SII-SWORD/CoKE huggingface dataset:
Pfam PF09071: Alpha-amylase, C terminal (domain)
Members of this family, which are found in the prokaryotic protein glycosyltrehalose trehalohydrolase, assume a gamma-crystallin-type fold with a five-stranded anti-parallel beta-sheet that packs against the C-terminal side of a beta-alpha barrel. This domain is common to family 13 glycosidases and typically contains a five to ten strand beta-sheet, however its precise fold varies.
Pfam PF07998: Peptidase family M54 (family)
This is a family of metallopeptidases.  Two human proteins have been reported to degrade synthetic substrates and peptides.
Pfam PF15124: FANCD2 opposite strand protein (family)
This family of proteins of unknown function gets its  name from its position in the mammalian genome: Fanconi  anemia group D2 protein opposite strand transcript protein.
Pfam PF15320: mRNA cap methylation, RNMT-activating mini protein (family)
This family of proteins is found in eukaryotes. Proteins in this family are typically between 102 and 154 amino acids in length. There is a single completely conserved residue D that may be functionally important.  RAM is a family of eukaryotic proteins that are an obligate component of the mammalian cap methyltransferase, RNMT (RNA guanine-7 methyltransferase). RAM consists of an N-terminal RNMT-activating domain and a C-terminal RNA-binding domain. Either RAM or RNMT independently have rather weak binding affinity for RNA, but together their RNA affinity is significantly increased. RAM is necessary for efficient cap methylation, maintaining mRNA expression levels, for mRNA translation and for cell viability.
Pfam PF17669: Family of unknown function (DUF5529) (family)
This is a family of unknown function found in Chordata.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF10846: Protein of unknown function (DUF2722) (family)
This eukaryotic family of proteins has no known function.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF10927: Protein of unknown function (DUF2738) (family)
This is a viral family of proteins with unknown function.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF07856: Mediator of CRAC channel activity (family)
ORAI-1 is a protein homologue of Drosophila Orai and human Orai1, Orai2 and Orai3. ORAI-1 GFP reporters are co- expressed with STIM-1 (ER CA(2+) sensors) in the gonad and intestine. The protein has four predicted transmembrane domains with a highly conserved region between TM2 ad TM3. This conserved domain is thought to function in channel regulation. ORAI1- related proteins are required for the production of the calcium channel, CRAC, along with STIM1-related proteins.
Wikipedia: Calcium release-activated channels (CRAC) are specialized plasma membrane Ca2+ ion channels. When calcium ions (Ca2+) are depleted from the endoplasmic reticulum (a major store of Ca2+) of mammalian cells, the CRAC channel is activated to slowly replenish the level of calcium in the endoplasmic reticulum. The Ca2+ Release-activated Ca2+ (CRAC) Channel (CRAC-C) Family (TC# 1.A.52) is a member of the Cation Diffusion Facilitator (CDF) Superfamily. These proteins typically have between 4 and 6 transmembrane α-helical spanners (TMSs). The 4 TMS CRAC channels arose by loss of 2TMSs from 6TMS CDF carriers, an example of 'reverse' evolution'.
Pfam PF13710: ACT domain (domain)
ACT domains bind to amino acids and regulate associated enzyme domains. These ACT domains are found at the C-terminus of the RelA protein.
Pfam PF14016: Domain of unknown function (DUF4232) (domain)
This entry represents a domain of unknown function found in uncharacterised bacterial proteins. Many members of this entry are thought to be lipoproteins. This domain may adopt a Ig-like fold.
Pfam PF22326: E3 SUMO-protein ligase MMS21, N-terminal domain (domain)
This domain is found at the N-terminal end of E3 SUMO-protein ligase MMS21 from Saccharomyces cerevisiae and similar fungal proteins. MMS21 acts in a DNA repair pathway for removal of UV-induced DNA damage that is distinct from classical nucleotide excision repair and in repair of ionizing radiation damage. This domain forms an helix bundle with a coiled-coil structure. It is required for the binding to Smc5, which is essential for cell growth and resistance to DNA damage.
Pfam PF10160: Predicted membrane protein (family)
This is a region of 280 amino acids from a group of proteins conserved from plants to humans. It is predicted to be a membrane protein but its function is otherwise unknown.
Pfam PF01330: RuvA N terminal domain (domain)
The N terminal domain of RuvA has an OB-fold structure. This domain forms the RuvA tetramer contacts.
