SII-SWORD/CoKE huggingface dataset:
Pfam PF15774: Domain of unknown function (DUF4702) (family)
This family of proteins is found in eukaryotes. Proteins in this family are typically between 346 and 637 amino acids in length.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF13679: Methyltransferase domain (domain)
This family appears to be a methyltransferase domain.
Pfam PF15271: Spindle pole body component BBP1, Mps2-binding protein (family)
This N-terminal domain of BBP1, a spindle pole body component, interacts directly, though transiently, with the polo-box domain of Cdc5p. full length BBP1 localises at the cytoplasmic side of the central plaque periphery of the spindle pole body (SPB) and plays an important role in inserting a duplication plaque into the nuclear envelope and assembling a functional inner plaque. Although not a membrane protein itself, BBP1 binds to Mps2 as well as to Spc29 and the half-bridge protein Kar1, thus providing a model for how the SPB core is tethered within the nuclear envelope and to the half-bridge.
Pfam PF01887: SAM hydroxide adenosyltransferase N-terminal domain (domain)
This is a family of proteins, previously known as DUF62, found in archaebacteria and bacteria. The structure of proteins in this family is similar to that of a bacterial fluorinating enzyme. S-adenosyl-l-methionine hydroxide adenosyltransferases utilises a rigorously conserved amino acid side chain triad (Asp-Arg-His) which may have a role in activating water to hydroxide ion. This family used to be known as DUF62.
Pfam PF06097: Bacterial protein of unknown function (DUF945) (family)
This family consists of several hypothetical bacterial proteins of unknown function.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF04609: Methyl-coenzyme M reductase operon protein C (family)
Methyl coenzyme M reductase (MCR) catalyses the final step in methanogenesis. MCR is composed of three subunits, alpha ([pfam:PF02249]), beta ([pfam:PF02241]) and gamma ([pfam:PF02240]). Genes encoding the beta (mcrB) and gamma (mcrG) subunits are separated by two open reading frames coding for two proteins C and D. The function of proteins C and D (this family) is unknown. This family nowalso includes family MtrC_related,
Pfam PF23558: Prolyl 4-hydroxylase peptide-substrate-binding domain (repeat)
This entry represents the prolyl 4-hydroxylase peptide substrate binding domain, which is formed by two and a half TPR-like repeats.  The P4HA family is responsible for the post-translational hydroxylation of proline residues in -Xaa-Pro-Gly- sequences, which is a critical step in the biosynthesis of collagens and other proteins. This modification by the P4HA enzymes enhances the stability of collagen by facilitating the formation of hydrogen bonds within the triple helical structure of collagen fibers. The hydroxylation of proline residues to 4-hydroxyproline is essential for maintaining the structural integrity of collagen and ensuring proper function of the extracellular matrix where these proteins are predominantly found.
Pfam PF04874: Mak16 protein C-terminal region (family)
The precise function of this eukaryotic protein family is unknown. The yeast orthologues have been implicated in cell cycle progression and biogenesis of 60S ribosomal subunits. The Schistosoma mansoni Mak16 has been shown to target protein transport to the nucleolus.
Pfam PF12483: E3 Ubiquitin ligase (family)
This domain family is found in bacteria, archaea and eukaryotes, and is typically between 150 and 163 amino acids in length. There is a single completely conserved residue E that may be functionally important. GIDE is an E3 ubiquitin ligase which is involved in inducing apoptosis.
Pfam PF17991: Thioredoxin like C-terminal domain (domain)
This is the C-terminal thioredoxin like domain found in Rv2874 in the pathogenic bacterium Mycobacterium tuberculosis. Structure analysis of Rv2874-C shows the presence of a C-terminal domain formed by the 128 residues Thr568-Gly695. These residues form a jelly-roll structure in which two antiparallel beta-sheets sandwich a hydrophobic core. This domain is combined with a second domain with a carbohydrate-binding module (CBM) fold.
Pfam PF12887: SICA extracellular alpha domain (domain)
The SICA (schizont-infected cell agglutination) proteins of P. knowlesi, one of the variant antigen gene families, are associated with parasitic virulence. These proteins are comprised of multiple domains, with the extracellular domains occurring at different frequencies.  This domain is typically found at the N-terminus, with 1 or 2 copies per protein.  The domain is cysteine-rich domain  and similar to PFAM:PF12878.
Pfam PF18452: Immunoglobulin domain (domain)
This is an immunoglobulin domain which can be found in Interleukin-18 receptor alpha (IL-18Ra).  IL-18Ra ectodomain folds into three immunoglobulin (Ig)-like domains, similar to IL-1 receptors. Each domain comprises a two-layer sandwich of six to nine beta-strands and contains at least one intra-domain disulfide bond.
