SII-SWORD/CoKE huggingface dataset:
Pfam PF23488: YKL065W-A (family)
This protein family includes the uncharacterised protein YKL065W-A from Saccharomyces cerevisiae, a micropeptide encoded by a small open reading frame (smORF).
Pfam PF22393: MLPTv-like, helix-turn-helix domain (domain)
This entry represents a winged helix-turn-helix (wHTH) domain present in MLPTv (MarR-like protein from Thermoplasma volcanium).
Pfam PF20715: Domain of unknown function (DUF6827) (domain)
This presumed domain is functionally uncharacterised. This domain is predominantly found in sequences from Apicomplexa. There are highly conserved motifs: NWxD, EDxxDH and GxGLAI/LLRQ.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF20145: ARMET, N-terminal (domain)
This is the N-terminal domain of ARMET proteins (also known as mesencephalic astrocyte-derived neurotrophic factor (MANF) or arginine-rich protein), a saposin-like domain consisting of five alpha-helices with three cystein bridges that stabilises the globular "closed leaf" conformation. ARMET is a small protein of approximately 170 residues which contain four di-sulfide bridges that are highly conserved from nematodes to humans. It is a soluble protein resident in the endoplasmic reticulum and induced by ER stress. It appears to be involved with dealing with mis-folded proteins in the ER, thus in quality control of ER stress.
Pfam PF18130: ATP-grasp N-terminal domain (domain)
This is the N-terminal domain found in BL00235 present in Bacillus licheniformis. BL00235 is a ATP-grasp superfamily protein that catalyzes the formation of an alpha-peptide bond between two L-amino acids in an ATP-dependent manner. BL00235 has a highly restricted substrate specificity: the N-terminal substrate is confined to L-methionine an L-leucine, while the C-terminal substrates include small residues such as L-alanine, L-serine, L-threonine and L-cysteine.
Pfam PF19879: Family of unknown function (DUF6352) (family)
This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 340 amino acids in length.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF22527: DEXQ-box helicase domain of Suv3 (domain)
This entry represents the DEXQ-box helicase domain of Suv3.
Pfam PF15108: Voltage-dependent calcium channel gamma-like subunit protein family (family)
This family of transmembrane proteins, TMEM37, has a role in stabilising the calcium channel in an inactivated (closed) state. It is a subunit of the L-type calcium channels. This family of proteins are found in eukaryotes. Proteins in this family are approximately 210 amino acids in length.
Pfam PF24047: Krimper first tudor domain (domain)
This entry represents the first Tudor domain found in krimper protein from insects. Krimper is required for ping-pong piRNA amplification and is capable of both self-interactions and binding of the two PIWI proteins: Aub and Ago3. The ping-pong cycle is a process where the degradation of complementary target mRNA by PIWI proteins can trigger the generation of new RNA guides for the repression of transposable elements proliferation. This domain is found in a region of the protein involved in the interaction and binding to Ago3, but not Aub.
Pfam PF16647: Granulocyte colony-stimulating factor (domain)
GCSF is a family of higher eukaryotic granulocyte colony-stimulating factor proteins. Granulocyte colony-stimulating factors are cytokines that are involved in haematopoeisis.  They control the production, differentiation and function of white blood cell granulocytes. GCSF binds to the extracellular Ig-like and CRH domain of its receptor GCSFR, thereby triggering the receptor to homodimerise. Homodimerisation result in activation of Janus tyrosine kinase-signal transducers and other activators of transcription (JAK-STAT)-type signalling cascades.
Pfam PF25084: EIF2B subunit epsilon LbH domain (repeat)
This entry represents the central Left-handed parallel beta-Helix (LbH) domain of Translation initiation factor eIF-2B subunit epsilon (EIF2B), a guanine nucleotide-exchange factor that mediates the exchange of GDP (bound to initiation factor eIF2) for GTP, generating active eIF2-GTP complex. EIF2B is a complex multimeric protein consisting of five subunits, alpha, beta, gamma, delta, epsilon.
