SII-SWORD/CoKE huggingface dataset:
Pfam PF22264: Family of unknown function (DUF6952) (family)
This is a family of uncharacterised bacterial proteins. They contain highly conserved acidic residues and G[S/A]ID motif at the C terminus.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF20757: Protein M, large region (domain)
This domain is found in proteins from Mycoplasmaceae, including Uncharacterized protein MG281 from Mycoplasma genitalium, also known as protein M. This virulence protein consists of two domains. The larger one (this entry) binds the IgG light chain to block the binding of antibody to antigen. It includes a leucine-rich repeat (LRR)-like subdomain, which faces away from the antibody molecule.
Pfam PF24178: Lasso peptide subterisin (family)
This entry represents the lasso peptide subterisin and related peptides from proteobacteria. Lasso peptides are a class of ribosomally biosynthesised and post-translationally modified peptides (RiPPs) with common motif of a knot structure in the molecule. The amino group of N-terminal amino acid forms an isopeptide bond with beta- or gamma- carboxyl group of Asp or Glu located near the N-terminus, resulting in formation of a macrolactam ring. The macrolactam ring looks like a loop of a "lasso" with a tail of the C-terminal linear peptide that normally locates through the ring PDB:5XM4.
Pfam PF07254: Membrane-bound toxin component of toxin-antitoxin system (family)
CptA is a family of bacterial proteins named for the member of this family, YGFX_ECOLI, Swissprot:Q46824. YgfX was previously thought to be the toxic part of a toxin-antitoxin module along with the antitoxin, [pfam:PF03937] Sdh5. However, studies have shown that, YgfX interferes with correct cell division and morphology. Furthermore, the function of YgfX-SdhE as a TA system could not be demonstrated in either E. coli or Serratia sp. ATCC 39006. YgfX is predicted to have a short N-terminal cytoplasmic domain followed by two transmembrane helices (TMHs) separated by a short periplasmic loop and finally, a larger C-terminal cytoplasmic domain. The TMHs of YgfX are required for activity, but the sequence of the cytoplasmic 13 N-terminal amino acids is not essential. Furthermore, the amino acids W34 and D117 are not required for localization but are necessary for YgfX multimerization, interaction with SdhE, and YgfX activity. It is proposed that the formation of YgfX multimeric membrane-bound proteins are required to enable the interaction with the cytoplasmic SDH assembly factor SdhE. Another study has demonstrated that sdhEygfX (bicistronic operon) affects pig biosynthesis, directly or indirectly, at the level of transcription of the biosynthetic operon (pigA-O). It has also been suggested that, in addition to indirect transcriptional activation of pigA-O, YgfX might facilitate the formation of a terminal pig biosynthetic complex consisting of PigB and PigC.
Wikipedia: A toxin-antitoxin system consists of a "toxin" and a corresponding "antitoxin", usually encoded by closely linked genes. The toxin is usually a protein while the antitoxin can be a protein or an RNA. Toxin-antitoxin systems are widely distributed in prokaryotes, and organisms often have them in multiple copies. When these systems are contained on plasmids – transferable genetic elements – they ensure that only the daughter cells that inherit the plasmid survive after cell division. If the plasmid is absent in a daughter cell, the unstable antitoxin is degraded and the stable toxic protein kills the new cell; this is known as 'post-segregational killing' (PSK).
Pfam PF19534: Family of unknown function (DUF6059) (family)
This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0001922) is described by MIBiG as an example of the following biosynthetic class, polyketide. This family includes a  protein from the isoindolinomycin biosynthetic gene cluster from  Streptomyces sp. SoC090715LN-16 and appears to be predominantly found in Actinobacteria.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF02063: MARCKS family (family)
Myristoylated alanine-rich C-kinase substrate (MARCKS) is a predominent cellular substrate for protein kinase C (PKC) that has been implicated in the regulation of brain development, macrophage activation, neuro-secretion and growth factor-dependent mitogenesis . The N-terminal glycine is the site of myristoylation, which allows effective binding of the protein to the plasma membrane, where it co-localises with PKC . MARCKS binds calmodulin in a calcium-dependent manner; the region responsible for calcium-binding is highly basic, a domain of about 25 amino acids known as the PSD or effector domain, which also contains the PKC phosphorylation sites and has been shown to contribute to membrane binding. When not phosphorylated, the effector domain can bind to filamentous actin . It is believed that MARCKS may be a regulated crossbridge between actin and the plasma membrane; modulation of the actin cross-linking activity by calmodulin and phosphorylation, represent a potential convergence of the calcium-calmodulin and PKC signal transduction pathways in regulation of the actin cytoskeleton. MARCKS also contains an MH2 domain of unknown function.