Pfam PF21343: ACAD9/ACADV, C-terminal domain (domain)
Acyl-CoA dehydrogenases catalyse the alpha,beta-dehydrogenation of acyl-CoA thioesters to the corresponding trans 2,3-enoyl CoA-products with reduction of enzyme-bound FAD. They consist of an N-terminal all-alpha domain, a middle open (5,8) barrel domain and a four-helical bundle C-terminal domain. Members of the acyl-CoA dehydrogenase family differ in the number of C-terminal domains. This entry represents the second C-terminal domain, from ACAD9 and Very long-chain specific acyl-CoA dehydrogenase (ACADV).
Pfam PF24714: TORTIFOLIA1 N-terminal (repeat)
This entry includes a group of plant microtubule-associated proteins, including TORTIFOLIA1/SPIRAL2 and SPIRAL2-like (SP2L) from Arabidopsis. They regulate the orientation of cortical microtubules and the direction of organ growth. TORTIFOLIA1-like protein 1 (also known as SPIRAL2) may regulate katanin-based microtubule (MT) severing. During virus infection, it may stabilize MT crossovers to support the formation and intercellular spread of the viral RNA complexes. This entry represents a domain found at the N-terminal of TORTIFOLIA1 and related sequences such as SINE1/2, which function during stomatal dynamics induced by light-dark transitions and abscisic acid (ABA), that requires F-actin reorganisation.
Pfam PF24791: SAC9 C8D domain (domain)
This domain is found in the SAC9 protein from Arabidopsis thaliana which is a probable phosphoinositide phosphatase that is involved in modulating phosphoinositide signals during the stress response. This domain contains four pairs of highly conserved cysteine residues that are probably involved in metal coordination.
Pfam PF07729: FCD domain (domain)
This domain is the C-terminal ligand binding domain of many members of the GntR family. This domain binds to a range of effector molecules, including Lactate, Zn(II), Ni(II), Ca(II), Mg(II), citrate, sugar acids, sialic acid and N-acetylglucosamine-6-P, that regulate the transcription of genes through the action of the N-terminal DNA-binding domain [pfam:PF00392] (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043). This domain is found in [swissprot:P45427] and [swissprot:P31460] that are regulators of sugar biosynthesis operons. It is also in the known structure of FadR where it binds to acyl-coA, the domain is alpha helical. This family has been named as FCD for (FadR C-terminal Domain).
Pfam PF08874: Domain of unknown function (DUF1835) (domain)
This family of proteins are functionally uncharacterised.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF15345: Transmembrane protein 51 (family)
This family of proteins is found in eukaryotes. Proteins in this family are typically between 233 and 253 amino acids in length.
Pfam PF24018: Family of unknown function (DUF7331) (family)
This entry represents uncharacterised archaeal proteins. They share a semi-conserved YDxxNPXAW sequence motif.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF22959: NUP210 Ig-like domain 15 (domain)
This domain is found in the homologues of Nuclear pore membrane glycoprotein 210 (NUP210). NUP210 is essential for nuclear pore assembly and fusion, nuclear pore spacing, as well as for its structural integrity. NUP210 is composed of multiple immunoglobin-like (Ig-like) domains and forms a ring around the NPC within the NE lumen. The domain represented by this entry is one of these constituent Ig-like domains and has a significant structural similarity to cadherin domains.
Pfam PF10364: Putative capsular polysaccharide synthesis protein (family)
Found only in Vibrio species, pombe and one other fungi, this is a the N-terminal 150 residues of a family of proteins of unknown function.              There is a characteristic NKWYS sequence motif.
Pfam PF07338: YdgH/BhsA/McbA-like domain (domain)
This domain is found in several Enterobacterial proteins of around 90 residues in length, including E. coli YdgH, YhcN, BhsA and McbA, which play a role in stress response, biofilm formation and pathogenesis. BhsA (also known as ComC) reduces the permeability of the outer  membrane to copper and may decrease biofilm formation by repressing cell-cell interaction and cell surface interaction. Members of this entry have one copy of this domain with the exception of YdgH, which has three copies. The function of this domain is unknown, however, it is suggested to be directly involved in host-pathogen interaction.
Pfam PF24959: FHOD1/3 FH3 domain (repeat)
This is the FH3 domain of formin proteins, such as FH1/FH2 domain-containing proteins 1 and 3 from human. FHOD1 is required for the assembly of F-actin structures, such as stress fibers and depends on the Rho-ROCK cascade for its activity. It contributes to the coordination of microtubules with actin fibers and plays a role in elongation. This domain consists of armadillo repeats and mediates the interactions with spectrin repeat 12 (SR12) from Nesprin.
