Title: Penicillin
Content:  to be suitable. When probenecid and penicillin are administered together, probenecid competitively inhibits the excretion of penicillin, increasing penicillin's concentration and prolonging its activity. Eventually, the advent of mass-production techniques and semi-synthetic penicillins resolved the supply issues, so this use of probenecid declined. Probenecid is still useful, however, for certain infections requiring particularly high concentrations of penicillins. After World War II, Australia was the first country to make the drug available for civilian use. In the U.S., penicillin was made available to the general public on March 15, 1945. Fleming, Florey, and Chain shared the 1945 Nobel Prize in Physiology or Medicine for the development of penicillin.
Title: May 1943
Content: Following years of experimentation to test the safety of the first antibiotic drug, the United States Army Medical Corps cleared the release of penicillin for use in all military hospitals. Two days later, the first patient to receive the drug would be an unidentified U.S. Army soldier. Although the bacteria-killing properties of the mold Penicillium chrysogenum had been discovered by Alexander Fleming 15 years earlier, production was limited until 1942, when a potent strain of the mold was discovered on a cantaloupe that had been discarded from a market in Peoria, Illinois, where research was being performed on synthesizing the drug. The "Peoria strain" was found by microbiologist Dorothy I. Fennell to yield 50 times 
Title: History of penicillin
Content:  Fleming performed the first clinical trial with penicillin on Craddock. Craddock had developed severe infection of the nasal antrum (sinusitis) and had undergone surgery. Fleming made use of the surgical opening of the nasal passage and started injecting penicillin on 9 January 1929 but without any effect. It probably was due to the fact that the infection was with influenza bacillus (Haemophilus influenzae), the bacterium which he had found unsusceptible to penicillin. Fleming gave some of his original penicillin samples to his colleague-surgeon Arthur Dickson Wright for clinical test in 1928. Although Wright reportedly said that it "seemed to work satisfactorily," there are no 
Title: Penicillin
Content:  to penicillin are most often given cephalosporin C (another β-lactam antibiotic) because there is only 10% crossover in allergy between the penicillins and cephalosporins. Penicillin was discovered in 1928 by Scottish scientist Alexander Fleming as a crude extract of P. rubens. Fleming's student Cecil George Paine was the first to successfully use penicillin to treat eye infection (ophthalmia neonatorum) in 1930. The purified compound (penicillin F) was isolated in 1940 by a research team led by Howard Florey and Ernst Boris Chain at the University of Oxford. Fleming first used the purified penicillin to treat streptococcal meningitis in 1942. For the discovery, Fleming shared the 1945 Nobel Prize in Physiology or Medicine with Florey and Chain. Several semisynthetic penicillins are effective against a broader spectrum of bacteria: these include the antistaphylococcal penicillins, aminopenicillins and the antipseudomonal penicillins.
Title: Roaring Twenties
Content:  For decades biologists had been at work on the medicine that became penicillin. In 1928, Scottish biologist Alexander Fleming discovered a substance that killed a number of disease-causing bacteria. In 1929, he named the new substance penicillin. His publications were largely ignored at first, but it became a significant antibiotic in the 1930s. In 1930, Cecil George Paine, a pathologist at Sheffield Royal Infirmary, used penicillin to treat sycosis barbae, eruptions in beard follicles, but was unsuccessful. Moving to ophthalmia neonatorum, a gonococcal infection in infants, he achieved the first recorded cure with penicillin, on November 25, 1930. He then cured four additional patients (one adult and three infants) of eye infections, but failed to cure a fifth.
Title: Penicillin
Content:   Starting in the late 19th century there had been reports of the antibacterial properties of Penicillium mould, but scientists were unable to discern what process was causing the effect. Scottish physician Alexander Fleming at St Mary's Hospital in London (now part of Imperial College) was the first to show that Penicillium rubens had antibacterial properties. On 3 September 1928 he observed that fungal contamination of a bacterial culture (Staphylococcus aureus) appeared to kill the bacteria. He confirmed this observation with a new experiment on 28 September 1928. He published his experiment in 1929, and called the antibacterial substance (the fungal extract) penicillin. C. J. La Touche identified the fungus as Penicillium rubrum (later reclassified by Charles Thom as P. notatum and P. chrysogenum, but later corrected 
Title: Penicillin
Content:  By 1943, Rettew's lab was producing most of the world's penicillin. During World War II, penicillin made a major difference in the number of deaths and amputations caused by infected wounds among Allied forces, saving an estimated 12%–15% of lives. Availability was severely limited, however, by the difficulty of manufacturing large quantities of penicillin and by the rapid renal clearance of the drug, necessitating frequent dosing. Methods for mass production of penicillin were patented by Andrew Jackson Moyer in 1945. Florey had not patented penicillin, having been advised by Sir Henry Dale that doing so would be unethical. Penicillin is actively excreted, and about 80% of a 
Title: State microbe
Content:  The world's first antibiotic, penicillin, is produced by a strain of the mold Penicillium rubens (formerly Penicillium chrysogenum). Though the history of penicillin is centuries long, Scottish physician Alexander Fleming is usually credited with initiating the modern era of penicillin discovery, research, and development when he found the mold (Penicillium notatum, now also P. rubens) growing on a culture plate in his laboratory in 1928. Penicillin is effective on gram-positive bacteria. The antibiotic-producing strains of Penicillium in the early years produced relatively low yields of unstable penicillin. The yields were so low that urine from treated patients was collected and the penicillin remaining extracted and reused. 
Title: Penicillin
Content:  treated successfully. In December 1942, survivors of the Cocoanut Grove fire in Boston were the first burn patients to be successfully treated with penicillin. The first successful use of pure penicillin was when Fleming treated Harry Lambert of fatal infection of the nervous system (streptococcal meningitis) in 1942. By that time the Oxford team could produce only a small amount. Florey willingly gave the only available sample to Fleming. Lambert showed improvement from the very next day of the treatment, and was completely cured within a week. Fleming published his clinical trial in The Lancet in 1943. Following the medical breakthrough the British War Cabinet set up the Penicillin Committee on 5 April 1943 that led to projects for mass production.
Title: Alvin Ingram
Content:  the United States. In addition to administering some of the first doses of penicillin, Ingram promoted its use to the surrounding Brigham community. In speech by then-Captain Alvin Ingram to the Rotary Club of Brigham City, he explained how penicillin was discovered in 1928 by Alexander Fleming, and extolled recent successes of administering the drug at nearby Bushnell Hospital. According to historian Richard Polenberg, “[w]artime advances in medicine, particularly in the production of penicillin (which first became generally available for civilian use in the spring of 1944) saved countless [military and civilian] lives. Colonel Robert M. Hardaway MD, commanding officer of Bushnell, participated in Ingram's wedding to Catherine Davis as her "father by proxy" since her father was unable to attend.

Question: when was penicillin first introduced to the public?
Answer: After World War II.
1942.