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    <div class="table-caption">
        <span class="label">Table 6</span>
        <span class="caption">Biomarker assessment.</span>
    </div>
    <table class="table table-bordered table-condensed table-hover table-text" data-jats-content-type="text">
<colgroup>
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<thead>
<tr>
<th>Study</th>
<th>Process-specific classification</th>
<th>Methodologic quality</th>
<th>Clinical utility</th>
<th>Clinical usefulness</th>
<th>Biomarker validity</th>
</tr>
</thead>
<tbody>
<tr>
<td><a class="xref xref-bibr" data-jats-ref-type="bibr" data-jats-rid="ref-7" href="https://doi.org/10.1136%2Fjnnp.59.2.152" title="Diagnostic value of paraclinical tests in multiple sclerosis: relative sensitivities and specificities for reclassification according to the Poser committee criteria">Beer, Rösler &amp; Hess (1995)</a></td>
<td>Axonal damage</td>
<td>N</td>
<td>U</td>
<td>N</td>
<td>N</td>
</tr>
<tr>
<td><a class="xref xref-bibr" data-jats-ref-type="bibr" data-jats-rid="ref-11" href="https://doi.org/10.1016%2Fj.clinph.2003.11.024" title="Brain excitability changes in the relapsing and remitting phases of multiple sclerosis: a study with transcranial magnetic stimulation">Caramia et al. (2004)</a></td>
<td>Demyelination,<br/>axonal damage</td>
<td>N</td>
<td>N</td>
<td>N</td>
<td>N</td>
</tr>
<tr>
<td><a class="xref xref-bibr" data-jats-ref-type="bibr" data-jats-rid="ref-17" href="https://scholar.google.com/scholar_lookup?title=Disability%20in%20multiple%20sclerosis.%20the%20role%20of%20transcranial%20magnetic%20stimulation&amp;author=Cruz-Mart%C3%ADnez&amp;publication_year=2000" title="Disability in multiple sclerosis. the role of transcranial magnetic stimulation">Cruz-Martínez et al. (2000)</a></td>
<td>Demyelination,<br/>axonal damage</td>
<td>N</td>
<td>Y</td>
<td>N</td>
<td>N</td>
</tr>
<tr>
<td><a class="xref xref-bibr" data-jats-ref-type="bibr" data-jats-rid="ref-21" href="https://doi.org/10.1017%2FS0317167100033011" title="Motor evoked potentials and disability in secondary progressive multiple sclerosis">Facchetti et al. (1997)</a></td>
<td>Demyelination,<br/>axonal damage</td>
<td>N</td>
<td>U</td>
<td>U</td>
<td>N</td>
</tr>
<tr>
<td><a class="xref xref-bibr" data-jats-ref-type="bibr" data-jats-rid="ref-31" href="https://doi.org/10.1002%2Fana.410220611" title="Magnetic brain stimulation: central motor conduction studies in multiple sclerosis">Hess et al. (1987)</a></td>
<td>Demyelination,<br/>axonal damage</td>
<td>N</td>
<td>U</td>
<td>N</td>
<td>N</td>
</tr>
<tr>
<td><a class="xref xref-bibr" data-jats-ref-type="bibr" data-jats-rid="ref-34" href="https://doi.org/10.1016%2Fj.jns.2006.08.008" title="Ipsilateral silent period: a marker of callosal conduction abnormality in early relapsing-remitting multiple sclerosis?">Jung et al. (2006)</a></td>
<td>Demyelination,<br/>axonal damage</td>
<td>N</td>
<td>N</td>
<td>N</td>
<td>N</td>
</tr>
<tr>
<td><a class="xref xref-bibr" data-jats-ref-type="bibr" data-jats-rid="ref-35" href="https://doi.org/10.1016%2Fj.jocn.2009.03.009" title="Correlation between disability and transcranial magnetic stimulation abnormalities in patients with multiple sclerosis">Kale et al. (2009)</a></td>
<td>Demyelination,<br/>axonal damage</td>
<td>N</td>
<td>U</td>
<td>N</td>
<td>N</td>
</tr>
<tr>
<td><a class="xref xref-bibr" data-jats-ref-type="bibr" data-jats-rid="ref-36" href="https://doi.org/10.1179%2F016164109X12445616596526" title="Electrophysiological and clinical correlates of corpus callosum atrophy in patients with multiple sclerosis">Kale, Agaoglu &amp; Tanik (2010)</a></td>
