SII-SWORD/CoKE huggingface dataset:
Pfam PF16418: CCR4-NOT transcription complex subunit 1 HEAT repeat (repeat)
This domain is a HEAT repeat found in CCR4-NOT transcription complex subunit 1.
Wikipedia: CCR4-NOT transcription complex subunit 1 is a protein that in humans is encoded by the CNOT1 gene.
Pfam PF24917: Bridge-like lipid transfer protein family member 3A/B (repeat)
This entry represents the human Bridge-like lipid transfer protein family member 3A and 3B and related proteins. These proteins are tube-forming lipid transport protein which mediate the transfer of lipids between membranes at organelle contact sites. They are required for retrograde traffic of vesicle clusters in the early endocytic pathway to the Golgi complex.
Pfam PF23717: Family of unknown function (DUF7159) (domain)
This domain is found at the C-terminal end of a group of uncharacterised sequences from actinobacteria. It is normally found associated with [pfam:PF23715].
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF16724: T4-like virus Myoviridae tail sheath stabiliser (domain)
T4-gp15_tss is the tail-sheath-stabiliser or tail-terminator protein of T4-like myoviridae phage. It forms a hexamer. It simultaneously forms the binding site for attachment of the capsid to the tail as gp15 binds to gp14 and gp13, the neck proteins, and completes the tail as it binds to the top of the tail via hexamer gp3 and the C-terminal domain of gp18 located in the last ring of the contractile tail sheath.
Pfam PF00988: Carbamoyl-phosphate synthase small chain, CPSase domain (domain)
The carbamoyl-phosphate synthase domain is in the amino terminus of  protein. Carbamoyl-phosphate synthase catalyses the ATP-dependent synthesis of carbamyl-phosphate from  glutamine or ammonia and bicarbonate.  This  important enzyme initiates both the urea cycle and the biosynthesis  of arginine and/or pyrimidines. The carbamoyl-phosphate synthase (CPS) enzyme in prokaryotes is a  heterodimer of a small and large chain. The small chain promotes the hydrolysis of glutamine to ammonia, which is used by the large chain to synthesise carbamoyl phosphate. See [pfam:PF00289]. The small chain has a GATase domain in the carboxyl terminus. See [pfam:PF00117].
Wikipedia: Carbamoyl phosphate synthetase catalyzes the ATP-dependent synthesis
of carbamoyl phosphate from glutamine or ammonia and bicarbonate. This ATP-grasp enzyme catalyzes the reaction of ATP and bicarbonate to produce carboxy phosphate and ADP. Carboxy phosphate reacts with ammonia to give carbamic acid. In turn, carbamic acid reacts with a second ATP to give carbamoyl phosphate plus ADP.
Pfam PF02478: Pneumovirus phosphoprotein (family)
This family represents the phosphoprotein of Paramyxoviridae,  a putative RNA polymerase alpha subunit that may function in template binding.
Pfam PF17420: Superinfection exclusion gene product 17 (family)
Bacteriophages infect host cells by injecting their genome through the cell wall. To this end, tailed bacteriophages have evolved complex tail machines that extend from a unique capsid vertex, providing both an attachment point to the host surface, and a channel for genome-ejection through the cell envelope. Family members of this domain are putative gp17 proteins involved in genome delivery tail machine in Entereobacteria phage p22 and Salmonella phage ViI.  Gp17 found in other bacteriophages such as SPP1 (siphophage SPP1, a lytic Bacillus subtilis phage) has been identified as a tail completion protein adopting an alpha/beta fold, and found to be located at the interface between the head-to-tail connector and the tail of bacteriophage SPP1.
Pfam PF11332: Protein of unknown function (DUF3134) (family)
This family of proteins with unknown function appears to be restricted to Cyanobacteria.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF02230: Phospholipase/Carboxylesterase (domain)
This family consists of both phospholipases and carboxylesterases with broad substrate specificity, and is structurally related to  alpha/beta hydrolases [pfam:PF00561].
Wikipedia: The alpha/beta hydrolase superfamily is a superfamily of hydrolytic enzymes of widely differing phylogenetic origin and catalytic function that share a common fold. The core of each enzyme is an alpha/beta-sheet, containing 8 beta strands connected by 6 alpha helices. The enzymes are believed to have diverged from a common ancestor, retaining little obvious sequence similarity, but preserving the arrangement of the catalytic residues. All have a catalytic triad, the elements of which are borne on loops, which are the best-conserved structural features of the fold.
