SII-SWORD/CoKE huggingface dataset:
Pfam PF12056: Protein of unknown function (DUF3537) (family)
This family of transmembrane proteins are functionally uncharacterised. This protein is found in eukaryotes. Proteins in this family are typically between 427 to 453 amino acids in length.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF08828: Doublesex dimerisation domain (domain)
Doublesex (DSX) is a transcription factor that regulates somatic sexual differences in Drosophila.          The structure of this domain has revealed a novel dimeric arrangement of ubiquitin-associated folds that has not previously been identified in a transcription factor.
Pfam PF11193: Protein of unknown function (DUF2812) (family)
This is a bacterial family of uncharacterised proteins, however some members of this family are annotated as membrane proteins.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF02781: Glucose-6-phosphate dehydrogenase, C-terminal domain (domain)
Glucose-6-phosphate dehydrogenase (1.1.1.49) (G6PDH) is a ubiquitous protein, present in bacteria and all eukaryotic cell types . The enzyme catalyses the the first step in the pentose pathway, i.e. the conversion of glucose-6-phosphate to gluconolactone 6-phosphate in the presence of NADP, producing NADPH. The ubiquitous expression of the enzyme gives it a major role in the production of NADPH for the many NADPH-mediated reductive processes in all cells, and is critical for NADPH homeostasis and redox regulation . Deficiency of G6PDH is a common genetic abnormality affecting millions of people worldwide. Many sequence variants, most caused by single point mutations, are known, exhibiting a wide variety of phenotypes with the distinctive one being chronic and drug- or food-induced hemolytic anemia, attributed to the inability to produce NADPH and withstand harmful oxidants in erythrocyte cells .
This entry represents the C-terminal domain of glucose-6-phosphate dehydrogenase.
Wikipedia: Glucose-6-phosphate dehydrogenase (G6PD or G6PDH) (EC 1.1.1.49) is a cytosolic enzyme that catalyzes the chemical reactionD-glucose 6-phosphate + NADP+ + H2O ⇌ 6-phospho-D-glucono-1,5-lactone + NADPH + H+
Pfam PF08808: RES domain (domain)
This presumed domain contains 3 highly conserved polar groups that could form an active site. These are an arginine, glutamate and serine, hence the RES domain. The domain is found widely distributed in bacteria. The domain is about 150 residues in length.
Pfam PF18719: ArlS sensor domain (domain)
This entry represents the N-terminal extracellular sensor domain of the ArlS protein from S. aureus. It recognises LL-37 antimicrobial peptide (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).
Pfam PF12440: Melanoma associated antigen family N terminal (disordered)
This domain family is found in eukaryotes, and is typically between 82 and 96 amino acids in length. The family is found in association with [pfam:PF01454]. This family is the N terminal of various melanoma associated antigens. These are tumour rejection antigens which are expressed on HLA-A1 of tumour cells and they are recognised by cytotoxic T lymphocytes (CTLs).
Pfam PF16276: Nucleophosmin C-terminal domain (domain)
This domain, approximately 50 residues in length, is mainly found in Nucleophosmin proteins in mammalia species. Nucleophosmin, a nucleocytoplasmic shuttling protein, is related with cancer and involved in serveral cellluar functions, such as ribosome maturatation and export, centrosome duplication, and response to stress stimuli. This domain has a three-helix bundle which can bind G-quadruplex DNA and the interaction involves helices H1 and H2 of the NPM1-C domain mainly through electrostatic contacts with G-quadruplex phosphates, indicating a crucial role in rescuring its function in leukemia.
Pfam PF15348: Gemini of Cajal bodies-associated protein 8 (family)
GEMIN8 proteins are found in the nuclear bodies called gems (Gemini of Cajal bodies) that are often in proximity to Cajal (coiled) bodies themselves. They are also found in the cytoplasm. The family is part of the SMN (survival motor neurone) complex that plays an essential role in spliceosomal snRNP assembly in the cytoplasm and is required for pre-mRNA splicing in the nucleus. GEMIN8 binds directly to SMN1 and mediates the interaction of the GEMIN6-GEMIN7 heterodimer.
Pfam PF21303: Tetracyclin repressor-like, C-terminal domain (domain)
This domain is found at the C-terminal end of bacterial transcriptional regulators. It is normally found associated with [pfam:PF00440].
Pfam PF09877: Energy-converting hydrogenase subunit EhaL (family)
This family of archaeal proteins represents the Energy-converting hydrogenase subunit EhaL. Eha is the essential conduit of electrons from H2 and supports methanogenesis.
