SII-SWORD/CoKE huggingface dataset:
Pfam PF07675: Cleaved Adhesin Domain (domain)
This is a family of bacterial protein modules thought to function in various roles including cell adhesion, cell lysis and carbohydrate binding.  A tandem repeat of these modules (either two or three repeats) constitute the haemagglutinin/adhesin (HA) regions of the gingipains, RgpA, [swissprot:Q51816] and Kgp, [swissprot:P72194] and [swissprot:P72197] expressed by Porphyromonas gingivalis (Bacteroides gingivalis).  They form components of the major extracellular virulence complex RgpA-Kgp - a mixture of proteinases and adhesin domains. The adhesin domains in this complex are found in proteinase-cleaved forms when isolated from the cell surface.  Haemagglutinin genes of P. gingivalis (hagA1 HAGA1_PORGI - [swissprot:P59915] - and hagA2 HAGA2_PORGI - [swissprot:Q51845]) suggest that such proteins are composed of eight to ten tandem repeats of these adhesin modules. Genomic data predicts that homologous protein modules are also expressed by a number of other bacteria and form part of putative multi-domain proteins, eg. [swissprot:Q26BR9] and [swissprot:B0VGL6]. These domains may be acting in concert with other adhesion modules thought to be part of these multi-domain proteins such as fibronectin type III, [pfam:PF00041], and Meprin, A5, mu (MAM), [pfam:PF00629], domains.
Pfam PF05314: Baculovirus occlusion-derived virus envelope protein EC27 (family)
This family consists of several baculovirus occlusion-derived virus envelope proteins (EC27 or E27). The ODV-E27 protein has distinct functional characteristics compared to cellular and viral cyclins. Depending on the cdk protein, and perhaps other viral or cellular proteins yet to be described, the kinase-EC27 complex may have either cyclin B- or  D-like activity.
Pfam PF12141: Beta-mannosyltransferases (family)
This entry represents a group of fungal beta-mannosyltransferase that are involved in cell wall biosynthesis. For example, in Candida albicans, BMT1-4 enzymes act stepwise to add beta-mannoses on to cell-wall phosphopeptidomannan (PPM). While Bmt5 and Bmt6 are involved in the addition of the first and third beta-mans to phospholipomannan (PLM), respectively. Furthermore, in Saccharomyces cerevisiae, BMT5 and BMT6 are responsible for methylation of uridine residues in the 25S rRNA.
Pfam PF01254: Nuclear transition protein 2 (family)
In mammals, the second stage of spermatogenesis is characterised by the conversion of nucleosomal chromatin to the compact, nonnucleosomal and transcriptionally inactive form found in the sperm nucleus. This condensation is associated with a double-protein transition. The first transition corresponds to the replacement of histones by several spermatid-specific proteins, also called transition proteins, which are themselves replaced by protamines during the second transition. Nuclear transition protein 2 (TP2) is one of those spermatid-specific proteins. TP2 is a basic, zinc-binding protein  of 116 to 137 amino-acid residues.

Structurally, TP2 consists of three distinct parts, a conserved serine-rich N-terminal domain of about 25 residues, a variable central domain of 20 to 50 residues which contains cysteine residues, and a conserved C-terminal domain of about 70 residues rich in lysines and arginines.
Pfam PF10149: Transmembrane protein 231 (family)
This is a family of transmembrane proteins, given the number 231, of unknown function. It is conserved in eukaryotes.
Pfam PF14145: YrhK-like protein (family)
The YrhK-like protein family includes the B. subtilis YrhK protein [swissprot:O05401] which is functionally uncharacterised.  Its expression is under the control of the motility sigma factor sigma-D.  This domain family is found in bacteria, archaea and eukaryotes, and is approximately 60 amino acids in length.
Pfam PF01569: PAP2 superfamily (family)
This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), Glucose-6-phosphatase [ec:3.1.3.9], Phosphatidylglycerophosphatase B [ec:3.1.3.27] and bacterial acid phosphatase [ec:3.1.3.2]. The family also includes a variety of haloperoxidases that function by oxidising halides in the presence of hydrogen peroxide to form the corresponding hypohalous acids.
Wikipedia: The enzyme phosphatidylglycerophosphatase (EC 3.1.3.27) catalyzes the following reaction:phosphatidylglycerophosphate + H2O  phosphatidylglycerol + phosphate
Pfam PF16291: Domain of unknown function (DUF4937 (family)
This family consists of uncharacterized proteins around 120 residues in length and is mainly found in various Bacillus species, such as Bacillus subtilis and Bacillus amyloliquefaciens. Several members are annotated as ydbC, but the specific function of this family is unknown.
