SII-SWORD/CoKE huggingface dataset:
Pfam PF11482: Protein of unknown function (DUF3208) (family)
This bacterial family of proteins has no known function.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF06638: Strabismus protein (family)
This family consists of several strabismus (STB) or Van Gogh-like (VANGL) proteins 1 and 2. The exact function of this family is unknown. It is thought, however that STB1 gene and STB2 may be potent tumour suppressor gene candidates.
Pfam PF17697: Family of unknown function (DUF5543) (family)
This is a family of unknown function found in primates.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF12450: von Willebrand factor (family)
This domain family is found in bacteria, and is approximately 100 amino acids in length. The family is found in association with [pfam:PF00092]. There are two conserved sequence motifs: STF and DVD.  There are two completely conserved residues (E and N) that may be functionally important. In hemostasis, platelet adhesion to the damaged vessel wall is mediated by several proteins, including von Willebrand factor. In solution vWF becomes immobilized via its A3 domain on the fibrillar collagen of the vessel wall and acts as an intermediary between collagen and the platelet receptor glycoprotein Ibalpha (GPIbalpha), which is the only platelet receptor that does not require prior activation for bond formation.
Pfam PF07802: GCK domain (domain)
This domain is found in proteins carrying other domains known to be involved in intracellular signalling pathways (such as [pfam:PF00071]) indicating that it might also be involved in these pathways. It has 4 highly conserved cysteine residues, suggesting that it can bind zinc ions. Moreover, it is found repeated in some members of this family (such as [swissprot:Q9LMF3]); this may indicate that these domains are able to interact with one another, raising the possibility that this domain mediates heterodimerisation.
Pfam PF20088: Family of unknown function (DUF6480) (family)
This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 75 and 88 amino acids in length.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF21860: Replitron, C-terminal domain (domain)
This entry represents a presumed domain found adjacent to the HUH endonuclease domain of the eukaryotic transposase encoded by Replitron, a fourth independent group of DNA transposons encoding HUH endonuclease that are found in genomes of green algae and plants, diverse stramenopiles including brown seaweeds and likely also cryptophytes and haptophytes, which suggests an ancient origin and broad eukaryotic distribution. According to structure predictions from AlphaFold DB, and structural similarities with related Rep HUH endonucleases (PDBe:8AMV), this may be an oligomerisation domain.
Pfam PF12314: Inner membrane complex protein (family)
This domain is found in bacteria and eukaryotes. This domain is about 120 amino acids in length. This family is the inner membrane complex of parasitic organisms. This is a cytoskeletal structure associated with the pellicle of these parasites.
Pfam PF04006: Mpp10 protein (family)
This family includes proteins related to Mpp10 (M phase phosphoprotein 10). The U3 small nucleolar ribonucleoprotein (snoRNP) is required for three cleavage events that generate the mature 18S rRNA from the pre-rRNA. In Saccharomyces cerevisiae, depletion of Mpp10, a U3 snoRNP-specific protein, halts 18S rRNA production and impairs cleavage at the three U3 snoRNP-dependent sites.
Pfam PF14496: C-terminal novel E3 ligase, LRR-interacting (domain)
This NEL or novel E3 ligase domain is found at the C-terminus of bacterial virulence factors. Its sequence is different from those of the eukaryotic HECT and RING-finger E3 ligases, and it subverts the host ubiquitination process. At the N-terminus of the family-members there is a series of LRR repeats, and the NEL domain interacts with the most N-terminal repeat. The key residue for the ligation step is the cysteine, eg found at position 386 in UniProtKB:E7K2H2. The LRR section sequesters this active site until invasion has occurred.
Pfam PF20131: ABC-three component (ABC-3C) system Middle Component 3 (family)
Middle Components (MCs) of the ABC-3C biological conflict systems occupy the central position between the catalytic effector and ABC ATPases of the systems. MCs are defined by distinctive patterns of conserved charged residues. As some MCs are HTH domains, they are predicted to function akin to kleisins as DNA-binding partners for the ABC ATPases, assisting in recognition and responding to invasive elements such as DNA viruses.
