SII-SWORD/CoKE huggingface dataset:
Pfam PF07913: Protein of unknown function (DUF1678) (family)
This family is composed of uncharacterized proteins expressed by Methanopyrus kandleri, a hyperthermophilic archaebacterium.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF10755: Protein of unknown function (DUF2585) (family)
This family is conserved in Proteobacteria. The function is not known.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF17870: Insulin receptor trans-membrane segment (domain)
This entry represents the trans-membrane domain (TMD) found in insulin receptor proteins. The TMD of the insulin receptor is within the beta-subunit and contains 23 amino acids. Mutations in the TMD were shown to have effects on receptor biosynthetic processing and kinase activation. Substitution of the entire TMD of the insulin receptor (IR) resulted in constitutive kinase activation in vitro, while replacing the TMD with that of glycophorin A inhibited insulin action. Structural studies show that TMD contains a helix and a kink when it is purified in dodecylphosphocholine (DPC) micelles. The residues 942-948 preceding the TMD have a propensity to be a short helix and may interact with membrane.
Pfam PF06796: Periplasmic nitrate reductase protein NapE (family)
This family consists of several bacterial periplasmic nitrate reductase NapE proteins. Seven genes, napKEFDABC, encoding the periplasmic nitrate reductase system were cloned from the denitrifying phototrophic bacterium Rhodobacter sphaeroides f. sp. denitrificans IL106. NapE is thought to be a transmembrane protein.
Wikipedia: Nitrate reductases are molybdoenzymes that reduce nitrate to nitrite. This reaction is critical for the production of protein in most crop plants, as nitrate is the predominant source of nitrogen in fertilized soils.
Pfam PF07734: F-box associated (repeat)
Most of these proteins contain [pfam:PF00646] at the N terminus, suggesting that they are effectors linked with ubiquitination.
Pfam PF02302: PTS system, Lactose/Cellobiose specific IIB subunit (domain)
The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. The lactose/cellobiose-specific family are one of four structurally and functionally distinct group IIB PTS system cytoplasmic enzymes. The fold of IIB cellobiose shows similar structure to mammalian tyrosine phosphatases.  This family also contains the fructose specific IIB subunit.
Pfam PF06891: P2 phage tail completion protein R (GpR) (domain)
This family consists of P2 phage tail completion protein R (GpR) like sequences. GpR is thought to be a tail completion protein which is essential for stable head joining.
Pfam PF21037: Coiled-coil-domain-containing protein 138, coiled-coil (coiled_coil)
This is the coiled-coil region of coiled-coil domain-containing protein 138 (CCDC138) whose function is not yet clear. However, it has been localised to basal bodies, suggesting to play a role in centrosomal and ciliary biology.
Pfam PF18121: TFA2 Winged helix domain 2 (domain)
This is the second winged helix domain can be found in TFA2 proteins present in Saccharomyces cerevisiae. In form 2, the domain interacts directly with Rad3, a DNA helicase.
Pfam PF23226: PGAP2IP, C-terminal nuclease-like domain (domain)
This domain is found C-terminal in the human PGAP2-interacting protein (PGAP2IP) and its homologues in yeast CWH43. PGAP2IP is composed of three domains. Two of these domains are predicted to adopt very similar structure consisting of six transmembrane helices suggesting a possible duplication event in these proteins. Its yeast homologue CWH43 is involved in the remodeling of the lipid moiety of GPI anchors to ceramides. The domain represented by this entry has a significant sequence similarity to DNase I-like domains and it is predicted to adopt similar structure.
Pfam PF05316: Mitochondrial ribosomal protein (VAR1) (family)
This family consists of the yeast mitochondrial ribosomal proteins VAR1. Mitochondria possess their own ribosomes responsible for the synthesis of a small number of proteins encoded by the mitochondrial genome. In yeast the two ribosomal RNAs and a single ribosomal protein, VAR1, are products of mitochondrial genes, and the remaining approximately 80 ribosomal  proteins are encoded in the nucleus. VAR1 along with 15S rRNA are  necessary for the formation of mature 37S subunits.
