SII-SWORD/CoKE huggingface dataset:
Pfam PF17039: Fucosyltransferase, N-terminal (domain)
This is the N-terminal domain of a family of fucosyltransferases. This enzyme transfers fucose from GDP-Fucose to GlcNAc in an alpha1,3 linkage. This family is known as glycosyltransferase family 10. The N-terminal domain is the likely binding-region for the fucose-like substrate (manuscript in publication).
Wikipedia: A fucosyltransferase is an enzyme that transfers an L-fucose sugar from a GDP-fucose donor substrate to an acceptor substrate. The acceptor substrate can be another sugar such as the transfer of a fucose to a core GlcNAc (N-acetylglucosamine) sugar as in the case of N-linked glycosylation, or to a protein, as in the case of O-linked glycosylation produced by O-fucosyltransferase. There are various fucosyltransferases in mammals, the vast majority of which, are located in the Golgi apparatus. The O-fucosyltransferases have recently been shown to localize to the endoplasmic reticulum (ER).
Pfam PF16424: Domain of unknown function (DUF5021) (family)
This family consists of Prepilin-type cleavage/methylation N-terminal domain proteins around 200 residues in length and is mainly found in various Eubacterium species. The function of this family is unknown.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF19016: Domain of unknown function (DUF5745) (domain)
This is a domain of unknown function found in Platyhelminthes. It shows homology with the calponin homology (CH) domain.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF18275: His-Me finger endonuclease beta4-alpha2 domain (domain)
This domain is found in Hpy991 present in Helicobacter pylori. Hpy991 is a beta-beta-alpha-Me restriction endonuclease that recognizes the CGWCG target sequence and cleaves both DNA strands with a stagger that leads to 5'-recessed ends in the cleavage products. This domain is the first of two beta4-alpha2 repeats found after the N-terminal domain. The two repeats have low overall sequence similarity but readily identified by a structural comparison. Both repeats contain contains two CXXC motifs that map to the first beta-hairpin and the first alpha-helix. The four cysteine residues coordinate a structurally bound Zn2+ ion tetrahedrally. The major groove is in contact with the first repeat, with the beta-hairpin 2 inserting deeply into the groove.
Pfam PF21116: Zip protein EF-hand (domain)
This entry represents an EF-hand like domain found in some Zip zinc transporters.ED   G3HHQ6.1/113-211;
Pfam PF03032: Frog skin active peptide family signal and propeptide (family)
This family contains a number of defence peptides secreted from the skin of amphibians, including the opiate-like dermorphins and deltorphins, and the antimicrobial dermoseptins and temporins. The alignment for this family consists of the signal peptide and propeptide regions and does not include the active peptides.Family members such as the peptide leucine arginine (pLR) belongs to a class of cyclic peptides isolated from frog skin. Its primary sequence is similar to the reactive loop of plant Bowman-Birk inhibitors (BBI), and the circular sunflower trypsin inhibitor-1 (SFTI-1) and to HV-BBI, an isolated peptide from amphibian skin with trypsin-inhibitory activity. pLR is a highly potent trypsin inhibitor, with therapeutic potential. A study describing immunomodulatory properties of pLR showed that the peptide is a potent activator of histamine release. Other members such as Phylloseptins are antimicrobial peptides of 19-20 residues and carry an amidated C-terminus.
Wikipedia: Amphibian antimicrobial peptides are a family of highly potent antimicrobial peptides with a large spectrum of activity, which are synthesized by vertebrates as an efficient host-defence mechanism against invading microorganisms. A number of these defence peptides are secreted from the skin of frogs and other amphibians, including the opiate-like dermorphins and deltorphins, and antimicrobial dermaseptins, temporins, bombinins, magainin, pseudin, bombesins, and maculatins.
Pfam PF20837: Major inner capsid protein P1 (family)
Major inner capsid protein P1 forms the inner T=1 shell of Bacteriophage phi-6, a dodecahedral polymerase complex (PC) that contains the three viral dsRNA segments. The protein folds into a flattened trapezoid shape with a mostly alpha-helical fold. It was initially though to adopt a funnel-shaped pentameric assembly, but later research has shown dimers of different P1 chains are also present in the virus capsid.