Pfam PF19267: Contractile injection system spike tip protein (family)
This entry represents the spike tip protein from a contractile injection system. This entry includes Pvc10 (the homolog of T4 gp5.4). This protein was part of a CryoEM structure and although not resolved at atomic resolution in the map, it forms the sharp conical tip on the Pvc8 spike.
Pfam PF10214: Rrn6, beta-propeller (repeat)
RNA polymerase I-specific transcription-initiation factor Rrn6 is a component of a multisubunit core transcription factor, essential for the initiation of rDNA transcription by Pol I. The DNA-bound core factor (CF) resembles a right hand holding the DNA molecule between the fingers and the palm, with the thumb pointing toward Pol I. The palm is composed of the N-terminal regions of Rrn11 and Rrn6, the thumb is composed of the C-terminal of Rrn11 while the fingers and knuckles are composed of Rrn7 and the C-terminal half of Rrn6, respectively. This entry represents the beta-propeller domain of Rrn6 which is part of the palm (or module I in) of the CF which interacts with Rrn11.
Pfam PF00674: DUP family (domain)
This family consists of several yeast proteins of unknown functions.  Swiss-prot annotates these as belonging to the DUP family. Several members of this family contain an internal duplication of this region.
Pfam PF04775: Acyl-CoA thioester hydrolase/BAAT N-terminal region (family)
This family consists of the amino termini of acyl-CoA thioester hydrolase and bile acid-CoA:amino acid N-acetyltransferase (BAAT).  This region is not thought to contain the active site of either enzyme.  Thioesterase isoforms have been identified in peroxisomes, cytoplasm and mitochondria, where they are thought to have distinct functions in lipid metabolism.  For example, in peroxisomes, the hydrolase acts on bile-CoA esters.
Pfam PF22263: Family of unknown function (DUF6951) (family)
This is a family of uncharacterised proteins found in archaea and bacteria. These proteins are predicted to adopt similar structure to the members of SufE/NifU superfamily. They contain three invariant cysteine residues and a fourth semi-conserved residue either cysteine or histidine. These residues are likely to define a potential Zn-binding site similar to the binding site observed in SufU.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF17955: Cas6b N-terminal domain (domain)
Clustered, regularly interspaced, short palindromic repeat (CRISPR) loci play a pivotal role in the prokaryotic host defense system against invading genetic materials. The CRISPR loci are transcribed to produce CRISPR RNAs (crRNAs), which form interference complexes with CRISPR-associated (Cas) proteins to target the invading nucleic acid for degradation. Four Cas proteins (Cas5, Cas6b, Cas7 and Cas8b) are proposed to form a Type I-B Cascade complex that mediates the antiviral defense. This is the N-terminal domain found in Cas6b proteins. Cas6b is a member of Cas6 RNA processing endoribonucleases found in bacteria and archaea whose RNA substrates have a wide range of structural features. Cocrystal structures of Cas6 from Methanococcus maripaludis (MmCas6b) bound with its repeat RNA revealed a dual-site binding structure and a cleavage site conformation poised for phosphodiester bond breakage.
Wikipedia: CRISPR is a family of DNA sequences found in the genomes of prokaryotic organisms such as bacteria and archaea. Each sequence within an individual prokaryotic cell is derived from a DNA fragment of a bacteriophage that had previously infected the prokaryote or one of its ancestors. These sequences are used to detect and destroy DNA from similar bacteriophages during subsequent infections. Hence these sequences play a key role in the antiviral defense system of prokaryotes and provide a form of heritable, acquired immunity. CRISPR is found in approximately 50% of sequenced bacterial genomes and nearly 90% of sequenced archaea.
Pfam PF11118: Protein of unknown function (DUF2627) (family)
This family is conserved in the Bacillaceae family.  Several members are named as YqzF. The function is not known.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF02894: Oxidoreductase family, C-terminal alpha/beta domain (domain)
This family of enzymes utilise NADP or NAD. This family is called the GFO/IDH/MOCA family in swiss-prot.
Pfam PF16374: Cycle inhibiting factor (CIF) (family)
Cycle inhibiting factors (Cif) are bacterial effectors  that interfere with the eukarytoc cell cycle. CIF  induce an irreversible cell cycle arrest upon injection into host cell. CIF blocks degradation of cyclin -dependent kinase inhibitors p21 and p27, inducing  their accumulation in the cell. The x-ray crystal  structure of Cif reveals it to be a divergent member of a superfamily of enzymes including cysteine proteases and acetyltransferases.
Pfam PF18276: Tc toxin complex TcA C-terminal TcB-binding domain (domain)
This domain is found in the C-terminal region of the Tc toxin TcA, present in Photorhabdus luminescens. Tc Toxin complexes bind to the cell surface, are endocytosed and perforate the host endosomal membrane by forming channels that translocate toxic enzymes into the host. This domain is responsible for binding to toxin TcB. Binding of TcA to TcB/TcC opens the beta-propeller gate.
