SII-SWORD/CoKE huggingface dataset:
Pfam PF16812: C-terminal head domain of the fowl adenovirus type 1 long fibre (domain)
AdHead_fibreRBD is a C-terminal part of the head domain of the dsDNA viruses, no RNA stage, Adenovirus. This is a globular head domain with an anti-parallel beta-sandwich fold formed by two four-stranded beta-sheets with the same overall topology as human adenovirus fibre heads. This C-terminal domain is the receptor-binding domain of the avian adenovirus long fibre.
Pfam PF21868: GlcNAc-binding protein A, third domain (domain)
This domain is found in GlcNAc-binding protein A from Vibrio cholerae (GbpA), which is thought to promote attachment to both epithelial cell surfaces and marine chitin. GbpA shows four domains. This entry represents the third domain D3, which bind to the surface of the bacteria. It shows distant structural similarity to bacterial surface proteins, adopting an immunoglobulin fold.
Pfam PF21516: YqeH-like, C-terminal (domain)
This entry is found at the C-terminal of Nitric oxide-associated protein 1 (NOA1) from animals and rice, BPG2 from Arabidopsis and YqeH from B. subtilis. YqeH is an orthologue of NOA1. This domain has a beta-sandwich structure with homology to the RNA-binding regulator TRAP, and the hypoxia factor pVHL. The residues for RNA recognition in TRAP are conserved in members of this entry, suggesting that these are G-proteins that may regulate nucleic acid recognition.
Pfam PF15094: Domain of unknown function (DUF4556), Ig-like (domain)
This entry represents a immunoglobulin-like domain found in a functionally uncharacterised protein family. This family of proteins is found in vertebrates and includes human protein C1orf127.
Wikipedia: Uncharactarized protein C1orf127 is a protein that in humans is encoded by the C1orf127 gene, the structure and function of which is poorly understood by the scientific community. C1orf127 is targeted for extracellular secretion in humans.
Pfam PF06963: Ferroportin1 (FPN1) (family)
This family represents a conserved region approximately 100 residues long within eukaryotic Ferroportin1 (FPN1), a protein that may play a role in iron export from the cell. This family may represent a number of transmembrane regions in Ferroportin1.
Pfam PF22798: DUF5817, C-terminal domain (domain)
This entry represents a helix-turn-helix (HTH) domain found in a group of functionally uncharacterized prokaryotic proteins, typically associated with the Domain of Unknown Function (DUF5817) (Pfam: PF19134).
Pfam PF10959: Protein of unknown function (DUF2761) (family)
Members in this family of proteins are annotated as KleF however no function is known.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF13478: XdhC Rossmann domain (domain)
This entry is the rossmann domain found in the Xanthine dehydrogenase accessory protein.
Pfam PF08584: Ribonuclease P 40kDa (Rpp40) subunit (family)
The tRNA processing enzyme ribonuclease P (RNase P) consists of an RNA molecule and at least eight protein subunits. Subunits hpop1, Rpp21, Rpp29, Rpp30, Rpp38, and Rpp40 (this entry) are involved in extensive, but weak, protein-protein interactions in the holoenzyme complex.
Pfam PF09012: FeoC like transcriptional regulator (domain)
This family contains several transcriptional regulators, including FeoC, which contain a HTH motif.  FeoC acts as a [Fe-S] dependant transcriptional repressor.
Pfam PF03326: Herpesvirus transcription activation factor (transactivator) (family)
This family includes EBV BRLF1 and similar ORF 50 proteins from other herpesviruses.
Pfam PF19768: Family of unknown function (DUF6255) (family)
This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0001662) is described by MIBiG as an example of the following biosynthetic class, polyketide. It includes a member from the mediomycin A biosynthetic gene cluster from Kitasatospora  mediocidica.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF15931: Domain of unknown function (DUF4747) (family)
This family of proteins is found in bacteria. Proteins in this family are typically between 263 and 305 amino acids in length.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF11372: Domain of unknown function (DUF3173) (domain)
This family of proteins with unknown function appears to be restricted to Firmicutes. These proteins appear to be distantly related to HHH domains and are therefore likely to be DNA-binding. Genomic environment-visualisation confirms the likely function as being DNA-binding, as this short protein lies very closely between an integrase and a replication protein (http://www.microbesonline.org/).
