SII-SWORD/CoKE huggingface dataset:
Pfam PF17405: Nrap protein nucleotidyltransferase domain 4 (domain)
Members of this family are nucleolar RNA-associated proteins (Nrap) which are highly conserved from yeast (Saccharomyces cerevisiae) to human. In the mouse, Nrap is ubiquitously expressed and is specifically localised in the nucleolus. Nrap is a large nucleolar protein (of more than 1000 amino acids). Nrap appears to be associated with ribosome biogenesis by interacting with pre-rRNA primary transcript.
Pfam PF14442: Bd3614-like deaminase N-terminal (family)
This is a globular domain that occurs N-terminal to the Bd3614-like deaminases, which are predicted to be involved in RNA editing.
Pfam PF11313: Protein of unknown function (DUF3116) (family)
This family of proteins with unknown function appears to be restricted to Bacillales.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF18398: Clip-domain serine protease homolog masquerade (domain)
The clip domain is a structural/regulatory unit in many arthropod serine proteases. The clip domain super-family also includes serine protease homologs (SPHs). This entry describes clip domains in the SPHs (CLIP subfamily A), which belong to group-3. SPHs usually carry between 1 to 5 clip domains. One of the most prominent family members is masquerade (mas). Deletion in drosophila models lead to defects in somatic muscle attachment and in the formation of the nervous system during embryogenesis.
Pfam PF19623: Family of unknown function (DUF6128) (family)
This presumed domain is functionally uncharacterised. This domain family is found in bacteria, and is approximately 110 amino acids in length.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF07298: NnrU protein (domain)
This domain is found in several plant and bacterial NnrU proteins. NnrU is thought to be involved in the reduction of nitric oxide. The exact function of NnrU is unclear. It is thought however that NnrU and perhaps NnrT are required for expression of both nirK and nor.
Pfam PF13273: Protein of unknown function (DUF4064) (family)
This presumed domain is functionally uncharacterised.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF16467: Domain of unknown function (DUF5048) (family)
This family consists of C-terminal of several uncharacterized proteins around 500 residues in length and is mainly found in various Faecalibacterium and Clostridium species. The function of this family is unknown.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF06134: L-rhamnose isomerase (RhaA) (domain)
This family consists of several bacterial L-rhamnose isomerase proteins ([ec:5.3.1.14]).
Pfam PF11268: Protein of unknown function (DUF3071) (family)
Some members in this family of proteins are annotated as DNA-binding proteins however this cannot be confirmed. Currently no function is known.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF15562: Immunity protein 17 (family)
A predicted immunity protein with two transmembrane helices, and a WxW motif and a conserved arginine between the two helices. Proteins containing this domain are present in heterogeneous poly-immunity loci in polymorphic toxin systems.
Pfam PF17105: C-terminal domain of bromodomain protein 4 (family)
BRD4_CDT is the short highly conserved C-terminal domain of certain bromodomain proteins, notably Brd4. The Brd4 CTD interacts with the cyclin T1 and Cdk9 subunits of positive transcription elongation factor b (pTEFb) complex. Brd4 displaces negative regulators, the HEXIM1 and 7SKsnRNA complex, from pTEFb, thereby transforming it into an active form that can phosphorylate RNA pol II.
Pfam PF12827: Peroxisomal biogenesis protein family (family)
Peroxin-22 is a integral peroxisomal membrane protein family. The N-terminus is in the matrix and the C-terminus is in the cytosol. The N-terminus carries a 25-amino acid peroxisome membrane-targeting signal. It interacts with the ubiquitin-conjugating peripheral peroxisomal membrane enzyme Pex4p anchoring it at the peroxisomal membrane. Both Pex proteins are involved at the same stage of peroxisome biogenesis. Pex22p-Pex4p interaction is required for ubiquitination of peroxisomal import receptor Pex5p mediated by Pex4p.
Pfam PF02287: Dehydratase small subunit (domain)
This family contains the small subunit of the trimeric diol dehydratases and glycerol dehydratases. These enzymes are produced by some enterobacteria in response to growth substances.
Pfam PF04880: NUDE protein, C-terminal conserved region (family)
This family represents the C-terminal conserved region of the NUDE proteins. NUDE proteins are involved in nuclear migration.
