SII-SWORD/CoKE huggingface dataset:
Pfam PF12401: FhaA, N-terminal domain (family)
This domain can be found at the N terminus of FHA domain-containing protein Fha from Mycobacterium tuberculosis. The FHA (Fork Head Associated) domain is a phosphopeptide- specific binding domain that enables the protein to specifically bind to sequences containing phosphothreonine. FhaA is one of the major substrates of Ser/Thr protein kinases (STPK) and plays a role in the regulation of cell growth and peptidoglycan synthesis by binding to MviN. It may inhibit the late stages of peptidoglycan synthesis.
Pfam PF00068: Phospholipase A2 (domain)
Phospholipase A2 releases fatty acids from the second carbon group of glycerol. Perhaps the best known members are secreted snake venoms, but also found in secreted pancreatic and membrane-associated forms. Structure is all-alpha, with two core disulfide-linked helices and a calcium-binding loop. This alignment represents the major family of PLA2s. A second minor family, defined by the honeybee venom PLA2 PDB:1POC and related sequences from Gila monsters (Heloderma), is not recognised. This minor family conserves the core helix pair but is substantially different elsewhere. The PROSITE pattern PA2_HIS, specific to the first core helix, recognises both families.
Wikipedia: The enzyme phospholipase A2 (EC 3.1.1.4, PLA2, systematic name  phosphatidylcholine 2-acylhydrolase) catalyses the cleavage of fatty acids in position 2 of phospholipids, hydrolyzing the bond between the second fatty acid "tail" and the glycerol molecule:phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate
Pfam PF13043: Domain of unknown function (DUF3903) (family)
This presumed domain is functionally uncharacterised. This domain family is found in bacteria, and is approximately 40 amino acids in length.
Pfam PF04134: DCC1-like thiol-disulfide oxidoreductase (family)
Members of this family have two highly conserved cysteine residues within the DxxCxxC motif at the N-terminal. This motif is conserved in the thiol-disulfide oxidoreductase family. This family includes At5g50100 (also known as DCC1) from Arabidopsis thaliana, a thioredoxin that modulates ROS homeostasis resulting in de novo shoot initiation and may be involved in the improvement of the capacity of plant regeneration. Uncharacterised proteins from bacteria are also included in this family.
Pfam PF07679: Immunoglobulin I-set domain (domain)
This entry represents I-set domains, which are found in several cell adhesion molecules, including vascular (VCAM), intercellular (ICAM), neural (NCAM) and mucosal addressin (MADCAM) cell adhesion molecules, as well as junction adhesion molecules (JAM). I-set domains are also present in several other diverse protein families, including several tyrosine-protein kinase receptors, the hemolymph protein hemolin, the muscle proteins titin, telokin, and twitchin, the neuronal adhesion molecule axonin-1 , the signalling molecule semaphorin 4D that is involved in axonal guidance, immune function and angiogenesis  and the Zwei Ig domain proteins zig involved in the postembriogenic neuronal soma and axon position maintenance .
The basic structure of immunoglobulin (Ig) molecules is a tetramer of two light chains and two heavy chains linked by disulphide bonds. There are two types of light chains: kappa and lambda, each composed of a constant domain (CL) and a variable domain (VL). There are five types of heavy chains: alpha, delta, epsilon, gamma and mu, all consisting of a variable domain (VH) and three (in alpha, delta and gamma) or four (in epsilon and mu) constant domains (CH1 to CH4). Ig molecules are highly modular proteins, in which the variable and constant domains have clear, conserved sequence patterns. The domains in Ig and Ig-like molecules are grouped into four types: V-set (variable; IPR013106), C1-set (constant-1; IPR003597), C2-set (constant-2; IPR008424) and I-set (intermediate; IPR013098) . Structural studies have shown that these domains share a common core Greek-key Î²-sandwich structure, with the types differing in the number of strands in the Î²-sheets as well as in their sequence patterns .

Immunoglobulin-like domains that are related in both sequence and structure can be found in several diverse protein families. Ig-like domains are involved in a variety of functions, including cell-cell recognition, cell-surface receptors, muscle structure and the immune system .
Wikipedia: I-set domains are found in several cell adhesion molecules, including vascular (VCAM), intercellular (ICAM), neural (NCAM) and mucosal addressin (MADCAM) cell adhesion molecules, as well as junction adhesion molecules (JAM). I-set domains are also present in several other diverse protein families, including several tyrosine-protein kinase receptors, the hemolymph protein hemolin, the muscle proteins titin, telokin, and twitchin, the neuronal adhesion molecule axonin-1, and the signalling molecule semaphorin 4D that is involved in axonal guidance, immune function and angiogenesis.
