SII-SWORD/CoKE huggingface dataset:
Pfam PF20352: Domain of unknown function (DUF6647) (domain)
This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 158 and 180 amino acids in length. Proteins in this family have a metzincin-like fold and are most closely related to the structure of the YbeY endoribonuclease proteins.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF14539: Domain of unknown function (DUF4442) (domain)
This family of proteins is found in bacteria, archaea and eukaryotes.  Proteins in this family are typically between 139 and 165 amino acids in length.  There is a conserved PYF sequence motif. There is a single completely conserved residue N that may be functionally important.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF06983: 3-demethylubiquinone-9 3-methyltransferase (family)
This family represents a conserved region approximately 100 residues long within a number of bacterial and archaeal 3-demethylubiquinone-9 3-methyltransferases ([ec:2.1.1.64]). Note that some family members contain more than one copy of this region, and that many members are hypothetical proteins.
Pfam PF17565: Family of unknown function (DUF5471) (family)
This is a family of unknown function found in Enterobacteria phage T7.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF14576: Sieve element occlusion N-terminus (family)
Sieve element occlusion (SEO) proteins, or forisomes, are phloem proteins which accumulate during sieve element differentiation. This domain represents the N-terminus of SEO proteins.
Pfam PF10725: Protein of unknown function (DUF2517) (family)
This family is conserved in Proteobacteria. Several members are annotated as being protein YbfA. The function is not known.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF21694: DNA polymerase III delta subunit, C-terminal domain (domain)
This entry represents the C-terminal domain of the delta subunit from the clamp-loader complex of Bacillus subtilis and other Gram-positive bacteria, which is structurally similar to that of the DNApol3 delta subunit from E.coli. This domain interacts with other subunits in the complex (tau and delta') and the nature of these interactions appear to be hydrophilic in contrast with the one observed in Gram-negative bacteria.
Pfam PF07017: Antimicrobial peptide resistance and lipid A acylation protein PagP (family)
This family consists of several bacterial antimicrobial peptide resistance and lipid A acylation (PagP) proteins. The bacterial outer membrane enzyme PagP transfers a palmitate chain from a phospholipid to lipid A. In a number of pathogenic Gram-negative bacteria, PagP confers resistance to certain cationic antimicrobial peptides produced during the host innate immune response.
Wikipedia: Antimicrobial peptide resistance and lipid A acylation protein PagP 
is a family of several bacterial antimicrobial peptide resistance and lipid A acylation (PagP) proteins. The bacterial outer membrane enzyme PagP transfers a palmitate chain from a phospholipid to lipid A. In a number of pathogenic Gram-negative bacteria, PagP confers resistance to certain cationic antimicrobial peptides produced during the host innate immune response.
Pfam PF20051: Family of unknown function (DUF6453) (family)
This family of uncharacterised proteins is mainly found in phages. It may represent structural phage proteins. There are several conserved motifs: FxxI, GxxxxP and FSxxxxP, and also 7 additional conserved Glycine residues.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF04945: YHS domain (domain)
This short presumed domain is about 50 amino acid residues long. It often contains two cysteines that may be functionally important.  This domain is found in copper transporting ATPases, some phenol hydroxylases and in a set of uncharacterised membrane proteins including [swissprot:Q9CNI0]. This domain is named after three of the most conserved amino acids it contains.  The domain may be metal binding, possibly copper ions. This domain is duplicated in some copper transporting ATPases.
Pfam PF14470: Bacterial PH domain (domain)
Proteins in this family are distantly related to PH domains.
Pfam PF11827: Protein of unknown function (DUF3347) (domain)
This entry represents a functionally uncharacterised  domain found in bacterial proteins.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF19059: Family of unknown function (DUF5755) (family)
This family of unknown function appears to be primarily restricted to mimiviridae and phycodnaviridae. This entry may be found at the N terminus of longer proteins, which contain a C-terminal DNA polymerase family domain and a DNA polymerase family B exonuclease domain.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF24288: Family of unknown function (DUF7476) (family)
This family includes a group of proteins from nematodes.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF22342: T3SS, Low calcium response E, third helical domain (domain)
This domain is found in Low calcium response E from Chlamydia pneumoniae (CopN, also known as LcrE) and similar bacterial sequences. CopN is involved in the regulation of type III secretion systems (T3SSs). This protein contains three repetitions of a helical motif flanked by disordered N- and C-terminal extensions. This entry represents the third helical domain of this protein.
Pfam PF05673: Protein of unknown function (DUF815) (family)
This family consists of several bacterial proteins of unknown function.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF17011: Domain of unknown function (DUF5093) (family)
This is a family of microsporidial sequences that may be distantly related to RRP7, [pfam:PF12923], ribosomal-RNA-processing protein 7.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF05811: Eukaryotic protein of unknown function (DUF842) (family)
This family consists of a number of conserved eukaryotic proteins of unknown function. The sequences carry three sets of CxxxC motifs, which might suggest a type of zinc-finger formation.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF08555: FAM32A (family)
FAM32A, also known as OTAG12, has been linked to ovarian tumour in humans and mice.
