SII-SWORD/CoKE huggingface dataset:
Pfam PF11084: Protein of unknown function (DUF2621) (family)
This family is conserved in the Bacillaceae family.  Several members are named as YneK. The function is not known.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF16193: AAA C-terminal domain (family)
AAA_assoc_2 is found at the C-terminus of a relatively small set of AAA domains in proteins ranging from archaeal to fungi, plants and mammals.
Pfam PF11109: Orexigenic neuropeptide Qrfp/P518 (family)
Qrfp/P518 has a direct role in maintaining bone mineral density. Qrfp has also found to be important in energy homeostasis by regulating appetite and energy expenditure in mice. The c-terminal 28 residues are the functional 26RFa.
Pfam PF02404: Stem cell factor (domain)
Stem cell factor (SCF) is a homodimer involved in hematopoiesis. SCF binds to and activates the SCF receptor (SCFR), a receptor tyrosine kinase. The crystal structure of human SCF has been resolved and a potential receptor-binding site identified.
Pfam PF13364: Beta-galactosidase second all-beta domain (domain)
This domain is the second all-beta domain from beta galactosidase enzymes which has a jelly roll fold. These enzymes consist of a TIM-barrel catalytic domain and two all-beta domains (ABD), ABD1 is represented in [pfam:PF21317] and this entry represents ABD2.
Pfam PF21544: TSS9, PorZ, N-terminal beta-propeller domain (repeat)
This domain is found at the N-terminal end of PorZ (also known as Immunoreactive 84kD antigen PG93) from Porphyromonas gingivalis and in similar proteins predominantly found in Bacteroidetes. PorZ is an essential component of the type-IX secretion system (T9SS) machinery. It consists of three domains. This entry represents the first domain, which folds into a seven-stranded beta-propeller.
Pfam PF09504: Bsp6I restriction endonuclease (family)
This family includes the Bsp6I (recognises and cleaves GC^NGC) restriction endonucleases.
Pfam PF16529: WD40 region of Ge1, enhancer of mRNA-decapping protein (repeat)
Ge1_WD40 is the N-terminal region of Ge-1 or enhancer of mRNA-decapping proteins. WD40-repeat regions are involved in protein-protein interactions.
Wikipedia: The WD40 repeat is a short structural motif of approximately 40 amino acids, often terminating in a tryptophan-aspartic acid (W-D) dipeptide. Tandem copies of these repeats typically fold together to form a type of circular solenoid protein domain called the WD40 domain.
Pfam PF05147: Lanthionine synthetase C-like protein (repeat)
Lanthionines are thioether bridges that are putatively generated by dehydration of Ser and Thr residues followed by addition of cysteine residues within the peptide. This family contains the lanthionine synthetase C-like proteins 1 and 2 which are related to the bacterial lanthionine synthetase components C (LanC). LANCL1 (P40 seven-transmembrane-domain protein) and LANCL2 (testes-specific adriamycin sensitivity protein) are thought to be peptide-modifying enzyme components in eukaryotic cells. Both proteins are produced in large quantities in the brain and testes and may have role in the immune surveillance of these organs. Lanthionines are found in lantibiotics, which are peptide-derived, post-translationally modified antimicrobials produced by several bacterial strains. This region contains seven internal repeats.
Pfam PF09857: Putative toxin of bacterial toxin-antitoxin pair (family)
YjhX_toxin is a putative toxin of a bacterial toxin-antitoxin pair, which is neutralised by the proteins YjhQ in family [pfam:PF00583].
Wikipedia: A toxin-antitoxin system consists of a "toxin" and a corresponding "antitoxin", usually encoded by closely linked genes. The toxin is usually a protein while the antitoxin can be a protein or an RNA. Toxin-antitoxin systems are widely distributed in prokaryotes, and organisms often have them in multiple copies. When these systems are contained on plasmids – transferable genetic elements – they ensure that only the daughter cells that inherit the plasmid survive after cell division. If the plasmid is absent in a daughter cell, the unstable antitoxin is degraded and the stable toxic protein kills the new cell; this is known as 'post-segregational killing' (PSK).
