SII-SWORD/CoKE huggingface dataset:
Pfam PF24158: Domain of unknown function (DUF7409) (domain)
This is a domain of unknown function found in uncharacterised archaeal sequences.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF02222: ATP-grasp domain (domain)
This family does not contain all known ATP-grasp domain members. This family includes a diverse set of enzymes that possess ATP-dependent carboxylate-amine ligase activity.
Pfam PF04619: Dr-family adhesin (family)
This family of adhesins bind to the Dr blood group antigen component of decay-accelerating factor.  This mediates adherence of uropathogenic Escherichia coli to the urinary tract.  This family contains both fimbriated and afimbriated adherence structures.  This protein also confers the phenotype of mannose-resistant hemagglutination, which can be inhibited by chloramphenicol.  The N terminal portion of the protein is though to be responsible for chloramphenicol sensitivity.
Pfam PF20836: Hypothetical protein NE1300 (family)
The conversion of hydroxylamine to nitrite in nitrifying bacteria is catalysed by Hydroxylamine oxidoreductase (HAO). Hypothetical protein NE1300 from Nitrosomonas europaea seems to be a binding partner of HAO in vivo that may play a structural role in the ternary complex with cytochrome c554, the physiological electron acceptor of HAO. However, its exact function is not clear.
Pfam PF16243: Sm_like domain (domain)
This domain, approximately 150 residues, is mainly found in several uncharacterized proteins in various Prochlorococcus and Synechococcus species. The crystal structure of ECX21941 reveals unexpected similarity to Sm/LSm proteins, which are important RNA-binding proteins, despite no detectable sequence similarity. The specific function of this family is unknown, but the structure analysis of ECX21941 indicates nucleic acid-binding capabilities and suggests a role in RNA and/or DNA processing.
Pfam PF04284: Protein of unknown function (DUF441) (family)
Predicted to be an integral membrane protein.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF16355: Domain of unknown function (DUF4982) (domain)
This domain is found towards the C terminus of Beta-glucuronidase from Formosa agariphila (P17_GH2) and similar proteins mainly from bacteria and fungi. P17_GH2 is involved in the degradation of the polysaccharide ulvan. The function of this domain, which shows an all-beta structure, is unknown.
Pfam PF19084: Family of unknown function (DUF5775) (family)
This is a family of uncharacterised proteins of unknown function, found in phycodnaviruses. The protein contains a predicted N-terminal transmembrane helix.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF11530: Minor type IV pilin, PilX (family)
PilX is a protein from Neisseria meningitidis which is crucial for the formation of bacterial aggregates and adhesion to human cells. The structure of PilX is similar to all pilins as it has the common alpha/beta roll fold. PilX subunits have surface-exposed motifs which are thought to stabilise bacterial aggregates against pilus retraction. It also illustrates how a minor pilus component can modulate the virulence properties of pili which have a simple composition and structure.
Pfam PF04848: Poxvirus A22 protein (family)
This family representis the Poxvirus A22 protein, a Holliday junction resolvase also known as Resolvase OPG149, and similar proteins from poxvirus. It specifically cleaves and resolves four-way DNA Holliday junctions into linear duplex products .
Pfam PF14325: Domain of unknown function (DUF4383) (family)
This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 137 and 164 amino acids in length.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF07000: Protein of unknown function (DUF1308) (domain)
This is a domain of unknown function found on the C-terminal of C7orf25 protein UPF0415. The C-terminal domain is homologous to the known PIN-like domains. The PIN-like domain is widespread among eukaryotes, including animals, plants, and fungi, but also present in some cyanobacteria, Deinococcus, and dsDNA viruses from the Mimiviridae family. The domain retains up to four potential catalytic residues, thus, depending on the protein is predicted to be an active or inactive nuclease and in a majority of the family members, the PIN-like domain is N-terminally fused with a potentially active PD-(D/E)XK-like domain [pfam:PF18474].
Wikipedia: C7orf25 protein UPF0415 (UPF0415) is a protein encoded on chromosome 7, in open reading frame 25 (C7orf25) and are located at domain of unknown function 1308. C7orf25 is located at the minus strand and encodes 12 proteins, one of them being UPF0415. This protein is believed to be active in the proteosome pathway. C7orf25 protein UPF0415 is not a transmembrane protein and has no signal peptide. UPF0415 has two isoforms, Q9BPX7-1 and Q9BPX7-2. Both consists of two exons that are both highly conserved among vertebrates.
