SII-SWORD/CoKE huggingface dataset:
Pfam PF01959: 3-dehydroquinate synthase II (family)
This family includes members of 3-dehydroquinate synthase II ([ec:1.4.1.24]), encoded by aroB genes in M. maripaludis which is widely distributed in methanogens. In M. jannaschii, proteins ADTH synthase (AroA) and DHQ synthase II (AroB) are required to convert 6-deoxy-5-ketofructose-1-phosphate (DKFP) and aspartate semialdehyde to 3-dehydroquinate (DHQ) in vitro.
Wikipedia: 3-dehydroquinate synthase II (EC 1.4.1.24, DHQ synthase II, MJ1249 (gene), aroB' (gene)) is an enzyme with systematic name 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate:NAD+ oxidoreductase (deaminating). This enzyme catalyses the following chemical reaction2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate + H2O + NAD+  3-dehydroquinate + NH3 + NADH + H+
Pfam PF10188: Organic solute transport protein 1 (family)
Oscp1 is a family of proteins conserved from plants to humans. It is called organic solute transport protein or oxido-red- nitro domain-containing protein 1, however no reference could be find to confirm the function of the protein.
Pfam PF12187: Viral/Archaeal nuclease (domain)
This family of proteins is found in archaea and viruses. Proteins in this family are typically between 211 and 244 amino acids in length. These proteins are nucleases from fusseloviruses and sulfolobus archaea.
Pfam PF21065: Reovirus core-spike protein lambda-2 (L2), methyltransferase-1 (domain)
Reovirus core-spike protein VP1/lambda-2 (VP1/L2) forms a pentamer that mediates enzymatic reactions in 5' capping of the viral plus-strand transcripts. It forms a hollow cylinder with projecting turrets. Each VP1/L2 monomer consists of eight domains with the most N-terminal domain at the base of the turret and the most C-terminal domain at the top. This entry represents the methyltransferase-1 domain which adds a methyl group to the N7 of the guanosine added by the GTase.
Pfam PF10142: PhoPQ-activated pathogenicity-related protein (family)
Members of this family of bacterial proteins are involved in the virulence of some pathogenic proteobacteria.
Pfam PF01512: Nuo51 FMN-binding domain (domain)
This entry represents the FMN-binding domain of NADH-ubiquinone oxidoreductase 51kDa subunit from NADH:ubiquinone oxidoreductase.
Wikipedia: Respiratory complex I, EC 7.1.1.2 is the first large protein complex of the respiratory chains of many organisms from bacteria to humans. It catalyzes the transfer of electrons from NADH to coenzyme Q10 (CoQ10) and translocates protons across the inner mitochondrial membrane in eukaryotes or the plasma membrane of bacteria.
Pfam PF03824: High-affinity nickel-transport protein (family)
High affinity nickel transporters involved in the incorporation of nickel into H2-uptake hydrogenase and urease enzymes. Essential for the expression of catalytically active hydrogenase and urease. Ion uptake is dependent on proton motive force. HoxN in Alcaligenes eutrophus is thought to be an integral membrane protein with seven transmembrane helices. The family also includes a cobalt transporter.
Pfam PF20531: Family of unknown function (DUF6746) (family)
This family of proteins is functionally uncharacterised. This family of proteins is found in proteobacteria. Proteins in this family are approximately 130 amino acids in length.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF08043: Xin repeat (repeat)
The repeat has the consensus sequence GDV(K/Q/R)(T/S/G)X(R/K/T) WLFETXPLD.  This repeat motif is typically found in the N-terminus of the proteins, with a copy number between 2 and 28 repeats.  Direct evidence for binding to and stabilising F-actin has been found in the human protein [swissprot:Q702N9]. The homologues in mouse and chicken localise in the adherens junction complex of the intercalated disc in cardiac muscle and in the myotendon junction of skeletal muscle. mXin may co-localise with Vinculin which is known to attach the actin to the cytoplasmic membrane. It has been shown that the amino-terminus of human xin (CMYA1) binds the EVH1 domain of Mena/VASP/EVL, and the carboxy-terminus binds the, for the filamin family unique, domain 20 of filaminC. This confirms the proposed role of xin repeat containing proteins as F-actin-binding adapter proteins.
