SII-SWORD/CoKE huggingface dataset:
Pfam PF05080: Protein of unknown function (DUF681) (family)
This family contains several uncharacterised beak and feather disease virus proteins.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF24704: Family of unknown function (DUF7667) (family)
This entry represents a small family of uncharacterised bacterial proteins. Structure prediction shows these proteins are alpha helical with a long central alpha helix packed against two shorter N and C-terminal helices. Structure prediction suggests these proteins may form homodimers.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF22485: Domain of unknown function (DUF6987) (domain)
This alpha helical domain is usually found at the C-terminus of proteins containing repeats of [pfam:PF12396].
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF11793: FANCL C-terminal domain (domain)
This domain is found at the C-terminus of the Fancl protein in humans which is the E3 ubiquitin ligase subunit of the FA complex (Fanconi anaemia) that mediates monoubiquitination of FANCD2. This entry represents the RING domain which recruits the UBE2T ubiquitin conjugating E2 enzyme as other RING E3s.
Pfam PF09870: Uncharacterized protein conserved in archaea (DUF2097) (family)
This domain, found in various hypothetical prokaryotic proteins, has no known function.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF11834: KHA, dimerisation domain of potassium ion channel (family)
KHA is the tetramerisation domain of eukaryotic voltage-dependent potassium ion-channel proteins.  In plants the domain lies at the C-terminus whereas in many chordates it lies at the N-terminus.
Pfam PF21528: Coiled-coil and C2 domain-containing protein 1, DM14 domain (coiled_coil)
This entry includes coiled-coil and C2 domain-containing protein 1A/B (CC2D1A/B, also known as Freud-1/2). CC2D1A is involved in many pathways, including nuclear factor kappaB, PDK1/Akt, cAMP/PKA, Notch and bone morphogenetic protein. It is a calcium-regulated repressor of serotonine receptor 5-HT1A and dopamine-D2 receptor expression. CC2D1B binds to the 5-HT1A DRE and represses the human 5-HT1A receptor gene to regulate its expression in non-serotonergic cells and neurons. CC2D1A and CC2D1B have also been shown to interact with the CHMP4 family of proteins, the major subunit of the ESCRT-III complex. They may regulate degradation and signaling of EGFR and TLR4. CC2D1A and CC2D1B share conserved domains, including several DM14 domains that are specific to this protein family, a C-terminal helix-loop-helix domain, and a C2 domain. The CC2D1A C2 domain is thought to be calcium insensitive and it lacks several acidic residues that mediate calcium binding of the PKC C2 domain. The CC2D1B C2 domain appears to be essential for its DNA binding and repressor function; it may mediate protein-protein interactions. Mutations in the CC2D1A gene has been linked to nonsyndromic mental retardation. This entry represents the helical DM14 domain, unique to this family of proteins which is present four times. The function is not known but they seem to be important for NF-kB activation.
Pfam PF20354: Family of unknown function (DUF6649) (family)
This family of proteins is functionally uncharacterised. This family of proteins is found in eukaryotes. Proteins in this family are typically between 197 and 268 amino acids in length.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF15486: Domain of unknown function (DUF4644) (family)
This family of proteins is found in eukaryotes. Proteins in this family are typically between 143 and 191 amino acids in length.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF06130: Phosphate propanoyltransferase (family)
This family includes phosphotransacylases (PTACs) in particular PduL which is a specialised phosphotransacylase that plays a key role in the 1,2-propanediol utilisation (Pdu) pathway in certain  bacteria. Unlike the more common phosphotransacetylase (Pta),  PduL specifically catalyses the reversible conversion of  propionyl-CoA to propionyl phosphate. It is structurally  distinct from Pta, representing a unique family of  phosphotransacylases with a different protein fold and catalytic  mechanism. PduL is often associated with bacterial  microcompartments (BMCs), protein-based organelles that  encapsulate specific metabolic processes.
