SII-SWORD/CoKE huggingface dataset:
Pfam PF23736: Zona pellucida sperm-binding protein 2, Ig-like domain (domain)
This domain is found in human Zona pellucida sperm-binding protein 2 (ZP2) and similar proteins from vertebrates. ZP2 is a component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilisation polyspermy. This domain is predicted to adopt a two-layer beta sandwich configuration.
Pfam PF10240: Multivesicular body subunit 12 (family)
MVB12A (also known as CFBP) and MVB12B are subunits of the ESCRT-I complex, which mediates  the sorting of ubiquitinated cargo protein from the  plasma membrane to the endosomal vesicle.  MVB12A plays a key role in the ligand-mediated internalization and down-regulation of the EGF receptor.
Pfam PF02431: Chalcone-flavanone isomerase (domain)
Chalcone-flavanone isomerase is a plant enzyme responsible for the isomerisation of chalcone to naringenin, 4',5,7-trihydroxyflavanone, a key step in the biosynthesis of flavonoids.
Wikipedia: In enzymology, a chalcone isomerase is an enzyme that catalyzes the chemical reactiona chalcone  a flavanone
Pfam PF09182: Bacterial purine repressor, N-terminal (domain)
The N-terminal domain of the bacterial purine repressor PuR is a winged-helix domain, a subdivision of the HTH structural family. It consists of a canonical arrangement of secondary structures: a1-b1-a2-T-a3-b2-W-b3, where a2-T-a3 is the HTH motif, a3 is the recognition helix, and W is the wing. The domain allows for recognition of a conserved CGAA sequence in the centre of a DNA PurBox, resulting in binding to the major groove of DNA.
Pfam PF06951: Group XII secretory phospholipase A2 precursor (PLA2G12) (domain)
This family consists of several group XII secretory phospholipase A2 precursor (PLA2G12) ([ec:3.1.1.4]) proteins. Group XII and group V PLA(2)s are thought to participate in helper T cell immune response through release of immediate second signals and generation of downstream eicosanoids.
Pfam PF21670: NuMA N-terminal hook domain (domain)
Mitotic progression is orchestrated by the microtubule-based motor dynein, which sustains all mitotic spindle functions. During cell division, cytoplasmic dynein acts with the high-molecular-weight complex dynactin and nuclear mitotic apparatus (NuMA) to organize and position the spindle.  NuMA contains a hook domain contacting directly LIC1 and LIC2 chains through a conserved hydrophobic patch shared among other Hook adaptors. Hook adaptor proteins share an N-terminal conserved globular hook domain, which folds as a variant of the helical calponin homology (CH) domain.
Pfam PF05473: UL45 protein, carbohydrate-binding C-type lectin-like (family)
This family consists of several UL45 proteins. The herpes simplex virus UL45 gene encodes an 18 kDa virion envelope protein whose function remains unknown. It has been suggested that the 18 kDa UL45 gene product is required for efficient growth in the central nervous system at low doses and may play an important role under the conditions of a naturally acquired infection. This family also contains several Varicellovirus UL45 or gene 15 proteins. The Equine herpesvirus 1 UL45 protein represents a type II membrane glycoprotein which has been found to be non-essential for EHV-1 growth in vitro but deletion reduces the viruses' replication efficiency. Studies have shown that UL45 has a C-type lectin-like fold, suggesting that it might have a carbohydrate-binding function.
Pfam PF07576: BRCA1-associated protein 2 (family)
These proteins include BRCA1-associated protein 2 (BRAP2), which binds nuclear localisation signals (NLSs) in vitro and in yeast two-hybrid screening. These proteins share a region of sequence similarity at their N terminus.  They also have [pfam:PF02148] at the C terminus.
Pfam PF23896: Domain of unknown function (DUF7244) (domain)
This entry represents an uncharacterized protein found in various bacteriophages that infect bacteria in the family Enterobacteriaceae, including phages of Escherichia, Shigella and Citrobacter. The protein is approximately 55-60 amino acids in length. An AlphaFold model shows this domain adopts a small beta barrel structure. This domain is possibly related to the KOW motif.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF25002: Domain of unknown function (DUF7780) (domain)
This domain is found in uncharacterised plant proteins. It has a detectable similarity to known glycosyltransferases clan GT-A and is predicted to adopt similar structure.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF14705: Costars (domain)
This domain is found both alone and at the C-terminus of actin-binding Rho-activating protein (ABRA). It binds to actin, and in muscle regulates the actin cytoskeleton and cell motility. It has a winged helix-like fold consisting of three alpha-helices and four antiparallel beta strands. Unlike typical winged helix proteins it does not bind to DNA, but contains a hydrophobic groove which may be responsible for interaction with other proteins.
