SII-SWORD/CoKE huggingface dataset:
Pfam PF24639: Domain of unknown function (DUF7634) (domain)
This is a presumed beta-sandwich domain found near the central region of uncharacterised sequences from Plasmodium falciparum (SwissProt:Q8IBR8) and similar sequences from Apicomplexa.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF09683: Bacteriocin (Lactococcin_972) (family)
These sequences represent bacteriocins related to lactococcin. Members tend to be found in association with a seven transmembrane putative immunity protein.
Wikipedia: Bacteriocins are proteinaceous or peptidic toxins produced by bacteria to inhibit the growth of similar or closely related bacterial strain(s). They are similar to yeast and paramecium killing factors, and are structurally, functionally, and ecologically diverse. Applications of bacteriocins are being tested to assess their application as narrow-spectrum antibiotics.
Pfam PF20310: Transposon related HTH domain protein (family)
This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 103 and 265 amino acids in length. This protein contains a helix-turn-helix motif that is likely to be DNA-binding.
Pfam PF15934: Yuri gagarin (family)
The yuri gagarin protein found in Drosophila, it plays roles in spermatogenesis.
Pfam PF23170: Period circadian protein homolog bHLH-like domain (domain)
This domain is found in the family of Period circadian protein homologs (PER1, PER2, PER3). These proteins are transcriptional repressors which form the core component of the circadian clock. They play a critical role in rhythm generation, whereas delays imposed by post-translational modifications are important for determining the period of the rhythms. The core clock genes: PER1/2/3 and CRY1/2 form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-BMAL1|BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This domain is a bHLH domain which know to interact with DNA. It is more closely related to Circadian locomoter output cycles protein kaput (Clock).
Pfam PF13310: Virulence protein RhuM family (family)
There are currently no experimental data for members of this group or their homologues. However, these proteins are implicated in virulence/pathogenicity because RhuM is encoded in the SPI-3 pathogenicity island in Salmonella typhimurium.
Pfam PF24054: Domain of unknown function (DUF7357) (domain)
This domain is found in uncharacterised proteins mainly from fungi. It is predicted to fold into a globular structure with ubiquitin-like topology elaborated with long loops. It is frequently found in combination with [pfam:PF23086].
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF20925: Huntingtin, bridge (repeat)
HTT is expressed in many tissues, with various expression levels and is involved in a number of cellular functions. However, its exact function is not yet clear. An an abnormal polyglutamine (polyQ) expansion in this protein causes Huntington's disease (HD) a progressive autosomal-dominant neurodegenerative disease characterised by an uncontrolled motor movement known as chorea, cognitive disorder and depression. HTT consists of multiple HEAT repeats organised in N-terminal, bridge (represented in this entry) and C-terminal domains, which function as a scaffold that mediates interactions with binding partners. This domain connects the N- and C-HEAT domains.
Pfam PF08439: Oligopeptidase F (family)
This domain is found to the N-terminus of the [pfam:PF01432] domain in bacterial and archaeal proteins including Oligoendopeptidase F.  An example of this protein is Lactococcus lactis PepF.
Pfam PF24541: PDIA6-like, C-terminal thioredoxin-like domain (domain)
This is the C-terminal thioredoxin domain found in human Protein disulfide-isomerase A6 (PDIA6) and similar eukaryotic proteins. PDIA6 may function as a chaperone that inhibits aggregation of misfolded proteins. It also plays a role in platelet aggregation and activation by agonists such as convulxin, collagen and thrombin.
Pfam PF24949: Domain of unknown function (DUF7760) (domain)
This domain is found in uncharacterised proteins mainly from flagellate Discoba. It is predicted to  adopt a globular structure consisting of array  of helices.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF05354: Phage Head-Tail Attachment protein (domain)
This entry includes the phage lambda head-tail attachment protein FII that is required for the joining of phage heads and tails at the last step of morphogenesis. Plays a role in virion assembly by joining the head and the tail at the last step of morphogenesis. Six FII proteins probably bind protein W that closes the DNA-filled capsid, as well as the U tail terminator protein of the pre-assembled tail.
Pfam PF03649: Uncharacterised protein family (UPF0014) (family)
Characterised proteins in this family include probable iron export permease protein FetB, which is part of the ABC transporter complex FetAB, probably involved in iron export, and aluminium sensitive 3 protein, also part of an ABC transporter required for aluminum (Al) resistance. This family also includes integral membrane proteins currently uncharacterised.
