SII-SWORD/CoKE huggingface dataset:
Pfam PF10976: Protein of unknown function (DUF2790) (family)
This family of proteins with unknown function appear to be restricted to Pseudomonadaceae.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF24897: Domain of unknown function (DUF7744) (domain)
This entry represents the C-terminal domain of a small set of proteins belonging to the [pfam:PF04465]. Structure prediction suggests that this domain may mediate dimerisation.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF16869: Condensin II complex subunit CAP-H2 or CNDH2, mid domain (family)
CNDH2_M is the middle domain of the H2 subunit of the condensin II complex, found in eukaryotes but not fungi. Eukaryotes carry at least two condensin complexes, I and II, each made up of five subunits.  The functions of the two complexes are collaborative but non-overlapping. CI appears to be functional in G2 phase in the cytoplasm beginning the process of chromosomal lateral compaction while the CII are concentrated in the nucleus, possibly to counteract the activity of cohesion at this stage. In prophase, CII contributes to axial shortening of chromatids while CI continues to bring about lateral chromatid compaction, during which time the sister chromatids are joined centrally by cohesins. There appears to be just one condensin complex in fungi.  CI and CII each contain SMC2 and SMC4 (structural maintenance of chromosomes) subunits, then CI has non-SMC CAP-D2 (CND1), CAP-G (CND3), and CAP-H (CND2). CII has, in addition to the two SMCs, CAP-D3, CAPG2 and CAP-H2.  All four of the CAP-D and CAP-G subunits have degenerate HEAT repeats, whereas the CAP-H are kleisins or SMC-interacting proteins (ie they bind directly to the SMC subunits in the complex).  The SMC molecules are each long with a small hinge-like knob at the free end of a longish strand, articulating with each other at the hinge. Each strand ends in a knob-like head that binds to one or other end of the CAP-H subunit.  The HEAT-repeat containing D and G subunits bind side-by-side between the ends of the H subunit. Activity of the various parts of the complex seem to be triggered by extensive phosphorylations, eg, entry of the complex, in Sch.pombe, into the nucleus during mitosis is promoted by Cdk1 phosphorylation of SMC4/Cut3; and it has been shown that Cdk1 phosphorylates CAP-D3 at Thr1415 in He-La cells thus promoting early stage chromosomal condensation by CII. This region represents the disordered section of CNDH2 between the N- and the C-termini.
Pfam PF23897: Family of unknown function (DUF7245) (family)
This entry represents an uncharacterized protein domain found in viral proteins, primarily from Mycobacterium and Gordonia phages. The domain is approximately 120 amino acids in length. These proteins are composed of a small N-terminal zinc binding domain connected by an alpha helix to a small beta barrel domain at the C-terminus.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF18688: Family of unknown function (DUF5638) (domain)
This is a domain of unknown function found in Legionella.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF23367: Family of unknown function (DUF7091) (family)
This family represents a group of proteins from halobacteria. It has a conserved motif VCRRH/YAE and conserved R, Y and W residues. Members are predicted to show an alpha-beta configuration.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF01875: Memo-like protein (family)
This family contains members from all branches of life.  The molecular function of this protein is unknown, but Memo (mediator of ErbB2-driven cell motility) a human protein is included in this family. It has been suggested that Memo controls cell migration by relaying extracellular chemotactic signals to the microtubule cytoskeleton.
Pfam PF15889: Domain of unknown function (DUF4738) (family)
Family of uncharacterized proteins found in CFB group of bacteria, mostly from Bacteroides and Prevotella  genera present in human gut and oral cavity, respectively.  JCSG target SP13584B, the  experimentally determined structure consists of two WD40-like  beta sheet repeats forming a beta sandwich
Pfam PF11554: Protein of unknown function (DUF3232) (family)
This bacterial family of proteins has no known function.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF21907: CEP-1 C-terminal SAM domain (domain)
This entry represents the C-terminal domain of the CEP-1 protein which is a p53 homologue found in C. elegans. The CEP-1 C-terminus is composed of two sub-domains, an oligomerisation domain (OD) followed by a SAM domain (this entry) that closely interacts with the oligomerisation. The OD domain of CEP-1 forms a dimer instead of the usual tetramer observed in human p53.