Pfam PF13763: Domain of unknown function (DUF4167) (family)
This presumed domain is functionally uncharacterised.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF18316: S-layer protein SbsC C-terminal domain (domain)
This domain is found in the crystalline bacterial cell-surface layer (S-layer) protein SbsC present in Geobacillus stearothermophilus. S-layers are a common feature of archaeal cell envelopes. SbsC is an oblique lattice forming protein. This domain, termed Domain 9, is located at the C-terminal region of SbsC.  The C-terminal region comprises the self-assembly domain responsible for the formation of the crystalline array.
Pfam PF24800: Domain of unknown function (DUF7702) (domain)
This entry represents a domain found in uncharacterised proteins mainly from fungi. It has a detectable similarity to domains members of Lipid-translocating exporter superfamily and are predicted to adopt similar structure.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF17007: HTH-like (family)
This is a family of microsporidial sequences whose function is not known. It is possible that the proteins are DNA-binding as there is distant homology to helix-turn-helix families at the N-terminus.
Pfam PF02138: Beige/BEACH domain (family)
BEACH (Beige and Chediak-Higashi) domains, implicated in membrane trafficking, are present in a family of proteins conserved throughout eukaryotes. This group contains human lysosomal trafficking regulator (LYST), LPS-responsive and beige-like anchor (LRBA) and neurobeachin. Disruption of LYST leads to Chediak-Higashi syndrome, characterized by severe immunodeficiency, albinism, poor blood coagulation and neurologic problems. Neurobeachin is a candidate gene linked to autism. LBRA seems to be upregulated in several cancer types. It has been shown that the BEACH domain itself is important for the function of these proteins .
The BEACH domain is usually followed by a series of WD repeats.
Pfam PF19429: Evasins Class A (family)
This family represents evasins proteins from ticks, secreted glycoproteins that enhance host blood flow and have anti-inflammatory activity as they bind to chemokines and prevent leukocyte recruitment. Evasins can be divided in two classes based on their chemokine selectivity. Class A binds CC chemokines and includes Evasin-1 (EVA-1) and Evasin-4, being EVA-1 more selective. Class B Evasins include Evasin-3 which binds and inhibits several CXC chemokines but not CC chemokines. This family contains eight conserved Cys residues that define four intramolecular disulfide bonds. The N- and C-terminal regions are flexible, extend from either side of the core and form a concave surface with the first beta-sheet suitable for binding another EVA-1 molecule or to a chemokine. There are two Gly residues strictly conserved. Predicted glycosylation sites were identified on the exterior surface of the structure. These proteins are interesting therapeutic anti-inflammatory agents.
Pfam PF22881: FilE, C-terminal domain (domain)
This entry represents a domain found C-terminal in FilE protein. FilE is found almost exclusively in Acinetobacter, and is assigned as a putative pilus system protein from local genomic contexts that include several additional putative pilus system proteins. It is predicted to adopt a globular structure similar to galactose-binding domains.
Pfam PF03327: Herpesvirus capsid shell protein VP19C (family)
The family includes the triplex capsid protein 1 (TRX1, UL38 or VP19C) from herpesviruses, which is a structural component of the icosahedral capsid. The capsid is composed of pentamers and hexamers of the major capsid protein, which are linked together by heterotrimers called triplexes. These triplexes are formed by a single molecule of TRX1 and two copies of triplex protein 2 (TRX2) . Additionally, TRX1 is required for efficient transport of TRX2 to the nucleus, which is the site of capsid assembly .
Pfam PF08116: PhTx neurotoxin family (family)
This family consists of PhTx insecticidal neurotoxins that are found in the venom of Brazilian, Phoneutria nigriventer. The venom of the Phoneutria nigrivente contains numerous neurotoxic polypeptides of 30-140 amino acids which exert a range of biological effects.  While some of these neurotoxins are lethal to mice after intracerebroventricular injections, others are extremely toxic to insects of the orders Diptera and Dictyoptera but had much weaker toxic effects on mice.
Pfam PF12831: FAD dependent oxidoreductase (family)
This family of proteins contains FAD dependent oxidoreductases and related proteins.
Pfam PF02066: Metallothionein family 11 (family)
Metallothioneins (MT) are small proteins that bind heavy metals, such as zinc, copper, cadmium, nickel, etc. They have a high content of cysteine residues that bind the metal ions through clusters of thiolate bonds . The metallothionein superfamily comprises all polypeptides that resemble equine renal metallothionein in several respects, e.g. low molecular weight; high metal content; amino acid composition with high Cys and low aromatic residue content; unique sequence with characteristic distribution of cysteines, and spectroscopic manifestations indicative of metal thiolate clusters. A MT family subsumes MTs that share particular sequence-specific features and are thought to be evolutionarily related. Fifteen MT families have been characterised, each family being identified by its number and its taxonomic range.

