SII-SWORD/CoKE huggingface dataset:
Pfam PF19497: Family of unknown function (DUF6032) (family)
This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0001410) is described by MIBiG as an example of the following biosynthetic class, saccharide. This family includes a  protein from the polysaccharide A biosynthetic gene cluster from  Bacteroides fragilis.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF06257: Biofilm formation stimulator VEG (family)
VEG is a family that is highly conserved among Gram-positive bacteria. It stimulates biofilm formation through inducing transcription of the tapA-sipW-tasA operon. The products of this operon are resposible for production of the amyloid fibre (TasA) component of the biofilm. Veg or a Veg-induced protein acts as an antirepressor of SinR - part of the major overall biofilm transcriptional control system - to regulate and stimulate biofilm formation. Veg is transcribed at high levels during both exponential growth and sporulation.
Pfam PF21628: Major coat protein-like (domain)
This protein family includes Major coat protein from Salmonella phage epsilon15 (Gp10) and similar sequences from tailed bacteriophages and from bacterial prophages. Gp10 binds to the outer surface of the virus capsid. It adopts a jellyroll viral protein fold with two sheets consisting of four beta-strands each.
Pfam PF07922: Glycosyltransferase family 52 (family)
This family features glycosyltransferases belonging to glycosyltransferase family 52, which have alpha-2,3- sialyltransferase ([ec:4.2.99.4]) and alpha-glucosyltransferase (EC 2.4.1.-) activity. For example, beta-galactoside alpha-2,3- sialyltransferase expressed by Neisseria meningitidis ([swissprot:P72097]) is a member of this family and is involved in a step of lipooligosaccharide  biosynthesis requiring sialic acid transfer; these lipooligosaccharides  are thought to be important in the process of pathogenesis. This family includes several bacterial lipooligosaccharide sialyltransferases similar to the Haemophilus ducreyi LST protein. Haemophilus ducreyi is the cause of the sexually transmitted disease chancroid and produces a lipooligosaccharide (LOS) containing a terminal sialyl N-acetyllactosamine trisaccharide.
Pfam PF23491: SunI-like bacterial PH domain (domain)
This family includes the B subtilis proteins YnzG and SunI. SunI is the sublancin immunity protein. Members of this family are bacterial PH domains.
Pfam PF00921: Borrelia lipoprotein (family)
This family of lipoproteins is found in Borrelia spirochetes. The function of these proteins is uncertain.
Pfam PF21702: GLGE, C-terminal (domain)
This entry represents the C-terminal domain of alpha-1,4-glucan:maltose-1-phosphate maltosyltransferases (GLGE) which has an all-beta fold. This domain, referred to domain C, together with the catalytic one, is involved in the binding of alpha-glucan chains.
Pfam PF03626: Prokaryotic Cytochrome C oxidase subunit IV (family)
Cytochrome c oxidase (COX) is a multi-subunit enzyme complex that catalyses the final step of electron transfer through the respiratory chain on the mitochondrial inner membrane. This family is composed of cytochrome c oxidase subunit 4 from prokaryotes.
Wikipedia: The enzyme cytochrome c oxidase or Complex IV is a large transmembrane protein complex found in bacteria, archaea, and the mitochondria of eukaryotes.
Pfam PF22158: MHC class I-like protein M157, N-terminal domain (domain)
This domain is found in the putative immunoevasin 157, which is important in modulating the response of the host to Mouse cytomegalovirus (MCMV) infection. It shows an MHC-I-like fold.
Pfam PF16231: Domain of unknown function (DUF4890) (family)
This family consists of uncharacterized proteins around 200 residues in length and is mainly found in various Bacteroides species. The function of this family is unknown.
Pfam PF20695: 3-octaprenyl-4-hydroxybenzoate carboxy-lyase N-terminal domain (domain)
This family has been characterised as 3-octaprenyl-4- hydroxybenzoate carboxy-lyase enzymes. This enzyme catalyses the third reaction in ubiquinone biosynthesis. For optimal activity the carboxy-lase was shown to require Mn2+. This entry represents the N-terminal domain.
Wikipedia: In molecular biology this protein domain, refers to UbiD, which is found in prokaryotes, archaea and fungi, with two members in Archaeoglobus fulgidus. They are related to UbiD, a 3-octaprenyl-4-hydroxybenzoate carboxy-lyase from Escherichia coli that is involved in ubiquinone biosynthesis. The member from Helicobacter pylori has a C-terminal extension of just over 100 residues that is shared, in part, by the Aquifex aeolicus homologue.