Pfam PF22820: TcaA protein 3rd/4th domain (domain)
This entry represents the third and fourth domains of the TcaA protein that adopt an Ig-like fold.
Pfam PF12647: RNHCP domain (domain)
This family of proteins is found in bacteria. Proteins in this family are typically between 94 and 143 amino acids in length. There is a conserved RNHCP sequence motif.
Pfam PF21652: YDR124W, N-terminal (domain)
This entry includes mitochondrial proteins of unknown function found in yeast. Null mutant showed severe fragmentation of mitochondria and its expression is strongly induced by alpha factor. Members of this entry may have a role in maintenance of mitochondrial morphology. This entry represents the N-terminal domain which may have an alpha/beta fold.
Pfam PF06512: Sodium ion transport-associated (family)
Members of this family contain a region found exclusively in eukaryotic sodium channels or their subunits, many of which are voltage-gated. Members very often also contain between one and four copies of [pfam:PF00520] and, less often, one copy of [pfam:PF00612].
Pfam PF09903: Uncharacterized protein conserved in bacteria (DUF2130) (family)
This domain, found in various hypothetical prokaryotic proteins, has no known function.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF11351: Holin of 3TMs, for gene-transfer release (family)
This is a family of bacterial 3TM holins. In Rhodobacter capsulatus the protein is expressed just overlapping and downstream of a putative N-acetylmuramidase lysozyme (an endolysin) thought to be responsible for lysing a phage particle, RcGTA - a gene-transfer agent. A holin would be necessary for such an endolysin to access the peptidoglycan. Gene-transfer agents are bacteriophage-like genetic elements with the sole known function of horizontal gene transfer, serving an important role in microbial evolution. In order to be released from the cell these require the combined action of an endolysin and this holin.
Pfam PF17825: Family of unknown function (DUF5587) (family)
This is a family of unknown function found in chordata.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF14364: Domain of unknown function (DUF4408) (family)
This domain is found at the N-terminus of member of the DUF761 family [pfam:PF05553]. Many members are plant proteins.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF19552: Family of unknown function (DUF6075) (family)
This family of proteins is functionally uncharacterised. This family of proteins is found primarily in Firmicute bacteria. Proteins in this family are typically between 130 and 155 amino acids in length. There is a conserved AFNL sequence motif.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF20770: PAN2 N-terminal (repeat)
The poly(A)-specific nuclease (PAN) is a deadenylating enzyme involved in cytoplasmic mRNA turnover consisting of two subunits, PAN2 and PAN3 that form a conserved complex which acts in the initial trimming of poly(A) tails during deadenylation, followed by the processive activity of CCR4-NOT complex. PAN2 has two independent structural units, the C-terminal catalytic unit (including [pfam:PF13423] and [pfam:PF00929]) and the N-terminal assembly unit, represented in this entry, which engages in a bipartite interaction with PAN3 dimers. This assembly unit contains a WD40 propeller that contacts the PAN3 C-terminal domain and it is connected to an adaptable linker which reinforces the asymmetry of the PAN3 dimer preventing the recruitment of a second PAN2 molecule.
Pfam PF11839: Alanine-zipper, major outer membrane lipoprotein (coiled_coil)
This is a family of a major outer membrane lipoprotein, OprL that is an alanine-zipper. Zipper motifs are a seven-repeat motif where the first and fourth positions are occupied by an aliphatic residue, usually a leucine. These residues are positioned on the outside of the coil such as to bind firmly to one or more monomers of the protein to create a triple or five-helical coiled-coil that probably forms a seam in a membrane.
Pfam PF08931: Lactophage receptor-binding protein C-terminal head domain (domain)
Caudo_bapla_RBP is a family of proteins expressed from ORF18 of the Lactococcus P2-like phage. This is one of three protein domains, shoulders, neck, and head, that form the phage tail base-plate. In the overall structure this head domain exists as six trimers, and is necessary for specific recognition of the receptors at the host cell surface. Siphoviridae are the P2-like Caudovirales of Lactococcus. This family now includes DUF1914. Family Baseplate, [pfam:PF16774], is the ORF15 or shoulder component of the base-plate complex.
