SII-SWORD/CoKE huggingface dataset:
Pfam PF24378: Family of unknown function (DUF7534) (family)
This family includes a group of proteins from archaea. Members are predicted to adopt an alpha-helical structure.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF08531: Alpha-L-rhamnosidase N-terminal domain (domain)
This family consists of bacterial rhamnosidase A and B enzymes. This domain is probably involved in substrate recognition.
Pfam PF07196: Flagellin hook IN motif (conserved_site)
The function of this region is not clear, but it is found in many flagellar hook proteins, including FliD homologues (). It is normally repeated, but is also apparently seen as a singleton. A conserved IN is seen at the centre of the motif. The diversity of these motifs makes it likely that some members of the family are not identified.
Pfam PF07676: WD40-like Beta Propeller Repeat (repeat)
This family appears to be related to the [pfam:PF00400] repeat. This  repeat corresponds to the RIVW repeat identified in cell surface proteins [Adindla et al. Comparative and Functional Genomics 2004; 5:2-16].
Pfam PF07012: Curlin associated repeat (repeat)
This family consists of several bacterial repeats of around 30 residues in length. These repeats are often found in multiple copies in the curlin proteins CsgA and CsgB. Curli fibres are thin aggregative surface fibres, connected with adhesion, which bind laminin, fibronectin, plasminogen, human contact phase proteins, and major histocompatibility complex (MHC) class I molecules. Curli fibres are coded for by the csg gene cluster, which is comprised of two divergently transcribed operons. One operon encodes the csgB, csgA, and csgC genes, while the other encodes csgD, csgE, csgF, and csgG. The assembly of the fibres is unique and involves extracellular self-assembly of the curlin subunit (CsgA), dependent on a specific nucleator protein (CsgB). CsgD is a transcriptional activator essential for expression of the two curli fibre operons, and CsgG is an outer membrane lipoprotein involved in extracellular stabilisation of CsgA and CsgB.
Pfam PF09334: tRNA synthetases class I (M) (family)
This family includes methionyl tRNA synthetases.
Pfam PF15487: FAM220 family (family)
This protein family is a domain of unknown function which is found in eukaryotes. Proteins in this family are typically between 217 and 277 amino acids in length. There are two completely conserved residues (S and L) that may be functionally important.
Pfam PF02272: DHHA1 domain (domain)
This domain is often found adjacent to the DHH domain [pfam:PF01368] and is called DHHA1 for DHH associated domain. This domain is diagnostic of DHH subfamily 1 members. This domains is also found in alanyl tRNA synthetase e.g. [swissprot:P00957], suggesting that this domain may have an RNA binding function. The domain is about 60 residues long and contains a conserved GG motif.
Pfam PF14015: Protein of unknown function (DUF4231) (family)
This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria, archaea, eukaryotes and viruses. Proteins in this family are typically between 148 and 288 amino acids in length.
Pfam PF23213: Domain of unknown function (DUF7065) (domain)
This is a domain of unknown function found in fungi and bacteria, which, according to structure predictions it adopts a lipocalin-like fold. This domain is found as a pair of two flattened, orthogonally packed, beta-barrels. This entry represents the N-terminal barrel of the pair. In some members, the lipocalin-like domains (also referred to as AttH-like) are associated with a protein kinase-like domain at the N-terminal ([pfam:PF01636]).
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF08622: Svf1-like N-terminal lipocalin domain (domain)
Family of proteins that are involved in survival during oxidative stress. This entry corresponds to the N-terminal lipocalin domain of a pair.
Pfam PF06865: Pyrimidine/purine nucleoside phosphorylase (domain)
This family consist of YaiE and related proteins. YaiE from E. coli catalyses phosphorolysis of diverse nucleosides, yielding D-ribose 1-phosphate and free bases.
Pfam PF07166: Protein of unknown function (DUF1398) (family)
This family consists of several hypothetical Enterobacterial proteins of around 130 residues in length. Members of this family seem to be found exclusively in Escherichia coli and Salmonella species. The function of this family is unknown.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF24132: Family of unknown function (DUF7399) (family)
This entry represents a family of phage proteins. The proteins appear to contain two domains. The N-terminal domain contains a small beta sheet wrapped around an alpha helix. The second domain is composed of a pair of alpha helices.  The proteins are found in several viruses within the proposed new Crassvirales order of bacteriophages.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF03426: Carbohydrate binding domain (family 15) (domain)
This entry represents CBM15 which binds to xylan and xylooligosaccharides .
