SII-SWORD/CoKE huggingface dataset:
Pfam PF19232: Family of unknown function (DUF5885) (family)
This is a family of uncharacterised proteins of unknown function found in viruses.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF00910: RNA helicase (domain)
This family includes RNA helicases thought to be involved in duplex unwinding during viral RNA replication. Members of this family are found in a variety of single stranded RNA viruses.
Pfam PF04831: POPDC1-3 (domain)
This entry includes proteins from POPDC family, also known as the Popeye (POP) family, which includes POPDC1, 2 and 3 and is mainly restricted to vertebrates. It is preferentially expressed in developing and adult striated muscle. These proteins act as cAMP effectors and play a role in cardiac pacemaking and conduction. The PODC proteins have been shown to regulate potassium and sodium channels. PODC1 has been associated with phenotypes including limb-girdle muscular dystrophy-25, cardiac arrhythmia and changes in PODC protein expression have been linked to many cancers. POPDC3 may play a role in the maintenance of heart function mediated, through cAMP-binding and it is also important for skeletal muscle function. Pathogenic variants in POPDC3 are responsible for a novel type of autosomal recessive limb girdle muscular dystrophy.
Wikipedia: Popeye protein conserved region is common to a family of evolutionarily related proteins, the Popeye domain containing (POPDC) family of proteins, which is found in many animal phyla.
Pfam PF04048: Exocyst complex component Sec8 N-terminal (repeat)
Sec8 is a component of the exocyst complex, composed of Sec3, Sec5, Sec6, Sec8, Sec10, Sec15, Exo70 and Exo84, which mediates the tethering of post-Golgi secretory vesicles to the plasma membrane. The exocyst promotes the assembly of SNARE complex for membrane fusion and it is also involved in cell polarisation, primary ciliogenesis, cytokinesis, pathogen invasion, tumourigenesis and metastasis. Subunits of the exocyst have a rod structure which is a shared feature for the Complex Associated with Tethering Containing Helical Rods (CATCHRs) proteins, such as those of the Conserved Oligomeric Golgi complex (COG) and Golgi-Associated Retrograde Protein complex (GARP), consisting of a N-terminal long coiled-coil followed by a region of anti-parallel short helical bundle units. This entry represents the conserved coiled-coil region at the N-terminal of Sec8 proteins, which interacts with Sec6 and form an antiparallel zipper. This zipper then interacts with that formed between Sec3-Sec5, to assemble in a four-helical bundle.
Pfam PF01505: Major Vault Protein repeat domain (domain)
The vault is a ubiquitous and highly conserved ribonucleoprotein particle of approximately 13 mDa of unknown function. This family corresponds to a repeated domain found in the amino terminal half of the major vault protein.
Wikipedia: The vault or vault cytoplasmic ribonucleoprotein is a eukaryotic organelle whose function is not yet fully understood. Discovered and isolated by Nancy Kedersha and Leonard Rome in 1986, vaults are cytoplasmic structures which, when negative-stained and viewed under an electron microscope, resemble the arches of a cathedral's vaulted ceiling, with 39-fold symmetry. They are present in many types of eukaryotic cells and appear to be highly conserved among eukaryotes.
Pfam PF16773: Lactococcus phage single-stranded DNA binding protein (domain)
This single-stranded DNA binding protein is found in Lactococcus phage. It can stimulate RecA-mediated homologous recombination. Its structure is a variation of the typical oligonucleotide/oligosaccharide binding-fold of single-stranded DNA binding proteins.
Pfam PF02068: Plant PEC family metallothionein (domain)
Metallothioneins (MT) are small proteins that bind heavy metals, such as zinc, copper, cadmium, nickel, etc. They have a high content of cysteine residues that bind the metal ions through clusters of thiolate bonds . An empirical classification into three classes has been proposed by Fowler and coworkers  and Kojima . Members of class I are defined to include polypeptides related in the positions of their cysteines to equine MT-1B, and include mammalian MTs as well as MTs from crustaceans and molluscs. Class II groups MTs from a variety of species, including sea urchins, fungi, insects and cyanobacteria. Class III MTs are atypical polypeptides composed of gamma-glutamylcysteinyl units . This original classification system has been found to be limited, in the sense that it does not allow clear differentiation of patterns of structural similarities, either between or within classes. Consequently, all class I and class II MTs (the proteinaceous sequences) have now been grouped into families of phylogenetically-related and thus alignable sequences. This system subdivides the MT superfamily into families, subfamilies, subgroups, and isolated isoforms and alleles. The metallothionein superfamily comprises all polypeptides that resemble equine renal metallothionein in several respects : e.g., low molecular weight; high metal content; amino acid composition with high Cys and low aromatic residue content; unique sequence with characteristic distribution of cysteines, and spectroscopic manifestations indicative of metal thiolate clusters. A MT family subsumes MTs that share particular sequence-specific features and are thought to be evolutionarily related. The inclusion of a MT within a family presupposes that its amino acid sequence is alignable with that of all members. Fifteen MT families have been characterised, each family being identified by its number and its taxonomic range: e.g., Family 1: vertebrate MTs.

