SII-SWORD/CoKE huggingface dataset:
Pfam PF24216: Domain of unknown function (DUF7435) (domain)
This entry represents a family of uncharacterized proteins found in Mycobacterium phages. The family members are typically around 67 amino acids in length. Structure prediction suggests these proteins form a small compact domain composed of four beta strands followed by an Alpha helix. The domain possibly shows weak structural similarity to integrase arm-type binding domain.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF03158: Multigene family 530 protein (family)
Members of this family are multigene family 530 proteins from African swine fever viruses. These proteins may be involved in promoting survival of infected macrophages.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF13206: Trypanosomal VSG domain (domain)
This family represents the B-type variant surface glycoproteins from trypanosomal parasites. This family is related to [pfam:PF00913].
Pfam PF04420: CHD5-like protein (family)
Members of this family are probably coiled-coil proteins that are similar to the CHD5 (Congenital heart disease 5) protein. In Saccharomyces cerevisiae this protein localises to the ER and is thought to play a homeostatic role.
Pfam PF20204: Domain of unknown function (DUF6566) (domain)
This domain is found in functionally uncharacterised proteins from Burkholderiaceae. This domain is approximately 60 amino acids in length and it has a conserved tryptophan residue at the N-terminal, the conserved motifs PxW and AxRxxxE and an aspartate conserved residue at the C-terminal. Some members containing this domain are hypothetical transposases.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF05081: Autographa californica nuclear polyhedrosis virus (AcMNPV), P18 (family)
This family is represented by Autographa californica nuclear polyhedrosis virus (AcMNPV), P18; it is a family of uncharacterised viral proteins.
Pfam PF08917: Transforming growth factor beta receptor 2 ectodomain (domain)
The Transforming growth factor beta receptor 2 ectodomain is a compact fold consisting of nine beta-strands and a single helix stabilised by a network of six intra strand disulphide bonds. The folding topology includes a central five-stranded antiparallel beta-sheet, eight-residues long at its centre, covered by a second layer consisting of two segments of two-stranded antiparallel beta-sheets (beta1-beta4, beta3-beta9).
Wikipedia: Transforming growth factor, beta receptor II (70/80kDa) is a TGF beta receptor. TGFBR2 is its human gene.
Pfam PF09224: Domain of unknown function (DUF1961) (domain)
Members of this family are found in a set of hypothetical bacterial proteins. Their exact function has not, as yet, been determined.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF10296: Maintenance of mitochondrial morphology protein 1 (domain)
MMM1 is conserved from plants to humans. MMM1 is an integral ER protein. It is N-glycosylated, and forms a complex with Mdm10, Mdm12and Mdm34 to tether the mitochondria to the endoplasmic reticulum.
Pfam PF14840: Processivity clamp loader gamma complex DNA pol III C-term (family)
This domain lies at the C-terminus of the delta subunit of the DNA polymerase III clamp loader gamma complex. Within the complex the several C-terminal domains, of gamma, delta and delta' form a helical scaffold, on which the rest of he subunits are hung. The gamma complex, an AAA+ ATPase, is the bacterial homologue of the eukaryotic replication factor C that loads the sliding clamp (beta, homologous to PCNA) onto DNA.
Pfam PF19360: TadB/TadC N-terminal domain (domain)
This presumed domain is functionally uncharacterised but is found at the N-terminus of type II secretion protein TadB or TadC. This domain family is mainly found in alpha proteobacteria, and is approximately 140 amino acids in length. The family is found in association with [pfam:PF00482].
Pfam PF08432: AAA-ATPase Vps4-associated protein 1 (family)
Vps Four-Associated 1, Vfa1, in yeast, is an endosomal protein that interacts with the AAA-ATPase Vps4. It would seem to be involved in regulating the trafficking of other proteins to the endocytic vacuole.  There is a CCCH zinc finger at the N-terminus.
Pfam PF15837: Domain of unknown function (DUF4716) (family)
This domain family is found in eukaryotes, and is approximately 60 amino acids in length.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF05195: Aminopeptidase P, N-terminal domain (domain)
This domain is structurally very similar to the creatinase N-terminal domain ([pfam:PF01321]). However, little or no sequence similarity exists between the two families.
Pfam PF02939: UcrQ family (family)
The ubiquinol-cytochrome C reductase complex (cytochrome bc1 complex) is a respiratory multienzyme complex. This family represents the  9.5 kDa subunit of the complex.
