SII-SWORD/CoKE huggingface dataset:
Pfam PF20599: Family of unknown function (DUF6796) (family)
This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and fungi. Proteins in this family are typically between 220 and 250 amino acids in length.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF20099: Family of unknown function (DUF6489) (family)
This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 90 amino acids in length.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF15134: Centrosomal protein 15-like (family)
This family of animal proteins includes human Centrosomal protein 15 (CEP15), which may play a role in ciliary assembly.
Pfam PF06232: Embryo-specific protein 3, (ATS3) (domain)
This is a family of plant seed-specific proteins identified in Arabidopsis thaliana (Mouse-ear cress). ATS3 (Arabidopsis thaliana  seed gene 3) is expressed in a pattern similar to the Arabidopsis  seed storage protein genes.
Pfam PF19190: Viral BACON domain (domain)
This family represents a distinct class of BACON domains found in crAss-like phages, the most common viral family in the human gut, in which they are found in tail fiber genes. This suggests they may play a role in phage-host interactions.
Pfam PF13545: Crp-like helix-turn-helix domain (domain)
This family represents a crp-like helix-turn-helix domain that is likely to bind DNA.
Pfam PF23183: NPAS4 bHLH domain (domain)
This bHLH domain is found in the family of Neuronal PAS domain-containing protein 4 (NPAS4). NPAS4 is a transcription factor expressed in neurons of the brain that regulates the excitatory-inhibitory balance within neural circuits and is required for contextual memory in the hippocampus. It binds to DNA but efficient DNA binding requires dimerization with another bHLH protein, such as ARNT, ARNT2 or BMAL1.
Pfam PF04598: Gasdermin pore forming domain (domain)
The precise function of this protein is unknown. A deletion/insertion mutation is associated with an autosomal dominant non-syndromic hearing impairment form. In addition, this protein has also been found to contribute to acquired etoposide resistance in melanoma cells. This family also includes the gasdermin protein
Pfam PF08788: NHR2 domain like (domain)
The NHR2 (Nervy homology 2) domain is found in the ETO protein where it mediates oligomerisation and protein-protein interactions.  It forms an alpha-helical tetramer.
Pfam PF25017: C2HC zinc finger (domain)
This domain is found C-terminal in uncharacterised plant proteins. It has three invariant cysteine residues and a histidine that are likely involved in metal coordination. It is probably a variant of the classical C2H2 zinc fingers and is predicted to adopt similar structure.
Pfam PF20345: Family of unknown function (DUF6640) (family)
This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and eukaryotes. Proteins in this family are typically between 133 and 156 amino acids in length.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF09021: HutP (domain)
The HutP protein family regulates the expression of Bacillus 'hut' structural genes by an anti-termination complex, which recognises three UAG triplet units, separated by four non-conserved nucleotides on the RNA terminator region. L-histidine and Mg2+ ions are also required. These proteins exhibit the structural elements of alpha/beta proteins, arranged in the order: alpha-alpha-beta-alpha-alpha-beta-beta-beta in the primary structure, and the four antiparallel beta-strands form a beta-sheet in the order beta1-beta2-beta3-beta4, with two alpha-helices each on the front (alpha1 and alpha2) and at the back (alpha3 and alpha4) of the beta-sheet.
Pfam PF12313: NPR1/NIM1 like defence protein C terminal (family)
This family of proteins is found in eukaryotes. Proteins in this family are typically between 251 and 588 amino acids in length. The family is found in association with [pfam:PF00023], [pfam:PF00651]. There are two conserved sequence motifs: LENRV and DLN. NPR1 (NIM1) is a defence protein in many plant species.
Pfam PF17533: Family of unknown function (DUF5452) (family)
This is a family of unknown function found in Mycoplasmataceae.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF03633: Glycosyl hydrolase family 65, C-terminal domain (domain)
This family of glycosyl hydrolases contains vacuolar acid trehalase and maltose phosphorylase.Maltose phosphorylase (MP) is a dimeric enzyme that catalyses the conversion of maltose and inorganic phosphate into beta-D-glucose-1-phosphate and glucose.  The C-terminal domain forms a two layered jelly roll motif.  This domain is situated at the base of the catalytic domain, however its function remains unknown.
