Title: Paul di Sant'Agnese
Content:  Paul di Sant'Agnese (1914–2005 ) was the founder of the Cystic Fibrosis Foundation and of Cystic Fibrosis Care in the United States. He was a physician, researcher and one of the first clinicians who devoted his life to understanding and conquering cystic fibrosis through his work at the Columbia University Medical Center, New York City. Undoubtedly the major advance during the Fifties was the recognition of the increased salt content of the sweat in people with CF by Paul di Sant’Agnese in 1953. During the heat wave of 1949, he was the first to recognize that infants suffering from cystic fibrosis were at special risk for heat prostration. He thus discovered that sweat was abnormal in CF. His discovery of abnormalities in sweat electrolytes lead to the sweat test, which is a primary method for diagnosing cystic fibrosis and was developed and improved over the next decade. This remains the cornerstone of the diagnosis of the disease— but also opened up areas of research that ultimately helped to identify the basic defect in cystic fibrosis.
Title: Cystic Fibrosis Foundation
Content:  The Foundation was established in 1955 by a group of volunteers in Philadelphia, Pennsylvania. In addition to providing grants for research into cystic fibrosis and supporting clinical trials, the foundation promotes and accredits 115 specialized centers for treatment of individuals with cystic fibrosis. The Foundation has over 80 chapters and offices across the United States. Before it began using the current name, the organization was known as the "National Cystic Fibrosis Research Foundation". In 1989, scientists working for the Cystic Fibrosis Foundation discovered the gene that causes cystic fibrosis, considered the key to developing a cure for cystic fibrosis. From 1982 until 1999, sports journalist Frank Deford served as chairman of the Foundation. The Cystic Fibrosis Foundation has been a pioneer of cystic fibrosis treatment, having played a major role in the development and use of five FDA-approved therapies, including ivacaftor (Kalydeco). The latest FDA approved drug is Trikafta, which was passed by the FDA in 54 days and is able to help up to 90% of CF patients. In 2014, the Cystic Fibrosis Foundation sold the rights to the royalties of the drugs for $3.3 billion, twenty times the Foundation's 2013 budget.
Title: Cystic fibrosis
Content:  the lung and intestinal disease prominent in CF. She also first hypothesized that CF was a recessive disease and first used pancreatic enzyme replacement to treat affected children. In 1952, Paul di Sant'Agnese discovered abnormalities in sweat electrolytes; a sweat test was developed and improved over the next decade. The first linkage between CF and another marker (Paroxonase) was found in 1985 by Hans Eiberg, indicating that only one locus exists for CF. In 1988, the first mutation for CF, ΔF508 was discovered by Francis Collins, Lap-Chee Tsui, and John R. Riordan on the seventh chromosome. Subsequent research has found 
Title: History of chronic fatigue syndrome
Content:  and more so after the criteria were relaxed in 1994. In 1990, researchers presented evidence they found DNA sequences very similar to the human HTLV-II retrovirus in some CFS patients, at a conference in Kyoto, Japan. Their study was later published in the Proceedings of the National Academy of Sciences. A reporter on Prime Time Live stated the announcement made headlines all over the world. The CDC first ignored their findings, then later conducted a study and published a paper that refuted the hypothesis. In the United Kingdom, the Chief Medical Officer Kenneth Calman requested a report from the medical Royal 
Title: Cystic fibrosis
Content:   CF is supposed to have appeared about 3,000 BC because of migration of peoples, gene mutations, and new conditions in nourishment. Although the entire clinical spectrum of CF was not recognized until the 1930s, certain aspects of CF were identified much earlier. Indeed, literature from Germany and Switzerland in the 18th century warned "Wehe dem Kind, das beim Kuß auf die Stirn salzig schmeckt, es ist verhext und muss bald sterben" ("Woe to the child who tastes salty from a kiss on the brow, for he is cursed and soon must die"), recognizing the association between the salt loss in CF 
Title: Cystic fibrosis
Content:  illness. In the 19th century, Carl von Rokitansky described a case of fetal death with meconium peritonitis, a complication of meconium ileus associated with CF. Meconium ileus was first described in 1905 by Karl Landsteiner. In 1936, Guido Fanconi described a connection between celiac disease, cystic fibrosis of the pancreas, and bronchiectasis. In 1938, Dorothy Hansine Andersen published an article, "Cystic Fibrosis of the Pancreas and Its Relation to Celiac Disease: a Clinical and Pathological Study", in the American Journal of Diseases of Children. She was the first to describe the characteristic cystic fibrosis of the pancreas and to correlate it 
Title: Guido Fanconi
Content:  known as Fanconi anemia. In 1934 the first cases of cystic fibrosis of the pancreas were described in a thesis written under his direction. In 1941 a large epidemic of poliomyelitis occurred in Switzerland. Fanconi analyzed its epidemiology and found that the virus was not transmitted by droplet infection, as previously assumed, but rather follows a gastrointestinal pathway like typhoid fever. His understanding of pathophysiologic connections culminated in his prediction that Down syndrome was due to a chromosomal abnormality, 20 years before trisomy 21 was discovered. His contributions to renal physiology led to renal Fanconi syndrome being named for him. In 1945 he founded a new pediatric journal, Helvetica Paediatrica Acta, which has become an internationally renowned periodical. Dr. Fanconi retired in 1965 from his chairmanship in pediatrics, but continued to practice and lecture until his death.
Title: Canadian Friends Service Committee
Content:  Canadian Friends Service Committee (CFSC) was founded in 1931 when members of the Religious Society of Friends or "Quakers" wanted a vehicle to act upon their peace and social justice concerns. That year, Fred Haslam "was instrumental in the organization of the CFSC, and, as its executive secretary for the next twenty-five years, he was personally responsible for the day-to-day direction of its activities, especially those concerning world peace and the abolition of capital punishment". Since its founding, CFSC has worked on many projects related to peace and justice. In 1947, the Religious Society of Friends (Quakers) received the Nobel 
Title: Congress for Cultural Freedom
Content:  The Congress for Cultural Freedom (CCF) was an anti-communist advocacy group founded in 1950. At its height, the CCF was active in thirty-five countries. In 1966 it was revealed that the CIA was instrumental in the establishment and funding of the group. Historian Frances Stonor Saunders writes (1999): "Whether they liked it or not, whether they knew it or not, there were few writers, poets, artists, historians, scientists, or critics in postwar Europe whose names were not in some way linked to this covert enterprise." A different slant on the origins and work of the Congress is offered by Peter Coleman in his Liberal Conspiracy (1989), where he talks about a struggle for the mind "of Postwar Europe" and the world at large.
Title: David Sheffield Bell
Content:  CDC didn't mention a similar outbreak in Lake Tahoe, which he learned about later. He met with other CFS researchers at a 1987 conference, and joined an investigation with researchers Paul Cheney and Elaine DeFreitas involving a possible retrovirus association with chronic fatigue syndrome. In 1990, the researchers presented evidence they found DNA sequences very similar to a known human retrovirus in some CFS patients, at a conference in Kyoto, Japan. Their study was later published in the Proceedings of the National Academy of Sciences. A reporter on Prime Time Live stated the announcement made headlines all over the world. The CDC first ignored their findings, then later conducted a study and published a 

Question: when was the problem of cfc's discovered?
Answer: late 1970s.
1974.
1973.
1970s.