Pfam PF24886: Domain of unknown function (DUF7740) (domain)
This entry represents a family of phage proteins. The core structure of these proteins is a conserved four helix bundle. The function of these proteins is unknown.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF24658: Domain of unknown function (DUF7647) (domain)
This domain is found in uncharacterised proteins mainly from plants. It is predicted to adopt a globular structure consisting of array of helices.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF03451: HELP motif (repeat)
The founding member of the EMAP protein family is the 75 kDa Echinoderm Microtubule-Associated Protein, so-named for its abundance in sea urchin, sand dollar and starfish eggs. The Hydrophobic EMAP-Like Protein (HELP) motif was identified initially in the human EMAP-Like Protein 2 (EML2) and subsequently in the entire EMAP Protein family.  The HELP motif is approximately 60-70 amino acids in length and is conserved amongst metazoans. All members of the EMAP-Like Protein family, identified to-date, are constructed with an amino terminal HELP motif followed by two beta-propellers which were defined as TAPE (tandem atypical propeller in EMls) domain. This motif is part  of the hydrophobic core that joints the two beta-propellers, contributing blades 1 and 14 that are buried at the interface between them. In C. elegans, EMAP-Like Protein-1 (ELP-1) is required for touch sensation indicating that ELP-1 may play a role in mechanosensation. The localization of ELP-1 to microtubules and adhesion sites implies that ELP-1 may transmit forces between the body surface and the touch receptor neurons.
Pfam PF08631: Meiosis protein SPO22/ZIP4 like (repeat)
SPO22/ZIP4 in yeast is a meiosis specific protein involved in sporulation.  It has been shown to regulate crossover distribution by promoting synaptonemal complex formation.
Pfam PF07200: Modifier of rudimentary (Mod(r)) protein (domain)
This family represents a conserved region approximately 150 residues long within a number of eukaryotic proteins that show homology with Drosophila melanogaster Modifier of rudimentary (Mod(r)) proteins. The N-terminal half of Mod(r) proteins is acidic, whereas the C-terminal half is basic, and both of these regions are represented in this family.  Members of this family include the Vps37 subunit of the endosomal sorting complex ESCRT-I, a complex involved in recruiting transport machinery for protein sorting at the multivesicular body (MVB). The yeast ESCRT-I complex consists of three proteins (Vps23, Vps28 and Vps37).  The mammalian homologue of Vps37 interacts with Tsg101 (Pfam: PF05743) through its mod(r) domain and its function is essential for lysosomal sorting of EGF receptors.
Pfam PF09426: Vacuolar R-SNARE Nyv1, longin domain (domain)
This domain corresponds to the N terminal longin domain of vacuolar R-SNARE Nyv1 which contains YXXomega-like sorting motif (Y31GTI34), responsible for the AP3-dependent vacuolar localization of Nyv1.
Pfam PF06779: Uncharacterised MFS-type transporter YbfB (family)
This family represents putative bacterial membrane proteins which may be sugar transporters. Members carry twelve transmembrane regions which are characteristic of members of the major facilitator sugar-transporter superfamily.
Pfam PF08334: Type II secretion system (T2SS), protein G (family)
The Type II secretion system, also called Secretion-dependent pathway (SDP), is responsible for the transport of proteins across the outer membrane first exported to the periplasm by the Sec or Tat translocon in Gram-negative (diderm) bacteria. The T2SG family includes proteins such as EpsG (P45773) in Vibrio cholera, XcpT also called PddA (Q00514) in Pseudomonas aeruginosa or PulG (P15746)in Klebsiella pneumoniae. The PulG is thought to be anchored in the inner membrane with its C-terminus directed towards the periplasme. Together with other members of the Type II secretion machinery, it is thought to assemble into a pilus-like structure that may function as a dynamic mechanism to push secreted proteins out of the cell. The polypeptide is organized into a long N-terminal alpha-helix followed by a loop region that separates it from a C-terminal anti-parallel beta-sheet.
Pfam PF03969: AFG1-like ATPase (family)
This P-loop motif-containing family of proteins includes AFG1, LACE1 and ZapE. ATPase family gene 1 (AFG1) is a 377 amino acid yeast protein with an ATPase motif typical of the family. LACE1, the  mammalian homologue of AFG1, is a mitochondrial integral membrane protein that is essential for maintenance of fused mitochondrial reticulum and lamellar cristae morphology. It has also been demonstrated that LACE1 mediates degradation of nuclear-encoded complex IV subunits COX4 (cytochrome c oxidase 4), COX5A and COX6A, and is required for normal activity of complexes III and IV of the respiratory chain. ZapE is a cell division protein found in Gram-negative bacteria. The bacterial cell division process relies on the assembly, positioning, and constriction of FtsZ ring (the so-called Z-ring), a ring-like network that marks  the future site of the septum of bacterial cell division. ZapE is a Z-ring associated protein required for cell division under low-oxygen conditions. It is an ATPase that appears at the constricting Z-ring late in cell division. It reduces the stability of FtsZ polymers in the presence of ATP in vitro.