Pfam PF15298: AJAP1/PANP C-terminus (family)
This family includes the C-terminus of adherens junction-associated protein 1 (AJAP1) and of PILR-associating neural protein (PANP). AJAP1 inhibits cell adhesion and migration. PANP is a ligand for the immune inhibitory receptor paired immunoglobulin-like type 2 receptor alpha.
Pfam PF13089: Polyphosphate kinase N-terminal domain (domain)
Polyphosphate kinase (Ppk) catalyses the formation of polyphosphate from ATP, with chain lengths of up to a thousand or more orthophosphate molecules.
Pfam PF16701: Adenylate cyclase regulatory domain (domain)
This domain regulates the activity of Actinobacterial adenylate cyclase in a pH-dependent manner, allowing activation at acidic pH.
Pfam PF11606: Family 31 carbohydrate binding protein (family)
This family of proteins represents the family 31 carbohydrate-binding module of beta-1,2-xylanase. This protein is from Alcaligenes sp. strain XY-234. The AlcCBM31 module makes a beta-sandwich structure with an immunoglobulin fold and contains two intra-molecular disulfide bonds. AlcCBM31 shows affinity with only beta-1,3-xylan.
Pfam PF08929: PoNe immunity proteins (PoNi), C-terminal (domain)
This entry represents  the C-terminal domain of the PoNe immunity proteins (PoNi), which antagonize the DNAse toxin PoNe (Polymorphic Nuclease effector). PoNi proteins may directly interact with PoNe.
Pfam PF04704: Zfx / Zfy transcription activation region (family)
Zfx and Zfy are transcription factors implicated in mammalian sex  determination. This region is found N terminal to multiple copies of a C2H2 Zinc finger  ([pfam:PF00096]).  This region has been shown to activate transcription when fused to a GAL4 DNA binding domain.
Pfam PF14905: Outer membrane protein beta-barrel family (family)
This family includes proteins annotated as TonB dependent receptors. But it is also likely to contain other membrane beta barrel proteins of other functions.
Pfam PF13444: Acetyltransferase (GNAT) domain (domain)
This family contains proteins with N-acetyltransferase functions.
Wikipedia: An acetyltransferase is any of a class of transferase enzymes that transfers an acetyl group in a reaction called acetylation. In biological organisms, post-translational modification of a protein via acetylation can profoundly transform its functionality by altering various properties like hydrophobicity, solubility, and surface attributes. These alterations have the potential to influence the protein's conformation and its interactions with substrates, cofactors, and other macromolecules.
Pfam PF12374: Double-sex mab3 related transcription factor 1 (family)
This domain family is found in eukaryotes, and is typically between 61 and 73 amino acids in length. The family is found in association with [pfam:PF00751]. This family is a transcription factor involved in sex determination. The proteins in this family contain a zinc finger-like DNA-binding motif, DM domain.
Wikipedia: In molecular biology the DM domain is a protein domain first discovered in the doublesex proteins of Drosophila melanogaster and is also seen in C. elegans and mammalian proteins. In D. melanogaster the doublesex gene controls somatic sexual differentiation by producing alternatively spliced mRNAs encoding related sex-specific polypeptides. These proteins are believed to function as transcription factors on downstream sex-determination genes, especially on neuroblast differentiation and yolk protein genes transcription.
Pfam PF09719: Putative redox-active protein (C_GCAxxG_C_C) (family)
This entry represents a putative redox-active protein of about 140 residues, with four perfectly conserved Cys residues. It includes a CGAXXG motif. Most members are found within one or two loci of transporter or oxidoreductase genes. A member from Geobacter sulfurreducens, located in a molybdenum transporter operon, has a TAT (twin-arginine translocation) signal sequence for Sec-independent transport across the plasma membrane, a hallmark of bound prosthetic groups such as FeS clusters.
Pfam PF08893: Domain of unknown function (DUF1839) (family)
This family of proteins are functionally uncharacterised.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF08605: Fungal Rad9-like Rad53-binding (family)
In Saccharomyces cerevisiae the Rad9 a key adaptor protein in DNA damage checkpoint pathways.  DNA damage induces Rad9 phosphorylation, and Rad53 specifically associates with this region of Rad9, when phosphorylated, via Rad53 [pfam:PF00498] domains. This region is structurally composed of a pair of TUDOR domains.
Pfam PF11396: Putative beta-lactamase-inhibitor-like, PepSY-like (domain)
This family of bacterial proteins is probably periplasmic. Members are found predominantly in microbes of the human gut and oral cavity. Structurally, one member of this family is found to show similarity to the beta-lactamase-inhibitor PepSY proteins, so the overall function may be inhibitory. There are tandem repeats of the domain on many family members.
Pfam PF20978: Glutamyl-tRNA amidotransferase complex subunit Gta3 (family)
This family represents glutamyl-tRNA amidotransferase complex subunit Gta3 from S. pombe, an orthologue of yeast GTF1 and human Glutamyl-tRNA(Gln) amidotransferase subunit C (GATC).