Pfam PF20360: Family of unknown function (DUF6655) (family)
This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 205 and 301 amino acids in length.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF05289: Borrelia hemolysin accessory protein (family)
This family consists of several borrelia hemolysin accessory proteins (BLYB). BLYB was thought to be an accessory protein, which was proposed to comprise a hemolysis system but it is now thought that BlyA and BlyB function instead as a prophage-encoded holin or holin-like system.
Pfam PF12623: RNA repair, ligase-Pnkp-associating, region of Hen1 (domain)
This domain is the N-terminal region of the bacterial Hen1 protein.  This protein forms stable hetero-tetramer with Pnkp. The hetero-tetramer was able to repair transfer RNAs cleaved by ribotoxins in vitro. This domain provides the ligase activity of the hetero-tetramer.
Pfam PF01612: 3'-5' exonuclease (domain)
This domain is responsible for the 3'-5' exonuclease proofreading activity of E. coli DNA polymerase I (polI) and other enzymes, it catalyses the hydrolysis of unpaired or mismatched nucleotides. This domain consists of the amino-terminal half of the Klenow fragment in E. coli polI it is also found in the Werner syndrome helicase (WRN), focus forming activity 1 protein (FFA-1) and ribonuclease D (RNase D).  Werner syndrome is a human genetic disorder causing premature aging; the WRN protein has helicase activity in the 3'-5' direction.  The FFA-1 protein is required for formation of a replication foci and also has helicase activity; it is a homologue of the WRN protein. RNase D is a 3'-5' exonuclease involved in tRNA processing. Also found in this family is the autoantigen PM/Scl thought to be involved in polymyositis-scleroderma overlap syndrome.
Pfam PF11922: Domain of unknown function (DUF3440) (family)
This presumed domain is functionally uncharacterised. This domain is found in bacteria. This domain is typically between 53 to 190 amino acids in length. This domain is found associated with [pfam:PF01507]. This domain has a conserved KND sequence motif.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF02290: Signal recognition particle 14kD protein (domain)
The signal recognition particle (SRP) is a multimeric protein involved in targeting secretory proteins to the rough endoplasmic reticulum membrane. SRP14 and SRP9 form a complex essential for  SRP RNA binding.
Pfam PF10909: Protein of unknown function (DUF2682) (family)
This viral family of proteins has no known function.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF23399: LTI65/LTI78 PGEED repeat (disordered)
This entry represents a disordered region found in LTI78/LTI65 from Arabidopsis thaliana and related plant proteins. LTI78/LTI65 are involved in responses to abiotic stresses. This region consists of repeats containing the conserved PGEED sequence and is located C-terminal of the CAP160 repeat ([pfam:PF07918]).
Pfam PF09902: Uncharacterized protein conserved in bacteria (DUF2129) (family)
This domain, found in various hypothetical prokaryotic proteins, has no known function. Structural modelling suggests this domain may bind nucleic acids. According to structure predictions, members of this entry are distantly related to SNaCT domains (CLan:CL0806).
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF16787: Centromere DNA-binding protein complex CBF3 subunit, domain 2 (domain)
NDC10_II is a the second of five domains on the Kluyveromyces lactis Ndc10 protein. Each subunit of the Ndc10 dimer binds a separate fragment of DNA, suggesting that Ndc10 stabilises a DNA loop at the centromere.
Pfam PF07652: Flavivirus DEAD domain (domain)
The non-structural protein NS3 from flavivirus is a bifunctional protein that contains an N-terminal protease (IPR001850) and a C-terminal helicase domains that plays an essential role in viral polyprotein processing and genome replication. The N-terminal domain is a chymotrypsin-like serine protease, which is responsible for most of the maturation cleavages of the polyprotein precursor in the cytosolic side of the endoplasmic reticulum membrane. The C-terminal domain, is a helicase belonging to superfamily 2 (SF2) that unwinds the dsRNA and removes the gamma-phosphate at the 5'-RNA prior to RNA cap addition .

This entry represents the DEAD-box domain from flavivirus NS3 helicase domain. This domain is also found in a group of potyviruses, which are plant viruses, such as Zucchini yellow mosaic virus, Plum pox potyvirus and Tobacco etch virus.
