide).  Originally identified in skin extracts of Neotropical leaf frogs, Phyllomedusa sp. This subfamily has an average length of 13 amino acids. The pharmacological activity of the tryptophyllins remains to be established but it seems that these peptides possess an action on liver protein synthesis and body weight.
Pfam PF06003: Survival motor neuron protein (SMN), Tudor domain (domain)
This entry consists of several eukaryotic survival motor neuron (SMN) proteins and Survival of motor neuron-related-splicing factor 30 (SPF30). The Survival of Motor Neurons (SMN) protein, the product of the spinal muscular atrophy-determining gene, is part of a large macromolecular complex (SMN complex) that functions in the assembly of spliceosomal small nuclear ribonucleoproteins (snRNPs). The SMN complex functions as a specificity factor essential for the efficient assembly of Sm proteins on U snRNAs and likely protects cells from illicit, and potentially deleterious, non-specific binding of Sm proteins to RNAs. This is the Tudor domain of SMN and SPF30, in which an aromatic cage in the Tudor domain mediates dimethylarginine recognition by electrostatic stabilization through cation-pi interactions.
Wikipedia: Survival of motor neuron or survival motor neuron (SMN) is a protein that in humans is encoded by the SMN1 and SMN2 genes.
Pfam PF10894: Protein of unknown function (DUF2689) (family)
Members in this family of proteins are annotated as TrbD however currently no function is known.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF11639: REDY-like protein HapK (family)
This family of proteins represents HapK, a protein of unknown function, with two homologues PigK and RedY. The monomer structure of the protein contains a four-stranded anti parallel beta-sheet, three alpha-helices and a short C terminal tail which it uses for dimer formation. The surface of HapK has a deep cavity with consists of a kinked helix and a beta-four strand. HapK could be involved in prodigiosin biosynthesis, specifically the binding of a bipyrrole intermediate such as HBM or MBM.
Pfam PF21896: Talin IBS2B domain (domain)
This entry represents the Talin IBS2B domain. Talin is an adaptor protein that activates integrin family of cell adhesion molecules and couples them to the actin cytoskeleton. The integrin activation is known to involve binding of the talin FERM domain to membrane proximal sequences in the cytoplasmic domain of the integrin beta-subunit. IBS2 is a second integrin-binding site that has been identified near the C-terminal end of the talin rod. The crystal structure of IBS2 reveals two five-helix bundles, IBS2-A and IBS2-B, connected by a continuous helix. The Talin IBS2B domain is essential for integrin binding, binding to acidic phospholipids, and targeting to focal adhesions. The domain comprises a tandem pair of five-helix bundles with the same topology, comprising five anti-parallel alpha-helices. This entry represents the second of the two domains. This domain is also found in Talin rod domain-containing protein 1, an actin-binding protein that may have an oncogenic function and regulates cell proliferation, migration and invasion in cancer cells.
Pfam PF03533: SPO11 homologue (family)
Spo11 is a meiosis-specific protein that is responsible for the initiation of recombination during the early stages of meiosis through the formation of DNA double-strand breaks (DSBs) by a type II DNA topoisomerase-like activity . These DSBs initiate homologous recombination, which is required for chromosomal segregation and generation of genetic diversity during meiosis. Spo11 acts in conjunction with several other proteins, including Rec102 in yeast, to bring about meiotic recombination . Mouse and human homologues of Spo11 have been cloned and characterised. The proteins are 82% identical and share ~25% identity with other family members. Mouse Spo11 has been localised to chromosome 2H4, and human SPO11 to chromosome 20q13.2-q13.3, a region amplified in some breast and ovarian tumours .

Similarity between SPO11 and archaebacterial TOP6A proteins points to evolutionary specialisation of a DNA-cleavage function for meiotic recombination . Note that the yeast SPO11 protein shares far less similarity to other SPO11 proteins than the human and mouse homologues do to each other.
