SII-SWORD/CoKE huggingface dataset:
Pfam PF11850: Protein of unknown function (DUF3370) (family)
This family of proteins are functionally uncharacterised. This protein is found in bacteria. Proteins in this family are typically between 452 to 532 amino acids in length.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF15079: Testis-specific protein 35 (family)
Tsc35 (also referred to in the literature as Tsc24) is essential for spermatogenesis in mammalian male reproduction. It is expressed in the testis from day 35 onwards in mice.
Pfam PF06082: Exopolysaccharide biosynthesis protein YbjH (family)
YjbH is a family of Gram-negative beta-barrel outer-membrane lipoproteins that act as putative porins. YbjH is one of four gene-products expressed from an operon, yjbEFGH, which is regulated by the Rcs phosphorelay in a RcsA-dependent manner, similar to that of other exopolysaccharide biosynthetic pathways. It is highly possible that the yjbEFGH operon encodes a system involved in EPS secretion since none of the products is predicted to have enzymic activity, the products are all secreted and YbjH and F are predicted to be beta-barrel lipoproteins similar to porins. It may be that the operon products play some role in biofilm formation and/or matrix production.
Pfam PF11013: Protein of unknown function (DUF2851) (family)
This bacterial family of proteins has no known function.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF17035: Bromodomain extra-terminal - transcription regulation (domain)
The BET, or bromodomain extra-terminal domain, is found on bromodomain proteins that play key roles in development, cancer progression and virus-host pathogenesis. It interacts with NSD3, JMJD6, CHD4, GLTSCR1, and ATAD5 all of which are shown to impart a pTEFb-independent transcriptional activation function on the bromodomain proteins.
Pfam PF24065: DNA polymerase zeta catalytic subunit, N-terminal (domain)
This domain is found at the N-terminal end of DNA polymerase zeta catalytic subunit (REV3) from Saccharomyces cerevisiae and similar eukaryotic sequences. REV3 is a nonessential DNA polymerase involved in DNA repair, mitochondrial DNA repair and translesion synthesis. This domain shows a mainly beta- configuration. It is often found N-terminal to [pfam:PF24055].
Pfam PF01304: Gas vesicles protein GVPc repeated domain (repeat)
Gas vesicles are small, hollow, gas filled protein structures found in several cyanobacterial and archaebacterial microorganisms . They allow the positioning of the bacteria at the favorable depth for growth. Gas vesicles are hollow cylindrical tubes, closed by a hollow, conical cap at each end. Both the conical end caps and central cylinder are made up of 4-5 nm wide ribs that run at right angles to the long axis of the structure. Gas vesicles seem to be constituted of two different protein components: GVPa and GVPc. GVPc is a minor constituent of gas vesicles and seems to be located on the outer surface. Structurally, cyanobacterial GVPc consists of four or five tandem repeats of a 33 residue sequence flanked by sequences of 18 and 10 residues at the N- and C-termini, respectively.
Pfam PF08149: BING4CT (NUC141) domain (repeat)
This C terminal domain is found in the BING4 family of nucleolar WD40 repeat proteins.
Pfam PF11375: Protein of unknown function (DUF3177) (family)
Some members in this family of proteins are annotated as membrane proteins however this cannot be confirmed. Currently there is no known function.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF11098: Chlorosome envelope protein C (family)
Chlorosomes are light-harvesting antennae found in green bacteria. CsmC is one of the proteins that exists in the chlorosome envelope. CsmC has been shown to exist as a homomultimer with CsmD in the chlorosome envelope. CsmC is thought to be important in chlorosome elongation and shape.
Pfam PF15870: ElonginA binding-protein 1 (family)
This domain family is found in eukaryotes, and is typically between 144 and 167 amino acids in length.
Pfam PF23059: M02D8_5-like, sixth CUB domain (domain)
This entry represents the sixth occurrence of the CUB domain in a family of uncharacterised proteins present in nematodes. Consecutive repetitions of this domain are common in this protein family. The CUB domain (for complement C1r/C1s, Uegf, Bmp1) is a structural motif of approximately 110 residues found predominantly in extracellular and plasma membrane-associated proteins, many of which undergo developmental regulation. CUB domains appear to be involved in oligomerisation and/or recognition of substrates and binding  partners.
