SII-SWORD/CoKE huggingface dataset:
Pfam PF07363: Protein of unknown function (DUF1484) (family)
This family consists of several hypothetical bacterial proteins of around 110 residues in length. Members of this family appear to be found exclusively in Ralstonia solanacearum. The function of this family is unknown.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF19283: Acylamino-acid-releasing enzyme, N-terminal domain (family)
This entry represents the N-terminal region from the Acylamino-acid-releasing enzyme ([ec:3.4.19.1]). The protein is involved in removing the N-acetyl or N-formyl amino acid from the N-terminus of a polypeptide. This domain does not represent the catalytic domain which is found at the C-terminus of these proteins.
Pfam PF20078: Domain of unknown function (DUF6473) (domain)
This presumed domain is functionally uncharacterised. This domain family is found in bacteria, and is typically between 141 and 178 amino acids in length.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF16278: C2HE / C2H2 / C2HC zinc-binding finger (domain)
zf-C2HE is an unusual zinc-binding domain found in fungi, plants and metazoa. It is often found at the C-terminus of HIT-domain-containing proteins, [pfam:PF01230]. In fungi the fourth ligand is a Glu, in plants it is Cys and in metazoans it is usually a His.  The fourth ligand is often mutated in neurogenerative disease-states.
Pfam PF09909: Uncharacterized protein conserved in bacteria (DUF2138) (family)
This domain, found in various hypothetical prokaryotic proteins, has no known function.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF13452: FAS1-like, dehydratase domain region (domain)
This is a region of the dehydratase domain found in Fatty acid synthase subunit beta from Saccharomyces cerevisiae (FAS1,) and similar sequences mainly found in eukaryotes and bacteria. FAS1 catalyses the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. This entry is often found associated with [pfam:PF01575].
Pfam PF14237: GYF domain 2 (domain)
This domain is found in bacteria, archaea and eukaryotes, and is approximately 50 amino acids in length. It contains an evolutionary conserved signature W-X-Y-X6-11-GPF-X4-M-X2-W-X3-GYF, the site of interaction with proline-rich peptides. Family members include RME-8 (Required for receptor-mediated endocytosis 8), a DNAJC13 protein. RME-8 was first identified as a protein that is required for endocytosis in Caenorhabditis elegans. It coordinates the activity of the WASH complex with the function of the retromer SNX dimer to control endosomal tubulation. Family members found in Arabidopsis include Arabidopsis trithorax-related3 (Atxr3), also known as set domain group 2 (Sdg2). It is the major enzyme responsible for H3K4me3 in Arabidopsis and SDG2-dependent H3K4m3 is critical for regulating gene expression and plant development. Another family member found in Arabidopsis is Tic56. It is an essential subunit of a 1-MDa protein complex at the inner chloroplast envelope membrane. Furthermore, Tic56 is important for rRNA processing and chloroplast ribosome assembly.
Pfam PF07256: Protein of unknown function (DUF1435) (family)
This family consists of several hypothetical Enterobacterial proteins of around 80 residues in length. The function of this family is unknown.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF22125: Hypotheical protein Lreu_0056 (domain)
This entry represents a domain found in a family of Lactobacillus proteins whose structure has been characterised (PDB:2mqd).
Pfam PF03255: Acetyl co-enzyme A carboxylase carboxyltransferase-like (family)
Acetyl co-enzyme A carboxylase carboxyltransferase is composed of an alpha and beta subunit. This protein family includes the alpha subunit and similar sequences.
Pfam PF18189: TbRIF5 SNase domain 2 (domain)
Staphylococcus nuclease (SNase) domain family found in the Trypanosoma brucei TbRIF5 protein, which could contribute to the processing of dsRNA targets.
Pfam PF09661: Protein of unknown function (DUF2398) (family)
Proteins in this entry are encoded within a conserved gene four-gene neighbourhood found sporadically in a phylogenetically broad range of bacteria including: Nocardia farcinica, Symbiobacterium thermophilum, and Streptomyces avermitilis (Actinobacteria), Geobacillus kaustophilus (Firmicutes), Azoarcus sp. EbN1 and Ralstonia solanacearum (Betaproteobacteria).
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF17609: Family of unknown function (family)
This is a family of unknown function found in beta-herpesvirus. Family members such as UL124 is a predicted membrane glycoprotein with one predicted trans-membrane region.
Pfam PF21658: Lettuce necrotic yellow virus phosphoprotein C-terminal domain (domain)
This entry represents the C-terminal domain of lettuce necrotic yellows virus phosphoprotein (LNYV-PP), which adopts a lollipop-shaped structure comprising five helices.
