SII-SWORD/CoKE huggingface dataset:
Pfam PF07765: KIP1-like protein (family)
This is a family of sequences found exclusively  in plants. They are similar to kinase interacting protein 1 (KIP1), which has been found to interact with the kinase domain of PRK1, a receptor-like  kinase. This particular region contains two coiled-coils, which are described as motifs involved in protein-protein interactions. It has also been suggested that the protein's coiled- coils allow it to dimerise in vivo.
Pfam PF18516: RuvC nuclease domain (domain)
This is a RuvC nuclease domain found in type V CRISPR-associated protein Cas12a (Cpf1), used for genome editing applications. These proteins carry out endoribonuclease activity for processing its own guide RNAs and RNA-guided DNase activity for target DNA cleavage. The C-terminal region of Cas12a carries the RUVC domain, NUC domain [pfam:PF18510] and the arginine-rich bridge helix (BH). Both the NUC and BH domains are nested in the RuvC domain. Mutations in the RuvC domain impair cleavage of both strands in a target DNA duplex, while a mutation in the Nuc domain impaired target strand cleavage only.  This indicates that the DNA nuclease active sites are located at the interface of the RuvC and Nuc domains and that cleavage of the non-target DNA strand by the RuvC domain is a prerequisite for target strand cleavage by the Nuc domain.
Pfam PF09835: Uncharacterized protein conserved in bacteria (DUF2062) (family)
This domain, found in various prokaryotic proteins, has no known function.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF00882: Zinc dependent phospholipase C (domain)
This domain is found in bacterial zinc-dependent phospholipase C and in eukaryotic phosphatidylinositol-glycan-specific phospholipase D.

Bacterial phospholipase C is a zinc-dependent enzyme, binding 3 zinc ions per molecule . This enzyme catalyses the conversion of phosphatidylcholine and water to 1,2-diacylglycerol and choline phosphate. Phosphatidylinositol-glycan-specific phospholipase D is an extracellular amphiphilic glycoprotein . It hydrolyses the inositol phosphate linkage in proteins anchored by phosphatidylinositol glycans, releasing these proteins from the membrane.
Wikipedia: In molecular biology, zinc-dependent phospholipases C  is a family of bacterial phospholipases C enzymes, some of which are also known as alpha toxins.
Pfam PF09568: MjaI restriction endonuclease (family)
This family includes the MjaI (recognises CTAG but cleavage site unknown) restriction endonuclease.
Pfam PF17386: Lacto-N-biose phosphorylase C-terminal domain (domain)
The gene which codes for this protein in gut-bacteria is located in a novel putative operon for galactose metabolism. The protein appears to be a carbohydrate-processing phosphorolytic enzyme ([ec:2.4.1.211]), unlike either glycoside hydrolases or glycoside lyase. Intestinal colonisation by bifidobacteria is important for human health, especially in pediatrics, because colonisation seems to prevent infection by some pathogenic bacteria that cause diarrhoea or other illnesses. The operon seems to be involved in intestinal colonisation by bifidobacteria mediated by metabolism of mucin sugars. In addition, it may also resolve the question of the nature of the bifidus factor in human milk as the lacto-N-biose structure found in milk oligosaccharides.
Pfam PF04290: Tripartite ATP-independent periplasmic transporters, DctQ component (domain)
This entry includes tripartite ATP-independent periplasmic (TRAP) transporters which are substrate-binding protein (SBP)-dependent secondary transporters ubiquitous prokaryotes. They are comprised of an SBP of the DctP or TAXI families and two integral membrane proteins of unequal sizes that form the DctQ and DctM protein families (the small and large membrane components respectively). This entry represents the DctQ component and its homologues, which consists of five transmembrane segments. In SiaT, a protein involved in sialic acid uptake, this entry represents the N-terminal five transmembrane segments.
Wikipedia: Tripartite ATP-independent periplasmic transporters are a large family of solute transporters found in bacteria and archaea, but not in eukaryotes, that appear to be specific for the uptake of organic acids or related molecules containing a carboxylate or sulfonate group. They are unique in that they utilize a substrate binding protein (SBP) in combination with a secondary transporter.
Pfam PF06592: Protein of unknown function (DUF1138) (family)
This family consists of several hypothetical short plant proteins from Arabidopsis thaliana and Oryza sativa. The function of this family is unknown.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF18285: Tetracycline repressor LuxT C-terminal domain (domain)
This is the C-terminal domain of LuxT. LuxT is a tetracycline repressor family regulator identified in Vibrio alginolyticus which may play a role in the fine-tuning of the virulence via quorum sensing (QS).
Pfam PF16302: Domain of unknown function (DUF4944) (family)
This family consists of uncharacterized proteins around 160 residues in length and is mainly found in various Bacillus species. The function of this family is unknown.
Pfam PF10092: Uncharacterized protein conserved in bacteria (DUF2330) (family)
Members of this family of hypothetical bacterial proteins have no known function.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF08982: Acetylaranotin biosynthesis cluster protein L (family)
This entry includes acetylaranotin biosynthesis cluster protein L (AtaL) from Aspergillus terreus, which is a non-ribosomal peptide synthetase. It is required for the biosynthesis of the toxin acetylaranotin, which is a disulfide bridged cyclic dipeptide. There are a number of steps in the biosyntheis of this epipolythiodioxopiperazine toxin from two phenylananines, but the specific function of AtaL has yet to be determined. Homologues are also known from bacteria.
