SII-SWORD/CoKE huggingface dataset:
Pfam PF01567: Hantavirus glycoprotein Gn, head (domain)
The medium (M) genome segment of hantaviruses (family Bunyaviridae) encodes the two virion glycoproteins, Gn and Gc (also known as G1 and G2, respectively), as a polyprotein precursor. Gn and Gc forms homotetramers (spikes) at the surface of the virion which attach the virion to host cell receptors including integrin beta3/ITGB3 induce internalisation, predominantly through clathrin-dependent endocytosis. This entry represents the N-terminal two-thirds of the Gn glycoprotein ectodomain, denoted as 'head' (Gn-H) which interacts with Gc ectodomain. Release of Gn-H at acid pH induces a further conformational change of the Gc domain II tip which exposes non-polar side chains for insertion into the endosomal membrane.
Pfam PF20591: Domain of unknown function (DUF6792) (domain)
This presumed domain is functionally uncharacterised. This domain is found in bacteria, and is around 250 amino acids in length. There is a conserved sequence motif GHSLGG. It may have an alpha/beta hydrolase fold suggesting a catalytic role.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF23782: Twisted gastrulation (Tsg) protein N-terminal domain (domain)
This entry represents the N-terminal helical domain of Tsg.  Tsg was identified in Drosophila as being required to specify the dorsal-most structures in the embryo, for example amnioserosa. Biochemical experiments have revealed three key properties of Tsg: it can synergistically inhibit Dpp/BMP action in both Drosophila and vertebrates by forming a tripartite complete between itself, SOG/chordin and a BMP ligand; Tsg seems to enhance the Tld/BMP-1-mediated cleavage rate of SOG/chordin and may change the preference of site utilisation; Tsg can promote the dissociation of chordin cysteine-rich-containing fragments from the ligand to inhibit BMP signalling.
Pfam PF16136: Putative nuclear localisation signal in Ninja/AFP proteins (conserved_site)
This entry represents a likely nuclear localisation motif that is found in the plant NINJA and AFP proteins.  NINJA proteins are Novel INteractor of JAZ proteins found in plants.  NINJA proteins act as a transcriptional repressor, the activity of which is mediated by a functional TPL-binding EAR repression motif upstream from this domain.
Pfam PF21316: TPPII, galactose-binding domain-like (domain)
Tripeptidyl peptidase II (TPP II) is a large eukaryotic protease that acts downstream of the 26S proteasome and releases N-terminal tripeptides from polypeptides. It consists of three main parts: the N-terminal subtilisin-like domain ([pfam:PF00082]), a central domain and a C-terminal domain ([pfam:PF12583]). According to the structures, the central domain can be subdivided into Ig-like and galactose-binding domain-like (GBD). This entry represents the GBD segment of TPPII central domain.
Pfam PF14865: Macin (domain)
The macins are antimicrobial proteins. They form a disulphide-stabilised alpha-beta motif.
Pfam PF10693: Protein of unknown function (DUF2499) (family)
Members of this family are found in plants, lower eukaryotes, and bacteria and the chloroplast where it is annotated as Ycf49 or Ycf49-like.  The function is not known though several members are annotated as putative membrane proteins.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF03298: Stanniocalcin family (family)
Stanniocalcin (STC) is a calcium-and phosphate-regulating hormone produced in bony fish by the corpuscles of Stannius, which are located close to the kidney. It is a major antihypercalcemic hormone in fish. Recent results suggest that the biological repertoires of STCs in mammals will be considerably larger than in fish and may not be limited to mineral metabolism .
Pfam PF10195: DNA-binding nuclear phosphoprotein p8 (family)
P8 is a short 80-82 amino acid protein that is conserved from nematodes to humans. It carries at least one protein kinase C domain suggesting a possible role in signal transduction and it is thought to be a phosphoprotein, but the sites of phosphorylation and the kinases involved remain to be determined.