Pfam PF08138: Sex peptide (SP) family (family)
This family consists of Sex Peptides (SP) that are found in Drosophila. On mating, Drosophila females decreases her remating rate and increases her egg-laying rate due, in part, to the transfer of SP from the male to the female. SP are found in seminal fluids transferred from the male to the female during mating. The male seminal fluid proteins are referred to as accessory gland proteins (Acps). The SP is one of the most interesting Acps and plays an important role in reproduction.
Pfam PF06376: Arabinogalactan peptide (family)
This entry represents the arabinogalactan peptide  family found in plants.
Pfam PF23374: Archaeal fibronectin-III type-like domain (domain)
This domain is found at the C-terminal end of a group of proteins from halobacteria. It is predicted to show structural similarity to the fibronectin type III domain.
Pfam PF21941: SMEK domain (family)
This entry represents the SMEK domain, which is found at the N-terminal end of a group of bacterial proteins. It is named after four genera in which multiple, diverse members of this group of bacterial proteins are found: Staphylococcus, Mycoplasma, Escherichia, and Klebsiella. The SMEK domain is predicted to adopt an alpha/beta fold that resembles the core of restriction endonuclease enzymes. It contains four scattered invariant residues (Glu, Asp, Gln, and Lys) that may be functionally relevant.
Pfam PF04923: Ninjurin (family)
Ninjurin (nerve injury-induced protein) is involved in nerve regeneration and in the formation and function in some tissues.
Pfam PF22956: VPS15-like, helical domain (repeat)
This entry represents the central domain of VPS15 proteins, which consists of armadillo repeats. VPS15 proteins in animals are known as Phosphoinositide 3-kinase regulatory subunit 4 (Pik3r4), while in S.pombe is known as Ppk19. Vps15 associates and regulates Vps34, also called Class III phosphoinositide 3-kinase (PI3K), which the phosphorylation of D-myo-phosphatidylinositol (PtdIns). Vps34 is the only PI3K present in yeast. It plays an important role in the regulation of protein and vesicular trafficking and sorting, signalling, and phagocytosis. This domain forms 9 helical pairs arranged as a right-handed helical solenoid.
Pfam PF05250: Uncharacterised protein family (UPF0193) (family)
This family of proteins is functionally uncharacterised.
Pfam PF03768: Attacin, N-terminal region (family)
This family includes attacin and sarcotoxin, but not  diptericin (which share similarity to the C-terminal region of attacin). All members of this family are insect antibacterial proteins which are induced by the fat body and subsequently released into secreted into the hemolymph where they act synergistically  to kill the invading microorganism.
Pfam PF23971: Putative phage tail tube protein (family)
This entry shows structural similarity to the Afp1 tail tube protein from the AFP antifeeding prophage of Serratia. This suggests that this family is also likely to form the inner tail tube.
Pfam PF13693: Winged helix-turn-helix DNA-binding (domain)
This entry represent the winged helix-turn-helix DNA-binding found in Ner, a transcriptional regulator from Escherichia phage Mu . This domain can also be found in sugar fermentation stimulation protein B (sfsB), also known as Ner-like protein, from Escherichia coli .
Pfam PF21105: DyP dimeric alpha+beta barrel domain (domain)
This entry represents the N-terminal dimeric alpha beta barrel domain from the dye-decolorizing peroxidase (DyP)-type peroxidase family. This is one of the six families of peroxidases.
Pfam PF06866: Protein of unknown function (DUF1256) (family)
This family consists of several uncharacterised bacterial proteins which seem to be specific to the orders Clostridia and Bacillales. Family members are typically around 180 residues in length. The function of this family is unknown. These proteins are related to peptidase family M63 and so may be peptidases.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF18015: Acetyltransferase (GNAT) domain (domain)
This entry represents a likely acetyltransferase enzyme that is related to [pfam:PF13302].
Wikipedia: An acetyltransferase is any of a class of transferase enzymes that transfers an acetyl group in a reaction called acetylation. In biological organisms, post-translational modification of a protein via acetylation can profoundly transform its functionality by altering various properties like hydrophobicity, solubility, and surface attributes. These alterations have the potential to influence the protein's conformation and its interactions with substrates, cofactors, and other macromolecules.
Pfam PF23281: Dynein axonemal assembly factor 9 N-terminal domain (domain)
This domain is found N-terminal in the human Dynein axonemal assembly factor 9 (DAAF9) and related proteins. It shares similarity with the N-terminal domains of shulin that binds newly synthesized outer dynein arm complexes and the aminopeptidase P domain of Spt16, a core component of the histone chaperone FACT. These domains likely share the same alpha/beta fold with Ribonuclease H-like motif.