Pfam PF12219: Catalytic domain of bacteriophage endosialidase (repeat)
This domain family is found in bacteria and viruses, and is approximately 160 amino acids in length. There are two conserved sequence motifs: VSR and YGA. This domain is the C terminal domain of the bacteriophage protein endosialidase. The endosialidase protein forms homotrimeric molecules and this domain complexes into a tail-spike stalk. The stalk region folds in a triple beta-helix that is interrupted by a small triple beta-prism domain. The tail-spike is a multifunctional protein device used by the phage to fulfill the following functions: (i) to adsorb to the bacterial polySia capsule (ii) to de-polymerise the capsule to gain access to the outer bacterial membrane, and finally (iii) to mediate tight adhesion to the membrane, a prerequisite for the initiation of the infection cycle.
Pfam PF02487: CLN3 protein (family)
This is a family of proteins from the CLN3 gene. A mis-sense mutation of glutamic acid (E) to lysine (K) at position 295 in the human protein ([swissprot:Q13286]) has been implicated in Juvenile neuronal ceroid lipofuscinosis (Batten disease). Batten disease is characterised by the accumulation of autofluorescent material in the lysosomes of most cells. Members of this family are transmembrane proteins functional in pre-vacuolar compartments. The protein in Sch.pombe is found to be localised to the vacuolar membrane, and a lack of functional protein clearly affects the size and pH of the vacuole. Thus the protein is necessary for vacuolar homeostasis. It is important for localisation of late endosomal/lysosomal compartments, and it interacts with motor components driving both plus and minus end microtubular trafficking: tubulin, dynactin, dynein and kinesin-2.
Pfam PF06389: Filovirus membrane-associated protein VP24 (family)
This family consists of several membrane-associated protein VP24 sequences from a variety of Ebola and Marburg viruses. The VP24 protein of Ebola virus is believed to be a secondary matrix protein and minor component of virions. VP24 possesses structural features commonly associated with viral matrix proteins and that VP24 may have a role in virus assembly and budding.
Wikipedia: Ebola viral protein 24 (eVP24) is considered a multifunctional secondary matrix protein present in viral particles. The broad roles eVP24 performs involve the formation of fully functional and infectious viral particles, promotion of filamentous nucleocapsid formation, mediation of host responses to infection, and suppression of the host innate immune system. It has been noted that eVP24 function can overlap with that of two other viral proteins; eVP40 matrix protein which functions in virus budding, and eVP35 which is also associated with immune suppression.
Pfam PF24234: BICC1, first type I KH domain (domain)
This entry represents the first type I KH RNA-binding domain of BICC/BICC1. Bicaudal-C from Drosophila melanogaster (BICC) and its homologues from vertebrates BICC1 are RNA-binding proteins with translational repression function; they regulate gene expression and modulate cell proliferation and apoptosis. BICC1 is a negative regulator of Wnt signalling. These proteins are involved in the regulation of embryonic differentiation and play a role in the regulation of Dvl (Dishevelled) signalling, particularly in the correct cilia orientation and nodal flow generation.
Pfam PF20807: Viral structural protein 5 (family)
Viral structural protein 5 (VP5) is one of the three major capsid proteins found in Cytoplasmic polyhedrosis virus (CPV). This family is predominantly found in proteins from Reovirales.
Pfam PF19645: Family of unknown function (DUF6148) (family)
This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 80 amino acids in length.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF13185: GAF domain (domain)
The GAF domain is named after some of the proteins it is found in, including cGMP-specific phosphodiesterases, adenylyl cyclases and FhlA. It is also found in guanylyl cyclases and phytochromes. The structure of a GAF domain shows that the domain shares a similar fold with the PAS domain.  This domain can bind O2, CO and NO (Matilla et.al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).
Wikipedia: The GAF domain is a type of protein domain that is found in a wide range of proteins from all species. The GAF domain is named after some of the proteins it is found in: cGMP-specific phosphodiesterases, adenylyl cyclases and FhlA. The first structure of a GAF domain solved by Ho and colleagues showed that this domain shared a similar fold with the PAS domain. In mammals, GAF domains are found in five members of the cyclic nucleotide phosphodiesterase superfamily: PDE2, PDE5, and PDE6 which bind cGMP to the GAF domain, PDE10 which binds cAMP, and PDE11 which binds both cGMP and cAMP.