Fungi-IV (family 11) MTs are proteins of about 55-56 residues, with 9 conserved cysteines. Its members are recognised by the sequence pattern C-X-K-C-x-C-x(2)-C-K-C. The taxonomic range of the members extends to ascomycotina. The protein contains a number of unusual histidine and phenylalanine residues conserved in the N-terminal part of the sequence. This fragment does not contain any Cys. The protein binds to copper ions.
Pfam PF05534: HicB family (domain)
This family consists of several bacterial HicB related proteins. The function of HicB is unknown although it is thought to be involved in pilus formation. It has been speculated that HicB performs a function antagonistic to that of pili and yet is necessary for invasion of certain niches.
Pfam PF08951: Enterocin A Immunity (family)
Gram-positive lactobacilli produce bacteriocins to kill closely-related competitor species. To protect themselves from the bacteriocidal activity of this molecule they co-express an immunity protein (for discussion of this operon see Bacteriocin_IIc [pfam:PF10439]). The immunity protein structure is a soluble, cytoplasmic, antiparallel four alpha-helical globular bundle with a fifth, more flexible and more divergent C-terminal helical hair-pin. The C-terminal hair-pin recognises the C-terminus of the producer bacteriocin and this interaction is sufficient to dis-orient the bacteriocin within the membrane and close up the permeabilising pore that on its own the bacteriocin creates. These immunity proteins interact in the same way with other bacteriocins, family Bacteriocin_II, [pfam:PF01721]. Since many enterococci can produce more than one bacteriocin it seems likely that the whole operon can be carried on transferable plasmids.
Pfam PF05995: Cysteine dioxygenase type I (domain)
Cysteine dioxygenase type I ([ec:1.13.11.20]) converts cysteine to cysteinesulphinic acid and is the rate-limiting step in sulphate production.
Pfam PF24960: Domain of unknown function (DUF7766) (domain)
This domain is found in uncharacterised proteins mainly from Spirochaetales. It is predicted to fold into a double beta-barrel structure.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF00771: FHIPEP family (family)
The Flagellar/Hr/Invasion Proteins Export Pore (FHIPEP) family  consists of a number of proteins that constitute the type III secretion (or signal peptide-independent) pathway apparatus . This mechanism translocates proteins lacking an N-terminal signal peptide across the cell membrane in one step, as it does not require an intermediate periplasmic process to cleave the signal peptide. It is a common pathway amongst Gram-negative bacteria for secreting toxic and flagellar proteins.

The pathway apparatus comprises three components: two within the inner membrane and one within the outer . An FHIPEP protein is located within the inner membrane, although it is unknown which component it constitutes. FHIPEP proteins have all about 700 amino-acid residues. Within the sequence, the N terminus is highly conserved and hydrophobic, suggesting that this terminus is embedded within the membrane, with 6-8 transmembrane (TM) domains, while the C terminus is less conserved and appears to be devoid of TM regions. It is possible that members of the FHIPEP family serve as pores for the export of specific proteins.

Characterized proteins from the FHIPEP family include: the flagellar biosynthesis protein FlhA which is required for formation of the rod structure of the flagellar apparatus ; and the secretion system apparatus protein SsaV fromSalmonella typhimuriumwhich is required for the secretion of the SpvB toxin .
Wikipedia: In molecular biology, the FHIPEP protein family consists of a number of proteins that constitute the type III secretion pathway apparatus. This mechanism translocates proteins lacking an N-terminal signal peptide across the cell membrane in one step, as it does not require an intermediate periplasmic process to cleave the signal peptide. It is a common pathway amongst Gram-negative bacteria for secreting toxic and flagellar proteins.
Pfam PF15066: Cancer-associated gene protein 1 family (coiled_coil)
CAGE-1 is a family of proteins overexpressed in tumour tissues compared with surrounding tissues. CAGE-1 gene showed testis-specific expression among normal tissues and displayed wide expression in a variety of cancer cell lines and cancer tissues.  CAGE-1 is predominantly expressed during post-meiotic stages. It localises to the acrosomal matrix and acrosomal granule showing it to be a component of the acrosome of mammalian spermatids and spermatozoa.
Pfam PF10437: Bacterial lipoate protein ligase C-terminus (domain)
This is the C-terminal domain of a bacterial lipoate protein ligase.  There is no conservation between this C-terminus and that of vertebrate lipoate protein ligase C-termini, but both are associated with the domain BPL_LipA_LipB [pfam:PF03099], further upstream.  This domain is required for adenylation of lipoic acid by lipoate protein ligases. The domain is not required for transfer of lipoic acid from the adenylate to the lipoyl domain. Upon adenylation, this domain rotates 180 degrees away from the active site cleft. Therefore, the domain does not interact with the lipoyl domain during transfer.