Wikipedia: The coenzyme Q : cytochrome c – oxidoreductase, sometimes called the cytochrome bc1 complex, and at other times complex III, is the third complex in the electron transport chain, playing a critical role in biochemical generation of ATP. Complex III is a multisubunit transmembrane protein encoded by both the mitochondrial and the nuclear genomes. Complex III is present in the mitochondria of all animals and all aerobic eukaryotes and the inner membranes of most bacteria. Mutations in Complex III cause exercise intolerance as well as multisystem disorders. The bc1 complex contains 11 subunits, 3 respiratory subunits, 2 core proteins and 6 low-molecular weight proteins.
Pfam PF24205: T4-like virus antiholin family (family)
Antiholins (also known as RI) are bacteriophage proteins that inhibit lysis of host cells by interacting and inhibiting holin, the protein that forms micropores in the host bacterial cell membrane. Antiholin prevents holin forming homo-oligomers. Antiholin has an N-terminal signal anchor release (SAR) domain which not only directs itself to the periplasm, but also targets itself for degradation by the host serine peptidase DegP. These proteins share a C-terminal three helical bundle domain. This may form a homodimer according to structure predictions.
Pfam PF23912: Domain of unknown function (DUF7254) (domain)
This entry represents a small family of uncharacterised phage proteins that adopt a compact domain composed of a four stranded beta sheet followed by two alpha helices packed on one side of the sheet.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF05366: Sarcolipin (family)
Sarcolipin is a 31 amino acid integral membrane  protein that regulates Ca-ATPase activity in skeletal  muscle.
Pfam PF14815: NUDIX domain (domain)
This entry represents the C-terminal domain of MutY. Its structure is similar to the NUDIX fold, which is an Î±/Î²/Î± sandwich .
Adenine DNA glycosylase (called MutY in bacteria and hMYH in humans) initiates repair of A-oxoG to C-G by removing the inappropriately paired adenine base from the DNA backbone. MutY belongs to a structural superfamily of proteins (the NUDIX hydrolase superfamily) that hydrolyse a wide range of organic pyrophosphates .
Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+ for their activity. They are also recognized by a highly conserved 23-residue nudix motif (GX5EX7REUXEEXGU, where U = I, L or V). However, DNA glycosylase does not seem to contain this signature motif. DNA glycosylase consists of 2 domains: the N-terminal domain contains the catalytic properties of the enzyme and the C-terminal domain affects substrate (oxoG) binding and enzymatic turnover. The C-terminal domain is highly similar to MutT, based on secondary structure and topology, despite low sequence identity. MutT sanitizes the nucleotide precursor pool by hydrolyzing oxo-dGTP to oxo-dGMO and inorganic pyrophosphate. The similarity strongly suggests that the two proteins share a common evolutionary origin .
Wikipedia: NUDIX hydrolases are a superfamily of hydrolytic enzymes capable of cleaving nucleoside diphosphates linked to x, hence their name. The reaction yields nucleoside monophosphate (NMP) plus X-P. Substrates hydrolysed by nudix enzymes comprise a wide range of organic pyrophosphates, including nucleoside di- and triphosphates, dinucleoside and diphosphoinositol polyphosphates, nucleotide sugars and RNA caps, with varying degrees of substrate specificity. Enzymes of the NUDIX superfamily are found in all types of organisms, including eukaryotes, bacteria and archaea.
Pfam PF15415: Fimbrillin-like (family)
This family of proteins is found in bacteria. Proteins in this family are typically between 348 and 360 amino acids in length. Analysis of structural comparisons shows this family to be part of the FimbA (CL0450) superfamily of adhesin components or fimbrillins.
Pfam PF15968: Membrane-anchored ion channel, Abi component (family)
RexB is a family of anti-lambda phage inner-membrane ion-channels with four transmembrane domains. On infection by phage, a phage protein-DNA complex is produced as a replication or recombination intermediate which activates RexA. RexA is an intracellular sensor that activates the membrane-anchored RexB. At least two RexA proteins are needed to activate one RexB protein. Activation opens the ion-channel leading to a drop in membrane potential, the outcome of which is the death of the host cell but also the cessation or abortion of the phage infection. RexA-RexB is one of the most well characterised bacterial abortive infection systems, or Abis.
Pfam PF04748: Divergent polysaccharide deacetylase (family)
This family is divergently related to [pfam:PF01522] (personal obs:Yeats C).