Wikipedia: In molecular biology, glycoside hydrolase family 65 is a family of glycoside hydrolases.
Pfam PF08367: Peptidase M16C associated (family)
This domain appears in eukaryotes as well as bacteria and tends to be found near the C-terminus of the metalloprotease M16C ([pfam:PF05193]).
Pfam PF08246: Cathepsin propeptide inhibitor domain (I29) (domain)
This domain is found at the N-terminus of some C1 peptidases such as Cathepsin L where it acts as a propeptide.  There are also a number of proteins that are composed solely of multiple copies of this domain such as the peptidase inhibitor salarin [swissprot:Q70SU8]. This family is classified as I29 by MEROPS.
Wikipedia: In biology and biochemistry, protease inhibitors, or antiproteases, are molecules that inhibit the function of proteases. Many naturally occurring protease inhibitors are proteins.
Pfam PF20427: Nuclear speckle splicing regulatory protein 1, RS-like domain (domain)
This domain found at the C-terminal of Nuclear speckle splicing regulatory protein 1 (NRP1, also known as Nuclear speckle-related protein 70 and Coiled-coil domain-containing protein 55). This is the RS-like domain, that resembles the arginine/serine-rich (RS) domain in other SR proteins, interacts with two SR proteins and with target mRNA, being essential for NRP1 activity. NRP1 is a RNA-binding protein that mediates pre-mRNA alternative splicing regulation.
Pfam PF24849: Domain of unknown function (DUF7724) (domain)
This entry represents a family of bacterial proteins composed of an all beta strand domain composed of 7 beta strands. Structure prediction suggests that these proteins will form a complex with proteins from [pfam:PF24848].
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF23084: PARP14, first type I KH domain (domain)
This domain is found in human Protein mono-ADP- ribosyltransferase PARP14 and related proteins. PARP14 is a large multidomain protein which in the N-terminal half contains a series of consecutive RRM and KH domains that are known to be nucleic acid-binding. PARP14 is involved in multiple signaling pathways linked to cancer, inflammation, and infection. PARP14 is an ADP-ribosyltransferase that mediates mono-ADP-ribosylation of glutamate residues on target proteins. In contrast to PARP1 and PARP2, it is not able to mediate poly-ADP-ribosylation. The domain represented by this entry is a KH domain found first in the human PARP14.
Pfam PF02358: Trehalose-phosphatase (family)
This family consist of trehalose-phosphatases [ec:3.1.3.12] these enzyme catalyse the de-phosphorylation of trehalose-6-phosphate to trehalose and orthophosphate.  The aligned region is present in  trehalose-phosphatases and comprises the entire length of the protein it is also found in the C-terminus of trehalose-6-phosphate synthase  [ec:2.4.1.15] adjacent to the trehalose-6-phosphate synthase domain - [pfam:PF00982].  It would appear that the two equivalent genes in the  E. coli otsBA operon otsA the trehalose-6-phosphate synthase and otsB trehalose-phosphatase (this family) have undergone gene fusion in most eukaryotes e.g. [swissprot:P31688] and [swissprot:P93653]. Trehalose is a common disaccharide of bacteria, fungi and invertebrates that appears to play a major role in desiccation tolerance.
Pfam PF13975: gag-polyprotein putative aspartyl protease (domain)
This family of putative aspartyl proteases is found pre-dominantly in retroviral proteins.
Pfam PF02411: MerT mercuric transport protein (family)
MerT is an mercuric transport integral membrane protein and  is responsible for transport of the Hg2+ iron from periplasmic MerP (also part of the transport system) to mercuric reductase (MerE).
Pfam PF10858: Protein of unknown function (DUF2659) (repeat)
This bacterial family of proteins has no known function.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF05612: Leg1 (family)
Protein liver-enriched gene 1 (Leg1) has been suggested to function as a novel secreted regulator for the liver development.
