SII-SWORD/CoKE huggingface dataset:
Pfam PF04488: Glycosyltransferase sugar-binding region containing DXD motif (family)
The DXD motif is a short conserved motif found in many families of glycosyltransferases, which add a range of different sugars to other  sugars, phosphates and proteins.  DXD-containing glycosyltransferases all  use nucleoside diphosphate sugars as donors and require divalent cations,  usually manganese.  The DXD motif is expected to play a carbohydrate  binding role in sugar-nucleoside diphosphate and manganese dependent glycosyltransferases.
Wikipedia: The Clostridial Cytotoxin (CCT) Family is a member of the RTX-toxin superfamily. There are currently 13 classified members belonging to the CCT family. A representative list of these proteins is available in the Transporter Classification Database. Homologues are found in a variety of Gram-positive and Gram-negative bacteria.
Pfam PF12766: Pyridoxamine 5'-phosphate oxidase (family)
Pyridoxamine 5'-phosphate oxidase catalyses the oxidation of pyridoxamine-5-P (PMP) and pyridoxine-5-P (PNP) to pyridoxal-5-P (PLP), the terminal step in the de novo biosynthesis of PLP in Escherichia coli and part of the salvage pathway of this coenzyme in both E. coli and mammalian cells. This region is the flavoprotein FMN-binding domain.
Pfam PF23130: IcmW (family)
This entry represent the type 4 adapter protein IcmW from Legionella pneumophila and related proteins found mainly in Gammaproteobacteria. IcmW is a component of Type 4B secretion (T4BS) system that translocates over 300 effectors into the host cell during infection. This protein is part of a subcomplex which recruits effector proteins and delivers them to the core transmembrane subcomplex. In the membrane-embedded T4 coupling complex (T4CC), the DotLMNYZ components form a hetero-pentameric core of the T4CC complex from which the flexible IcmSW module protrudes. These hetero-pentameric complexes assemble and form an inner membrane channel for effectors to pass through. The IcmS/IcmW complex plays an important role in protein translocation by interacting with multiple Dot/Icm effector proteins to facilitate their translocation into host cells. The binding of the IcmSW complex to effectors enhances the effector protein delivery by mediating a conformational change that facilitates T4SS recognition of a translocation domain located in the carboxyl region of the effector protein.
Pfam PF09685: Domain of unknown function (DUF4870) (family)
This entry represents a large group of uncharacterised conserved proteins. Their function is not clear.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF23439: Domain of unknown function (DUF7124) (domain)
This domain is found in a group of proteins from halobacteria. It has several W and R conserved residues. This domain is predicted to show an alpha-beta configuration.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF22579: Carbohydrate binding module-like (domain)
This entry represents a Carbohydrate binding module from Ruminococcus flavefaciens (Cbm74-rfgh5) and similar sequences predominantly from clostridia. This domain adopts a beta- sandwich fold typical of carbohydrate binding modules (CBMs).
Pfam PF20119: Family of unknown function (DUF6509) (family)
This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 100 amino acids in length. There are two conserved sequence motifs: DPTGI and ILA.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF18697: Murine leukemia virus (MLV) integrase (IN) C-terminal domain (domain)
This is the C-terminal domain (CTD) which can be found in murine leukemia virus (MLV) integrase (IN) proteins. The MLV IN C-terminal domain interacts with the bromo and extraterminal (BET) proteins through the ET domain. This interaction provides a structural basis for global in vivo integration-site preferences andt disruption of this interaction through truncation mutations affects the global targeting profile of MLV. The CTD consists an SH3 fold followed by a long unstructured tail.
Pfam PF24725: Domain of unknown function (DUF7677) (domain)
This entry represents a group of uncharacterised proteins found in bacteria. These proteins are predicted to adopt globular structure that folds into a three helical bundle.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF12166: Piezo non-specific cation channel, cap domain (domain)
This is an extracellular domain at the C-terminus of Piezo, or FAM38 mechanosensitive non-specific cation channel proteins. Piezo is a family of proteins that form mechanosensitive non-specific cation channels whose conductance is higher for Li+, intermediate for Na+ and lowest for Li+. Divalent ions except for Mn2+ permeate the channel but more slowly than monovalent ions and can reduce K+ currents. These channels have a homotrimeric three-blade propeller-shaped structure that use a cap-motion and plug-and-latch mechanism to gate their ion-conducting pathways. Each protomer consists of 38 TM helices that form unusual non-planar blades, and an extracellular cap-like structure, the latter represented in this entry. This domain is embedded in the centre of the trimer and may control the transmembrane constriction site suggested to act as a transmembrane gate. This domain adopts a distinctive beta-sandwich fold.