Pfam PF15918: Domain of unknown function (DUF4744) (family)
This family of proteins is functionally uncharacterised. This family of proteins is found in eukaryotes. Proteins in this family are typically between 81 and 415 amino acids in length.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF03281: Mab-21 protein nucleotidyltransferase domain (domain)
This family contains Mab-21 and Mab-21 like proteins.  In C. elegans these proteins are required for several aspects of embryonic development.
Pfam PF10923: BREX system ATP-binding protein BrxC/D (domain)
This is the ATP-binding domain found in proteins that are associated with Bacteriophage Exclusion (BREX) system, a defense system that allows bacteriophage adsorption but blocks phage DNA replication. This domain is found in the ATP-binding proteins BrxC/pglY (due to its homology with pglY from Pgl system) and BrxD.
Wikipedia: AAA proteins are a large group of protein family sharing a common conserved module of approximately 230 amino acid residues. This is a large, functionally diverse protein family belonging to the AAA+ protein superfamily of ring-shaped P-loop NTPases, which exert their activity through the energy-dependent remodeling or translocation of macromolecules.
Pfam PF12603: RNA-directed RNA polymerase L, PA-C-like domain (domain)
This domain is found in RNA-directed RNA polymerase L from from Bunyavirales. It has been described as the PA-C-like domain which forms a narrow and positively charged cleft with the thumb domain, where the 3' RNA is likely bound. It is found in association with [pfam:PF04196].
Pfam PF20174: Family of unknown function (DUF6540) (family)
This entry contains a large diverse family of fungal proteins of unknown function.  They are predicted to adopt a globular structure that resembles the conserved core of the PPPDE superfamily (after Permuted Papain fold Peptidases of DsRNA viruses and Eukaryotes) consisting of thiol peptidases with a circularly permuted papain-like fold.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF09254: FokI, cleavage domain (domain)
Members of this family are predominantly found in prokaryotic restriction endonuclease FokI, and adopt a structure consisting of an alpha/beta/alpha core containing a five-stranded beta-sheet. They recognise the double-stranded DNA sequence 5'-GGATG-3' and cleave DNA phosphodiester groups 9 base pairs away on this strand and 13 base pairs away on the complementary strand. This entry represents the C-terminal cleavage domain of FokI.
Wikipedia: The restriction endonuclease Fok1, naturally found in Flavobacterium okeanokoites, is a bacterial type IIS restriction endonuclease consisting of an N-terminal DNA-binding domain and a non sequence-specific DNA cleavage domain at the C-terminal. Once the protein is bound to duplex DNA via its DNA-binding domain at the 5'-GGATG-3' recognition site, the DNA cleavage domain is activated and cleaves the DNA at two locations, regardless of the nucleotide sequence at the cut site. The DNA is cut 9 nucleotides downstream of the motif on the forward strand, and 13 nucleotides downstream of the motif on the reverse strand, producing two sticky ends with 4-bp overhangs.
Pfam PF07489: Translocated intimin receptor (Tir) C-terminus (domain)
Intimin and its translocated intimin receptor (Tir) are bacterial proteins that mediate adhesion between mammalian cells and attaching and effacing (A/E) pathogens. A unique and essential feature of A/E bacterial pathogens is the formation of actin-rich pedestals beneath the intimately adherent bacteria and localised destruction of the intestinal brush border. The bacterial outer membrane adhesin, intimin, is necessary for the production of the A/E lesion and diarrhoea. The A/E bacteria translocate their own receptor for intimin, Tir, into the membrane of mammalian cells using the type III secretion system. The translocated Tir triggers additional host signalling events and actin nucleation, which are essential for lesion formation. This family represents the Tir C-terminal domain  which has been reported to bind uninfected host cells and beta-1 integrins although the role of intimin binding to integrins is unclear. This intimin C-terminal domain has also been shown to be sufficient for Tir recognition.
Pfam PF01331: mRNA capping enzyme, catalytic domain (domain)
This family represents the ATP binding catalytic domain of the mRNA capping enzyme.
