SII-SWORD/CoKE huggingface dataset:
Pfam PF08683: Microtubule-binding calmodulin-regulated spectrin-associated (domain)
This is the C-terminal domain of a family of eumetazoan proteins collectively defined as calmodulin-regulated spectrin-associated, or CAMSAP, proteins. CAMSAP proteins carry an N-terminal region that includes the CH domain, a central region including a predicted coiled-coil and this C-terminal, or CKK, domain - defined as being present in CAMSAP, KIAA1078 and KIAA1543, The C-terminal domain is the part of the CAMSAP proteins that binds to microtubules. The domain appears to act by producing inhibition of neurite extension, probably by blocking microtubule function. CKK represents a domain that has evolved with the metazoa. The structure of a murine hypothetical protein from RIKEN cDNA has shown the domain to adopt a mainly beta barrel structure with an associated alpha-helical hairpin.
Wikipedia: In molecular biology, the calmodulin-regulated spectrin-associated CKK domain is a domain which occurs at the C-terminus of a family of eumetazoan proteins collectively defined as calmodulin-regulated spectrin-associated, or CAMSAP, proteins. CAMSAP proteins carry an N-terminal region that includes the CH domain, a central region including a predicted coiled-coil and this C-terminal. This domain is the part of the CAMSAP proteins that binds to microtubules. The domain appears to act by producing inhibition of neurite extension, probably by blocking microtubule function. CKK represents a domain that has evolved with the metazoa. The structure of this domain in murine hypothetical protein has shown the domain to adopt a mainly beta barrel structure with an associated alpha-helical hairpin.
Pfam PF11272: Protein of unknown function (DUF3072) (family)
This bacterial family of proteins has no known function.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF15225: Interleukin 32 (family)
This entry represents interleukin-32, it is a proinflammatory cytokine with a folding structure that does not resemble that of any classical cytokine . It may have a role in a range of diseases, including infections, chronic inflammation, and cancer .
Wikipedia: Interleukin 32 (IL32) is proinflammatory cytokine that in humans is encoded by the IL32 gene. Interleukin 32 can be found in higher mammals but not in rodents. It is mainly expressed intracellularly and the protein has nine different isoforms, because the pre-mRNA can be alternatively spliced. The most active and studied isoform is IL-32γ. It was first reported in 2005, although the IL-32 gene was first described in 1992. It does not belong to any cytokine family because there is almost no homology with other cytokines.
Pfam PF24912: TNRC18-like,(4.1.1) SH3 (domain)
This domain is found immediately N-terminal to the Tudor domain ([pfam:PF21744]) in human Trinucleotide repeat-containing gene 18 protein (TNRC18), a chromatin regulator that recognises histone H3 lysine 9 to mediate the silencing of endogenous retroviruses class I.
Pfam PF14923: Coiled-coil protein 142 (coiled_coil)
The function of this coiled-coil domain-containing family is not known. It is found in eukaryotes.
Pfam PF19012: Family of unknown function (DUF5741) (coiled_coil)
This coiled-coil is found in various Platyhelminthes, with many of the sequences annotated as being uveal autoantigen with coiled-coil. This region is one of the numerous coiled-coil regions which constitutes this antigen. The function is currently unknown.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF00297: Ribosomal protein L3 (family)
Ribosomal protein L3 (also known as uL3) is one of the proteins from the large ribosomal subunit. In Escherichia coli, L3 is known to bind to the 23S rRNA and may participate in the formation of the peptidyltransferase centre of the ribosome.
Pfam PF18921: Cyanophycin synthase-like N-terminal domain (domain)
This domain is found at the N-terminus of cyanophycin synthase proteins and related enzymes from bacteria and archaea. It is approximately 120 amino acids in length. The family is found in association with [pfam:PF08245], [pfam:PF02875]. This domain is found in isolation in some proteins.
Pfam PF07410: Streptococcus thermophilus bacteriophage Gp111 protein (family)
This family consists of several Streptococcus thermophilus bacteriophage Gp111 proteins of around 110 residues in length. The function of this family is unknown.
Pfam PF04893: Yip1 domain (domain)
The Yip1 integral membrane domain contains four transmembrane alpha helices. The domain is characterised by the motifs DLYGP and GY. The Yip1 protein is a golgi protein involved in vesicular transport that interacts with GTPases.
