SII-SWORD/CoKE huggingface dataset:
Pfam PF15082: Domain of unknown function (DUF4549) (family)
This family of proteins is found in eukaryotes. Proteins in this family are typically between 143 and 1871 amino acids in length. The human member of this family is C6orf183.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF23584: Domain of unknown function (DUF7136) (domain)
This domain is found in a group of uncharacterised proteins mainly from Fungi. It is predicted to fold into a beta-sandwich with Ig-like topology.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF14660: Domain of unknown function (DUF4458) (domain)
this domain is found in tandem repeats on the N-terminus of secreted LRR proteins from human associated Bacteroidetes domain boundaries are based on the JCSG solved 3D structure of JCSG target SP16667A (BT_0210)
Pfam PF16410: Domain of unknown function (DUF5018) (family)
This family of proteins is functionally uncharacterised. This family is found in various Bacteroides and Alistipes species. Proteins in this family are around 600 amino acids in length.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF09407: AbiEi antitoxin C-terminal domain (domain)
AbiEi_1 is the cognate antitoxin of the type IV toxin-antitoxin 'innate immunity' bacterial abortive infection (Abi) system that protects bacteria from the spread of a phage infection. The Abi system is activated upon infection with phage to abort the cell thus preventing the spread of phage through viral replication. There are some 20 or more Abis, and they are predominantly plasmid-encoded lactococcal systems. TA, toxin-antitoxin, systems on plasmids function by killing cells that lose the plasmid upon division. AbiE phage resistance systems function as novel Type IV TAs and are widespread in bacteria and archaea. The cognate antitoxin is [pfam:PF13338].
Pfam PF00751: DM DNA binding domain (family)
The DM domain is named after dsx and mab-3. dsx contains a single amino-terminal DM domain, whereas mab-3 contains two amino-terminal domains.  The DM domain has a pattern of conserved zinc chelating residues C2H2C4. The dsx DM domain has been shown to dimerise and bind palindromic DNA.
Wikipedia: In molecular biology the DM domain is a protein domain first discovered in the doublesex proteins of Drosophila melanogaster and is also seen in C. elegans and mammalian proteins. In D. melanogaster the doublesex gene controls somatic sexual differentiation by producing alternatively spliced mRNAs encoding related sex-specific polypeptides. These proteins are believed to function as transcription factors on downstream sex-determination genes, especially on neuroblast differentiation and yolk protein genes transcription.
Pfam PF02561: Flagellar protein FliS (family)
FliS is coded for by the FliD operon and is transcribed in conjunction with FliD and FliT, however this protein has no known function.
Pfam PF23217: Domain of unknown function (DUF7066) (domain)
This is a beta-beta-alpha zinc finger found in a group of uncharacterised sequences, mainly from fungi.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF21814: Domain of unknown function (DUF6883) (domain)
This entry represents a protein domain that is often found in single domain proteins. It is also sometimes found in larger multi-domain proteins. The function of this domain is unknown.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF00690: Cation transporter/ATPase, N-terminus (domain)
Members of this families are involved in Na+/K+, H+/K+, Ca++ and Mg++ transport.
Wikipedia: The P-type ATPases, also known as E1-E2 ATPases, are a large group of evolutionarily related ion and lipid pumps that are found in bacteria, archaea, and eukaryotes. P-type ATPases are α-helical bundle primary transporters named based upon their ability to catalyze auto- (or self-) phosphorylation (hence P) of a key conserved aspartate residue within the pump and their energy source, adenosine triphosphate (ATP). In addition, they all appear to interconvert between at least two different conformations, denoted by E1 and E2. P-type ATPases fall under the P-type ATPase (P-ATPase) Superfamily (TC# 3.A.3) which, as of early 2016, includes 20 different protein families.
Pfam PF17201: Cache 3/Cache 2 fusion domain (domain)
The Cache_3-Cache_2 domain likely originated as a fusion of sCache_3 and sCache_2 domains.
