SII-SWORD/CoKE huggingface dataset:
Pfam PF13398: Peptidase M50B-like (family)
This is a family of bacterial and plant peptidases in the same family as MEROPS:M50B.
Pfam PF13733: N-terminal region of glycosyl transferase group 7 (domain)
This is the N-terminal half of a family of galactosyltransferases from a wide range of Metazoa with three related galactosyltransferases activities, all three of which are possessed by one sequence in some cases.  [ec:2.4.1.90], N-acetyllactosamine synthase; [ec:2.4.1.38], Beta-N-acetylglucosaminyl-glycopeptide beta-1,4- galactosyltransferase; and [ec:2.4.1.22] Lactose synthase. Note that N-acetyllactosamine synthase is a component of Lactose synthase along with alpha-lactalbumin, in the absence of alpha-lactalbumin [ec:2.4.1.90] is the catalysed reaction.
Pfam PF02496: ABA/WDS induced protein (family)
This is a family of plant proteins induced by water deficit stress (WDS), or abscisic acid (ABA) stress and ripening.
Pfam PF16981: chi-Conotoxin or t superfamily (domain)
Chi-conotoxin is a family of Cone snail venom chi-conopeptide class bioactive peptides based.  These conopeptides show a unique ability, highly selectively and non-competitively, to inhibit the noradrenaline transporter. They show an unusual cysteine-stabilised scaffold that presents a gamma-turn in an optimised conformation for high affinity interactions with the noradrenaline transporter.
Pfam PF21769: Virion DNA-directed RNA polymerase domain (domain)
This domain is found in Virion DNA-directed RNA polymerase from Bacteriophage N4 (vRNAP), responsible for the transcription of the early region of the double-stranded linear DNA genome of the lytic coliphage. This domain adopts a mostly alpha-helical configuration.
Pfam PF01407: Geminivirus AL3 protein (family)
Geminiviruses are small, ssDNA-containing plant viruses. Geminiviruses contain three ORFs (designated AL1, AL2, and AL3) that overlap and are specified by multiple polycistronic mRNAs. The AL3 protein comprises approximately 0.05% of the cellular proteins and is present in the soluble and organelle fractions. AL3 may form oligomers. Immunoprecipitation of AL3 in a baculovirus expression system extracts expressing both AL1 [pfam:PF00799] and AL3 showed that the two proteins also complex with each other. The AL3 protein is involved in viral replication.
Pfam PF03069: Acetamidase/Formamidase family (family)
This family includes amidohydrolases of formamide [ec:3.5.1.49] and acetamide. [swissprot:Q50228] forms a homotrimer suggesting all the members of this family also do.
Pfam PF01269: Fibrillarin (domain)
Fibrillarin (rRNA 2'-O-methyltransferase fibrillarin) is a component of a nucleolar small nuclear ribonucleoprotein (SnRNP) . It is a S-adenosyl-L-methionine-dependent methyltransferase that has the ability to methylate both RNAs and proteins. Site specificity is provided by a guide RNA that base pairs with the substrate and methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA . Fibrillarin is associated with U3, U8 and U13 small nuclear RNAs in mammals  and is similar to the yeast NOP1 protein . It has a well conserved sequence of around 320 amino acids, and contains 3 domains, an N-terminal Gly/Arg-rich region; a central domain resembling other RNA-binding proteins and containing an RNP-2-like consensus sequence; and a C-terminal Î±-helical domain. An evolutionarily related pre-rRNA processing protein, which lacks the Gly/Arg-rich domain, has been found in various archaebacteria.
Wikipedia: rRNA 2'-O-methyltransferase fibrillarin is an enzyme that in humans is encoded by the FBL gene.
Pfam PF24074: Domain of unknown function (DUF7366) (domain)
This entry represents a small uncharacterised domain from Staphylococcus phage. The domain is predicted to be largely composed of small alpha helices.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF13186: Iron-sulfur cluster-binding domain (domain)
This domain occurs as an additional C-terminal iron-sulfur cluster binding domain in many radical SAM domain, [pfam:PF04055] proteins. The domain occurs in a number of proteins that modify a protein to become an active enzyme, or a peptide to become a ribosomal natural product. The domain is named SPASM because it occurs in the maturases of Subilitosin, PQQ, Anaerobic Sulfatases, and Mycofactocin.
