SII-SWORD/CoKE huggingface dataset:
Pfam PF24699: Domain of unknown function (DUF7663) (domain)
This domain is found in uncharacterised bacterial proteins. It is frequently found in combination with [pfam:PF21818]. It is predicted to adopt a complex alpha/beta structure composed of a curved beta-sheet that encloses an alpha-helix and a number of helices packed on its exterior.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF05407: Rubella virus endopeptidase (family)
Corresponds to Merops family C27. Required for processing of the rubella virus replication protein.
Pfam PF25139: Secreted LysM effector LysM14, C-terminal domain (domain)
This domain is found at the C-terminal end of Secreted LysM effector LysM14 from Penicillium expansum, which might have a role in sequestration of chitin oligosaccharides to dampen host defense. This domain is predicted to have a mainly beta configuration.
Pfam PF15468: Domain of unknown function (DUF4636) (family)
This family of proteins is found in eukaryotes. Proteins in this family are typically between 196 and 244 amino acids in length.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF20585: Putative pectate lyase-like adhesive domain (repeat)
This putative domain is found at the N-terminus of a large number of bacterial proteins. Its adhesive function was described in Lactobacillus reuteri serine-rich repeat proteins. Structure predictions show it is composed of a beta solenoid repeat related to Pectate lyase.
Pfam PF17352: Male Flower Specific protein 18 (family)
This domain family is found on MFS18 protein from Maize. MFS18 mRNA accumulates in the glumes and in anther walls, paleas and lemmas of mature florets. It is particularly associated with the vascular bundle in the glumes and encodes a polypeptide of 12 kDa, rich in glycine, proline and serine that has similarities with other plant structural proteins. There is no known function of this family in Maize or other Poaceae.
Pfam PF18622: RctB helix turn helix domain (domain)
RctB is a highly conserved 75.3 kD protein (658 residues), which is unique to the Vibrionaceae. The first 500 amino acids of RctB are sufficient to mediate oriCII-based replication and its C-terminal 165 residues may mediate regulatory processes. RctB contains at least three DNA binding winged-helix-turn-helix motifs, and mutations within any of these severely compromise biological activity. This entry describes domain 1 located at the N-terminal region of RctB proteins. Mutational analysis show that it binds oriCII DNA, and that this function is critical for the capacity of RctB to mediate oriCII-based replication.
Pfam PF21125: BRCA1-A complex subunit Abraxas 1 MPN domain (domain)
This entry represents the MPN domain from the Abraxas protein. Abraxas is a component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked polyubiquitin, leaving the last ubiquitin chain attached to its substrates.
Pfam PF13241: Putative NAD(P)-binding (domain)
This domain is found in fungi, plants, archaea and bacteria.
Pfam PF06463: Molybdenum Cofactor Synthesis C (domain)
This region contains two iron-sulphur (3Fe-4S) binding sites. Mutations in this region of  [swissprot:O14940] cause MOCOD (Molybdenum Co-Factor Deficiency) type A.
Pfam PF05425: Copper resistance protein D (family)
Copper sequestering activity displayed by some bacteria is determined by copper-binding protein products of the copper resistance operon (cop). CopD, together with CopC, perform copper uptake into the cytoplasm.
Pfam PF12416: Cep120 protein (family)
This family includes the Cep120 protein which is associated with centriole structure and function.
Pfam PF16920: Leucine rich repeat C-terminal motif (conserved_site)
This entry represents the Leucine Rich Repeat C-terminal (LRRCT) capping motif from TRK receptors.
Pfam PF05857: TraX protein (family)
This family consists of several bacterial TraX proteins. TraX is responsible for the amino-terminal acetylation of F-pilin subunits.
Pfam PF19113: Family of unknown function (DUF5799) (family)
This is a family of proteins of unknown function predominantly found in Halobacteria.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF17791: Macroglobulin domain MG3 (domain)
This entry corresponds to the MG3 domain found in complement components C3, C4 and C5.
Pfam PF20783: DUF5575 N-terminal domain (domain)
This entry represents the N-terminal domain from a family of Chordate proteins that includes C19orf68. These proteins appear to be transposon related. This domain appears to be related to the WRKY-like DNA-binding domains.