Pfam PF01867: CRISPR associated protein Cas1 (family)
Clustered regularly interspaced short palindromic repeats (CRISPRs) are a family of DNA direct repeats found in many prokaryotic genomes. This family of proteins corresponds to Cas1, a CRISPR-associated protein.  Cas1 may be involved in linking DNA segments to CRISPR.
Wikipedia: CRISPR-associated protein 1 (cas1) is one of the two universally conserved proteins found in the CRISPR prokaryotic immune defense system. Cas1 is a metal-dependent DNA-specific endonuclease that produces double-stranded DNA fragments. Cas1 forms a stable complex with the other universally conserved CRISPR-associated protein, cas2, which is essential to spacer acquisition for CRISPR systems.
Pfam PF09808: Small nuclear RNA activating complex (SNAPc), subunit 1 (family)
Members of this family are part of the SNAPc complex (SNAPC1) required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. They bind to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes.  Furthermore, they also recruit TBP and BRF2 to the U6 snRNA TATA box.
Pfam PF23653: Domain of unknown function (DUF7149) (domain)
This domain is found in related bacterial proteins. It is predicted to adopt an alpha/beta globular structure and shares significant sequence and structural similarity to members of PD-(D/E)XK nuclease superfamily, in particular, BpuSI N-terminal nuclease domain ([pfam:PF15516]).
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF16639: Apocytochrome F, N-terminal (domain)
This is the N-terminal domain of cytochrome f. It is a soluble lumen-side domain.
Pfam PF05396: Phage T7 capsid assembly protein (family)
This family includes the capsid assembly protein Gp9 (scaffolding protein) of bacteriophage T7, similar viral proteins and prophages from Proteobacteria. Gp9 facilitates assembly by binding to Gp10 hexamers but not the pentamers and locking them into a morphogenically correct conformation .
Pfam PF22352: K319L-like, PKD domain (domain)
This entry represents the PKD domain of Dyslexia-associated protein KIAA0319-like protein, in which it is found in four copies. This entry also includes Kunitz-type protease inhibitor 1 and LRP11 from human.
Pfam PF12598: T-box transcription factor 2/3, TAD domain (domain)
This domain is found in T-box transcription factors 2 and 3, and is typically between 77 and 89 amino acids in length. This domain is found C-terminal of the T-box DNA binding domain ([pfam:PF00907]). This may be a transcription activation domain (TAD) and there are two completely conserved residues (S and P) that may be functionally important. T-box genes encode transcription factors involved in morphogenesis and organogenesis of vertebrates and invertebrates.
Pfam PF11770: GRB2-binding adapter (GAPT) (family)
This is a family of transmembrane proteins which bind the growth factor receptor-bound protein 2 (GRB2) in B cells.  In contrast to other transmembrane adaptor proteins, GAPT is not phosphorylated upon BCR ligation.  It associates with GRB2 constitutively through its proline-rich region.
Pfam PF17072: Torovirinae spike glycoprotein (family)
The spike glycoprotein is a corona viral transmembrane protein that mediates the binding of virions to the host cell receptor and is involved in membrane fusion. The torovirinae spike proteins appear distinct from other coronaviridae spike proteins, such as human SARS coronavirus. This entry also includes some alloherpesvirus fusion glycoproteins.
Pfam PF21256: Tetracyclin repressor-like, C-terminal domain (domain)
This domain is found at the C-terminal end of Transcriptional regulator, TetR family from Thermotoga maritima (TM_1030) and similar sequences from bacteria. TM_1030 shows high similarity to members of the TetR family at the N-terminal DNA-binding domain ([pfam:PF00440]). However, differences are much greater in the C-terminal regulatory domain, which shows an all-helical structure.
Pfam PF22537: Polysaccharide deacetylase (family)
This family represents a group of bacterial proteins, including the putative polysaccharide deacetylase WbmS from Bordetella bronchiseptica, which is involved in O-antigen biosynthesis. It adopts an alpha-beta barrel configuration.