Pfam PF00796: Photosystem I reaction centre subunit VIII (family)
Oxygenic photosynthesis uses two multi-subunit photosystems (I and II) located in the cell membranes of cyanobacteria and in the thylakoid membranes of chloroplasts in plants and algae. Photosystem II (PSII) has a P680 reaction centre containing chlorophyll 'a' that uses light energy to carry out the oxidation (splitting) of water molecules, and to produce ATP via a proton pump. Photosystem I (PSI) has a P700 reaction centre containing chlorophyll that takes the electron and associated hydrogen donated from PSII to reduce NADP+ to NADPH. Both ATP and NADPH are subsequently used in the light-independent reactions to convert carbon dioxide to glucose using the hydrogen atom extracted from water by PSII, releasing oxygen as a by-product .
This entry represents subunit VIII (PsaI) of the photosystem I (PSI) reaction centre. PSI is located, along with photosystem II (PSII), in the thylakoid photosynthetic membranes of plants, green algae and cyanobacteria. The crystal structure of PSI from the thermophilic cyanobacterium Synechococcus elongatus (Thermosynechococcus elongatus) has 12 protein subunits and 127 cofactors comprising 96 chlorophylls, 2 phylloquinones, 3 4Fe4S clusters, 22 carotenoids, 4 lipids, and a putative calcium ion . PsaI consists of a single transmembrane helix, and has a crucial role in aiding normal structural organisation of PsaL within the PSI complex and the absence of PsaI alters PsaL organisation, leading to a small, but physiologically significant, defect in PSI function . PsaL encodes a subunit of PSI and is necessary for trimerisation of PSI. PsaL may constitute the trimer-forming domain in the structure of PSI .
Wikipedia: Sea anemone neurotoxin is the name given to neurotoxins produced by sea anemones with related structure and function.
Sea anemone neurotoxins can be divided in two functional groups that either specifically target the sodium channel or the potassium channel.
Pfam PF00037: 4Fe-4S binding domain (domain)
Superfamily includes proteins containing  domains which bind to iron-sulfur clusters. Members  include bacterial ferredoxins, various dehydrogenases, and various reductases.  Structure of the domain is an alpha-antiparallel beta sandwich.
Wikipedia: 
Ferredoxins are iron–sulfur proteins that mediate electron transfer in a range of metabolic reactions. The term "ferredoxin" was coined by D.C. Wharton of the DuPont Co. and applied to the "iron protein" first purified in 1962 by Mortenson, Valentine, and Carnahan from the anaerobic bacterium Clostridium pasteurianum.
Pfam PF20699: Domain of unknown function (DUF6820) (domain)
This domain is functionally uncharacterised. It is found in eukaryotes (predominantly in the marine diatom Thalassiosira) and is approximately 50 amino acids in length. There are several conserved motifs: TSAGR/QARxM, FAV and DNxGRRAM/IG.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF16663: Unstructured region on MAGI (disordered)
MAGI_u3 is a region of natively unstructured but highly conserved sequence on a subset, of higher eukaryote, membrane-associated guanylate kinase with WW and PDZ domain-containing proteins. The function is not known.
Pfam PF06800: Sugar transport protein (family)
This is a family of bacterial sugar transporters approximately 300 residues long. Members include glucose uptake proteins, ribose transport proteins, and several putative and hypothetical membrane proteins probably involved in sugar transport across bacterial membranes. These members are transmembrane proteins which are usually 5+5 duplications. This model recognises a set of five TMs,
Pfam PF18296: MID domain of medPIWI (domain)
MID domain of the medPIWI PIWI/Argonaute module. medPIWI is the core globular domain of the Med13 protein. Med13 is one member of the CDK8 subcomplex of the Mediator transcriptional coactivator complex. The medPIWI module in Med13 is predicted to bind double-stranded nucleic acids, triggering the experimentally-observed conformational switch in the CDK8 subcomplex which regulates the Mediator complex.
