SII-SWORD/CoKE huggingface dataset:
Pfam PF20177: Domain of unknown function (DUF6542) (domain)
This entry represents an integral membrane domain composed of four predicted transmembrane helices. The function of this region is unknown.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF05223: NTF2-like N-terminal transpeptidase domain (domain)
The structure of this domain from MecA is known [swissprot:Q53707] and is found to be similar to that found in NTF2 [pfam:PF02136]. This domain seems unlikely to have an enzymatic function, and its role remains unknown.
Pfam PF02820: mbt repeat (domain)
The function of this repeat is unknown, but is found in a number of nuclear proteins such as drosophila sex comb on midleg protein [swissprot:Q9VHA0]. The repeat is found in up to four copies as in [swissprot:Q9UHJ3]. The repeat contains a completely conserved glutamate at its amino terminus that may be important for function.
Pfam PF11337: Protein of unknown function (DUF3139) (family)
This family of proteins with unknown function appears to be restricted to Firmicutes.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF06223: Minor tail protein T (family)
Minor tail protein T is located at the distal end and is involved in the assembly of the initiator complex for tail polymerisation.  According to AlphaFold models this protein forms a confident homo-hexameric complex.
Pfam PF01966: HD domain (family)
HD domains are metal dependent phosphohydrolases.
Wikipedia: In molecular biology, the HD domain is a conserved protein domain, named after the conserved histidine (H) and/or aspartate (D) amino acid residues. It is found in a superfamily of enzymes with a predicted or known phosphohydrolase activity. These enzymes appear to be involved in nucleic acid metabolism, signal transduction and possibly other functions in bacteria, archaea and eukaryotes. The fact that all the highly conserved residues in the HD superfamily are histidines or aspartates suggests that coordination of divalent cations is essential for the activity of these proteins.
Pfam PF11715: Nucleoporin Nup120/160, beta-propeller domain (repeat)
Nup120 is conserved from fungi to plants to humans, is homologous to Nup160 of vertebrates. The nuclear core complex, or NPC, mediates macromolecular transport across the nuclear envelope. Deletion of the NUP120 gene causes clustering of NPCs at one side of the nuclear envelope, moderate nucleolar fragmentation and slower cell growth. Nup120 is one of the proteins involved in creating the nucleoporin basket together with Nup98 and Nup153, which plays a role in mRNA export. This entry represents the beta-propeller domain for Nup120 and Nup160.
Pfam PF00895: ATP synthase protein 8 (family)
Transmembrane ATPases are membrane-bound enzyme complexes/ion transporters that use ATP hydrolysis to drive the transport of protons across a membrane. Some transmembrane ATPases also work in reverse, harnessing the energy from a proton gradient, using the flux of ions across the membrane via the ATPase proton channel to drive the synthesis of ATP.
F-ATPases (also known as ATP synthases, F1F0-ATPase, or H(+)-transporting two-sector ATPase) (7.1.2.2) are composed of two linked complexes: the F1 ATPase complex is the catalytic core and is composed of 5 subunits (alpha, beta, gamma, delta, epsilon), while the F0 ATPase complex is the membrane-embedded proton channel that is composed of at least 3 subunits (A-C), with additional subunits in mitochondria. Both the F1 and F0 complexes are rotary motors that are coupled back-to-back. In the F1 complex, the central gamma subunit forms the rotor inside the cylinder made of the Î±(3)Î²(3) subunits, while in the F0 complex, the ring-shaped C subunits forms the rotor. The two rotors rotate in opposite directions, but the F0 rotor is usually stronger, using the force from the proton gradient to push the F1 rotor in reverse in order to drive ATP synthesis . These ATPases can also work in reverse in bacteria, hydrolysing ATP to create a proton gradient.
This entry represents subunit 8 found in the F0 complex of mitochondrial F-ATPases from Metazoa. This subunit appears to be an integral component of the stator stalk in yeast mitochondrial F-ATPases . The stator stalk is anchored in the membrane, and acts to prevent futile rotation of the ATPase subunits relative to the rotor during coupled ATP synthesis/hydrolysis. This subunit may have an analogous function in Metazoa. Subunit 8 differs in sequence between Metazoa, plants (IPR003319) and fungi (IPR009230).