MARCKS-related protein (MRP) is similar to MARCKS in terms of properties such as its myristoylation, phosphorylation and calmodulin-binding, and shares a high degree of sequence similarity. The two regions that show the highest similarity are the kinase C phosphorylation site domain and the N-terminal region containing the myristoylation site . MARCKS and MRP amino acid compositions are similar, but the alanine content of the latter is lower. MARCKS proteins appear to adopt a native unfolded conformation i.e. as randomly folded chains arranged in non-classical extended conformations, in common with other substrates of PKC.
Pfam PF01058: NADH ubiquinone oxidoreductase, 20 Kd subunit (domain)
This entry represents a Rossmann fold-type domain found in NADH:ubiquinone oxidoreductase 20kDa subunit, [NiFe] hydrogenase small subunit and coenzyme F420 hydrogenase subunit gamma.

NADH:ubiquinone oxidoreductase (complex I) (1.6.5.3) is a respiratory-chain enzyme that catalyses the transfer of two electrons from NADH to ubiquinone in a reaction that is associated with proton translocation across the membrane (NADH + ubiquinone = NAD+ + ubiquinol) . Among the many polypeptide subunits that make up complex I, there is one with a molecular weight of 20kDa (in mammals) , which is a component of the iron-sulphur (IP) fragment of the enzyme. It seems to bind a 4Fe-4S iron-sulphur cluster.

The great majority of hydrogenases (H2ases) contain iron-sulfur clusters and two metal atoms at their active centre, Ni and Fe in the case of the [NiFe]-H2ases. They catalyse the reversible oxidation of hydrogen gas and play a central role in microbial energy metabolism; in addition to their role in fermentation and H2 respiration . The small subunit (chain A) contains the Fe4S4 clusters, whereas the large subunit (chain B) binds the binuclear NiFe active site .
Wikipedia: Respiratory complex I, EC 7.1.1.2 is the first large protein complex of the respiratory chains of many organisms from bacteria to humans. It catalyzes the transfer of electrons from NADH to coenzyme Q10 (CoQ10) and translocates protons across the inner mitochondrial membrane in eukaryotes or the plasma membrane of bacteria.
Pfam PF16956: Putative general bacterial porin (family)
This entry represent a group of putative general bacterial porins.
Pfam PF22731: NACHT C-terminal Helical domain 4 (domain)
This is a helical domain found at the C-terminus of bacterial NACHT conflict systems.
Pfam PF09886: Uncharacterized protein conserved in archaea (DUF2113) (family)
This domain, found in various hypothetical archaeal proteins, has no known function.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF04718: Mitochondrial ATP synthase g subunit (family)
The Fo sector of the ATP synthase is a membrane bound complex which mediates proton transport.  It is composed of nine different polypeptide subunits (a, b, c, d, e, f, g F6, A6L). The function of subunit g is currently unknown.  The conserved region covers all but the very N-terminus of the member sequences. No prokaryotic members have been identified thus far.
Wikipedia: ATP synthase subunit g, mitochondrial is an enzyme that in humans is encoded by the ATP5MG gene.
Pfam PF01939: Endonuclease NucS C-terminal domain (domain)
Endonuclease NucS cleaves both 3' and 5' ssDNA extremities of branched DNA structures and it binds to ssDNA. This entry represents the C-terminal domain of NucS.
Pfam PF16001: Domain of unknown function (DUF4775) (family)
This family of proteins is functionally uncharacterised. This family of proteins is found in eukaryotes. Proteins in this family are typically between 308 and 484 amino acids in length.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF12613: Flagellin, D2 domain (domain)
This variable D2 domain is found in uncharacterised proteins from Betaproteobacteria, including Flagellin from Burkholderia pseudomallei (FliC). FliC assembles to form the flagellar filament that supports bacterial motility. The family is found in association with [pfam:PF00669], [pfam:PF00700].
Pfam PF18126: Mitochondrial ribosomal protein mL59 (domain)
This domain is a protein found in mitochondrial ribosome 54S large sub unit present in species such as Saccharomyces cerevisiae. The domain used to be referred to as MRP25 but is now called mL59 protein. mL59 is known to partially stabilize a change in the rRNA path prior to helix 82-ES1 ultimately leading to the stabilization of the phosphate backbone of the tRNA acceptor stem. It is worth noting that the domain is encoded in the nucleus and imported from the cytoplasm.
Pfam PF24995: dsRNA binding domain (domain)
This entry represents a a set of divergent dsRNA binding domains.
Pfam PF06251: Capsule biosynthesis GfcC C-terminal (domain)
Many bacteria are covered in a layer of surface-associated polysaccharide called the capsule. These capsules can be divided into four groups depending upon the organisation of genes responsible for capsule assembly, the assembly pathway and regulation.  This family plays a role in group 4 capsule biosynthesis.  These proteins have a beta-grasp fold. Two beta-grasp domains, D2 and D3, are arranged in tandem. There is a C-terminal amphipathic helix which packs against D3. A helical hairpin insert in D2 binds to D3 and constrains its position, a conserved arginine residue at the end of this hairpin is essential for structural integrity. This is the C-terminal domain which covers D3 and D4 domains.