Pfam PF02742: Iron dependent repressor, metal binding and dimerisation domain (domain)
This family includes the Diphtheria toxin repressor. It acts as an iron-binding repressor of diphtheria toxin gene expression and may serve as a global regulator of gene expression. DTXR comprises an N-terminal DNA-binding domain, an interface domain (which contains two metal-binding sites) and a third, very flexible C-terminal domain. The second domain is responsible for dimerization and metal binding. Binding of DTXR to Tox operator requires a divalent metal ion such as cobalt, ferric, manganese and nickel whereas zinc shows weak activation. This domain can also bind Cd(II), Ca(II) and Cu(II) (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).
Wikipedia: In molecular biology, the iron dependent repressors are a family of bacterial and archaeal transcriptional repressors.
Pfam PF24382: Family of unknown function (DUF7538) (family)
This family includes a group of proteins from archaea. Members are predicted to adopt an alpha-beta structure.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF17993: Haemagglutinin 70 C-terminal domain (domain)
This is the C-terminal domain found in hemagglutinin component such as HA70 found in Clostridium botulinum. HA is a component of the large botulinum neurotoxin complex and is critical for its oral toxicity. HA plays multiple roles in toxin penetration in the gastrointestinal tract, including protection from the digestive environment, binding to the intestinal mucosal surface, and disruption of the epithelial barrier. HA consists of three different proteins, designated HA70 (also known as HA3), HA33 (HA1), and HA17 (HA2) based on molecular mass. HA70 consists of three domains (D1-3). The D1 and D2 domains, which adopt similar structures, mediate the trimerization of HA70 with each protomer. The D3 domain, sitting at the tip of the trimer, is composed of two similar jelly-roll-like beta-sandwich structures. Furthermore, crystal structures of HA70 in a complex with alpha2,3- or alpha2,6-SiaLac (alpha2,6-sialyllactose), show that alpha2,3- and alpha2,6-SiaLac bound to the same region in the D3 domain of HA70. This domain is the D3 domain found in HA3/HA70 which has been shown to be involved in binding to carbohydrate of glycoproteins from epithelial cells in the infection process.
Pfam PF08418: DNA polymerase alpha subunit B N-terminal (domain)
This is the eukaryotic DNA polymerase alpha subunit B N-terminal domain which is involved in complex formation. This domain docks on the SV40 helicase and activates the viral primosome.
Pfam PF10428: RAM signalling pathway protein (family)
SOG2 proteins in Saccharomyces cerevisiae are involved in cell separation and cytokinesis.
Pfam PF24151: FlaX (family)
This entry represents FlaX, a component of the Sulfolobus motility machinery (archaellum). This protein is conserved in crenarchaeal archaella and forms ring-shaped oligomers. Its C-terminal interacts with FlaI, the archaellum motor ATPase that is involved in assembly and rotation of the archaellum.
Pfam PF19737: Fukutin N-terminal (domain)
This is the N-terminal domain of fukutin, which contains the transmembrane domain required for its localisation to the Golgi and participates in the interaction with POMGnT1 for normal POMGnT1 location and activity. Fukutin is a ribitol-phosphate transferase that forms a complex with FKRP and TMEM5 which may contribute to specific biosynthesis of glycans required for dystroglycan function.
Pfam PF19622: Family of unknown function (DUF6127) (family)
This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and viruses. Proteins in this family are approximately 100 amino acids in length.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF11726: YagK/YfjJ C-terminal domain (domain)
This domain is found at the C-terminal of a group of uncharacterised proteins from bacteria, such as YagK and YfjJ from E.coli. This domain is structurally similar to viral Rep proteins and bacterial relaxases based on structure predictions and comparison, containing also the conserved HXH motif typically found in those proteins.
Pfam PF15865: Fanconi anaemia group A protein N terminus (repeat)
This entry represents the N-terminal domain of FANCA.
Fanconi anemia (FA) is a human disorder characterised by cancer susceptibility and cellular sensitivity to DNA crosslinks and other damages. The FA complex repairs the interstrand cross-linking (ICL) lesions and coordinates activities of the downstream DNA repair pathway including nucleotide excision repair, translesion synthesis, and homologous recombination. It is required for the monoubiquitylation of FANCD2 and FANCI heterodimer. The FA core complex consists of FANCA, FANCB, FANCC, FANCE, FANCF, FANCG, FANCL, FANCM, FANCT (UBET2), FAAP100 and FAAP24 .