Wikipedia: MT-ATP8 is a mitochondrial gene with the full name 'mitochondrially encoded ATP synthase membrane subunit 8' that encodes a subunit of mitochondrial ATP synthase, ATP synthase Fo subunit 8. This subunit belongs to the Fo complex of the large, transmembrane F-type ATP synthase. This enzyme, which is also known as complex V, is responsible for the final step of oxidative phosphorylation in the electron transport chain. Specifically, one segment of ATP synthase allows positively charged ions, called protons, to flow across a specialized membrane inside mitochondria. Another segment of the enzyme uses the energy created by this proton flow to convert a molecule called adenosine diphosphate (ADP) to ATP. Subunit 8 differs in sequence between Metazoa, plants and Fungi.
Pfam PF18727: Alstrom syndrome repeat (repeat)
This entry contains a single repeat unit of approximately 47 AA. It is found in Alstrom syndrome protein 1 (ALMS1) and homologs.
Pfam PF17213: Hydin Adenylate kinase-like domain (domain)
This domain found in the Hydin protein is homologous to adenylate kinases.
Pfam PF04809: HupH hydrogenase expression protein, C-terminal conserved region (family)
This family represents a C-terminal conserved region found in these bacterial proteins necessary for hydrogenase synthesis. Their precise function is unknown.
Pfam PF06334: Orthopoxvirus A47 protein (family)
This family consists of several Orthopoxvirus A47 proteins. The function of this family is unknown.
Pfam PF04272: Phospholamban (domain)
The regulation of calcium levels across the membrane of the sarcoplasmic reticulum involves the interplay of many membrane proteins. Phospholamban is a 52 residue integral membrane protein that is involved in reversibly inhibiting the Ca(2+) pump and regulating the flow of Ca ions across the sarcoplasmic reticulum membrane during muscle contraction and relaxation. Phospholamban is thought to form a pentamer in the membrane.
Wikipedia: Phospholamban, also known as PLN or PLB, is a micropeptide protein that in humans is encoded by the PLN gene. Phospholamban is a 52-amino acid integral membrane protein that regulates the calcium (Ca2+) pump in cardiac muscle cells.
Pfam PF10482: Tumour-suppressor protein CtIP N-terminal domain (coiled_coil)
CtIP is predominantly a nuclear protein that complexes with both BRCA1 and the BRCA1-associated RING domain protein (BARD1). At the protein level, CtIP expression varies with cell cycle progression in a pattern identical to that of BRCA1. Thus, the steady-state levels of CtIP polypeptides, which remain low in resting cells and G1 cycling cells, increase dramatically as Dividing cells traverse the G1/S boundary. CtIP can potentially modulate the functions ascribed to BRCA1 in transcriptional regulation, DNA repair, and/or cell cycle checkpoint control. This N-terminal domain carries a coiled-coil region and is essential for homodimerisation of the protein. The C-terminal domain is family [pfam:PF08573].
Pfam PF19515: Domain of unknown function (DUF6048) (domain)
This entry represents a family of uncharacterised membrane spanning beta barrel proteins. This family of proteins is primarily found in Bacteroidetes bacteria. Proteins in this family are typically between 228 and 255 amino acids in length.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF20916: Cellulose Synthase Subunit B, alpha-beta domain (domain)
This domain is found in Cellulose Synthase Subunit B (BscB) from Cereibacter sphaeroides and similar sequences predominantly found in bacteria. BscB, involved in bacterial cellulose biosynthesis, is organized into two periplasmic carbohydrate binding domains (CBD-1/2, [pfam:PF03170]) and two alpha/beta-domains with similarity with a flavodoxin-fold (FD1 and FD2). This entry represents FD2.
Pfam PF00791: ZU5 domain (family)
Domain present in ZO-1 and Unc5-like netrin receptors Domain of unknown function.
Pfam PF24589: Domain of unknown function (DUF7614) (domain)
This domain is found in uncharacterised proteins mainly from fungi. It is predicted to fold into a beta-barrel with a PH-like topology.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF12618: PHD finger protein 20, AT-hook (domain)
PHD finger protein 20 (PHF20) is a Methyllysine-binding protein, component of the MOF histone acetyltransferase protein complex. It consists of tandem Tudor domains at the N-terminal, an AT hook, a C2H2-type zinc finger, and a plant homeodomain (PHD) finger. This entry represents the AT-hook domain, a putative DNA-binding domain.