Wikipedia: In molecular biology, the cache domain is an extracellular protein domain that is predicted to have a role in small-molecule recognition in a wide range of proteins, including the animal dihydropyridine-sensitive voltage-gated Ca2+ channel alpha-2delta subunit, and various bacterial chemotaxis receptors. The name Cache comes from CAlcium channels and CHEmotaxis receptors. This domain consists of an N-terminal part with three predicted strands and an alpha-helix, and a C-terminal part with a strand dyad followed by a relatively unstructured region. The N-terminal portion of the (unpermuted) Cache domain contains three predicted strands that could form a sheet analogous to that present in the core of the PAS domain structure. Cache domains are particularly widespread in bacteria such as Vibrio cholerae. The animal calcium channel alpha-2delta subunits might have acquired a part of their extracellular domains from a bacterial source. The Cache domain appears to have arisen from the GAF-PAS fold despite their divergent functions.
Pfam PF10096: Uncharacterized protein conserved in bacteria (DUF2334) (family)
This domain, found in various hypothetical bacterial proteins, has no known function.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF09756: DDRGK domain (family)
This is a family of proteins of approximately 300 residues, found in plants and vertebrates. They contain a highly conserved DDRGK motif.
Pfam PF18372: Integrin beta epidermal growth factor like domain 1 (domain)
This is the I-EGF 1 domain found in several integrin betas such as integrin beta 1-7. Structural analysis reveal an epidermal growth factor-like (I-EGF) domains 1 and 2. EGF1 lacks one disulfide (C2-C4) relative to the integrin EGF 2, 3, and 4 domains, this allows the C-terminal end of EGF1 to flex remarkably relative to its N-terminal end.
Pfam PF00475: Imidazoleglycerol-phosphate dehydratase (family)
Imidazoleglycerol-phosphate dehydratase (IGPD; 4.2.1.19) catalyzes the dehydration of imidazole glycerol phosphate to imidazole acetol phosphate, the sixth step of histidine biosynthesis in plants and microorganisms where the histidine is synthesized de novo. There is an internal repeat in the protein domain that is related by pseudo-dyad symmetry, perhaps as a result of an ancient gene duplication. The apo-form of IGPD exists as a catalytically inactive trimer which, in the presence of specific divalent metal cations such as manganese (Mn2+), cobalt (Co2+), cadmium (Cd2+), nickel (Ni2+), iron (Fe2+) and zinc (Zn2+), assembles to form a biologically active high molecular weight metalloenzyme; a 24-mer with 4-3-2 symmetry. Each 24-mer has 24 active sites, and contains around 1.5 metal ions per monomer, each monomer contributing residues to three separate active sites.

IGPD enzymes are monofunctional in fungi, plants, archaea and some eubacteria while they are encoded as bifunctional enzymes in other eubacteria, such that the enzyme is fused to histidinol-phosphate phosphatase, the penultimate enzyme of the histidine biosynthesis pathway. The histidine biosynthesis pathway is a potential target for development of herbicides, and IGPD is a target for the triazole phosphonate herbicides .
Wikipedia: The enzyme imidazoleglycerol-phosphate dehydratase (EC 4.2.1.19) catalyzes the chemical reactionD-erythro-1-(imidazol-4-yl)glycerol 3-phosphate  3-(imidazol-4-yl)-2-oxopropyl phosphate + H2O
Pfam PF06234: Toluene-4-monooxygenase system protein B (TmoB) (domain)
This family consists of several Toluene-4-monooxygenase system protein B (TmoB) sequences. Pseudomonas mendocina KR1 metabolises toluene as a carbon source. The initial step of the pathway is hydroxylation of toluene to form p-cresol by a multicomponent toluene-4-monooxygenase (T4MO) system. TmoB adopts a ubiquitin fold. Although TmoB is a component of the T4MO system, its  precise role remains unclear.
Pfam PF08145: BOP1NT (NUC169) domain (domain)
This N terminal domain is found in BOP1-like WD40 proteins.
Wikipedia: Ribosome biogenesis protein BOP1 is a protein that in humans is encoded by the BOP1 gene. It is a WD40 repeat-containing nucleolar protein involved in rRNA processing, thereby controlling the cell cycle. It is required for the maturation of the 25S and 5.8S ribosomal RNAs. It may serve as an essential factor in ribosome formation that coordinates processing of the spacer regions in pre-rRNA.
Pfam PF08813: Phage tail tube protein, TTP (family)
This is a family of phage tail tube proteins. A few members have an associated bacterial Ig-like domain, [pfam:PF02368], at their C-terminus.