Pfam PF08563: P53 transactivation motif (conserved_site)
The binding of the p53 transactivation domain by regulatory proteins regulates p53 transcription activation.  This motif is comprised of a single amphipathic alpha helix and contains a highly conserved sequence.
Wikipedia: 
p53, also known as Tumor protein P53, cellular tumor antigen p53, or transformation-related protein 53 (TRP53) is a regulatory protein that is often mutated in human cancers. The p53 proteins are crucial in vertebrates, where they prevent cancer formation. As such, p53 has been described as "the guardian of the genome" because of its role in conserving stability by preventing genome mutation. Hence TP53 is classified as a tumor suppressor gene.
Pfam PF12233: Human adult T cell leukemia/lymphoma virus protein (family)
This family of proteins is found in viruses. Proteins in this family are approximately 100 amino acids in length. p12I binds to the immature beta and gamma-c chains of the interleukin-2 receptor retarding their translocation to the plasma membrane. p12I forms dimers which bind to these chains.
Pfam PF11638: DnaA N-terminal domain (domain)
This family of proteins represents the N-terminal domain of DnaA, a protein involved in the initiation of bacterial chromosomal replication. The structure of this domain is known. It is also found in three copies in some proteins such as [swissprot:B5V0X4]. The exact function of this domain is uncertain but it has been suggested to play a role in oligomerisation.
Pfam PF18488: WYL domain (domain)
Many phytopathogens secrete and/or inject 'effector' proteins inside host cells to modulate cellular processes. Phytopathogens deliver effector proteins inside host plant cells to promote infection. Crystal structures of the effector domains from two oomycete RXLR proteins, Phytophthora capsici AVR3a11 and Phytophthora infestans PexRD2 reveal a core alpha-helical fold (termed the 'WY-domain') which enables functional adaptation of these fast evolving effectors through (i) insertion/deletions in loop regions between alpha-helices, (ii) extensions to the N and C termini, (iii) amino acid replacements in surface residues, (iv) tandem domain duplication, and (v) oligomerization. It is proposed that the core fold provides both a degree of molecular stability and plasticity that enables development/maintenance of effector virulence activities while allowing evasion of recognition by the plant innate immune system during rapid 'arms race' co-evolution.
Pfam PF03485: Arginyl tRNA synthetase N terminal domain (domain)
This domain is found at the amino terminus of Arginyl  tRNA synthetase, also called additional domain 1 (Add-1). It is about 140 residues long and it has been suggested that this domain will be involved in tRNA recognition.
Wikipedia: In enzymology, an arginine—tRNA ligase is an enzyme that catalyzes the chemical reactionATP + L-arginine + tRNAArg  AMP + diphosphate + L-arginyl-tRNAArg
Pfam PF02736: Myosin N-terminal SH3-like domain (domain)
This domain has an SH3-like fold. It is found at the N-terminus of many but not all myosins. The function of this domain is unknown.
Pfam PF21391: Tyrosine decarboxylase, C-terminal (domain)
This is the C-terminal (or small) domain of tyrosine decarboxylase from Enterococcus faecalis and related species. These are PLP-dependent decarboxylases that catalyse tyrosine decarboxylation to produce tyramine. This domain may play a regulatory role.
Pfam PF10932: Protein of unknown function (DUF2783) (family)
This is a bacterial family of uncharacterised protein.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF09916: Uncharacterized protein conserved in bacteria (DUF2145) (family)
This domain, found in various hypothetical prokaryotic proteins, has no known function.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF15138: Syncollin (family)
This family has a role in zymogen granule exocytosis.
Pfam PF14387: Domain of unknown function (DUF4418) (family)
This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and archaea. Proteins in this family are typically between 132 and 150 amino acids in length.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF09483: Type III secretion protein (HpaP) (domain)
This entry represents C-terminal domain of proteins encoded by genes which are always found in type III secretion operons, although their function in the processes of secretion and virulence is unclear. Hpa stands for Hrp-associated gene, where Hrp stands for hypersensitivity response and virulence. see also [cite:PUB00109257]
Pfam PF01309: Equine arteritis virus small envelope glycoprotein (family)
Equine arteritis virus small envelope glycoprotein (Gs) is a class I transmembrane protein which adopts a number of different conformations.
