SII-SWORD/CoKE huggingface dataset:
Pfam PF13256: Domain of unknown function (DUF4047) (family)
This presumed domain is functionally uncharacterised. This domain family is found in bacteria, and is approximately 130 amino acids in length. There are two conserved sequence motifs: TEA and FPKT.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF07877: Protein of unknown function (DUF1661) (domain)
This is a family containing bacterial proteins of unknown function.  Many of the proteins in this family are hypothetical.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF01736: Polyomavirus agnoprotein (family)
This family consist of the DNA binding protein or agnoprotein from various polyomaviruses. This protein is highly basic and can bind single stranded and double stranded DNA. Mutations in the agnoprotein produce smaller viral plaques, hence its function is not essential for growth in tissue  culture cells but something has slowed in the normal replication  cycle. There is also evidence suggesting that the agnogene and agnoprotein act as regulators of structural protein synthesis.
Wikipedia: Agnoprotein is a protein expressed by some members of the polyomavirus family from a gene called the agnogene. Polyomaviruses in which it occurs include two human polyomaviruses associated with disease, BK virus and JC virus, as well as the simian polyomavirus SV40.
Pfam PF00563: EAL domain (domain)
This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues. The EAL domain is a good candidate for a diguanylate phosphodiesterase function. The domain contains many conserved acidic residues  that could participate in metal binding and might form the phosphodiesterase active site.
Wikipedia: In molecular biology, the EAL domain is a conserved protein domain. It is found in diverse bacterial signalling proteins. It is named EAL after its conserved residues. The EAL domain may function as a diguanylate phosphodiesterase. The domain contains many conserved acidic residues that could participate in metal binding and might form the phosphodiesterase active site.
Pfam PF24817: WDHD1 first WD40 domain (repeat)
This is the WD40 domain found at the N-terminal of WDHD1 (also known as AND-1). WDHD1 is an adaptor molecule crucial for DNA replication. It is a core replisome component that acts as a replication initiation factor. It binds directly to the CMG complex and functions as a hub to recruit additional proteins to the replication fork.
Pfam PF03325: Herpesvirus polymerase accessory protein (family)
The same proteins are also known as polymerase processivity factors.
Pfam PF00587: tRNA synthetase class II core domain (G, H, P, S and T) (domain)
tRNA-synt_2b is a family of largely threonyl-tRNA members.
Pfam PF11227: Protein of unknown function (DUF3025) (family)
Some members in this bacterial family of proteins are annotated as transmembrane proteins however this cannot be confirmed. Currently this family of proteins has no known function.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF11158: Protein of unknown function (DUF2938) (family)
This bacterial family of proteins has no known function. Some members are thought to be membrane proteins however this cannot be confirmed.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF20593: Family of unknown function (DUF6793) (family)
This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 110 amino acids in length. Proteins in this family might have an RNA polymerase activity.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF15202: Adipogenin (family)
This family of proteins is involved in the stimulation of adipocyte differentiation and development.
Pfam PF00309: Sigma-54 factor, Activator interacting domain (AID) (family)
The sigma-54 holoenzyme is an enhancer dependent  form of the RNA polymerase.  The AID is necessary for activator interaction.  In addition, the AID also inhibits  transcription initiation in the sigma-54 holoenzyme prior to  interaction with the activator.
Wikipedia: The gene rpoN encodes the sigma factor sigma-54, a protein in Escherichia coli and other species of bacteria. RpoN antagonizes RpoS sigma factors.
Pfam PF04122: Cell wall binding domain 2 (CWB2) (domain)
This domain is found in 1 to 3 tandem copies in a wide variety of bacterial cell surface proteins. It has been show the three tandem repeats of the CWB2 domain are essential for correct anchoring to the cell wall. It was shown that in SlpA and Cwp2 that these domains were essential for the binding of PSII an anionic teichoic acid-like component of the cell wall. The structure of the Cwp8 and Cwp6 proteins shows that this domain forms a trimeric arrangement with each domain adopting a structure with some similarity to the Toprim fold. A groove containing many conserved residues was predicted to be the site of the PSII molecule.