Pfam PF17826: Family of unknown function (DUF5588) (repeat)
This is a family of unknown function found in chordata.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF22481: Domain of unknown function (DUF6985) (domain)
This entry represents a family of bacterial domains of unknown function.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF16923: Glycosyl hydrolase family 63 N-terminal domain (domain)
This is a family of eukaryotic enzymes belonging to glycosyl hydrolase family 63. They catalyse the specific  cleavage of the non-reducing terminal glucose residue from Glc(3)Man(9)GlcNAc(2). Mannosyl oligosaccharide glucosidase [ec:3.2.1.106] is the first enzyme in the N-linked oligosaccharide processing pathway. This family represents the N-terminal beta sandwich domain.
Wikipedia: In molecular biology, glycoside hydrolase family 63 is a family of glycoside hydrolases.
Pfam PF06032: S-Me-THD-like, N-terminal domain (domain)
This 3-layer(aba) sandwich domain is found at the N terminus of S-methyl thiohydantoin desulfurase from Variovorax sp. (S-Me-THD) and similar sequences mainly found in bacteria and fungi. S-Me-THD catalyses the hydrolysis of S-methyl -thiohydantoin-5-propanoate into hydantoin-5-propanoate and methanethiol, the third step in S-methyl ergothioneine degradation.
Pfam PF15007: Centrosomal spindle body, CEP44 (family)
CEP44 is a coiled coil domain found localised in the centrosome and spindle poles.
Pfam PF05655: Pseudomonas avirulence D protein (AvrD) (family)
This family consists of several avirulence D (AvrD) proteins primarily found in Pseudomonas syringae.
Pfam PF01337: Barstar (barnase inhibitor) (domain)
Barstar is a small single chain protein. Barnase is the extracellular ribonuclease IPR001887 of Bacillus amyloliquefaciens, and barstar its specific intracellular inhibitor . Expression of barstar is necessary to counter the lethal effect of expressed active barnase.
The structure of the barstar consists of two layers of parallel Î²-sheet of three strands. Barstar inhibits barnase by statically blocking the active site with a helix and adjacent loop segment .
Wikipedia: Barstar is a small protein synthesized by the bacterium Bacillus amyloliquefaciens. Its function is to inhibit the ribonuclease activity of its binding partner barnase, with which it forms an extraordinarily tightly bound complex within the cell until barnase is secreted. Expression of barstar is necessary to counter the lethal effect of expressed active barnase. The structure of the barnase-barnstar complex is known.
Pfam PF12541: Protein of unknown function (DUF3737) (repeat)
This family of proteins is found in bacteria, archaea and eukaryotes. Proteins in this family are typically between 281 and 297 amino acids in length.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF06418: CTP synthase N-terminus (domain)
This family consists of the N-terminal region of the CTP synthase protein ([ec:6.3.4.2]). This family is found in conjunction with [pfam:PF00117] located in the C-terminal region of the protein. CTP synthase catalyses the synthesis of CTP from UTP by amination of the pyrimidine ring at the 4-position.
Pfam PF14790: Tetrahydrodipicolinate N-succinyltransferase N-terminal (domain)
This is the N-terminal domain of 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase.
Pfam PF20909: Endo-alpha-N-acetylgalactosaminidase, helical bundle domain (domain)
This domain is found in Endo-alpha-N-acetylgalactosaminidase (SpGH101) from Streptococcus pneumoniae and similar bacterial proteins. This protein, which belongs to the Glycoside Hydrolase Family 101 (GH101), is a virulence factor. It hydrolyses the T-antigen disaccharide from extracellular host glycoproteins to aid colonization. SpGH101 has seven domains. This entry represents the helical bundle domain, which consists of three alpha-helices that form an interface.
Pfam PF17604: Family of unknown function (DUF5500) (family)
This is a family of unknown function found in Herpesvirus.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF04305: Protein of unknown function (DUF455) (family)
This is a family of uncharacterised proteins.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF17481: Phage tail sheath protein beta-sandwich domain (domain)
This entry represents a two-layer beta sandwich domain found in a variety of phage tail sheath proteins, referred to as domain II in. Domain I and II form the protease-resistant fragment.
Pfam PF18625: ESX-1 secreted protein B PE domain (domain)
The ESX-1 secretion system is an important virulence determinant in Mycobacterium tuberculosis.  ESX-1 secreted protein B (EspB) contains putative PE (Pro-Glu) and PPE (Pro-Pro-Glu) domains, and a C-terminal domain, which is processed by MycP1 protease during secretion. This domain represents the PE domain located at the N-terminal region of EspB which carries the conserved YxxxD/E secretion motif.