Pfam PF21513: SidD, C-terminal (domain)
SidD from Legionella pneumophila is a virulence effector that plays a role in hijacking the host vesicular trafficking by recruiting the small guanosine triphosphatase (GTPase) Rab1 to the cytosolic face of the Legionella-containing vacuole (LCVs). This entry represents the C-terminal helical domain, which targets SidD to the Golgi and critical for membrane localization within host cells. A two-helix bundle at the very C-terminal determines SidD specificity.
Pfam PF21858: Family of unknown function (DUF6914) (family)
This is a family of uncharacterized proteins. They are predicted to adopt a globular structure that resembles the conserved core of the PPPDE superfamily (after Permuted Papain fold Peptidases of DsRNA viruses and Eukaryotes) consisting of thiol peptidases with a circularly permuted papain-like fold.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF08939: Basophilic leukemia-expressed protein Bles03 (domain)
This domain is found in Basophilic leukemia-expressed protein Bles03 from humans (also known as UPF0696 protein C11orf68, [swissprot:Q9H3H3]) and various proteins from eukaryotes, bacteria and archaea. Bles03 has been suggested to have phosphothreonine lyase activity and to play a role in the biosynthesis of dehydro amino acids. It shows a two-layer sandwich architecture with a a nine-stranded beta-sheet and three alpha-helices on each side.
Pfam PF24303: Domain of unknown function (DUF7485) (repeat)
This entry includes uncharacterised sequences mainly from actinobacteria. According to structure predictions, they may form a beta-propeller-like fold consisting of four repeated units containing three (in one of them) and four (on the other three units) beta-strands. There is an additional unit which is slightly different that resembles a seven stranded beta-sandwich.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF09452: ESCRT-I subunit Mvb12 (domain)
The endosomal sorting complex required for transport (ESCRT) complexes play a critical role in receptor down-regulation and retroviral budding. A new component of the ESCRT-I complex was identified, multivesicular body sorting factor of 12 kD (Mvb12), which binds to the coiled-coil domain of the ESCRT-I subunit vacuolar protein sorting 23 (Vps23).
Pfam PF11107: Fanconi anemia group F protein (FANCF) (repeat)
FANCF regulates its own expression by methylation at both mRNA and protein levels. Methylation-induced inactivation of FANCF has an important role on the occurrence of ovarian cancers by disrupting the FA-BRCA pathway.
Pfam PF07409: Phage protein GP46 (family)
This family contains GP46 phage proteins (approximately 120 residues long).
Pfam PF14596: STAT6 C-terminal (family)
This family represents the C-terminus of mammalian STAT6 (Signal transducer and activator of transcription 6), it contains an LXXLL motif which binds to NCOA1 (Nuclear receptor coactivator 1).
Pfam PF06961: Protein of unknown function (DUF1294) (family)
This family includes a number of hypothetical bacterial and archaeal proteins of unknown function.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF06809: Neural proliferation differentiation control-1 protein (NPDC1) (family)
This family consists of several neural proliferation differentiation control-1 (NPDC1) proteins. NPDC1 plays a role in the control of neural cell proliferation and differentiation. It has been suggested that NPDC1 may be involved in the development of several secretion glands. This family also contains the C-terminal region of the C. elegans protein CAB-1 ([swissprot:Q93249]) which is known to interact with AEX-3.
Pfam PF24170: Straight fiber protein PB4 second Fn3-like domain (domain)
This entry represents the second Fn3-like domain of the Straight fiber protein PB4 found in T5-like phages. PB4 along with PB3, forms the central straight fiber, bearing the receptor binding protein PB5 at its C terminus. Upon PB5 binding to the host receptor FhuA, the central fiber reorganises and undergoes structural rearrangements that lead to its bending, bringing PB3 close to the host membrane for anchoring. The PB4-PB3 interactions are ensured by the distal loops of the second of the three Fn3-like domains of PB4. These interactions are disrupted upon binding to the host receptor and the string of the three PB4 Fn3-like domains undergoes drastic conformational changes.