Pfam PF14666: Rapamycin-insensitive companion of mTOR, middle domain (domain)
Rictor appears to serve as a scaffolding protein that is important for maintaining mTORC2 integrity. The mammalian target of rapamycin (mTOR) is a conserved Ser/Thr kinase that forms two functionally distinct complexes, mTROC1 and mTORC2, important for nutrient and growth-factor signalling. This region is the more conserved central section that may include several individual domains. Rictor can be inhibited in the short-term by rapamycin.
Pfam PF09275: Pertussis toxin S4 subunit (domain)
Members of this family of Bordetella pertussis toxins adopt a structure consisting of an OB fold, with a closed or partly opened beta-barrel in a Greek-key topology.
Wikipedia: Pertussis toxin (PT) is a protein-based AB5-type exotoxin produced by the bacterium Bordetella pertussis, which causes whooping cough. PT is involved in the colonization of the respiratory tract and the establishment of infection. Research suggests PT may have a therapeutic role in treating a number of common human ailments, including hypertension, viral infection, and autoimmunity.
Pfam PF16144: Domain of unknown function (DUF4852) (family)
This family consists of several uncharacterized proteins around 350 residues in length and is mainly found in various Parabacteroides, Bacteroides and Porphyromonas species. The function of this family  is unknown.
Pfam PF24574: ACP-like domain (domain)
This domain, previously known as DUF7606, is found in Neisseria Adhesin Complex Protein (ACP) and in a group of uncharacterised sequences from proteobacteria. It folds into an eight-stranded beta-barrel, stabilised by a disulphide bond between the first and last beta-strands. Nm-ACP is structurally similar to members of the MliC/PliC protein family of lysozyme inhibitors. Despite it does not share any conserved MliC/PliC sequence motifs associated with lysozyme recognition, ACP is capable of inhibiting lysozyme.
Pfam PF05591: Type VI secretion system, VipA, VC_A0107 or Hcp2 (family)
T6SSs are toxin delivery systems. It is a multiprotein complex requiring numerous core proteins (Tss proteins) including cytoplasmic, transmembrane, and outer membrane components. The needle or tube apparatus is comprised of a phage-like complex, similar to the T4 contractile bacteriophage tail, which is thought to be anchored to the membrane by a trans-envelope complex. VipA is a family of Gram-negative bacterial proteins that form part of the type VI pathogenic secretion system. Members have been variously defined as VC_A0107 family, Hcp2, TssB and VipA, for ClpV-interacting proteins. VipB and VipA proteins interact very closely to form the shaft of the pathogenic penetrating needle system. VipA and VipB (TssB and TssC) proteins were shown to form a cog-wheel like tubular structure in V. cholerae that was noticed to resemble T4 phage gp18 polysheath. Two beta-strands of VipA and four beta-strands of VipB intertwine forming the middle layer of the sheath. The sheath assembles around an inner Hcp tube and is attached to a structure called a baseplate that spans the bacterial membranes. Importantly, VipA/VipB sheath was shown to form a long contractile organelle in V. cholerae and in E. coli, suggesting that sheath contraction powers the secretion.
Pfam PF09980: Predicted membrane protein (DUF2214) (family)
This domain, found in various hypothetical bacterial proteins, has no known function.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF04674: Phosphate-induced protein 1 conserved region (family)
Family of conserved plant proteins.  Conserved region identified in a phosphate-induced protein of unknown function.
Pfam PF13000: Acetyl-coenzyme A transporter 1 (family)
The mouse Acatn is a 61 kDa hydrophobic protein with six to 10 transmembrane domains. It appears to promote 9-O-acetylation in gangliosides.
Pfam PF11305: Protein of unknown function (DUF3107) (family)
Some members in this family of proteins are annotated as ATP-binding proteins however this cannot be confirmed. Currently no function is known.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF08639: DNA replication regulator SLD3, STD domain (domain)
The SLD3 DNA replication regulator is required for loading and maintenance of Cdc45 on chromatin during DNA replication. This entry represents the SLD3-Treslin domain (STD), which is shared with treslin, the metazoan counterpart, which differ in size and amino acid sequence. According to their similarities, it has been suggested that helicase activation in mammals has diverged in complexity during evolution from that in yeasts and may involve additional partners that interact with TopBP1.
