SII-SWORD/CoKE huggingface dataset:
Pfam PF17631: Family of unknown function (DUF5512) (family)
This is a family of unknown function found in Bacillus.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF00383: Cytidine and deoxycytidylate deaminase zinc-binding region (domain)
Cytidine deaminase (3.5.4.5) (cytidine aminohydrolase) catalyses the hydrolysis of cytidine into uridine and ammonia while deoxycytidylate deaminase (3.5.4.12) (dCMP deaminase) hydrolyses dCMP into dUMP. Both enzymes are known to bind zinc and to require it for their catalytic activity . The deaminases possess either one or two conserved zinc-coordinating (Z) motifs, with the consensus amino acid signature H-x(1)-E-x(24,28)-P-C-x(2,4)-C. This motif is required for catalytic activity. Zinc coordination is mediated by a histidine and two cysteines . The CMP/dCMP-type deaminase domain consists of a central Î²-sheet with one or more Î±-helices on each side .

This entry represents the CMP/dCMP-type deaminase domain. Some enzymes, such as riboflavin biosynthesis protein PYRR, have a non-functional deaminase domain that lacks the catalytically essential zinc-binding residues .
Pfam PF11381: Protein of unknown function (DUF3185) (family)
Some members in this bacterial family of proteins are annotated as membrane proteins however this cannot be confirmed. Currently no function is known.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF21347: DUF3108-like (domain)
This is a domain found in bacteria which adopts a beta-barrel fold of the YmcC-like type.
Pfam PF18234: Violacein biosynthetic enzyme VioE (domain)
This domain is VioE present in Chromobacterium violaceum. VioE plays a key role in the biosynthesis of violacein. Violacein has potential medical applications as an antibacterial, anti-tryptanocidal, anti-ulcerogenic and as an anti-cancer drug. VioE forms a homodimer with a chiefly hydrophobic interface between the two VioE monomers.The fact that VioE adopts a fold normally associated with lipoprotein carrier proteins may be due to VioE for binding the hydrophobic polyethylene glycol.
Pfam PF17629: Family of unknown function (DUF5510) (family)
This is a family of unknown function found in Rickettsia. Family members are predicted to have 2 or 3 trans-membrane regions.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF18097: Vta1 C-terminal domain (domain)
This is the C-terminal domain of Vta1 proteins [pfam:PF04652] . Structural and functional analysis indicate that this C-terminal domain promotes the ATP-dependent double ring assembly of Vps4. Furthermore, it has been shown that it is necessary and sufficient for protein dimerization. Mutations in Lys-299 and Lys-302 completely abolished the ability of Vta1 to stimulate the ATPase activity of Vps4 while mutation in Lys-322 had no effect.
Pfam PF06125: Bacterial protein of unknown function (DUF961) (family)
This family consists of several hypothetical bacterial proteins of unknown function.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF21624: Virion DNA-directed RNA polymerase, plug insertion (domain)
This domain is found in Virion DNA-directed RNA polymerase from Bacteriophage N4 (vRNAP), responsible for the transcription of the early region of the double-stranded linear DNA genome of the lytic coliphage. This entry represents a short insertion that forms a globular module named plug, which blocks the activity of the protein.
Pfam PF00014: Kunitz/Bovine pancreatic trypsin inhibitor domain (domain)
Indicative of a protease inhibitor, usually a serine protease inhibitor. Structure is a disulfide rich  alpha+beta fold. BPTI (bovine pancreatic trypsin  inhibitor) is an extensively studied model structure. Certain family members are similar to the tick anticoagulant peptide (TAP, [swissprot:P17726]). This is a  highly selective inhibitor of factor Xa in the blood  coagulation pathways. TAP molecules are highly  dipolar, and are arranged to form a twisted two- stranded antiparallel beta-sheet followed by an alpha  helix.
Wikipedia: Kunitz domains are the active domains of proteins that inhibit the function of protein degrading enzymes or, more specifically, domains of Kunitz-type are protease inhibitors. They are relatively small with a length of about 50 to 60 amino acids and a molecular weight of 6 kDa. Examples of Kunitz-type protease inhibitors are aprotinin, Alzheimer's amyloid precursor protein (APP), and tissue factor pathway inhibitor (TFPI). Kunitz STI protease inhibitor, the trypsin inhibitor initially studied by Moses Kunitz, was extracted from soybeans.
Pfam PF08688: Apx/Shroom domain ASD1 (family)
This region is found in the actin binding protein Shroom which mediates apical contriction in epithelial cells and is required for neural tube closure.  ASD1 has been implicated directly in F-actin binding.