Pfam PF14312: FG-GAP repeat (repeat)
This region contains the extracellular repeat that is found in up to seven copies in alpha integrins and related proteins. It forms a 7-fold repeat that adopts a Î²-propeller structure . The repeat is called the FG-GAP repeat after two conserved motifs in the repeat . The FG-GAP repeats are found in the N terminus of integrin alpha chains, a region that has been shown to be important for ligand binding . A putative Ca2+ binding motif is found in some of the repeats. These repeats are found in multiple proteins from eukaryotes and bacteria and mediate diverse biological processes at both molecular and cellular levels, such as cell-cell interactions, host patogen recognition or innate immune responses.
Pfam PF21181: SsfX3, N-terminal domain (domain)
This domain is found in the protein SsfX3 from Streptomyces sp. and in similar bacterial proteins. SsfX3 is an acyltransferase involved in the biosynthesis of the anticancer natural product SF2575. This protein is organised into two distinct domains: an N-terminal beta-sandwich (this entry) and a C-terminal catalytic domain (GDSL-like Lipase/Acylhydrolase domain, [pfam:PF13472]). This domain resembles a carbohydrate-binding module (CBM) domain and is critical for substrate binding.
Pfam PF24795: WRD62/MABP1 coiled-coil (coiled_coil)
This entry represents the coil-coiled domain of WDR62, which is required for its dimerization. WDR62 is a microcephaly-related, microtubule (MT)-associated protein (MAP) that localises to the spindle pole and regulates spindle organisation by recruiting katanin to the spindle pole by forming a complex with TPX2/Aurora A. This domain is also found in MABP1, a negative regulator of NOD2 function.
Pfam PF05731: TROVE domain (repeat)
This domain is found in TEP1 and Ro60 proteins, that are RNA-binding components of Telomerase, Ro and Vault RNPs. This domain has been named TROVE, (after Telomerase, Ro and Vault) and binds RNA. It consists of HEAT repeats that form a ring with a central hole as described in Ro proteins. The ring is closed by a von Willebrand factor A domain.
Pfam PF09891: Uncharacterized protein conserved in archaea (DUF2118) (family)
This domain, found in various hypothetical archaeal proteins, has no known function.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF06479: Ribonuclease 2-5A (family)
This domain is a endoribonuclease. Specifically it cleaves an intron from Hac1 mRNA in humans, which causes it to be much more efficiently translated.
Pfam PF04088: Peroxin 13, N-terminal region (family)
Both termini of the Peroxin-13 are oriented to  the cytosol. Peroxin-13 is required for peroxisomal  association of peroxin-14.
Wikipedia: Peroxins represent several protein families found in peroxisomes. Deficiencies are associated with several peroxisomal disorders. Peroxins serve several functions including the recognition of cytoplasmic proteins that contain peroxisomal targeting signals (PTS) that tag them for transport by peroxisomal proteins to the peroxisome. Peroxins are structurally diverse and have been classified to different protein families. Some of them were predicted to be single-pass transmembrane proteins, for example Peroxisomal biogenesis factor 11.
Pfam PF18089: DAPG hydrolase PhiG domain (domain)
This domain is found in 2,4-diacetylphloroglucinol hydrolase PhiG present in Pseudomonas fluorescens. 2,4-diacetylphloroglucinol hydrolase is the gene product of PhiG that is responsible for cleaving toxic 2,4-diacetylphloroglucinol (DAPG). The small N-terminal region of the domain is involved in dimerization through hydrogen bonding of the dimer interface. The C-terminal catalytic region resembles the tetracenomycin aromatase/cyclase and has a Bet v1-like fold. DAPG PhiG is the first discovered hydrolase whose catalytic domain belongs to the Bet v1-like fold, rather than the classical alpha/beta-fold hydrolases.
Pfam PF08535: KorB domain (domain)
This family consists of several KorB transcriptional repressor proteins. The korB gene is a major regulatory element in the replication and maintenance of broad host-range plasmid RK2. It negatively controls the replication gene trfA, the host-lethal determinants kilA and kilB, and the korA-korB operon. This domain includes the DNA-binding HTH motif.