Family 15 consists of planta MTs. Its members are recognised by the sequence pattern [YFH]-x(5,25)-C-[SKD]-C-[GA]-[SDPAT]-x(0,1)-C-x-[CYF] which yields all plant sequences, but also MTCU_HELPO and the non-MT ITB3_HUMAN. The taxonomic range of the members extends to planta. Planta MTs are 45-84 residue proteins, containing 17 conserved cysteines that bind 5 zinc ions. Generally, there are two Cys-rich regions (domain 1 and domain 3) separated by a Cys-poor region (domain 2) and only the domain 2 contains unusual residues. It is believed that the proteins may have a role in Zn2+homeostasis during embryogenesis. Family 15 includes the following subfamilies: p1, p2, p2v, p3, pec, p21.
Pfam PF21666: Domain of unknown function DUF4246, N-terminal (domain)
This presumed domain is found N-terminal of [pfam:PF14033]) which may consist of four helices.
Pfam PF16341: Domain of unknown function (DUF4971) (family)
This small family consists of uncharacterised proteins around 370 residues in length and is mainly found in various Bacteroides species. The function of this protein is unknown.
Pfam PF24892: U3 small nucleolar RNA-associated protein 6 C-terminal (repeat)
U3 small nucleolar RNA-associated protein 6 (UTP6) is a component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA. These proteins consist of TPRs; this entry represents the C-terminal region of UTP6 from animals.
Pfam PF24895: Nonribosomal peptide synthetase sidD N-terminal (domain)
This entry represents the N-terminal domain of SIDD (Nonribosomal peptide synthetase sidD) from Aspergillus fumigatus and related fungal sequences. SIDD is part of the siderophore biosynthetic pathway.
Pfam PF04255: Protein of unknown function (DUF433) (domain)
This entry includes a group of uncharacterised proteins, including VapB45 from Mycobacterium tuberculosis. VapB45 is possibly the antitoxin component of a type II toxin-antitoxin (TA) module. Its cognate toxin is VapC45 .
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF11544: Spindle pole body component Spc42p (coiled_coil)
Spc42p is a 42-kD component of the S.cerevisiae spindle body that localises to the electron dense central region of the SPB.Spc42p is a phosphoprotein which forms a polymeric layer at the periphery of the SPB central plaque. This functions during SPB duplication and also facilitates the attachment of the SPB to the nuclear membrane.
Pfam PF09435: Fungal protein of unknown function (DUF2015) (family)
This is a fungal family of uncharacterised proteins.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF18853: Large polyvalent protein associated domain 37 (domain)
This is and alpha and beta fold domain that is found in polyvalent proteins that are likely to be phage/prophage-derived.
Pfam PF05837: Centromere protein H (CENP-H) (domain)
This family consists of several eukaryotic centromere protein H (CENP-H) sequences. Macromolecular centromere-kinetochore complex plays a critical role in sister chromatid separation, but its complete protein composition as well as its precise dynamic function during mitosis has not yet been clearly determined. CENP-H contains a coiled-coil structure and a nuclear localisation signal. CENP-H is specifically and constitutively localised in kinetochores throughout the cell cycle. CENP-H may play a role in kinetochore organisation and function throughout the cell cycle. This the C-terminus of the region, which is conserved from fungi to humans.
Wikipedia: Centromere protein H is a protein that in humans is encoded by the CENPH gene. It is involved in the assembly of kinetochore proteins, mitotic progression and chromosome segregation.
Pfam PF00415: Regulator of chromosome condensation (RCC1) repeat (repeat)
The regulator of chromosome condensation (RCC1)  is a eukaryotic protein which binds to chromatin and interacts with ran, a nuclear GTP-binding protein IPR002041, to promote the loss of bound GDP and the uptake of fresh GTP, thus acting as a guanine-nucleotide dissociation stimulator (GDS). The interaction of RCC1 with ran probably plays an important role in the regulation of gene expression.

RCC1, known as PRP20 or SRM1 in yeast, pim1 in fission yeast and BJ1 in Drosophila, is a protein that contains seven tandem repeats of a domain of about 50 to 60 amino acids. As shown in the following schematic representation, the repeats make up the major part of the length of the protein. Outside the repeat region, there is just a small N-terminal domain of about 40 to 50 residues and, in the Drosophila protein only, a C-terminal domain of about 130 residues.