Pfam PF03691: Uncharacterised protein family (UPF0167) (family)
The proteins members of this family are about 200 amino acids long and each contain 3 CXXC motifs. They are predicted to contain an N-terminal treble-clef zinc finger with zinc coordinating residues (Cys) conserved in all members of the family. Some members of this family contain a second metal binding site at the C terminus that resembles a variant of the Zinc ribbon finger, Members of this family are mostly found in bacteria, including the protein CbrC (also known as YieJ) from E. coli. CbrC is predicted to form an operon with the known Cre regulon gene, YieI (CbrB). Expression of CbrC is under control of the CreBC two-component system and it was shown to be essential for the colicin E2 tolerance.  A recent study has demonstrated the ability of the wild-type CbrC protein to bind zinc with a measured metal to protein ratio close to two, confirming the presence of two zinc binding sites.
Pfam PF03189: Otopetrin (family)
The otopetrins are a group of proteins evolutionarily conserved among metazoan . In most vertebrates there are three Otopetrin genes that encode three proteins, OTOP1, OTOP2, and OTOP3. All form proton-selective ion channels that allow influx of protons into cells . The structure of otopetrin-1 (Q80VM9) shows it to have 12 transmembrane domains, with three conserved sub-domains (OD-1 to OD-III) . Otopetrins were initially thought to modulate calcium homeostasis and influx of calcium in response to extracellular ATP  but were subsequently shown to form proton-selective ion channels .
Wikipedia: The otopetrin family is a group of proteins that were first identified based on their essential role in the vestibular system, and were later shown to form proton-selective ion channels expressed in many different tissues, including taste receptor cells. They are named after the Greek word "o̱tós," which means ear and "pétrā," which means rock, in reference to their role in the formation of otoconia/otoliths in the inner ear.
Pfam PF10958: Protein of unknown function (DUF2759) (family)
This family of proteins with unknown function appear to be restricted to Bacillaceae.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF08545: 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III (domain)
This domain is found on 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III [ec:2.3.1.180], the enzyme responsible for initiating the chain of reactions of the fatty acid synthase in plants and bacteria.
Wikipedia: In enzymology, a β-ketoacyl-[acyl-carrier-protein] synthase III (EC 2.3.1.180) is an enzyme that catalyzes the chemical reactionacetyl-CoA + malonyl-[acyl carrier protein]  acetoacetyl-[acyl carrier protein] + CoA + CO2
Pfam PF18287: Integron Cassette Protein Hfx_Cass5 (domain)
This domain forms part of the integron cassette protein Hfx_CASS5 present in Vibrio cholerae. The structure of Hfx is a tetramer built from two domain-swapped dimers.
Pfam PF00329: Respiratory-chain NADH dehydrogenase, 30 Kd subunit (domain)
Respiratory-chain NADH dehydrogenase (1.6.5.3) (also known as complex I or NADH-ubiquinone oxidoreductase) is an oligomeric enzymatic complex located in the inner mitochondrial membrane which also seems to exist in the chloroplast and in cyanobacteria (as a NADH-plastoquinone oxidoreductase). Among the 25 to 30 polypeptide subunits of this bioenergetic enzyme complex there is one with a molecular weight of 30 Kd (in mammals) which has been found to be :


 * Nuclear encoded, as a precursor form with a transit peptide in mammals, and in Neurospora crassa.
 * Mitochondrial encoded in Paramecium (protein P1), and in the slime mold Dictyostelium discoideum (ORF 209).
 * Chloroplast encoded in various higher plants (ORF 159).


It is also present in bacteria:


 * In the cyanobacteria Synechocystis strain PCC 6803 (gene ndhJ).
 * Subunit C of Escherichia coli NADH-ubiquinone oxidoreductase (gene nuoC).
 * Subunit Nqo5 of Paracoccus denitrificans NADH-ubiquinone oxidoreductase. Nqo5 composes the hydrogenase-like module together with the Nqo4, Nqo6, and Nqo9 subunits. Homologous proteins of the Nqo5 subunit are also contained in membrane-bound multisubunit hydrogenases, while soluble-type hydrogenases are not. This subunit is essential in complex I assembly .
Wikipedia: Respiratory complex I, EC 7.1.1.2 is the first large protein complex of the respiratory chains of many organisms from bacteria to humans. It catalyzes the transfer of electrons from NADH to coenzyme Q10 (CoQ10) and translocates protons across the inner mitochondrial membrane in eukaryotes or the plasma membrane of bacteria.
Pfam PF21199: Laminin IV type B domain (domain)
Laminins are a major constituent of all basement membranes. The polymerisation of laminins at the cell surface is mediated by the three short arms of the cross-shaped laminin heterotrimer. The short arms contain repeats of laminin-type epidermal growth factor-like (LE) domains, interspersed with globular domains. This domain consists of a beta-sandwich related to bacterial family 35 carbohydrate binding modules, and more distantly to the L4 domains present in the short arms of laminin alpha and gamma chains.