Pfam PF20723: Pellino, RING domain (domain)
Pellino proteins are E3 ubiquitin ligases that play an important role in immunity, being involved in Toll-like signalling pathways, and associates with the kinase domain of the Pelle Ser/Thr kinase. Mammalian Pellinos have been shown to mediate polyubiquitination of interleukin-1 receptor-associated kinase (IRAK). These proteins consist of a forkhead-associated (FHA) domain at the N-terminal and a C-terminal RING domain. This is the RING domain which is not required for interaction with phosphorylated IRAK1.
Pfam PF23986: Phage Pam3 gp59 related protein (family)
This entry represents a small family of proteins that is related to phage Pam3 gp59 protein. The function of this protein is unknown.
Pfam PF17464: Non-structural protein 11 and 12 (family)
This is a domain of unknown function found in Phytoreovirus. Family members include the Rice dwarf virus Pns11 and Pns12. Rice dwarf virus (RDV) is an icosahedral, double-layered particle. The viral genome consists of 12 segmented dsRNAs that encode seven structural (P1, P2, P3, P5, P7, P8 and P9) and five non-structural (Pns4, Pns6, Pns10, Pns11 and Pns12) proteins. Pns11 is known to bind nucleic acids and Pns12 is a phosphorylated protein. The non-structural proteins Pns6, Pns11 and Pns12 of RDV are the major constituents of the matrix of viral inclusions in which the assembly of progeny virions and the synthesis of viral RNA are thought to occur.
Pfam PF16044: DUF4796 C-terminal (domain)
This domain is functionally uncharacterised and is found in eukaryotes. Proteins with this domain are typically between 194 and 289 amino acids in length. There is a single completely conserved residue C that may be functionally important. This domain has been identified as structurally similar to peptidase C97 domain ([pfam:PF05903]).
Pfam PF10971: Protein of unknown function (DUF2773) (family)
This family of proteins with unknown function appears to be restricted to Enterobacteriaceae.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF12331: Rad26-like, helical repeats (repeat)
This domain is found in Rad26 from Myceliophthora thermophila ([swissprot:G2QDY6]) and similar fungal proteins. Rad26 is a functional subunit of the Rad3-Rad26 complex that is responsible for bringing the kinase to sites of DNA damage. The central region of Rad26 is formed by five helical repeats forming an alpha-solenoid arrangement.
Pfam PF22218: SAS-6, C-terminal coiled coil (domain)
This domain is found at the C-terminal end of SAS-6 from Leishmania major ([swissprot:E9AFQ5]) and similar sequences found in protists. SAS-6 is a centriolar protein that oligomerises through its coiled coil (CC) domain (this entry), forming a rod-like parallel dimer.
Pfam PF02942: Influenza B non-structural protein (NS1) (family)
A specific region of the influenza B virus NS1 protein, which includes part of its effector domain, blocks the covalent linkage of ISG15 [swissprot:Q64339] to its target proteins both in vitro and in infected cells. Of the several hundred proteins induced by interferon (IFN) alpha/beta, the ubiquitin-like ISG15 protein is one of the most predominant. Influenza A virus employs a different strategy: its NS1 protein does not bind the ISG15 protein, but little or no ISG15 protein is produced during infection.
Pfam PF17206: SeqA protein N-terminal domain (domain)
The binding of SeqA protein to hemimethylated GATC sequences is important in the negative modulation of chromosomal initiation at oriC, and in the formation of SeqA foci necessary for Escherichia coli chromosome segregation. SeqA tetramers are able to aggregate or multimerise in a reversible, concentration-dependent manner. Apart from its function in the control of DNA replication, SeqA may also be a specific transcription factor. This short domain mediates dimerisation.
Wikipedia: In molecular biology the SeqA protein is found in bacteria and archaea. The function of this protein is highly important in DNA replication. The protein negatively regulates the initiation of DNA replication at the origin of replication, in Escherichia coli, OriC. Additionally the protein plays a further role in sequestration. The importance of this protein is vital, without its help in DNA replication, cell division and other crucial processes could not occur. This protein domain is thought to be part of a much larger protein complex which includes other proteins such as SeqB.
Pfam PF00287: Sodium / potassium ATPase beta chain (family)
This entry represents the sodium/potassium-transporting ATPase subunit beta. This is the non-catalytic component of the active enzyme, which catalyses the hydrolysis of ATP coupled with the exchange of Na+and K+ions across the plasma membrane. The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane .
Pfam PF01982: Domain of unknown function DUF120 (domain)
This domain is a CTP-dependent riboflavin kinase (RFK), found in archaea, that catalyses the phosphorylation of riboflavin to form flavin mononucleotide in riboflavin biosynthesis [ec:2.7.1.26]. Its structure resembles a RIFT barrel, structurally similar to but topologically distinct from bacterial and eukaryotic examples. The N-terminal is a winged helix-turn-helix DNA-binding domain, and the C-terminal half is most similar in sequence to a group of cradle-loop barrels. [swissprot:O28174] has this domain attached to [pfam:PF00325].
Pfam PF00720: Subtilisin inhibitor-like (domain)
The Streptomyces family of bacteria produce a number of proteinase inhibitors, which belong to MEROPS inhibitor family I16, clan IY. They are characterised by their strong activity towards subtilisin (MEROPS peptidase family S8, IPR000209) and are collectively known as Streptomyces subtilisin inhibitors (SSI). Some SSI also inhibit trypsin, chymotrypsin (MEROPS peptidase family S1, IPR001254) and griselysin (MEROPS peptidase family M4, IPR001570) . Mutation of the active site residue can influence inhibition specificity .

SSI is a homodimer, each monomer containing 2 anti-parallel Î²-sheets and 2 short Î±-helices. Protease binding induces the widening of a channel-like structure, in which hydrophobic side-chains are sandwiched between 2 lobes . Loss of the C-terminal tetrapeptide VFAF drastically reduces the inhibitory effect of the proteins when there is less than one molecule of inhibitor present per molecule of enzyme. This implies that the tetrapeptide is neccessary to maintain the correct 3D fold . Structural similarities between the primary and secondary contact loops of SSI, and the ovomucoid and pancreatic secretory trypsin inhibitor family suggest evolution of the 2 families from a common ancestor .
Wikipedia: In molecular biology the protein SSI is a Subtilisin inhibitor-like which stands for Streptomyces subtilisin inhibitor. This is a protease inhibitor. These are often synthesised as part of a larger precursor protein, either as a prepropeptide. The function of this protein domain is to prevent access of the substrate to the active site. It is found only in bacteria.
Pfam PF13374: Tetratricopeptide repeat (repeat)
Wikipedia: The tetratricopeptide repeat (TPR) is a structural motif. It consists of a degenerate 34 amino acid tandem repeat identified in a wide variety of proteins. It is found in tandem arrays of 3–16 motifs, which form scaffolds to mediate protein–protein interactions and often the assembly of multiprotein complexes. These alpha-helix pair repeats usually fold together to produce a single, linear solenoid domain called a TPR domain. Proteins with such domains include the anaphase-promoting complex (APC) subunits cdc16, cdc23 and cdc27, the NADPH oxidase subunit p67-phox, hsp90-binding immunophilins, transcription factors, the protein kinase R (PKR), the major receptor for peroxisomal matrix protein import PEX5, protein arginine methyltransferase 9 (PRMT9), and mitochondrial import proteins.
Pfam PF19997: vWA domain found in the FtsH ternary systems (domain)
Highly-divergent vWA domain lacking metal-chelating aspartates of typical vWA domains. Core component of the FtsH ternary systems, a class of NTP-dependent biological conflict systems.
Pfam PF22295: Family of unknown function (DUF6967) (family)
This family of proteins is found in bacteria. Proteins in this family are approximately 70 amino acids in length. They are predicted to fold into a four-stranded beta-sheet meander and an alpha-helix. One face of this beta-sheet is enriched with conserved positively charged arginine and lysine residues.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF21743: PTM/DIR17-like, Tudor domain (domain)
This entry represents the Tudor domain of PTM and DIR17 from Arabidopsis thaliana. AtPTM, also called DDT domain-containing protein 1, is a membrane-bound transcription factor required for plastid-to-nucleus retrograde signaling. AtDIR17 imparts stereoselectivity on the phenoxy radical-coupling reaction, yielding optically active lignans from two molecules of coniferyl alcohol in the biosynthesis of lignans, flavonolignans, and alkaloids, and thus plays a central role in plant secondary metabolism.
Pfam PF24450: Family of unknown function (DUF7566) (family)
This entry represents a family of uncharacterised proteins from phage. Structure predictions suggest the protein is composed of a larger N-terminal domain with an 8 stranded beta sheet. Followed by a C-terminal helical domain.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF15802: DDB1- and CUL4-associated factor 17 (repeat)
DCAF17, DDB1- and CUL4-associated factor 17, is a family of proteins found in eukaryotes.  It may function as a substrate-receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex. Mutations in the human protein, otherwise known as C2orf37, are responsible for Woodhouse-Sakati Syndrome. Woodhouse-Sakati Syndrome is a rare autosomal recessive multi-systemic disorder characterised by hypogonadism, alopecia, diabetes mellitus, mental retardation, and extrapyramidal syndrome.