Pfam PF24888: Domain of unknown function (DUF7741) (domain)
This is a presumed domain found in a group of uncharacterised sequences from worms. This domain may consist of eight beta-strands.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF23564: Follistatin-related protein 1, EF-hand domain pair (domain)
This is the EF-hand domain pair found in human Follistatin -like protein 1 (FSTL1), a secreted glycoprotein involved in angiogenesis, regulation of the immune response, cell proliferation and differentiation. EF-hands tend to occur in pairs or higher copy numbers.
Pfam PF01553: Acyltransferase (family)
This family contains acyltransferases involved in phospholipid biosynthesis and other proteins of unknown function.  This family also includes tafazzin [swissprot:Q16635], the Barth syndrome gene.
Wikipedia: This family contains acyltransferases involved in phospholipid biosynthesis and proteins of unknown function. This family also includes tafazzin, the Barth syndrome gene.
Pfam PF12279: Protein of unknown function (DUF3619) (family)
This protein is found in bacteria. Proteins in this family are about 140 amino acids in length. This protein has two conserved sequence motifs: AAR and DDLP.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF05191: Adenylate kinase, active site lid (domain)
Comparisons of adenylate kinases have revealed  a particular divergence in the active site lid. In some organisms, particularly the Gram-positive bacteria, residues in the lid domain have been mutated to cysteines and these cysteine residues are responsible for the binding of a zinc ion. The bound zinc ion in the lid domain, is clearly  structurally homologous to Zinc-finger domains. However, it is unclear whether the adenylate kinase lid is a novel zinc-finger DNA/RNA binding domain, or that the lid bound zinc serves a purely structural function.
Wikipedia: Adenylate kinase is a phosphotransferase enzyme that catalyzes the interconversion of the various adenosine phosphates. By constantly monitoring phosphate nucleotide levels inside the cell, ADK plays an important role in cellular energy homeostasis.
Pfam PF00746: LPXTG cell wall anchor motif (conserved_site)
Surface proteins from Gram-positive cocci are covalently linked to the bacterial cell wall by sortase, a membrane-anchored transpeptidase that cleaves proteins between the threonine and the glycine of a conserved LPxTG motif, with the formation of a thioester between the conserved cysteine of sortase and the threonine carboxyl group. The newly liberated C terminus of the threonine is transferred via an amide bond exchange to the amino group of the pentaglycine wall crossbridge, thereby tethering the C terminus end of the surface protein to the bacterial peptidoglycan .

Surface proteins from Gram-positive cocci contain an N-terminal signal peptide and a C-terminal sorting signal. The 35-residue sorting signal is composed of a conserved LPxTG motif, a hydrophobic domain, and a tail of positively charged residues.

In the case of immunoglobulin A1 proteases, the typical Gram-positive cell wall anchor motif LPxTG is located in their N-terminal regions, in contrast with other known streptococcal and staphylococcal proteins .

This entry represents a domain covering the LPxTG motif, the hydrophobic stretch and the positively charged region.
Wikipedia: M protein is a virulence factor that can be produced by certain species of Streptococcus.
Pfam PF19479: Family of unknown function (DUF6015) (family)
This family of proteins is functionally uncharacterised. This family of proteins is found in archaea. Proteins in this family are typically between 119 and 142 amino acids in length.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF16757: Alpha-L-fucosidase C-terminal domain (domain)
The C-terminal domain of PDB:1hl8 is constructed of eight anti-parallel-strands packed into two-sheets of five and three strands, respectively, forming a two-layer-sandwich containing a Greek key motif.
Pfam PF12512: Protein of unknown function (DUF3717) (family)
This family of proteins is found in bacteria. Proteins in this family are typically between 75 and 117 amino acids in length. There is a conserved AIN sequence motif. There are two completely conserved residues (L and Y) that may be functionally important.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF02698: DUF218 domain (domain)
This domain contains several highly conserved charged amino acids, suggesting this may be an enzymatic domain (Bateman A pers. obs). The entry includes SanA [swissprot:P33017] and Sfix ([swissprot:O33790]) from Salmonella typhimurium which are involved in Vancomycin resistance. These proteins may be involved in murein synthesis. This domain is found in Escherichia coli YdcF, which has been shown to bind S-adenosyl-L-methionine (AdoMet), but whose biochemical function has not been identified.