Pfam PF04664: Opioid growth factor receptor (OGFr) conserved region (family)
Opioid peptides act as growth factors in neural and non-neural cells and tissues, in addition to serving in neurotransmission/neuromodulation in the nervous system. The Opioid growth factor receptor is an integral membrane protein associated with the nucleus. The conserved region is situated at the N-terminus of the member proteins with a series of imperfect repeats lying immediately to its C-terminus.
Wikipedia: Opioid growth factor receptor, also known as OGFr or the ζ-opioid receptor, is a protein which in humans is encoded by the OGFR gene. The protein encoded by this gene is a receptor for opioid growth factor (OGF), also known as [Met(5)]-enkephalin. The endogenous ligand is thus a known opioid peptide, and OGFr was originally discovered and named as a new opioid receptor zeta (ζ). However it was subsequently found that it shares little sequence similarity with the other opioid receptors, and has quite different function.
Pfam PF00992: Troponin (family)
Troponin (Tn) contains three subunits, Ca2+ binding (TnC), inhibitory (TnI), and tropomyosin binding (TnT).  this Pfam contains members of the TnT subunit. Troponin is a complex of three proteins, Ca2+ binding (TnC), inhibitory (TnI), and tropomyosin binding (TnT).  The troponin complex regulates Ca++ induced muscle contraction. This family includes troponin T and troponin I.  Troponin I binds to actin and troponin T binds to tropomyosin.
Pfam PF04364: DNA polymerase III chi subunit, HolC (family)
The DNA polymerase III holoenzyme ([ec:2.7.7.7]) is the polymerase responsible for the replication of the Escherichia coli chromosome.  The holoenzyme is composed of the DNA polymerase III core, the sliding clamp, and the DnaX clamp loading complex. The DnaX complex contains either either the tau or gamma product of gene dnax, complexed to delta.delta' and to chi psi. Chi forms a 1:1 heterodimer with psi.  The chi psi complex functions by increasing the affinity of tau and gamma for delta.delta' allowing a functional clamp-loading complex to form at physiological subunit concentrations.  Psi is responsible for the interaction with DnaX (gamma/tau), but psi is insoluble unless it is in a complex with chi.
Wikipedia: DNA polymerase III holoenzyme is the primary enzyme complex involved in prokaryotic DNA replication. It was discovered by Thomas Kornberg and Malcolm Gefter in 1970. The complex has high processivity and, specifically referring to the replication of the E.coli genome, works in conjunction with four other DNA polymerases. Being the primary holoenzyme involved in replication activity, the DNA Pol III holoenzyme also has proofreading capabilities that corrects replication mistakes by means of exonuclease activity reading 3'→5' and synthesizing 5'→3'. DNA Pol III is a component of the replisome, which is located at the replication fork.
Pfam PF24925: Domain of unknown function (DUF7746) (domain)
This presumed domain is found in a group of plant sequences, whose function is unknown. This domain may adopt a three-helical bundle fold.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF21682: CDP-alcohol phosphatidyltransferase AF_2299-like, N-terminal (domain)
This domain is found at the N-terminal end of CDP-alcohol phosphatidyltransferase family protein from Archaeoglobus fulgidus (AF_2299) and similar archaeal proteins. AF_2299 is a member of a family of membrane-embedded enzymes known as CDP-alcohol phosphotransferases (CDP-APs) involved in the formation of polar phospholipids. This integral membrane phosphotransferase is organised into two distinct domains. This entry represents the N-terminal cytoplasmic domain, which has structural similarity to the cytidyltransferases.
Pfam PF07222: Proacrosin binding protein sp32 (family)
This family consists of several mammalian specific proacrosin binding protein sp32 sequences. sp32 is a sperm specific protein which is known to bind with with 55- and 53-kDa proacrosins and the 49-kDa acrosin intermediate. The exact function of sp32 is unclear, it is thought however that the binding of sp32 to proacrosin may be involved in packaging the acrosin zymogen into the acrosomal matrix.
Pfam PF05136: Phage portal protein, lambda family (family)
This protein forms a hole, or portal, that enables DNA passage during packaging and ejection.  It also forms the junction between  the phage capsid and the tail proteins.