Pfam PF01924: Hydrogenase formation hypA family (family)
HypD is involved in hydrogenase formation. It contains many possible metal binding residues, which may bind to nickel. Transposon Tn5 insertions into hypD resulted in R. leguminosarum mutants that lacked any hydrogenase activity in symbiosis with peas.
Pfam PF02816: Alpha-kinase family (family)
This family is a novel family of eukaryotic protein kinase catalytic  domains, which have no detectable similarity to conventional kinases. The family contains myosin heavy chain kinases and Elongation Factor-2 kinase and a bifunctional ion channel. This family is known as the alpha-kinase family. The structure of the kinase domain revealed unexpected similarity to eukaryotic protein kinases in the catalytic core as well as to metabolic enzymes with ATP-grasp domains.
Pfam PF23409: Echinoderm microtubule-associated protein first beta-propeller (repeat)
This entry represents beta-propeller domains of echinoderm microtubule-associated protein (EMAP)-like (EML) proteins, a family of proteins that contribute to formation of the mitotic spindle and interphase microtubule network. In these proteins, the beta-propellers are intimately associated as a pair which was defined as tandem atypical propeller in EMLs (TAPE) domain. There is a hydrophobic core between the propellers which corresponds the HELP motif ([pfam:PF03451]) that contributes blades 1 and 14 buried at the interface and joints them. This model completes the first beta-propeller of the TAPE pair in EMLs. In some members, such as EML5 and EML6, there are three TAPE pairs.
Pfam PF12107: Plasminogen (Pg) ligand in fibrinolytic pathway (family)
Pg is an important mediator of angiostatin production in the fibrinolytic pathway. Pg is made up of five subunit kringle molecules (Pg-K1 to Pg-K5), of which the first three make the protein angiostatin. VEK-30 is a domain of the group A streptococcal protein PAM. It binds to Pg-K2 of angiostatin and activates the molecule to mediate its anti-angiogenic effects. VEK-30 binds to angiostatin via a C terminal lysine with argininyl and glutamyl side chain residues known as a 'through space isostere'.
Pfam PF08595: RXT2-like, N-terminal (family)
The family represents the N-terminal region of RXT2-like proteins.  In S. cerevisiae, RXT2 has been demonstrated to be involved in conjugation with cellular fusion (mating) and invasive growth.  A high throughput localisation study has localised RXT2 to the nucleus.
Pfam PF21048: Rad26-like, N-terminal domain (domain)
This domain is found at the N-terminal end of Rad26 from Myceliophthora thermophila ([swissprot:G2QDY6]), a functional subunit of the Rad3-Rad26 complex that is responsible for bringing the kinase to sites of DNA damage. This domain consists of two helices that are arranged perpendicular to each other with an extended loop region in between. This coiled-coil domain is well-conserved in Rad26 orthologues. It seems to play a role in the formation of dimers.
Pfam PF19102: Family of unknown function (DUF5789) (family)
This is a family of proteins of unknown function predominantly found in Halobacteria.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF24106: EDC4-like protein pdc1 beta-propeller (repeat)
This entry represents the beta-propeller domain of the enhancer of mRNA-decapping protein 4-like protein pdc1 from yeast. This protein is required for the assembly of processing bodies (P-bodies), cytoplasmic RNA granules where mRNA decay occurs. While evidence suggests pdc1 interacts with proteins Edc3 and Dcp2 through its terminal domains to achieve functional P-bodies, the function of this domain remains unknown. This entry also includes the beta-propeller domain of pdc1's paralogue, the uncharacterised protein YAG9 (or eti1) from yeast, which localises to P-bodies and interacts with exonuclease Exo2 but whose function remains unknown.
Pfam PF25117: Agd3 C-terminal domain (domain)
This entry represents the C-terminal domain of the exopolysaccharide deacetylase Agd3 from Aspergillus fumigatus, a protein required for biofilm formation. It forms six beta-strands in a seven-stranded beta-sandwich, whose function is unknown.
Pfam PF20111: Family of unknown function (DUF6501) (family)
This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 70 amino acids in length.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF00130: Phorbol esters/diacylglycerol binding domain (C1 domain) (domain)
This domain is also known as the Protein kinase C conserved region 1 (C1) domain.
Wikipedia: C1 domain binds an important secondary messenger diacylglycerol (DAG), as well as the analogous phorbol esters. Phorbol esters can directly stimulate protein kinase C, PKC.
Pfam PF13007: Transposase C of IS166 homeodomain (family)
This is a leucine-zipper-like or homeodomain-like region of transposase TnpC of insertion element IS66.