Wikipedia: Fanconi anaemia, complementation group A, also known as FAA, FACA and FANCA, is a protein which in humans is encoded by the FANCA gene. It belongs to the Fanconi anaemia complementation group (FANC) family of genes of which 12 complementation groups are currently recognized and is hypothesised to operate as a post-replication repair or a cell cycle checkpoint. FANCA proteins are involved in inter-strand DNA cross-link repair and in the maintenance of normal chromosome stability that regulates the differentiation of haematopoietic stem cells into mature blood cells.
Pfam PF02562: PhoH-like protein (domain)
PhoH is a cytoplasmic protein and predicted ATPase that is induced by phosphate starvation.
Pfam PF12021: Protein of unknown function (DUF3509) (family)
This family of proteins is functionally uncharacterised. This protein is found in bacteria. Proteins in this family are typically between 92 to 110 amino acids in length. This protein has two completely conserved residues (G and R) that may be functionally important.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF13971: Meiosis-specific protein Mei4 (family)
This family of meiosis specific proteins is required for correct meiotic chromosome segregation and recombination. It is required for meiotic DNA double-strand break (DSB) formation.
Pfam PF22667: Lon protease AAA+ ATPase lid domain (domain)
This entry represents the AAA+ ATPase lid domain of Lon proteases.
Pfam PF04835: A9 protein conserved region (family)
Family of Chordopoxvirus A9 proteins.
Pfam PF03162: Tyrosine phosphatase family (domain)
This family is closely related to the [pfam:PF00102] and [pfam:PF00782] families.
Wikipedia: Protein tyrosine phosphatases (EC	3.1.3.48, systematic name protein-tyrosine-phosphate phosphohydrolase) are a group of enzymes that remove phosphate groups from phosphorylated tyrosine residues on proteins:[a protein]-tyrosine phosphate + H2O = [a protein]-tyrosine + phosphate
Pfam PF13096: CENP-A-nucleosome distal (CAD) centromere subunit, CENP-P (family)
CENP-P is one of the components that assembles onto the CENP-A-nucleosome distal (CAD) centromere. The centromere, which is the basic element of chromosome inheritance, is epigenetically determined in mammals. CENP-A, the centromere-specific histone H3 variant, assembles an array of nucleosomes and it is this that seems to be the prime candidate for specifying centromere identity. CENP-A nucleosomes directly recruit a proximal CENP-A nucleosome associated complex (NAC) comprised of CENP-M, CENP-N and CENP-T, CENP-U(50), CENP-C and CENP-H. Assembly of the CENP-A NAC at centromeres is dependent on CENP-M, CENP-N and CENP-T. Additionally, there are seven other subunits which make up the CENP-A-nucleosome distal (CAD) centromere, CENP-K, CENP-L, CENP-O, CENP-P, CENP-Q, CENP-R and CENP-S, also assembling on the CENP-A NAC. Fta7 is the equivalent component of the fission yeast Sim4 complex.
Pfam PF06706: Citrus tristeza virus 6-kDa protein (family)
This family consists of several Citrus tristeza virus (CTV) 6-kDa, 51 residue long hydrophobic (P6) proteins. The function of this family is unknown.
Pfam PF01237: Oxysterol-binding protein (family)
A number of eukaryotic proteins that seem to be involved with sterol synthesis and/or its regulation have been found  to be evolutionary related. These include mammalian oxysterol-binding protein (OSBP), a protein of about 800 amino-acid residues that binds a variety of oxysterols (oxygenated derivatives of cholesterol) ; yeast Osh1, a protein of 859 residues that also plays a role in ergosterol synthesis ; yeast proteins Hes1 and Kes1, highly related proteins of 434 residues that seem to play a role in ergosterol synthesis ; Probable transporter efuK from the fungi Hormonema carpetanum, which is involved in the biosynthesis of enfumafungin ; and OSBP-related proteins (ORP) from plants such as Arabidopsis thaliana .
Wikipedia: The oxysterol-binding protein (OSBP)-related proteins (ORPs) are a family of lipid transfer proteins (LTPs). Concretely, they constitute a family of sterol and phosphoinositide binding and transfer proteins in eukaryotes that are conserved from yeast to humans. They are lipid-binding proteins implicated in many cellular processes related with oxysterol, including signaling, vesicular trafficking, lipid metabolism, and nonvesicular sterol transport.
Pfam PF08444: Aralkyl acyl-CoA:amino acid N-acyltransferase, C-terminal region (family)
This family features the C-terminal region of several mammalian specific aralkyl acyl-CoA:amino acid N-acyltransferase (glycine N-acyltransferase) proteins [ec:2.3.1.13].
Pfam PF06658: Protein of unknown function (DUF1168) (family)
This family consists of several hypothetical eukaryotic proteins of unknown function.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.