SII-SWORD/CoKE huggingface dataset:
Pfam PF15960: Domain of unknown function (DUF4763) (family)
This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and eukaryotes. Proteins in this family are typically between 237 and 332 amino acids in length. There are two completely conserved residues (C and R) that may be functionally important.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF23749: Domain of unknown function (DUF7165) (repeat)
This entry represents a domain of unknown function found towards the N-terminal of fungal proteins. This domain adopts a beta-propeller like fold and may be found in association with an N-terminal F-box motif.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF10452: TORC1 subunit TCO89 (disordered)
TC089 is a component of the TORC1 complex.  TORC1 is responsible for a wide range of rapamycin-sensitive cellular activities.
Pfam PF00986: DNA gyrase B subunit, carboxyl terminus (family)
The amino terminus of eukaryotic and prokaryotic DNA topoisomerase II are similar, but they have a different carboxyl terminus. The amino-terminal portion of the DNA gyrase B protein is thought to catalyse the ATP-dependent super-coiling of  DNA. See [pfam:PF00204]. The carboxyl-terminal end supports the  complexation with the DNA gyrase A protein and the ATP-independent  relaxation. This family also contains Topoisomerase IV. This is a bacterial enzyme that is closely related to DNA gyrase,.
Pfam PF20867: UVSSA N-terminal domain (repeat)
This alpha solenoid repeat domain is found at the N-terminus of the UV-stimulated scaffold protein A.
Pfam PF22891: Eukaryotic type KH-domain (KH-domain type I) (327.11.2) (domain)
This entry represents the second KH domain found in the PNO1 protein. PNO1 is part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit.
Pfam PF04367: Protein of unknown function (DUF502) (family)
Predicted to be an integral membrane protein.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF18716: Vms1-associating treble clef domain (domain)
Treble clef fold domain found at C-terminus of many, but not all, Vms1/ANKZF1-like proteins.
Pfam PF20282: C-terminal domain 6 of the ABC-three component (ABC-3C) systems (domain)
C-terminal domains (CTDs) of ABC-3C systems, contain distinct patterns of charged and polar residues and are not yet unifiable with known domains. These domains are found at the C-terminus of the effector component of the systems, which are upstream of the Middle Component and ABC ATPase components on the genome. Due to the typically large size of these CTDs relative to the actual effector and MC domains, the CTDs are predicted to serve as the platform on which the remaining two components assemble. Therewith, conformational changes transmitted by the ABC ATPase-mediated detection of invasive elements like DNA viruses would result in an unfurling and activation of the CTD-associated effector.
Pfam PF21937: YscD/CdsD-like Bon-like domain 2 (domain)
Yop-YscD-ppl is the periplasmic domain of Yop proteins like YscD from Proteobacteria. YscD forms part of the inner membrane component of the bacterial type III secretion injectosome apparatus. This entry represents the second of three periplasmic BON domains.
Pfam PF19791: Family of unknown function (DUF6275) (family)
This family of proteins is functionally uncharacterised. This family of proteins is found in Firmicute bacteria and their phage. Proteins in this family are approximately 90 amino acids in length.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF08999: Surfactant protein C, N terminal propeptide (domain)
The N-terminal propeptide of surfactant protein C adopts an alpha-helical structure, with turn and extended regions. It's main function is the stabilisation of metastable surfactant protein C (SP-C), since the latter can irreversibly transform from its native alpha-helical structure to beta-sheet aggregates and form amyloid-like fibrils. The correct intracellular trafficking of proSP-C has also been reported to depend on the propeptide.
Wikipedia: Surfactant protein C (SP-C), is one of the pulmonary surfactant proteins. In humans this is encoded by the SFTPC gene.
Pfam PF12965: Domain of unknown function (DUF3854) (domain)
A family of uncharacterised proteins found by clustering human gut metagenomic sequences. This domain is likely to be related to the Toprim domain.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF13667: ThiC-associated domain (domain)
This domain is most frequently found at the N-terminus of the ThiC family of proteins, [pfam:PF01964]. The function is not known.