Pfam PF24325: Domain of unknown function (DUF7495) (domain)
This domain is found in a group of uncharacterised eukaryotic proteins. It contains six highly conserved cysteines which are predicted to form disulfide bonds. This domain is predicted to adopt structure similar to C-type lectins.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF24191: Mycobacteriophage protein with transmembrane helix (family)
This entry represents a family of proteins of unknown function found in mycobacteriophage genomes. The family includes short proteins between 44-60 amino acids in length that contain a single predicted transmembrane helix.  The presence of these proteins in numerous mycobacteriophage genomes suggests they may play a role in phage biology, but their specific function has yet to be determined experimentally.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF08838: Protein of unknown function (DUF1811) (family)
This family includes uncharacterised proteins predominantly found in Firmicutes, including Uncharacterized protein YfhH from Bacillus subtilis and protein GK0453 from Geobacillus kaustophilus. GK0453 shows two small domains: an helix-turn-helix like motif is found in its N-terminal domain while an SH3-like beta-barrel like structure is observed its C-terminal region. Its specific function is unknown. Some of the members of this protein family are annotated as transcriptional regulators (see Q3EXU7, Q81I96).
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF17371: Family of unknown function (DUF5393) (family)
This is a family of unknown function found in Trypanosomatidae.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF22244: Glucuronyl esterase, fungi (domain)
This entry includes fungal glucuronyl esterases, which seems to play a significant role in biomass degradation, as they can disconnect hemicellulose from lignin  through the hydrolysis of the ester bond between 4-O-methyl-D-glucuronic acid residues of glucuronoxylans and aromatic alcohols of lignin. They belong to the carbohydrate esterase family 15 (CE15).
Pfam PF11269: Protein of unknown function (DUF3069) (family)
This family of proteins with unknown function appear to be restricted to Gammaproteobacteria.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF02457: DisA bacterial checkpoint controller nucleotide-binding (family)
The DisA protein is a bacterial checkpoint protein that dimerises into an octameric complex. The protein consists of three distinct domains. This domain is the first and is a globular, nucleotide-binding region; the next 146-289 residues constitute the DisA-linker family, [pfam:PF10635], that consists of an elongated bundle of three alpha helices (alpha-6, alpha-10, and alpha-11), one side of which carries an additional three helices (alpha7-9), which thus forms a spine like-linker between domains 1 and 3. The C-terminal residues, of domain 3, are represented by family HHH, [pfam:PF00633], the specific DNA-binding domain. The octameric complex thus has structurally linked nucleotide-binding and DNA-binding HhH domains and the nucleotide-binding domains are bound to a cyclic di-adenosine phosphate such that DisA is a specific di-adenylate cyclase. This N-terminal domain has been identified as a diadenylate cyclase (DAC) responsible for producing c-di-AMP from two molecules of ATP. The di-adenylate cyclase activity is strongly suppressed by binding to branched DNA, but not to duplex or single-stranded DNA, suggesting a role for DisA as a monitor of the presence of stalled replication forks or recombination intermediates via DNA structure-modulated c-di-AMP synthesis.
Pfam PF17772: MYST family zinc finger domain (domain)
This zinc finger domain is found in the MYST family of histone acetyltransferases.
Pfam PF09090: MIF4G like (repeat)
Members of this family are involved in mediating U snRNA export from the nucleus. They adopt a highly helical structure, wherein the polypeptide chain forms a right-handed solenoid. At the tertiary level, the domain is composed of a superhelical arrangement of successive antiparallel pairs of helices.
Pfam PF07220: Protein of unknown function (DUF1420) (family)
This family consists of several hypothetical putative lipoproteins which seem to be found specifically in the bacterium Leptospira interrogans. Members of this family are typically around 670 resides in length and their function is unknown.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF07445: Primosomal replication protein priC (family)
This family contains the bacterial primosomal replication protein priC. In Escherichia coli, this function in the assembly of the primosome.
Pfam PF11886: Translocase of chloroplast 159/132, membrane anchor domain (family)
This is the membrane-anchor domain of translocase of chloroplast 159, TOC159/132. This domain is present in plants at the C-terminus of the GTPase, AIG1, [pfam:PF04548], and anchors the GTPas region to the outer membrane of the chloroplast. The domain may carry a very C-terminal sequence motif that resembles a transit peptide.
Pfam PF03874: RNA polymerase Rpb4 (family)
This family includes the Rpb4 protein.  This family also includes C17 (aka CGRP-RCP) is an essential subunit of RNA polymerase III. C17 forms a subcomplex with C25 which is likely to be the counterpart of subcomplex Rpb4/7 in Pol II.
Pfam PF04050: Up-frameshift suppressor 2 (repeat)
Transcripts harbouring premature signals for translation termination  are recognised and rapidly degraded by eukaryotic cells through a  pathway known as nonsense-mediated mRNA decay. In Saccharomyces cerevisiae, three trans-acting factors (Upf1 to Upf3)  are required for nonsense-mediated mRNA decay.