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF19332: E3 ubiquitin-protein ligase RNF180 C-terminus (family)
This family represents the C-terminal region of the E3 ubiquitin-protein ligase RNF180 (Also known as Rines: RING finger protein in neural stem cells) which comprises its transmembrane domain. This is an integral membrane protein located mainly on the cytoplasmic side of the endoplasmic reticulum and functions as an E3 ubiquitin ligase. It is thought that it is involved in modulation of neuronal function, such as regulation of synaptic structure and synaptic plasticity due to its high expression in mature brain.
Pfam PF04816: tRNA (adenine(22)-N(1))-methyltransferase (family)
tRNA_MT is a family of bacterial tRNA (adenine(22)-N(1))-methyltransferase enzymes with a Rossmann-like fold. This enzyme carries out the function of N1-adenosine methylation at position 22 of bacterial tRNA.
Pfam PF08032: RNA 2'-O ribose methyltransferase substrate binding (domain)
This domain is a RNA 2'-O ribose methyltransferase substrate binding domain.
Pfam PF12028: Protein of unknown function (DUF3515) (family)
This family of proteins is functionally uncharacterised. This protein is found in bacteria. Proteins in this family are typically between 166 to 214 amino acids in length. This protein has a conserved RCG sequence motif.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF19093: Family of unknown function (DUF5781) (family)
Family of unknown function predominantly found in Halobacteria.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF20490: Secretoglobin 3A (family)
This family includes secretoglobin family 3A member 1 (SCGB3A1) and member 2 (SCGB3A2), also known as uteroglobin-related proteins. They are a small secreted proteins expressed in airway epithelial cells. SCGB3A2, also known as UGRP1, has an important anti-inflammatory activity and is involved in asthma. SCGB3A2 mediates its anti-inflammatory action through inhibition of ERK and JNK activation. It is also involved in lung development and has anti-fibrotic activity in lung.
Pfam PF18142: SMODS and SLOG-associating 2TM effector domain (domain)
The SLATT domain contains two transmembrane helices. SLATT domains are generally predicted to function in bacteria as pore-forming effectors in a class of conflict systems which are reliant on the production of second messenger nucleotide or nucleotide derivatives. SLATT domains are predicted to initiate cell suicide responses upon their activation. The role of this fungal family is not yet understood, although the expansion of the family in many fungal lineages points to a potential role in conflict.
Pfam PF23522: Apicomplexa microprotein (family)
This protein family includes uncharacterised microproteins encoded by small open reading frames (smORFs) from apicomplexa, including [swissprot:A7AU22] from the parasite Babesia bovis.
Pfam PF24385: ATP-dependent RNA helicase DHX29, DSRM-like (domain)
This is a presumed domain found near the middle of ATP-dependent RNA helicase DHX29 from human and at the N-terminal of the putative ATP-dependent RNA helicase YLR419W from yeast, which has been identified as the homologue of the translation initiation factor DHX29 from human. DHX29 is a DExH-box protein involved in eukaryotic translation initiation. DHX29 is required to bind to the 40S subunit of the 43S preinitiation complex to allow highly structured 5'-UTRs to be scanned. This domain is similar to DSRM (Double-Stranded RNA-binding Motif, also known as dsRBD) domains.
Pfam PF18666: Carbohydrate-binding module 64 (domain)
Spirochaeta thermophila secretes seven glycoside hydrolases for plant biomass degradation that carry a carbohydrate-binding module 64 (CBM64) appended at the C-terminus. CBM64 adsorbs to various beta1-4-linked pyranose substrates and shows high affinity for cellulose. Structure analysis indicates a jelly-roll-like fold corresponding to a surface-binding type A CBM.
Wikipedia: In molecular biology, a carbohydrate-binding module (CBM) is a protein domain found in carbohydrate-active enzymes. The majority of these domains have carbohydrate-binding activity. Some of these domains are found on cellulosomal scaffoldin proteins. CBMs were previously known as cellulose-binding domains. CBMs are classified into numerous families, based on amino acid sequence similarity. There are currently 64 families of CBM in the CAZy database.
Pfam PF02754: Cysteine-rich domain (domain)
The key element of this domain is the CX31-38CCX33-34CXXC sequence motif normally found at the C-terminus in archaeal and bacterial Hdr-like proteins. There may be one or two copies, and the motif is probably an iron-sulfur binding cluster. In some instances one of the cysteines is replaced by an aspartate, and aspartate can in principle also function as a ligand of an iron-sulfur cluster. The entry includes a subunit from heterodisulphide reductase and a subunit from glycolate oxidase ([swissprot:P52074]) and glycerol-3-phosphate dehydrogenase.