Pfam PF00351: Biopterin-dependent aromatic amino acid hydroxylase (domain)
This family includes phenylalanine-4-hydroxylase, the phenylketonuria disease protein.
Wikipedia: Biopterin-dependent aromatic amino acid hydroxylases (AAAH) are a family of aromatic amino acid hydroxylase enzymes which includes phenylalanine 4-hydroxylase, tyrosine 3-hydroxylase, and tryptophan 5-hydroxylase. These enzymes primarily hydroxylate the amino acids L-phenylalanine, L-tyrosine, and L-tryptophan, respectively.
Pfam PF15912: Virilizer, N-terminal (family)
VIR_N is the conserved N-terminus of the protein virilizer, necessary for male and female viability and required for the production of eggs capable of embryonic development.
Pfam PF22312: SgrA, immunoglobulin-like (domain)
This entry represents a Immunoglobulin-like domain present in the Serine-glutamate repeat protein A (SgrA), also known as LPXTG family cell surface protein Fms2.
Pfam PF03371: PRP38 family (family)
Members of this family are related to the pre mRNA splicing factor PRP38 from yeast.  Therefore all the members of this family could be involved in splicing.  This conserved region could be involved in RNA binding. The putative domain is about 180 amino acids in length. PRP38 is a unique component of the U4/U6.U5 tri-small nuclear ribonucleoprotein (snRNP) particle and is necessary for an essential step late in spliceosome maturation.
Pfam PF11029: DAZ associated protein 2 (DAZAP2) (family)
DAZ associated protein 2 has a highly conserved sequence throughout evolution including a conserved polyproline region and several SH2/SH3 binding sites. It occurs as a single copy gene with a four-exon organisation and is located on chromosome 12. It encodes a ubiquitously expressed protein and binds to DAZ and DAZL1 through DAZ repeats.
Pfam PF03038: UL95 family (family)
Members of this family, found in several herpesviruses, include EBV BGLF3 [swissprot:P03220] and other UL95 proteins (e.g. HCMV UL95 [swissprot:P16801],  HVS-1 34 [swissprot:Q01023], HSV6 U67 [swissprot:P24444]). Their function is unknown.
Pfam PF24443: Family of unknown function (DUF7562) (family)
This entry represents a small family of uncharacterised proteins found in archaea. They contain two pairs of conserved cysteines that are likely involved in metal coordination. These proteins are predicted to structurally resemble treble-clef zinc fingers.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF09617: CRISPR-associated protein GSU0053 (Cas_GSU0053) (family)
This entry is found in CRISPR-associated (cas) proteins in the genomes of Geobacter sulfurreducens PCA and Desulfotalea psychrophila LSv54 (both Desulfobacterales from the Deltaproteobacteria), Gemmata obscuriglobus (a Planctomycete), and Actinomyces naeslundii MG1 (Actinobacteria).
Pfam PF18815: Bacterial antifreeze protein repeat (repeat)
This family of proteins is involved in stopping the formation of ice crystals at low temperatures. The structure folds as a Ca(2+)-bound  parallel beta-helix with an extensive array of ice-like surface  waters that are anchored via hydrogen bonds directly to the  polypeptide backbone and adjacent side chains.
Pfam PF01513: ATP-NAD kinase N-terminal domain (domain)
Members of this family include ATP-NAD kinases [ec:2.7.1.23], which catalyses the phosphorylation of NAD to NADP utilising ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus. Also includes NADH kinases [ec:2.7.1.86].
Pfam PF05323: Poxvirus A21 Protein (family)
This family consists of several poxvirus A21 proteins.
Pfam PF14831: Domain of unknown function (DUF4484) (domain)
This domain is found, in a few members, a the the C-terminus of family Avl9, [pfam:PF09794]. The function is not known.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF12165: Alfin (family)
The Alfin family includes PHD finger protein Alfin1 and Alfin1-like proteins. Alfin1 is a histone-binding component that specifically recognises H3 tails trimethylated on 'Lys-4' (H3K4me3), which marks transcription start sites of virtually all active genes.
Pfam PF02289: Cyclohydrolase (MCH) (domain)
Methenyl tetrahydromethanopterin cyclohydrolase [ec:3.5.4.27] is involved in methanogenesis in bacteria and archaea, producing methane from  carbon monoxide or carbon dioxide.