Pfam PF06155: Gamma-butyrobetaine hydroxylase-like, N-terminal (domain)
This domain is found in several proteins including gamma-butyrobetaine dioxygenase, Fe-S cluster assembly factor HCF101  and trimethyllysine dioxygenase proteins. Gamma-butyrobetaine  hydroxylase (GBBH) is a alpha-ketoglutarate-dependent dioxygenase  that catalyzes the biosynthesis of L-carnitine by hydroxylation of gamma-butyrobetaine (GBB). GBBH is a dimeric enzyme. The monomer consists of a catalytic double-stranded beta-helix domain and a smaller N-terminal domain. The N-terminal domain has a bound Zn ion,  which is coordinated by three cysteines and one histidine. The  N-terminal domain could facilitate dimer formation, but its precise  function is not known. Other family members have been suggested  to be involved in FeS cluster maintenance (see Supplementary note 5  in.)
Pfam PF23055: Domain of unknown function (DUF7041) (domain)
This is a domain of unknown function predominantly found at the N-terminal of sequences from ticks, spiders and similar sequences from arthropods. According to structure predictions this domain may adopt a alpha-helical bundle fold similar to Ty3 transposon capsid-like proteins.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF20195: Phage tail protein N-terminal domain (domain)
This family includes uncharacterised proteins from Firmicutes and phages, some members are phage tail-related proteins. Included in this entry is the prophage-derived protein YomH from Bacillus subtilis (swiss:O31977). This entry contains a RIFT-related beta barrel domain.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF17506: Family of unknown function (DUF5438) (family)
This is a family of unknown function found in Orthopoxvirus.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF12644: Protein of unknown function (DUF3782) (family)
This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and archaea. Proteins in this family are typically between 91 and 186 amino acids in length.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF16895: Domain of unknown function (DUF5085) (family)
This protein is believed to be involved in the type VII secretion system.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF12918: TcdB toxin N-terminal helical domain (domain)
This is a short helical bundle domain found associated with the catalytic domain of the TcdB toxin from C. difficile. The function of this domain is unknown, but it may be involved in substrate recognition.
Wikipedia: Clostridioides difficile toxin B (TcdB) is a cytotoxin produced by the bacteria Clostridioides difficile. It is one of two major kinds of toxins produced by C. difficile, the other being a related enterotoxin. Both are very potent and lethal.
Pfam PF06547: Protein of unknown function (DUF1117) (family)
This family represents the C-terminus of a number of hypothetical plant proteins.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF22578: Geranylgeranyl reductase catalytic domain (domain)
This entry represents the catalytic domain of archaeal geranylgeranyl reductases (GGR). This domain contains the PxxYxWxFP sequence motif, which defines a specificity pocket in the structure, providing a structural basis for the substrate specificity of GGRs.
Pfam PF20329: Family of unknown function (DUF6624) (family)
This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 188 and 316 amino acids in length.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF12246: Temperature dependent protein affecting M2 dsRNA replication (family)
This domain family is found in eukaryotes, and is typically between 231 and 255 amino acids in length. There is a single completely conserved residue P that may be functionally important. MKT1 is required for maintenance of K2 toxin above 30 degrees C in strains with the L-A-HN variant of the L-A double-stranded RNA virus of Saccharomyces cerevisiae. MKT1 is a 93 kDa protein with serine-rich regions and the retroviral protease signature, DTG. This family is the C terminal region of MKT1.
Pfam PF24197: Family of unknown function (DUF7422) (family)
This entry represents a small family of phage proteins. The family includes members from Phage T2 and T6. These proteins contain a small three stranded beta domain. Some members have an additional small C-terminal domain composed of a beta-alpha-alpha-beta hairpin domain.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF02485: Core-2/I-Branching enzyme (family)
This is a family of two different beta-1,6-N-acetylglucosaminyltransferase enzymes, I-branching enzyme (eg [swissprot:Q06430]) and core-2 branching enzyme (eg [swissprot:Q02742]).  I-branching enzyme is responsible for the production of the blood group I-antigen during embryonic development. Core-2 branching enzyme forms crucial side-chain branches in O-glycans. This is a fmmily of glycosyl-transferases that are Type II membrane proteins that are found in the endoplasmic reticulum (ER) and Golgi apparatus.
