Title: Issus (Cilicia)
Content:  Persian Empire.  Issus or Issos (Phoenician: Sissu, or Ἱσσοί) is an ancient settlement on the strategic coastal plain straddling the small Pinarus river (a fast melt-water stream several metres wide) below the navigationally difficult inland mountains towering above to the east in the Turkish Province of Hatay, near the border with Syria. It can be identified with Kinet Höyük in the village of Yeṣilköy near Dörtyol in the Hatay province of Turkey. Excavations on the mound occurred between 1992 and 2012 by Bilkent University. It is most notable for being the place of no fewer than three decisive ancient or medieval battles each called in their 
Title: Issus (Cilicia)
Content:  era the Battle of Issus:  Whether Issus is still present within a modern settlement is hotly debated among researchers. Regardless of which mountain brook was the locus of the battles, the old town was situated close to present-day İskenderun, Turkey, in the Gulf of İskenderun. Today, no town exists on both sides of the Pinarus river, which may or may not have been called Issus. Although Issus was once considered to have been an episcopal see, there is no evidence to support that idea: Issus is not mentioned in the "Notitiae Episcopatuum" of the Patriarchate of Antioch, to which the Roman province of Cilicia belonged.
Title: Issus (Cilicia)
Content: 1) The Battle of Issus (333 BC); Alexander the Great of Macedonia defeated Darius III of Persia. This battle is occasionally called the First Battle of Issus, but is more generally known simply as the Battle of Issus, owing to the importance of Alexander's victory over the First Persian Empire and its impact on subsequent history of the region, including all the successor polities. ; 2) Battle of Issus (194), or Second Battle of Issus &mdash; between the forces of Emperor Septimius Severus and his rival, Pescennius Niger. ; 3) Battle of Issus (622), or Third Battle of Issus &mdash; between the Byzantine Empire and the 
Title: Issus (river)
Content:  Issus, a river in Cilicia, Asia Minor, where Alexander the Great defeated Darius in 333 BC.
Title: Battle of Issus (194)
Content:  The Battle of Issus was the third major battle in AD 194 between the forces of Emperor Septimius Severus and his rival, Pescennius Niger, part of the Year of the Five Emperors. Severus won the battle, and Niger was captured and killed shortly afterwards.
Title: Battle of Issus
Content:  The Battle of Issus (also Issos) occurred in southern Anatolia, on November 5, 333 BC between the Hellenic League led by Alexander the Great and the Achaemenid Empire, led by Darius III. It was the second great battle of Alexander's conquest of Asia, and the first encounter between Darius III and Alexander the Great. The battle resulted in the Macedonian troops defeating the Persian forces. After the Hellenic League soundly defeated the Persian satraps of Asia Minor (led by Greek mercenary Memnon of Rhodes) at the Battle of the Granicus, Darius took personal command of his army. He gathered reinforcements and proceeded to lead his men in a surprise march behind the Hellenic advance, in order to cut off their line of supply. Alexander was forced to countermarch, and the stage was set for the battle near the mouth of the Pinarus River and the town of Issus.
Title: Battle of Issus (194)
Content:  Eventually, Anullinus entered Syria, and the final battle took place in May 194, near Issus, the place where Alexander the Great had defeated the Persian King Darius III in 332 BC. Severus took advantage of the control he had on the lives of the children of the provincial governors, who were left at Rome, and of the rivalries of the cities in the region, thus encouraging governors to change sides, one legion to desert to him, and some cities to revolt. Severan troops attacked first, while Niger's forces were hurling missiles onto them. According to Dio, Severan legionaries applied testudo, using their shields for protecting either themselves or their own missile shooters (however, it seems that it was not the real testudo that was used in sieges or against highly mobile attackers ). At the same time, the Severan cavalry attacked from the rear. The fight was hard, but in the end, Severus won decisively and Niger fled back to Antioch. A sudden thunderstorm played some role in lowering the morale of Niger's troops, who were directly facing it, because they had attributed it to divine intervention. A triumphal arch was set on site, commemorating the victory of Severus.
Title: Wars of Alexander the Great
Content:  instead jumped off. He threw his royal diadem away, mounted a horse, and fled the scene. The Persian troops, realizing they had lost, either surrendered or fled with their hapless king. The Macedonian cavalry pursued the fleeing Persians for as long as there was light. As with most ancient battles, significant carnage occurred after the battle as pursuing Macedonians slaughtered their crowded, disorganized foe. The Battle of Issus occurred in southern Anatolia, in November 333 BC. The invading troops led by Alexander were outnumbered more than 2:1, yet they defeated the army personally led by Darius III of Achaemenid Persia. The battle was a decisive Macedonian victory and it marked the beginning of the end 
Title: Battle of Issus
Content:   The battle took place south of the ancient town Issus, which is close to the present-day Turkish town of Iskenderun (the Turkish equivalent of "Alexandria", founded by Alexander to commemorate his victory), on either side of a small river called Pinarus. At that location, the distance from the Gulf of Issus to the surrounding mountains is only 2.6 km, a place where Darius could not take advantage of his superiority in numbers. Speculation on the location of the Pinarus has taken place for over 80 years. Older historians believed it to be the Deli Tchai river, but historians N.G.L. Hammond and A. M. Devine claim that the Pinarus is actually the Payas River, the latter using his own examination of the course of the river, which he considered would not have drastically changed since antiquity. Their evidence is based on Callisthenes' accounts of the measurements of the battlefield and distances marched by both sides' armies in the prelude to the battle and distance given by Diodorus after the battle.
Title: Battle of Issy
Content:  The Battle of Issy was fought on the 2 and 3 July 1815 in and around the village of Issy, a short distance south west of Paris. The result was a victory for Prussian General von Zieten over a French army commanded by General Dominique Vandamme.

Question: where did the battle of issus take place?
Answer: southern Anatolia.
in southern Anatolia.