Pfam PF09831: Uncharacterized protein conserved in bacteria (DUF2058) (family)
This domain, found in various prokaryotic proteins, has no known function.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF06853: Protein of unknown function (DUF1249) (domain)
This family consists of several hypothetical bacterial proteins of around 150 residues in length. The function of this family is unknown.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF17516: ProQ C-terminal domain (domain)
This domain is found at the C-terminus of many ProQ proteins.
Pfam PF17883: MBG domain (domain)
This domain is found in a variety of bacterial extracellular proteins. Although initially described as having a divergent Ig fold this domain has a novel topology that is like a mirror image of the beta grasp fold.  Hence the name of Mirror Beta Grasp (MBG) domain.
Pfam PF08826: DMPK coiled coil domain like (coiled_coil)
This domain is found in the myotonic dystrophy protein kinase (DMPK) and adopts a coiled coil structure.  It plays a role in dimerisation.
Pfam PF13628: Domain of unknown function (DUF4142) (domain)
This is a bacterial family of unknown function.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF07412: Geminin (family)
This family contains the eukaryotic protein geminin (approximately 200 residues long). Geminin inhibits DNA replication by preventing the incorporation of MCM complex into prereplication complex, and is degraded during the mitotic phase of the cell cycle. It has been proposed that geminin inhibits DNA replication during S, G2, and M phases and that geminin destruction at the metaphase-anaphase transition permits replication in the succeeding cell cycle.
Pfam PF12830: Sister chromatid cohesion C-terminus (repeat)
This domain lies towards the C-terminus of nipped-B or sister chromatid cohesion proteins.
Pfam PF24859: FdhE, central domain (domain)
This is the central domain of FdhE from Escherichia coli and similar proteins necessary for formate dehydrogenase activity. This domain is found associated with [pfam:PF04216].
Pfam PF24043: Domain of unknown function (DUF7352) (domain)
This entry represents a family of uncharacterised phage domains. These domains adopt a beta sandwich structure.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF23659: E3 UFM1-protein ligase 1-like domain (domain)
This domain is found in human E3 UFM1-protein ligase 1 (UFL1) and similar eukaryotic sequences. UFL1 mediates ufmylation, the covalent attachment of the ubiquitin-like modifier UFM1 to lysine residues on target proteins, which plays a key role in reticulophagy induced in response to endoplasmic reticulum stress. This domain, which is predicted to show an all-alpha configuration, is often found associated to [pfam:PF09743].
Pfam PF13148: Protein of unknown function (DUF3987) (family)
A family of uncharacterised proteins found by clustering human gut metagenomic sequences.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF22306: PAV1-137, bromodomain-like (domain)
This entry represents a Bromodomain-like domain present in PAV1-137 protein from PAV1 virus. Its function is unknown and it has been suggested that this domain could be involved in protein-protein interactions.
Pfam PF18117: Enhanced disease susceptibility 1 protein EP domain (domain)
The plant specific protein family, which comprises EDS1 (Enhanced disease susceptibility 1), PAD4 (Phytoalexin deficient4) and SAG101 (Senescence-associated gene 101), is involved in innate immunity [Ref.1]. Signaling by intracellular immune receptors with NB-ARC domain ([pfam:PF00931]) relies on this protein family. C-terminus of Arabidopsis EDS1 and PAD4 proteins did not have recognizable sequence homology to other domains and therefore named EP domain (EDS1-PAD4). A combination of an N-terminal lipase_3 domain ([pfam:PF01764]) and the C-terminal EP-domain is the defining feature of this family. Structurally, EP domain comprises exclusively of alpha-helices (PDB:4NFU). Structure-function analysis of Arabidopsis proteins showed that EDS1 forms heterodimers with PAD4 or SAG101, chiefly through the N-terminal lipase_3 domain. These heterodimers are essential for plant defense signaling. The EP domain is not stable without the lipase_3 domain, but is required for immunity. Mutations of conserved residues in the EP domain of EDS1 strongly affect its immune signaling function.
Pfam PF01625: Peptide methionine sulfoxide reductase (domain)
This enzyme repairs damaged proteins.  Methionine sulfoxide in proteins is reduced to methionine.
Pfam PF03977: Na+-transporting oxaloacetate decarboxylase beta subunit (family)
Members of this family are integral membrane proteins. The decarboxylation reactions they catalyse are coupled to the vectorial transport of Na+ across the cytoplasmic membrane, thereby creating a sodium ion motive force that is used for ATP synthesis.