Pfam PF14909: Spermatogenesis-assoc protein 6 (family)
This domain family is found in eukaryotes, and is approximately 140 amino acids in length. The family has similarity to the motor domain of kinesin related proteins and with the Caenorhabditis elegans neural calcium sensor protein (NCS-2).
Pfam PF17408: Malonyl-CoA decarboxylase N-terminal domain (domain)
This family consists of several eukaryotic malonyl-CoA decarboxylase (MLYCD) proteins. Malonyl-CoA, in addition to being an intermediate in the de novo synthesis of fatty acids, is an inhibitor of carnitine palmitoyltransferase I, the enzyme that regulates the transfer of long-chain fatty acyl-CoA into mitochondria, where they are oxidised. After exercise, malonyl-CoA decarboxylase participates with acetyl-CoA carboxylase in regulating the concentration of malonyl-CoA in liver and adipose tissue, as well as in muscle. Malonyl-CoA decarboxylase is regulated by AMP-activated protein kinase (AMPK).
Pfam PF01878: EVE domain (domain)
This domain was formerly known as DUF55.  Crystal structures have shown that this domain is part of the PUA superfamily. This domain has been named EVE and is thought to be RNA-binding.
Pfam PF17384: RimP C-terminal SH3 domain (domain)
This family represents the C-terminal domain from RimP.
Pfam PF02815: MIR domain (domain)
The MIR (protein mannosyltransferase, IP3R and RyR) domain is a domain that may have a ligand transferase function.
Pfam PF10764: Inhibitor of sigma-G Gin (family)
Gin allows sigma-F to delay late forespore transcription by preventing sigma-G to take over before the cell has reached a critical stage of development. Gin is also known as CsfB.
Pfam PF05868: Rotavirus major outer capsid protein VP7 (family)
This family consists of several Rotavirus major outer capsid protein VP7 sequences. The rotavirus capsid is composed of three concentric protein layers. Proteins VP4 and VP7 comprise the outer layer. VP4 forms spikes and is the viral attachment protein. VP7 is a glycoprotein and the major constituent of the outer protein layer.
Pfam PF18616: CDI immunity proteins (domain)
Contact-dependent growth inhibition (CDI) is a widespread mechanism of bacterial competition. CDI+ bacteria deliver the toxic C-terminal region of contact-dependent inhibition A proteins (CdiA-CT) into neighboring target bacteria and produce CDI immunity proteins (CdiI) which bind CdiA-CT domains and neutralize their toxic activity to protect against self-inhibition. CdiI immunity proteins are also variable and only neutralize their cognate CdiA-CT toxins. Structure analysis of CdiI from Escherichia coli 536 (EC536) shows that is composed of a single domain and that it blocks the interaction with substrate, strongly suggesting that the immunity protein occludes the nuclease active site.
Pfam PF25053: Domain of unknown function (DUF7791) (domain)
This domain is found in a group of uncharacterised fungal proteins that also contain the domain [pfam:PF24883] at its N-terminal end. This domain is predicted to have a mainly alpha helical configuration.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF07215: Protein of unknown function (DUF1419) (family)
This family consists of several bacterial proteins of around 110 residues in length. Members of this family seem to be specific to Agrobacterium species and to Rhizobium loti. The function of this family is unknown.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF01781: Ribosomal L38e protein family (family)
Ribosomal protein eL38 forms part of the 60S ribosomal subunit . This family is found in eukaryotes.
Ribosomes are the particles that catalyse mRNA-directed protein synthesis in all organisms. The codons of the mRNA are exposed on the ribosome to allow tRNA binding. This leads to the incorporation of amino acids into the growing polypeptide chain in accordance with the genetic information. Incoming amino acid monomers enter the ribosomal A site in the form of aminoacyl-tRNAs complexed with elongation factor Tu (EF-Tu) and GTP. The growing polypeptide chain, situated in the P site as peptidyl-tRNA, is then transferred to aminoacyl-tRNA and the new peptidyl-tRNA, extended by one residue, is translocated to the P site with the aid the elongation factor G (EF-G) and GTP as the deacylated tRNA is released from the ribosome through one or more exit sites . About 2/3 of the mass of the ribosome consists of RNA and 1/3 of protein. The proteins are named in accordance with the subunit of the ribosome which they belong to the small (S1 to S31) and the large (L1 to L44). Usually they decorate the rRNA cores of the subunits.