Wikipedia: In molecular biology, the Shroom protein family is a small group of related proteins that are defined by sequence similarity and in most cases by some link to the actin cytoskeleton. The Shroom (Shrm) protein family is found only in animals. Proteins of this family are predicted to be utilised in multiple morphogenic and developmental processes across animal phyla to regulate cells shape or intracellular architecture in an actin and myosin-dependent manner. While the founding member of the Shrm family is Shrm1, it appears that this protein is found only in Xenopus. In mice and humans, the Shrm family of proteins consists of:Shrm2, a protein involved in the morphogenesis, maintenance, and/or function of vascular endothelial cells.
Shrm3, a protein necessary for neural tube closure in vertebrate development as deficiency in Shrm results in spina bifida. Shrm3 is also conserved in some invertebrates, as orthologues can be found in sea urchins.
Shrm4, a regulator of cyto-skeletal architecture that may play an important role in vertebrate development. It is implicated in X-linked intellectual disability in humans.
Pfam PF06262: Zincin-like metallopeptidase (domain)
This family of proteins has a conserved HEXXH motif, suggesting they are putative peptidases of zincin fold. The structure of this family is a minimal version of the metalloprotease fold (PDB:3E11).
Pfam PF15742: Domain of unknown function (DUF4686) (coiled_coil)
This family of proteins is found in eukaryotes. Proteins in this family are typically between 498 and 775 amino acids in length. There is a conserved DLK sequence motif.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF22055: Bacterial xenogeneic silencer MvaT, C-terminal domain (domain)
This is the C-terminal DNA-binding domain of bacterial xenogeneic silencer MvaT. This domain adopts an alpha/beta structure consisting of a three-stranded antiparallel beta-sheet and two short helices packed on one side. It binds to AT-rich DNA at the minor groove.
Pfam PF05353: Delta Atracotoxin (family)
Delta atracotoxin produces potentially fatal neurotoxic symptoms in primates by slowing he inactivation of voltage-gated sodium channels.  The structure of atracotoxin comprises a core beta region containing a triple-stranded a thumb-like extension protruding from the beta region and a C-terminal helix.  The beta region contains a cystine knot motif, a feature seen in other neurotoxic polypeptides.
Pfam PF11036: Virulence promoting factor (family)
YqgB encodes adaptive factors that acts in synergy with vqfZ , enabling the bacteria to cope with the physical environment in vivo, facilitating colonisation of the host.
Pfam PF12089: Transmembrane domain of unknown function (DUF3566) (domain)
This family of proteins is functionally uncharacterised. This protein is found in bacteria. Proteins in this family are typically between 136 to 304 amino acids in length. This region represents a transmembrane region found at the C-terminus of the proteins.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF09279: Phosphoinositide-specific phospholipase C, efhand-like (domain)
Members of this family are predominantly found in phosphoinositide-specific phospholipase C. They adopt a structure consisting of a core of four alpha helices, in an EF like fold, and are required for functioning of the enzyme.
Pfam PF23038: Transcription elongation factor SPT5 homolog 1/2, KOW6 domain (domain)
This domain is found in Transcription elongation factor SPT5 homolog 1 (SPT51) from Arabidopsis thaliana and related plant proteins which are homologues of SPT5 from animals. SPT5 is a component of the elongation factor DRB-sensitivity inducing factor (DSIF) that plays multiple roles during transcription. SPT5 is a multidomain protein consisting of an N-terminal NusG domain, a tandem of KOW domains and and a mobile C-terminal-repeat region. This entry represents the KOW6 domain that is located between domains KOW5 and KOW7. It folds into a beta-barrel with an SH3-like topology.
Pfam PF14142: YrzO-like protein (family)
The YrzO-like protein family includes the B. subtilis YrzO protein [swissprot:C0H458] which is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 50 amino acids in length.
Pfam PF12932: Vesicle coat trafficking protein Sec16 mid-region (domain)
Sec16 is a multi-domain vesicle coat protein. This central region is the functional part of the molecules and thus is vital for the family's role in mediating the movement of protein-cargo between the organelles of the secretory pathway.
Pfam PF20040: Family of unknown function (DUF6442) (family)
This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 100 amino acids in length.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF20962: Lactococcus lactis phage p2, ORF12 (family)
ORF12 from Lactococcus lactis phage p2 is thought to be a chaperone for the tape measure protein that might help to maintain the tape measure protein in solution during tail assembly. This late- expressed protein shows an all-alpha structure with five alpha- helices oriented to form a hydrophobic cleft on the inner surface of the protein. It adopts a trimeric assembly, forming long spirals.