Pfam PF14413: Thg1 C terminal domain (domain)
Thg1 polymerases contain an additional region of conservation C-terminal to the core palm domain that comprise of 5 helices and two strands. This region has several well-conserved charged residues  including a basic residue found towards the end of the first helix  of this unit might contribute to the Thg1-specific active site. This C-terminal module of Thg1 is predicted to form a helical bundle  that functions equivalently to the fingers of the other nucleic acid  polymerases, probably in interacting with the template HtRNA.
Pfam PF21599: Zinc finger SWIM domain-containing protein 3, N-terminal (domain)
This entry represents the N-terminal domain of ZSWIM3, a ZSWIM-type zinc finger domain containing protein whose function is not yet known. This domain appears to be related to the WRKY-like DNA-binding domains.
Pfam PF00739: Trans-activation protein X (family)
This protein is found in hepadnaviruses where it is indispensable for replication.
Pfam PF14377: Ubiquitin binding region (conserved_site)
This family contains repetitive element (RE) from a subgroup of HECT E3 ubiquitin ligases and the Y-family translesion polymerases, including human HUWE1 and Arabidopsis UPL1. Each of these repetitive elements are approximately 20 amino acids in length and contain two predicted helical segments separated by a Leu-Pro motif. The REs from the Y-family polymerases were shown to bind ubiquitin and were the basis for a novel ubiquitin-binding domain called the ubiquitin-binding motif (UBM).
Pfam PF15103: G0/G1 switch protein 2 (family)
This family of proteins regulate apoptosis by binding to Bcl-2 and preventing the formation of the anti-apoptotic BAX-BCL2 heterodimers.
Pfam PF02774: Semialdehyde dehydrogenase, dimerisation domain (domain)
This Pfam entry contains the following members: N-acetyl-glutamine semialdehyde dehydrogenase (AgrC) Aspartate-semialdehyde dehydrogenase.
Wikipedia: In enzymology, an aspartate-semialdehyde dehydrogenase is an enzyme that is very important in the biosynthesis of amino acids in prokaryotes, fungi, and some higher plants. It forms an early branch point in the metabolic pathway forming lysine, methionine, leucine and isoleucine from aspartate. This pathway also produces diaminopimelate which plays an essential role in bacterial cell wall formation. There is particular interest in ASADH as disabling this enzyme proves fatal to the organism giving rise to the possibility of a new class of antibiotics, fungicides, and herbicides aimed at inhibiting it.
Pfam PF14367: Domain of unknown function (DUF4411) (family)
This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and archaea. Proteins in this family are typically between 153 and 170 amino acids in length. There is a single completely conserved residue D that may be functionally important.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF15005: Izumo sperm-egg fusion, Ig domain-associated (family)
This IZUMO family is a domain just upstream of the immunoglobulin domain on Izumo proteins in higher eukaryotes. The actual function of this region of the Izumo proteins is not known. The full-length protein is a molecule with a single immunoglobulin (Ig) domain. It is thought that Izumo proteins bind to putative Izumo receptors on the oocyte.  Izumo is not detectable on the surface of fresh sperm but becomes exposed only after an exocytotic process, the acrosome reaction, has occurred. Studies have shown that knock-out mice (Izumo-/- males) were sterile despite normal mating behaviour and ejaculation, indicating the importance of the protein in fertilisation.  There are cysteine residues thought to form a disulphide bridge. Izumo is a typical type I membrane glycoprotein with one immunoglobulin-like domain and a putative N-glycoside link motif (Asn 204). There is a conserved GCL sequence motif. Izumo expression has been found to be testis-specific.
Pfam PF19361: Family of unknown function (DUF5937) (family)
This family of proteins is functionally uncharacterised but contains a C-terminal DNA-binding HTH domain. This family is distantly related to [pfam:PF02624] suggesting it is likely to be a ligand binding domain. This family of proteins is found in actinobacteria and firmicutes. Proteins in this family are typically between 326 and 366 amino acids in length.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF13556: PucR C-terminal helix-turn-helix domain (domain)
This helix-turn-helix domain is often found at the C-terminus of PucR-like transcriptional regulators such as [swissprot:O32138] and is likely to be DNA-binding.