Pfam PF04176: TIP41-like family (family)
The TOR signalling pathway activates a cell-growth program in response to nutrients. TIP41 interacts with TAP42 and negatively regulates the TOR signaling pathway.
Pfam PF23846: WalK sensor protein kinase Chache domain (domain)
This entry represents the Cache domain found in the sensor protein kinase WalK (or YycG) from bacteria. The WalK protein, alongside its response regulator WalR, is part of a two-component signal transduction system involved in diverse cellular processes, including cell wall metabolism, virulence regulation, biofilm production, among many other cellular processes. This domain is extracellular and is involved in WalK dimerization necessary for protein function.
Pfam PF14726: Rotatin, an armadillo repeat protein, centriole functioning (family)
Rotatin and its homologues such as Ana3 in Drosophila are found to be essential for centriole function. A deficiency of rotatin in mice leads to randomised heart tube looping, defects in embryonic turning, and abnormal expression of HNF3beta, lefty, and nodal. Thus it is required for left-right and axial patterning. Ana3 - the Drosophila homologue - is present in centrioles and basal bodies, is required for the structural integrity of both centrioles and basal bodies and for centriole cohesion. Rotatin also localises to centrioles and basal bodies and appears to be essential for cilia function. This family represents the N-terminal domain.
Pfam PF00171: Aldehyde dehydrogenase family (family)
This family of dehydrogenases act on aldehyde substrates. Members use NADP as a cofactor. The family includes the following members: The prototypical members are the aldehyde dehydrogenases [swissprot:P00352] [ec:1.2.1.3]. Succinate-semialdehyde dehydrogenase [swissprot:P25526] [ec:1.2.1.16]. Lactaldehyde dehydrogenase [swissprot:P25553] [ec:1.2.1.22]. Benzaldehyde dehydrogenase [swissprot:P43503] [ec:1.2.1.28]. Methylmalonate-semialdehyde dehydrogenase [swissprot:Q02252] [ec:1.2.1.27]. Glyceraldehyde-3-phosphate dehydrogenase [swissprot:P81406] [ec:1.2.1.9]. Delta-1-pyrroline-5-carboxylate dehydrogenase [swissprot:P30038] EC: 1.5.1.12. Acetaldehyde dehydrogenase [swissprot:P17547] [ec:1.2.1.10]. Glutamate-5-semialdehyde dehydrogenase [swissprot:P07004] [ec:1.2.1.41]. This family also includes omega crystallin [swissprot:P30842] an eye lens protein from squid and octopus that has little aldehyde dehydrogenase activity.
Wikipedia: Aldehyde dehydrogenases are a group of enzymes that catalyse the oxidation of aldehydes. They convert aldehydes to carboxylic acids. The oxygen comes from a water molecule. To date, nineteen ALDH genes have been identified within the human genome. These genes participate in a wide variety of biological processes including the detoxification of exogenously and endogenously generated aldehydes.
Pfam PF20017: vWA-MoxR associated protein middle region (VMAP-M) 15 (family)
Highly variable central region of the vWA-MoxR associated protein (VMAP) of the classical ternary system (vWA-MoxR-VMAP) in NTP-dependent conflict systems. VMAP-Ms may be involved in sensing of invasive entities.
Pfam PF03943: TAP C-terminal domain (domain)
The vertebrate Tap protein is a member of the NXF family of shuttling transport receptors for nuclear export of mRNA. Tap has a modular structure, and its most C-terminal domain is important for binding to FG repeat-containing nuclear pore proteins (FG-nucleoporins) and is sufficient to mediate nuclear shuttling. The structure of the C-terminal domain is composed of four helices. The structure is related to the UBA domain.
Wikipedia: Nuclear RNA export factor 1, also known as NXF1 or TAP, is a protein which in humans is encoded by the NXF1 gene.