Pfam PF09240: Interleukin-6 receptor alpha chain, binding (domain)
Members of this family adopt a structure consisting of an immunoglobulin-like beta-sandwich, with seven strands in two beta-sheets, in a Greek-key topology. They are required for binding to the cytokine Interleukin-6.
Wikipedia: Type I cytokine receptors are transmembrane receptors expressed on the surface of cells that recognize and respond to cytokines with four α-helical strands. These receptors are also known under the name hemopoietin receptors, and share a common amino acid motif (WSXWS) in the extracellular portion adjacent to the cell membrane. Members of the type I cytokine receptor family comprise different chains, some of which are involved in ligand/cytokine interaction and others that are involved in signal transduction.
Pfam PF18955: Domain of unknown function (DUF5698) (family)
This family is functionally uncharacterised. This family family is found in bacteria and archaea, and is approximately 60 amino acids in length and contains two probable transmembrane helices. This entry is found in association with [pfam:PF10035]. The C-terminal transmembrane helix contains a GXXXGXXXG motif that is characteristic of transmembrane helices that dimerise.
Pfam PF19230: Family of unknown function (DUF5883) (family)
This is a family of uncharacterised proteins of unknown function predominantly found in Phycodnavirus.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF15061: Domain of unknown function (DUF4538) (family)
This protein family is thought to be a transmembrane helix. Its function remains unknown. This family of proteins is found in eukaryotes. Proteins in this family are typically between 58 and 87 amino acids in length.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF10098: Uncharacterised protein conserved in bacteria (DUF2336) (family)
Members of this family of hypothetical bacterial proteins have no known function.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF20066: Glyoxalase superfamily protein (domain)
This presumed domain is functionally uncharacterised. This domain family is found in bacteria, and is approximately 80 amino acids in length. This domain is part of the Glyoxalase superfamily.
Pfam PF00766: Electron transfer flavoprotein FAD-binding domain (domain)
This domain found at the C-terminus of electron transfer flavoprotein alpha chain and binds to FAD. The fold consists of a five-stranded parallel beta sheet as the core of the domain, flanked by alternating helices.  A small part of this domain is donated by the beta chain.
Wikipedia: An electron transfer flavoprotein (ETF) or electron transfer flavoprotein complex (CETF) is a flavoprotein located on the matrix face of the inner mitochondrial membrane and functions as a specific electron acceptor for primary dehydrogenases, transferring the electrons to terminal respiratory systems such as electron-transferring-flavoprotein dehydrogenase. They can be functionally classified into constitutive, "housekeeping" ETFs, mainly involved in the oxidation of fatty acids, and ETFs produced by some prokaryotes under specific growth conditions, receiving electrons only from the oxidation of specific substrates.
Pfam PF12169: DNA polymerase III subunits gamma and tau domain III (family)
This domain family is found in bacteria, and is approximately 110 amino acids in length. The family is found in association with [pfam:PF00004]. Domains I-III are shared between the tau and the gamma subunits, while most of the DnaB-binding Domain IV and all of the alpha-interacting Domain V are unique to tau.
Pfam PF19335: Heavy metal binding domain (domain)
This domain is a copper-binding domain found in single or multiple copies at the N-terminus of a wide variety of copper or other heavy metal binding transporters and other proteins.
Pfam PF07516: SecA Wing and Scaffold domain (family)
SecA protein binds to the plasma membrane where it interacts with proOmpA to support translocation of proOmpA through the membrane.  SecA protein achieves this translocation, in association with SecY protein, in an ATP  dependent manner. This family is composed of two C-terminal alpha helical subdomains: the wing and scaffold subdomains.
Pfam PF03682: Uncharacterised protein family (UPF0158) (family)
This is a small family of hypothetical bacterial proteins of unknown function.
Pfam PF24239: Family of unknown function (DUF7447) (family)
This entry represents an uncharacterized family found in various bacteriophage proteins. It is predominantly found in phages infecting diverse bacterial species including Burkholderia, Bacillus, Streptomyces, Listeria, and Caulobacter. The proteins are typically around 100-150 amino acids in length. Many of the proteins containing this domain are annotated as uncharacterized or hypothetical proteins. The proteins form a compact domain composed of a four stranded antiparallel beta sheet.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF18804: CxC3 like cysteine cluster associated with KDZ transposases (domain)
A predicted Zinc chelating domain present N-terminal to the KDZ transposase domain.