Pfam PF24333: Family of unknown function (DUF7501) (family)
This entry represents a group of uncharacterised proteins found in Halobacteria. They contain three invariant cysteine residues and a histidine that probably constitute a metal binding site. These proteins are probably C2HC zinc fingers that are variant of the classical C2H2 zinc finger domains.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF15557: CAF1 complex subunit p150, region binding to PCNA (domain)
CAF1-p150_N is part of the N-terminus of the CAF1 complex p150 subunit that binds to PCNA - proliferating cell nuclear antigen. The PCNA mediates the connection between CAF-1 and the DNA replication fork. The CAF1 complex is essential in human cells for the de novo deposition of histones H3 and H4 at the DNA replication fork.
Pfam PF08456: Viral methyltransferase C-terminal (family)
This domain is found to the C-terminus of the viral methyltransferase domain ([pfam:PF01660]) in single-stranded-RNA positive-strand viruses with no DNA stage in the Virgaviridae family.
Pfam PF12062: Heparan sulfate-N-deacetylase, deacetylase domain (domain)
This entry includes heparan sulfate N-deacetylase enzymes and it represents the deacetylase domain which has a fold closely related to the CE domain of Agd3 from A. fumigatus.
Pfam PF01884: PcrB family (domain)
This family contains proteins that are related to PcrB [swissprot:Q53726]. The function of these proteins is unknown.
Pfam PF20105: Family of unknown function (DUF6495) (family)
This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 160 amino acids in length.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF18916: Lycopene cyclase (domain)
This domain is often repeated twice within the same polypeptide, as is observed in Archaea, Thermus, Sphingobacteria  and Fungi. In the fungal sequences, this tandem domain pair is observed as the N-terminal half of a bifunctional protein , where it has been characterised as a lycopene beta-cyclase and the C-terminal half is a phytoene synthetase. In Myxococcus and Actinobacterial genomes this domain appears as a single polypeptide, tandemly repeated and usually in a genomic context consistent with a role in carotenoid biosynthesis. One member of this family has been annotated as a lycopene beta-cyclase . The domain is generally hydrophobic with a number of predicted membrane spanning segments and contains a distinctive motif (hPhEEhhhhhh). In certain sequences one of either the proline or glutamates may vary, but always one of the tandem pair appear to match this canonical sequence exactly.
Pfam PF09817: RZZ complex, subunit zwilch (family)
The protein Zwilch is an essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. It is required for the assembly of the dynein-dynactin, Mad2 complexes and spindly/CG15415 onto kinetochores.
Pfam PF14777: Cilia BBSome complex subunit 10 (family)
The BBSome (so-named after the association with Bardet-Biedl syndrome) is a complex of 8 subunits that lies at the base of the flagellar microtubule structure. The precise function of the all the individual components in cilia formation is unclear, however they function to promote loading of cargo to the ciliary axoneme. BBIP10 localises to the primary cilium, and is present exclusively in ciliated organisms. It is required for cytoplasmic microtubule polymerisation and acetylation, two functions not shared with any other BBSome subunits. BBIP10 physically interacts with HDAC6. BBSome-bound BBIP10 may therefore function to couple acetylation of axonemal microtubules and ciliary membrane growth. The primary cilium, a slim microtubule-based organelle that projects from the surface of vertebrate cells has crucial roles in vertebrate development and human genetic diseases. Cilia are required for the response to developmental signals, and evidence is accumulating that the primary cilium is specialised for Hedgehog (Hh) signal transduction. Formation of cilia, in turn, is regulated by other signalling pathways, possibly including the planar cell polarity pathway. The connections between cilia and developmental signalling have begun to clarify the basis of human diseases associated with ciliary dysfunction.
Pfam PF07061: Swi5 (family)
Swi5 is involved in meiotic DNA repair synthesis and meiotic joint molecule formation.  It is known to interact with Swi2, Rhp51 and Swi6.
Pfam PF21816: Zap1, C2H2 zinc finger 1 (domain)
Zap1 transcription factor controls the expression of genes that regulate zinc homeostasis in Saccharomyces cerevisiae. Zap1 contains seven classical C2H2 zinc fingers. This domain corresponds to zinc finger 1 (zf1) which together with zinc finger 2 (zf2) has been shown to be a responsive transcriptional activator. Both zinc fingers interact cooperatively to stabilize the Zn-binding.