SII-SWORD/CoKE huggingface dataset:
Pfam PF23254: PARP14-like, eighth type I KH domain (domain)
This domain is found in human Protein mono-ADP-ribosyltransferase PARP14 and related proteins including mono-ADP-ribosyltransferase PARP9. PARP14 is a large multidomain protein which in the N-terminal half contains a series of consecutive RRM and KH domains that are known to be nucleic acid-binding. In contrast, PARP9 is predicted to contain only a single KH domain. PARP14 is involved in multiple signaling pathways linked to cancer, inflammation, and infection. PARP14 is an ADP-ribosyltransferase that mediates mono-ADP-ribosylation of glutamate residues on target proteins. In contrast to PARP1 and PARP2, it is not able to mediate poly-ADP-ribosylation. PARP9 in association with E3 ligase DTX3L, plays a role in DNA damage repair and in immune responses including interferon-mediated antiviral defenses. It suppresses PARP14-mediated STAT6 ADP-ribosylation. The domain represented by this entry is a KH domain found eighth in the human PARP14.
Pfam PF10713: Protein of unknown function (DUF2509) (family)
This family is conserved in Proteobacteria. The function is not known but many of the members are annotated as protein YgdB.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF21537: DUF1980 C-terminal domain (domain)
Members of this family are found in a set of prokaryotic hypothetical proteins. Their exact function, has not, as yet, been defined. This entry represents the C-terminal domain.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF24563: Mug60/KHD4 KH type I domain (domain)
This is a type I KH domain found in Meiotically up-regulated gene 60 protein (Mug60) from S.pombe and KHD4 from Ustilago maydis. KHD4 is a RNA-binding protein that recognises the sequence AUACCC. It plays an essential role in filamentous growth and virulence. Mug60 plays a role in meiosis.
Pfam PF16927: N-terminal 7TM region of histidine kinase (family)
HisKA_7TM is an N-terminal region consisting of seven transmembrane domains found in Archaea and some bacteria.  It is always found associated with histidine kinase.
Pfam PF23237: HYR-like domain with 4 cysteines (domain)
This domain is found in tandem arrays in bacterial cell surface proteins.  It contains four cysteines that appear to be likely to form two disulphide bridges between adjacent pairs of domains. It seems likely that these domains form rigid stalks. These domains show sequence similarity to HYR domains.
Pfam PF10211: Axonemal dynein light chain (family)
Axonemal dynein light chain proteins play a dynamic role in flagellar and cilia motility. Eukaryotic cilia and flagella are complex organelles consisting of a core structure, the axoneme, which is composed of nine microtubule doublets forming a cylinder that surrounds a pair of central singlet microtubules. This ultra-structural arrangement seems to be one of the most stable micro-tubular assemblies known and is responsible for the flagellar and ciliary movement of a large number of organisms ranging from protozoan to mammals. This light chain interacts directly with the N-terminal half of the heavy chains.
Pfam PF10372: Diadenylate cyclase CdaS, N-terminal (domain)
This entry represents an alpha-hairpin found at the N-terminal of Diadenylate cyclase CdaS. CdaS is one of 3 paralogous diadenylate cyclases (DAC) in Bacillus subtilis and B. thuringiensis, catalysing he condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). It has slow DAC activity with ADP as a substrate and may have weak ADPase activity. CdaS is required for efficient spore formation in B.thuringiensis, whereas in B.subtilis, it is required for efficient spore germination. It is produced under the control of different sigma factors in the two bacteria. It is also required for parasporal crystal formation.
Pfam PF17066: RBPJ-interacting and tubulin associated protein (family)
RITA is a highly conserved protein that binds to tubulin and shuttles between the cytoplasm and nucleus. It is responsible for export of RBP-J/CBF-1 from the nucleus, which modulates Notch-mediated transcription.
Pfam PF22041: Glutathione S-transferase, C-terminal domain (domain)
This domain is found at the C-terminal end of Glutathione transferase (GST) [swissprot:I6ZUH3] from Phanerodontia chrysosporium and similar sequences mainly found in fungi and also in some plant and proteobacterial species. This protein belongs to the "etherase-like" class of fungal cytosolic GSTs. This protein is capable of binding nonsubstrate ligands derived from lignin degradation.