Wikipedia: In molecular biology, VAR1 protein domain, otherwise known as variant protein 1, is a ribosomal protein that forms part of the small ribosomal subunit in yeast mitochondria. Mitochondria possess their own ribosomes responsible for the synthesis of a small number of proteins encoded by the mitochondrial genome. VAR1 is the only protein in the yeast mitochondrial ribosome to be encoded in the mitochondria - the remaining approximately 80 ribosomal proteins are encoded in the nucleus. VAR1 along with 15S rRNA are necessary for the formation of mature 37S subunits.
Pfam PF17805: AsnC-like ligand binding domain (domain)
This entry contains an AsnC-like ligand binding domain.
Pfam PF15777: Tryptophan RNA-binding attenuator protein inhibitory protein (domain)
Tryptophan RNA-binding attenuator protein (TRAP) inhibitory protein, also known as anti-TRAP (AT), recognises the tryptophan-activated RNA-binding domain of TRAP, a protein that regulates expression of genes involved in tryptophan metabolism in response to the accumulation of l-tryptophan . Anti-TRAP relieves TRAP-mediated repression of the trp operon expression by binding directly to Trp-bound activated TRAP and excluding RNA binding .
Wikipedia: The Tryptophan operon leader is an RNA element found at the 5′ of some bacterial tryptophan operons. The leader sequence can form two different structures known as the terminator and the anti-terminator, based on the Tryptophan amounts in the cell. The leader also codes for very short peptide sequence that is rich in tryptophan. The terminator structure is recognised as a termination signal for RNA polymerase and the operon is not transcribed. This structure forms when the cell has an excess of tryptophan and ribosome movement over the leader transcript is not impeded. When there is a deficiency of the charged tryptophanyl tRNA the ribosome translating the leader peptide stalls and the antiterminator structure can form. This allows RNA polymerase to transcribe the operon.
Pfam PF02011: Glycosyl hydrolase family 48 (repeat)
Members of this family are endoglucanase [ec:3.2.1.4] and exoglucanase [ec:3.2.1.91] enzymes that cleave cellulose or related substrate.
Wikipedia: In molecular biology, glycoside hydrolase family 48 is a family of glycoside hydrolases.
Pfam PF13161: Protein of unknown function (DUF3996) (family)
This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 172 and 203 amino acids in length.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF23465: Domain of unknown function (DUF7131) (domain)
This entry is a domain of unknown function found in some PA-PLA1 family members, which consists of mitochondrial proteins that are probable phospholipases with a specific function to hydrolyze phosphatidic acid. Members of this family are involved in the metabolism of phospholipids, which are critical components of cell membranes. By hydrolyzing phosphatidic acid, these enzymes may play a role in the regulation of mitochondrial membrane composition and dynamics, as well as in signaling pathways related to lipid metabolism.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF06838: Methionine gamma-lyase (domain)
This is a putative pyridoxal 5'-phosphate-dependent methionine gamma-lyase enzyme involved in methionine catabolism.
Pfam PF07048: Protein of unknown function (DUF1331) (family)
This family consists of several Circovirus proteins of around 35 residues in length. Members of this family are described as ORF-10 proteins and their function is unknown.
Pfam PF20366: Family of unknown function (DUF6661) (family)
This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 200 amino acids in length.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF04540: Herpesvirus UL51 protein (family)
UL51 protein is a virion protein. In pseudorabies virus, UL51 ([swissprot:Q85227]) was identified as a component of the capsid. In herpes simplex virus type 1 there is evidence for post-translational modification of UL51.
Pfam PF23021: PGAP2IP, second transmembrane domain (domain)
This domain is found in the human PGAP2-interacting protein (PGAP2IP) and its homologues in yeast CWH43. PGAP2IP is composed of three domains. Two of these domains are predicted to adopt very similar structure consisting of six transmembrane helices, which suggests a possible duplication event in these proteins. Its yeast homologue CWH43 is involved in the remodeling of the lipid moiety of GPI anchors to ceramides.