Pfam PF22964: Protein zer-1 homolog-like, C-terminal domain (repeat)
This entry represents the C-terminal domain of human Protein zer-1 homolog (ZER1) and similar eukaryotic proteins. ZER1 serves as substrate adapter subunit in the E3 ubiquitin ligase complex ZYG11B-CUL2-Elongin BC. This protein functions to target substrates bearing N-terminal degrons for proteasomal degradation with the first four residues of substrates being the key recognition elements. This domain consists of armadillo repeats.
Pfam PF17374: Family of unknown function (DUF5396) (family)
This is a family of unknown function found in Mycoplasma.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF20880: Phage G1 gp67, N-terminal domain (domain)
gp67 from Staphylococcus virus G1 binds to the sigma(A)-subunit of the RNA polymerase (RNAP) of its host to block cell growth by inhibiting transcription. This protein is organized in two domains, an N-terminal beta-sheet-rich domain (this entry) and a C-terminal alpha-helical domain, which are connected by a linker-alpha-helix on the surface of gp67 opposite the interaction surface.
Pfam PF06147: Protein of unknown function (DUF968) (family)
Family of uncharacterised prophage proteins found in Gammaproteobacteria. These may be HNH-nucleases, as there are several conserved cysteines and histidines.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF20336: Family of unknown function (DUF6631) (family)
This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and viruses. Proteins in this family are typically between 132 and 168 amino acids in length.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF03447: Homoserine dehydrogenase, NAD binding domain (domain)
This domain adopts a Rossmann NAD binding fold.  The C-terminal domain of homoserine dehydrogenase contributes a single helix to this structural domain, which is not included in the Pfam model.
Pfam PF01275: Myelin proteolipid protein (PLP or lipophilin) (family)
The myelin sheath is a multi-layered membrane, unique to the nervous system, that functions as an insulator to greatly increase the velocity of axonal impulse conduction . Myelin proteolipid protein (PLP or lipophilin)  is the major myelin protein from the central nervous system (CNS). It probably plays an important role in the formation or maintenance of the multilamellar structure of myelin. In man point mutations in PLP are the cause of Pelizaeus-Merzbacher disease (PMD), a neurologic disorder of myelin metabolism. In animals dismyelinating diseases such as mouse 'jimpy' (jp), rat md, or dog 'shaking pup' are also caused by mutations in PLP.

PLP is a highly conserved  hydrophobic protein of 276 to 280 amino acids which seems to contain four transmembrane segments, two disulphide bonds and which covalently binds lipids (at least six palmitate groups in mammals) .

PLP is highly related to M6, a neuronal membran glycoprotein .
Wikipedia: Myelin proteolipid protein is the major myelin protein from the central nervous system (CNS). It plays an important role in the formation or maintenance of the multilamellar structure of myelin. The myelin sheath is a multi-layered membrane, unique to the nervous system, that functions as an insulator to greatly increase the efficiency of axonal impulse conduction.
Pfam PF13931: Kinesin-associated microtubule-binding (family)
This domain binds to micotubules.
Pfam PF24530: Domain of unknown function (DUF7597) (domain)
This domain is found in uncharacterised plant proteins.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF22903: Diels-Alderase, C-terminal domain (domain)
This domain is found C-terminal in a number of fungal Diels-Alderases. Amongst these are Diels-Alderase mycB, Diels-Alderase mpsD, Diels- Alderase cghA and others. These enzymes consist of two similar beta-barrel domains with arrangement similar to AttH. Both domains share some similarity to lipocalins.
Pfam PF14498: Glycosyl hydrolase family 65, N-terminal domain (domain)
This domain represents a domain found to the N-terminus of the glycosyl hydrolase 65 family catalytic domain.
Wikipedia: In molecular biology, glycoside hydrolase family 65 is a family of glycoside hydrolases.
Pfam PF15640: Metallopeptidase toxin 4 (family)
A zincin-like metallopeptidase domain found in bacterial polymorphic toxin systems.
Pfam PF14121: Putative porin (family)
This family of membrane bet-barrel proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 655 and 722 amino acids in length. [swissprot:Q2S343] is identified by Gene3D as a membrane bound beta-barrel.  These sequences are putative porins.
Pfam PF18379: FERM F1 ubiquitin-like domain (domain)
This is an F1 lobe domain consisting of a ubiquitin like fold found in FERM region of Jak-family tyrosine kinases. Multidomain JAK molecules interact with receptors through their FERM and SH2-like domains, triggering a series of phosphorylation events, resulting in the activation of their kinase domains. Overall, the FERM region maintains the typical three-lobed architecture, with an F1 lobe consisting of a ubiquitin-like fold, an F2 lobe consisting of an acyl-CoA binding protein fold, and an F3 lobe consisting of a pleckstrin-homology (PH) fold.