Pfam PF07763: FEZ-like protein (family)
This is a family of eukaryotic proteins thought to be involved in axonal outgrowth and fasciculation. The N-terminal regions of these sequences are less conserved than the C-terminal regions, and are highly acidic.  The C. elegans homolog, UNC-76 ([swissprot:Q7JNU9]), may play structural and signalling roles in the control of axonal extension and adhesion (particularly in the presence of adjacent neuronal cells) and these roles have also been postulated for other FEZ family proteins. Certain homologs have been definitively found to interact with the N-terminal variable region (V1) of PKC-zeta, and this interaction causes cytoplasmic translocation of the FEZ family protein in mammalian neuronal cells. The C-terminal region probably participates in the association with the regulatory domain of PKC-zeta. The members of this family are predicted to form coiled-coil structures, which may interact with members of the RhoA family of signalling proteins, but are not thought to contain other characteristic protein motifs. Certain members of this family are expressed almost exclusively in the brain, whereas others (such as FEZ2, [swissprot:Q76LN0]) are expressed in other tissues, and are thought to perform similar but unknown functions in these tissues.
Wikipedia: In molecular biology, the FEZ-like protein family is a family of eukaryotic proteins thought to be involved in axonal outgrowth and fasciculation. The N-terminal regions of these sequences are less conserved than the C-terminal regions, and are highly acidic. The Caenorhabditis elegans homologue, UNC-76, may play structural and signalling roles in the control of axonal extension and adhesion and these roles have also been postulated for other FEZ family proteins. Certain homologues have been definitively found to interact with the N-terminal variable region (V1) of PKC-zeta, and this interaction causes cytoplasmic translocation of the FEZ family protein in mammalian neuronal cells. The C-terminal region probably participates in the association with the regulatory domain of PKC-zeta. The members of this family are predicted to form coiled-coil structures which may interact with members of the RhoA family of signalling proteins, but are not thought to contain other characteristic protein motifs. Certain members of this family are expressed almost exclusively in the brain, whereas others are expressed in other tissues, and are thought to perform similar but unknown functions in these tissues.
Pfam PF21344: Alpha-aminoadipate carrier protein LysW-like, globular domain (domain)
This domain is found in a group of prokaryotic proteins, including Alpha-aminoadipate carrier protein LysW from Thermus thermophilus. LysW is an amino group-carrier protein that plays an important role in lysine biosynthesis. This globular domain is composed of five beta-strands and adopts a similar structure to members of the zinc ribbon superfamily. It is responsible for the binding of a zinc atom.
Pfam PF13926: Domain of unknown function (DUF4211) (family)
This presumed domain is functionally uncharacterised.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF05730: CFEM domain (domain)
This fungal specific cysteine rich domain is found in some proteins with proposed roles in fungal pathogenesis. The structure of  the CFEM domain containing protein 'Surface antigen protein 2' from  Candida albicans ([swissprot:Q5A0X8]) has been solved.
Pfam PF24206: Family of unknown function (DUF7429) (family)
This entry represents a family of small uncharacterised proteins found in mycobacterial phage.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF24620: Domain of unknown function (DUF7625) (domain)
This domain is found in uncharacterised proteins mainly from plants. This domain is predicted to fold into a globular structure with a winged helix HTH topology.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF02433: Cytochrome C oxidase, mono-heme subunit/FixO (family)
The bacterial oxidase complex, fixNOPQ or cytochrome cbb3, is thought to be required for respiration in endosymbiosis. FixO is a membrane bound mono-heme constituent of the fixNOPQ complex.
Pfam PF05936: Bacterial Type VI secretion, VC_A0110, EvfL, ImpJ, VasE (family)
T6SS_VasE is a family of of bacterial proteins that are essential for the type VI pathogenic secretion system, although the exact function of this particular component of the system is still not known.
Pfam PF07631: Protein of unknown function (DUF1592) (family)
A region of similarity shared by several Rhodopirellula baltica cytochrome-like proteins that are predicted to be secreted. These proteins also match [pfam:PF07627], [pfam:PF07626], and [pfam:PF07624].
Pfam PF17361: Family of unknown function (DUF5387) (family)
This is a family of unknown function found in Strongyloides.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF17101: Stealth protein CR1, conserved region 1 (family)
Stealth_C1 is the first of several highly conserved regions on stealth proteins in metazoa and bacteria. There are up to four CR regions on all member proteins.  CR1 carries a well-conserved IDVVYT sequence-motif. The domain is found in tandem with CR2, CR3 and CR4 on both potential metazoan hosts and pathogenic eubacterial species that are capsular polysaccharide phosphotransferases.  The CR domains appear on eukaryotic proteins such as GNPTAB, N-acetylglucosamine-1-phosphotransferase subunits alpha/beta. Horizontal gene-transfer seems to have occurred between host and bacteria of these sequence-regions in order for the bacteria to evade detection by the host innate immune system.