Pfam PF19117: Mitochondrial import 2 (family)
This entry, together with PFAM:PF08219 form the Mim1/Mim2 complex, which is specific to fungi. This complex is responsible for the assembly and/or insertion of a subset of mitochondrial outer membrane proteins, including subunits of the main mitochondrial outer membrane translocase.
Pfam PF21841: Family of unknown function (DUF6900) (family)
This entry represents a small domain found in a range of bacterial and phage proteins. In a few proteins it is associated with [pfam:PF11994]. This region is composed of two alpha helices.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF19074: Family of unknown function (DUF5770) (family)
This is a family of uncharacterised proteins of unknown function found in Iridoviridae.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF10710: Protein of unknown function (DUF2512) (family)
Proteins in this family are predicted to be integral membrane proteins, and many of them are annotated as being YndM protein. They are all found in Firmicutes. The true function is not known.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF14438: Ataxin 2 SM domain (domain)
This SM domain is found in Ataxin-2.
Pfam PF00255: Glutathione peroxidase (family)
Glutathione peroxidase (GSHPx) (1.11.1.9) is an enzyme that catalyses the reduction of hydroperoxides by glutathione . Its main function is to protect against the damaging effect of endogenously formed hydroperoxides. In higher vertebrates, several forms of GSHPx are known, including a ubiquitous cytosolic form (GSHPx-1), a gastrointestinal cytosolic form (GSHPx-GI), a plasma secreted form (GSHPx-P), and an epididymal secretory form (GSHPx-EP). In mammals there are eight GPx, divided in two clusters, the classical GPx (GPx1, GPx2, GPx3, GPx5 and GPx6) and phospholipid hydroperoxide GPx (GPx4, GPx7 and GPx8). The classical GPx is multimeric (commonly tetrameric) and soluble, while the phospholipid hydroperoxide (PHGPx) is monomeric and often membrane-associated . In addition to these characterised forms, the sequence of a protein of unknown function  has been shown to be evolutionary related to those of GSHPx's.

In filarial nematode parasites, the major soluble cuticular protein (gp29) is a secreted GSHPx, which may provide a mechanism of resistance to the immune reaction of the mammalian host by neutralising the products of the oxidative burst of leukocytes . The structure of bovine seleno-glutathione peroxidase has been determined . The protein belongs to the Î±-Î² class, with a three layer(aba) sandwich architecture. The catalytic site of GSHPx contains a conserved residue which is either a cysteine or, in many eukaryotic GSHPx, a selenocysteine .
Wikipedia: Glutathione peroxidase (GPx) is the general name of an enzyme family with peroxidase activity whose main biological role is to protect the organism from oxidative damage. The biochemical function of glutathione peroxidase is to reduce lipid hydroperoxides to their corresponding alcohols and to reduce free hydrogen peroxide to water.
Pfam PF13801: Heavy-metal resistance (family)
This is a metal-binding protein which is involved in resistance to heavy-metal ions. The protein forms a four-helix hooked hairpin, consisting of two long alpha helices each flanked by a shorter alpha helix. It binds a metal ion in a type-2 like centre. It contains two copies of an LTXXQ motif.
Pfam PF24836: NqrA second alpha/beta domain (domain)
This domain is found in several bacterial Na(+)-translocating NADH-quinone reductase subunit A (NqrA) proteins. The Na(+)-translocating NADH: ubiquinone oxidoreductase (Na(+)-NQR) generates an electrochemical Na(+) potential driven by aerobic respiration. This domain has an alpha/beta structure and binds an FMN cofactor.
Pfam PF09734: RNA polymerase III transcription factor (TF)IIIC subunit HTH domain (family)
TFIIIC1 is a multisubunit DNA binding factor that serves as a dynamic platform for assembly of pre-initiation complexes on class III genes. This entry represents the tau 95 subunit which holds a key position in TFIIIC, exerting both upstream and downstream influence on the TFIIIC-DNA complex by rendering the complex more stable. Once bound to tDNA-intragenic promoter elements, TFIIIC directs the assembly of TFIIIB on the DNA, which in turn recruits the RNA polymerase III (pol III) and activates multiple rounds of transcription.