Pfam PF24016: Domain of unknown function (DUF7330) (repeat)
This entry represents a domain found in uncharacterised proteins, mainly from fungi. This domain may consist of beta-solenoid repeats. This entry shows distant similarity to [pfam:PF13349].
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF06563: Protein of unknown function (DUF1125) (family)
This family consists of several short Lactococcus lactis and bacteriophage proteins. The function of this family is unknown.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF20272: Cysteine-rich domain, C-terminal to E2 domain (domain)
Cysteine-rich domain observed C-terminal to certain E2 domains which are part of prokaryotic Ubiquitin systems found as secondary effector modules in nucleotide-activated effector conflict systems.
Pfam PF24417: Family of unknown function (DUF7549) (family)
This entry represents a group of uncharacterised archaeal proteins. They are predicted to adopt alpha/beta structure consisting of five-stranded antiparallel beta-sheet and five alpha-helices protruding from it.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF08758: Cadherin prodomain like (domain)
Cadherins are a family of proteins that mediate calcium dependent cell-cell adhesion.  They are activated through cleavage of a prosequence in the late Golgi.  This domain corresponds to the folded region of the prosequence, and is termed the prodomain. The prodomain shows structural resemblance to the cadherin domain, but lacks all the features known to be important for cadherin-cadherin interactions.
Pfam PF09440: eIF3 subunit 6 N terminal domain (domain)
This is the N terminal domain of subunit 6 translation initiation factor eIF3.
Pfam PF19305: MmgE/PrpD C-terminal domain (domain)
This entry represents the C-terminal domain of 2-methylcitrate dehydratase [ec:4.2.1.79] (PrpD) that is required for propionate catabolism. It catalyses the third step of the 2-methylcitric acid cycle. This domain is related to the serine dehydratase beta chain.
Pfam PF15131: Domain of unknown function (DUF4567) (family)
This family of proteins is functionally uncharacterised. This family of proteins is found in some mammals.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF08564: Cdc37 C terminal domain (domain)
Cdc37 is a protein required for the activity of numerous eukaryotic protein kinases.  This domains corresponds to the C terminal domain whose function is unclear.  It is found C terminal to the Hsp90 chaperone (Heat shocked protein 90) binding domain [pfam:PF08565] and the N terminal kinase binding domain of Cdc37 [pfam:PF03234].
Wikipedia: Hsp90 co-chaperone Cdc37 is a protein that in humans is encoded by the CDC37 gene. This protein is highly similar to Cdc 37, a cell division cycle control protein of Saccharomyces cerevisiae. This protein is a HSP90 Co-chaperone with specific function in cell signal transduction. It has been shown to form complex with Hsp90 and a variety of protein kinases including CDK4, CDK6, SRC, RAF1, MOK, as well as eIF-2 alpha kinases. It is thought to play a critical role in directing Hsp90 to its target kinases.
Pfam PF10677: Protein of unknown function (DUF2490) (family)
This is a bacterial family of uncharacterised proteins. They appear to belong to the outer membrane beta barrel superfamily.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF10468: Carboxypeptidase inhibitor I68 (domain)
This is a family of tick carboxypetidase inhibitors.
Wikipedia: In biology and biochemistry, protease inhibitors, or antiproteases, are molecules that inhibit the function of proteases. Many naturally occurring protease inhibitors are proteins.
Pfam PF05021: NPL4 family (family)
The HRD4 gene was identical to NPL4, a gene previously implicated in nuclear transport. Using a diverse set of substrates and direct ubiquitination assays, analysis revealed that HRD4/NPL4 is required for a poorly characterised step in ER-associated degradation after ubiquitination of target proteins but before their recognition by the 26S proteasome. Npl4p physically associates with Cdc48p via Ufd1p to form a Cdc48p-Ufd1p-Npl4p complex. The Cdc48-Ufd1-Npl4 complex functions in the recognition of several polyubiquitin-tagged proteins and facilitates their presentation to the 26S proteasome for processive degradation or even more specific processing.
Pfam PF15145: Domain of unknown function (DUF4577) (family)
The function of this family of proteins, has not, as yet, been determined. Members of this family are as yet uncharacterised. This family of proteins is found in eukaryotes. Proteins in this family are typically 128 amino acids in length.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.