Pfam PF04592: Selenoprotein P, N terminal region (family)
SelP is the only known eukaryotic selenoprotein that contains multiple selenocysteine (Sec) residues, and accounts for more than 50% of the selenium content of rat and human plasma. It is thought to be glycosylated.  SelP may have antioxidant properties.  It can attach to epithelial cells, and may protect vascular endothelial cells against peroxynitrite toxicity. The high selenium content of SelP suggests that it may be involved in selenium intercellular transport or storage. The promoter structure of bovine SelP suggest that it may be involved in countering heavy metal intoxication, and may also have a developmental function. The N-terminal region of SelP can exist independently of the C terminal region.  Zebrafish selenoprotein Pb ([swissprot:Q98SV0]) lacks the C terminal Sec-rich region, and a protein encoded by the rat SelP gene and lacking this region has also been reported. N-terminal region contains a conserved SecxxCys motif, which is similar to the CysxxCys found in thioredoxins.  It is speculated that the N terminal region may adopt a thioredoxin fold and catalyse redox reactions. The N-terminal region also contains a His-rich region, which is thought to mediate heparin binding.  Binding to heparan proteoglycans could account for the membrane binding properties of SelP.  The function of the bacterial members of this family is uncharacterised.
Wikipedia: In molecular biology, the protein domain selenoprotein P (SelP) is the only known eukaryotic selenoprotein that contains multiple selenocysteine (Sec) residues. It is a secreted glycoprotein, often found in the plasma. Its precise function remains to be elucidated; however, it is thought to have antioxidant properties. This particular protein contains two domains: the C terminal and N terminal domain. The N-terminal domain is larger than the C terminal and the N-terminal is thought to be glycosylated.
Pfam PF02199: Saposin A-type domain (family)
The saposin A-type domain is a ~40 amino acid domain present in the saposin precursor, prosaposin, in the propeptides that are cleaved off in the activation reaction. The domain is named after the small lysosomal proteins, saposins, which serve as sphingolipid hydrolase activator proteins in vertebrates. The mammalian saposins are synthesized as a single precursor molecule (prosaposin) which contains four saposin B-type domains yielding the active saposins A, B, C and D after proteolytic cleavage, and two saposin A-type domains in the extremities that are removed in the activation reaction. The saposin A-type domain may play a role in targeting, as propeptides containing the saposin A-type domain of the C terminus of prosaposin and of the N-terminal part of pulmonary surfactant-associated protein B are involved in the transport to the lysosome and to secretory granules (lamellar bodies, which are lysosomal-like organelles), respectively .

Some proteins known to contain a saposin A-type domain:


 * Mammalian proactivator polypeptide, the saposin precursor (prosaposin) that is processed into saposins A, B, C and D.
 * Mammalian pulmonary surfactant-associated protein B (SP-B), a surface tension reducing surfactant secreted by type II epithelial cells.
Wikipedia: The saposin domains refers to two evolutionally-conserved protein domains found in saposin and related proteins (SAPLIP). Saposins are small lysosomal proteins that serve as activators of various lysosomal lipid-degrading enzymes. They probably act by isolating the lipid substrate from the membrane surroundings, thus making it more accessible to the soluble degradative enzymes. All mammalian saposins are synthesized as a single precursor molecule (prosaposin) which contains four Saposin-B domains, yielding the active saposins after proteolytic cleavage, and two Saposin-A domains that are removed in the activation reaction.
Pfam PF09679: Type-F conjugative transfer system pilin chaperone (TraQ) (family)
This entry represents TraQ, a protein that makes a specific interaction with pilin (TraA) to aid its transfer through the inner membrane during the process of F-type conjugative pilus assembly.
Pfam PF00961: LAGLIDADG endonuclease (domain)
Homing endonucleases (HEnases) form a large and highly diverse class of proteins encoded by introns and inteins that confer mobility to their host genetic elements. LAGLIDADG HEnases are structured into two tandemly repeated homing endonuclease-like domains . This entry represents the homing endonuclease LAGLIDADG domain .
Wikipedia: The homing endonucleases are a collection of endonucleases encoded either as freestanding genes within introns, as fusions with host proteins, or as self-splicing inteins. They catalyze the hydrolysis of genomic DNA within the cells that synthesize them, but do so at very few, or even singular, locations. Repair of the hydrolyzed DNA by the host cell frequently results in the gene encoding the homing endonuclease having been copied into the cleavage site, hence the term 'homing' to describe the movement of these genes. Homing endonucleases can thereby transmit their genes horizontally within a host population, increasing their allele frequency at greater than Mendelian rates.