Pfam PF03629: Carbohydrate esterase, sialic acid-specific acetylesterase (domain)
The catalytic triad of this esterase enzyme comprises residues Ser127, His403 and Asp391 in UniProtKB:P70665.
Pfam PF01043: SecA preprotein cross-linking domain (domain)
The SecA ATPase is involved in the insertion and retraction of preproteins through the plasma membrane.  This domain has been found to cross-link to preproteins, thought to  indicate a role in  preprotein binding.  The pre-protein cross-linking domain is comprised of two sub domains that are inserted within the ATPase domain.
Pfam PF07500: Transcription factor S-II (TFIIS), central domain (domain)
Transcription elongation by RNA polymerase II is regulated by the general elongation factor TFIIS. This factor stimulates  RNA polymerase II to transcribe through regions of DNA that  promote the formation of stalled ternary complexes. TFIIS is composed of three structural domains, termed I, II, and III.  The two C-terminal  domains (II and III), this domain and [pfam:PF01096] are required for transcription activity.
Pfam PF07976: Phenol hydroxylase, C-terminal dimerisation domain (domain)
Phenol hydroxylase acts a homodimer, to hydroxylates phenol to catechol or similar product. The enzyme is comprised of three domains. The first two domains from the active site. The third domain, this domain, is involved in forming the dimerisation interface. The domain adopts a thioredoxin-like fold.
Pfam PF17724: Family of unknown function (DUF5568) (family)
This is a family of unknown function found in chordata.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF10678: Protein of unknown function (DUF2492) (family)
This is a bacterial family of uncharacterised proteins.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF13265: Protein of unknown function (DUF4056) (family)
This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 355 and 380 amino acids in length.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF18621: Rv3651-like, middle domain (domain)
This domain is found in Rv3651 from Mycobacterium tuberculosis ([swissprot:I6YCP0]) and similar proteins from Actinobacteria. Rv3651 adopts a three-domain configuration. This entry represents the middle domain, a PAS domain that shows a central antiparallel beta-sheet of five beta-strands.
Pfam PF11075: Protein of unknown function VcgC/VcgE (DUF2780) (family)
This is a bacterial family of uncharacterised proteins.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF04520: Senescence regulator (family)
This protein regulates the expression of proteins associated with leaf senescence in plants.
Pfam PF19811: Family of unknown function (DUF6294) (family)
This BGC (BGC0000081) is described by MIBiG as an example of the following biosynthetic class, polyketide, in particular the kedarcidin biosynthetic gene cluster from Streptoalloteichus sp. ATCC 53650CC. This family appears to be predominantly found in bacteria.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF09496: Cenp-O kinetochore centromere component (family)
This eukaryotic protein is a component of the inner kinetochore subcomplex of the centromere.  It has been shown to be involved in chromosome segregation via regulation of the spindle in both yeast and human.
Pfam PF07288: RNA polymerase epsilon subunit (domain)
RNA polymerase in bacteria is a multisubunit protein complex that is essential for gene expression. This entry represents the epsilon subunit encoded by the rpoY gene. The structure of epsilon shows simple beta sheet with an alpha helix running diagonally along the back of the structure forming a beta-beta-alpha-beta fold.
Pfam PF14200: Ricin-type beta-trefoil lectin domain-like (domain)
Ricin is a legume lectin from the seeds of the castor bean plant, Ricinus communis. The seeds are poisonous to people, animals and insects and just one milligram of ricin can kill an adult.

Primary structure analysis has shown the presence of a similar domain in many carbohydrate-recognition proteins like plant and bacterial AB-toxins, glycosidases or proteases . This domain, known as the ricin B lectin domain, can be present in one or more copies and has been shown in some instance to bind simple sugars, such as galactose or lactose.

The ricin B lectin domain is composed of three homologous subdomains of 40 amino acids (alpha, beta and gamma) and a linker peptide of around 15 residues (lambda). It has been proposed that the ricin B lectin domain arose by gene triplication from a primitive 40 residue galactoside-binding peptide . The most characteristic, though not completely conserved, sequence feature is the presence of a Q-W pattern. Consequently, the ricin B lectin domain as also been refered as the (QxW)3 domain and the three homologous regions as the QxW repeats . A disulphide bond is also conserved in some of the QxW repeats .

