SII-SWORD/CoKE huggingface dataset:
Pfam PF19240: Family of unknown function (DUF5890) (family)
This is a family of uncharacterised proteins found in viruses, which presumably contain a Host Targeting (HT) motif. This motif is involved in targeting host proteins as part of the infection process in several organisms.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF07746: Aromatic-ring-opening dioxygenase LigAB, LigA subunit (family)
This is a family of aromatic ring opening dioxygenases which catalyse the ring-opening reaction of protocatechuate and related compounds.
Pfam PF07593: ASPIC and UnbV (family)
This conserved sequence is found associated with [pfam:PF00515] in several paralogous proteins in Rhodopirellula baltica.  It is also found associated with [pfam:PF01839] in several eukaryotic integrin-like proteins (e.g. human ASPIC [swissprot:Q9NQ78]) and in several other bacterial proteins (e.g. [swissprot:Q84HN1]).
Pfam PF05755: Rubber elongation factor protein (REF) (family)
This family consists of the highly related rubber elongation factor (REF), small rubber particle protein (SRPP) and stress-related protein (SRP) sequences. REF and SRPP are released from the rubber particle membrane into the cytosol during osmotic lysis of the sedimentable organelles (lutoids). The exact function of this family is unknown.
Pfam PF10074: T6SS, Transcription factor, DNA binding domain (domain)
This domain is found in a group of proteins from proteobacteria, including the hexameric transcription factor from Yersinia pseudotuberculosis RovC, which is essential for the activation of one of the Type VI secretion systems of this organism (T6SS4). This domain folds into a distinct variant of the helix-turn-helix domain that shows an 'extended-turn' motif. It is responsible for DNA binding, participating in transcriptional activation and antiactivation to initiate or inhibit horizontal gene transfer.
Pfam PF21997: Family of unknown function (DUF6928) (family)
This is a family of uncharacterised bacterial proteins. They are predicted to adopt alpha/beta structure with a central nine-stranded antiparallel beta-sheet with helices packed on both sides. The predicted structure has some partial structural similarity to bacterial S-adenosylmethionine decarboxylases.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF06871: TraH_2 (domain)
This family consists of several TraH proteins which seem to be specific to Agrobacterium and Rhizobium species. This protein is thought to be involved in conjugal transfer but its function is unknown. This family does not appear to be related to [pfam:PF06122].
Pfam PF08935: Viral protein VP4 subunit (domain)
This domain is predominantly found in viral proteins from the family Picornaviridae. It is VP4 of the viral polyprotein which, in poliovirus, is part of the capsid that consists of 60 copies each of four proteins VP1, VP2, VP3, and VP4 arranged on an icosahedral lattice. VP4 is on the inside and differs from the others in being small, myristoylated and having an extended structure. Productive infection involves the externalisation of the VP4, which is cleaved from the rest, along with the N-terminus of VP1. There thus seem to be three stages of the virus, ie a multi-step process for cell entry involving RNA translocation through a membrane channel formed by the externalised N termini of VP1.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF24129: Family of unknown function (DUF7396) (family)
This entry represents an uncharacterized protein found in several bacteriophages that infect bacteria such as Escherichia coli, Enterobacter, Klebsiella and Shigella. The protein is short, around 44-51 amino acids in length. It is predicted to contain a single transmembrane helix. The function of this protein is currently unknown.  One representative of this family is the [swissprot:P18922] protein from bacteriophage T4.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF23032: ELAPOR1-like, galactose-binding domain (domain)
This domain is found in Endosome/lysosome-associated apoptosis and autophagy regulator family member 2 from humans (ELAPOR1), which may protect cells from cell death by inducing cytosolic vacuolisation and up-regulating the autophagy pathway and may play a role in apoptosis and cell proliferation. It is predicted to form a beta sandwich with a jelly roll topology typical of a galactose binding domain (GBD).