Pfam PF14056: Domain of unknown function (DUF4250) (family)
This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 60 amino acids in length. There are two completely conserved residues (N and R) that may be functionally important.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF11730: Protein of unknown function (DUF3297) (family)
This family is expressed in Proteobacteria and Actinobacteria. The function is not known.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF06995: Phage P2 GpU (family)
This family consists of several bacterial and phage proteins of around 130 residues in length which seem to be related to the bacteriophage P2 GpU protein ([swissprot:O64315]) which is thought to be involved in tail assembly.
Pfam PF03850: Transcription factor Tfb4 (domain)
This family appears to be distantly related to the VWA domain.
Pfam PF10246: Mitochondrial ribosomal protein MRP-S35 (family)
This is a family of short mitochondrial ribosomal proteins, less than 200 amino acids long. that are highly conserved from worms to humans. The structure has previously been referred to as MRP-S18 but the current numbering fits the preferred nomenclature from these authors.
Pfam PF00035: Double-stranded RNA binding motif (domain)
Sequences gathered for seed by HMM_iterative_training Putative motif shared by proteins that bind to dsRNA. At least some DSRM proteins seem to bind to specific RNA targets. Exemplified by Staufen, which is involved in localisation of at least five different mRNAs in the early Drosophila embryo. Also by interferon-induced protein kinase in humans, which is part of the cellular response to dsRNA.
Pfam PF15060: Differentiation and proliferation regulator (family)
Pancreatic progenitor cell differentiation and proliferation factor-like protein (PPDFL) is alternatively named Exocrine differentiation and proliferation factor-like protein. PPDFL regulates exocrine cell fate. This protein is highly expressed in exocrine progenitor cells which eventually differentiate to form exocrine pancreatic cells.
Pfam PF18983: Family of unknown function (DUF5717)C-terminal (domain)
This is a C-terminal domain of a family of unknown function found in bacteria.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF08320: PIG-X / PBN1 (domain)
Mammalian PIG-X and yeast PBN1 are essential components of glycosylphosphatidylinositol-mannosyltransferase I.  These enzymes are involved in the transfer of sugar molecules.
Pfam PF21758: Bacterial proteasome assembling chaperone-like protein (domain)
This protein family includes LpdD [swissprot:F9UT68] a protein found in the gallate decarboxylase operon. Structurally this protein is closely related to eukaryotic proteasome assembling chaperone. This suggests that the proteins in this family may play a similar role. Protein in this family have three highly conserved histidine residue that may be important for function.
Pfam PF11241: Protein of unknown function (DUF3043) (family)
Some members in this family of proteins with unknown function are annotated as membrane proteins. This cannot be confirmed.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF01563: Alphavirus E3 glycoprotein (family)
This protein is found in some alphaviruses as a virion associated spike protein.
Wikipedia: Alphavirus is a genus of RNA viruses, the sole genus in the Togaviridae family. Alphaviruses belong to group IV of the Baltimore classification of viruses, with a positive-sense, single-stranded RNA genome. There are 32 alphavirus species, which infect various vertebrates such as humans, rodents, fish, birds, and larger mammals such as horses, as well as invertebrates. Alphaviruses that can infect both vertebrates and arthropods are referred dual-host alphaviruses, while insect-specific alphaviruses such as Eilat virus and Yada yada virus are restricted to their competent arthropod vector. Transmission between species and their vertebrate hosts occurs mainly via mosquitoes, making the alphaviruses a member of the collection of arboviruses – or arthropod-borne viruses. Alphavirus particles are enveloped, have a 70 nm diameter, tend to be spherical, and have a 40 nm isometric nucleocapsid.
Pfam PF17593: Family of unknown function (DUF5490) (family)
This is a family of unknown function found in Myoviridae.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF10356: Required for respiratory growth protein 7 (family)
This family includes fungal proteins, such as Required for respiratory growth protein 7 (RRG7) whose function is unknown.
Pfam PF16543: DRG Family Regulatory Proteins, Tma46 (domain)
DFRP_C is a family of eukaryotic translation machinery-associated protein 46 proteins that are the binding partner for the highly conserved Developmentally Regulated GTP-binding (DRG) GTPases. Thus this family is referred to as DRG Family Regulatory Proteins (DFRP). Binding of this DFRP modulates the function of the GTPase.
Pfam PF16267: Domain of unknown function (DUF4920) (family)
This family consists of uncharacterized proteins around 190 residues in length and is mainly found in various Bacteroides species. The function of this family is unknown.