Pfam PF01861: Branched-chain polyamine synthase A C-terminal domain (domain)
This domain is found in the C terminus of N(4)-bis(aminopropyl)spermidine synthase ([ec:2.5.1.128], also known as Branched-chain polyamine synthase A, BpsA) from hyperthermophiles and in uncharacterised proteins from bacteria and archaea.
Pfam PF06967: Mo-dependent nitrogenase C-terminus (family)
This family represents the C-terminus (approximately 80 residues) of a number of bacterial Mo-dependent nitrogenases. These are involved in nitrogen fixation in cyanobacteria. Note that many family members are hypothetical proteins.
Pfam PF21578: Virus, 117-like (family)
This protein family represents a group of viral proteins, including [swissprot:Q8QL45] from  Sulfolobus islandicus rod-shaped virus 1 (117).
Pfam PF15458: Nineteen complex-related protein 2 (family)
Family members include the NTR2 or Nineteen complex-related protein 2 found in fungus and plants. NTR2 proteins form a complex with the DExD/H-box RNA helicase Prp43. Along with NTR1 it is an accessory factor of Prp43 in catalysing spliceosome disassembly. Disassembly of the spliceosome after completion of the splicing reaction is necessary for recycling of splicing factors to promote efficient splicing. NTR2 and NTR1 associate with a post-splicing complex containing the excised intron and the spliceosomal U2, U5, and U6 snRNAs, that supports a link with a late stage in the pre-mRNA splicing process.
Pfam PF19011: Family of unknown function (DUF5740) (family)
This family is found in various Platyhelminthes, with many of the sequences annotated as being part of death domain-containing proteins. This highly conserved domain is located at the amino terminus. The function of this family is currently unknown.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF04366: Las17-binding protein actin regulator (family)
Ysc84 is a family of Las17-binding proteins found in metazoa. Together, Las17 and Ysc84 are essential for proper polymerisation of actin; Ysc84 is able to bind to and stabilise the actin dimer presented by Las17 and thereby promote polymerisation. An active actin cytoskeleton is necessary for adequate endocytosis.  ([pfam:PF00018]), or a FYVE zinc finger ([pfam:PF01363]).
Pfam PF08900: Transcriptional regulator AcaB (family)
This family of proteins is found in the IncC family of broad-host-range plasmids which enables the spread of antibiotic resistance genes among human enteric pathogens. Recently, AcaB member has been characterised as a transcriptional regulator that plays a crucial role in the regulation of IncC conjugation. It is a DNA binding protein which binds upstream of the acaDB promoter to increase its transcription and, in turn, acaDB activates the transcription of IncC conjugation genes. Structurally, AcaB consists of two helical hairpins in tandem which assemble into an anti-parallel four-helix bundle to form a two-stranded antiparallel beta-sheet positioned parallel to the helices. This is structurally similar to bacterial transcription factors from the ribbon-helix-helix (RHH) superfamily.
Pfam PF04346: Ethanolamine utilisation protein, EutH (family)
EutH is a bacterial membrane protein whose molecular function is unknown. It has been suggested that it may act as an ethanolamine transporter, responsible for carrying ethanolamine from the periplasm to the cytoplasm.
Pfam PF20903: Spore photoproduct lyase (family)
Bacterial spores are remarkable in their resistance to chemical and physical stresses, including exposure to UV radiation. The unusual UV resistance of bacterial spores is a result of the unique photochemistry of spore DNA coupled with the efficient repair of accumulated damage. Exposure of bacterial spores to UV radiation results in the formation of a methylene-bridged thymine dimer, 5-thyminyl-5,6-dihydrothymine, a spore photoproduct, or SP, as the primary photoproduct. SP accumulates in UV-irradiated spores, however it is rapidly repaired upon germination, thus giving rise to the extraordinary UV resistance of bacterial spores. The repair of SP is catalyzed by the enzyme spore photoproduct lyase (SPL), and involves the direct reversal of SP to two thymines without base excision.
Pfam PF01503: Phosphoribosyl-ATP pyrophosphohydrolase (family)
This enzyme catalyses the second step in the histidine biosynthetic pathway.