Pfam PF24236: Telomere ends associated alpha-helical domain (domain)
This entry represents a small domain that is present four times in Telomere ends associated protein (Tea) from Drosophila and related fly sequences. Tea protects telomeres from fusion and it likely functions as a component of the MTV complex along with moi and ver. The complex binds single-stranded DNA in a sequence-independent manner and can protect it from DNA degradation. This domain may adopt an alpha-helical fold.
Pfam PF06501: Human herpesvirus U55 protein (family)
This family consists of several human herpesvirus U55 proteins. The function of this family is unknown.
Pfam PF23979: Domain of unknown function (DUF7304) (domain)
This entry describes a family of uncharacterized proteins, around 70 amino acids in length, found in mycobacteriophages. The family members share sequence similarity but their function is currently unknown.  The domain is found as a single copy in the phage proteins. The domain adopts a compact globular fold with a four stranded beta sheet followed by an alpha helix.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF05971: RNA methyltransferase (family)
This family includes ribosomal RNA large subunit methyltransferase F, and related proteins, including methyltransferase-like protein 16 (METTL16). METTL16 is a conserved RNA methyltransferase which interacts specifically with the MALAT1 triple helix. METTL16 shows nuclear localisation. Another functional study indicates that METTL16 regulates expression of human MAT2A, which encodes the SAM synthetase expressed in most cells. Furthermore, results indicate that METTL16 is the long-unknown methyltransferase for the U6 spliceosomal small nuclear RNA (snRNA) and it has evolved an additional function in vertebrates to control SAM homeostasis by post-transcriptionally regulating SAM synthetase gene expression.
Pfam PF02173: pKID domain (family)
CBP and P300 bind to the pKID (phosphorylated kinase-inducible-domain) domain of CREB.
Pfam PF13854: Kelch motif (repeat)
The kelch motif was initially discovered in Kelch ([swissprot:Q04652]). In this protein there are six copies of the motif.  It has been shown that [swissprot:Q04652] is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet.  Several of these sheets associate to form a beta propeller structure as found in [pfam:PF00064], [pfam:PF00400] and [pfam:PF00415].
Wikipedia: The Kelch motif is a region of protein sequence found widely in proteins from bacteria and eukaryotes. This sequence motif is composed of about 50 amino acid residues which form a structure of a four stranded beta-sheet "blade". This sequence motif is found in between five and eight tandem copies per protein which fold together to form a larger circular solenoid structure called a beta-propeller domain.
Pfam PF16416: ARM-like repeat domain, GUN4-N terminal (repeat)
GUN4_N is the ARM-repeat like N-terminal domain of GUN4 proteins. It contains five helices arranged in an alternating antiparallel pattern that resembles ARM or HEAT repeats, though the functional importance of this poorly conserved domain in Gun4 is not currently known.
Pfam PF02645: Uncharacterised protein, DegV family COG1307 (family)
The structure of this protein revealed a bound fatty-acid molecule in a pocket between the two protein domains. The structure indicates that this family has the molecular function of fatty-acid binding and may play a role in the cellular functions of fatty acid transport or metabolism.
Pfam PF00093: von Willebrand factor type C domain (domain)
The high cutoff was used to prevent overlap with [pfam:PF00094].
Wikipedia: Von Willebrand factor, type C is a protein domain is found in various blood plasma proteins: complement factors B, C2, CR3 and CR4; the integrins (I-domains); collagen types VI, VII, XII and XIV; and other extracellular proteins.
Pfam PF04966: Carbohydrate-selective porin, OprB family (family)
The carbohydrate-selective porin OprB family includes the Pseudomonas aeruginosa porin B, a substrate-selective channel for a variety of different sugars. This protein may facilitate diffusion of a variety of diverse compounds, but is probably restricted to carbohydrates, and does facilitate glucose fusion across the outer membrane.
Pfam PF13415: Galactose oxidase, central domain (repeat)
Wikipedia: The Kelch motif is a region of protein sequence found widely in proteins from bacteria and eukaryotes. This sequence motif is composed of about 50 amino acid residues which form a structure of a four stranded beta-sheet "blade". This sequence motif is found in between five and eight tandem copies per protein which fold together to form a larger circular solenoid structure called a beta-propeller domain.