Pfam PF03041: lef-2 (family)
The lef-2 gene (for late expression factor 2) from baculovirus is required for expression of late genes. This gene has been shown to be specifically required for expression from the vp39 and polh promoters.  LEF-1 is a DNA primase and there is some evidence to suggest that LEF-2 may bind to both DNA and LEF-1.
Pfam PF11960: Domain of unknown function (DUF3474) (family)
This presumed domain is functionally uncharacterised. This domain is found in bacteria and eukaryotes. This domain is typically between 126 to 140 amino acids in length. This domain is found associated with [pfam:PF00487].
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF05088: Bacterial NAD-glutamate dehydrogenase, catalytic domain (domain)
This entry represents the catalytic domain of several proteins which are closely related to NAD-glutamate dehydrogenase found in Streptomyces clavuligerus. Glutamate dehydrogenases (GDHs) are a broadly distributed group of enzymes that catalyse the reversible oxidative deamination of glutamate to ketoglutarate and ammonia. The structure of GDH from Mycobacterium smegmatis revealed that it has long N- and C-terminal segments flanking the catalytic core which provide dimer-like interactions between pairs of monomers. The N-terminal segment is flexible and contains ACT-like and PAS-type domains that may play a role as metabolic sensors for allosteric regulation.
Pfam PF10963: Phage tail assembly chaperone (family)
This is a family of phage tail assembly chaperone proteins.
Pfam PF18358: Histone methyltransferase Tudor domain (domain)
This is a Tudor domain found in histone-lysine N-methyltransferase SETDB1 proteins ([ec:2.1.1.43]), also known as Eggless in Drosophila. In Drosophila, SetdB1 (Egg) is important for oogenesis and the silencing of chromosome 4.
Pfam PF00975: Thioesterase domain (domain)
Peptide synthetases are involved in the non-ribosomal synthesis of peptide antibiotics.  Next to the operons encoding these enzymes, in almost all cases, are genes that encode proteins that have similarity to the type II fatty acid thioesterases of vertebrates.  There are also modules within the peptide synthetases that also share this similarity. With respect to antibiotic production, thioesterases are required for the addition of the last amino acid to the peptide antibiotic, thereby forming a cyclic antibiotic. Thioesterases (non-integrated) have molecular masses of 25-29 kDa.
Pfam PF24643: Domain of unknown function (DUF7637) (domain)
This domain is found in uncharacterised proteins mainly from nematodes. It is predicted to adopt a globular structure consisting of a four-stranded antiparallel beta-sheet and two alpha-helices packed on one side of it.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF17210: SdrD B-like domain (domain)
This family corresponds to the B-like domain from the SdrD protein. This domain has three calcium binding sites within a greek key beta sandwich fold.
Pfam PF05144: Replication-associated protein G2P N-terminal (domain)
The phage replication protein CRI, also known as Replication-associated protein G2P or Gene II, is essential for DNA replication. This entry represents the N-terminal TBP-like domain, a DNA binding fold composed of a curved antiparallel beta-sheet.
Pfam PF07294: Fibroin P25 (family)
This family consists of several insect fibroin P25 proteins. Silk fibroin produced by the silkworm Bombyx mori consists of a heavy chain, a light chain, and a glycoprotein, P25. The heavy and light chains are linked by a disulfide bond, and P25 associates with disulfide-linked heavy and light chains by non-covalent interactions. P25 is plays an important role in maintaining integrity of the complex.
Wikipedia: Fibroin is an insoluble protein present in silk produced by numerous insects, such as the larvae of Bombyx mori, and other moth genera such as Antheraea, Cricula, Samia and Gonometa. Silk in its raw state consists of two main proteins, sericin and fibroin, with a glue-like layer of sericin coating two singular filaments of fibroin called brins. Silk fibroin is considered a β-keratin related to proteins that form hair, skin, nails and connective tissues.
Pfam PF10742: Protein of unknown function (DUF2555) (family)
This family is conserved in Cyanobacteria. The function is not known.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF21510: PirA-like (family)
This family includes PirA from Vibrio parahaemolyticus. PirA is a plasmid-encoded homolog of a Photorhabdus insect-related (Pir) protein. It folds into an eight-stranded antiparallel beta-barrel with jelly-roll topology.
Pfam PF04479: RTA1 like protein (family)
This family is comprised of fungal proteins with multiple transmembrane regions.  RTA1 ([swissprot:P53047]) is involved in resistance to 7-aminocholesterol, while RTM1 ([swissprot:P40113]) confers resistance to an an unknown toxic chemical in molasses.  These proteins may bind to the toxic substance, and thus prevent toxicity.  They are not thought to be involved in the efflux of xenobiotics.
