SII-SWORD/CoKE huggingface dataset:
Pfam PF10830: Protein of unknown function (DUF2553) (family)
This family of bacterial proteins has no known function.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF18503: 26S proteasome subunit RPN6 C-terminal helix domain (domain)
This is the C-terminal helix domain found in RPN6, a component of the 26S proteasome. The C-terminal helices are essential for lid assembly.
Pfam PF03083: Sugar efflux transporter for intercellular exchange (repeat)
This family includes proteins such as drosophila saliva, MtN3 involved in root nodule development and a protein involved in activation and expression of recombination activation genes (RAGs). Although the molecular function of these proteins is unknown, they are almost certainly transmembrane proteins. This family contains a region of two transmembrane helices that is found in two copies in most members of the family. This family also contains specific sugar efflux transporters that are essential for the maintenance of animal blood glucose levels, plant nectar production, and plant seed and pollen development. In many organisims it meditaes gluose transport; in Arabidopsis it is necessary for pollen viability; and two of the rice homologues are specifically exploited by bacterial pathogens for virulence by means of direct binding of a bacterial effector to the SWEET promoter.
Wikipedia: The SWEET family, also known as the PQ-loop, Saliva or MtN3 family, is a family of sugar transporters and a member of the TOG superfamily. The proteins of the SWEET family have been found in plants, animals, protozoans, and bacteria. Eukaryotic family members have 7 transmembrane segments (TMSs) in a 3+1+3 repeat arrangement.
Pfam PF22377: TarS C-terminal domain 2 (domain)
This entry represents the C-terminal domain 2 (C2) of TarS from Staphylococcus aureus, the enzyme responsible for polyribitol phosphate beta-O-GlcNAcylation of wall teichoic acid polymers, a process that has been shown to be specifically responsible for methicillin resistance. This domain is involved in formation of extensive trimerization interface.
Pfam PF21508: MenC, N-terminal domain (domain)
MenC (o-succinylbenzoate synthase OSBS converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 2-succinylbenzoate (OSB). It belongs to the enolase superfamily. This entry represents the N-terminal domain of MenC.
Pfam PF11354: Protein of unknown function (DUF3156) (family)
This family of proteins with unknown function appears to be restricted to Proteobacteria.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF16022: Domain of unknown function (DUF4783) (domain)
This family of proteins is found in bacteria. Proteins in this family are approximately 130 amino acids in length. There is a single completely conserved residue F that may be functionally important. Recent structures show this domain has an NTF2 fold.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF22165: SSO1393-like, winged-helix domain (domain)
This entry represents a WH-like domain present in SSO1393-like proteins. SSO1393 is an archaeal protein from Sulfolobus solfataricus (PDB:3qyf). This protein has been described as a component of the CRISPR system. CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids).
Pfam PF07100: Anabaena sensory rhodopsin transducer (family)
The family of bacterial Anabaena sensory rhodopsin transducers are likely to bind sugars or related metabolites. The entire protein is comprised of a single globular domain with an eight-stranded beta-sandwich fold. There are a few characteristics which define this beta-sandwich fold as being distinct from other so-named folds, and these are: 1) a well conserved tryptophan, usually following a polar residue, present at the start of the first strand; this tryptophan appears to be central to a hydrophobic interaction required to hold the two beta-sheets of the sandwich together, and 2) a nearly absolutely conserved asparagine located at the end of the second beta-strand, that hydrogen bonds with the backbone carbonyls of the residues 2 and 4 positions downstream from it, thereby stabilising the characteristic tight turn between strands 2 and 3 of the structure.
Pfam PF14213: STAS-like domain of unknown function (DUF4325) (domain)
This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria, archaea, eukaryotes and viruses. Proteins in this family are typically between 99 and 341 amino acids in length. This domain is distantly related to the STAS domain.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF22951: Three-helical bundle domain (domain)
This domain is found in the YEATS domain-containing protein 2 (YEATS2) and related eukaryotic proteins. YEATS2 is a chromatin reader component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. YEATS2 specifically recognises and binds histone H3 crotonylated at 'Lys-27' (H3K27cr). The domain represented by this entry is predicted to adopt a globular structure consisting of a bundle of three alpha helices. This domain contains two semi-conserved sequence motifs: YX(5)GKRR and WCRXHGYTP. The function of this domain is unknown.