The 3D structure of the ricin B chain has shown that the three QxW repeats pack around a pseudo threefold axis that is stabilised by the lambda linker . The ricin B lectin domain has no major segments of a helix or Î²-sheet but each of the QxW repeats contains an Ï-loop . An idealized Ï-loop is a compact, contiguous segment of polypeptide that traces a 'loop-shaped' path in three-dimensional space; the main chain resembles a Greek omega.
Wikipedia: Ricin ( RY-sin) is a lectin (a carbohydrate-binding protein) and a highly potent toxin produced in the seeds of the castor oil plant, Ricinus communis. The median lethal dose (LD50) of ricin for mice is around 22 micrograms per kilogram of body weight via intraperitoneal injection. Oral exposure to ricin is far less toxic. An estimated lethal oral dose in humans is approximately one milligram per kilogram of body weight.
Pfam PF07466: Protein of unknown function (DUF1517) (family)
This family consists of several hypothetical glycine rich plant and bacterial proteins of around 300 residues in length. The function of this family is unknown.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF19445: C-terminal region of eIF3h (family)
This entry represents a C-terminal helical region present in eukaryotic initiation factor 3 chain H. This protein is part of the eIF3 complex that is involved in eukaryotic translation initiation. eIF3 is a large and structurally complex molecular assembly that, in the majority of eukaryotes, consists of 11-13 subunits (eIF3a-IF3m) with a molecular weight of 600-800 kDa.
Pfam PF17119: Mitochondrial protein up-regulated during meiosis (family)
This is a family of fungal mitochondrial proteins of unknown function.
Pfam PF07481: Domain of Unknown Function (DUF1521) (family)
This family of unknown function is found in a limited  set of Bradyrhizobium proteins. There appears to be a periodic -DG- motif in it.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF18903: Domain of unknown function (DUF5659) (domain)
This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and archaea. Proteins in this family are typically between 78 and 90 amino acids in length.
Pfam PF12494: Protein of unknown function (DUF3695) (family)
This family of proteins is found in eukaryotes. Proteins in this family are typically between 157 and 192 amino acids in length. There is a single completely conserved residue D that may be functionally important. The family includes Protein CFAP276 and homologues. CFAP276 has been suggested to be involved in intracellular Ca2 homeostasis.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF22953: Polyketide synthase extender module SpnB, Rossmann fold domain (domain)
This entry represents a domain found in a group of proteins mainly found in actinomycetes, including the polyketide synthase extender module SpnB from Saccharopolyspora spinosa. This domain shows a classical Rossmann fold.
Pfam PF24793: Glucosamine inositolphosphorylceramide transferase 1, N-terminal (repeat)
This is the N-terminal domain of Glucosamine inositolphosphorylceramide transferase 1 from Arabidopsis thaliana (GINT1), a member of the Glycosyltransferase Family 64 that is involved in glycosylinositolphosphorylceramide and sphingolipid glycosylation. This domain is predicted to adopt a five-bladed beta-propeller fold.
Pfam PF22109: Transcription factor IIB, zinc ribbon, Trypanosome (domain)
This entry represents the zinc ribbon domain found at the N-terminal of transcription factor IIB from Trypanosomes. tTFIIB is essential for spliced leader (SL) RNA gene transcription and cell viability, but has a highly divergent primary sequence in comparison to TFIIB in other eukaryotes.
Pfam PF02748: Aspartate carbamoyltransferase regulatory chain, metal binding domain (domain)
The regulatory chain is involved in allosteric regulation of aspartate carbamoyltransferase. The C-terminal metal binding domain has a rubredoxin-like fold and  provides the interface with the catalytic chain.
Pfam PF20214: Family of unknown function (DUF6574) (family)
This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria, mainly Firmicutes. Proteins in this family are typically between 116 and 320 amino acids in length. Many members are thought to contain a zinc ribbon domain located at the N terminus.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.