Pfam PF07454: Stage II sporulation protein P (SpoIIP) (family)
This family contains the bacterial stage II sporulation protein P (SpoIIP) (approximately 350 residues long). It has been shown that a block in polar cytokinesis in Bacillus subtilis is mediated partly by transcription of spoIID, spoIIM and spoIIP. This inhibition of polar division is involved in the locking in of asymmetry after the formation of a polar septum during sporulation. Engulfment in Bacillus subtilis is mediated by two complementary systems: the first includes the proteins SpoIID, SpoIIM and SpoIIP (DMP) which carry out the engulfment, and the second includes the SpoIIQ-SpoIIIAGH (Q-AH) zipper, that recruits other proteins to the septum in a second-phase of the engulfment. The course of events follows as the incorporation firstly of SpoIIB into the septum during division to serve directly or indirectly as a landmark for localising SpoIIM and then SpoIIP and SpoIID to the septum. SpoIIP and SpoIID interact together to form part of the DMP complex. SpoIIP itself has been identified as an autolysin with peptidoglycan hydrolase activity.
Pfam PF10376: Double-strand recombination repair protein (family)
Mei5 is one of a pair of meiosis-specific proteins which facilitate the loading of Dmc1 on to Rad51 on DNA at double-strand breaks during recombination. Recombination is carried out by a large protein complex based around the two RecA homologues, Rad51 and Dmc1. This complex may play both a catalytic and a structural role in the interaction between homologous chromosomes during meiosis. Mei5 is seen to contain a coiled-coli region.
Pfam PF20772: TACO1/YebC protein N-terminal domain (domain)
This entry represents the N-terminal helical bundle domain from proteins in the TACO1/YebC family which are thought to act as transcriptional regulators. In mammals, The TACO1 protein activates the translation of mitochondrially-encoded COX1. In bacteria, it negatively regulates the quorum-sensing response regulator by binding to its promoter region.
Pfam PF21849: Domain of unknown function (DUF6908) (domain)
This family of proteins are uncharacterised.  This family is distantly related to [pfam:PF06853] currently known as DUF1249.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF23466: WWE domain (domain)
This entry represents a WWE domain found in the ARTD/PARP family. The ARTD/PARP family proteins are characterized by their involvement in post-translational modifications and antiviral responses. Members of this family, such as PARP12, function as mono-ADP-ribosyltransferases, modifying target proteins with ADP-ribose. This modification can impact various cellular processes, including signal transduction, DNA repair, and gene expression. Other members, like the Zinc finger CCCH-type antiviral proteins (ZAP), exhibit a divergent PARP homology domain that is structurally incapable of binding NAD[+] and is thus enzymatically inactive.  However, ZAP proteins play a crucial role in antiviral defense by binding to viral RNAs and targeting them for degradation. They recruit cellular machineries such as the exosome complex, PARN, and the DCP1-DCP2 decapping complex to degrade viral mRNAs from both ends, effectively inhibiting viral replication. The family's antiviral function extends to a variety of viruses, including retroviruses and filoviruses, by recognizing specific RNA elements and initiating a host immune response.
Pfam PF16649: Interleukin 23 subunit alpha (domain)
This family, interleukin 23 subunit alpha, is a heterodimer consisting of a 40 kDa subunit - p40 - that is shared with IL12 and a unique 19 kDa subunit - p19. IL23 is a pro-inflammatory cytokine that binds to adnectins and thus plays a key role in the pathogenesis of several autoimmune and inflammatory diseases. IL23 signalling on the cell membrane works through the interaction of four proteins, two of which are shared with the IL12-receptor complex; signalling through the cell membrane involves the combined aggregation of at least two receptor components and then the subsequent activation of the Jak/Tyk tyrosine kinases and the family of STAT transcription factors.
Pfam PF12390: Selenocysteine synthase N terminal (family)
This domain family is found in bacteria, and is approximately 40 amino acids in length. The family is found in association with [pfam:PF03841].  There is a single completely conserved residue P that may be functionally important. This family is the N terminal region of selenocysteine synthase which catalyses the conversion of seryl-tRNA(Sec) into selenocysteyl-tRNA(Sec).