Pfam PF24425: Nuclear pore complex protein GP210, Ig-like domain (domain)
This domain is found in the Nuclear pore complex protein GP210 from Arabidopsis thaliana and related proteins. GP210 is predicted to contain 16 Ig-like domains. This entry represents the 15th of these domains.
Pfam PF07579: Domain of Unknown Function (DUF1548) (family)
This family appears to be found only in a small family of Chlamydia proteins.
Pfam PF01664: Reovirus viral attachment protein sigma 1 (family)
This family consists of the reovirus sigma 1 hemagglutinin, cell attachment protein. This glycoprotein is a minor capsid  protein and also determines the serotype-specific humoral immune response. Sigma 1 consist of a fibrous tail and a globular head. The head has important roles in the cell attachment function of sigma 1  and determinant of the type-specific humoral immune response. Reovirus is part of the orthoreovirus group of retroviruses with, a dsRNA genome. Also present in this family is bacteriophage SF6  Lysozyme [swissprot:P21270].
Pfam PF22882: GT-D fold-like domain (domain)
This domain is related to the GT-D fold glycosyltransferase domain ([pfam:PF08759]). These protein domains share a common sequence motif R[VIL]GDGE, significant structural similarity based on the predicted AF2 model, but low sequence similarity. This domain is found standalone and in combination with other domains in a number of proteins mainly from Firmicutes.
Pfam PF11973: NQRA C-terminal domain (domain)
This family consists of the C-terminal domain of several bacterial Na(+)-translocating NADH-quinone reductase subunit A (NQRA) proteins.  The Na(+)-translocating NADH: ubiquinone oxidoreductase (Na(+)-NQR) generates an electrochemical Na(+) potential driven by aerobic respiration.
Pfam PF09370: Phosphoenolpyruvate hydrolase-like (domain)
This domain has a TIM barrel fold related to IGPS and to phosphoenolpyruvate mutase/aldolase/carboxylase.
Pfam PF02613: Nitrate reductase delta subunit (family)
This family is the delta subunit of the nitrate reductase enzyme, The delta subunit is not part of the nitrate reductase enzyme but is most likely needed for assembly of the multi-subunit enzyme complex.  In the absence of the delta subunit the core alpha beta enzyme complex is unstable.  The delta subunit is essential for enzyme activity in vivo and in vitro.  The nitrate reductase enzyme, [ec:1.7.99.4] catalyse the conversion of nitrite to nitrate via the reduction of an acceptor.                  The nitrate reductase enzyme is composed of three subunits.         Nitrate is the most widely used alternative electron acceptor after oxygen. This family also now contains the family TorD, a family of cytoplasmic chaperone proteins; like many prokaryotic molybdoenzymes, the TMAO reductase (TorA) of Escherichia coli requires the insertion of a bis(molybdopterin guanine dinucleotide) molybdenum (bis(MGD)Mo) cofactor in its catalytic site to be active and translocated to the periplasm. The TorD chaperone increases apoTorA activation up to four-fold, allowing maturation of most of the apoprotein.   Therefore TorD is involved in the first step of TorA maturation to make it competent to receive the cofactor.
Wikipedia: Nitrate reductases are molybdoenzymes that reduce nitrate to nitrite. This reaction is critical for the production of protein in most crop plants, as nitrate is the predominant source of nitrogen in fertilized soils.
Pfam PF15755: Domain of unknown function (DUF4689) (family)
This family of proteins is found in eukaryotes. Proteins in this family are typically between 202 and 224 amino acids in length.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF04871: Uso1 / p115 like vesicle tethering protein, C terminal region (family)
Also known as General vesicular transport factor, Transcytosis associate protein (TAP) and Vesicle docking protein, this myosin-shaped molecule consists of an N-terminal globular head region, a coiled-coil tail which mediates dimerisation, and a short C-terminal acidic region.  p115  tethers COP1 vesicles to the Golgi by binding the coiled coil proteins giantin (on the vesicles) and GM130 (on the Golgi), via its C-terminal  acidic region.  It is required for intercisternal transport in the golgi stack. This family consists of the acidic C-terminus, which binds to the golgins giantin and GM130.  p115 is thought to juxtapose two membranes by binding giantin with one acidic region, and GM130 with another.