Pfam PF09866: Uncharacterized protein conserved in bacteria (DUF2093) (family)
This domain, found in various hypothetical prokaryotic proteins, has no known function.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF06854: Bacteriophage Gp15 protein (family)
This family consists of bacteriophage Gp15 proteins and related bacterial sequences. The function of this family is unknown
Pfam PF06688: Protein of unknown function (DUF1187) (family)
This family consists of several short, hypothetical bacterial proteins of around 62 residues in length. Members of this family are found in Escherichia coli and Salmonella typhi. The function of this family is unknown.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF17990: L-Lysine epsilon oxidase N-terminal (domain)
This is the N-terminal domain found in antimicrobial protein (LodA) with lysine-epsilon oxidase activity (EC 1.4.3.20) which is produced by gram-negative marine bacteria such as Marinomonas mediterranea. The enzyme, previously named marinocine, catalyzes the oxidative deamination of l-lysine into 6-semialdehyde 2-aminoadipic acid, ammonia, and hydrogen peroxide (H2O2). Orthologous proteins have been detected in other bacterial genera, where they participate in biofilm development and dispersal. It has been shown that M. mediterranea LodA and its homologues induce cell death in the microcolonies formed in the process of biofilm development due to the hydrogen peroxide generated by their enzymatic activity. Moreover, cells dispersed from the biofilm by means of this mechanism show a phenotypic variation in growth and biofilm formation. The active form of LodA containing the quinonic cofactor is generated intracellularly only in the presence of LodB, suggesting that the latter protein is involved in this process.
Pfam PF09094: Alpha-amylase/4-alpha-glucanotransferase, middle domain (domain)
This entry represents a domain found in prokaryotic alpha-amylase and 4-alpha-glucanotransferase. It is adjacent to the C-terminal domain ([pfam:PF09095]). This domain adopts an immunoglobulin/ albumin-binding domain-like fold, with a bundle of three alpha-helices. Their function is, as yet, unknown.
Pfam PF14668: Rapamycin-insensitive companion of mTOR, domain 5 (domain)
Rictor appears to serve as a scaffolding protein that is important for maintaining mTORC2 integrity. The mammalian target of rapamycin (mTOR) is a conserved Ser/Thr kinase that forms two functionally distinct complexes, mTROC1 and mTORC2, important for nutrient and growth-factor signalling. These long eukaryotic proteins carry several well-conserved domains, and this is No.5.
Pfam PF00713: Hirudin (domain)
The hirudin family are proteinase inhibitors that belong to MEROPS inhibitor family I14, clan IM. Hirudin is a potent thrombin inhibitor secreted by the salivary glands of the Hirudinaria manillensis (Buffalo leech) and Hirudo medicinalis (Medicinal leech) . It forms a stable non-covalent complex with alpha-thrombin, thereby abolishing its ability to cleave fibrinogen.
Pfam PF12789: Phage tail repeat like (repeat)
This family largely contains proteins from the eukaryote Trichomonas vaginalis.  These proteins contain multiple HXH repeats. Some proteins in this family are annotated as having phage tail repeats. The function of this family is unknown.
Pfam PF16018: Anillin N-terminus (family)
This domain is found towards the N-terminus of anillin. In mammalian anillin this domain is repeated. This domain overlaps with the region responsible for nuclear localisation of anillin.
Wikipedia: Anillin is a conserved protein implicated in cytoskeletal dynamics during cellularization and cytokinesis. The ANLN gene in humans and the scraps gene in Drosophila encode Anillin. In 1989, anillin was first isolated in embryos of Drosophila melanogaster. It was identified as an F-actin binding protein. Six years later, the anillin gene was cloned from cDNA originating from a Drosophila ovary. Staining with anti-anillin antibody showed the anillin localizes to the nucleus during interphase and to the contractile ring during cytokinesis. These observations agree with further research that found anillin in high concentrations near the cleavage furrow coinciding with RhoA, a key regulator of contractile ring formation.
Pfam PF06589: Circumsporozoite-related antigen (CRA) (family)
This family consists of several circumsporozoite-related antigen (CRA) or exported protein-1 (EXP1) sequences found specifically in Plasmodium species. The function of this family is unknown.