Pfam PF21467: Beta-galactosidase, galactose-binding domain (domain)
Beta-galactosidase belongs to Glycoside hydrolase family 35. This entry represents the galactose-binding domain.
Pfam PF18421: Peptidase family M23 N-terminal domain (domain)
This is the N-terminal domain of Peptidase M23 [pfam:PF01551] mostly found in proteobacteria.
Pfam PF07180: CaiF/GrlA transcriptional regulator (family)
This is a family of transcriptional regulators. CaiF is involved in carnitine metabolism. GrlA is encoded within the LEE type III  secretion system in the enteropathogenic E. coli O157:H. GrlR interacts with GrlA at its Helix-Turn-Helix (HTH) motif, preventing GrlA from binding to its target promoter DNA.
Pfam PF01816: Leucine rich repeat variant (repeat)
The function of this repeat is unknown. It has an unusual structure of two helices. One is an alpha helix, the other is the much rarer 3-10 helix.
Wikipedia: A leucine-rich repeat (LRR) is a protein structural motif that forms an α/β horseshoe fold. It is composed of repeating 20–30 amino acid stretches that are unusually rich in the hydrophobic amino acid leucine. These tandem repeats commonly fold together to form a solenoid protein domain, termed leucine-rich repeat domain. Typically, each repeat unit has beta strand-turn-alpha helix structure, and the assembled domain, composed of many such repeats, has a horseshoe shape with an interior parallel beta sheet and an exterior array of helices. One face of the beta sheet and one side of the helix array are exposed to solvent and are therefore dominated by hydrophilic residues. The region between the helices and sheets is the protein's hydrophobic core and is tightly sterically packed with leucine residues.
Pfam PF13006: Insertion element 4 transposase N-terminal (family)
This family represents the N-terminal region of proteins carrying the transposase enzyme, DDE_Tnp_1 (that was Transposase_11), [pfam:PF01609], at the C-terminus. The full-length members are Insertion Element 4, IS4. Within the collection of E.coli strains, ECOR, the number of IS4 elements varies from zero to 14, with an average of 5 copies/strain.
Pfam PF11578: Protein of unknown function (DUF3237) (family)
This family of proteins has no known function
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF20347: Family of unknown function (DUF6642) (family)
This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 186 and 200 amino acids in length.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF22091: Family of unknown function (DUF6941) (family)
This is a family of uncharacterised bacterial proteins. They share sequence similarity to Ig-like domains found in a number of proteins such as xylosyltransferase, alkylpurine DNA glycosylase, cycloisomaltooligosaccharide glucanotransferase and are predicted to adopt the same structure.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF15712: NPAT C terminus (family)
Protein NPAT is required for progression through the G1 and S phases of the cell cycle, and for S phase entry . It regulates histone gene expression as well as nonhistone targets that influence competency for cell cycle progression .

This entry represents the C-terminal domain of NPAT.
Wikipedia: Protein NPAT also known as nuclear protein of the ATM locus is a protein that in humans is encoded by the NPAT gene.
Pfam PF24113: Family of unknown function (DUF7387) (family)
This entry includes uncharacterised archaeal sequences.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF07179: SseB protein N-terminal domain (domain)
This family consists of several SseB proteins which appear to be found exclusively in Enterobacteria. SseB is known to enhance serine-sensitivity in Escherichia coli and is part of the Salmonella pathogenicity island 2 (SPI-2) translocon. This entry contains the presumed N-terminal domain of SseB.
Pfam PF06281: Structural protein VP1/VP3 (family)
This family consists of Structural proteins VP1 and VP3 from Sulfolobus spindle-shape virus 1 (SSV1), two of the three structural proteins.
Pfam PF12305: Protein of unknown function (DUF3630) (family)
This family of proteins is found in bacteria. Proteins in this family are approximately 100 amino acids in length. There is a single completely conserved residue D that may be functionally important.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF24771: CFAP74 first Ig-like domain (domain)
This entry represents the first Ig-like domain of CFAP74, a protein that is part of the central apparatus of the cilium axoneme and may play a role in cilium movement. It may play an important role in sperm architecture and function.