Pfam PF24549: Domain of unknown function (DUF7602) (domain)
This domain is found in uncharacterised sequences from Plasmodium falciparum and related sequences from Apicomplexa. The function is unknown.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF01087: Galactose-1-phosphate uridyl transferase, N-terminal domain (domain)
SCOP reports fold duplication with C-terminal domain.  Both involved in Zn and Fe binding.
Wikipedia: Galactose-1-phosphate uridyltransferase is an enzyme responsible for converting ingested galactose to glucose.
Pfam PF11064: Protein of unknown function (DUF2865) (family)
This bacterial family of proteins has no known function.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF11967: Recombination protein O N terminal (domain)
Recombination protein O (RecO) is involved in DNA repair and [pfam:PF00470] pathway recombination.  This domain forms a beta barrel structure.
Pfam PF14333: Domain of unknown function (DUF4389) (family)
This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and archaea. Proteins in this family are typically between 104 and 223 amino acids in length. There is a single completely conserved residue R that may be functionally important.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF16485: Protealysin propeptide (domain)
This propeptide is cleaved during maturation of protealysin. Before cleavage it interacts with the catalytic domain, blocking the active site.
Pfam PF07438: Protein of unknown function (DUF1514) (family)
This family consists of several Staphylococcus aureus and related bacteriophage proteins of around 65 residues in length. The function of this family is unknown. Structural modelling suggests this domain may bind nucleic acids.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF09979: Uncharacterized protein conserved in bacteria (DUF2213) (family)
Members of this family of bacterial proteins comprise various hypothetical and phage-related proteins. The exact function of these proteins has not, as yet, been determined.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF19805: Family of unknown function (DUF6288) (family)
This family of bacterial proteins is functionally uncharacterised. Proteins in this family are approximately 800 amino acids in length and they presumably contain PDZ domains.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF21056: Zinc finger SWIM domain-containing protein 1/3, RNaseH-like domain (domain)
This is a domain found at the N-terminal of Zinc finger SWIM domain-containing protein 1 and in the central region of ZSWIM3, whose function is not yet clear. ZSWIM1 may play a role in the development or function of T helper cells. This domain may adopt an alpha-beta conformation according to AlphaFold structure predictions, closely related to RNaseH-like domains.
Pfam PF17220: Protein of unknown function (DUF5137) (family)
This is a family of uncharacterised yeast proteins.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF03818: Malonate/sodium symporter MadM subunit (family)
This entry represent the N-terminal domain of the malonate/sodium symporter MadM subunit
The MSS family includes the monobasic malonate:Na+ symporter of Malonomonas rubra. It consists of two integral membrane proteins, MadL and MadM .The transporter is believed to catalyze the electroneutral reversible uptake of H+-malonate with one Na+, and both subunits have been shown to be essential for activity.
Pfam PF09176: Methylene-tetrahydromethanopterin dehydrogenase, N-terminal (domain)
Members of this family adopt a alpha-beta structure, with a core comprising three alpha/beta/alpha layers, in which each sheet contains four strands. They are predominantly found in prokaryotic methylene-tetrahydromethanopterin dehydrogenase, which catalyses the dehydrogenation of methylene-tetrahydromethanopterin and the reversible dehydrogenation of methylene-H(4)F.
Pfam PF11131: Rap-phr extracellular signalling (family)
PhrC and PhrF stimulate ComA-dependent gene expression to different levels and are both required for full expression of genes activated by ComA, which activates the expression of genes involved in competence development and the production of several secreted products.
Pfam PF07057: DNA helicase TraI, C-terminal (domain)
This entry represents the C-terminal domain of the bacterial DNA helicase TraI ([ec:3.6.1.-]). TraI is a bifunctional protein that catalyses the unwinding of duplex DNA as well as acts as a sequence-specific DNA trans-esterase, providing the site- and strand-specific nick required to initiate DNA transfer. This domain is essential for conjugative DNA transfer.