Pfam PF08695: Cytochrome oxidase complex assembly protein 1 (family)
Coa1 is an inner mitochondrial membrane protein that associates with Shy1 and is required for cytochrome oxidase complex IV assembly. It contains a conserved hydrophobic segment (amino acids 74-92) with the potential to form a membrane-spanning helix. The N-terminus of Coa1 is rich in positively charged amino acids and could form an amphipathic alpha helix, characteristic of a mitochondrial presequence. A cleavage site for the mitochondrial processing peptidase is predicted adjacent to the presequence. Upon in vitro import into mitochondria, Coa1 is processed to a mature form, indicating that it possesses a cleavable presequence. The eukaryotic cytochrome oxidase complex consists of 12-13 subunits, with three mitochondrial encoded subunits, Cox1-Cox3, forming the core enzyme. Translation of the Cox1 transcript requires the two promoters, Pet309 and Mss51, and the latter has an additional role in translational elongation. Coa1 is necessary for linking the activity of Mss51 to Cox1 insertion into the assembly complex.
Wikipedia: The enzyme cytochrome c oxidase or Complex IV is a large transmembrane protein complex found in bacteria, archaea, and the mitochondria of eukaryotes.
Pfam PF13211: Protein of unknown function (DUF4019) (family)
This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 130 and 183 amino acids in length. There is a single completely conserved residue E that may be functionally important.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF04014: Antidote-toxin recognition MazE, bacterial antitoxin (domain)
AbrB-like is a family of small proteins that operate in conjunction with a cognate toxin molecule. The commonly attributed role of toxin-antitoxin systems is to maintain low-copy number plasmids from one generation to the next. Such gene-pairs are also found on chromosomes and to be associated with a number of biological functions such as: reduction of protein synthesis, gene regulation and retardation of cell growth under nutritional stress. This family includes proteins from a number of different pairings, eg MazE, AbrB, VapB, PhoU, PemI-like and SpoVT.  MazE is the antidote to the toxin MazF of E. coli.  MazE-MazF in E. coli is a regulated prokaryotic chromosomal addiction module. MazE antidote is degraded by the ClpPA protease of the bacterial proteasome. MazE-MazF is thought to play a role in programmed cell death when cells suffer nutrient deprivation, and MazE-MazF modules have also been implicated in the bacteriostatic effects of other addiction modules.
Wikipedia: A toxin-antitoxin system consists of a "toxin" and a corresponding "antitoxin", usually encoded by closely linked genes. The toxin is usually a protein while the antitoxin can be a protein or an RNA. Toxin-antitoxin systems are widely distributed in prokaryotes, and organisms often have them in multiple copies. When these systems are contained on plasmids – transferable genetic elements – they ensure that only the daughter cells that inherit the plasmid survive after cell division. If the plasmid is absent in a daughter cell, the unstable antitoxin is degraded and the stable toxic protein kills the new cell; this is known as 'post-segregational killing' (PSK).
Pfam PF11984: Protein of unknown function (DUF3485) (family)
This family of proteins is functionally uncharacterised. This protein is found in bacteria. Proteins in this family are typically between 223 to 526 amino acids in length. This protein is found associated with [pfam:PF09721].
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF20285: C-terminal domain 9 of the ABC-three component (ABC-3C) systems (domain)
C-terminal domains (CTDs) of ABC-3C systems, contain distinct patterns of charged and polar residues and are not yet unifiable with known domains. These domains are found at the C-terminus of the effector component of the systems, which are upstream of the Middle Component and ABC ATPase components on the genome. Due to the typically large size of these CTDs relative to the actual effector and MC domains, the CTDs are predicted to serves as the platform on which the remaining two components assemble. Therewith, conformational changes transmitted by the ABC ATPase-mediated detection of invasive elements like DNA viruses would result in an unfurling and activation of the CTD-associated effector.
Pfam PF03734: L,D-transpeptidase catalytic domain (domain)
This family of proteins are found in a range of bacteria. It has been shown that this domain can act as an L,D-transpeptidase that gives rise to an alternative pathway for peptidoglycan cross-linking.  This gives bacteria resistance to beta-lactam antibiotics that inhibit PBPs which usually carry out the cross-linking reaction.  The conserved region contains a conserved histidine and cysteine, with the cysteine thought to be an active site residue.  Several members of this family contain peptidoglycan binding domains.  The molecular structure of YkuD protein shows this domain has a novel tertiary fold consisting of a beta-sandwich with two mixed sheets, one containing five strands and the other, six strands. The two beta-sheets form a cradle capped by an alpha-helix. This family was formerly called the ErfK/YbiS/YcfS/YnhG family, but is now named after the first protein of known structure.