Wikipedia: In molecular biology, the Cofactor transferase family is a family of protein domains that includes biotin protein ligases, lipoate-protein ligases A, octanoyl-(acyl carrier protein):protein N-octanoyltransferases, and lipoyl-protein:protein N-lipoyltransferases. The metabolism of the cofactors Biotin and lipoic acid share this family. They also share the target modification domain, and the sulfur insertion enzyme.
Pfam PF21124: VinK acyltransferase small domain (domain)
This family includes the VinK acyltransferase. VinK transfers a dipeptide group between two ACPs, VinL and VinP1LdACP, in vicenistatin biosynthesis. This entry represents the small C-terminal domain. VinK has two conserved catalytic residues, Ser-106 and His-216, at the interface between the large domain and small domain.
Pfam PF22130: Lactococcus phage gp38-like protein (family)
The gene product 38 (gp38) from Lactococcus phage P008 is a short protein consisting of 71 amino acids. It is also known as the AbiQ resistance protein due to its involvement in escaping bacterial killing mediated by the AbiQ protein. Gp38 is expressed early in the viral replication cycle and is essential for virus function.
Pfam PF07384: Protein of unknown function (DUF1497) (family)
This family consists of several phage and bacterial proteins of around 59 residues in length. Members of this family seem to be found exclusively in Lactococcus lactis and the bacteriophages that infect this organism. The function of this family is unknown.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF15407: Sporulation protein family 7 (domain)
Spo7_2 constitutes a different set of fungal and related species from those found in Spo7.  This domain is found in general at the N-terminus. In many members the domain is associated with a Pleckstrin-homology - PH - domain.
Pfam PF24994: GIL1/IRKI C-terminal domain (domain)
This domain is found in the Protein GRAVITROPIC IN THE LIGHT 1 (GIL1) and its paralogue IRK-interacting protein (IRKI) from Arabidopsis thaliana. This domain is predicted to fold into a structure similar to head domain of nucleotide exchange factor GrpE ([pfam:PF01025]). GIL1 is essential for light-dependent randomisation of hypocotyl growth orientation.
Pfam PF16615: Unstructured region one on RhoGEF 6 and 7 (disordered)
RhoGEF67_u1 is a region of natively unstructured residues on Rho guanine nucleotide exchange factor 6 and 7 proteins. The function is not known. It lies between the CH and the SH3 domains.
Pfam PF07191: Double zinc ribbon (family)
This family consists of several short, hypothetical bacterial proteins of around 70 residues in length. Members of this family have 8 highly conserved cysteine residues, which form two zinc beta-ribbon domains.
Pfam PF15322: Protein missing in infertile sperm 1, putative (family)
This family of proteins is found in eukaryotes. Proteins in this family are typically between 249 and 341 amino acids in length.
Pfam PF23964: Family of unknown function (DUF7292) (family)
This entry represents a family of uncharacterised phage proteins. These possibly have an N-terminal signal peptide followed by a small compact domain composed of a single alpha helix packed against a four stranded beta sheet.
Wikipedia: A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
Pfam PF17760: UvrA interaction domain (domain)
This domain found in UvrA proteins interacts with the UvrB protein.
Pfam PF12550: Transcriptional activator of glycolytic enzymes (family)
This domain family is found in eukaryotes, and is approximately 80 amino acids in length. This family is activates the transcription of glycolytic enzymes.
Pfam PF22878: SPT2 N-terminal domain (domain)
This entry represents a N-terminal conserved region found in the SPT2 family. SPT2 is a histone chaperone that stabilizes pre-existing histone tetramers and regulates replication-independent histone exchange on chromatin.
Pfam PF00536: SAM domain (Sterile alpha motif) (domain)
It has been suggested that SAM is an evolutionarily conserved protein binding domain that is involved in the regulation of numerous developmental processes in diverse eukaryotes. The SAM domain can potentially function as a protein interaction module through its ability to homo- and heterooligomerise with other SAM domains.
Wikipedia: In molecular biology, the protein domain Sterile alpha motif is a putative protein interaction module present in a wide variety of proteins involved in many biological processes. The SAM domain that spreads over around 70 residues is found in diverse eukaryotic organisms. SAM domains have been shown to homo- and hetero-oligomerise, forming multiple self-association architectures and also binding to various non-SAM domain-containing proteins, nevertheless with a low affinity constant.
Pfam PF18915: Domain of unknown function (DUF5667) (domain)
This presumed domain is functionally uncharacterised. This domain family is found in bacteria and archaea, and is typically between 95 and 113 amino acids in length.
Pfam PF18309: Argonaute PAZ domain (domain)
This is a PAZ domain is found in argonaute present in Thermus thermophiles.  Argonaute has a central role in the RNA interference pathway by mediating the maturation of small interfering RNA (siRNA) through initial degradation of the passenger strand, followed by guide-strand-mediated sequence-specific cleavage of target mRNA. The nucleic-acid-binding channel is thought to be positioned between the PAZ and PIWI domain.