SII-SWORD/CoKE huggingface dataset:
Pfam PF13311: Protein of unknown function (DUF4080) (family)
A family of uncharacterized proteins found by clustering  human gut metagenomic sequences.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF20926: Huntingtin, N-terminal HEAT 1 (repeat)
This entry represents the first region of HEAT repeats from Huntingtin (Htt), which is part of the N-terminal HEAT domain. It is separated from the rest of the domain ([pfam:PF12372]) by an unstructured region. Htt is expressed in many tissues with various expression levels and is involved in a number of cellular functions. However, its exact function is not yet clear. An abnormal polyglutamine (polyQ) expansion between 1-90aa at the very N-terminal causes Huntington's disease (HD), a progressive autosomal-dominant neurodegenerative disease characterised by an uncontrolled motor movement known as chorea, cognitive disorder and depression. Htt consists of multiple HEAT repeats organised in N-terminal, bridge and C-terminal domains, which function as a scaffold that mediated interactions with binding partners.
Pfam PF00137: ATP synthase subunit C (domain)
This domain is found in the subunit c of ATP synthases and similar sequences from all cellular organisms. It forms two alpha-helices.
Wikipedia: ATPase, subunit C of Fo/Vo complex is the main transmembrane subunit of V-type, A-type and F-type ATP synthases. Subunit C was found in the Fo or Vo complex of F- and V-ATPases, respectively. The subunits form an oligomeric c ring that make up the Fo/Vo/Ao rotor, where the actual number of subunits vary greatly among specific enzymes.
Pfam PF12675: Protein of unknown function (DUF3795) (family)
This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and archaea. Proteins in this family are typically between 99 and 171 amino acids in length. This protein is likely to be zinc binding given the conserved cysteines.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF13887: Myelin regulatory factor ICA domain (domain)
This domain corresponds to the Intramolecular Chaperone Auto-processing (ICA) domain of myelin regulatory factor (Myrf) located at its C-terminal and belongs to the Peptidase S74 family. It forms a homo-trimer and carries out the auto-cleavage of Myrf releasing the Myrf N-terminal homo-trimer from the ER membrane. This allows its entry to the nucleus to function as a homo-trimer transcription factor.
Pfam PF23493: Cysteinyl-tRNA ligase anticodon binding domain (domain)
This entry represents the C-terminal anticodon binding domain from Cysteinyl-tRNA ligase.  The entry also includes the C-terminal domain of YqeB from B.  subtilis. These proteins contain 2 transmembrane helices and a bacterial PH domain.
Pfam PF04814: Hepatocyte nuclear factor 1 (HNF-1), N terminus (family)
This family consists of the N terminus of homeobox-containing transcription factor HNF-1.  This region contains a dimerisation sequence and an  acidic region that may be involved in transcription activation. Mutations and the common Ala/Val 98 polymorphism in HNF-1 cause the type 3 form of maturity-onset diabetes of the young (MODY3).
Pfam PF18052: Rx N-terminal domain (domain)
This entry represents the N-terminal domain found in many plant resistance proteins. This domain has been predicted to be a coiled-coil, however the structure shows that it adopts a four helical bundle fold.
Pfam PF20839: Family of unknown function (DUF5382) C-terminal domain (domain)
This is a domain of unknown function found in Caenorhabditis. It has an NTF2-like fold.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF22016: Domain of unknown function (DUF6933) (domain)
This domain is found in bacterial and archaeal uncharacterised proteins. It is typically between 150 and 160 amino acids in length. It is remotely related to ribonuclease H-like nucleases but it is unlikely to possess any enzymatic activity.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF07400: Interleukin 11 (domain)
This family contains interleukin 11 (approximately 200 residues long). This is a secreted protein that stimulates megakaryocytopoiesis, resulting in increased production of platelets, as well as activating osteoclasts, inhibiting epithelial cell proliferation and apoptosis, and inhibiting macrophage mediator production. These functions may be particularly important in mediating the hematopoietic, osseous and mucosal protective effects of interleukin 11. Family members seem to be restricted to mammals.
Wikipedia: Interleukin 11 is a protein that in humans is encoded by the IL11 gene.
Pfam PF15219: Testis-expressed 12 (family)
TEX12 is a meiosis-specific protein . TEX12 contributes to the formation of the central element of the synaptonemal complex (SC) in mouse meiocytes .
Pfam PF18859: Actinobacteria/chloroflexi VLRF1 release factor (family)
Archaeo-eukaryotic release factor domain family belonging to the VLRF1 clade, observed primarily in the actinbacteria and chloroflexi bacterial lineages. Contains a conserved glutamine residue in the release factor catalytic loop, suggesting it functions as an active peptidyl-tRNA hydrolase at the ribosome.