Pfam PF21921: Ski7 domain II (domain)
This entry represents the Ski7 II domain, which is a component of the C-terminal region of the Ski7 protein in budding yeast. Ski7 is a cofactor of the cytoplasmic exosome that functions in mRNA turnover and non-stop decay (NSD). The Ski7 II domain shares overall sequence similarity with the translational GTPase (trGTPase) Hbs1, but unlike other trGTPases, Ski7 might function as a GTP-binding protein rather than a GTP-hydrolyzing enzyme. The Ski7C is organized into three domains, with domain I adopting the alpha beta fold of GTP-binding domains, and domains II and III each adopting the structure of a closed beta barrel. Domains II and III appear to form a single unit and interact with the G domain, and the three domains interact intra-molecularly not only via their globular folds but also via extended segments.
Pfam PF15764: Domain of unknown function (DUF4693) (family)
This family of proteins is found in eukaryotes. Proteins in this family are typically between 238 and 436 amino acids in length.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF15055: Domain of unknown function (DUF4536) (domain)
This domain family is thought to be a transmembrane helix. It is found in eukaryotes, and is approximately 50 amino acids in length.  In humans, it is located in the chromosomal position, C9orf123. The family contains the uncharacterised Sch. pombe protein TAM6 which is found in the mitochondrion.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF19067: Family of unknown function (DUF5763) (family)
This is a family of uncharacterised proteins of unknown function found predominantly in viruses. However, some matches with predicted proteins from Archaea and  Eukaryotes were also found.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF14794: Domain of unknown function (DUF4479) (family)
This domain family is found in bacteria, and is approximately 70 amino acids in length. The family is found in association with [pfam:PF01588].
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF17746: SfsA N-terminal OB domain (domain)
This family contains Sugar fermentation stimulation proteins. Which is probably a regulatory factor involved in maltose metabolism. This domain corresponds to the N-terminal OB fold.
Pfam PF00146: NADH dehydrogenase (family)
This entry represents subunit 1 NADH:ubiquinone oxidoreductase . Among the many polypeptide subunits that make up complex I, there are fifteen which are located in the membrane part, seven of which are encoded by the mitochondrial and chloroplast genomes of most species. The most conserved of these organelle-encoded subunits is known as subunit 1 (gene ND1 in mitochondrion, and NDH1 in chloroplast) and seems to contain the ubiquinone binding site.

The ND1 subunit is highly similar to subunit 4 of Escherichia coli formate hydrogenlyase (gene hycD), subunit C of hydrogenase-4 (gene hyfC). Paracoccus denitrificans NQO8 and Escherichia coli nuoH NADH-ubiquinone oxidoreductase subunits also belong to this family .
This entry also includes the archaeal F420H2 oxidoreductase subunit H (FPO). FPO shuttles electrons from F420H2, via FAD and iron-sulphur (Fe-S) centres, to quinones in the F420H2:heterodisulphide oxidoreduction chain. The immediate electron acceptor for the enzyme in this species is believed to be methanophenazine. Couples the redox reaction to proton translocation (for every two electrons transferred, 0.9 hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
Wikipedia: Respiratory complex I, EC 7.1.1.2 is the first large protein complex of the respiratory chains of many organisms from bacteria to humans. It catalyzes the transfer of electrons from NADH to coenzyme Q10 (CoQ10) and translocates protons across the inner mitochondrial membrane in eukaryotes or the plasma membrane of bacteria.
Pfam PF05380: Pao retrotransposon peptidase (family)
Corresponds to Merops family A17. These proteins are homologous to aspartic proteinases encoded by retroposons and retroviruses.
Pfam PF12353: Eukaryotic translation initiation factor 3 subunit G (family)
This domain family is found in eukaryotes, and is approximately 130 amino acids in length. The family is found in association with [pfam:PF00076]. This family is subunit G of the eukaryotic translation initiation factor 3. Subunit G is required for eIF3 integrity.
Pfam PF19126: Family of unknown function (DUF5810) (family)
This is a family of proteins of unknown function predominantly found in Halobacteria, but also in Eukaryotes. This family contains some members that are predicted as C2H2-type domain-containing proteins.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF25061: Fungal RNA-binding domain (domain)
This is a RNA-binding domain, also known as RNA recognition motif (RRM) found in a group of uncharacterised proteins from fungi.