Pfam PF13152: Protein of unknown function (DUF3967) (family)
This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 173 and 249 amino acids in length.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF18974: Domain of unknown function (DUF5710) (domain)
This is a domain of unknown function which can be found in DNA primases such as TraC.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF19005: Domain of unknown function (DUF5734) (domain)
This is a conserved domain found in various Platyhelminthes. The function of this family is still unknown.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF07355: Glycine/sarcosine/betaine reductase selenoprotein B (GRDB) (domain)
This family represents a conserved region approximately 350 residues long within the selenoprotein B component of the bacterial glycine, sarcosine and betaine reductase complexes.
Pfam PF22068: Androglobin, domain II (domain)
Androglobin is a protein with a key role in spermatogenesis. It is required for sperm flagellum formation and maturation of elongating spermatids, both essential for male fertility. Androglobin contains an N-terminal cysteine protease domain that lacks the catalytic cysteine, a tandem of three beta-sandwich domains (domains II,|V,V) and a circularly permuted globin-like domain (domain III) that is inserted between domain II and |V. This entry represents domain II. This domain is predicted to adopt a jelly-roll topology that is observed in galactose-binding domains. It has a significant sequence similarity to domains found in ciliary protein FAP42 and to domain III in calpains.
Pfam PF13874: Nucleoporin complex subunit 54 (domain)
This is the human Nup54 subunit of the nucleoporin complex, equivalent to Nup57 of yeast. Nup54, Nup58 and Nup62 all have similar affinities for importin-beta. It seems likely that they are the only FG-repeat nucleoporins of the central channel, and as such they would form a zone of equal affinity spanning the central channel.  The diffusion of importin-beta import complexes through the central channel may be a stochastic process as the affinities are similar, whereas movement from cytoplasmic fibrils to the central channel and from the central channel to the nuclear basket would be facilitated by the subtle differences in affinity between them.
Pfam PF10937: Alpha-ketoglutarate dehydrogenase component 4/YMR-31 (family)
This entry represents the alpha-ketoglutarate dehydrogenase component 4 (Kgd4, also referred to as Ymr31/MRPS36) which was originally identified as a subunit of the mitochondrial ribosome. Through biochemical studies, it was shown that this protein co purifies with the oxoglutarate dehydrogenase complex (OGDC). Both mitochondrial ribosome 28S subunit and OGDC have a similar size and OGDC is highly abundant, being found to contaminate ribosomal preparations. Kgd4 plays an evolutionarily conserved role in the organisation of mitochondrial alpha-KGDH complexes of fungi and animals which constitutes a molecular adaptor that is necessary to form a stable alpha-KGDH enzyme complex.
Pfam PF16613: Unstructured region of RGS12 (disordered)
RGS12_us1 is a region of Regulator of G-protein signalling 12 proteins that is natively unstructured and lies N-terminal to other such regions in UniProt:E1BPP4.  It is very glycine-rich, and the function is not known.
Pfam PF21978: Transcriptional regulator SEHBP (family)
This protein family represents human Transcriptional regulator SEHBP (short ORF-encoded histone binding protein), a conserved microprotein that interacts with chromatin-associated proteins and acts as a transcription factor.
Pfam PF06594: Haemolysin-type calcium binding protein related domain (repeat)
This family consists of a number of bacteria specific domains which are found in haemolysin-type calcium binding proteins. This family is found in conjunction with [pfam:PF00353] and is often found in multiple copies.
Pfam PF03512: Glycosyl hydrolase family 52 (family)
O-Glycosyl hydrolases (3.2.1.) are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycosyl hydrolases, based on sequence similarity, has led to the definition of 85 different families . This classification is available on the CAZy (CArbohydrate-Active EnZymes) website.
Glycoside hydrolase family 52 GH52 comprises enzymes with only one known activity; beta-xylosidase (3.2.1.37).

Proteins harboring beta-xylosidase and xylanase activities have been identified in the Gram-positive, facultative thermophilic aerobe Bacillus stearothermophilus 21 . This microbe, which functions in xylan degradation, can utilise xylan as a sole source of carbon. The enzyme hydrolyses 1,4-beta-D-xylans, removing successive D-xylose residues from the non-reducing termini. It also hydrolyses xylobiose.