Pfam PF10884: Protein of unknown function (DUF2683) (family)
This family of proteins with unknown function appears to be restricted to Methanosarcinaceae.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF20108: Family of unknown function (DUF6498) (family)
This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 229 and 247 amino acids in length.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF01684: ET module (family)
This domain has no known function. It is found in several C. elegans proteins. The domain contains 8-10 conserved cysteines that probably form 4-5 disulphide bridges. By inspection of the conservation of cysteines it looks like cysteines 1,2,3,4,9 and 10 are always present and that sometimes the pair 5 and 8 or the pair 6 and 7 are missing. This suggests that cysteines 5/8 and 6/7 make disulphide bridges.
Pfam PF20423: Isocitrate dehydrogenase kinase/phosphatase (AceK), regulatory domain (domain)
This is the N-terminal regulatory domain of bacterial isocitrate dehydrogenase kinase/phosphatase (AceK) proteins ([ec:2.7.1.116]). It has an alpha-helical fold, with two long, parallel alpha-helices that form a large hairpin structure followed by two short, parallel alpha-helices forming a small hairpin segment. This domain is linked to the C-terminal kinase domain by a short (27 residues) alpha-helix.
Pfam PF14883: Hypothetical glycosyl hydrolase family 13 (family)
GHL13 is a family of hypothetical glycoside hydrolases.
Pfam PF03489: Saposin-like type B, region 2 (family)
Saposin B is a small non-enzymatic glycoprotein required for the breakdown of cerebroside sulphates (sulphatides) in lysosomes. Saposin B contains three intramolecular disulphide bridges, exists as a dimer and is remarkably heat, protease and pH stable. The crystal structure of human saposin B reveals an unusual shell-like dimer consisting of a monolayer of alpha-helices enclosing a large hydrophobic cavity. It is one of the most studied members of the saposin protein family and it is involved in the hydrolysis of glycolipids and glycerolipids. SapB is unique in the saposin family in that it facilitates degradation by interacting with the substrate, not the enzymes.
Wikipedia: The saposin domains refers to two evolutionally-conserved protein domains found in saposin and related proteins (SAPLIP). Saposins are small lysosomal proteins that serve as activators of various lysosomal lipid-degrading enzymes. They probably act by isolating the lipid substrate from the membrane surroundings, thus making it more accessible to the soluble degradative enzymes. All mammalian saposins are synthesized as a single precursor molecule (prosaposin) which contains four Saposin-B domains, yielding the active saposins after proteolytic cleavage, and two Saposin-A domains that are removed in the activation reaction.
Pfam PF10777: Inner membrane protein YlaC (domain)
Members of this family include proteins annotated as inner membrane protein YlaC in E. coli and Salmonella. The function of this family is unknown.
Pfam PF22717: Short NACHT-associated C-Terminal domain, family 10 (domain)
The SNaCT domains are a rapidly evolving, monophyletic assemblage of domains found C-terminal to the NACHT module in several bacterial NACHT conflict systems. They contain a well-conserved aspartate near the N-terminus of the domain. SNaCT domains are thought to occlude the NTP-binding region, potentially until they interact with phage-encoded bNACHT inhibitors.
Pfam PF23743: BBS7 beta-propeller (repeat)
BBS7 is one of seven proteins that form the BBSome complex, localised at ciliary bases in the cytoplasm. The BBS7 beta-propeller interacts with the beta-propeller domain of another BBSome protein, BBS1, in order to control access of the membrane-recruiting protein ARL6. Mutations on or lack of BB7 (or any BBSome protein) causes Bardet-Biedl syndrome (BBS), characterized by cilium dysfunction.
Pfam PF15365: Proline-rich nuclear receptor coactivator motif (conserved_site)
The PNRC family, proline-rich nuclear receptor coactivator, is found in eukaryotes.  Studies in S. pombe show that the proteins carrying this motif are mRNA decapping proteins. In addition, this motif is found in Saccharomyces cerevisiae two intrinsically disordered decapping enhancers Edc1 and Edc2, which show limited sequence conservation with human PNRC2. This motif in the N-terminal domain serves two purposes: it enhances the activity of the catalytic domain by recognizing part of the mRNA cap structure (i.e. activation motif) , and secondly, it directly interacts with the decapping activator Dcp1. Mutation in the (YAG) sequence led to los of activity of activate the decapping complex. Hence the activity of the family members involved in mRNA processing mechanisms depends on YAG activation motif that is 11-13 residues N-terminal of a conserved LPxP Dcp1 interaction motif.