Pfam PF07738: Sad1 / UNC-like C-terminal (family)
The C. elegans UNC-84 protein is a nuclear envelope protein that is involved in nuclear anchoring and migration during development.  The S. pombe Sad1 protein localises at the spindle pole body. UNC-84 and and Sad1 share a common C-terminal region, that is often termed the SUN (Sad1 and UNC) domain. In mammals, the SUN domain is present in two proteins, Sun1 and Sun2.  The SUN domain of Sun2 has been demonstrated to be in the periplasm.
Wikipedia: SUN domains are conserved C-terminal protein regions a few hundred amino acids long. SUN domains are usually found following a transmembrane domain and a less conserved region of amino acids. Most proteins containing SUN domains are thought to be involved in the positioning of the nucleus in the cell. It is thought that SUN domains interact directly with KASH domains in the space between the outer and inner nuclear membranes to bridge the nuclear envelope and transfer force from the nucleoskeleton to the cytoplasmic cytoskeleton which enables mechanosensory roles in cells. SUN proteins are thought to localize to the inner nuclear membrane. The S. pombe Sad1 protein localises at the spindle pole body. In mammals, the SUN domain is present in two proteins, Sun1 and Sun2. The SUN domain of Sun2 has been demonstrated to be in the periplasm.
Pfam PF06344: Parechovirus Genome-linked protein (family)
This family is of the Parechovirus genome-linked protein Vpg type P3B.
Pfam PF19251: Minor capsid protein P2, DUF5899 (domain)
This is a domain of unknown function found in Minor capsid protein P2 from Paramecium bursaria Chlorella virus 1 and related sequences from Mimiviridae and Phycodnaviridae. Minor capsid protein P2 is one of the minor capsid proteins that constitute a network internal to the major capsid proteins and outside the lipid membrane. The minor capsid proteins glue and stabilize the capsomers. It also acts as a molecular tape measure protein that determines the size of the viral capsid.
Pfam PF09499: ApaLI-like restriction endonuclease (family)
This family includes R.ApaLI and R.XbaI restriction endonucleases. ApaLI recognises and cleaves the sequence GTGCAC.
Pfam PF11321: Protein of unknown function (DUF3123) (family)
This eukaryotic family of proteins has no known function.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF20297: MutS2 and Smr-associated SH3 domain (domain)
This is a SH3-like domain associated with the MutS-like ABC ATPase and Smr domains. It has been predicted to play a role in lesion recognition or alternatively in mediating contacts with RNA primers or misincorporated ribonucleotides during DNA repair or interacting with the ribosome at the intersection between DNA repair and ribosome rescue.
Pfam PF05117: Family of unknown function (DUF695) (family)
Family of uncharacterised bacterial proteins.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF20242: Emfourin (family)
This family represents a protealysin inhibitor called Emfourin, after M4 family inhibitor (M4in), as protealysin is a metallo- endopeptidase from MEROPS peptidase family M4. Emfourin is a potent inhibitor that forms a 1:1 stoichiometry complex with protealysin.
Pfam PF16900: Replication protein A OB domain (domain)
Replication protein A contains two OB domains in it's DNA binding region. This is the second of the OB domains.
Pfam PF06770: Actin-rearrangement-inducing factor (Arif-1) (family)
This family consists of several Nucleopolyhedrovirus actin-rearrangement-inducing factor (Arif-1) proteins. In response to Autographa californica multicapsid nuclear polyhedrosis virus (AcMNPV) infection, a sequential rearrangement of the actin cytoskeleton occurs this is induced by Arif-1. Arif-1 is tyrosine phosphorylated and is located at the plasma membrane as a component of the actin rearrangement-inducing complex.
Pfam PF20890: Dbr1, C-terminal domain (domain)
Dbr1 is an eukaryotic intron debranching enzyme that hydrolyses the linkages produced by the spliceosome in RNA for them to be processed into essential cellular factors, such as snoRNA and miRNA. This protein is organized into an N-terminal metallophosphoesterase (MPE) domain ([pfam:PF00149]) and a C-terminal domain (CTD, this entry). This domain consists of four alpha-helices and three connecting loops. It is located on the posterior of the protein, opposite the active site and is joined to the MPE domain by an extended linker region.
