SII-SWORD/CoKE huggingface dataset:
Pfam PF19696: Family of unknown function (DUF6196) (family)
This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0001381) is described by MIBiG as an example of the following biosynthetic class, polyketide. It includes a member from  the brasilinolide A biosynthetic gene cluster from Nocardia  terpenica. This family appears to be predominantly found in  bacteria.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF10412: Type IV secretion-system coupling protein DNA-binding domain (domain)
The plasmid conjugative coupling protein TrwB forms hexamers from six structurally very similar protomers. This hexamer contains a central channel running from the cytosolic pole (made up by the AADs) to the membrane pole ending at the transmembrane pore shaped by 12 transmembrane helices, rendering an overall mushroom-like structure. The TrwB_AAD (all-alpha domain) domain appears to be the DNA-binding domain of the structure. TrwB, a basic integral inner-membrane nucleoside-triphosphate-binding protein, is the structural prototype for the type IV secretion system coupling proteins, a family of proteins essential for macromolecular transport between cells and export.
Pfam PF05054: Autographa californica nuclear polyhedrosis virus (AcMNPV) protein (family)
This domain family is found in viral proteins such as Ac109 from Autographa californica nuclear polyhedrosis virus (AcMNPV). The gene (Orf1090) is essential and transcribed late in virus assembly, and protein AC109 has been shown to be important for the transport of the budded virion to the host nucleus. In mutants lacking the AC109 gene, virions are unable to enter the nucleus and remain in the cytoplasm. Although addition of AC109 allowed virions to enter the nucleus, the occlusion bodies were empty, indicating that AC109 is also important for the production of infectious budded virus. The exact function of this domain family remains unknown.
Pfam PF03561: Allantoicase repeat (family)
This family is found in pairs in Allantoicases, forming the majority of the protein. These  proteins allow the use of purines as secondary nitrogen sources in nitrogen-limiting conditions through the reaction: allantoate + H(2)0 = (-)-ureidoglycolate + urea.
Wikipedia: Allantoicase is an enzyme (EC 3.5.3.4) that in humans is encoded by the ALLC gene. Allantoicase catalyzes the chemical reactionallantoate + H2O  (S)-ureidoglycolate + urea
Pfam PF03386: Early nodulin 93 ENOD93 protein (family)
The expression of early nodulin (ENOD) genes has been well characterised in several legume species. Based on their biochemical attributes and expression patterns, they are postulated to have roles in cell structure, in the control of nodule ontogeny by the degradation of Nod factor, and in carbon metabolism .
Pfam PF21409: Ski2, beta-barrel domain (domain)
Ski2 from yeast is an helicase with an overall similar structure to MTR4 proteins. It has an arch domain with an helical stalk/elbow ([pfam:PF21408]) that flanks a beta-barrel (referred to as the KOW module in MTR4 homologues). This entry represents the beta-barrel of Ski2 which does not have the KOW motif and is tightly packed against the helical stalk.
Pfam PF15715: PCNA-associated factor histone like domain (domain)
This domain corresponds to a histone like fold in p15(PAF).
Wikipedia: PCNA-associated factor is a protein that in humans is encoded by the KIAA0101 gene.
Pfam PF24646: Domain of unknown function (DUF7640) (repeat)
This is a presumed domain found in a group of uncharacterised sequences from diatoms. This domain may adopt a beta-solenoid fold and in some members is repeated twice or three times.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF06220: U1 zinc finger (domain)
This family consists of several U1 small nuclear ribonucleoprotein C (U1-C) proteins. The U1 small nuclear ribonucleoprotein (U1 snRNP) binds to the pre-mRNA 5' splice site (ss) at early stages of spliceosome assembly.  Recruitment of U1 to a class of weak 5' ss is promoted by binding of the protein TIA-1 to uridine-rich sequences immediately downstream from the 5' ss. Binding of TIA-1 in the vicinity of a 5' ss helps to stabilise U1 snRNP recruitment, at least in part, via a direct interaction with U1-C, thus providing one molecular mechanism for the function of this splicing regulator. This domain is probably a zinc-binding.  It is found in multiple copies in some members of the family.
Pfam PF22181: Glycosyl transferase TarS linker domain (domain)
TarS is an enzyme responsible for the glycosylation of wall teichoic acid polymers of the S. aureus cell wall, a process that has been shown to contribute for methicillin resistance in MRSA. TarS consist of three domains: catalytic, linker and trimerisation. This entry represents the linker domain that bridges the catalytic and trimerisation domains.
Pfam PF16422: Transcription factor COE1 DNA-binding domain (domain)
This entry represents the DNA-binding domain of COE1, COE2, COE3 and COE4 (also known as Ebf1, Ebf2, Ebf3 and Ebf4), they belong to the early B cell factor family. COE1 is a key transcriptional determinant of B-lymphocyte differentiation . COE3 is a transcription factor involved in neuronal differentiation and maturation .