Pfam PF08030: Ferric reductase NAD binding domain (domain)
This entry contains ferric reductase NAD binding proteins.
Pfam PF23765: Paramyxoviridae matrix protein C-terminal domain (domain)
This entry represents the C-terminal domain found in a variety of paramyxoviruses such as Morbillivirus, paramyxovirus, pneumovirus M proteins. The C-terminal domain of the NDV matrix protein consists of residues 198-364. Similar to the N-terminal domain, it adopts a beta-sandwich fold with beta-strands in the opposing beta-sheets arranged approximately orthogonal to each other. The C-terminal domain is also decorated with several surface-exposed alpha-helices. It is connected to the N-terminal domain by a 16 amino acid linker. The C-terminal domain contributes to the formation of the physiologically relevant matrix protein dimer, with the two domains related by an approximate fourfold rotation axis aligned with the dimer twofold axis. Key residues in helix alpha9 of the C-terminal domain participate in hydrogen bonding and electrostatic interactions across the dimer interface. The C-terminal domain also contains a positively charged surface that faces the viral membrane, facilitating association with the negatively charged membrane.
Wikipedia: Viral matrix proteins are structural proteins linking the viral envelope with the virus core. They play a crucial role in virus assembly, and interact with the RNP complex as well as with the viral membrane. They are found in many enveloped viruses including paramyxoviruses, orthomyxoviruses, herpesviruses, retroviruses, filoviruses and other groups.
Pfam PF20767: Domain of unknown function (DUF6839) (domain)
This entry represents a domain of unknown function found in a range of bacteria and phage.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF05160: DSS1/SEM1 family (family)
This family contains the breast cancer tumour suppressor BRCA2-interacting protein DSS1 and its homologue SEM1, both of which are short acidic proteins.  DSS1 has been shown to be a conserved component of the Rae1 mediated mRNA export pathway in Schizosaccharomyces pombe.
Wikipedia: In molecular biology, the DSS1/SEM1 protein family is a family of short acidic proteins which includes the 26S proteasome complex subunits SEM1 from Saccharomyces cerevisiae and Drosophila and DSS1 (SHFM1) in mammals. In Saccharomyces cerevisiae, SEM1 is a regulator of both exocyst function and pseudohyphal differentiation. Loss of DSS1 in Homo sapiens (human) has been associated with split hand/split foot malformations.
DSS1 is playing role as a modifier in a novel protein posttranslational modification, referred to as DSSylation, which is probably targeting oxidized proteins and guiding them to proteasomal degradation.
Pfam PF12591: Protein of unknown function (DUF3762) (family)
This domain family is found in viruses, and is approximately 80 amino acids in length. The family is found in association with [pfam:PF05533].
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF19568: Sporulation stage III, protein AA (family)
This entry represents the AAA+ ATPase domain found in Sporulation stage III protein AA from Bacillus subtilis.
The AAA+ superfamily of ATPases is found in all kingdoms of living organisms where they participate in diverse cellular processes including membrane fusion, proteolysis and DNA replication. Although the terms AAA+ and AAA are often used loosely and interchangeably, the classical AAA family members are distinguished by their possession of the SRH region in the AAA module. Many AAA+ proteins are involved in similar processes to those of AAA proteins (facilitation of protein folding and unfolding, assembly or disassembly of proteins complexes, protein transport and degradation), but others function in replication, recombination, repair and transcription. For a review see .
Pfam PF01267: F-actin capping protein alpha subunit (family)
The F-actin capping protein binds in a calcium-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike gelsolin and severin this protein does not sever actin filaments. The F-actin capping protein is a heterodimer composed of two unrelated subunits: alpha and beta (see IPR001698). Neither of the subunits shows sequence similarity to other filament-capping proteins .

This entry represent the alpha subunit (CAPZA), which is a protein of about 268 to 286 amino acid residues whose sequence is well conserved in eukaryotic species . In Drosophila mutations in the alpha and beta subunits cause actin accumulation and subsequent retinal degeneration . In humans CAPZA is part of the WASH complex that controls the fission of endosomes .