Pfam PF17173: Domain of unknown function (DUF5129) (family)
DUF5129 is domain of unknown function found in uncharacterized proteins from Actinobacteria.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF20371: Family of unknown function (DUF6666) (family)
This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 357 and 490 amino acids in length.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF06837: Fijivirus P9-2 protein (family)
This family consists of several Fijivirus specific P9-2 proteins from Rice black streaked dwarf virus (RBSDV) and Fiji disease virus. The function of this family is unknown.
Pfam PF15626: single CXXC unit (family)
This is a solo version of the zf-CXXC domain with a conserved CXXCXXCX(n)C, zinc-binding motif. This is, thus far,  only detected  in the plant lineage in diverse chromatin proteins.  Structural  comparisons show that the mono-CXXC is homologous to the structural- zinc binding domain of medium chain dehydrogenases. The regular  zf-CXXC domain binds nonmethyl-CpG dinucleotides.
Pfam PF04784: Protein of unknown function, DUF547 (family)
Family of uncharacterised proteins from C. elegans and A. thaliana.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF02861: Clp amino terminal domain, pathogenicity island component (family)
This short domain is found in one or two copies at the amino terminus of ClpA and ClpB proteins from bacteria and eukaryotes. The function of these domains is uncertain but they may form a protein binding site. In many bacterial species, including E.coli, this region represents the N-terminus of one of the key components of the pathogenicity island complex that injects toxin from one bacterium into another.
Wikipedia: Endopeptidase Clp (EC 3.4.21.92, endopeptidase Ti, caseinolytic protease, protease Ti, ATP-dependent Clp protease, ClpP, Clp protease). This enzyme catalyses the following chemical reactionHydrolysis of proteins to small peptides in the presence of ATP and Mg2+.
Pfam PF02996: Prefoldin subunit (coiled_coil)
This family comprises of several prefoldin subunits. The biogenesis of the cytoskeletal proteins actin and tubulin involves interaction of nascent chains of each of the two proteins with the oligomeric protein prefoldin (PFD) and their subsequent transfer to the cytosolic chaperonin CCT (chaperonin containing TCP-1). Electron microscopy shows that eukaryotic PFD, which has a similar structure to its archaeal counterpart, interacts with unfolded actin along the tips of its projecting arms. In its PFD-bound state, actin seems to acquire a conformation similar to that adopted when it is bound to CCT.
Pfam PF11744: Aluminium activated malate transporter (family)
This entry represents an malate transporter which has been is identified as being critical for aluminium tolerance in Arabidopsis thaliana . Some family members have been reported to permeable to chloride, nitrate, sulphate and malate .
Pfam PF24659: Domain of unknown function (DUF7648) (domain)
This domain is found in uncharacterised proteins mainly from plants. It is predicted to adopt a globular structure consisting of array of helices.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF07801: Protein of unknown function (DUF1647) (family)
The sequences making up this family are all derived from hypothetical proteins expressed by C. elegans. The region in question is approximately 160 amino acids long. The GO annotation for this protein indicates the protein to be involved in nematode larval development and to have a positive regulation on growth rate.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF16506: Putative virion glycoprotein of insect viruses (family)
This entry corresponds to putative glycoproteins from chroparaviruses. It carries two putative disulfide bridges. No similarity can be found with any other glycoproteins outside this region.
Pfam PF20387: Family of unknown function (DUF6682) (family)
This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and viruses. Proteins in this family are typically between 216 and 235 amino acids in length.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF12400: STIMATE family (family)
STIMATE is a ER-resident multi-transmembrane protein that serves as a positive regulator of Ca(2+) influx in vertebrates. It interacts with ER-resident Ca2+ sensor protein STIM1 to promote STIM1 conformational switch. This entry also includes  budding yeast YPL162C.