Pfam PF12923: Ribosomal RNA-processing protein 7 (RRP7) C-terminal domain (domain)
RRP7 is an essential protein in yeast that is involved in pre-rRNA processing and ribosome assembly.  It is speculated to be required for correct assembly of rpS27 into the pre-ribosomal particle.
Pfam PF19319: Domain of unknown function (DUF5919) (domain)
This is the C-terminal domain of [pfam:PF18725] domain-containing proteins, whose function is unknown.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF21950: Protein myomixer (family)
This protein family includes human Protein myomixer (MINION), also known as Protein myomerger in mouse, and similar sequences from vertebrates. MINION is an essential skeletal muscle specific microprotein that mediates myoblast fusion, an essential step for the formation of multi-nucleated muscle fibres.
Pfam PF05671: GETHR pentapeptide repeat (5 copies) (repeat)
This pentapeptide repeat is found mainly in Plasmodium spp. The most conserved amino acid at each position leads to its name GETHR (Bateman A unpublished obs.). The function of this repeat is unknown.
Pfam PF10348: Domain of unknown function (DUF2427) (domain)
This is the N-terminal region of a family of proteins conserved in fungi.  Several members are annotated as being Ftp1 but this could not be confirmed. The function is not known.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF19714: Family of unknown function (DUF6209) (family)
This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC00001940) is described by MIBiG as an example of the following biosynthetic class, polyketide. It includes a member from the pyxidicycline A biosynthetic gene cluster from Pyxidicoccus  fallax. This family appears to be predominantly found in  bacteria.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF15266: Domain of unknown function (DUF4594) (family)
This protein family is a domain of unknown function. The protein family is found in eukaryotes, and is typically between 170 and 183 amino acids in length.In humans, the gene encoding this protein lies in the position, chromosome 15 open reading frame 52.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF09095: Alpha-amylase/4-alpha-glucanotransferase, C-terminal (domain)
This entry represents a domain found in prokaryotic alpha-amylase and 4-alpha-glucanotransferase. It adopts a beta-sandwich fold, in which two layers of anti-parallel beta-sheets are arranged in a nearly parallel fashion. The exact function of this family is, as yet, unknown, however it has been proposed that they may play a role in transglycosylation reactions.
Pfam PF04226: Transglycosylase associated protein (family)
Bacterial protein, predicted to be an integral membrane protein. Some family members have been annotated as transglycosylase associated proteins, but no experimental evidence is provided. This family was annotated based on the information in [swissprot:P76011].
Pfam PF19300: Binding-prot-dependent transport system membrane comp, N-term (family)
This is the N-terminal transmembrane domain of the Binding-protein-dependent transport system inner membrane component.
Pfam PF20050: Family of unknown function (DUF6452) (family)
This family of proteins is functionally uncharacterised. This family of proteins is found in Bacteroidetes. Proteins in this family are typically between 159 and 189 amino acids in length. This proteins contain the conserved motifs PL and SxxCG.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF06613: KorB C-terminal beta-barrel domain (domain)
This family consists of several KorB transcriptional repressor proteins. The korB gene is a major regulatory element in the replication and maintenance of broad host-range plasmid RK2. It negatively controls the replication gene trfA, the host-lethal determinants kilA and kilB, and the korA-korB operon. This beta-barrel domain is found at the C-terminus of KorB.
Pfam PF06207: Protein of unknown function (DUF1002) (family)
This protein family has no known function. Its members are about 300 amino acids in length. It has so far been detected in Firmicute bacteria and some archaebacteria.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF07978: NIPSNAP (domain)
Members of this family include many hypothetical proteins.  It also  includes members of the NIPSNAP family which have putative roles in  vesicular transport.  This domain is often found in duplicate.
Pfam PF14425: Immunity protein Imm3 (family)
A predicted Immunity protein, with a mostly all-alpha fold, present  in bacterial polymorphic toxin systems as an immediate gene neighbor  of the toxin gene .
Pfam PF07841: DM4/DM12 family (family)
This family contains sequences derived from hypothetical proteins expressed by two insect species, D. melanogaster and A. gambiae. The region in question is approximately 115 amino acid residues long and contains four highly- conserved cysteine residues.