+----+-------+-------+-------+-------+-------+-------+-------+-------------+
|N-t.|Rpt. 1 |Rpt. 2 |Rpt. 3 |Rpt. 4 |Rpt. 5 |Rpt. 6 |Rpt. 7 | C-terminal  |
+----+-------+-------+-------+-------+-------+-------+-------+-------------+

The RCC1-type of repeat is also found in the X-linked retinitis pigmentosa GTPase regulator . The RCC repeats form a Î²-propeller structure.
Pfam PF04355: Outer membrane protein assembly factor BamE domain (domain)
This domain is found in bacterial outer membrane lipoproteins probably involved in maintaining the structural integrity of the cell envelope, including Outer membrane protein assembly factor BamE from Vibrio cholerae (also known as SmpA). The lipid attachment site is a conserved N terminal cysteine residue. Sometimes found adjacent to the OmpA domain ([pfam:PF00691]).
Pfam PF18854: Bacterial archaeo-eukaryotic release factor family 10 (family)
Bacterial family of the archaeo-eukaryotic release factor superfamily. Likely to play roles in biological conflicts or regulation under stress conditions at the ribosome.
Pfam PF04660: Nanovirus coat protein (family)
Family of conserved Nanoviral coat proteins.
Pfam PF07426: Dynactin subunit p22 (family)
This family contains p22, the smallest subunit of dynactin, a complex that binds to cytoplasmic dynein and is a required activator for cytoplasmic dynein-mediated vesicular transport. Dynactin localises to the cleavage furrow and to the midbodies of dividing cells, suggesting that it may function in cytokinesis. Family members are approximately 170 residues long.
Wikipedia: Dynactin is a 23 subunit protein complex that acts as a co-factor for the microtubule motor cytoplasmic dynein-1. It is built around a short filament of actin related protein-1 (Arp1).
Pfam PF02777: Iron/manganese superoxide dismutases, C-terminal domain (domain)
superoxide dismutases (SODs) catalyse the conversion of superoxide radicals to hydrogen peroxide and molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the Mn/Fe-binding  family is one. In humans, there is a cytoplasmic Cu/Zn SOD, and a mitochondrial Mn/Fe SOD. C-terminal domain is a mixed alpha/beta fold.
Wikipedia: Superoxide dismutase (SOD, EC 1.15.1.1) is an enzyme that alternately catalyzes the dismutation (or partitioning) of the superoxide (O−2) anion radical into normal molecular oxygen (O2) and hydrogen peroxide (H2O2). Superoxide is produced as a by-product of oxygen metabolism and, if not regulated, causes many types of cell damage. Hydrogen peroxide is also damaging and is degraded by other enzymes such as catalase. Thus, SOD is an important antioxidant defense in nearly all living cells exposed to oxygen. One exception is Lactobacillus plantarum and related lactobacilli, which use intracellular manganese to prevent damage from reactive O−2.
Pfam PF04096: Nup98-96 autopeptidase S59 (domain)
The nuclear pore complex protein plays a role in bidirectional transport across the nucleoporin complex in nucleocytoplasmic transport. The mammalian nuclear pore complex (NPC) is comprised of approximately 30 unique proteins, collectively known as nucleoporins. This entry includes yeast family members such as Nup145p as well as vertebrate Nup98. The NUP C-terminal domains of Nup98 and Nup145 possess peptidase S59 autoproteolytic activity. The autoproteolytic sites of Nup98 and Nup145 each occur immediately C-terminal to the NUP C-terminal domain. Thus, although this domain occurs in the middle of each precursor polypeptide, it winds up at the C-terminal end of the N-terminal cleavage product. Cleavage of the peptide chains are necessary for the proper targeting to the nuclear pore.
Pfam PF10840: Protein of unknown function (DUF2645) (family)
This family of proteins appear to be restricted to Enterobacteriaceae. Some members in the family are annotated as YjeO however no function for this protein is currently known.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF02734: DAK2 domain (family)
This domain is the predicted phosphatase domain of the dihydroxyacetone kinase family.
Pfam PF22915: Armadillo-like helical domain-containing protein 5 (domain)
This domain represents a conserved set of armadillo-like repeats, whose function is not clear..
Pfam PF10906: MIOREX complex component 7 (family)
This entry includes budding yeast MIOREX complex component 7 (Mrx7), which associates with mitochondrial ribosome. Its function is not clear.
Pfam PF21263: Acyl-CoA dehydrogenase, C-terminal domain (domain)
This is an all-alpha up-and-down bundle found in acyl-CoA dehydrogenases, such as [swissprot:O32176] from Bacillus subtilis.
Pfam PF20572: Family of unknown function (DUF6781) (family)
This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 223 and 298 amino acids in length.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF07541: Eukaryotic translation initiation factor 2 alpha subunit (family)
These proteins share a region of similarity that falls towards the C terminus from [pfam:PF00575].