Pfam PF05552: Mechanosensitive ion channel, conserved TM helix (family)
This alignment represents a conserved transmembrane helix, often found in small conductance mechanosensitive channels (MscS) in association with [pfam:PF00924], such as [swissprot:Q57634] and [swissprot:Q58543] MscS assembles to a homoheptameric complex; each monomer consists of a N-terminal transmembrane region and a large cytoplasmic segment composed of a five-stranded antiparallel beta-sheet (middle/second) domain ([pfam:PF00924]) and a C-terminal alpha/beta-domain ([pfam:PF21082]). The N-terminal region consists of three membrane spanning helices (TM1, TM2 and TM3), TM1 is represented in this entry. In the heptamer, the permeation pathway is formed by the packing of TM3s, flanked by TM1-TM2 helical hairpins.
Pfam PF11407: Type II restriction enzyme MunI (family)
Type II restriction enzyme MunI recognises the palindromic sequence C/AATTG. It makes contact with the DNA via the major groove.
Pfam PF10880: Protein of unknown function (DUF2673) (family)
This family of proteins with unknown function appears to be restricted to Rickettsiae spp.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF08681: Protein of unknown function (DUF1778) (domain)
This is a family of uncharacterised proteins.  The structure of one of the hypothetical proteins in this family has been solved and it forms a helix structure which may form interactions with DNA.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF02444: Hepatitis E virus ORF-2 (Putative capsid protein) (family)
The Hepatitis E virus (HEV) genome is a single-stranded, positive-sense RNA molecule of approximately 7.5 kb. Three open reading frames (ORF) were identified within the HEV genome: ORF1 encodes non-structural proteins, ORF2 encodes the putative structural protein(s), and ORF3 encodes a protein of unknown function. ORF2 contains a consensus signal peptide sequence at its amino terminus and a capsid-like region with a high content of basic amino acids similar to that seen with other virus capsid proteins.
Pfam PF11105: Arthropod cardioacceleratory peptide 2a (family)
CCAP exerts a reversible and dose-dependant cardio-stimulatory effect on the semi-isolated heart of experimental beetles. CCAP also increases free hemolymph sugar concentration in young larvae and adults of the meal-worm beetle.
Pfam PF01935: Helicase HerA, central domain (domain)
This entry represents the central domain found in archaeal proteins such as DNA double-strand break repair helicase HerA ([ec:3.6.4.12]). HerA is a helicase which is able to utilise either 3' or 5' single-stranded DNA extensions for loading and subsequent DNA duplex unwinding. It forms a complex with NurA nuclease, this complex has the 5'-3' DNA end resection activity and is essential for cell viability in the crenarchaeon Sulfolobus islandicus. This domain includes the the central RecA-like catalytic core and a flanking four-helix bundle. The function of this prokaryotic domain is unknown. It contains several conserved aspartates and histidines that could be metal ligands.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF06124: Staphylococcal protein of unknown function (DUF960) (domain)
This family consists of several hypothetical proteins from several species of Staphylococcus. The function of this family is unknown.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF10962: Protein of unknown function (DUF2764) (family)
This bacterial family of proteins has no known function.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF09911: Uncharacterized protein conserved in bacteria (DUF2140) (family)
This domain, found in various hypothetical prokaryotic proteins, has no known function.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF00770: Adenovirus endoprotease (domain)
This family of adenovirus thiol endoproteases specifically cleave Gly-Ala peptides in viral precursor peptides.
Pfam PF24804: Domain of unknown function (DUF7705) (domain)
This domain is found in a group of uncharacterised plant proteins. It has remote similarity to some glucanases and it is predicted to adopt similar beta-sandwich structure but elaborated with additional strands.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF14830: Haemocyanin beta-sandwich (family)
This antiparallel beta sandwich domain occurs in mollusc haemocyanins. Each mollusc haemocyanin contains several globular oxygen binding functional units. Each unit consists of an alpha-helical copper binding domain ([pfam:PF00264]) and an antiparallel beta sandwich domain.