Pfam PF12105: SpoU, rRNA methylase, C-terminal (family)
This domain is found in bacteria. This domain is about 60 amino acids in length. This domain is found in association with [pfam:PF00588]. This domain has a conserved LFE sequence motif. Some members of the Pfam family SpoU_methylase, [pfam:PF00588], carry this very distinctive sequence region at their extreme C-terminus. The exact function of this region is not known.
Pfam PF17073: Two-component-system connector protein (family)
SafA is a bacterial transmembrane protein family that connects the signal transduction between the two component systems EvgS/EvgA and PhoQ/Phop. SafA interacts with PhoQ, leading to the PhoQ/PhoP system activation in response to acid stress conditions.
Pfam PF24652: Centrosomal protein of 76 kDa C-terminal domain (domain)
This entry represents a domain found at the C-terminal of centrosomal protein of 76 kDa, a protein involved in regulation of centriole duplication to limit centriole duplication to once per cell cycle by preventing centriole reduplication. This domain may adopt a fold similar to the CAP domain. This entry also includes CC2D2A/B from human. CCD2A is a component of the tectonic-like complex, a complex localised at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. It is required for ciliogenesis and sonic hedgehog/SHH signalling.
Pfam PF07455: Phage polarity suppression protein (Psu) (family)
This family contains a number of phage polarity suppression proteins (Psu) (approximately 190 residues long). The Psu protein of bacteriophage P4 causes suppression of transcriptional polarity in Escherichia coli by overcoming Rho termination factor activity.
Pfam PF17224: Domain of unknown function (DUF5300) (domain)
This small family of proteins found in Clostridiales is functionally  uncharacterized. Proteins in this family are around 130 amino acids  in length. Based on NMR structure 2MCA, it forms a beta-sandwich  structure consisting of two 4-stranded antiparallel b-strands. The  structure is very similar to glutamine glutamyltransferases (1l9n)  and peptide transporters (5a9h).
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF07099: Protein of unknown function (DUF1361) (family)
This family consists of several hypothetical bacterial proteins of around 200 residues in length. The function of this family is unknown although some members are annotated as being putative integral membrane proteins.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF15296: Codanin-1 C-terminus (family)
This domain is found near to the C-terminus of codanin-1.
Pfam PF14786: Tube Death domain (domain)
This Tube-Death domain has an insertion between helices 2 and 3, and a C-terminal tail compared with the Death domain of Pelle proteins in Drosophila. The two N-terminal Death domains of the serine/threonine kinase Pelle and the adaptor protein Tube interact to form a six-helix bundle fold arranged in an open-ended linear array with plastic interfaces mediating their interactions. This interaction leads to the nuclear translocation of the transcription factor Dorsal and activation of zygotic patterning genes during Drosophila embryogenesis, and is assisted by the significant and indispensable contacts in the heterodimer contributed by the insertion and C-terminal tail described above.
Pfam PF24155: Domain of unknown function (DUF7406) (domain)
This is a small domain found in a group of uncharacterised archaeal sequences. This small domain may have an all-beta fold.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF19937: Gliding motility-associated protein GldC-like (family)
This family of uncharacterised proteins is found in Bacteroidetes. Proteins is these family are likely to be related to the Gliding motility-associated protein GldC, a protein linked to a type of rapid surface gliding motility found in certain Bacteroidetes such as Cytophaga johnsonae (Flavobacterium johnsoniae) and Cytophaga hutchinsonii. Gliding motility appears closely linked to chitin utilisation in the model species C. johnsonae.