Pfam PF02618: YceG-like family (family)
This family of proteins is found in bacteria. Proteins in this family are typically between 332 and 389 amino acids in length. This family was previously incorrectly annotated and names as aminodeoxychorismate lyase. The structure of [swissprot:P28306] was solved by X-ray crystallography.
Pfam PF10264: Winged helix Storkhead-box1 domain (family)
This is the conserved N-terminal winged helix domain of Storkhead-box1 protein which is likely to be a DNA binding domain. In humans the full-length protein controls polyploidization of extravillus trophoblast and is implicated in pre-eclampsia.
Pfam PF19606: Family of unknown function (DUF6111) (family)
This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 86 and 106 amino acids in length.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF20956: Domain of unknown function (DUF4931) C-terminal domain (domain)
This family consists of uncharacterized proteins around 270 residues in length and is mainly found in various Bacillus cereus species. Some members of this family are annotated as Galactose-1-phosphate uridylyltransferases, but the specific function of this family is unknown.
Pfam PF12740: PET hydrolase-like (domain)
This family includes Poly(ethylene terephthalate) hydrolase which is involved in the degradation and assimilation of the plastic poly(ethylene terephthalate) (PET).
Pfam PF05072: Herpesvirus UL43 protein (family)
UL43 genes are expressed with true-late (gamma2) kinetics and have been identified as a virion tegument component.
Pfam PF07413: Betaherpesvirus immediate-early glycoprotein UL37 (family)
This family consists of several Betaherpesvirus immediate-early glycoprotein UL37 sequences. The human cytomegalovirus (HCMV) UL37 immediate-early regulatory protein is a type I integral membrane N-glycoprotein which traffics through the ER and the Golgi network.
Pfam PF21009: Suprabasin, GxHH repeat (repeat)
Suprabasin (SBSN) is involved in epidermal differentiation and may play a role in skin barrier formation. It has been proposed to be a component of the cornified envelope, an essential structure for skin protection. Its exact function is not yet clear; it has been associated with multiple diseases such as cancer and autoimmune disorders. It is a secreted molecule that may induce cellular signalling (AKT, WNT/beta-catenin, and/or p38MAPK signalling) and processes (migration, proliferation, neovascularization apoptosis- and immune-resistance). It contains a repeated sequence GxHH, with no other similar sequence in the human proteome, which suggests an evolutionarily unique and conserved role. It has also been described a FG (Phe-Gly) motif, which is common in scaffold proteins (keratin 1/2/10 and fillagrin-2 in addition to SBSN).
Pfam PF14385: Domain of unknown function (DUF4416) (family)
This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 176 and 187 amino acids in length. There is a conserved DPG sequence motif.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF18313: Thiolase-like protein type 1 additional C-terminal domain (domain)
This domain is found in thiolase-like protein type 1 (TLP1) present in Mycobacterium smegmatis. Thiolase enzymes are acetyl-coenzyme A acetyltransferases which convert two units of acetyl-CoA to acetoacetyl CoA in the mevalonate pathway. This domain is deemed an additional C-terminal region, much like the SPC2-thiolase present in mammals which has an additional C-terminal domain termed the sterol carrier protein-2 (SPC2). However, the additional C-terminal domain in TLP1 folds differently to the traditional SCP2-fold observed in mammalian SPC2-thiolase. The topology of the C-terminal domain of TLP1 is reminiscent of single strand nucleic acid binding proteins.
Pfam PF05358: DicB protein (family)
DicB is part of the dic operon, which resides on cryptic prophage Kim. Under normal conditions, expression of dicB is actively repressed. When expression is induced, however, cell division rapidly ceases, and this division block is dependent on MinC with which it interacts.