Many ribosomal proteins, particularly those of the large subunit, are composed of a globular, surfaced-exposed domain with long finger-like projections that extend into the rRNA core to stabilise its structure. Most of the proteins interact with multiple RNA elements, often from different domains. In the large subunit, about 1/3 of the 23S rRNA nucleotides are at least in van der Waal's contact with protein, and L22 interacts with all six domains of the 23S rRNA. Proteins S4 and S7, which initiate assembly of the 16S rRNA, are located at junctions of five and four RNA helices, respectively. In this way proteins serve to organise and stabilise the rRNA tertiary structure. While the crucial activities of decoding and peptide transfer are RNA based, proteins play an active role in functions that may have evolved to streamline the process of protein synthesis. In addition to their function in the ribosome, many ribosomal proteins have some function 'outside' the ribosome .
Pfam PF19798: Sulfotransferase domain (domain)
This entry represents a family of sulfotransferase enzymes. This family of proteins is found in bacteria and eukaryotes. Proteins in this family are typically between 238 and 379 amino acids in length.
Pfam PF01426: BAH domain (domain)
This domain has been called BAH (Bromo adjacent homology) domain and has also been called ELM1 and BAM (Bromo adjacent motif) domain. The function of this domain is unknown but may be involved in protein-protein interaction.
Wikipedia: In molecular biology, the BAH domain domain is found in proteins such as eukaryotic DNA (cytosine-5) methyltransferases, the origin recognition complex 1 (Orc1) proteins, Bromo adjacent homology domain containing 1 (BAHD1), as well as several proteins involved in transcriptional regulation. The BAH domain appears to act as a protein-protein interaction module specialised in gene silencing, as suggested for example by its interaction within yeast Orc1p with the silent information regulator Sir1p. The BAH domain might therefore play an important role by linking DNA methylation, replication and transcriptional regulation.
Pfam PF20474: PHL domain (domain)
This presumed domain is found in the PHL protein [swissprot:F4IDB2].
Pfam PF15582: Immunity protein 65 (family)
A predicted immunity protein with an alpha+beta fold and a conserved YxC motif. Proteins containing this domain are present in bacterial polymorphic toxin systems as an immediate gene neighbour of the toxin gene, which usually contains toxin domains of the Tox-JAB1 family. The immunity protein typically contains a signal peptide and a lipobox.
Pfam PF11378: Protein of unknown function (DUF3181) (family)
This family of proteins has no known function.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF14784: C-terminal domain of the ECSIT protein (domain)
This family represents the C-terminal domain of the evolutionarily conserved signaling intermediate in Toll pathway protein, an adapter protein of the Toll-like and IL-1 receptor signaling pathway, which is involved in the activation of NF-kappa-B via MAP3K1. This domain is missing in isoform 2. Fold recognition suggests that this domain may be distantly homologous to the pleckstrin homology domain
Pfam PF15514: Restriction endonuclease ThaI (domain)
This family of restriction endonucleases belongs to the PD-(D/E)XK superfamily. It cuts the recognition site CG^CG leaving blunt ends.
Pfam PF20668: Domain of unknown function (DUF6815) (domain)
This presumed domain is functionally uncharacterised and is found in bacteria and eukaryotes. It may contain an ATP-grasp-like fold which suggest an ATP-binding function. There are several conserved motifs: EGxxR, PxxWxxDF and ExNCSCV.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF11655: Protein of unknown function (DUF2589) (family)
This family of proteins has no known function.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF18559: Galactose-binding domain-like (domain)
This is the C-terminal domain found in ExoP (exo-1,3/1,4-beta-glucanase) from Pseudoalteromonas. This domain contains a beta-sandwich fold which is common in glycosyl hydrolases (GH7, 11, 12 and 16) and in some 23 carbohydrate-binding modules. It is suggested that the main role of this domain is to provide structural stability necessary for ExoP activity, however no substrate-binding role has been shown.
Pfam PF24201: Domain of unknown function (DUF7426) (domain)
This entry represents an uncharacterised domain found in phage proteins.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF05911: Filament-like plant protein, long coiled-coil (coiled_coil)
FPP is a family of long coiled-coil plant proteins that are filament-like. It interacts with the nuclear envelope-associated protein, MAF1, the WPP family [pfam:PF13943].
Pfam PF12721: RIP homotypic interaction motif (conserved_site)
RIP proteins are receptor-interacting serine/threonine-protein kinases or cell death proteins. This interacting domain is involved in virus recognition. The RHIM domain is necessary for the recruitment of RIP and RIP3 by the IFN-inducible protein DNA-dependent activator of IRFs (DAI), also known as DLM-1 or Z-DNA binding protein (ZBP1). Both the RIP kinases contribute to DAI-induced NF-kappaB activation. RIP3 undergoes auto phosphorylation on binding to DAI.
