SII-SWORD/CoKE huggingface dataset:
Pfam PF08429: PLU-1-like protein (family)
Sequences in this family bear similarity to the central region of PLU-1 ([swissprot:Q9Y3Q5]). This is a nuclear protein that may have a role in DNA-binding and transcription, and is closely associated with the malignant phenotype of breast cancer. This region is found in various other Jumonji/ARID domain-containing proteins (see [pfam:PF02373], [pfam:PF01388]).
Pfam PF21088: Mechanosensitive ion channel, transmembrane helices 2/3 (domain)
This entry includes small conductance mechanosensitive channels (MscS), which assembles to a homoheptameric complex. Each monomer consists of a N-terminal transmembrane region and a large cytoplasmic segment composed of a five-stranded antiparallel beta-sheet (middle/second) domain and a C-terminal alpha/beta-domain. The N-terminal region consists of three membrane spanning helices (TM1, TM2 and TM3), TM2 and TM3 are represented in this entry. In the heptamer, the permeation pathway is formed by the packing of TM3s, flanked by TM1-TM2 helical hairpins.
Wikipedia: Small conductance mechanosensitive ion channels (MscS) provide protection against hypo-osmotic shock in bacteria, responding both to stretching of the cell membrane and to membrane depolarization. In eukaryotes, they fulfill a multitude of important functions in addition to osmoregulation. They are present in the membranes of organisms from the three domains of life: bacteria, archaea, fungi and plants.
Pfam PF06761: Intracellular multiplication and human macrophage-killing (family)
This family represents a conserved region within several bacterial proteins that resemble IcmF, which has been proposed to be involved in Vibrio cholerae cell surface reorganisation, resulting in increased adherence to epithelial cells and increased conjugation frequency. Note that many family members are hypothetical proteins.
Pfam PF02477: Nucleocapsid N protein (family)
The nucleoprotein of the ssRNA negative-strand Nairovirus is an internal part of the virus particle.
Pfam PF11191: Protein of unknown function (DUF2782) (family)
This is a bacterial family of proteins whose function is unknown.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF12620: Protein of unknown function (DUF3778) (family)
This domain family is found in eukaryotes, and is typically between 48 and 61 amino acids in length. There is a conserved LRF sequence motif.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF09015: NgoMIV restriction enzyme (domain)
Members of this family are prokaryotic DNA restriction enzymes, exhibiting an alpha/beta structure, with a central region comprising a mixed six-stranded beta-sheet with alpha-helices on each side. A long 'arm' protrudes out of the core of the domain between strands beta2 and beta3 and is mainly involved in the tetramerisation interface of the protein. These restriction enzymes recognise the double-stranded sequence GCCGGC and cleave after G-1.
Pfam PF22957: NUP210 Ig-like domain (domain)
This domain is found in the homologues of Nuclear pore membrane glycoprotein 210 (NUP210). NUP210 is essential for nuclear pore assembly and fusion, nuclear pore spacing, as well as for its structural integrity. NUP210 is composed of multiple immunoglobin-like (Ig-like) domains and forms a ring around the NPC within the NE lumen. The domain represented by this entry is one of these constituent Ig-like domain and has a significant structural similarity to cadherin domains.
Pfam PF07845: Protein of unknown function (DUF1636) (family)
The sequences featured in this family are derived from a number of hypothetical prokaryotic proteins. The region in question is approximately 130 amino acids long.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF14370: C-terminal topoisomerase domain (family)
This domain is found at the C-terminal of topoisomerase and other similar enzymes.
Pfam PF12682: Flavodoxin (domain)
This is a family of flavodoxins.  Flavodoxins are electron transfer proteins that carry a molecule of non-covalently bound FMN.
Pfam PF16802: Domain of unknown function (DUF5070) (family)
This protein family found in Chlamydia includes CT296 from Chlamydia trachomatis, which show structural features typical of non-heme Fe(II) 2-oxoglutarate-dependent enzymes. The specific function of these proteins is not known.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF14814: Bifunctional transglycosylase second domain (domain)
UB2H is the second domain of the transglycosylases, or penicillin-binding proteins PBP1bs)), the multi-domain membrane proteins essential for cell wall synthesis that are targeted by penicillin antibiotics. The exact function of the UB2H domain is uncertain, but it may act as the binding component of PBP1b with different binding partners, or it may participate in the regulation between DNA repair and/or synthesis and cell wall formation during the bacterial cell cycle.
Pfam PF09523: Protein of unknown function (DUF2390) (family)
Members of this family are bacterial hypothetical proteins, about 160 amino acids in length, found in various proteobacteria, including members of the genera Pseudomonas and Vibrio. The C-terminal region is poorly conserved and is not included in the model.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF14221: Domain of unknown function (DUF4330) (family)
This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria, archaea and eukaryotes. Proteins in this family are typically between 165 and 177 amino acids in length. There is a single completely conserved residue G that may be functionally important.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF18789: Defence against restriction A C-terminal (domain)
This is a mostly alpha-helical domain found in polyvalent proteins of phages and prophages. In Phage P1, the DarA protein is a component of the phage P1 head.