Pfam PF18683: Chitinase W immunoglobulin-like domain (domain)
This is an immunoglobulin like domain found in ChiW, a chitinase with high activity towards various chitins. ChiW has a multi-modular architecture composed of six domains to function efficiently on the cell surface: a right-handed beta-helix domain (carbohydrate-binding module family 54, CBM-54), a Gly-Ser-rich loop, 1st immunoglobulin-like (Ig-like) fold domain, 1st beta/alpha-barrel catalytic domain (glycoside hydrolase family 18, GH-18), 2nd Ig-like fold domain and 2nd beta/alpha-barrel catalytic domain (GH-18).
Pfam PF22367: Flagellar hook protein FlgE, third domain (domain)
This domain is found in Flagellar hook protein FlgE from the Caulobacter vibrioides and related sequences from Caulobacter. Multiple copies of FlgE form part of the hook, a highly flexible universal joint that connects the filament to the motor of flagella. This protein consists of an N-terminal domain [pfam:PF00460], followed by [pfam:PF22692], the a third domain represented in this entry, [pfam:PF07559] and a C-terminal domain ([pfam:PF06429]). This domain shows beta-strands organised like a rugby ball, that is completed with some long loops.
Pfam PF05129: Transcription elongation factor Elf1 like (domain)
This family of short proteins contains a putative zinc binding domain with four conserved cysteines.  [swissprot:P36053] has been identified as a transcription elongation factor in Saccharomyces cerevisiae.
Pfam PF21811: Rod-determining factor A (family)
This entry represents a family of proteins from halobacteria, including Rod-determining factor A (RdfA) from Haloferax volcanii ([swissprot:D4GVA7]). RdfA is required for the formation of rods under specific growth conditions, and is therefore involved in motility. Members of this family possess four highly conserved cysteine residues at the C-terminus that could potentially be involved in zinc binding.
Pfam PF05771: Poxvirus A31 protein (family)
This family contains the vaccinia virus A31R protein, also known as Protein OPG159, the function of which is not known.
Pfam PF01271: Granin (chromogranin or secretogranin) (family)
Granins (chromogranins or secretogranins)  are a family of acidic proteins present in the secretory granules of a wide variety of endocrine and neuro-endocrine cells. The exact function(s) of these proteins is not yet known but they seem to be the precursors of biologically active peptides and/or they may act as helper proteins in the packaging of peptide hormones and neuropeptides. Apart from their subcellular location and the abundance of acidic residues (Asp and Glu), these proteins do not share many structural similarities. Only one short region, located in the C-terminal section, is conserved in all these proteins, such as:


 * Chromogranin A (CGA): CGA is a protein of about 420 residues; it is the precursor of the peptide pancreastatin which strongly inhibits glucose- induced insulin release from the pancreas.
 * Secretogranin 1 (chromogranin B): A sulfated protein of about 600 residues.
 * Secretogranin 2 (chromogranin C): A sulfated protein of about 650 residues.


Chromogranins and secretogranins together share a C-terminal motif, whereas chromogranins A and B share a region of high similarity in their N-terminal section; this region includes two cysteine residues involved in a disulphide bond.
Wikipedia: Granin is a protein family of regulated secretory proteins ubiquitously found in the cores of amine and peptide hormone and neurotransmitter dense-core secretory vesicles.
Pfam PF18070: CRISPR-Cas9 PI domain (domain)
This domain is found in Cas9 proteins which can be Staphylococcus aureus. Cas9 cleaves double-stranded DNA targets with a protospacer adjacent motif (PAM) and complementarity to the guide RNA. When this domain is combined with the C-terminal domain it is called the Pam-interacting (PI) domain. The Cas9 orthologs from different microbes have highly divergent sequences but their PI domains share a conserved core fold and recognize distinct PAM sequences.
Pfam PF21290: BIRC2/3-like, UBA domain (domain)
Baculoviral IAP repeat-containing proteins, also known as c-IAPs, function as ubiquitin E3 ligases that mediate the ubiquitination of the substrates involved in apoptosis, nuclear factor-kappaB (NF-kappaB) signaling, and oncogenesis. This entry    represents the UBA domain of BIRC2/3/4/8 from mammals and BIRC7 from Xenopus tropicalis.