Pfam PF09178: 4-alpha-glucanotransferase, C-terminal (domain)
Members of this family, which are predominantly found in prokaryotic 4-alpha-glucanotransferase, adopt a structure composed of six antiparallel beta-strands, four of which form a beta-sheet and another two form a type I' beta-hairpin. The role of this family of domains, has not, as yet, been defined.
Pfam PF14799: FAM195 family (family)
This family consist of Mapk-regulated corepressor-interacting protein 1 (MCRIP1) and 2 (MCRIP2). MCRIP1 binds to and inhibits the transcriptional co-repressor CtBP. MCRIP1 is an ERK substrate; when phosphorylated by ERK, MCRIP1 releases CtBP to induce chromatin modifications .
Pfam PF16674: N-terminal of ubiquitin carboxyl-terminal hydrolase 37 (domain)
UCH_N is a domain found at the N-terminus of ubiquitin carboxyl-terminal hydrolase 37 or 26. The function is not known.
Pfam PF01778: Ribosomal L28e protein family (family)
Ribosomal protein eL28 forms part of the 60S ribosomal subunit . This entry is found in eukaryotes. In rat there are 9 or 10 copies of the eL28 gene. The eL28 protein contains a possible internal duplication of 9 residues .
In budding yeast, Mak16 forms part of the 66S pre-ribosomal particles and functions as a transacting actor involved in rRNA processing .

This entry represents a ribosomal L28e domain that also matches the N-terminal region of Mak16.
Wikipedia: Ribosomal L28e protein family  is a family of evolutionarily related proteins. Members include 60S ribosomal protein L28.
Pfam PF20435: Meiosis-specific protein ASY3-like (family)
This entry represents a group of plant meiosis-specific proteins, such as AtASY3 from Arabidopsis and PAIR3 from rice. They are coiled-coil domain proteins required for normal meiosis. PAIR3 is an axial element and part of the synaptonemal complex (SC) that forms between homologous chromosomes during meiosis. Members of this family are homologues of SCYP2 from vertebrates and fungal Red1/Rec10.
Pfam PF12732: YtxH-like protein (family)
This family of proteins is found in bacteria. Proteins in this family are typically between 100 and 143 amino acids in length. The N-terminal region is the most conserved. Proteins is this family are functionally uncharacterised.
Pfam PF15355: Stretch-responsive small skeletal muscle X protein, Chisel (family)
The murine X-linked gene Chisel (Csl/Smpx) is selectively expressed in cardiac and skeletal muscle cells. It localises to the costameric cytoskeleton of muscle cells through its association with focal adhesion proteins, where it may participate in regulating the dynamics of actin through the Rac1/p38 kinase pathway. Thus it is implicated in the maintenance of muscle integrity and in responses to biomechanical stress.
Pfam PF17254: Family of unknown function (DUF5321) (family)
This is a family of unknown function. Most of the members seem to carry one trans-membrane region.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF20492: Ezrin/radixin/moesin, alpha-helical domain (coiled_coil)
The ERM family consists of three closely-related proteins, ezrin, radixin and moesin. Ezrin was first identified as a constituent of microvilli, radixin as a barbed, end-capping actin-modulating protein from isolated junctional fractions, and moesin as a heparin binding protein. A tumour suppressor molecule responsible for neurofibromatosis type 2 (NF2) is highly similar to ERM proteins and has been designated merlin (moesin-ezrin-radixin-like protein). ERM molecules contain 3 domains, an N-terminal globular domain, an extended alpha-helical domain and a charged C-terminal domain ([pfam:PF00769]). Ezrin, radixin and merlin also contain a polyproline linker region between the helical and C-terminal domains. The N-terminal domain is highly conserved and is also found in merlin, band 4.1 proteins and members of the band 4.1 superfamily, designated the FERM domain. ERM proteins crosslink actin filaments with plasma membranes. They co-localise with CD44 at actin filament plasma membrane interaction sites, associating with CD44 via their N-terminal domains and with actin filaments via their C-terminal domains. This is the alpha-helical domain, which is involved in intramolecular masking of protein-protein interaction sites, regulating the activity of this proteins.