Wikipedia: In molecular biology, glycoside hydrolase family 52 is a family of glycoside hydrolases.
Pfam PF18163: SLOG cluster2 (family)
Family in the SLOG superfamily, observed associating with distinct effector domains including the patatin lipase or a protein containing one enzymatically active and one inactive copy of the TIR domain.
Pfam PF24634: Domain of unknown function (DUF7631) (domain)
This presumed domain is found in uncharacterised sequences from Plasmodium falciparum and similar sequences from Apicomplexa. This domain may adopt a TNF receptor-like fold.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF12185: Nup358/RanBP2 E3 ligase domain (domain)
This domain family is found in eukaryotes, and is approximately 60 amino acids in length. The family is found in association with [pfam:PF00638], [pfam:PF00641], [pfam:PF00160]. There are two conserved sequence motifs: TFFC and EDF. Nup358/RanBP2 is a nucleoporin involved in ubiquitination of many different protein targets from various cellular pathways. It complexes with Ubc9, SUMO-1 and RanGAP1 to perform this function. This is the ligase domain which binds to Ubc9.
Pfam PF10318: Serpentine type 7TM GPCR chemoreceptor Srh (family)
Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srh is part of the Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.
Pfam PF22600: Poly(A) RNA polymerase, mitochondrial-like, central palm domain (domain)
This domain is found in human Poly(A) RNA polymerase, mitochondrial (MTPAP) and similar proteins from eukaryotes. MTPAP is a noncanonical polymerase that creates the 3' poly(A) tail of mitochondrial transcripts. It contains three domains: a N-terminal domain RL ([pfam:PF17797]) and the canonical palm (this entry) and fingers domains. This domain shows a five -stranded beta-sheet with the three catalytic aspartic acid residues located on its surface, together with several alpha- helices, forming an alpha-beta configuration.
Pfam PF17695: Family of unknown function (DUF5541) (family)
This is a family of unknown function found in primates.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF20800: Xanthomonas phage Xp10 Transcription regulator P7 (family)
Transcription regulator P7 from Xanthomonas phage Xp10 interacts with the RNA polymerase (RNAP) from bacteria: it prevents transcription termination and inhibits transcription initiation. This protein adopts a compact globular form comprising an alpha-helix packed against a beta-sheet.
Pfam PF06056: Putative ATPase subunit of terminase (gpP-like) (family)
This family of proteins are annotated as ATPase subunits of phage terminase after. Terminases are viral proteins that are involved in packaging viral DNA into the capsid.
Pfam PF22347: Avirulence protein AvrPiz-t (domain)
This entry represents avirulence protein AvrPiz-t from Magnaporthe oryzae. It is predicted to be secreted and it can suppress programmed cell death (PCD) induced by BAX in tobacco which suggests that it might contribute to the pathogenicity of M.oryzae.
Pfam PF14817: HAUS augmin-like complex subunit 5 (family)
This family includes HAUS augmin-like complex subunit 5. The HAUS augmin-like complex contributes to mitotic spindle assembly, maintenance of chromosome integrity and completion of cytokinesis.
Pfam PF04110: Ubiquitin-like autophagy protein Apg12 (domain)
In yeast, 15 Apg proteins coordinate the formation of autophagosomes.  Autophagy is a bulk degradation process induced by starvation in eukaryotic cells. The Apg12 system is one of the ubiquitin-like protein conjugation systems conserved in eukaryotes. It was first discovered in yeast during systematic analyses of the apg mutants defective in autophagy. Covalent attachment of Apg12-Apg5 is essential for autophagy.
Pfam PF10892: Protein of unknown function (DUF2688) (family)
Members in this family of proteins are annotated as KleB however currently no function is known.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF11226: Protein of unknown function (DUF3022) (family)
This family of proteins with unknown function appears to be restricted to Proteobacteria.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF04248: Domain of unknown function (DUF427) (domain)
This domain contains a beta-tent fold.
