SII-SWORD/CoKE huggingface dataset:
Pfam PF09185: Domain of unknown function (DUF1948) (domain)
Members of this family of Mycoplasma hypothetical proteins adopt a helical structure, with one central alpha-helix surrounded by five others, in a NusB-like fold. Their function has not, as yet, been determined.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF09912: Uncharacterized protein conserved in bacteria (DUF2141) (family)
This domain, found in various hypothetical prokaryotic proteins, has no known function.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF01718: Orbivirus non-structural protein NS1, or hydrophobic tubular protein (family)
This family consists of orbivirus non-structural protein NS1, or hydrophobic tubular protein. NS1 has no specific function in virus replication, it is however thought to play a role in transport of mature virus particles from virus inclusion bodies to the cell membrane. Orbivirus are part of the larger reoviridae which have a dsRNA genome of at least 10 segments encoding at least 10 viral proteins; orbivirus found in this family include  bluetongue virus, and African horsesickness virus.
Pfam PF23712: Monkey King C-terminal KA1 domain (domain)
This entry represents the C-terminal domain of a family of proteins largely found in Drosphilidae species. This domain structurally resembles the KA1 domain [pfam:PF02149]. This domain is found in the Monkey King proteins. Monkey King is a Drosophilidae-specific protein that emerged from duplication and divergence of the ancestral TUTase6 gene.
Pfam PF16487: Mid domain of argonaute (domain)
The ArgoMid domain is found to be part of the Piwi-lobe of the argonaute proteins. It is composed of a parallel four-stranded beta-sheet core surrounded by four alpha-helices and two additional short alpha-helices. It most closely resembles the amino terminal tryptic core of the E.coli lactose repressor. There is an extensive interface between the Mid and the Piwi domains. The conserved C-terminal half or the Mid has extensive interactions with Piwi, with a deep basic pocket on the surface of the `Mid adjacent to the interface with Piwi. The Mid carries a binding pocket for the 5' phosphate overhang of the guide strand of DNA.  The N, Mid, and Piwi domains form a base upon which the PAZ domain sits, resembling a duck. The 5' phosphate and the U1 base are held in place by a conserved network of interactions from protein residues of the Mid and Piwi domains in order to place the guide uniquely in the proper position observed in all Argonaute-RNA complexes.
Pfam PF14311: Probable Treble clef zinc finger domain (family)
This domain is found in bacteria, eukaryotes and viruses, and is approximately 60 amino acids in length. It contains a CXXCXH motif and a CPXC motif. It is predicted to adopt treble clef fold. Some members have the second probable zinc binding residue replaced by histidine.
Pfam PF04388: Hamartin protein (family)
This family includes the hamartin protein which is thought to function as a tumour suppressor.  The hamartin protein interacts with the tuberin protein [pfam:PF03542]. Tuberous sclerosis complex (TSC) is an autosomal dominant disorder and is characterised by the presence of hamartomas in many organs, such as brain, skin, heart, lung, and kidney. It is caused by mutation either TSC1 or TSC2 tumour suppressor gene. TSC1 encodes a protein, hamartin, containing two coiled-coil regions, which have been shown to mediate binding to tuberin. The TSC2 gene codes for tuberin [pfam:PF03542]. These two proteins function within the same pathway(s) regulating cell cycle, cell growth, adhesion, and vesicular trafficking.
Pfam PF23915: Alpha-amylase SusG C-terminal domain (domain)
This entry represents the C-terminal domain found in the starch utilization system protein G (SusG) from bacteria. SusG forms part of the SusDEFG lipoprotein complex tethered to the outer surface of the cell and is involved in starch hydrolysis and subsequent utilization of the resulting sugars as an energy source. SusG has been shown to have enzymatic starch-hydrolysing activity. This entry also represents the C-terminal domain of other oligo-1,6-glucosidases, such as the trehalose-6-phosphate hydrolase TreA, glucan 1,6-alpha-glucosidase dexB and  Oligo-1,6-glucosidase 1 malL from bacteria. The function of this domain is unknown.
Pfam PF19376: Family of unknown function (DUF5951) (family)
This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0001805) is described by MIBiG as an example of the following biosynthetic class, NRP (non-ribosomal peptide).