Wikipedia: In molecular biology, the FERM domain is a widespread protein module involved in localising proteins to the plasma membrane. FERM domains are found in a number of cytoskeletal-associated proteins that associate with various proteins at the interface between the plasma membrane and the cytoskeleton. The FERM domain is located at the N terminus in the majority of proteins in which it is found.
Pfam PF24682: RRP5 OB-fold domain (domain)
This domain is found in the rRNA biogenesis protein RRP5 from Arabidopsis thaliana and related plant proteins. RRP5 is involved in the biogenesis of ribosomal RNA (rRNA). It is required for the formation of 5.8S rRNA and for normal development of female gametophytes. This domain has a detectable similarity to OB fold domains, in particular to OB domain of 30S ribosomal protein S1 and it is predicted to adopt similar structure.
Pfam PF04337: Protein of unknown function, DUF480 (family)
This family consists of several proteins of uncharacterised function.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF22807: TrAA12-like (repeat)
This entry represents homologues of the AA12 enzyme from Trichoderma reesei. This enzyme adopts six-bladed beta-propeller structure. AA12 shows similarities to the global active-site architecture of bacterial glucose dehydrogenases, suggesting their common evolutionary origin.
Pfam PF02787: Carbamoyl-phosphate synthetase large chain, oligomerisation domain (domain)
Carbamoyl-phosphate synthase catalyses the ATP-dependent synthesis of carbamyl-phosphate from glutamine or ammonia and bicarbonate. The carbamoyl-phosphate synthase (CPS) enzyme in prokaryotes is a  heterodimer of a small and large chain.
Wikipedia: Carbamoyl phosphate synthetase catalyzes the ATP-dependent synthesis
of carbamoyl phosphate from glutamine or ammonia and bicarbonate. This ATP-grasp enzyme catalyzes the reaction of ATP and bicarbonate to produce carboxy phosphate and ADP. Carboxy phosphate reacts with ammonia to give carbamic acid. In turn, carbamic acid reacts with a second ATP to give carbamoyl phosphate plus ADP.
Pfam PF15667: Protein of unknown function with motif GDWWSH (family)
This family of proteins is found in eukaryotes. Proteins in this family are typically between 135 and 289 amino acids in length. There are three conserved sequence motifs: GDWWSH, RSDF and KRHG.
Pfam PF14564: Membrane binding (domain)
This family includes the C-terminal domain of Dictyostelium discoideum Calcium-dependent cell adhesion molecule 1 ([swissprot:P54657]), which has an immunoglobulin-like fold. It tethers the protein to the cell membrane.
Pfam PF23070: Domain of unknown function (DUF7043) (domain)
This domain is found in a group of uncharacterised metazoan proteins. It is predicted to adopt a globular structure with lipocalin fold. It also contains several highly conserved cysteine residues that are likely involved in the formation of intra-domain disulfide bridges.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF16292: Domain of unknown function (DUF4938) (family)
A small family consists of several uncharacterized proteins around 300 residues in length and is mainly found in various Chloroflexus, Comamonas, Delfitia, Rubrivivax and Roseiflexus species. Several members are annotated as cyanophycin synthetases, but the function of this family is unknown.
Pfam PF07999: Retrotransposon hot spot protein, P-loop domain (domain)
Members of this entry are retrotransposon hot spot proteins (RHSPs). They are associated with polymorphic subtelomeric regions in Trypanosoma. These proteins contain a P-loop (ATP/GTP-binding) motif, represented in this entry, at the C-terminal of the conserved box 1. This domain also includes the retrotransposon insertion site.
Pfam PF20370: Family of unknown function (DUF6665) (family)
This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 110 amino acids in length.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF09214: Bacteriophage Prd1, adsorption protein P2 (family)
Members of this family form a set of bacteriophage adsorption proteins, composed mainly of beta-strands whose complicated topology forms an elongated seahorse-shaped molecule with a distinct head, containing a pseudo-beta propeller structure with approximate 6-fold symmetry, and tail. They are required for the attachment of the phage to the host conjugative DNA transfer complex. This is a poorly understood large transmembrane complex of unknown architecture, with at least 11 different proteins.