Pfam PF13457: GW (Gly-Tryp) dipeptide domain (domain)
This is a GW domain found in the C-terminal of InlB proteins which belong to the extended family of internalin proteins found in Listeria. These 80 residue GW domains are unique to InlB among the internalins but are present in other proteins of Gram-positive bacteria. GW domains (named after a GlyTryp dipeptide) are structurally and evolutionary related to SH3 domains. Despite of this, GW domains are unlikely to act as functional mimics of SH3 domains since their potential proline-binding sites are blocked or destroyed. They are highly basic and interact with poly-anions. The GW domains are responsible for the non-covalent attachment to the bacterial cell surface through binding to lipoteichoic acid. The GW domains alone do not stimulate uptake, but they synergize with the Met-binding internalin domain.
Pfam PF20778: SLS1 protein C-terminal beta barrel domain (domain)
This entry represents the C-terminal beta barrel domain found in the SLS1 protein.
Pfam PF02503: Polyphosphate kinase middle domain (domain)
Polyphosphate kinase (Ppk) catalyses the formation of polyphosphate from ATP, with chain lengths of up to a thousand or more orthophosphate molecules.
Wikipedia: In enzymology, a polyphosphate kinase, or polyphosphate polymerase, is an enzyme that catalyzes the formation of polyphosphate from ATP, with chain lengths of up to a thousand or more orthophosphate moieties.ATP + (phosphate)n  ADP + (phosphate)n+1
Pfam PF04350: Pilus assembly protein, PilO (family)
PilO proteins are involved in the assembly of pilin. However, the precise function of this family of proteins is not known.
Pfam PF14903: WG containing repeat (repeat)
This repeat contains an N-terminal WG repeat motif. The extent of the repeat is poorly defined. This repeat may form a beta solenoid structure (Bateman A pers. obs.).
Pfam PF03864: Phage major capsid protein E (family)
Major capsid protein E is involved with the stabilisation of the condensed form of the DNA molecule in phage heads.
Pfam PF22942: Domain of unknown function (DUF7025) (domain)
This entry represents an SH3 barrel like domain found in a large family of AAA proteins. The function of these proteins is uncertain.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF07991: Acetohydroxy acid isomeroreductase, NADPH-binding domain (family)
Acetohydroxy acid isomeroreductase catalyses the conversion of acetohydroxy acids into dihydroxy valerates. This reaction is the second in the synthetic pathway of the essential branched side chain amino acids valine and isoleucine. This N-terminal region of the enzyme carries the binding-site for NADPH. The active-site for enzymatic activity lies in the C-terminal part, IlvC, [pfam:PF01450].
Pfam PF21731: Target of Nesh-SH3 C-terminal domain (domain)
This domain is found at the C-terminus of the Target of Nesh-SH3 protein, also known as ABI3BP protein.
Pfam PF22499: Family of unknown function (DUF6990) (family)
This family of proteins is found in bacteria. Proteins in this family are typically between 185 and 199 amino acids in length. There are two semi-conserved sequence motifs: HLA and GFVPYI.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF22867: Protein YoaL (family)
This protein family includes Protein YoaL from Escherichia coli, the product of a small open reading frame (smORF), which may serve a regulatory role in the expression of its downstream gene.
Pfam PF04789: Protein of unknown function (DUF621) (family)
Family of uncharacterised proteins. Some (such as [swissprot:O01625]) are annotated as having possible G-protein-coupled receptor-like activity.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF13179: Family of unknown function (DUF4006) (family)
This is a family of short, approx 65 residue-long, bacterial proteins of unknown function.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF01392: Fz domain (domain)
Also known as the CRD (cysteine rich domain), the C6 box in MuSK receptor. This domain of unknown function has been independently identified by several groups.  The domain contains 10 conserved cysteines.
Pfam PF16596: Disordered region downstream of MFMR (disordered)
This is a conserved region of disorder, identified with the MobiDB database, found in plants immediately to the C-terminus of the MFMR domain.
Pfam PF18355: Domain of unknown function (DUF5607) (domain)
The structure of this domain in Pyrobaculum spherical virus has been determined (PDB:2X4J) .
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF19264: Repeat of unknown function (DUF5907) (repeat)
This entry represents a protein repeats whose length varies between 50 and 80 residues. It is found in a variety of iridoviruses. It may be  distantly related to minor tail protein found in phages.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF18185: Sir2- and TIR-associating SLOG family (family)
Family in the SLOG superfamily, associating with predicted Sir2- and TIR-like effector domains. Members of this family are predicted to functions as sensors of nucleotide or nucleotide-derived ligands, which are likely processed or modified by the associating effectors.
Pfam PF02410: Ribosomal silencing factor during starvation (family)
This family is expressed by almost all bacterial and eukaryotic genomes but not by archaea. Its function is to down-regulate protein synthesis under conditions of nutrient shortage, and it does this by binding to protein L14 of the large ribosomal subunit, thus acting as a ribosomal silencing factor (RsfS) by blocking the joining of the ribosomal subunits. This family is structurally homologous to nucleotidyltransferases.