Pfam PF17457: Family of unknown function (DUF5420) (family)
This is a domain of unknown function found in Gammaproteobacteria such as Haemophilus influenzae.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF11103: Protein of unknown function (DUF2887) (domain)
This bacterial family of proteins has no known function. These proteins may be distantly related to the PD(D/E)XK superfamily.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF14764: AP-5 complex subunit, vesicle trafficking (repeat)
This family would appear to be the second of the two larger subunits of the fifth Adaptor-Protein complex, AP-5. Adaptor protein (AP) complexes facilitate the trafficking of cargo from one membrane compartment of the cell to another by recruiting other proteins to particular types of vesicles. AP-5 is involved in trafficking proteins from endosomes towards other membranous compartments. There are genetic links between AP-5 and hereditary spastic paraplegia, a group of human genetic disorders characterised by progressive spasticity in the lower limbs.
Pfam PF09564: NgoBV restriction endonuclease (family)
This family includes the NgoBV (recognises GGNNCC but cleavage site is unknown) restriction endonuclease.
Pfam PF23434: Family of unknown function (DUF7120) (family)
This family represents a group of proteins from halobacteria. Members are predicted to adopt an alpha-helical configuration.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF12432: Integrator complex subunit 1, RP2B-binding domain (repeat)
Integrator (INT) complex is involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. It binds the C-terminal domain (CTD) of RNA polymerase II (Pol II) and functions as an RNA endonuclease to cleave different classes of RNAs, regulating the transcription of both protein-coding genes and noncoding elements. Integrator also associates with protein phosphatase 2A (PP2A) core enzyme to form the INTAC complex which regulates transcription through dephosphorylation of Pol II CTD. This entry includes the Integrator complex subunit 1 (INTS1) which forms the backbone module of the complex (it consists of four modules: backbone, shoulder, phosphatase and endonuclease) through the association with INTS2 and INTS7 to form a rigid scaffold. The backbone and shoulder modules form a central cruciform scaffold. INTS1 is an all-alpha helical protein with four repetitive helix hairpin domains towards the C-terminal (R1-R4). This entry represents a domain found at the N-terminal of INTS1, which interacts with Pol II subunit RPB2 and form interface A.
Pfam PF02346: Chordopoxvirus multifunctional envelope protein A27 (family)
This is a family of viral fusion proteins from the chordopoxviruses.  [swissprot:P26312] a 14-kDa Vaccinia Virus protein has been demonstrated to function as a viral fusion protein mediating cell fusion at endosmomal (low) pH.  More recently it has been shown that A27 forms disulfide-linked protein complexes with A26 protein providing an anchor for A26 protein packaging into mature virions. A27 regulates virion-membrane fusion rather than inducing it and is critical for the successful egress of mature virus particles.
Pfam PF15645: Dermonecrotoxin of the Papain-like fold (family)
A papain fold toxin domain found in bacterial polymorphic toxin systems.
Pfam PF23002: ATP-dependent RNA helicase DDX60, PIN-like domain (domain)
This domain is found N-terminal in the homologues of ATP-dependent RNA helicase DDX60 (also known as DEAD-box RNA helicase). This helicase binds ssRNA, dsRNA and dsDNA and can promote the binding of RIGI to dsRNA. DDX60 is non-essential in mammals but it is required for the cell fitness in kinetoplastids and trypanosomatids and plays a specific role in translation initiation in these parasites. In Trypanosoma cruzi, k-DDX60 binds both to the head and the body of the 40S ribosome subunit. It is also involved in the stabilization of the 43S PIC and the remodeling of the 43S PIC mRNA channel. The domain represented by this entry adopts a globular structure with a significant structural similarity to PIN domains.
Pfam PF14494: Domain of unknown function (DUF4436) (family)
This is a family of membrane and transmembrane proteins from mycobacterial and related species. The function is not known.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF24496: Domain of unknown function (DUF7588) (domain)
This domain is found in uncharacterised proteins mainly from plants. It is predicted to adopt an alpha-helical structure consisting of four helices. This domain contains several conserved aromatic hydrophobic residues that may have a functional role.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF02100: Ornithine decarboxylase antizyme (family)
This family consists of ornithine decarboxylase antizyme proteins. The polyamine biosynthetic enzyme ornithine decarboxylase (ODC) is degraded by the 26 S proteasome via a ubiquitin-independent pathway. Its degradation is greatly accelerated by association with the polyamine-induced regulatory protein antizyme 1 (AZ1).