Pfam PF17365: Family of unknown function (DUF5390) (family)
This is a family of unknown function found in Caenorhabditis.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF13253: Protein of unknown function (DUF4044) (family)
This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 42 and 56 amino acids in length. There is a single completely conserved residue M that may be functionally important.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF02843: Phosphoribosylglycinamide synthetase, C domain (domain)
Phosphoribosylglycinamide synthetase catalyses the second step in the de novo biosynthesis of purine. The reaction catalysed by Phosphoribosylglycinamide synthetase is the ATP- dependent addition of 5-phosphoribosylamine to glycine to form 5'phosphoribosylglycinamide. This domain is related to the C-terminal domain of biotin carboxylase/carbamoyl phosphate synthetase (see [pfam:PF02787]).
Pfam PF24671: Dynein regulatory complex subunit 7 C-terminal (domain)
Dynein regulatory complex subunit 7 (DRC7) is a component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. In humans, defective ciliary motility can lead to male infertility and a congenital disorder called primary ciliary dyskinesia (PCD), in which impaired clearance of mucus by the cilia causes chronic respiratory infections. This entry represents the C-terminal domain, which consists of two alpha-helices.
Pfam PF21550: Myosin A tail domain interacting protein, N-terminal (domain)
This domain is found at the N-terminal end of Myosin A tail domain interacting protein from Plasmodium falciparum (MTIP) and in similar eukaryotic sequences. MTIP is one of the proteins that empower host cell invasion. This domain adopts an EF hand configuration.
Pfam PF18385: T-lymphoma invasion and metastasis CC-Ex domain (domain)
This is the CC and Ex subdomains found in PH-CC-Ex globular domain from Tiam1 and Tiam2 proteins (T-lymphoma invasion and metastasis). The CC subdomain forms an antiparallel coiled coil with two long alpha-helices, together with the C-terminal Ex subdomain they form a small globular domain comprising three alpha-helices. The CC subdomain of the Tiam2 PHCCEx domain follows the C-terminal alpha1 helix of the PH [pfam:PF00169] subdomain through a four-residue linker.
Pfam PF21196: PcrA/UvrD tudor domain (domain)
The PcrA/UvrD helicase binds directly to RNA polymerase (RNAP). This entry represents the C-terminal tudor domain that mediates interaction with RNA polymerase.
Pfam PF17498: Family of unknown function (DUF5433) (family)
This is a family of unknown function found in Orthopoxviruses.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF02670: 1-deoxy-D-xylulose 5-phosphate reductoisomerase (family)
This is a family of 1-deoxy-D-xylulose 5-phosphate reductoisomerases.  This enzyme catalyses the formation of 2-C-methyl-D-erythritol 4-phosphate from 1-deoxy-D-xylulose-5-phosphate in the presence of NADPH. This reaction is part of the terpenoid biosynthesis pathway.
Wikipedia: DXP reductoisomerase is an enzyme that interconverts 1-deoxy-D-xylulose 5-phosphate (DXP) and 2-C-methyl-D-erythritol 4-phosphate (MEP).
Pfam PF23977: Pam3 phage gp34-like protein (family)
This entry represents an uncharacterised family of phage proteins related to Pam3 phage gp34 protein.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF16859: Tetracyclin repressor-like, C-terminal domain (domain)
This family of bacterial transcriptional repressors is characterised by the short approximately 50 amino acid stretch of residues constituting the helix-turn-helix DNA binding motif, around the YRFhY motif. The target proteins that are repressed are involved in the transcriptional control of multi-drug efflux pumps, pathways for the biosynthesis of antibiotics, response to osmotic stress and toxic chemicals, control of catabolic pathways, differentiation processes, and pathogenicity.
Pfam PF08288: PIGA (GPI anchor biosynthesis) (family)
This domain is found on phosphatidylinositol n-acetylglucosaminyltransferase proteins. These proteins are involved in GPI anchor biosynthesis and are associated with disease the paroxysmal nocturnal haemoglobinuria.
Pfam PF18784: CRM1 / Exportin repeat 2 (repeat)
Chromosome region maintenance 1 / Exportin 1 mediates the nuclear  transport of proteins bearing a leucin-rich nuclear export signal  (NES). It contains helical repeats that are structurally similar to HEAT repeats, but share little sequence similarity with them. N-, C-terminal and central repeats show slightly different structural arrangements, with N- and C- terminal repeats interacting with each  other. This Pfam entry includes some CRM1 repeats that fail to be  detected with the [pfam:PF18777] model.