Wikipedia: Transcription factor COE1 is a protein that in humans is encoded by the EBF1 gene. 
EBF1 stands for Early B-Cell Factor 1.
Pfam PF03752: Short repeats of unknown function (repeat)
This set of repeats is found in a small family of secreted proteins of no known function, though they are possibly involved in signal transduction. ALF stands for Alanine-rich (AL) - conserved Phenylalanine (F).
Pfam PF24313: Paratox (family)
This entry represents the conserved mosaic prophage protein Paratox and related proteins. Paratox inhibits the natural competence regulator ComR and serves as a repressor of the competence regulon in vivo. This protein folds into an alpha/beta structure consisting of a three-stranded beta-sheet and two alpha-helices packed on one side of the sheet.
Pfam PF19486: Family of unknown function (DUF6022) (family)
This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0000693) is described by MIBiG as an example of the following biosynthetic class, saccharide. This family includes a  protein from the butirosin A biosynthetic gene cluster from Bacillus  circulans and appears to be predominantly found in Bacilli.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF02836: Glycosyl hydrolases family 2, TIM barrel domain (domain)
This family contains beta-galactosidase, beta-mannosidase and beta-glucuronidase activities.
Wikipedia: In molecular biology, Glycoside hydrolase family 2 is a family of glycoside hydrolases EC 3.2.1., which are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycoside hydrolases, based on sequence similarity, has led to the definition of &gt;100 different families. This classification is available on the CAZy web site, and also discussed at CAZypedia, an online encyclopedia of carbohydrate active enzymes.
Pfam PF15695: Rec (regulator of expression encoded by corf) of HERV-K-113 (family)
REC is a family of rec proteins from the HERV-K viral polyprotein family. Rec is a functional homologue of Rev and Rex, and binds to an RNA element, the Rec-responsive element (RcRE), in the 3'LTR of HTDV/HERV-K transcripts. Thus Rec mediates nuclear export of RNA by binding to its responsive element, RcRE, present in a transcript. The human small glutamine-rich tetratricopeptide repeat-containing protein (hSGT) that controls mitotic processes and is a checkpoint protein during pro-metaphase is found to be a Rec-interacting partner.interferes with its role as a negative regulator of the androgen receptor, leading to enhanced androgen receptor activity. HERV-K(HML-2) elements benefit from this enhanced activity, as this leads to a vicious cycle that can result in increased cell proliferation, an inhibition of apoptosis, and eventually tumourigenesis.
Pfam PF18551: Thaumarchaeal output domain 1 (domain)
TackOD1 (Thaumarchaeal output domain 1) is a predicted metal-binding domain found in archaea and in some bacteria. It contains 11 highly conserved Cys residues, which form 5 CxxC motifs and an HxxC motif. In several instances, it is found in combination with the Response_reg [pfam:PF00072] domain (Galperin et al., 2018, Phyletic distribution and lineage-specific domain architectures of archaeal two-component signal transduction systems).
Pfam PF20959: BibA adhesin stalk domain (domain)
BibA, a group B streptococcus (GBS) surface protein, has been shown to protect the pathogen from phagocytic killing by sequestering a complement inhibitor: C4b-binding  protein (C4BP). This entry represents a three helical repeated domain in this protein.
Pfam PF21122: BRSK1/2 KA1 domain (domain)
This entry represents the KA1-like domain found in the brain-specific kinases BRSK1 and BRSK2. The BRSK/SAD kinase family includes serine/threonine-protein kinases that play crucial roles in neuronal polarization, centrosome duplication, cell cycle progression, and insulin secretion. Members phosphorylate a variety of substrates including CDC25B, CDC25C, MAPT/TAU, and WEE1, modulating their activities. Activation by STK11/LKB1 is a common regulatory mechanism, leading to phosphorylation of microtubule-associated proteins and influencing neuron polarization. These kinases also contribute to synaptic vesicle function and neurotransmitter release, regulate the mitotic cell cycle, and respond to DNA damage. Additionally, they are involved in actin cytoskeleton reorganization and may play a role in the apoptotic response to endoplasmic reticulum stress.
Pfam PF01993: methylene-5,6,7,8-tetrahydromethanopterin dehydrogenase (family)
This enzyme family is involved in formation of methane from carbon dioxide [ec:1.5.99.9]. The enzyme requires coenzyme F420.