Pfam PF11633: Betacoronavirus single-stranded poly(A) binding domain (domain)
This domain identifies non-structural protein NSP3, the product of ORF1a in group 2 coronavirus. It is found in human SARS coronavirus polyprotein 1a and 1ab, and in related coronavirus polyproteins. NSP3 binds to viral RNA, nucleocapsid protein, as well as other viral proteins, and participates in polyprotein processing. The domain exhibits a macrodomain fold containing the nsp3 residues 528 to 648, with a flexibly extended N-terminal tail from residues 513 to 527 and a C-terminal flexible tail of residues 649 to 651. SUD-M(527-651) binds single-stranded poly(A); the contact area with this RNA on the protein surface, and the electrophoretic mobility shift assays confirm that SUD-M has higher affinity for purine bases than for pyrimidine bases.
Pfam PF24044: Domain of unknown function (DUF7353) (domain)
This domain is found in a group of uncharacterised proteins from Kinetoplastida. It is found on its own or in combination with [[pfam:PF00650]]. It is predicted adopt a UBA-like alpha-helical bundle.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF12072: RNase Y N-terminal region (coiled_coil)
This domain is found at the N terminus of ribonuclease Y. RNase Y from Bacillus subtilis is the functional equivalent of RNase E from Escherichia coli, even though the two enzymes do not share any sequence similarity. It is involved in the initiation of RNA degradation, interacting with other proteins in a degradosome-like complex . In contrast to B. subtilis, the RNase Y homologue (rny/cvfA) of Staphylococcus aureus is not essential for growth, but plays a major role in virulence gene regulation .

RNase Y has two central KH and HD domains . A coiled-coil domain with the potential to form a leucine zipper has been proposed for residues 30 to 150 at the N terminus .
Pfam PF07346: Protein of unknown function (DUF1477) (family)
This family consists of several hypothetical Nucleopolyhedrovirus proteins of around 100 resides in length. The function of this family is unknown.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF14611: SLS1 protein first KH domain (domain)
This entry represents the first of two KH domains found in the SLS1 protein.  SLS1 is a fungal protein found bound to the mitochondrial inner-membrane. It reacts physically with fungal Kar2p to promote translocation across the endoplasmic-reticulum membrane. This action appeared to be mediated via the promotion of the Sec63p-mediated activation of Kar2p's ATPase activity. This indicates that the Sls1p protein is a GrpE-like protein in the endoplasmic reticulum. In S.cerevisiae the SLS1 gene (ScSLS1) is not essential but is also involved in ERAD and folding.
Pfam PF11672: zinc-finger-containing domain (family)
This is a family of bacterial and plasmid sequences that carry at least one zinc-finger towards the N-terminus and a possible second at the C-terminus.
Pfam PF14615: Ribosome-assembly protein 3 (family)
This is a family of 60S ribosome-assembly proteins, from fungi.
Pfam PF07584: Aerotolerance regulator N-terminal (domain)
These proteins share a highly-conserved sequence at their N-terminus.  They include several proteins from Rhodopirellula baltica and also several from proteobacteria. The proteins are produced by the Batl operon which appears to be important in pathogenicity and aerotolerance. This family is the conserved N-terminus, but the full length proteins carry multiple membrane-spanning domains. BatA ensures bacterial survival in the early stages of the infection process, when the infected sites are aerobic, and is produced under conditions of oxidative stress.
Pfam PF18737: MAE_28990/MAE_18760-like HEPN (domain)
HEPN-like nuclease. MAE_28990 In operon with a ParB nuclease and DNA methylase genes. MAE_18760-like HEPN found fused to HEPN/RES-NTD1, HEPN/Toprim-NTD1, Schlafen and a novel beta rich domain. In operon with ParA/Soj ATPase of SIMIBI-type GTPase fold.
Pfam PF25113: Separase-like, TPR repeats (repeat)
This region of tetratricopeptide (TPR)-like repeats is found in Separase from Arabidopsis thaliana (ESP1) and similar plant proteins. ESP1 is essential for embryo and endosperm development and may play a role in centromeric heterochromatin structure /formation during early meiosis, non-homologous centromere association and radial microtubule system.
Pfam PF02533: Photosystem II 4 kDa reaction centre component (family)
This family consists of various photosystem II 4 kDa reaction centre components (PsbK) from plant and Cyanobacteria.  The photosystem II reaction centre is responsible for catalysing the core photosynthesis reaction the light-induced splitting of water and the consequential release of dioxygen.  In C. reinhardtii the psbK product is required for the stable assembly and/or stability of the photosystem II complex.