Pfam PF09502: Bacterial type III secretion protein (HrpB4) (family)
This entry represents proteins encoded by genes which are found in type III secretion operons in a narrow range of species including Xanthomonas, Burkholderia and Ralstonia.
Pfam PF20029: Domain of unknown function (DUF6436) (domain)
This domain of unknown function is found in uncharacterised bacterial proteins. This domain is about 60 amino acids in length and contains the conserved motifs GPY, GxxC and GCxC. These conserved cysteine residues and the fact that this domain has overlaps with families in clan CL0172 suggest that it is related to thioredoxins and it is likely in thiol-disulfide isomerases.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF06319: DNA repair protein MmcB-like (family)
This family includes Caulobacter MmcB (CCNA_03580), which is involved in DNA repair. It has been proposed to be an endonuclease that creates the substrate for translesion synthesis.
Pfam PF02376: CUT domain (domain)
The CUT domain is a DNA-binding motif which can bind independently or in cooperation with the homeodomain, often found downstream of the CUT domain. Multiple copies of the CUT domain can exist in one protein (eg [swissprot:P10180]).
Wikipedia: In molecular biology, the CUT domain is a DNA-binding motif which can bind independently or in cooperation with the homeodomain, which is often found downstream of the CUT domain. Proteins display two modes of DNA binding, which hinge on the homeodomain and on the linker that separates it from the CUT domain, and two modes of transcriptional stimulation, which hinge on the homeodomain.
Pfam PF04221: RelB antitoxin (domain)
RelE and RelB form a toxin-antitoxin system. RelE represses translation, probably through binding ribosomes (,). RelB stably binds RelE, presumably deactivating it.
Pfam PF10026: Predicted Zn-dependent protease (DUF2268) (family)
This domain, found in various hypothetical bacterial proteins, as well as predicted zinc dependent proteases, has no known function.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF02784: Pyridoxal-dependent decarboxylase, pyridoxal binding domain (domain)
These pyridoxal-dependent decarboxylases acting on ornithine, lysine, arginine and related substrates This domain has a TIM barrel fold.
Wikipedia: In molecular biology, group IV pyridoxal-dependent decarboxylases are a family of enzymes comprising ornithine decarboxylase EC 4.1.1.17, lysine decarboxylase EC 4.1.1.18, arginine decarboxylase EC 4.1.1.19 and diaminopimelate decarboxylaseEC 4.1.1.20. It is also known as the Orn/Lys/Arg decarboxylase class-II family.
Pfam PF19013: Family of unknown function (DUF5742) (family)
A highly conserved domain of unknown function found in various Platyhelminthes.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF14411: A nuclease of the HNH/ENDO VII superfamily with conserved LHH (family)
LHH is a predicted nuclease of the HNH/ENDO VII superfamily of the  treble clef fold. The name is derived from the conserved motif, LHH. It is found in bacterial polymorphic toxin systems and functions as a toxin module. Like WHH and AHH, LHH nuclease contain 4 conserved  histidines of which, the first one is predicted to bind metal-ion  and other three ones are involved in activation of water molecule for hydrolysis.
Pfam PF18213: SUB1 protease Prodomain ProdP9 (domain)
This domain is the bound prodomain fragment ProdP9 of the SUB1 protein present in Plasmodium falciparum.  SUB1 is a serine protease that processes a subset of parasite proteins that play indispensable roles in egress and invasion. The C-terminal stalk of ProdP9 binds in the active site groove in a substrate-like manner and is truncated at the N terminus as a result of the chymotrypsin digestion step used during purification. ProdP9 is structural similar to MIC5 from Toxoplasma gondii, despite low sequence identity.
Pfam PF22346: ADP-ribosylating toxin CARDS, C-terminal beta-trefoil domain (domain)
This domain is found at the C-terminal end of ADP-ribosylating toxin CARDS from Mycoplasma pneumoniae, the main virulence factor for this bacteria. CARDS (for Community-Acquired Respiratory Distress Syndrome Toxin) is organised into three domains, an N-terminal [pfam:PF02917] and tandem C-terminal beta -trefoil domain. This entry represents the last domain (named D3).
Pfam PF20136: Family of unknown function (DUF6526) (family)
This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 140 amino acids in length.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF23549: GRF-like zinc ribbon domain (domain)
This domain is found in a group of uncharacterised proteins mainly from Fungi. It is predicted to adopt a zinc ribbon fold and it is closely related to GRF type zinc fingers ([pfam:PF06839]).
Pfam PF19242: Putative zinc finger protein (family)
This is a family of proteins predominantly found in Iridoviridae, which contains a zinc finger domain.