Pfam PF08624: Chromatin remodelling complex Rsc7/Swp82 subunit (family)
This family has been identified as a subunit of chromatin remodelling complexes.  Saccharomyces cerevisiae [swissprot:P32832] and its paralogue [swissprot:P43554] have been identified as subunits of the RSC chromatin remodelling complex, and SWI/SNF chromatin remodelling complex respectively.
Pfam PF17892: Cadherin-like domain (domain)
This cadherin-like domain is found in a variety of uncharacterized proteins.
Pfam PF24184: Phage zinc binding protein (domain)
This entry contains a set of uncharacterised phage proteins. These proteins are likely to bind to Zn ions using three conserved cysteines and a histidine.
Pfam PF06320: GCN5-like protein 1 (GCN5L1) (family)
This family consists of several eukaryotic GCN5-like protein 1 (GCN5L1) sequences. GCN5L1, also known as BLOC1S1 (biogenesis of lysosome-related organelles complex 1 subunit 1). It is a component of the BLOC-1 complex, a complex required for normal biogenesis of lysosome-related organelles.
Pfam PF22283: Family of unknown function (DUF6960) (family)
This is a family of uncharacterised bacterial proteins. They are composed of two tandem domains with similarity to SH3 domains, in particular to YorP.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF21404: Phosphoacetylglucosamine mutase AMG1, domain III (domain)
Phosphoacetylglucosamine mutase (AMG1) catalyses the conversion of GlcNAc-6-P into GlcNAc-1-P during the synthesis of uridine diphosphate/UDP-GlcNAc. It consists of four domains, the first three have the same fold of four beta-strands between two alpha-helices. This entry represents domain III of eukaryotic AMG1, which contains the sugar-binding loop.
Pfam PF00599: Influenza Matrix protein (M2) (family)
This protein spans the viral membrane with an extracellular amino-terminus external and a cytoplasmic carboxy-terminus.
Wikipedia: The Matrix-2 (M2) protein is a proton-selective viroporin, integral in the viral envelope of the influenza A virus. The channel itself is a homotetramer, where the units are helices stabilized by two disulfide bonds, and is activated by low pH. The M2 protein is encoded on the seventh RNA segment together with the M1 protein. Proton conductance by the M2 protein in influenza A is essential for viral replication.
Pfam PF24013: Family of unknown function (DUF7327) (family)
This entry represents a small family of uncharacterised phage proteins.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF23738: Zona pellucida sperm-binding protein 2, Ig-like domain (domain)
This domain is found at the N-terminal end of Zona pellucida sperm-binding protein 2 (ZP2) from mouse and similar proteins from vertebrates. ZP2 is a component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilisation polyspermy. This protein is thought to act as a secondary sperm receptor. This domain adopts an immunoglobulin-like (Ig-like) fold.
Pfam PF16905: Voltage-dependent L-type calcium channel, IQ-associated (family)
GPHH is a sequence motif found in this short domain on voltage-dependent L-type calcium channel proteins in eukaryotes. The domain is closely associated with the IQ-domain, [pfam:PF08763].
Pfam PF20781: TssR C-terminal domain (domain)
This entry represents the C-terminal domain from the TssR protein.  T6SSs are toxin delivery systems. It is a multiprotein complex requiring numerous core proteins (Tss proteins) including cytoplasmic, transmembrane, and outer membrane components. The needle or tube apparatus is comprised of a phage-like complex, similar to the T4 contractile bacteriophage tail, which is thought to be anchored to the membrane by a trans-envelope complex.
Pfam PF02207: Putative zinc finger in N-recognin (UBR box) (family)
This region is found in E3 ubiquitin ligases that recognise N-recognins.
Pfam PF10815: ComZ (family)
ComZ is part of a two gene operon. It affects competence regulation by negatively affecting the transcription of the ComG operon. ComZ contains a leucine zipper motif.
Pfam PF15937: prlF antitoxin for toxin YhaV_toxin (family)
PrlF_antitoxin is a family of bacterial antitoxins that neutralises the toxin YhaV. PrlF is labile and forms a homodimer that then binds to the YhaV toxin thereby neutralising its ribonuclease activity. Alone, it can also act as a transcription factor. The YhaV/PrlF complex binds the prlF-yhaV operon, probably regulating its expression negatively. Over-expression of PrlF leads to increased doubling time.
Wikipedia: A toxin-antitoxin system consists of a "toxin" and a corresponding "antitoxin", usually encoded by closely linked genes. The toxin is usually a protein while the antitoxin can be a protein or an RNA. Toxin-antitoxin systems are widely distributed in prokaryotes, and organisms often have them in multiple copies. When these systems are contained on plasmids – transferable genetic elements – they ensure that only the daughter cells that inherit the plasmid survive after cell division. If the plasmid is absent in a daughter cell, the unstable antitoxin is degraded and the stable toxic protein kills the new cell; this is known as 'post-segregational killing' (PSK).