Pfam PF20993: CENPH protein (family)
This protein is part of the yeast kinetochore, a multiprotein complex that assembles on centromeric DNA and attaches chromosomes to spindle microtubules.
Pfam PF07331: Tripartite tricarboxylate transporter TctB family (family)
This family consists of several hypothetical bacterial proteins of around 150 residues in length. This family was formerly known as DUF1468.
Pfam PF19832: Family of unknown function (DUF6313) (family)
This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0000703) is described by MIBiG as an example of the following biosynthetic class, saccharide, in particular the  kanamycin biosynthetic gene cluster from Streptomyces kanamyceticus.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF21386: Integrator IntS11, C-terminal domain (domain)
IntS11 is the catalytic component of integrator complex (INT), which is involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. This is the C-terminal domain of IntS11 which interacts with the C-terminal of IntS9 ([pfam:PF21382]), which is  a crucial interaction for the role of INT in snRNA 3'-end processing. IntS11 is responsible of the endonuclease activity of INT.
Pfam PF00154: recA bacterial DNA recombination protein (family)
RecA is a DNA-dependent ATPase and functions in DNA repair systems.  RecA protein catalyses an ATP-dependent DNA strand-exchange reaction that is the central step in the repair of dsDNA breaks by homologous recombination.
Wikipedia: RecA is a 38 kilodalton protein essential for the repair and maintenance of DNA in bacteria. Structural and functional homologs to RecA have been found in all kingdoms of life. RecA serves as an archetype for this class of homologous DNA repair proteins. The homologous protein is called RAD51 in eukaryotes and RadA in archaea.
Pfam PF25024: Teneurin EGF domain (domain)
Teneurins are ancient cell-cell adhesion receptors that are vital for brain development and synapse organisation. This entry represents the EGF domain which provides covalent cis-interaction functionality to these proteins, forming cis dimers are highly flexible. Teneurins contain eight repeats of EGFs similar to the extracellular matrix protein tenascin, also included in this entry.
Pfam PF11436: Protein of unknown function (DUF3199) (family)
Some members in this family of proteins with unknown function are annotated as YqbG however this cannot be confirmed. Currently the proteins has no known function.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF23654: E3 ubiquitin-protein ligase LIN-like, ARM repeat (repeat)
This region of armadillo-like repeats is found in a group of plant proteins, including E3 ubiquitin-protein ligase LIN from soybean. It is often found C-terminal to [pfam:PF23568].
Pfam PF01210: NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus (family)
NAD-dependent glycerol-3-phosphate dehydrogenase (GPDH) catalyses the interconversion of dihydroxyacetone phosphate and L-glycerol-3-phosphate. This family represents the N-terminal NAD-binding domain.
Wikipedia: Glycerol-3-phosphate dehydrogenase (GPDH) is an enzyme that catalyzes the reversible redox conversion of dihydroxyacetone phosphate to sn-glycerol 3-phosphate.
Pfam PF15946: Domain of unknown function (DUF4754) (family)
This family of proteins is found in bacteria. Proteins in this family are approximately 80 amino acids in length.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF20582: UPF0758 N-terminal (domain)
This domain is functionally uncharacterised, found at the N-terminal of the uncharacterised UPF0758 proteins from bacteria and archaea, and is approximately 90 amino acids in length. UPF0758 was previously known as the radC family, a name that was assigned according to the radC102 mutant of E. coli which was later demonstrated to be an allele of the transcription-repair-coupling factor recG. UPF0758 has been described as a putative JAMM-family deubiquitinating enzyme, but its function remains to be determined. Structure prediction using Colab notebook from AlphaFold DB suggests that it has an alpha bundle fold. It may contain two helix-hairpin-helix (HhH) motifs. This domain is found in association with [pfam:PF04002].
Pfam PF19185: Family of unknown function (DUF5867) (family)
This is a family of uncharacterised proteins of unknown function predominantly found in viruses.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF15264: Tumour suppressing sub-chromosomal transferable candidate 4 (family)
This family of proteins is expressed from a gene cluster where in humans the TSSC4 gene is not imprinted. This same cluster is associated with the Beckwith-Wiedermann syndrome. This domain family is found in eukaryotes, and is typically between 120 and 147 amino acids in length. There is a conserved YSL sequence motif.
Pfam PF03476: MOSC N-terminal beta barrel domain (domain)
This domain is found to the N-terminus of [pfam:PF03473]. The function of this domain is unknown, however it is predicted to adopt a beta barrel fold.