Pfam PF09783: Vacuolar import and degradation protein (family)
Members of this family are involved in the negative regulation of gluconeogenesis. They are required for both proteosome-dependent and vacuolar catabolite degradation of fructose-1,6-bisphosphatase (FBPase), where they probably regulate FBPase targeting from the FBPase-containing vesicles to the vacuole.
Pfam PF15902: Sortilin, neurotensin receptor 3, (repeat)
Sortilin, also known in mammals as neurotensin receptor-3, is the archetypical member of a Vps10-domain (Vps10-D) that binds neurotrophic factors and neuropeptides. This domain constitutes the entire luminal part of Sortilin and is activated in the trans-Golgi network by enzymatic propeptide cleavage. The structure of the domain has been determined as a ten-bladed propeller, with up to 9 BNR or beta-hairpin turns in it. The mature receptor binds various ligands, including its own propeptide (Sort-pro), neurotensin, the pro-forms of nerve growth factor-beta (NGF)6 and brain-derived neurotrophic factor (BDNF)7, lipoprotein lipase (LpL), apo lipoprotein AV14 and the receptor-associated protein (RAP)1.
Pfam PF21067: Rotavirus non-structural protein 35, N-terminal (domain)
Rotavirus non-structural protein 35 (NS35, also known as NSP2) is a basic protein which possesses RNA-binding, and helix-destabilising activities in addition to nucleoside and 5' RNA triphosphatase (NTPase/RTPase) and nucleoside-diphosphate (NDP) kinase-like  activities. NS35 forms a functional octamer which is essential for genome replication and formation of viroplasms. This is the N-terminal domain, which contains basic residues, that in addition to the basic residues in the C-terminal helix, are important for sequence-independent RNA binding of NS35. This domain also has conserved cysteine residues which form disulfide that might be relevant for NS35 activity.
Wikipedia: NSP2 (NS35), is one of five to six nonstructural proteins expressed by rotaviruses. The octameric NSP2 performs several key functions in the assembly of rotavirus particles. This nonstructural RNA-binding protein accumulates in cytoplasmic inclusions (viroplasms) and is required for genome replication. NSP2 is closely associated in vivo with the viral replicase. The non-structural protein NSP5 plays a role in the structure of viroplasms mediated by its interaction with NSP2.
Pfam PF23785: Protein of unknown function (DUF7171) (family)
This entry represents a domain of unknown function found in bacterial and phage proteins, particularly in Gordonia phages. The domain is approximately 140 amino acids in length. It contains regions of disorder at the N- and C-termini.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF01228: Glycine radical (domain)
Glycyl radical enzymes are involved in a great variety of functions, including nucleotide, pyruvate and toluene metabolism . A glycyl radical is formed by the removal of a hydrogen from a glycine and the resulting radical is located on the protein main chain.

Escherichia coli formate C-acetyltransferase (2.3.1.54) is a key enzyme of anaerobic glucose metabolism; it converts pyruvate and CoA into acetyl-CoA and pyruvate. It is posttranslationally interconverted, under anaerobic conditions, from an inactive to an active form that carries a stable radical localised to a specific glycine at the C terminus . Such a glycine radical is also present in E. coli (gene nrdD)  and Bacteriophage T4 (gene nrdD or sunY) anaerobic ribonucleoside-triphosphate reductases (1.17.4.2). In these enzymes the glycyl radical is located at the C-terminal part of the enzyme . An autonomous glycyl radical cofactor also exists in Escherichia coli and bacteriophage T4 (gene grcA) .

This entry represents a domain covering the conserved region around the glycine radical.
Pfam PF18155: pPIWI RE three-gene island domain Z (domain)
Poorly-understood domain observed N-terminal to DinG-type helicase, which is part of a conserved three-gene island also containing a REase domain and the pPIWI_RE module. This three gene island is predicted to form a conflict system which targets R-loop formation of invasive plasmids during plasmid replication.
Pfam PF13997: YqjK-like protein (family)
The YqjK-like protein family includes the E. coli YqjK protein [swissprot:Q47710] which is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 100 amino acids in length. There is a single completely conserved residue R that may be functionally important.
Pfam PF06356: Protein of unknown function (DUF1064) (family)
This family consists of several phage and bacterial proteins of unknown function. Computational analysis involving sequence, predicted structure and genomic context suggests that these proteins may be endonucleases which function in phage genome segregation, or the repair of double-stranded breaks introduced during either this process or DNA replication.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.