Pfam PF02348: Cytidylyltransferase (family)
This family consists of two main Cytidylyltransferase activities: 1) 3-deoxy-manno-octulosonate cytidylyltransferase,, [ec:2.7.7.38] catalysing the reaction:- CTP + 3-deoxy-D-manno-octulosonate  diphosphate + CMP-3-deoxy-D-manno-octulosonate, 2) acylneuraminate cytidylyltransferase [ec:2.7.7.43],, catalysing  the reaction:- CTP + N-acylneuraminate  diphosphate + CMP-N-acylneuraminate. NeuAc cytydilyltransferase of Mannheimia haemolytica has been characterised describing kinetics and regulation by substrate charge, energetic charge and amino-sugar demand.
Pfam PF15888: Folded gastrulation N-terminus (domain)
This is the N-terminal domain of the folded gastrulation protein. Folded gastrulation is required for morphogenic movements during gastrulation and nervous system development. It may act as a secreted signal and activate the G protein alpha subunit. This domain may be the G protein-coupled receptor ligand.
Pfam PF15441: RhoGEF 5/35 N-terminal disordered region (disordered)
This entry includes Rho guanine nucleotide exchange factor 5 and Rho guanine nucleotide exchange factor 35. However, this region is disordered and the RhoGEF function resides in a different domain [pfam:PF00621].
Pfam PF23325: GBF1-like, tetratrico peptide repeats (repeat)
These predicted tetratrico peptide repeats (TPR) are found at the C-terminal end of human name Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 (GBF1) and similar eukaryotic proteins. GBF1 is involved in trafficking in the early secretory pathway and required for the assembly of the Golgi apparatus. This entry is often found associated with [pfam:PF12783] and [pfam:PF01369].
Pfam PF24321: Domain of unknown function (DUF7493) (domain)
This is a domain of unknown function found in uncharacterised sequences from fungi. Some of these sequences are annotated as sphingosine kinases. This domain may adopt a PH-like fold.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF01874: ATP:dephospho-CoA triphosphoribosyl transferase (family)
The citG gene is found in a gene cluster with citrate lyase subunits.  The function of the CitG protein was elucidated as ATP:dephospho-CoA triphosphoribosyl transferase.
Pfam PF21082: Mechanosensitive ion channel MscS, C-terminal (domain)
This entry includes small conductance mechanosensitive channels (MscS), which assembles to a homoheptameric complex. Each monomer consists of a N-terminal transmembrane region and a large cytoplasmic segment composed of a five-stranded antiparallel beta-sheet domain (beta-domain, [pfam:PF00924]) and a C-terminal alpha/beta-domain. This is the C-terminal domain of McsS which, together with the middle beta-domain, creates a framework that connects to the cytoplasm through distinct openings.
Wikipedia: Small conductance mechanosensitive ion channels (MscS) provide protection against hypo-osmotic shock in bacteria, responding both to stretching of the cell membrane and to membrane depolarization. In eukaryotes, they fulfill a multitude of important functions in addition to osmoregulation. They are present in the membranes of organisms from the three domains of life: bacteria, archaea, fungi and plants.
Pfam PF13135: Protein of unknown function (DUF3947) (domain)
This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 80 amino acids in length.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF02296: Alpha adaptin AP2, C-terminal domain (domain)
Alpha adaptin is a hetero tetramer which regulates clathrin-bud formation. The carboxyl-terminal appendage of the alpha subunit regulates translocation of endocytic accessory proteins to the bud  site.
Wikipedia: The C-terminal domain of Beta2-adaptin is a protein domain is involved in cell trafficking by aiding import and export of substances in and out of the cell.
Pfam PF04522: Broad bean mottle virus, Gp1, N-terminal (family)
This region represents the N terminus of Broad bean mottle virus, Gp1 (2a protein), and is always found N terminal to a predicted RNA-dependent RNA polymerase region ([pfam:PF00978]).
Pfam PF18389: TrmO C-terminal domain (domain)
This domain is found at the C-terminus of TrmO tRNA methyltransferase proteins.  This domain has a RelE fold.
Pfam PF10408: Ubiquitin elongating factor core (family)
This is the most conserved part of the core region of Ufd2P ubiquitin elongating factor or E4, running from helix alpha-11 to alpha-38. It consists of 31 helices of variable length connected by loops of variable size forming a compact unit; the helical packing pattern of the compact unit consists of five structural repeats that resemble tandem Armadillo (ARM) repeats. This domain is involved in ubiquitination as it binds Cdc48p and escorts ubiquitinated proteins from Cdc48p to the proteasome for degradation. The core is structurally similar to the nuclear transporter protein importin-alpha. The core is associated with the U-box at the C-terminus, [pfam:PF04564], which has ligase activity.