Pfam PF07344: Amastin surface glycoprotein (family)
This family contains the eukaryotic surface glycoprotein amastin (approximately 180 residues long).In Trypanosoma cruzi, amastin is particularly abundant during the amastigote stage.
Pfam PF24760: IF140 C-terminal TPR domain (repeat)
IFT140 is one of the core components (together with WDR19/IFT144 and IFT122) of the IFT-A complex which is required for retrograde ciliary transport and entry into cilia of G protein-coupled receptors (GPCRs), being involved in cilia function and/or assembly. IFT-A polymerises interacts with IFT-B, and uses an array of beta-propeller and TPR domains to create 'carriages' of the IFT train that engage TULP adaptor proteins. The beta-propeller domains of IFT140 contact the beta-propeller domains of IFT121 from the adjacent complex. This entry represents the TPR domain found at the C-terminal of IFT140.
Pfam PF16739: Caspase recruitment domain (domain)
In the probable ATP-dependent RNA helicase DDX58 this CARD domain is found near the N-terminus and interacts with the C-terminal domain.
Pfam PF00025: ADP-ribosylation factor family (domain)
Pfam combines a number of different Prosite families together
Wikipedia: ADP ribosylation factors (ARFs) are members of the ARF family of GTP-binding proteins of the Ras superfamily. ARF family proteins are ubiquitous in eukaryotic cells, and six highly conserved members of the family have been identified in mammalian cells. Although ARFs are soluble, they generally associate with membranes because of N-terminus myristoylation. They function as regulators of vesicular traffic and actin remodelling.
Pfam PF10675: Protein of unknown function (DUF2489) (domain)
This is a bacterial family of uncharacterised proteins.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF02824: TGS domain (domain)
The TGS domain is named after ThrRS, GTPase, and SpoT. Interestingly, TGS domain was detected also at the amino terminus of the uridine kinase from the spirochaete Treponema pallidum (but not any other organism, including the related spirochaete Borrelia burgdorferi). TGS is a small domain that consists of ~50 amino acid residues and is predicted to possess a predominantly  beta-sheet structure. There is no direct information on the functions of the TGS domain, but its presence in two types of regulatory proteins (the GTPases and guanosine polyphosphate phosphohydrolases/synthetases) suggests a ligand (most likely nucleotide)-binding, regulatory role.
Pfam PF05721: Phytanoyl-CoA dioxygenase (PhyH) (domain)
This family is made up of several eukaryotic phytanoyl-CoA dioxygenase (PhyH) proteins, ectoine hydroxylases and a number of bacterial deoxygenases. PhyH is a peroxisomal enzyme catalysing the first step of phytanic acid alpha-oxidation. PhyH deficiency causes Refsum's disease (RD) which is an inherited neurological syndrome biochemically characterised by the accumulation of phytanic acid in plasma and tissues.
Pfam PF24352: Family of unknown function (DUF7512) (family)
This entry represents a family of small uncharacterised proteins from Halobacteria. They are predicted to fold into a single alpha-helix and contain a highly conserved LYxGYG sequence motif.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF18469: Pleckstrin homology domain (domain)
This is a Pleckstrin Homology (PH) domain found on the N-terminal region of the histone chaperone Rtt106 in yeast. Rtt106 binds histone H3 acetylated at lysine 56 (H3K56ac) and facilitates nucleosome assembly during several molecular processes and this N-PH domain is shown to mediate histone binding.
Wikipedia: Pleckstrin homology domain or (PHIP) is a protein domain of approximately 120 amino acids that occurs in a wide range of proteins involved in intracellular signaling or as constituents of the cytoskeleton.
Pfam PF25075: Domain of unknown function (DUF7799) (repeat)
This entry represents a presumed domain found towards the N-terminal of a group of uncharacterised sequences from C. elegans and related proteins from nematodes. This domain may consist of spectrin repeats.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF13687: Domain of unknown function (DUF4153) (domain)
Members of this family are annotated as putative inner membrane proteins.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF10752: Protein of unknown function (DUF2533) (family)
This family of proteins with unknown function appears to be restricted to Bacillus spp.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF09809: Mitochondrial ribosomal protein L27 (family)
Members of this family of proteins are components of the mitochondrial ribosome large subunit. They are also involved in apoptosis and cell cycle regulation.