A carbohydrate-binding module (CBM) is defined as a contiguous amino acid sequence within a carbohydrate-active enzyme with a discreet fold having carbohydrate-binding activity. A few exceptions are CBMs in cellulosomal scaffolding proteins and rare instances of independent putative CBMs. The requirement of CBMs existing as modules within larger enzymes sets this class of carbohydrate-binding protein apart from other non-catalytic sugar binding proteins such as lectins and sugar transport proteins.

CBMs were previously classified as cellulose-binding domains (CBDs) based on the initial discovery of several modules that bound cellulose . However, additional modules in carbohydrate-active enzymes are continually being found that bind carbohydrates other than cellulose yet otherwise meet the CBM criteria, hence the need to reclassify these polypeptides using more inclusive terminology.

Previous classification of cellulose-binding domains were based on amino acid similarity. Groupings of CBDs were called "Types" and numbered with roman numerals (e.g. Type I or Type II CBDs). In keeping with the glycoside hydrolase classification, these groupings are now called families and numbered with Arabic numerals. Families 1 to 13 are the same as Types I to XIII. For a detailed review on the structure and binding modes of CBMs see .
Wikipedia: In molecular biology, a carbohydrate-binding module (CBM) is a protein domain found in carbohydrate-active enzymes. The majority of these domains have carbohydrate-binding activity. Some of these domains are found on cellulosomal scaffoldin proteins. CBMs were previously known as cellulose-binding domains. CBMs are classified into numerous families, based on amino acid sequence similarity. There are currently 64 families of CBM in the CAZy database.
Pfam PF12282: Histidine kinase PdtaS, GAF domain (domain)
This entry represents the GAF domain of the sensor region in the cytosolic histidine kinase (HK), PdtaS, from Mycobacterium tuberculosis. The N-terminal region of this protein is comprised of closely linked GAF and PAS domains, both are ubiquitous and form dimeric interfaces. GAF domains are known to bind heme (as can PAS domains), to be involved in redox responses and even to function as catalytic domains.
Pfam PF25036: Vacuolar-sorting associated protein 13, adaptor binding domain (domain)
This entry represents the VPS13 adaptor binding (VAB) domain, previously known as SHR-BD, found in vacuolar protein sorting-associated protein 13 (VPS13). Proteins containing this domain are involved in vesicle fusion, autophagy, and actin regulation and, through membrane-specific adaptor proteins such as Ypt35, Spo71 and the mitochondrial membrane protein Mcp1, VPS13 proteins are recruited to different membranes. This domain interacts with Ypt35 which recruits VPS13 to endosomal and vacuolar membranes, and with Mcp1 to target VPS13 at mitochondria. Defects in the human protein VPS13A cause chorea-acanthocytosis, an autosomal recessive neurodegenerative disorder. In plants, this domain is found to be the region which interacts with SHR or the SHORT-ROOT transcription factor, a regulator of root-growth and asymmetric cell division that separates ground tissue into endodermis and cortex. The plant protein containing the SHR-BD is named SHRUBBY or SHBY UniProt:Q9FT44.
Pfam PF24002: Family of unknown function (DUF7318) (family)
This entry represents uncharacterised archaeal proteins.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF24470: Isochorismatase, thioredoxin-like (domain)
This domain is found in a group of uncharacterised fungal proteins, including Isochorismatase from Colletotrichum graminicola. It is predicted to adopt a thioredoxin-like fold.
Pfam PF11142: Protein of unknown function (DUF2917) (family)
This bacterial family of proteins appears to be restricted to Proteobacteria.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF20320: Family of unknown function (DUF6615) (family)
This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 301 and 317 amino acids in length. These proteins contain a conserved sequence motif FREE that may be functionally important.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF22294: Domain of unknown function (DUF6966) (domain)
This is a domain found in uncharacterised bacterial proteins that is predicted to be helical. It contains a nearly invariant tryptophan toward the N terminus and a highly conserved motif [F/Y]GGMGSx(2)D toward the C-terminus.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF15894: Inhibitor of glucose uptake transporter SgrT (family)
SgrT is a small regulatory polypeptide that inhibits glucose transport activity by a yet unknown mechanism. It is part of a posttranscriptional regulation system in E. coli which consists of a small regulatory RNA (SgrS) and SgrT. During accumulation of glucose-6-phosphate or fructose-6-phosphate, SgrS is involved in downregulation of ptsG mRNA stability, whereas SgrT inhibits glucose transport .