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF07951: Clostridium neurotoxin, C-terminal receptor binding (domain)
The Clostridium neurotoxin family is composed of tetanus neurotoxins and seven serotypes of botulinum neurotoxin. The structure of the botulinum neurotoxin reveals a four domain protein.  The N-terminal catalytic domain ([pfam:PF01742]), the central translocation domains and two receptor binding domains.  This domains is the C-terminal receptor binding domain, which adopts a modified beta-trefoil fold with a six stranded beta-barrel and a beta-hairpin triplet capping the domain. The first step in the intoxication process is a binding event between this domains and the pre-synaptic nerve ending.
Pfam PF16579: Adenylate sensor of SNF1-like protein kinase (domain)
AdenylateSensor is a family found at the C-terminus of SNF1-like protein kinases snf other protein-kinases.
Pfam PF06985: Heterokaryon incompatibility protein (HET) (domain)
This family represents a conserved region approximately 150 residues long within various heterokaryon incompatibility proteins mainly found in ascomycete fungi. Genetic differences in specific het genes prevent a viable heterokaryotic fungal cell from being formed by the fusion of filaments from two different wild-type strains. Many family members also contain the [pfam:PF00400] repeat and the  [pfam:PF05729] domain.
Pfam PF00763: Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain (domain)
This entry represents the N-terminal catalytic domain of enzymes that belong to the tetrahydrofolate dehydrogenase/cyclohydrolase family, which are mainly found in bacteria but also in archaeal and eukaryotic organisms.
Enzymes that participate in the transfer of one-carbon units require the coenzyme tetrahydrofolate (THF). Various reactions generate one-carbon derivatives of THF, which can be interconverted between different oxidation states by methylene-THF dehydrogenase (1.5.1.5), methenyl-THF cyclohydrolase (3.5.4.9) and formyl-THF synthetase (6.3.4.3) . The dehydrogenase and cyclohydrolase activities are expressed by a variety of multifunctional enzymes, including the tri-functional eukaryotic C1-tetrahydrofolate synthase ; a bifunctional eukaryotic mitochondrial protein; and the bifunctional Escherichia coli folD protein . Methylene-tetrahydrofolate dehydrogenase and methenyltetrahydrofolate cyclo-hydrolase share an overlapping active site , and as such are usually located together in proteins, acting in tandem on the carbon-nitrogen bonds of substrates other than peptide bonds.
Pfam PF09657: CRISPR-associated protein Csx8 (Cas_Csx8) (family)
Clusters of short DNA repeats with nonhomologous spacers, which are found at regular intervals in the genomes of phylogenetically distinct prokaryotic species, comprise a family with recognisable features. This family is known as CRISPR (short for Clustered, Regularly Interspaced Short Palindromic Repeats). A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This entry describes proteins of unknown function which are encoded in the midst of a cas gene operon.
Pfam PF17179: 4Fe-4S dicluster domain (domain)
Ferredoxins are a group of iron-sulphur proteins which mediate electron transfer in a wide variety of metabolic reactions. Ferredoxins can be divided into several subgroups depending upon the physiological nature of the iron-sulphur cluster(s). One of these subgroups are the 4Fe-4S ferredoxins, which are found in bacteria and which are thus often referred as 'bacterial-type' ferredoxins. The structure of these proteins  consists of the duplication of a domain of twenty six amino acid residues; each of these domains contains four cysteine residues that bind to a 4Fe-4S centre.

Several structures of the 4Fe-4S ferredoxin domain have been determined . The clusters consist of two interleaved 4Fe- and 4S-tetrahedra forming a cubane-like structure, in such a way that the four iron occupy the eight corners of a distorted cube. Each 4Fe-4S is attached to the polypeptide chain by four covalent Fe-S bonds involving cysteine residues.

A number of proteins have been found  that include one or more 4Fe-4S binding domains similar to those of bacterial-type ferredoxins.

The pattern of cysteine residues in the iron-sulphur region is sufficient to detect this class of 4Fe-4S binding proteins. This entry represents the whole domain.

Note: In some bacterial ferredoxins, one of the two duplicated domains has lost one or more of the four conserved cysteines. The consequence of such variations is that these domains have either lost their iron-sulphur binding property or bind to a 3Fe-3S centre instead of a 4Fe-4S centre.