Wikipedia: In molecular biology, the F-actin capping protein is a protein complex which binds in a calcium-independent manner to the fast-growing ends of actin filaments, thereby blocking the exchange of subunits at these ends. Unlike gelsolin and severin this protein does not sever actin filaments. The F-actin capping protein is a heterodimer composed of two unrelated subunits: alpha and beta. Neither of the subunits shows sequence similarity to other filament-capping proteins. The alpha subunit is a protein of about 268 to 286 amino acid residues and the beta subunit is approximately 280 amino acids, their sequences are well conserved in eukaryotic species.
Pfam PF24924: Domain of unknown function (DUF7745) (domain)
This domain is found in uncharacterised proteins mainly from plants. It has detectable similarity to plant mobile domains and it is predicted to adopt similar structure.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF00361: NADH:quinone oxidoreductase/Mrp antiporter, TM (domain)
This entry includes membrane transporters and represents some 7 of potentially 14-16 TM regions. In many instances, its members forms part of complex I that catalyses the transfer of two electrons from NADH to ubiquinone in a reaction that is associated with proton translocation across the membrane, and in this context is a combination predominantly of subunits 2, 4, 5, 14, L, M and N. In many bacterial species these proteins are probable stand-alone transporters not coupled with oxidoreduction.
Wikipedia: A membrane transport protein is a membrane protein involved in the movement of ions, small molecules, and macromolecules, such as another protein, across a biological membrane. Transport proteins are integral transmembrane proteins; that is they exist permanently within and span the membrane across which they transport substances. The proteins may assist in the movement of substances by facilitated diffusion, active transport, osmosis, or reverse diffusion. The two main types of proteins involved in such transport are broadly categorized as either channels or carriers. Examples of channel/carrier proteins include the GLUT 1 uniporter, sodium channels, and potassium channels. The solute carriers and atypical SLCs are secondary active or facilitative transporters in humans. Collectively membrane transporters and channels are known as the transportome. Transportomes govern cellular influx and efflux of not only ions and nutrients but drugs as well.
Pfam PF19017: Domain of unknown function (DUF5746) (domain)
This is a highly conserved domain found in various Platyhelminthes. Its function is currently unknown, with some of the sequences annotated as being Palmitoyltransferase. This highly conserved domain is located at the amino terminus, next to a DHHC domain (named for its signature tetrapeptide Asp-His-His-Cys).
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF15399: Domain of unknown function (DUF4620) (family)
This entry represents a protein family of unknown function from primates.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF24906: WRKY19 zinc finger domain (domain)
This entry represents a small zinc finger domain found in the WRKY19 protein. Structure prediction suggests that this protein has an array of these domains that wrap around the major groove of DNA.  The WRKY transcription factor 19 family includes proteins that function as transcription factors, specifically interacting with the W box, a common elicitor-responsive cis-acting element. Additionally, these proteins may also act as disease resistance proteins with serine/threonine-protein kinase activity.
Pfam PF02669: K+-transporting ATPase, c chain (family)
This family consists of K+-transporting ATPase, c chain, KdpC. KdpC forms strong interactions with the KdpA subunit, serving to assemble and stabilise the Kdp complex.  It has been suggested that KdpC could be one of the connecting links between the energy providing subunit KdpB and the K+-transporting subunit KdpA.  The K+ transport system actively transports K+ ions via ATP hydrolysis.
Pfam PF24428: PYCO1 Rubisco-binding repeat (conserved_site)
This entry represents a repeat found in the pyrenoid component 1 (PYCO1) protein from diatoms. PYCO1 is an intrinsically disordered repeat protein that plays a crucial role in the formation of the pyrenoid, a microcompartment within chloroplasts that concentrates CO2 for more efficient carbon fixation. This entry represents a repeat that binds to the Rubisco small subunit. Four KWSPR/Q motifs can form a tetrad that binds to the small subunits lining Rubisco's central solvent channel.  The repeats enable PYCO1 to undergo liquid-liquid phase separation, forming condensates that specifically partition diatom Rubisco. This phase separation is crucial for the formation and function of the pyrenoid in diatoms, which are responsible for a significant portion of marine carbon fixation.