Pfam PF15428: Immunity protein 26 (family)
A predicted immunity protein with mostly all-beta fold and several conserved hydrophobic residues. Proteins containing this domain are present in bacterial polymorphic toxin systems as an immediate gene neighbour of the toxin gene, usually containing a domain of the Tox-URI1 or Tox-HNH family. The protein is also found heterogeneous poly-immunity loci.
Pfam PF05784: Betaherpesvirus UL82/83 protein N terminus (family)
This family represents the N terminal region of the Betaherpesvirus UL82 and UL83 proteins. As viruses are reliant upon their host cell to serve as proper environments for their replication, many have evolved mechanisms to alter intracellular conditions to suit their own needs. Human cytomegalovirus induces quiescent cells to enter the cell cycle and then arrests them in late G(1), before they enter the S phase, a cell cycle compartment that is presumably favourable for viral replication. The protein product of the human cytomegalovirus UL82 gene, pp71, can accelerate the movement of cells through the G(1) phase of the cell cycle. This activity would help infected cells reach the late G(1) arrest point sooner and thus may stimulate the infectious cycle. pp71 also induces DNA synthesis in quiescent cells, but a pp71 mutant protein that is unable to induce quiescent cells to enter the cell cycle still retains the ability to accelerate the G(1) phase. Thus, the mechanism through which pp71 accelerates G(1) cell cycle progression appears to be distinct from the one that it employs to induce quiescent cells to exit G(0) and subsequently enter the S phase.
Pfam PF23617: EF-hand (domain)
This domain is found in a group of fungal proteins that are likely possessing phosphoinositide phospholipase C activity. This domain shares significant similarity to EF-hand domains and it is predicted to adopt similar structure.
Pfam PF12670: Protein of unknown function (DUF3792) (family)
This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 130 amino acids in length. These proteins are integral membrane proteins.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF16699: Cleavage stimulation factor subunit 1, dimerisation domain (domain)
This family is the dimerisation domain, at the N-terminal, of a family of cleavage stimulation factor subunit 1 proteins from eukaryotes. This domain allows for homodimerisation such that the functional state of CSTF1 is a heterohexamer. The cleavage stimulation factor (CstF) complex is composed of three subunits and is essential for pre-mRNA 3'-end processing.  CstF recognises U and G/U-rich cis-acting RNA sequence elements and helps to stabilise the cleavage and polyadenylation specificity factor (CPSF) at the polyadenylation site as required for productive RNA cleavage.
Pfam PF13846: Domain of unknown function (DUF4196) (domain)
This is a short region of ccdc82_homologues that is conserved from Schizo. pombe up to humans.  The function is not known.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF10669: Protein gp23 (Bacteriophage A118) (family)
This is the highly conserved family of the major tail subunit protein.
Pfam PF22850: CATSPERD/E C-terminal domain (domain)
The CATSPER (cation channel of sperm) complex is a tetrameric complex consisting of CATSPER1, CATSPER2, CATSPER3 and CATSPER4, it functions as an alkalinisation-activated calcium channel. This complex is involved in sperm cell hyperactivation, a process needed for sperm motility, which is essential late in the preparation of sperm for fertilisation. This complex requires four auxiliary subunits (beta, gamma, delta and epsilon), which play a role in channel assembly. These are multidomain proteins which share a similar domain organisation. This entry represents the C-terminal domain of delta and epsilon subunits, which covers the stem domain and the transmembrane helix, which are involved in the association with the channel domain.
Pfam PF07876: Stress responsive A/B Barrel Domain (domain)
The function of this family is unknown, but it is upregulated in response to salt stress in Populus balsamifera (). It is also found at the C-terminus of an fructose 1,6-bisphosphate aldolase from Hydrogenophilus thermoluteolus ([swissprot:Q9ZA13];). [swissprot:Q93NG5] is found in the pA01 plasmid, which encodes genes for molybdopterin uptake and degradation of plant alkaloid nicotine. The structure of one has been solved ([swissprot:Q9LUV2]) and the domain forms an a/b barrel dimer (). Although there is a clear duplication within the domain it is not obviously detectable in the sequence.
Pfam PF10457: Cholesterol-capturing domain (domain)
Human meta-static lymph node (MLN) 64 is a late endosomal membrane protein, and carries this MENTAL (MLN64N-terminal) domain at its N-terminus. The domain is composed of four trans-membrane helices with three short intervening loops. The function of the domain is to capture cholesterol and pass it to the associated START domain [pfam:PF01852] for transfer to a cytosolic acceptor protein or membrane. In mammals, the MENTAL domain is involved in the localisation of MLN64 and MENTHO in late endosomes, and also in homo-and of hetero-interactions of these two proteins.
Wikipedia: The MENTAL or MLN64 NH2-terminal domain is a membrane-spanning domain that is conserved in two late endosomal proteins in vertebrates, MLN64 and MENTHO. The domain is 170 amino acids long.