Pfam PF06377: Adipokinetic hormone (family)
This family consists of several insect adipokinetic hormone as well as the related crustacean red pigment concentrating hormone. Flight activity of insects comprises one of the most intense biochemical processes known in nature, and therefore provides an attractive model system to study the hormonal regulation of metabolism during physical exercise. In long-distance flying insects, such as the migratory locust, both carbohydrate and lipid reserves are utilised as fuels for sustained flight activity. The mobilization of these energy stores in Locusta migratoria is mediated by three structurally related adipokinetic hormones (AKHs), which are all capable of stimulating the release of both carbohydrates and lipids from the fat body.
Pfam PF14670: Coagulation Factor Xa inhibitory site (domain)
This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.
Pfam PF24093: Domain of unknown function (DUF7377) (domain)
This domain is found in uncharacterised plant proteins. It is predicted to adopt an alpha/beta structure with a central four-stranded antiparallel beta-sheet and alpha helices packed on it. It has weak sequence and structural similarity to NIL domains. It is usually found N-terminal to protein kinase domains.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF08479: POTRA domain, ShlB-type (domain)
The POTRA domain (for polypeptide-transport-associated domain) is found towards the N-terminus of ShlB family proteins ([pfam:PF03865]). ShlB is important in the secretion and activation of the haemolysin ShlA. It has been postulated that the POTRA domain has a chaperone-like function over ShlA; it may fold back into the C-terminal beta-barrel channel.
Pfam PF03245: Bacteriophage Rz lysis protein (domain)
This protein is involved in host lysis. This family is not considered to be a peptidase according to the MEROPs database. This family Rz and the Rz1 protein ([pfam:PF06085]) represent a unique example of two genes located in different reading frames in the same nucleotide sequence, which encode different proteins that are both required in the same physiological pathway.
Pfam PF08194: DIM protein (family)
Drosophila immune-induced molecules (DIMs) are short proteins induced during the immune response of Drosophila. This family includes DIMs 1 to 4 that have masses below 5 kDa.
Wikipedia: Drosocin is a 19-residue long antimicrobial peptide (AMP) of flies first isolated in the fruit fly Drosophila melanogaster, and later shown to be conserved throughout the genus Drosophila. Drosocin is regulated by the NF-κB Imd signalling pathway in the fly.
Pfam PF13073: Protein of unknown function (DUF3937) (family)
This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 80 amino acids in length.
Pfam PF18180: SLOG cluster3 family (family)
Family in the SLOG superfamily, observed to associate with a predicted effector protein containing one enzymatically active and inactive copy of the TIR domain.
Pfam PF14876: Respiratory growth transcriptional regulator (family)
This is a family of transcriptional regulators that determine the transition from fermentative activity to growth on glycerol.
Pfam PF04883: Bacteriophage HK97-gp10, putative tail-component (family)
This family of proteins is found in the caudovirales.  It may be a tail component.
Pfam PF05582: YabG peptidase U57 (family)
YabG is a protease involved in the proteolysis and maturation of SpoIVA and YrbA proteins, conserved with the cortex and/or coat assembly by Bacillus subtilis.
Pfam PF07190: Tumour necrosis factor receptor, SECRET domain (domain)
This domain, named as the SECRET domain, is found at the C-terminal end of Tumour necrosis factor receptor (CrmD) from the orthopoxvirus Ectromelia virus. This domain binds a subset of human and mouse CC, CXC and C chemokines. It is thought to be responsible for the anti-chemokine activity of CrmD. The SECRET domain monomer adopts a beta-sandwich fold, consisting of two parallel beta-sheets with five and six anti-parallel strands, and the connecting loops. This domain is also found in other uncharacterised sequences from poxvirus, including Protein OPG192 and Protein C8 from Vaccinia virus.
Pfam PF08105: Metchnikowin family (family)
This family consists of the metchnikowin family of antimicrobial peptides from Drosophila.                    metchnikowin is a proline-rich peptide whose expression is immune-inducible. Induction of the metchnikowin gene expression can be mediated either by the TOLL pathway or by the imd gene product. The metchnikowin peptide is unique among the Drosophila antimicrobial peptides in that it is active against both bacteria and fungi.
Pfam PF04228: Putative neutral zinc metallopeptidase (family)
Members of this family have a predicted zinc binding motif characteristic of neutral zinc metallopeptidases (Prosite:PDOC00129).
Pfam PF19366: Domain of unknown function (DUF5942) (domain)
This presumed integral membrane domain is functionally uncharacterised. This domain family is found mainly in cyanobacteria, and is approximately 190 amino acids in length. The family is found to the C-terminus of [pfam:PF00082].
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.