<td>Demyelination,<br/>axonal damage</td>
<td>N</td>
<td>U</td>
<td>U</td>
<td>N</td>
</tr>
<tr>
<td><a class="xref xref-bibr" data-jats-ref-type="bibr" data-jats-rid="ref-37" href="https://doi.org/10.1016%2F0022-510X%2891%2990189-E" title="The role of magnetic stimulation in the diagnosis of multiple sclerosis">Kandler et al. (1991)</a></td>
<td>Demyelination</td>
<td>N</td>
<td>U</td>
<td>N</td>
<td>N</td>
</tr>
<tr>
<td><a class="xref xref-bibr" data-jats-ref-type="bibr" data-jats-rid="ref-41" href="https://doi.org/10.1136%2Fjnnp.2005.086280" title="Multimodal evoked potentials to assess the evolution of multiple sclerosis: a longitudinal study">Leocani et al. (2006)</a></td>
<td>Demyelination,<br/>axonal damage, remyelination</td>
<td>N</td>
<td>U</td>
<td>U</td>
<td>N</td>
</tr>
<tr>
<td><a class="xref xref-bibr" data-jats-ref-type="bibr" data-jats-rid="ref-43" href="https://doi.org/10.1093%2Fbrain%2F122.2.265" title="A clinical study of motor evoked potentials using a triple stimulation technique">Magistris et al. (1999)</a></td>
<td>Demyelination,<br/>axonal damage</td>
<td>N</td>
<td>U</td>
<td>N</td>
<td>N</td>
</tr>
<tr>
<td><a class="xref xref-bibr" data-jats-ref-type="bibr" data-jats-rid="ref-45" href="https://doi.org/10.1212%2Fwnl.41.4.566" title="The sensitivity of transcranial cortical magnetic stimulation in detecting pyramidal tract lesions in clinically definite multiple sclerosis">Mayr et al. (1991)</a></td>
<td>Demyelination</td>
<td>U</td>
<td>U</td>
<td>N</td>
<td>N</td>
</tr>
<tr>
<td><a class="xref xref-bibr" data-jats-ref-type="bibr" data-jats-rid="ref-52" href="https://doi.org/10.1016%2Fj.clinph.2019.11.024" title="Upper limb motor evoked potentials as outcome measure in progressive multiple sclerosis">Pisa et al. (2020)</a></td>
<td>Demyelination</td>
<td>N</td>
<td>U</td>
<td>U</td>
<td>N</td>
</tr>
<tr>
<td><a class="xref xref-bibr" data-jats-ref-type="bibr" data-jats-rid="ref-54" href="https://doi.org/10.1212%2FWNL.42.7.1296" title="The diagnostic reliability of magnetically evoked motor potentials in multiple sclerosis">Ravnborg et al. (1992)</a></td>
<td>Demyelination</td>
<td>N</td>
<td>U</td>
<td>N</td>
<td>N</td>
</tr>
<tr>
<td><a class="xref xref-bibr" data-jats-ref-type="bibr" data-jats-rid="ref-62" href="https://doi.org/10.1136%2Fjnnp.68.5.633" title="Conduction deficits of callosal fibres in early multiple sclerosis">Schmierer et al. (2000)</a></td>
<td>Demyelination,<br/>axonal damage</td>
<td>N</td>
<td>U</td>
<td>N</td>
<td>N</td>
</tr>
<tr>
<td><a class="xref xref-bibr" data-jats-ref-type="bibr" data-jats-rid="ref-61" href="https://doi.org/10.1212%2FWNL.59.8.1218" title="Correlates of disability in multiple sclerosis detected by transcranial magnetic stimulation">Schmierer et al. (2002)</a></td>
<td>Demyelination,<br/>axonal damage</td>
<td>N</td>
<td>U</td>
<td>N</td>
<td>N</td>
</tr>
<tr>
<td><a class="xref xref-bibr" data-jats-ref-type="bibr" data-jats-rid="ref-75" href="https://doi.org/10.1016%2FS0303-8467%2802%2900127-0" title="Cortical silent period and motor evoked potentials in patients with multiple sclerosis">Tataroglu et al. (2003)</a></td>
<td>Demyelination,<br/>excitotoxicity, axonal damage</td>
<td>N</td>
<td>U</td>
<td>N</td>
<td>N</td>
</tr>
</tbody>
</table>
    <div class="note">
        Note: H, high; L, low; N, no; U, uncertain. See ref: ( Bielekova & Martin, 2004 ).
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