Pfam PF12378: Mycoplasma adhesin P1, N-terminal (repeat)
This entry represents the N-terminal domain cytadhesin P1 from Mycoplasma. Cytadhesins are virulence factor proteins which mediate attachment of bacterial cells to host cells for invasion. P1 forms a transmembrane complex with P40/P90 called the 'Nap', which mediates motility and infectivity. Structure of P1, revealed that it consists of a large N-terminal domain consisting of seven consecutive beta-sheets each with four antiparallel beta-strands, except for the seventh which has two strands, and adopts a beta-propeller topology. Those two strands correspond to the cytoadherence epitope which has important immune properties. The N-terminal domain is highly variable and described as a structured core surrounded by a fuzzy surface.
Pfam PF07563: Protein of unknown function (DUF1541) (family)
This family consists of several hypothetical bacterial and occurs as a tandem repeat.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF20233: Family of unknown function (DUF6590) (family)
This presumed domain found in Fungi is functionally uncharacterised.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF03168: Late embryogenesis abundant protein (domain)
Different types of LEA proteins are expressed at different stages of late embryogenesis in higher plant seed embryos and under conditions of dehydration stress.  The function of these proteins is unknown.  This family represents a group of LEA proteins that appear to be distinct from those in [pfam:PF02987]. The family DUF1511, [pfam:PF07427], has now been merged into this family.
Pfam PF22728: NACHT C-terminal Helical domain 1 (domain)
This is a helical domain found at the C-terminus of bacterial NACHT conflict systems.
Pfam PF22293: Annexin E1, fourth repeat (domain)
This domain is found at the C-terminal end of Annexin E1 from Giardia intestinalis (ANXE1) and similar sequences predominantly found in lower eukaryotes. ANXE1 may function as a calcium -regulated structural element linking phospholipid bilayer and underlying axoneme. It shows a core domain that consists of four tandem repeats and a a C-terminal extension. This entry represents the fourth repeat, which shows five alpha-helices and forms a module with the first repeat.
Pfam PF22281: Family of unknown function (DUF6959) (family)
This is a family of uncharacterised bacterial proteins. They contain conserved Pro-Gly-rich motif with a semi- conserved pattern PGRxFPGx3QGD.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF00299: Squash family serine protease inhibitor (domain)
The squash inhibitors form one of a number of serine proteinase inhibitor families. They belong to MEROPS inhibitor family I7, clan IE. They are generally annotated as either trypsin or elastase inhibitors (MEROPS peptidase family S1, IPR001254). The proteins, found exclusively in the seeds of the cucurbitaceae, e.g. Citrullus lanatus (watermelon), Cucumis sativus (cucumber), Momordica charantia (balsam pear), are approximately 30 residues in length and contain 6 Cys residues, which form 3 disulphide bonds . The inhibitors function by being taken up by a serine protease (such as trypsin), which cleaves the peptide bond between Arg/Lys and Ile residues in the N-terminal portion of the protein . Structural studies have shown that the inhibitor has an ellipsoidal shape, and is largely composed of Î²-turns . The fold and Cys connectivity of the proteins resembles that of potato carboxypeptidase A inhibitor .
Pfam PF16305: Domain of unknown function (DUF4947) (family)
This small family consists of uncharacterized proteins around 220 residues in length and is mainly found in various Streptococcus mutans species. The function of this family is unknown.
Pfam PF05403: Plasmodium histidine-rich protein (HRPII/III) (disordered)
This family consists of several histidine-rich protein II and III sequence from Plasmodium falciparum.
Pfam PF00428: 60s Acidic ribosomal protein (family)
This family includes archaebacterial L12, eukaryotic P0, P1 and P2.
Pfam PF07403: Protein of unknown function (DUF1505) (family)
This family consists of several uncharacterised Caenorhabditis elegans proteins of around 115 resides in length. Members of this family contain 6 highly conserved cysteine residues. The function of this family is unknown.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF22658: YycE-like N-terminal domain (domain)
This entry represents a VOC-like domain found at the N-terminal of a group of uncharacterised bacterial sequences, such YycE from Bacillus subtilis.
Pfam PF20901: Bacteriophage Sf6, terminase small subunit-like (family)
In many tailed double-stranded DNA (dsDNA) virus such as Bacteriophage Sf6, the DNA newly synthesized is packaged into a preformed procapsid. The small subunit of the terminase is the component responsible for concatemeric viral DNA-recognition in the molecular machine that carries out this process. The small subunit of the terminase from phage Sf6, also known as gp1, consists of an N-terminal domain, a central alpha-helical domain and a C- terminal domain forming a beta-barrel, and adopts a ring-like octameric configuration composed of monomers.