Pfam PF01914: MarC family integral membrane protein (family)
Integral membrane protein family that includes the protein MarC. MarC was thought to be a multiple antibiotic resistance protein. Nevertheless, a study has shown that MarC is not involved in  multiple antibiotic resistance. The function of this family is unclear.
Pfam PF10839: Protein of unknown function (DUF2647) (family)
This eukaryotic family of proteins are annotated as ycf68 but have no known function.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF07395: Mig-14 (family)
This family contains a number of bacterial mig-14 proteins (approximately 270 residues long). In Salmonella, mig-14 contributes to resistance to antimicrobial peptides, although the mechanism is not fully understood.
Pfam PF16753: TNF-alpha-Inducing protein of Helicobacter (family)
Tipalpha is secreted from H. pylori as dimers and enters the gastric cells. It binds to DNA via the positively charged surface-patch formed between the two monomers of the crystal structure by the loop between helices alpha1 and alpha2. Each monomer consists of a helical domain and a mixed domain.
Pfam PF10689: Protein of unknown function (DUF2496) (family)
This family consists of proteins from Gammaproteobacteria spp. Many members are annotated as being like the E coli protein YbaM.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF22449: Fim1F, C-terminal domain (domain)
This domain is found at the C-terminal end of the putative fimbrium tip subunit Fim1F from Parabacteroides distasonis, which contain an N-terminal domain ([pfam:PF06321]) and a slightly larger C-terminal domain (this entry) with a transthyretin-like fold that contains seven core beta-strands arranged in two beta-sheets an extra conserved 'appendage' of two amphipathic beta-strands.
Pfam PF08386: TAP-like protein (family)
This is a family of putative bacterial peptidases and hydrolases that bear similarity to a tripeptidyl aminopeptidase isolated from Streptomyces lividans ([swissprot:Q54410]). A member of this family ([swissprot:Q6E3K7]) is thought to be involved in the C-terminal processing of propionicin F, a bacteriocidin characterised from Propionibacterium freudenreichii.
Wikipedia: The alpha/beta hydrolase superfamily is a superfamily of hydrolytic enzymes of widely differing phylogenetic origin and catalytic function that share a common fold. The core of each enzyme is an alpha/beta-sheet, containing 8 beta strands connected by 6 alpha helices. The enzymes are believed to have diverged from a common ancestor, retaining little obvious sequence similarity, but preserving the arrangement of the catalytic residues. All have a catalytic triad, the elements of which are borne on loops, which are the best-conserved structural features of the fold.
Pfam PF25004: Domain of unknown function (DUF7782) (domain)
This is a presumed domain found at the C-terminal of a group of uncharacterised sequences from Nocardia sp. According to structure predictions, this domain may adopt a winged helix fold with an insertion consisting of a long beta-hairpin and a short beta-strand.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF19173: Family of unknown function (DUF5855) (family)
This is a family of uncharacterised proteins of unknown function predominantly found in Phycodnaviridae.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF12449: Protein of unknown function (DUF3684) (family)
This domain family is found in eukaryotes, and is typically between 1072 and 1090 amino acids in length.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF15547: Steroid receptor-associated and regulated protein (family)
Steroid receptor-associated and regulated protein is also known as  ER-related factor, ERRF, or C1orf64. It is thought to regulate the  transcriptional function of androgen and oestrogen receptors.  Proteins in this family are typically between 145 and 169 amino  acids in length, and have a conserved IDC sequence motif.
Pfam PF12868: Domain of unknwon function (DUF3824) (domain)
This is a repeating domain found in fungal proteins. It is proline-rich, and the function is not known.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF12758: Protein of unknown function (DUF3813) (family)
This is an uncharacterised family of Bacillus proteins.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF06061: Baculoviridae ME53 (family)
ME53 is one of the major early-transcribed genes. The ME53 protein is reported to contain a putative zinc finger motif.
Pfam PF09194: Restriction endonuclease BsobI (domain)
Members of this family of prokaryotic restriction endonucleases recognise the double-stranded sequence CYCGRG (where Y = T/C, and R = A/G) and cleave after C-1. They catalyse the endonucleolytic cleavage of DNA to give specific double-stranded fragments with terminal 5'-phosphates.
Wikipedia: In molecular biology, the restriction endonuclease BsobI/AvaI family of enzymes includes the AvaI and BsoBI restriction endonucleases from Anabaena variabilis and Bacillus stearothermophilus, both of which recognise the double-stranded sequence CYCGRG and cleave after C-1.
Pfam PF06203: CCT motif (conserved_site)
This short motif is found in a number of plant proteins. It is rich in basic amino acids and has been called a CCT motif after Co, Col and Toc1. The CCT motif is about 45 amino acids long and contains a putative nuclear localisation signal within the second half of the CCT motif. Toc1 mutants have been identified in this region.