Pfam PF20240: Domain of unknown function (DUF6597) (domain)
This presumed domain is found at the N-terminus of bacterial transcription factor proteins, suggesting that this may be a regulatory domain that binds to some as yet unknown ligand.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF02872: 5'-nucleotidase, C-terminal domain (domain)
This entry is the C-terminal domain of 5'-nucleotidases.
5'-nucleotidases 3.1.3.5  are enzymes that catalyse the hydrolysis of phosphate esterified at carbon 5' of the ribose and deoxyribose portions of nucleotide molecules. 5'-nucleotidase is a ubiquitous enzyme found in a wide variety of species and which occurs in different cellular locations. The extracellular 5'-nucleotidase from mammals and Discopyge ommata (Electric ray) isozyme is a homodimeric disulphide-bonded glycoprotein attached to the membrane by a GPI-anchor, and requires zinc for its activity. Vibrio parahaemolyticus 5'-nucleotidase (gene nutA) is bound to the membrane by a lipid chain, and requires chloride and magnesium ions for its activity. It is involved in degrading extracellular 5'-nucleotides for nutritional needs.

Periplasmic bacterial 5'-nucleotidase (gene ushA), also known as UDP-sugar hydrolase 3.6.1.45, can degrade UDP-glucose and other nucleotide diphosphate sugars. It produces sugar-1-phosphate which can then be used by the cell. UshA seems to require cobalt for its activity. 5'-Nucleotidases are evolutionary related to the periplasmic bacterial 2',3'-cyclic-nucleotide 2'-phosphodiesterase 3.1.4.16 (gene cpdB), which catalyzes two consecutive reactions: it first converts 2',3'-cyclic-nucleotide to 3'-nucleotide and then acts as a 3'-nucleotidase; and mosquito apyrase 3.6.1.5 (ATP-diphosphohydrolase) , which catalyzes the hydrolysis of ATP into AMP and facilitates hematophagy by preventing ADP-dependent platelet aggregation in the host.

CD73 (also called ecto-5'-nucleotidase) possesses the enzymatic activity of a 5'-nucleotidase and catalyses the dephosphorylation of purine and pyrimidine ribo-and deoxyribonucleoside monophosphates to their corresponding nucleosides. Triggering of lymphocyte CD73 with mAb causes phosphorylation and dephosphorylation of certain, yet unknown protein substrates . A possible function for CD73 is to regulate the availability of adenosine for interaction with cell surface adenosine receptor by converting AMP to adenosine. In common with other GPI anchored surface proteins CD73 can mediate costimulatory signals in T cell activation .
Pfam PF21606: Beta-galactosidase-like, Galactose-binding domain (domain)
This domain is found in Beta-galactosidase from Streptococcus pneumoniae (BgaA) and similar bacterial sequences. BgaA is specific for terminal galactose residues beta-1-4 linked to glucose or N-acetylglucosamine. It is involved in pneumococcal growth, resistance to opsonophagocytic killing, and adherence. This entry represents two non-enzymatic carbohydrate-binding modules (CBMs) that mediate adherence to the host cell surface displayed lactose or N-acetyllactosamine. Each of these CBMs folds into a beta-sandwich fold comprising opposing sheets of 4- and 5-antiparallel beta-strands.
Pfam PF08241: Methyltransferase domain (domain)
Members of this family are SAM dependent methyltransferases.
Pfam PF14086: Domain of unknown function (DUF4266) (domain)
This presumed lipoprotein domain is functionally uncharacterised. This domain family is found in bacteria, and is approximately 50 amino acids in length.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF00725: 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain (domain)
This family also includes lambda crystallin. Some proteins include two copies of this domain.
Pfam PF21977: Domain of unknown function (DUF6926) (domain)
This domain of unknown function is found in bacterial proteins. It is probably distantly related to dodecin. It is predicted to adopt a simple fold consisting of a core of 3 strands, forming a curved sheet, and two short helices.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF16027: Domain of unknown function (DUF4786) (family)
This family of proteins is functionally uncharacterised. This family of proteins is found in eukaryotes. Proteins in this family are typically between 209 and 353 amino acids in length.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF18186: SMODS and SLOG-associating 2TM effector domain family 4 (domain)
The SLATT domain contains two transmembrane helices. SLATT domains are generally predicted to function as pore-forming effectors in a class of conflict systems which are reliant on the production of second messenger nucleotide or nucleotide derivatives. SLATT domains are predicted to initiate cell suicide responses upon their activation. This SLATT family is often coupled to the SMODS nucleotide synthetase and is sometimes further embedded in other conflict systems like CRISPR/Cas or R-M systems.