Wikipedia: 
Iron–sulfur proteins are proteins characterized by the presence of iron–sulfur clusters containing sulfide-linked di-, tri-, and tetrairon centers in variable oxidation states. Iron–sulfur clusters are found in a variety of metalloproteins, such as the ferredoxins, as well as NADH dehydrogenase, hydrogenases, coenzyme Q – cytochrome c reductase, succinate – coenzyme Q reductase and nitrogenase. Iron–sulfur clusters are best known for their role in the oxidation-reduction reactions of electron transport in mitochondria and chloroplasts. Both Complex I and Complex II of oxidative phosphorylation have multiple Fe–S clusters. They have many other functions including catalysis as illustrated by aconitase, generation of radicals as illustrated by SAM-dependent enzymes, and as sulfur donors in the biosynthesis of lipoic acid and biotin. Additionally, some Fe–S proteins regulate gene expression. Fe–S proteins are vulnerable to attack by biogenic nitric oxide, forming dinitrosyl iron complexes. In most Fe–S proteins, the terminal ligands on Fe are thiolate, but exceptions exist.
Pfam PF07580: M26 IgA1-specific Metallo-endopeptidase C-terminal region (family)
These peptidases, which cleave mammalian IgA, are found in Gram-positive bacteria. Often found associated  with [pfam:PF00746], they may be attached to the cell wall.
Pfam PF17754: MftR C-terminal domain (domain)
This domain is found at the C-terminus of TetR like transcription factors including the Mycofactin biosynthesis transcription factor.
Pfam PF11290: Protein of unknown function (DUF3090) (family)
This family of proteins with unknown function appears to be restricted to Actinobacteria.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF08659: KR domain (family)
This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group.
Pfam PF24033: Family of unknown function (DUF7342) (family)
This family includes uncharacterised archaeal proteins that contain a HTH domain.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF05605: Drought induced 19 protein (Di19), zinc-binding (domain)
This family consists of several drought induced 19 (Di19) like proteins. Di19 has been found to be strongly expressed in both the roots and leaves of Arabidopsis thaliana during progressive drought. This domain is a zinc-binding domain.
Pfam PF19657: Family of unknown function (DUF6160) (family)
This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 153 and 460 amino acids in length.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF18554: PheRS DNA binding domain 2 (domain)
This is a DNA-binding fold domain found in Phenylalanyl-tRNA Synthetase N-terminal region. Mutational analysis indicate that DBD-1, 2 and 3 play critical roles in tRNA- Phe binding and recognition, i.e., from the drastic reduction of aminoacylation activity seen upon removal of the N-terminal domains. DBD-2 and DBD-3 constitute large insertions sequentially included between two neighboring antiparallel strands of the DBD-1 domain. Moreover, the DBD-3 [pfam:PF18553] is the domain insertion into DBD-2.
Pfam PF24042: Domain of unknown function (DUF7351) (domain)
This is a presumed domain found at the C-terminal of a group of uncharacterised archaeal sequences, which contain an HTH domain at the N-terminal.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF17397: TSX (family)
This is a family of unknown function found in Chordata. This domain is located downstream the N-terminal of Fip1 [pfam:PF05182]. Family members such as [swissprot:P70537] and [swissprot:P70675] contain this domain. The Tsx gene resides at the X-inactivation centre and once thought to encode a protein expressed in testis. However, this was disputed upon further analysis. ORF and immunostaining analysis concluded that Tsx may be non-coding. Tsx long transcript is abundantly expressed in meiotic germ cells, embryonic stem cells, and brain. In vertebrates, Fip1 is the evolutionary precursor of eutherian Tsx, hence its location upstream from the Tsx gene.
Pfam PF13898: Deubiquitinating enzyme MINDY-3/4, conserved domain (domain)
Deubiquitinating enzymes (DUBs) remove ubiquitin (Ub) from Ub-conjugated substrates to regulate the functional outcome of ubiquitination. This entry includes MINDY-3/4. They belong to the MINDY (motif interacting with Ub-containing novel DUB) family (peptidase family C121), whose members are deubiquitinating enzymes releasing Lys48-linked ubiquitin. This is a conserved domain found in deubiquitinating enzymes, MINDY-3 and MINDY-4.
Pfam PF04412: Aconitase X (family)
Aconitase X (AcnX) is a subfamily of Acn superfamily. It is encoded in the genomes of many archaea, proteobacteria and fungi. Among archaea, the pattern of aconitase X occurrence complements that of aconitase A such that together the two enzymes account for aconitase activity in all archaea. This protein catalyzes the dehydration of cis-3-hydroxy-L-proline to delta1-pyrroline-2-carboxylate.