Pfam PF06615: Circovirus 2, Orf1 (family)
This family consists of short Circovirus proteins of unknown function, including ORF1 (also known as Protein NS0) which may be involved in host modulation.
Pfam PF01600: Coronavirus spike glycoprotein S1 (family)
This family represents the spike glycoprotein (S) of coronaviruses. The spike protein is arranged in trimers on the surface of the  viral membrane and is essential for viral entry. The spike protein  is translated as a large polypeptide that is subsequently cleaved  to the distal S1, responsible for receptor binding, and the  membrane-anchored S2 responsible for membrane fusion. The  coronavirus (SARS-CoV) S1 subunit is composed of two distinct  domains: an N-terminal domain (S1 NTD) and a receptor-binding  domain (S1 RBD) also referred to as the S1 CTD or domain B. Each  of these domains have been implicated in binding to host receptors.  However, most coronaviruses are not known to utilise both the S1  NTD and S1 RBD for viral entry. This entry contains spike  protein from both alpha and gamma coronaviruses but excludes the  spike protein from beta-coronaviruses such as SARS-CoV.
Pfam PF16986: Heavy-metal resistance protein CzcE (domain)
CzcE is involved in heavy-metal resistance. It binds copper, which induces a conformational change.
Pfam PF04443: Acyl-protein synthetase, LuxE (family)
LuxE is an acyl-protein synthetase found in bioluminescent bacteria.  LuxE catalyses the formation of an acyl-protein thioester from a fatty acid and a protein. This is the second step in the bioluminescent fatty acid reduction system, which converts tetradecanoic acid to the aldehyde substrate of the luciferase-catalysed bioluminescence reaction A conserved cysteine found at position 364 in Photobacterium phosphoreum LuxE ([swissprot:Q52100]) is thought to be acylated during the transfer of the acyl group from the synthetase subunit to the reductase.  The carboxyl terminal of the synthetase is though to act as a flexible arm to transfer acyl groups between the sites of activation and reduction. This family also includes Vibrio cholerae RBFN protein ([swissprot:Q06961]), which is involved in the biosynthesis of the O-antigen component 3-deoxy-L-glycero-tetronic acid.
Pfam PF05813: Orthopoxvirus F7 protein (family)
This entry represents Protein F7L from Vaccinia virus, also known as Protein OPG051, and similar sequences mainly found in orthopoxvirus. The function of the orthopoxvirus F7L proteins are unknown.
Pfam PF09659: Cas_Csm6 HEPN domain (domain)
This entry represents the HEPN domain of Csm6 from bacteria (i.e Enterococcus italicus), a Cas (CRISPR-associated) protein from type III-A CRISPR-Cas system. It consists of a CARF domain at the N-terminal, a six-helix domain and a C-terminal HEPN domain at the C-terminal, which has RNase activity.
Pfam PF22702: Cas9 RuvC domain (domain)
This entry represent a RuvC endonuclease domain (RNAseH-like) domain found in CRISPR-Cas9 from Streptococcus pyogenes and related sequences. This domain, and the HNH ([pfam:PF13395]) domain of Cas9, are used to cleave the DNA strands complementary (target) and non-complementary (non-target) to the crRNA, respectively. This domain is related to [pfam:PF18541].
Pfam PF16849: Glycosyltransferase family 88 (domain)
This is a family of type A glycosyltransferases found in Legionella. It acts as a virulence factor by the glucosylation of EF1A (elongation factor 1A) thereby blocking protein synthesis in the host cell.
Pfam PF06446: Hepcidin (domain)
Hepcidin is a antibacterial and antifungal protein expressed in the liver and is also a signaling molecule in iron metabolism. The hepcidin protein is cysteine-rich and forms a distorted beta-sheet with an unusual disulphide bond found at the turn of the hairpin.