Pfam PF08312: cwf21 domain (domain)
The cwf21 family is involved in mRNA splicing.  It has been isolated as a subcomplex of the splicosome in Schizosaccharomyces pombe. The function of the cwf21 domain is to bind directly to the spliceosomal protein Prp8. Mutations in the cwf21 domain prevent Prp8 from binding. The structure of this domain has recently been solved which shows this domain to be composed of two alpha helices.
Pfam PF16413: DNA mismatch repair protein Mlh1 C-terminus (domain)
This is the C-terminal domain of DNA mismatch repair protein Mlh1, these proteins belong to the MutL family. This domain forms part of the endonuclease active site.
Pfam PF18803: CxC2 like cysteine cluster associated with KDZ transposases (domain)
A predicted Zinc chelating domain present N-terminal to the KDZ transposase domain.
Pfam PF21891: Family of unknown function (DUF6917) (domain)
This family of proteins is found in bacteria. Proteins in this family are typically between 135 and 154 amino acids in length. These proteins share significant sequence similarity to the central part of mammalian cell entry (MCE) protein MlaD.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF18411: Annexin-like domain (domain)
This annexin-like domain can be found in astrotactin 2 (Astn-2), an integral membrane perforin-like protein linked to the planar cell polarity pathway in hair cells. The annexin-like domain is closest in fold to repeat three of human annexin V and similarly binds calcium, yet shares no sequence homology with it. Notably, this ASTN-2 annexin-like domain is closer in structure to human annexin repeat 3 than human annexin repeat 3 is to repeat 1. Annexin-like domains are known for their capacity to remodel membranes, triggered by calcium binding, and have also been suggested to be involved in the formation of pores in membranes both are possible biological roles of the ASTN-2 annexin-like domain.
Pfam PF08822: Protein of unknown function (DUF1804) (family)
This family of bacterial protein is uncharacterised.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF21614: Domain of unknown function (DUF6854) (domain)
This domain is found usually twice in a group of uncharacterised bacterial proteins. It shows a four-stranded beta-sheet and two alpha-helices.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF10735: Protein of unknown function (DUF2526) (family)
This family of proteins with unknown function is restricted to Enterobacteriaceae. The family has a highly conserved sequence.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF02253: Phospholipase A1 (domain)
Phospholipase A1 is a bacterial outer membrane bound acyl hydrolase with a broad substrate specificity [ec:3.1.1.32]. It has been proposed  that Ser164 is the active site for [swissprot:P00631].
Wikipedia: Outer membrane phospholipase A1 (OMPLA)  is an acyl hydrolase with a broad substrate specificity (EC:3.1.1.32.) from the bacterial outer membrane. It has been proposed that Ser164 is the active site of the protein
Pfam PF19896: Family of unknown function (DUF6369) (family)
This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0000728) is described by MIBiG as an example of the following biosynthetic class, saccharide, in particular the capsular polysaccharide biosynthetic gene cluster from Klebsiella  pneumoniae subsp. ozaenae.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF04535: Casparian strip membrane protein domain (domain)
This domain is found mainly in plant proteins known as Casparian strip membrane proteins (CASPs) and CASP-like proteins (CASPLs). CASPs are four-membrane-span proteins that mediate the deposition of Casparian strips in the endodermis by recruiting the lignin polymerization machinery. Interestingly, the CASP first extracellular loop was found conserved in euphyllophytes but absent in plants lacking Casparian strips.
Pfam PF20987: Intron-encoded endonuclease 1, DNA-binding domain (domain)
This domain is found in Intron-encoded endonuclease 1 (I-TevI) from Bacteriophage T4. I-TevI is a site-specific endonuclease that belongs to the GIY-YIG family that shows a catalytic domain ([pfam:PF01541]) and a DNA-binding domain (this entry), which is organised into three DNA recognition subdomains: a Zn finger, an elongated subdomain that includes a minor groove-binding alpha- helix and a helix-turn-helix subdomain.
Pfam PF00732: GMC oxidoreductase (domain)
This family of proteins bind FAD as a cofactor.
Wikipedia: In molecular biology, the glucose-methanol-choline oxidoreductase family is a family of enzymes with oxidoreductase activity.
Pfam PF21144: Intron-binding protein aquarius insert domain (domain)
This entry represents the insert domain of intron-binding protein aquarius, a splicing factor which links excision of introns from pre-mRNA with snoRP assembly.