Pfam PF07389: Vaccinia B6 protein (family)
This family consists of several Orthopoxvirus specific proteins, which include Vaccinia virus, B6 protein, of around 170 residues in length. The function of this family is unknown.
Pfam PF09840: Uncharacterized protein conserved in archaea (DUF2067) (family)
This domain, found in various archaeal proteins, has no known function.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF21030: WD repeat-containing protein 93 (repeat)
This entry represents the beta-propeller of WD repeat-containing protein 93 (WDR93). Its function is unknown.
Pfam PF07377: Protein of unknown function (DUF1493) (domain)
This family consists of several bacterial proteins of around 115 residues in length. Members of this family seem to be found exclusively in Salmonella and Yersinia species and several have been described as being putative cytoplasmic proteins. The function of this family is unknown.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF21152: Glucosidase YgjK, N-terminal (domain)
This domain is found at the N-terminal end of Glucosidase YgjK from Escherichia coli and similar bacterial enzymes from the glycoside hydrolase family 63 (GH63) from bacteria, archaea, and eukaryotes. YgjK is organised into N- and A- domains and a linker between them. This entry includes the N-domain and the linker. The N-domain is composed of 18 antiparallel beta-strands divided into two beta- sheets and is classified as a super-beta-sandwich. The linker is composed of two helices and produces a significant curvature between the two domains.
Pfam PF23634: CERLI1-like PH domain (domain)
This entry represents a PH domain that is found in the Rhoptry Surface Protein CERLI1 family.  The Rhoptry Surface Protein CERLI1 family is essential for merozoite invasion of host cells, a critical step in the life cycle of the parasite Plasmodium falciparum. Members of the family control rhoptry secretion, which is pivotal for the successful invasion of host erythrocytes. The family proteins bind to specific lipids, including phosphatidic acid (PA) and phosphatidylinositol 4,5-bisphosphate (PIP2), suggesting a role in assembling the machinery that docks or primes the rhoptry to the parasite cell membrane prior to fusion with the host cell membrane. The cooperation between the C2 domain, which does not bind calcium, and the PH domain within these proteins is crucial for lipid binding and function.
Wikipedia: Pleckstrin homology domain or (PHIP) is a protein domain of approximately 120 amino acids that occurs in a wide range of proteins involved in intracellular signaling or as constituents of the cytoskeleton.
Pfam PF19933: Domain of unknown function (DUF6396) (domain)
This presumed domain of unknown function is found in uncharacterised proteins mainly from Proteobacteria, and is about 100 amino acids in length. It has the conserved sequences RxxRY and PLPPAxLPxWDG.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF23126: Domain of unknown function (DUF7048) (repeat)
This entry represents a domain found in uncharacterised proteins mainly from Trypanosoma sp. According to structural predictions, this domain is likely to adopt a beta-propeller fold.
Wikipedia: In structural biology, a beta-propeller (β-propeller) is a type of all-β protein architecture characterized by 4 to 8 highly symmetrical blade-shaped beta sheets arranged toroidally around a central axis. Together the beta-sheets form a funnel-like active site.
Pfam PF12684: PDDEXK-like domain of unknown function (DUF3799) (domain)
This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and viruses. Proteins in this family are typically between 265 and 420 amino acids in length. It appears that these proteins are distantly related to the PDDEXK superfamily and so these domains are likely to be nucleases. This family has a C-terminal cysteine cluster similar to that found in [pfam:PF01930].
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF10604: Polyketide cyclase / dehydrase and lipid transport (family)
This family contains polyketide cylcases/dehydrases which are enzymes involved in polyketide synthesis. It also includes other proteins of the START superfamily.
Pfam PF05423: Mycobacterium membrane protein (family)
This family contains several membrane proteins from Mycobacterium species.