Wikipedia: Aconitase is an enzyme that catalyses the stereo-specific isomerization of citrate to isocitrate via cis-aconitate in the tricarboxylic acid cycle, a non-redox-active process.
Pfam PF03070: TENA/THI-4/PQQC family (family)
Members of this family are found in all the three major phyla of life: archaebacteria, eubacteria, and eukaryotes. In Bacillus subtilis, TENA is one of a number of proteins that enhance the expression of extracellular enzymes, such as alkaline protease, neutral protease and levansucrase.  The THI-4 protein, which is involved in thiamine biosynthesis, is also a member of this family. The C-terminal part of these proteins consistently show significant sequence similarity to TENA proteins. This similarity was first noted with the Neurospora crassa THI-4. This family includes bacterial coenzyme PQQ synthesis protein C or PQQC proteins.  Pyrroloquinoline quinone (PQQ) is the prosthetic group of several bacterial enzymes,including methanol dehydrogenase of methylotrophs and the glucose dehydrogenase of a number of bacteria. PQQC has been found to be required in the synthesis of PQQ but its function is unclear.  The exact molecular function of members of this family is uncertain.
Pfam PF02341: RbcX protein (family)
The RBCX protein has been identified as having a possible chaperone-like function.  The rbcX gene is juxtaposed to and cotranscribed with rbcL and rbcS encoding RuBisCO in Anabaena sp. CA. RbcX has been shown to possess a chaperone-like function assisting correct folding of RuBisCO in E. coli expression  studies and is needed for RuBisCO to reach its maximal activity.
Pfam PF16606: Unstructured conserved, between two C2H2-type zinc-fingers (disordered)
This domain is found on a set of eukaryotic Zinc finger protein 536 transcriptional regulator proteins sandwiched between zf-C2H2, [pfam:PF00096] and zf-H2C2_2 [pfam:PF13465]. It is not conserved between other pairs of the zinc-fingers on these sequences. It is natively unstructured, and its function is not known. The proteins recognise and bind 2 copies of the core DNA sequence 5'-CCCCCA-3'.
Pfam PF15651: Salivary glad secreted protein domain toxin (family)
An alpha+beta fold domain with four conserved cysteine residues and a conserved [DE}xx[ND] motif. This domain is mainly present at the c-terminus of RHS repeats containing proteins in insects and crustaceans. Although no bacterial homologs have been identified, the domain architecture suggests an origin from bacterial polymorphic toxin systems.
Pfam PF20361: Family of unknown function (DUF6656) (family)
This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 200 amino acids in length.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF14344: Domain of unknown function (DUF4397) (family)
This presumed domain is functionally uncharacterised. This domain family is found in bacteria, archaea and eukaryotes, and is approximately 120 amino acids in length.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF24259: Domain of unknown function (DUF7460) (domain)
This entry represents a small uncharacterised mycobacterial phage domain composed of two alpha helices and three beta strands. The family includes Phage Bxb1 gene 81.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF03211: Pectate lyase (repeat)
Pectate lyase is responsible for the maceration and soft-rotting of plant tissue. It catalyses the eliminative cleavage of pectate to produce oligosaccharides with 4-deoxy-alpha-D-gluc-4-enuronosyl groups at their non-reducing ends. Pectate lyase is an extracellular enzyme and is induced by pectin. It is subject to self-catabolite repression, and has been implicated in plant disease.

This entry represents a group of pectate lyases, including PlyE and PlyH from Aspergillus nidulans .
Pfam PF25140: GPI inositol-deacylase transmembrane domain (domain)
This domain is found in GPI inositol-deacylase (BST1 also known as PGAP1) and related proteins. PGAP1 is involved in inositol deacylation of GPI-anchored proteins. This deacylation is important for the efficient transport of GPI-anchored proteins from the endoplasmic reticulum to the Golgi body. This entry represents the transmembrane domain which consists of 10 transmembrane helices that are mostly perpendicular to the membrane, with the exception of a long TMH4 which  crosses the membrane diagonally.
Pfam PF24108: Family of unknown function (DUF7383) (family)
This entry represents a group of uncharacterised archaeal sequences containing a galactose binding-like domain.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.