Pfam PF11809: Domain of unknown function (DUF3330) (family)
This family of proteins are functionally uncharacterised. This family is only found in bacteria.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF11192: Protein of unknown function (DUF2977) (family)
This family of proteins has no known function.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF06043: Reovirus P9-like family (family)
These proteins of unknown function are found in Rice black streaked dwarf virus (RBSDV) and other viruses.
Pfam PF15669: Coiled-coil domain-containing protein 24 family (family)
This family of proteins is found in eukaryotes. Proteins in this family are typically between 187 and 319 amino acids in length. There are two completely conserved residues (G and P) that may be functionally important.
Pfam PF24970: RUNKEL ARM-repeat domain (repeat)
This is the C-terminal domain of Serine/threonine-protein kinase RUNKEL from Arabidopsis thaliana and related plant sequences. It consists of ARM repeats. RUNKEL is an essential protein that regulates phragmoplast microtubule organization during cell plate expansion in cytokinesis during cell division, both somatic and syncytial.
Pfam PF19550: Family of unknown function (DUF6073) (family)
This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0001804) is described by MIBiG as an example of the following biosynthetic class, polyketide. This family includes a  protein from the tiancimycin biosynthetic gene cluster from  Streptomyces sp. CB03234 and appears to be predominantly found in bacteria.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF14073: Centrosome localisation domain of Cep57 (coiled_coil)
The CLD or centrosome localisation domain of Cep57 is found at the N-terminus, and lies approximately between residues 58 and 239. This region lies within the first alpha-helical coiled-coil segment of Cep57, and localises to the centrosome internally to gamma-tubulin, suggesting that it is either on both centrioles or on a centromatrix component.  This N-terminal region can also multimerise with the N-terminus of other Cep57 molecules.  The C-terminal part, Family Cep57_MT_bd, [pfam:PF06657], is the microtubule-binding region of Cep57.
Pfam PF18191: Hydroquinone 1,2-dioxygenase large subunit N-terminal (domain)
This is the N-terminal domain of the alpha subunit, known as PnpD, of Hydroquinone 1,2-dioxygenase (PnpCD) present in Pseudomonas sp. strain WBC-3. PnpCD is the key enzyme in the degradation pathway of pollutant para-nitrophenol (PNP). The N-terminal domain residues Trp-76 and Phe-79 are indispensable in the formation of the active site pocket. The N-terminal domain also plays a vital role in formation of the heterotetrameric structure. Structural homologs of the N-terminal domain exhibit the nature to bind nucleic acids but due to the steric effect of the C-terminal domain, this N-terminal domain cannot bind nucleic acids.
Pfam PF14366: Domain of unknown function (DUF4410) (family)
This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 187 and 238 amino acids in length.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF03848: Tellurite resistance protein TehB (family)
Tellurite resistance protein TehB is part of a tellurite-reducing operon tehA and tehB. When present in high copy number, TehB is responsible for potassium tellurite resistance, probably by increasing the reduction rate of tellurite to metallic tellurium within the bacterium. TehB is a cytoplasmic protein which possesses three conserved motifs (I, II, and III) found in S-adenosyl-L-methionine (SAM)-dependent non-nucleic acid methyltransferases . Conformational changes in TehB are observed upon binding of both tellurite and SAM, suggesting that TehB utilises a methyltransferase activity in the detoxification of tellurite.

This entry represents the methyltransferase domain found in all TehB proteins.
Pfam PF04410: Gar1/Naf1 RNA binding region (domain)
Gar1 is a small nucleolar RNP that is required for pre-mRNA processing and pseudouridylation. It is co-immunoprecipitated with the H/ACA families of snoRNAs. This family represents the conserved central region of Gar1. This region is necessary and sufficient for normal cell growth, and specifically binds two snoRNAs snR10 and snR30. This region is also necessary for nucleolar targeting, and it is thought that the protein is co-transported to the nucleolus as part of a nucleoprotein complex. In humans, Gar1 is also component of telomerase in vivo.  Naf1 is an essential protein that plays a role in ribosome biogenesis, modification of spliceosomal small nuclear RNAs and telomere synthesis, and is homologous to Gar1.
Pfam PF17702: Family of unknown function (DUF5548) (family)
This is a family of unknown function found in primates.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF10920: Protein of unknown function (DUF2705) (family)
This bacterial family of transmembrane proteins is related to ABC2 membrane transporter proteins.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.