Wikipedia: SgrS is a 227 nucleotide small RNA that is activated by SgrR in Escherichia coli during glucose-phosphate stress. The nature of glucose-phosphate stress is not fully understood, but is correlated with intracellular accumulation of glucose-6-phosphate. SgrS helps cells recover from glucose-phosphate stress by base pairing with ptsG mRNA and causing its degradation in an RNase E dependent manner. Base pairing between SgrS and ptsG mRNA also requires Hfq, an RNA chaperone frequently required by small RNAs that affect their targets through base pairing. The inability of cells expressing sgrS to create new glucose transporters leads to less glucose uptake and reduced levels of glucose-6-phosphate. SgrS is an unusual small RNA in that it also encodes a 43 amino acid functional polypeptide, SgrT, which helps cells recover from glucose-phosphate stress by preventing glucose uptake. The activity of SgrT does not affect the levels of ptsG mRNA of PtsG protein. It has been proposed that SgrT exerts its effects through regulation of the glucose transporter, PtsG.
Pfam PF05736: OprF membrane domain (domain)
This domain represents the presumed membrane spanning region of the OprF proteins. This region is involved in channel formation and is thought to form an 8-stranded beta-barrel.
Pfam PF17065: Putative cytokine, C6ORF120 (family)
C6orf120 is a secreted protein that promotes cell cycle progression of CD4(+) T-cells, not hepatocytes. In humans it has its main role in tunicamycin-induced CD4(+) T apoptosis that may be associated with endoplasmatic reticulum stress. This suggests that it might be a new cytokine with immununoregulatory function that is selective for CD4+ T cells. It is mainly expressed in hepatocytes and cells in germinal centre of lymph nodes.
Pfam PF01882: Protein of unknown function DUF58 (domain)
This family of prokaryotic proteins have no known function. [swissprot:P71138] a protein of unknown function in the family has been misannotated as alpha-dextrin 6-glucanohydrolase.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF07745: Glycosyl hydrolase family 53 (domain)
This domain belongs to family 53 of the glycosyl hydrolase classification.  These enzymes are enzymes are endo-1,4- beta-galactanases ([ec:3.2.1.89]). The structure of this domain is known and has a TIM barrel fold.
Wikipedia: In molecular biology, the glycoside hydrolase family 53 is a family of glycoside hydrolases EC 3.2.1., which are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycoside hydrolases, based on sequence similarity, has led to the definition of &gt;100 different families. This classification is available on the CAZy web site, and also discussed at CAZypedia, an online encyclopedia of carbohydrate active enzymes.
Pfam PF19842: YqeC protein (family)
This entry includes the E. coli YqeC protein. This protein belongs to the P-loop superfamily.
Pfam PF06566: Chondroitin sulphate attachment domain (domain)
This family represents the chondroitin sulphate attachment domain of vertebrate neural transmembrane proteoglycans that contain EGF modules. Evidence has been accumulated to support the idea that neural proteoglycans are involved in various cellular events including mitogenesis, differentiation, axonal outgrowth and synaptogenesis. This domain contains several potential sites of chondroitin sulphate attachment, as well as potential sites of N-linked glycosylation.
Pfam PF05472: DNA replication terminus site-binding protein (Ter protein) (family)
This family contains several bacterial Ter proteins. The Ter protein specifically binds to DNA replication terminus sites on the host and plasmid genome and then blocks progress of the DNA replication fork.
Wikipedia: In molecular biology, the ter site, also known as DNA replication terminus binding-site, refers to a protein domain which binds to the DNA replication terminus site. Ter-binding proteins are found in some bacterial species, and include the Tus protein which is part of the common Ter-Tus binding domain. They are required for the termination of DNA replication and function by binding to DNA replication terminator sequences, thus preventing the passage of replication forks. The termination efficiency is affected by the affinity of a particular protein for the terminator sequence.