Pfam PF08786: DcrB (domain)
DcrB is a bacterial protein required for phages C1 and C6 adsorption. It may be involved in the opening or formation of diffusion channels in the outer membrane. Structurally, it consist of an antiparallel beta sheet with some alpha helical regions.
Pfam PF12866: Protein of unknown function (DUF3823) N-terminal domain (domain)
This is a family of uncharacterised proteins from Bacteroidetes. This domain has a beta-sandwich prealbumin-like fold.
Pfam PF18732: HEPN like, Abia C-terminal domain (domain)
AbiA-CTD-like HEPN nuclease. Fused to Reverse Transcriptase ; in operon with R-M system.
Pfam PF16107: Domain of unknown function (DUF4825) (domain)
This domain forms the N-terminal, extracellular domain of some homologs of Staph BlaR1 proteases, where it replaces the penicillin-binding domain of BlaR1. It is also found in many uncharacterised proteins in a broad range of bacteria. Its association with BlaR1 homologues suggests it may be involved in substrate-, possibly antibiotic-binding, but this prediction has not been verified experimentally.
Pfam PF18720: Tenascin EGF domain (domain)
This entry represents the EGF-like domains found in tenascin proteins.
Pfam PF22336: RhiE-like, KS-MAT linker domain (domain)
This entry represents a linker domain found in polyketide synthases, which connects the N-terminal domains with the B-domain as described in RhiE.
Pfam PF12532: Protein of unknown function (DUF3732) (family)
This domain family is found in bacteria and eukaryotes, and is typically between 180 and 198 amino acids in length. There is a conserved DQP sequence motif.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF16119: Domain of unknown function (DUF4835) (family)
This family consists of uncharacterized proteins of around 300 residues in length and is mainly found in bacteria from the Cytophaga-Flavobacteria-Bacteroides (CFB) group, both environmental and from human microbiome. The function of this family is unknown.
Pfam PF11811: Domain of unknown function (DUF3331) (family)
This family of proteins are functionally uncharacterised. This family is only found in bacteria. Proteins in this family vary in length from 96 to 160 amino acids.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF22468: ACT domain (domain)
This entry represents the ACT domain, which is found twice in Aspartate kinase from Methanocaldococcus jannaschii, the enzyme that catalyses the phosphorylation of aspartic acid. This domain folds as a four-stranded antiparallel sheet with two alpha-helices parallel to the sheet and located on one side of the sheet.
Pfam PF01107: Viral movement protein (MP) (family)
This family includes a variety of movement proteins (MP)s. The MP is necessary for the initial cell-to-cell movement during the early stages of a viral infection.  This movement is active, and it is known that the MP interacts with the plasmodesmata and possesses the ability to bind to RNA to achieve its role. This family also includes consists of virus movement proteins from the caulimovirus family. It has been suggested in cauliflower mosaic virus that these proteins mediated viral movement by modifying plasmodesmata and forming tubules in the channel that can accommodate the virus particles and references therein. The family contains a conserved DXR motif that is probably functionally important.
Pfam PF10921: Protein of unknown function (DUF2710) (family)
This family of proteins with unknown function appears to be restricted to Mycobacteriaceae.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF24855: Domain of unknown function (DUF7729) (domain)
This domain is found in uncharacterised fungal proteins. It is predicted to adopt a globular structure consisting of array of alpha helices. It contains several conserved cysteine residues that are predicted to form disulfide bonds. It is likely that the proteins containing this domain are secreted.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF25063: Tetratricopeptide repeat protein 21 C-terminal ARM domain (repeat)
This entry represents the C-terminal ARM-repeats domain of Tetratricopeptide repeat protein 21 (TT21) from human and its homologues. TT21 is an intraflagellar transport (IFT)-associated protein required for spermatogenesis. It is involved in sperm flagellar formation and intraflagellar transport.
Pfam PF01255: Putative undecaprenyl diphosphate synthase (family)
Previously known as uncharacterized protein family UPF0015, a single member of this family [swissprot:O82827] has been identified as an undecaprenyl diphosphate synthase.