Pfam PF10021: Microbial-type PARG, catalytic domain (domain)
Poly(ADP-ribose) glycohydrolase (PARG) hydrolyses the ribose-ribose bonds present in poly(ADP-ribose) (PAR) chains. This entry represents the PARG homologue present in bacteria and fungi. Its structure shows a typical macrodomain folding consisting of a seven-stranded beta-sheet sandwiched between nine alpha-helices.
Pfam PF18468: Phosphofructokinase N-terminal domain yeast (domain)
This is a phosphofructokinase (Pfk) N-terminal domain found in yeast ATP-dependent 6-phosphofructokinase subunit alpha. ATP-dependent 6-phosphofructokinases (Pfks, EC 2.7.1.11) catalyze the phosphorylation of fructose 6-phosphate (F-6-P) to fructose 1,6-bisphosphate, a key control step of glycolysis in most organisms. The N-terminal domain contains the active site and is related to glyoxalase I (E.C. 4.4.1.5).
Wikipedia: Phosphofructokinase (PFK) is a kinase enzyme that phosphorylates fructose 6-phosphate in glycolysis.
Pfam PF00166: Chaperonin 10 Kd subunit (domain)
This family contains GroES and Gp31-like chaperonins. Gp31 is a functional co-chaperonin that is required for the folding and assembly of Gp23, a major capsid protein, during phage morphogenesis.
Wikipedia: Heat shock 10 kDa protein 1 (Hsp10), also known as chaperonin 10 (cpn10) or early-pregnancy factor (EPF), is a protein that in humans is encoded by the HSPE1 gene. The homolog in E. coli is GroES that is a chaperonin which usually works in conjunction with GroEL.
Pfam PF18187: TbRIF5 SNase domain 1 (domain)
Staphylococcus nuclease (SNase) domain family found in the Trypanosoma brucei TbRIF5 protein, which could contribute to the processing of dsRNA targets.
Pfam PF11731: Pathogenicity locus (family)
Cdd1 is expressed as part of the pathogenicity locus operon in several different orders of bacteria. Many members of the family are annotated as being putative mitomycin resistance proteins but this could not be confirmed.
Pfam PF13781: DoxX-like family (family)
This family of uncharacterised proteins are related to DoxX [pfam:PF07681].
Pfam PF22699: GEM-interacting protein-like, FCH domain (domain)
This entry represents the FCH (FER-CIP4 homology) domain (part of the F-BAR domain) found at the N-terminal end of GEM-interacting protein from humans (GMIP), which stimulates the GTPase activity of RhoA. This domain folds into an all-alpha configuration.
Pfam PF11733: Non-capsid protein NP1 (family)
This family is the non-capsid protein NP1 of the ssDNA, Parvovirinae virus Bocavirus of cattle and humans.
Pfam PF10804: Protein of unknown function (DUF2538) (family)
This family of proteins has no known function.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF16390: Domain of unknown function (family)
This family around 75 residues locates in the N-terminal of F5/8 type C domain proteins and some uncharacterized proteins in various Bacteroides species. The function of this family remains unknown.
Pfam PF11627: Heterogeneous nuclear ribonucleoprotein A1, LC domain (domain)
This entry includes hnRNPA1, a nuclear factor that binds to Pol II transcripts. The family of hnRNP proteins are involved in numerous RNA-related activities. hnRNPA1 is involved in the packaging of pre-mRNA into hnRNP particles, transport of poly(A) mRNA from the nucleus to the cytoplasm and modulation of splice site selection. hnRNPA1 plays a role in the splicing of pyruvate kinase PKM by binding repressively to sequences flanking PKM exon 9, inhibiting exon 9 inclusion and resulting in exon 10 inclusion and production of the PKM M2 isoform. This protein binds to the IRES and inhibits the translation of the apoptosis protease activating factor APAF1. During Enterovirus 71 (EV71) infection, APAF1 expression is essential for virus-induced apoptosis and viral particle release. HnRNPA1 has two RNA recognition motifs (RRM1 and RRM2) followed by an unstructured low complexity (LC) C-terminal domain, represented in this entry. This domain can mediate protein-protein and protein-RNA interactions and it is involved in amyloid aggregation, leading to neurodegenerative diseases including amyotrophic lateral sclerosis (ALS) and multisystem proteinopathy (MSP).