Wikipedia: Hepcidin is a protein that in humans is encoded by the HAMP gene. Hepcidin is a key regulator of the entry of iron into the circulation in mammals.
Pfam PF01834: XRCC1 N terminal domain (domain)
DNA-repair protein Xrcc1 functions in the repair of single-strand DNA breaks in mammalian cells and forms a repair complex with beta-Pol, ligase III and PARP . The NMR solution structure of the Xrcc1 N-terminal domain (Xrcc1 NTD) shows that the structural core is a Î²-sandwich with Î²-strands connected by loops, three helices and two short two-stranded Î²-sheets at each connection side. The Xrcc1 NTD specifically binds single-strand break DNA (gapped and nicked) and a gapped DNA-beta-Pol complex .
Wikipedia: DNA repair protein XRCC1, also known as X-ray repair cross-complementing protein 1, is a protein that in humans is encoded by the XRCC1 gene. XRCC1 is involved in DNA repair, where it complexes with DNA ligase III.
Pfam PF17023: Domain of unknown function (DUF5098) (family)
This is family of microsporidia-specific sequences with no known function. There is a very characteristic NPW sequence motif at the very C-terminus.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF12363: Phage tail assembly chaperone protein, TAC (family)
This is a family of phage tail assembly chaperone proteins from Siphoviridae phages.
Pfam PF17500: Colicin-K immunity (family)
Colicins are bacterial toxins produced by Escherichia coli strains and are active against E. coli or related strains. These bacterial antibiotic toxins play an important role in the E. coli colonization of environmental niches. Colicin K uses the Tsx nucleoside-specific  receptor for binding at the cell surface, the OmpA protein for  translocation through the outer membrane, and the TolABQR proteins  for the transit through the periplasm. The N-terminal domain  interacts with components of its import machinery, including the  TolB and TolQ proteins. Members of this family are colicin K  immunity proteins. These proteins are able to protect a cell against  colicin K.
Pfam PF12167: Arm DNA-binding domain (domain)
This domain is found at the N-terminus of various phage integrases. The domain binds to DNA.
Pfam PF20766: Protein of unknown function (DUF447) (domain)
This entry represents a spectrin-like domain found in the DUF447 family of proteins.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF19112: Vanillate O-demethylase oxygenase C-terminal domain (domain)
This domain is found in a wide variety of oxygenases such as Vanillate O-demethylase oxygenase and Toluene-4-sulfonate monooxygenase.
Pfam PF11150: Protein of unknown function (DUF2927) (family)
This family is conserved in Proteobacteria.  Several members are described as being putative lipoproteins, but otherwise the function is not known.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF24301: Filament integrity protein FraC (family)
This entry represents the Filament integrity protein FraC and related proteins found in cyanobacteria. FraC, along with FraD and SepJ (FraG), is found at intercellular septa in heterocyst -forming filamentous cyanobacteria such as Nostoc punctiforme. This protein is involved in filament integrity and is required for the integrity of cell junctions in general.
Pfam PF05847: Nucleopolyhedrovirus late expression factor 3 (LEF-3) (family)
This family consists of LEF-3 Nucleopolyhedrovirus late expression factor 3 (LEF-3) sequences which are known to be ssDNA-binding proteins.  Alkaline nuclease (AN) and LEF-3 may participate in homologous recombination of the baculovirus genome in a manner similar to that of exonuclease (Redalpha) and DNA-binding protein (Redbeta) of the Red-mediated homologous recombination system of bacteriophage lambda. LEF-3 is essential for transporting the putative baculovirus helicase protein P143 into the nucleus where they function together during viral DNA replication. LEF-3 and other proteins have been shown to bind to closely linked sites on viral chromatin in vivo, suggesting that they may form part of the baculovirus replisome.
