Question: How to diagnose Primary gastrointestinal melanoma ?
Answer: How might primary melanoma of the small intestine be diagnosed? A variety of tests may be involved in the initial diagnosis of the tumor, including contrast radiography, endoscopy, and CT scan. The tumor is confirmed by surgical resection. Careful study of tissue samples from the tumor under a microscope will show the same immunohistochemical characteristics of skin melanomas. Once this has been established, the following are proposed diagnostic criteria for primary melanoma of the small intestine: 1. The absence of a previous or synchronously resected melanoma or atypical melanocytic lesion of the skin. 2. The absence of metastatic spread to other organs. 3. The presence of intramucosal lesions of the overlying or adjacent intestinal mucosa.
Source: GARD