Pfam PF20499: Domain of unknown function (DUF6729) (domain)
This presumed domain is functionally uncharacterised. This domain family is found in eukaryotes, and is approximately 220 amino acids in length.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF17729: Family of unknown function (DUF5569) (family)
This is a family of unknown function found in mammals.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF10917: Fungus-induced protein (family)
This entry represents fungus-induced proteins which may have role in hypoxia response.
Pfam PF25082: GIPC1-3 GH2 domain (domain)
This entry includes GIPC proteins (GAIP C-terminus-interacting protein) GIPC1-3, PDZ domain-containing proteins that may act as scaffold proteins linking heterotrimeric G-proteins to seven-transmembrane-type WNT receptor or to receptor tyrosine kinases. They might play key roles in carcinogenesis and embryogenesis through modulation of growth factor signaling and cell adhesion. GIPCs are proteins with a GIPC homology 1 (GH1) domain, a central PDZ domain and a GH2 domain, the latter is represented in this entry. This domain mediates the interaction with myosin VI and is involved in homodimerisation in the autoinhibited state.
Pfam PF07896: Protein of unknown function (DUF1674) (family)
The members of this family are sequences derived from hypothetical eukaryotic and bacterial proteins. The  region in question is approximately 60 residues long.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF19629: Family of unknown function (DUF6133) (family)
This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 73 and 87 amino acids in length. There are two conserved sequence motifs: KIL and LLLAGLY.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF21070: Type VI secretion protein IcmF helical domain (domain)
This entry represents the alpha-helical domain from the Type VI secretion protein IcmF. This domain is also found in the TssM protein where it forms part of the tip complex.
Pfam PF04992: RNA polymerase Rpb1, domain 6 (domain)
RNA polymerases catalyse the DNA dependent polymerisation of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases).  This domain, domain 6, represents a mobile module of the RNA polymerase. Domain 6 forms part of the shelf module.  This family appears to be specific to the largest subunit of RNA polymerase II.
Pfam PF01035: 6-O-methylguanine DNA methyltransferase, DNA binding domain (domain)
This is the C-terminal DNA-binding domain of 6-O-methylguanine-DNA methyltransferases.
Pfam PF22679: Type I restriction enzyme subunit R domain 3 (domain)
This domain is found in a restriction (R) subunit of a number of type I restriction enzymes. Subunit R is required for both nuclease and ATPase activities, but not for modification. This domain folds into an alpha/beta structure consisting of a central beta-sheet and alpha-helices packed on both sides of it.
Pfam PF02796: Helix-turn-helix domain of resolvase (domain)
Site-specific recombination plays an important role in DNA rearrangement in prokaryotic organisms. Two types of site-specific recombination are known to occur:

 * Recombination between inverted repeats resulting in the reversal of a DNA segment.
 * Recombination between repeat sequences on two DNA molecules resulting in their cointegration, or between repeats on one DNA molecule resulting in the excision of a DNA fragment.

Site-specific recombination is characterised by a strand exchange mechanism that requires no DNA synthesis or high energy cofactor; the phosphodiester bond energy is conserved in a phospho-protein linkage during strand cleavage and re-ligation.

Two unrelated families of recombinases are currently known . The first, called the 'phage integrase' family, groups a number of bacterial phage and yeast plasmid enzymes. The second , called the 'resolvase' family, groups enzymes which share the following structural characteristics: an N-terminal catalytic and dimerization domain that contains a conserved serine residue involved in the transient covalent attachment to DNA IPR006119, and a C-terminal helix-turn-helix DNA-binding domain.
Wikipedia: Helix-turn-helix is a DNA-binding domain (DBD). The helix-turn-helix (HTH) is a major structural motif capable of binding DNA. Each monomer incorporates two α helices, joined by a short strand of amino acids, that bind to the major groove of DNA. The HTH motif occurs in many proteins that regulate gene expression. It should not be confused with the helix–loop–helix motif.
Pfam PF24940: Dep-1 fifth Fn3-like domain (domain)
This domain is found in the Receptor-type tyrosine-protein phosphatase Dep-1 from Caenorhabditis elegans and related proteins. Dep-1 is involved in the dephosphorylation of the receptor let-23 and the beta-integrin subunit pat-3. It is involved in the regulation of the  cell fate during the development of the vulva and the excretory system. It is also involved indirectly in the negative regulation of let-23 signaling and vulval induction. Dep-1 is a multidomain protein which is predicted to contain a number of Fn3-like domains arranged in tandem. This entry represents the fifth of them.
Pfam PF00695: Major surface antigen from hepadnavirus (family)
This entry represents the large envelope protein S from hepatitis B virus. The large envelope protein exists in two topological conformations, one which is termed 'external' or Le-HBsAg and the other 'internal' or Li-HBsAg. In its external conformation the protein attaches the virus to cell receptors and thereby initiating infection. This interaction determines the species specificity and liver tropism. In its internal conformation the protein plays a role in virion morphogenesis and mediates the contact with the nucleocapsid like a matrix protein .