Question: What causes Zollinger-Ellison Syndrome ?
Answer: Experts do not know the exact cause of Zollinger-Ellison syndrome. About 25 to 30 percent of gastrinomas are caused by an inherited genetic disorder called multiple endocrine neoplasia type 1 (MEN1).1 MEN1 causes hormone-releasing tumors in the endocrine glands and the duodenum. Symptoms of MEN1 include increased hormone levels in the blood, kidney stones, diabetes, muscle weakness, weakened bones, and fractures. More information about MEN1 is provided in the NIDDK health topic, Multiple Endocrine Neoplasia Type 1.
Source: NIDDK

Question: What are the symptoms of Zollinger-Ellison Syndrome ?
Answer: Zollinger-Ellison syndrome signs and symptoms are similar to those of peptic ulcers. A dull or burning pain felt anywhere between the navel and midchest is the most common symptom of a peptic ulcer. This discomfort usually - occurs when the stomach is emptybetween meals or during the nightand may be briefly relieved by eating food - lasts for minutes to hours - comes and goes for several days, weeks, or months Other symptoms include - diarrhea - bloating - burping - nausea - vomiting - weight loss - poor appetite Some people with Zollinger-Ellison syndrome have only diarrhea, with no other symptoms. Others develop gastroesophageal reflux (GER), which occurs when stomach contents flow back up into the esophagusa muscular tube that carries food and liquids to the stomach. In addition to nausea and vomiting, reflux symptoms include a painful, burning feeling in the midchest. More information about GER is provided in the NIDDK health topic, Gastroesophageal Reflux (GER) and Gastroesophageal Reflux Disease (GERD) in Adults.
Source: NIDDK

Question: What to do for Zollinger-Ellison Syndrome ?
Answer: Researchers have not found that eating, diet, and nutrition play a role in causing or preventing Zollinger-Ellison syndrome.
Source: NIDDK