Pfam PF08573: DNA endonuclease activator SAE2/CtIP C-terminus (domain)
SAE2 is a protein involved in repairing meiotic and mitotic double-strand breaks in DNA. It has been shown to negatively regulate DNA damage checkpoint signalling. SAE2 is homologous to the CtIP proteins in mammals and an homologous protein in plants. Crucial sequence motifs that are highly conserved are the CxxC and the RHR motifs in this C-terminal part of the protein. In budding yeast, genetic evidence suggests that the SAE2 protein is essential for the processing of hairpin DNA intermediates and meiotic double-strand breaks by Mre11/Rad50 complexes. SAE2 binds DNA and exhibits endonuclease activity on single-stranded DNA independently of Mre11/Rad50 complexes, but hairpin DNA structures are cleaved cooperatively in the presence of Mre11/Rad50 or Mre11/Rad50/Xrs2. Hairpin structures are not processed at the tip by SAE2 but rather at single-stranded DNA regions adjacent to the hairpin. The catalytic activities of SAE2 are important for its biological functions. Although proteins containing this domain were described as endonucleases, it is now known that they actually function as endonuclease activators. This domain contains highly conserved residues at its 15-residue extreme that are indispensable for MRN (Mre11-Rad50-Nbs1) complex activation, through the stimulation of Mre11 endonuclease activity.
Pfam PF19413: YaiO membrane beta barrel domain (domain)
This entry represents a domain of bacterial outer membrane beta barrel fro the YaiO protein. YaiO was experimentally shown to be localised to the outer membrane.
Pfam PF14322: Starch-binding associating with outer membrane (repeat)
SusD is a secreted polysaccharide-binding protein with an N-terminal lipid moiety that allows it to associate with the outer membrane. SusD probably mediates xyloglucan-binding prior to xyloglucan transport in the periplasm for degradation. This domain is found N-terminal to [pfam:PF07980].
Pfam PF16502: Domain of unknown function (DUF5059) (family)
This domain is found fused to a copper-binding protein at the C-terminus, family Copper-bind, [pfam:PF00127]. Its function is not known, and it is found in the Halobacteriaceae family in Archaea.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF22635: Intron-associated endonuclease 1 zinc finger domain (domain)
This entry represent the unusual zinc finger domain present in the -ntron-associated endonuclease 1 (I-TevI), which comprises the unusual sequence CXCX10CXXC. The Zn finger interacts with the DNA through two hydrogen bonds, between the main chain nitrogen atoms of residues Tyr162 and Ser165.
Pfam PF19220: Crescentin protein (coiled_coil)
This entry represents a bacterial equivalent to Intermediate Filament proteins, named crescentin, whose cytoskeletal function is required for the vibrioid and helical shapes of Caulobacter crescentus. Without crescentin, the cells adopt a straight-rod morphology. Crescentin has characteristic features of IF proteins including the ability to assemble into filaments in vitro without energy or cofactor requirements. In vivo, crescentin forms a helical structure that colocalizes with the inner cell curvatures beneath the cytoplasmic membrane.
Pfam PF06140: Interferon-induced 6-16 family (family)
This entry represents interferon alpha-inducible proteins IFI6 (also known as IFI-6-16) and IFI27-like (also known as ISG12) which play a role in the apoptotic process and also have pro-apoptotic activity . ISG12a is a mitochondrial protein that contributes to IFN-induced apoptosis through perturbation of normal mitochondrial function .
Pfam PF17431: Uncharacterized YmpT-like (family)
This is a family of unknown function found in Bacillus.
Pfam PF14628: Domain of unknown function (DUF4454) (family)
This C-terminal domain is found only on a small subgroup of proteins from Gram-positive Clostridiales that also carry a YARHG domain, [pfam:PF13308].
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF16167: Domain of unknown function (DUF4871) (family)
This family consists of uncharacterized proteins around 170 residues in length and is mainly found in various Bacillus species (B.  cereus, B. thuringiensis and B. anthracis). The solved structure of B. anthracis homologs has a variant of the Greek-key beta barrel fold, making the DUF4870 family a member of a large group of bacterial immunoglobulin like domains, but the functional consequences of this classification remain unknown.