Pfam PF07406: NICE-3 protein (family)
This family consists of several eukaryotic NICE-3 and related proteins. The gene coding for NICE-3 is part of the epidermal differentiation complex (EDC) which comprises a large number of genes that are of crucial importance for the maturation of the human epidermis. The function of NICE-3 is unknown.
Pfam PF03366: YEATS family (domain)
We have named this family the YEATS family, after `YNK7', `ENL', `AF-9', and `TFIIF small subunit'. This family also contains the GAS41 protein. All these proteins are thought to have a transcription stimulatory activity
Wikipedia: In molecular biology, the YEATS domain is a protein domain found in a variety of proteins from eukaryotic organisms. YEATS domain proteins are found in a variety of chromatin modification molecular complexes. Structurally the domain has an immunoglobulin like fold. The YEATS domain has shown to bind to acetyllysine protein modifications. In addition to lysine acetylation, the YEATS domain has shown to be a reader domain for various lysine acylations, with highest affinity for lysine crotonylation.
Pfam PF15692: NF-kappa-B-activating protein (family)
NKAP is a family of eukaryotic proteins that interacts with NF-kappa-B. It is a nuclear regulator of TNF- and IL-1-induced NF-kappa-B activation. NKAP does not interact with RIP in mammalian cells family is often found in association with [pfam:PF06047].
Pfam PF06543: Lactococcus bacteriophage repressor (family)
This family represents the C-terminus of Lactococcus bacteriophage repressor proteins.
Pfam PF00469: Negative factor, (F-Protein) or Nef (family)
Nef protein accelerates virulent progression of AIDS by its interaction with cellular proteins involved in signal transduction and host cell activation. Nef has been shown to bind specifically to a subset of the Src kinase family.
Wikipedia: Nef is a small 27-35 kDa myristoylated protein encoded by primate lentiviruses. These include Human Immunodeficiency Viruses and Simian Immunodeficiency Virus (SIV). Nef localizes primarily to the cytoplasm but also partially to the Plasma membrane (PM) and is one of many pathogen-expressed proteins, known as virulence factors, which function to manipulate the host's cellular machinery and thus allow infection, survival or replication of the pathogen. Nef stands for "Negative Factor" and although it is often considered indispensable for HIV-1 replication, in infected hosts the viral protein markedly elevates viral titers.
Pfam PF03078: ATHILA ORF-1 family (family)
ATHILA is a group of Arabidopsis thaliana retrotransposons belonging to the Ty3/gypsy family of the long terminal repeat (LTR) class of eukaryotic retrotransposons. The central region of ATHILA retrotransposons contains two or three open reading frames (ORFs). This family represents the ORF1 product. The function of ORF1 is unknown.
Pfam PF01326: Pyruvate phosphate dikinase, AMP/ATP-binding domain (family)
This enzyme catalyses the reversible conversion of ATP to AMP, pyrophosphate and phosphoenolpyruvate (PEP). The N-terminal domain has been shown to be the AMP/ATP-binding domain.
Wikipedia: Pyruvate, phosphate dikinase, or PPDK is an enzyme in the family of transferases that catalyzes the chemical reactionATP + pyruvate + phosphate  AMP + phosphoenolpyruvate + diphosphate
Pfam PF04983: RNA polymerase Rpb1, domain 3 (domain)
RNA polymerases catalyse the DNA dependent polymerisation of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases).  This domain, domain 3, represents the pore domain. The 3' end of RNA is positioned close to this domain. The pore delimited by this domain is thought to act as a channel through which nucleotides enter the active site and/or where the 3' end of the RNA may be extruded during back-tracking.
Pfam PF21415: SMK1 alpha subunit (family)
The killer toxin SMK (salt-mediated killer) from the halotolerant yeast Pichia farinosa acts to kill sensitive strains of yeast. SMK exhibits maximum activity under conditions of acidic pH and high salt concentration. It is composed of two distinct subunits, alpha and beta, which tightly interact with each other under acidic conditions, jointly folding into an ellipsoidal single domain structure belonging to the alpha/beta-sandwich family. SMK assumes a similar folding topology to the fungal killer toxin KP4, forming two left-handed split beta/alpha/beta motifs which is rarely found in other toxins; hence, these toxins may be evolutionarily or functionally related. SMK appears to function by associating with the membranes of sensitive cells. This entry represents SMK alpha subunit.