Pfam PF01024: Colicin pore forming domain (domain)
Colicins are plasmid-encoded polypeptide toxins produced by and active against Escherichia coli and closely related bacteria. Colicins are released into the environment to reduce competition from other bacterial strains. Colicins bind to outer membrane receptors, using them to translocate to the cytoplasm or cytoplasmic membrane, where they exert their cytotoxic effect, including depolarisation of the cytoplasmic membrane, DNase activity, RNase activity, or inhibition of murein synthesis.

Channel-forming colicins (colicins A, B, E1, Ia, Ib, and N) are transmembrane proteins that depolarize the cytoplasmic membrane, leading to dissipation of cellular energy . These colicins contain at least three domains: an N-terminal translocation domain responsible for movement across the outer membrane and periplasmic space; a central domain responsible for receptor recognition; and a C-terminal cytotoxic domain responsible for channel formation in the cytoplasmic membrane .

This entry represents the C-terminal cytotoxic domain, which has a globin-like fold with additional helices at either end.
Pfam PF20011: JAB N-terminal domain (domain)
Domain observed N-terminal to JAB deubiquitinase in the Ub system component of the FtsH ternary systems, a class of NTP-dependent biological conflict systems.
Pfam PF18111: Retinitis pigmentosa G-protein regulator interacting C-terminal (domain)
This is the C-terminal domain of retinitis pigmentosa G-protein regulator (RPGR) interacting protein-1 present in Homo sapiens. A mutation in RPGR interacting protein-1 can be observed in the eye disease Leber congenital amaurosis. The domain is commonly known as the RPGR-interacting domain (RID) and is thought to have a C2-like fold.
Pfam PF06351: Allene oxide cyclase (family)
This family consists of several plant specific allene oxide cyclase proteins ([ec:5.3.99.6]). The allene oxide cyclase (AOC)-catalysed step in jasmonate (JA) biosynthesis is important in the wound response of tomato.
Pfam PF05537: Borrelia burgdorferi protein of unknown function (DUF759) (family)
This family consists of several uncharacterised proteins from the Lyme disease spirochete Borrelia burgdorferi.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF09023: Staphostatin B (domain)
Staphostatin B inhibits the cysteine protease Staphopain B, produced by Staphylococcus aureus, by blocking the active site of the enzyme. The domain adopts an eight-stranded mixed beta-barrel structure, with a deviation from the up-down topology of canonical beta-barrels in the amino-terminal part of the molecule.
Pfam PF13382: Adenine deaminase C-terminal domain (family)
This family represents a C-terminal region of the adenine deaminase enzyme.
Pfam PF13831: PHD-finger (family)
PHD folds into an interleaved type of Zn-finger chelating 2 Zn ions in a similar manner to that of the RING and FYVE domains.  Several PHD fingers have been identified as binding modules of methylated histone H3.
Wikipedia: The PHD finger was discovered in 1993 as a Cys4-His-Cys3 motif in the plant homeodomain proteins HAT3.1 in Arabidopsis and maize ZmHox1a. 
The PHD zinc finger motif resembles the metal binding RING domain (Cys3-His-Cys4) and FYVE domain. It occurs as a single finger, but often in clusters of two or three, and it also occurs together with other domains, such as the chromodomain and the bromodomain.
Pfam PF07920: Protein of unknown function (DUF1684) (family)
The sequences featured in this family are found in hypothetical archaeal and bacterial proteins  of unknown function. The region in question is approximately 200 amino acids long.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF22086: Family of unknown function (DUF6940) (family)
This is a family of uncharacterised proteins found in bacteria and eukaryotes. These proteins are probably distantly related to HIT-containing uridylyltransferases and are likely to adopt the same structure.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF19893: Family of unknown function (DUF6366) (family)
This family of proteins is functionally uncharacterised. Proteins in this family are found in bacteria and they are approximately 70 amino acids in length. It contains the RE/K and GW conserved motifs.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF16508: Second BRCT domain on Nijmegen syndrome breakage protein (domain)
This entry represents the second BRCT domain of Nibrin (or Nbs1), a component of the MRN (Mre11-Rad50-Nbs1) complex that is involved in the DNA damage response. This domain (BRCT2) is identified through nuclear magnetic resonance (NMR) spectroscopy structure determination. It is downstream from BRCT1 domain and has no significant amino acid sequence homology to other BRCT domains. However, it has the Î±/Î² topology characteristic of BRCT domains in other proteins, but differs markedly in having a disordered long loop inserted between Î± Î² strand and an Î± helix. BRCT2 is essential for an MDC1-dependent relocalisation of Nbs1 to DNA damage sites .