Pfam PF14874: Flagellar-associated PapD-like (domain)
This domain is a putative PapD periplasmic pilus chaperone protein family.
Pfam PF23316: DLEC1 sixth Ig-like domain (domain)
This domain is found in Deleted in lung and esophageal cancer protein 1 DLEC1 and related proteins. This protein is essential for spermatogenesis and male fertility and may play a role in the sperm head and tail formation. The domain represented by this entry is predicted to adopt an Ig-like fold.
Pfam PF06414: Zeta toxin (domain)
This family consists of several bacterial zeta toxin proteins. Zeta toxin is thought to be part of a postregulational killing system in bacteria. It relies on antitoxin/toxin systems that secure stable inheritance of low and medium copy number plasmids during cell division and kill cells that have lost the plasmid.
Wikipedia: In molecular biology, the protein domain Zeta (ζ) toxin refers to a protein domain found in prokaryotes, which acts as a UDP-N-acetylglucosamine kinase. Its function is to inhibit cell wall biosynthesis and it may act as a bactericide in nature. It is also thought that Zeta toxin induces reversible protective dormancy and permeation to propidium iodide (PI).
Pfam PF02412: Thrombospondin type 3 repeat (domain)
The thrombospondin repeat is a short aspartate rich repeat which binds to calcium ions. The repeat was initially identified in thrombospondin proteins that contained 7 of these repeats. The repeat lacks defined secondary structure.
Pfam PF15278: Sec3 exocyst complex subunit (repeat)
This small Sec3 C-terminal domain family is based around the fission yeast protein, and is rather shorter than the budding yeast/vertebrate domain Sec3_C, family. [pfam:PF09763]. In fact it is only this coiled-coil region that they carry in common. The full length fission yeast, UniProtKB:Q10324, protein Sec3 is redundant with Exo70 for viability and for the localisation of other exocyst subunits, suggesting that these components act as exocyst tethers at the plasma membrane. Sec3, Exo70 and Sec5 are transported by the myosin V Myo52 along actin cables. The exocyst holo-complex, including Sec3 and Exo70, is present on exocytic vesicles, which can reach cell poles by either myosin-driven transport or random walk.
Pfam PF23111: PEX6 N1 domain (domain)
This entry represents a domain found at the N-terminal, described as N1 domain in, of a set of PEX6 proteins from Saccharomycetes, including PEX6 from S.cerevisiae. PEX6 is a component of the PEX1-PEX6 AAA ATPase complex, involved in peroxisome biogenesis, as they are required for the import of folded proteins into the peroxisomal matrix. PEX6 proteins have tandem N-terminal domains, N1 and N2, which are a unique feature. According to structure predictions, the N1 domain may adopt a double-psi barrel fold.
Pfam PF05390: Yeast cell wall synthesis protein KRE9/KNH1 C-terminal (domain)
This is the C-terminal domain found in KRE9 and KNH1 proteins which are involved in encoding cell surface O glycoproteins, required for beta -1,6-glucan synthesis in yeast. In Saccharomyces cerevisiae, a kre9 null mutation leads to severe growth defects, aberrant multi-budded morphology, and mating defects. Over-expression of Knh1 suppresses growth defects of a kre9 null mutant. Knh1 is required for propionic acid resistance.
Pfam PF13562: Sugar nucleotidyl transferase (domain)
This is a probable sugar nucleotidyl transferase family.
Pfam PF10930: Protein of unknown function (DUF2737) (family)
This family of proteins has no known function.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF03511: Fanconi anaemia group A protein C-terminal domain (repeat)
This domain is found toward C terminus of human Fanconi anaemia group A protein and related proteins. It contains ARM repeats.
Wikipedia: Fanconi anaemia, complementation group A, also known as FAA, FACA and FANCA, is a protein which in humans is encoded by the FANCA gene. It belongs to the Fanconi anaemia complementation group (FANC) family of genes of which 12 complementation groups are currently recognized and is hypothesised to operate as a post-replication repair or a cell cycle checkpoint. FANCA proteins are involved in inter-strand DNA cross-link repair and in the maintenance of normal chromosome stability that regulates the differentiation of haematopoietic stem cells into mature blood cells.