Pfam PF17555: Type VI secretion system, TssN (family)
T6SSs are toxin delivery systems. It is a multiprotein complex requiring numerous core proteins (Tss proteins) including cytoplasmic, transmembrane, and outer membrane components. The needle or tube apparatus is comprised of a phage-like complex, similar to the T4 contractile bacteriophage tail, which is thought to be anchored to the membrane by a trans-envelope complex. TssN proteins have multiple predicted transmembrane (TM) regions. In Flavobacterium johnsoniae, three specific components (TssN, TssO and TssP) are absent in the other sub-types of T6SS.
Pfam PF16423: Transcription factor COE1 helix-loop-helix domain (domain)
This is the helix-loop-helix domain of transcription factor COE1. It is responsible for dimerisation.
Wikipedia: Transcription factor COE1 is a protein that in humans is encoded by the EBF1 gene. 
EBF1 stands for Early B-Cell Factor 1.
Pfam PF16933: Putative exopolysaccharide Exporter (EPS-E) (family)
PelG is a family of putative exopolysaccharide transporters like PelG.  Most members carry twelve transmembrane regions. The family also contains fusion proteins with glycosyl transferase group 1, which are putative flippase transporters.
Pfam PF18217: Zap1 zinc finger 2 (domain)
This domain can be found in Zap1 present in Saccharomyces cerevisiae. Zap1 regulates S. cerevisiae which mediates the transcription of genes encoding uptake vacuolar transporters. This domain corresponds to zinc finger 2 (zf2) which has been shown to be a constitutive transcriptional activator. The two zinc fingers interactions stabilizes Zn(II)-binding.
Pfam PF18363: Phosphoinositide phosphatase insertion domain (domain)
This domain is found in the effector protein SidP present in Legionella longbeachae. SidP functions as a Phosphoinositide-3-phosphatase specifically hydrolyzing Phosphoinositide(3)P, referred to as PI(3)P, and PI(3,5)P2. The domain is inserted into the N-terminal portion of the catalytic domain and is referred to as the appendage or insertion (I) domain.
Pfam PF22925: Trans-sialidase, C-terminal domain (domain)
This domain is found C-terminal in a number of Trans-sialidases (TS) from Trypanosoma cruzi and other related species. The Trypanosoma TS is involved in host cell invasion and parasite survival in the bloodstream. The parasite uses TS activity to sialylate its own surface molecules, allowing it to evade lysis by serum factors. This domain follows the catalytic domain and adopts a beta-sandwich fold typical for Concanavalin-like lectin/glucanase superfamily. It is likely involved in binding glycan structures present on the surface of the Trypanosomes or host cells and in modulating the activity and biological function of TS.
Pfam PF23511: Apicomplexa microprotein (family)
This protein family includes uncharacterised microproteins encoded by small open reading frames (smORFs) from apicomplexa, including [swissprot:A7AQZ1] from the parasite Babesia bovis.
Pfam PF22007: Domain of unknown function (DUF6930) (domain)
This domain is found C-terminal in uncharacterised bacterial proteins. It is remotely related to the integrase core domain with a partly conserved active site architecture.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF07046: Cytoplasmic repetitive antigen (CRA) like repeat (coiled_coil)
This family consists of several repeats of around 42 residues in length. These repeated sequences are found in multiple copies in Trypanosoma cruzi antigens, [swissprot:Q26907] contains 23 copies of this repeat.
Pfam PF22239: Domain of unknown function (DUF6947) (domain)
This is a domain found in a group of uncharacterised bacterial sequences whose function is unknown. This domain adopts a galactose-binding-like structure (PDBe:4lr4).
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF01055: Glycosyl hydrolases family 31 TIM-barrel domain (domain)
Glycosyl hydrolases are key enzymes of carbohydrate metabolism. Family 31 comprises of enzymes that are, or similar to, alpha- galactosidases. This entry corresponds to the second domain of family 31 enzymes and adopts a TIM-barrel fold.
Wikipedia: In molecular biology, glycoside hydrolase family 31 is a family of glycoside hydrolases.
Pfam PF00557: Metallopeptidase family M24 (domain)
This family contains metallopeptidases.  It also contains non-peptidase homologues such as the N terminal domain of Spt16 which is a histone H3-H4 binding module.
Pfam PF21636: Protein phosphatase 1 regulatory subunit 21, C-terminal (coiled_coil)
Protein phosphatase 1 regulatory subunit 21 (PPP1R21) is a regulator of protein phosphatase 1 (PP1) activity and may play a role in the endosomal sorting process or in endosome maturation pathway. This entry represents the C-terminal coiled-coil which contains the characteristic TTKRSYEDQ sequence-motif found in coiled-coil proteins that are conserved from nematodes to humans.