Pfam PF06917: Periplasmic pectate lyase (repeat)
This family consists of several Enterobacterial periplasmic pectate lyase proteins ([ec:4.2.2.2]). A major virulence determinant of the plant-pathogenic enterobacterium Erwinia chrysanthemi is the production of pectate lyase enzymes that degrade plant cell walls.
Pfam PF06979: TMEM70/TMEM186/TMEM223 protein family (family)
This entry represents the TMEM70/TMEM186/TMEM223 protein family. TMEM70 is a family of proteins essential for assembly of the mitochondrial proton-transporting ATP synthase complex within the inner mitochondrial membrane. TMEM70 functions in the assembly of complexes I and V.
Pfam PF11588: Protein of unknown function (DUF3243) (family)
This family of proteins with unknown function appears to be restricted to Firmicutes.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF10410: DnaB-helicase binding domain of primase (domain)
This domain is the C-terminal region three-helical domain of primase. Primases synthesise short RNA strands on single-stranded DNA templates, thereby generating the hybrid duplexes required for the initiation of synthesis by DNA polymerases.  Primases are recruited to single-stranded DNA by helicases, and this domain is the region of the primase which binds DnaB-helicase. It is associated with the Toprim domain ([pfam:PF01751]) which is the central catalytic core.
Pfam PF18827: Large polyvalent protein-associated domain 14 (domain)
This is an alpha-helical domain with a conserved glutamate residue that is mainly found in polyvalent proteins of prophages.
Pfam PF20535: Family of unknown function (DUF6750) (family)
This family of proteins is functionally uncharacterised. This family of proteins is found in proteobacteria. Proteins in this family are approximately 130 amino acids in length.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF21852: Family of unknown function (DUF6911) (domain)
This entry represents a family of uncharacterised proteins. Proteins in this family are primarily found in Proteobacteria. The structure of these proteins contains a six stranded beta sheet.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF18143: HAD domain in Swiss Army Knife RNA repair proteins (family)
Family of HAD domain phophoesterases observed in large eukaryotic proteins with predicted role in RNA repair, the so-called 'Swiss Army Knife' repair proteins. May be involved in phosphate group removal during RNA re-ligation.
Pfam PF18691: Cell division control protein 13, OB2 domain (domain)
Cdc13 is an essential yeast protein required for telomere length regulation and genome stability. Cdc13, like a number of single-stranded telomere binding proteins, consists of several oligonucleotide-oligosaccharide binding (OB) folds. These folds potentially arise from evolutionary gene duplication and are involved in multiple functions, including nucleic acid and protein binding and Cdc13 dimerization. This entry represents the OB2 domain, second OB-fold counting from the N terminus of Cdc13. Biochemical assays indicate OB2 is not involved in telomeric DNA or Stn1 binding.  However, disruption of the OB2 dimer in full-length Cdc13 affects Cdc13-Stn1 association, leading to telomere length deregulation, increased temperature sensitivity, and Stn1 binding defects. Hence it is suggested that the dimerization of the OB2 domain of Cdc13 is required for proper Cdc13, Stn1, Ten1 (CST) assembly and productive telomere capping.
Pfam PF24447: Type II restriction enzyme BanI (family)
This entry represents the P subtype restriction enzyme BanI that recognizes the double-stranded sequence 5'-GGYRCC-3' and cleaves after G-1.
Pfam PF03813: Nrap protein domain 1 (domain)
Members of this family are nucleolar RNA-associated proteins (Nrap) which are highly conserved from yeast (Saccharomyces cerevisiae) to human. In the mouse, Nrap is ubiquitously expressed and is specifically localised in the nucleolus. Nrap is a large nucleolar protein (of more than 1000 amino acids). Nrap appears to be associated with ribosome biogenesis by interacting with pre-rRNA primary transcript. This domain has a nucleotidyltransferase structure.
Pfam PF12095: Protein CHLORORESPIRATORY REDUCTION 7 (family)
This entry includes protein from blue-green algae and  plants, including CRR7 protein from Arabidopsis. CRR7 is part of the chloroplastic NAD(P)H dehydrogenase  complex (NDH Complex) involved in respiration,  photosystem I (PSI) cyclic electron transport and CO2  uptake.
Pfam PF15135: Uncharacterised protein UPF0515 (family)
This family of proteins is functionally uncharacterised. This family of proteins is found in eukaryotes.  There are two conserved sequence motifs: PLT and HSC.
Pfam PF06395: CDC24 Calponin (domain)
Is a calponin homology domain.