Pfam PF08720: Influenza C hemagglutinin stalk (domain)
This domain corresponds to the stalk segment of hemagglutinin in influenza C virus.  It forms a coiled coil structure.
Wikipedia: Influenza hemagglutinin (HA) or haemagglutinin[p] is a homotrimeric glycoprotein found on the surface of influenza viruses and is integral to its infectivity.
Pfam PF11359: Envelope glycoprotein UL132 (family)
Glycoprotein UL132 is a low-abundance structural component of Human cytomegalovirus (HCMV) which is important for viral replication. It is essential for the formation of the viral assembly compartment (AC) which is critical for the efficient production of infectious particles.
Pfam PF23313: KIF14 four-helical bundle (domain)
This is a four helical bundle domain (4HB) found in Kinesin-like protein KIF14 a microtubule motor protein that binds to microtubules with high affinity through each tubulin heterodimer and has an ATPase activity. It plays a role in many processes like cell division, cytokinesis and also in cell proliferation and apoptosis.
Pfam PF21008: Allograft inflammatory factor 1 (domain)
AIF-1 is an actin-binding protein that enhances membrane ruffling and RAC activation. It contains two calcium binding EF hand motifs.
Pfam PF18736: HEPN pEK499 p136 (domain)
pEK499_p136-like HEPN.
Pfam PF17006: Domain of unknown function (DUF5087) (family)
This is a family of microsporidial sequences of unknown function.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF10525: Engrailed homeobox C-terminal signature domain (domain)
Engrailed homeobox proteins are characterised by the presence of a conserved region of some 20 amino-acid residues located at the C-terminal of the 'homeobox' domain. This domain of approximately 20 residues forms a kind of a signature pattern for this subfamily of proteins.
Wikipedia: In molecular biology, the engrailed homeobox proteins are a family of homeobox proteins which are characterised by the presence of a region of some 20 amino-acid residues located at the C-terminal of the 'homeobox' domain. This region forms a signature pattern for this subfamily of proteins.
Pfam PF11637: UvsW.1 domain (domain)
This domain represents the UvsW.1 domain that is typically encoded by the gene adjacent to that of phage UvsW-like SF2 helicases. UvsW.1 features a trihelical bundle fold that is related to other nucleic acid binding domains such as the HRDC domain of the RecQ helicases.
Pfam PF13672: Protein phosphatase 2C (family)
Protein phosphatase 2C is a Mn++ or Mg++ dependent protein serine/threonine phosphatase.
Pfam PF02425: Paralytic/GBP/PSP peptide (family)
This family includes insect peptides that are short (23 amino acids) and contain 1 disulphide bridge.  The family includes growth-blocking peptide (GBP) of Pseudaletia separata and the paralytic peptides from Manduca sexta, Heliothis virescens, and Spodoptera exigua as well as plasmatocyte-spreading peptide (PSP1). These peptides function to halt metamorphosis from larvae to pupae.
Wikipedia: Paralytic peptides are a family of short insect peptides that halt metamorphosis of insects from larvae to pupae. These peptides contain one disulphide bridge. The family includes growth-blocking peptide (GBP) of Mythimna separata and the paralytic peptides from Manduca sexta, Heliothis virescens, and Spodoptera exigua as well as plasmatocyte-spreading peptide (PSP1).
Pfam PF16840: Actin-like protein 7A N-terminus (domain)
The N-terminus of actin-like protein 7A is required for interaction with testin (TES).
Pfam PF21845: Domain of unknown function (DUF6904) (domain)
This entry represents an uncharacterised family of bacterial proteins. Members of the family are about 250 residues in length.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF09126: Restriction endonuclease NaeI (domain)
Members of this family adopt a secondary structure consisting of nine alpha-helices, six 3-10 helices and 13 beta-strands. They bind two GCC-CGG recognition sequences to cleave DNA into blunt-ended products.