Pfam PF20784: DUF5575 C-terminal domain (domain)
This entry represents the C-terminal domain from a family of Chordate proteins that includes C19orf68. These proteins appear to be transposon related.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF19399: Family of unknown function (DUF5974) (family)
This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0000576) is described by MIBiG as an example of the following biosynthetic class, RiPP (ribosomally synthesised and post-translationally modified peptide).
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF20818: Protelomerase, stirrup domain (domain)
This domain is found in Protelomerase from Klebsiella phage phiKO2 (TelK) and similar proteins from tailed bacteriophages and bacterial prophages mainly from Gammaproteobacteria. TelK is a hairpin telomere resolvase with DNA cleavage-rejoining activity that resolves the catenated circular dimer produced from the bidirectional replication of a chromosome. The core of the TelK monomer consists of an N-terminal domain and a catalytic domain connected by a long alpha- helical linker. However, there are two extensions of the protein: a C-terminal DNA binding domain named the stirrup (this entry) and a N-terminal core binding domain. This domain, which shows alpha- helical and beta-hairpin segments, binds to DNA using the winged helix-turn-helix motif and contacts the DNA flanking the cleavage site, extending the DNA binding interface. It is essential for the orientation and extent of DNA bending and for the refolding of cleaved DNA strands into hairpins.
Pfam PF06918: Protein of unknown function (DUF1280) (family)
This family represents a conserved region approximately 200 residues long within a number of proteins of unknown function that seem to be specific to C. elegans.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF14631: Fanconi anaemia protein FancD2 nuclease (family)
The Fanconi anaemia protein FancD2 is a nuclease necessary for the repair of DNA interstrand-crosslinks.
Pfam PF19898: Domain of unknown function (DUF6371) (domain)
This domain of unknown function is found in uncharacterised bacterial proteins. This domain is about 150 amino acids in length.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF18825: Large polyvalent protein-associated domain 13 (domain)
This is an alpha and beta domain that is found in polyvalent proteins of both conjugative elements and phages/prophages.
Pfam PF15506: OCC1 family (family)
The human member of this family, overexpressed in colon carcinoma 1 protein ([swissprot:Q8TAD7]) has been shown to be overexpressed in several colon carcinomas.
Pfam PF13334: Domain of unknown function (DUF4094) (family)
This domain is found in plant proteins that often carry a galactosyltransferase domain, [pfam:PF01762], at their C-terminus.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF09739: Mini-chromosome maintenance replisome factor (family)
This entry is of proteins of approximately 600 residues in length containing alternating regions of conservation and low complexity.  The Arabidopsis protein is a replisome factor found to bind with the mini-chromosome maintenance, MCM-binding, complex and is crucial for efficient DNA replication. The family now spans the full-length proteins.
Pfam PF07249: Cerato-platanin (family)
This family contains a number of fungal cerato-platanin phytotoxic proteins approximately 150 residues long. Cerato-platanin contains four cysteine residues that form two disulphide bonds.
Wikipedia: In molecular biology, the cerato-platanin family of proteins includes the phytotoxin cerato-platanin (CP) produced by the Ascomycete Ceratocystis platani. CP homologs are also found in both the Ascomycota and the Basidiomycota branches of Dikarya. This toxin causes the severe plant disease: canker stain. This protein occurs in the cell wall of the fungus and is involved in the host-pathogen interaction and induces both cell necrosis and phytoalexin synthesis which is one of the first plant defense-related events. CP, like other fungal surface proteins, is able to self-assemble in vitro. CP is a 120 amino acid protein, containing 40% hydrophobic residues. It is one of the rare examples of protein in which contains a Hopf link. The link is formed by covalent loops - the pieces of protein backbone closed by two disulphide bonds. The N-terminal region of CP is very similar to cerato-ulmin, a phytotoxic protein produced by the Ophiostoma species belonging to the hydrophobin family, which also self-assembles.
Pfam PF08480: Disaggregatase related (repeat)
This domain is found in disaggregatases and several hypothetical proteins of the archaeal genus Methanosarcina. Disaggregatases cause aggregates to separate into single cells and contain parallel beta-helix repeats.  Also see [pfam:PF06848].