Wikipedia: Oxaloacetate decarboxylase is a carboxy-lyase involved in the conversion of oxaloacetate into pyruvate.
Pfam PF08375: Proteasome regulatory subunit C-terminal (family)
This eukaryotic domain is found at the C-terminus of 26S proteasome regulatory subunits such as the non-ATPase Rpn3 subunit which is essential for proteasomal function.  It occurs together with the PCI/PINT domain ([pfam:PF01399]).
Pfam PF19700: Family of unknown function (DUF6198) (family)
This family represents a putative integral membrane protein that is likely to be the membrane component of an ABC transport system.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF23755: IP5P C-F Ig-like domain (repeat)
This entry represents the immunoglobulin-like domain found mainly in plant inositol polyphosphate 5-phosphatases (IP5P), such as Type I IP5P12/IP5PC and IP5P13/IP5PD and Type II IP5P14/IP5PE and IP5PF/IP5PF from Arabidopsis thaliana. IP5Ps have different functions, including the degradation of phosphoinositides in the signalling pathways of various cellular processes such as Ca2+ release, abscisic acid signalling and vesicle trafficking, among others. The function of this domain is unknown.
Pfam PF00534: Glycosyl transferases group 1 (family)
Mutations in this domain of [swissprot:P37287] lead to disease (Paroxysmal Nocturnal haemoglobinuria). Members of this family transfer activated sugars to a variety  of substrates, including glycogen, Fructose-6-phosphate and lipopolysaccharides. Members of this family transfer UDP, ADP,  GDP or CMP linked sugars. The eukaryotic glycogen synthases may be distant members of this family.
Pfam PF06153: Cyclic-di-AMP receptor (domain)
CdAMP is a family of bacterial cyclic-di-AMP receptor proteins. Cyclic-di-AMP (c-di-AMP) is a bacterial secondary messenger involved in various processes, including sensing of DNA-integrity, cell wall metabolism and potassium transport. CdAMP_rec has a ferredoxin-like fold and is structurally related to Pii-signal transduction proteins.
Pfam PF13028: Protein of unknown function (DUF3889) (domain)
This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 110 amino acids in length. There are two completely conserved residues (A and Y) that may be functionally important.
Pfam PF01674: Lipase (class 2) (domain)
This family consists of hypothetical C. elegans proteins and lipases. Lipases or triacylglycerol acylhydrolases hydrolyse ester bonds in triacylglycerol giving diacylglycerol, monoacylglycerol, glycerol  and free fatty acids. [swissprot:P37957] is a extracellular lipase from B. subtilis 168.
Pfam PF02558: Ketopantoate reductase PanE/ApbA (domain)
This is a family of 2-dehydropantoate 2-reductases also known as ketopantoate reductases, [ec:1.1.1.169].  The reaction catalysed by this  enzyme is: (R)-pantoate + NADP(+)  2-dehydropantoate + NADPH.  AbpA catalyses the NADPH reduction of ketopantoic acid to pantoic acid in the alternative pyrimidine biosynthetic (APB) pathway.  ApbA and PanE are allelic.  ApbA, the ketopantoate reductase enzyme is required for  the synthesis of thiamine via the APB biosynthetic pathway.
Pfam PF20974: tRNA synthetases class I (E and Q), anti-codon binding domain (domain)
This entry represents the second ribosomal L25 like domain which is part of the anticodon binding domain. Other tRNA synthetase sub-families are too dissimilar to be included. This family includes only glutamyl and glutaminyl tRNA synthetases. In some organisms, a single glutamyl-tRNA synthetase aminoacylates both tRNA(Glu) and tRNA(Gln).
Pfam PF03359: Guanylate-kinase-associated protein (GKAP) protein (family)
This entry represents the SAPAP family, whose members include mars from fruit flies and disks large-associated proteins from vertebrates.

Mars binds to microtubules and protein phosphatase 1. It is involved in cell signalling, mitotic spindle organisation and regulation of mitotic cell cycle . It is essential for the early development of Drosophila embryos .
Pfam PF04676: Protein similar to CwfJ C-terminus 2 (family)
This region is found in the N terminus of Schizosaccharomyces pombe protein CwfJ ([swissprot:Q09909]).  CwfJ is part of the Cdc5p complex involved in mRNA splicing.
Pfam PF24819: Domain of unknown function (DUF7710) (domain)
This entry represents a small family of uncharacterised bacterial proteins.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.