Pfam PF21764: Invasin, domain 4 (domain)
This domain is found in a group of proteins from Gammaproteobacteria, including Invasin from Yersinia pseudotuberculosis, a protein that allows this enteric bacteria to penetrate cultured mammalian cells by binding several beta-1 chain integrins. This domain adopts the folding topology of the C1 set of IgSF domains with two additional beta-strands.
Pfam PF08568: Uncharacterised protein family, YAP/Alf4/glomulin (repeat)
This entry contains a number of protein families with apparently unrelated functions. These include the YAP binding proteins of yeasts. These are stress response and redox homeostasis proteins, induced by hydrogen peroxide or induced in response to alkylating agent methyl methanesulphonate (MMS). The family includes Aberrant root formation protein 4 (Alf4) of Arabidopsis thaliana (Mouse-ear cress), which is required for the initiation of lateral roots independent from auxin signalling. It may also function in maintaining the pericycle in the mitotically competent state needed for lateral root formation. The family includes glomulin (FAP68), which is essential for normal development of the vasculature and may represent a naturally occurring ligand of the immunophilins FKBP59 and FKBP12.
Pfam PF16452: Bacteriophage CI repressor C-terminal domain (domain)
The C-terminal domain of the CI repressor functions in oligomer formation.
Pfam PF16436: Domain of unknown function (DUF5033) (family)
This family consists of several uncharacterized proteins around 200 in length and is mainly found in various Bacteroides species. The function of this family is unknown.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF13778: Domain of unknown function (DUF4174) (family)
This domain of unknown function is found in a putative tumour suppressor gene and in a ligand for the the urokinase-type plasminogen activator receptor, which plays a role in cellular migration and adhesion.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF12708: Rhamnogalacturonase A/epimerase, pectate lyase-like (repeat)
This domain posses a beta-helical structure like pectate lyase, found in a varied group of proteins including D-mannuronate C5-epimerases and glycosyl hydrolases from GH family 28. This domain is also found in non-secreted LysM effector LysM15 and LysM19 from Penicilliumm expansum, which might be involved in manipulation of host defences for successful infection.
Pfam PF24656: CEP76 peptidase-like domain (domain)
This entry represents a domain found in the middle of centrosomal protein of 76 kDa, a protein involved in regulation of centriole duplication to limit centriole duplication to once per cell cycle by preventing centriole reduplication. This domain is also found at the C-terminal of C2D2A/B, whose function is unknown, and in dynein regulatory complex subunit 7 (DRC7). In DRC7, this model covers the C-terminal part of the domain as it has an insertion not present in the other members of the entry.  This domain is may adopt a fold related to peptidases.
Pfam PF03053: ORF3b coronavirus protein (family)
Members of this family are non-structural proteins, approximately 250 amino acid residues long. They are found in transmissible gastroenteritis coronavirus (TGEV) and porcine respiratory coronavirus (PRCV) isolates. These proteins are found on the same mRNA as another product, designated ORF3a. While ORF3a/b has been implicated in TGEV and PRCV pathogenesis, its precise role remains unclear (see).
Pfam PF13276: HTH-like domain (domain)
This domain contains a predicted helix-turn-helix suggesting a DNA-binding function.
Pfam PF04959: Arsenite-resistance protein 2 (family)
Arsenite is a carcinogenic compound which can act as a co-mutagen by  inhibiting DNA repair. Arsenite-resistance protein 2 is thought to play a role in arsenite resistance.
Pfam PF25016: Pikachurin, EGF-like domain (domain)
This EFG-like domain is found in human Pikachurin, which is involved in both the retinal photoreceptor ribbon synapse formation and physiological functions of visual perception. The fold of this domain consists of a two stranded beta-sheet followed by a loop and a short two-stranded sheet.
Pfam PF16128: Domain of unknown function (DUF4840) (family)
This family consists of uncharacterized proteins around 220 residues in length and is mainly found in various Bacteroides species. The function of this family is unknown.
Pfam PF23951: Domain of unknown function (DUF7282) (domain)
This domain is found in uncharacterised bacterial and archaeal proteins. It is predicted to adopt a beta-sandwich with an Ig-like topology, similar to domains members of clan CL0073. Some proteins contain multiple copies of this domain.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.