Pfam PF06715: Gp5 C-terminal repeat (3 copies) (repeat)
This repeat composes the C-terminal part of the bacteriophage T4 baseplate protein Gp5.  This region of the protein forms a needle like projection from the baseplate that is presumed to puncture the bacterial cell membrane. Structurally three copies of the repeated region trimerise to form a beta solenoid type structure. This family also includes repeats from bacterial Vgr proteins.
Pfam PF12480: Golgi associated RAB2 interactor protein-like, Rab2B-binding domain (domain)
This domain is found in Golgi associated RAB2 interactor proteins and it is likely a Rab2B-binding domain. Some members included in this entry, such as GAR1A/B and GAR2, are RAB2B effector proteins required for accurate acrosome formation and normal male fertility. GARI-L4 is a RAB2B effector protein required for the compacted Golgi morphology. GARIL5 is a Rab2B effector protein which promotes cytosolic DNA-induced innate immune responses.
Pfam PF15214: Peroxisomal testis-specific protein 1 (family)
This family of proteins is testis-specific.
Pfam PF21498: Oxalate biosynthetic component 1, C-terminal (domain)
This domain is found at the C-terminal end of a group of proteins from proteobacteria and fungi, including the bifunctional enzyme Oxalate biosynthetic component 1 from Burkholderia pseudomallei (Obc1, [swissprot:Q63KK6]). This domain is usually found in association with [pfam:PF05853] and [pfam:PF20913].
Pfam PF09936: SAM-dependent RNA methyltransferase (family)
This family has a Rossmanoid fold, with a deep trefoil knot in its C-terminal region. It has structural similarity to RNA methyltransferases, and is likely to function as an S-adenosyl-L-methionine (SAM)-dependent RNA 2'-O methyltransferase.
Pfam PF13437: HlyD family secretion protein (family)
This is a family of largely bacterial haemolysin translocator HlyD proteins.
Pfam PF05955: Equine herpesvirus glycoprotein gp2 (family)
This family consists of a number of glycoprotein gp2 sequences from equine herpesviruses.
Pfam PF06742: Protein of unknown function (DUF1214) (domain)
This family represents the C-terminal region of several hypothetical proteins of unknown function. Family members are mostly bacterial, but a few are also found in eukaryotes and archaea.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF20165: KBTB, W-type LIR motif (conserved_site)
LC3 Interacting Regions (LIRs), also known as ATG8-interacting motifs (AIMs), are short-linear motifs (SLiMs) of autophagy receptors and adaptor proteins that facilitates the selective recruitment of autophagy substrates to the autophagosome. ATG8 proteins are highly conserved in eukaryotes and play a key role in selective autophagy as they recognise and bind different autophagy receptors and adaptors containing a specific class of SLiMs. LIRs are characterised by degenerated sequences with a four-residue core central sequence involved in ATG8-binding, with the W/Y/FxxL/I/V pattern. Based on the aromatic amino acid in position 1 they can be classified into W-type, Y-type and F-type. This is the W-type LIR motif from Kelch repeat and BTB domain-containing proteins (KBTBs), characterised by the core LIR sequence WVxV.
Pfam PF07848: PaaX-like protein (family)
This family contains proteins that are similar to the product of the paaX gene of Escherichia coli ([swissprot:P76086]). This protein  is involved in the regulation of expression of a group of proteins  known to participate in the metabolism of phenylacetic acid.  In fact, some members of this family are annotated by InterPro as  containing a winged helix DNA-binding domain (Interpro:IPR009058).
Pfam PF20444: Family of unknown function (DUF6703) (family)
This family of putative integral membrane proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 85 and 118 amino acids in length.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF14361: RsbT co-antagonist protein rsbRD N-terminal domain (domain)
This domain is found at the N-terminus of a number of anti-sigma-factor antagonist proteins including B. subtilis RsbRD, [swissprot:P54504]. These proteins are negative regulators of the general stress transcription factor sigma(B). It is found in association with [pfam:PF01740].
Pfam PF24287: Family of unknown function (DUF7475) (family)
This family includes a group of proteins from archaea. Members are predicted to adopt an alpha-helical structure.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF14807: Adaptin AP4 complex epsilon appendage platform (domain)
This domain is found at the C terminal of clathrin-adaptor epsilon subunit, and at the C-terminus of the appendage on the platform domain.