Pfam PF02975: Methylamine dehydrogenase, L chain (domain)
Aralkylamine dehydrogenase light chain and methylamine dehydrogenase light chain are aromatic amine dehydrogenases that form heterotetramers with their respective heavy chains, and catalyse the oxidative deamination of amines to their corresponding aldehydes.

This entry represents a conserved domain found towards the C terminus of these proteins.
Pfam PF07392: Cyclin-dependent kinase inhibitor 2a p19Arf N-terminus (family)
This family represents the N-terminus (approximately 50 residues) of  cyclin-dependent kinase inhibitor 2a p19Arf, which seems to be restricted to mammals. This is a tumour-suppressor protein that has been shown to inhibit the growth of human tumour cells lacking functional p53 by inducing a transient G2 arrest and subsequently apoptosis.
Wikipedia: p16, is a protein that slows cell division by slowing the progression of the cell cycle from the G1 phase to the S phase, thereby acting as a tumor suppressor. It is encoded by the CDKN2A gene. A deletion in this gene can result in insufficient or non-functional p16, accelerating the cell cycle and resulting in many types of cancer.
Pfam PF17642: Hemolysin coregulated protein Hcp (TssD) (family)
T6SSs are toxin delivery systems. It is a multiprotein complex requiring numerous core proteins (Tss proteins) including cytoplasmic, transmembrane, and outer membrane components. The needle or tube apparatus is comprised of a phage-like complex, similar to the T4 contractile bacteriophage tail, which is thought to be anchored to the membrane by a trans-envelope complex. These tube and trans-envelope sub-assemblies are linked via TssK. This entry comprises family members such as the inner tube protein Hcp (TssD). Hcp proteins form hexamers that stack to form the inner tube/needle structure of the puncturing device. Other functions have also been described for Hcp proteins, for example, some Hcp proteins have been shown to have a chaperone function in that they bind to and stabilize effectors. In addition, there are 'evolved' Hcp proteins that have the Hcp domain at the N-terminal half of the protein and a toxic effector function present in the C-terminal portion of the protein.
Pfam PF13232: Complex1_LYR-like (domain)
This is a family of proteins carrying the LYR motif of family Complex1_LYR, [pfam:PF05347], likely to be involved in Fe-S cluster biogenesis in mitochondria.
Pfam PF20703: Novel STAND NTPase 1 (domain)
This is a novel domain of the STAND-superfamily of AAA+ ATPases found in bacterial conflict systems.
Pfam PF12499: Pherophorin (family)
This domain family is found in eukaryotes, and is typically between 147 and 160 amino acids in length. The proteins in this family are frequently annotated as pherophorins however there is little accompanying literature to confirm this.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF08095: Hefutoxin family (family)
This family consists of the hefutoxins that are found  in the venom of the scorpion Heterometrus fulvipes.  These toxins, kappa-hefutoxin1 and kappa-hefutoxin2,  exhibit no homology to any known toxins. The hefutoxins  are potassium channel toxins.
Pfam PF12064: Protein kinase C-binding protein 1 (family)
This is a domain found predominantly in eukaryotes and associated with [pfam:PF00628] [pfam:PF01753] [pfam:PF00439] [pfam:PF00855]. Family members include protein kinase C-binding protein 1 (also known as ZMYND8) which acts as a transcriptional corepressor of the H3K4 demethylase JARID1D. ZMYND8 (zinc finger and MYND [myeloid, Nervy, and DEAF-1] domain containing 8) binds acetylated damaged chromatin, including actively transcribed regions, as a means of recruiting the nucleosome remodeling and histone deacetylation (NuRD) chromatin remodeling complex for transcriptional repression and DNA double-strand break (DSB) repair by homologous recombination (HR).
Pfam PF07350: Gig2-like (family)
This family includes Gig2 from Candida albicans, YbiU from Escherichia coli and uncharacterised proteins predominantly found in fungi and bacteria. Gig2 is a putative oxidoreductase thought to play a role in the undefined GlcNAc metabolic network. It folds into a single large domain with a cupin like double stranded beta-helix core surrounded by 20 alpha-helices. This protein shows similarity with 2- oxoglutarate dependant Fe containing oxygenases.
Pfam PF07687: Peptidase dimerisation domain (domain)
This domain consists of 4 beta strands and two alpha helices which make up the dimerisation surface of members of the M20 family of peptidases. This family includes a range of zinc metallopeptidases belonging to several families in the peptidase classification. Family M20 are Glutamate carboxypeptidases. Peptidase family M25 contains X-His dipeptidases.
Pfam PF09188: Domain of unknown function (DUF1951) (domain)
Members of this family of Mycoplasma hypothetical proteins adopt a helical structure, with a buried central helix. Their function has not, as yet, been determined.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.