Pfam PF05688: Bacterial Immunoglobulin-like 21 (domain)
This entry represents BIg21(Bacterial Immunoglobulin-like 21) found in InvasinE (InvE). Invasins are members of the inverse autotransporter (IAT) family also referred to as type Ve secretion system. In general, they consist of an N-terminal beta-barrel-like domain, which is responsible for attachment of invasin to the outer membrane region of bacteria, repetitive Immunoglobuli-like (Ig) domains, which vary significantly in number among all the invasins, and the C-terminal domain/adhesion domain (AD) [pfam:PF05689], which provides invasins with the specificity to bind to its host target molecules. The overall structure of InvE shows that it comprises of three domain architecture in which the domains BIg20 (Bacterial Immunoglobulin-like 20) and BIg21 adopt two layer beta-sandwich fold resembling eukaryotic members of Immunoglobulin-superfamily (IgSF), while the AD is a globular, alpha/beta-domain. The structure of BIg21 belongs to the I2 set of IgSF with a unique modification in the C-E interstrand loop, important for its interaction with AD. BIg21 and AD form a functional super-domain as well, necessary to target the host receptor.
Pfam PF12611: Putative flagellar (family)
Proteins in this entry are encoded in a subset of  bacterial flagellar operons, generally between genes  designated flgD and flgE, in species as diverse as  Bacillus halodurans and various other Firmicutes,  Geobacter sulfurreducens, and Bdellovibrio bacteriovorus.
Pfam PF13200: Putative glycosyl hydrolase domain (domain)
This domain is related to other known glycosyl hydrolases suggesting this domain is also involved in carbohydrate break down.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF01536: Adenosylmethionine decarboxylase (family)
This is a family of S-adenosylmethionine decarboxylase (SAMDC) proenzymes.  In the biosynthesis of polyamines SAMDC produces decarboxylated S-adenosylmethionine, which serves as the aminopropyl moiety necessary for spermidine and spermine biosynthesis from putrescine. The Pfam alignment contains both the alpha and beta chains that are cleaved to form the active enzyme.
Pfam PF06749: Protein of unknown function (DUF1218) (family)
This family contains hypothetical plant proteins of unknown function. Family members contain a number of conserved cysteine residues.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF25085: Domain of unknown function (DUF7802) (domain)
This domain is found in uncharacterised bacterial and eukaryotic proteins. It is predicted to contain nine transmembrane helices arranged in a bundle. This domain has similarity to domains members of the INSIG-like superfamily.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF24948: ATP-citrate synthase ATP-grasp domain (domain)
The ATP-citrate synthase family is responsible for the synthesis of cytosolic acetyl-CoA, a crucial substrate for de novo lipid synthesis, including cholesterol and fatty acids. In animals, these enzymes typically have a homomeric structure, whereas in plants, they are composed of distinct alpha and beta chains. The family plays a central role in lipid metabolism, contributing to the elongation of fatty acids and the biosynthesis of various compounds such as isoprenoids and flavonoids. This family is characterized by its membership in the succinate/malate CoA ligase subunit families, with distinct N-terminal and C-terminal sections. This entry represents the N-terminal ATP-grasp domain.
Pfam PF00424: REV protein (anti-repression trans-activator protein) (family)
REV is a viral anti-repression trans-activator protein, which appears to act post-transcriptionally  to relieve negative repression of GAG and ENV production. It is a phosphoprotein  whose state of phosphorylation is mediated by a specific serine kinase activity present in the nucleus . REV accumulates in the nucleoli .
Wikipedia: Rev is a transactivating protein that is essential to the regulation of HIV-1 protein expression. A nuclear localization signal is encoded in the rev gene, which allows the Rev protein to be localized to the nucleus, where it is involved in the export of unspliced and incompletely spliced mRNAs. In the absence of Rev, mRNAs of the HIV-1 late (structural) genes are retained in the nucleus, preventing their translation.
Pfam PF20123: Family of unknown function (DUF6513) (family)
This presumed domain is functionally uncharacterised. This domain family is found in bacteria and archaea, and is typically between 75 and 86 amino acids in length.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF06525: Sulfocyanin (SoxE) domain (domain)
This family consists of several archaeal sulfocyanin (or blue copper protein) sequences from a number of Sulfolobus species.
Pfam PF12636: Protein of unknown function (DUF3781) (domain)
This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and archaea. Proteins in this family are typically between 82 and 98 amino acids in length. There are two conserved sequence motifs: GKNWY and ITA.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.