Pfam PF07156: Prenylcysteine lyase (family)
This family contains prenylcysteine lyases ([ec:1.8.3.5]) that are approximately 500 residues long. Prenylcysteine lyase is a FAD-dependent thioether oxidase that degrades a variety of prenylcysteines, producing free cysteine, an isoprenoid aldehyde and hydrogen peroxide as products of the reaction. It has been noted that this enzyme has considerable homology with ClP55, a 55 kDa protein that is associated with chloride ion pumps.
Pfam PF22880: Family of unknown function (DUF7019) (family)
This is a family of uncharacterised proteins found mainly in actinomycetes. Their function is unknown. They are predicted to adopt OB fold with significant similarity to Rpa.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF14775: Sperm tail C-terminal domain (domain)
NYD-SP28 is expressed in a development-dependent manner, localised in spermatogenic cell cytoplams and human spermatozoa tail.  It is post-translationally modified during sperm capacitation and ultimately contributes to the success of fertilisation. This short region is found at the very C-terminus of family members of family NYD-SP28, [pfam:PF14772].
Pfam PF22800: CFAP410 C-terminal domain (domain)
This entry represents the C-terminal domain of Trypanosoma brucei cilia and flagella associated protein 410 (CFAP410) and related proteins. This domain is involved in oligomerisation and self-associates to form a tetrameric helical bundle composed of a dimer of two interlocking dimers.
Pfam PF24723: Family of unknown function (DUF7675) (domain)
This entry represents an uncharacterised family of proteins is found in bacteria and viruses. Proteins in this family are typically between 69 and 93 amino acids in length.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF20493: Fungal WD-like (family)
This is an uncharacterised family of proteins found in Fungi, present in S. japonicus but seems to be absent in S. pombe and S. cerevisiae. It may be a divergent WD repeat-like family of proteins. There are eight conserved cysteine residues.
Pfam PF06339: Ectoine synthase (family)
This family consists of several bacterial ectoine synthase proteins. The ectABC genes encode the diaminobutyric acid acetyltransferase (EctA), the diaminobutyric acid aminotransferase (EctB), and the ectoine synthase (EctC). Together these proteins constitute the ectoine biosynthetic pathway.
Pfam PF24880: Domain of unknown function (DUF7738) (domain)
This entry represents a family of uncharacterised bacterial protein domains. The structure of these proteins shows some structural similarity to the PePSy domain.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF02132: RecR, Cys4-zinc finger domain (domain)
The bacterial protein RecR is an important regulator in the RecFOR homologous recombination pathway during DNA repair. It acts with RecF and RecO forming a complex that facilitates the loading of RecA onto ssDNA. RecR is a zinc metalloprotein consisting of a N-terminal helix-hairpin-helix (HhH) motif, a middle region containing a zinc finger motif and a Toprim domain ([pfam:PF13662]) and a C-terminal domain comprising a Walker B motif and a C-terminal helix. This is the zinc finger motif, which consists of four strictly conserved cysteine residues which coordinate a zinc ion. This motif is the most conserved domain in RecR proteins and plays a structural role stabilizing the 3D structure of the protein.
Pfam PF11121: Protein of unknown function (DUF2639) (family)
This family is conserved in the Bacillaceae family.  Several members are named as being YflJ, but the function is not known.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF13835: Domain of unknown function (DUF4194) (family)
This family includes Wadjet protein JetB, a component of anti plasmid transformation system Wadjet type I, composed of JetA, JetB, JetC and JetD. Expression of Wadjet type I in B.subtilis (strain BEST7003) reduces the transformation efficiency of plasmid pHCMC05 .
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF11642: Mite allergen Blo t 5 (domain)
This family of proteins is Blo t 5, an allergen protein from Blomia tropicalis mites. This protein shoes strong reactivity with IgE in asthmatic and rhinitis patients.
Pfam PF15818: Coiled-coil domain-containing protein 73 family (coiled_coil)
CCDC73 is a family of eukaryotic coiled-coil containing proteins. The function is not known. The alternative name is sarcoma antigen NY-SAR-79.
Pfam PF05606: Borrelia burgdorferi protein of unknown function (DUF777) (family)
This family consists of several hypothetical proteins of unknown function from Borrelia burgdorferi (Lyme disease spirochete).
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF02195: ParB/Sulfiredoxin domain (family)
Proteins containing this domain include Escherichia coli plasmid protein ParB and mammalian Sulfiredoxin-1. ParB is involved in chromosome partition. It localises to both poles of the predivisional cell following completion of DNA replication. Sulfiredoxin-1 contributes to oxidative stress resistance by reducing cysteine-sulfinic acid formed under exposure to oxidants in the peroxiredoxins PRDX1, PRDX2, PRDX3 and PRDX4.