Pfam PF09001: Domain of unknown function (DUF1890) (domain)
This domain is found in a set of hypothetical archaeal proteins.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF02652: L-lactate permease (family)
L-lactate permease is an integral membrane protein probably involved in L-lactate transport.
Wikipedia: The lactate permease (LctP) family is a family of transport proteins belonging to the ion transporter (IT) superfamily.
Pfam PF02074: Carboxypeptidase Taq (M32) metallopeptidase (family)
This group of metallopeptidases belong to MEROPS peptidase family M32 (carboxypeptidase Taq family, clan MA(E)). The predicted active site residues for members of this family and thermolysin, the type example for clan MA, occur in the motif HEXXH.
Over 70 metallopeptidase families have been identified to date. In these enzymes a divalent cation which is usually zinc, but may be cobalt, manganese or copper, activates the water molecule. The metal ion is held in place by amino acid ligands, usually three in number. In some families of co-catalytic metallopeptidases, two metal ions are observed in crystal structures ligated by five amino acids, with one amino acid ligating both metal ions. The known metal ligands are His, Glu, Asp or Lys. At least one other residue is required for catalysis, which may play an electrophillic role. Many metalloproteases contain an HEXXH motif, which has been shown in crystallographic studies to form part of the metal-binding site . The HEXXH motif is relatively common, but can be more stringently defined for metalloproteases as 'abXHEbbHbc', where 'a' is most often valine or threonine and forms part of the S1' subsite in thermolysin and neprilysin, 'b' is an uncharged residue, and 'c' a hydrophobic residue. Proline is never found in this site, possibly because it would break the helical structure adopted by this motif in metalloproteases .
Pfam PF00945: Rhabdovirus nucleocapsid protein (family)
The Nucleocapsid (N) Protein is said to have a "tight" structure. The carboxyl end of the N-terminal domain possesses an RNA binding domain. Sequence alignments show 2 regions of reasonable conservation,  approx. 64-103 and 201-329.  A whole functional protein is required  for encapsidation to take place.
Pfam PF01018: GTP1/OBG (domain)
The N-terminal domain of [swissprot:P20964] has the OBG fold, which is formed by three glycine-rich regions inserted into a small 8-stranded beta-sandwich these regions form six left-handed collagen-like helices packed and H-bonded together.
Pfam PF10137: CAP12/Pycsar effector protein, TIR domain (domain)
This entry represents a TIR domain found in prokaryotic nucleotide-binding proteins, including CD-NTase-associated protein 12 (CAP12) and Pycsar effector proteins (E.C:3.2.2.5). Members of this entry are part of anti phage resistance systems that provide immunity against bacteriophage. CAP12 is part of the CBASS (cyclic oligonucleotide-based anti phage signaling system) and binds c-di-GMP and 3'-3'-cGAMP, cyclic nucleotides synthesized by the CD-NTase protein in response to infection that serve as specific second messenger signals to activate a diverse range of effectors,  leading to bacterial cell death and thus abortive phage infection. Pycsar effector proteins are part of the Pycsar (pyrimidine cyclase system for anti phage resistance) and are activated by cyclic nucleotides produced by the pyrimidine cyclase (PycC) in response to infection. The TIR effector domain oligomerises and functions as NADase that deplete the cell of NAD+.
Pfam PF08001: CMV US (family)
This is a family of unique short (US) cytoplasmic glycoproteins which are expressed in cytomegalovirus.
Pfam PF20678: Herpesvirus Envelope glycoprotein GP350 C-terminal (domain)
This entry consists of the envelope glycoprotein gp350 from Epstein-Barr virus (also known as BLLF1 viral late glycoprotein). It is the most abundantly expressed glycoprotein in the viral envelope of Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo. It is a 907 residues long gp350 polypeptide containing an 18-residue peptide at the C-terminal that is located inside the viral membrane, a membrane-spanning domain and a large N-terminal segment (860 residues) predicted to extend outside the viral membrane. The extreme N-terminal region (1-470) is sufficient to bind receptor CR2 (also known as CD21) and fold into three distinct domains (denoted as A, B and C) which organise into an "L-shape" structure. This entry represents the C-terminal region of the Herpesvirus envelope glycoprotein GP350, which contains a IgK signal sequence (IgK SS), the TM domain and the short intracellular domain (IC).