Wikipedia: In molecular biology, Ornithine decarboxylase antizyme (ODC-AZ) is an ornithine decarboxylase inhibitor. It binds to, and destabilises, ornithine decarboxylase (ODC), a key enzyme in polyamine synthesis. ODC is then rapidly degraded. It was first characterized in 1981. The expression of ODC-AZ requires programmed, ribosomal frameshifting which is modulated according to the cellular concentration of polyamines. High levels of polyamines induce a +1 ribosomal frameshift in the translation of mRNA for the antizyme leading to the expression of a full-length protein. At least two forms of ODC-AZ exist in mammals and the protein has been found in Drosophila as well as in Saccharomyces yeast.
Pfam PF10454: Protein of unknown function (DUF2458) (family)
This a is family of uncharacterised proteins.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF11780: Protein of unknown function (DUF3318) (family)
This is a bacterial family of uncharacterised proteins.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF12083: Domain of unknown function (DUF3560) (family)
This presumed domain is functionally uncharacterised. This domain is found in bacteria. This domain is about 120 amino acids in length. This domain has a conserved GHHSE sequence motif.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF20856: SdbC, C-terminal domain (domain)
This domain is found at the C-terminal end of the SdbC protein from Legionella pneumophila, which is thought to be a virulence factor or effector of the pathogen. The structure of the domain is solved, showing a fold mostly consisting of beta-strands.
Pfam PF20000: FtsH ternary system domain X2 (domain)
Uncharacterized domain found in the FtsH ternary system, a class of NTP-dependent biological conflict systems.
Pfam PF13138: Protein of unknown function (DUF3982) (family)
This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 47 and 73 amino acids in length. There are two conserved sequence motifs: EKL and EIP.
Pfam PF13015: Glucosidase II beta subunit-like protein (family)
The sequences found in this family are similar to a region found in the beta-subunit of glucosidase II ([swissprot:P14314]), which is also known as protein kinase C substrate 80K-H (PRKCSH). The enzyme catalyses the sequential removal of two alpha-1,3-linked glucose residues in the second step of N-linked oligosaccharide processing. The beta subunit is required for the solubility and stability of the heterodimeric enzyme, and is involved in retaining the enzyme within the endoplasmic reticulum. The beta-subunit confers substrate specificity for di- and monoglucosylated glycans on the glucose-trimming activity of the alpha-subunit.
Pfam PF21988: Podovirus tailspike protein Galactose-binding domain-like (domain)
This entry represents the Tailspike Galactose-binding domain-like domain, also known as domain 5 (d5) of the tailspike receptor-binding protein (RBP) gp63.1 of bacteriophage G7C. This domain is structurally similar to carbohydrate-binding modules (CBMs) and is involved in substrate binding. Specifically, gp63.1 deacetylates surface polysaccharides of E. coli 4s using the esterase domain located within d5, while other domains mediate the interaction between gp63.1 and gp66 to form a stable complex. CBMs, including d5, are non-catalytic domains found in multidomain polysaccharide depolymerases where they play a role in substrate binding and determine the substrate specificity of the entire enzyme.
Pfam PF19123: Family of unknown function (DUF5807) (family)
This is a family of proteins of unknown function found in Halobacteria.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF10448: 20S proteasome chaperone assembly proteins 3 and 4 (family)
This family contains chaperones of the 20S proteasome which function in early 20S proteasome assembly. The structures of two of the proteins in this family (POC3 and POC4) have been solved, and they closely resemble those of the mammalian proteasome assembling chaperone PAC3, although there is little sequence similarity between them.
Pfam PF16617: Intersectin and clathrin adaptor AP2 binding region (disordered)
INTAP is a natively unstructured region of intersectin 1 proteins, lying between the first pair of SH3 domains, that binds to the clathrin adaptor AP2. This binding forms an intersectin-AP2 complex that functions as an important regulator of clathrin-mediated SV recycling in synapses.