Pfam PF00321: Plant thionin (domain)
Thionins are small, basic plant proteins, 45 to 50 amino acids in length, which include three or four conserved disulphide linkages. The proteins are toxic to animal cells, presumably attacking the cell membrane and rendering it permeable: this results in the inhibition of sugar uptake and allows potassium and phosphate ions, proteins, and nucleotides to leak from cells . Thionins are mainly found in seeds where they may act as a defence against consumption by animals. A barley (Hordeum vulgare) leaf thionin that is highly toxic to plant pathogens and is involved in the mechanism of plant defence against microbial infections has also been identified . The hydrophobic protein crambin from the Abyssinian kale (Crambe abyssinica) is also a member of the thionin family .
Wikipedia: Thionins are a family of small proteins found solely in higher plants. Typically, a thionin consists of 45–48 amino acid residues. 6–8 of these are cysteine forming 3–4 disulfide bonds. They include phoratoxins and viscotoxins.
Pfam PF04363: Protein of unknown function (DUF496) (family)
Members of this family are uncharacterised proteins.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF11044: Plectrovirus spv1-c74 ORF 12 transmembrane protein (family)
This is a family of proteins expressed by Plectroviruses. The plectroviruses are single-stranded DNA viruses belonging to the Inoviridae. Except that it is a putative transmembrane protein the function is not known.
Pfam PF03408: Foamy virus envelope protein (family)
Expression of the envelope (Env) glycoprotein is essential for viral  particle egress.  This feature is unique to the Spumavirinae, a  subclass of the Retroviridae.
Pfam PF15536: Bacterial toxin 3 (family)
A predicted RNase toxin found in bacterial polymorphic toxin systems.  The toxin possesses an all-beta fold and conserved aspartate, arginine, histidine and cysteine residues that is usually exported by the Photorhabdus virulence cassette (PVC)-type export system.
Pfam PF05139: Erythromycin esterase (family)
This family includes erythromycin esterase enzymes that confer resistance to the erythromycin antibiotic.
Pfam PF21581: Stromalin conservative domain (repeat)
This entry represents a conserved domain found in stromal antigen or stromalin proteins, also known as cohesin subunit SA-1/2/3 (STAG1-3 or SCC3 homologue 1-3) that were originally identified from a murine bone marrow stromal cell line and are represented in several organisms from yeast to humans. The homologues from yeast are cohesin subunit SCC3 and meiotic recombination protein Rec11. STAG1-3 and SCC3 are components of the cohesin complex, which is required for the cohesion of sister chromatids after DNA replication. This domain consists of HEAT-like repeated helices. Mutations in STAG3 have been associated with male infertility.
Pfam PF09789: Coiled-coil domain-containing protein 149-A (coiled_coil)
Members of this family have been annotated as being coiled-coil domain-containing protein 149, however they currently have no known function.
Pfam PF20308: Tetratricopeptide Repeats-Sensor (repeat)
This entry represents a sensor domain consisting of 7 TPR repeats forming a tightly-wound solenoid structure harbouring a deep central pocket. The TPR-S binding pocket is lined with several conserved aromatic and polar residues predicted to bind a NAD+-derived nucleotide in prokaryotic NAD+-derived nucleotide-activated effector conflict systems. It has been acquired at the base of the choanoflagellate-animal lineage as a core component of the ASK signalosome.
Pfam PF19987: Family of unknown function (DUF6423) (family)
This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0001503) is described by MIBiG as an example of the following biosynthetic class, polyketide, in particular the  amycolamycin A biosynthetic gene cluster from Amycolatopsis sp..
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF16766: Binding region of GANP to ENY2 (family)
CID is a domain on higher eukaryotic germinal-cent associated nuclear protein, or GANP, that binds to the transcription and mRNA export factor ENY2. The complex of these two proteins forms part of the TREX-2 complex that links transcription with nuclear messenger RNA export.
Pfam PF21668: DNA-directed RNA polymerase subunit beta', hybrid domain (domain)
This is a hybrid domain found in DNA-directed RNA polymerase subunit beta' (RPOC) found in Deinococcus.
Pfam PF17750: Reovirus sigma C capsid protein triple beta spiral (family)
This short region forms a triple beta spiral structural motif.
Pfam PF12651: Ribbon-helix-helix domain (domain)
This short bacterial protein contains a ribbon-helix-helix domain that is likely to be DNA-binding.
Pfam PF12059: Protein of unknown function (DUF3540) (family)
This family of proteins is functionally uncharacterised. This protein is found in bacteria. Proteins in this family are typically between 212 to 238 amino acids in length. This protein has a conserved SCL sequence motif.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF15044: Mitochondrial function, CLU-N-term (family)
CLU_N is the N-terminal domain of the Clueless protein, also known as TIF31-like in other organisms.  The function of this domain is not known. It family is found in association with [pfam:PF13236].