Question: What are the treatments for Kleine-Levin Syndrome ?
Answer: There is no definitive treatment for Kleine-Levin syndrome and watchful waiting at home, rather than pharmacotherapy, is most often advised. Stimulant pills, including amphetamines, methylphenidate, and modafinil, are used to treat sleepiness but may increase irritability and will not improve cognitive abnormalities. Because of similarities between Kleine-Levin syndrome and certain mood disorders, lithium and carbamazepine may be prescribed and, in some cases, have been shown to prevent further episodes. This disorder should be differentiated from cyclic re-occurrence of sleepiness during the premenstrual period in teen-aged girls, which may be controlled with birth control pills. It also should be differentiated from encephalopathy, recurrent depression, or psychosis.
Source: NINDS

Question: What is the outlook for Kleine-Levin Syndrome ?
Answer: Episodes eventually decrease in frequency and intensity over the course of eight to 12 years.
Source: NINDS

Question: what research (or clinical trials) is being done for Kleine-Levin Syndrome ?
Answer: NINDS supports a broad range of clinical and basic research on diseases causing sleep disorders in an effort to clarify the mechanisms of these conditions and to develop better treatments for them.
Source: NINDS