Pfam PF21462: Ph 6 antigen (domain)
This entry represents the ph 6 antigen (also known as adhesin or antigen 4) from Yersinia pestis, which is part of fimbriae, necessary for full virulence. It mediates bacterial attachment to alveolar cells of the lung.
Pfam PF20804: Mastermind-like protein 2, transcriptional activation domain (domain)
Mastermind-like proteins (MAML1-3) were first described as transcriptional co-activators for Notch signalling but more recently they have been also implicated as transcriptional co-activators in other signal transduction pathways including muscle differentiation and myopathies, tumour suppressor pathway (p53) and colon carcinoma survival (beta-catenin). The N-terminal basic domain ([pfam:PF09596]) of MAML1-3 is the most conserved region of this proteins, outside this region their sequences are quite divergent. However, they all have transactivation domains (TADs) at the C-terminal end, suggesting different functions among them as they cooperate differentially with various Notch receptors in the activation of target genes. Recently, MAML1 and MAML2 have been identified as transcriptional coactivators of the Hippo pathway. A structural feature of the MAML family is the presence of polyglutamine (polyQ) tracts, which, in some polyQ proteins, expansion of this tracts cause protein inestability and the formation of nuclear inclusions in neurons, leading to neurotoxicity. This entry represents the TAD domain from MAML2.
Pfam PF15967: Nucleoporin FG repeated region (family)
Nucleoporin_FG2, or nucleoporin p58/p45, is a family of chordate nucleoporins. The proteins carry many repeats of the FG sequence motif.
Pfam PF11486: Protein of unknown function (DUF3212) (family)
Members in this family of proteins are annotated as YfmB however currently no function for this protein is known.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF07591: Pretoxin HINT domain (family)
A member of the HINT superfamily of proteases that is usually found N-terminal to the toxin module in polymorphic toxin systems. The  domain is predicted to function in releasing the toxin domain by  autoproteolysis.
Pfam PF20520: V0 complex accessory subunit Ac45/VOA1 transmembrane domain (domain)
This entry represents the transmembrane domain from ER/Golgi membrane proteins including V0 complex accessory subunit Ac45 (ATP6AP1, also known as V-type proton ATPase subunit S1) from animals and the yeast homologue V0 assembly protein 1 (VOA1) which are essential for V0 ATPase assembly, stability and function. In humans, mutations of ATP6AP1 cause immunodeficiency with hypogammaglobulinemia, hepatopathy and neurocognitive abnormalities. This entry also includes ER membrane BIG1 proteins from yeast, involved in cell wall biogenesis.
Pfam PF17949: FANCM pseudonuclease domain (domain)
This entry represents the pseudonuclease domain (PND) from the FANCM protein. This domain is part of the PD(D/E)XK superfamily but does not appear to have a full set of catalytic residues.
Pfam PF15606: Bacterial toxin 34 (family)
A predicted RNase toxin found in bacterial polymorphic toxin systems.  The toxin possesses an all-alpha helical fold and conserved lysine and cysteine residues, and GNxxD and WxCxH motifs. In bacterial polymorphic toxin systems, the toxin is exported by the type 2 or type 6 secretion system.
Pfam PF23796: Family of unknown function (DUF7174) (family)
This protein is found in caudoviruses, which are tailed bacteriophages. The protein is typically around 150-180 amino acids in length. Its function is currently unknown.  It is found in viruses from the Drexlerviridae family, including Rogunavirinae, Braunvirinae, Tempevirinae, and Kyungwonvirus genera.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF24681: KLHDC2/KLHL20/DRC7 Kelch-repeats domain (repeat)
This entry represents a Kelch-repeats-like domain found in a diverse group of proteins, including KLHDC2, Kelch-like protein 20 and FBX42 from human, which are the substrate-recognition component of E3 ubiquitin-protein ligase complexes. KLHDC2 is the substrate-recognition component of Cul2-RING (CRL2) E3 ubiquitin-protein ligase complex of the DesCEND (destruction via C-end degrons) pathway, which recognises a C-degron located at the extreme C-terminus of target proteins, leading to their ubiquitination and degradation. KLHL20 and its orthologue from Drosophila diablo, are the substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex, involved in interferon response and anterograde Golgi to endosome transport. This domain can be found in DRC7 from C. reinhardtii and related sequences.
Pfam PF08532: Beta-galactosidase trimerisation domain (domain)
This is non catalytic domain B of beta-galactosidase enzymes belong to the glycosyl hydrolase 42 family. This domain is related to glutamine amidotransferase enzymes, but the catalytic residues are replaced by non functional amino acids. This domain is involved in trimerisation.
Wikipedia: In molecular biology, glycoside hydrolase family 42 is a family of glycoside hydrolases.