Pfam PF21055: ZSWIM4-8, C-terminal (repeat)
This entry represents an alpha-solenoid structure found at the C-terminal of Zinc finger ZSWIM domain-containing proteins 4-8 (ZSWIM4-8). ZSWIM8 is a substrate recognition component of a SCF-like E3 ubiquitin-protein ligase complex that promotes target-directed microRNA degradation (TDMD), a process that mediates degradation of microRNAs (miRNAs). ZSWIM4 has been associated with JAK2 inhibition resistance in breast cancer. ZSWIM5 was reported to suppress the invasion and migration of lung cancer cells by regulating the expression of cyclins and MMPs and may constitute a target for the diagnosis and therapy of non-small cell lung cancer (NSCLC). ZSWIM6 plays a key role in neuronal development and  mutations in this protein causes acromelic frontonasal dysostosis (AFND), an autosomal-dominant severe frontonasal and limb malformation syndrome. In ZSWIM6, this is termed the Sin3-like domain, in which a recurrent de novo missense variant causes AFND.
Pfam PF05060: N-acetylglucosaminyltransferase II (MGAT2) (family)
UDP-N-acetyl-D-glucosamine:alpha-6-D-mannoside beta-1,2-N- acetylglucosaminyltransferase II (EC 2.4.1.143) (GnT II/MGAT2) is a Golgi resident enzyme that catalyses an essential step in the biosynthetic pathway leading from high mannose to complex N-linked oligosaccharides. Mutations in the MGAT2 gene lead to congenital disorder of glycosylation (CDG IIa). CDG IIa patients have an increased bleeding tendency,  unrelated to coagulation factors.
Pfam PF19032: Intu longin-like domain 2 (domain)
This entry represents a longin-like domain found in Intu and related proteins.
Pfam PF07488: Glycosyl hydrolase family 67 middle domain (domain)
Alpha-glucuronidases, components of an ensemble of enzymes central to the recycling of photosynthetic biomass, remove the alpha-1,2 linked 4-O-methyl glucuronic acid from xylans.  This family represents the central catalytic domain of alpha-glucuronidase.
Wikipedia: In molecular biology, glycoside hydrolase family 67 is a family of glycoside hydrolases.
Pfam PF03239: Iron permease FTR1 family (family)
Fungi uptake extracellular ferrous iron (Fe2+) using a bipartite high-affinity transporter consisting of a multicopper ferroxidase associated with a membrane permease which translocates generated ferric iron (Fe3+) into the cytosol. The Saccharomyces cerevisiae (Baker's yeast) iron permease FTR1 is a plasma membrane permease for high-affinity iron uptake . FTR1, together with multicopper oxidase FET3, mediate high-affinity iron uptake. Schizosaccharomyces pombe Fio1 (ferrous iron oxidase) and Fip1 (ferriferous permease), share significant similarity to FET3 and FTR1 from S. cerevisiae . In Neosartorya fumigata, the high affinity iron permease is known as FtrA .

Many bacteria possess Fe2+ transporters with functional similarities to the FET3-FTR1 system. Escherichia coli encodes an EfeUOB transporter where EfeU is homologous to the high-affinity iron permease FTR1 of Saccharomyces cerevisiae . Bacillus subtilis encodes similar proteins, but not identical to the E. coli EfeUOB transporter components. B. subtilis EfeUOB uses a transport system that permits the high-affinity acquisition of both Fe2+ and Fe3+ .

This entry also includes the vacuolar iron transporter FTH1 .
Pfam PF10013: Uncharacterized protein conserved in bacteria (DUF2256) (domain)
Members of this family of hypothetical bacterial proteins have no known function.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF10050: Predicted metal-binding protein (DUF2284) (family)
Members of this family of metal-binding hypothetical bacterial proteins have no known function.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF19079: Collagen-flanked surface repeat (repeat)
Repeat flanked by collagen-like CXX motifs found in bacterial cell surface proteins.
Pfam PF24901: DNA replication licensing factor MCM7, winged helix (domain)
This domain is found at the C-terminal end of human DNA replication licensing factor MCM7, a component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. This domain is predicted to adopt a winged helix configuration.