Pfam PF01126: Heme oxygenase (domain)
Haem oxygenase (1.14.99.3) (HO)  is the microsomal enzyme that, in animals, carries out the oxidation of haem, it cleaves the haem ring at the alpha-methene bridge to form biliverdin and carbon monoxide . Biliverdin is subsequently converted to bilirubin by biliverdin reductase. In mammals there are three isozymes of haem oxygenase: HO-1 to HO-3. The first two isozymes differ in their tissue expression and their inducibility: HO-1 is highly inducible by its substrate haem and by various non-haem substances, while HO-2 is non-inducible. It has been suggested  that HO-2 could be implicated in the production of carbon monoxide in the brain where it is said to act as a neurotransmitter. In the genome of the chloroplast of red algae as well as in cyanobacteria, there is a haem oxygenase (gene pbsA) that is the key enzyme in the synthesis of the chromophoric part of the photosynthetic antennae . A haem oxygenase is also present in the bacteria Corynebacterium diphtheriae (gene hmuO), where it is involved in the acquisition of iron from the host haem . There is, in the central section of these enzymes, a well-conserved region centred on a histidine residue.
Wikipedia: Heme oxygenase, or haem oxygenase, is an enzyme that catalyzes the degradation of heme to produce biliverdin, ferrous iron, and carbon monoxide.
Pfam PF01137: RNA 3'-terminal phosphate cyclase (domain)
RNA cyclases are a family of RNA-modifying enzymes that are conserved in all cellular organisms. They catalyse the ATP-dependent conversion of the 3'-phosphate to the 2',3'-cyclic phosphodiester at the end of  RNA, in a reaction involving formation of the covalent AMP-cyclase  intermediate. The structure of RTC demonstrates that RTCs are  comprised two domain.  The larger domain contains an insert domain of approximately 100 amino acids.
Pfam PF21973: Family of unknown function (DUF6925) (family)
This is a family of uncharacterised bacterial proteins. They are probably distantly related to heme-binding proteins PhuS, ChuS, HmuS.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF13978: Protein of unknown function (DUF4223) (family)
This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 60 amino acids in length. These proteins are likely to be lipoproteins (attachment site currently included in alignment).
Pfam PF07909: Protein of unknown function (DUF1663) (family)
The members of this family are hypothetical proteins expressed by Trypanosoma cruzi, a  eukaryotic parasite that causes Chagas' disease in humans. This region is found as multiple copies per protein.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF23932: Phage termination protein (family)
This entry represents a likely phage terminator protein which terminates the elongation of the phage tail tube. This protein shows structural similarity to the PAM3 terminator protein which forms a hexameric ring. This protein has a beta sandwich domain nested within the terminator like domain.
Pfam PF12806: Acetyl-CoA dehydrogenase C-terminal like (domain)
this domain would appear to be the very C-terminal region of many bacterial acetyl-CoA dehydrogenases.
Pfam PF09432: Tho complex subunit THP2 (family)
The THO complex plays a role in coupling transcription elongation to mRNA export.  It is composed of subunits THP2, HPR1, THO2 and MFT1.
Pfam PF11879: Domain of unknown function (DUF3399) (family)
This domain is functionally uncharacterised. This domain is found in eukaryotes.  This presumed domain is about 100 amino acids in length.  This domain is found associated with [pfam:PF02214], [pfam:PF00520].
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF14721: Apoptosis-inducing factor, mitochondrion-associated, C-term (domain)
This C-terminal domain appears to be a dimerisation domain of the mitochondrial apoptosis-inducing factor 1.  protein. The domain also appears at the C-terminus of FAD-dependent pyridine nucleotide-disulfide oxidoreductases. Apoptosis inducing factor (AIF) is a bifunctional mitochondrial flavoprotein critical for energy metabolism and induction of caspase-independent apoptosis. On reduction with NADH, AIF undergoes dimerisation and forms tight, long-lived FADH2-NAD charge-transfer complexes proposed to be functionally important.
Pfam PF21227: Myb-like DNA-binding domain (domain)
This domain is found in proteins from vertebrates. It shows three alpha-helices, one of them functioning as a recognition helix [1.2].
Pfam PF15269: Zinc-finger (domain)
this is a family of eukaryotic zinc-fingers.
Pfam PF09884: Uncharacterized protein conserved in archaea (DUF2111) (family)
This domain, found in various hypothetical archaeal proteins, has no known function.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF15638: Metallopeptidase toxin 2 (family)
A zincin-like metallopeptidase domain found in bacterial polymorphic toxin systems.
Pfam PF09520: Type II restriction endonuclease, TdeIII (family)
This family includes many TdeIII restriction endonucleases that recognise and cleave at GGNCC sites. TdeIII cleave unmethylated double-stranded DNA.