Pfam PF00325: Bacterial regulatory proteins, crp family (domain)
The Crp-type HTH domain is a DNA-binding, winged helix-turn-helix (wHTH) domain of about 70-75 amino acids present in transcription regulators of the crp-fnr family, involved in the control of virulence factors, enzymes of aromatic ring degradation, nitrogen fixation, photosynthesis, and various types of respiration. The Crp-Fnr family is named after the first members identified in Escherichia coli: the well characterised cyclic AMP receptor protein CRP or CAP (catabolite activator protein) and the fumarate and nitrate reductase regulator Fnr. Crp-type HTH domain proteins occur in most bacteria and in chloroplasts of red algae. The DNA-binding HTH domain is located in the C-terminal part; the N-terminal part of the proteins of the Crp-Fnr family contains a nucleotide-binding domain and a dimerization/linker helix occurs in between. The Crp-Fnr regulators predominantly act as transcription activators, but can also be important repressors, and respond to diverse intracellular and exogenous signals, such as cAMP, anoxia, redox state, oxidative and nitrosative stress, carbon monoxide, nitric oxide or temperature .
Wikipedia: In molecular biology, the CRP domain is a protein domain consisting of a helix-turn-helix (HTH) motif. It is found at the C-terminus of numerous bacterial transcription regulatory proteins. These proteins bind DNA via the CRP domain. These proteins are very diverse, but for convenience may be grouped into subfamilies on the basis of sequence similarity. This family groups together a range of proteins, including ANR, CRP, CLP, CysR, FixK, Flp, FNR, FnrN, HlyX and NtcA.
Pfam PF07836: DmpG-like communication domain (domain)
This domain is found towards the C-terminal region  of various aldolase enzymes. It consists of five  alpha-helices, four of which form an antiparallel helical bundle that plugs the C-terminus of the N-terminal TIM barrel domain. The communication domain is thought to play an important role in the heterodimerisation of the enzyme.
Wikipedia: In molecular biology, the DmpG-like communication domain is a protein domain found towards the C-terminal region of various aldolase enzymes. It consists of five alpha-helices, four of which form an antiparallel helical bundle that plugs the C terminus of the N-terminal TIM barrel domain. The communication domain is thought to play an important role in the heterodimerisation of the enzyme.
Pfam PF18913: Fructose-1-6-bisphosphatase, C-terminal domain (domain)
This entry represents the C-terminal domain of Fructose-1-6-bisphosphatase enzymes. According to ECOD this domain has a Rossmann-like fold.
Pfam PF08411: Exonuclease C-terminal (family)
This bacterial domain is found at the C-terminus of Exodeoxyribonuclease I/Exonuclease I ([pfam:PF00929]), which is a single-strand specific DNA nuclease affecting recombination and expression pathways.  The exonuclease I protein in E. coli is associated with DNA deoxyribophosphodiesterase (dRPase).
Pfam PF02001: Protein of unknown function DUF134 (family)
This family of archaeal proteins has no known function. A study suggests that some members may be G-quadruplex binding proteins.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF08113: Cytochrome c oxidase subunit IIa family (family)
This family consists of the cytochrome c oxidase subunit IIa family.  The bax-type cytochrome c oxidase from Thermus thermophilus is known as a two subunit enzyme. From its crystal structure, it was discovered that an additional transmembrane helix 'subunit IIa' spans the membrane.  This subunit consists of 34 residues forming one helix across the membrane. The presence of this subunit seems to be important for the function of cytochrome c oxidases.
Pfam PF10125: NADH dehydrogenase I, subunit N related protein (family)
This family comprises a set of NADH dehydrogenase I, subunit N related proteins found in archaea. Their exact function, has not, as yet, been determined.
Pfam PF13767: Domain of unknown function (DUF4168) (family)
This presumed domain is functionally uncharacterised.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF16673: TNF receptor-associated factor BIRC3 binding domain (coiled_coil)
This domain is found in TNF receptor-associated factor 1 and 2 (TRAF1 and TRAF2), where it binds to Baculoviral IAP repeat-containing protein 3 (BIRC3) (cIAP2).
Pfam PF22282: CydS-like protein (domain)
This entry represents the CydS subunit of the cytochrome bd oxidase. This protein is very short and forms a single alpha helix that is part of the complex.
Pfam PF10768: Class II flagellar assembly regulator (family)
The FliX protein is possibly a transient component of the flagellum that is required for the assembly process. FliX may contribute to the targeting or assembly of the P- and L-ring protein monomers at the cell pole. The family carries a potential N-terminal signal sequence and at least one transmembrane domain indicating that it might function either in or in association with the cell membrane.