Pfam PF04825: N terminus of Rad21 / Rec8 like protein (family)
This family represents a conserved N-terminal region found in eukaryotic  cohesins of the Rad21, Rec8 and Scc1 families. Members of this family  mediate sister chromatid cohesion during mitosis and meiosis, as part of  the cohesin complex. Cohesion is necessary for homologous recombination (including double-strand break repair) and correct chromatid segregation. These proteins may also be involved in chromosome condensation. Dissociation at the metaphase to  anaphase transition causes loss of cohesion and chromatid segregation.
Pfam PF09621: Type III secretion system regulator (LcrR) (family)
This family of proteins are encoded within type III secretion operons and have been characterised in Yersinia as a regulator of the Low-Calcium Response (LCR).
Pfam PF21948: Lipoyl protein ligase A/B catalytic domain (domain)
This entry represents the catalytic domain of a group of lipoyl ligases/lipoyltransferases, such as Lipoate-protein ligase A/B (LipA/B) from E.coli and mammalian lipoyltransferases. These proteins catalyse the transfer of the lipoyl group from lipoyl-AMP to the specific lysine residue of lipoyl domains of lipoate-dependent enzymes. Lipoic acid is an essential cofactor of the alpha-ketoacid dehydrogenase complexes and the glycine cleavage system.
Pfam PF12821: Threonine/Serine exporter, ThrE (domain)
ThrE_2 is a family of membrane proteins involved in the export of threonine and serine. L-threonine, L-serine are both substrates for the exporter. The exporter exhibits nine-ten predicted transmembrane-spanning helices with long charged C and N termini and an amphipathic helix present within the N terminus. L-Threonine can be made by the amino acid-producing bacterium Corynebacterium glutamicum, but the potential for amino acid formation can be considerably improved by reducing its intracellular degradation into glycine and increasing its export by this exporter. Members of the family are found in Bacteria, Archaea, and the fungal kingdoms, and the family can exist either as a single long polypeptide chain or as two short polypeptides. All family members show an extended hydrophilic N-terminal domain with weak sequence similarity to portions of hydrolases (proteases, peptidases, and glycosidases); this suggests that since this region is cytoplasmic to the membrane it may be generating the transport substrate, so may imply that threonine may not be the primary substrate and the ThrE has a subsidiary function.
Pfam PF20393: Putative carbonic anhydrase (domain)
This family of proteins are likely to be prokaryotic carbonic anhydrase enzymes related to [pfam:PF00484].. This family of proteins is found in bacteria and archaea. Proteins in this family are approximately 130 amino acids in length.
Pfam PF04547: Calcium-activated chloride channel (family)
The family carries eight putative transmembrane domains, and, although it has no similarity to other known channel proteins, it is clearly a calcium-activated ionic channel. It is expressed in various secretory epithelia, the retina and sensory neurons, and mediates receptor-activated chloride currents in diverse physiological processes.
Wikipedia: The Calcium-Dependent Chloride Channel (Ca-ClC) proteins (or calcium-activated chloride channels, are heterogeneous groups of ligand-gated ion channels for chloride that have been identified in many epithelial and endothelial cell types as well as in smooth muscle cells. They include proteins from several structurally different families: chloride channel accessory, bestrophin, and calcium-dependent chloride channel anoctamin channels ANO1 is highly expressed in human gastrointestinal interstitial cells of Cajal, which are proteins which serve as intestinal pacemakers for peristalsis. In addition to their role as chloride channels some CLCA proteins function as adhesion molecules and may also have roles as tumour suppressors. These eukaryotic proteins are "required for normal electrolyte and fluid secretion, olfactory perception, and neuronal and smooth muscle excitability" in animals. Members of the Ca-CIC family are generally 600 to 1000 amino acyl residues in length and exhibit 7 to 10 transmembrane segments.
Pfam PF20485: Family of unknown function (DUF6724) (family)
This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 62 and 74 amino acids in length.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF20541: Family of unknown function (DUF6756) (family)
This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 159 and 191 amino acids in length.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF23962: Domain of unknown function (DUF7290) (domain)
This entry represents a small family of uncharacterised proteins found in enterobacteria phages. The proteins are around 80 residues in length. The proteins assume a compact domain that has four beta strands forming a sheet followed by three alpha helices packed on one side.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.