Pfam PF14177: YkyB-like protein (family)
The YkyB-like protein family includes the B. subtilis YkyB protein [swissprot:P42430], which is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 150 amino acids in length. There are two conserved sequence motifs: NRHAKTA and HLG.
Pfam PF23404: FAZ1, C-terminal (repeat)
The entry represents a repeats-containing region found at the C-terminal of FAZ1 from Trypanosoma brucei brucei and related proteins from typanosomatids. FAZ1 is a component of FAZ filament that is required for correct FAZ assembly and attachment. These repeats consist of 36x14aa repeats in T.brucei and T.cruzi while in the Leishmania major LmjF34.0690 orthologue there are 70x14aa repeats.
Pfam PF20666: Centromere/kinetochore protein zw10, C-terminal (repeat)
Zw10 protein, in the context of the conserved Rod-Zwilch-Zw10 (RZZ) complex, is required for correct metaphase check-pointing during mitosis and it is also important in vesicle transport between Golgi and ER as part of a second complex together with the conserved conserved RINT1/Tip20p and NAG/Sec39p proteins. Zw10 is the metazoan homologue of yeast Dsl1, both included in the complexes associated with tethering containing helical rods (CATCHR) family, sharing structural features. This entry represents the C-terminal domain of zw10, consisting of the conserved alpha-helical bundle.
Pfam PF00077: Retroviral aspartyl protease (domain)
Single domain aspartyl proteases from retroviruses, retrotransposons, and badnaviruses (plant dsDNA viruses). These proteases are generally part of a larger polyprotein; usually pol, more rarely gag. Retroviral proteases appear to be homologous to a single domain of the two-domain eukaryotic aspartyl proteases such as pepsins, cathepsins, and renins ([pfam:PF00026]).
Wikipedia: Retroviral aspartyl proteases or retropepsins are single domain aspartyl proteases from retroviruses, retrotransposons, and badnaviruses. These proteases are generally part of a larger pol or gag polyprotein. Retroviral proteases are homologous to a single domain of the two-domain eukaryotic aspartyl proteases such as pepsins, cathepsins, and renins. Retropepsins are members of MEROPS A2, clan AA. All known members are endopeptidases.
Pfam PF17689: Arabinosyltransferase concanavalin like domain (domain)
Arabinosyltransferase is involved in arabinogalactan (AG) biosynthesis pathway in mycobacteria. AG is a component of the macromolecular assembly of the mycolyl-AG-peptidoglycan complex of the cell wall. This enzyme has important clinical applications as it is believed to be the target of the antimycobacterial drug Ethambutol.
Wikipedia: An arabinosyltransferase is a transferase enzyme acting upon arabinose.
This enzyme is involved in polymerisation of arabinogalactan. Mycobacterially, the more precise term is arabinofuranosyltransferase, since the arabinose residues occur only in a furanose form.
Pfam PF05386: TEP1 N-terminal domain (domain)
This short sequence region is found in four copies at the N-terminus of the TEP1 telomerase component. The functional significance of the region is uncertain.  However the conservation of two histidines and a cysteine suggests it is a potential zinc binding domain.
Pfam PF24952: Domain of unknown function (DUF7761) (domain)
This domain is found in uncharacterised proteins mainly from flagellate Discoba.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF21191: CvfB first S1-like domain (domain)
CvfB is a conserved regulatory protein important for the virulence of Staphylococcus aureus. This entry represents the first of three S1-like OB-fold domains.
Pfam PF03766: Remorin, N-terminal region (family)
Remorins are plant-specific plasma membrane-associated proteins. In tobacco remorin co-purifies with lipid rafts. Most remorins have a variable, proline-rich C-half and a more conserved N-half that is predicted to form coiled coils. Consistent with this, circular dichroism studies have demonstrated that much of the protein is alpha-helical. Remorins exist in plasma membrane preparations as oligomeric structures and form filaments in vitro. The proteins can bind polyanions including the extracellular matrix component oligogalacturonic acid (OGA). In vitro, remorin in plasma membrane preparations is phosphorylated (principally on threonine residues) in the presence of OGA and thus co-purifies with a protein kinases(s). The biological functions of remorins are unknown but roles as components of the membrane/cytoskeleton are possible.