Pfam PF19948: Family of unknown function (DUF6410) (family)
This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0001062) is described by MIBiG as an example of the following biosynthetic class, polyketide, in particular the  TLN-05220 biosynthetic gene cluster from Micromonospora echinospora subsp. challisensis.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF08665: PglZ domain (domain)
This family is a member of the Alkaline phosphatase clan.
Pfam PF10834: Protein of unknown function (DUF2560) (family)
This family of proteins has no known function.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF18786: Importin 13 repeat (repeat)
Importin 13 serves as receptor for nuclear localization signals (NLS) in cargo substrates. It mediates docking of the importin/substrate complex to the nuclear pore complex (NPC). It contains several repeats structurally similar to the HEAT repeat. This Pfam entry represents a single repeat unit.
Pfam PF16319: Surface glycan binding protein BT4661-like (family)
This protein family, mainly found in Bacteroides, includes the putative surface glycan binding protein (SGBP) BT4661 from Bacteroides thetaiotaomicron ([swissprot:Q89YS0]). BT4661 appears to play a role in the bacterial degrading apparatus of the host glycosaminoglycans heparin (Hep) and heparan sulfate (HS). It shows six discrete domains that adopt an Ig-like fold arranged in an extended, curved conformation.
Pfam PF03190: Protein of unknown function, DUF255 (family)
This entry represents the TRX domain found in highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length. This domain contains a redox active CXXC motif. The human/rat protein, called Spermatogenesis-associated protein 20 (SSP411), is specifically expressed in the testis in an age-dependent manner. The SSP411 mRNA is increased during spermiogenesis and is localized in round and elongated spermatids, suggesting a function in fertility regulation .
Pfam PF24850: Bacillithiol biosynthesis BshC, C-terminal coiled-coil domain (domain)
This entry represents the C-terminal coiled-coil domain of the bacillithiol biosynthesis protein BshC from Bacillus subtilis, which has been described as a cysteine-adding enzyme. This domain, found associated with [pfam:PF10079], shows a four-helix bundle and is responsible for the dimerisation of the protein.
Pfam PF21294: Polysaccharide lyase 14 (family)
This protein family includes Alginate lyase from the mollusc Aplysia kurodai (AkAly30) and similar proteins from prokaryotes, eukaryotes and some viral species. AkAly30 degrades alginate by cleaving the glycosidic bond through a beta-elimination reaction. This enzyme adopts a beta-jelly roll fold comprising two antiparallel beta- sheets. Some beta strands of the first sheet twist to form an electropositive-rich cavity where the substrates are believed to be located.
Pfam PF11444: Protein of unknown function (DUF2895) (family)
This is a bacterial family of uncharacterised proteins.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF24471: DEAH11-like, KH-domain (domain)
This presumed KH domain is found in ATP-dependent RNA helicase DEAH11 from Arabidopsis thaliana and similar sequences from plants and animals. Its specific function is unknown.
Pfam PF05522: Metallothionein (family)
This family consists of metallothioneins from several worm and sea urchin species. Metallothioneins are low molecular weight, cysteine rich proteins known to be involved in heavy metal detoxification and homeostasis.
Wikipedia: Metallothionein (MT) is a family of cysteine-rich, low molecular weight proteins. They are localized to the membrane of the Golgi apparatus. MTs have the capacity to bind both physiological and xenobiotic heavy metals through the thiol group of its cysteine residues, which represent nearly 30% of its constituent amino acid residues.
Pfam PF10975: Protein of unknown function (DUF2802) (family)
This bacterial family of proteins has no known function.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF11092: Neuronal protein 3.1 (p311) (family)
P311 has several PEST-like motifs and is found in neuron and muscle cells. P311 could have some function in myo-fibroblast transformation and prevention of fibrosis. It has also been identified as a potential regulator of alveolar generation.