Pfam PF02895: Signal transducing histidine kinase, homodimeric domain (domain)
This helical bundle domain is the homodimer interface of the signal transducing histidine kinase family.
Wikipedia: In molecular biology, a two-component regulatory system serves as a basic stimulus-response coupling mechanism to allow organisms to sense and respond to changes in many different environmental conditions. Two-component systems typically consist of a membrane-bound histidine kinase that senses a specific environmental stimulus, and a corresponding response regulator that mediates the cellular response, mostly through differential expression of target genes. Although two-component signaling systems are found in all domains of life, they are most common by far in bacteria, particularly in Gram-negative and cyanobacteria; both histidine kinases and response regulators are among the largest gene families in bacteria. They are much less common in archaea and eukaryotes; although they do appear in yeasts, filamentous fungi, and slime molds, and are common in plants, two-component systems have been described as "conspicuously absent" from animals.
Pfam PF24225: Domain of unknown function (DUF7441) (domain)
This entry represents a conserved domain found predominantly in bacteriophage proteins. The domain is characterized by a highly conserved YDRH motif, which likely plays an important role in the domain's function or structure. This family includes proteins from various phages that infect cyanobacteria, particularly Synechococcus and Prochlorococcus species. The proteins contain a central small domain composed of a three stranded beta sheet with an alpha helix inserted between the second and third strands.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF15070: Putative golgin subfamily A member 2-like protein 5 (coiled_coil)
The function of the GOLGA2L5 protein family remains unknown. This family of proteins is thought to be found in the Golgi apparatus of eukaryotes.
Pfam PF05158: RNA polymerase Rpc34 subunit (family)
Subunit specific to RNA Pol III, the tRNA specific polymerase. The C34 subunit of yeast RNA Pol III is part of a subcomplex of three subunits which have no counterpart in the other two nuclear RNA polymerases. This subunit interacts with TFIIIB70 and is  therefore participates in Pol III recruitment.
Pfam PF21919: Phage P23-45 portal protein (family)
This entry represents the homologues of Thermus phage P23-45 portal protein. The portal protein is a key component of many double-stranded DNA viruses, governing capsid assembly and genome packaging. Twelve subunits of the portal protein define a tunnel, through which DNA is translocated into the capsid.
Pfam PF23695: YncO (family)
This protein family includes Protein YncO from Escherichia coli, a 61-residue long sequence predicted to adopt an alpha -helical configuration.
Pfam PF10461: Peptidase S68 (family)
This family of serine peptidases contains PIDD proteins.  PIDD forms a complex with RAIDD and procaspase-2 that is known as the 'PIDDosome'.  The PIDDosome forms when DNA damage occurs and either activates NF-kappaB, leading to cell survival, or caspase-2, which leads to apoptosis.
Pfam PF14776: Cation-channel complex subunit UNC-79 (family)
This family is a component of a cation-channel complex.
Pfam PF03284: Phenazine biosynthesis protein A/B (domain)
The phenazine biosynthesis proteins A and B are involved in the biosynthesis of this antibiotic. Phenazine is a nitrogen-containing heterocyclic molecule with important implications in virulence, competition and biological control .
Pfam PF18074: Primosomal protein N C-terminal domain (domain)
This is the C-terminal domain found in PriA DNA helicase, a multifunctional enzyme that mediates the process of restarting prematurely terminated DNA replication reactions in bacteria. The C-terminal domain (CTD) bears similarity to the S10 subunit which binds branched rRNA within the bacterial ribosome. The C-terminal domain is part of the helicase domain of PriA proteins. It acts together with the 3' DNA-binding domain to form a site for binding ssDNA-binding protein (SSB).
Pfam PF23534: Apicomplexa microprotein (family)
This protein family includes uncharacterised microproteins encoded by small open reading frames (smORFs) from apicomplexa, including [swissprot:A7AUY1] from the parasite Babesia bovis.
Pfam PF22842: Pel9A-like, right handed beta helix region (repeat)
This region is found in Pectate lyase L from Erwinia chrysanthemi (Pel9A) and similar bacterial and fungal proteins. Pel9A shows endo-cleaving activity on polygalacturonate or partially methylated pectin and has an important role in soft -rot disease. This region forms a parallel beta helix domain.
Pfam PF18012: PH domain (domain)
This entry represents the C-terminal part of the split PH domain from syntrophin proteins.
Wikipedia: Pleckstrin homology domain or (PHIP) is a protein domain of approximately 120 amino acids that occurs in a wide range of proteins involved in intracellular signaling or as constituents of the cytoskeleton.