Pfam PF16976: Flp pilus assembly protein RcpC/CpaB (family)
RcpC is a family of Gram-negative proteins expressed from the tight-adherence tad locus. RcpC is an auxillary protein that sits in the inner membrane and interacts with TadB and TadZ, an AAA ATPase. A recent study has identified two tandem beta-clip domains in RcpC95. beta-Clip domains are known to interact with carbohydrate moieties in other systems, such as SAF.
Pfam PF07562: Nine Cysteines Domain of family 3 GPCR (family)
This conserved sequence contains several highly-conserved Cys residues that are predicted to form disulphide bridges. It is predicted to lie outside the cell membrane, tethered to the [pfam:PF00003] in several receptor proteins.
Pfam PF18908: Protein of unknown function (DUF5663) (family)
This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 102 and 113 amino acids in length.
Pfam PF19866: Family of unknown function (DUF6339) (family)
This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 247 and 267 amino acids in length.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF20861: Iron-regulated surface determinant protein H/B, linker domain (domain)
The bacterial pathogen Staphylococcus aureus uses two closely related receptors located on its surface, IsdH and IsdB, to capture from haemoglobin (Hb) the iron it needs to grow. Both proteins show conserved near iron transporter (NEAT) domains ([pfam:PF05031]) that function synergistically. These domains, essential for the arrest of iron, are appropriately positioned by an alpha-helical linker domain (this entry), which does not interact itself with the heme group. In IsdH, this linker domain forms a three-helix bundle structure that is essential for efficient heme capture.
Pfam PF23502: YdgV (family)
This protein family includes Protein YdgV from Escherichia coli and similar sequences from gammaproteobacteria. YdgV is a 33-residues micropeptide encoded by a small open reading frame (smORF). Proteins 50 or fewer residues-long have been shown to regulate the functions of larger proteins in a variety of organisms.
Pfam PF12907: Zinc-binding (family)
This is small family of metazoan zinc-binding proteins.
Pfam PF10756: Bacterial PH domain (domain)
This domain has a bacterial type PH domain structure. This domain was previously known as DUF2581. This family is conserved in the Actinomycetales.  Although several members are annotated as RbiX homologues, RbiX being a putative regulator of riboflavin biosynthesis, the function could not be confirmed.
Pfam PF07995: Glucose / Sorbosone dehydrogenase (repeat)
Members of this family are glucose/sorbosone dehydrogenases that possess a beta-propeller fold.
Pfam PF00585: C-terminal regulatory domain of Threonine dehydratase (domain)
Threonine dehydratases [pfam:PF00291] all contain a carboxy terminal region.  This region may have a regulatory role. Some members contain two copies of this region. This family is homologous to the [pfam:PF01842] domain.
Pfam PF11902: Protein of unknown function (DUF3422) (family)
This family of proteins are functionally uncharacterised. This protein is found in bacteria, archaea and eukaryotes. Proteins in this family are typically between 426 to 444 amino acids in length.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF17140: Domain of unknown function (DUF5113) (repeat)
This domain is frequently found downstream of family HATPase_c [pfam:PF00025]1 in duplicate.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF01844: HNH endonuclease (family)
His-Asn-His (HNH) proteins are a very common family of small nucleic acid-binding proteins that are generally associated with endonuclease activity.
Wikipedia: The homing endonucleases are a collection of endonucleases encoded either as freestanding genes within introns, as fusions with host proteins, or as self-splicing inteins. They catalyze the hydrolysis of genomic DNA within the cells that synthesize them, but do so at very few, or even singular, locations. Repair of the hydrolyzed DNA by the host cell frequently results in the gene encoding the homing endonuclease having been copied into the cleavage site, hence the term 'homing' to describe the movement of these genes. Homing endonucleases can thereby transmit their genes horizontally within a host population, increasing their allele frequency at greater than Mendelian rates.
Pfam PF22656: Glyoxalase At5g48480-like, N-terminal domain (domain)
This entry includes, mainly, plant sequences that belong to the Lactoylglutathione lyase/glyoxalase I family. They are poorly characterised and contain two characteristic VOC domains. Members of this entry contain conserved metal binding amino acids with the type I extradiol dioxygenases, which shows no domain swapping. This entry represents the N-terminal domain.