Pfam PF10633: NPCBM-associated, NEW3 domain of alpha-galactosidase (domain)
The English-language version of the first reference can be found on pages 388-399 of the above. This domain has been named NEW3 but its actual function is not known. It is found on proteins which are bacterial galactosidases. The domain is associated with the NPCBM family, [pfam:PF08305], a novel putative carbohydrate binding module found at the N-terminus of glycosyl hydrolases.
Pfam PF11314: Protein of unknown function (DUF3117) (family)
This family of proteins with unknown function appears to be restricted to Actinobacteria.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF05622: HOOK protein coiled-coil region (coiled_coil)
This family consists of several HOOK1, 2 and 3 proteins from different eukaryotic organisms. The different members of the human gene family are HOOK1, HOOK2 and HOOK3. Different domains have been identified in the three human HOOK proteins, and it was demonstrated that the highly conserved NH2-domain mediates attachment to microtubules, whereas this central coiled-coil motif mediates homodimerisation and the more divergent C-terminal domains are involved in binding to specific organelles (organelle-binding domains). It has been demonstrated that endogenous HOOK3 binds to Golgi membranes, whereas both HOOK1 and HOOK2 are localised to discrete but unidentified cellular structures. In mice the Hook1 gene is predominantly expressed in the testis. Hook1 function is necessary for the correct positioning of microtubular structures within the haploid germ cell. Disruption of Hook1 function in mice causes abnormal sperm head shape and fragile attachment of the flagellum to the sperm head. This entry includes the central coiled-coiled domain and the divergent C-terminal domain.
Wikipedia: HOOK is a family of evolutionarily related proteins. This family consists of several HOOK1, 2 and 3 proteins from different eukaryotic organisms. The different members of the human gene family are HOOK1, HOOK2 and HOOK3. Different domains have been identified in the three human HOOK proteins, and it was demonstrated that the highly conserved N-terminal domain mediates attachment to microtubules, whereas the central coiled coil motif mediates homodimerisation and the more divergent C-terminal domains are involved in binding to specific organelles. It has been demonstrated that endogenous HOOK3 binds to Golgi membranes, whereas both HOOK1 and HOOK2 are localised to discrete but unidentified cellular structures. In mice the Hook1 gene is predominantly expressed in the testis. Hook1 function is necessary for the correct positioning of microtubular structures within the haploid germ cell. Disruption of Hook1 function in mice causes abnormal sperm head shape and fragile attachment of the flagellum to the sperm head.
Pfam PF23063: M02D8_5-like, fourth CUB domain (domain)
This entry represents the fourth occurrence of the CUB domain in a family of uncharacterised proteins present in nematodes. Consecutive repetitions of this domain are common in this protein family. The CUB domain (for complement C1r/C1s, Uegf, Bmp1) is a structural motif of approximately 110 residues found predominantly in extracellular and plasma membrane-associated proteins, many of which undergo developmental regulation. CUB domains appear to be involved in oligomerisation and/or recognition of substrates and binding  partners.
Pfam PF03269: Caenorhabditis protein of unknown function, DUF268 (family)
This family consists of proteins of unknown function found in Caenorhabditis species.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF09648: YycI protein (family)
This domain is exclusively found in YycI proteins in the low GC content Gram positive species. These two domains share the same structural fold with domains two and three of YycH [pfam:PF07435]. Both, YycH and YycI are always found in pair on the chromosome, downstream of the essential histidine kinase YycG. Additionally, both proteins share a function in regulating the YycG kinase with which they appear to form a ternary complex. Lastly, the two proteins always contain an N-terminal transmembrane helix and are localised to the periplasmic space as shown by PhoA fusion studies.
Pfam PF19437: VCIP135 N-terminal (domain)
Deubiquitinating protein VCIP135 is required for the p97/p47 and p97/p37 pathways during Golgi biogenesis. It reverses ubiquitination events that occurs during mitotic disassembly, regulating Golgi membrane dynamics during mitosis. This entry represents the N-terminal domain of VCIP135 that interacts with the WW domain-containing adaptor with coiled coil (WAC) and increases its deubiquitinating activity, necessary only for p97/p47-mediated Golgi membrane fusion.
Pfam PF05917: Helicobacter pylori protein of unknown function (DUF874) (family)
This family consists of several hypothetical proteins specific to Helicobacter pylori. The function of this family is unknown.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF19784: Family of unknown function (DUF6269) (family)
This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0001975) is described by MIBiG as an example of the following biosynthetic class, NRP (non-ribosomal peptide). It  includes a member from the atratumycin biosynthetic gene cluster  from Streptomyces atratus.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF05296: Taste receptor protein (TAS2R) (family)
This family consists of several forms of eukaryotic taste receptor proteins (TAS2Rs). TAS2Rs are G protein-coupled receptors expressed in subsets of taste receptor cells of the tongue and palate epithelia in humans and mice, and are organised in the genome in clusters. The proteins are genetically linked to loci that influence bitter perception in mice and humans.