Pfam PF24072: T7 virus internal virion protein gp14 family (family)
The T7 phage internal virion protein gp14 family is involved in the assembly of the cylindrical core on the inner surface of the viral capsid. This core, composed of stacked rings of gp14, gp15, and gp16 proteins, plays a crucial role in the ejection of viral DNA into the host cell. Upon binding to the host cell surface, the internal core disassembles, and gp14, along with gp15 and gp16, is ejected into the infected cell. The family may also form a simple channel spanning the outer membrane.
Pfam PF15628: RRM in Demeter (family)
This is a predicted RRM-fold domain present at the C-terminus of Demeter-like glycoslyases. These proteins  are involved in DNA demethylation in plants where they catalyze removal of the 5mC  base and subsequently cleave the backbone through lyase activity.  Orthologs of Demeter are present in plants and stramenopiles. The RRM fold domain is predicted to facilitate interaction of the catalytic  domain with ssDNA or regulatory RNA.
Pfam PF24955: DrmE-like N-terminal domain (domain)
This domain is found in DISARM protein DrmE related proteins from Halobacteria. It is predicted to adopt a globular structure composed of a central parallel beta-sheet and alpha-helices packed on both sides of it.
Pfam PF05996: Ferredoxin-dependent bilin reductase (family)
This family consists of several different but closely related proteins which include phycocyanobilin:ferredoxin oxidoreductase [ec:1.3.7.5] (PcyA), 15,16-dihydrobiliverdin:ferredoxin oxidoreductase [ec:1.3.7.2] (PebA) and phycoerythrobilin:ferredoxin oxidoreductase [ec:1.3.7.3] (PebB). Phytobilins are linear tetrapyrrole precursors of the light-harvesting prosthetic groups of the phytochrome photoreceptors of plants and the phycobiliprotein photosynthetic antennae of cyanobacteria, red algae, and cryptomonads. It is known that that phytobilins are synthesised from heme via the intermediary of biliverdin IX alpha (BV), which is reduced subsequently by ferredoxin-dependent bilin reductases with different double-bond specificities.
Pfam PF14723: Sperm-specific antigen 2 C-terminus (family)
This family includes the C-terminus of the actin-interacting protein sperm-specific antigen 2.
Pfam PF19176: Family of unknown function (DUF5858) (family)
This is a family of uncharacterised proteins of unknown function predominantly found in Marseillevirus.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF00909: Ammonium Transporter Family (family)
This ammonium transporter domain consists of a duplication of 2 structural repeats of five helices each plus one extra C-terminal helix. It has been described as a channel that spans the membrane 11 times .
Wikipedia: Ammonia transporters are structurally related membrane transport proteins called Amt proteins in bacteria and plants, methylammonium/ammonium permeases (MEPs) in yeast, or Rhesus (Rh) proteins in chordates. In humans, the RhAG, RhBG, and RhCG Rhesus proteins constitute solute carrier family 42 whilst RhD and RhCE form the Rh blood group system. The three-dimensional structure of the ammonia transport protein AmtB from Escherichia coli has been determined by x-ray crystallography revealing a hydrophobic ammonia channel. The human RhCG ammonia transporter was found to have a similar ammonia-conducting channel structure. It was proposed that the erythrocyte Rh complex is a heterotrimer of RhAG, RhD, and RhCE subunits in which RhD and RhCE might play roles in anchoring the ammonia-conducting RhAG subunit to the cytoskeleton. Based on reconstitution experiments, purified RhCG subunits alone can function to transport ammonia. RhCG is required for normal acid excretion by the mouse kidney and epididymis.
Pfam PF06855: YozE SAM-like fold (domain)
This entry represents a domain found in the YozE-like family. YozE-like is a family of Firmicute proteins that carries a four-helix motif similar to sterile alpha motif (SAM) domains. The family is suggested to fall into two subfamilies, possibly with differing functions based on the different surface charges on the three structural representatives, YozE MW0776 and MW1311. What this function is is not yet known although it is likely to involve binding to DNA.
Pfam PF22333: Argonaute, PAZ domain, archaea (domain)
This entry represents the PAZ domain of archaeal argonaute (Ago). Ago is a DNA-guided ssDNA endonuclease that may play a role in defense against invading genetic elements that uses short ssDNA sequences as guides (gDNA) to bind complementary target strands resulting in slicing of the target DNA (tDNA).
Pfam PF19054: Domain of unknown function (DUF5753) (domain)
This entry represents a putative ligand binding domain found in bacterial transcription regulators that have an N-terminal HTH domain [pfam:PF13560].
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF19022: Family of unknown function (DUF5748) (family)
The function of this family of euryarchaeal proteins is unknown.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.