Wikipedia: The ERM protein family consists of three closely related proteins, ezrin, radixin and moesin. The three paralogs, ezrin, radixin and moesin, are present in vertebrates, whereas other species have only one ERM gene. Therefore, in vertebrates these paralogs likely arose by gene duplication.
Pfam PF25134: Domain of unknown function (DUF7821) (domain)
This domain is found N-terminal in uncharacterised protein PM0657 and its paralogue PM1082 from Pasteurella multocida and related bacterial proteins. It is predicted to adopt a alpha/beta globular structure consisting of a central antiparallel beta- sheet and helices packed on both sides.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF03795: YCII-related domain (domain)
The majority of proteins in this family consist of a single copy of this domain, though it is also found as a repeat ([swissprot:Q9AJZ7]). A strongly conserved histidine and a aspartate suggest that the domain has an enzymatic function.  This family also now includes the family formerly known as the DGPF domain (COG3795). Although its function is unknown it is found fused to a sigma-70 factor family domain in [swissprot:Q9A8M4].  Suggesting that this domain plays a role in transcription initiation (Bateman A per. obs.). This domain is named after the most conserved motif in the alignment.
Pfam PF04999: Cell division protein FtsL (coiled_coil)
In Escherichia coli, nine gene products are known to be essential for assembly of the division septum. One of these, FtsL, is a bitopic membrane protein whose precise function is not understood. It has been proposed that FtsL interacts with the DivIC protein [pfam:PF04977], however this interaction may be indirect.
Pfam PF13830: Domain of unknown function (DUF4192) (family)
This protein family is functionally uncharacterised.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF25008: Domain of unknown function (DUF7784) (domain)
This domain is found in uncharacterised fungal proteins. It is predicted to adopt an up-and-down four-helical bundle.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF03017: TNP1/EN/SPM transposase (family)
Proteins in this group are TNP1/EN/SPM-like transposon proteins with no known function from plants .
Pfam PF10860: Protein of unknown function (DUF2661) (family)
This viral family of proteins have no known function.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF20301: Predicted novel nucleotide synthetase (family)
Conserved genome contexts in NAD+-derived nucleotide-activated effector systems predict a function as a previously-uncharacterised nucleotide synthetase.
Pfam PF00459: Inositol monophosphatase family (family)
It has been shown that several proteins share two sequence motifs . Two of these proteins, vertebrate and plant inositol monophosphatase (3.1.3.25), and vertebrate inositol polyphosphate 1-phosphatase (3.1.3.57), are enzymes of the inositol phosphate second messenger signalling pathway, and share similar enzyme activity. Both enzymes exhibit an absolute requirement for metal ions (Mg2 is preferred), and their amino acid sequences contain a number of conserved motifs, which are also shared by several other proteins related to MPTASE (including products of fungal QaX and qutG, bacterial suhB and cysQ, and yeast hal2) . The function of the other proteins is not yet clear, but it is suggested that they may act by enhancing the synthesis or degradation of phosphorylated messenger molecules .

Structural analysis of these proteins has revealed a common core of 155 residues, which includes residues essential for metal binding and catalysis. An interesting property of the enzymes of this family is their sensitivity to Li+. The targets and mechanism of action of Li+ are unknown, but overactive inositol phosphate signalling may account for symptoms of manic depression .
Pfam PF20568: Domain of unknown function (DUF6777) (domain)
This presumed domain is functionally uncharacterised. This domain family is found in bacteria, and is approximately 160 amino acids in length.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF09720: Putative addiction module component (family)
This entry defines several short bacterial proteins, typically about 75 amino acids long, which are always found as part of a pair (at least) of small genes. The other protein in the pair always belongs to a family of plasmid stabilisation proteins (IPR007712). It is likely that this protein and its partner comprise some form of addiction module - a pair of genes consisting of a stable toxin and an unstable antitoxin which mediate programmed cell death - although these gene-pairs are usually found on the bacterial main chromosome.
Pfam PF06166: Protein of unknown function (DUF979) (family)
This family consists of several putative bacterial membrane proteins. The function of this family is unclear.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.